gebhart/patrepeval huggingface dataset:
Novel Diamidines with Activity against Babesia divergens In Vitro and Babesia microti In Vivo (2021)

ABSTRACT Dicationic diamidines, such as diminazene and pentamidine, are well-studied chemotherapeutic agents with significant activity against parasitic diseases. The in vitro activities of novel diamidine compounds against the Babesia divergens strains 1903B and 4201 were investigated. The most potent compound, a diphenyl furan, had a 50% inhibitory concentration (IC 50 ) of 1.5 ng/ml. In a murine model, several test compounds were effective enough to cure mice infected with Babesia microti at a dose of 12.5 and/or 25 mg/kg of body weight given by the subcutaneous route for 4 days. The best antibabesial properties were exhibited by terphenyls, benzimidazoles, diphenyl furans, pentamidine, and pentamidine analogues.
Biochemical disease‐free survival in patients with a high prostate‐specific antigen level (20–100 ng/mL) and clinically localized prostate cancer after radical prostatectomy (2003)

Patients with a high serum PSA level (20-100 ng/mL) may be appropriate candidates for RP. While the cancer-free survival is not as good as in patients with a lower PSA, a significant percentage of patients achieve BDFS. No preoperative variables were predictive of disease-free survival or time to PSA recurrence.
Cascade One‐Pot Synthesis of Orange‐Red‐Fluorescent Polycyclic Cinnolino[2,3‐f]phenanthridin‐9‐ium Salts by Palladium(II)‐Catalyzed C−H Bond Activation of 2‐Azobiaryl Compounds and Alkenes (2019)

Abstract Quaternary ammonium salts were synthesized in moderate to good yields through double oxidative C−H bond activation on azobenzenes. The mechanism of the highly regioselective reaction of 2‐azobiaryls with alkenes to give orange‐red‐fluorescent cinnolino[2,3‐ f ]phenanthridin‐9‐ium salts and 15 H ‐cinnolino[2,3‐ f ]phenanthridin‐9‐ium‐10‐ide is proposed to involve ortho C−H olefination of the 2‐azobiaryl compound with the alkene, intramolecular aza‐Michael addition, concerted metalation–deprotonation (CMD), reductive elimination, and oxidation.
Multi-Beam Interference Advances and Applications: Nano-Electronics, Photonic Crystals, Metamaterials, Subwavelength Structures, Optical Trapping, and Biomedical Structures (2011)

Research in recent years has greatly advanced the understanding and capabilities of multi-beam interference (MBI). With this technology it is now possible to generate a wide range of one-, two-, and three-dimensional periodic optical-intensity distributions at the micro- and nano-scale over a large length/area/volume. These patterns may be used directly or recorded in photo-sensitive materials using multi-beam interference lithography (MBIL) to accomplish subwavelength patterning. Advances in MBI and MBIL and a very wide range of applications areas including nano-electronics, photonic crystals, metamaterials, subwavelength structures, optical trapping, and biomedical structures are reviewed and put into a unified perspective.
[Late results following surgical repair of aneurysm of the descending thoracic aorta]. (1991)

A consecutive series of 74 patients was analyzed after repair of descending thoracic and thoracoabdominal aortic aneurysms. After hospital discharge there were 13/71 deaths (18%) during a mean follow-up of 60 +/- 20 months (range: 28-107). Actuarial analysis showed a mean survival rate of 89% after 1 year, 78% after 5 years and 71% after 9 years. During the same time period there were reoperations of the aorta in 10/71 patients (14%). Actuarial analysis showed freedom of reoperation in 97% after 1 year and in 80% after 5 years. Elective repair of these aneurysmal lesions can be recommended.
Ink Jet Printing of Microdot Arrays of Mesostructured Silica (2006)

We report a process for preparing microdot arrays of SiO 2 from a tetraethoxysilane precursor containing either a cationic (CTAB) or non‐ionic surfactant. Controlling the ink jet deposition parameters and precursor hydrolysis made it possible to obtain mesoporous silica with a Pm 3 n cubic structure, using CTAB, or an Fmmm orthorhombic structure, using a non‐ionic surfactant. The addition of hydrophobic organosilane F 3 C(CF 2 ) 5 CH 2 CH 2 Si(OC 2 H 5 ) 3 leads to the most regular and best‐defined three‐dimensional microdot array with a constant diameter of 155 μm and a regular space of 250 μm.
Defects and Textures (1998)

