gebhart/patrepeval huggingface dataset:
Spectral-domain optical coherence tomography at 1.3 μm wavelength with 19-kHz A-line acquisition rate (2004)

We demonstrate spectral-domain optical coherence tomography (SD-OCT) with A-line acquisition rate of 19 kHz with sensitivity of &gt;105 dB over 2-mm depth range, using InGaAs line- scan camera and broadband source at 1.31 μm wavelength.
SHOULDER ARTHROPLASTY FOR ARTHRITIS AFTER INSTABILITY SURGERY (2002)

The data from the present study suggest that shoulder arthroplasty for the treatment of osteoarthritis of the glenohumeral joint following instability surgery in this relatively young group of patients provides pain relief and improved motion but is associated with high rates of revision surgery and unsatisfactory results due to component failure, instability, and pain due to glenoid arthritis.
Separation-free dual solid phase enzyme immunoassay for macromolecules (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSeparation-free dual solid phase enzyme immunoassay for macromoleculesKeith J. Schray and Raymond S. NiedbalaCite this: Anal. Chem. 1988, 60, 4, 353–356Publication Date (Print):February 15, 1988Publication History Published online1 May 2002Published inissue 15 February 1988https://pubs.acs.org/doi/10.1021/ac00155a017https://doi.org/10.1021/ac00155a017research-articleACS PublicationsRequest reuse permissionsArticle Views30Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data (2011)

The results are consistent with the polygenic model of inheritance. The cumulative genetic risk established using currently available genome-wide association data provides important insights into disease heterogeneity and completeness of current knowledge in MS genetics.
Publisher’s Note: “Guided-mode-resonance-coupled plasmonic-active SiO2 nanotubes for surface enhanced Raman spectroscopy” [Appl. Phys. Lett. 100, 191114 (2012)] (2012)

First Page
Ultrashort, high-power pulse generation from a master oscillator power amplifier based on external cavity mode locking of a quantum-dot two-section diode laser (2005)

We investigate an external cavity curved two-section mode-locked diode laser system based on quantum-dot (QD) gain media near 1.3μm. Pulses are generated from the external laser cavity at a 5-GHz repetition rate and amplified using a multilayer quantum-dot semiconductor optical amplifier. The pulses are compressed with a dual-grating dispersion compensator. The shortest, near transform-limited pulses are obtained when the mode-locked pulses are positive (up) chirped. The compressed pulses are 1.2ps in duration, with a pulse energy of 1.46pJ, implying a peak power of 1.22W.
Plasmid DNA delivery into MDA-MB-453 cells mediated by recombinant Her-NLS fusion protein (2010)

A major rate-limiting step in nonviral gene delivery is the entry of nucleic acids across various membrane barriers and eventually into the nucleus where it must be transcribed. Cell-penetrating peptides and proteins are employed to generate formulations that overcome these challenges to facilitate DNA delivery into cells efficiently. However, these are limited by their inability to deliver nucleic acids selectively due to lack of specificity because they deliver to both cancer and normal cells. In this study, through modular design, we generated a recombinant fusion protein designated as Her-nuclear localization sequence (Her-NLS), where heregulin-α (Her), a targeting moiety, was cloned in frame with cationic NLS peptide to obtain a cell-specific targeting biomolecule for nucleic acid delivery. The heregulin-α(1) isoform possesses the epidermal growth factor-like domain and binds to HER2/3 heterodimers which are overexpressed in certain breast cancers. Purified recombinant Her-NLS fusion protein binds plasmid DNA and specifically transfects MDA-MB-453 cells overexpressing the epidermal growth factor receptors HER2/3 in vitro. The approach described would also permit replacement of heregulin ligand with other targeting moieties that would be suited to cell-specific nucleic acid delivery mediated via receptor-ligand interactions.
Optical X-haul options for 5G fixed wireless access: Which one to choose? (2018)

