gebhart/patrepeval huggingface dataset:
Severe toxicity limits intensification of induction therapy for acute lymphoblastic leukemia. (1993)

Fourteen adult patients with newly-diagnosed acute lymphoblastic, leukemia (ALL), and lymphoblastic lymphoma, were treated with a dose-intense induction regimen. This regimen was designed to increase the fraction of patients achieving an early complete remission, in an attempt to increase the fraction of patients who are long-term disease-free survivors. The induction regimen included vincristine, prednisone, intermediate-dose cytarabine (Ara-C), and idarubicin, all given during the first week of therapy. This combination led to significant hepatic, gastro-intestinal, infectious, and neurologic toxicity. There was unacceptable treatment-related mortality (29%). After the first eight patients, the study was modified, omitting the Ara-C from the induction phase. Gastrointestinal morbidity was less in the cohort treated without Ara-C; however, infectious morbidity persisted at unacceptable levels and this program was terminated as too toxic to administer. There were nine complete remissions, three early deaths, and two patients with resistant disease. There have been six relapses, three of which occurred in patients who, because of protracted grade III/IV toxicity, were no longer receiving chemotherapy. With a minimum follow-up of 20 months, only three patients are still alive. We conclude that this combination of vincristine, prednisone, Ara-C, and idarubicin, is too toxic to be used as induction therapy for adult patients with ALL and lymphoblastic lymphoma.
Integrated AO space-division optical crossbar (1994)

An integrated acousto optic (AO) implementation of an optical crossbar for fiber-network systems is presented.1,2 This space-division switching configuration can permute as many as 12 single-mode fiber inputs to outputs without having fan-in and fan-out losses that plague other passive 3D optical-interconnection techniques.3 Other routing functions of a crossbar, such as broadcast and fan-in, can also be performed by simply changing the driving signals. The bidirectional switching system permits the transmission of signals of arbitrary formats and band- widths as wide as 100 GHz by avoiding any optical —electronic conversion. The reconfiguration time is limited by the aperture time of the AO Bragg cell, which is of the order of a few microseconds.
Charged Push−Pull Polyenes in Solution:  Anomalous Solvatochromism and Nonlinear Optical Properties (2003)

The linear and nonlinear optical properties of charged push−pull polyenes (CPPP) are, respectively, of interest in connection with unusual linear spectroscopic solvatochromic behavior in solution and other polar media and applications ranging from second harmonic generation to imaging and probing of biological systems. The CPPP are charged conjugated quasi-one-dimensional molecules containing an electron-donating group (D) and an electron-acceptor group (A) interacting via a π-conjugated bridge. Here we present a theoretical description for photoinduced charge transfer for such molecules in solution, based on a two valence bond state electronic description together with inclusion of a geometrical coordinate for the bridge and a solvent coordinate describing nonequilibrium solvation of the molecule. The theory both accounts for the anomalous linear solvatochromic behavior and provides a treatment of CPPP nonlinear optical properties in solution.
URANS modelling of pulsed turbulent jets and premixed jet flames (2005)

The formation of self-excited pressure oscillations in technical combustion systems depends on the dynamical behaviour of the flames used. One goal of future combustor development is the prediction of combustion instabilities during the design process. The first aim of the work was to calculate the flame transfer function of forced flames with CFD codes using 'Unsteady-Reynolds-Averaged-Navier-Stokes' approaches. Pulsed isothermal turbulent jets as well as pulsed premixed jet flames with different thermal loads (20/40/60 kW) were modelled using forcing frequencies of up to 200 Hz. Three different versions of the κ-ε turbulence model and a 'Turbulent-Flamespeed-Closure' combustion model were applied. A variation of discretisation schemes and turbulent diffusion allowed the estimation of numerical errors. An important mechanism driving combustion instabilities is the interaction of the flame with large-scale ring vortices. The second aim was to investigate how the interaction works to get more insight and understanding of this phenomenon. The results obtained were validated against experimental data.
The Human Herpesvirus 6 G Protein-Coupled Receptor Homolog U51 Positively Regulates Virus Replication and Enhances Cell-Cell Fusion In Vitro (2005)

