gebhart/patrepeval huggingface dataset:
Long-term responses to thalidomide and rituximab in Waldenstrom's macroglobulinemia (2007)

8017 Background: Rituximab is active in Waldenstrom's macroglobulinemia (WM), producing response rates of 40–50%. Lower response rates are observed among patients with the FcγRIIIA-158 FF polymorphism; high B 2 M (≥3.0 mg/dL), and high serum IgM levels (≥6,000 mg/dL). Thalidomide enhances rituximab-mediated ADCC of lymphoplasmacytic cells and produces response rates of 25% in WM. As such, we conducted this phase II study using thalidomide and rituximab in patients naïve to either agent. Methods: Intended therapy was: Weeks 1–52: Thalidomide (200 mg po qHS for 2 wks, then 400 mg po qHS) Weeks 2–5, 13- 16: Rituximab (375 mg/m 2 /wk) Twenty-five patients were enrolled, 20 of whom were previously untreated, with a baseline median age of 62 (range 44–86 yrs), BM involvement of 40 (range 5–80%), serum IgM of 3,670 (range 924–8,610 mg/dL), B 2 M of 2.6 (range 1.4–8.3 mg/L), Hct of 34.1 (range 23.6–42.6%). Results: Grade ≥2 toxicities to thalidomide included neuroparesthesias (n=11); somnolence (n=3); confusion (n=3); rash (n=2); tremors (n=2); bradycardia (n=2) and palpitations (n=1). Among patients experiencing neuroparesthesias, 10 demonstrated resolution to grade 1 (n=3) or complete resolution (n=7) at a median of 6.7 (range 0.4- 22.5 months). Dose reduction of thalidomide occurred in all patients and led to discontinuation in 11 patients. Twenty-three patients were evaluable. Responses among evaluable patients: CR (n=1); PR (n=15); MR (n=2); SD (n=1) for an overall and a major response rate of 78% and 70%, respectively. Median serum IgM decreased from 3,670 (924–8,610 mg/dL) to 1,590 (36–5,230 mg/dL) (p&lt;0.001), while median hematocrit rose from 33.0 (23.6–42.6%) to 37.6 (29.3–44.3%) (p=0.004) at best response. With a median follow-up of 42+ months, the median TTP for all evaluable patients on study was 35 months, and 38+ months for responders. Overall response was associated with median cumulative thalidomide dose: CR/PR/MR (29,275 mg) vs. SD/NR (7,400 mg); p=0.004. Overall responses were unaffected by FcγRIIIA-158 polymorphism status (81% vs. 71% for VV/FV vs. FF); serum IgM (78% vs. 80% for &lt;6,000 vs. ≥6,000 mg/dL); and B 2 M levels (71% vs. 89% for &lt;3 vs. ≥3 g/dL); p=NS. Conclusions: Thalidomide in combination with rituximab is highly active and produces long- term responses in patients with WM. No significant financial relationships to disclose.
Publicly verifiable grouped aggregation queries on outsourced data streams (2013)

Outsourcing data streams and desired computations to a third party such as the cloud is a desirable option to many companies. However, data outsourcing and remote computations intrinsically raise issues of trust, making it crucial to verify results returned by third parties. In this context, we propose a novel solution to verify outsourced grouped aggregation queries (e.g., histogram or SQL Group-by queries) that are common in many business applications. We consider a setting where a data owner employs an untrusted remote server to run continuous grouped aggregation queries on a data stream it forwards to the server. Untrusted clients then query the server for results and efficiently verify correctness of the results by using a small and easy-to-compute signature provided by the data owner. Our work complements previous works on authenticating remote computation of selection and aggregation queries. The most important aspect of our solution is that it is publicly verifiable - unlike most prior works, we support untrusted clients (who can collude with other clients or with the server). Experimental results on real and synthetic data show that our solution is practical and efficient.
A Diverse Low Cost High Performance Platform for Advanced Driver Assistance System (ADAS) Applications (2016)

Advanced driver assistance systems (ADAS) are becoming more and more popular. Lot of the ADAS applications such as Lane departure warning (LDW), Forward Collision Warning (FCW), Automatic Cruise Control (ACC), Auto Emergency Braking (AEB), Surround View (SV) that were present only in high-end cars in the past have trickled down to the low and mid end vehicles. Lot of these applications are also mandated by safety authorities such as EUNCAP and NHTSA. In order to make these applications affordable in the low and mid end vehicles, it is important to have a cost effective, yet high performance and low power solution. Texas Instruments (TI's) TDA3x is an ideal platform which addresses these needs. This paper illustrates mapping of different algorithms such as SV, LDW, Object detection (OD), Structure From Motion (SFM) and Camera-Monitor Systems (CMS) to the TDA3x device, thereby demonstrating its compute capabilities. We also share the performance for these embedded vision applications, showing that TDA3x is an excellent high performance device for ADAS applications.
Microelectronics cooling and SEMI-THERM: a look back (2002)

