gebhart/patrepeval huggingface dataset:
Abstract 1555: Monoclonal antibodies targeting the TAM family of receptor tyrosine kinases (2019)

Abstract The TAM receptors (Tyro3/Axl/MerTK) family of receptor tyrosine kinases (RTKs) are important negative regulators of innate immunity. TAM receptor activation in myeloid cells by its ligands Gas6 or Protein S (PROS) promotes phosphatidylserine-dependent efferocytosis of apoptotic cells, inducing a tolerogenic state and mediating resolution of inflammation. TAM-deficient mice exhibit phenotypes consistent with systemic inflammation and autoimmunity. Importantly, individual ablation of TAM receptors can confer tumor immunity, increased pro-inflammatory cytokines and tumor lymphocyte infiltration, leading to the proposal that TAM receptors act as checkpoints of innate immunity. We hypothesize that pharmacological targeting of this family of receptors with monoclonal antibodies (mAbs) may lead to a similar pro-inflammatory response and recapitulate the antitumor effects observed in TAM-deficient mice. From a panel of human anti-MerTK, Axl or Tyro3 mAbs derived from phage-display libraries or human IgG expressing mice we identified unique mAbs that markedly enhanced cytokine and chemokine release from primary human immune cells, alone or in the presence of inflammatory stimuli. Interestingly, the qualitative and quantitative pattern of cytokine response from dendritic cells was very similar using antibodies targeting the individual TAM receptors, and also similar to activation of dendritic cells using a CD40 agonist mAb, suggesting that TAM-targeting mAbs can promote immune activation. We identified surrogate mAbs targeting mouse TAM receptors that elicited similar responses in vivo, and demonstrated antitumor activity when dosed alone, or in combination with PD-1/L1 blockade in syngeneic tumor models. In addition, human MerTK transgenic, and TAM knockout mice have been generated and characterized in order to establish in vivo proof-of-concept with human TAM mAbs. Overall, pharmacological modulation of TAM receptors with mAbs enhances cytokine production in human and murine model systems consistent with the published role of TAMs as negative regulators of innate immunity. Mechanistic and proof-of-concept studies support further development of these mAbs as novel approaches to overcome these checkpoints of the innate immune response. Citation Format: Diego Alvarado, Laura Vitale, Mike Murphy, Thomas O'Neill, Andrew Proffitt, Jay Lillquist, Gwenda Ligon, Komal Patel, Anna Wasiuk, Jeff Weidlick, Jenifer Widger, Laura Mills-Chen, Andrea Crocker, Colleen Patterson, Russell A. Hammond, Li-Zhen He, Joel Goldstein, Lawrence J. Thomas, Henry C. Marsh, Tibor Keler, Richard Gedrich. Monoclonal antibodies targeting the TAM family of receptor tyrosine kinases [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1555.
Data from Dysregulation of EGFR Pathway in EphA2 Cell Subpopulation Significantly Associates with Poor Prognosis in Colorectal Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; EphA2 receptor is involved in multiple cross-talks with other cellular networks, including EGFR, FAK, and VEGF pathways, with which it collaborates to stimulate cell migration, invasion, and metastasis. Colorectal cancer (CRC) EphA2 overexpression has also been correlated to stem-like properties of cells and tumor malignancy. We investigated the molecular cross-talk and miRNAs modulation of the EphA2 and EGFR pathways. We also explored the role of EphA2/EGFR pathway mediators as prognostic factors or predictors of cetuximab benefit in patients with CRC.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Gene expression analysis was performed in EphA2&lt;sub&gt;high&lt;/sub&gt; cells isolated from CRC of the AOM/DSS murine model by FACS-assisted procedures. Six independent cohorts of patients were stratified by EphA2 expression to determine the potential prognostic role of a EphA2/EGFR signature and its effect on cetuximab treatment response.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; We identified a gene expression pattern (&lt;i&gt;EphA2&lt;/i&gt;, &lt;i&gt;Efna1&lt;/i&gt;, &lt;i&gt;Egfr&lt;/i&gt;, &lt;i&gt;Ptpn12&lt;/i&gt;, and &lt;i&gt;Atf2&lt;/i&gt;) reflecting the activation of EphA2 and EGFR pathways and a coherent dysregulation of mir-26b and mir-200a. Such a pattern showed prognostic significance in patients with stage I–III CRC, in both univariate and multivariate analysis. In patients with stage IV and WT KRAS, &lt;i&gt;EphA2&lt;/i&gt;/&lt;i&gt;Efna1&lt;/i&gt;/&lt;i&gt;Egfr&lt;/i&gt; gene expression status was significantly associated with poor response to cetuximab treatment. Furthermore, EphA2 and EGFR overexpression showed a combined effect relative to cetuximab resistance, independently from KRAS mutation status.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; These results suggest that &lt;i&gt;EphA2&lt;/i&gt;/&lt;i&gt;Efna1&lt;/i&gt;/&lt;i&gt;Egfr&lt;/i&gt; genes, linked to a possible control by miR-200a and miR-26b, could be proposed as novel CRC prognostic biomarkers. Moreover, EphA2 could be linked to a mechanism of resistance to cetuximab alternative to KRAS mutations. &lt;i&gt;Clin Cancer Res; 23(1); 159–70. ©2016 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Preparation and immunogenicity of a purified influenza virus haemagglutinin and neuraminidase subunit vaccine (1976)

