gebhart/patrepeval huggingface dataset:
Cost Affordable Developments in Titanium Technology and Applications (2010)

Titanium is the “wonder” metal, which makes sense as the material of choice for a wide variety of applications. However, because of its relatively high price- a result of extraction and processing costs- it is used basically only when it is the only choice; with the caveat that titanium has a bright “image” which can lead to use even when the economics are unfavorable. The major thrust in the area of titanium technology has been aimed at achieving cost reduction rather than developing alloys with enhanced properties. This paper will overview the potential areas which are amenable to cost reduction and present some applications of titanium and it’s alloys.
Therapeutic Advantage in Selective Ligament Augmentation for Partial Tears of the Anterior Cruciate Ligament (2013)

Selected ACL augmentation could be a good choice for the repair of partial ACL injury by preserving the uninjured portion of the ACL, which in turn could maintain the anatomic position of the ligament and its biomechanical function.
Zinc-Doped Copper Oxide Nanocomposites Inhibit the Growth of Pancreatic Cancer by Inducing Autophagy Through AMPK/mTOR Pathway (2019)

Zinc doped copper oxide nanocomposites (Zn-CuO NPs) is a novel doped metal nanomaterial synthesized by our group using the sonochemical method. Our previous studies have shown that Zn-CuO NPs could inhibit cancer cell proliferation by inducing apoptosis via ROS-mediated pathway. In the present study, we studied the anticancer effect of Zn-CuO NPs on human pancreatic cancer cells. MTS assay revealed that Zn-CuO NPs was able to inhibit cancer cell growth. TEM, flow cytometry and fluorescence microscope analysis showed that Zn-CuO NPs induced autophagy significantly; the number of autophagosomes increased obviously in cells treated with Zn-CuO NPs. Western blot analysis revealed that treatment with the NPs resulted in activation of AMPK/mTOR pathway in both AsPC-1 and MIA Paca-2 cells in dose dependent manners. Moreover, in the presence of AMPK activator AMPKinone, the protein level of p-AMPK, p-ULK1, Beclin-1 and LC3-II/LC3-I increased, while the protein expression of p-AMPK, p-ULK1, Beclin-1 and LC3-II/LC3-I decreased in the presence of AMPK inhibitor Compound C. <i>In vivo</i> study using xenograft mice revealed that Zn-CuO NPs significantly inhibited tumor growth with low toxicity. Our study confirms that Zn-CuO NPs inhibit the tumor growth both <i>in vitro</i> and <i>in vivo</i> for pancreatic cancer. AMPK/mTOR pathway plays an important role in the NPs induced inhibition of tumor growth.
eNANOS: Coordinated Scheduling in Grid Environments. (2005)

Permission to make digital or hard copies of portions of this work for personal or classroom use is granted provided that the copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. To copy otherwise requires prior specific permission by the publisher mentioned above.
Automated Analysis of Multiparametric Magnetic Resonance Imaging/Magnetic Resonance Elastography Exams for Prediction of Nonalcoholic Steatohepatitis (2021)

2 TECHNICAL EFFICACY STAGE: 2.
P2-318 Long-term (5–10 yrs) results of balloon mitral commissurotomy for rheumatic mitral stenosis (2011)

Introduction Percutaneous mitral commissurotomy (PTMC) has been known as an effective therapeutic modality for moderate to severe mitral stenosis. However, long-term results and factors influencing late outcome after PTMC remain to be elucidated. Methods Retrospective study of symptomatic severe MS patients who underwent PTMC from 1994 to 1999 in our cardiology unit to evaluate the immediate and long term echocardiographic results of PTMC in 158 patients was conducted. We did transthoracic and transoesophageal echocardio- graphic study of all symptomatic severe mitral stenosis patients. Those patients who underwent PTMC were selected for the study. Results Males constituted 31% and Females were 68% of total patient population. The mean age of patients was 31.09±9.7 years. Peak mitral valve gradients increased from 8.9 mm Hg±4.3 at day one to 14.6 mm Hg±9.8 and 18.5±8.2 at 5 years and 10 years respectively. Mean MVG was 4.7±2.4 mm Hg on day one and 9.18±5.62 and 11.8±6.66 at 5 and 10 years respectively. All patients in AF were above 40Yrs. Successful PTMC was done in 94.89%. Acute complications were anterior leaflet tear, cardiac tamponade. Mortality immediately after PTMC (1- during MVR), at 10 yrs (3 - one case secondary to severe MR, one patient stroke related, one patient no cardiac cause). Emergency MVR was done in two patients. Failed PTMC was present in five cases; CMV was done in those cases. Conclusion Restenosis after 10-year follow-up after successful PTMC, was influenced more by Pre PTMC LA size, mitral valve area, subvalvular fusion than on immediate post PTMC parameters.
Photofragment Alignment and Orientation (1982)

