gebhart/patrepeval huggingface dataset:
Technical aspects of catheter-related interventions in the liver of the rabbit (1997)

The 0.66-mm system has proved to be advantageous over the 1.0-mm catheterization in avoiding arterial spasm. Direct portography as well as catheterization of the hepatic vein from a jugular approach are hazardous, leading to serious complications including the death of the animal.
Abstract 93: The Radiation Mitigator MMS350 Prevents Bradyarrhythmias in Irradiated Mice (2017)

Introduction: Radiation exposure is a health hazard and the potential exposure from healthcare and other anthropogenic sources necessitates radioprotective therapy. MMS350, a water soluble oxetanyl sulfoxide, is a radiation mitigator which has protective effects on pulmonary and bone marrow cells following irradiation. We have previously shown that radiation exposure causes cardiac conduction damage including bradyarrhythmia and atrioventricular (AV) block in mice. This study investigates whether MMS350 protects against cardiac conduction damage in C57Bl/6 mice following radiation exposure. Methods: Mice were treated with MMS350 (400 μM) in drinking water ad libitum for 14 days prior to and for 30 days following irradiation, and were injected with MMS350 (20 mg/kg IV) 30 minutes prior to irradiation. Control (n=12) and MMS350-dosed (n=8) mice were total body irradiated (TBI) using a Pantak HF-320 Orthovoltage X-ray machine for a total dose of 6 Gy (1.38 Gy/min). Four-lead ECGs were performed on anesthetized mice at baseline and at day 30; PR, QRS, and QTc (QT normalized to heart rate) intervals were analyzed. Results: TBI control mice had PR (51.2 ± 5.8 vs. 43.4 ± 2.6 ms, P=0.003) and QRS (13.7 ± 0.2 vs. 13.0 ± 0.6 ms, P=0.02) interval prolongation at 30 days compared to baseline, while QTc trended towards a significant lengthening (88.4 ± 6.8 vs. 80.1 ± 10.4 ms, P=0.06). TBI MMS350 mice had no significant PR (46.2 ± 7.8 vs. 42.9 ± 5.1 ms, P=0.41) or QRS (14.0 ± 2.4 vs. 13.7 ± 0.8 ms, P=0.71) interval prolongation at 30 days compared to baseline, while QTc trended towards a significant lengthening (86.1 ± 7.9 vs. 73.0 ± 15.2 ms, P=0.05). New prolonged pauses and/or AV block occurred by day 30 post-irradiation in a third of TBI control mice but not in TBI MMS350 mice. Additionally, compared to baseline, day 6 post- irradiation TBI-only mice lost weight (males: 25.0 ± 1.8 to 24.2 ± 1.6g, P=0.004; females: 21.2 ± 1.0 to 19.2 ± 1.3g, P=0.01) while MMS350-dosed mice did not (males: 25.4 ± 1.7 to 27.8 ± 0.5g, P=0.12); females: 19.3 ± 0.2 to 21.0 ± 1.2g, P=0.08). Conclusion: Our results suggest that MMS350 protects irradiated mice from bradyarrhythmias, cardiac conduction damage, and radiation-associated weight loss. These findings lend further support to MMS350 as a radiation mitigator.
Charakterisierung von CVD-diamantbeschichteten Titanbasislegierungen für biomedizinische Anwendungen (2009)

Article Charakterisierung von CVD-diamantbeschichteten Titanbasislegierungen für biomedizinische Anwendungen was published on January 1, 1998 in the journal Biomedical Engineering / Biomedizinische Technik (volume 43, issue s1).
Targeting Plk1 with siRNNs in primary cells from pediatric B-cell acute lymphoblastic leukemia patients (2020)