5G is anticipated to be a significant leap in the evolution of mobile communication. Being designed to facilitate 10 to 100 times more capacity than 4G, 5G is considered to be the most cost-efficient solution to provide Fixed Wireless Access (FWA) to households on a large scale where providing last mile access using wired solution might not be economically viable. With a range of promises to deliver user experience improvements, facilitating cost-efficient data transportation between FWA users and network core still remains an unsolved issue, given the enormous volume of data that will be traversing the superior 5G network. This work addresses this compelling problem by formulating a joint-optimization framework to plan and analyze the optimal deployment of diverse optical x-haul strategies that can be used in 5G-based FWA networks. The work provides a cornerstone for deployment strategies that will be imperative to realize future-proof FWA network.
Time reversal of acoustic waves in the nonlinear regime: basic physics and application to ultrasound contrast imaging (2008)

Time reversal invariance of acoustic waves propagation remains valid even in the nonlinear regime in nondissipative media. This very interesting property that was extensively used in linear acoustics can also find potential applications in the nonlinear regime. Harmonic imaging coupled to the use of contrast agents is a topic of wide interest in ultrasonic medical imaging. Images are built at twice the excitation frequency that corresponds to the resonance frequency of the bubbles embedded in the medium. Consequently, the contrast becomes important between areas of low and high concentration of bubbles. However, at a high mechanical index, the harmonic components of backscattered echoes depends on the intrinsic nonlinear properties of tissues as well as the bubble's resonance. The focused beam is generating harmonics during its nonlinear propagation. It results in a degradation of the harmonic image contrast. Time reversal is an elegant way to find the emission codes allowing us to cancel the harmonic components due to nonlinear propagation of the ultrasonic beam. In the absence of bubbles, if the backscattered echoes are time-reversed and reemitted by the array, the harmonic components of the resulting wavefront are transferred back to the fundamental frequency during propagation. Experiments conducted with 1D-linear arrays illustrate these cancellation techniques.
Determination of Liquidus Temperature in Sn–Ti–Zr Alloys by Viscosity, Electrical Conductivity and XRD Measurements (2009)

Abstract The Sn – Ti – Zr system is an important subsystem for Cu based active brazing filler metals. Experimental results on this system, however, are rather scarce. The diagram is rather uncertain regarding most of the liquidus, especially on the Sn rich side. In this work, the atomic structure and temperature dependence of structure-sensitive physical properties (dynamic viscosity and electrical conductivity) of liquid Sn – Ti – Zr alloys in the Sn-rich corner were investigated in a wide temperature range with special attention to the melting – solidification region. The results allowed the liquidus line position to be specified.
Association Between Elevated Mean Arterial Blood Pressure and Neurologic Outcome After Resuscitation From Cardiac Arrest: Results From a Multicenter Prospective Cohort Study* (2018)

Elevated blood pressure during the initial 6 hours after resuscitation from cardiac arrest was independently associated with good neurologic function at hospital discharge. Further investigation is warranted to determine if targeting an elevated mean arterial blood pressure would improve neurologic outcome after cardiac arrest.
The Role of T-Lymphocytes in Hypercholesterolemia-Induced Leukocyte-Endothelial Interactions (2002)

Objective: Hypercholesterolemia promotes the adhesion of leukocytes to vascular endothelium in large and microscopic blood vessels. Lymphocytes that can modulate endothelial cell adhesion molecule expression have been implicated in the altered structure and function of large arterial vessels associated with chronic hypercholesterolemia. This study assesses the contribution of CD4+ and CD8+ T-cells to acute inflammatory responses observed in the microcirculation of hypercholesterolemic mice. Methods: Intravital microscopy was used to quantify baseline leukocyte-endothelial cell interactions in cremasteric postcapillary venules of wild-type (WT) and severe combined immunodeficient (SCID) mice placed on a normal (ND) or high-cholesterol (HC) diet for 2 weeks. A group of SCID-HC mice received splenocytes from WT-HC mice (WT→SCID). Separate WT-HC groups were depleted of neutrophils or CD4+ and/or CD8+ T-cells. Results: WT-HC mice, compared with WT-ND, exhibited exaggerated leukocyte adherence and emigration. These leukocytes were predominantly granulocytes. These responses were absent in neutropenic WT-HC mice. SCID-HC mice also showed significantly less leukocyte adherence and emigration than WT-HC mice. Elevated leukocyte adherence and emigration were restored in WT→SCID mice, despite a continued absence of circulating blood lymphocytes. Selective depletion of either CD4+ or CD8+ cell populations attenuated HC-induced leukocyte adhesion but not emigration. However, simultaneous depletion of both CD4+ and CD8+ cells attenuated both leukocyte adhesion and emigration to ND levels. Discussion: These findings indicate that both CD4+ and CD8+ T-cells contribute to granulocyte adhesion and emigration elicited in postcapillary venules by hypercholesterolemia.
A luminous 3 kiloparsec infrared disk in NGC 1068 (1984)

