gebhart/patrepeval huggingface dataset:
The Incidence and Possible Relevance of Y-Linked Microdeletions in Babies Born After Intracytoplasmic Sperm Injection and Their Infertile Fathers (1998)

No AccessJournal of UrologyUrological Survey: Abstracts: Male Infertility1 Feb 1998The Incidence and Possible Relevance of Y-Linked Microdeletions in Babies Born After Intracytoplasmic Sperm Injection and Their Infertile Fathers M.G. Kent-First, S. Kol, A. Muallem, R. Ofir, D. Manor, S. Blazer, N. First, and J. Itskovitz-Eldor M.G. Kent-FirstM.G. Kent-First More articles by this author , S. KolS. Kol More articles by this author , A. MuallemA. Muallem More articles by this author , R. OfirR. Ofir More articles by this author , D. ManorD. Manor More articles by this author , S. BlazerS. Blazer More articles by this author , N. FirstN. First More articles by this author , and J. Itskovitz-EldorJ. Itskovitz-Eldor More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)63892-8AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "The Incidence and Possible Relevance of Y-Linked Microdeletions in Babies Born After Intracytoplasmic Sperm Injection and Their Infertile Fathers." The Journal of Urology, 159(2S), pp. 609–610 Promega Corporation, Department of Meat and Animal Science, University of Wisconsin, Madison, Wisconsin and Department of Obstetrics and Gynecology, and Neonatology, Rambam Medical Center and Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.© 1998 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 159Issue 2SFebruary 1998Page: 609-610 Advertisement Copyright & Permissions© 1998 by American Urological Association, Inc.MetricsAuthor Information M.G. Kent-First More articles by this author S. Kol More articles by this author A. Muallem More articles by this author R. Ofir More articles by this author D. Manor More articles by this author S. Blazer More articles by this author N. First More articles by this author J. Itskovitz-Eldor More articles by this author Expand All Advertisement PDF downloadLoading ...
Thermal Conductivities, Rheological Behaviors and Photothermal Properties of Ethylene Glycol-based Nanofluids Containing Carbon Black Nanoparticles (2012)

Nanofluid is a new class of heat transfer fluids containing nano-sized particles, fibers, or tubes that are stably suspended in a carrier liquid. In this article, carbon black nanofluids were prepared by dispersing the pre-treated carbon black powder into ethylene glycol. The thermal conductivities, rheological behaviors and photo-thermal properties of the nanofluids were investigated. The results showed that the thermal conductivities of carbon black nanofluids increased with particle loading and temperature. The nanofluids performed a shear thinning behavior. The shear viscosity increased with particle loading while decreased with temperature at the same shear rate. Carbon black nanofluids had good absorption ability of solar energy and could effectively enhance the solar absorption efficiency.
GPS C/N/sub 0/ estimation in the presence of interference and limited quantization levels (2007)

The carrier-to-noise density ratio (C/N0) is considered an important parameter describing the GPS receiver performance. This paper compares the performance of two popular coarse-acquisition (C/A) C/N0 algorithms appearing in literature: the variance summing method (VSM) (Psiaki et al., 2003, Psiaki, 2001), and the power ratio method (PRM) (Van Dierendonck, 1996, Sayre, 2003), in terms of their estimates in 1) additive white Gaussian noise (AWGN), 2) narrowband continuous wave interference (CWI), 3) their response to quantization and saturation effects, and their 4) dynamic range. The algorithms were implemented as a part of a software receiver. Two LI GPS data sets are examined; one was obtained from a GPS raw data collection setup, while the other was obtained from a GPS signal simulator. The collected set was stored with almost constant C/N0 level while the simulated one contained variable C/N0 levels. The effect of adding AWGN on the C/N0 estimate was directly proportional with the noise power. The C/N0 estimates suffered more when the CWI frequency was closer to the IF of the receiver. The PRM suffered from saturation at higher C/N0 levels. The VSM showed good tracking at high C/N0 levels and better immunity to limited quantization levels, while its C/N0 estimate suffered from rapid fluctuations in power levels when sudden power steps occurred
Ca2+ in the first epidermal growth factor-like domain of activated factor VII. (1998)

