gebhart/patrepeval huggingface dataset:
Learning to learn: Non-equilibrium design protocols for adaptable materials (2022)

Evolution in time-varying environments naturally leads to adaptable biological systems that can easily switch functionalities. Advances in the synthesis of environmentally-responsive materials therefore open up the possibility of creating a wide range of synthetic materials which can also be trained for adaptability. We consider high-dimensional inverse problems for materials where any particular functionality can be realized by numerous equivalent choices of design parameters. By periodically switching targets in a given design algorithm, we can teach a material to perform incompatible functionalities with minimal changes in design parameters. We exhibit this learning strategy for adaptability in two simulated settings: elastic networks that are designed to switch deformation modes with minimal bond changes; and heteropolymers whose folding pathway selections are controlled by a minimal set of monomer affinities. The resulting designs can reveal physical principles, such as nucleation-controlled folding, that enable adaptability.
Polyethylenimine/small interfering RNA‐mediated knockdown of vascular endothelial growth factor in vivo exerts anti‐tumor effects synergistically with Bevacizumab (2010)

PEI F25-LMW/siRNA complexes, which can be stored frozen as opposed to many other carriers, represent an efficient, safe and promising avenue in anti-tumor therapy, and PEI/siRNA-mediated, therapeutic VEGF knockdown exerts anti-tumor effects.
Measuring the equation of state of the universe: Pitfalls and prospects (2002)

We explore various pitfalls and challenges in determining the equation of state $(w)$ of the dark energy component that dominates the universe and causes the current accelerated expansion. We demonstrated in an earlier paper the existence of a degeneracy that makes it impossible to resolve well the value of w or its time derivative with supernovae data. Here we consider standard practices, such as assuming that w is constant or greater than $\ensuremath{-}1,$ and show that they also can lead to gross errors in estimating the true equation of state. We further consider combining measurements of the cosmic microwave background anisotropy and the Alcock-Paczynski test with supernovae data and find that the improvement in resolving the time derivative of w is marginal, although the combination can constrain its present value perhaps to 20% uncertainty.
The Newtonian Gravitational Constant: An index of measurements (1987)

The Newtonian Gravitational Constant, G, has probably been measured more often but, interestingly, with less precision than any other physical constant of fundamental importance. In an effort that has spanned more than a century to connect gravitation to the other forces of nature, over 200 experiments on G have been completed and reported; but many of them have not been reported in what would now be considered to be the open literature. This paper is a third, more complete attempt to carry MacKenzie's and Poynting's bibliographies forward from the 1800's to the present; and thereby include as many as possible of the experimental results on G that have been obtained since 1900.
Derivation of the refraction equations for higher-order aberrations of local wavefronts at oblique incidence (2010)

From the literature the calculation of power and astigmatism of a local wavefront after refraction at a given surface is known from the vergence and Coddington equations. For higher-order aberrations (HOAs) equivalent analytical equations do not exist. Since HOAs play an increasingly important role in many fields of optics, e.g., ophthalmic optics, it is the purpose of this study to extend the "generalized Coddington equation" to the case of HOA (e.g., coma and spherical aberration). This is done by local power series expansions. In summary, with the results presented here, it is now possible to calculate analytically the local HOA of an outgoing wavefront directly from the aberrations of the incoming wavefront and the refractive surface.
Study on carbapenemase-producing bacteria by matrix-assisted laser desorption/ionization approach (2021)

The development of new techniques for the detection of carbapenemase activity is of great importance since the increased incident of resistance against carbapenems represents a serious threat to global public health. In this context, the matrix-assisted laser desorption/ionization approach already demonstrated to be a reliable tool for rapid carbapenemase detection. As a newly developed test, there is still a lack of in-depth analysis of its robustness and possible wider application. The main goal of this study was to evaluate the potential for using the design MBT STAR-Carba assay as the pre-characterization method for Enterobacterales and P. aeruginosa strains in terms of the produced classes of carbapenemases using modified procedure parameters-various suspension densities and incubation times. Moreover, its usefulness for the in-depth analysis and characterization of metallo-β-lactamases (MBL) was tested by applying inhibition assays. In this study, the designed assay proved to be a sensitive tool for the detection of carbapenemase hydrolytic activity, which can be successfully used to partially classify the class of carbapenemase present. Additionally, the use of defined high concentration suspensions would allow to shorten the incubation time to 1 minute for certain strains. Considering that the assay was also suitable to investigate the effect of different inhibitors on the MBL activity, it demonstrates far higher discriminatory potential than only a rapid routine carbapenemase detection tool and could be used as a susceptibility assay.
The two‐component response regulator PprB modulates quorum‐sensing signal production and global gene expression in Pseudomonas aeruginosa (2005)

