gebhart/patrepeval huggingface dataset:
Municipal Solid Waste Composition Studies (1997)

This project develops a methodology for municipal solid waste (MSW) composition studies in the state of Florida. A technical advisory group (TAG) was formed and a public workshop organized to evaluate the suggestions and methodologies developed as a result of the project and to obtain relevant feedback. Thirty-six MSW studies previously conducted in Florida counties were evaluated and reviewed for compatibility with the national guidelines and consistency with other Florida counties. This information was utilized to produce statistics and a methodology specific to Florida. The methodology was then modeled into a knowledge-based system to guide future users and promote consistency in MSW composition studies in the state of Florida. A summary of the recommended methodology and results is provided.
Noncompaction of the ventricular myocardium and hydrops fetalis in cobalamin C disease (2013)

None.
319 PROTEIN GENE PRODUCT 9.5 REGULATES SPERM PENETRATION DURING PORCINE FERTILIZATION IN VITRO (2006)

The protein gene product 9.5 (PGP9.5) belongs to a family of ubiquitin C-terminal hydrolases (UCHs), which regenerate monoubiquitin from ubiquitin–protein complexes or polyubiquitin chains by cleaving the amide linkage next to the C-terminal glycine of ubiquitin. Identified in the acrosome of boar spermatozoa, we hypothesized that PGP9.5 might regulate sperm–zona pellucida interactions during porcine IVF. The cumulus–oocyte complexes isolated from slaughterhouse ovaries were cultured in TCM-199 media for 44 h at 38.5°C, 5% CO2 in air. After completion of in vitro maturation (IVM), cumulus cells were removed by 0.1% hyaluronidase, and metaphase II (MII) oocytes were used for IVF. In Experiment 1, oocytes were co-incubated with different sperm concentrations (1 × 106, 5 × 105, and 1 × 105 sperm mL-1) in TBM medium with or without anti-PGP9.5 antibody (1 : 50 dilution). In Experiment 2, oocytes were inseminated with 1 × 106 sperm mL-1 in TBM medium containing different concentrations of extracted oviductal fluids (0, 0.1, 0.5, 1, 2, and 3 µg mL-1) for 6 h. After IVF, oocytes were transferred into NCSU23 medium containing 0.4% BSA for further culture. The fertilization rates were evaluated by DAPI staining at 13 to 19 h. Data were analyzed by ANOVA and Duncan's multiple range test using the SAS program. Polyspermy was increased by the addition of anti-PGP9.5 antibody to the IVF medium (56.5–60.2% at polyspermy). This PGP9.5-antibody-induced polyspermy increase was sustained even with decreasing sperm concentrations. The polyspermy rates were reduced by the addition of isolated porcine oviductal fluid to IVF medium (50.4, 44.8, 28.0, 31.1, 1.6, and 0.0% at oviductal fluid concentrations of 0, 0.1, 0.5, 1, 2, and 3 µg mL-1, respectively). Biochemical analysis by Western blotting detected the appropriate 24-kDa PGP9.5 band in porcine oviductal fluid used for these experiments. Enzymatic UCH activity comparable to activity of recombinant UCH-L3 was detected in sperm extract, whole spermatozoa, and isolated oviductal fluid by fluorometric assay using fluorogenic UCH-substrate ubiquitin-AMC. This UCH activity was not reduced by the general protease inhibitor phenyl methyl sylfonyl fluoride, but it was reduced in a statistically significant manner ( P &amp;lt; 0.05) by the specific UCH-inhibitor ubiquitin aldehyde. In conclusion, the polyspermy increased with different concentrations of sperm in the anti-PGP9.5 antibody, and PGP9.5 was detected in oviductal fluids, suggesting that PGP9.5 is involved in the sperm–zona pellucida interaction during porcine fertilization. This work was supported by the US Department of Agriculture (USDA-NRI grant #2002-35203-12237 to P.S.), the F21C Program of The University of Missouri–Columbia (P.S.), and the ERC Program of the Korea Science and Engineering Foundation (KOSEF grant no. R11-2002-100-00000-0 to Y.J. Yi and C.S. Park) .
Human prostate cancer xenografts in lit/lit mice exhibit reduced growth and androgen‐independent progression (2010)

This study demonstrates that circulating GH and IGF-I can promote androgen-responsive growth, CR progression, and AI expansion of PTEN-deficient human PCa cell xenografts and indicates that IGF-I can promote PCa growth in a suppressed GH environment.
Distributed Querying of Internet Distance Information (2006)