Machine learning (ML) is transforming all areas of science. The complex and time-consuming calculations in molecular simulations are particularly suitable for an ML revolution and have already been profoundly affected by the application of existing ML ...Read More
Effects of Surotomycin on Clostridium difficile Viability and Toxin Production In Vitro (2015)

ABSTRACT The increasing incidence and severity of infection by Clostridium difficile have stimulated attempts to develop new antimicrobial therapies. We report here the relative abilities of two antibiotics (metronidazole and vancomycin) in current use for treating C. difficile infection and of a third antimicrobial, surotomycin, to kill C. difficile cells at various stages of development and to inhibit the production of the toxin proteins that are the major virulence factors. The results indicate that none of the drugs affects the viability of spores at 8× MIC or 80× MIC and that all of the drugs kill exponential-phase cells when provided at 8× MIC. In contrast, none of the drugs killed stationary-phase cells or inhibited toxin production when provided at 8× MIC and neither vancomycin nor metronidazole killed stationary-phase cells when provided at 80× MIC. Surotomycin, on the other hand, did kill stationary-phase cells when provided at 80× MIC but did so without inducing lysis.
4-(2-Bromophenyl)-2-phenylpyrano[3,2-c]chromen-5(4H)-one (2012)

In the title compound, C24H15BrO3, the pyran-ochromenone ring is essentially planar, while the 2-bromo-phenyl group is almost perpendicular to it [85.58 (6)°]. In the crystal, inversion dimers linked by pairs of weak C-H⋯π bonds occur; there is also a short inter-atomic contact found between the Br and carbonyl O atoms [3.016 (1) Å].
PowerBookmarks (1999)

