gebhart/patrepeval huggingface dataset:
Zfp36l3, a Rodent X Chromosome Gene Encoding a Placenta-Specific Member of the Tristetraprolin Family of CCCH Tandem Zinc Finger Proteins (2005)

Members of the tristetraprolin (TTP) family of CCCH tandem zinc finger (TZF) proteins can bind directly to AU-rich elements (ARE) in mRNA, causing deadenylation and destabilization of the transcripts to which they bind. We describe here a novel fourth mammalian member of the TTP protein family, designated ZFP36L3, which could also bind directly to ARE-containing RNAs and could promote the deadenylation and degradation of ARE-containing target RNAs. Zfp36l3 transcript expression was detected only in placenta and extraembryonic tissues in the mouse. It was expressed throughout development in the placenta and was particularly highly expressed in the cells of the labyrinthine layer of the trophoblastic placenta. Unlike the other family members, the expression of a ZFP36L3-green fluorescent protein fusion protein was entirely cytoplasmic when expressed in 293 cells, even in the presence of the CRM1-dependent nuclear export inhibitor leptomycin B. Zfp36l3 was located on the mouse X chromosome; a similar predicted gene was present on the rat X chromosome, but there was no evidence for a similar gene in humans. ZFP36L3 may thus be a rodent-specific or even murine-specific member of the TTP protein family. Its presumed role in placental physiology may be unique to rodents or murine rodents, but this role may be subsumed by other family members in nonrodents.
An Accurate Instruction-Level Energy Consumption Model for Embedded RISC Processors (2001)

Energy consumption of software is becoming an increasingly important issue in designing mobile embedded systems where batteries are used as the main power source. As a consequence, recently, a number of promising techniques have been proposed to optimize software for reduced energy consumption. Such low-power software techniques require an energy consumption model that can be used to estimate or predict the energy consumed by software. We propose a technique to derive an accurate energy consumption model at the instruction level, combining an empirical method and a statistical analysis technique. The result of the proposed approach is given by a model equation that characterizes energy behavior of software based on the properties of the instructions. Experimental results show that the model equation can accurately estimate the energy consumption of random instruction sequences, with an average error of 2.5%
Image-based Finite Element Evaluation of Porosity Reduction in Compression Process of Aluminum Alloy Die Castings (2007)

In the die casting process, a formation of porosity is unavoidable. The porosity influences the mechanical properties and air leakage resistance of the products. We have investigated optimum manner of post compression process of ADC 12 aluminum alloy die castings to reduce inside porosity size. The reduction efficiency was affected by initial size and distribution of the porosity. In this study, two-dimensional imaged-based finite element analysis was conducted to find the optimum manner of post compression process considering porosity size and porosity distribution inside die castings. The mesh for finite element analyses was generated from X-ray CT images of the ADC 12 aluminum alloy die casting specimen. Comparing the deformation of porosity of numerical result and experimental result, we proved that the two-dimensional image-based finite element method works well to estimate the effect of the post compression process. We investigated the porosity reduction efficiency of biaxial and triaxial compression by using the same two-dimensional image-based finite element mesh.
Friction Stir Welding Development at NASA-Marshall Space Flight Center (2001)

This paper presents an overview of friction stir welding (FSW) process development and applications at Marshall Space Flight Center (MSFC). FSW process development started as a laboratory curiosity but soon found support from many users. The FSW process advanced very quickly and has found many applications both within and outside the aerospace industry. It is currently being adapted for joining key elements of the Space Shuttle External Tank for improved producibility and reliability. FSW process modeling is done to better understand and improve the process. Special tools have been developed to weld variable thickness materials including thin and thick materials. FSW is now being applied to higher temperature materials such as copper and to advanced materials such as metal matrix composites. FSW technology is being successfully transferred from MSFC laboratory to shop floors of many commercial companies.
Transitory Change of Bacterial Community Structure in Hot Water Biofilm: Effects of Anti‐Legionella Treatments (2018)

