gebhart/patrepeval huggingface dataset:
The assessment of vascular risk in men with erectile dysfunction: the role of the cardiologist and general physician (2013)

Erectile dysfunction (ED) and cardiovascular disease (CVD) share risk factors and frequently coexist, with endothelial dysfunction believed to be the pathophysiologic link. ED is common, affecting more than 70% of men with known CVD. In addition, clinical studies have demonstrated that ED in men with no known CVD often precedes a CVD event by 2-5 years. ED severity has been correlated with increasing plaque burden in patients with coronary artery disease. ED is an independent marker of increased CVD risk including all-cause and especially CVD mortality, particularly in men aged 30-60 years. Thus, ED identifies a window of opportunity for CVD risk mitigation. We recommend that a thorough history, physical exam (including visceral adiposity), assessment of ED severity and duration and evaluation including fasting plasma glucose, lipids, resting electrocardiogram, family history, lifestyle factors, serum creatinine (estimated glomerular filtration rate) and albumin:creatinine ratio, and determination of the presence or absence of the metabolic syndrome be performed to characterise cardiovascular risk in all men with ED. Assessment of testosterone levels should also be considered and biomarkers may help to further quantify risk, even though their roles in development of CVD have not been firmly established. Finally, we recommend that a question about ED be included in assessment of CVD risk in all men and be added to CVD risk assessment guidelines.
ChemInform Abstract: Supercritical CO2 as an Innovative Reaction Medium for Selective Oxidation (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
DEVELOPMENT OF INNOVATIVE OPTICAL GLASSES FOR PHOTONICS AT POLITECNICO DI TORINO : NOVEL SILICA AND TELLURITE GLASSES (2012)

Differential expression of the genes expressing Pap pili in Escherichia coli was suggested to involve mRNAs with different stabilities. As the result of a post-transcriptional processing event, a papA gene-specific mRNA product (mRNA-A) accumulates in large excess relative to the primary mRNA-BA transcript. Our results show that the processed product, mRNA-A, is a translationally active molecule and that it is generated from the mRNA-BA precursor by an RNaseE-dependent mechanism. The processing did not occur under non-permissive conditions in an E. coli rne mutant strain with a temperature-sensitive RNaseE. The endonuclease RNaseE was previously described as being chiefly involved in the processing of the 9S precursor of 5S rRNA. A comparison of nucleotide sequences of mRNA-BA and three other RNAs processed by RNAseE revealed a conserved motif around the cleavage sites. Mutations abolishing the activity of either of two other endoribonucleases, RNaseIII and RNaseP, did not affect the pap mRNA processing event. However, a conditional mutation in the ams locus, causing altered stability of bulk mRNA in E. coli, led to reduced pap mRNA processing in a manner similar to the effect caused by RNaseE deficiency. Our findings are consistent with the idea that ams is related/allelic to rne. Absence of the processing event in the RNaseE mutant (rne-3071) strain led to a four-fold stabilization of the mRNA-BA primary transcript. We conclude that the RNaseE-dependent processing event is the rate-limiting step in the decay of the papB-coding part of the primary transcript and in the production of the stable mRNA-A product.(ABSTRACT TRUNCATED AT 250 WORDS)
A flexible 8.5 MHz litz wire receive array for field-cycling imaging (2023)

