gebhart/patrepeval huggingface dataset:
High Performance Composites Research at NASA-Langley (1988)

&lt;div class="htmlview paragraph"&gt;Barriers to the more extensive use of advanced composites in heavily loaded structure on commercial transports are discussed from a materials viewpoint. NASA-Langley matrix development activities designed to overcome these barriers are presented. These include the synthesis of processable, tough, durable matrices, the development of resin property/composite property relationships which help guide the synthesis program, and the exploitation of new processing technology to effectively combine reinforcement filament with polymer matrices. Examples of five classes of polymers being investigated as matrix resins at NASA-Langley will be presented, including amorphous and semi-crystalline thermoplastics, lightly crosslinked thermoplastics, semi-interpenetrating networks and toughened thermosets. Relationships between neat resin modulus, resin fracture energy, interlaminar fracture energy, composite compression strength, and post-impact compression strength will be shown. Powder and slurry processing techniques will be discussed.&lt;/div&gt;
Influence of substrate dopant concentration on electrical properties and residual defects in pn junction formed by low-temperature post-implantation annealing (2000)

Dependence of the leakage currents in BF2+ implanted junctions on the dopant concentration of the n-type substrate was investigated. It was clarified that the leakage currents of low-temperature-annealed junctions increase as the substrate dopant concentration increases, while high-temperature-annealed junctions have the opposite dependence. We demonstrate that low-leakage currents can be achieved in low-temperature-annealed junctions by using lightly doped silicon substrate. It was confirmed that the higher leakage currents in low-temperature-annealed junctions originate from the implantation-induced defects existing deeply in the substrate. Considering the results of both BF2+ implanted p+n junction and As+ implanted n+p junction, we discuss an implantation-induced defect generation mechanism.
New Class of Antitrypanosomal Agents Based on Imidazopyridines (2017)

The present work describes the synthesis of 22 new imidazopyridine analogues arising from medicinal chemistry optimization at different sites on the molecule. Seven and 12 compounds exhibited an in vitro EC<sub>50</sub> ≤ 1 μM against <i>Trypanosoma cruzi</i> (<i>T. cruzi</i>) and <i>Trypanosoma brucei</i> (<i>T. brucei</i>) parasites, respectively. Based on promising results of <i>in vitro</i> activity (EC<sub>50</sub> < 100 nM), cytotoxicity, metabolic stability, protein binding, and pharmacokinetics (PK) properties, compound <b>20</b> was selected as a candidate for <i>in vivo</i> efficacy studies. This compound was screened in an acute mouse model against <i>T.cruzi</i> (<i>Tulahuen</i> strain). After established infection, mice were dosed twice a day for 5 days, and then monitored for 6 weeks using an <i>in vivo</i> imaging system (IVIS). Compound <b>20</b> demonstrated parasite inhibition comparable to the benznidazole treatment group. Compound <b>20</b> represents a potential lead for the development of drugs to treat trypanosomiasis.
Traffic Engineering Extensions to OSPF for Generalized MPLS (GMPLS) Control of Evolving G.709 OTN Networks (2011)

This document describes OSPF routing protocol extensions to support
the evolutive Optical Transport Networks (OTN) under the control of
Generalized MPLS (GMPLS).
CAMP: A framework for Cooperation Among Mobile Prosumers (2009)

We propose a novel framework for cooperation among mobile prosumers (CAMP) that aims at establishing semantic relations between multimedia content acquired by mobile users, focussing especially on audio-visual media. We discuss the basic properties of such a system and describe a number of possible applications. We also address technical requirements and possible solutions, and show a preliminary implementation of a cooperative video sharing platform.
Discovery of M3 Antagonist-PDE4 Inhibitor Dual Pharmacology Molecules for the Treatment of Chronic Obstructive Pulmonary Disease (2021)

In this paper, we report the discovery of dual M3 antagonist-PDE4 inhibitor (MAPI) compounds for the inhaled treatment of pulmonary diseases. The identification of dual compounds was enabled by the intuition that the fusion of a PDE4 scaffold derived from our CHF-6001 series with a muscarinic scaffold through a common linking ring could generate compounds active versus both the transmembrane M3 receptor and the intracellular PDE4 enzyme. Two chemical series characterized by two different muscarinic scaffolds were investigated. SAR optimization was aimed at obtaining M3 nanomolar affinity coupled with nanomolar PDE4 inhibition, which translated into anti-bronchospastic efficacy ex vivo (inhibition of rat trachea contraction) and into anti-inflammatory efficacy in vitro (inhibition of TNFα release). Among the best compounds, compound 92a achieved the goal of demonstrating in vivo efficacy and duration of action in both the bronchoconstriction and inflammation assays in rat after intratracheal administration.
Mesoporous cross-linked polymer copolymerized with chiral BINAP ligand coordinated to a ruthenium species as an efficient heterogeneous catalyst for asymmetric hydrogenation (2012)