Hot water networks are known to harbor pathogenic bacteria like Legionella . The present work aims to study bacterial community structure surrounding Legionella in biofilm before (T0) and after (72 h) two heat shocks (HS1 and HS2) followed by chemical treatment (C2). Phylogenetic study shows the dominance of Proteobacteria phylum with three classes ( Alphaproteobacteria , Betaproteobacteria and Gammaproteobacteria ) except for 72h‐HS2 where Bacteriodetes dominated the phyla (49%.) Three phylotypes dominate the total of sequences; Aquabacterium (22.8%), Novosphingobium (15%) and Burkholderiales (9.6%) of which none is detected in the biofilm after HS2 and the majority of sequences belong to new unclassified bacteria (60.7%). Aquabacterium and Novosphingobium are quickly detected again at T0 before C2. Sequences possibly close to opportunistic bacteria (11.7%; Legionella rubrilucens , L. anisa , Caulobacter , Leptospira , Burkholderiales, and Mycobacterium ) are no more detectable after treatments indicating their disappearance or their minor presence compared to other bacteria. Principal component analysis shows a distinct bacterial community structure after HS2. This structure is back to the initial state after C2. The current findings underline the incomplete and transitory change of bacterial community structure in hot water biofilm by heat shock and chemical treatments. Therefore, Legionella eradication requires complete biofilm elimination.
Stimuli-Responsive Boron-Based Materials in Drug Delivery (2023)

Drug delivery systems, which use components at the nanoscale level as diagnostic tools or to release therapeutic drugs to particular target areas in a regulated manner, are a fast-evolving field of science. The active pharmaceutical substance can be released via the drug delivery system to produce the desired therapeutic effect. The poor bioavailability and irregular plasma drug levels of conventional drug delivery systems (tablets, capsules, syrups, etc.) prevent them from achieving sustained delivery. The entire therapy process may be ineffective without a reliable delivery system. To achieve optimal safety and effectiveness, the drug must also be administered at a precision-controlled rate and the targeted spot. The issues with traditional drug delivery are overcome by the development of stimuli-responsive controlled drug release. Over the past decades, regulated drug delivery has evolved considerably, progressing from large- and nanoscale to smart-controlled drug delivery for several diseases. The current review provides an updated overview of recent developments in the field of stimuli-responsive boron-based materials in drug delivery for various diseases. Boron-containing compounds such as boron nitride, boronic acid, and boron dipyrromethene have been developed as a moving field of research in drug delivery. Due to their ability to achieve precise control over drug release through the response to particular stimuli (pH, light, glutathione, glucose or temperature), stimuli-responsive nanoscale drug delivery systems are attracting a lot of attention. The potential of developing their capabilities to a wide range of nanoscale systems, such as nanoparticles, nanosheets/nanospheres, nanotubes, nanocarriers, microneedles, nanocapsules, hydrogel, nanoassembly, etc., is also addressed and examined. This review also provides overall design principles to include stimuli-responsive boron nanomaterial-based drug delivery systems, which might inspire new concepts and applications.
Supplementary Figure 4 from Transient Antiangiogenic Treatment Improves Delivery of Cytotoxic Compounds and Therapeutic Outcome in Lung Cancer (2023)

&lt;p&gt;PDF file - 1341KB, Pericyte coverage and tumor cell proliferation.&lt;/p&gt;
Long range rapidity correlations and jet production in high energy nuclear collisions (2009)

The STAR Collaboration at the Relativistic Heavy Ion Collider presents a systematic study of high-transversemomentum charged-di-hadron correlations at small azimuthal pair separation in d + Au and central Au + Au collisions at s NN = 200 GeV. Significant correlated yield for pairs with large longitudinal separation is observed in central Au + Au collisions, in contrast to d +
Cellular Engineering of HSV-tk Transduced, Expanded T Lymphocytes for Graft-versus-Host Disease Management (2003)

