gebhart/patrepeval huggingface dataset:
In Vivo Tibiofemoral Kinematics During 4 Functional Tasks of Increasing Demand Using Biplane Fluoroscopy (2011)

This study demonstrated that while ATT will increase as demand on the quadriceps and external loading increases, the knee is able to effectively constrain ATT and internal rotation. This suggests that the healthy knee has a safe envelope of function that is tightly controlled even though task demand is elevated.
Current controller considering harmonics compensation for grid connected converter in DPGS applications (2012)

This paper deals with the design and implementation of PR current control method in the αβ stationary reference frame for the grid side converter in Distributed Power Generation Systems (DPGS) applications. The goals of this paper are to implement a control technique for the grid side inverter including a LC filter, a compensation technique for low-order harmonics and to examine the grid current harmonic content with and without harmonic compensation. A comparative study in terms of current harmonic distortion between two different values of PR proportional gain running in steady state condition is made. The analyzed structure was simulated with Simulink software, then implemented and tested in laboratory using a dSPACE setup. The parameters of the system can be set according to the used experimental setup to validate the simulation results.
State estimation for aggressive flight in GPS-denied environments using onboard sensing (2012)

In this paper we present a state estimation method based on an inertial measurement unit (IMU) and a planar laser range finder suitable for use in real-time on a fixed-wing micro air vehicle (MAV). The algorithm is capable of maintaing accurate state estimates during aggressive flight in unstructured 3D environments without the use of an external positioning system. Our localization algorithm is based on an extension of the Gaussian Particle Filter. We partition the state according to measurement independence relationships and then calculate a pseudo-linear update which allows us to use 20x fewer particles than a naive implementation to achieve similar accuracy in the state estimate. We also propose a multi-step forward fitting method to identify the noise parameters of the IMU and compare results with and without accurate position measurements. Our process and measurement models integrate naturally with an exponential coordinates representation of the attitude uncertainty. We demonstrate our algorithms experimentally on a fixed-wing vehicle flying in a challenging indoor environment.
Longitudinal effects on plasma abeta levels of imatinib, a gamma-secretase activating protein inhibitor (2013)

Imatinib Mesylate is a competitive tyrosine-kinase inhibitor used in the treatment of multiple types of leukaemia, including Ph+ chronic myelogenous leukaemia (CML). The recent report that Imatinib inhibits gamma-secretase activating protein (gSAP), reducing beta-amyloid- (Abeta) production without affecting Notch-1 cleavage has led to the proposal of a possible application of this drug in AD therapeutics. In fact, one major drawback of Semagacestat, a direct inhibitor of gamma-secretase, was identified in the low Abeta/Notch therapeutic index, with the consequent failure of the phase III trial. Imatinib peripheral administration (20 mg/kg/day) was able to reduce Abeta content in mouse brain. Usually, leukaemia patients receive an average oral dose of 400 mg/day (∼5–6 mg/kg/day). In this longitudinal study we investigated if Imatinib administration in 10 leukemic patients could reduce plasma Abeta1–40 levels. Patients’ blood was sampled prior to treatment (time T0) and after 15, 30, and 60-to-90 days of treatment. Abeta1–40 plasma levels were assessed by ELISA as previously described. No significant reduction in plasma Abeta1–40 was observed at any time point. In fact, ratios to T0 of Abeta1–40 T15-, T30- and T90 were: 1.07 ± 0.39, 1.37 ± 0.59, and 1.48 ± 0.61, respectively, indicating no decrease with Imatinib. While these results are negative at standard dosing of Imatinib for CML, they do not exclude the possibility that Abeta lowering effects might be present at higher doses of this drug or with second generation tyrosine-kinase inhibitors, such as Dasatinib or Nilotinib, which can cross the blood brain barrier more easily. Further exploration of this issue might lead to advances in AD therapeutics
Low-Footprint Optical Interconnect on an SOI Chip Through Heterogeneous Integration of InP-Based Microdisk Lasers and Microdetectors (2009)

We present a proof-of-principle demonstration of a low-footprint optical interconnect on a silicon-on-insulator (SOI) chip. The optical link consists of a heterogeneously integrated, InP-based microdisk laser (MDL) and microdetector, coupled to a common SOI wire waveguide. Applying an electrical current to the MDL resulted in a detector current up to 1 muA.
Gülenist Kültte Kadın İmgesi (2020)

