gebhart/patrepeval huggingface dataset:
Data from Phase I Trial of N-803, an IL15 Receptor Agonist, with Rituximab in Patients with Indolent Non-Hodgkin Lymphoma (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;N-803 is an IL15 receptor superagonist complex, designed to optimize &lt;i&gt;in vivo&lt;/i&gt; persistence and trans-presentation, thereby activating and expanding natural killer (NK) cells and CD8&lt;sup&gt;+&lt;/sup&gt; T cells. Monoclonal antibodies (mAbs) direct Fc receptor–bearing immune cells, including NK cells, to recognize and eliminate cancer targets. The ability of IL15R agonists to enhance tumor-targeting mAbs in patients has not been reported previously.&lt;/p&gt;Patients and Methods:&lt;p&gt;Relapsed/refractory patients with indolent non-Hodgkin lymphoma were treated with rituximab and intravenous or subcutaneous N-803 on an open-label, dose-escalation phase I study using a 3+3 design (NCT02384954). Primary endpoint was maximum tolerated dose. Immune correlates were performed using multidimensional analysis via mass cytometry and cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq) which simultaneously measures protein and single-cell RNA expression.&lt;/p&gt;Results:&lt;p&gt;This immunotherapy combination was safe and well tolerated and resulted in durable clinical responses including in rituximab-refractory patients. Subcutaneous N-803 plus rituximab induced sustained proliferation, expansion, and activation of peripheral blood NK cells and CD8 T cells, with increased NK cell and T cells present 8 weeks following last N-803 treatment. CITE-seq revealed a therapy-altered NK cell molecular program, including enhancement of AP-1 transcription factor. Furthermore, the monocyte transcriptional program was remodeled with enhanced MHC expression and antigen-presentation genes.&lt;/p&gt;Conclusions:&lt;p&gt;N-803 combines with mAbs to enhance tumor targeting in patients, and warrants further investigation in combination with immunotherapies.&lt;/p&gt;&lt;/div&gt;
Proactive crossover router discovery with FMIPv6 (2006)

This paper presents an enhanced fast handover scheme in Mobile IPv6 named Cross based Fast handover Mobile IPv6 (X-FMIPv6). We propose Proactive Crossover Router Discovery scheme that allow us to locate Crossover Router in advance, before MN actually makes handover. Enhanced fast handover scheme based on FMIPv6 is proposed with tunnel establishment between Crossover Router and new Access Router to achieve the optimum routing and minimize network resource usage. The simulation of FMIPv6 and X-FMIPv6 is performed and the simulation results show that our proposed scheme give better performance compared with FMIPv6 in term of handover latency, transmission delay and number of out-of-order packets.
Shared Angles-of-Departure in Massive MIMO Channels: Correlation Analysis and Performance Impact. (2020)

In practical environments, recent massive MIMO measurements demonstrate that user channels can be correlated. In this paper, we study the user channel correlation induced by shared angles-of-departure. We first derive the user correlation distribution in the large array regime, and then examine the user correlation using actual measurements from a large array. As a data-driven observation, we discover that the correlation of all close-by users is higher than $0.4$ and barely reduces as the number of base-station antennas $M$ increases beyond $36$ antennas. Furthermore, nearly one-third of users, even when they are tens of wavelengths apart, have a correlation that is more than twice the correlation of an i.i.d. Rayleigh fading model. Lastly, we characterize the impact of user correlation on system performance. As $M$ increases, conjugate beamforming systems suffer a linearly growing inter-user interference due to correlated channels. However, for zero-forcing beamforming systems, the inter-user interference is a constant that does not increase with M. In particular, zero-forcing beamforming systems can serve a linearly increasing number of correlated users and achieve a linear growth in the system achievable rate as $M$ increases. Hence, spatial multiplexing correlated users can be an attractive massive MIMO design.
Fine-grained Synthesis of Unrestricted Adversarial Examples (2019)

