gebhart/patrepeval huggingface dataset:
Rheology and Shear-Induced Alignment of Lamellar Diblock and Triblock Copolymers (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRheology and Shear-Induced Alignment of Lamellar Diblock and Triblock CopolymersBrian L. Riise, Glenn H. Fredrickson, Ronald G. Larson, and Dale S. PearsonCite this: Macromolecules 1995, 28, 23, 7653–7659Publication Date (Print):November 1, 1995Publication History Published online1 May 2002Published inissue 1 November 1995https://pubs.acs.org/doi/10.1021/ma00127a010https://doi.org/10.1021/ma00127a010research-articleACS PublicationsRequest reuse permissionsArticle Views664Altmetric-Citations96LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Endoscopic diagnosis and treatment of esophageal verrucous squamous cell cancer (2012)

Verrucous squamous cell cancer (VSCC) of the esophagus is a variant of squamous cell carcinoma. This rare entity has been described in only a handful of case reports in the literature. We sought to evaluate the endoscopic features, treatment, and outcomes related to esophageal VSCC. The medical records of all patients with esophageal VSCC seen at our institution from January 1995 to December 2010 were reviewed retrospectively. A total of 11 patients (6 men; mean age 66 years [range 57-75 years]) were identified, with a mean follow up of 4 years (range 0.5-10 years) available in nine patients after diagnosis. About half the patients smoked or consumed alcohol on a regular basis. The median time interval from onset of symptoms to diagnosis of esophageal VSCC was 2.5 years (range 1-20 years), with dysphagia being present in all patients. The majority of tumors (8 of 11) exhibited a white, warty, plaque-like appearance with superimposed Candida at endoscopy, which led solely to a diagnosis of Candida esophagitis on initial presentation. The disease was either extensive (n = 5) throughout the esophagus or localized (n = 6) often by tumor nodules or projections, with the lower third of the esophagus being most commonly involved. Initial pinch biopsies were nondiagnostic in eight (73%) of the patients. Six patients underwent esophagectomy; neoadjuvant chemoradiation therapy was provided in two. In patients treated solely with surgery and who had a preoperative endoscopic ultrasound, the latter tended to overestimate staging of the lesion relative to surgical pathologic staging. Two patients were deemed to be poor operative candidates and received only chemoradiation treatment. One patient with a T2N0 tumor by endoscopic ultrasound staging was managed symptomatically with intermittent endoscopic dilation because of significant comorbidities that precluded surgery and oncologic therapy. There has been no evidence for residual or recurrent neoplastic disease in the eight patients who received treatment with surgery and/or chemoradiation therapy. Five of six patients who underwent surgery have required intermittent endoscopic dilation of anastomotic strictures during follow up. One of the two patients who received only chemoradiation therapy has required periodic endoscopic dilation for radiation-induced esophageal stricture. Two of the nine (22%) patients have died of causes unrelated to VSCC or its treatment at last follow up. In conclusion, a high index of suspicion for esophageal VSCC should be raised by the presence of long-standing symptoms coupled with white, warty esophageal lesions seen on endoscopic evaluation. Candida overgrowth can be expected to confound the diagnosis. Despite the long duration of symptoms, surgical resection typically shows relatively low-grade tumors, consistent with the rare propensity of this variant of esophageal squamous cell carcinoma to metastasize.
The Combined Effect of FGFR Inhibition and PD-1 Blockade Promotes Tumor-Intrinsic Induction of Antitumor Immunity (2019)

