gebhart/patrepeval huggingface dataset:
Early experience with a repository for patterned injury data (1995)

We have constructed a proof-of-principle system called the repository for patterned injury data (RPID) for supporting collaborative forensic medicine. The early RPID prototype is built on ABC/DGS, a graph-server and collaborative hypermedia system built in the UNC Collaboratory. ABC provides collaboration services for work groups via shared artifacts, giving common views of the information and allowing conferencing over the data. A second prototype is underway that has more flexible control of multiperson creation of, and access to, the shared patient data and pathology artifacts. We conclude by describing a planned third prototype, to be built not on ABC, but on a modification of the WWW httpd distribution data server.
Enhanced Graphene Sensors via Multi-Lasing Fabrication (2021)

Resistive strain and bending sensors offer a versatile platform for sensing various physical parameters with relatively little effort and budget. The lightweight, robust and compact sensors are extensively used in manifold low-power applications. Recently, scribed and flexible laser-induced graphene sensors have shown potent capabilities for a variety of measurements, including flow, deflection, and force. Achieving a high sensitivity to various stimuli remains a challenge due to limited change in relative resistance. In this paper, we report a multifunctional LIG sensor with widely tunable properties and significantly enhanced electromechanical performance. A method of repeated laser writing is used to increase the porosity, the uniform carbonization degree and, most importantly, the sensitivity of the LIG sensors. A gauge factor of 91.2 is achieved after three-times laser writing at low power, which is an increase of 750% to one-time laser writing and 720% higher than the ones previously reported for LIG strain sensors. The increase is attributed to a more porous surface morphology that provides more overlapping area and displacement of the graphene layers. A homogeneous bidirectional response was obtained by scribing the electrodes on both faces of the substrate. Parylene C-coating is used to protect the LIG sensors from environmental effects. Coated sensors were packaged to a PCB assembly for easy integration into various applications. An example is a LIG bending sensor customized for velocity profile monitoring of Unmanned Aerial Vehicles in the outdoor environment.
Familial Replicating Arachnoidal Cysts: Case Series and Review of Literature (2015)

Background:throughout the cerebrospinal axis.Although the precise causative mechanism is unknown, arachnoid cyst (AC) are now generally accepted to be developmental anomalies of arachnoid.These lesions have commonly been described in the literature; however the presence of familial arachnoid cysts is quite rare.Most genetically related AC have been documented in patients with a known genetic syndrome.The current case report describes a family with four members affected by an arachnoid cyst in the same region. Methods:In addition to reviewing the current case, a literature search was conducted using National Library of Medicine and National Institutes of Health databases to identify articles pertaining to familial Arachnoid cysts.Overall, Results:We describe a family whose members (father and three siblings) present an arachnoid cyst in the same Histories of prenatal and perinatal periods were unremarkable.All were born normally at term and none had any history of intrauterine exposure to infection, drugs, teratogens or trauma.Karyotyping failed to reveal abnormalities. Conclusion:This report extends previous observations that AC can be familial and supports the hypothesis that some cases have a genetic aetiology.The lack of chromosomal or genetic studies in these patients supports the need for additional research into the mechanism of AC formation.
Supplemental legend from Immunotherapy Targeting HPV16/18 Generates Potent Immune Responses in HPV-Associated Head and Neck Cancer (2023)

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Safety and Efficacy of Iron Supplementation After Myocardial Infarction in Mice with Moderate Blood Loss Anaemia (2021)

Iron supplementation 24 h after reperfusion of AMI is safe and reversed enlargement of end-systolic volume after AMI resulting in increased stroke volume and cardiac output. This highlights its potential as adjunctive treatment in anaemia with ID after reperfused AMI. Time point of iron application after reperfusion appears critical.
Cemiplimab (REGN2810), a Fully Human Anti-PD-1 Monoclonal Antibody, for Patients with Unresectable Locally Advanced or Metastatic Cutaneous Squamous Cell Carcinoma: Initial Safety and Efficacy from Expansion Cohorts of Phase 1 Study (2018)