Activated factor VII (FVIIa) needs to be bound to tissue factor (TF) to express biological activity, and biochemical and structural data show that the first epidermal growth factor (EGF)-like domain of FVIIa contributes essential contacts with TF. To investigate the role of Ca2+ binding to this domain in FVIIa we used site-directed mutagenesis to replace Asp46 and Asp63 by Asn, which abolished Ca2+ binding, and characterized the double mutant (D46,63N-FVIIa) with respect to its TF-binding properties and the functional status of its complex with TF. D46,63N-FVIIa had a lower amidolytic activity than FVIIa at optimal Ca2+ concentrations. A slightly lower amidolytic activity was also observed in complex with soluble TF, apparently due to a lower catalytic turnover rate of D46,63N-FVIIa. However, D46,63N-FVIIa and FVIIa bound to lipidated TF were equally efficient activators of factor X. The dissociation constant for the interaction between D46,63N-FVIIa and soluble TF, derived from amidolytic activity and direct binding measurements, was approximately 20-fold higher than that for the interaction between FVIIa and soluble TF. The same difference was observed in the affinity for lipidated TF. These findings suggest that a functional Ca2+-binding site in the first EGF-like domain adds approximately 7 kJ/mol to the total binding energy of the interaction with both lipidated and soluble TF.
INHERITANCE AND IMPROVEMENT OF COLD TOLERANCE TRAITS IN MAIZE. (1978)

Abstract not available
Bimatoprost: Mechanism of Ocular Surface Hyperemia Associated with Topical Therapy (2006)

Bimatoprost is a safe and well-tolerated intraocular pressure (IOP) lowering drug that was approved in the United States in 2001 for the treatment of glaucoma and ocular hypertension. It is highly efficacious and produces greater mean reductions in IOP than other currently available antiglaucoma drugs. Conjunctival hyperemia is a common side effect of bimatoprost, but the hyperemia is typically mild and transient. No association has been found between signs of inflammation and the presence of hyperemia in bimatoprost-treated patients. Preclinical studies have elucidated the pharmacological mechanism of bimatoprost-related hyperemia and have examined the possible involvement of inflammation. Bimatoprost, as well as the free acid of latanoprost, elicited endothelium-de-pendent vasorelaxation in the rabbit jugular vein preparation, a quantitative in vitro model for ocular surface hyperemia (OSH). The vasorelaxant responses to either bimatoprost or latanoprost free acid were significantly inhibited by L-NAME, a nitric oxide synthase inhibitor. Similarly, the in vivo OSH responses to topically applied bimatoprost or latanoprost in dog eyes were significantly inhibited by L-NAME. As predicted, prostaglandin E2 (PGE2)-induced conjunctival hyperemia was not inhibited by L-NAME, since PGE2 has a direct relaxant effect on the vascular smooth muscle. In-life observations and histopatho-logical assessment of ocular surface tissues following bimatoprost treatment were performed for multiple-dose one month, 6 month, or 12 month safety studies in rabbits, dogs, and non-human primates. Results of these studies showed no evidence of bimatoprost-re-lated inflammation in the ocular surface tissues. In summary, OSH related to bimatoprost treatment in laboratory animals occurs by endothelial-derived nitric oxide-mediated vasodilatation and is not associated with inflammation. These studies suggest that conjunctival hyperemia, a side effect of bimatoprost treatment, results from non-inflammatory, pharmacologically based vasodilatation.
1 Gbit/s CMOS photoreceiver with integrated detectoroperating at 850 nm (1998)

A fully integrated single-beam optical receiver is realised in a production 0.35 µm CMOS process, which operates at 850 nm to 1 Gbit/s. The receiver integrates a photodiode, preamplifier, digital logic, and an off-chip driver. Pre-amplifier dissipation is &lt; 1.5 mW at 2.3 V, with an average optical power of –6.3 dBm required for 1 Gbit/s operation. Such a compact optical receiver may be of interest for short distance optical interconnects or local area networks.
Catalytic Synthesis of Isoquinolines via Intramolecular Migration of N-Aryl Sulfonyl Groups on 1,5-Yne-Imines (2019)