The prelims comprise: Definitions, Conventions and Methods Strong Deformations Resulting in Defects Topological Structure of Defects Geometrical Constraints and Textures References
Combined effects of CXCL8 (IL-8) and CXCR2 (IL-8R) gene polymorphisms on deregressed MACE EBV indexes of milk-related traits in Simmental bulls (2022)

CXCL8 (also known as IL-8) is a member of the CXC subfamily of chemokines that binds two of the seven transmembrane G-protein-coupled receptors (GPCRs), CXCR1 and CXCR2, to mediate and regulate leucocyte accumulation and activation at sites of inflammation. They are known to play a critical role in both disease susceptibility and infection outcome. The aim of this study was to investigate the entire sequences of <i>CXCL8</i> and <i>CXCR2</i> genes in thirty-one Simmental sires to evaluate the effects of genomic variants on the indexes of the bulls for milk, fat and protein yields, and for somatic cell score (SCS). Five new single nucleotide polymorphisms (SNPs) were found in <i>CXCR2</i> gene. The analysis of association indicated that one SNP in <i>CXCL8</i> and two in <i>CXCR2</i> influenced the considered traits. To evaluate the existence of functional haplotypic effects, combinations among the three genomic variants (SNP 1 in <i>CXCL8</i>, SNP 6 and SNP 7 in <i>CXCR2</i>) were investigated. Four different haplotypic alleles were identified in the experimental population, one of which at a high frequency (61%). Bulls with Hap 4 (G-C-G at SNP 1, SNP 6, and SNP 7 respectively) had more favourable indexes for SCS (<i>P</i> < 0.05). These results suggest that the SNPs in <i>CXCL8</i> and <i>CXCR2</i> may be potential genetic markers to improve udder health in the Simmental breed.
ChemInform Abstract: 1,2‐Migration of Perfluoroalkyl Groups in Anionotropic Rearrangement. The Acyloin Rearrangement of 4‐Perfluoroalkyl‐4‐quinols. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Fundamental Technologies in Modern Speech Recognition [From the Guest Editors] (2012)

The articles in this special issue brings together leading experts from various disciplines to explore the impact of new approaches to automatic speech recognition (ASR).
Inhibition of the Bloom's and Werner's Syndrome Helicases by G-Quadruplex Interacting Ligands (2001)

G-Quadruplex DNAs are folded, non-Watson-Crick structures that can form within guanine-rich DNA sequences such as telomeric repeats. Previous studies have identified a series of trisubstituted acridine derivatives that are potent and selective ligands for G-quadruplex DNA. These ligands have been shown previously to inhibit the activity of telomerase, the specialized reverse transcriptase that regulates telomere length. The RecQ family of DNA helicases, which includes the Bloom's (BLM) and Werner's (WRN) syndrome gene products, are apparently unique among cellular helicases in their ability to efficiently disrupt G-quadruplex DNA. This property may be relevant to telomere maintenance, since it is known that the sole budding yeast RecQ helicase, Sgs1p, is required for a telomerase-independent telomere lengthening pathway reminiscent of the "ALT" pathway in human cells. Here, we show that trisubstituted acridine ligands are potent inhibitors of the helicase activity of the BLM and WRN proteins on both G-quadruplex and B-form DNA substrates. Inhibition of helicase activity is associated with both a reduction in the level of binding of the helicase to G-quadruplex DNA and a reduction in the degree to which the G-quadruplex DNA can support DNA-dependent ATPase activity. We discuss these results in the context of the possible utility of trisubstituted acridines as antitumor agents for the disruption of both telomerase-dependent and telomerase-independent telomere maintenance.
Project NEPTUNE: an interactive, regional cabled ocean observatory in the Northeast Pacific (2003)

Next-generation studies of dynamic, interacting processes in the Earth-ocean-climate system require new interactive, in situ approaches to complement and fundamentally extend the more traditional ship-based expeditionary science that has dominated oceanographic research for more than 100 years. Key to these studies are regional cabled ocean observatories. A US/Canadian consortium is building NEPTUNE, a regional observatory in the northeast Pacific that will be spatially associated with the Juan de Fuca tectonic plate.
Specificity of Diastereomers of [99mTc]TRODAT-1 as Dopamine Transporter Imaging Agents (1998)

