gebhart/patrepeval huggingface dataset:
Acanthocytosis associated with myelodysplasia. (1989)

Dysplastic hematopoiesis associated with erythrocyte macrocytosis is a morphologic hallmark of myelodysplasia. We report the cases of six patients with myelodysplasia in which acanthocytosis was the predominant red blood cell (RBC) abnormality. In each case acanthocytes represented 5% to 10% of circulating RBC forms and was the primary reason for referral in two cases. None of the patients had comorbid conditions known to be associated with acanthocyte formation. Myelodysplasia should be considered in the differential diagnosis of acanthocytosis, particularly in the anemic, elderly individual. Acanthocytosis may be a harbinger of an unrecognized, hematologic stem-cell disorder.
A compact model for the zigzag triboelectric nanogenerator energy harvester (2020)

Energy is a global demand nowadays. Researchers and Scientists are trying every day to find new resources to generate energy. Mechanical energy is considered one of the most essential energy resources in the world. It can be easily generated and transferred into electrical energy. There are a lot of new technologies that are working to develop small and portable energy harvesters for electronic devices such as piezoelectric and triboelectric nanogenerators (TENGs). However, TENGs are more favorable to piezoelectric nanogenerators due to the availability of nontoxic materials. Moreover, they are cheap and exhibit high performance. This article investigates one of the TENG devices, Zigzag structure. It presents an analytical derivation for the model that addresses all aspects of the TENG such as the output voltage, the output current, the capacitance, the resistive load, the capacitive load and the harvested power step by step. The analytical derivation is also verified using COMSOL simulations to validate the results. The mismatch between the analytical derivation and COMSOL is 0.022% in the open circuit voltage and 0.33% in short circuit charge. Electrical behavior is presented afterwards using Verilog-A in Cadence to examine the performance of the TENG devices in real life situations. For the chosen parameters, the device delivers a maximum voltage of 23 KV at nearly 90° and a maximum current of 7.5 μA at nearly 10°. The maximum reported output power for a load of 5 GΩ is 5.2 mW.
Spontaneous subarachnoid hemorrhage of unknown origin: hospital course and long-term clinical and angiographic follow-up (2014)

Hydrocephalus and delayed cerebral ischemia, while infrequent, do occur in SAH of unknown origin. Long-term neurological outcomes are generally good. A thorough evaluation to rule out an etiology of hemorrhage is necessary; however, imaging beyond 6 weeks from ictus has little utility, and rebleeding is unexpected.
Fast Decoding ECC for Future Memories (2016)

High-performance storage class memories could benefit from a fast decoding error correcting code (ECC), able to correct a few errors in just a few nanoseconds. The class of BCH codes provides excellent candidates to play this role. The low latency requirement prevents adopting iterative or sequential processes in the encoding and decoding phases-as traditionally done for storage application based on Flash NAND technology. Therefore, we propose an architecture for fast decoding of double and triple ECCs. In our architecture, any time-consuming iterative computation is eliminated, and the most complex evaluations are isolated and carried in parallel with the other terms, to avoid bottlenecks in the decoder. In particular, the error locator polynomial is computed by a combinatorial logic, and its roots are searched by testing all the bits simultaneously. Here, we describe a gate-level design of these architectures. We also give an in-depth analysis of hardware-oriented implementations of finite field operations, and of bases for element representation.
Are Managers the new barbarians destroying local and national societies (2014)

First lines: Amused by his former students at the London Business School, Ian Angell wrote the The New Barbarian Manifesto in the early 2000s, identifying an emerging class of transnational mobile rational actors taking advantage of collective goods and services in the places where they lived. They did not invest resources or commit themselves to local places, going private and temporary for as many services as possible. Angell encouraged them to free-ride, make money, and organize their interests at a global scale, undermining existing social structures, States, taxation systems, and old national elites.
A Phenomenological Numerical Model For Fused Deposition Processing of Particle Filled Parts (2018)

Fused Deposition ModelingTM utilizes the simple idea of melting, extrusion and&#13;\nresolidification of thermoplastic filaments. The introduction of particulate materials,&#13;\nespecially ceramics and metals, will widen the range of capabilities of the process. The&#13;\npresent study is directed to the development of a family of numerical models for the&#13;\nFDM and Fused Deposition of Ceramics processes. These models in turn would help to&#13;\npredict the operation windows of the FDM/FDC. Time-dependent mesh generation and&#13;\nparameter file generation are incorporated into the developed two-dimensional model.&#13;\nFinite element method is used in order to address heat transfer issues regarding the&#13;\nsolidification ofthe thermoplastic binder
Alkylated Porphyrins Have Broad Antiviral Activity against Hepadnaviruses, Flaviviruses, Filoviruses, and Arenaviruses (2010)