Estimation of network proximity among nodes is an important building block in several applications like service selection and composition, multicast tree formation, and overlay construction. Recently, scalable techniques have been proposed to estimate inter-node latencies, including network coordinate systems like GNP and Vivaldi. However, existing mechanisms for querying such information do not scale well to a very large number of nodes, when one wants to accurately find a set of nodes globally closest to a given node. In this paper we are concerned with distributing the position data among a set of infrastructure nodes, and propose ways of partitioning and querying this data. The trade-offs between accuracy and overhead in this distributed infrastructure are explored. We evaluate our solution through simulations with real and synthetic network measurement data.
ChemInform Abstract: Cytotoxic Michael‐Type Amine Adducts of α‐Methylene Lactones Alantolactone and Isoalantolactone. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Identification of reversible and irreversible deactivation of MDA catalysts: A key to design a viable process (2023)

We report a detailed kinetic study of methane dehydroaromatization on three bifunctional Mo/HZSM-5 catalysts (0.9 wt.%, 2.7 wt.%, and 17.2 wt. % Mo). Two main deactivation modes are present: (i) irreversible damage by zeolite amorphization during the isothermal pre-treatment in an inert atmosphere and (ii) reversible deactivation by coke deposition (“soft”, “hard” and carbide species). The former occurs at high Mo loading (> 4.0 w%) and provides low activity catalysts. Catalysts with a lower and well-balanced molybdenum loading (< 4 w%) suffer mainly from the second deactivation mode. The catalyst decay is modelled by semi-empirical laws including time on stream and coke level. The latter initiates textural and structural catalyst modifications leading to an activity loss. Three deactivation descriptors, 1: coke level on the spent samples, 2: loss of micropore volume, and 3: monoclinic/orthorhombic phase transition of the zeolite are identified. Further characterization indicates that both molybdenum and carbon species are responsible for the catalytic deactivation of well-balanced catalysts. At least 50% of the initially dispersed molybdenum migrates to the external surface of the zeolite to form large clusters of molybdenum carbide. The coke extracted from the zeolite micropores are confirmed to be mainly unsubstituted polyaromatics.
Thin Film Energy‐Controlled Variable Color Cathodoluminescent Screens (1997)

A new technique for obtaining energy‐variable multicolor cathodoluminescent display screens is presented. This technique employs radio frequency ion plasma sputtering of one thin‐film phosphor material over a dissimilar phosphor substrate. The technique employed differs from the old "Penetron" screen in that the substrate and the secondary phosphor layer are single‐crystal materials. This results in higher resolution and allows the use of lower energy beam excitation. The experiments presented use (red) deposited on a (green) substrate with excitation in the low killovolt range. The method demonstrated, however, is extendable to a full red‐green‐blue triplet composed of a wide variety of materials. The screens are particularly applicable to small, low‐power formats, such as avionics and instrumentation displays.
Effect of the Polymer Backbone on the Thermotropic Behavior of Side-Chain Liquid Crystalline Polymers (1988)

Poly(epichlorohydrin) (PECH) and poly(2,6 - dimethyl-1,4-phenylene oxide) (PPO) containing pendant mesogenic units separated form the main chain through spacers of zero to ten methylene units were synthesized and characterized in order to test the "spacer concept." Both polymers were modified by phase transfer catalyzed esterifications of the chloromethyl groups (PECH) or the bromobenzyl groups (brominated PPO) with potassium ω -(4-oxybiphenyl) alkanoates and potassium ω-(4-methoxy-4′-oxybiphenyl)-alk. an oates. While PPO required ten methylene units as a spacer and 4,4′-methoxybiphenyl as mesogen to present thermotropic liquid crystalline mesomorphism, PECH required no spacer.
Surface property controllable multilayered gate dielectric for low voltage organic thin film transistors (2008)

We report the effects of dielectric surface properties on the device performance of organic thin film transistors (OTFTs) using polymer/high-k oxide multilayered gate dielectrics. We systematically controlled the surface energy of the gate dielectric from very hydrophobic to very hydrophilic. The modified dielectric surface strongly affected the initial growth mechanism of pentacene and subsequently the performance of the OTFTs. The performance of the OTFTs with a higher surface energy was superior to that of the OTFTs with a lower surface energy.
DistAppGaurd: Distributed Application Behaviour Profiling in Cloud-Based Environment (2021)