B-cell acute lymphoblastic leukemia (B-ALL) accounts for nearly one fifth of all childhood cancers and current challenges in B-ALL treatment include resistance, relapse and late-onset side effects due to the chemotherapy. To overcome these hurdles, novel therapies need to be investigated. One promising target is Polo-like kinase 1 (Plk1), a key regulator of the cell cycle. In this study, the Plk family expression is investigated in primary peripheral blood and bone marrow mononuclear cells from ten pediatric B-ALL patients. For the first time, short interfering RiboNucleic Neutrals (siRNNs) that enter cells without a transfection reagent are used to target Plk1 mRNA in primary cells from pediatric B-ALL patients. Our results show that the expression of Plk1 and Plk4 is significantly higher in pediatric B-ALL patients compared to healthy donors. Moreover, treatment of primary peripheral blood and bone marrow mononuclear cells from pediatric B-ALL patients, cultured ex vivo, with Plk1-targeting siRNNs results in cleavage of Plk1 mRNA. Importantly, the Plk1 knockdown is specific and does not affect other Plk members in contrast to many small molecule Plk1 inhibitors. Thus, Plk1 is a potential therapeutic target in pediatric B-ALL and selective targeting of Plk1 can be achieved by the use of siRNNs.
A site analysis of purple loosestrife (Lythrum salicaria) invasion in northern Michigan. (2000)

Incubation of rat thymocytes with the inhibitors of protein phosphatase such as calyculin A and okadaic acid resulted in an increase in DNA fragmentation. These effects were dependent on the concentration of the inhibitors and the incubation time. Analyses of the fragmented DNA revealed the production of approximately 50 kbp of DNA and a 180 bp DNA ladder. In addition, a laser scanning-microscopic analysis showed that these compounds caused nuclear condensation. Thus, these results demonstrated that protein phosphatase inhibitors induced thymocyte apoptosis. The inhibitors of protein phosphatase increased the phosphorylation of proteins of approximately 15 kDa. The phosphorylation of proteins preceded the DNA fragmentation induced by these inhibitors. Judging from acetic acid-urea-Triton X-100 gel electrophoresis, the phosphorylated proteins were histone H1 and H2A/H3. Therefore, these results suggest that phosphorylation of histones triggers the DNA fragmentation of thymocytes undergoing apoptosis.
Green, Scalable, Binderless Fabrication of a Single-Walled Carbon Nanotube Nonwoven Fabric Based on an Ancient Japanese Paper Process (2013)

We propose a fabrication method for carbon nanotube (CNT) nonwoven fabrics based on an ancient Japanese papermaking process where paper is made from natural plant fibers. In our method, CNT nonwoven fabrics are made by a scalable process of filtering binder-free, aqueous suspensions of CNTs. The aqueous suspension of these entangled single-walled carbon nanotube (SWNT) aggregates enabled smooth filtration through a cellulose filter with large pores (8 μm). The "wet SWNT cakes," which were composed solely of SWNT and water and obtained after filtration, were press-dried to fabricate an SWNT nonwoven fabric. This environmentally friendly process employs water and the raw CNT material alone. Moreover, the scalability of this process was demonstrated by manufacturing a large area (A3, 30 × 42 cm; thickness: 40-150 μm), self-supporting SWNT nonwoven fabric with a density of 0.4 g/cm(3), a basis weight of 0.2 g/m(2) , a porosity of 63%, and a specific surface area of 740 m(2)/g. This SWNT nonwoven fabric is anticipated to find application as functional particle-supported sheets, electrode materials, and filters.
Two-Step Plasma-Texturing Process for Multicrystalline Silicon Solar Cells With Linear Microwave Plasma Sources (2012)

Surface texturing of crystalline silicon solar cells allows reduction of the reflection of sunlight and enhances photon generation. Plasma-based texturing offers significant advantages over the conventional wet approach, i.e., reduced Si consumption, thin wafer compatibility, increased throughput, and reduced chemical waste. However, it still suffers from insufficient electric yield, i.e., bad performance of plasma-processed solar cells. This paper describes advances made in plasma texturing by means of a linear microwave plasma source. The advantage of a two-step plasma-texturing process is demonstrated, leading to a smoother surface roughness, and resulting in an increased open-circuit voltage, together with a reduced processing time. In addition, the described technology allows a significant reduction of surface damage and could be implemented on a production line for crystalline silicon solar cell manufacturing.
A Pedagogical Framework for Manufacturing Process Design (2018)