The success of targeted or immune therapies is often hampered by the emergence of resistance and/or clinical benefit in only a subset of patients. We hypothesized that combining targeted therapy with immune modulation would show enhanced antitumor responses. Here, we explored the combination potential of erdafitinib, a fibroblast growth factor receptor (FGFR) inhibitor under clinical development, with PD-1 blockade in an autochthonous FGFR2<sup>K660N</sup>/p53<sup>mut</sup> lung cancer mouse model. Erdafitinib monotherapy treatment resulted in substantial tumor control but no significant survival benefit. Although anti-PD-1 alone was ineffective, the erdafitinib and anti-PD-1 combination induced significant tumor regression and improved survival. For both erdafitinib monotherapy and combination treatments, tumor control was accompanied by tumor-intrinsic, FGFR pathway inhibition, increased T-cell infiltration, decreased regulatory T cells, and downregulation of PD-L1 expression on tumor cells. These effects were not observed in a KRAS<sup>G12C</sup>-mutant genetically engineered mouse model, which is insensitive to FGFR inhibition, indicating that the immune changes mediated by erdafitinib may be initiated as a consequence of tumor cell killing. A decreased fraction of tumor-associated macrophages also occurred but only in combination-treated tumors. Treatment with erdafitinib decreased T-cell receptor (TCR) clonality, reflecting a broadening of the TCR repertoire induced by tumor cell death, whereas combination with anti-PD-1 led to increased TCR clonality, suggesting a more focused antitumor T-cell response. Our results showed that the combination of erdafitinib and anti-PD-1 drives expansion of T-cell clones and immunologic changes in the tumor microenvironment to support enhanced antitumor immunity and survival.
A Highly Efficient and Stable Blue‐Emitting Cs5Cu3Cl6I2 with a 1D Chain Structure (2020)

In the field of photonics, alkali copper(I) halides attract considerable attention as lead-free emitters. The intrinsic quantum confinement effects originating from low-dimensional electronic structure lead to high photoluminescence quantum yields (PLQYs). Among them, Cs<sub>3</sub> Cu<sub>2</sub> I<sub>5</sub> is the most promising candidate, satisfying both high PLQY and air stability. In this study, a strategy to explore a new material meeting these requirements through the use of the mixed-anions of I<sup>-</sup> and Cl<sup>-</sup> is proposed. The expectation is maintained that the large difference in ionic radii between them likely results in the formation of a novel compound. Consequently, Cs<sub>5</sub> Cu<sub>3</sub> Cl<sub>6</sub> I<sub>2</sub> with a 1D zigzag chain structure is discovered. This material exhibits blue emission (≈462 nm) with a near-unity quantum yield of 95%. An electronic structure calculation reveals that the localized nature of the valence band maximum is crucial in obtaining efficient self-trapped exciton emission. Moreover, the iodine-bridged 1D connectivity significantly enhances the chemical stability of Cs<sub>5</sub> Cu<sub>3</sub> Cl<sub>6</sub> I<sub>2</sub> , compared with the pure chloride phase. The present findings provide a new perspective for developing air-stable alkali copper(I) halides with highly efficient luminescence.
Expose Duration in Visual Acuity Testing. (1999)

視力検査時の視標の提示時間については被検者の反応に応じて延長され、その延長時間の長短は検者の裁量に委ねられているのが実情である。今回我々は、測定時間の差により視力検査の結果がどのように変化するか疾患別に比較検討を行った。その結果、3秒以内で測定した視力と3秒よりも長く時間をかけた視力のLog MARでの差は、正常眼、眼内レンズ挿入眼では差がなかったが、白内障(0.02±0.05)、角膜疾患(0.03±0.08)、糖尿病網膜症(0.08±0.09)、加齢黄斑変性(0.16±0.07)では3秒よりも長く時間をかけた視力が有意に良好であった。よって、視力測定時における視標提示時間は一定とする必要があると思われた。
Role of antibodies, inflammatory markers, and echocardiographic findings in postacute cardiopulmonary symptoms after SARS-CoV-2 infection (2022)

Shortness of breath, chest pain, and palpitations occur as postacute sequelae of COVID-19, but whether symptoms are associated with echocardiographic abnormalities, cardiac biomarkers, or markers of systemic inflammation remains unknown. In a cross-sectional analysis, we assessed symptoms, performed echocardiograms, and measured biomarkers among adults more than 8 weeks after confirmed SARS-CoV-2 infection. We modeled associations between symptoms and baseline characteristics, echocardiographic findings, and biomarkers using logistic regression. We enrolled 102 participants at a median of 7.2 months following COVID-19 onset; 47 individuals reported dyspnea, chest pain, or palpitations. Median age was 52 years, and 41% of participants were women. Female sex, hospitalization, IgG antibody against SARS-CoV-2 receptor binding domain, and C-reactive protein were associated with symptoms. Regarding echocardiographic findings, 4 of 47 participants (9%) with symptoms had pericardial effusions compared with 0 of 55 participants without symptoms; those with effusions had a median of 4 symptoms compared with a median of 1 symptom in those without effusions. There was no strong evidence for a relationship between symptoms and echocardiographic functional parameters or other biomarkers. Among adults more than 8 weeks after SARS-CoV-2 infection, SARS-CoV-2 RBD antibodies, markers of inflammation, and, possibly, pericardial effusions are associated with cardiopulmonary symptoms. Investigation into inflammation as a mechanism underlying postacute sequelae of COVID-19 is warranted.
Unchaining in Design-Space Optimization of Streaming Applications (2013)

