gebhart/patrepeval huggingface dataset:
Body Mass Index and Treatment Response in Patients with Cardiac Light-Chain Amyloidosis (2021)

Elevated body mass index (BMI) has been associated with an increased risk of cancer and has been shown to have a negative impact on survival in patients with breast, prostate, oral cancer, and leukemia.
Case for a700+GeVWIMP: Cosmic ray spectra from PAMELA, Fermi, and ATIC (2009)

Multiple lines of evidence indicate an anomalous injection of high-energy ${e}^{+}{e}^{\ensuremath{-}}$ in the galactic halo. The recent ${e}^{+}$ fraction spectrum from the payload for antimatter matter exploration and light-nuclei astrophysics (PAMELA) shows a sharp rise up to 100 GeV. The Fermi gamma-ray space telescope has found a significant hardening of the ${e}^{+}{e}^{\ensuremath{-}}$ cosmic-ray spectrum above 100 GeV, with a break, confirmed by HESS at around 1 TeV. The advanced thin ionization calorimeter (ATIC) has also detected a similar excess, falling back to the expected spectrum at 1 TeV and above. Excess microwaves towards the galactic center in the WMAP data are consistent with hard synchrotron radiation from a population of 10--100 GeV ${e}^{+}{e}^{\ensuremath{-}}$ (the WMAP ``Haze''). We argue that dark matter annihilations can provide a consistent explanation of all of these data, focusing on dominantly leptonic modes, either directly or through a new light boson. Normalizing the signal to the highest energy evidence (Fermi and HESS), we find that similar cross sections provide good fits to PAMELA and the Haze, and that both the required cross section and annihilation modes are achievable in models with Sommerfeld-enhanced annihilation. These models naturally predict significant production of gamma rays in the galactic center via a variety of mechanisms. Most notably, there is a robust inverse-Compton scattered (ICS) gamma-ray signal arising from the energetic electrons and positrons, detectable at Fermi/GLAST energies, which should provide smoking gun evidence for this production.
Applications of controlled-flow laser-polarized xenon gas to porous and granular media study (2002)

We report initial NMR studies of continuous flow laser-polarized xenon gas, both in unrestricted tubing, and in a model porous media. The study uses Pulsed Gradient Spin Echo-based techniques in the gas-phase, with the aim of obtaining more sophisticated information than just translational self-diffusion coefficients. Pulsed Gradient Echo studies of continuous flow laser-polarized xenon gas in unrestricted tubing indicate clear diffraction minima resulting from a wide distribution of velocities in the flow field. The maximum velocity experienced in the flow can be calculated from this minimum, and is seen to agree with the information from the complete velocity spectrum, or motion propagator, as well as previously published images. The susceptibility of gas flows to parameters such as gas mixture content, and hence viscosity, are observed in experiments aimed at identifying clear structural features from echo attenuation plots of gas flow in porous media. Gas-phase NMR scattering, or position correlation flow-diffraction, previously clearly seen in the echo attenuation data from laser-polarized xenon flowing through a 2 mm glass bead pack is not so clear in experiments using a different gas mixture. A propagator analysis shows most gas in the sample remains close to static, while a small portion moves through a presumably near-unimpeded path at high velocities.
The Absorption by Free Carriers in n-type AgCuSe (2000)

In the ternary compound of n-type AgCuSe the absorption by free carriers in the range 2.5-25 µ was observed. There are two processes of absorption on the spectrogram α∼(hν). The coefficient of optical absorption by free carriers of a charge, corresponds to the classical Droode-Lowrens theory. The spectral dependence of electronic losses -J m ε -1 (ω), dielectric constants ε 1 and ε 2 have been estimated
Les procedes de refusion en creuset froid : analyse des parametres cles (1990)

This work is in the general framework of research studies in the field of engineering of materials processes at high temperature. Two main concerns are : first analysis of physical phenomena involved in a particular process : i.e. the cold induction crucible; secondly, consideration of particular applications for the development of a specified product with fixed properties. The main objective has always been to establish clear links between key process parameters and characteristics of the product.
Expanding the Quantum Photonic Toolbox with Low-Loss AlGaAs-on-Insulator (2022)