We screened ∼2,200 compounds known to be safe in people for the ability to reduce the amount of virion-associated hepatitis B virus (HBV) DNA in the culture medium of producer cells. These efforts led to the discovery of an alkylated porphyrin, chlorophyllide, as the compound that achieved the greatest reduction in signal. Here we report that chlorophyllide directly and quantitatively disrupted HBV virions at micromolar concentrations, resulting in the loss of all detectable virion DNA, without detectably affecting cell viability or intracellular viral gene products. Chemophores of chlorophyllide were also tested. Chlorin e6, a metal-free chlorophyllide-like molecule, showed the strongest antiviral activity against HBV as well as profound antiviral effects on other enveloped viruses, such as hepatitis C virus (HCV), human immunodeficiency virus (HIV), dengue virus (DENV), Marburg virus (MARV), Tacaribe virus (TCRV), and Junin viruses (JUNV). Remarkably, chlorin e6 inactivated DENV at subnanomolar-level concentrations. However, the compound had no antiviral effect against encephalomyocarditis virus and adenovirus, suggesting that chlorin e6 may be less active or inactive against nonenveloped viruses. Although other porphyrin derivatives have been previously reported to possess antiviral activity, this is the first analysis of the biochemical impact of chlorophyllide and chlorin e6 against HBV and of the dramatic anti-infectivity impact upon DENV. The possible application of this family of compounds as antiviral agents, as microbicides and systemic virus neutralizing agents, is discussed.
Simultane Erfassung von 3D-Form und Farbe komplexer Objekte (Simultaneous Measurement of Shape and Color of Complex Objects) (2003)

Abstract Methoden zum Erfassen der 3D-Form von Objekten sind seit vielen Jahren bekannt. In verschiedenen Anwendungen ist es jedoch notwendig, die Objektform und -farbe komplex geformter Objekte vollständig zu erfassen. Die Verwendung von Farbkameras hat den Nachteil niedriger Auflösung, niedriger Bildraten und kann Formmessfehler verursachen. Die hier vorgestellte Messmethode ermöglicht die simultane Erfassung von Form und Farbe unter ausschließlicher Verwendung von Monochromkameras.
Alteration of the Biochemical Valves in the Central Metabolism of Escherichia colia (1994)

Although E. coli central metabolism has been studied for several decades, many regulatory features are still unknown. To achieve the goal of rational manipulation of cellular metabolism, it is important to understand how E. coli responds to overexpressed enzymes. By studying the biochemical control of fluxes between PEP, pyruvate, and OAA, we have addressed some fundamental questions that may prove to be essential for applications in metabolic engineering. First, we found that simultaneous overexpression of Pck and Ppc, or Pps alone in the presence of glucose leads to phenotypes consistent with futile cycline. In contrast to our expectation, futile cycling per se does not affect the growth rate significantly. However, excessive futile cycling may cause competitive disadvantage in the natural environment. Overexpression of Pck caused growth inhibition but no futile cycling. Therefore, E. coli controls the expression of gluconeogenic enzymes not only to avoid excessive futile cycling, but also to prevent toxicity effects. In metabolic engineering, futile cycling may be used as a strategy to stimulate metabolism for either production of metabolites or digestion of toxic wastes. Second, we found that the expression levels of Pps and Pck in E. coli are not optimal for growth on pyruvate and succinate, respectively. Overexpression of these enzymes increases the growth rate on pyruvate and on succinate, respectively, indicating that the slow growth rates on these substrates are at least partially caused by the insufficient supply of PEP and its derivatives. Moreover, E. coli also has not optimized the Ppc level for optimal growth yield on glucose in uncontrolled batch cultures. These results demonstrate that the central metabolism is not optimized for growth under defined laboratory conditions. Thus, the possibility exists that adjustment of native enzyme levels in the central metabolism can improve bioreactor performance. Third, we found that overexpression of Pck affects the transcriptional levels of unrelated genes. This example indicates that physiological responses to enzyme (over)expression should be interpreted cautiously, as changing the expression level of a specific enzyme may affect many unlinked genes. Similar results have also been obtained by use of two-dimensional electrophoresis of proteins from E. coli. Although more questions remain to be answered, fast progress in the area of metabolic engineering can be expected in the near future.
Deep learning detector for high precision monitoring of cell encapsulation statistics in microfluidic droplets (2022)

