gebhart/patrepeval huggingface dataset:
Immune activation in amniotic fluid from Zika virus–associated microcephaly (2016)

Recent advances in the understanding of neuropathogenesis associated with Zika virus (ZIKV) infection has led to descriptions of neonatal microcephaly cases. However, none of these reports have evaluated the humoral response during ZIKV infection. We report here polyfunctional immune activation associated with increased interferon-gamma-inducible protein 10, interleukin (IL)-6, IL-8, vascular endothelial growth factor (VEGF), monocyte chemoattractive protein 1 (MCP-1), and granulocyte colony-stimulating factor (G-CSF) levels in the amniotic fluid of ZIKV-positive pregnant women with neonatal microcephaly. These cytokines have been associated not only with neuronal damage, but also with differentiation and proliferation of neural progenitor cells. Our results suggested that the immune activation caused by ZIKV infection in the uterine environment could also interfere with fetal development. ANN NEUROL 2017;81:152-156.
Plasma Metabolome Profiling Identifies Metabolic Subtypes of Pancreatic Ductal Adenocarcinoma (2021)

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers. Developing biomarkers for early detection and chemotherapeutic response prediction is crucial to improve the dismal prognosis of PDAC patients. However, molecular cancer signatures based on transcriptome analysis do not reflect intratumoral heterogeneity. To explore a more accurate stratification of PDAC phenotypes in an easily accessible matrix, plasma metabolome analysis using MxP<sup>®</sup> Global Profiling and MxP<sup>®</sup> Lipidomics was performed in 361 PDAC patients. We identified three metabolic PDAC subtypes associated with distinct complex lipid patterns. Subtype 1 was associated with reduced ceramide levels and a strong enrichment of triacylglycerols. Subtype 2 demonstrated increased abundance of ceramides, sphingomyelin and other complex sphingolipids, whereas subtype 3 showed decreased levels of sphingolipid metabolites in plasma. Pathway enrichment analysis revealed that sphingolipid-related pathways differ most among subtypes. Weighted correlation network analysis (WGCNA) implied PDAC subtypes differed in their metabolic programs. Interestingly, a reduced expression among related pathway genes in tumor tissue was associated with the lowest survival rate. However, our metabolic PDAC subtypes did not show any correlation to the described molecular PDAC subtypes. Our findings pave the way for further studies investigating sphingolipids metabolisms in PDAC.
Efficient surface expression of platelet GPIIb-IIIa requires both subunits (1989)

Platelet membrane GPIIb-IIIa is a member of the integrin family of heterodimeric adhesion receptors. Processing and export of certain leukocyte and melanoma integrins is disrupted in cells lacking one subunit. We found that surface expression of GPIIb-IIIa, measured by fluorescent activated cell sorting or by surface labeling, required cotransfection of both subunits. In contrast, surface expression was not detected when the subunits were transfected individually. Immunoprecipitation of metabolically labeled transfected cells confirmed the presence of comparable levels of intracellular protein in all cases. When both subunits were transfected, post-translational cleavage of Pro-GPIIb to yield GPIIb heavy chain was also seen, while transfection with GPIIb alone resulted in coprecipitation of Pro-GPIIb with a second band that may be an endogenous beta subunit. Pro-GPIIb in these transfectants was not processed to yield GPIIb heavy chain. When transfected into COS cells alone, transiently expressed GPIIIa remained intracellular and did not appear to complex with any endogenous proteins. Thus, surface expression of processed GPIIb-IIIa depends on the presence of both subunits; the coordinate reduction of both subunits observed in some cases of Glanzmann's thrombasthenia may result from mutation affecting only one.
Atomistic simulation of doping by adatoms in monolayer MoS2 (2013)

