gebhart/patrepeval huggingface dataset:
Triacrylamide-Based Adhesives Stabilize Bonds in Physiologic Conditions (2022)

In this study, an acrylamide-based adhesive was combined with a thiourethane-based composite to improve bond stability and reduce polymerization stress, respectively, of simulated composite restorations. The stability testing was conducted under physiologic conditions, combining mechanical and bacterial challenges. Urethane dimethacrylate was combined with a newly synthesized triacrylamide (TMAAEA) or HEMA (2-hydroxyethyl-methacrylate; control) to produce a 2-step total-etch adhesive system. Methacrylate-based composites (70 wt% silanized filler) were formulated, containing thiourethane oligomers at 0 (control) or 20 wt%. Standardized preparations in human third molars were restored; then, epoxy replicas were obtained from the occlusal surfaces before and after 7-d storage in water or with <i>Streptococcus mutans</i> biofilm, which was tested after storage in an incubator (static) or the bioreactor (mechanical challenge). Images were obtained from the replicas (scanning electron microscopy) and cross sections of the samples (confocal laser scanning microscopy) and then analyzed to obtain measurements of gap, bacterial infiltration, and demineralization. Microtensile bond strength of specimens stored in water or biofilm was assessed in 1-mm<sup>2</sup> stick specimens. Data were analyzed with analysis of variance and Tukey's test (α = 0.05). HEMA-based materials had greater initial gap measurements, indicating more efficient bonding for the acrylamide materials. When tested in water, the triacrylamide-based adhesive had smaller gaps in the incubator or bioreactor. In the presence of biofilm, there was less difference among materials, but the acrylamide/thiourethane combination led to statistically lower gap formation in the bioreactor. HEMA and TMAAEA-based adhesives produced statistically similar microtensile bond strengths after being stored in water for 7 d, but after the same period with biofilm-challenged specimens, the TMAAEA-based adhesives were the only ones to retain the initial bond strength values. The use of a stable multiacrylamide-based adhesive led to the preservation of the resin-dentin bonded interface after a physiologically relevant challenge. Future studies will include a multispecies biofilm model.
Trends in Orbital Decompression Techniques of Surveyed American Society of Ophthalmic Plastic and Reconstructive Surgery Members (2015)

The majority of surveyed ASOPRS surgeons prefer a combined wall approach over single wall approach to initial orbital decompression. Despite the technological advances made in the field of modern endoscopic surgery, no single approach has been adopted by the ASOPRS community as the gold standard.
Antenna Design for UHF RFID Near-Field Applications (2013)

International audience
Partial purification and characterization of a vascular permeability factor secreted by a human colon adenocarcinoma cell line (1985)

The established human colon adenocarcinoma cell line, HT-29, secretes a vascular permeability factor (VPF) in vitro. The factor has been purified from serum-free conditioned medium by acidification, cation-exchange, and reverse-phase and anion-exchange high-performance liquid chromatography. The VPF is a non-glycosylated acidic protein of apparent molecular weight 45,000, and is at least 4 orders of magnitude more potent than histamine as an inducer of vascular permeability. Its biological activity is unaffected by soybean trypsin inhibitor or by inhibitors of histamine, kinins, prostaglandins, or acid proteases. The VPF induces vascular permeability within minutes, which suggests a direct effect on the endothelial cell.
Characterization of a New Subfamily of Winged-helix/Forkhead (Fox) Genes That Are Expressed in the Lung and Act as Transcriptional Repressors (2001)

