gebhart/patrepeval huggingface dataset:
Abstract 177: Brain-Wide Circuit Dynamics of Post-Stroke Recovery After Optogenetic Stimulation (2020)

Background: Post-stroke optogenetic stimulations have been shown to promote functional recovery. However, the cellular and circuit mechanisms underlying such recovery remain unclear. Elucidating key neural circuits in post-stroke recovery will be invaluable for translation of neuromodulation for stroke. Here we used optogenetic functional magnetic response imaging (ofMRI) to examine brain-wide circuit dynamics induced by optogenetic stimulation treatment (OST). Method: Male mice expressing channelrhodopsin (ChR2) in ipsilesional M1 (iM1) layer V excitatory neurons were used. ofMRI were performed on pre-stroke and post-stroke days (PD) 3, 15 and 29. OST were given daily from PD5-15. Sensorimotor tests were conducted one day prior to each ofMRI session. Mice underwent transient middle cerebral artery occlusion (intraluminal suture model, 30 minutes). Two groups were assigned: stim group (mice with 10 days of OST, n=9) and no stim group (mice without OST, n=9). Activation maps were compared between stim and no stim groups to reveal key brain circuits recovered by OST. The expression of plasticity marker GAP43 was examined using western blot. Result: Our results show that 1) Optogenetic excitatory neuronal stimulations in iM1 promotes motor function at PD 14 (P&lt;0.01). 2) At pre-stroke, iM1 stimulations activate expected network including ipsilesional M1, M2, S1, striatum, thalamus, contralateral M1 and cerebellum. 3) At PD3, all mice exhibit a depressed response throughout the brain. 4) At PD15, ipsilesional thalamus and S1 circuits are significantly recovered by OST. Moreover, restoration of thalamic activation is correlated with behavioral recovery in the stim group. 5) At PD15, stimulated mice exhibited higher level of plasticity marker (GAP43) in the ipsilesional thalamus (P&lt;0.05). 6) At PD29, iS1 activation remains stronger in the stim group when compared to no stim group. Conclusion: Our findings revealed key circuits underlying stimulation-induced post-stroke recovery. We found that restoration of cortico-thalamic projections is important in stimulation-induced recovery at early phase post-stroke, while sustained strengthening of ipsilesional cortico-cortical connections may be critical in the later phase of recovery.
Local Recurrence Following Resection of Intermediate-High Risk Nonmetastatic Renal Cell Carcinoma: An Anatomical Classification and Analysis of the ASSURE (ECOG-ACRIN E2805) Adjuvant Trial (2019)

In patients with intermediate-high risk nonmetastatic renal cell carcinoma local recurrence appears to be a function of biology more than of surgical modality or surgery type. The prognosis for solitary intra-abdominal local recurrences appear similar regardless of location (types I-III). Local recurrences involving multiple sites and/or subdivisions are associated with worse survival (type IV).
C-11. An Update on Gene Therapy for the Treatment of Aromatic L-Amino Acid Decarboxylase (AADC) Deficiency (2015)

Aromatic L-amino acid decarboxylase (AADC) is an enzyme responsible for the final step of the synthesis of neurotransmitters dopamine and serotonin. AADC deficiency is a rare genetic disorder causing motor and autonomic dysfunction and early death in children. Taiwanese carry a high prevalence of AADC deficiency due to a founder mutation (IVS6+4A>T) in the AADC gene. A gene therapy with recombinant adeno-associated virus (AAV) serotype 2 CMV promoter-driven human AADC (AAV2-hAADC) was conducted in children with AADC deficiency since 2010. Clinical grade vector was manufactured. Two target points were determined in each putamen and a total of 1.7×1011 vg vector was injected. Eight patients have been treated at a mean age of 4.9 years (2-8 years), and the mean follow up period was 3.8 years (3-4.5 years). All patients, except one, had homozygous IVS6+4A>T mutations. Before gene therapy, these patients didn't have head control, and could not sit or stand, and they all had regular and severe oculogyric crisis (OGC) attacks. The stereotaxic surgeries were performed smoothly and there was no intracerebral bleeding. At the most recently follow-up visits after gene therapy, one patient was learning walking, two stood with support, one sat without assist, and three had better head control. The severity of OGC decreased and emotion stabilized in all patients. [18F]fluoro-dopa positron emission tomography (PET) signal intensity over putamen increased and cerebrospinal fluid neurotransmitter levels rose in all treated patients. Post gene therapy transient (orofacial) dyskinesia was the main adverse event of the treatment, and one patient experienced a hypovolemic shock due to dyskinesia and he remained bed-ridden. There is no virus-associated side effect, and currently no patient reveals a loss of treatment effect.
Zenseact Open Dataset: A large-scale and diverse multimodal dataset for autonomous driving (2023)

