gebhart/patrepeval huggingface dataset:
SRv6-PM: A Cloud-Native Architecture for Performance Monitoring of SRv6 Networks (2021)

Segment Routing over IPv6 (SRv6 in short) is a networking architecture suitable for both IP backbones and datacenters. The research, standardization and implementation of this architecture are actively progressing and SRv6 is already adopted in a number of large scale deployments. Effective solutions for Performance Monitoring (PM) of SRv6 networks are strongly needed and there is a lot of activity in this area. A full blown Performance Monitoring solution needs to include: i) Data Plane (as needed to measure metrics such as packet loss and delay); ii) Control Plane (to send commands to the monitoring entities in the nodes); iii) Management Plane (e.g., to collect the measured metrics). Moreover, Big-Data tools and solutions can be applied inside or above the traditional Management Plane boundaries to store and analyze the collected data. In this article we describe SRv6-PM, a solution for Performance Monitoring of SRv6 networks that deals with all the aspects discussed above. SRv6-PM features a cloud-native architecture that supports: i) the ingestion, processing, storage and visualization of PM data using Big-Data tools; ii) the SDN-based control of network routers to drive the performance monitoring operations. In particular, we focus on Loss Monitoring and consider a solution capable of tracking single packet loss events operating in near-real time (e.g., with a time granularity in the order of 10-20 seconds). SRv6-PM is released as open source. We offer a re-usable and extensible platform that can be automatically deployed in different environments, from a single host to multiple servers on private/public clouds and includes a set of Big-Data tools and the SDN control plane. We also provide a reproducible Data Plane environment for PM experiments in SRv6 networks based on the Mininet emulator.
MP39-17 A NOVEL COMBINATORIAL THERAPY IN RENAL CELL CARCINOMA: SILENCING SEMAPHORIN 3C IN COMBINATION WITH SUNITINIB (2015)

and also significantly higher in RCC samples as compared to normal kidney samples (p<0.0001). The higher expression of versican was significantly correlated with high stage disease and systematic metastasis (p<0.05). When the expression level of the versican mRNA transcript was divided into 2 groups based on median values, higher expression was significantly associated with overall survival (OS) after a radical nephrectomy (p0.0235). After transfection of versican siRNA, cell viability, migration, and invasion ability were significantly inhibited in the RCC cell lines.
Development of an Electrochemical Process for the Simultaneous Treatment of Wastewater and the Conversion of Carbon Dioxide to Higher Value Products (2016)

Abstract Many researchers have shown that selected anodic processes allow effective treatment of a very large amount of wastewater contaminated by pollutants resistant to biological processes. In the meantime, various authors have also shown that carbon dioxide can be converted into higher value products, such as formic acid or synthesis gas, by cathodic reduction at suitable cathodes. These two processes present interesting economic potential that, however, still needs to be improved for further development at an industrial level. Herein, these two kinds of process are combined in the same cell to improve their economic feasibility. In particular, the anodic treatment of wastewater at a boron‐doped diamond anode and the cathodic reduction of carbon dioxide to formic acid at a tin cathode are performed simultaneously in a divided cell. Aqueous solutions of Acid Orange 7, which is a widely used azoic dye resistant to conventional biological processes, are used as a model for wastewater. The effect of various operating parameters (including current density, mixing rate, and pH) on both processes is studied. It is possible, under optimized operating conditions, to successfully achieve in a single reactor both the treatment of wastewater contaminated by resistant pollutants and the conversion of carbon dioxide into formic acid. This paired electrolysis process can improve substantially economic figures with respect to each separate process.
Pharmacokinetics of 3′-azido-2′,3′-dideoxy-5-methylcytidine in Rats (1990)

