gebhart/patrepeval huggingface dataset:
Antitumor activity of kinetochore-associated protein 2 siRNA against lung cancer patient-derived tumor xenografts (2018)

It has been widely reported that patient-derived tumor xenografts (PDXs) are more similar to tumor tissues than conventional cancer cell lines. Kinetochore-associated protein 2 (KNTC2) is known to be upregulated specifically in tumor tissues of cancer patients and is recognized as a potential target for cancer therapy. Previously, <i>in vivo</i> antitumor activities of KNTC2 short interfering RNA encapsulated into a lipid nanoparticle (KNTC2-LNP) were reported in orthotopic hepatocellular carcinoma mouse models. However, it remains unclear whether KNTC2-LNP exhibits antitumor activities against lung cancer PDXs. In the present study, the antitumor activities of KNTC2-LNP were clarified in a three-dimensional culture system and a subcutaneous tumor model of lung cancer PDX, LC-60, which was resistant to erlotinib. Growth inhibitory activities of KNTC2-LNP were associated with knockdown activities. Furthermore, KNTC2-LNP also exhibited <i>in vivo</i> antitumor activity against another lung cancer PDX, LC-45, which was sensitive to erlotinib. These results suggest that KNTC2 is a promising target for patients with lung cancer.
Hydraulic Behavior of Mechanically and Chemically Activated Synthetic Merwinite (2014)

The hydraulic behavior of synthetic merwinite was investigated after activation by two different methods, aiming to enhance its hydraulic activity which is weak in water. Mechanical activation, by means of extensive milling in a bead mill, led to amorphization of merwinite and a decrease in its crystallite size. The combined effect of higher specific surface area and of structural disorder resulted in a notable increase of hydraulic reactivity. The hydraulic reactivity was substantially more pronounced with chemical activation compared to mechanical activation. Crystalline and amorphous C‐S‐H and brucite were the main hydration products formed in the hydrated, mechanically activated merwinite, whereas portlandite precipitated additionally in the case of chemical activation. Spectroscopic analyses of FTIR and 29 Si MAS NMR verified the C‐S‐H formation. TEM investigations revealed formation of Mg‐low C‐S‐H gel around the merwinite particles. Both mechanically and chemically activated merwinite systems were capable of developing mechanical strength.
Finite Automata and Their Decision Problems (1959)

Finite automata are considered in this paper as instruments for classifying finite tapes. Each one-tape automaton defines a set of tapes, a two-tape automaton defines a set of pairs of tapes, et cetera. The structure of the defined sets is studied. Various generalizations of the notion of an automaton are introduced and their relation to the classical automata is determined. Some decision problems concerning automata are shown to be solvable by effective algorithms; others turn out to be unsolvable by algorithms.
Synthesis of Different Mesoporous SiO2 Structures by Using PNIPAM‐co‐PS Particles as Templates (2014)

Summary Different mesoporous SiO 2 structures were synthesized by a novel process in which poly(N‐isopropyl acrylamide)‐ co ‐polystyrene (PNIPAM‐ co ‐PS) copolymer particles with 10 and 35 wt% styrene, respectively, acted as templates. The copolymer particles were prepared by direct miniemulsion polymerization and subsequently assembled by sedimentation‐aggregation with the silica precursor tetraethyl orthosilicate (TEOS). After a sol‐gel process the polymeric cores were removed by calcination at 650 °C. The influence of temperature of the sol‐gel process on the morphology of the mesoporous silica was investigated. Choosing the temperature below or above the lower critical solution temperature (LCST) of the copolymer allows fine‐tuning of the pore size and pore distribution.
Statistical Integrated Circuit Design (2009)

IC manufacturers have become increasingly interested in maximizing yield as a way to maximize profits. As a result, there has recently been renewed interest in computer aids for maximizing yield. While statistical design methods for maximizing circuit yield have been available for more than two decades, it is only recently that such methods have become practical. In this paper, we review some of these methods and illustrate the usefulness of one of these, the boundary integral method, with several examples.
It's alive! continuous feedback in UI programming (2013)