The response regulator PprB and its cognate sensor PprA were recently reported as a two-component regulatory system that controls membrane permeability and antibiotic sensitivity of Pseudomonas aeruginosa. We found that a Tn5 insertion mutation in pprB caused a drastic reduction in virulence factor production and cell motility. A transcriptome analysis revealed that 175 genes were regulated by PprB. Among the 113 PprB-activated genes, 85.5% are known to be activated by N-3-oxo-dodecanoyl-homoserine lactone (OdDHL) and N-butanoyl-homoserine lactone (BHL). In particular, the expression of lasI, rhlI and rhlR, which encode key components of the las and rhl quorum-sensing (QS) systems, were significantly decreased in the pprB mutant. These data suggest that PprB might regulate QS signal production. Measurement of OdDHL and BHL in cultures of the mutant sustained this hypothesis. By using various OdDHL- or BHL-responsive QS reporter systems, including lasB-lacZ, lasI-lacZ and rsaL-lacZ, we found that the mutation in pprB resulted in a large decrease in the sensitivity of P. aeruginosa to exogenous OdDHL. However, there was no difference in sensitivity to BHL. Further analysis showed that the OdDHL influx was significantly reduced in the pprB mutant. We conclude that PprB is a novel QS modulator that positively regulates N-acylhomoserine lactone production probably by affecting the OdDHL signal influx and thereby influences global expression of the QS-dependent genes.
Gas phase selective propylene epoxidation over La2O3-supported cubic silver nanoparticles (2019)

It is shown that the Ag nanocube/La<sub>2</sub>O<sub>3</sub> interface catalyses gas phase oxidation of propylene to propylene oxide cooperatively with enhanced selectivity and conversion. Dioxygen is preferentially activated and dissociated by La<sub>2</sub>O<sub>3</sub>(001) and the active atomic oxygen over the Ag(100) facet leads to selective propylene epoxidation.
In vitro inhibition of Enterococcus cecorum by probiotic Bacillus strains (2016)

International audience
Efficient three dimensional modelling of additive manufactured textiles (2013)

Purpose The purpose of this paper is to investigate, develop and validate a three‐dimensional modelling strategy for the efficient generation of conformal textile data suitable for additive manufacture. Design/methodology/approach A series of additive manufactured (AM) textiles samples were modelled using currently available computer‐aided design software to understand the limitations associated with the generation of conformal data. Results of the initial three‐dimensional modelling processes informed the exploration and development of a new dedicated efficient modelling strategy that was tested to understand its capabilities. Findings The research demonstrates the dramatically improved capabilities of the developed three‐dimensional modelling strategy, over existing approaches by accurately mapping complex geometries described as STL data to a mapping mesh without distortion and correctly matching the orientation and surface normal. Originality/value To date the generation of data for AM textiles has been seen as a manual and time‐consuming process. The research presents a new dedicated methodology for the efficient generation of complex and conformal AM textile data that will underpin further research in this area.
Table S1 from Enrichment of PI3K-AKT–mTOR Pathway Activation in Hepatic Metastases from Breast Cancer (2023)

&lt;p&gt;Tumor percentage for specimens undergoing exome sequencing.&lt;/p&gt;
S580 SARS-CoV2 Testing Prior to Endoscopy: Discrepancy Between Estimated and True Asymptomatic Prevalence Rates in a Community-Based Gastroenterology Practice (2021)

Introduction: The novel coronavirus 2019 (COVID-19) pandemic has limited endoscopic utilization causing significant health and economic burdens. Gastroenterology (GI) societies recommended COVID-19 testing of all patients undergoing endoscopy. The American Gastroenterological Association (AGA) later provided an updated guidance on implementing pre-testing strategy based on an estimated asymptomatic prevalence within a certain state or county. Most recently, the AGA recommended stopping pre-endoscopy COVID-19 testing due to little benefit of routine testing and very low rates of infection among patients and staff. We compared the difference between the true and estimated asymptomatic prevalence of COVID-19 in patients undergoing endoscopy at our community-based GI practice. Methods: This is a clinical, observation-based quality initiative of patients scheduled for endoscopic procedures at our community-based GI practice from May-December, 2020. All patients underwent symptom screening, followed by polymerase chain reaction (PCR) testing. True COVID-19 asymptomatic prevalence at our practice was calculated (total number of asymptomatic PCR-positive cases divided by the total number of scheduled procedures). Estimated asymptomatic prevalence was determined based on the AGA calculation (number of new cases in the past 2 weeks within the practice’s county multiplied by 10 and then divided by the county’s population). Asymptomatic prevalence was reported as low (<0.5%), intermediate (0.5-2%), or high (>2%). Results: A total of 11,542 endoscopic procedures were performed between May-December, 2020. Based on the true asymptomatic prevalence, our practice remained a low-prevalence area in May-October, intermediate in November, and high in December. Estimated asymptomatic prevalence based on the AGA calculation placed our practice in a low-prevalence area in May-June, intermediate in July-September and high in October-December. None of the providers developed COVID-19 after the procedures. Conclusion: There is a clear discrepancy between our practice’s true COVID-19 asymptomatic prevalence which was lower than the estimated asymptomatic prevalence using the AGA calculation. That, in combination with the low patient-provider infection rate and the potential delays in care and patient burdens associated with pre-endoscopy testing affirms the latest AGA guidance that COVID-19 testing prior to endoscopy is no longer needed to perform endoscopy safely.Figure 1.: Panel A: True Asymptomatic Prevalence for the Practice by Month. Panel B: Estimated Asymptomatic Prevalence for the Practice’s County by Month.
80: Time-Point Study of the Regulation of Nuclear Protein SM-22 (Transgelin) in the Rat Cystitis Model (2005)

