gebhart/patrepeval huggingface dataset:
Sulfamethazine Suppresses Epigenetic Silencing in Arabidopsis by Impairing Folate Synthesis (2012)

DNA methylation is a critical, dynamically regulated epigenetic mark. Small chemicals can be valuable tools in probing cellular processes, but the set of chemicals with broad effects on epigenetic regulation is very limited. Using the Arabidopsis thaliana repressor of silencing1 mutant, in which transgenes are transcriptionally silenced, we performed chemical genetic screens and found sulfamethazine (SMZ) as a chemical suppressor of epigenetic silencing. SMZ treatment released the silencing of transgenes as well as endogenous transposons and other repetitive elements. Plants treated with SMZ exhibit substantially reduced levels of DNA methylation and histone H3 Lys-9 dimethylation, but heterochromatic siRNA levels were not affected. SMZ is a structural analog and competitive antagonist to p-aminobenzoic acid (PABA), which is a precursor of folates. SMZ decreased the plant folate pool size and caused methyl deficiency, as demonstrated by reductions in S-adenosylmethionine levels and in global DNA methylation. Exogenous application of PABA or compounds downstream in the folate biosynthesis pathway restored transcriptional silencing in SMZ-treated plants. Together, our results revealed a novel type of chemical suppressor of epigenetic silencing, which may serve as a valuable tool for studying the roles and mechanisms of epigenetic regulation and underscores an important linkage between primary metabolism and epigenetic gene regulation.
Full 360° azimuth angle wideband propagation modeling for an urban line-of-sight microcellular environment (2003)

This paper presents the 360/spl deg/ azimuth angle channel modeling of wideband propagation in urban line-of-sight (LOS) microcellular environment of array antennas at the basestation and its experimental validations. First, the modeling includes rays from the whole 360/spl deg/ azimuth angles. Second, it verifies that the use of three-dimensional and two-dimensional methods in the forward and other reflection and diffraction propagation directions, respectively, is appropriate for the LOS propagation predictions. Third, it includes reflections from the curved surfaces of street corners and walls. Fourth, it extends existing expressions, making them applicable for array antennas at the base station. The results compared with wideband measurements provide better understanding of the propagation mechanism.
HiSCR (Hidradenitis Suppurativa Clinical Response): a novel clinical endpoint to evaluate therapeutic outcomes in patients with hidradenitis suppurativa from the placebo‐controlled portion of a phase 2 adalimumab study (2015)

HiSCR was more responsive to change than HS-PGA Response in this subpopulation.
Impurity contamination in fast-grown KDP (1996)

Potassium dihydrogen phosphate (KDP) has traditionally been used as a nonlinear optical material for frequency conversion to produce second and third harmonic radiation. A high laser induced damage threshold for KDP crystals is required for high power laser applications, such as laser fusion. High quality KDP crystals for such applications can be produced by a recently developed rapid crystal growth method. We report the results of an impurity contamination study in raidlygrown KDP crystals. Using absorption spectroscopy, we identified the impurity contamination in the different growth sectors of the crystals. We show that the level of contamination depends on the growth rate achieved during the rapid growth. The impurities observed by absorption spectroscopy are identified as the origin of lattice distortion and optical birefringence in the KDP crystals. The study of impurity incorporation during crystal growth is important for understanding the damage mechanism of KDP.
Panoramic optical mapping shows wavebreak at a consistent anatomical site at the onset of ventricular fibrillation (2011)

The ARVI is the dominant site for wavebreak at the onset of VF in normal myocardium. This may be due to the anatomic complexity of the region.
Perturbation-based detection and prosthetic correction of vestibulopathic gait (2006)

While being able to balance is something most of us take for granted, each year approximately 400,000 Americans are diagnosed with a balance disorder. In order to prevent fall-related injuries due to postural instability, it is important to create both diagnosis techniques so that therapy can be applied before a fall occurs and devices which can aid the balance-impaired population. The aims of this research are twofold: 1) to develop metrics that quantify the locomotor stability of individuals with reduced vestibular function and 2) to assess the capability of a noninvasive vibrotactile balance prosthesis for improving postural and gait stability. The clinical standards of practice for assessing vestibular deficiency include testing postural stability while standing but not during locomotion. This research examines one
A Method for the Calculation of the AC-Side Admittance of a Modular Multilevel Converter (2018)