Using an ab initio density functional theory (DFT) based electronic structure method, we study the effects of adatoms on the electronic properties of monolayer transition metal dichalcogenide (TMD) Molybdenum-disulfide (MoS2). We consider the 1st (Li, Na, K) and 7th (F, Cl, Br) column atoms and metals (Sc, Ti, Ta, Mo, Pd, Pt, Ag, Au). Three high symmetry sites for the adatom on the surface of monolayer MoS2 are examined as starting points to search for the most energetically stable configuration for each adatom-monolayer MoS2 system, as well as the type of associated bonding. For the most stable adatom positions, we characterize the emergence of adatom-induced electronic states including any dopant states.
Dermis Fat Graft in Eviscerated Sockets (1989)

Following evisceration, three patients who experienced extrusion of synthetic orbital implant underwent socket reconstruction using an autogenous dermis fat graft. An incision into the fundus of the existing sclera was necessary to provide for an adequate vascular bed for a composite fat graft, although the anterior ring of existing sclera with extraocular muscle attachments was not disturbed. Conjunctival reepithelialization of the dermal surface and enhancement of orbital volume occurred in each case. Furthermore, the autogenous fat graft retained the original excellent globe motility that was present before the socket reconstruction. After an average follow-up of 18 months, the volume restoration, integrity of conjunctival epithelium and fornices, and the graft viability have remained unchanged. As with alloplastic orbital implant extrusions in enucleated sockets, autogeneous dermis fat grafts can be useful in managing extrusions in previously eviscerated sockets.
TrI4: The role of grain boundaries in conduction and breakdown of perovskite-type titanates (1992)

Abstract Based on the defect chemistry of acceptor-doped strontium titanate model materials, the role of interfaces in conduction and voltage-induced failure mechanisms is discussed. The impedance behaviour of conventional ceramics and ceramic thin films is compared.
Bipolaron mechanism for bias-stress effects in polymer transistors (2003)

The slow formation of hole bipolarons is proposed to explain the bias-stress effect that is observed in some polymer thin-film transistors (TFT). The primary evidence is the observation that holes are removed from the channel at a rate proportional to the square of their concentration. As bound hole pairs form, they deplete the TFT channel of mobile holes, which reduces the TFT current and causes a threshold voltage shift. The slow rate of bipolaron formation is attributed to the mutual Coulomb repulsion of the holes. Contrasting stress effects in different polymers are related to the magnitude of the bipolaron binding energy. Present experiments cannot distinguish whether the bipolarons are intrinsic, or associated with disorder, interfaces, or impurities.
Sequential Load-Pull Technique for Multioctave Design of RF Power Amplifiers (2016)

A design methodology for multioctave RF power amplifiers (PAs) is presented in this brief using sequential harmonic characterization. The investigation of in-band harmonics on the multioctave performance of the RF PA shows that a more optimal performance can be achieved using the proposed technique compared to the conventional load-pull. To demonstrate the capability of this technique, a broadband multioctave PA prototype was designed and fabricated using sequential second harmonic characterization. The fabricated prototype uses a GaN HEMT from Cree Inc. and exhibits a drain efficiency of 53%-64% in the range of 0.7-4.0 GHz while having an output power of 37.5-39.1 dBm corresponding to the fractional bandwidth of 140%. Measurement results validate the proposed method as a robust PA design procedure for broadband and multistandard applications.
Detection performance of two-sensor distributed systems for normal local ROCs (1987)

The global performance of two-sensor fusion and serial distributed detection networks are examined. The performance of the local sensors are characterized by normal receiver operating characteristics (ROCs). The networks are compared for different sensor energy distributions at different system energy levels.
Dynamically adaptable NoC router architecture for multiple pixel streams applications (2012)

Modern computing systems for vision have to support advanced image applications. They involve several heterogeneous pixel streams and they have to respect hard timing and area constraints. To face those challenges, an adaptable ring-based interconnection network-on-chip (NoC) has been recently proposed. This NoC is based on a new router architecture, with a dynamically adaptable internal datapath, which allows handling of multiple parallel pixel streams. An original datapath adaptation control is proposed by combining instructions and pixel data to be processed in a single packet. Timing performance and area occupation are evaluated on an FPGA prototype.
High energy superstable hybrid capacitor with a self‐regulated Zn/electrolyte interface and 3D graphene‐like carbon cathode (2022)