Live programming allows programmers to edit the code of a running program and immediately see the effect of the code changes. This tightening of the traditional edit-compile-run cycle reduces the cognitive gap between program code and execution, improving the learning experience of beginning programmers while boosting the productivity of seasoned ones. Unfortunately, live programming is difficult to realize in practice as imperative languages lack well-defined abstraction boundaries that make live programming responsive or its feedback comprehensible.
Effect of die geometry on residual stress level present after bar drawing (2001)

AbstractAbstractA new drawing die designed to reduce the residual stresses in bar after drawing is presented. The die design consists of two consecutive straight taper portions, and the outlet portion has a very small die angle. The marked beneficial effect of adding the outlet portion was predicted by finite element modelling (FEM), and subsequently verified by measuring the residual stresses in drawn bars. The optimum range of the outlet die angle was determined using FEM. The new design requires a slightly longer die length than the conventional one, but it is short enough to be adopted in current production lines.
Primary stimuli of icosanoid release inhibit arachidonoyl‐CoA synthetase and lysophospholipid acyltransferase (1990)

Icosanoid formation in platelets depends on the concentration of free arachidonate that is mainly liberated from membrane phospholipids by phospholipase A2. The concentration of free arachidonate is also controlled by the activities of the reacylating enzymes arachidonoyl-CoA synthetase and lysophospholipid acyltransferase. In human platelet microsomes we determined the high enzyme activities of 5.9 nmol.min-1.(10(9) platelets)-1 for the arachidonoyl-CoA synthetase and 37 nmol.min-1.(10(9) platelets)-1 for the lysophospholipid acyltransferase. The activities of these reacylating enzymes were strongly reduced by hydrogen peroxide (H2O2) and methyl mercury that are primary stimuli of arachidonate release in intact platelets. H2O2 inhibited the arachidonoyl-CoA synthetase with an IC50 of 3.3 mmol/l without affecting the lysophospholipid acyltransferase. Sulfhydryl group protection by 3-mercapto-1,2-propanediol did not overcome the inhibition but glutathione prevented the inhibition of the arachidonoyl-CoA synthetase by H2O2. This suggests that glutathione by virtue of the glutathione peroxidase reduces H2O2 rather than that it protects free sulfhydryl groups of the arachidonoyl-CoA synthetase. Methyl mercury left the arachidonoyl-CoA synthetase activity unaffected but inhibited the lysophospholipid acyltransferase activity with an IC50 of 3.4 mumol/l. The inhibition is probably evoked by the blockade of sulfhydryl groups of the lysophospholipid acyltransferase because it disappeared when 3-mercapto-1,2-propanediol was added at a concentration higher than that of methyl mercury. Thrombin as a physiological full agonist, Ca2+ less than or equal to 1 mmol/l, the calcium ionophore A23187 and phorbol 12-myristate 13-acetate (TPA) and 1-oleoyl-2-acetylglycerol as model stimuli of protein kinase C neither influenced arachidonoyl-CoA synthetase nor lysophospholipid acyltransferase. It is concluded that the inhibitory effect of H2O2 and methyl mercury on the arachidonate-reacylating enzymes arachidonoyl-CoA synthetase or lysophospholipid acyltransferase, respectively, are responsible for their capacity to stimulate icosanoid release in intact cells. Thrombin and its intracellular messengers Ca2+ and diacylglycerol do not directly affect arachidonoyl-CoA synthetase and lysophospholipid acyltransferase.
A 0.35 ¿m SiGe BiCMOS Technology for Power Amplifier Applications (2007)

In this paper we introduce, a state-of-the-art SiGe BiCMOS power amplifier technology that features two NPNs with 40 GHz / 6.0 V & 27 GHz / 8.5 V (f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> - BV <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ceo</sub> ) respectively, a novel low inductance metal ground through-silicon-via (TSV), integrated on a low-cost 0.35 μm lithography node with 3.3 V / 5.0 V dual-gate CMOS technology and high-quality passives on a 50 Ω.cm substrate.
A single dose of recombinant VSV-∆G-spike vaccine provides protection against SARS-CoV-2 challenge (2020)