We propose a novel approach for generating unrestricted adversarial examples by manipulating fine-grained aspects of image generation. Unlike existing unrestricted attacks that typically hand-craft geometric transformations, we learn stylistic and stochastic modifications leveraging state-of-the-art generative models. This allows us to manipulate an image in a controlled, fine-grained manner without being bounded by a norm threshold. Our approach can be used for targeted and non-targeted unrestricted attacks on classification, semantic segmentation and object detection models. Our attacks can bypass certified defenses, yet our adversarial images look indistinguishable from natural images as verified by human evaluation. Moreover, we demonstrate that adversarial training with our examples improves performance of the model on clean images without requiring any modifications to the architecture. We perform experiments on LSUN, CelebA-HQ and COCO-Stuff as high resolution datasets to validate efficacy of our proposed approach.
Silicon photonic components for integrated optical systems (2012)

We show that the properties of silicon can be changed profoundly when nanofabricated to below 5nm, resulting in larger bandgap emission and more efficient light generation. Moreover, three-dimensional nanostructures can be fabricated at these nanoscale dimensions by dynamic control over the dry etching process.
Mobile-izing health workers in rural India (2010)

Researchers have long been interested in the potential of ICTs to enable positive change in developing regions communities. In these environments, ICT interventions often fail because political, social and cultural forces work against the changes ICTs entail. We argue that familiar uses of ICTs for information services in these contexts are less potent than their use for persuasion and motivation in order to facilitate change. We focus on India's rural maternal health system where health workers are employed in villages to persuade pregnant women to utilize health services. Health workers face challenges due to resistance to change in the village, and because of their limited education, training and status. These factors appear to reduce the motivation of health workers and impair their performance. For two months, we deployed short videos on mobile phones designed to persuade village women and motivate health workers. We also asked health workers to record their own videos. While our results are preliminary, they show evidence that the creation and use of videos did help (1) engage village women in dialogue, (2) show positive effects toward health worker motivation and learning, and (3) motivate key community influencers to participate in promoting the health workers.
Probing the SAR of dEpoB via Chemical Synthesis:  A Total Synthesis Evaluation of C26-(1,3-dioxolanyl)-12,13-desoxyepothilone B (2002)

A practical total synthesis of 26-(1,3-dioxolanyl)-12,13-desoxyepothilone B (26-dioxolanyl dEpoB) was accomplished in a highly convergent manner. A novel sequence was developed to produce the vinyl iodide segment 17 in high enantiomeric excess, which was used in a key B-alkyl Suzuki merger. Subsequently, a Yamaguchi macrocyclization formed the core lactone, while a selective oxidation and a late stage Noyori acetalization incorporated the dioxolane functionality. Sufficient amounts of synthetic 26-dioxolane dEpoB were produced using this sequence for an in vivo analysis in mice containing xenograft CCRF-CEM tumors.
Plasmid-based vaccines encoding rat neu and immune stimulatory molecules can elicit rat neu-specific immunity. (2003)

DNA vaccines are ideally suited for immunizing against tumor antigens because constructs can be formulated that not only encode the tumor antigen but also encode molecules chosen to improve the ability to elicit an antitumor response. Ligands expressed on antigen-presenting cells associated with stimulating a robust T-cell response are excellent candidates for inclusion in a DNA vaccine. Mice transgenic for the HER-2/neu homologue, rat neu, were immunized with full-length rat neu cDNA given alone or in combination with plasmids encoding costimulatory molecules CD80 or CD86 and the ligand for CD137 (CD137L). Intradermal injection of the plasmid constructs resulted in both plasmid transcript and antigen protein expression being detected in lymph nodes draining the injection site. Immunization with plasmids encoding the neu antigen along with plasmids encoding CD137L and either CD80 or CD86 resulted in the generation of neu-specific antibodies that induced phopshorylation of the neu tyrosine kinase and inhibited the growth of cultured tumor cells overexpressing neu. Survival of animals was significantly prolonged after immunization with vaccines encoding neu together with the costimulatory molecules. Although tumors eventually occurred in the vaccinated animals, they were markedly infiltrated with CD4+ T cells. DNA vaccines encoding neu, when given in combination with both CD137L and either CD80 or CD86, can induce cellular and humoral immunity and result in an antitumor effect.
Parameter Dependence in Continuum Electrostatic Calculations:  A Study Using Protein Salt Bridges (1998)