<i>Objectives</i>. Low frequency coils present unique challenges as loop losses, component losses, and the supporting electronics can significantly degrade the signal-to-noise ratio (SNR). SNR may already be a limiting factor with MRI at low field (and frequency), therefore the minimization of additional loss is particularly important. If interactions between loops are managed, array coils can provide increased SNR, coverage, and potentially imaging speed. In this work, we investigate methods to characterise and preserve SNR from a low frequency coil array, allowing a more geometrically conforming array for quick, no-tune application with various anatomies.<i>Approach</i>. Single and multi-turn, 16.2 cm diameter litz wire loops were constructed and characterised for losses under various loading conditions. Low noise preamplifiers were acquired and characterized, as well as interfacing electronics were developed and evaluated. A bench level SNR test was implemented to observe the effects of tuning and loading on individual coils. The results were used to select a design for construction of a 6-channel, flex array coil.<i>Main results</i>. Ultra fine strand litz wire exhibited lower losses than equivalent diameter solid wire which should translate to improved SNR and provides the mechanical flexibility needed in a conforming array. Single turn loop losses were dominant under all loading conditions; however, 2 and 3 turn loops were body loss dominated under modest loading conditions. Preamplifier blocking achieved was well short of our design goal and critical overlaps became necessary for coil-to-coil interaction control. Our finished array, a 3-channel posterior array coil and a 3-channel anterior array coil, conforms nicely to various anatomies and is providing consistent results in various volunteer study trials.<i>Significance</i>. Receive coils are challenging at low fields as loop losses often limit the final SNR. This is exacerbated in an array coil as loops may be smaller and not coupled well to the body. In this work we have demonstrated that body loss dominance is possible with 16.2 cm loops at 8.5 MHz. We have optimized, built, and tested low noise interfacing electronics and characterized the SNR penalties as the tuning and loading is varied, a key parameter in a geometrically flexible array designed for rapid setup. The resultant 6-channel, general-purpose array is supporting various Field-Cycling Imaging studies where body habitus and anatomies require a flexible, adaptable array coil which can be quickly positioned and utilized.
A Practical Synthesis of the Dual Matrix Metalloprotease/Tumor Necrosis Factor Inhibitor MMP090 (2005)

A practical 9-step synthesis of the dual matrix metalloprotease/tumor necrosis factor inhibitor MMP090, trans-(R)-[[N-(4-ethoxyphenylsulfonyl)-N-(4-pyridinylmethyl)]amino]-N-hydroxy-4-propoxy cyclohexaneacetamide 10, was accomplished in 12% overall yield from d-4-hydroxyphenylglycine. Highlights include: (1) selective hydrogenation of d-hydroxyphenylglycine to afford predominantly the trans isomer without racemization; (2) virtually complete removal of the undesired cis diastereoisomer by fractional recrystallization of a TBS ether derivative of the functionalized cyclohexylglycine; (3) direct conversion of the TBS ether into the n-propyl ether in the presence of a catalytic amount of bismuth bromide in high yield; and (4) conversion of the carboxylic acid into the hydroxamic acid using an aqueous solution of hydroxylamine.
PERIPHERAL-TYPE BENZODIAZEPINE BINDING IN ALZHEIMER DISEASE (1988)

Peripheral-type benzodiazepine binding of [3H]Ro5-4864 at one, non-saturating concentration and activities of choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) were measured in 7 cortical areas from postmortem brains of 18 patients with Alzheimer disease (AD), 12 age-matched controls, and 15 miscellaneous neurological cases. None of the chemical measures showed significant correlation with age, sex, or postmortem delay. As expected, ChAT and AChE activities were closely correlated with one another overall and within the AD and control groups, and the mean values for the AD group were significantly less than those in the controls in each of the cortical regions examined. Specific binding site densities were very variable from brain to brain and did not correlate with ChAT in any group or overall. By analysis of variance, however, binding site densities in the AD group were significantly higher than those in the controls. This difference was statistically significant (p less than 0.05) in Broca's area and the precentral and postcentral gyri, but not in the temporal gyri which generally have greater neuronal loss in AD. Of the 15 miscellaneous neurological cases, the Parkinson patients (n = 3) showed significantly higher binding densities than the controls but the multiinfarct dementia group (n = 5) did not. Single cases of Shy-Drager syndrome and sleep apnea showed a majority of values more than 2 standard deviations above the control means.(ABSTRACT TRUNCATED AT 250 WORDS)
Structural properties of SrO thin films grown by molecular beam epitaxy on LaAlO3 substrates (2006)

SrO films were grown on LaAlO3 substrates by molecular beam epitaxy and characterized using reflection high-energy electron diffraction (RHEED) and x-ray diffraction (XRD). The evolution of the RHEED pattern is discussed as a function of film thickness. 500Å thick SrO films were relaxed and exhibited RHEED patterns indicative of an atomically smooth surface having uniform terrace heights. Films had the epitaxial relationship (001)SrO‖(001)LaAlO3; [010]SrO‖[110]LaAlO3. This 45° in-plane rotation minimizes mismatch and leads to films of high crystalline quality, as verified by Kikuchi lines in the RHEED patterns and narrow rocking curves of the (002) XRD peak.
Building temperature control: A passivity-based approach (2012)