For the occasion of the 10th anniversary of the SEMI-THERM conference, this paper provides a look back at some of the developments that have taken place since its founding. Topics covered include thermal measurement, thermal characterization, thermal analysis and modeling, air cooling, water cooling, and immersion cooling.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Antibody Response to Bacteriophage Hyaluronidase in Acute Glomerulonephritis After Group A Streptococcal Infection (1987)

In a test of the hypothesis that lysogeny of group A streptococci by a temperate bacteriophage might confer nephritogenicity, 283 sera from 69 patients were examined for IgG and IgM antibodies to M 49 streptococcal bacteriophage hyaluronidase. The IgG and IgM response to bacteriophage hyaluronidase was greatest in M 49 streptococci-infected individuals with nephritis, but M 49 streptococci-infected subjects without nephritis also had a greater immune response than did subjects infected with serotypes other than M 49. Although antibody to bacterial hyaluronidase was detected in all Streptococcus-infected groups, antibody to M 49 streptococcal bacteriophage hyaluronidase usually was found in only M 49 streptococci-infected patients. Although the greatest IgG and IgM antibody response to bacteriophage hyaluronidase can be demonstrated in individuals with glomerulonephritis, the antibody response does not indicate a direct relation of lysogeny and nephritis because subjects with and without nephritis after M 49 streptococcal infection all had a significant rise in antibody titer.
Inline cryogenic temperature sensors based on photonic crystal fiber Bragg gratings infiltrated with noble gases for harsh space applications (2007)

Summary form only given. In this paper, by infiltrating the microstructured holes of a PCF with a noble gas such as Krypton (Kr), which exhibits a drastic phase-change from gas to liquid at ultra-low temperatures as well as strong wavelength-dependent material dispersion characteristics, and by inscribing a BG of period into the PCF, we can succeed in utilizing a robust temperature sensor which can be effectively applied at ultra-low temperatures.
On accurate measurement of link quality in multi-hop wireless mesh networks (2006)

This paper presents a highly efficient and accurate link-quality measurement framework, called EAR (Efficient and Accurate link-quality monitoR), for multi-hop wireless mesh networks, that has several salient features. First, it exploits three complementary measurement schemes: passive, cooperative, and active monitoring. EAR maximizes the measurement accuracy by (i) dynamically and adaptively adopting one of these schemes and (ii) opportunistically exploiting the nicast application traffic present in the network, while minimizing the measurement overhead. Second, EAR effectively identifies the existence of wireless link asymmetry by measuring the quality of each link in both directions of the link, thus improving the utilization of network capacity by up to 114%. Finally, its reliance on both the network layer and the IEEE 802.11-based device driver solutions makes EAR easily deployable in existing multi-hop wireless mesh networks without system recompilation or MAC firmware modification. EAR has been evaluated extensively via both ns-2-based simulation and experimentation on our Linux-based implementation. Both simulation and experimentation results have shown EAR to provide highly accurate link-quality measurements with minimum overhead.
ChemInform Abstract: Superior Amine Catalysts for the Baylis—Hillman Reaction: The Use of DBU and Its Implications. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Reply to “Improving Microbiology Research: the Problems Are Less Statistical and More Biological” (2016)

Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USAa; Division of Surgery, Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USAb; American Society for Microbiology, Washington, DC, USAc; Pacific Biosciences Research Center, University of Hawaii at Manoa, Honolulu, Hawaii, USAd; University of Washington School of Medicine, Seattle, Washington, USAe
Investigation of breakdown behavior for AlGaN HEMTs (2009)

The ability to accurately determine the breakdown voltage of microwave transistors is critical to the design of high power microwave amplifiers. The optimal bias point and output impedance should be selected to ensure that the load line of the device during peak output power does not intersect the portion of the IV curve where the device breaks down. This paper presents a technique to determine a drain-source breakdown voltage measurement that is useful for the design of high power microwave amplifiers. This measurement has been performed on GaN HEMTs from several different domestic foundries. Using the results of this experiment, an optimal bias point that makes use of the entire load line while at the same time avoiding the destructive effects of breakdown, can be selected.
Ultra-low noise, ultra-stable-power cyan laser (2004)

We describe the performance of a next generation solid-state cyan (488 /spl mu/m) laser. We demonstrate the low noise and high power stability that result from its directly doubled external cavity design.
Phenotypic Characterization of Distinct Human Bone Marrow–Derived MSC Subsets (2009)