Summary A vaccine was prepared containing the haemagglutinin and neuraminidase subunits from the A/Port Chalmers. 1/73 (H3N2) strain of influenza virus. The virus particles were disrupted with ammonium deoxycholate and the matrix protein, which was insoluble in this detergent, was removed by centrifugation. Following removal of deoxycholate, the haemagglutinin and neuraminidase subunits aggregated by their hydrophobic ends, forming mixed clusters. These were then freed from nucleocapsids by electrophoresis. The haemagglutinin and neuraminidase subunits were as effective as intact inactivated virus (at equivalent concentration) in eliciting a late primary antibody response when injected in saline into rabbits. In humans also, the subunits were as immunogenic as intact inactivated virus particles at equivalent concentration. Many people, however, responded only to the ‘common’ antigenic determinant(s) on the haemagglutinin subunit of Port Chalmers/73 virus and did not respond at all to the ‘specific’ determinant(s). Sera from these people contained antibodies which reacted equally as well with Hong Kong/68 virus as with the Port Chalmers/73 strain and none which reacted exclusively with the latter virus.
Effect of radical species density and ion bombardment during ashing of extreme ultralow-κ interlevel dielectric materials (2007)

The significance of ion impact and radical species density on ash-induced modification of an extreme ultralow-κ interlevel dielectric (ILD) material (κ&amp;lt;2.0) in a patterned single damascene structure exposed to Ar∕O2 and Ar∕N2 dual frequency capacitive discharges is determined by combining plasma diagnostics, modeling of the ion angular distribution function, and material characterization such as angle resolved x-ray photoelectron spectroscopy. Radical species density was determined by optical emission actinometry under the same conditions and in the same reactor in a previous study by the present authors. ILD modification is observed and correlated with changes in the plasma for a range of pressures (5–60mTorr), bias powers (0–350W), and percent Ar in the source gas (0%, 85%). For the Ar∕O2 discharge, extensive modification of the ILD sidewall was observed for significant ion scattering conditions, whereas minimal modification of the ILD sidewall was observed under conditions of minimal or no ion scattering. Further, for an identical increase in the O-radical density (∼ an order of magnitude), a different degree of modification was induced at the ILD trench bottom surface depending on whether pressure or percent Ar was used to increase the radical density. The different degrees of modification seemingly correlated with the relative changes in the ion current for increasing pressure or percent Ar. For the Ar∕N2 discharge, reduced damage of the ILD sidewall and trench bottom surfaces was observed for increasing pressure (increasing N-radical density) and decreasing ion current to both surfaces. It is, thus, proposed that the mechanism for modification of the porous ILD is dominated by the creation of reactive sites by ion impact under the present conditions. A detailed discussion of the results which support this proposal is presented.
Separation-Free Super-Resolution from Compressed Measurements is Possible: an Orthonormal Atomic Norm Minimization Approach (2017)

We consider the problem of recovering the superposition of $R$ distinct complex exponential functions from compressed non-uniform time-domain samples. Total Variation (TV) minimization or atomic norm minimization was proposed in the literature to recover the $R$ frequencies or the missing data. However, it is known that in order for TV minimization and atomic norm minimization to recover the missing data or the frequencies, the underlying $R$ frequencies are required to be well-separated, even when the measurements are noiseless. This paper shows that the Hankel matrix recovery approach can super-resolve the $R$ complex exponentials and their frequencies from compressed non-uniform measurements, regardless of how close their frequencies are to each other. We propose a new concept of orthonormal atomic norm minimization (OANM), and demonstrate that the success of Hankel matrix recovery in separation-free super-resolution comes from the fact that the nuclear norm of a Hankel matrix is an orthonormal atomic norm. More specifically, we show that, in traditional atomic norm minimization, the underlying parameter values $\textbf{must}$ be well separated to achieve successful signal recovery, if the atoms are changing continuously with respect to the continuously-valued parameter. In contrast, for the OANM, it is possible the OANM is successful even though the original atoms can be arbitrarily close. As a byproduct of this research, we provide one matrix-theoretic inequality of nuclear norm, and give its proof from the theory of compressed sensing.
Structural determination and synthesis of a chemical signal of the male state and a potential multipurpose pheromone of the mouse Mus musculus (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructural determination and synthesis of a chemical signal of the male state and a potential multipurpose pheromone of the mouse Mus musculusDonald P. Wiesler, Frank J. Schwende, Marvin Carmack, and Milos NovotnyCite this: J. Org. Chem. 1984, 49, 5, 882–884Publication Date (Print):March 1, 1984Publication History Published online1 May 2002Published inissue 1 March 1984https://pubs.acs.org/doi/10.1021/jo00179a025https://doi.org/10.1021/jo00179a025research-articleACS PublicationsRequest reuse permissionsArticle Views141Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Filamentation-Free Broad-Area Laser Design for Efficient Coupling to Single-Mode Fiber (2014)