A 10 micron map of the Seyfert galaxy NGC 1068 and airborne measurements of its angular extent in the far-infrared are presented. It is shown that the infrared emission originates primarily from two physically distinct regions; approximately half of the total infrared luminosity of 3 x 10 to the 11th solar luminosities is associated with the Seyfert nucleus and half with a 3 kpc (35 arc sec) diameter disk surrounding it. It is argued that the disk component of infrared emission originates from an extended but heavily obscured burst of star formation which resembles those seen in some non-Seyfert galaxies. This high-luminosity disk is distinguished more by its large size than by its high surface brightness. On the basis of current evidence it cannot be concluded that the high disk luminosity in NGC 1068 is causally related to its Seyfert activity.
Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF (2021)

Tumour necrosis factor (TNF) is a trimeric protein which signals through two membrane receptors, TNFR1 and TNFR2. Previously, we identified small molecules that inhibit human TNF by stabilising a distorted trimer and reduce the number of receptors bound to TNF from three to two. Here we present a biochemical and structural characterisation of the small molecule-stabilised TNF-TNFR1 complex, providing insights into how a distorted TNF trimer can alter signalling function. We demonstrate that the inhibitors reduce the binding affinity of TNF to the third TNFR1 molecule. In support of this, we show by X-ray crystallography that the inhibitor-bound, distorted, TNF trimer forms a complex with a dimer of TNFR1 molecules. This observation, along with data from a solution-based network assembly assay, leads us to suggest a model for TNF signalling based on TNF-TNFR1 clusters, which are disrupted by small molecule inhibitors.
Retinoic acid inhibits IL-6-dependent but not constitutive STAT3 activation in Epstein-Barr virus-immortalized B lymphocytes (2004)

IL-6-mediated B-cell growth promotion is involved in the pathogenesis of EBV+ lymphoproliferative disorders of immunosuppressed patients. Since retinoic acid (RA) inhibits the proliferation of EBV-immortalized lymphoblastoid B-cell lines (LCLs), we have investigated the effects of RA on IL-6 signaling in these cells. RA down-regulated IL-6-receptor components with IL-6 agonist activity (membrane and soluble gp80) and increased the levels of soluble gp130, an IL-6 antagonist. These changes, however, were not related to the enhanced production of endogenous IL-6 induced by RA in LCLs. RA-induced modulation of IL-6 receptor components did not abolish IL-6-mediated phosphorylation of gp130, whereas JAK1 and STAT3 phosphorylation and activation induced by IL-6 were markedly inhibited. Overall, the effects of RA resulted in the induction of a complete resistance of LCLs to IL-6-mediated growth promotion. Conversely, RA did not inhibit the constitutive activation of JAK1, TYK2, STAT3 and ERK1/2, ruling out that the JAK/STAT and MAPK pathways may mediate the antiproliferative activity of RA. The finding that RA severely impairs IL-6-dependent signalings in LCLs and inhibits their growth despite the presence of constitutively active JAK/STAT and MAPK cascades provide additional support for a role of RA in the prevention and treatment of EBV-related lymphoproliferative disorders of immunosuppressed patients.
The IRF4 gene regulatory module functions as a read-write integrator to dynamically control T helper cell fate (2018)

