gebhart/patrepeval huggingface dataset:
Mitochondrial Dysfunction in Metabolic Syndrome and Asthma (2013)

Though severe or refractory asthma merely affects less than 10% of asthma population, it consumes significant health resources and contributes significant morbidity and mortality. Severe asthma does not fell in the routine definition of asthma and requires alternative treatment strategies. It has been observed that asthma severity increases with higher body mass index. The obese-asthmatics, in general, have the features of metabolic syndrome and are progressively causing a significant burden for both developed and developing countries thanks to the westernization of the world. As most of the features of metabolic syndrome seem to be originated from central obesity, the underlying mechanisms for metabolic syndrome could help us to understand the pathobiology of obese-asthma condition. While mitochondrial dysfunction is the common factor for most of the risk factors of metabolic syndrome, such as central obesity, dyslipidemia, hypertension, insulin resistance, and type 2 diabetes, the involvement of mitochondria in obese-asthma pathogenesis seems to be important as mitochondrial dysfunction has recently been shown to be involved in airway epithelial injury and asthma pathogenesis. This review discusses current understanding of the overlapping features between metabolic syndrome and asthma in relation to mitochondrial structural and functional alterations with an aim to uncover mechanisms for obese-asthma.
A Nanomedicine Transports a Peptide Caspase-3 Inhibitor across the Blood–Brain Barrier and Provides Neuroprotection (2009)

Caspases play an important role as mediators of cell death in acute and chronic neurological disorders. Although peptide inhibitors of caspases provide neuroprotection, they have to be administered intracerebroventricularly because they cannot cross the blood-brain barrier (BBB). Herein, we present a nanocarrier system that can transfer chitosan nanospheres loaded with N-benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethyl ketone (Z-DEVD-FMK), a relatively specific caspase-3 inhibitor, across BBB. Caspase-3 was chosen as a pharmacological target because of its central role in cell death. Polyethylene glycol-coated nanospheres were conjugated to an anti-mouse transferrin receptor monoclonal antibody (TfRMAb) that selectively recognizes the TfR type 1 on the cerebral vasculature. We demonstrate with intravital microscopy that this nanomedicine is rapidly transported across the BBB without being measurably taken up by liver and spleen. Pre- or post-treatment (2 h) with intravenously injected Z-DEVD-FMK-loaded nanospheres dose dependently decreased the infarct volume, neurological deficit, and ischemia-induced caspase-3 activity in mice subjected to 2 h of MCA occlusion and 24 h of reperfusion, suggesting that they released an amount of peptide sufficient to inhibit caspase activity. Similarly, nanospheres inhibited physiological caspase-3 activity during development in the neonatal mouse cerebellum on postnatal day 17 after closure of the BBB. Neither nanospheres functionalized with TfRMAb but not loaded with Z-DEVD-FMK nor nanospheres lacking TfRMAb but loaded with Z-DEVD-FMK had any effect on either paradigm, suggesting that inhibition of caspase activity and subsequent neuroprotection were due to efficient penetration of the peptide into brain. Thus, chitosan nanospheres open new and exciting opportunities for brain delivery of biologically active peptides that are useful for the treatment of CNS disorders.
Compressed sensing reconstruction for magnetic resonance parameter mapping (2010)

Compressed sensing (CS) holds considerable promise to accelerate the data acquisition in magnetic resonance imaging by exploiting signal sparsity. Prior knowledge about the signal can be exploited in some applications to choose an appropriate sparsifying transform. This work presents a CS reconstruction for magnetic resonance (MR) parameter mapping, which applies an overcomplete dictionary, learned from the data model to sparsify the signal. The approach is presented and evaluated in simulations and in in vivo T(1) and T(2) mapping experiments in the brain. Accurate T(1) and T(2) maps are obtained from highly reduced data. This model-based reconstruction could also be applied to other MR parameter mapping applications like diffusion and perfusion imaging.
A 71&#x2013;76GHz low noise amplifier with integrated image reject filter and single balanced down converter mixer (2011)

