gebhart/patrepeval huggingface dataset:
The Hidden Pandemic of COVID-19-Induced Organizing Pneumonia (2022)

Since the beginning of the COVID-19 pandemic, clinical, radiological, and histopathological studies have provided evidence that organizing pneumonia is a possible consequence of the SARS-CoV2 infection. This post-COVID-19 organizing pneumonia (PCOP) causes persisting dyspnea, impaired pulmonary function, and produces radiological abnormalities for at least 5 weeks after onset of symptoms. While most patients with PCOP recover within a year after acute COVID-19, 5-25% of cases need specialized treatment. However, despite substantial resources allocated worldwide to finding a solution to this problem, there are no approved treatments for PCOP. Oral corticosteroids produce a therapeutic response in a majority of such PCOP patients, but their application is limited by the anticipated high-relapse frequency and the risk of severe adverse effects. Herein, we conduct a systematic comparison of the epidemiology, pathogenesis, and clinical presentation of the organizing pneumonias caused by COVID-19 as well as other viral infections. We also use the clinical efficacy of corticosteroids in other postinfection OPs (PIOPs) to predict the therapeutic response in the treatment of PCOP. Finally, we discuss the potential application of a candidate anti-inflammatory and antifibrotic therapy for the treatment of PCOP based on the analysis of the latest clinical trials data.
EventThread: Visual Summarization and Stage Analysis of Event Sequence Data (2017)

Event sequence data such as electronic health records, a person's academic records, or car service records, are ordered series of events which have occurred over a period of time. Analyzing collections of event sequences can reveal common or semantically important sequential patterns. For example, event sequence analysis might reveal frequently used care plans for treating a disease, typical publishing patterns of professors, and the patterns of service that result in a well-maintained car. It is challenging, however, to visually explore large numbers of event sequences, or sequences with large numbers of event types. Existing methods focus on extracting explicitly matching patterns of events using statistical analysis to create stages of event progression over time. However, these methods fail to capture latent clusters of similar but not identical evolutions of event sequences. In this paper, we introduce a novel visualization system named EventThread which clusters event sequences into threads based on tensor analysis and visualizes the latent stage categories and evolution patterns by interactively grouping the threads by similarity into time-specific clusters. We demonstrate the effectiveness of EventThread through usage scenarios in three different application domains and via interviews with an expert user.
Strain Gage Ramifications on Mistuning in As-Manufactured Models and Experimental Testing (2019)

Abstract Blade-mounted strain gages are vital during rig and engine development to ensure safe engine operation. However, they also enable a change in dynamics of integrally bladed rotors (IBRs). State-of-the-art IBR dynamic response predictions are accomplished using as-manufactured models (AMMs) generated via optical topography measurements and mesh morphing. Two AMM finite element models (FEMs) are created of a 20-bladed IBR. One FEM has no strain gages present, where the second FEM includes strain gages on six blades. Traditionally, strain gages and lead wires are treated as the same material property as the IBR itself. It will be shown that the inclusion of strain gages in AMM's using this method changes the IBR's predicted mistuning. An alternative AMM approach is developed that changes the material properties of the finite elements attributed to the strain gages. The predicted mistuning for each AMM is accomplished using the fundamental mistuning model identification (FMM ID), where the predicted mistuning will be compared to both traveling wave excitation (TWE) experiments and a rotating, single stage compressor rig. Findings show mistuning predictions of the nonstrain gaged AMM compare far better to the experiments compared to the inclusion of the strain gages in the AMM. Additionally, altering material properties of the strain gages in the AMM improve mistuning prediction compared to treating the strain gages as the parent IBR material. Therefore, AMM should be acquired using clean, nonstrain gaged rotors or the material properties of strain gaged elements need to be altered to more accurately model the component.
Steerable interfaces for pervasive computing spaces (2004)