We report here a successful preparation of a heterogeneous chiral catalyst from copolymerization of mesoporous cross-linked polymer with chiral BINAP ligands, followed by coordination of the BINAP with a ruthenium species, which exhibits high activity, excellent enantioselectivity, and extraordinary recyclability in asymmetric hydrogenation.
Structure and mechanism of a bacterial host-protein citrullinating virulence factor, Porphyromonas gingivalis peptidylarginine deiminase (2015)

Citrullination is a post-translational modification of higher organisms that deiminates arginines in proteins and peptides. It occurs in physiological processes but also pathologies such as multiple sclerosis, fibrosis, Alzheimer's disease and rheumatoid arthritis (RA). The reaction is catalyzed by peptidylarginine deiminases (PADs), which are found in vertebrates but not in lower organisms. RA has been epidemiologically associated with periodontal disease, whose main infective agent is Porphyromonas gingivalis. Uniquely among microbes, P. gingivalis secretes a PAD, termed PPAD (Porphyromonas peptidylarginine deiminase), which is genetically unrelated to eukaryotic PADs. Here, we studied function of PPAD and its substrate-free, substrate-complex, and substrate-mimic-complex structures. It comprises a flat cylindrical catalytic domain with five-fold α/β-propeller architecture and a C-terminal immunoglobulin-like domain. The PPAD active site is a funnel located on one of the cylinder bases. It accommodates arginines from peptide substrates after major rearrangement of a "Michaelis loop" that closes the cleft. The guanidinium and carboxylate groups of substrates are tightly bound, which explains activity of PPAD against arginines at C-termini but not within peptides. Catalysis is based on a cysteine-histidine-asparagine triad, which is shared with human PAD1-PAD4 and other guanidino-group modifying enzymes. We provide a working mechanism hypothesis based on 18 structure-derived point mutants.
Three-Dimensional Electromagnetic Scattering Analysis Using Constrained Interpolation Profile Method (2010)

A characteristic-based constrained interpolation profile (CIP) method for solving three-dimensional, time-dependent Maxwell's equations is successfully developed. It is utilized to solve one-dimensional wave equations in the formulation of the Maxwell's equations. Calculation procedure of the CIP method for three-dimensional scattering analysis is described in details. Update equations for boundary conditions of a perfectly conducting (PEC) interface and a dielectric interface are formulated and obtained in explicit forms. Numerical analyses of electromagnetic scatterings of PEC sphere, dielectric sphere and PEC cube are performed and the scattering coefficient is calculated and compared with the Mie's analytic results. As a result, the scattering coefficients show good agreement with the Mie's results, which demonstrates the validity of the CIP method and the formulated update equations. It is also shown that the phase of the scattering coefficients determined by the CIP method are slightly more accurate than that of the FDTD method.
Glyoxylic Acid (2001)

[298-12-4] C2H2O3 (MW 74.04) InChI = 1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5) InChIKey = HHLFWLYXYJOTON-UHFFFAOYSA-N (formaldehyde equivalent in Mannich reaction; reagent and its esters undergo a variety of additions, condensations, and Diels–Alder reactions) Alternate Name: glyoxalic acid; oxoacetic acid. Physical Data: deliquescent prisms; mp 98 °C (anhydrous), 50–52 °C (monohydrate); pKa 2.32. Solubility: sparingly sol ether, alcohol, benzene; v sol water. Form Supplied in: crystalline solid as monohydrate [563-96-2] and in 50% aqueous solution. Preparative Methods: glyoxylic acid is widely available, but the methyl, ethyl, and benzyl esters can be made easily from the ozonolysis of the corresponding maleate and fumarate esters.1 Purification: crystallized from water as the monohydrate. Handling, Storage, and Precautions: corrosive and hygroscopic.
The salutary effects of diphenyldifluoroketone EF24 in liver of a rat hemorrhagic shock model (2015)