Very recently, we identified two distinct mesenchymal stem cell (MSC) subsets in primary bone marrow (BM) that differ in their expression pattern (CD271(bright)MSCA-1(dim)CD56(+) and CD271(bright)MSCA-1(bright)CD56(-)) and morphology as well as in their clonogenic and differentiation capacity. Here we analyzed the cell surface antigen expression in these subsets in more detail and compared the profiles with the expression pattern on cultured MSCs. Most of the tested antigens, including CD13, CD15, CD73, CD140b, CD144, CD146, and CD164, are expressed at similar levels in both primary BM populations. However, a number of markers were differentially expressed. Of these, CD166 (ALCAM), CD200, and CD106 (VCAM-1) showed an almost selective expression on either CD271(bright)MSCA-1(dim)CD56(+) (increased CD166 and CD200 expression) or CD271(bright)MSCA-1(bright)CD56(-) (increased CD106 expression) MSCs, respectively. Additional markers with elevated expression on CD56(+) MSCs include F9-3C2F1, HEK-3D3, HEK5-1B3, and W1C3 antigens, whereas CD10, CD26, CD106, 7C5G1, 9A3G2, 56A1C2, 66E2D11, HEK-3D6, HEK4-1A1, HEK4-2D6, W1D6, W4A5, W7C6, and W8B2 (MSCA-1) antigens showed increased expression in the CD56(-) population. The majority of the analyzed markers found on primary MSCs were also expressed on cultured MSCs. However, in contrast to primary MSCs, HEK7-1C4, W1C3, W1D6, and W4A5 antigens were absent on the cultured counterparts. 7G5G1 and 9A3G2 antigens showed reduced, and HEK-3D6, F9-3C2, and HEK-3D3 showed increased expression on cultured cells. The extended knowledge about the phenotype of the two subsets and the identification of novel MSC markers may result in the isolation of attractive starting populations for applications in regenerative medicine.
Benchmarking and Optimization of Gradient Boosted Decision Tree Algorithms (2018)

Gradient boosting decision trees (GBDTs) have seen widespread adoption in academia, industry and competitive data science due to their state-of-the-art performance in many machine learning tasks. One relative downside to these models is the large number of hyper-parameters that they expose to the end-user. To maximize the predictive power of GBDT models, one must either manually tune the hyper-parameters, or utilize automated techniques such as those based on Bayesian optimization. Both of these approaches are time-consuming since they involve repeatably training the model for different sets of hyper-parameters. A number of software GBDT packages have started to offer GPU acceleration which can help to alleviate this problem. In this paper, we consider three such packages: XGBoost, LightGBM and Catboost. Firstly, we evaluate the performance of the GPU acceleration provided by these packages using large-scale datasets with varying shapes, sparsities and learning tasks. Then, we compare the packages in the context of hyper-parameter optimization, both in terms of how quickly each package converges to a good validation score, and in terms of generalization performance.
Salinity stress adaptation competence in the extremophile Thellungiella halophila in comparison with its relative Arabidopsis thaliana (2005)

In stark contrast to Arabidopsis, a related species, Thellungiella halophila (Thellungiella salsuginea; salt cress), displays extreme tolerance to high salinity, low humidity and freezing. High nucleotide sequence identity permits the use of tools developed for Arabidopsis for Thellungiella transcript profiling, for which a microarray platform with >25,000 DNA elements (70-mer oligonucleotides) was used. Microarray transcript profiling and intensity analysis, quantitative RT-PCR, and metabolite profiles define genes and pathways that showed shared and divergent responses to salinity stress in the two species. Shared responses are exemplified by 40% of the regulated genes functioning in confining ribosomal functions, photosynthesis and cell growth, as well as activating osmolyte production, transport activities and abscisic acid-dependent pathways. An additional 60% of regulated genes distinguished Thellungiella from Arabidopsis. Analysis of the differences showed that Arabidopsis exhibited a global defense strategy that required bulk protein synthesis, while Thellungiella induced genes functioning in protein folding, post-translational modification and protein redistribution. At 150 mm NaCl, Thellungiella maintained unimpeded growth. Transcript intensity analyses and metabolite profiles supported the microarray results, pointing towards a stress-anticipatory preparedness in Thellungiella.
Evaluation of SiC JFET Performance During Repetitive Pulsed Switching Into an Unclamped Inductive Load (2014)