Abstract not available. Disclosures: Study sponsored by Regeneron Pharmaceuticals Inc. and Sanofi. Copyright 2018 SKIN
An open source analysis framework for large-scale building energy modeling (2020)

Full integration of building energy modelling into the design and retrofit process has long been a goal of building scientists and practitioners. However, significant barriers still exist. Among them are the lack of available: (1) configurable technology stacks for performing both small- and large-scale analyses, (2) different classes of algorithms compatible with common design workflows, and (3) analysis tools for effectively visualizing large-scale simulation results. This article discusses the OpenStudio® Analysis Framework: a scalable analysis framework for building energy modelling that was developed to overcome the three barriers listed above. The framework is open-source and scalable to facilitate wider adoption and has a clearly defined application programming interface upon which other applications can be built. It runs on high-performance computing systems, within cloud infrastructure, and on laptops, and uses a common workflow to enable different classes of algorithms. Lessons learned from previous development efforts are also discussed.
Practical Design Considerations for Contactless Power Transfer Quadrature Pick-Ups (2011)

This paper presents a practical prototype of a recent multiphase (quadrature) pick-up suited for contactless power transfer systems. The investigation is based on a commercial pick-up design for automatic guided vehicle systems and is evaluated in terms of its ability to extend the allowable tolerance of this pick-up receiver to the track while achieving the desired output power profile with good efficiency, without compromising normal operation. Practical aspects of the design are discussed along with means by which magnetic design and electronic compensation can be used to improve performance.
Broadcast technologies for disseminating cultural heritage (2001)

This paper introduces the System for Advanced Multimedia Broadcast and IT Services (SAMBITS). It consists of a Studio, Server and TV Terminal system for broadcasting audio/video TV content enhanced by 3D graphics, Internet pages, database indexing and sub-image streaming. It describes two scenarios program for disseminating cultural heritage. The readers are invited to imagine how this system could be used to prepare programs for disseminating archaeology. The paper describes the Studio and Server Tools and the main functionality of the TV terminal. It describes the functionality of the terminal through the description of the scenario in conjunction with illustrative screen shots.
X-Ray Resonant Raman Spectra of Several Copper Compounds (1994)

Resonant effect in X-ray Raman spectra of various copper(I) and copper(II) compounds was studied by using tunable X-rays from synchrotron radiation. Prominent excitation energy dependence in spectral shape as well as in intensity was observed and analyzed in terms of simple equations derived from Kramers-Heisenberg equation. Anomaly in spectral shape was observed for Cu(II) compounds and it is ascribed to existence/nonexistence of a vacant 3d orbital in Cu(II)/Cu(I) compounds.
Magnetoresistance of ferromagnetic multiple-wire system (1999)

Artificially patterned magnets such as ferromagnetic dots and wire my are an ideal system for the investigation of magnetization reversal process accompanying with the magnetic wall propagation [1,2]. Magnetization process of multiple Fe-Ni wires system was studied by measuring the electric resistance. In a very narrow ferromagnetic wire, the magnetization is restricted to be directed either parallel or antiparallel to the wire axis.
Pulmonary microvascular response to LTB4: effects of perfusate composition (1988)

We examined the effects of leukotriene B4 (LTB4) on pulmonary hemodynamics and vascular permeability using isolated perfused guinea pig lungs and cultured monolayers of pulmonary arterial endothelial cells. In lungs perfused with Ringer solution, containing 0.5 g/100 ml albumin (R-alb), LTB4 (4 micrograms) transiently increased pulmonary arterial pressure (Ppa) and capillary pressure (Pcap). Pulmonary edema developed within 70 min after LTB4 injection despite a normal Pcap. The LTB4 metabolite, 20-COOH-LTB4 (4 micrograms), did not induce hemodynamic and lung weight changes. In lungs perfused with autologous blood hematocrit = 12 +/- 1%; protein concentration = 1.5 +/- 0.2 g/100 ml), the increases in Ppa and Pcap were greater, and both pressures remained elevated. The lung weight did not increase in blood-perfused lungs. In lungs perfused with R-alb (1.5 g/100 ml albumin) to match the blood perfusate protein concentration, LTB4 induced similar hemodynamic changes as R-alb (0.5 g/100 ml) perfusate, but the additional albumin prevented the pulmonary edema. LTB4 (10(-11)-10(-6) M) with or without the addition of neutrophils to the monolayer did not increase endothelial 125I-albumin permeability. Therefore LTB4 induces pulmonary edema when the perfusate contains a low albumin concentration, but increasing the albumin concentration or adding blood cells prevents the edema. The edema is not due to increased endothelial permeability to protein and is independent of hemodynamic alterations. Protection at higher protein-concentration may be the result of LTB4 binding to albumin.
User Taglines: Alternative Presentations of Expertise and Interest in Social Media (2012)