Connecting a modular multilevel converter to an ac grid may cause stability issues, which can be assessed by analyzing the converter ac-side admittance in relation to the grid impedance. This paper presents a method for calculating the ac-side admittance of modular multilevel converters, analyzing the main frequency components of the converter variables individually. Starting from a time-averaged model of the converter, the proposed method performs a linearization in the frequency domain, which overcomes the inherent nonlinearities of the converter's internal dynamics and the phase-locked loop used in the control. The ac-side admittance obtained analytically is first validated by simulations against a nonlinear time-averaged model of the modular multilevel converter. The tradeoff posed by complexity of the method and the accuracy of the result is discussed, and the magnitude of the individual frequency components is shown. Finally, experiments on a down-scaled prototype are performed to validate this study and the simplification on which it is based.
δ-EF1 is a negative regulator of Ihh in the developing growth plate (2009)

Indian hedgehog (Ihh) regulates proliferation and differentiation of chondrocytes in the growth plate. Although the biology of Ihh is currently well documented, its transcriptional regulation is poorly understood. delta-EF1 is a two-handed zinc finger/homeodomain transcriptional repressor. Targeted inactivation of mouse delta-EF1 leads to skeletal abnormalities including disorganized growth plates, shortening of long bones, and joint fusions, which are reminiscent of defects associated with deregulation of Ihh signaling. Here, we show that the absence of delta-EF1 results in delayed hypertrophic differentiation of chondrocytes and increased cell proliferation in the growth plate. Further, we demonstrate that delta-EF1 binds to the putative regulatory elements in intron 1 of Ihh in vitro and in vivo, resulting in down-regulation of Ihh expression. Finally, we show that delta-EF1 haploinsufficiency leads to a postnatal increase in trabecular bone mass associated with enhanced Ihh expression. In summary, we have identified delta-EF1 as an in vivo negative regulator of Ihh expression in the growth plate.
Development changes in plasma apoliproteins B and A-I in fetal bovines (1991)

International audience
Limit-Cycle Based Auto-Tuning System for Digitally Controlled Low-Power SMPS (2006)

This paper presents a new method and system for the parameter extraction and dynamic auto-tuning of low power digitally controlled dc-dc switch-mode power supplies (SMPS). During a short-lasting test phase, SMPS parameters, such as output capacitance and load, are estimated by examining the amplitude and frequency of intentionally introduced limit cycle oscillations. Then, accordingly, the digital compensator of SMPS is automatically tuned to improve the output regulation and dynamic performance. The effectiveness of the method is demonstrated on an experimental 200 kHz, 12V-to-5 V, 10 W, digitally controlled buck converter
First Structurally Characterized Palladium(II)‐Substituted Polyoxoanion: [Cs2Na(H2O)10Pd3 (α‐SbIIIW9O33)2] 9‐. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Identification of Novel Inhibitors of Bacterial Translation Elongation Factors (2004)

Bacterial elongation factor Tu (EF-Tu) and EF-Ts are interacting proteins involved in polypeptide chain elongation in protein biosynthesis. A novel scintillation proximity assay for the detection of inhibitors of EF-Tu and EF-Ts, as well as the interaction between them, was developed and used in a high-throughput screen of a chemical library. Several compounds from a variety of chemical series with inhibitory properties were identified, including certain indole dipeptides, benzimidazole amidines, 2-arylbenzimidazoles, N-substituted imidazoles, and N-substituted guanidines. The in vitro activities of these compounds were confirmed in a coupled bacterial transcription-translation assay. Several indole dipeptides were identified as inhibitors of bacterial translation, with compound 2 exhibiting a 50% inhibitory concentration of 14 microM and an MIC for S. aureus ATCC 29213 of 5.6 microg/ml. Structure-activity relationship studies around the dipeptidic indoles generated additional analogs with low micromolar MICs for both gram-negative and gram-positive bacteria. To assess the specificity of antibacterial action, these compounds were evaluated in a metabolic labeling assay with Staphylococcus aureus. Inhibition of translation, as well as limited effects on other macromolecular pathways for some of the analogs studied, indicated a possible contribution from a non-target-based antibacterial mechanism of action.
Expression of DMBT1, a candidate tumor suppressor gene, is frequently lost in lung cancer. (1999)