Kadın konusu dinî yapıların birçoğunda sorunlu bir alan olarak karşımıza çıkar. Ataerkil ve geleneksel toplumlarda kadının kamusal ve toplumsal rolü birçok çalışmaya konu olmuştur. Buna karşılık hem Türkiye’de hem de Batı’da oldukça popüler olan ve geniş bir cemaat ağı bulunan Fethullah Gülen Hareketi birçok açıdan modern toplum ve demokratik değerlerle daha uyumlu bir yapı olarak kabul ediliyordu. 15 Temmuz darbe girişimiyle birlikte Türk kamuoyunda Gülen vecemaatine ilişkin görüşlerin çoğu değişmiş olsa da Batı kamuoyu için aynı şeyi söylemek pek mümkün gözükmüyor. Özellikle de Gülen’in metinlerinde ne dediğini ve söylediklerinin teo-politik dilini anlamaksızın sosyolojik bakışla ele alınan çalışmalarda Gülen’in kadının toplumsalrolü konusunda geleneksel görüşlerden çok farklı bir söyleme sahip olduğu iddia edilmiştir.Bu çalışmada doğrudan Gülen’in dinî söylemine eğilerek, kadın konusundaki yorumlarının teo-politik bağlamını, Gülen söyleminin İslam’ın çoğul yorumlarından hangisine denk düştüğünü ve en önemlisi onun dinî politik yorumları ile cemaatinin hiyerarşik yapısı arasındaki ilişkiyi açıklamaya çalışacağız. Çünkü Gülen’in kurduğu organizasyonlar ve hiyerarşiler (bunu üst yapı olarak adlandırabiliriz) ile dinî ideolojik yorumları (bunu da alt yapı olarak isimlendirmek mümkün) arasındadoğrudan bir ilişki vardır. Bu ilişki aslında birçok dinî-örgütsel yapılar için de düşünülebilir. Çünkü her örgütü bir arada tutan, amaç ve eylemlerini meşrulaştıran bir ideolojisi vardır. Sorun bu ideoloji ile örgütsel organizasyon arasında nasıl bir ilişki olduğunun açıklanmasıdır. Kadın sorununun bunun için oldukça elverişli bir tartışma olduğunu düşünüyoruz.
Physical key extraction attacks on PCs (2016)

Computers broadcast their secrets via inadvertent physical emanations that are easily measured and exploited.
Attending to What Matters (2019)

Online services are increasingly intelligent. They evolve intelligently through A/B testing and experimentation, employ artificial intelligence in their core functionality using machine learning, and seamlessly engage human intelligence by connecting people in a low-friction manner. All of this has resulted in incredibly engaging experiences -- but not particularly productive ones. As more and more of people's most important tasks move online we need to think carefully about the underlying influence online services have on people's ability to attend to what matters to them. There is an opportunity to use intelligence for this to do more than just not distract people and actually start helping people attend to what matters even better than they would otherwise. This presentation explores the ways we might make it as compelling and easy to start an important task as it is to check social media.
Glucose consumption of inflammatory cells masks metabolic deficits in the brain (2015)

Inflammatory cells such as microglia need energy to exert their functions and to maintain their cellular integrity and membrane potential. Subsequent to cerebral ischemia, inflammatory cells infiltrate tissue with limited blood flow where neurons and astrocytes died due to insufficient supply with oxygen and glucose. Using dual tracer positron emission tomography (PET), we found that concomitant with the presence of inflammatory cells, transport and consumption of glucose increased up to normal levels but returned to pathological levels as soon as inflammatory cells disappeared. Thus, inflammatory cells established sufficient glucose supply to satisfy their energy demands even in regions with insufficient supply for neurons and astrocytes to survive. Our data suggest that neurons and astrocytes died from oxygen deficiency and inflammatory cells metabolized glucose non-oxidatively in regions with residual availability. As a consequence, glucose metabolism of inflammatory cells can mask metabolic deficits in neurodegenerative diseases. We further found that the PET tracer did not bind to inflammatory cells in severely hypoperfused regions and thus only a part of the inflammation was detected. We conclude that glucose consumption of inflammatory cells should be taken into account when analyzing disease-related alterations of local cerebral metabolism.
Cyst formation in the PKD2 (1-703) transgenic rat precedes deregulation of proliferation-related pathways (2010)