Epithelial gene expression in the lung is thought to be regulated by the coordinate activity of several different families of transcription factors including the Fox family of winged-helix/forkhead DNA-binding proteins. In this report, we have identified and characterized two members of this Fox gene family, Foxp1 and Foxp2, and show that they comprise a new subfamily of Fox genes expressed in the lung. Foxp1 and Foxp2 are expressed at high levels in the lung as early as E12.5 of mouse development with Foxp2 expression restricted to the airway epithelium. In addition, Foxp1 and Foxp2 are expressed at lower levels in neural, intestinal, and cardiovascular tissues during development. Upon differentiation of the airway epithelium along the proximal-distal axis, Foxp2 expression becomes restricted to the distal alveolar epithelium whereas Foxp1 expression is observed in the distal epithelium and mesenchyme. Foxp1 and Foxp2 can regulate epithelial lung gene transcription as was demonstrated by their ability to dramatically repress the mouse CC10 promoter and, to a lesser extent, the human surfactant protein C promoter. In addition, GAL4 fusion proteins encoding subdomains of Foxp1 and Foxp2 demonstrate that an independent and homologous transcriptional repression domain lies within the N-terminal end of the proteins. Together, these studies suggest that Foxp1 and Foxp2 are important regulators of lung epithelial gene transcription.
Dermaland (2010)

Dermaland is an installation that combines different interaction paradigms and devices that aims to promote children's awareness about the risks of UV radiation on the human skin and on the environment. It allows children to learn in a very unassuming way about two linked branches of science- dermatology and ecology. The approach is intuitive and non-didactic, based on the experiential value of the dramaturgy rather than on a set of obvious educational steps. Through employment of simple augmented objects, robots and associated projections of cellular representations, users tend to accumulate knowledge over time. This research extends that of groups who study the extent to which children can experience more abstract concepts through interactive play [2]. Dermaland was already shown at the Museum for Design in Zurich, Switzerland from June-October 2009, and the interaction was observed and analyzed through video analysis in this same environment.
Synthesis and Antiviral Evaluation of 2-Mercapto-5,6-dichlorobenzimidazole-β-D-ribofuranonucleoside Derivatives (1994)

Abstract 2-Mercapto-5,6-dichlorobenzimidazole β-D-ribofuranonucleoside derivatives 8–10 have been synthesized and their antiviral properties examined. According to the glycosylation procedure used, the β-D-N-1 isomer (and the N, N-bis-riboside) or the β-D-S2-isomer have been obtained. All the prepared compounds were tested for their activity against a variety of RNA and DNA viruses, but they did not show significant antiviral activity.
Direct syntheses of polyfused ring systems by intramolecular tandem palladium-ene/Heck insertion reactions (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDirect syntheses of polyfused ring systems by intramolecular tandem palladium-ene/Heck insertion reactionsWolfgang Oppolzer and Robert J. DeVitaCite this: J. Org. Chem. 1991, 56, 22, 6256–6257Publication Date (Print):October 1, 1991Publication History Published online1 May 2002Published inissue 1 October 1991https://pubs.acs.org/doi/10.1021/jo00022a004https://doi.org/10.1021/jo00022a004research-articleACS PublicationsRequest reuse permissionsArticle Views585Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The effect of temperature and initiator levels on the dispersion polymerization of polystyrene (1987)

Abstract Considerable interest has been generated recently by the preparation of large monodisperse polymer latices by a multistage swelling process. Dispersion polymerization in organic media has been shown to be an alternative route to the preparation of large monodisperse polymer colloids. The size of the resulting particles is known to be dependent on the polarity of the reaction medium. Several other factors are also extremely important in determining both the size and size distribution of the resulting particles. These include the temperature of the reaction and the level of initiator. The temperature affects both the rate of free radical formation and the thermodynamic properties of the polymerization system. It is shown that monodispersity can be achieved over a considerable range of temperatures provided that a particular level of initiator is used at a given temperature. It is also shown that higher levels of initiator at a particular temperature actually produced larger particles. Interestingly, the level of initiator was not found to significantly change the overall rate of polymerization.
Piezoresistive Feedback Control of a MEMS Thermal Actuator (2009)