Encapsulation of cells inside microfluidic droplets is central to several applications involving cellular analysis. Although, theoretically the encapsulation statistics are expected to follow a Poisson distribution, experimentally this may not be achieved due to lack of full control of the experimental variables and conditions. Therefore, there is a need for automatic detection of droplets and cell count enumeration within droplets so a process control feedback to adjust experimental conditions can be implemented. In this study, we use a deep learning object detector called You Only Look Once (YOLO), an influential class of object detectors with several benefits over traditional methods. This paper investigates the application of both YOLOv3 and YOLOv5 object detectors in the development of an automated droplet and cell detector. Experimental data was obtained from a microfluidic flow focusing device with a dispersed phase of cancer cells. The microfluidic device contained an expansion chamber downstream of the droplet generator, allowing for visualization and recording of cell-encapsulated droplet images. In the procedure, a droplet bounding box is predicted, then cropped from the original image for the individual cells to be detected through a separate model for further examination. The system includes a production set for additional performance analysis with Poisson statistics while providing an experimental workflow with both droplet and cell models. The training set is collected and preprocessed before labeling and applying image augmentations, allowing for a generalizable object detector. Precision and recall were utilized as a validation and test set metric, resulting in a high mean average precision (mAP) metric for an accurate droplet detector. To examine model limitations, the predictions were compared to ground truth labels, illustrating that the YOLO predictions closely matched with the droplet and cell labels. Furthermore, it is demonstrated that droplet enumeration from the YOLOv5 model is consistent with hand counted ratios and the Poisson distribution, confirming that the platform can be used in real-time experiments for cell encapsulation optimization.
Avoiding Breast Animation Deformity with Pectoralis-Sparing Subcutaneous Direct-to-Implant Breast Reconstruction (2016)

There is renewed interest in sparing the pectoralis major muscle in implant breast reconstruction, placing the implant in the subcutaneous position. This advance is made reliable by improvements in mastectomy skin flap quality, evolution of technique, and increased awareness of breast animation deformity. This retrospective review presents 13 patients (23 breasts) reconstructed immediately with placing the definitive implant in the subcutaneous space without disruption of the underlying chest muscles. None of the 13 patients had breast animation deformity postoperatively. One patient experienced an early hematoma, and 3 patients had small seromas that resolved uneventfully. One morbidly obese patient undergoing chemotherapy using a nearby chest port experienced infection requiring implant removal. This study describes an early experience, demonstrates feasibility, and discusses patient selection considerations that are important because we continue to evolve breast reconstruction approaches.
Beam Selection and Tracking for Amplify-and-Forward Repeaters (2022)

Mobile network operators constantly have to upgrade their cellular network to satisfy the public’s hunger for increasing data capacity. However, regulatory limits regarding allowed electromagnetic field strength on existing cell sites often limit or prevent the installation of new cells on additional frequency bands. Further densifying the radio access infrastructure by means of new cell sites takes time because of the site acquisition, the need for permissions, and the civil construction. To this end, amplify-and-forward repeaters are a cost-efficient method to provide mobile wireless data capacity to concealed areas outdoors, inside buildings, or vehicles, where low signal levels drastically limit the achievable capacity or even prevent communication with distant base stations. Repeaters with high-gain beamforming antennas can be used to decrease the path loss and thereby offer a higher capacity than user equipment otherwise could achieve. Since those highly directional beams must be constantly adjusted, we propose methods to align and track the beam even without having access to in-band beam control mechanisms. Numerical analyses with measurement data show that such non-invasive (system data-agnostic) methods are feasible and only incur a few percent in throughput reduction.
High-throughput broadband Fourier-transform CARS (2016)

We propose and demonstrate a technique for Fourier-transform CARS spectroscopy that performs broadband CARS measurements at a record high throughput of 24,000 spectra/s for diverse high-speed chemical analysis applications.
Chimeric receptor analyses of the interactions of the ectodomains of ErbB‐1 with epidermal growth factor and of those of ErbB‐4 with neuregulin (2002)

A series of chimeric receptors was generated between the epidermal growth factor (EGF) receptor, ErbB-1, and its homologue, ErbB-4, to investigate the roles of the extracellular domains (I-IV) in the ligand specificities. As compared with ErbB-1 and the chimeras with both domains I and III of ErbB-1, the chimeras with only one of these domains exhibited reduced binding of 125I-labeled EGF. Particularly, the contribution of domain III was appreciably larger than that of domain I of ErbB-1 in 125I-labeled EGF binding. Nevertheless, the chimeras with domain III of ErbB-1 and domain I of ErbB-4 were prevented from binding to 125I-labeled EGF competitively by the ErbB-4 ligand, neuregulin (NRG). On the other hand, NRG did not compete with 125I-labeled EGF for binding to the chimeras with the ErbB-1 domain I and the ErbB-4 domain III. Therefore, NRG binding to ErbB-4 depends much more on domain I than on domain III. With respect to autophosphorylation and subsequent ERK activation, EGF activated the chimeras with either domain I or III of ErbB-1. In contrast, NRG activated the chimeras with the ErbB-4 domain I and the ErbB-1 domain III, but not those with the ErbB-1 domain I and the ErbB-4 domain III. Therefore, the relative contributions between domains I and III of ErbB-4 in the NRG signaling are different from those of ErbB-1 in the EGF signaling.
Investigation of Bending/Buckling Characteristics for FRP Composite Poles (2006)