Abstract Transcriptional regulation during CD4+ T cell fate decisions enables their differentiation into distinct states, guiding immune responses towards antibody production via Tfh cells or inflammation by Teff cells. Tfh–Teff fate commitment is regulated by mutual antagonism between the transcription factors Bcl6 and Blimp-1. Here we examined how T cell receptor (TCR) signals establish and arbitrate Bcl6–Blimp-1 counter-antagonism. We found that the TCR-signal induced transcription factor IRF4 is essential for the differentiation of Bcl6-expressing Tfh and Blimp-1-expressing Teff cells. Increased TCR signaling raised IRF4 amounts and promoted Teff fates at the expense of Tfh ones. Importantly, orthogonal induction of IRF4 expression redirected Tfh fate trajectories towards those of Teff and this occurred independently of IL-2 signals. Mechanistically, we linked greater IRF4 abundance with its recruitment towards low affinity binding sites within Teff cis-regulatory elements, including those of Prdm1. We propose that the Irf4 locus functions as the "reader" of TCR signal strength, in turn, concentration-dependent activity of IRF4 "writes" T helper fate choice.
Dynamic analysis and experimental evaluation of delta modulators for field-oriented AC machine current regulators (1990)

Implementation of field-oriented control requires regulation of the temporal orientation of flux and current vectors in AC machines. The orientation is generally achieved via instantaneous control of stator current relative to either the measured flux or the indirectly estimated flux terms. In either case, the instantaneous control of current is critical. A novel approach for current regulation is presented, based on the use of a nonlinear discrete-time delta modulator which offers the potential for reduced parameter sensitivity and more accurate command tracking than either classical or state-space linear system controllers. A power electronic topology, the resonant DC link is ideally suited to implement this controller. Experimental data on a field-oriented induction machine controller using a resonant DC link inverter topology demonstrate the command tracking performance of this induction-machine current regulator.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
THE SUSTAINABLE DEVELOPMENT STRATEGY OF AGRICULTURE IN SHANDONG PROVINCE (2000)

Shandong is one of the strongest agricultural provinces in china. The agricultural development is the key problem in Shandongs economy. This paper has demonstrated some defect factors existed in the agricultural development of Shandong province and suggests some solutions for the sustainable development of agriculture in Shandong.
Supplementary Figure 1 from Loss of Tuberous Sclerosis Complex 2 (TSC2) Is Frequent in Hepatocellular Carcinoma and Predicts Response to mTORC1 Inhibitor Everolimus (2023)

&lt;p&gt;TSC2 loss in HCC cell lines leads to mTOR activation. (A) Reverse Phase Protein Array (RPPA) analysis of nine HCC cell lines for TSC2 protein levels and phosphorylation levels of S6K1, 4E-BP1, S6 and AKT. (B) Immunoblot of TSC2 wild-type HuH-7 cells treated with inhibitors of PI3K, AKT or MEK. (C) p-S6K1(T389) immunoblot of TSC2-null HCC cell lines treated with varying concentrations of everolimus.&lt;/p&gt;
Effect of Secondary Ions on the Electron Beam Optics in the Recycler Electron Cooler (2010)

AAntiprotons in Fermilab¿s Recycler ring are cooled by a 4.3 MeV, 0.1 ¿ 0.5 A DC electron beam (as well as by a stochastic cooling system). The unique combination of the relativistic energy (γ = 9.49), an Ampere - range DC beam, and a relatively weak focusing makes the cooling efficiency particularly sensitive to ion neutralization. A capability to clear ions was recently implemented by way of interrupting the electron beam for 1-30 µs with a repetition rate of up to 40 Hz. The cooling properties of the electron beam were analyzed with drag rate measurements and showed that accumulated ions significantly affect the beam optics. For a beam current of 0.3 A, the longitudinal cooling rate was increased by factor of ~2 when ions were removed.
Surface Modification of ZnO Using Triethoxysilane-Based Molecules (2008)