Although the quest for high-power, diffraction-limited, semiconductor lasers has arguably met with limited success, the drive for higher brightness diode lasers continues, driven by fiber laser systems. Using tailored refractive-index and injection-current profiles, broad-area laser beam propagation method simulations predict simultaneous suppression of free-carrier-induced self-focusing and far-field mode compression at high powers. Asymmetric gain from tailored current profiles generate unconventional, null-less modes and lead to distributed gain- and loss-filtering mechanisms for increased beam quality output. A 5.2-7.7 W of filament-free power enables high-efficiency (70%) coupling into SMF-28, resulting in 3.1-5.5 W of fiber-coupled power for erbium-doped fiber amplifiers pumping with 0.72-W/A slope efficiency. The concept is shown to be robust against the shape of the profiles, inhomogeneities in both injection current and refractive index, and thermal lensing with proper submount design.
Remarks from the Honorable Joseph P. Kennedy II, Massachusetts 8th district, The United States House of Representatives, Washington, DC (2009)

Aging Services Programs, for inviting me to speak to you today.I would also like to recognize NestlC, the Clintec Nutrition Company, the Administration on Aging, and the National Association of State Units for making this conference possible.No one knows better than those of you gathered today the value of a hot lunch or a home-delivered meal for a senior citizen.You all are on the forefront of providing nutrition care services to America's senior citizens.You are the experts who are developing the cutting-edge techniques for detecting malnutrition in the elderly.You are the leaders in coordinating services for seniors at the state level, and especially in rural communities.We are indebted to you for your commitment to improving the lives of older Americans.Right now, you are sitting down to lunch.The fact is that for most of us, getting lunch is not a problem.We take for granted being able to go to the grocery store, cook our own meals, or even pay the price of food.But that is not the case for millions of senior citizens.They are worried about how they will get or prepare their next meal.Best estimates indicate that somewhere between 2.5 and 4.9 million seniors are hungry or are worried about having enough food to eat.Today, the federal congregate nutrition program provides about 125 million hot meals to 2.4 million older Americans in settings in their own communities, such as churches and senior centers all across the country.In addition, the federal Meals-on-Wheels program provides about 100 million meals to about 800,000 seniors who are homebound.Many who reap the benefits of this program have
ChemInform Abstract: Nucleophilic Substitution of the Hydroxyl Group in Stereogenic Alcohols with Chirality Transfer. (2016)

Abstract An intramolecular substitution of the OH group in enantioenriched alcohols is achieved by acid/base bifunctional catalysis.
Combustion Noise in a Flameless Trapped-Vortex Reheat Burner (FTVRB) (2007)

The combustion characteristics of a FTVRB with multiple cavity air jets were investigated, including premix flame stabilization, emissions, flame location, flow dynamics and combustion oscillations. Special focus was given to the response of the cavity flame structure and emissions to various injections, resulting in dierent cavity swirl structures. PIV measurements were conducted to visualize the interaction of the main flow with the cavity recirculation pattern. At certain operating conditions the cavity pilot flame was susceptible to the onset of combustion oscillations in pressure and heat release. For an air injection pattern with high oscillation amplitudes, thermoacoustic stability analysis was used to verify that the system was linearly unstable. Models for the linear response were determined by using a phase-shift controller to suppress the instability.
Chimpanzee SIV Envelope trimer: structure and deployment as an HIV vaccine template (2018)

Summary Epitope-targeted HIV vaccine design seeks to focus antibody responses to broadly neutralizing antibody (bnAb) sites by sequential immunization. Chimpanzee SIV Envelope (Env) shares a single bnAb site, the V2-apex, with HIV, suggesting its possible utility in an HIV immunization strategy. Accordingly, we generated a chimpanzee SIV Env trimer, MT145K, which displays selective binding to HIV V2-apex bnAbs and precursor versions, but no binding to other HIV specificities. We determined the structure of the MT145K trimer by cryo-EM and showed its architecture was remarkably similar to HIV Env. Immunization of an HIV V2-apex bnAb precursor Ab-expressing knock-in mouse with chimpanzee MT145K trimer induced HIV V2-specific neutralizing responses. Subsequent boosting with an HIV trimer cocktail induced responses exhibiting some virus cross-neutralization. Overall, the chimpanzee MT145K trimer behaves as expected from design both in vitro and in vivo and is an attractive potential component of a sequential immunization regimen to induce V2-apex bnAbs.
Outcome of surgical resection of pulmonary metastasis from urinary tract transitional cell carcinoma (2010)