Existing datasets for autonomous driving (AD) often lack diversity and long-range capabilities, focusing instead on 360° perception and temporal reasoning. To address this gap, we introduce Zenseact Open Dataset (ZOD), a large-scale and diverse multimodal dataset collected over two years in various European countries, covering an area 9x that of existing datasets. ZOD boasts the highest range and resolution sensors among comparable datasets, coupled with detailed keyframe annotations for 2D and 3D objects (up to 245m), road instance/semantic segmentation, traffic sign recognition, and road classification. We believe that this unique combination will facilitate breakthroughs in long-range perception and multi-task learning. The dataset is composed of Frames, Sequences, and Drives, designed to encompass both data diversity and support for spatio-temporal learning, sensor fusion, localization, and mapping. Frames consist of 100k curated camera images with two seconds of other supporting sensor data, while the 1473 Sequences and 29 Drives include the entire sensor suite for 20 seconds and a few minutes, respectively. ZOD is the only large-scale AD dataset released under a permissive license, allowing for both research and commercial use. More information, and an extensive devkit, can be found at https://zod.zenseact.com
A Real-life Test of Face Recognition System for Dialogue Interface Robot in Ubiquitous Environments (2006)

This paper discusses a face recognition system for a dialogue interface robot that really works in ubiquitous environments and reports an experimental result of real-life test in a ubiquitous environment. While a central module of the face recognition system is composed of the decomposed eigenface method, the system also includes a special face detection module and the face registration module. Since face recognition should work on images captured by a camera equipped on the interface robot, all the methods are tuned for the interface robot. The face detection and recognition modules accomplish robust face detection and recognition when one of the registered users is talking to the robot. Some interesting results are reported with careful analysis of a sufficient real-life experiment
Effect of pumping configuration on noise figure and efficiency for 0.98-μm-pumped saturated erbium-doped fiber amplifiers (1993)

We report the results of an investigation of the noise figure and conversion efficiency of erbium-doped fiber amplifiers for unsaturated, moderately saturated and heavily saturated operation. Quantum-limited 3 dB noise figures result only for small signal operation of low gain amplifiers. For high gain, partially saturated amplifiers, useful as in-line repeaters, bi- directional pumping results in the best combination of noise performance and conversion efficiency while co-propagation of signal and pump produces the best noise performance.
Lithium‐Ion Batteries: Nanostructured Fe3O4/SWNT Electrode: Binder‐Free and High‐Rate Li‐Ion Anode (Adv. Mater. 20/2010) (2010)

A flexible carbon nanotube net is employed to demonstrate high capacity/high volume expansion materials for Li-ion battery electrodes, as presented by A. C. Dillon et al. on page E145. An electrode, with well over twice the capacity of the state-of-the-art technology, charges and discharges in 12 minutes without significant capacity fade. These advancements, funded by the US Department of Energy, Office of Vehicle Technologies Program, will help enable next generation electric vehicles.
Low-Power 12-bit 160-MS/s Pipeline A/D Converters (2008)

Low-power 12-bit 160-MS/s pipeline A/D converters are designed for wireless receivers. Instead of using ultra-deep submicron devices of low supply voltage, we employ analog-option devices that operate at supply voltage of 2.5V in a 90-㎚ CMOS process. To achieve lower power dissipation, an I/Q amplifier sharing technique is employed. Furthermore, charge transfer level shifters are proposed in S/H circuits and MDACs for realizing class-AB operation. The area is 1.1㎟, the simulated power dissipation is 75㎽/channel and the simulated ENOB is 11.15bit.
ChemInform Abstract: A New Method for the Selective Bridge Functionalization of [2.2]Paracyclophanediene — Indenyl‐Anellated [2.2]Paracyclophanedienes and Their Iron Complexes. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Wire Less Sensors for Electromechanical Systems Diagnostics (2018)