An RF receiver front end for EBAND communication in the lower band 71-76GHz frequency range was designed and fabricated in IBM 0.12μm SiGe technology. The LNA composed of four amplification stages, exhibits more than 15dB gain and a NF of less than 6dB in the entire frequency band. A steep two chain stop band filter is used to reject image noise with better than 18dB image rejection. The LNA is followed by a single balanced active down converting mixer used to convert the received signal to the 8.5GHz IF frequency. The measured mixer conversion gain is around 4.5dB with a NF of 14dB. The above performance enables a super-heterodyne realization of a complete EBAND receiver with excellent image rejection.
Agente Fenix: sistema de filtragem personalizada de informações (1999)

Atualmente, a Internet disponibiliza uma extensa quantidade de informacoes, para uma vasta gama de usuarios, tornando-se dificil de manipular. Inspirado nesta dificuldade, o presente trabalho propoe o uso de Agentes Inteligentes para a filtragem personalizada de informacoes. A ideia e desenvolver um conjunto de agentes autonomos, fixos e adaptativos, com o objetivo de satisfazer as necessidades de informacao do usuario. Para a representacao das informacoes, sera adotado o modelo vetor espacial [Salton83], e o mecanismo de aprendizagem dos agentes sera o feedback de relevância [Frakes92] .Esse artigo apresenta a descricao do sistema e os resultados de uma primeira etapa, onde foram feitos testes em um ambiente simulado. Em uma proxima etapa, serao conduzidos testes com usuarios reais. O espaco de busca por onde serao recuperadas as informacoes sao documentos existentes nas paginas da WWW. O sistema foi desenvolvido para ambientes mono-usuarios, e o publico-alvo serao professores, alunos e funcionarios de uma Universidade.
Gene expression of <i>HVA1</i> from microarray and qRT-PCR analysis of two mouse-passaged and one <i>Galleria</i>-passaged <i>C</i>. <i>neoformans</i> strains. (2016)

&lt;p&gt;Gene expression of &lt;i&gt;HVA1&lt;/i&gt; from microarray and qRT-PCR analysis of two mouse-passaged and one &lt;i&gt;Galleria&lt;/i&gt;-passaged &lt;i&gt;C&lt;/i&gt;. &lt;i&gt;neoformans&lt;/i&gt; strains.&lt;/p&gt;
Design and Validation of a Gain-Scheduled Controller for the Electronic Throttle Body in Ride-by-Wire Racing Motorcycles (2010)

This paper presents the analysis, design and validation of a gain-scheduled controller for an electronic throttle body (ETB) designed for ride-by-wire applications in racing motorcycles. Specifically, the open-loop dynamics of the system are studied in detail discussing the effects of friction based on appropriate experiments. Further, a linear time invariant nominal model of the system to be controlled is experimentally identified via a frequency-domain black box approach, together with the uncertainty bounds on the model parameters. Based on these results a model-based gain-scheduled proportional-integral-differential (PID) controller for throttle position tracking is proposed. The closed-loop stability of the resulting linear parametrically varying (LPV) system is proved by checking the feasibility of an appropriate linear matrix inequality (LMI) problem, and the state space representation of the closed-loop LPV system is experimentally validated. Finally, the performance of the controlled system is compared to the intrinsic limit of the actuator and tested under realistic use, namely both on a test-bench employing as set-point the throttle position recorded during test-track experiments and on an instrumented motorcycle.
Enhancement of the immunosuppressive effect of cyclosporin A by ciprofloxacin in a rat cardiac allograft transplantation model (1995)