Our data suggest that cystogenesis precedes deregulation of proliferation-related pathways, suggesting that proliferation abnormalities may contribute in cyst growth rather than cyst formation.
Electrode influence on the transport through SrRuO3∕Cr-doped SrZrO3/metal junctions (2007)

The authors have investigated the charge transport properties across heterostructures built from a SrRuO3 bottom electrode, a Cr-doped SrZrO3 perovskite film, and different top electrode metals (Pt, Cu, Ag, Cr, Mg, and SrRuO3). The resistances of such junctions were dependent on the top metal and ranging between 1 and 1000kΩ. The observed I-V curves were modeled with the equation I(V)=aV+bV2, where the variation of a with metal type was related to the work function while the variation of b was related to the oxygen affinity of the metal, consistent with space charge limited conduction through a defected interface.
Multipurpose setup used to characterize tribo-electrical properties of electrical contact materials (2021)

Electrical contacts are pervasively found on countless modern devices and systems. It is imperative that connecting components present adequate electrical, mechanical, and chemical characteristics to fulfill the crucial role that they play in the system. To develop an electrical contact material that is tailored for a specific application, different approaches are pursued (e.g., coatings, reinforced composites, alloyed metals, duplex systems, etc.). The manufacturing of electrical contact materials demand a thorough characterization of their electrical properties, mechanical properties, and their resistance to wear, as well as their resistance to atmospheric conditions. Accordingly, commissioning of a novel setup enables a more comprehensive study of the materials that are developed. Therefore, a complete understanding of the material's electrical and tribological characteristics are attained, allowing the production of a material that is compliant with the particular demands of the application for which it is intended. This multipurpose setup was built with higher precision stages and higher accuracy 3-axis force sensor, thus providing the following improvement over the preceding setup:•Elevated load-bearing capacity (double), higher precision and stability.•Tribo-electrical characterization (implementation of scratch and fretting tests).•Environmental control (climate and external vibration).
Long-term Maintenance of Remission with No Dose Escalation After Reinduction with Certolizumab Pegol in Patients with Crohnʼs Disease Exacerbation: 3-year Results from the PRECiSE 4 Study (2009)

Purpose: Long-term data on therapeutic strategies that aim to recapture patients with relapsed Crohn's disease (CD) are lacking. Here we report the long-term (3-year) efficacy and safety of certolizumab pegol (CZP) in patients who, after initial response to CZP induction, experienced disease exacerbation on either active or placebo maintenance therapy in PRECiSE 2 (P2). Patients were re-induced with CZP, or in the case of those on active treatment given 1 single extra dose, and then continued with q4w maintenance therapy in PRECiSE 4 (P4). Methods: In the P2 study, 428 patients who responded to induction therapy with CZP at Week 6 were randomized to continuous therapy with CZP or placebo (drug interruption) during weeks 6-26. Patients who had an exacerbation of symptoms before Week 26 could enter P4, an open-label extension study. In P4, patients received CZP 400 mg at Weeks 0, 2, and 4 followed by q4w maintenance therapy with CZP 400 mg through Week 156 (3 years). Disease activity was measured using the Harvey Bradshaw Index (HBI). Here we examine the sustainability of remission (total HBI score of ≤4 points) in patients who were in remission at Week 4 of P4. Results: Of the 124 patients who entered P4, 36% (n=45) achieved remission by Week 4. After 1, 2, and 3 years of q4w CZP 400 mg maintenance therapy, remission was maintained in 56% (n=25/45); 42% (n=19/45) and 27% (n=12/45) of patients, respectively. Remission rates for those who remained in the study and provided data at 1, 2, and 3 years (i.e., observed case analysis) were 69% (25/36), 76% (19/25), and 67% (12/18), respectively. Rates of remission were similar in the continuous exposure and drug interruption groups. No new safety concerns were identified. Conclusion: Over two-thirds of patients who were recaptured with re-induction and maintained on q4w dosing were in remission at any observed point during the 1-, 2-, and 3-year treatment period. These data suggest that a long-term benefit is achieved with a re-induction strategy in patients with CD who lost response due to drug interruption or loss of initial response to active therapy with no dose escalation. Disclosure: Dr Sandborn is a consultant for UCB; Dr Schreiber is a consultant for UCB; Dr Hanauer is a consultant for UCB; Dr Colombel is a consultant for UCB; Mr Bloomfield is an emplyee of UCB; Dr Lichtenstein is a consultant for UCB. This research was supported by an industry grant from UCB.Table
Modifying the Surface of a High-Voltage Lithium-Ion Cathode (2018)