The diagnostic machinery monitoring system presented in this paper coordinates the acquisition of vibration and speed estimates for an electric machine. It functions even when the machine is “off” or spinning down. This effectively turns the machine into its own mechanical network analyzer. Data from this system can be used to correlate electrical and mechanical data in order to distinguish a variety of pathologies in the machine and its mechanical mounts. The entire sensor system powers itself from surrounding magnetic fields, requiring no ohmic contact or special power wiring. The system presented in this paper presents a unique approach for fusing data from multiple sensors to create a coordinated picture of machine operation on a self-powered platform.
A Chromosome-length Assembly of the Black Petaltail ( Tanypteryx hageni ) Dragonfly (2022)

Abstract We present a chromosome-length genome assembly and annotation of the Black Petaltail dragonfly ( Tanypteryx hageni ). This habitat specialist diverged from its sister species over 70 million years ago, and separated from the most closely related Odonata with a reference genome 150 million years ago. Using PacBio HiFi reads and Hi-C data for scaffolding we produce one of the most high quality Odonata genomes to date. A scaffold N50 of 206.6 Mb and a BUSCO score of 96.8% indicate high contiguity and completeness. Significance We provide a chromosome-length assembly of the Black Petaltail dragonfly ( Tanypteryx hageni) , the first genome assembly for any non-libelluloid dragonfly. The Black Petaltail diverged from its sister species over 70 million years ago. T. hageni , like its confamilials, occupies fen habitats in its nymphal stage, a life history uncommon in the vast majority of dragonflies. We hope that the availability of this assembly will facilitate research on T. hageni and other petaltail species, to better understand their ecology and support conservation efforts.
Power Line Communication Experiment using Wavelet OFDM in U.S.. (2005)

Recently, the demand of high speed network in home is increasing, and PLC is expected as one of the solutions. We can see related researches on the high speed PLC system using a frequency band 2 MHz to 30 MHz. In this paper, we propose a wavelet based OFDM as a suitable method for realizing the high speed PLC system. The proposed wavelet OFDM method is composed of the M-band transmultiplexer which consists of the perfect reconstruction cosine-modulated filter bank. And the attenuation of the first side-lobe is above 35dB, which is a characteristic of the proposed method. As a result, we show that the proposed method has the inter-carrier interference characteristic which is superior to FFT-OFDM, and it also provides the flexible notch filter function which can reduce the influence on other communication systems existing in the communication band which the PLC uses. Finally, we describe that the simulation results about the BER characteristic of the proposed method in AWGN were almost the same as the theory, and that transmission rates which were measured by using prototype modems in a field test house in U.S. were above 35Mbps.
Analysis of Stresses in Metal Sheathed Thermocouples in High-Temperature Flows (2021)

Flight and ground test applications for in-flow and near-wall flow temperature sensing demand robust and accurate sensing, making thermocouple sensors attractive. Even for these extremely well-developed sensors, an accurate prediction of stresses within thermocouple sheaths for custom-configured probes remains a topic of great concern for ensuring an adequate lifetime of sensors. In contemporary practice, high-fidelity simulations must be run to prove survivability, albeit at significant time and expense. Given the resources it takes to run high-fidelity simulations, rapid optimization of sensor configurations is often impossible or, at a minimum, impractical. The developments presented in this paper address the need for high-temperature sensor structural predictions that are compatible with rapid design iteration. The derivation and implementation of a new analytical, low-order model to predict stresses within the sheath of a thermocouple are provided. The analytical model is compared to three-dimensional elastic finite element method simulations as well as experimental data from a simplified configuration. The low-order model sheath stress predictions, which are critical to probe survival, are in excellent agreement with the numerically simulated results and experimental results with root-mean-squared percentage errors of approximately 1.2 and 2.6%, respectively, thus, validating the model.
WNet: A Data-Driven Dual-Domain Denoising Model for Sparse-View Computed Tomography With a Trainable Reconstruction Layer (2023)