3′-Azido-2′,3′-dideoxy-5-methylcytidine (AzddMeC) has been shown to have potent activity against human immunodeficiency virus (HIV) in vitro. The purpose of this study was to characterize the pharmacokinetics of AzddMeC in rats. AzddMeC was administered intravenously at doses of 10, 50 and 100 mg kg −1 . Plasma and urine AzddMeC concentrations were determined by HPLC. Pharmacokinetic parameters were generated by area/moment analysis. Plasma AzddMeC concentrations after 10mg kg −1 were too low to accurately calculate pharmacokinetic parameters. Following 50 and 100mg kg −1 AzddMeC, plasma drug concentrations declined rapidly with a terminal half-life of approximately 2.5 h. No statistically significant differences were noted in pharmacokinetic parameters between the two higher doses. Total clearance was 1.57 ± 0.33 (mean ± SD) and 1.76 ± 0.32I h −1 kg −1 after 50 and 100 mg kg −1 AzddMeC, respectively. Renal excretion accounted for approximately half of total clearance with 55 ± 11% of the dose recovered as unchanged drug in urine. AzddMeC was not metabolized by deamination to AZT in the rat. No glucuronide metabolite was found in urine. Steady-state volume of distribution of AzddMeC averaged 1.73 ± 0.78 and 1.46 ± 0.441 kg −1 following 50 and 100 mg kg −1 , respectively. Thus, the disposition of AzddMeC in rats is independent of dose over the range of 50–100 mg kg −1 . The pharmacokinetics of AzddMeC in rats are similar to those of 2′,3′-dideoxycytidine, while the clearance of AzddMeC is 40% less than that of 3′-azido-3′-deoxythymidine.
E110 Development of innovative low NOx coal burner (2010)

Coal is one of the important energy sources due to its abundant reserve and the market of coal fired boiler are expected to increase further. However, when using coal, it is essential to reduce environmental burdens such as high CO_2 and NOx generation. We succeeded to decrease NOx generation by 40% with developed state-of-the-art low NOx coal burner based on the new innovative concept. Developed burner also contributes to CO_2 reduction, since boiler efficiency can be improved by operating with low excess air ratio (<10%) and low unburned carbon in fly ash due to enhanced ignition. Furthermore, NOx generation can be reduced in spite of low AA ratio condition, which mitigates corrosion of the boiler furnace wall by H_2S. Accordingly, new burner realizes substantially boiler operation and maintenance cost reduction.
Terbium(III) Luminescence-Based Assay for Esterase Activity (2019)

Esterases catalyze the hydrolysis of esters to form a carboxylic acid and alcohol. These enzymes play a key role in both the detoxification of xenobiotic compounds and the metabolism of drugs and prodrugs. Numerous fluorogenic probes have been developed to monitor esterase activity. Most are based on an aromatic alcohol, and the others are based on an aromatic acid. These restrictions leave unexplored the specificity of esterases for aliphatic esters. Here, we report on the use of esters of thiopheneacetic acid coupled with the luminescence of terbium(III) as the basis for a continuous assay of esterase activity. This probe allows for a wide variation of the alcohol moiety and the detection of its hydrolysis at submicromolar concentrations. The assay verifies steady-state kinetic parameters for catalysis by pig liver esterase from either initial rates or the integration of progress curves, and its utility is evident with unpurified esterases in bacterial and human cell lysates.
Image systems engineering at Stanford (2002)

A new Image Systems Engineering Program (ISEP) has recently been launched at Stanford University. The program includes more than a dozen faculty participants drawn from four departments. The planned stages of growth of the Program are described, with emphasis on the anticipated respective roles of the university and industry.
CHARACTERIZATION OF FLUORESCENT NUCLEAR TRACK DETECTORS AS CRITICALITY DOSIMETERS II (2017)

Fluorescent nuclear track detectors (FNTDs) as criticality dosimeters for both neutrons and gamma are further characterized in terms of angular dependence and quick dose assessment. The power spectrum integral depth profiles obtained from stacks of fluorescent images acquired within FNTDs exposed to a broad spectrum neutron field at various angles are analyzed to determine a calibration curve for angular dependence. MCNPX simulations were shown to be in good agreement with experimental results. A prototype triage reader was also designed and tested for quick assessment of dose. An unfolding technique incorporating both energy dependence and angular dependence is discussed. The advantages and shortcomings of using FNTDs in the event of a criticality excursion accident are analyzed.
Castration Resistance in Prostate Cancer Is Mediated by the Kinase NEK6 (2016)