Ni-rich lithium nickel manganese cobalt oxides (LiNixMnyCo1–x–yO2, NMCs) suffer from poor cycling stability at potentials above 4.2 V vs Li/Li+. This degraded cyclability at high potentials has been largely ascribed to the parasitic reactions between the delithiated cathode and the nonaqueous electrolyte. In this study, we mitigated the performance degradation of high-voltage NMC 622 by designing a functional interfacial layer that consists of a surface doping by Ti4+ and a TiO2 coating at the same time. The doping of Ti4+ near the surface of NMC can suppress the irreversible phase transformation, while the TiO2 coating can kinetically reduce the rate of the electron-transfer reaction between the delithiated cathode and the solvent. It is revealed that this interfacial engineering approach significantly enhanced both the cycling stability and the rate performance of NMC 622.
An Iterative Decoded V-BLAST System using Maximum a Posteriori Criterion (2004)

This paper contains our proposal for a new decoding algorithm for an iterative decoded V-BLAST system. The proposed algorithm is based on maximum a posteriori (MAP) decision criterion. In a V-BLAST system concatenated with channel coding, the extrinsic information from the soft output channel decoder can be utilized as a priori probability, making it possible to apply MAP decision criteria to the V-BLAST decoding process. The MAP decision criterion is applied to the V-BLAST ordering and slicing procedure, resulting in a considerable gain in bit error performance. As the iteration rate increases, the proposed system exhibits performance similar to that of systems with ideal sliced.
Multi-Objective Optimization of a Path-following MPC for Vehicle\n Guidance: A Bayesian Optimization Approach (2021)

This paper tackles the multi-objective optimization of the cost functional of\na path-following model predictive control for vehicle longitudinal and lateral\ncontrol. While the inherent optimal character of the model predictive control\nand the direct consideration of constraints gives a very powerful tool for many\napplications, is the determination of an appropriate cost functional a\nnon-trivial task. This results on the one hand from the number of degrees of\nfreedom or the multitude of adjustable parameters and on the other hand from\nthe coupling of these. To overcome this situation a Bayesian optimization\nprocedure is present, which gives the possibility to determine optimal cost\nfunctional parameters for a given desire. Moreover, a Pareto-front for a whole\nset of possible configurations can be computed.\n
ChemInform Abstract: PHOSPHINE OXIDES AND LITHIUM ALUMINUM HYDRIDE‐SODIUM BOROHYDRIDE‐CERIUM(III) CHLORIDE: SYNTHESIS AND REACTIONS OF PHOSPHINE‐BORANES (1985)

Abstract Unter der angegebenen Bedingung reagieren die Phosphinoxide (I) glatt zu den Phosphin‐Boranen (III), während in Abwesenheit von CeCl 3 keine Reaktion stattfindet.
Photolysis of bisphenol‐based polyurethanes in solution (1999)

Photolysis of bisphenol-based polyurethanes, using bisphenols A, S, and AF with methylene diphenyl diisocyanate (MDI), has been shown by the observed changes in fluorescence spectra, reduced viscosity, and UV absorbance. Analysis of the fluorescence spectra of model compounds and polymers showed that para-photo-Fries and cleavage-type products were the major components formed during photolysis. The reduced viscosity and UV absorbance changes are consistent with a two-step photodegradation process. The reduced viscosity changes indicate that oxygen inhibition on the cleavage process is more significant for bisphenol S-based polyurethanes than for bisphenol A- and bisphenol AF-based polyurethanes. © 1999 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 37: 1331–1339, 1999
Phase-Transfer-Catalyzed Asymmetric Glycolate Alkylation (2004)

[reaction: see text] Asymmetric surrogate glycolate alkylation has been performed under phase-transfer conditions. Diphenylmethyloxy-2,5-dimethoxyacetophenone with trifluorobenzyl cinchonidinium catalyst and cesium hydroxide provided alkylation products at -35 degrees C in high yield (80-99%) and with excellent enantioselectivities (90:10 to 95:5). Useful alpha-hydroxy products were obtained using bis-TMS peroxide Baeyer-Villiger conditions and selective transesterification. The intermediate aryl ester can be obtained with >99% ee after a single recrystallization. A tight ion-pair model for the observed (S)-stereoinduction is proposed.
A prospective, randomized study to evaluate dermal closure with an absorbable barbed suture as compared to a conventional absorbable suture: Interim analysis (2011)