In recent years, federal economists have argued that manufacturing is a vital part of the U.S. economy, providing a disproportionate share of engineering jobs, research and patents. At the center of these arguments is an understanding that manufacturing research and development is important to the innovation and competitiveness of manufacturing firms. As a result, federal agencies have made significant investments in public-private partnerships stimulating industry-directed research and development on university campuses. At the same time, state and federal agencies have increasingly encouraged the commercialization of university research for regional economic development. Combined, these investments have increased the amount of manufacturing engineering activity at U.S. universities providing opportunities to advance manufacturing engineering practice. This paper discusses efforts at Oregon State University to teach manufacturing process design based on twenty years of findings from efforts to translate microchannel process technology into the marketplace.
Anti-inflammatory Activity of the Phenolic-rich Extract of Schotia brachypetalea Sond. Fam. Fabaceae, Cultivated in Egypt (2015)

Aim: The current study evaluates the anti - inflammatory activity of the methanolic leaf extract of Schotia brachypetalea , isolates and identifies the phenolic content and standardizes the crude leaf extract using HPLC. Place and Duration of study: This study was conducted in the D epartments of Pharmacognosy and Pharmacology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt during the period between July 2013 and December 2014. Methodology: The anti - inflammatory activity was assessed using 2 models viz. carrageenan induced rat paw edema and croton oil induced ear edema. Column and paper chromatography Original Research Article
Chitosan as a water-based photoresist for DUV lithography (2023)

DUV photolithography, as the major process of nanofabrication, typically requires high volumes of toxic chemicals within resist formulation, solvent and developer. In this context, alternative chemistries to current petroleum-derived photoresists are proposed to reduce environmental impacts. Chitosan represents a bio-sourced resist allowing water-based patterning processes free of organic solvent and alkali-based developers, by substitution with a green solvent (deionized (DI) water). This paper present last stepwise process in the patterning integration with a chitosan-based resist. Preliminary results using a 300 mm pilot line scale at CEA-Leti demonstrate patterns resolution down to 800 nm along with plasma etch transfer into Si substrate. Finally, the environmental impact through life cycle analysis (LCA) of the whole process based on chitosan resist is assessed and compared to conventional solvent-based processes.
Targeting Histone Deacetylase 6 and the Aggresome Pathway in Acute Lymphoblastic Leukemia Cells. (2007)

Abstract Acute lymphoblastic leukemia (ALL) is the most common form of childhood cancer. Despite effective chemotherapy, 20% of patients will relapse. Therefore, it is critical that we identify novel therapies to treat ALL. We are studying a new small molecule compound known as tubacin (tubulin acetylation inducer) that selectively inhibits histone deacetylase 6 (HDAC6). HDAC6 binds to polyubiquitinated misfolded proteins and to dynein motor proteins, including alpha-tubulin, thereby recruiting misfolded or unwanted proteins to aggresomes and subsequent degradation by the lysosome. Tubacin was discovered through a chemical genetic screen of a 7,392 small molecule library and was found to induce acetylation of alpha-tubulin by inhibiting one of the two catalytic domains of HDAC6. This inhibition disrupts the interaction of HDAC6 with dynein resulting in marked accumulation of ubiquitinated proteins. Previous work demonstrated that treatment of multiple myeloma cells with tubacin inhibited growth at low micromolar concentrations. Tubacin does not appear to affect global histone acetylation, gene expression, or cell cycle regulation. To determine the effects of tubacin in human ALL cells, we treated both B- and T-cell ALL cell lines with varying concentrations of the drug and performed MTT assays. In T-ALL cells (Jurkat, Loucy), the IC50 of tubacin was found to be 1 to 3 uM, while in B-cell ALL cells (REH, Nalm-6), the IC50 was 2 to 5uM. Tubacin induced apoptosis of Jurkat and Loucy cells stained with Annexin V and propidium iodide. Within 12 hours, we observed increased protein polyubiquitination and PARP cleavage, but no difference in Rb phosphorylation in cells treated with tubacin. Furthermore, tubacin treatment increased acetylation of alpha-tubulin in Loucy and Jurkat cells within 3 hours. To study whether tubacin was toxic to normal hematopoietic cells, we treated human bone marrow cells cultured in methylcellulose containing IL-3, IL-6, and Stem Cell Factor with varying concentrations of tubacin. The IC50 of 20uM was determined from numbers of colonies plated in triplicate. Similarly, treatment of normal human lymphocytes cultured in IL-2, demonstrated an IC50 of 16uM. Finally, we examined the effects of tubacin on growth of primary ALL cells. Bone marrow cells from three patients with B-cell ALL at diagnosis were cultured in tubacin at varying concentrations and MTT assays were performed. In two of the three ALL samples, the IC50 was less than 5uM. Experiments to study the effects of tubacin in mouse models of leukemia are in progress. Our results suggest that inhibition of HDAC6 and the aggresome pathway provides a novel approach to treat ALL.
Sensorics for Detergency (2005)