Web applications are increasingly showing recommended users from social media along with some descriptions, an attempt to show relevancy - why they are being shown. For example, Twitter search for a topical keyword shows expert twitterers on the side for 'whom to follow'. Google+ and Facebook also recommend users to follow or add to friend circle. Popular Internet newspaper- The Huffington Post shows Twitter influencers/ experts on the side of an article for authoritative relevant tweets. The state of the art shows user profile bios as summary for Twitter experts, but it has issues with length constraint imposed by user interface (UI) design, missing bio and sometimes funny profile bio. Alternatively, applications can use human generated user summary, but it will not scale. Therefore, we study the problem of automatic generation of informative expertise summary or taglines for Twitter experts in space constraint imposed by UI design. We propose three methods for expertise summary generation- Occupation-Pattern based, Link-Triangulation based and User-Classification based, with use of knowledge-enhanced computing approaches. We also propose methods for final summary selection for users with multiple candidates of generated summaries. We evaluate the proposed approaches by user-study using a number of experiments. Our results show promising quality of 92.8% good summaries with majority agreement in the best case and 70% with majority agreement in the worst case. Our approaches also outperform the state of the art up to 88%. This study has implications in the area of expert profiling, user presentation and application design for engaging user experience.
The process trellis: a software architecture for intelligent monitors (2003)

The process trellis software architecture aids the programmer in building intelligent monitors for hierarchical domains by providing a way to guarantee real-time performance, structuring the interactions between modules, guiding the decomposition of the computation, and providing a well-defined interface with the external world. There is a natural parallel execution strategy for these decision processes which enables programs that would otherwise be unable to meet their real-time constraints to do so and permits speedup of programs without real-time constraints. One way to demonstrate a software architecture's utility is by an existence proof; HEARSAY-II is such a proof for blackboard architectures. While still a research project, a process trellis shell, which implements most of the features of the process trellis software architecture, is being used for an intelligent cardiovascular monitor that is intended for eventual use in a cardiac intensive care unit.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A Joint Computational and Experimental Evaluation of CaMn2O4 Polymorphs as Cathode Materials for Ca Ion Batteries (2016)

The identification of potential cathode materials is a must for the development of a new calcium-ion based battery technology. In this work, we have first explored the electrochemical behavior of marokite–CaMn2O4 but the experimental attempts to deinsert Ca ion from this compound failed. First-principles calculations indicate that in terms of voltage and capacity, marokite–CaMn2O4 could sustain reversible Ca deinsertion reactions; half decalciation is predicted at an average voltage of 3.7 V with a volume variation of 6%. However, the calculated barriers for Ca diffusion are too high (1 eV), in agreement with the observed difficulty to deinsert Ca ion from the marokite structure. We have extended the computational investigation to two other CaMn2O4 polymorphs, the spinel and the CaFe2O4 structural types. Full Ca extraction from these CaMn2O4 polymorphs is predicted at an average voltage of 3.1 V, but with a large volume variation of around 20%. Structural factors limiting Ca diffusion in the three polymorphs are discussed and confronted with a previous computational investigation of the virtual-spinel [Ca]T[Mn2]OO4. Regardless the potential interest of [Ca]T[Mn2]OO4 as cathode for Ca ion batteries, calculations suggests that the synthesis of this compound would hardly be feasible. The present results unravel the bottlenecks associated with the design of feasible intercalation Ca electrode materials, and allow proposing guidelines for future research.
The feasibility and value of low-frequency data collected using colocated 2-Hz and 10-Hz geophones (2013)