Recently, we reported the first human study of [99mTc]TRODAT-1, technetium, 2-[[2-[[[3-(4-chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]oct-2- yl]methyl](2-mercaptoethyl)amino]ethyl]amino]-ethanethiolato(3-)-o xo- [1R-(exo-exo)]-, as an imaging agent of central nervous system (CNS) dopamine transporters. Due to the existence of several chiral centers on this molecule, upon the formation of [99mTc]TRODAT-1 complex (2) several diastereomers could be created. Two major diastereomers of [99mTc]TRODAT-1 (2), designated as peak A (2A) and peak B (2B), were separated by HPLC. Biodistribution of the purified diastereomers 2A,B was evaluated in rats. It appears that 2A displayed a higher lipophilicity than 2B (PC = 305 and 229, respectively), and a similar trend was observed for the initial brain uptake at 2 min postinjection (0.50% and 0.28% dose/organ for 2A,B, respectively). At 60 min post-iv-injection, the specific uptakes, as measured by [striatum - cerebellum]/cerebellum ([ST-CB]/CB) ratio, were 1.72 and 2.79 for 2A,B, respectively. The higher [ST-CB]/CB ratio observed for 2B was corroborated by the results of an in vitro binding assay. Higher binding affinity for dopamine transporters was observed for 3B (Ki = 13.87 and 8.42 nM for the analogous rhenium complexes 3A,B, respectively). The structure of the [99mTc]TRODAT-1 complexes was deduced using nonradioactive rhenium as a surrogate for radioactive technetium complex. Reacting free TRODAT-1 ligand with [Bu4N][ReOCl4] yielded two major complexes: Re-TRODAT-1A (3A) and Re-TRODAT-1B (3B) (corresponding with peaks A and B of [99mTc]TRODAT-1, respectively), whose structures were determined by X-ray analysis. The X-ray structures show that both complexes have a pseudo-square-pyramidal structure of [RevO]3+N2S2 core with oxygen occupying the apical position and the N-alkyl substitution in syn-configuration to the oxo-rhenium bond. In conclusion, TRODAT-1 formed at least two diastereomers after complexing with a metal(V)-oxo (M = 99mTc, Re) center core. The two isomers display different binding affinities toward dopamine transporters and distinct properties of localization in the striatum area of the brain where the transporters are located.
Role of Transcriptional Corepressor CtBP1 in Prostate Cancer Progression (2012)

Transcriptional repressors and corepressors play a critical role in cellular homeostasis and are frequently altered in cancer. C-terminal binding protein 1 (CtBP1), a transcriptional corepressor that regulates the expression of tumor suppressors and genes involved in cell death, is known to play a role in multiple cancers. In this study, we observed the overexpression and mislocalization of CtBP1 in metastatic prostate cancer and demonstrated the functional significance of CtBP1 in prostate cancer progression. Transient and stable knockdown of CtBP1 in prostate cancer cells inhibited their proliferation and invasion. Expression profiling studies of prostate cancer cell lines revealed that multiple tumor suppressor genes are repressed by CtBP1. Furthermore, our studies indicate a role for CtBP1 in conferring radiation resistance to prostate cancer cell lines. In vivo studies using chicken chorioallantoic membrane assay, xenograft studies, and murine metastasis models suggested a role for CtBP1 in prostate tumor growth and metastasis. Taken together, our studies demonstrated that dysregulated expression of CtBP1 plays an important role in prostate cancer progression and may serve as a viable therapeutic target.
A Preliminary Approach to Select an Origami Source Pattern for Deployable Space Arrays (2022)

Abstract This paper presents a systematic approach for selecting an origami source pattern for deployable space array applications, followed by two case studies used to demonstrate the selection process. Applying origami principles to form engineering solutions can be a difficult task. Competing requirements may create confusion around which pattern is most favorable for the space array application. As a result, this paper aims to provide clarity on the process needed to effectively design an origami space array. The focus of this paper is to provide aerospace engineers and designers with a framework for identifying optimal origami source patterns for space array applications.
IoT-Enabled Water Distribution Systems—A Comparative Technological Review (2022)