This paper introduces a new class of interactive interfaces that can be moved around to appear on ordinary objects and surfaces anywhere in a space. By dynamically adapting the form, function, and location of an interface to suit the context of the user, such steerable interfaces have the potential to offer radically new and powerful styles of interaction in intelligent pervasive computing spaces. We propose defining characteristics of steerable interfaces and present the first steerable interface system that combines projection, gesture recognition, user tracking, environment modeling and geometric reasoning components within a system architecture. Our work suggests that there is great promise and rich potential for further research on steerable interfaces.
Selectively targeting the DNA-binding domain of the androgen receptor as a prospective therapy for prostate cancer. (2015)

VOLUME 289 (2014) PAGES 26417–26429 A symbol was omitted to designate that Drs. Artem Cherkasov and Paul S. Rennie are equal senior authors.
Artificial Intelligence : from Research to Application ; the Upper-Rhine Artificial Intelligence Symposium (UR-AI 2019) (2019)

The TriRhenaTech alliance universities and their partners presented their competences in the field of artificial intelligence and their cross-border cooperations with the industry at the tri-national conference 'Artificial Intelligence : from Research to Application' on March 13th, 2019 in Offenburg. The TriRhenaTech alliance is a network of universities in the Upper Rhine Trinational Metropolitan Region comprising of the German universities of applied sciences in Furtwangen, Kaiserslautern, Karlsruhe, and Offenburg, the Baden-Wuerttemberg Cooperative State University Loerrach, the French university network Alsace Tech (comprised of 14 'grandes écoles' in the fields of engineering, architecture and management) and the University of Applied Sciences and Arts Northwestern Switzerland. The alliance's common goal is to reinforce the transfer of knowledge, research, and technology, as well as the cross-border mobility of students.
Roles of Solute C and Grain Boundary in Strain Aging Behaviour of Fine-grained Ultra-low Carbon Steel Sheets (2017)

The roles of solute C and the grain boundary in the strain aging phenomenon of polycrystalline ferritic steel were investigated using Nb-bearing ULC steel sheets with a relatively low solute C content of 1–3 ppm and ferrite grain sizes of 9.5 µm and 183 µm at aging temperatures from 70 to 400°C. The steels exhibited two definite hardening stages. The 1st hardening stage appeared in both fine- and coarse-grained specimens, in which the increase in YP (ΔYP) became saturated at around 30 MPa. From the apparent activation energy and hardening kinetics, the hardening mechanism was assumed to be dislocation pinning by solute C atoms. The 2nd hardening stage, significantly appeared in fine-grained specimens accompanying a large increase in the Hall-Petch coefficient; ΔYP was quite large, reaching 90 MPa. Fine precipitates were not detected in aged specimens observed by TEM and 3DAP. Segregation of solute C to the grain boundaries and diffusion of Fe atoms in the grain boundaries were proposed as possible mechanisms of this 2nd hardening. Grain-boundary hardening was assumed to be one of the hardening mechanisms in the strain aging in polycrystalline ferritic steel.
Novel Modulation of Drug Delivery Using Binary Zinc-Alginate-Pectinate Polyspheres for Zero-Order Kinetics Over Several Days: Experimental Design Strategy to Elucidate the Crosslinking Mechanism (2005)

A Box-Behnken design was applied to mathematically establish whether different degrees of crosslinking were induced by Zn2+ and Ca2+ ions in polyspheres composed of alginate and/or pectin, and the model drug ibuprofen. Based on their different crystal structures and coordination numbers, a theoretical model was proposed demonstrating that Zn2+ ions preferentially crosslink alginate and pectin. In addition, the lower coordination number of Zn2+ (4-6) would significantly retard hydration of both polymers, as opposed to Ca2+ (7-9). The responses studied for 28 statistically derived polyspheres included drug encapsulation efficiency, physicomechanical behavior, and in vitro drug release potential. Single-tailed Student's t-tests on data generated for the encapsulation efficiencies, primary facture values, and rupture energies indicated that Zn2+ was statistically superior (p<0.05) in crosslinking alginate and pectin. Further textural analysis revealed a good correlation between the Brinell hardness number and fracture load, while an inverse relationship was found for matrix tensile strength. Viscosity studies demonstrated different in situ crosslinking thresholds for Zn2+. The Durbin-Watson statistic and correlation coefficient revealed that the quadratic regression function was highly accurate in predicting the responses. Using a generalized reduced gradient algorithm on dissolution values obtained after 2 hours (t2h) provided optimized solutions for achieving zero-order release extending from 2 hours to 7 days. Mathematical simulations projected drug release from 25 to 50 days.
SUN-260 REFERENCE RANGES FOR LEAN AND FAT TISSUE INDEX(LTI, FTI) IN A LARGE ASIAN POPULATION (2019)