This paper focuses on the temperature control in a multi-zone building. The lumped heat transfer model based on thermal resistance and capacitance is used to analyze the system dynamics and control strategy. The resulting thermal network, including the zones, walls, and ambient environment, may be represented as an undirected graph. The thermal capacitances are the nodes in the graph, connected by thermal resistances as links. We assume the temperature measurements and temperature control elements (heating and cooling) are collocated. We show that the resulting input/output system is strictly passive, and any passive output feedback controller may be used to improve the transient and steady state performance without affecting the closed loop stability. The storage functions associated with passive systems may be used to construct a Lyapunov function, to demonstrate closed loop stability and motivates the construction of an adaptive feedforward control. A four-room example is included to illustrate the performance of the proposed passivity based control strategy.
SMB gateway firewall implementation using a network processor (2010)

Small and Medium-size Business (SMB) gateway applications require low capital cost (CAPEX) and low operational cost (OPEX) while demanding a wide range of advanced functions. These include switching, routing, wifi capability, Power over Ethernet (PoE), analogue voice and fax support, VoIP/SIP and remote administration, in addition to complicated security functions – all integrated into a single platform.
Enantioselective formal synthesis of uleine alkaloids from phenylglycinol-derived bicyclic lactams (2004)

A two-step route for the enantioselective construction of the tetracyclic ring system of uleine alkaloids, involving the stereoselective conjugate addition of an appropriate indole-containing nucleophile to a chiral bicyclic delta-lactam and the subsequent cyclization on the indole 3-position of the resulting 4,5-disubstituted 2-piperidone, has culminated in the formal total synthesis of several alkaloids of this group.
Real scenario and simulations on GLOSA traffic light system for reduced CO2 emissions, waiting time and travel time (2015)

Cooperative ITS is enabling vehicles to communicate with the infrastructure to provide improvements in traffic control. A promising approach consists in anticipating the road profile and the upcoming dynamic events like traffic lights. This topic has been addressed in the French public project Co-Drive through functions developed by Valeo named Green Light Optimal Speed Advisor (GLOSA). The system advises the optimal speed to pass the next traffic light without stopping. This paper presents results of its performance in different scenarios through simulations and real driving measurements. A scaling is done in an urban area, with different penetration rates in vehicle and infrastructure equipment for vehicular communication. Our simulation results indicate that GLOSA can reduce CO2 emissions, waiting time and travel time, both in experimental conditions and in real traffic conditions.
MESOIONIC SYDNONE: A REVIEW IN THEIR CHEMICAL AND BIOLOGICAL PROPERTIES (2017)

Various literature sources have documented sydnones as important molecules with exclusive chemical properties and a wide spectrum of bioactivities. Sydnone can be defined as a five-membered pseudo-aromatic heterocyclic molecule. Classically, 1,2,3-oxadiazole forms the main skeleton of sydnone. The molecule has delocalized balanced positive and negative charges. The five annular atoms share the positive charge and the enolate-like exocyclic oxygen atom bears the negative charge. The hydrogen atom at the position C4 was proved to have acidic and nucleophilic functionalities making the sydnone ring reactive towards electrophilic reagents. These unique chemical features enable sydnones to interact with biomolecules resulting in important therapeutic effects like anticancer, antidiabetic, antimicrobial, antioxidant and anti-inflammatory. Consequently, we aim from the current article to review the available chemical and pharmacological information on sydnone and its derivatives.
MMJN: Multi-Modal Joint Networks for 3D Shape Recognition (2019)