Feedback control of microelectromechanical systems (MEMS) devices has the potential to significantly improve device performance and reliability. One of the main obstacles to its broader use is the small number of on-chip sensing options that are available to MEMS designers. A method of using integrated piezoresistive sensing is proposed and demonstrated as another option. Integrated piezoresistive sensing utilizes the inherent piezoresistive property of polycrystalline silicon from which many MEMS devices are fabricated. As compliant MEMS structures flex to perform their functions, their resistance changes. That resistance change can be used to transduce the structures' deflection into an electrical signal. The piezoresistive microdisplacement transducer (PMT) is a demonstration structure that uses integrated piezoresistive sensing to monitor the output displacement of a thermomechanical inplane microactuator (TIM). Using the PMT as a feedback sensor for closed-loop control of the TIM provided excellent tracking with no evident steady-state error, maintained the positioning resolution to plusmn29 nm or less, and increased the robustness of the system such that it was insensitive to significant damage.
Low Frequency Noise sensitivity to technology induced mechanical stress in MOSFETs (2005)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Paolo Fantini, Giorgio Ferrari; Low Frequency Noise sensitivity to technology induced mechanical stress in MOSFETs. AIP Conf. Proc. 25 August 2005; 780 (1): 191–194. https://doi.org/10.1063/1.2036729 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Modeling Conformance as Dispersion (2009)

Summary For decades the effect of physical dispersion (in-situ mixing) in porous media has been of interest in reservoir engineering and groundwater hydrology. Dispersion can affect the development of multicontact miscibility and bank breakdown in enriched-gas drives and miscible solvent floods of any mobility ratio. The magnitude or extent of dispersion is quantified by the rock property physical dispersivity, α, which is on the order of 0.01 ft for consolidated rocks and several times smaller for sandpacks, as found in many laboratory measurements. Numerical studies of the effect of dispersion on enriched-gas drives and field tracer tests often use input values of a scale-dependent dispersivity 100 to 1,000 or more times larger than ≈0.01 ft. These large scale-dependent dispersivity values stem from large apparent dispersivities (αa) determined by matching the 1D convection/diffusion (C/D) equation to production-well-effluent tracer-concentration profiles observed in field tracer tests. A scale-dependent dispersivity can be used only as a fitting factor to match or explain the effluent profile of a single producer at a fixed distance from an injector. It cannot represent physical dispersion to justify the conclusions reached by its use in simulations of enriched-gas-drive, field-tracer-test, or other reservoir displacement processes. It has no predictive value in any numerical simulation. The scale-dependent apparent dispersivities reflect conformance or other behavior not governed by the 1D C/D equation and should not be used to justify large dispersivities as input to numerical studies. This paper shows that large apparent dispersivities observed in field tests can result with physical dispersivity no larger than the ≈0.01-ft laboratory-measured value. Heterogeneity alone (no physical dispersivity or molecular diffusion) causes no in-situ mixing and cannot explain observed large apparent echo-test dispersivities. Large apparent dispersivities for two reported echo (single-well inject/produce) tracer tests are shown to result from a model with drift alone and no dispersion. The widely reported scale dependence of apparent dispersivity is a simple and necessary consequence of mis-applying the 1D C/D equation, with its single parameter of Peclet number, L/α, to conformance it does not describe. The conformance portion, aac, of apparent dispersivity, αa, is scale-dependent, but physical dispersivity is a rock property independent of scale and time. The value of αa approximately obeys an additive dispersivity principle, αa≈α + αac, where αac is dispersivity representing conformance and αaG&amp;gt;&amp;gt;α in field displacements.
Coping with Noisy Training Data Labels in Paraphrase Detection (2021)

We present new state-of-the-art benchmarks for paraphrase detection on all six languages in the Opusparcus sentential paraphrase corpus: English, Finnish, French, German, Russian, and Swedish. We reach these baselines by finetuning BERT. The best results are achieved on smaller and cleaner subsets of the training sets than was observed in previous research. Additionally, we study a translation-based approach that is competitive for the languages with more limited and noisier training data.
Comparison of Irlen scotopic sensitivity syndrome test results to academic and visual performance data. (1994)