Bioimpedance analysis has become a widely used technology to assess body composition in health and disease. While most devices on the market use a single frequency, multifrequency devices have advantages in extremes of body composition. The BCM-Body Composition Monitor combines spectroscopy with the Chamney 3-compartment model (Chamney et al, AJCN 2007) to determine body composition independent of fluid status, and is thereby the only device suitable in patients with altered hydration status. While reference ranges for lean and fat tissue index (LTI, FTI) have been long available for Caucasians, no such data has yet been collected in a large and diverse Asian population.
Epigenetic Modulation to Enable Antigen-specific T-cell Therapy of Colorectal Cancer (2012)

Development of specific immunotherapy for colorectal cancer (CRC) will require identification of antigens selectively or exclusively expressed on CRC cells and strategies to induce and enhance immune responses against these antigenic targets. Cancer-testis (C-T) antigens are proving to be excellent targets for immunotherapy of solid tumors such as melanoma, but their clinical utility for treatment of CRC has to date been limited by their infrequent expression in CRC cells. Here we report that the hypomethylating agent 5-aza-2'-deoxycytidine (DAC) induces expression of NY-ESO-1 and other C-T genes in CRC cells both in vitro and in vivo in a dose-dependent manner but has negligible effects on the expression of C-T genes in normal nontransformed cells such as fibroblasts. The induction by DAC of NY-ESO-1 expression in CRC cells persists over 100 days after DAC exposure and is associated with increased levels of NY-ESO-1 protein. CRC cells exposed to DAC at concentrations that can be readily achieved in vivo are rendered susceptible to major histocompatibility complex-restricted recognition by CD8 NY-ESO-1-specific T cells. We also demonstrate that retroviral transduction of polyclonal peripheral blood T cells from a metastatic CRC patient with the T-cell receptor α-chain and β-chain genes encoding a human leukocyte antigen-A2-restricted, NY-ESO-1157-165-specific T-cell receptor can be used to generate both CD8 and CD4 NY-ESO-1157-165-specific T cells that selectively recognize DAC-treated CRC but not nontransformed cells. Collectively, these results suggest that the combination of epigenetic modulation and adoptive transfer of genetically engineered T lymphocytes may enable specific immunotherapy for CRC.
Subject Index Vol. 220, 2006 (2006)

assisted 307 Drainage site 83 Droperidol 242 Dry eye 141
GROUP MEMBERSHIP IN THE EPIDEMIC STYLE (1992)

Existing group membership mechanisms provide consistent views of membership changes. However, they require heavyweight synchronous multicast protocols. We present a new lightweight group membership mechanism that allows temporary inconsistencies in membership views. This mechanism uses epidemic communication techniques to ensure that all group members eventually converge to a consistent view of the membership. Members can join or leave groups, and we show that the mechanism is resilient tokn?2 members failing by crashing, wherenis the number of members in the group.
Short circuit behavior of the Bi-mode Insulated Gate Transistor (BIGT) (2013)

The BIGT is a Reverse Conducting IGBT device which combines functionality of a high power IGBT and fast diode on a single chip. In this paper, an investigation of the IGBT mode short circuit performance of the BIGT is carried out. The behavior of the BIGT under IGBT mode short circuit conditions is illustrated by measurements on a 3.3kV 1500A HiPak1 module and then supported by circuit and detailed device physics simulations. The short circuit conditions of type II and type III are discussed, with the variations introduced due to the gate control of the BIGT when operated in reverse conducting mode. Comparison to standard IGBTs with Soft-Punch-Through (SPT) technology in a HiPak2 module is also provided.
A phase I, first-in-human, open label, dose-escalation and cohort expansion study of MGD019, a bispecific DART protein binding PD-1 and CTLA-4 in patients with unresectable or metastatic neoplasms. (2019)