Water distribution systems are one of the critical infrastructures and major assets of the water utility in a nation. The infrastructure of the distribution systems consists of resources, treatment plants, reservoirs, distribution lines, and consumers. A sustainable water distribution network management has to take care of accessibility, quality, quantity, and reliability of water. As water is becoming a depleting resource for the coming decades, the regulation and accounting of the water in terms of the above four parameters is a critical task. There have been many efforts towards the establishment of a monitoring and controlling framework, capable of automating various stages of the water distribution processes. The current trending technologies such as Information and Communication Technologies (ICT), Internet of Things (IoT), and Artificial Intelligence (AI) have the potential to track this spatially varying network to collect, process, and analyze the water distribution network attributes and events. In this work, we investigate the role and scope of the IoT technologies in different stages of the water distribution systems. Our survey covers the state-of-the-art monitoring and control systems for the water distribution networks, and the status of IoT architectures for water distribution networks. We explore the existing water distribution systems, providing the necessary background information on the current status. This work also presents an IoT Architecture for Intelligent Water Networks - IoTA4IWNet, for real-time monitoring and control of water distribution networks. We believe that to build a robust water distribution network, these components need to be designed and implemented effectively.
Metal‐Ion Batteries: Open‐Structured V2O5·nH2O Nanoflakes as Highly Reversible Cathode Material for Monovalent and Multivalent Intercalation Batteries (Adv. Energy Mater. 14/2017) (2017)

In article number 1602720, Ying Bai, Jun Lu, and co-workers develop a strategy of synthesizing V2O5·nH2O cathode with binder-free and nanoflake structure by a simple hydrothermal method. The water molecules in the oxide network are beneficial for ion mobility by electrostatic shielding effect, and suitable for monovalent (Li-ion, Na-ion) and multivalent (Al-ion) intercalation batteries.
Abnormal dependence of contact resistivity on hole concentration in nonalloyed ohmic contacts to p-GaN (2002)

The dependence of contact resistivity on hole concentration has been investigated for nonalloyed Pd contacts to p-GaN. The hole concentration was varied by changing the Mg concentration, [Mg], in p-GaN. The p-GaN having the [Mg] of 4.5×1019 cm−3 showed the hole concentration of 2.2×1017 cm−3, where contact resistivity was measured as 8.9×10−2 Ω cm2. When the [Mg] increased to 1.0×1020 cm−3, the hole concentration was significantly reduced to 2.0×1016 cm−3. Nevertheless, the Pd contacts on the p-GaN displayed contact resistivity as low as 5.5×10−4 Ω cm2. The abnormal dependence of contact resistivity on hole concentration may be explained by predominant current flow at the Pd/p-GaN interface through a deep level defect band, rather than the valence band.
APPLICATION OF THE GAMMA DISTRIBUTION MODEL TO MOLECULAR WEIGHT AND BOILING POINT DATA FOR PETROLEUM FRACTIONS (1990)

Abstract This paper applies the gamma distribution model for describing both the molar and boiling point distributions of heptanes-plus (C7+) fractions. The three-parameter distribution model has been fit to TBP (true boiling point) data from forty-four samples of stabilized petroleum liquid (stock tank oil and condensate), obtained from separation of reservoir fluids. An excellent fit was achieved for both molar and boiling point distributions, though molar distribution seems to be more accurately described by the distribution model. Two of the parameters, α and η, were correlated and fit to empirical equations for both molar and boiling point distributions. Since the third parameter, β, is defined in terms of α,η, and either average molecular weight or boiling point, it appears that a generalized correlation for molar and boiling point distributions may exist. We have not developed such correlations in this work, but our results provide the necessary groundwork for further research. KEYWORDS: Gamma distributionMolecular weightBoiling pointPetroleum fractions.
Garnet Random-Access Memory (1995)

Random-access memory (RAM) devices of proposed type exploit magneto-optical properties of magnetic garnets exhibiting perpendicular anisotropy. Magnetic writing and optical readout used. Provides nonvolatile storage and resists damage by ionizing radiation. Because of basic architecture and pinout requirements, most likely useful as small-capacity memory devices.
An Update on Thiol Signaling: S-Nitrosothiols, Hydrogen Sulfide and a Putative Role for Thionitrous Acid (2020)