We present the building blocks for a programmable quantum processor with AlGaAs-on-insulator integrated photonics, including low-loss waveguide crossers and &gt; 30 dB extinction tunable interferometers, which we benchmark via photonic qubit demultiplexing with high extinction.
Expression of Mutant Huntingtin Blocks Exocytosis in PC12 Cells by Depletion of Complexin II (2003)

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by an expanded CAG repeat in the HD gene. We reported recently that complexin II, a protein involved in neurotransmitter release, is depleted from both the brains of mice carrying the HD mutation and from the striatum of post mortem HD brains. Here we show that this loss of complexin II is recapitulated in PC12 cells expressing the HD mutation and is accompanied by a dramatic decline in Ca2+-triggered exocytosis of neurotransmitter. Overexpression of complexin II (but not complexin I) rescued exocytosis, demonstrating that the decline in neurotransmitter release is a direct consequence of complexin II depletion. Complexin II depletion in the brain may account for some of the abnormalities in neurotransmission associated with HD.
Cloning and characterization of the prostate-specific membrane antigen promoter (1999)

Prostate-specific membrane antigen (PSMA) is a protein that is expressed predominantly in normal prostate epithelial cells and in most adenocarcinomas of the prostate (Cap) and in virtually all Cap metastases. In this article we describe the cloning of a 2-kb human genomic DNA fragment containing the 5' upstream untranslated region of the PSMA gene and present evidence that it provides promoter activity. When the DNA fragment was cloned into transient expression vectors to examine promoter activity, the vectors were functional in promoting expression in several prostate and nonprostate cell lines in transient transfection assays. A 614-bp fragment derived from the 3' end of the 2-kb fragment may represent the minimal PSMA promoter as determined by deletion mutagenesis. The 2-kb fragment compared with the 614-bp fragment provided higher expression levels when using prostate-derived cell lines (DU 145 and LNCaP). The increased transcription using the 2-kb fragment was not as great in non-prostate cell lines. Little or no transcription over basal levels was seen with a 232-bp promoter fragment. When the concentration of dihydrotestosterone was depleted or supplemented in the growth medium, no significant effect was seen on PSMA-promoted transient expression in LNCaP cells, a prostate cell line. J. Cell. Biochem. 74:395-405, 1999. Published 1999 Wiley-Liss, Inc.
One-to-one Mapping for Unpaired Image-to-image Translation (2019)

Recently image-to-image translation has attracted significant interests in the literature, starting from the successful use of the generative adversarial network (GAN), to the introduction of cyclic constraint, to extensions to multiple domains. However, in existing approaches, there is no guarantee that the mapping between two image domains is unique or one-to-one. Here we propose a self-inverse network learning approach for unpaired image-to-image translation. Building on top of CycleGAN, we learn a self-inverse function by simply augmenting the training samples by swapping inputs and outputs during training and with separated cycle consistency loss for each mapping direction. The outcome of such learning is a proven one-to-one mapping function. Our extensive experiments on a variety of datasets, including cross-modal medical image synthesis, object transfiguration, and semantic labeling, consistently demonstrate clear improvement over the CycleGAN method both qualitatively and quantitatively. Especially our proposed method reaches the state-of-the-art result on the cityscapes benchmark dataset for the label to photo unpaired directional image translation.
Abstract 49: Modulating insulin receptor splicing as a potential therapeutic approach for rhabdomyosarcoma (2017)