article PowerBookmarks: a system for personalizable Web information organization, sharing, and management Share on Authors: Wen-Syan Li C&C Research Laboratories, NEC USA, Inc., 110 Rio Robles, M/S SJ1OO, San Jose, CA C&C Research Laboratories, NEC USA, Inc., 110 Rio Robles, M/S SJ1OO, San Jose, CAView Profile , Quoc Vu C&C Research Laboratories, NEC USA, Inc., 110 Rio Robles, M/S SJ1OO, San Jose, CA C&C Research Laboratories, NEC USA, Inc., 110 Rio Robles, M/S SJ1OO, San Jose, CAView Profile , Edward Chang C&C Research Laboratories, NEC USA, Inc., 110 Rio Robles, M/S SJ1OO, San Jose, CA C&C Research Laboratories, NEC USA, Inc., 110 Rio Robles, M/S SJ1OO, San Jose, CAView Profile , Divyakant Agrawal View Profile , Kyoji Hirata View Profile , Sougata Mukherjea View Profile , Yi-Leh Wu View Profile , Corey Bufi View Profile , Chen-Chuan Kevin Chang View Profile , Yoshinori Hara C&C Research Laboratories, NEC USA, Inc., 110 Rio Robles, M/S SJ1OO, San Jose, CA C&C Research Laboratories, NEC USA, Inc., 110 Rio Robles, M/S SJ1OO, San Jose, CAView Profile , Reiko Ito 5th Development Department, 2nd Computers Software Division, NEC Corporation, 1-10, Nisshin-Cho, Fuchu-Shi, Tokyo 183-8501, Japan 5th Development Department, 2nd Computers Software Division, NEC Corporation, 1-10, Nisshin-Cho, Fuchu-Shi, Tokyo 183-8501, JapanView Profile , Yutaka Kimura 5th Development Department, 2nd Computers Software Division, NEC Corporation, 1-10, Nisshin-Cho, Fuchu-Shi, Tokyo 183-8501, Japan 5th Development Department, 2nd Computers Software Division, NEC Corporation, 1-10, Nisshin-Cho, Fuchu-Shi, Tokyo 183-8501, JapanView Profile , Kezuyuki Shimazu 5th Development Department, 2nd Computers Software Division, NEC Corporation, 1-10, Nisshin-Cho, Fuchu-Shi, Tokyo 183-8501, Japan 5th Development Department, 2nd Computers Software Division, NEC Corporation, 1-10, Nisshin-Cho, Fuchu-Shi, Tokyo 183-8501, JapanView Profile , Yukiyoshi Saito 5th Development Department, 2nd Computers Software Division, NEC Corporation, 1-10, Nisshin-Cho, Fuchu-Shi, Tokyo 183-8501, Japan 5th Development Department, 2nd Computers Software Division, NEC Corporation, 1-10, Nisshin-Cho, Fuchu-Shi, Tokyo 183-8501, JapanView Profile Authors Info & Claims ACM SIGMOD RecordVolume 28Issue 2June 1999 pp 565–567https://doi.org/10.1145/304181.304578Published:01 June 1999 22citation475DownloadsMetricsTotal Citations22Total Downloads475Last 12 Months2Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
SARS-CoV-2 Infection Severity Is Linked to Superior Humoral Immunity against the Spike (2021)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently causing a global pandemic. The antigen specificity of the antibody response mounted against this novel virus is not understood in detail. Here, we report that subjects with a more severe SARS-CoV-2 infection exhibit a larger antibody response against the spike and nucleocapsid protein and epitope spreading to subdominant viral antigens, such as open reading frame 8 and nonstructural proteins. Subjects with a greater antibody response mounted a larger memory B cell response against the spike, but not the nucleocapsid protein. Additionally, we revealed that antibodies against the spike are still capable of binding the D614G spike mutant and cross-react with the SARS-CoV-1 receptor binding domain. Together, this study reveals that subjects with a more severe SARS-CoV-2 infection exhibit a greater overall antibody response to the spike and nucleocapsid protein and a larger memory B cell response against the spike.<b>IMPORTANCE</b> With the ongoing pandemic, it is critical to understand how natural immunity against SARS-CoV-2 and COVID-19 develops. We have identified that subjects with more severe COVID-19 disease mount a more robust and neutralizing antibody response against SARS-CoV-2 spike protein. Subjects who mounted a larger response against the spike also mounted antibody responses against other viral antigens, including the nucleocapsid protein and ORF8. Additionally, this study reveals that subjects with more severe disease mount a larger memory B cell response against the spike. These data suggest that subjects with more severe COVID-19 disease are likely better protected from reinfection with SARS-CoV-2.
Adult polycystic kidney disease and linked RFLPs at the alpha globin locus: a genetic study in the South Wales population. (1987)

Thirteen South Wales kindreds with adult polycystic kidney disease have been studied for genetic linkage using the alpha globin and 3'HVR probes. A maximum lod score of 24.187 was found at a recombination fraction of 0.03. This study supports the existence of a single locus on chromosome 16 responsible for the disorder.
Familial Clonal Hematopoiesis in a Long Telomere Syndrome (2023)

<i>POT1</i> mutations associated with long telomere length conferred a predisposition to a familial clonal hematopoiesis syndrome that was associated with a range of benign and malignant solid neoplasms. The risk of these phenotypes was mediated by extended cellular longevity and by the capacity to maintain telomeres over time. (Funded by the National Institutes of Health and others.).
Inverse occlusion, a binocularly motivated treatment for amblyopia (2018)

Abstract Recent laboratory finding suggest that short-term patching the amblyopic eye (i.e., inverse occlusion) results in a larger and more sustained improvement in the binocular balance compared with normal controls. In this study, we investigate the cumulative effects of the short-term inverse occlusion in adults and old children with amblyopia. A prospective cohort study of 18 amblyopes (10-35 years old; 3 with strabismus) who have been subjected to 2 hours/day of inverse occlusion for 2 months. Patients who required refractive correction or whose refractive correction needed updating were given a 2-month period of refractive adaptation. The primary outcome measure was the binocular balance which was measured using a phase combination task, the secondary outcome measures were the best corrected visual acuity which was measured with a Tumbling E acuity chart and convert to logMAR units and the stereo acuity which was measured with the Random-dot preschool stereotest. The averaged binocular gain was 0.11 in terms of the effective contrast ratio (z = −2.344, p = 0.019, 2-tailed Related samples Wilcoxon Signed Ranks Test). The average acuity gain was 0.14 logMAR equivalent (t(17) = 0.13, p &lt; 0.001, 2-tailed paired samples t-test). The averaged stereo acuity gain was 253 arc seconds (z = −2.689, p = 0.007). Based on more recent research concerning adult ocular dominance plasticity, contrary to current practice, patching the amblyopic eye makes more sense; comparable acuity benefits, better compliance, better binocular outcome and applicable to adults as well as old children.
BCG vaccinations drive epigenetic changes to the human T cell receptor: Restored expression in type 1 diabetes (2022)