TPS2661 Background: Immune checkpoint molecules, including CTLA-4 and PD-1, attenuate the duration and strength of adaptive immune responses to limit immune-mediated tissue damage. Tumors may inhibit cellular immune activation by expressing ligands that bind checkpoint molecules and inhibit T-cell function in the tumor microenvironment. Blockade of these inhibitory pathways is the primary mechanism of action of several novel cancer immunotherapy agents. Combined blockade of PD-1 and CTLA-4 with two checkpoint inhibitors, ipilimumab and nivolumab, increases antitumor activity beyond either single agent alone in patients with metastatic melanoma or other malignancies. MGD019, a novel bispecific molecule that co-engages and coordinately inhibits both PD-1 and CTLA-4 signaling, was developed to potentially improve antitumor activity and/or safety relative to the monoclonal antibody combination. MGD019 is an Fc-bearing tetravalent DART molecule (bivalent for each antigen) that can independently block either checkpoint molecule, with preferential co-blockade in cells co-expressing both molecules demonstrated in vitro. It is hypothesized that MGD019 might be clinically active in either checkpoint naïve or checkpoint experienced patients after prior PD-1/PD-L1 inhibitors. Methods: This Phase 1 study will characterize safety, dose limiting toxicities, and maximum tolerated dose (MTD)/maximum administered dose (MAD) of MGD019. Dose Escalation will enroll patients with advanced solid tumors of any histology in sequential escalating doses in cohorts of 3 to 9 patients in a 3+3+3 design. Once the MTD/MAD is reached, a Cohort Expansion phase will characterize safety and initial antitumor activity per RECIST v1.1 and irRECIST in patients with specific tumor types anticipated to be sensitive to dual checkpoint blockade. Additional endpoints include pharmacokinetics; immunogenicity; impact of MGD019 on various measures of immune-regulatory effects in peripheral blood and biopsy specimens; and relationship between antitumor activity and gene profiles, tumor mutational burden, and PD-1, PD-L1, and CTLA-4 expression on tumor cells and immune cell infiltrates within biopsy specimens. Patients will be followed for survival approximately every 3 months for 2 years. Clinical trial information: NCT03761017.
Allosteric role of the citrate synthase homology domain of ATP citrate lyase (2023)

ATP citrate lyase (ACLY) is the predominant nucleocytosolic source of acetyl-CoA and is aberrantly regulated in many diseases making it an attractive therapeutic target. Structural studies of ACLY reveal a central homotetrameric core citrate synthase homology (CSH) module flanked by acyl-CoA synthetase homology (ASH) domains, with ATP and citrate binding the ASH domain and CoA binding the ASH-CSH interface to produce acetyl-CoA and oxaloacetate products. The specific catalytic role of the CSH module and an essential D1026A residue contained within it has been a matter of debate. Here, we report biochemical and structural analysis of an ACLY-D1026A mutant demonstrating that this mutant traps a (3S)-citryl-CoA intermediate in the ASH domain in a configuration that is incompatible with the formation of acetyl-CoA, is able to convert acetyl-CoA and OAA to (3S)-citryl-CoA in the ASH domain, and can load CoA and unload acetyl-CoA in the CSH module. Together, this data support an allosteric role for the CSH module in ACLY catalysis.
Challenges in polarization ray tracing (2010)

New polarization methods allow the ray tracing simulation of polarization critical components, including multilayer biaxial films, anisotropic and gyrotropic crystals, electro-optical, and magneto-optical materials bring many new challenges.
Autonomous, Hands‐Free Shape Memory in Glassy, Liquid Crystalline Polymer Networks (2012)

Repeatedly forming temporary shapes can be a limitation to the employment of shape memory polymers. This work utilizes glassy, liquid crystal polymer networks to spontaneously form 3D shapes that are independent of a user. These shapes are autonomously fixed with rapid temperature cycling.
Multi-Stressor's Effects on Contamination and Toxicity in French Streams Using Ecotoxicological Indicators based on Caged Gammarids (2019)