Abstract Isoquinolines are ubiquitous structural motifs in a variety of bioactive compounds, including medicinal agents and natural products. The development of novel strategies for the preparation of isoquinolines using non-toxic organocatalysts is thus worthwhile. Herein, we report a simple amine-catalyzed protocol for the synthesis of isoquinolines from 1,5-yne-imines via the intramoleular migration of an N-aryl sulfonyl group to the carbon atom of the alkyne moiety.
Modeling Techniques to Support Fuel Path Control in Medium Duty Diesel Engines (2010)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;In modern production diesel engine control systems, fuel path control is still largely conducted through a system of tables that set mode, timing and injection quantity and with common rail systems, rail pressure. In the hands of an experienced team, such systems have proved so far able to meet emissions standards, but they lack the analytical underpinning that lead to systematic solutions.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;In high degree of freedom systems typified by modern fuel injection, there is substantial scope to deploy optimising closed loop strategies during calibration and potentially in the delivered product. In an optimising controller, a digital algorithm will explicitly trade-off conflicting objectives and follow trajectories during transients that continue to meet a defined set of criteria.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;Such an optimising controller must be based on a model of the system behaviour which is used in real time to investigate the consequences of proposed control actions. Models are critical to success, during design and operation of the control system.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;The formulation of model structure required in the investigation of fuel path has two aspects: linear models to be used in multi-model control schemes, and nonlinear models required to support the control design process. Experimental conditions are designed to collect data for model fitting and to collect data for validation. Special purpose engine controls were designed and implemented in order to support data collection and with a view to testing the resulting control systems. The results demonstrate that the modeling of fuel path is feasible to support both control design and the real time operation of the closed loop control of the fuel path devices.&lt;/div&gt;&lt;/div&gt;
Guest Editorial: Special Section on the Third IEEE International Workshop on Applied Measurements for Power Systems (AMPS) Aachen, Germany, September 26-28, 2012 (2013)

The seven papers in this special section are extended versions of papers presented at the Third IEEE International Workshop on Applied Measurements for Power Systems (AMPS), held in Aachen, Germany, September 26-28, 2012.
Supplementary Figure 5 from Extracorporeal Photochemotherapy Drives Monocyte-to-Dendritic Cell Maturation to Induce Anticancer Immunity (2023)

&lt;p&gt;Additional data for Figure 3, showing representative tumor growth data with tumor volumes to complement Figure 3A, as well as the full panel of soluble analytes examined by Luminex, to complement Figure 3C and D, for review and publication&lt;/p&gt;
Complement activation in diabetes mellitus. (1991)

To see whether or not there is complement activation in patients with diabetes mellitus, we investigated the plasma concentrations of C4, C3, C4a, C3a and SC5b-9 in either juvenile or adult onset insulin-dependent (IDDM) and non-insulin-dependent (NIDDM) diabetic patients at least 2 years after diagnosis. C4, C3, SC5b-9 plasma levels were not significantly different in IDDM and NIDDM patients than in age-matched controls. Anaphylatoxin peptide conversion product C4a, but not C3a, was found significantly higher in adult-onset IDDM patients than in patients with juvenile onset IDDM, NIDDM patients and age-matched controls. Complement activation did not appear to be correlated with the metabolic control, nor the duration of disease nor the presence of circulating antibodies (including islet cells (ICA), insulin (IA), thyroid microsomal (TMA), and thyroglobulin (TGA)). Although there are many factors that may trigger complement activation, we found the highest levels of C4a in elderly subjects (both diabetics and control subjects) and particularly in those who had clinically detectable vascular complications.
The AURORA initiative for metastatic breast cancer (2014)