Long considered vital to antioxidant defenses, thiol chemistry has more recently been recognized to be of fundamental importance to cell signaling. S-nitrosothiols-such as S-nitrosoglutathione (GSNO)-and hydrogen sulfide (H2S) are physiologic signaling thiols that are regulated enzymatically. Current evidence suggests that they modify target protein function primarily through post-translational modifications. GSNO is made by NOS and other metalloproteins; H2S by metabolism of cysteine, homocysteine and cystathionine precursors. GSNO generally acts independently of NO generation and has a variety of gene regulatory, immune modulator, vascular, respiratory and neuronal effects. Some of this physiology is shared with H2S, though the mechanisms differ. Recent evidence also suggests that molecules resulting from reactions between GSNO and H2S, such as thionitrous acid (HSNO), could also have a role in physiology. Taken together, these data suggest important new potential targets for thiol-based drug development.
Video Compressive Sensing Using Gaussian Mixture Models (2014)

A Gaussian mixture model (GMM)-based algorithm is proposed for video reconstruction from temporally compressed video measurements. The GMM is used to model spatio-temporal video patches, and the reconstruction can be efficiently computed based on analytic expressions. The GMM-based inversion method benefits from online adaptive learning and parallel computation. We demonstrate the efficacy of the proposed inversion method with videos reconstructed from simulated compressive video measurements, and from a real compressive video camera. We also use the GMM as a tool to investigate adaptive video compressive sensing, i.e., adaptive rate of temporal compression.
Observation of whispering-gallery modes in Si microdisks at room temperature (2007)

Whispering-gallery modes are observed at room temperature in silicon microdisk resonators fabricated on silicon-on-insulator substrates. Sharp luminescent peaks originating from the crystalline silicon film, corresponding to the whispering-gallery modes, are observed to change in microdisks with different diameters. Over 30 times enhancement of the photoluminescence from bulk silicon is observed due to the microdisk.
Maskless Preparation of Spatially‐Resolved Plasmonic Nanoparticles on Polydimethylsiloxane via In Situ Fluoride‐Assisted Synthesis (2021)

Abstract Here, a fluoride‐assisted route for the controlled in‐situ synthesis of metal nanoparticles (NPs) (i.e., AgNPs, AuNPs) on polydimethylsiloxane (PDMS) is reported. The size and coverage of the NPs on the PDMS surface are modulated with time and over space during the synthetic process, leveraging the improved yield (10×) and faster kinetics (100×) of NP formation in the presence of F − ions, compared to fluoride‐free approaches. This enables the maskless preparation of both linear and step gradients and patterns of NPs in 1D and 2D on the PDMS surface. As an application in flexible plasmonics/photonics, continuous and step‐wise spatial modulations of the plasmonic features of PDMS slabs with 1D and 2D AgNP gradients on the surface are demonstrated. An excellent spatially resolved tuning of key optical parameters, namely, optical density from zero to 5 and extinction ratio up to 100 dB, is achieved with AgNP gradients prepared in AgF solution for 12 minutes; the performance are comparable to those of commercial dielectric/interference filters. When used as a rejection filter in optical fluorescence microscopy, the AgNP‐PDMS slabs are able to reject the excitation laser at 405 nm and retain the green fluorescence of microbeads (100 µm) used as test cases.
Twentieth Symposium on Biotechnology for Fuels and Chemicals (1999)

active industrial participation in the organizing committee. Recently, the conference has begun a regular informal industrial roundtable (Session 4). This has become very popular as it allows industri
Optimal design of manufacturable three-dimensional composites with multifunctional characteristics (2003)

We present an optimization method to design three-dimensional composite microstructures with multifunctional characteristics. To illustrate the fascinating types of microstructures that can arise in multifunctional optimization, we apply our methodology to the study the simultaneous transport of heat and electricity in three-dimensional, two-phase composites. We assume that phase 1 has a high thermal conductivity but low electrical conductivity and phase 2 has a low thermal conductivity but high electrical conductivity. The objective functions consist of different combinations of the dimensionless effective thermal and electrical conductivities. When the sum of the effective thermal and electrical conductivities is maximized, we find that the optimal three-dimensional microstructures are triply periodic bicontinuous composites with interfaces that are the Schwartz primitive (P) and diamond (D) minimal surfaces. Maximizing the effective thermal conductivity and minimizing the effective electrical conductivity results in a special dispersion of inclusions in a connected matrix. The effective properties of both the bicontinuous and singly connected microstructures lie on known optimal cross-property bounds. When the sum of the effective thermal and electrical conductivities is minimized, the result is the three-dimensional checkerboard, which is the optimal single-scale microstructure. It is important to note that current fabrication techniques enable one to manufacture all of the aforementioned optimal single-scale composites.