In prostate cancer, the development of castration resistance is pivotal in progression to aggressive disease. However, understanding of the pathways involved remains incomplete. In this study, we performed a high-throughput genetic screen to identify kinases that enable tumor formation by androgen-dependent prostate epithelial (LHSR-AR) cells under androgen-deprived conditions. In addition to the identification of known mediators of castration resistance, which served to validate the screen, we identified a mitotic-related serine/threonine kinase, NEK6, as a mediator of androgen-independent tumor growth. NEK6 was overexpressed in a subset of human prostate cancers. Silencing NEK6 in castration-resistant cancer cells was sufficient to restore sensitivity to castration in a mouse xenograft model system. Tumors in which castration resistance was conferred by NEK6 were predominantly squamous in histology with no evidence of AR signaling. Gene expression profiling suggested that NEK6 overexpression stimulated cytoskeletal, differentiation, and immune signaling pathways and maintained gene expression patterns normally decreased by castration. Phosphoproteome profiling revealed the transcription factor FOXJ2 as a novel NEK6 substrate, with FOXJ2 phosphorylation associated with increased expression of newly identified NEK6 transcriptional targets. Overall, our studies establish NEK6 signaling as a central mechanism mediating castration-resistant prostate cancer. Cancer Res; 77(3); 753-65. ©2016 AACR.
Deadbeat-Direct Torque and Flux Control of Wound Field Synchronous Machine at Low Sampling to Fundamental Frequency Ratios (2019)

Enhancements to the deadbeat-direct torque and flux control (DB-DTFC) of wound field synchronous machines (WFSMs) are proposed allowing for operation at low sampling frequency to fundamental frequency ratios. Discrete-time current and flux linkage observers, which properly model WFSM d-q and d-f cross-coupling are formed using a Taylor series approximated sampled Laplace approach. The effect of the Taylor series order on the discretization error and model accuracy is examined. The torque curve to determine the inverter voltage commands is derived from the flux linkage model coefficients. Experimental comparison of the WFSM torque response is made between the classical DB-DTFC with current and flux observers formed using a z-transform approach and the torque line derived from a forward Euler method and the newly proposed observers and torque curve.
Evidence for Serpulina hyodysenteriae being recombinant, with an epidemic population structure (1997)

The population structure of Serpulina hyodysenteriae was investigated using multilocus enzyme electrophoresis. A total of 231 isolates were divided into 50 electrophoretic types (ETs), with a mean genetic diversity of 0.29 for the number of ETs and 0.23 for the number of isolates. Subsets of isolates from two Australian states (71 isolates from Victoria and 68 isolates from Queensland) exhibited as much genetic variation as the entire collection. The calculated index of association (IA) for the number of ETs (0.29 +/- 0.17) was not significantly different from zero, and hence provided evidence for the occurrence of significant genetic recombination accounting for the observed variation between strains. In contrast, the IA for the number of isolates (3.93 +/- 0.03) was significantly different from zero, with seven of the 50 ETs (ETs 4, 6, 13, 14, 20, 33 and 35) containing 51% of all the isolates. Even when multiple isolates from the same farm were removed from the analysis, the IA value for the number of isolates remained significantly greater than zero (IA 9.87 +/- 0.04), indicating that it was not biased by their inclusion. The results suggest that S. hyodysenteriae has an epidemic population structure.
THE IMPACT OF A STATIC-MIXING NOZZLE ON UNIFORMITY IN MATERIAL EXTRUSION LARGE-SCALE ADDITIVE MANUFACTURING (2022)

There are many methods of incorporating more than one material in Additive Manufacturing (AM) processes. Oak Ridge National Laboratory has developed a unique solution that enables in-situ material switching by developing a dual-hopper feed system for Cincinnati’s Big Area Additive Manufacturing (BAAM) system. Continuous extrusion during a step-change in material feedstock results in a unique blended material transition region that exhibits a heterogeneous internal morphology. To improve mixing of materials during extrusion, a customized static-mixing nozzle was created for use with the BAAM. Single-bead transitions from Material A to B and B to A were printed with the mixing nozzle at a specified screw speed. Compositional analysis tracked the progression of the material transition as a function of extrudate volume. The resulting transition curves were compared against a standard nozzle configuration. Optical microscopy of cross sections also demonstrated that the static-mixing nozzle promoted a more uniform bead geometry as well as a more homogeneous internal structure throughout the material transition.
The long term impact of codesign (2012)