Continuum electrostatic calculations were carried out for a data set of 21 salt bridges using three sets of parameters (charmm, parse, and a version of opls with slightly exaggerated atomic radii) and three representations of the dielectric boundary (approximate, exact, and smoothed versions of the analytic molecular surface). Comparisons of the overall results and a decomposition into terms due to desolvation, the direct salt bridge, and other interactions with the surrounding protein were used to analyze the effect of differences in parameter sets. It is concluded that (1) while numerical differences among the results can be significant, the underlying tension between desolvation penalty incurred and favorable interactions recovered upon folding is similar in all computations; (2) the largest variation occurs for the desolvation penalty, indicating the importance of fitting this property in parameter development; (3) the approximation of the molecular surface produces the largest desolvation penalties, whereas the smoothed boundary produces the smallest; (4) the exaggerated-radii opls implementation used here resulted in underestimates of the desolvation penalty and overestimates of the bridge interaction, relative to the other parameter sets, for 15 of 21 salt bridges; and (5) although the origins and parameter values are different for the charmm and parse parameter sets, they produce rather similar energetics, due in part to compensating effects.
Cost-Effectiveness and Budget Impact Analyses of Tisagenlecleucel in Pediatric and Young Adult Patients with Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia from the Singapore Healthcare System Perspective (2022)

Tisagenlecleucel is likely to be a cost-effective treatment option with limited budget implications while treating r/r ALL patients who have failed at least 2 lines of prior therapies.
Radiolabeled Antibodies for Therapy of Infectious Diseases (2015)

There is a growing need for alternatives to conventional antibiotics for the treatment of infectious diseases. The number of bacterial pathogens that are resistant even to the most powerful antibiotics is growing each year. HIV remains an incurable disease more than 30 years since its identification. Since 1979 there has been a >200% increase in the annual number of cases of invasive fungal infections in the United States. To exacerbate these problems, the number of patients who cannot fight infections because of impaired immunity is growing and includes HIV patients, patients who have been through cancer chemotherapy, and organ transplant recipients.
Bay of Bengal : a survey of the sea face of the Soondurbuns (1876)

Kartta kuuluu A. E. Nordenskiöldin kokoelmaan
Towards Efficient Automatic Scaling and Adaptive Cost-Optimized eHealth Services in Cloud (2014)

Cloud Computing is an emerging commercial model which allows organizations to eliminate the need to maintain costly hardware, software and network infrastructures. It also permits to avoid the high operational cost for operating and maintaining these infrastructures. Similarly, in the eHealth area, emerging eHealth applications used in conjunction with wearable medical sensor devices and personal devices are being adopted by more and more people with the aim to improve their lifestyle and health. eHealth organizations, willing to provide remote eHealth management, are integrating Wireless Body Area Networks (WBANs) technology and Cloud Computing technology. This integration allows eHealth organizations to deploy their eHealth services on demand and instantly to monitor patients health status. We propose in this paper, a solution for such organizations to efficiently deploy their eHealth services and adapt provisioned physical resources dynamically to satisfy the quality of health of potentially millions of subscribers.
OS1-11 Micro Turbo Pump for Portable Fuel Cells (2006)

We have developed a process to fabricate micro-to-millimeter-sized plastic parts with multilayer microstructures using new low-stress ultrathick photoresist (XP SU-8 3000 series, Kayaku Microchem). Using this process, a 2-dimensional shrouded impeller with 16mm diameter and 400μm blade height was fabricated for a miniature turbo pump supplying air to portable fuel cells. The impeller was glued onto a high-speed magnetic motor, and rotation speed, flow rate and pressure rise was measured. The impeller generated 6.51/min air flow and 0.16kPa pressure rise at 80000rpm.
Metronomic Docetaxel in PRINT Nanoparticles and EZH2 Silencing Have Synergistic Antitumor Effect in Ovarian Cancer (2014)