Abstract The insulin receptor (IN-R) is subject to alternative splicing to produce two isoforms: the full-length IN-R B isoform and an isoform lacking exon 11 known as IN-R A which is the predominant isoform expressed in sarcoma cells. This short exon encodes for 12 amino acids but the resulting receptor has high affinity for a growth hormone called insulin-like growth factor 2 (IGF2), which exquisitely responds to autocrine and paracrine signaling. Increased IN-R A levels observed in rhabdomyosarcoma (RMS) coupled with increased expression of IGF2, programs the tumor cell for enhanced growth and angiogenesis, two important factors in tumorigenesis. Furthermore, IGF2 can maintain angiogenesis through IN-R A when the cognate receptor for IGF2, the IGF-1 receptor, is blocked. Interestingly we have shown that hypoxia increases alternative splicing to produce more IN-R A. This is an interesting finding since adaptation to the hypoxic environment is a hallmark of the neoplastic phenotype. Therefore, we hypothesize that expression of splicing factors is altered under hypoxic conditions which leads to increased alternative splicing and generation of IN-R A, allowing the cancer cells a growth advantage which contributes to metastasis beyond the micrometastatic phase. To characterize sequence elements and splicing factors involved in the regulation of IN-R alternative splicing, we have developed a hypoxia-inducible splicing system, which recapitulates the splicing patterns observed in tumors. We have shown that sequence elements preceding exon 11 are critical to the increased alternative splicing we see under hypoxic conditions. As such, we have targeted these regions for antisense oligonucleotide (ASO) development to increase full-length splicing of IN-R, with the goal of restricting proliferative signaling by IGF2 activation of IN-R A. We performed an ASO walk to target regions important for exon inclusion or exclusion and have successfully targeted a region known to be a binding site for the splicing factor CUGBP1. RMS-derived cell lines almost exclusively express IN-R A but when treated with our lead ASO compound we see a dramatic decrease in alternative splicing resulting in increased levels of the full-length insulin receptor. We have also shown that RMS-derived cells treated with our splice modulating ASO exhibit reduced cell proliferation and migratory properties. With these promising data we postulate that modulation of IN-R splicing can be used in conjunction with already established anti-IGF-1 receptor therapies in the treatment of RMS. Citation Format: Brianne Sanford, Chelsea Brown, Hemant Bid, Thomas Beebe, Daniel Comiskey, Frank Rigo, Peter Houghton, Dawn Chandler. Modulating insulin receptor splicing as a potential therapeutic approach for rhabdomyosarcoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 49. doi:10.1158/1538-7445.AM2017-49
Erratum [regarding "High Spectral Efficiency 400 Gb/s Transmission Using PDM Time-Domain Hybrid 32-64 QAM and Training-Assisted Carrier Recovery"] (2013)

The following article "High Spectral Efficiency 400 Gb/s Transmission Using PDM Time-Domain Hybrid 32-64 QAM and Training-Assisted Carrier Recovery" by High Spectral Efficiency 400 Gb/s Transmission, et al. [ibid., vol. 31, no. 7, pp. 999-1005, Apr. 2013] was inadvertently omitted from the Special Issue on Optical Fiber Communications/National Fiber Optics Engineers Conference 2012: High Spectral Efficiency 400 Gb/s Transmission Using PDM Time-Domain Hybrid 32-64 QAM and Training-Assisted Carrier Recovery.
The surface properties of SOA generated from limonene and toluene using specific molecular probes: exploration of a new experimental technique (2005)

Abstract. A new experimental technique of characterizing the aerosol-atmosphere surface has been explored using three examples: the secondary organic aerosols (SOA) resulting from the reaction of limonene with O3 and from the photooxidation of toluene in comparison with the combustion aerosol (soot) from a toluene diffusion flame. Rather than investigating the bulk composition of the aerosol by complete chemical analysis and identification of the many dozens if not more of constituent compounds we have interrogated the type and number of functional groups located at the aerosol surface by interacting them with specific molecular probes such as O3, NO2, N(CH3)3, and NH2OH to probe for the presence of oxidizable sites, acidic sites and carbonyl functionalities, respectively, that are present on the surface of the aerosol particle. In practice, typical amounts of one to a few mg of laboratory-generated SOA of limonene, toluene and soot have been deposited on a PTFE membrane filter that subsequently has been transferred to a molecular flow reactor used for the titration reaction of the surface functional groups by the molecular probes. Absolute amounts Ni with i=O3, NO2, N(CH3)3, NH2OH of probe molecules taken up by the filter sample measured using molecular beam sampling mass spectrometry have been converted into the number of surface group functionalities per unit surface area S using the aerosol particle distribution function (PDF) of limonene and toluene SOA and the BET total surface area of toluene flame soot to result in Ni/S. Arguments are presented that support the transfer of the PDF of the suspended to the aerosol collected on the Teflon filter.
ChemInform Abstract: Future of the Particle Replication in Nonwetting Templates (PRINT) Technology (2013)

Abstract Review: recent work involving the PRINT technology for application in biomedical and material sciences; 77 refs.
Exenatide modulates visual cortex responses (2019)