Silicon carbide (SiC) depletion mode junction field-effect transistors (JFETs) are well suited for pulsed power applications as an opening switch due to their normally ON (N-ON) nature. To assess the robustness and breakdown energy tolerance of JFETs under pulsed conditions, they must be evaluated for breakdown energy capability before failure. This is very important for circuit breaker applications due to the large voltage spikes induced during the opening of the circuit breaker while it still conducts substantial load current. These voltage spikes can drive the JFET into the breakdown voltage regime and may result in device failure if the energy dissipation is above the tolerance limit. To determine the maximum avalanche energy of the device under repetitive pulsed conditions, a N-ON SiC JFET with a nominal rating of 1200 V/13 A was driven into punchthrough breakdown using an unclamped inductive switching (UIS) circuit. The testing comprised of 4000 repetitive pulses at 25°C case temperature at a fixed gate voltage of -20 V. The drain current was increased after every 1000 pulses to increase the energy dissipated. The JFET was able to withstand 1000 pulses at a maximum energy dissipation value of 1160 mJ before failure. The JFET triode breakdown characteristics were analyzed after every 1000 pulses. The peak UIS energy of 1160 mJ corresponded to an energy density of 16.6 J/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> based on their active area.
Complexes of iron(II) and iron(III) with the tetradentate macrocycle 5,7,7,12,14,14-hexamethyl-1,4,8,11-tetraazacyclotetradeca-4,11-diene (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComplexes of iron(II) and iron(III) with the tetradentate macrocycle 5,7,7,12,14,14-hexamethyl-1,4,8,11-tetraazacyclotetradeca-4,11-dieneVirgil L. Goedken, Philip H. Merrell, and Daryle H. BuschCite this: J. Am. Chem. Soc. 1972, 94, 10, 3397–3405Publication Date (Print):May 1, 1972Publication History Published online1 May 2002Published inissue 1 May 1972https://pubs.acs.org/doi/10.1021/ja00765a023https://doi.org/10.1021/ja00765a023research-articleACS PublicationsRequest reuse permissionsArticle Views375Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Cubic-Phase Metasurface for Three-Dimensional Optical Manipulation (2021)

The optical tweezer is one of the important techniques for contactless manipulation in biological research to control the motion of tiny objects. For three-dimensional (3D) optical manipulation, shaped light beams have been widely used. Typically, spatial light modulators are used for shaping light fields. However, they suffer from bulky size, narrow operational bandwidth, and limitations of incident polarization states. Here, a cubic-phase dielectric metasurface, composed of GaN circular nanopillars, is designed and fabricated to generate a polarization-independent vertically accelerated two-dimensional (2D) Airy beam in the visible region. The distinctive propagation characteristics of a vertically accelerated 2D Airy beam, including non-diffraction, self-acceleration, and self-healing, are experimentally demonstrated. An optical manipulation system equipped with a cubic-phase metasurface is designed to perform 3D manipulation of microscale particles. Due to the high-intensity gradients and the reciprocal propagation trajectory of Airy beams, particles can be laterally shifted and guided along the axial direction. In addition, the performance of optical trapping is quantitatively evaluated by experimentally measured trapping stiffness. Our metasurface has great potential to shape light for compact systems in the field of physics and biological applications.
An analog neural network solution to the inverse problem of 'early taction' (1992)

The authors examine an application of analog neural networks to low-level processing of tactile sensory data. In analogy to the term early vision, the authors call the first level of processing required in tactile sensing early taction. The problem of deblurring or deconvolution of data provided by an array of tactile sensors that is also assumed to be corrupted by noise is addressed. It is noted that this inverse problem is ill posed and that the technique of regularization may be used to obtain solutions. The theory of nonlinear electrical networks is utilized to describe energy functions for a class of nonlinear networks and to show that the equilibrium states of the proposed network correspond to regularized solutions of the deblurring problem. An entropy regularizer is incorporated into the energy function of the network for the recovery of normal stress distributions. An integrated circuit prototype of the proposed network is discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Distinctions Between CD8+ and CD4+ T-Cell Regenerative Pathways Result in Prolonged T-Cell Subset Imbalance After Intensive Chemotherapy (1997)

Rapid recovery of CD4+ T cells after intensive chemotherapy is limited by an age-dependent decline in thymopoiesis. Here we sought to determine whether similar limitations exist for CD8+ T-cell regeneration. After intensive chemotherapy, CD8+ T cells had a faster effective doubling time than CD4+ T cells (median, 12.6 v 28.2 days, P &lt; .05). Accordingly, at 3 months posttherapy, mean CD8+ T-cell number had returned to baseline, whereas mean CD4+ T-cell number was only 35% of pretherapy values (P &lt; .05). These differences were primarily due to very rapid expansion of CD8+CD57+ and CD8+CD28− subsets. At 3 months posttherapy, there was no relationship between age and CD8+ T-cell number (R = −.02), whereas CD4+ T-cell number was inversely related to age (R = −.66) and there were no discernible differences in CD8+ recovery among patients with or without thymic enlargement, whereas CD4+ recovery was enhanced in patients with thymic enlargement after chemotherapy (P &lt; .01). Therefore thymic-independent pathways of T-cell regeneration appear to rapidly regenerate substantial numbers of CD8+, but not CD4+ T cells, resulting in prolonged T-cell subset imbalance after T-cell depletion. These inherent distinctions between CD4+v CD8+ T-cell regeneration may have significant implications for immunotherapeutic strategies undertaken to eradicate minimal residual neoplastic disease after cytoreductive chemotherapy.