gebhart/patrepeval huggingface dataset:
Synthesis of .beta.-keto phosphonates from vinyl phosphates via a 1,3-phosphorus migration (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of .beta.-keto phosphonates from vinyl phosphates via a 1,3-phosphorus migrationTheodora Calogeropoulou, Gerald B. Hammond, and David F. WiemerCite this: J. Org. Chem. 1987, 52, 19, 4185–4190Publication Date (Print):September 1, 1987Publication History Published online1 May 2002Published inissue 1 September 1987https://pubs.acs.org/doi/10.1021/jo00228a008https://doi.org/10.1021/jo00228a008research-articleACS PublicationsRequest reuse permissionsArticle Views2047Altmetric-Citations87LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Simulation studies and modeling of Short Circuit current oscillations in IGBTs (2009)

During Short-Circuit (SC) operations, strong current oscillations of IGBTs can appear. Simulation studies also confirm this. No parasitic inductances are required for such oscillations. A simplified equivalent circuit of the device, which is basically an RC oscillator, is able to reproduce the oscillations. The occurrence of oscillations depends on the model parameters, which can be related to the device structure and other conditions such as the gate resistance value, gate biasing, and DC-link voltage. This paper also shows that application of basic system theory methods to AC small-signal device simulation results (frequency-domain analysis under small-signal conditions) is appropriate to analyze the stability range of the IGBT under Short-Circuit.
Macrophages involvement in neuroendocrine tumor behaviour and progression (2020)

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
Toll-like receptor 2 is critical for induction of Reg3β expression and intestinal clearance of Yersinia pseudotuberculosis (2009)

TLR2/REG3 beta is thus an essential component in conditioning epithelial defence signalling pathways against bacterial invasion.
Heme oxygenase-1 expression inhibits dendritic cell maturation and proinflammatory function but conserves IL-10 expression (2005)

Heme oxygenase-1 (HO-1) is an intracellular enzyme that degrades heme and inhibits immune responses and inflammation in vivo. In most cell types, HO-1 is inducible by inflammatory stimuli and oxidative stress. Here we demonstrate that human monocyte-derived immature dendritic cells (iDCs) and several but not all freshly isolated rat splenic DC subsets and rat bone marrow-derived iDCs, spontaneously express HO-1. HO-1 expression drastically decreases during human and rat DC maturation induced in vitro. In human tissues, iDCs also express HO-1, whereas mature DCs do not. Induction of HO-1 expression with cobalt protoporphyrin (CoPP) in human and rat DCs inhibits lipopolysaccharide (LPS)-induced phenotypic maturation and secretion of proinflammatory cytokines, resulting in the inhibition of alloreactive T-cell proliferation. CoPP-treated DCs, however, retain the ability to produce the anti-inflammatory cytokine interleukin 10 (IL-10). Reactive oxygen species induced by LPS in DCs were inhibited by induction of HO-1. In conclusion, we identify, for the first time, the capacity of HO-1 to block maturation of DCs and to inhibit proinflammatory and allogeneic immune responses while preserving IL-10 production. This novel immune function for HO-1 may be of interest for the inhibition of immune responses in autoimmune diseases, transplantation, and other conditions involving activation of the immune system.
Greedy Learning of Graphical Models with Small Girth (2013)

This paper develops two new greedy algorithms for learning the Markov graph of discrete probability distributions, from samples thereof.For finding the neighborhood of a node (i.e.variable), the simple, naive greedy algorithm iteratively adds the new node that gives the biggest improvement in prediction performance over the existing set.While fast to implement, this can yield incorrect graphs when there are many short cycles, as now the single node that gives the best prediction can be outside the neighborhood.Our new algorithms get around this in two different ways.The forward-backward greedy algorithm includes a deletion step, which goes back and prunes incorrect nodes that may have initially been added.The recursive greedy algorithm uses forward steps in a two-level process, running greedy iterations in an inner loop, but only including the final node.We show, both analytically and empirically, that these algorithms can learn graphs with small girth which other algorithms -both greedy, and those based on convex optimization -cannot.y∈Y |P (y) -Q(y)|. IV. GREEDY ALGORITHMSIn this section we describe two new greedy algorithms for learning the structure of a MRF.
Antigen‐specific T cell suppressor factor (TsF): isolation of a cDNA clone encoding for a functional polypeptide chain of phosphorylcholine‐specific TsF (1985)