DMBT1 is a candidate tumor suppressor gene located at 10q25.3-26.1. Homozygous deletion of the gene was found in a subset of medulloblastoma and glioblastoma multiforme; lack of expression was noted in the majority of these tumors. In adult tissues, DMBT1 is highly expressed only in lung and small intestine tissues, indicating its important role in these organs. By analyzing lung cancer cell lines and primary lung tumors using reverse transcription-PCR, we found that 100% (20 of 20) of small cell lung cancer (SCLC) cell lines and 43% (6 of 14) of non-small cell lung cancer (NSCLC) cell lines lacked DMBT1 expression. Furthermore, 45% (9 of 20) of the primary NSCLCs exhibited a markedly low level of gene expression compared with corresponding normal lung tissues, indicating that lack of gene expression also occurs in primary lung cancers. To determine the potential mechanisms for lack of DMBT1 expression in lung cancer, we analyzed tumor cell lines for potential intragenic homozygous deletions of the gene and found such homozygous deletions in 10% (4 of 40) of SCLC cell lines but in none of 14 NSCLC cell lines. Moreover, the loss of expression could not be rescued by treatment with a demethylation agent (5-azacytidine) in two NSCLC cell lines lacking DMBT1 expression, suggesting that de novo methylation of the promoter region of the gene is unlikely to play a role in inactivation of the gene. We then sequenced the whole coding region of DMBT1 in 8 NSCLC cell lines that expressed DMBT1 and 20 primary NSCLCs. A potential point mutation at codon 52 was detected in a NSCLC cell line and resulted in an amino acid change from serine to tryptophan. Three common polymorphisms were also detected in tissues analyzed. Our data demonstrate that DMBT1 expression is frequently lost in lung cancer due to gene deletion and to other not yet identified mechanisms, suggesting that inactivation of DMBT1 may play an important role in lung tumorigenesis.
FAREWELL (2020)

ADVERTISEMENT RETURN TO ISSUEPREVEditorialNEXTFAREWELLCraig W. LindsleyCraig W. LindsleyMore by Craig W. Lindsleyhttp://orcid.org/0000-0003-0168-1445Cite this: ACS Chem. Neurosci. 2020, 11, 24, 3995Publication Date (Web):December 16, 2020Publication History Published online16 December 2020Published inissue 16 December 2020https://pubs.acs.org/doi/10.1021/acschemneuro.0c00717https://doi.org/10.1021/acschemneuro.0c00717editorialACS PublicationsCopyright © 2020 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views961Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (507 KB) Get e-AlertscloseSUBJECTS:Chemical neuroscience,Medicinal chemistry,Neuroscience,Pharmacology,Quality management Get e-Alerts
Data Supplement from MAP Kinase Pathway Alterations in <i>BRAF</i>-Mutant Melanoma Patients with Acquired Resistance to Combined RAF/MEK Inhibition (2023)

&lt;p&gt;PDF file 171K, Contains Supplementary Data and Methods&lt;/p&gt;
Predictive factors and prognostic effect of telomere shortening in pulmonary fibrosis (2018)

Our data indicate that young sporadic IPF patients (<60 years) with some non-specific immunological or haematological abnormalities had higher risk of telomere shortening, and furthermore, they presented a poorer prognosis.
Chlorine-based dry etching ofβ-Ga2O3 (2016)

Reactive ion etching (RIE) and inductively coupled plasma (ICP) etching techniques were used to determine the optimal dry etch conditions for β-Ga2O3. RF power and chamber pressure were examined to study their effects on etch rate and surface roughness for three crystallographic planes, i.e., (100); (010); and ( by RIE. BCl3 etch rate calibrations were performed on all β-Ga2O3 planes studied, in comparison to Cl2. RIE yielded moderate etch rates (<20 nm min−1), and surface roughness showed no clear trend with RF power. Moreover, the effect of bias power, plasma power, and the choice of etchant were studied using ICP. The etches performed by ICP were shown to be superior to RIE in both etch rate and surface roughness, due to the much higher plasma densities and uniformities possible with plasma powers beyond those realized in RIE. The maximum etch rate of 43.0 nm min−1 was achieved using BCl3 in ICP. SF6/BCl3 mixtures, which yield high GaN etch rates, were also studied. However, in contrast to GaN etching, SF6/BCl3 was found to be far less effective than pure BCl3 in etching β-Ga2O3.
Synthesis, Fluorescence, and Two‐Photon Absorption of a Series of Elongated Rodlike and Banana‐Shaped Quadrupolar Fluorophores: A Comprehensive Study of Structure–Property Relationships (2006)