The COVID-19 pandemic caused by SARS-CoV-2 imposes an urgent need for rapid development of an efficient and cost-effective vaccine, suitable for mass immunization. Here, we show the development of a replication competent recombinant VSV-∆G-spike vaccine, in which the glycoprotein of VSV is replaced by the spike protein of SARS-CoV-2. In-vitro characterization of this vaccine indicates the expression and presentation of the spike protein on the viral membrane with antigenic similarity to SARS-CoV-2. A golden Syrian hamster in-vivo model for COVID-19 is implemented. We show that a single-dose vaccination results in a rapid and potent induction of SARS-CoV-2 neutralizing antibodies. Importantly, vaccination protects hamsters against SARS-CoV-2 challenge, as demonstrated by the abrogation of body weight loss, and alleviation of the extensive tissue damage and viral loads in lungs and nasal turbinates. Taken together, we suggest the recombinant VSV-∆G-spike as a safe, efficacious and protective vaccine against SARS-CoV-2.
Interference Mitigation Using an Array Feed (2004)

We study in simulation the use of an array feed of electrically small elements for RFI mit-igation. For a 25 meter reflector and seven element array, in the presence of an interferer, the classical max-SNR spatial filtering algorithm rejects the interferer at all interferer power levels and arrival angles. The effective sensitivity of the array feed and reflector system, with the interfering signal considered as part of the system noise, is similar to that of a simple circular waveguide feed. As the interferer moves, sensitivity fluctuates by a few dB due to a quasi-grating lobe effect. 1
The Ω key management service* (1996)

In this paper we introduce Ω, a distributed public key management service for open networks. Ω offers interfaces by which clients can register, retrieve, and revoke public keys, and escrow, use (to decrypt messages), and recover private keys, all of which can be subjected to access control policy. Ω is built using multiple servers in a way that ensures its correct operation despite the malicious corruption of fewer than one-third of its component servers. We describe the design of Ω, the protocols underlying its operation, performance in our present implementation, and an experimental application of the service.
The influence of NIV on the pulse wave velocity in patients with the exacerbation of COPD (2013)

Introduction . Different researches showed that patients with COPD have greater aortic pulse wave velocity (aPWV), especially the risk of myocardial infarction and ischemic stroke is extremely raised after the COPD exacerbation (G. C. Donaldson, J. R. Hurst et al. CHEST. 2010;137(5):1091-1097). NIV is one of the most effective methods of managing COPD exacerbations. Aims and objectives. The aim of the study was to define the influence of NIV on the aPWV in patients with COPD exacerbation. Methods. 33 patients with the exacerbation of COPD type I Anthonisen were examined. In all patients aPWV was determined by SphygmoCor (AtCor). Patients were randomised into two groups. Group I included 16 patients receiving NIV (IPAP=20 cmH2O; EPAP=5 cmH2O). Group II included 17 patients receiving oxygen by Venturi masks. Medications were the same in both groups. For statistical analysis, Mann-Whitney test was applied. Results. Patients of the I group had higher respiratory rate (RR), lower SpO2 and pH on admission. Clinical signs on admission RR (per minute) SpO2 (%) pH I group 29 [28; 30]* 83 [82; 84]* 7,3 [7,25; 7,35]* II group 24 [23; 25] 90 [89; 91,5] 7,37 [7,35; 7,4] * p&lt;0,05 The level of aPWV was comparable in both groups on admission, and it was significantly differ on the 7th day of hospitalization. aPWV level (m/s) 1th day 7th day I group 11,6 [10,1; 12,1]* 8,4 [6,5; 8,6]** II group 12 [9,3; 12,5] 10,95 [8,85; 11,8] * p=0,1; **p=0,005 There were no differences in need for endotracheal intubation, lethality and hospital stay in both groups. Conclusion. Managing the COPD exacerbation with the NIV leads to decrease aortic PWV and, probably, to reduce the cardiovascular risk in this category of patients.
Tandem Measurement of D‐dimer and Myeloperoxidase or C‐reactive Protein to Effectively Screen for Pulmonary Embolism in the Emergency Department (2008)

The tandem measurement of D-dimer and MPO would have significantly decreased negative pulmonary vascular imaging compared with D-dimer alone and should be validated prospectively.
CHEMOKINE EXPRESSION IN NERVE ALLOGRAFTS (2004)

Induction of specific chemokine genes precedes nerve allograft infiltration by immunocompetent cells. MIP-1 alpha, MIP-2, and RANTES may be responsible for recruiting macrophages, granulocytes, and lymphocytes, respectively, to the rejecting allograft. In future studies, blockade of these specific chemokines or their receptors may prove to delay or prevent nerve allograft rejection.
High-Throughput Functional Ex-Vivo Drug Testing and Multi-Omics Profiling in Patients with Acute Myeloid Leukemia (2019)