Many questions about the use of colored filters for the treatment of reading problems remain unanswered. Among these are questions dealing with whether the M-pathway anomalies found in some dyslexics are also present to a lesser degree in other cases of reading disabilities, and how colored filters could re-balance the M- and P-pathways. Is it the color of the filter itself that is critical, or is it the change in luminance or contrast produced by the filter that seems to make it easier for some subjects to read? More research will be needed to answer these questions.
CDK6 is an essential direct target of NUP98 fusion proteins in acute myeloid leukemia (2020)

Fusion proteins involving Nucleoporin 98 (NUP98) are recurrently found in acute myeloid leukemia (AML) and are associated with poor prognosis. Lack of mechanistic insight into NUP98-fusion-dependent oncogenic transformation has so far precluded the development of rational targeted therapies. We reasoned that different NUP98-fusion proteins deregulate a common set of transcriptional targets that might be exploitable for therapy. To decipher transcriptional programs controlled by diverse NUP98-fusion proteins, we developed mouse models for regulatable expression of NUP98/NSD1, NUP98/JARID1A, and NUP98/DDX10. By integrating chromatin occupancy profiles of NUP98-fusion proteins with transcriptome profiling upon acute fusion protein inactivation in vivo, we defined the core set of direct transcriptional targets of NUP98-fusion proteins. Among those, CDK6 was highly expressed in murine and human AML samples. Loss of CDK6 severely attenuated NUP98-fusion-driven leukemogenesis, and NUP98-fusion AML was sensitive to pharmacologic CDK6 inhibition in vitro and in vivo. These findings identify CDK6 as a conserved, critical direct target of NUP98-fusion proteins, proposing CDK4/CDK6 inhibitors as a new rational treatment option for AML patients with NUP98-fusions.
Data from Cyclin G1 Is a Target of miR-122a, a MicroRNA Frequently Down-regulated in Human Hepatocellular Carcinoma (2023)

&lt;div&gt;Abstract&lt;p&gt;We investigated the role of microRNAs (miRNAs) in the pathogenesis of human hepatocellular carcinoma (HCC). A genome-wide miRNA microarray was used to identify differentially expressed miRNAs in HCCs arisen on cirrhotic livers. Thirty-five miRNAs were identified. Several of these miRNAs were previously found deregulated in other human cancers, such as members of the &lt;i&gt;let-7&lt;/i&gt; family, &lt;i&gt;mir-221,&lt;/i&gt; and &lt;i&gt;mir-145&lt;/i&gt;. In addition, the hepato-specific &lt;i&gt;miR-122a&lt;/i&gt; was found down-regulated in ∼70% of HCCs and in all HCC-derived cell lines. Microarray data for &lt;i&gt;let-7a, mir-221,&lt;/i&gt; and &lt;i&gt;mir-122a&lt;/i&gt; were validated by Northern blot and real-time PCR analysis. Understanding the contribution of deregulated miRNAs to cancer requires the identification of gene targets. Here, we show that &lt;i&gt;miR-122a&lt;/i&gt; can modulate cyclin G1 expression in HCC-derived cell lines and an inverse correlation between &lt;i&gt;miR-122a&lt;/i&gt; and cyclin G1 expression exists in primary liver carcinomas. These results indicate that cyclin G1 is a target of &lt;i&gt;miR-122a&lt;/i&gt; and expand our knowledge of the molecular alterations involved in HCC pathogenesis and of the role of miRNAs in human cancer. [Cancer Res 2007;67(13):6092–9]&lt;/p&gt;&lt;/div&gt;
Bioorthogonal Small Molecule Imaging Agents Allow Single-Cell Imaging of MET (2013)