In recent years, the application of high-performance FRP composites in construction industry has grown tremendously in several different directions. The composite materials have been used extensively in manufacturing stand-alone structural members such as beams, columns, and wall panels in cooling tower system, in strengthening and retrofitting the existing but deteriorating structures to prevent the corrosion of steel members and the spalling of concrete surface. Other application area under consideration include infrastructure and facility members for transmission towers, closed circuit television poles, sign posts, guardrails, bridge railings, and light-gage structural system. The primary purpose of this paper is to investigate an application of FRP composites in product development for utility and/or lighting fixture poles, highway sign post, and medium size of transmission tower elements. This kind of infrastructural system can be designed, constructed, and operated in many challenging environments on planet earth, in-space, and on other planetary bodies such as the moon and mars. The objectives of this investigation are: (a) to determine the bending and buckling strengths of various FRP poles using eigenvalue solution, (b) to evaluate and compare the ultimate strength and stress of the facility poles using three dimensions finite element computational analysis, and (c) to perform the parametric structural efficiency analysis for determining an optimum rigidity length ratio, a/l, between the variable length from the fixed end to the overall length of the pole. The results indicate that the rigidity length ratio, a/l, as well as the moment of inertia ratio, IT / IB, have significant influence on the performance of facility poles, The study also proves that the step pole used in analytical model is light weight than the convention tapered pole for particular configurations.
Results from Phase I Clinical Trial with Intraspinal Injection of Neural Stem Cells in Amyotrophic Lateral Sclerosis: A Long-Term Outcome (2019)

The main objective of this phase I trial was to assess the feasibility and safety of microtransplanting human neural stem cell (hNSC) lines into the spinal cord of patients with amyotrophic lateral sclerosis (ALS). Eighteen patients with a definite diagnosis of ALS received microinjections of hNSCs into the gray matter tracts of the lumbar or cervical spinal cord. Patients were monitored before and after transplantation by clinical, psychological, neuroradiological, and neurophysiological assessment. For up to 60 months after surgery, none of the patients manifested severe adverse effects or increased disease progression because of the treatment. Eleven patients died, and two underwent tracheotomy as a result of the natural history of the disease. We detected a transitory decrease in progression of ALS Functional Rating Scale Revised, starting within the first month after surgery and up to 4 months after transplantation. Our results show that transplantation of hNSC is a safe procedure that causes no major deleterious effects over the short or long term. This study is the first example of medical transplantation of a highly standardized cell drug product, which can be reproducibly and stably expanded ex vivo, comprising hNSC that are not immortalized, and are derived from the forebrain of the same two donors throughout this entire study as well as across future trials. Our experimental design provides benefits in terms of enhancing both intra- and interstudy reproducibility and homogeneity. Given the potential therapeutic effects of the hNSCs, our observations support undertaking future phase II clinical studies in which increased cell dosages are studied in larger cohorts of patients. Stem Cells Translational Medicine 2019;8:887&897.
Alternating Radical Stabilities: A Convergent Route to Terminal and Internal Boronates (2019)

Pinacolato boronates (Bpin) with an empty p-orbital on boron stabilize an adjacent carbon radical, in contrast to diethanolamino boronates [B(DEA)] where the boron is sp<sup>3</sup> -hybridized. By alternately placing a pinacol or diethanolamine moiety on the boron atom, thus stabilizing or not stabilizing the corresponding adjacent radical, it is possible to control the behavior of α-boronyl xanthates and construct a large variety of terminal or internal boronates in a modular fashion. The remarkable tolerance of polar groups and the ability to introduce quaternary centers are particularly noteworthy features of this process.
Fast-light Enhanced Brillouin Laser Based Active Fiber Optics Sensor for Simultaneous Measurement of Rotation and Acceleration (2016)

We show an enhancement of ~358 for two counter-propagating Brillouin lasers in the sensitivity of an Active Fast Light Fiber Optic Sensor, which performs as a gyroscope and a sensor for acceleration, strain and temperature.
A Charge Based Compact Modeling Technique for Monocrystalline TFTs on Glass (2010)

A thin-film monocrystalline CMOS display technology has been realized by implementing a conventional NMOS inversion device and a PMOS accumulation device. In this paper, a charge based modeling technique is introduced which provides the dc current-voltage characteristics for both inversion and accumulation devices. Since conduction occurs at the surface and in the bulk of accumulation devices, traditional charge sheet models are invalid. Starting directly from the Pao-Sah equation by applying the 1-D Gauss' Law, C-∞ expressions able to capture the effect of both surface and bulk conduction suitable for circuit simulations are derived. The model is validated against the two-dimensional device simulation.
ChemInform Abstract: Synthesis of Monophasic CaxBa(1‐x)TiO3 Nanoparticles with High Ca Content (x < 23%) and Their Photoluminescence Properties. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.