Even in the absence of volume support, EF24 treatment suppresses pro-inflammatory signaling in liver tissue and improves liver functional markers in hemorrhagic shock.
21st‐century biogeochemical modeling: Challenges for Century‐based models and where do we go from here? (2020)

Abstract 21st‐century modeling of greenhouse gas (GHG) emissions from bioenergy crops is necessary to quantify the extent to which bioenergy production can mitigate climate change. For over 30 years, the Century‐based biogeochemical models have provided the preeminent framework for belowground carbon and nitrogen cycling in ecosystem and earth system models. While monthly Century and the daily time‐step version of Century (DayCent) have advanced our ability to predict the sustainability of bioenergy crop production, new advances in feedstock generation, and our empirical understanding of sources and sinks of GHGs in soils call for a re‐visitation of DayCent's core model structures. Here, we evaluate current challenges with modeling soil carbon dynamics, trace gas fluxes, and drought and age‐related impacts on bioenergy crop productivity. We propose coupling a microbial process‐based soil organic carbon and nitrogen model with DayCent to improve soil carbon dynamics. We describe recent improvements to DayCent for simulating unique plant structural and physiological attributes of perennial bioenergy grasses. Finally, we propose a method for using machine learning to identify key parameters for simulating N 2 O emissions. Our efforts are focused on meeting the needs for modeling bioenergy crops; however, many updates reviewed and suggested to DayCent will be broadly applicable to other systems.
ChemInform Abstract: CYCLOADDITION REACTIONS OF AZLACTONE (2,4‐DIPHENYL‐Δ2‐OXAZOLIN‐5‐ONE) WITH CINNAMALDEHYDE ANILS (1981)

Abstract Die Umsetzung der ungesättigten Anile (II) mit dem Azlacton (I) erfolgt nicht im Sinne einer Cycloaddition, sondern unter Michael‐Addition zu den Enaminen (III).
Hedef Kurami Kapsaminda Beklenen ve Gerçekleşen Yönetici Davranışları (2017)

Araştırmanın amacı motivasyon kuramlarından hedef belirleme kuramı çerçevesinde okul yöneticisinden beklenen davranışlar ile gerçekleştirdikleri davranışları öğretmenlerin görüşlerine dayalı olarak belirleyebilmektir. Bu çalışmada nitel araştırma yöntemi kullanılmıştır. Çalışma grubunun belirlenmesinde amaçlı örnekleme yöntemi ve buna bağlı olarak maksimum çeşitlilik ve ölçüt örnekleme teknikleri kullanılmıştır. 2013-2014 eğitim öğretim yılında Sinop ve Düzce illerinde yüksek lisans yapan veya yüksek lisans mezunu 42 öğretmen katılımcı olarak belirlenmiştir. Araştırmada, araştırmacılar tarafından geliştirilmiş yarı yapılandırılmış görüşme formu kullanılmıştır. Verilerin analizinde nitel veri çözümleme tekniği olarak içerik analiz kullanılmıştır. Katılımcı öğretmenlerin çoğu, zor hedeflerin kolay hedeflere göre daha yüksek performans sağlayacağını ve zor hedefler için yüksek performans göstereceklerini ifade etmişlerdir. Araştırmanın bir diğer sonucuna göre katılımcılardan belirgin hedeflerin daha doğru olacağını ifade edenlerin sayısı belirsiz hedeflerin doğru olacağını söyleyenlerin yaklaşık olarak iki katıdır. Aynı zamanda, yöneticilerin zor hedef belirlediğinde bunları gerçekleştirmek için öğretmenler daha fazla gayret göstermektedirler. Hedeflere ulaşılıp ulaşılmadığına dair yöneticilerin geri bildirim yaparken sadece olumsuz değil olumlu ve öğretmeni motive edici geri bildirim de yapması gerektiğini, hedeflerin değerlendirilmesinde yöneticinin de yapıcı değerlendirmeleriyle öğretmenin yaptıklarını takdir etmesi gerektiğini ifade etmişlerdir. Hedeflere ulaşılıp ulaşılmadığına dair yöneticiden geri bildirip alınıp alınmadığı ve buna gerek olup olmadığına dair sorulan soruya katılımcıların yarısı dönüt aldıklarını, üçte biri dönüt alamadıklarını ancak buna gerek olduğunu ifade etmişlerdir. Katılımcıların sadece çok az bir kısmı geri bildirime gerek olmadığını belirtmişlerdir. Elde edilen araştırma sonuçları hedef kuramı teorisi ilkeleri ile paralellik göstermektedir.
Reduction of Right Ventricular Pacing in Patients with Sinus Node Dysfunction Using an Enhanced Search AV Algorithm (2005)