An extensive series of push-push and pull-pull derivatives was prepared from the symmetrical functionalization of an ambivalent core with conjugated rods made from arylene-vinylene or arylene-ethynylene building blocks, bearing different acceptor or donor end-groups. Their absorption and photoluminescence, as well as their two-photon-absorption (TPA) properties in the near infrared (NIR) region, were systematically investigated to derive structure-property relationships and to lay the guidelines for both spectral tuning and amplification of molecular TPA in the target region. Whatever the nature of the core or of the connectors, push-push systems were found to be more efficient than pull-pull systems, and planarization of the core (fluorene versus biphenyl) always leads to an increase in the TPA cross sections. In contrast, increasing the conjugation length as well as replacement of a phenylene moiety by a thienylene moiety in the conjugated rods did not necessarily lead to increased TPA responses. The present study also demonstrated that the topology of the conjugated rods can dramatically influence the TPA properties. This is of particular interest in terms of molecular engineering for specific applications, as both TPA properties and photoluminescence characteristics can be considerably affected. Thus, it becomes possible to optimize the transparency/TPA and fluorescence/TPA efficiency trade-offs for optical limiting in the red-NIR region (700-900 nm) and for two-photon-excited fluorescence (TPEF) microscopy applications, respectively.
LoadIQ: learning to identify workload phases from a live storage trace (2012)

Storage infrastructure in large-scale cloud data center environments must support applications with diverse, time-varying data access patterns while observing the quality of service. Deeper storage hierarchies induced by solid state and rotating media are enabling new storage management tradeoffs that do not apply uniformly to all application phases at all times. To meet service level requirements in such heterogeneous application phases, storage management needs to be phase-aware and adaptive, i.e., to identify specific storage access patterns of applications as they occur and customize their handling accordingly. This paper presents LoadIQ, a novel, versatile, adaptive, application phase detector for networked (file and block) storage systems. In a live deployment, LoadIQ analyzes traces and emits phase labels learnt on the fly by using Support Vector Machines(SVM), a state of the art classifier. Such labels could be used to generate alerts or to trigger phase-specific system tuning. Our results show that LoadIQ is able to identify workload phases (such as in TPC-DS) with accuracy&amp;gt; 93%. 1
ChiMera: an easy to use pipeline for bacterial genome based metabolic network reconstruction, evaluation and visualization (2022)

Overall, ChiMera uses automation algorithms to combine a variety of tools to automatically perform model creation, gap-filling, flux balance analysis (FBA), and metabolic network visualization. ChiMera models readily provide metabolic insights that can aid genetic engineering projects, prediction of phenotypes, and model-driven discoveries.
Prevención del abuso de opioides terapéuticos: Papel del dentista (2011)

Los opiaceos son analgesicos con posibilidad de uso indebido, abuso o adiccion (potencial de abuso). Se estima que hasta un 23% de las dosis prescritas se utilizan con fines no medicos. Como prescriptores del 12% de lo opioides de liberacion inmediata (LI) en los Estados Unidos, los dentistas pueden minimizar el potencial de abuso.
Los autores participaron en una reunion de dos dias en marzo de 2010, copatrocinada por el Programa de Gestion de Riesgos de Opioides del Instituto Tufs, Boston y por la Facultad ed Medicina Dental de la Universidad Tufs, Boston. El proposito de la reunion fue sintetizar la literatura disponible sobre abuso de opioides y los datos de una encuesta realizada en 2010 en Virginia Occidental sobre las practicas de prescripcion de analgesicos de los dentistas, determinando el papel que desempenan los dentistas en las prescripcion de los opioides que se utilizan con fines no medicos, senalando las medidas que los dentistas pueden poner en practica e identificando las limitaciones de la investigacion.
Los dentistas pueden contribuir a reducir el consumo a traves de la educacion del paciente, la evaluacion cuidadosa del mismo y su derivacion para el tratamiento del abuso de sustancias cuando este indicado, asi como usando herramientas tales como los programas de vigilancia de la prescripcion. Se necesita investigacion adicional para determinar el numero optimo de dosis necesarias para tratar el dolor relacionado con la odontologia.
los autores animas a los dentistas a incorporar medidas practicas de salvaguarda cuando recetan opioides, a educar a sus pacientes acerca de como deshacerse de los opioides sobrantes, a investigar la presencia de trastorno por consumo de sustancias y a desarrollar una red de derivacion para el tratamiento de estos trastornos.
Relationships Between the Axial Derotation of the Lower Instrumented Vertebra and Uninstrumented Lumbar Curve Correction: Radiographic Outcome in Lenke 1 Adolescent Idiopathic Scoliosis With a Minimum 2-Year Follow-up (2018)