Today, Machine Learning (ML) techniques are increasingly used to detect abnormal behaviours of industrial applications. Since many of these applications are moving to the cloud environments, classical ML approaches are facing new challenges in accurately identifying abnormal behaviours due to the highly dynamic and heterogeneous nature of the cloud. In this paper, we propose a novel framework, DistAppGaurd, for profiling simultaneously the behaviour of all microservice components of a distributed application in the cloud. The framework can therefore, detect complex attacks that are not observable by monitoring a single process or a single microservice. DistAppGaurd utilizes the system calls executed by all the processes of an application to build a graph consisting of data exchanges among different application entities (e.g., processes and files) representing the behaviour of the application. This representation is then used by our novel miroservice-aware Autoencoder model to perform anomaly detection at runtime. The efficiency and feasibility of our approach is shown by implementing several different real-world attacks, which yields high detection rates (94%-97%) at 0.01% false alarm rate.
Searching in time (2006)

This demonstration shows how to use external databases to provide an efficient implementation of a timetravel service. The timetravel semantics are defined using snapshot isolation. The system presented not only allows to retrieve older snapshots but also to identify snapshots of interest.
Abstract LB-A03: Molecular systems-guided imaging of multicellular in situ adaptation to targeted therapy in BRAF-mutant cancer (2019)

Abstract Adaptive signaling through receptor tyrosine kinases (RTKs) has been highly implicated in the resistance to drugs targeting constitutive RAS/RAF/MEK/ERK signaling, particularly in malignancies with constitutive V600 BRAF mutation. However, it has been difficult to systematically understand how such RTK-mediated bypass signaling is influenced by dynamic and localized interactions between tumor cells and neighboring stromal and immune populations. Here we present a pipeline that combines single-cell and bulk transcriptomic analysis from patients, with systems-level mapping of phosphosignaling pathways in co-cultures, to guide the longitudinal in vivo confocal (intravital) microscopy of adaptive bypass signaling in mouse models of BRAF-mutant cancer. This pipeline prioritizes key myeloid populations and phosphosignaling activities (including of ERK) to image in vivo. Intravital microscopy reveals how therapy-induced myeloid accumulation simultaneously shapes the local activity of multiple co-regulated signaling pathways in neighboring cancer cells, in a RTK-dependent manner. Overall, this work offers an integrative approach to quantitating multiple single-cell signaling pathway activities in the tumor microenvironment, and directly images the dynamics with which known cancer-cell autonomous mechanisms of targeted therapy resistance can be locally amplified by neighboring immune cell populations. Citation Format: Stephanie Wang, Ralph Weissleder, Douglas Lauffenburger, Miles Miller. Molecular systems-guided imaging of multicellular in situ adaptation to targeted therapy in BRAF-mutant cancer [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics; 2019 Oct 26-30; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2019;18(12 Suppl):Abstract nr LB-A03. doi:10.1158/1535-7163.TARG-19-LB-A03
Nanophotonic Metasurfaces for Biosensing and Imaging (2019)

Nanophotonics excels at confining light into nanoscale optical mode volumes and generating dramatically enhanced light matter interactions. These unique aspects have been unveiling a plethora of fundamentally new optical phenomena, yet a critical issue ahead for nanophotonics is the development of novel devices and applications that can take advantage of these nano-scale effects. It is expected that nanophotonics will lead to disruptive technologies in energy harvesting, quantum and integrated photonics, optical computing and including biosensing. To this end, our research is focused on the application of nanophotonics to introduce powerful biosensors that can have impact on a wide range of areas including basic research in life sciences, early disease diagnostics, safety and point-of-care testing. In particular, we exploit nanophotonics and its integration with microfluidics to address key challenges of current biosensors and develop devices that can enable label-free, ultra-sensitive, multiplexed, rapid and real-time measurements on biomolecules, pathogens and living systems. In this talk I will present some of our recent work on nanophotonic meta surfaces for biosensing and bioimaging as well as their applications in real-world settings.
Enhancing Oxygen Reduction Performance of Pt Monolayer Catalysts by Pd(111) Nanosheets on WNi Substrates (2020)