Metastatic breast cancer is one of the leading causes of cancer-related mortality among women in the Western world. To date most research efforts have focused on the molecular analysis of the primary tumour to dissect the genotypes of the disease. However, accumulating evidence supports a molecular evolution of breast cancer during its life cycle, with metastatic lesions acquiring new molecular aberrations. Recognising this critical gap of knowledge, the Breast International Group is launching AURORA, a large, multinational, collaborative metastatic breast cancer molecular screening programme. Approximately 1300 patients with metastatic breast cancer who have received no more than one line of systemic treatment for advanced disease will, after giving informed consent, donate archived primary tumour tissue, as well as will donate tissue collected prospectively from the biopsy of metastatic lesions and blood. Both tumour tissue types, together with a blood sample, will then be subjected to next generation sequencing for a panel of cancer-related genes. The patients will be treated at the discretion of their treating physicians per standard local practice, and they will be followed for clinical outcome for 10 years. Alternatively, depending on the molecular profiles found, patients will be directed to innovative clinical trials assessing molecularly targeted agents. Samples of outlier patients considered as 'exceptional responders' or as 'rapid progressors' based on the clinical follow-up will be subjected to deeper molecular characterisation in order to identify new prognostic and predictive biomarkers. AURORA, through its innovative design, will shed light onto some of the unknown areas of metastatic breast cancer, helping to improve the clinical outcome of breast cancer patients.
Trellis-based circle detection (2008)

We introduce a new method for finding circles in images. The proposed method assumes a given pixel is the center of a prospective circle, attempts to fit a circle at that location to the data, and then it scans over all possible pixels. The score at each assumed center location is found by traversing a trellis structure. The trellis allows for gaps in the prospective circles and it enforces a global all or none constraint. The proposed method is compared to a binary matched filter using real visible-spectrum aerial images, where the targets are the circular-shaped silos of surface-to-air missile sites. The proposed method performs noticeably better than the binary matched filter for the data used in this study.
Neuropeptidomics of the Mosquito Aedes aegypti (2010)

Neuropeptidomic data were collected on the mosquito Ae. aegypti, which is considered the most tractable mosquito species for physiological and endocrine studies. The data were solely obtained by direct mass spectrometric profiling, including tandem fragmentation, of selected tissues from single specimens, which yielded a largely complete accounting of the putative bioactive neuropeptides; truncated neuropeptides with low abundance were not counted as mature peptides. Differential processing within the CNS was detected for the CAPA-precursor, and differential post-translational processing (pyroglutamate formation) was detected for AST-C and CAPA-PVK-2. For the first time in insects, we succeeded in the direct mass spectrometric profiling of midgut tissue which yielded a comprehensive and immediate overview of the peptides involved in the endocrine system of the gut. Head peptides which were earlier identified as the most abundant RFamides of Ae. aegypti, were not detected in any part of the CNS or midgut. This study provides a framework for future investigations on mosquito endocrinology and neurobiology. Given the high sequence similarity of neuropeptide precursors identified in other medically important mosquitoes, conclusions regarding the peptidome of Ae. aegypti likely are applicable to these mosquitoes.
Integrated Sensing Systems for Monitoring Interrelated Physiological Parameters in Young and Aged Adults (2021)