You have accessJournal of UrologyModerated Poster, Saturday, May 21, 2005 1:00 - 3:00 pm1 Apr 200580: Time-Point Study of the Regulation of Nuclear Protein SM-22 (Transgelin) in the Rat Cystitis Model Thu-Suong Van Le, Yukio Hayashi, Shachi Tyagi, Naoki Yoshimura, Michael B. Chancellor, and Fernando de Miguel Thu-Suong Van LeThu-Suong Van Le More articles by this author , Yukio HayashiYukio Hayashi More articles by this author , Shachi TyagiShachi Tyagi More articles by this author , Naoki YoshimuraNaoki Yoshimura More articles by this author , Michael B. ChancellorMichael B. Chancellor More articles by this author , and Fernando de MiguelFernando de Miguel More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)34345-3AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "80: Time-Point Study of the Regulation of Nuclear Protein SM-22 (Transgelin) in the Rat Cystitis Model." The Journal of Urology, 173(4S), p. 22 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 173Issue 4SApril 2005Page: 22 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Thu-Suong Van Le More articles by this author Yukio Hayashi More articles by this author Shachi Tyagi More articles by this author Naoki Yoshimura More articles by this author Michael B. Chancellor More articles by this author Fernando de Miguel More articles by this author Expand All Advertisement PDF downloadLoading ...
Ecovisor: A Virtual Energy System for Carbon-Efficient Applications (2023)

Cloud platforms' rapid growth is raising significant concerns about their carbon emissions. To reduce carbon emissions, future cloud platforms will need to increase their reliance on renewable energy sources, such as solar and wind, which have zero emissions but are highly unreliable. Unfortunately, today's energy systems effectively mask this unreliability in hardware, which prevents applications from optimizing their carbon-efficiency, or work done per kilogram of carbon emitted. To address the problem, we design an "ecovisor", which virtualizes the energy system and exposes software-defined control of it to applications. An ecovisor enables each application to handle clean energy's unreliability in software based on its own specific requirements. We implement a small-scale ecovisor prototype that virtualizes a physical energy system to enable software-based application-level i) visibility into variable grid carbon-intensity and local renewable generation and ii) control of server power usage and battery charging and discharging. We evaluate the ecovisor approach by showing how multiple applications can concurrently exercise their virtual energy system in different ways to better optimize carbon-efficiency based on their specific requirements compared to general system-wide policies.
InGaN/GaN multiple quantum wells grown by metalorganic vapor phase epitaxy with mass transport (2000)

We report on studies of In0.12Ga0.88N/GaN heterostructures with three 35-Å-thick quantum wells (QWs) grown on sapphire substrates by metalorganic vapor phase epitaxy with employment of mass transport. The structure is demonstrated to show good structural and optical properties. The threading dislocation density is less than 107 cm−2 for the mass-transport regions. The photoluminescence (PL) spectrum is dominated by the rather narrow near-band gap emission at 2.97 eV with a linewidth of 40 meV. This emission has a typical PL decay time about 5 ns at 2 K within the PL contour. With increasing excitation intensity, an additional transition with longer decay time (about 200 ns) is enhanced at energy about 2.85 eV. The position of this line depends strongly on the excitation power. We explain the data in terms of a model, where the PL is a result of contribution from at least two nonequivalent QWs, which could be realized due to a potential gradient across the layers.
Control of SARS-CoV-2 infection by MT1-MMP-mediated shedding of ACE2 (2022)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic. Angiotensin-converting enzyme 2 (ACE2) is an entry receptor for SARS-CoV-2. The full-length membrane form of ACE2 (memACE2) undergoes ectodomain shedding to generate a shed soluble form (solACE2) that mediates SARS-CoV-2 entry via receptor-mediated endocytosis. Currently, it is not known how the physiological regulation of ACE2 shedding contributes to the etiology of COVID-19 in vivo. The present study identifies Membrane-type 1 Matrix Metalloproteinase (MT1-MMP) as a critical host protease for solACE2-mediated SARS-CoV-2 infection. SARS-CoV-2 infection leads to increased activation of MT1-MMP that is colocalized with ACE2 in human lung epithelium. Mechanistically, MT1-MMP directly cleaves memACE2 at M706-S to release solACE2<sub>18-706</sub> that binds to the SARS-CoV-2 spike proteins (S), thus facilitating cell entry of SARS-CoV-2. Human solACE2<sub>18-706</sub> enables SARS-CoV-2 infection in both non-permissive cells and naturally insusceptible C57BL/6 mice. Inhibition of MT1-MMP activities suppresses solACE2-directed entry of SARS-CoV-2 in human organoids and aged mice. Both solACE2 and circulating MT1-MMP are positively correlated in plasma of aged mice and humans. Our findings provide in vivo evidence demonstrating the contribution of ACE2 shedding to the etiology of COVID-19.
Reference by Name vs. Location in a Computer Filing System (1986)