Human herpesvirus 6 (HHV-6) is a ubiquitous T-lymphotropic betaherpesvirus that encodes two G protein-coupled receptor homologs, U12 and U51. HHV-6A U51 has been reported to bind to CC chemokines including RANTES, but the biological function of U51 remains uncertain. In this report, we stably expressed short interfering RNAs (siRNAs) specific for U51 in human T cells and then infected these cells with HHV-6. Viral DNA replication was reduced 50-fold by the U51 siRNA, and virally induced cytopathic effects were also inhibited. In contrast, viral replication and syncytium formation were unaltered in cells that expressed a scrambled derivative of the siRNA or an irrelevant siRNA and were restored to normal when a human codon-optimized derivative of U51 was introduced into cells containing the U51 siRNA. To examine the mechanism whereby U51 might contribute to viral replication, we explored the signaling characteristics of U51. None of the chemokines and opioids tested was able to induce G protein coupling by U51, and no evidence for opioid ligand binding by U51 was obtained. The effect of U51 on cell-cell fusion was also evaluated; these studies showed that U51 enhanced cell fusion mediated by the G protein of vesicular stomatitis virus. However, a U51-specific antiserum had no virus-neutralizing activity, suggesting that U51 may not be involved in the initial interaction between the virus particle and host cell. Overall, these studies suggest that HHV-6 U51 is a positive regulator of virus replication in vitro, perhaps because it may promote membrane fusion and facilitates cell-cell spread of this highly cell-associated virus.
Effects of multipath-induced angular spread on directions of arrival estimators in array signal processing (1995)

Effects of multipath-induced angular spread on directions of arrival estimators in array signal processing
Formale enantioselektive Michael-Addition mit Umpolung der Reaktivität (2001)

Nach einer Sequenz aus asymmetrischer Hydroborierung, Bor-Zink-Austausch und Transmetallierung auf Kupfer können ungesättigte Ketale und Acetale mit guten Enantioselektivitäten allyliert, alkinyliert und allenyliert werden (siehe Schema; (−)-IpcBH2=(−)-Isopinocampheylboran, TMS=Me3Si). Die Produkte entsprechen denen einer formalen Michael-Addition unter Umpolung der Reaktivität. Hintergrundinformationen zu diesem Beitrag sind im WWW unter http://www.wiley-vch.de/contents/jc_2001/2001/z16903_s.pdf zu finden oder können beim Autor angefordert werden. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Patterning PEDOT:PSS with Parylene Peel-off Method (2010)

We have developed and characterized a technique of patterning PEDOT:PSS (poly(3,4-ethylenedioxythiophene): polystyrenesulfonate) film with a Parylene peel-off method. PEDOT:PSS has characteristics of transparency and high conductivity which are expected to replace transparent ITO (indium tin oxide) electrodes for flat panel displays. But existing technology of inkjet printing decreased its conductivity by mixing a binder, while the other method with electrochemical etching could not completely remove PEDOT:PSS film. To solve these problems, we proposed a process which consisted of negative patterning of Parylene film, coating of PEDOT:PSS and peeling off of Parylene film with the undesired-area of PEDOT:PSS. To peel off the Parylene from the substrates, the control of heating process of PEDOT:PSS under Parylene glass transition temperature was found to be required. The proposed process revealed that the conductivity was almost the same even after the process and its resolution reached down to 20 μm. Finally, the 300-μm-wide electrodes were fabricated through the process, which leads to replacement of ITO for displays.
STT-MRAM Product Reliability and Cross-Talk (2022)

STT-MRAM has been showcased to be a viable solution to replace eFlash and SRAM technologies. With the increasing demand for connected edge computing and internet of things, the usage of STT-MRAM in MCU and MPU products has become the reality. The product reliability of industrial-grade (-40~125°C) 40Mb 22FDX <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">®</sup> embedded-MRAM technology having 5x-solder reflows compatibility stack is presented. The stand-by magnetic immunity and cross-talk between MRAM and RF are also discussed.
Dark energy and the return of the phoenix universe (2009)