The purpose of this study was to investigate the antitumor effects of a combination of metronomic doses of a novel delivery vehicle, PLGA-PRINT nanoparticles containing docetaxel, and antiangiogenic mEZH2 siRNA incorporated into chitosan nanoparticles. In vivo dose-finding studies and therapeutic experiments were conducted in well-established orthotopic mouse models of epithelial ovarian cancer. Antitumor effects were determined on the basis of reduction in mean tumor weight and number of metastatic tumor nodules in the animals. The tumor tissues from these in vivo studies were stained to evaluate the proliferation index (Ki67), apoptosis index (cleaved caspase 3), and microvessel density (CD31). The lowest dose of metronomic regimen (0.5 mg/kg) resulted in significant reduction in tumor growth. The combination of PLGA-PRINT-docetaxel and CH-mEZH2 siRNA showed significant antitumor effects in the HeyA8 and SKOV3ip1 tumor models (P < 0.05). Individual as well as combination therapies showed significant antiangiogenic, antiproliferative, and proapoptotic effects, and combination therapy had additive effects. Metronomic delivery of PLGA-PRINT-docetaxel combined with CH-mEZH2 siRNA has significant antitumor activity in preclinical models of ovarian cancer.
Adaptive Time Optimal Control for Ship Steering (1986)

This paper proposes an adaptive time optimal control algorithm for ship steering in course changes. Dynamics of the ship are presented by a third order differential equation model. The time optimal control law is obtained by applying the Successive Order Hightening Method. It is combined with a least squares type parameter estimation algorithm to obtain the adaptive time optimal controller. The proposed control scheme is evaluated by a computer simulation study.
URODYNAMIC EFFECTS OF THE K+ CHANNEL (KCNQ) OPENER RETIGABINE IN FREELY MOVING, CONSCIOUS RATS (2004)

Purpose: Retigabine is a novel anticonvulsant drug that not only augments gamma-aminobutyric acid mechanisms, but also opens voltage gated K+ channels (KCNQ). In this study we investigated the effects of retigabine on detrusor activity in rats. Materials and Methods: To conscious, female Sprague-Dawley rats undergoing continuous cystometry retigabine was given intravenously (0.5, 1 and 5 mg/kg(-1)). The KCNQ channel blocker linopirdine was given intravenously (2 mg/kg(-1)) 5 minutes prior to retigabine (1 mg/kg(-1)). In addition, retigabine was given intracerebroventricularly (1, 5 and 10 mug) and intravesically (100, 500 and 1,000 ng ml(-1)). The effects of the drug (intravesical administration) on capsaicin induced bladder overactivity were also tested. Results: Retigabine given intravenously (1 mg/kg(-1)) decreased baseline and maximal bladder pressures, increased voided and infused volumes, and increased voiding intervals. Retigabine (10 mug) given intracerebroventricularly decreased baseline pressure and increased voided and infused volumes as well as voiding intervals. However, bladder pressures were not significantly affected. Intravesical retigabine (1,000 ng.ml(-1)) decreased maximal bladder pressure, increased voided and infused volumes, and increased voiding intervals. Given intravesically for 30 minutes prior to intravesical capsaicin (30 muM) instillation retigabine (1,000 ng.ml(-1)) decreased the detrusor overactivity induced by capsaicin. The KNCQ channel blocker linopirdine (2 mg/kg(-1)) completely blocked the effects of intravenous retigabine (1 mg/kg(-1)). Conclusions: Retigabine given intravenously, intracerebroventricularly and intravesically increased micturition volume and voiding intervals and, when given intravesically, it decreased capsaicin induced detrusor overactivity, suggesting that KCNQ channels can be interesting targets for drugs aiming at micturition control. Retigabine may be a candidate to test as a treatment for detrusor overactivity in humans.
Cell-Free Massive MIMO With Radio Stripes and Sequential Uplink\n Processing (2020)