Substantial reduction in ventricular pacing can be achieved by allowing the AV interval parameters to extend beyond 300 ms using the ESAV algorithm. In patients with AV block, ESAV suspended and patients were paced at their nominal settings.
Reply: Limitations in the creation of an automatic diagnosis tool for dysgraphia (2019)

CHILI
Metathesis catalysts and methods thereof (2023)

The present application provides, among other things, novel compounds for metathesis reactions, and methods for preparing and using provided compounds. In some embodiments, the present invention provides compounds having the structure of formula I or II. In some embodiments, the present invention provides methods for preparing a compound of formula I or II. In some embodiments, the present invention provides methods for using a provided compound. In some embodiments, a provided compound is useful for stereoselective ring-opening metathesis polymerization. In some embodiments, a provided metathesis method provides cis and/or isotactic polymers.
Interfacial misfit dislocation array based growth of III-Sb active regions on GaAs/AlGaAs DBRs for high-power 2 μm VECSELs (2008)

This presentation will overview the growth of an IMF based VECSEL structure operating at 2 μm with an InGaSb QW active region (a<sub>0</sub> = 6.09 &angst;) on GaAs/AlGaAs distributed bragg reflectors (DBR) (a<sub>0</sub> = 5.65 &angst;). The use of the GaAs substrate instead of GaSb results in a significant reduction in the surface defect density while allowing the use of a mature GaAs/AlGaAs DBR technology. We shall provide photoluminescence results from 2 &mu;m IMF based active regions grown on GaAs substrates and compare the results with the same active regions grown on GaSb substrates. We shall also provide extensive transmission electron microscopy, surface morphology and high-resolution x-ray diffraction analysis of the material grown.
A Review on ZUPT-Aided Pedestrian Inertial Navigation (2020)

We present a review of studies that were conducted by the MicroSystems Laboratory at UC Irvine on ZUPT-aided pedestrian inertial navigation. Our most recent results include: adaptive ZUPT detection, IMU mounting position optimization, residual velocity characterization, IMU error calibration, and navigation error prediction. With all the efforts above, a robust and accurate ZUPT-aided pedestrian inertial navigation implementation was demonstrated. The navigation bias was reduced by 10×, and a position error of less than 1% of the total length of trajectory was demonstrated with an industrial-grade IMU.
Thermal to electricity conversion using thermal magnetic properties (2023)

A system for the generation of Electricity from Thermal Energy using the thermal magnetic properties of a Ferromagnetic, Electrically Conductive Material (FECM) in one or more Magnetic Fields. A FECM is exposed to one or more Magnetic Fields. Thermal Energy is applied to a portion of the FECM heating the FECM above its Curie Point. The FECM, now partially paramagnetic, moves under the force of the one or more Magnetic Fields. The movement of the FECM induces an electrical current through the FECM, generating Electricity.
High Dexterity ???Snake??? Robot for Intrapericardial Interventions (2006)

*Division of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA †Robotics Institute, Carnegie Mellon University, Pittsburgh, PA, e-mail: [email protected] MIRA (Minimally Invasive Robotics Association) 1st International Congress Innsbruck, Austria December 7th–10th, 2005
Display and Selection of scFv Antibodies on HEK-293T Cells (2009)

We describe a human cell display strategy to isolate high-affinity single-chain antibody fragments (scFvs) specific for CD22 for the treatment of B-cell malignancies. Our strategy uses flow cytometry and human embryonic kidney 293T (HEK-293T) cells that are widely used for transient protein expression. Flow cytometry enhances the screen's sensitivity thereby allowing us to isolate high-affinity scFvs. Using human cell display, one could isolate and engineer scFvs, single domains, Fabs, or whole IgGs for increased affinity and other biological functions.
Impact of Dynamic Exhaust Valve Modelling (2019)

A method developed in SAE 2019-01-0058 to correctfor deviations from quasi-steady exhaust valve flow isimplemented on a single-cylinder GT-Power modeland the effects on pumping work and blowdown pu ...
Arachidonic acid increases permeability of HBMEC monolayers via increased production of prostaglandin E2 (2013)