Engineering donor T lymphocytes with inducible 'suicide genes', such as herpes simplex virus thymidine kinase, has potential to improve safety and efficacy in allogeneic transplantation by facilitating management of graft-versus-host disease. Elective administration of a relatively nontoxic pro-drug would induce in vivo negative selection of engineered lymphocytes specifically, sparing other donor hematopoietic cells. The engineered cells must retain immunologic function, and undergo negative selection in response to clinically attainable plasma concentrations of pro-drug. The cell engineering process itself, typically involving activation, transduction, ex vivo expansion, and selection, must produce clinically useful numbers of genetically modified cells at high purity. We discuss development of a cellular engineering manufacturing process that yields transduced, expanded T lymphocytes meeting these requirements.
Correction: Association of Promoter Methylation of VGF and PGP9.5 with Ovarian Cancer Progression (2013)

Purpose: To elucidate the role of biological and clinical impact of aberrant promoter hypermethylation (PH) in ovarian cancer (OC).Experimental Design: PH of PGP9.5, HIC1, AIM1, APC, PAK3, MGMT, KIF1A, CCNA1, ESR1, SSBP2, GSTP1, FKBP4 and VGF were assessed by quantitative methylation specific PCR (QMSP) in a training set.We selected two genes (VGF and PGP9.5) for further QMSP analysis in a larger independent validation (IV) set with available clinical data.Biologic relevance of VGF gene was also evaluated.Results: PH frequency for PGP9.5 and VGF were 85% (316/372) and 43% (158/366) respectively in the IV set of samples while no PH was observed in controls.In 372 OC cases with available follow up, PGP9.5 and VGF PH were correlated with better patient survival [Hazard Ratios (HR) for overall survival (OS) were 0.59 (95% Confidence Intervals (CI) = 0.42-0.84,p = 0.004), and 0.73 (95%CI = 0.55-0.97,p = 0.028) respectively, and for disease specific survival (DSS) were 0.57 (95%CI 0.39-0.82,p = 0.003) and 0.72 (95%CI 0.54-0.96,p = 0.027).In multivariate analysis, VGF PH remained an independent prognostic factor for OS (HR 0.61, 95%CI 0.43-0.86,p,0.005) and DSS (HR 0.58, 95%CI 0.41-0.83,p,0.003).Furthermore, PGP9.5 PH was significantly correlated with lower grade, early stage tumors, and with absence of residual disease.Forced expression of VGF in OC cell lines inhibited cell growth. Conclusions:Our results indicate that VGF and PGP9.5 PH are potential biomarkers for ovarian carcinoma.Confirmatory cohorts with longitudinal follow-up are required in future studies to define the clinical impact of VGF and PGP9.5 PH before clinical application.
Abstract 17408: Left Ventricle Internal Dimension in Diastole Strongly Predicts Long-term Survival Following Continuous Flow Left Ventricular Assist Device Implantation (2014)

Introduction: Left ventricular assist devices (LVADs) are seldom implanted in small hearts, determined by left ventricle internal diameter in diastole (LVIDD), to avoid suction events thought to impact flows, arrhythmias and LVAD function. No published evidence has confirmed this theory. Hypothesis: We aimed to determine if LVIDD impacts outcomes following LVAD insertion. Methods: A single center, retrospective review was performed of all patients (N=449) implanted with a continuous flow (CF) LVAD between 12/1999-12/2013. Demographics, preoperative and operative data, perioperative outcomes, echocardiographic and right heart catheterization data, and late survival were determined. Univariate and survival analyses were performed. Multivariable regression identified independent predictors of survival. Results: Patient characteristics, baseline echocardiographic and hemodynamic data, operative characteristics and clinical outcomes are summarized in Table 1. Patients with smaller LVIDD were more likely female...
What is the Best Clinical Test for Assessment of the Teres Minor in Massive Rotator Cuff Tears? (2015)

Level III, diagnostic study.
Deletion of Phd2 in Myeloid Lineage Attenuates Hypertensive Cardiovascular Remodeling (2013)

Phd2 deletion in myeloid lineage attenuates hypertensive cardiovascular hypertrophy and fibrosis, which may be mediated by decreased inflammation- and fibrosis-associated gene expression in macrophages. PHD2 in myeloid lineage plays a critical role in hypertensive cardiovascular remodeling.
A self-calibrating technique for starting 3-phase cage induction machines on single phase supply lines (2004)