ConocoPhillips acquired a production 3D surface seismic survey in 2010. The survey size was about 410 square miles recorded by 10-Hz geophones with INOVA 364 vibrators that are capable of sweeping from 1 to 150 Hz. In addition, we carried out a field experiment recording a swath of 3D surface seismic data with colocated 2-Hz and 10-Hz geophones. The cost of acquiring the 2-Hz geophone data was negligible when compared with the cost of the entire 3D survey. Because the vibrators can produce energy down to 2 Hz, the use of the 2-Hz geophone is crucial in capturing this energy. To our knowledge, this was the first field experiment employing the 2-Hz geophones and vibrators that could transmit enough low-frequency signals into the ground. The questions we investigate in this field experiment are: (1) how much low-frequency signal can be recorded using 2-Hz geophones, (2) how much degradation of low-frequency signal results from the 10-Hz geophones when compared to the 2-Hz geophones, and (3) the possibility of using the colocated data sets to enhance the low-frequency signal of 10-Hz geophone data that include both experimental and production data. The analyses of the 10-Hz and 2-Hz geophone data in prestack and poststack domains concluded that 2-Hz geophone data clearly exhibited more low-frequency signal than the 10-Hz geophone data. The 2-Hz geophone stack had low-frequency signal down to 2 Hz, and a spiking deconvolution further extended the amplitude spectrum down to 1 Hz. In addition, we develop a novel technique to derive a deterministic match filter from the colocated data sets. The application of this filter on the 10-Hz geophone data recovers the low-frequency signal below 10 Hz.
Whole genome genotyping technologies on the BeadArray™ platform (2007)

The ability to simultaneously genotype hundreds of thousands of single-nucleotide polymorphisms (SNPs) in a single assay has recently become feasible due to innovative combinations of assay and array platform multiplexing. In this review, we describe the development of the Infinium whole genome genotyping technology and the BeadArray platform. We discuss the automated use and performance of a series of genotyping BeadChips, including data quality, technology scalability, and flexibility in designing array content. We describe high-density tag SNP-based Bead-Chips and various multi-sample BeadChip configurations with their respective applications. These technologies are enabling large-scale whole genome association studies that have the potential to revolutionize our ability to detect common genetic variants with a significant role in identifying disease-associated loci, proteins, biomarkers, and pharmacogenomic responses.
Large-mode-area single-mode holey fiber with low bending losses: Towards high power beam delivery systems (2007)

We propose a novel design method for large-mode-area single-mode holey fiber with effective mode area of 1400 μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , small allowable bending radius of 5 cm, and good beam quality factor of 1.15 at 1.064-μm wavelength.
Aminoquinoline Surfen Inhibits the Action of SEVI (Semen-derived Enhancer of Viral Infection) (2009)

In semen, proteolytic peptide fragments from prostatic acid phosphatase can form amyloid fibrils termed SEVI (semen-derived enhancer of viral infection). These fibrils greatly enhance human immunodeficiency virus (HIV) infectivity by increasing the attachment of virions to target cells. Therefore, SEVI may have a significant impact on whether HIV is successfully transmitted during sexual contact. Here, we demonstrate that surfen, a small molecule heparan sulfate proteoglycan antagonist, inhibits both SEVI- and semen-mediated enhancement of HIV type 1 infection. Surfen interferes with the binding of SEVI to both target cells and HIV type 1 virions but does not deaggregate SEVI fibrils. Because SEVI can increase HIV infectivity by several orders of magnitude, supplementing current HIV microbicide candidates with SEVI inhibitors, such as surfen, might greatly increase their potency.
Invariant structural and functional brain regions associated with tinnitus: A meta-analysis (2022)