Deep learning based solutions are being succesfully implemented for a wide variety of applications. Most notably, clinical use-cases have gained an increased interest and have been the main driver behind some of the cutting-edge data-driven algorithms proposed in the last years. For applications like sparse-view tomographic reconstructions, where the amount of measurement data is small in order to keep acquisition time short and radiation dose low, reduction of the streaking artifacts has prompted the development of data-driven denoising algorithms with the main goal of obtaining diagnostically viable images with only a subset of a full-scan data. We propose WNet, a data-driven dual-domain denoising model which contains a trainable reconstruction layer for sparse-view artifact denoising. Two encoder-decoder networks perform denoising in both sinogram- and reconstruction-domain simultaneously, while a third layer implementing the Filtered Backprojection algorithm is sandwiched between the first two and takes care of the reconstruction operation. We investigate the performance of the network on sparse-view chest CT scans, and we highlight the added benefit of having a trainable reconstruction layer over the more conventional fixed ones. We train and test our network on two clinically relevant datasets and we compare the obtained results with three different types of sparse-view CT denoising and reconstruction algorithms.
Nocturnal Positive Pressure Ventilation Via A Nasal Mask (1987)

"Nocturnal Positive Pressure Ventilation Via A Nasal Mask." American Review of Respiratory Disease, 136(3), pp. 791–792
Bipolar Degradation of High Voltage 4H-SiC <i>p-i-n</i> Diodes in Pulse Regime (2011)

We report on specific features of forward voltage degradation of 4H-SiC p-i-n diodes in the pulse mode. It is shown that pulse stresses with a pulse duration shorter than several milliseconds cause substantially smaller forward voltage drift in comparison with a dc stress with the same charge passed through the diodes and the same distribution of injected carriers. A self-recovery of the forward voltage is observed at room temperature.
RUNXsuper-enhancer control through the Notch pathway by Epstein-Barr virus transcription factors regulates B cell growth (2016)

In B cells infected by the cancer-associated Epstein-Barr virus (EBV), RUNX3 and RUNX1 transcription is manipulated to control cell growth. The EBV-encoded EBNA2 transcription factor (TF) activates RUNX3 transcription leading to RUNX3-mediated repression of the RUNX1 promoter and the relief of RUNX1-directed growth repression. We show that EBNA2 activates RUNX3 through a specific element within a -97 kb super-enhancer in a manner dependent on the expression of the Notch DNA-binding partner RBP-J. We also reveal that the EBV TFs EBNA3B and EBNA3C contribute to RUNX3 activation in EBV-infected cells by targeting the same element. Uncovering a counter-regulatory feed-forward step, we demonstrate EBNA2 activation of a RUNX1 super-enhancer (-139 to -250 kb) that results in low-level RUNX1 expression in cells refractory to RUNX1-mediated growth inhibition. EBNA2 activation of the RUNX1 super-enhancer is also dependent on RBP-J. Consistent with the context-dependent roles of EBNA3B and EBNA3C as activators or repressors, we find that these proteins negatively regulate the RUNX1 super-enhancer, curbing EBNA2 activation. Taken together our results reveal cell-type-specific exploitation of RUNX gene super-enhancers by multiple EBV TFs via the Notch pathway to fine tune RUNX3 and RUNX1 expression and manipulate B-cell growth.
Lack of Pharmacokinetic Interactions Between Macitentan and a Combined Oral Contraceptive in Healthy Female Subjects (2015)

Macitentan, a dual endothelin receptor antagonist used in pulmonary arterial hypertension, induces cytochrome P450 (CYP) 3A at supratherapeutic concentrations in vitro. Most combined oral hormonal contraceptives (OCs) are CYP3A substrates and their efficacy can be affected by CYP3A inducers. This randomized crossover study assessed possible pharmacokinetic (PK) interactions between macitentan and an OC containing ethinyl estradiol and norethindrone (or norethisterone). Twenty-six healthy women received a single oral dose of OC alone (reference) and concomitantly with 10 mg macitentan at steady state (test). No PK interaction was concluded if the 90% confidence intervals (CIs) of geometric mean ratios (GMRs; test/reference) of the peak plasma concentration (Cmax ) and the exposure from 0 to infinity (AUC0 - ∞ ) to the OC components were within the equivalence limits of 0.8 to 1.25. Cmax and AUC0-∞ of the OC were within the equivalence limits. For ethinyl estradiol, GMRs (90%CIs) of Cmax and AUC0-∞ were 0.92 (0.85-0.99) and 0.95 (0.90-0.99). For norethindrone, these values were 1.02 (0.95-1.09) and 1.04 (0.98-1.09), respectively. Overall, study treatments were well tolerated. No major changes from baseline in safety parameters were reported in either treatment. Macitentan does not affect the PK of OCs.
Comparing long-term results of PASAT and SDMT scores in relation to neuropsychological testing in multiple sclerosis (2013)