In both lean and obese individuals, exenatide affects neural processing in visual cortex, both in early visual areas and in higher order areas. This effect may contribute to the known effect of GLP1 analogues on food-related behaviour.
Reliable large-area germanium photodetectors fabricated with a diffused junction from in situ III-V epitaxial material (2003)

Low cost germanium photodetectors for sensing applications in the 900-1600 nm spectral region have been developed. By varying the Ge substrate resistivity as well as device area, photodetector properties such as reverse leakage current, capacitance, and shunt resistance have been engineered. Low leakage current devices of various sizes up to 1 cm<sup>2</sup> have been fabricated and have consistently exhibited exceptionally high shunt resistances and excellent linearity. Over 5000 hours of active stress testing have left the ultra-low leakage currents unchanged. These data were measured in accordance with Telcordia 468-CORE requirements at 85&deg;C, 125&deg;C and 175&deg;C. The results indicate that these mesa photodetectors meet telecommunication industry requirements for reliability. These devices are comparable to commercially available Ge photodetectors, and can be readily substituted for more complex InGaAs photo-detectors in applications such as laser monitor diodes.
Substantial increase in number and dosage of antipsychotics in non-responsive vs. responsive schizophrenia inpatients (2003)

INTRODUCTION Current clinical guidelines recommend the use of a single antipsychotic drug for acute schizophrenic exacerbation. We examined whether this approach is also employed in non-responsive schizophrenia inpatients. METHODS Forty-one consecutively admitted schizophrenic inpatients were assigned into a study group [n=22; non-responsive (ΔBPRS&lt;10%) to two consecutive trials of antipsychotics prior to and following 24 weeks of hospitalization] and a comparison group [n=19; partial-to-good (ΔBPRS=10-27%) responders under similar settings]. RESULTS The number and dosage of antipsychotics were increased by 34% and 40% (P=0.016 and P=0.062, respectively) in the study group compared to the comparison subjects following 24 weeks of hospitalization. In the study group, a significant correlation was found between the number of antipsychotics administered and their dose (r=0.22, n=88, P=0.04). CONCLUSION Clinicians do not comply with evidence-based algorithms, and treat non-responsive schizophrenia inpatients with a combination of antipsychotics and at substantially higher doses compared to partial-to-good responders. Our findings discourage such practice.
Single-row Versus Double-row Rotator Cuff Repair: Techniques and Outcomes (2010)

Double-row rotator cuff repair techniques incorporate a medial and lateral row of suture anchors in the repair configuration. Biomechanical studies of double-row repair have shown increased load to failure, improved contact areas and pressures, and decreased gap formation at the healing enthesis, findings that have provided impetus for clinical studies comparing single-row with double-row repair. Clinical studies, however, have not yet demonstrated a substantial improvement over single-row repair with regard to either the degree of structural healing or functional outcomes. Although double-row repair may provide an improved mechanical environment for the healing enthesis, several confounding variables have complicated attempts to establish a definitive relationship with improved rates of healing. Appropriately powered rigorous level I studies that directly compare single-row with double-row techniques in matched tear patterns are necessary to further address these questions. These studies are needed to justify the potentially increased implant costs and surgical times associated with double-row rotator cuff repair.
Synchronized Fast SPE and UFLC Methods for the Analyses of Eight Antidiabetic Drugs in Human Plasma (2017)

The validated method was fruitfully adopted to analyze these drugs in human plasma for the clinical monitoring of these drugs.
Profile of dyslipidemia in Psammomys obesus, an animal model of the metabolic syndrome. (2002)

These data suggest that the dyslipidemia in obese, diabetic Psammomys obesus is closely associated with other components of the Metabolic Syndrome, including obesity and insulin resistance.
Colony-Stimulating Factors Signal for Increased Transport of Vitamin C in Human Host Defense Cells (1998)