The BCG (Bacille Calmette-Guérin) vaccine, introduced 100 years ago for tuberculosis prevention, has emerging therapeutic off-target benefits for autoimmunity. In randomized controlled trials, BCG vaccinations were shown to gradually improve two autoimmune conditions, type 1 diabetes (T1D) and multiple sclerosis. Here, we investigate the mechanisms behind the autoimmune benefits and test the hypothesis that this microbe synergy could be due to an impact on the host T cell receptor (TCR) and TCR signal strength. We show a quantitative TCR defect in T1D subjects consisting of a marked reduction in receptor density on T cells due to hypermethylation of TCR-related genes. BCG corrects this defect gradually over 3 years by demethylating hypermethylated sites on members of the TCR gene family. The TCR sequence is not modified through recombination, ruling out a qualitative defect. These findings support an underlying density defect in the TCR affecting TCR signal strength in T1D.
Modeling nonlinearity in coherent transmissions with dominant intrachannel-four-wave-mixing (2012)

By extending a well-established time-domain perturbation approach to dual-polarization propagation, we provide an analytical framework to predict the nonlinear interference (NLI) variance, i.e., the variance induced by nonlinearity on the sampled field, and the nonlinear threshold (NLT) in coherent transmissions with dominant intrachannel-four-wave-mixing (IFWM). Such a framework applies to non dispersion managed (NDM) very long-haul coherent optical systems at nowadays typical baudrates of tens of Gigabaud, as well as to dispersion-managed (DM) systems at even higher baudrates, whenever IFWM is not removed by nonlinear equalization and is thus the dominant nonlinearity. The NLI variance formula has two fitting parameters which can be calibrated from simulations. From the NLI variance formula, analytical expressions of the NLT for both DM and NDM systems are derived and checked against recent NLT Monte-Carlo simulations.
An ATP-Dependent Ligase with Substrate Flexibility Involved in Assembly of the Peptidyl Nucleoside Antibiotic Polyoxin (2018)

Polyoxin (POL) is an unusual peptidyl nucleoside antibiotic, in which the peptidyl moiety and nucleoside skeleton are linked by an amide bond. However, their biosynthesis remains poorly understood. Here, we report the deciphering of PolG as an ATP-dependent ligase responsible for the assembly of POL. A <i>polG</i> mutant is capable of accumulating multiple intermediates, including the peptidyl moiety (carbamoylpolyoxamic acid [CPOAA]) and the nucleoside skeletons (POL-C and the previously overlooked thymine POL-C). We further demonstrate that PolG employs an ATP-dependent mechanism for amide bond formation and that the generation of the hybrid nucleoside antibiotic POL-N is also governed by PolG. Finally, we determined that the deduced ATP-binding sites are functionally essential for PolG and that they are highly conserved in a number of related ATP-dependent ligases. These insights have allowed us to propose a catalytic mechanism for the assembly of peptidyl nucleoside antibiotic via an acyl-phosphate intermediate and have opened the way for the combinatorial biosynthesis/pathway engineering of this group of nucleoside antibiotics.<b>IMPORTANCE</b> POL is well known for its remarkable antifungal bioactivities and unusual structural features. Actually, elucidation of the POL assembly logic not only provides the enzymatic basis for further biosynthetic understanding of related peptidyl nucleoside antibiotics but also contributes to the rational generation of more hybrid nucleoside antibiotics via synthetic biology strategy.
Wafer-Scale Hybrid Integration of InP DFB Lasers on Si Photonics by Flip-Chip Bonding with sub-300nm Alignment Precision (2022)