This chapter contains sections titled: Introduction Household Laundry Products Conventional Powder Heavy-Duty Detergents Compact and Supercompact Heavy-Duty Detergents Extruded Heavy Duty Detergents Heavy-duty Detergent Tablets Color Heavy-Duty Detergents Liquid Heavy-duty Detergents Specialty Detergents Detergent Compositions Surfactants Builders Bleaches Auxiliary Ingredients Enzymes Soil Antiredeposition Agents, Soil Repellent/Soil Release Agents Foam Regulators Corrosion Inhibitors Fluorescent Whitening Agents Fragrances Dyes Fillers Physical Parameters in Detergency Introduction Surface Tension and Wetting Adsorption at the Solid/Liquid Interface Liquid/Liquid Interface Phase Behavior of Surfactant Systems Foaming On-line Sensorics in Detergent Development Product Relevant Physico-chemical Parameters and their Availability for On-line Determination On-line Determination of Dynamic Surface Tension by the Bubble-pressure Method Other Accessible On-line Parameters Sensors in Household Appliances Introduction Sensor Applications Turbidity Conductivity Water Hardness Concentration Miscellaneous Conclusion Detergent Products with Built in Sensor Functions Introduction: “Intelligent” Detergent Products Automatic Dishwashing Detergent (ADD) Tablets Laundry Detergent Tablets References
PainPoints: A Framework for Language-based Detection of Chronic Pain and Expert-Collaborative Text-Summarization (2022)

Chronic pain is a pervasive disorder which is often very disabling and is associated with comorbidities such as depression and anxiety. Neuropathic Pain (NP) is a common sub-type which is often caused due to nerve damage and has a known pathophysiology. Another common sub-type is Fibromyalgia (FM) which is described as musculoskeletal, diffuse pain that is widespread through the body. The pathophysiology of FM is poorly understood, making it very hard to diagnose. Standard medications and treatments for FM and NP differ from one another and if misdiagnosed it can cause an increase in symptom severity. To overcome this difficulty, we propose a novel framework, PainPoints, which accurately detects the sub-type of pain and generates clinical notes via summarizing the patient interviews. Specifically, PainPoints makes use of large language models to perform sentence-level classification of the text obtained from interviews of FM and NP patients with a reliable AUC of 0.83. Using a sufficiency-based interpretability approach, we explain how the fine-tuned model accurately picks up on the nuances that patients use to describe their pain. Finally, we generate summaries of these interviews via expert interventions by introducing a novel facet-based approach. PainPoints thus enables practitioners to add/drop facets and generate a custom summary based on the notion of "facet-coverage" which is also introduced in this work.
Structural and functional characterization of SplA, an exclusively specific protease of Staphylococcus aureus (2009)

Staphylococcus aureus is a dangerous human pathogen whose antibiotic resistance is steadily increasing and no efficient vaccine is as yet available. This serious threat drives extensive studies on staphylococcal physiology and pathogenicity pathways, especially virulence factors. Spl (serine protease-like) proteins encoded by an operon containing up to six genes are a good example of poorly characterized secreted proteins probably involved in virulence. In the present study, we describe an efficient heterologous expression system for SplA and detailed biochemical and structural characterization of the recombinant SplA protease. The enzyme shares a significant sequence homology to V8 protease and epidermolytic toxins which are well documented staphylococcal virulence factors. SplA has a very narrow substrate specificity apparently imposed by the precise recognition of three amino acid residues positioned N-terminal to the hydrolysed peptide bond. To explain determinants of this extended specificity we resolve the crystal structure of SplA and define the consensus model of substrate binding. Furthermore we demonstrate that artificial N-terminal elongation of mature SplA mimicking a naturally present signal peptide abolishes enzymatic activity. The probable physiological role of the process is discussed. Of interest, even though precise N-terminal trimming is a common regulatory mechanism among S1 family enzymes, the crystal structure of SplA reveals novel significantly different mechanistic details.
Electron and hole mobility in tris(8-hydroxyquinolinolato-N1,O8) aluminum (1995)