The relationship between LIV rotation correction and spontaneous lumbar curve correction after selective thoracic fusion varied based on the patient's 3D preoperative curve characteristics. Patients with lumbar modifier C and apical vertebrae translation ratios >1.5 showed improved lumbar Cobb correction in 2-years when 50% or more LIV rotation correction was achieved surgically.
2 30W TWTA Power supply design (1985)

The electronic power conditioner (EPC) design for 230W RF 12 GHz TWTs is presented. Particular emphasis is devoted in evidencing the bus and tube interface problems, the technological aspects versus the very severe environmental requirements and the protection philosophy. In fact the EPC has to handle a very high power (~600 W), to provide outputs voltages up to 7.5 KV, to guarantee high stability of output parameters inside a very large operating temperature range (-35°C / +70°C). The major problems encountered during the development, the followed approaches and the main obtained results are outlined.
Supplementary Tables S1-14 from Genetic Heterogeneity and Tissue-specific Patterns of Tumors with Multiple <i>PIK3CA</i> Mutations (2023)

&lt;p&gt;Table S1: Clinico-demographic characteristics of single- and multi-PIK3CA mutant tumors; Table S2: Prevalence of single and multi-PIK3CA mutated tumors across all tumor types; Table S3: Prevalence of single and multi-PIK3CA mutated tumors across pan-tumor histological subtypes; Table S4: Prevalence of single and multi-PIK3CA mutated tumors in different receptor subgroups of breast cancer; Table S5: Clonality predictions for double PIK3CA mutated tumors in different tumor types; Table S6: Prediction of cis/trans orientation for double PIK3CA mutated tumors in different tumor types; Table S7: Patterns of co-occurrence and mutual exclusivity between multi-PIK3CA mutations and other gene alterations in the overall cohort and specific tumor types; Table S8: Comparison of co-occurring alterations in multi-PIK3CA and single-PIK3CA mutant tumors; Table S9: Prevalence of multi-PIK3CA mutations based on status of tumor mutational burden; Table S10: Breakdown of PIK3CA mutations in different classes of mutational signatures in patients with a high tumor mutational burden; Table S11: Prevalence of single- and multi-PIK3CA mutations based on tumor mutational burden and APOBEC signatures; Table S12: Prevalence of specific pairs of PIK3CA mutations across different tumor types; Table S13: Prevalence of specific pairs of PIK3CA mutations at the codon level, across different tumor types; Table S14: Codon enrichment between single and multi-PIK3CA mutant tumors across different tumor types.&lt;/p&gt;
Tin in Organic Synthesis (2008)

This chapter contains sections titled: Applications of Organotin Derivatives for Carbohydrate Synthesis Reactions of SE′ Substitution for Organostannanes in Organic Synthesis Cross-Coupling of Organotin Compounds for CarbonCarbon Bond Formation Stille Cross-Coupling for the Synthesis of Natural Products New Trends in the Synthesis of Solid-Supported Organotin Reagents and Interest of their Use in Organic Synthesis in a Concept of Green Chemistry Palladium-Catalyzed Cascade Cyclization-Anion Capture Processes Employing Pre- and In Situ-Formed Organostannanes Carbostannylation of CarbonCarbon Unsaturated Bonds Green Organotin Chemistry: an Oxymoron?