Abstract Ciprofloxacin hyperinduces interleukin-2 production in stimulated human and mouse lymphocytes. In this study, an enhanced and prolonged interleukin-2 response was also detected in polyclonally stimulated rat splenocytes in the presence of ciprofloxacin (5–80 μ/ml) compared to control cells without any antibiotic. Ciprofloxacin was able to counteract the immunosuppressive effect of 10 ng/ml cyclosporin A (CyA) but did not interfere with higher CyA concentrations. In parallel, ciprofloxacin did not influence thymidine uptake in mixed lymphocyte reactions in the presence of CyA. To obtain an in vivo application of these findings, graft survival was studied by performing rat cardiac allograft transplantations in the presence or absence of CyA. Brown Norway rats served as donors and Wistar Furth rats as recipients. Ciprofloxacin was injected intraperitoneally either at a high-dose regimen (240 mg/kg per 24 h) into rats every 8th h starting 1 day before transplantation until day 21 or graft loss, or it was injected at a low and clinically relevant dose regimen (45 mg/kg per 24 h) until day 9. CyA was administered orally (10 mg/kg per 24 h) from day 1 through day 9. Ciprofloxacin given alone at a high-dose regimen resulted in a median graft survival of 14.8 days, which was significantly longer than graft survival in rats without treatment (median 8.0 days). A low-dose regimen of ciprofloxacin alone did not affect graft survival. Ciprofloxacin at a highdose regimen combined with CyA prolonged graft survival to a median of 24.0 days compared to 20.5 days with CyA alone. Ciprofloxacin administered in the drinking water (200 mg/kg per 24 h) until day 9 in addition to CyA did not affect graft survival. However, when the same dose regimen was used in experiments with PVG rats as donors and Wistar/Kyoto as recipients, graft survival was significantly prolonged to a median of 45 days. Ciprofloxacin, given orally without the addition of CyA, did not influence graft survival in either of the two strain combinations. Thus, our data show that ciprofloxacin has no negative impact on heart graft survival rats. It remains to be clarified whether ciprofloxacin influences graft survival in humans.
New Mesotextured Hybrid Materials Made from Assemblies of Dendrimers and Titanium(IV)-Oxo-Organo Clusters (2000)

„Trockene“ Synthesebedingungen werden bei der Herstellung maßgeschneiderter mesostrukturierter Hybridmaterialien, die aus Dendrimeren (siehe Bild) und [Ti16O16(OEt)32]-Clustern bestehen, benötigt. Sie verhindern die Bildung einer kontinuierlichen anorganischen Phase. Die Form der organischen Einheiten erzwingt eine lokale Symmetrie, die eine weit reichende Ordnung in der Textur zur Folge hat. (R=CH2OH, CH2CH=CHCOOH.)
Additions and Corrections - Stereochemistry of the Wittig Reaction. Effect of Nucleophilic Groups in the Phosphonium Ylide (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAdditions and Corrections - Stereochemistry of the Wittig Reaction. Effect of Nucleophilic Groups in the Phosphonium YlideBruce Maryanoff, Allen Reitz, and Barbara Duhl-EmswilerCite this: J. Am. Chem. Soc. 1985, 107, 7, 2199Publication Date (Print):April 1, 1985Publication History Published online29 March 2004Published inissue 1 April 1985https://pubs.acs.org/doi/10.1021/ja00293a604https://doi.org/10.1021/ja00293a604research-articleACS PublicationsRequest reuse permissionsArticle Views89Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Supplementary Figure S4 from A Human Ribonuclease Variant and ERK-Pathway Inhibitors Exhibit Highly Synergistic Toxicity for Cancer Cells (2023)

&lt;p&gt;Supplementary Figure S4. Amino acid sequences near phosphorylated residues of mammalian RIs. Phosphoryl groups on these residues interact favorably with a ptRNase (Fig. 5E).&lt;/p&gt;
ChemInform Abstract: Synthesis of 4,6‐Disubstituted‐7‐β‐D‐ribofuranosyl‐ and Arabinofuranosylpyrazolo(3,4‐d)pyrimidines and Certain Related Ribonucleosides. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
α2,3‐Sialyl and α1,3‐fucosyltransferase‐dependent synthesis of sialyl Lewis x, an essential oligosaccharide present on L‐selectin counterreceptors, in cultured endothelial cells (1994)