Data-streaming applications are frequently pipelined and deployed on hybrid systems to meet performance requirements and resource constraints. With freedom in the design of algorithms and architectures, the search complexity can explode. A popular approach to reducing search complexity is to decompose the search space while preserving optimality. We present a novel decomposition technique called unchaining that partitions the problem such that the resulting sub problems are less complex. Thanks to unchaining, the number of sub problems from the decomposition is linear in the number of chained blocks in the variable-constraint matrix (instead of being their product). Finally, we present a queueing network model and the quantitative search space reduction for a real world implementation of a bio sequence search application called BLASTN.
ChemInform Abstract: An Efficient Approach for Immobilizing the Oxo‐Vanadium Schiff Base onto Polymer Supports Using Staudinger Ligation. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Supplementary Figure S4 from AZD4573 Is a Highly Selective CDK9 Inhibitor That Suppresses MCL-1 and Induces Apoptosis in Hematologic Cancer Cells (2023)

&lt;p&gt;Intermittent dosing of AZD4573 drives regression of hematological tumor xenografts as predicted by a PK/PD/efficacy model.&lt;/p&gt;
Surface modification agents for lithium batteries (2023)

A method includes modifying a surface of an electrode active material including providing a solution or a suspension of a surface modification agent; providing the electrode active material; preparing a slurry of the solution or suspension of the surface modification agent, the electrode active material, a polymeric binder, and a conductive filler; casting the slurry in a metallic current collector; and drying the cast slurry.
CSST: Preventing distribution of unlicensed and rejected ICs by untrusted foundry and assembly (2014)

The globalization of the semiconductor design and fabrication industry (also known as the horizontal business model) has led to many well-documented issues associated with untrusted foundries and assemblies, including IC overproduction, cloning, and the shipping of improperly or insufficiently tested chips. Besides the loss in profits to Intellectual Property (IP) owners, such chips entering the supply chain can have catastrophic consequences for critical applications. We propose a new Secure Split-Test (SST) scheme called the Connecticut SST (CSST) in which the IP owner takes full control over testing. In CSST, each chip and its scan chains are locked during testing, and only the IP owner can interpret the locked test results and unlock passing chips. The new SST can prevent overproduced, defective, and cloned chips from reaching the supply chain. The proposed method considerably simplifies the communication required between the foundry/assembly and the IP owner compared to the original version of the SST. The results demonstrate that our new technique is more secure than the original and has lower communication overheads.
Numerical evaluation of antenna radiation characteristics through an oblique Fibonacci based sampling technique (2009)

Oblique Fibonacci samplings provide a methodology to improve the accuracy of numerical calculations for various antenna performance parameters since they are not parallel to the radiation pattern similarities. Conclusions drawn from the periodic array example illustrate how this method can reduce the amount of time required to evaluate far field radiation characteristics of antennas.
Data from AXL Inhibitor TP-0903 Reduces Metastasis and Therapy Resistance in Pancreatic Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;Pancreatic cancer is the third leading cause of cancer-related deaths in the United States with a 5-year survival less than 5%. Resistance to standard therapy and limited response to immune checkpoint blockade due to the immunosuppressive and stroma-rich microenvironment remain major challenges in the treatment of pancreatic cancer. A key cellular program involved in therapy resistance is epithelial plasticity, which is also associated with invasion, metastasis, and evasion of immune surveillance. The receptor tyrosine kinase AXL is a key driver of tumor cell epithelial plasticity. High expression and activity of AXL is associated with poor prognosis, metastasis, and therapy resistance in multiple types of cancer including pancreatic. Here, we show that an AXL inhibitor (TP-0903), has antitumor and therapy sensitizing effects in preclinical models of pancreatic ductal adenocarcinoma (PDA). We demonstrate that TP-0903 as a single agent or in combination with gemcitabine and/or anti-programmed cell death protein 1 (PD1) antibody has anti-metastatic and anti-tumor effects in PDA tumor bearing mice, leading to increased survival. In addition, gene expression analysis of tumors demonstrated upregulation of pro-inflammatory and immune activation genes in tumors from TP-0903-treated animals compared with the vehicle, indicating pharmacologic inhibition of AXL activation leads to an immunostimulatory microenvironment. This effect was augmented when TP-0903 was combined with gemcitabine and anti-PD1 antibody. These results provide clear rationale for evaluating TP-0903 in the treatment of pancreatic cancer.&lt;/p&gt;&lt;/div&gt;
Phosphorescent OLEDs: Enabling energy‐efficient lighting with improved uniformity and longer lifetime (2011)