There is little information on pulmonary metastasectomy of urinary tract transitional cell carcinoma (TCC). In this study, we examined the long-term outcome and the factors associated with long-term survival after pulmonary metastasectomy of urinary tract TCC based on a 20-year single center experience. Between 1984 and 2005, 18 patients (12 men, six women) underwent pulmonary metastasectomy of the urinary tract TCC in our hospital. The clinicopathological and surgical data of these patients obtained from the medical records were analyzed in this retrospective study. The time interval between lung resection and death, or latest follow-up ranged from two to 200 months (median 52). Survival analysis was conducted by the Kaplan-Meier method and log-rank test. The cumulative three- and five-year survival rates were 59.8% and 46.5%, respectively. The number of resected metastatic tumors (solitary vs. multiple) was associated with long-term survival (P<0.05). The five-year survival rate of patients with solitary metastasis was 85.7% while that of patients with multiple metastases was 20.0%. Pulmonary metastasectomy of urinary tract TCC is associated with a favorable outcome, and solitary metastasis is associated with long-term survival. Aggressive management of solitary pulmonary metastasis from a urinary tract TCC is feasible in selected patients.
Two-way TCP performance issues and solutions in asymmetric LTE radio access (2014)

Due to the joint evolution of mobile applications and cloud services, mobile users routinely act as both content consumers and producers. Nowadays there is an increasing trend in both the downlink (DL) and uplink (UL) data traffic, which are predominantly Transmission Control Protocol (TCP) based. Simultaneous DL and UL TCP transmission over an asymmetric link causes significant throughput degradation in the direction with higher capacity whenever TCP data and acknowledgment (ACK) segments are not treated separately. The radio access links of the Long Term Evolution (LTE) systems are asymmetric with higher capacity in the DL than in UL, making LTE prone to the asymmetry problem. In this context, the degradation is caused by multiplexing data and ACKs in the same User Equipment (UE) buffer before UL transmission. This paper proposes and evaluates three novel alternatives that solve the problem at the network side, i.e., transparently to the end devices. Simulation results indicate that the solutions can efficiently detect and resolve the asymmetry problem and they are able to reach the theoretical optimum within 1-5%. Excellent performance is provided even in the presence of complex web traffic.
Supported Organometallics. Highly Electrophilic Cationic Metallocene Hydrogenation and Polymerization Catalysts Formed via Protonolytic Chemisorption on Sulfated Zirconia (1998)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTSupported Organometallics. Highly Electrophilic Cationic Metallocene Hydrogenation and Polymerization Catalysts Formed via Protonolytic Chemisorption on Sulfated ZirconiaHongsang Ahn and Tobin J. MarksView Author Information Department of Chemistry, Northwestern University Evanston, Illinois 60208-3113 Cite this: J. Am. Chem. Soc. 1998, 120, 51, 13533–13534Publication Date (Web):December 30, 1998Publication History Received20 July 1998Published online30 December 1998Published inissue 1 December 1998https://pubs.acs.org/doi/10.1021/ja9825682https://doi.org/10.1021/ja9825682rapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views833Altmetric-Citations61LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Adsorption,Catalysts,Hydrocarbons,Hydrogenation,Oxides Get e-Alerts
Families of bacterial signal‐transducing proteins (1989)

Bacteria can respond to a variety of environmental stimuli by means of systems generally composed of two proteins. The first protein (sensor or transmitter) is usually a transmembrane protein with cytoplasmic and extracytoplasmic domains. The extracytoplasmic domain (sensor) senses the environment and transfers the signal through the transmembrane domain to the cytoplasmic domain (transmitter), which has kinase activity. The second protein is located in the cytoplasm and contains an amino-terminal domain (receiver), which can be phosphorylated by the transmitter, and a carboxy-terminal region (regulator), which regulates gene expression by binding to DNA. The transmitter and receiver modules (the kinase and its target) are conserved in all signal-transducing systems and are the 'core structure' of this two-component system. The sensors and the regulators vary according to the stimuli they respond to and the DNA structure they interact with. On the basis of their sequence homology, the proteins belonging to such two-component systems can be classified into different families, which are summarized in this review.
Neurological complications of sepsis (2023)

In this manuscript, we provide an overview of recent insights and developments in the prevention, diagnosis, and treatment of patients with SAE and ICUAW.
Fracture Healing Effects of Locally-Administered Adipose Tissue-Derived Cells (2015)

Enhanced bone density in the implant area suggests that ADCs have fracture-healing effects.