A cDNA library of phosphorylcholine (PC)-specific suppressor T hybridoma, 29-C-6, was constructed. By differential colony hybridization, 68 colonies were selected which hybridized with mRNA probes of two PC-specific suppressor T hybridomas, 29-C-6 and 09-M-24-8, but not with those of BW5147. A hybridization translation assay revealed that only one combination of translation products of cDNA clones, p6-1 and p6-5, showed strong PC-T cell suppressor factor (TsF) activity. Sequence analysis showed that p6-5 contained a specific cDNA sequence of about 800 base pairs (bp) while p6-1 had a 190 bp poly(A) sequence insert. When total poly(A) + RNA of 29-C-6 was hybridized with p6-1 filter alone the recovered mRNA was capable of producing PC-TsF. However, when the total poly-(A) + RNA was hybridized with a p6-1 filter combined with a p6-5 filter, the mRNA eluted from the p6-1 filter was not able to produce PC-TsF, suggesting that the depletion of p6-5 specific mRNA from p6-1-binding poly(A) + RNA led to a complete abolishment of the capability to produce PC-TsF. Furthermore, p6-5 hybridizing mRNA could successfully restore the p6-1-binding poly(A) + RNA depleted of p6-5-specific mRNA, and translation products of both RNA mixtures showed strong PC-TsF activity. These results suggest that PC-TsF is not a single polypeptide chain, but is composed of at least two distinct polypeptide chains, and also that p6-5 contains a cDNA sequence encoding for one of the polypeptide chains composing the PC-TsF molecule.
Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy (2020)

The reliance of many cancers on aerobic glycolysis has stimulated efforts to develop lactate dehydrogenase (LDH) inhibitors. However, despite significant efforts, LDH inhibitors (LDHi) with sufficient specificity and in vivo activity to determine whether LDH is a feasible drug target are lacking. We describe an LDHi with potent, on-target, in vivo activity. Using hyperpolarized magnetic resonance spectroscopic imaging (HP-MRSI), we demonstrate in vivo LDH inhibition in two glycolytic cancer models, MIA PaCa-2 and HT29, and we correlate depth and duration of LDH inhibition with direct anti-tumor activity. HP-MRSI also reveals a metabolic rewiring that occurs in vivo within 30 min of LDH inhibition, wherein pyruvate in a tumor is redirected toward mitochondrial metabolism. Using HP-MRSI, we show that inhibition of mitochondrial complex 1 rapidly redirects tumor pyruvate toward lactate. Inhibition of both mitochondrial complex 1 and LDH suppresses metabolic plasticity, causing metabolic quiescence in vitro and tumor growth inhibition in vivo.
Genomewide Location Analysis of Candida albicans Upc2p, a Regulator of Sterol Metabolism and Azole Drug Resistance (2008)