This article consists of a collection of slides from the author's conference presentation. Some of the specific areas/topics discussed include: Why co-design?; The technology factors and bifurcation forces; Where co-design will bring us in 10-15 years; Measuring our progress.
Cross-Linked Binders with Metallic Ions for Si-Based Electrodes in Li-Ion Batteries (2020)

Silicon is a very promising anode material for Li-ion batteries due to its much higher storage capacity than graphite [1]. However, its huge volume expansion upon lithiation induces major mechanical degradation of the electrode, resulting in a poor cycle life. In this context, the optimization of the binder properties used for the electrode processing is crucial. In the present work, the impact of the addition of metallic ions ( e.g. Zn 2+ ) in the electrode formulation, likely to chemically crosslink carboxylate groups of the binder ( e.g. carboxymethyl cellulose) is studied. The formation of COO-metal coordination bonds is confirmed from IR spectroscopy analyses and its impact on the rheological properties of the ink, the mechanical strength of the coating and the electrochemical performance of the electrode is highlighted. This approach, with the myriad of possibilities of coordination chemistry, opens very interesting prospects for designing a novel class of smart binders for lithium-ion batteries. [1] M.N. Obrovac, V.L. Chevrier, Alloy Negative Electrodes for Li-Ion Batteries. Chem. Rev. 2014 , 114, 11444-11502.
Quantitative Measurements of Direct-Injection Gasoline Fuel Sprays in Near-Nozzle Region Using Synchrotron X-Ray (2001)

&lt;div class="htmlview paragraph"&gt;A quantitative and time-resolved technique has been developed to probe the dense spray structure of direct-injection (DI) gasoline sprays in near-nozzle region. This technique uses the line-of-sight absorption of monochromatic x-rays from a synchrotron source to measure the fuel mass with time resolution better than 1 μs. The small scattering cross-section of fuel at x-rays regime allows direct measurements of spray structure that are difficult with most visible-light optical techniques. Appropriate models were developed to determine the fuel density as a function of time.&lt;/div&gt;
Postsynthesis‐Treated Iron‐Based Metal–Organic Frameworks as Selective Catalysts for the Sustainable Synthesis of Nitriles (2015)

The dehydration of aldoximes to the corresponding nitriles can be performed with excellent activity and selectivity by using iron trimesate as a homogeneous catalyst. Iron trimesate has been heterogenized by synthesizing metal-organic frameworks (MOFs) from iron trimesate, that is, Fe(BTC), and MIL-100 (Fe). These materials were active and selective aldoxime dehydration catalysts, and postsynthesis-treated MIL-100 (Fe) produced the desired nitriles with 100 % conversion and selectivities >90 % under mild reaction conditions and in short reaction times. X-ray photoelectron spectroscopy showed the presence of different Fe species in the catalyst, and in situ IR spectroscopy combined with catalytic results indicates that the catalytic activity is associated with Fe framework species. The postsynthesis-treated MIL-100 (Fe)-NH4 F can be recycled several times and has an excellent reaction scope, which gives better catalytic results than other solid acid or base catalysts.
Representability of METT-TC Factors in JC3IEDM (2007)

Commanders require relevant information about background information in order to exercise effective command and control (C2). METT-TC factors (Mission, Enemy, Terrain &amp; Weather, Troops, Time Available and Civil Considerations) represent the canonical, militarily significant background against which information is evaluated and military decisions are made. If this background is to be encoded, shared, and, ultimately, processed and reasoned about by computers or computer-assisted C2 systems, the METT-TC background must be represented in some standard format with a shared computer-processable semantics. The JC3IEDM (Joint Command, Control, and Consultation Information Exchange Data Model) represents several years of effort by NATO's Multinational Interoperability Programme at developing a representation of military situations in order to support communication and interoperability among NATO forces. All information to be shared by participants must, therefore, be representable within JC3IEDM. In this paper, we point out aspects of METT-TC that are not currently or not completely representable in JC3IEDM. These include aspects such as cover and concealment, fields of fire, and mission purpose. We end by suggesting ways in which JC3IEDM can be extended to represent these aspects of METT-TC factors.
A new pyrene cored small organic molecule with a flexible alkyl spacer: a potential solution processable blue emitter with bright photoluminescence (2017)