In cyclic universe models based on a single scalar field (e.g., the radion determining the distance between branes in M theory), virtually the entire Universe makes it through the ekpyrotic smoothing and flattening phase, bounces, and enters a new epoch of expansion and cooling. This stable evolution cannot occur, however, if scale-invariant curvature perturbations are produced by the entropic mechanism because it requires two scalar fields (e.g., the radion and the Calabi-Yau dilaton) evolving along an unstable classical trajectory. In fact, we show here that an overwhelming fraction of the Universe fails to make it through the ekpyrotic phase; nevertheless, a sufficient volume survives and cycling continues forever provided the dark energy phase of the cycle lasts long enough, of order a trillion years. Two consequences are a new role for dark energy and a global structure of the Universe radically different from that of eternal inflation.
Red Phosphorescent Material Doped in the Hole- and Electron-Transport Layer of Organic Light-Emitting Device (2006)

In this paper, we demonstrated a red phosphorescent organic light-emitting device with high efficiency and low driving-voltage (15.2 cd/A at 6 V with 1030 cd/m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ) by using hole- and electron-transport materials as the host of the emitting layer
Virtual-freezing fluorescence imaging flow cytometry (2020)

By virtue of the combined merits of flow cytometry and fluorescence microscopy, imaging flow cytometry (IFC) has become an established tool for cell analysis in diverse biomedical fields such as cancer biology, microbiology, immunology, hematology, and stem cell biology. However, the performance and utility of IFC are severely limited by the fundamental trade-off between throughput, sensitivity, and spatial resolution. Here we present an optomechanical imaging method that overcomes the trade-off by virtually freezing the motion of flowing cells on the image sensor to effectively achieve 1000 times longer exposure time for microscopy-grade fluorescence image acquisition. Consequently, it enables high-throughput IFC of single cells at >10,000 cells s<sup>-1</sup> without sacrificing sensitivity and spatial resolution. The availability of numerous information-rich fluorescence cell images allows high-dimensional statistical analysis and accurate classification with deep learning, as evidenced by our demonstration of unique applications in hematology and microbiology.
Inhibition of Mg activation in p-type GaN caused by thin AlGaN capping layer and impact of designing hydrogen desorption pathway (2021)

Thermal activation of a Mg-doped GaN layer with a thin AlGaN capping layer was investigated by means of systematic electrical characterization. Two-dimensional electron gas generated at the AlGaN/GaN interface greatly inhibited activation of the underlying Mg-doped GaN layer. This finding is attributed to the charge states of the interstitial hydrogen atoms being released from the Mg–H complexes and their diffusivity being dependent on the Fermi level position in GaN-based heterostructures. Reasonable electrically active acceptor concentration in Mg-doped GaN was achieved by designing a hydrogen desorption pathway.
Supplementary Table 4 from MAP Kinase Pathway Alterations in <i>BRAF</i>-Mutant Melanoma Patients with Acquired Resistance to Combined RAF/MEK Inhibition (2023)

&lt;p&gt;XLSX file 12K, Candidate Resistance Genes from RNAi and ORF Functional Screens&lt;/p&gt;
DABCOnium: Ein effizienter und Hochspannungs‐stabiler Singulett‐Sauerstoff‐Löscher für Metall‐O2‐Zellen (2019)

Abstract Singulett‐Sauerstoff ( 1 O 2 ) verursacht einen Großteil der parasitären Chemie während des Zellbetriebs von nichtwässrigen Alkalimetall‐O 2 ‐Batterien und trägt auch zur Grenzflächenreaktivität von Übergangsmetalloxid‐Einlagerungsverbindungen bei. Wir führen DABCOnium, die monoalkylierte Form von 1,4‐Diazabicyclo[2.2.2]octan (DABCO), als effizienten 1 O 2 ‐Löscher mit ungewöhnlich hoher Oxidationsstabilität von ≈4.2 V vs. Li/Li + ein. Bisher bekannte Löscher sind stark Lewis‐basische Amine mit zu geringer Oxidationsstabilität. DABCOnium ist eine ionische Flüssigkeit, nicht flüchtig, im Elektrolyten hochlöslich, stabil gegen Superoxid und Peroxid, und kompatibel mit Lithiummetall. Die elektrochemische Stabilität deckt den erforderlichen Bereich für Metall‐O 2 ‐Batterien ab und reduziert die 1 O 2 ‐bedingte parasitäre Chemie erheblich, wie für die Li‐O 2 ‐Zelle gezeigt wird.
A facile method to fabricate carbon nanostructures via the self-assembly of polyacrylonitrile/poly(methyl methacrylate-b-polyacrylonitrile) AB/B′ type block copolymer/homopolymer blends (2016)