The traditional name-based approach to storing and retrieving information in computers in now being supplemented on some systems by a spatial alternative – often driven by an office or desktop metaphor. These systems attempt to take advantage of the important role that location plays in retrieving objects in the real world (i.e. we must know where things are in order to retrieve them). This paper extends recent research by Jones and Dumais (1986) which used paper and pencil simulations to compare reference by name versus location. A computer filing system was developed in which folders could be stored and retrieved using combinations of location and name cues. Accuracy of location reference in a Location-only condition was initially comparable to that in a Name-only condition, but declined much more rapidly with increases in the number of objects. Adding location to name information did not improve retrieval accuracy, but was costly in terms of initial specification time. These results call into question the generality of spatial metaphors for information retrieval applications.
3D Printing of Liquid Metal Embedded Elastomers for Soft Thermal and Electrical Materials (2022)

Liquid metal embedded elastomers (LMEEs) are composed of a soft polymer matrix embedded with droplets of metal alloys that are liquid at room temperature. These soft matter composites exhibit exceptional combinations of elastic, electrical, and thermal properties that make them uniquely suited for applications in flexible electronics, soft robotics, and thermal management. However, the fabrication of LMEE structures has primarily relied on rudimentary techniques that limit patterning to simple planar geometries. Here, we introduce an approach for direct ink write (DIW) printing of a printable LMEE ink to create three-dimensional shapes with various designs. We use eutectic gallium-indium (EGaIn) as the liquid metal, which reacts with oxygen to form an electrically insulating oxide skin that acts as a surfactant and stabilizes the droplets for 3D printing. To rupture the oxide skin and achieve electrical conductivity, we encase the LMEE in a viscoelastic polymer and apply acoustic shock. For printed composites with a 80% LM volume fraction, this activation method allows for a volumetric electrical conductivity of 5 × 10<sup>4</sup> S cm<sup>-1</sup> (80% LM volume)─significantly higher than what had been previously reported with mechanically sintered EGaIn-silicone composites. Moreover, we demonstrate the ability to print 3D LMEE interfaces that provide enhanced charge transfer for a triboelectric nanogenerator (TENG) and improved thermal conductivity within a thermoelectric device (TED). The 3D printed LMEE can be integrated with a highly soft TED that is wearable and capable of providing cooling/heating to the skin through electrical stimulation.
4H-SiC DMOSFETs for High Speed Switching Applications (2005)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
N-Chlorotaurine Is an Effective Antiviral Agent against Adenovirus In Vitro and in the Ad5/NZW Rabbit Ocular Model (2006)

NCT demonstrated antiviral activity against adenovirus in vitro and in vivo. Further development of NCT as a topical antimicrobial is indicated.
Directly Patternable Low-k Materials for Flexible Displays with POSS as the Passivation Layer (2015)

The passivation layer, which is located between a pixel electrode and a data electrode, must provide sufficiently low parasitic capacitance and sufficient electrical insulation to reduce cross talk and signal distortion. The present demand for passivation materials for next-generation displays has created interest in substitutes with low dielectric constant, high transmittance, thermal stability, and patternability; these requirements cannot be met by the silicon nitride layer and silicon dioxide used currently. To meet these requirements, negative-tone patterning systems containing polyhedral oligomeric silsesquioxane (POSS) were developed by adopting two different approaches: use of POSS in the polymeric matrix and in the crosslinker. The polymeric matrix, poly(methacryl isobutyl POSS-r-hydroxy styrene), showed improved dielectric property and thermal stability. However, the POSS content was limited owing to poor solubility. A POSS crosslinker with epoxy functional groups was used along with phenol group containing polymeric matrices; poly(4-hydroxy styrene). It was possible to pattern the POSS crosslinker system by irradiating it with UV light and subjecting it to subsequent thermal treatment. With increasing POSS content, the crosslinked materials showed increased transparency, higher thermal stability, and lower dielectric constant. The system could also be patterned by irradiating it with UV through a patterned mask.