Acute injury to aged individuals represents a significant challenge to the global healthcare community as these injuries are frequently treated in a reactive method due to the infeasibility of frequent visits to the hospital for biometric monitoring. However, there is potential to prevent a large number of these cases through passive, at-home monitoring of multiple physiological parameters related to various causes that are common to aged adults in general. This research strives to implement wearable devices, ambient “smart home” devices, and minimally invasive blood and urine analysis to test the feasibility of implementation of a multitude of research-level (i.e. not yet clinically validated) methods simultaneously in a “smart system”. The system comprises measures of balance, breathing, heart rate, metabolic rate, joint flexibility, hydration, and physical performance functions in addition to lab testing related to biological aging and mechanical cell strength. A proof-of-concept test is illustrated for two adult males of different ages: a 22-year-old and a 73-year-old matched in body mass index (BMI). The integrated system is test in this work, a pilot study, demonstrating functionality and age-related clinical relevance. The two subjects had physiological measurements taken in several settings during the pilot study: seated, biking, and lying down. Balance measurements indicated changes in sway area of 45.45% and 25.44%, respectively for before/after biking. The 22-year-old and the 73-year-old saw heart rate variabilities of 0.11 and 0.02 seconds at resting conditions, and metabolic rate changes of 277.38% and 222.23%, respectively, in comparison between the biking and seated conditions. A smart camera was used to assess biking speed and the 22- and 73-year-old subjects biked at 60 rpm and 28.5 rpm, respectively. The 22-year-old subject saw a 7 times greater electrical resistance change using a joint flexibility sensor inside of their index finger in comparison with the 73-year-old male. The 22 and 73-year-old males saw respective 28% and 48% increases in their urine ammonium concentration before/after the experiment. The average lengths of the telomere DNA from the two subjects were measured to be 12.1 kb (22-year-old) and 6.9 kb (73-year-old), consistent with their biological ages. The study probed feasibility of 1) multi-metric assessment under free living conditions, and 2) tracking of the various metrics over time.
Comparison of High, Intermediate, and Low Frequency Shock Wave Lithotripsy for Urinary Tract Stone Disease: Systematic Review and Network Meta-Analysis (2016)

Intermediate- and low-frequency SWL have better treatment outcomes than high-frequency SWL when considering both efficacy and complication.
Extending the Cooling Limit of Remote Radio Head (RRH) Systems Based on Level 1 Thermal Management (2018)

The evolution of wireless networks from 3G/4G to 5G will significantly increase the bandwidth, capacity and capability of these systems. To address these growing requirements, chip manufacturers are using aggressive node scaling coupled with tighter SoC integration to deliver the promises of the next generation network without negatively impacting system power. The combination of these techniques contribute to the breakdown of Dennard Scaling and result in higher power and thermal densities per device as we integrate more circuitry into smaller areas demanding a greater challenge to existing thermal design techniques and driving changes to this development. This paper will explore one such change using a lidless package paired with an innovative surface and mounting method to address this growing power density paradigm.
Two-photon absorption cross sections of guanosine 5'-monophosphate and uridine 5'-monophosphate at 532 nm (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTwo-photon absorption cross sections of guanosine 5'-monophosphate and uridine 5'-monophosphate at 532 nmIvo G. Gut, Yaron Hefetz, Irene E. Kochevar, and Franz HillenkampCite this: J. Phys. Chem. 1993, 97, 19, 5171–5176Publication Date (Print):May 1, 1993Publication History Published online1 May 2002Published inissue 1 May 1993https://pubs.acs.org/doi/10.1021/j100121a053https://doi.org/10.1021/j100121a053research-articleACS PublicationsRequest reuse permissionsArticle Views200Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Expression during Salt Stress and Nucleotide Sequence of cDNA for Ferredoxin-NADP+ Reductase from Mesembryanthemum crystallinum (1989)

In the facultative halophyte Mesembryanthemum crystallinum (common ice plant) the enzyme ferredoxin-NADP(+)-reductase (FNR) is coded for by a small family of 2 to 3 genes. We have determined the expression characteristics as the plants adapt to high salt and the nucleotide sequence of a full-length cDNA coding for the precursor of this chloroplast-located enzyme. On a developmental scale amounts of FNR transcripts and protein are highest in young emerging leaves. The FNR cDNA is a member of a class of genes whose expression is only slightly affected by salt stress. Even less pronounced than mRNA fluctuations, the amount of FNR protein is unaffected by salt stress. The longest FNR cDNA found was 1,419 nucleotides in size. It consisted of 74 nucleotides 5'-leader sequence, 1,095 nucleotides of protein coding sequence encoding 365 amino acids, and 247 nucleotides 3-region excluding a short poly(A(+)) tail. As expected for a nucleus-coded chloroplast protein an amino terminal transit peptide (52 amino acids in length) was found. The mature FNR protein is predicted to contain 313 amino acids corresponding to a protein of M(r) 35,713. The deduced amino acid sequence of the mature FNR protein is 93.2 and 85.9% identical to those of spinach and pea. The transit peptide of pea and spinach have 55.8 and 69.2% identity with that from ice plant.