The blood‐brain barrier, formed by microvessel endothelial cells, is the restrictive barrier between the brain parenchyma and the circulating blood. Arachidonic acid (AA) is a conditionally essential polyunsaturated fatty acid [20:4(n‐6)] and a major constituent of brain lipids. In this study transport of AA in confluent monolayers of human brain microvessel endothelial cells (HBMEC) was examined. Addition of [3H]AA to the apical compartment of HBMEC confluent monolayers cultured on Transwell® inserts resulted in rapid incorporation of [3H]AA into the basolateral medium. Knock down of FATP‐1 or CD36 did not alter [3H]AA movement into the basolateral medium and this was due to a rapid generation of prostaglandin E2 (PGE2), an eicosanoid known to facilitate opening of the blood‐brain barrier. Disruption of HBMEC monolayers following AA exposure was confirmed by an increased movement of fluorescein‐labeled dextran from the apical to basolateral medium. HBMECs expressed PGE2 synthase, cyclooxygenase‐1 and ‐2, PGE2 receptors, tight junction proteins and prostaglandin transporters. Specific cyclooxygenase‐2 inhibitors attenuated the AA‐mediated increase in membrane permeability. The results indicate that AA increases the permeability of HBMEC monolayers via increased production of PGE2. [Funded by NSERC Canada; GMH is a Canada Research Chair in Molecular Cardiolipin Metabolism]
A novel method to include the free surface in a CFD model of jet injection into partially-baffled mixing vessels (2009)

A novel methodology that can be used to perform simulations of fluid jet injection into a mixing vessel with a deformed free surface is presented and validated. The idea is to first use a two-fluid model to determine the location and shape of the free surface, and then results from the simulation are used to generate a single-phase model that has the same free surface shape. Example simulations are performed using ANSYS CFX for a pilot-scale partially-baffled vessel. Application of the methodology in the study of reaction quenching is presented but it is believed that this methodology has many other possible applications involving fluid or solid injection.
Activation of Human Peripheral Blood Lymphocytes: Effect of Concanavalin A and Lipopolysaccharide on in Vitro Synthesis of DNA and Immunoglobulins (1980)

We studied the interaction of lipopolysaccharide (LPS) and concanavalin A (Con A) with regard to IgM and IgG production in in vitro cultures of human peripheral blood lymphocytes (PBL). In our system LPS alone over a wide range of concentrations did not stimulate detectable IgM or IgG production, while Con A at optimal (6 microgram/ml) and suboptimal (0.6 microgram/ml) mitogenic concentrations induced synthesis of small amounts of Ig. A marked enhancing effect was present when both Con A and LPS were added to the cultures. The different doses of LPS has similar effects on both classes of Ig, and typical dose-response curves were obtained. To evaluate the cellular basis of this synergism, the effect on cell proliferation was studied under identical experimental conditions in normal subjects and patients with X-linked agammaglobulinaemia (X-LA). Parallel cultures were set up after monocyte depletion by adherence on Petri dishes. On day 3, increasing doses of LPS were associated with progressive decreases in 3H-thymidine (3H-TdR) incorporation. Similar results were obtained with normal lymphocytes and those from X-LA patients. Monocyte depletion did not substantially alter the lymphocyte response pattern. The preferential induction of helper activities, either directly by helper stimulation or indirectly by suppressor inhibition, is suggested as a possible mechanism of the interaction observed.
Time-travel rephotography (2021)

Many historical people were only ever captured by old, faded, black and white photos, that are distorted due to the limitations of early cameras and the passage of time. This paper simulates traveling back in time with a modern camera to rephotograph famous subjects. Unlike conventional image restoration filters which apply independent operations like denoising, colorization, and superresolution, we leverage the StyleGAN2 framework to project old photos into the space of modern high-resolution photos, achieving all of these effects in a unified framework. A unique challenge with this approach is retaining the identity and pose of the subject in the original photo, while discarding the many artifacts frequently seen in low-quality antique photos. Our comparisons to current state-of-the-art restoration filters show significant improvements and compelling results for a variety of important historical people. Please go to &lt;u&gt;time-travel&lt;/u&gt;l&lt;u&gt;-rephotography.github.io&lt;/u&gt; for many more results.