A new pyrene cored small organic molecule exhibiting a high PLQY and blue emission was designed and synthesized.
The Novel IgD Binding Protein from Moraxella catarrhalis Induces Human B Lymphocyte Activation and Ig Secretion in the Presence of Th2 Cytokines (2002)

Moraxella IgD binding protein (MID) is a novel bacterial outer membrane protein with IgD-binding properties. MID was purified from the respiratory pathogen Moraxella catarrhalis and is here shown to have B cell stimulatory properties. Purified MID in the range of 0.01-0.1 microg/ml was optimal to induce a proliferative response in human PBL. MID coupled to Sepharose and formalin-fixed M. catarrhalis preparations induced similar proliferative responses in PBL cultures. MID or MID-Sepharose stimulated purified human peripheral B cells as measured by proliferation. In contrast, MID or MID-Sepharose did not activate T cells. Preincubation of purified B cells with anti-IgD Abs inhibited MID-Sepharose-induced B cell proliferation. The addition of IL-4 specifically induced IL-6 production in MID-Sepharose-activated B cells. IgM secretion was detected in B cell cultures stimulated with MID or MID-Sepharose and IL-2 for 10 days. Secretion of IgG and IgA was efficiently induced in cultures from purified B cells stimulated with the combination of MID or MID-Sepharose and IL-4, IL-10, and soluble CD40 ligand, suggesting that Th2-derived cytokines were required for optimal plasma cell generation. Taken together, MID has properties that make it an important tool to study IgD-targeted activation of B cells.
Practical Broadcast Encryption from Graph-Theoretic Techniques and Subset-Incremental-Chain Structure (2007)

We present generic frameworks for constructing efficient broadcast encryption schemes in the subset-cover paradigm, introduced by Naor et al., based on various key derivation techniques. Our frameworks characterize any instantiation completely to its underlying graph decompositions, which are purely combinatorial in nature. These abstract away the security of each instantiated scheme to be guaranteed by the generic one of the frameworks; thus, give flexibilities in designing schemes. Behind these, we present new techniques based on (trapdoor) RSA accumulators utilized to obtain practical performances. We then give some efficient instantiations from the frameworks, via a new structure called subset-incremental-chain. Our first construction improves the currently best schemes, including the one proposed by Goodrich et al., without any further assumptions (only pseudo-random generators are used) by some factors. The second instantiation, which is the most efficient, is instantiated based on RSA and directly improves the first scheme. Its ciphertext length is of order O(r), the key size is O(1), and its computational cost is O(n1/klog2n) for any (arbitrary large) constant k; where r and n are the number of revoked users and all users respectively. To the best of our knowledge, this is the first explicit collusion-secure scheme in the literature that achieves both ciphertext size and key size independent of n simultaneously while keeping all other costs efficient, in particular, sub-linear in n. The third scheme improves Gentry and Ramzan's scheme, which itself is more efficient than the above schemes in the aspect of asymptotic computational cost.
Crystallization Behavior of Polypropylene and Its Blends and Composites (2023)

Polypropylene has developed into one of the most relevant thermoplastic polymers, both technically and commercially, since its development in the 1950s. Both the far more relevant isotactic variety and the syndiotactic polymer are crystalline with an interesting polymorphism, and they can be modified by copolymerization and blending to cover a wide range of mechanical and optical properties. The different crystal polymorphs can be controlled by chain structure and nucleation, allowing either higher stiffness or toughness and facilitated processing. In multiphase systems with amorphous and crystalline inclusions, especially polyethylene shows relevant epitactic interaction. Processing effects related to cooling rate and flow further determine crystalline morphology and performance. A wide variety of characterization methods are available today to study the related phenomena.
Solvent free synthesis of 1-alkoxyphosphonium chlorides for stereoselective multipurpose vinyl ethers (2019)

An efficient solvent free method is developed for the preparation of structurally diverse 1-alkoxymethylphosphonium chlorides in high yield. One of the prepared salts derived from (1 R,2S,5R)-(−)-Menthol auxiliary was further employed for the synthesis of vinyl ethers, where up to 99% stereoselectivity was achieved.