Sialyl Lewis x (sLex) oligosaccharides have been shown to be present in counterreceptors for L-selectin. We and others have previously shown that high endothelial cells in lymph nodes and at sites of inflammation express sLex. Here we show that also cultured human umbilical vein endothelial cells (HUVEC) express sLex on their cell surface. This oligosaccharide is formed by sequential action of alpha 2,3-sialyl- (alpha 2,3-ST) and alpha 1,3-fucosyltransferases (alpha 1,3-FT) on N-acetyllactosamine. At least two of the several alpha 2,3-ST and four of the several alpha 1,3-FT are present in HUVEC. In functional assays both alpha 2,3-ST and alpha 1,3-FT activities were observed in HUVEC lysates with exogenous lactosamine and sialyllactosamine acceptors, leading to the generation of the sialyllactosamine and sLex sequences, respectively. TNF stimulation increased the level of mRNA expression of FT VI, and the alpha 1,3-FT activity in HUVEC. Taken together these data show that endothelial cells express sLex and that they possess mRNA as well as enzyme activities of several alpha 2,3-ST and alpha 1,3-FT necessary in the final steps of sLex synthesis. Furthermore, inflammatory cytokines such as TNF can enhance transferase activities relevant in generating putative L-selectin counterreceptors.
A single amino acid substitution confers B-cell clonogenic activity to the HIV-1 matrix protein p17 (2017)

Recent data highlight the presence, in HIV-1-seropositive patients with lymphoma, of p17 variants (vp17s) endowed with B-cell clonogenicity, suggesting a role of vp17s in lymphomagenesis. We investigated the mechanisms responsible for the functional disparity on B cells between a wild-type p17 (refp17) and a vp17 named S75X. Here, we show that a single Arginine (R) to Glycine (G) mutation at position 76 in the refp17 backbone (p17R76G), as in the S75X variant, is per se sufficient to confer a B-cell clonogenic potential to the viral protein and modulate, through activation of the PTEN/PI3K/Akt signaling pathway, different molecules involved in apoptosis inhibition (CASP-9, CASP-7, DFF-45, NPM, YWHAZ, Src, PAX2, MAPK8), cell cycle promotion and cancer progression (CDK1, CDK2, CDK8, CHEK1, CHEK2, GSK-3 beta, NPM, PAK1, PP2C-alpha). Moreover, the only R to G mutation at position 76 was found to strongly impact on protein folding and oligomerization by altering the hydrogen bond network. This generates a conformational shift in the p17 R76G mutant which enables a functional epitope(s), masked in refp17, to elicit B-cell growth-promoting signals after its interaction with a still unknown receptor(s). Our findings offer new opportunities to understand the molecular mechanisms accounting for the B-cell growth-promoting activity of vp17s.
Extended Cantor Arrays with Hole-Free Fourth-Order Difference Co-Arrays (2021)

We present extended Cantor arrays based on fourth- order difference co-arrays (E-FO-Cantor). These arrays result from extending the recently proposed fractal arrays to fourth- order difference co-arrays, and lead to fourth-order difference co-arrays that are hole-free. The set of sensor positions of the E-FO-Cantor is expressed in a simple and recursive form. The proposed Cantor arrays lead to O(N <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">log2</sup> <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> ) ≈ O(N <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3.17</sup> ) degrees of freedom compared to O(N <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ) that can be achieved by existing sparse arrays with the hole-free property. Compared with other sparse arrays with the hole-free property in their fourth-order co-arrays, the proposed Cantor arrays provide a longer uniform linear array with more virtual sensors, leading to better DOA estimation performance.
Factors Defining Sensitive Skin and its Treatment (1998)

Background: Users of cosmetics and skin care products often report adverse reactions ranging from itching and dryness to intense inflammatory responses such as erythema or wheal and rash. Self-assessment is not always an accurate parameter for categorizing skin as sensitive or nonsensitive, although it can be valuable. For this reason, it is important to define sensitive skin by more objective factors. Objective: Studies were undertaken to determine if objective biophysical measurements could detect differences in barrier function between those individuals who identified themselves as having sensitive skin and those self-identified as having normal skin. In addition, the effects of treatment on barrier functions of individuals with sensitive skin were determined. Methods: Three main factors that contribute to cutaneous reactivities were observed for the estimation of skin sensitivity: barrier functions, reactivity to irritants, and neuronal responses manifested as sensory reactions. Barrier functions of the skin was tested by gentle removal of the stratum corneum with simple cellophane tape stripping followed by measurement of transepidermal water loss (TEWL) as a marker of barrier loss. The onset and intensity of skin reaction against an irritant, balsam of Peru, was tested on the same individuals to observe the reactivity of their skin. Using the lactic acid sting test, additional information regarding skin sensitivities was obtained. Results: Sensitive skin individuals exhibiting easy barrier damage possess delicate skin that is also highly reactive to irritants. When these individuals used a regimen of products that contained minimal preservatives and no surfactants for 8 weeks, the skin barrier and reactivity changed such that it was similar to nonsensitive skin. Conclusions: Skin sensitivity is observed because of a combination of factors, including a disrupted barrier and a tendency to hyperreact to topical agents. Treatment with special topical skin care formulations can reduce overall skin sensitivity.
CPI 2 (2013)