Capla, Jennifer M. MD; Dunn, Raymond M. MD; Gusenoff, Jeffrey MD; Hansen, Juliana MD; Hunstad, Joseph MD; Polynice, Alain MD; Schoeller, Thomas MD; Walgenbach, Klaus MD; Rubin, Peter J. MD, FACS Author Information
Endocrine Abnormalities in Patients with Fanconi Anemia (2007)

Endocrine dysfunction is widespread in children and adults with FA; we expand the FA phenotype to include early onset osteopenia/osteoporosis and lipid abnormalities. Despite the reputation of FA as a progressive, lethal disease, proper management of the full spectrum of FA-related endocrinopathy offers major opportunities to reduce morbidity and improve quality of life. Our findings emphasize the need for comprehensive endocrine and metabolic evaluation and long-term follow-up in patients with FA.
Reach extension in 10-Gb/s directly modulated transmission systems using asymmetric and narrowband optical filtering (2005)

Optical filtering has been used to extend the reach of directly modulated laser in 10Gb/s WDM systems via two separate mechanisms: narrowing the broadened spectrum, and converting frequency modulation into useful amplitude modulation. We investigate in detail, the impact of asymmetric and narrowband optical filtering at the transmitter or receiver. Experimental demonstrations for both shorter distance and long-haul like transmission using optical filtering are performed. The transmission reach is nearly doubled from <25-km to >45-km without dispersion compensation. 1400-km error-free transmission (Q > 15.6-dB) is further achieved over dispersion-managed link for a directly modulated DFB laser within an 8x10-Gb/s WDM system.
Maturation of the tail spike endorhamnosidase of Salmonella phage P22. (1982)

As part of a genetic analysis of the in vivo folding and subunit assembly of the P22 tail spike endorhamnosidase, we have studied the maturation of the newly synthesized 76,000-dalton polypeptide chains into thermostable tail spike oligomers. Four of 15 temperature-sensitive mutations in the structural gene for this protein result in electrophoretically distinct tail spikes. Cells mixedly infected with wild type and an electrophoretic variant produce two hybrid species, with mobilities intermediate between the parental species, indicating that the native tail spike is a trimer. Mature trimers are resistant to denaturation by sodium dodecyl sulfate (SDS): at room temperature the trimer migrates in an SDS gel as if it were not binding significant amounts of SDS, whereas the heat-denatured chain migrates as expected of an SDS-polypeptide complex. The mature trimer is also resistant to trypsin digestion. Lysates of infected cells contain SDS and trypsin-sensitive forms of the newly synthesized tail spike polypeptide chains. These are probably incompletely or incorrectly folded chains. SDS and trypsin resistance were used to measure the efficiency of in vivo folding and subunit assembly of the mature trimer from its polypeptide chains. This decreased from 90% at 27 degrees C to only 15% at 42 degrees C. These results are consistent with the existence or a labile intermediate or step in the folding or subunit assembly of the thermostable tail spike protein. We discuss the possibility that the achievement of certain structural features of mature proteins may entail difficulties in their folding pathways.
Super-Robust, Lightweight, Conducting Carbon Nanotube Blocks Cross-Linked by De-fluorination (2008)

We produced large binder-free multi-walled carbon nanotube (MWNT) blocks from fluorinated MWNTs using thermal heating and a compressing method in vacuo. This technique resulted in the formation of covalent MWNT networks generated by the introduction of sp(3)-hybridized carbon atoms that cross-link between nanotubes upon de-fluorination. The resulting carbon nanotube blocks are lighter than graphite, can be machined and polished, and possess average bending strengths of 102.2 MPa, a bending modulus of 15.4 GPa, and an electrical conductivity of 2.1 x 10(2) S/cm. Although each nanotube exhibits a random structure in these blocks, the mechanical properties are 3 times higher than those obtained for commercial graphite. On the basis of theoretical molecular dynamics simulations, a model is presented for the nanotube interconnecting mechanism upon de-fluorination.
COMBINED TREATMENT WITH AN IL-15 MUTANT /Fc PROTEIN AND CTLA4/Fc ALLOWS PERMANENT ENGRAFTMENT. (2000)

Lacraz, Sylvie Ferrari1; Zheng, Xin Xiao1; Kim, Yon Su1; Maslinski, Wlodzimierz1; Strom, Terry B.1 Author Information