Acute myeloid leukemia (AML) is the most common leukemia in adults and the prognosis is dismal. The heterogeneity of driver mutations in AML from one patient to another is significant. Although new treatment targets and modalities have recently been introduced, a lack of therapies to cover the entire spectrum of molecularly distinct AML classes remains a challenge. Furthermore, often only a fraction of the patients carrying mutations actually respond to the drugs predicted to target such genomic subtypes in AML. Our question was if outcome can be improved by optimizing existing and emerging therapies? To address this, we applied direct functional drug testing ex vivo in patients with newly diagnosed AML, along with deep molecular profiling to identify new therapeutic and diagnostic opportunities for specific genetic subclasses. To date, 122 patient samples have been included in the study. We have collected AML patient mononuclear cells isolated from fresh bone marrow aspirates from the Karolinska University Hospital Huddinge and Uppsala University Hospital, or applied biobanked samples from the Swedish acute leukemia biobank. The cells from the patient are tested for 72h with up to 525 conventional and investigative oncology drugs in a 5-point concentration range to determine optimal treatment options. The test is based on bulk cell viability and the cells are cultured in bone marrow stroma-conditioned media. The data is compared to healthy bone marrow controls to filter out generally toxic drugs and combinations. Excess patient material is applied for multi-omics analysis, including genome sequencing, deep proteomic profiling, concentrations of soluble factors, bulk/single-cell RNA sequencing and mass cytometry. Our results indicate significant heterogeneity in functional drug responses across individual patients, even among those with the same founder mutations. We could identify potential targeted treatments for most patients based on the exvivo testing. For instance, patients that show resistance to the Bcl-2 inhibitor Venetoclax can be associated with a distinct drug sensitivity response pattern that includes drugs with different mechanisms of actions. Based on the clustering of drug response data in all clinical samples, we could identify groups of patients with similar global drug responses, and drugs with similar patterns of efficacy across all patients. Disclosures Lehmann: Pfizer: Membership on an entity's Board of Directors or advisory committees; Abbive: Membership on an entity's Board of Directors or advisory committees; TEVA: Consultancy, Membership on an entity's Board of Directors or advisory committees. Kallioniemi:Medisapiens: Other: Co-founder and stockholder; Sartar Therapeutics: Other: Co-founder and stockholder; Astra-Zeneca: Other: Joint Grant; Pelago: Other: Joint Grant; Takara: Other: Joint Grant; Abbot: Other: Licensing income.
Polymerization of olefins with the TiCl4/SiO2 catalyst system modified with MgCl2 (1994)

Abstract MgCl 2 /TiCl 4 /SiO 2 catalysts were prepared by treating TiCl 4 /SiO 2 with MgCl 2 · 2THF (THF: tetrahydrofuran) at different Mg/Ti ratios. The catalysts were analysed by X‐ray, electron spin resonance (ESR), atomic absorption spectrometry to determine the crystal structure, oxidation state of titanium and also contents of Ti, Al and Mg. Homo‐ and copolymerizations of ethylene and propene were conducted with them using Al(i‐C 4 H 9 ) 3 as a cocatalyst. The results of polymerization were correlated with the analytical data of the catalyst.
Recent CD accuracy improvements for HL-7000M (2004)

A new electron beam mask writer, HL-7000M, has been developed for mass production of 90 nm node photomask and, research and development of 65 nm node mask. A series of adjustments to improve CD accuracy provides us a novel systematic solution for VSB system optimization. By applying a novel constant-gain method for linearity adjustment, linearity range, for designed size ranging from 0.3 um to 1.0 um, has been improved to < 3 nm for line and space pattern, the maximum XY discrepancy is 2 nm. Both experimental and theoretical studies for shot-divided patterns, which are often generated in OPC pattern conversion, have been applied. By modification of the shift term in beam size correction, exposure results for such shot-divided patterns, for divided pattern size varied from 500 nm to 1 nm, are improved to be less than 5 nm in range.
Reference Tone Aided Transmission for Massive MIMO: Analog Beamforming without CSI (2018)