Abstract Rechargeable aqueous zinc ion hybrid capacitors (ZIHCs), as an up‐and‐comer aqueous electrochemical energy storage system, endure in their infancy because of the substandard reversibility of Zn anodes, structural deterioration of cathode materials, and narrow electrochemical stability window. Herein, a scalable approach is described that addresses Zn‐anode/electrolyte interface and cathode materials associated deficiencies and boosts the electrochemical properties of ZIHCs. The Zn‐anode/electrolyte interface is self‐regulated by alteration of the traditional Zn 2+ electrolyte with Na‐based supporting salt without surrendering the cost, safety, and green features of the Zn‐based system which further validates the excellent reversibility over 1100 h with suppressed hydrogen evolution. The deficits of cathode materials were overcome by using a high‐mass loaded, oxygen‐rich, 3D, multiscaled graphene‐like carbon (3D MGC) cathode. Due to the multiscaled texture, high electronic conductivity, and oxygen‐rich functional groups of 3D MGC, reversible redox capacitance was obtained with a traditional adsorption/desorption mechanism. Prototype ZIHCs containing the modified electrolyte and an oxygen‐rich 3D MGC cathode resulted in battery‐like specific energy (203 Wh kg −1 at 1.6 A g −1 ) and supercapacitor‐type power capability (4.9 kW kg −1 at 8 A g −1 ) with outstanding cycling durability (96.75% retention over 30 000 cycles at 10 A g −1 ). These findings pave the way toward the utilization of highly efficient ZIHCs for practical applications. image
High-Voltage 4H-Sic PiN Rectifiers with Single-Implant, Multi-Zone JTE Termination (2004)

A novel multi-zone junction termination extension (MZJTE) is presented for high-voltage 4H-SiC pin junction rectifiers. Unlike the conventional multi-implantation or SiC etching approaches, our new termination technique utilizes multiple masking oxide etching steps to achieve a single-implant MZJTE structure that maintains surface planarity. Numerical device simulations have been performed to examine the process sensitivities, compared to single-zone JTE, and yielded breakdown voltages close to 90% of the ideal parallel-plane breakdown voltage. High voltage (V BR ≃8kV) rectifiers were fabricated and experimental characteristics have been measured.
Metal Ion-dependent Heavy Chain Transfer Activity of TSG-6 Mediates Assembly of the Cumulus-Oocyte Matrix (2015)

The matrix polysaccharide hyaluronan (HA) has a critical role in the expansion of the cumulus cell-oocyte complex (COC), a process that is necessary for ovulation and fertilization in most mammals. Hyaluronan is organized into a cross-linked network by the cooperative action of three proteins, inter-α-inhibitor (IαI), pentraxin-3, and TNF-stimulated gene-6 (TSG-6), driving the expansion of the COC and providing the cumulus matrix with its required viscoelastic properties. Although it is known that matrix stabilization involves the TSG-6-mediated transfer of IαI heavy chains (HCs) onto hyaluronan (to form covalent HC·HA complexes that are cross-linked by pentraxin-3) and that this occurs via the formation of covalent HC·TSG-6 intermediates, the underlying molecular mechanisms are not well understood. Here, we have determined the tertiary structure of the CUB module from human TSG-6, identifying a calcium ion-binding site and chelating glutamic acid residue that mediate the formation of HC·TSG-6. This occurs via an initial metal ion-dependent, non-covalent, interaction between TSG-6 and HCs that also requires the presence of an HC-associated magnesium ion. In addition, we have found that the well characterized hyaluronan-binding site in the TSG-6 Link module is not used for recognition during transfer of HCs onto HA. Analysis of TSG-6 mutants (with impaired transferase and/or hyaluronan-binding functions) revealed that although the TSG-6-mediated formation of HC·HA complexes is essential for the expansion of mouse COCs in vitro, the hyaluronan-binding function of TSG-6 does not play a major role in the stabilization of the murine cumulus matrix.
Measurement of Force and Displacement for the Tribological Analysis of MEMS (2005)