The self-assembly and high temperature behavior of AB/B′ type block copolymer/homopolymer blends containing polyacrylonitrile (PAN) polymers were studied for the first time.
Notes and Comment Investigating locomotion abnonnalities in animal modelsof extrapyramidal disorders: A commentary (1984)

Diseases of the extrapyramidal system usually re­ sult in disorders of movement, and the location of the pathology within this system is critical in the ex­ pression of the type of movement disorder. For ex­ ample, Huntington's disease, which is characterized by degeneration of basal ganglia neurons, is ex­ pressed as abnormal involuntary movements (Sanberg & Coyle, in press), whereas, Parkinson's disease, in which there is a loss of the dopamine afferent system to the striatum, results in rigidity and bradykinesia (Barbeau, 1981). Furthermore, Tourette's syndrome, where a hypersensitivity of striatal dopamine recep­ tors has been postulated (Shapiro, Shapiro, & Wayne, 1973; Singer, Butler, Tune, Seifert, & Coyle, 1982), is characterized by chronic fluctuating motor tics and involuntary verbalizations (Singer, 1982). Thus, alter­ ations in the functions of the basal ganglia are evi­ dent in many movement disorders. Unfortunately, the role of this important group of telencephalic nu­ clei in behavior is little understood. Our research in­ terests have been in trying to understand this role for both the developing and mature striatum (Johnson & Becker, 1973; Polgar, Sanberg, & Kirkby, 1981; Sanberg, Pisa, & Fibiger, 1979). The research dis­ cussed here is concerned primarily with analyzing in detail the pattern of abnormal locomotion found in neonatal and adult rats with various types of striatal This research was supported by NS-18414, RSDA Type 11 MHOO125, and a grant from the Surdna Foundation to J,T.C., and by a Tourette Syndrome Association Research Fellowship, a Huntington's disease grant from the Pratt Family and Friends, and a grant from the Ohio University Research Council to P .R,S, The authors are grateful to Omnitech, Inc, (Columbus, Ohio) for the gift of Digiscan animal activity monitor equipment, P ,R.S. is associated with the Behavioral Neuroscience Laboratory and the Departments of Psychology and Biomedical Sciences, and D.A.J. is associated with the Behavioral NeuroscienceLaboratory and the Department of Psychology, both at Ohio University. T.H.M. is affiliated with the Department of Psychiatry and J,T.C. is asso­ ciated with the Departments of Psychiatry, Neuroscience, Phar­ macology, and Pediatrics of the Division of Child Psychiatry, both at the Johns Hopkins University School of Medicine.
Field-simulation-based strategy for designing microstrip filters (2003)

The insertion loss spectrum of a microstrip open-loop square ring band-pass filter is analyzed by using the Finite Difference Time Domain (FDTD) field simulations. Visualization of standing waves at resonant frequencies guides the placement of stepped impedance sections or capacitive loads at electric field maxima. Strategic load placement enables us to modify selected resonant modes, to monitor efficiently center and attenuation pole frequencies, to affect the shape and width of the pass-band, and to alter the input impedance. The presented approach is useful for miniaturizing various types of microstrip filters and antennas and optimizing their performance.
A multi-input modeling approach to quantify hippocampal nonlinear dynamic transformations (2006)

A multi-input modeling approach is introduced to quantify hippocampal neural dynamics. It is based on the Volterra modeling approach extended to multiple inputs. The computed Volterra kernels allow quantitative description of hippocampal transformations and define a predictive model that can produce responses to arbitrary input patterns. Electrophysiological data from several CA3 and CA1 cells in behaving rats were recorded simultaneously using an array of penetrating electrodes. This activity was used to compute kernels up to third order for single and multiple input cases. Representative sets of kernels illustrate the variability of the dynamics of the CA3-CA1 transformations. Our model's predictive accuracy was evaluated using ROC curves.
Assessment of the menstrual cycle upon total hemoglobin, water concentration, and oxygen saturation in the female breast (2003)