This work proposes a novel transmission scheme, namely Reference Tone Aided Transmission (RTAT), that can enable communication in massive MIMO systems with a single analog-to-digital converter at the receiver. Unlike conventional low complexity MIMO transceivers, it can perform receive beamforming without explicit channel estimation or use of phase shifters, thereby leading to a significant reduction in channel estimation overhead and simpler initial access. In RTAT, a sinusoidal reference tone is transmitted along with the data signals. At each receive antenna, the reference tone is recovered, and multiplied by the received signals, to obtain a base-band signal whose inter-antenna phase shift has been compensated. The resulting low-pass signals from all the antennas are then added, emulating maximal ratio combining at the receiver with imperfect channel knowledge. In this work, a receiver architecture for RTAT is proposed, its performance is analyzed and is compared with that of fully digital beamforming. The capacity maximizing power allocation problem is also considered, and one possible initial access protocol for RTAT is suggested. Simulation results show that, in comparison to hybrid beamforming, RTAT suffers only a small loss in signal-to-noise ratio, while providing a significant reduction in the channel estimation overhead.
Filter Paper as a Blood Sample Collection Device for Newborn Screening (2016)

Newborn screening (NBS)3 has been acclaimed by the Centers for Disease Control and Prevention as one of the most successful public health programs of the 21st century (1). In 2013, we celebrated the 50th anniversary of NBS, and these 50 years were marked by many successes. An estimated 200 million newborns in the US have been screened during that period for at least 1 disorder, phenylketonuria. Today's screening effort detects >10 000 newborns with certain heritable disorders from the 4 million screened annually. Most of these disorders cause severe, nonreversible harmful effects if not identified and treated before the onset of symptoms (2). NBS programs have evolved as new technologies have been introduced from covering 1 disorder to presently 33 recommended disorders in the US (3, 4).

All NBS programs in the US collect blood samples on US Food and Drug Administration–cleared filter paper collection devices (5). Only 2 commercial sources are presently approved for use in device production and dried blood spot (DBS) collection. The filter papers, Whatman Grade 903 and Ahlstrom Grade 226, are made from high-purity cotton linters and manufactured to yield accurate and reproducible blood samples according to the Clinical and Laboratory Standards Institute's specifications (NBS01-A6) (5). Under controlled conditions, the filter paper blood collection device for NBS can achieve the same level of precision and reproducibility expected from clinical methods that typically use blood collected in vacuum tubes or capillary pipettes (6). Unlike these liquid collection devices, filter paper exhibits different levels of imprecision, but these can be characterized and then harmonized to minimize the variation it contributes to measurements (6).

Simplicity of collection, transport, and storage makes DBS samples an economical preference for many clinical applications. However, poor-quality filter paper and improperly collected DBS may significantly alter the performance of …
Joint Wireless Information and Energy Transfer in a Two-User MIMO Interference Channel (2013)

This paper investigates joint wireless information and energy transfer in a two-user MIMO interference channel, in which each receiver either decodes the incoming information data (information decoding, ID) or harvests the RF energy (energy harvesting, EH) to operate with a potentially perpetual energy supply. In the two-user interference channel, we have four different scenarios according to the receiver mode -- ($ID_1$, $ID_2$), ($EH_1$, $EH_2$), ($EH_1$, $ID_2$), and ($ID_1$, $EH_2$). While the maximum information bit rate is unknown and finding the optimal transmission strategy is still open for ($ID_1$, $ID_2$), we have derived the optimal transmission strategy achieving the maximum harvested energy for ($EH_1$, $EH_2$). For ($EH_1$, $ID_2$), and ($ID_1$, $EH_2$), we find a necessary condition of the optimal transmission strategy and, accordingly, identify the achievable rate-energy (R-E) tradeoff region for two transmission strategies that satisfy the necessary condition - maximum energy beamforming (MEB) and minimum leakage beamforming (MLB). Furthermore, a new transmission strategy satisfying the necessary condition - signal-to-leakage-and-energy ratio (SLER) maximization beamforming - is proposed and shown to exhibit a better R-E region than the MEB and the MLB strategies. Finally, we propose a mode scheduling method to switch between ($EH_1$, $ID_2$) and ($ID_1$, $EH_2$) based on the SLER.