3D shape recognition has attracted wide research attention in the field of multimedia and computer vision. With the recent advance of deep learning, various deep models with different representations have achieved the state-of-the-art performances. Among them, many modalities are proposed to represent 3D model, such as point cloud, multi-view, and PANORAMA-view. Based on these representations, many corresponding deep models have shown significant performances on 3D shape recognition. However, few work to considers utilizing the fusion information of multi-modal for 3D shape recognition. Since these different modalities represent the same 3D model, they should guide each other to get a better feature representation. In this paper, we propose a novel multi-modal joint network (MMJN) for 3D shape recognition, which can consider the correlation between two different modalities to extract the robust feature vector. More specifically, we propose a novel correlation loss which can utilize the correlation between different features extracted by different modality networks to increase the robustness of the feature representation. Finally, we utilize the late fusion method to fuse the multi-modal information for 3D model representation and recognition. Here, we define the weight of different modalities features based on the statistic method and utilize the advantages of different modalities to generate more robust feature. We evaluated the proposed method on the ModelNet40 dataset for 3D shape classification and retrieval tasks. Experimental results and comparisons with the state-of-the-art methods demonstrate the superiority of our approach.
Modeling of a saturated switched reluctance motor using an operating point analysis and the unsaturated torque equation (2003)

This paper describes torque production in a saturated switched reluctance motor (SRM). The paper begins by deriving the equations for torque if the SRM is unsaturated. It then develops an operating point model for torque in a saturated SRM using the unsaturated form of the torque equation. This results in a methodology which makes the control algorithms applicable to either saturated or unsaturated SRMs.
Internal reactions of ion–neutral complexes from some disubstituted protonated benzaldehydes and acetophenones (1988)

Abstract Protonated benzaldehydes ‘a’ and protonated acetophenones ‘b’, substituted by a methoxymethyl group, a hydroxy‐methyl group and a mercaptomethyl group, respectively, in position 3, in addition to a methoxymethyl side chain at position 5, have been prepared by electron impact induced dissociation from the corresponding benzylic alcohols. The spontaneous fragmentations of metastable ions of ‘a’ and ‘b’ have been investigated with the aid of specifically deuterated derivatives. Large signals arc observed for the loss of methanol induced by a proton migration across the aromatic ring. The competing loss of H 2 O and H 2 S, respectively, from the second side chain is less abundant, in agreement with the smaller PA's of HO and HS groups. The elimination of HCOX and CH 3 COX (X = OCH 3 , OH, SH), respectively, from ‘a’ and ‘b’ is also observed. The label distributions for these reactions are in agreement with a mechanism corresponding to an internal reaction of [CHO] + and [CH 3 CO] + , respectively, with the functional group of the side chains in an intermediary ion–neutral complex. In addition, fragmentations are observed arising from reactions between the two side chains at positions 3 and 5. The D labelling proves specific reactions without any H/D exchange and thus reaction channels separated from the methanol loss. The results are explained by internal ion‐molecule reactions in an intermediary ion‐neutral complex of a methoxymethyl cation, a hydroxymethyl cation and a mercaptomethyl cation, respectively, formed by a protolytic bond cleavage of the side chains.
Instant recovery for data center savings (2015)

Today's data centers routinely employ triple redundancy, i.e., each disk page of a database or of a key value store is stored three times (or even more, e.g., in database and file system backups). In contrast, writeahead logging can reduce the cost of database operations and of data centers, assuming suitable techniques for logging, log archiving, backing up, and recovery. The present paper summarizes our work todate on single-page repair, instant restart, and instant restore; it describes our techniques for self-repairing indexes, single-pass restore, and virtual backups; and outlines the opportunities for single-copy databases, for avoidance of ever taking a backup (full or incremental), yet for availability and reliability matching today's double- or triple-redundant data centers
[OP.7B.08] INFLUENCE OF GENDER ON THE RELATIONSHIPS BETWEEN NEW INDICES OF ADIPOSITY AND LEFT VENTRICULAR MASS AND HYPERTROPHY IN HYPERTENSIVE PATIENTS (2016)