Abstract— In this paper, the design criteria for scaling up from small‐area organic light‐emitting‐diode (OLED) pixels to large‐area OLED light panels is described. Particular focus is placed on using phosphorescent OLEDs (PHOLEDs) to maximize panel efficacy and uniformity and minimize operating temperature. Data for a pair of all‐phosphorescent 15 × 15 cm OLED light panels are also presented: Panel 1 has 62‐lm/W efficacy, CRI = 81, CCT = 3180K, and lifetime to LT70 = 18,000 hours at 1000 cd/m 2 and Panel 2 has 58‐lm/W efficacy, CRI = 82, CCT = 2640K, and lifetime to LT70 = 30,000 hours at 1000 cd/m 2 . Operating at a 3000 cd/m 2 (7740 lm/m 2 ), Panel 2 has 49‐lm/W efficacy with lifetime to LT70 = 4000 hours. Excellent panel lifetime is enabled by a stable light‐blue phosphorescent materials system and by the use of efficient phosphorescent emitters that ensure very low panel temperature without any additional thermal management.
Supplementary Figures 1-10 from Targeting C4-Demethylating Genes in the Cholesterol Pathway Sensitizes Cancer Cells to EGF Receptor Inhibitors via Increased EGF Receptor Degradation (2023)

&lt;p&gt;PDF file - 1.2MB, Fig. S1. Validation of the sterol pathway targeting siRNA. Fig. S2. Silencing of SC4MOL increased erlotinib-induced apoptosis. Fig. S3. Metabolic effects of SC4MOL silencing and sterols supplementation. Fig. S4. Sterol pathway interactions. Fig. S5. Effects of SC4MOL silencing on EGFR synthesis and I-125 EGF internalization and degradation. Fig. S6. Effects of sterol pathway genes silencing on EGFR endosomal traffic. Fig. S7. Effects of SC4MOL silencing on EGFR ubiquitin conjugation and accumulation in late endosomes. Fig. S8. Supporting data for Figure 5. Fig. S9. Supporting data for Figure 7A. Fig. S10. Analysis of NSDHL expression in malignant and benign epithelial tissues&lt;/p&gt;
Visualisation for informed decision making; from code to components (2002)

The problem of trying to view and comprehend large amounts of data is a well-known one. A specialised variant of this problem is the visualisation of software code and components for the purposes of understanding, decision-making, reuse and even integration. In particular the visualisation of software components, at a much higher level than source code, has received very little research. Visualisation is a powerful tool in situations such as this. This paper presents the application of real world metaphor based visualisations that address this problem. The application of visualisation to selecting software components is especially novel. It seeks to decrease the effort required by system integrators when locating suitable components in what is an increasingly crowded marketplace. Accurate information and understanding are vital if correct and informed decisions and judgements are to be made.
Assessment of gauze-based negative pressure wound therapy in the split-thickness skin graft clinical pathway-an observational study. (2011)

Gauze-based NPWT appears to be an effective addition to the care and management of wounds intended for definitive closure by STSG.
Techno-economic assessment of establishment of wind farms in different provinces of Saudi Arabia to mitigate future energy challenges (2018)