Near-infrared imaging can be used in humans to characterize changes in breast tumor tissue by imaging total hemoglobin and water concentrations as well as oxygen saturation. In order to improve our understanding of these changes, we need to carefully quantify the range of variation possible in normal tissues for these parameters. In this study, the effect of the subject’s menstrual cycle was examined by imaging their breast at the follicular (7-14 days of the cycle) and secretory phases (21-28 days of the cycle), using our NIR tomographic system. In this system, a three layer patient interface is used to measure 3 planes along the breast from chest wall towards the nipple at 1cm increments. Seven volunteers in their 40s were observed for 2 menstrual cycles and all of these volunteers recently had normal mammograms (ACR 1) with heterogeneously dense breast composition. The results show that average total hemoglobin in the breast increased in many subjects between 0 to 15% from the follicular phase to secretory phase. Oxygen saturation and water concentration changes between these 2 parts of the cycle were between &minus;6.5% to 12% for saturation and between &minus;33% to 28% for water concentration. While the data averaged between subjects showed no significant change existed between phases, it was clear that individual subjects did exhibit changes in composition which were consistent from cycle to cycle. Understanding what leads to this heterogeneity between subjects will be an important factor in utilizing these measurements in clinical practice.
In Vivo Pharmacologic Profile of ONO-1078: A Potent, Selective and Orally Active Peptide Leukotriene (LT) Antagonist. (1992)

We investigated the in vivo antagonistic activity of ONO-1078 against peptide leukotrienes (LTs) in guinea pigs. ONO-1078, when administered p.o. (0.3-3 mg/kg), caused a dose-dependent reduction of LTC4-, LTD4- and LTE4-induced bronchoconstriction, LTD4-induced airway microvascular leakage and LTD4-induced increase in cutaneous vascular permeability. When administered intravenously, ONO-1078 (3-30 micrograms/kg) inhibited these responses approximately 200-600 fold more potently than FPL55712. When guinea pigs were treated with indomethacin to examine the antagonism of ONO-1078 on the direct action against peptide LTs, intravenous (3-30 micrograms/kg) and oral (0.3-3 mg/kg) administration of ONO-1078 also inhibited LTC4- and LTD4-induced bronchoconstriction, and its activity was approximately 300-500 fold more potent than that of FPL55712. ONO-1078 (10 mg/kg, i.v.) had no inhibitory effect on bronchoconstrictions induced by histamine, acetylcholine, serotonin, arachidonic acid, LTB4, prostaglandin (PG) F2 alpha, PGD2, 9 alpha, 11 beta-PGF2, a stable thromboxane A2 mimetic agent and platelet activating factor. Furthermore, oral administration of ONO-1078 (1-10 mg/kg) inhibited slow-reacting substance of anaphylaxis mediated bronchoconstriction induced by antigen in a dose-dependent manner. These results indicate that ONO-1078 is an extremely potent, selective and orally active peptide LT antagonist and that oral administration of ONO-1078 antagonizes not only exogenously administered peptide LTs but also endogenous peptide LTs.
p53 mutations and occupational exposures in a surgical series of lung cancers. (1996)

p53 mutations are frequent in malignant lung tumors. Of 88 surgically treated lung cancers from cigarette smokers previously evaluated for p53 mutations, 45 tumors (51.1%) had mutations in exons 5-8 (D. G. Guinee, Jr. et al., Carcinogenesis (Lond.), 16: 993-1002, 1995). We report here the examination of 13 occupational exposures and 13 high-risk occupations in relation to these p53 mutations. Two molecular abnormalities were associated with occupational exposures: (a) G:C-->T:A transversions on the coding (nontranscribed) strand (n = 13) were associated with chromate exposure and employment in the metal industry (P < 0.05) and marginally associated with nickel exposure (P = 0.056); and (b) G:C-->A:T transitions at non-CpG sites (n = 9) were associated with work in the petrochemical industry (P = 0.05). No association was found between p53 mutations and gender, cigarette pack-years, tumor histology, age at diagnosis, or family history of lung cancer. Because all three chromate-exposed subjects had large cell carcinomas exhibiting G: C-->T:A coding-strand transversions, follow-up of a cohort with this exposure should clarify the association with the p53 gene.