Objective: The unfavourable effects of the association of obesity with hypertension on cardiac structure and function have been extensively studied. However, controversy still exists about the influence of gender on the relationship between obesity and left ventricular mass (LVM) and hypertrophy (LVH). Even if body mass index (BMI) and waist circumference (WC) are widely used as anthropometric predictors for cardiovascular diseases (CVD), their validity has been questioned. Recently, Body Shape Index (ABSI) and Body Roundness Index (BRI) were proposed as alternative measures of adiposity that may better reflect health status (1–2). Our study was aimed to assess the ability of ABSI and BRI in identifying LVH and to determine whether they are superior to BMI and WC. Moreover, the influence of gender on the relationships between all these indices of adiposity and LVM was also evaluated. Design and method: We enrolled 724 subjects with EH (mean age 45 ± 12 years, 63 % men) without cardiovascular complications. In all subjects the anthropometric indices (weight, height and waist circumference) and the routine biochemical parameters were determined. BMI, ABSI and BRI were calculated. Furthermore, all patients underwent a 24-h blood pressure monitoring and an echocardiogram. LVM was indexed for body surface area (LVMI) and for height2.7 (LVMH2.7). Results: The univariate correlations of LVMI and LVMH2.7 with the measures of adiposity evaluated are shown in the table 1. ROC curves analysis revealed that in overall population (table 2) and in men BRI has a greater ability to identify LVH defined as LVMH2.7 > 51 g/m2.7.Conclusions: Our results seems to suggest that in men, but not in women, the BRI has a greater sensitivity to detect LVH than ABSI and the traditional measures of adiposity.
Pharmaceutical Process Engineering (2001)

Summarizing fundamental engineering principles and operations critical to converting bulk pharmaceutical products into patient-ready and appropriate drug delivery dosage forms, Pharmaceutical Process Engineering facilitates comprehensive understanding of the practical aspects of drug production in an accessible, step-by-step format. It provides a pharmaceutical perspective on unit operations that improves communication among diverse professionals in the field-from pharmaceutical researchers to chemical and industrial engineers-and fully covers the relationship of pharmaceutical development to the application of key concepts and major unit operations in pharmaceutical engineering.
A Shared Carrier Reception and Processing Scheme for Compensating Frequency Offset and Phase Noise of Space-Division Multiplexed Signals over Multicore Fibers (2013)

We propose a noise resistant method to compensate frequency offset and phase noise based on shared carrier reception for SDM signals. We demonstrate improvement in the transmission of 112Gb/s PM-16QAM over 294km MCF.
A Ge/SiGe quantum well waveguide modulator monolithically integrated with SOI waveguides (2011)

We present a Ge/SiGe quantum well QCSE waveguide modulator that is monolithically integrated with SOI waveguides. The integrated device shows 3.2 dB contrast ratio with 1 V swing at 7.0 Gbps.
The protective effect of pollen extracts against allyl alcohol damage of the liver. (1985)

In male Wistar rats the hepatoprotective effect of pollen extracts (Cernitins) agains. orally introduced 1% allyl alcohol (0.4 ml per 100 g body weight) was investigated Cernitins were applied orally at 0.6, 24 and 30 h after allyl alcohol administration. After 48 h an autopsy was performed and blood was collected for biochemical tests. Liver damage was evaluated by measurement of aminotransferases (AspAT, AlAT) and alkaline phosphatase activity, total bilirubin level in the blood serum as well as by histological examination of the livers. Cernitins significantly reduced the serum enzymes elevations induced by allyl alcohol. The hepatoprotective properties of Cernitins were confirmed by histopathological studies.
Macromol. Mater. Eng. 6/2016 (2016)

Front Cover: A multilayer nanocoating composed of polyelectrolytes and carbon nanotubes is able to render polyurethane foam flame retardant. This cover image represents the potential to protect household furniture from fire using this simple water-based coating. Further details can be found in the article by Kevin M. Holder, Amanda A. Cain, Morgan G. Plummer, Bart E. Stevens, Patrick K. Odenborg, Alexander B. Morgan, and Jaime C. Grunlan* on page 665.
Polymerization in the liquid crystalline state of vinyl ether monomers (1993)

Liquid crystalline phenylbenzoate vinyl ether was polymerized cationically in both anisotropic and isotropic monomeric melts, using photochemical initiation by onium salts. High molecular mass polymers with a narrow molecular mass distribution (around 2) were produced by cationic polymerization at high temperatures ({<=}{degrees}C). The initial state of the monomer, nematic or isotropic, did not affect neither molecular mass, molecular mass distribution, nor polymerization rate. {sup 13}C-NMR studies show that the polymer formed is atactic. Ordered 30-50 {mu}m films were produced by polymerization of mesogenic vinyl ether monomers oriented in the nematic and smectic phase.