The dissolution of Pd and corrosion of carbon supports may reduce the stability of the Pt monolayer (ML) on Pd-based core catalysts, which will lead to a decrease in their electrocatalytic performances toward the oxygen reduction reaction (ORR). Herein, we report preparation of Pd(111) nanosheets (NS) onto carbon-supported WNi substrates using CO as a reducing and capping agent. Such PdNS/WNi layers can significantly enhance the ORR performance of a PdNS/WNi/C catalyst in alkaline and a PtML/PdNS/WNi/C catalyst in acidic media. The dominating Pd(111) facets and consequently diminished low-coordination sites enhanced their electrocatalytic activity. Meanwhile, the inhibition of Pd–O formation bonds even at 1.1 V due to the presence of WNi/C substrates and additional shape-induced contraction caused by the slight Pd dissolution at the side edges resulted in the improvement in durability. Furthermore, the stability of the carbon supports was improved because of the protection from the well-covered WNi substrates.
p75 nerve growth factor receptor modulates p140trkA kinase activity, but not ligand internalization, in PC12 cells (1994)

The biological activity of nerve growth factor (NGF) has been shown to be mediated by the p140trkA receptor tyrosine kinase, while the role of the p75 NGF receptor (p75NGFR) is still unresolved. Here we have investigated the relative contribution of p140trkA and p75NGFR to early consequences of NGF binding: ligand internalization, p140trkA autophosphorylation, and tyrosine phosphorylation of Shc, phospholipase C gamma-1 (PLC gamma-1), and extracellular signal-regulated kinases (ERKs). It was found that NGF internalization was neither prevented by blocking p140trkA activity using the protein kinase inhibitors methylthioadenosine, staurosporine, and K-252a, nor by inhibiting NGF binding to p75NGFR with antibodies. However, when NGF binding to p140trkA was reduced by the use of a synthetic peptide corresponding to amino acids 36-53 of human p140trkA, internalization of NGF was decreased. Thus, at least in PC12 cells, internalization appears to require binding of NGF to p140trkA, but occurs irrespective of p140trkA kinase activity and ligand occupancy of p75NGFR. The NGF triple mutant Lys-32/Lys-34/Glu-35 to Ala, which has been demonstrated to bind to p140trkA, but not to p75NGFR, induced tyrosine phosphorylation more rapidly than wild-type NGF. Likewise, NGF-induced tyrosine phosphorylation was accelerated when NGF binding to p75NGFR was prevented with REX-IgG. These findings indicate that NGF bindign by p75NGFR may modulate NGF-induced p140trkA kinase activity.
Near-Zero TCF of HAL SAW Resonator with LiTaO<inf>3</inf>-on-Quartz Structure (2018)

This paper reports the recent progress of a new type of hetero acoustic layer (HAL) surface acoustic wave (SAW) resonators using a 0.44 to 1.12 μm thick rotated-Y LiT<;span style="text-transform: lowercase;">a<;/span>O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> (LT) plate and a near ST-cut quartz substrate. This material combination was selected, because quartz has a higher velocity of leaky SAW than LT and a positive temperature coefficient of frequency (TCF). An impedance ratio of 82 dB and a Bode Q of 3, 000 were obtained, and TCFs at series and parallel resonance were measured to be +2 and -10 ppm/PC, respectively. Compared with the characteristics of a standard 42°YX LT SAW resonator fabricated in the same facility, the impedance ratio is higher by 31 dB, the bode Q is 6.3 times higher, and the TCFs at series and parallel resonance are as small as 1/25 and 1/6, respectively.
Calcineurin dephosphorylates Kelch-like 3, reversing phosphorylation by angiotensin II and regulating renal electrolyte handling (2019)

Calcineurin is a calcium/calmodulin-regulated phosphatase known for its role in activation of T cells following engagement of the T cell receptor. Calcineurin inhibitors (CNIs) are widely used as immunosuppressive agents; common adverse effects of CNIs are hypertension and hyperkalemia. While previous studies have implicated activation of the Na-Cl cotransporter (NCC) in the renal distal convoluted tubule (DCT) in this toxicity, the molecular mechanism of this effect is unknown. The renal effects of CNIs mimic the hypertension and hyperkalemia that result from germ-line mutations in with-no-lysine (WNK) kinases and the Kelch-like 3 (KLHL3)-CUL3 ubiquitin ligase complex. WNK4 is an activator of NCC and is degraded by binding to KLHL3 followed by WNK4's ubiquitylation and proteasomal degradation. This binding is prevented by phosphorylation of KLHL3 at serine 433 (KLHL3<sup>S433-P</sup>) via protein kinase C, resulting in increased WNK4 levels and increased NCC activity. Mechanisms mediating KLHL3<sup>S433-P</sup> dephosphorylation have heretofore been unknown. We now demonstrate that calcineurin expressed in DCT is a potent KLHL3<sup>S433-P</sup> phosphatase. In mammalian cells, the calcium ionophore ionomycin, a calcineurin activator, reduces KLHL3<sup>S433-P</sup> levels, and this effect is reversed by the calcineurin inhibitor tacrolimus and by siRNA-mediated knockdown of calcineurin. In vivo, tacrolimus increases levels of KLHL3<sup>S433-P</sup>, resulting in increased levels of WNK4, phosphorylated SPAK, and NCC. Moreover, tacrolimus attenuates KLHL3-mediated WNK4 ubiquitylation and degradation, while this effect is absent in KLHL3 with S433A substitution. Additionally, increased extracellular K<sup>+</sup> induced calcineurin-dependent dephosphorylation of KLHL3<sup>S433-P</sup> These findings demonstrate that KLHL3<sup>S433-P</sup> is a calcineurin substrate and implicate increased KLHL3 phosphorylation in tacrolimus-induced pathologies.
Stevens-Johnson Syndrome Induced by Carbamazepine Treatment in a Patient Who Previously Had Carbamazepine Induced Pruritus - A Case Report - (2013)