InP DFB lasers are flip-chip bonded to 300mm Si photonic wafers using a pick-and-place tool with an advanced vision system, realizing high-precision and high-throughput passive assembly. By careful co-design of the InP-Si Photonics electrical, optical and mechanical interface, as well as dedicated alignment fiducials, sub-300nm post-bonding alignment precision is realized in a 25s cycle time. Optical coupling losses of -1.5±-0.5dB are achieved at 1550nm wavelength after epoxy underfill, with up to 40 mW of optical power coupled to the SiN waveguides on the Si photonics wafer. The bonding interface adds less than 10% to the series resistance of the laser diodes and post-bonding thermal resistance is measured to be 76K/W (or 27K.mm/W), mostly dominated by heat spreading resistance in the InP lasers as suggested by in-depth thermal modeling. Although the assembled lasers suffer from significant, unintentional optical backreflection from the fiber grating couplers used for optical characterization, laser linewidths well below 1MHz have been measured under specific drive conditions, as supported by a detailed laser noise analysis. Finally, we demonstrate the ability of bonded laser assemblies to pass early reliability tests.
Intuitive visualization method for locating off-screen objects inspired by motion perception in peripheral vision (2017)

This paper describes an intuitive user interface (UI) that guides and attracts a user's attention toward off-screen objects using a vibrating icon. Mobile augmented reality is often used for finding various annotations that are overlaid on a real world image, such as operating instructions for maintenance and inspection. However, owing to the limited scope of the device screen, it is difficult for the user to convey annotations located off-screen. In this work, we focused on motion perception and cognition properties and attempted to show off-screen information intuitively using a simple approach. To achieve the intuitive off-screen information display, we used the motion of a small, circular, vibrating icon. Experiments with tasks involving locating an off-screen target and memorizing numbers were conducted to evaluate the usability of the proposed guidance UI. The results show that users using the proposed UI can locate a target more quickly, memorize numbers more precisely, and provided a high user satisfaction more easily, than with other conventional guidance UIs.
Assessing the Stochastic Intermittency of Single Quantum Dot Luminescence for Robust Quantification of Biomolecules (2013)

Single molecule detection schemes promise that one has the ability to reach the ultimate limit of detection: one molecule. In this paper, we use the stochastic luminescence of single semiconductor nanocrystals (quantum dots, QDs) to detect and localize particles as digital counts. These digital counts can be correlated to the concentration of analytes in solution. Here, we use total internal reflection fluorescence (TIRF) microscopy to probe individual QDs immobilized on a functionalized substrate. QDs have found their niche in the bioanalytical community due to their remarkable brightness and stability. Despite their numerous outstanding photophysical properties, QDs at the single particle level display a pronounced intermittent luminescence, posing a challenge for the detection of individual particles. In this paper, we demonstrate a reliable method for detecting QDs that takes advantage of these signal fluctuations by comparing the variations in the QD's fluorescence signals against variations of the background signal. The quantitative methodology developed here results in signal-to-background ratios up to 90:1, which is at least 8-times higher than the ratios obtained using methodologies relying solely on signal integration. This enhanced signal-to-background ratio facilitates a robust thresholding process and results in femtomolar limits of detection.
Towards 15% energy conversion efficiency: a systematic study of the solution-processed organic tandem solar cells based on commercially available materials (2013)

Owing to the lack of scalable high performance donor materials, studies on mass-produced organic photovoltaic (OPV) devices lag far behind that on lab-scale devices. In this work, we choose 6 already commercially available conjugated polymers and systematically investigate their potential in organic tandem solar cells. All the devices are processed under environmental conditions using doctor-blading, which is highly compatible with mass-production coating technologies. Power conversion efficiencies (PCE) of 6–7% are obtained for OPV devices based on different active layers. Optical simulations based on experimental data are performed for all realized tandem solar cells. An efficiency potential of ∼10% is estimated for these compounds in combination with phenyl-C61-butyric acid methyl ester (PCBM) as an acceptor. In addition, we assume a hypothetical, optimized acceptor to understand the limitation of donors. It is suggested that a PCE of >14% is realistic for tandem solar cells based on these commercially available donor materials. Along with the demonstration of novel intermediate layers we believe that this systematic study provides valuable insight for those attempting to realize the high efficiency potential of tandem architectures.