The tribological interfaces in microelectromechanical systems (MEMS) pose a significant hurdle in the advancement of MEMS. In order to gain a better understanding of these tribological interfaces, meaningful friction and wear measurements of MEMS devices must be made at loads and speeds relevant to MEMS operation. Devices containing isolated tribological contacts from which quantitative friction forces can be extracted have been developed. Since independent in-plane measurement of forces are not available for structures that are on the order of microns thick, the normal and tangential forces between structures are typically estimated based on the calculation of the force output of electrostatic actuators, and the force required to bend compliant suspensions. We will discuss the uncertainties associated with the measurement of applied and friction forces in MEMS tribometers, and metrology needs for improved tribological analysis of dynamic microsystems. We will also present a method of independent force calibration in these devices, and compare measured output characteristics with those predicted from mechanics and electrostatics.
DISCO (1994)

The natural language system DISCO is described. It combines• a powerful and flexible grammar development system;• linguistic competence for German including morphology, syntax and semantics;• new methods for linguistic performance modeling on the basis of high-level competence grammars;• new methods for modelling multi-agent dialogue competence;• an interesting sample application for appointment scheduling and calendar management.
Liquid-bridging in particle self-assemblies toward constructing periodic nano-mesh structures and nano-dot arrays (2013)

We demonstrate a simple generic principle of constructing periodic nano-mesh structures and nano-dot arrays by liquid-bridging in particle self-assemblies. A self-assembly of nano- to micro-sized spheres of polystyrene, produced in a close-packed monolayer on a substrate by a convective method, is used as a template for liquid-bridging of a functional fluid in the pores among the neighboring particles. After the solidification of the fluid, followed by the detachment of the particles from the substrate, a periodic mesh structure is directly obtained. Moreover, deposition of a desired substance onto such mesh structure made of a sacrificial material, which is subsequently removable through a lift-off process, enables to produce a periodic dot array of the substance. Depending on the size of the particle and the nature of liquid bridging in the particle assembly, a variety of nano-mesh structures of silver-ink and nano-dot arrays of gold are constructed. This simple liquid bridging-based methodology is easily applicable for different classes of functional fluids such as soluble organic semiconductors.
Temporal event clustering for digital photo collections (2003)

We present similarity-based methods to cluster digital photos by time and image content. The approach is general, unsupervised, and makes minimal assumptions regarding the structure or statistics of the photo collection. We present results for the algorithm based solely on temporal similarity, and jointly on temporal and content-based similarity. We also describe a supervised algorithm based on learning vector quantization. Finally, we include experimental results for the proposed algorithms and several competing approaches on two test collections.
The contribution of protease-activated receptor 1 to neuronal damage caused by transient focal cerebral ischemia (2003)

The serine proteases tissue plasminogen activator, plasmin, and thrombin and their receptors have previously been suggested to contribute to neuronal damage in certain pathological situations. Here we demonstrate that mice lacking protease-activated receptor 1 (PAR1) have a 3.1-fold reduction in infarct volume after transient focal cerebral ischemia. Intracerebroventricular injection of PAR1 antagonist BMS-200261 reduced infarct volume 2.7-fold. There are no detectable differences between PAR1-/- and WT mice in cerebrovascular anatomy, capillary density, or capillary diameter, demonstrating that the neuroprotective phenotype is not likely related to congenital abnormalities in vascular development. We also show that the exogenously applied serine proteases thrombin, plasmin, and tissue plasminogen activator can activate PAR1 signaling in brain tissue. These data together suggest that if blood-derived serine proteases that enter brain tissue in ischemic situations can activate PAR1, this sequence of events may contribute to the harmful effects observed. Furthermore, PAR1 immunoreactivity is present in human brain, suggesting that inhibition of PAR1 may provide a novel potential therapeutic strategy for decreasing neuronal damage associated with ischemia and blood-brain barrier breakdown.
MIME Type Registrations for JPEG 2000 (ISO/IEC 15444) (2004)