Upc2p, a transcription factor of the zinc cluster family, is an important regulator of sterol biosynthesis and azole drug resistance in Candida albicans. To better understand Upc2p function in C. albicans, we used genomewide location profiling to identify the transcriptional targets of Upc2p in vivo. A triple hemagglutinin epitope, introduced at the C terminus of Upc2p, conferred a gain-of-function effect on the fusion protein. Location profiling identified 202 bound promoters (P < 0.05). Overrepresented functional groups of genes whose promoters were bound by Upc2p included 12 genes involved in ergosterol biosynthesis (NCP1, ERG11, ERG2, and others), 18 genes encoding ribosomal subunits (RPS30, RPL32, RPL12, and others), 3 genes encoding drug transporters (CDR1, MDR1, and YOR1), 4 genes encoding transcription factors (INO2, ACE2, SUT1, and UPC2), and 6 genes involved in sulfur amino acid metabolism (MET6, SAM2, SAH1, and others). Bioinformatic analyses suggested that Upc2p binds to the DNA motif 5'-VNCGBDTR that includes the previously characterized Upc2p binding site 5'-TCGTATA. Northern blot analysis showed that increased binding correlates with increased expression for the analyzed Upc2p targets (ERG11, MDR1, CDR1, YOR1, SUT1, SMF12, and CBP1). The analysis of ERG11, MDR1, and CDR1 transcripts in wild-type and upc2Delta/upc2Delta strains grown under Upc2p-activating conditions (lovastatin treatment and hypoxia) showed that Upc2p regulates its targets in a complex manner, acting as an activator or as a repressor depending upon the target and the activating condition. Taken together, our results indicate that Upc2p is a key regulator of ergosterol metabolism. They also suggest that Upc2p may contribute to azole resistance by regulating the expression of drug efflux pump-encoding genes in addition to ergosterol biosynthesis genes.
Demo (2016)

Nearly every setting is increasingly populated with wireless and mobile devices -- whether appliances in a home, medical devices in a health clinic, sensors in an industrial setting, or devices in an office or school. There are three fundamental operations when bringing a new device into any of these settings: (1) to configure the device to join the wireless local-area network, (2) to partner the device with other nearby devices so they can work together, and (3) to configure the device so it connects to the relevant individual or organizational account in the cloud. The challenge is to accomplish all three goals simply, securely, and consistent with user intent. We developed Wanda -- a `magic wand' that accomplishes all three of the above goals -- and will demonstrate a prototype implementation.
Design, FEA and Dynamic Simulation of a New Unconventional9-Phase PMSM with Asymmetric Winding (2018)

In this paper, finite element analysis and dynamic simulations are performed for an unconventional asymmetric winding nine phase permanent magnet synchronous motor. Motor parameters such as back electromotive force voltages, cogging torque and output torque values are obtained by finite element analysis and compared with experimental results in terms of back electromotive force and output torque signals. A brief mathematical expressions are also presented for the 9-phase permanent magnet motor and simulation study is implemented based on these equations. A comparison between the simulations, finite element analysis and test results is also presented for such an unconventional PM motor in the paper.
Safety Studies on Intravenous Administration of Oncolytic Recombinant Vesicular Stomatitis Virus in Purpose-Bred Beagle Dogs (2013)

VSV-IFNβ-NIS is a novel recombinant oncolytic vesicular stomatitis virus (VSV) with documented efficacy and safety in preclinical murine models of cancer. To facilitate clinical translation of this promising oncolytic therapy in patients with disseminated cancer, we are utilizing a comparative oncology approach to gather data describing the safety and efficacy of systemic VSV-IFNβ-NIS administration in dogs with naturally occurring cancer. In support of this, we executed a dose-escalation study in purpose-bred dogs to determine the maximum tolerated dose (MTD) of systemic VSV-hIFNβ-NIS, characterize the adverse event profile, and describe routes and duration of viral shedding in healthy, immune-competent dogs. The data indicate that an intravenous dose of 10(10) TCID50 is well tolerated in dogs. Expected adverse events were mild to moderate fever, self-limiting nausea and vomiting, lymphopenia, and oral mucosal lesions. Unexpected adverse events included prolongation of partial thromboplastin time, development of bacterial urinary tract infection, and scrotal dermatitis, and in one dog receiving 10(11) TCID50 (10 × the MTD), the development of severe hepatotoxicity and symptoms of shock leading to euthanasia. Viral shedding data indicate that detectable viral genome in blood diminishes rapidly with anti-VSV neutralizing antibodies detectable in blood as early as day 5 postintravenous virus administration. While low levels of viral genome copies were detectable in plasma, urine, and buccal swabs of dogs treated at the MTD, no infectious virus was detectable in plasma, urine, or buccal swabs at any of the doses tested. These studies confirm that VSV can be safely administered systemically in dogs, justifying the use of oncolytic VSV as a novel therapy for the treatment of canine cancer.
MAP reconstruction from spatially correlated PET data (2003)