In the present study, the techno-economic feasibility of development of 15 MW wind power plants (wind farms) in the Kingdom of Saudi Arabia has been investigated by analyzing long-term wind speed data. To achieve this aim, two geographically distinct sites covering different non-coastal locations of the Kingdom of Saudi Arabia have been selected. Long-term data indicates that the yearly average wind speed of Kingdom of Saudi Arabia varies from 3.0-4.5 m/s at 10 m height. The wind farms simulated consist of different combinations of 600 kW commercial wind machines (50 m hub-height). The NREL?s (HOMER Energy?s) HOMER software has been employed to perform the analysis. The study presents the monthly variations of wind speed, cumulative frequency distribution profiles of wind speed, monthly and yearly amount of energy generated from the proposed 15 MW wind farms (50 m hub-height) at different non-coastal locations of Kingdom of Saudi Arabia, cost of generating energy ($/kWh), capacity factor (%), etc. The cumulative frequency distribution indicates that the wind speeds are less than 3 m/s for 48% and 59% of the time during the year at Badanah (Northern province) and Khamis-Mashayt (Southern province), respectively. This implies that wind electric conversion systems or wind farms will not produce energy for 48% of the time during the year at Badanah and for 59% at Khamis-Mashayt. The annual energy produced by 15 MW wind farms (50 m hub-height) has been found to be 18778 and 11314 MWh at Northern and Southern provinces, respectively. The cost of wind-based electricity by using 600 kW (50 m hub-height) commercial wind electric conversion systems has been found to be 0.0612 and 0.1016 US$/kWh for Badanah and Khamis-Mushayt, respectively. Also, the capacity factor of the wind-based power plant has been found to vary from 9 to 15% for the considered locations.
Supplementary Material for: Novel Adenovirus Vectors ‘Capsid-Displaying’ a Human Complement Inhibitor (2010)

Adenovirus (Ad) vectors are currently the most commonly utilized gene transfer vectors in humans worldwide. Unfortunately, upon contact with the circulatory system, Ads induce several, innate, complement-dependent toxicities that limit the full potential for Ad-based gene transfer applications. Therefore, we have constructed several novel Ad5-based vectors, ‘capsid-displaying’ as fiber or pIX fusion proteins, a complement-regulatory peptide (COMPinh). These novel Ads dramatically minimize Ad-dependent activation of the human and non-human primate complement systems, as determined by several assays. In summary, our work has shown that a novel COMPinh-displaying Ad5 has the potential for broadening the safe use of Ad vectors in future human applications.
Fluorescent Imaging for In Situ Measurement of Drug Target Engagement and Cell Signaling Pathways. (2020)

Successful cancer treatment continues to elude modern medicine and its arsenal of therapeutic strategies. Therapy resistance is driven by significant tumor heterogeneity, complex interactions between malignant, microenvironmental and immune cells and cross talk between signaling pathways. Advances in molecular characterization technologies such as next generation sequencing have helped unravel this network of interactions and identify druggable therapeutic targets. Tyrosine kinase inhibitors (TKI) are a class of drugs seeking to inhibit signaling pathways critical to sustaining proliferative signaling, resisting cell death, and the other hallmarks of cancer. While tumors may initially respond to TKI therapy, disease progression is near universal due to mechanisms of acquired resistance largely involving cellular signaling pathway reprogramming. With the ultimate goal of improved TKI therapeutic efficacy our group has developed intracellular paired agent imaging (iPAI) to quantify drug target interactions and oligonucleotide conjugated antibody (Ab-oligo) cyclic immunofluorescence (cycIF) imaging to characterize perturbed signaling pathways in response to therapy. iPAI uses spectrally distinct, fluorescently labeled targeted and untargeted drug derivatives, correcting for non-specific drug distribution and facilitating quantitative assessment of the drug binding before and after therapy. Ab-oligo cycIF exploits <i>in situ</i> hybridization of complementary oligonucleotides for biomarker labeling while oligonucleotide modifications facilitate signal removal for sequential rounds of fluorescent tagging and imaging. Ab-oligo CycIF is capable of generating extreme multi-parametric images for quantifying total and phosphorylated protein expression to quantify protein activation, expression, and spatial distribution. Together iPAI and Ab-oligo cycIF can be applied to interrogate drug uptake and target binding as well as changes to heterogenous cell populations within tumors that drive variable therapeutic responses in patients.