The hepatocyte growth factor receptor (MET) is a receptor tyrosine kinase (RTK) that has emerged as an important cancer target. Consequently, a number of different inhibitors varying in specificity are currently in clinical development. However, to date, it has been difficult to visualize MET expression, intracellular drug distribution and small molecule MET inhibition. Using a bioorthogonal approach, we have developed two companion imaging drugs based on both mono- and polypharmacological MET inhibitors. We show exquisite drug and target co-localization that can be visualized at single-cell resolution. The developed agents may be useful chemical biology tools to investigate single-cell pharmacokinetics and pharmacodynamics of MET inhibitors.
Design and Development of a Novel Infant Surgical Table for 4-DOF Patient Manipulation (2007)

Retinopathy of Prematurity, caused by abnormal blood vessel development in the retina of premature infants, is a leading cause of childhood blindness. It is treated using laser photocoagulation. Current methods require the surgeon to assume awkward standing positions, which can result in injury to the surgeon if repeated often. To assist surgeons in providing quality care and prevent occupational injury, a new infant surgical table was designed. The engineered solution is an attachment to a standard surgical table, saving cost and space. This takes advantage of the adjustable height and tilt provided by the standard table, while 360° rotation designed into the attachment allows the surgeon to sit during surgery. The critical cords and tubes are routed through the attachment to avoid pulling and kinking. A four-bar locking mechanism allows easy attachment to standard medical railing. Finally, a straight line mechanism provides positive locking of the rotation, allowing precise positioning of the infant.
Higher order singularities of regional manipulators (2002)

The conics method is applied to an analysis of the workspace of a 3R regional manipulator. Specifically, the boundary curve of the workspace is investigated. For the 3R manipulator, it is demonstrated that higher-order root multiplicities of the inverse kinematics correspond to singular points of the workspace region boundary curve. An example of such a point is given.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The association of mannose-binding lectin 2 polymorphisms with outcome in very low birth weight infants (2017)

In a large cohort of VLBWI MBL2 deficiency had no major impact on infection risk unless children were born between 32 0/7 and 36 6/7 weeks of gestation.
Monolithically Integrated 10Gbit/sec Silicon Modulator with Driver in 0.25µm SiGe:C BiCMOS (2013)

We present the first monolithic photonic integration in the electronic frontend of a high-performance BiCMOS technology. 10Gbit/sec operation of a Silicon Mach-Zehnder modulator device with 8dB extinction in dual-drive is demonstrated.
Numerical investigation into slitted leading-edge profiles for reducing interaction noise (2018)

&lt;p&gt;Reducing aircraft noise has become a significant political issue over the last decade, with the establishment of more demanding regulations concerning noise emissions. Aerofoil-Turbulence Interaction noise is an inviscid phenomenon generated by the impingement of turbulent flows on the leading-edge of an aerofoil. Occurring during the interaction of the turbulent wakes from the rotor with the outlet guide vanes, ATI noise is believed to be the dominant broadband noise source on modern turbofan engines. A recent experimental study has shown the increased effectiveness of new innovative leading edge profiles for reducing ATI noise, in comparison to conventional sinusoidal or sawtooth profiles. Slitted leading-edges have been identified by far as the most effective geometry that has been tested in terms of noise reductions. This present project focuses on the investigation of these novel leading-edge geometries through a numerical approach and aims at understanding the noise reduction mechanisms in order to further optimize the serration geometries. In this study, a flat-plate in a uniform mean flow is numerically being impacted by vortical perturbations, modelled by a single spanwise vortex injected upstream of the aerofoil. The computational work is realised based on an optimized high-order finite difference solver, solving the full 3D compressible Euler equations in time-domain. Results concerning the surface pressure fluctuations generated on the flat-plate are being analysed and compared to results obtained with a straight LE. A special focus is laid on the identification of noise reduction mechanisms involved in the use of these particular serration profiles.&lt;/p&gt;
Ancient and new algorithms for load balancing in the Lp norm (1998)

We consider the on-line load balancing problem where there are m identical machines (servers) and a sequence of jobs. The jobs arrive one by one and should be assigned to one of the machines in an on-line fashion. The goal is to minimize the sum (over all machines) of the squares of the loads, instead of the traditional maximum load.