This document serves to register and document the standard MIME types associated with the ISO/IEC 15444 standards, commonly known as JPEG 2000 (Joint Photographic Experts Group).
Transparent gathering of provenance during program execution (2010)

Many computer programs consume and produce a large amount of data. In order to better understand the program output, the user often desires to know the details about how the output was created. Data provenance, the origin and history of data, can be used to learn about the creation of a program output. The focus of this dissertation is collecting provenance during the execution of a program. In the first part of this dissertation I explore provenance in the context of a distributed job execution system. I identify the types of provenance that can be gathered from a job run in such a system. In the second part, I present a system that gathers provenance from programs run in a distributed job execution system. The provenance system developed in the second part of this dissertation does a good job at gathering information about the system resources used by a program, but it lacks the ability to answer questions that involve the semantics of the program. This result motivates the third part of the dissertation where I examine provenance in the context of an information extraction program. Writing the information extraction program in a logic programming language exposes the semantics of the program, allowing the provenance system to gather detailed information about the flow of data through the program. This enables the provenance system to provide detailed answers to questions about how the output data was created. In the fourth part of this dissertation I take the systems that were built in the second and third parts of the dissertation, and conduct a case study of gathering provenance from the DBLife information extraction and integration program.
Mono‐benzyl Substituted cis,cis‐1,3,5‐Triaminocyclohexanes. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Fluorine-18 labeled insulin: a prosthetic group methodology for incorporation of a positron emitter into peptides and proteins (1989)

In the present study we synthesize 18F-labeled insulin of high specific radioactivity. A new prosthetic group methodology, in which [18F]fluoride displaces a bromide group of 4-(bromomethyl)-benzoylamine intermediates, was used. The 4-(fluoromethyl)benzoyl product was chemically stable. 18F-Labeled insulin retains the essential biological properties of native insulin, as measured in vitro by binding to insulin receptors on human cells and stimulation of glucose metabolism in rat adipocytes. The overall process can be carried out speedily to yield a product of sufficient purity to permit in vivo studies. The method appears to be applicable to a wide variety of peptides.
Light-Assisted Diazonium Functionalization of Graphene and Spatial Heterogeneities in Reactivity (2019)

The reaction of monolayer graphene with aryl diazonium salts is a popular approach for functionalizing graphene under ambient conditions. We here apply interference reflection microscopy (IRM), a label-free optical technique, to study the in situ reaction dynamics of the representative diazonium reaction of graphene with 4-nitrobenzenediazonium tetrafluoroborate (4-NBD) at high spatiotemporal resolution and further correlate results with atomic force microscopy, Raman spectroscopy, and infrared scattering scanning near-field optical microscopy. Interestingly, we find the reaction to be significantly promoted by a low (0.5 W/cm<sup>2</sup>) level of blue visible light, whereas at the same intensity level, red light has negligible effects on reaction rate. We further report rich spatial heterogeneities for the reaction, including enhanced reactivity at graphene edges and an unexpected flake-to-flake variation in reaction rate. Moreover, we demonstrate direct photopatterning for the 4-NBD functionalization, achieving 400 nm patterning resolution.
Spontaneous release of acetylcholine from autonomic nerves in the bladder (2009)

The data indicate that there is spontaneous TTX-resistant release of acetylcholine from autonomic cholinergic extrinsic and intrinsic nerves, which significantly affects bladder contractility. This release is resistant to blockade of N, P/Q and R type Ca(2+) channels.