High sensitivity 3-D PET data is often rebinned into 2-D data sets in order to reduce the computation time of reconstructions. The need to precorrect the 3-D data for attenuation, accidentals, scatter, and deadtime effects before rebinning along with the rebinning process itself changes the statistics of the data. This paper presents an approach for finding and using the statistics of Fourier rebinned (FORE) data. In particular, utilizing a space domain representation of FORE, we find the approximate covariance matrix. We also derive an improved estimate of the mean of the rebinned data with a 2-D forward projector that more accurately represents the effect of FORE on the original 3-D PET measurements. In order to incorporate dependent information, we model the data conditioned on the image as a low-order Markov field. This model is based on a quadratic approximation of the log-likelihood of dependent 2-D PET data. The dependence relationship is then incorporated into a novel maximum a posteriori (MAP) 2-D reconstruction method. Initial results show that this method offers modest MSE improvements with a reference image over Poisson-based MAP methods. Results also reveal that the use of only the improved mean leads to significant improvements in reconstructions from FORE data.
From the Representativeness of Sampled Odors to an Olfactive Camera (2019)

Although representativeness is often a prerequisite when sampling odors, the methods used have never been assessed from the analytical and sensory perspective simultaneously. We validate several critical innovations in the methods used to sample odors, starting with a previously developed static-and-trapped headspace (S&T-HS) cell, to minimize sorptive biases and allow for thermodesorption of trapped odors. The addition of a desorption oven allows for restoration and testing of odors sampled by not only S&T-HS but also other techniques (solid-phase microextraction, headspace sorptive extraction, purge-and-trap headspace). The S&T-HS cell exhibits satisfactory representativeness, much higher than the three other techniques. This allows, for the first time, a proposal to use this technology as an olfactive camera to capture and restore an odor. The method was tested on a sample of a complex fresh ashtray odor.
75As NMR study of the growth of paramagnetic-metal domains due to electron doping near the superconducting phase in LaFeAsO1−xFx (2012)

We studied the electric and magnetic behavior near the phase boundary between antiferromagnetic (AF) and superconducting phases for a prototype of high-${T}_{c}$ pnictides LaFeAsO${}_{1\ensuremath{-}x}$F${}_{x}$ by using nuclear magnetic resonance, and found that paramagnetic-metal (PM) domains segregate from AF domains. PM domains grow in size with increasing electron doping level and are accompanied by the onset of superconductivity, and thus the application of pressure or increasing the doping level causes superconductivity. The existence of PM domains cannot be explained by the existing paradigm that focuses only on the relationship between superconductivity and antiferromagnetism. Based on orbital fluctuation theory, the existence of PM domains is evidence of the ferroquadrupole state.
Provenance and Logging for Sense Making (Dagstuhl Seminar 18462) (2019)

Sense making is one of the biggest challenges in data analysis faced by both the industry and the research community. It involves understanding the data and uncovering its model, generating a hypothesis, selecting analysis methods, creating novel solutions, designing evaluation, and also critical thinking and learning wherever needed. The research and development for such sense making tasks lags far behind the fast-changing user needs, such as those that emerged recently as the result of so-called "Big Data". As a result, sense making is often performed manually and the limited human cognition capability becomes the bottleneck of sense making in data analysis and decision making. One of the recent advances in sense making research is the capture, visualization, and analysis of provenance information. Provenance is the history and context of sense making, including the data/analysis used and the users' critical thinking process. It has been shown that provenance can effectively support many sense making tasks. For instance, provenance can provide an overview of what has been examined and reveal gaps like unexplored information or solution possibilities. Besides, provenance can support collaborative sense making and communication by sharing the rich context of the sense making process. Besides data analysis and decision making, provenance has been studied in many other fields, sometimes under different names, for different types of sense making. For example, the Human-Computer Interaction community relies on the analysis of logging to understand user behaviors and intentions; the WWW and database community has been working on data lineage to understand uncertainty and trustworthiness; and finally, reproducible science heavily relies on provenance to improve the reliability and efficiency of scientific research. This Dagstuhl Seminar brought together researchers from the diverse fields that relate to provenance and sense making to foster cross-community collaboration. Shared challenges were identified and progress has been made towards developing novel solutions.
Study on Co–Cr Alloy Cluster Assembling Process by Magneto-Optical Kerr Effect (1999)