Performance isolation is a key challenge in cloud computing. Unfortunately, Linux has few defenses against performance interference in shared resources such as processor caches and memory buses, so applications in a cloud can experience unpredictable performance caused by other programs' behavior.
Real-Time Probabilistic Data Fusion for Large-Scale IoT Applications (2018)

Internet of Things (IoT) data analytics is underpinning numerous applications, however, the task is still challenging predominantly due to heterogeneous IoT data streams, unreliable networks, and ever increasing size of the data. In this context, we propose a two-layer architecture for analyzing IoT data. The first layer provides a generic interface using a service oriented gateway to ingest data from multiple interfaces and IoT systems, store it in a scalable manner and analyze it in real-time to extract high-level events; whereas second layer is responsible for probabilistic fusion of these high-level events. In the second layer, we extend state-of-the-art event processing using Bayesian networks in order to take uncertainty into account while detecting complex events. We implement our proposed solution using open source components optimized for large-scale applications. We demonstrate our solution on real-world use-case in the domain of intelligent transportation system where we analyzed traffic, weather, and social media data streams from Madrid city in order to predict probability of congestion in real-time. The performance of the system is evaluated qualitatively using a web-interface where traffic administrators can provide the feedback about the quality of predictions and quantitatively using F-measure with an accuracy of over 80%.
HIGH MAGNETIC FIELD STUDY OF 2D ELECTRON GAS IN AlP (2007)

We investigate the properties of quasi-two-dimensional electrons in AlP quantum wells by measuring cyclotron resonance, quantum Hall effect, and Shubnikov de Haas oscillations in modulation-doped AlP - GaP type-II quantum wells. We find that in wide AlP wells, the lowest conduction band states are in the X x and X y valleys transverse to the growth direction, that the valley degeneracy of this state is g v =2, and that the cyclotron effective mass [Formula: see text]. These results indicate that the biaxial compressive strain resulting from the lattice mismatch of AlP quantum well with respect to the GaP substrate and barrier layers causes the longitudinal X z valley to be lifted above the transverse X x and X y valleys. Further, the two-fold degeneracy of the X x and X y valleys indicates that the conduction band minimum in AlP is located exactly at the X-point of the Brillouin zone.
Registration and fusion of multimodal vascular images: a phantom study (2003)

The aim of this work was to compare the geometric accuracy of X-ray angiography, MRI, X-ray computed tomography (XCT), and ultrasound imaging (B-mode and IVUS) for measuring the lumen diameters of blood vessels. An image fusion method also was developed to improve these measurements. The images were acquired from a realistic phantom mimicking normal vessels of known internal diameters. After acquisition, the multimodal images were coregistered, by manual alignment of fiducial markers and then by automatic maximization of mutual information. The fusion method was performed by means of a fuzzy logic modeling approach followed by a combination process based on possibilistic logic. The data showed (i) the good geometric accuracy of XCT compared to the other methods for all studied diameters; and (ii) the good results of fused images compared to single modalities alone. For XCT, the error varied from 1.1% to 9.7%, depending on the vessel diameter that ranged from 0.93 to 6.24 mm. MRI-IVUS fusion allowed variability of measurements to be reduced up to 78%. To conclude, this work underlined both the usefulness of the vascular phantom as a validation tool and the utility of image fusion in the vascular context. Future work will consist of studying pathological vessel shapes, image artifacts and partial volume effect correction.
Aberration functions for microlithographic lens (2006)

We proposed a series of orthogonal aberration functions, which is suitable for a microlithographic projection lens. In this paper, general explanation and numbering of the orthogonal aberration functions are reviewed.