Although serum concentrations of ascorbic acid seldom exceed 150 μmol/L, mature neutrophils and mononuclear phagocytes accumulate millimolar concentrations of vitamin C. Relatively little is known about the mechanisms regulating this process. The colony-stimulating factors (CSFs), which are central modulators of the production, maturation, and function of human granulocytes and mononuclear phagocytes, are known to stimulate increased glucose uptake in target cells. We show here that vitamin C uptake in neutrophils, monocytes, and a neutrophilic HL-60 cell line is enhanced by the CSFs. Hexose uptake studies and competition analyses showed that dehydroascorbic acid is taken up by these cells through facilitative glucose transporters. Human monocytes were found to have a greater capacity to take up dehydroascorbic acid than neutrophils, related to more facilitative glucose transporters on the monocyte cell membrane. Ascorbic acid was not transported by these myeloid cells, indicating that they do not express a sodium-ascorbate cotransporter. Granulocyte (G)- and granulocyte-macrophage colony-stimulating factor (GM-CSF) stimulated increased uptake of vitamin C in human neutrophils, monocytes, and HL-60 neutrophils. In HL-60 neutrophils, GM-CSF increased both the transport of dehydroascorbic acid and the intracellular accumulation of ascorbic acid. The increase in transport was related to a decrease in Km for transport of dehydroascorbic acid without a change in Vmax. Increased ascorbic acid accumulation was a secondary effect of increased transport. Triggering the neutrophils with the peptide fMetLeuPhe led to enhanced vitamin C uptake by increasing the oxidation of ascorbic acid to the transportable moiety dehydroascorbic acid, and this effect was increased by priming the cells with GM-CSF. Thus, the CSFs act at least at two distinct functional loci to increase cellular vitamin C uptake: conversion of ascorbic acid to dehydroascorbic acid by enhanced oxidation in the pericellular milieu and increased transport of DHA through the facilitative glucose transporters at the cell membrane. These results link the regulated uptake of vitamin C in human host defense cells to the action of CSFs.
ChemInform Abstract: Magnetic Multilayer Structures (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Mistaken Identity: Neosartorya pseudofischeri and Its Anamorph Masquerading as Aspergillus fumigatus (2005)

Invasive fungal infections caused by Neosartorya pseudofischeri S. W. Peterson [anamorph Aspergillus thermomutatus (Paden) S. W. Peterson] are extremely rare. Phenotypically, the anamorphic state of N. pseudofischeri resembles Aspergillus fumigatus, the predominant agent of invasive aspergillosis in immunocompromised hosts. We report the recovery of three clinical isolates of N. pseudofischeri, all initially misidentified by morphological characteristics as A. fumigatus. All three isolates were correctly identified by sequencing portions of the beta-tubulin and the rodlet A genes. Only one of the three isolates produced the confirmatory fruiting bodies and was thus classified as N. pseudofischeri; the other isolates did not produce asci and were therefore identified as A. thermomutatus. All three isolates had higher MICs to voriconazole in vitro compared to A. fumigatus Af293. This report emphasizes that phenotypic identification of filamentous fungi may not identify morphologically similar, but genetically distinct, members of the genus Aspergillus section Fumigati. Accurate identification of these organisms may be clinically meaningful, given their potential differences in antifungal susceptibilities.
Antiglycation, antiplatelets aggregation, cytotoxic and phytotoxic activities of Nepeta suavis (2010)

Nepeta suavis Stapf. (Lamiaceae), one of the ignored species for testing biological activities, was studied. In present research, the Nepeta suavis fractions: chloroform (FC), ethyl acetate (FE) and aqueous (FW) were evaluated for platelet aggregation, antiglycation, cytoxicity, and phytotoxicity. FE showed 65.60% antiglycation activity against the protein glycation while the other fractions showed less than 50% inhibitory potential. The FW inhibited arachidonic acid (AA) and platelet activating factor (acetyl-glyceryl-ether-phosphorylcholine, PAF) induced platelet aggregation. FE showed significant cytotoxicity against brine shrimp larvae with LD50 of 41.3 μg/ml. Phytotoxic studies of FC, FE and FW against Lemna minor showed 77.5-100% inhibitory effects at 1000 μg/ml. However, at lower concentration (10 μg/ml) enhancing effects were observed in FC and FE, as compared to control. FW remained in a uniform pattern of inhibitory effects in all three concentrations (10,100 and 1000 μg/ml). FE showed highest inhibitory activities against formation of glycation, while FW showed significant inhibitory effects against platelet aggregation and Lemna minor. Both of these fractions are recommended for further study to identify and isolate active chemical compounds.