We have measured the drift mobility of electrons and holes in thin, vapor-deposited films of tris(8-hydroxyquinolinolato-N1,O8) aluminum using a time of flight photoconductivity technique. The drift of mobility of both carriers is dispersive and strongly electric field and temperature dependent. At ambient temperature and an electric field of 4×105 V cm−1, the effective mobility of electrons and holes is 1.4×10−6 and 2×10−8 cm2 V−1 s−1, respectively, in a 400 nm thick sample.
A Single Case Feasibility Study of Sensorimotor Rhythm Neurofeedback in Parkinson’s Disease (2021)

Electroencephalographic activity over the sensorimotor cortex has been one of the best studied targets for neurofeedback therapy. Parkinson's disease patients display abnormal brain rhythms in the motor cortex caused by increased synchrony in the basal ganglia-cortical pathway. Few studies have examined the effects of sensorimotor-based neurofeedback therapy in humans with PD. In this pilot study, one patient, diagnosed with Parkinson's disease 10 years prior, participated in two consecutive days of EEG neurofeedback training to increase sensorimotor rhythm (SMR) power over the motor cortex. Using a visual display connected to ongoing EEG, the patient voluntarily manipulated SMR power, and he/she was awarded with points to positively reinforce successful increases over a predefined threshold. Recorded EEG data were source localized and analyzed for the occurrence of high amplitude bursts of SMR activity as well as bursts in the beta frequency band in the precentral cortex. The rate of SMR bursts increased with each subsequent training session, while the rate of beta bursts only increased on the final session. Relative power in the beta band, a marker of PD symptom severity, decreased over the motor cortex in the later session. These results provide first evidence for the feasibility of SMR neurofeedback training as a non-invasive therapy for reducing Parkinson's disease related activity and upregulating SMR in the human motor cortex.
Physiological variation in vascular reactivity of breast tissue over the menstrual cycle demonstrated by optical tomography (2004)

Using optical tomography we demonstrate that breast physiology changes over the 28 day menstrual cycle. This can be demonstrated by the vasculature’s compliance and degree of heterogeneity in response to simple manipulations (e.g., Valsalva maneuver).
Dynamic QoS Negotiation for Next-Generation Wireless Communications Systems (2007)

Users in next generation wireless networks are expected to be highly dynamic while maintaining connectivity through different devices with different processing and communication capabilities. In wireless environments, bandwidth is scarce and channel conditions are time-varying. To guarantee quality of service (QoS) to users roaming between heterogeneous wireless networks, a dynamic QoS negotiation mechanism, which allows users to dynamically negotiate their service-levels with the network, is required. Several protocols for dynamic service level negotiation have been proposed, each focusing on a particular mode. This paper presents an overview of these protocols and discusses their limitations. To alleviate these shortcomings, a dynamic QoS negotiation scheme to allow users to change their service levels in response to changes in both network conditions and their own resource requirements is proposed. In the proposed scheme, upon an intra-domain handoff of a mobile node, the visited access point consults the previously used access point to confirm the legitimacy of the service negotiation request issued by the mobile node. The performance of the proposed scheme has been investigated and compared with other dynamic negotiation approaches. It was demonstrated that the proposed scheme outperforms the state-of-the-art method, in terms of the signaling overhead and data storage, at the expense of a slight increase in the overall negotiation delay.
Faculty Opinions recommendation of Reversible site-specific tagging of enzymatically synthesized RNAs using aldehyde-hydrazine chemistry and protease-cleavable linkers. (2007)

Read the full review for this Faculty Opinions recommended article: Reversible site-specific tagging of enzymatically synthesized RNAs using aldehyde-hydrazine chemistry and protease-cleavable linkers.