Stevens-Johnson syndrome (SJS) is a rare but life-threatening skin reaction disease and carbamazepine is one of its most common causes. We report a case of SJS secondary to carbamazepine in a patient with previous pruritus due to carbamazepine which was given for treatment of trigeminal neuralgia. We would like to caution all providers that carbamazepine readministration should be avoided in the patient with a previous history of SJS or adverse skin reaction. In addition, we strongly recommend gradual titration when initiating treatment with carbamazepine.
Increased number and function of natural killer cells in human immunodeficiency virus 1‐positive subjects co‐infected with herpes simplex virus 2 (2009)

Natural killer (NK) cells bridge the interface between innate and adaptive immunity and are implicated in the control of herpes simplex virus 2 (HSV-2) infection. In subjects infected with human immunodeficiency virus 1 (HIV-1), the critical impact of the innate immune response on disease progression has recently come into focus. Higher numbers of NK cells are associated with lower HIV-1 plasma viraemia. Individuals with the compound genotype of killer cell immunoglobulin-like receptor (KIR) 3DS1 and human leucocyte antigen (HLA)-Bw4-80I, or who have alleles of KIR3DL1 that encode proteins highly expressed on the NK cell surface, have a significant delay in disease progression. We studied the effect of HSV-2 co-infection in HIV-1-infected subjects, and show that HSV-2 co-infection results in a pan-lymphocytosis, with elevated absolute numbers of CD4(+) and CD8(+) T cells, and NK cells. The NK cells in HSV-2 co-infected subjects functioned more efficiently, with an increase in degranulation after in vitro stimulation. The number of NK cells expressing the activating receptors NKp30 and NKp46, and expressing KIR3DL1 or KIR3DS1, was inversely correlated with HIV-1 plasma viral load in subjects mono-infected with HIV-1, but not in subjects co-infected with HSV-2. This suggests that HSV-2 infection mediates changes within the NK cell population that may affect immunity in HIV-1 infection.
CT Detection of Symptomatic and Asymptomatic Meckel Diverticulum (2015)

In patients with known Meckel diverticulum, CT can detect Meckel diverticulum in up to 47.5% of all patients. Meckel diverticulum is more commonly detected in symptomatic patients than in asymptomatic patients, and detection is related to the amount of peritoneal fat.
Incremental Bayesian Audio-To-Score Alignment With Flexible Harmonic Structure Models. (2011)

[TODO] Add abstract here.
A Roadmap to 100G Ethernet at the enterprise data center (2007)

Ethernet networks operating at (100+100) Gb/s per link are showing enough technical and market viability that intense development on technical specifications and component technologies is under way. However, the route to 100 Gb/s Ethernet products is still not completely clear because the market and applications for 100 Gb/s links are quite different than for 1 Gb/s and even 10 Gb/s links. This article attempts to provide a roadmap for adoption of 100 Gb/s Ethernet in enterprise data centers, outlining the features that will affect the schedule, as well as the capabilities of Ethernet gear as it is developed. The major opportunities for 100 Gb/s Ethernet appear to be primarily oriented toward server, rather than desktop/client, applications, and toward interconnecting various types of high- performance computing gear for technical and business analytic computing, as well as for media-oriented and web applications in content development and delivery. These applications will place requirements on the timeline and technical definition of networking gear operating at 40 Gb/s and 100 Gb/s.