Many freshwater ecological studies focused on the effects of environmental stressors induced by anthropogenic activities such as land use or alteration of hydromorphology and physico-chemistry conditions. While it is recognized as a potential major driver of ecological alteration, ecotoxicological stress is yet rarely explicitly considered. By combining ecological monitoring and field ecotoxicological approaches, the purpose of this research is to focus on the origin and levels of bioavailable contamination as well as toxicity in freshwater ecosystems taking into account various stream typologies and unraveling the relative impacts of other stressors on these two variables. Datasets of active biomonitoring at the French national scale were established, with 333 sites being investigated from 2009 to 2018. Bioavailable contamination (metallic and persistent organic substances) in freshwater ecosystems was assessed by bioaccumulation measurement in caged Gammarids. Stream toxicity was based on mortality and feeding activity of exposed organisms. \nFor each site, integrated indicators of contamination and toxicity were computed with weighting chemical and biological measurements by national reference values. The link between environmental stressors and ecotoxicological indicators was modeled via Structural Equation Modeling. The model was adjusted according to the source of pollution and is reliable with the consideration of multi-scale and multi-stressor concepts. It enables to understand the role of driving forces (land use, hydromorphology, etc.) and their impact on the two outputs (contamination and toxicity). Its application improves the understanding of contamination and toxicity levels. It can also provide a prediction of risks of contamination and/or toxicity in aquatic environments.
Understanding and controlling bias-temperature instability in SiC metal-oxide-semiconductor devices induced by unusual generation of mobile ions (2013)

Unusual behavior of bias-temperature instabilities in SiC metal-oxide-semiconductor (MOS) devices is studied. Electrical measurements of SiC-MOS capacitors are used to investigate details of self-generated mobile ions in thermal oxides on 4H-SiC(0001) substrates, such as their polarity, density, distribution, and impact on interface properties. It is found that positive bias-temperature stress (BTS) accumulates self-generated positive mobile ions at the bottom SiO2/SiC interface with an areal density of several 1012 cm−2, and that they induce additional electron trap formation at the interface. Using this knowledge, we demonstrate effective removal of the positive mobile ions with a combination of negative BTS and subsequent etching of the oxide surface.
Vessel wall imaging with advanced flow suppression in the characterization of intracranial aneurysms following flow diversion with Pipeline embolization device (2022)

Advanced VWI produces excellent depiction of FD-treated aneurysms, with robust evaluation of the parent vessel and aneurysm wall to an extent not achievable with conventional MRI/MRA. Gadolinium enhancement may, however, continue even after enduring catheter angiographic occlusion, confounding interpretation, and requiring cognizance of this potentially prolonged effect in such patients.
IMD HUMS rotor track and balance techniques (2004)

The purpose of this paper is to discuss the inner workings of the Integrated Mechanical Diagnostics Health and Usage Management Systems (IMD HUMS) Rotor Track and Balance (RTB) algorithm and its performance. The algorithm can perform solutions in two modes Minimum Vibration (MV) or Minimum Adjustment (MA) with or without track data. The system is totally configurable and can be adapted to run on practically any helicopter. The IMD HUMS system will balance a healthy helicopter in no more than two maintenance actions and typically only one is required. With the multiple modes available to fit the maintainers immediate needs and typical balancing performance of only one maintenance action the helicopter down time will be less and the operational costs reduced. 12
Consensus Document: Antithrombotic therapy in patients with atrial fibrillation undergoing coronary stenting (2011)

The optimal regimen of the anticoagulant and antiplatelet therapies in patients with atrial fibrillation who have had a coronary stent is unclear. It is well recognised that "triple therapy" with aspirin, clopidogrel, and warfarin is associated with an increased risk of bleeding. National guidelines have not made specific recommendations given the lack of adequate data. In choosing the best antithrombotic options for a patient, consideration needs to be given to the risks of stroke, stent thrombosis and major bleeding. This document describes these risks, provides specific recommendations concerning vascular access, stent choice, concomitant use of proton-pump inhibitors and the use and duration of triple therapy following stent placement based upon the risk assessment.
ChemInform Abstract: Ring‐Closing Metathesis of Functionalized Acetylene Derivatives: A New Entry into Cycloalkynes. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.