Cell-free Massive MIMO (mMIMO) is envisaged to be a next-generation\ntechnology beyond 5G with its high spectral efficiency and superior spatial\ndiversity as compared to that of conventional MIMO technology. The main\nprinciple is that many distributed access points (APs) cooperate to\nsimultaneously serve all the users within the network without creating cell\nboundaries. This paper considers the uplink of a cell-free mMIMO system\nutilizing the radio stripe network architecture. We propose a novel sequential\nprocessing algorithm with normalized linear minimum mean square error (N-LMMSE)\ncombining at every. This algorithm enables interference suppression in\ncell-free MMO while keeping the cost and front-haul requirements low. The\nspectral efficiency of the proposed algorithm is computed and analyzed. We\nconclude that it provides an attractive trade-off between low front-haul\nrequirements and high spectral efficiency.\n
SPILL—Security Properties and Machine-Learning Assisted Pre-Silicon Laser Fault Injection Assessment (2022)

Abstract Laser-based fault injection (LFI) attacks are powerful physical attacks with high precision and controllability. Therefore, attempts have been in the literature to model and simulate the laser effect in pre-silicon digital designs. However, these efforts can only model the laser effect on small SPICE or TCAD circuits of individual standard cells. This paper proposes security properties and a machine-learning assisted layout signoff framework in verifying the full-chip layout's resiliency against LFI. In the framework, we leveraged the commercial SoC power integrity sign-off tool to inject the Gaussian laser current to any spot in the layout, by considering different layout features such as power distribution network, decoupling capacitor placement, metal geometry, instance switching power, etc. To avoid exhaustive analysis of all layout spots regardless of LFI criticality, we use security properties to drive the assessment and identify critical areas. We then use SPICE simulations and machine learning to develop cell-level laser fault models under different laser-induced transient current intensities. This laser cell library is used during full-chip LFI feasibility analysis for the cells inside laser illumination, enabling precise layout -level design fix for critical cells failing the fault injection threshold. Finally, we show the effectiveness of the proposed framework by analyzing the fully implemented AES design layout.
577: The RAF/MAP Kinase Pathway Influences Survival in Androgen-Insensitive Prostate Cancer (2005)

You have accessJournal of UrologyPodium, Sunday, May 22, 2005, 3:30 - 5:30 pm1 Apr 2005577: The RAF/MAP Kinase Pathway Influences Survival in Androgen-Insensitive Prostate Cancer Rono Mukherjee, Sarath K. Nalagatla, Mark A. Undenvood, John M.S. Bartlett, and Joanne Edwards Rono MukherjeeRono Mukherjee More articles by this author , Sarath K. NalagatlaSarath K. Nalagatla More articles by this author , Mark A. UndenvoodMark A. Undenvood More articles by this author , John M.S. BartlettJohn M.S. Bartlett More articles by this author , and Joanne EdwardsJoanne Edwards More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)34817-1AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "577: The RAF/MAP Kinase Pathway Influences Survival in Androgen-Insensitive Prostate Cancer." The Journal of Urology, 173(4S), pp. 157–158 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 173Issue 4SApril 2005Page: 157-158 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Rono Mukherjee More articles by this author Sarath K. Nalagatla More articles by this author Mark A. Undenvood More articles by this author John M.S. Bartlett More articles by this author Joanne Edwards More articles by this author Expand All Advertisement PDF downloadLoading ...
Induction of Hyperintense Signal on T2-Weighted MR Images Correlates with Infusion Distribution from Intracerebral Convection-Enhanced Delivery of a Tumor-Targeted Cytotoxin (2007)

Convection-enhanced infusions frequently do not provide intraparenchymal drug distribution, and these failures can be identified with MRI soon after infusion. When infusions are performed into regions of normal signal intensity, development of hyperintense signal change strongly correlates with the volume and geometry of distribution of infusate.
Alar Notching and Retraction (2016)

*College of Human Ecology, Cornell University, Ithaca, New York; †Department of Medicine (Dermatology), David Geffen School of Medicine, University of California, Los Angeles (UCLA); ‡Department of Dermatologic Surgery, Veteran's Administration, West Los Angeles; §Department of Dermatology, University of California, Irvine (UCI); ‖Private Practice, Newport Beach, California Address correspondence and reprint requests to: Adam M. Rotunda, MD, Private Practice, 1100 Quail Street, Suite 102, Newport Beach, CA 92660, or e-mail: [email protected] The authors have indicated no significant interest with commercial supporters.