As a single assessment tool for cognition in MS, the SDMT is more valid and reliable compared to PASAT3.
Impact of SET and RESET conditions on CBRAM high temperature data retention (2014)

In this paper, we investigate the high temperature behavior of oxide-based conductive bridge memories. A methodology to optimize both high and low resistance states stability is presented. A numerical model is developed able to simulate the filament dissolution over time. This allows us to establish a clear correlation between the filament morphology and the ON/OFF states stability. It is shown that the optimization of the memory programming conditions leads to a stable memory window up to 250°C.
SARS-CoV-2 Exposure in Escaped Mink, Utah, USA (2021)

In August 2020, outbreaks of coronavirus disease were confirmed on mink farms in Utah, USA. We surveyed mammals captured on and around farms for evidence of infection or exposure. Free-ranging mink, presumed domestic escapees, exhibited high antibody titers, suggesting a potential severe acute respiratory syndrome coronavirus 2 transmission pathway to native wildlife.
IC‐P‐058: AUTOMATED HIPPOCAMPAL SEGMENTATION USING NEW STANDARDIZED MANUAL SEGMENTATIONS FROM THE HARMONIZED HIPPOCAMPAL PROTOCOL (2014)

Hippocampal volumetry derived from structural magnetic resonance imaging (MRI) has been endorsed by the Alzheimer's disease (AD) diagnostic guidelines as a radiological marker of disease progression. Among the top performing automated hippocampal segmentation methods are multi-atlas segmentation methods, which rely on manual annotations. In this study, we investigate a combination of such method with annotations from a new Harmonized Hippocampal Protocol (HHP). We compare its capabilities to a FreeSurfer method and verify its impact on segmentation and diagnostic group separation capabilities. 40 manual HHP hippocampal annotations (12 normal control (NC), 11 mild cognitive impairment (MCI), 17 AD) were transformed to a common segmentation space. The corresponding 1.5T MRIs were preprocessed using FreeSurfer. An automated Non-Local Patch-based segmentation technique (N-L Patch) was used to segment the left- and right hippocampus, separately. All 40 HHP annotations were used as atlases during pre-selection, but only the 9 most similar contributed to the final segmentation. Leave-one-out crossvalidation was performed on the 40 atlases, and the corresponding DICE-scores with the manual annotations were calculated. A standardized ADNI dataset containing 1.5T MRIs from 504 subjects (169 NC, 234 MCI, 101 AD) at baseline and month 12 was segmented using the method described above and atrophy rate calculated as percentage volume change was estimated. Mean (±sd) cross-validation DICE-scores of the 40 atlases segmented using N-L Patch and cross-sectional FreeSurfer were 0.868 (±0.019) and 0.781 (±0.031), respectively. A paired t-test between N-L Patch and FreeSurfer DICE-scores showed significance (p<0.001). Statistics in terms of AUC and Cohens' D were used to evaluate differences in atrophy rates between diagnostic groups for N-L Patch and FreeSurfer segmentations. N-L Patch performed significantly better in separating AD from NC and AD from MCI, Table 1. Including the HHP labels in a multi-atlas segmentation method resulted in better segmentation consensuses with the new hippocampal label standard than a state-of-the-art method, FreeSurfer. Furthermore, N-L Patch yielded significantly better group separation than FreeSurfer in separating AD from NC and AD from MCI. This illustrates the longitudinal robustness of segmentations when annotations from the new hippocampal label standard are included in automated segmentation methods.
Relational time for systems of oscillators (2005)

Using an elementary example based on two simple harmonic oscillators, we show how a relational time may be defined that leads to an approximate Schrodinger dynamics for subsystems, with corrections leading to an intrinsic decoherence in the energy eigenstates of the subsystem.