Nanometric Co–10at% Cr alloy-cluster assembled films have been produced by a plasma-gas-condensation method, and examined by transmission electron microscopy and the magneto-optical Kerr effect. With increasing the average weight thickness t we found that the Co–Cr clusters coalesce to form a large network. This formation took place more rapidly among clusters with an average cluster size of d = 2.4 nm than with those of d = 4.6 nm. The isolated Co–Cr clusters are superparamagnetic when t < 2 nm. With increasing t, the transition from superparamagnet to ferromagnet occurs more rapidly in the system with d = 2.4 nm than in that with d = 4.6 nm, in accordance with their morphological characteristics.
Flowing Lattices of Bubbles as Tunable, Self‐Assembled Diffraction Gratings (2006)

We demonstrate tunable, fluidic, two-dimensional diffraction gratings based on a microfluidic platform comprising a flow-focusing bubble generator and flowing, regular lattices of bubbles formed by dynamic self-assembly. The structure of these lattices can be tuned with switching times of less than ten seconds by changing the pressures and rates of flow applied to the device. These diffraction gratings exhibit high stability (over hours of operation if properly designed and operated). For our devices, we achieved tunable ranges in pitch from 12 to 51 microm, corresponding to first-order diffraction angles from 3.2 degrees to 0.7 degrees for light with a wavelength of 632 nm.
Optical limiting in solid-core photonic crystal fibers (2007)

Optical limiting in solid-core photonic crystal fibers filled with reverse-saturable absorbers has been observed. A sharp change in limiting threshold was found for materials in the fiber holes with refractive indices near n = 1.44.
Supplementary Figures S1 - S5 from Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting (2023)

&lt;p&gt;Supplementary Figure S1. Genome-scale CRISPR-Cas9 screening identifies a strong correlation between copy number and sensitivity to CRISPR-Cas9 genome editing. Supplementary Figure S2. Global summary of the relationship of CRISPR-Cas9 guide scores to genomic copy number for all 33 cell lines screened. Supplementary Figure S3. Amplified genes represent the strongest perceived dependencies in pooled CRISPR-Cas9 screening data. Figure S4. Evaluation of the influence of copy number on CRISPR-Cas9 dependency scores in published data from Hart et al. (25). Figure S5. Representative examples of structural variations leading to copy number amplification underlying the gene-independent anti-proliferative response to CRISPRCas9 targeting of loci within these regions.&lt;/p&gt;
Combination of Alcohol and EVOH as a New Embolic Agent: Midterm Tissue and Inflammatory Effects in a Swine Model (2020)

AS18 can suggest a better distal sclerotic and embolic character as compared with S18® alone without systemic toxicity.
Time-reversed acoustics in random media and in chaotic cavities (2001)

The objective of this paper is to show that time reversal invariance can be exploited in acoustics to accurately control wave propagation through propagating media whose ray dynamics is chaotic. To illustrate these concepts, several experiments conducted with `time reversal mirrors' are presented. They show that chaotic dynamics reduces the number of reversible transducers needed to ensure an accurate time reversal experiment. Multiple scattering in random media and reverberation in chaotic cavities enhance resolution in time reversal acoustics by making the effective size of time reversal mirrors much larger than their physical size. Comparisons with phase-conjugated experiments will show that this effect is typical of broadband time-reversed acoustics and is not observed in monochromatic phase conjugation. Self-averaging properties of time reversal experiments conducted in chaotic scattering environments will be emphasized.