Zinc oxide (ZnO) is an important material for hybrid inorganic-organic devices in which the characteristics of the interface can dominate both the structural and electronic properties of the system. These characteristics can be modified through chemical functionalization of the ZnO surface. One of the possible strategies involves covalent bonding of the modifier using silane chemistry. Whereas a significant body of work has been published regarding silane attachments to glass and SiO2, there is less information about the efficacy of this method for controlling the surface of metal oxides. Here we report our investigation of molecular layers attached to polycrystalline ZnO through silane bonding, controlled by an amine catalyst. The catalyst enables us to use triethoxysilane precursors and thereby avoid undesirable multilayer formation. The polycrystalline surface is a practical material, grown by sol-gel processing, that is under active exploration for device applications. Our study included terminations with alkyl and phenyl groups. We used water contact angles, infrared spectroscopy, and X-ray photoemission spectroscopy to evaluate the modified surfaces. Alkyltriethoxysilane functionalization of ZnO produced molecular layers with submonolayer coverage and evidence of disorder. Nevertheless, a very stable hydrophobic surface with contact angles approaching 106 degrees resulted. Phenyltriethoxysilane was found to deposit in a similar manner. The resulting surface, however, exhibited significantly different wetting as a result of the nature of the end group. Molecular layers of this type, with a variety of surface terminations that use the same molecular attachment scheme, should enable interface engineering that optimizes the chemical selectivity of ZnO biosensors or the charge-transfer properties of ZnO-polymer interfaces found in oxide-organic electronics.
Regulation of Nucleocytoplasmic Shuttling of Bruton's Tyrosine Kinase (Btk) through a Novel SH3-Dependent Interaction with Ankyrin Repeat Domain 54 (ANKRD54) (2012)

Bruton's tyrosine kinase (Btk), belonging to the Tec family of tyrosine kinases (TFKs), is essential for B-lymphocyte development. Abrogation of Btk signaling causes human X-linked agammaglobulinemia (XLA) and murine X-linked immunodeficiency (Xid). We employed affinity purification of Flag-tagged Btk, combined with tandem mass spectrometry, to capture and identify novel interacting proteins. We here characterize the interaction with ankryin repeat domain 54 protein (ANKRD54), also known as Lyn-interacting ankyrin repeat protein (Liar). While Btk is a nucleocytoplasmic protein, the Liar pool was found to shuttle at a higher rate than Btk. Importantly, our results suggest that Liar mediates nuclear export of both Btk and another TFK, Txk/Rlk. Liar-mediated Btk shuttling was enriched for activation loop, nonphosphorylated Btk and entirely dependent on Btk's SH3 domain. Liar also showed reduced binding to an aspartic acid phosphomimetic SH3 mutant. Three other investigated nucleus-located proteins, Abl, estrogen receptor β (ERβ), and transcription factor T-bet, were all unaffected by Liar. We mapped the interaction site to the C terminus of the Btk SH3 domain. A biotinylated, synthetic Btk peptide, ARDKNGQEGYIPSNYVTEAEDS, was sufficient for this interaction. Liar is the first protein identified that specifically influences the nucleocytoplasmic shuttling of Btk and Txk and belongs to a rare group of known proteins carrying out this activity in a Crm1-dependent manner.
Discovery of a Novel Hepatovirus ( Phopivirus of Seals) Related to Human Hepatitis A Virus (2015)

Hepatitis A virus (HAV) is an important viral hepatitis in humans because of the substantial number of cases each year in regions with low socioeconomic status. The origin of HAV is unknown, and no nonprimate HAV-like viruses have been described. Here, we describe the discovery of an HAV-like virus in seals. This finding suggests that the diversity and evolutionary history of these viruses might be far greater than previously thought and may provide insight into the origin and pathogenicity of HAV.
Toward single breath‐hold whole‐heart coverage coronary MRA using highly accelerated parallel imaging with a 32‐channel MR system (2006)

Coronary MR angiography (CMRA) is generally confined to the acquisition of multiple targeted slabs with coverage dictated by the competing constraints of signal-to-noise ratio (SNR), physiological motion, and scan time. This work addresses these obstacles by demonstrating the technical feasibility of using a 32-channel coil array and receiver system for highly accelerated volumetric breath-hold CMRA. The use of the 32-element array in unaccelerated CMRA studies provided a baseline SNR increase of as much as 40% over conventional cardiac-optimized phased array coils, which resulted in substantially enhanced image quality and improved delineation of the coronary arteries. Modest accelerations were used to reduce breath-hold durations for tailored coverage of the coronary arteries using targeted multi-oblique slabs to as little as 10 s. Finally, high net accelerations were combined with the SNR advantages of a 3D steady-state free precession (SSFP) technique to achieve previously unattainable comprehensive volumetric coverage of the coronary arteries in a single breath-hold. The merits and limitations of this simplified volumetric imaging approach are discussed and its implications for coronary MRA are considered.