A novel self-calibrating technique for starting 3-phase cage induction machines on a single-phase supply with no inrush currents is described. The method uses a simple starting circuit to bring the machine up to near its rated speed within a very short period of time by generating a very high starting torque. The already spinning motor is then connected to a single-phase supply to operate in a standard Steinmetz configuration, thus eliminating any inrush currents at starting. A self-calibration system built into the system starts the motor under the exact load conditions by determining the best transition time before connecting the motor to the mains supply. Numerical and analytical solutions for the transient behaviour of a 1.1 KW machine during starting under various operating conditions are presented and compared with experimental results. The method is simple and low in cost, and is particularly useful in rural applications where the supply lines are generally weak.
l-2‘,3‘-Didehydro-2‘,3‘-dideoxy-3‘-fluoronucleosides:  Synthesis, Anti-HIV Activity, Chemical and Enzymatic Stability, and Mechanism of Resistance (2003)

As antiviral nucleosides containing a 2',3'-unsaturated sugar moiety with 2'-fluoro substitution are endowed with increased stabilization of the glycosyl bond, it was of interest to investigate the influence of the fluorine atom at the 3'-position. Various pyrimidine and purine L-3'-fluoro-2',3'-unsaturated nucleosides were synthesized from their precursors, L-3',3'-difluoro-2',3'-dideoxy nucleosides, by elimination of hydrogen fluoride. In the L-3',3'-difluoro-2',3'-dideoxy nucleoside series, cytidine 16 and 5-fluorocytidine 18 analogues showed modest antiviral activity (EC(50) 11.5 and 8.8 microM, respectively) when evaluated against HIV-1 in human peripheral blood mononuclear (PBM) cells. In the 2',3'-unsaturated series, L-3'-fluoro-2',3'-didehydro-2',3'-dideoxycytidine 24 and 5-fluorocytidine 26 showed highly potent antiviral activity (EC(50) 0.089 and 0.018 microM, respectively) without significant cytotoxicity. The guanosine analogue 48 showed only marginal anti-HIV activity with some cytotoxicity (EC(50) 38.5 microM, and IC(50) 17.4, 58.4, 36.5 microM in PBM, CEM, and Vero cells, respectively). The cytidine 24 and 5-fluorocytidine 26 analogues, however, showed significantly decreased antiviral activity against the clinically important lamivudine-resistant variants (HIV-1(M184V)). Molecular modeling studies demonstrated that the 3'-fluoro atom of the L-3'-fluoro-2',3'-unsaturated nucleoside is within the hydrogen bonding distance with the amide backbone of Asp185, which favors the binding of the nucleoside triphosphate to the wild-type RT. This favorable binding mode, however, cannot be maintained when the triphosphate of 3'-fluoro 2',3'-unsaturated nucleoside binds to the active site of M184V RT because the bulky side chain of Val184 occupies the space needed for the nucleotide. The biological results suggest that, in addition to the sugar conformation, the base moiety may also play a role in their interaction with the M184V RT.
Dimethylsulfide (DMS) production from dimethylsulfoniopropionate by freshwater river sediments: phylogeny of Gram-positive DMS-producing isolates (2001)

Freshwater river sediments from both the Coastal Plain and Piedmont regions of South Carolina showed high rates of dimethylsulfide (DMS) production from added dimethylsulfoniopropionate (DMSP). These rates were considered to be high as they were ca. 1% of rates in salt marsh sediments. Most probable number enumeration of DMS producers in river water and sediments were also about 1% of those measured in estuarine water and salt marsh sediment. Tellurite and DMSP enrichments resulted in the isolation of tellurite-resistant Gram-positive nocardia-like DMS producers from freshwater, but not marine sediments. Gram-negative DMS producers, all capable of growth on DMSP, were isolated from both freshwater and salt marsh sediments. Sequencing the 16S rRNA genes of the most common freshwater isolates showed they were closely related to Rhodococcus equi and Rhodococcus rhodochrous, members of the family Nocardiaceae. This group, which made up 73% of the total number of freshwater sediment isolates, belonged to the phylogenetic class of high-GC, Gram-positive bacteria, a newly recognized group of DMS producers. The origin of DMSP-dependent DMS producers in a freshwater, nearly DMSP-free, environment is discussed.
Erythromycin Base-Induced Rash and Liver Function Disturbances (1992)