Tinnitus is a common, functionally disabling condition of often unknown etiology. Neuroimaging research to better understand tinnitus is emerging but remains limited in scope. Voxel-based physiology (VBP) studies detect tinnitus-associated pathophysiology by group-wise contrast (tinnitus vs controls) of resting-state indices of hemodynamics, metabolism, and neurovascular coupling. Voxel-based morphometry (VBM) detects tinnitus-associated neurodegeneration by group-wise contrast of structural MRI. Both VBP and VBM studies routinely report results as atlas-referenced coordinates, suitable for coordinate-based meta-analysis (CBMA). Here, 17 resting-state VBP and 8 VBM reports of tinnitus-associated regional alterations were meta-analyzed using activation likelihood estimation (ALE). Acknowledging the need for data-driven insights, ALEs were performed at two levels of statistical rigor: corrected for multiple comparisons and uncorrected. The corrected ALE applied cluster-level inference thresholding by intensity (z-score > 1.96; p < 0.05) followed by family-wise error correction for multiple comparisons (p < .05, 1000 permutations) and fail-safe correction for missing data. The corrected analysis identified one significant cluster comprising five foci in the posterior cingulate gyrus and precuneus, that is, not within the primary or secondary auditory cortices. The uncorrected ALE identified additional regions within auditory and cognitive processing networks. Taken together, tinnitus is likely a dysfunction of regions spanning multiple canonical networks that may serve to increase individuals' interoceptive awareness of the tinnitus sound, decrease capacity to switch cognitive sets, and prevent behavioral and cognitive attention to other stimuli. It is noteworthy that the most robust tinnitus-related abnormalities are not in the auditory system, contradicting collective findings of task-activation literature in tinnitus.
Sum-Frequency Spectroscopy of Surfactants Adsorbed at a Flat Hydrophobic Surface (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSum-Frequency Spectroscopy of Surfactants Adsorbed at a Flat Hydrophobic SurfaceRobert N. Ward, David C. Duffy, Paul B. Davies, and Colin D. BainCite this: J. Phys. Chem. 1994, 98, 34, 8536–8542Publication Date (Print):August 1, 1994Publication History Published online1 May 2002Published inissue 1 August 1994https://pubs.acs.org/doi/10.1021/j100085a037https://doi.org/10.1021/j100085a037research-articleACS PublicationsRequest reuse permissionsArticle Views639Altmetric-Citations120LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Protease-Resistant Glucose-Dependent Insulinotropic Polypeptide Agonists Facilitate Hippocampal LTP and Reverse the Impairment of LTP Induced by Beta-Amyloid (2008)

Type 2 diabetes has been identified as a risk factor for Alzheimer's disease (AD). Insulin signaling is often impaired in AD, contributing to the neurodegeneration observed in AD patients. One potential strategy to overcome this impairment is to normalize insulin signaling in the brain. In the present study, we have examined the effects of an enzyme-resistant analogue of glucose-dependent insulinotropic polypeptide (GIP), N-AcGIP, on synaptic plasticity. N-AcGIP is a stable, long-acting peptide hormone that regulates glucose homeostasis and insulin release. We tested the effects of native GIP and the agonist N-AcGIP on synaptic plasticity [long-term potentiation (LTP)] in the hippocampus [15 nmol, administered intracerebroventricularly (icv)] and report for the first time that both peptides have enhancing effects on LTP. In contrast, the antagonist of GIP, Pro(3)GIP (15 nmol icv), reduced LTP. Injection of beta-amyloid(25-35) (100 nmol), a peptide that aggregates in brains of AD patients, also impaired LTP. The injection of N-AcGIP (15 nmol icv) 30 min prior to injection of amyloid(25-35) (100 nmol icv) fully reversed the impairment of LTP induced by beta-amyloid. The results demonstrate for the first time that GIP (particularly enzyme-resistant forms) not only directly modulates neurotransmitter release and LTP formation, but also protects synapses from the detrimental effects of beta-amyloid fragments on LTP formation. The use of enzyme-resistant analogues of GIP show great promise as a potential novel treatment for preventing neurodegenerative processes in AD and other related disorders.