Erythromycin base must be added to the list of erythromycin derivatives that can cause rash and liver function disturbances. The concomitant appearance of fever, rash, jaundice, and liver function disturbances raises the possibility of hypersensitivity as the mechanism for the liver disturbances.
Accurate modeling of light trapping in thin film silicon solar cells (2002)

An attempt is made to assess the accuracy of the simplifying assumption of total retransmission of light inside the "escape" or "loss" cone which is made in many models of optical confinement in thin-film silicon solar cells. A closed form expression is derived for the absorption enhancement factor as a function of the refractive index in the low-absorption limit for a thin-film cell with a flat front surface and a lambertian back reflector. Numerical calculations are carried out to investigate similar systems with antireflection coatings, and the investigation of cells with a textured front surface is achieved using a modified version of the existing ray tracing computer simulation program TEXTURE.
Characterization of Hydrogen-Bonded Aggregates in Chloroform by Electrospray Ionization Mass Spectrometry (1996)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTCharacterization of Hydrogen-Bonded Aggregates in Chloroform by Electrospray Ionization Mass SpectrometryXueheng Cheng, Quanyin Gao, Richard D. Smith, Eric E. Simanek, Mathai Mammen, and George M. WhitesidesView Author Information Chemical Sciences Department and Environmental Molecular Sciences Laboratory, Pacific Northwest Laboratories, Richland, Washington 99352 Department of Chemistry, Harvard University, Cambridge, Massachusetts 02138 Cite this: J. Org. Chem. 1996, 61, 6, 2204–2206Publication Date (Web):March 22, 1996Publication History Received24 July 1995Revised7 December 1995Published online22 March 1996Published inissue 1 January 1996https://doi.org/10.1021/jo951345gCopyright © 1996 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views313Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (61 KB) Get e-AlertsSUBJECTS:Chemical structure,Dissociation,Ions,Mass spectrometry,Stability Get e-Alerts
Globalizing European Urban Bourgeoisie? Transnationalization and Rootedness of Managers in Four European Cities (2013)

In his lecture series, Patrick Le Galès contributes to the research agenda on governance that has been pioneered and developed at the MPIfG. He looks at three different dimensions in the governance of mobile societies. In his first lecture he discusses the question of who is being governed, i.e. what happens to European middle classes when they become more transnational and how do the European urban bourgeoisies combine exit and voice.
α1‐Antichymotrypsin Binding to Alzheimer Aβ Peptides Is Sequence Specific and Induces Fibril Disaggregation In Vitro (1993)

The serine protease inhibitor alpha 1-antichymotrypsin (ACT) consistently colocalizes with amyloid deposits of Alzheimer's disease (AD) and may contribute to the generation of amyloid proteins and/or physically affect fibril assembly. AD amyloid fibrils are composed primarily of A beta, which is a proteolytic fragment of the larger beta-amyloid precursor protein. Using negative-stain and immunochemical electron microscopy, we have investigated the binding of ACT to the fibrils formed by four synthetic A beta analogues corresponding to the wild-type human 1-40 sequence [Hwt(1-40)], a 1-40 peptide [HDu(1-40)] containing the Glu22-->Gln mutation found in hereditary cerebral hemorrhage with amyloidosis of the Dutch type, the N-terminal 1-28 residues [beta(1-28)], and an internal fragment of A beta containing residues 11-28 [beta(11-28)]. Each of these peptide analogues assembled into 70-90-A-diameter fibrils resembling native amyloid and, except for beta(11-28), bound ACT, as indicated by the appearance of 80-100-A globular particles that adhered to preformed fibrils and that could be decorated with anti-ACT antibodies. Under the conditions used, ACT binding destabilized the in vitro fibrils and produced a gradual dissolution of the macromolecular assemblies into constituent filaments and shorter fragments. The internal fragment (11-28) did not exhibit ACT binding or any structural changes. These results suggest that a specific sequence likely contained within the N-terminal 10 residues of A beta is responsible for the formation of the ACT-amyloid complex.(ABSTRACT TRUNCATED AT 250 WORDS)