gebhart/patrepeval huggingface dataset:
Dorsal spinal cord stimulation obtunds the capacity of intrathoracic extracardiac neurons to transduce myocardial ischemia (2009)

Populations of intrathoracic extracardiac neurons transduce myocardial ischemia, thereby contributing to sympathetic control of regional cardiac indices during such pathology. Our objective was to determine whether electrical neuromodulation using spinal cord stimulation (SCS) modulates such local reflex control. In 10 anesthetized canines, middle cervical ganglion neurons were identified that transduce the ventricular milieu. Their capacity to transduce a global (rapid ventricular pacing) vs. regional (transient regional ischemia) ventricular stress was tested before and during SCS (50 Hz, 0.2 ms duration at 90% MT) applied to the dorsal aspect of the T1 to T4 spinal cord. Rapid ventricular pacing and transient myocardial ischemia both activated cardiac-related middle cervical ganglion neurons. SCS obtunded their capacity to reflexly respond to the regional ventricular ischemia, but not rapid ventricular pacing. In conclusion, spinal cord inputs to the intrathoracic extracardiac nervous system obtund the latter's capacity to transduce regional ventricular ischemia, but not global cardiac stress. Given the substantial body of literature indicating the adverse consequences of excessive adrenergic neuronal excitation on cardiac function, these data delineate the intrathoracic extracardiac nervous system as a potential target for neuromodulation therapy in minimizing such effects.
Gastrointestinal Blood Flow (2008)

This chapter contains sections titled: Anatomy of the gastrointestinal circulation Mechanisms of blood flow regulation Postprandial hyperemia Interactions between gastrointestinal and liver circulations Physiology and biochemistry of ischemia The newborn intestinal circulation References
Orthogonal analytical approaches to detect potential contaminants in heparin (2009)

Heparin is a widely used anticoagulant and antithrombotic agent. Recently, a contaminant, oversulfated chondroitin sulfate (OSCS), was discovered within heparin preparations. The presence of OSCS within heparin likely led to clinical manifestations, most prevalently, hypotension and abdominal pain leading to the deaths of several dozens of patients. Given the biological effects of OSCS, one continuing item of concern is the ability for existing methods to identify other persulfonated polysaccharide compounds that would also have anticoagulant activity and would likely elicit a similar activation of the contact system. To complete a more extensive analysis of the ability for NMR and capillary electrophoresis (CE) to capture a broader array of potential contaminants within heparin, we completed a systematic study of NMR, both mono- and bidimensional, and CE to detect both various components of sidestream heparin and their persulfonated derivatives. We show that given the complexity of heparin samples, and the requirement to ensure their purity and safety, use of orthogonal analytical techniques is effective at detecting an array of potential contaminants that could be present.
Nontypeable Haemophilus influenzae Has Evolved Preferential Use of N- Acetylneuraminic Acid as a Host Adaptation (2019)

Nontypeable <i>Haemophilus inﬂuenzae</i> (NTHi) is a Gram-negative bacterial pathogen that is adapted exclusively to human hosts. NTHi utilizes sialic acid from the host as a carbon source and as a terminal sugar on the outer membrane glycolipid lipooligosaccharide (LOS). Sialic acid expressed on LOS is critical in NTHi biofilm formation and immune evasion. There are two major forms of sialic acids in most mammals, <i>N</i>-acetylneuraminic acid (Neu5Ac) and <i>N</i>-glycolylneuraminic acid (Neu5Gc), the latter of which is derived from Neu5Ac. Humans lack the enzyme to convert Neu5Ac to Neu5Gc and do not express Neu5Gc in normal tissues; instead, Neu5Gc is recognized as a foreign antigen. A recent study showed that dietary Neu5Gc can be acquired by NTHi colonizing humans and then presented on LOS, which acts as an antigen for the initial induction of anti-Neu5Gc antibodies. Here we examined Neu5Gc uptake and presentation on NTHi LOS. We show that, although Neu5Gc and Neu5Ac are utilized equally well as sole carbon sources, Neu5Gc is not incorporated efficiently into LOS. When equal amounts of Neu5Gc and Neu5Ac are provided in culture media, there is ∼4-fold more Neu5Ac incorporated into LOS, suggesting a bias in a step of the LOS biosynthetic pathway. CMP-Neu5Ac synthetase (SiaB) was shown to have ∼4,000-fold-higher catalytic efficiency for Neu5Ac than for Neu5Gc. These data suggest that NTHi has adapted preferential utilization of Neu5Ac, thus avoiding presentation of the nonhuman Neu5Gc in the bacterial cell surface. The selective pressure for this adaptation may represent the human antibody response to the Neu5Gc xenoantigen.<b>IMPORTANCE</b> Host-adapted bacterial pathogens such as NTHi cannot survive out of their host environment and have evolved host-specific mechanisms to obtain nutrients and evade the immune response. Relatively few of these host adaptations have been characterized at the molecular level. NTHi utilizes sialic acid as a nutrient and also incorporates this sugar into LOS, which is important in biofilm formation and immune evasion. In the present study, we showed that NTHi has evolved to preferentially utilize the Neu5Ac form of sialic acid. This adaptation is due to the substrate preference of the enzyme CMP-Neu5Ac synthetase, which synthesizes the activated form of Neu5Ac for macromolecule biosynthesis. This adaptation allows NTHi to evade killing by a human antibody response against the nonhuman sialic acid Neu5Gc.
Supplementary Figure 1 from Dual mTORC1/2 and HER2 Blockade Results in Antitumor Activity in Preclinical Models of Breast Cancer Resistant to Anti-HER2 Therapy (2023)

&lt;p&gt;PDF file, 760KB, Biochemical analyses of trastuzumab/lapatinib sensitive cells treated with lapatinib.&lt;/p&gt;
Strong Inhibition of Xenografted Tumor Growth by Low-Level Doses of [32P]ATP (2011)

The ability of a potential human anti-cancer therapeutic agent to inhibit the growth of xenografted tumors in nude mice has been an established and accepted testing method for several decades. The current report shows that a single, low-level intravenous dose of [(32)P]ATP significantly inhibits the growth of established xenografted tumors in nude mice. This inhibitory effect becomes appreciable very rapidly, within only five days post-injection and the low dose demonstrates little or no toxicity in the mice. Surprisingly, a narrow dose window of optimum effectiveness is seen, whereby either decreasing or increasing the [(32)P]ATP dose results in far less growth inhibition. Thus, the intravenous systemic injection of [(32)P]ATP may represent a simple, potent method to target and inhibit primary human tumors and malignant lesions.
In-vivo orthopedic implant diagnostic device for sensing load, wear, and infection (2023)

A device for providing in vivo diagnostics of loads, wear, and infection in orthopedic implants having at least one load sensor associated with the implant, at least one temperature sensor associated with the implant, at least one vibration sensor associated with the implant, and at least one signal processing device operatively coupled with the sensors. The signal processing device is operable to receive the output signal from the sensors and transmit a signal corresponding with the output signal.
Overshoot Mitigation Using the Reference Governor Framework (2020)

This letter presents a novel reference governor scheme for overshoot mitigation in a tracking control system. Our proposed scheme, referred to as the Reference Governor with Dynamic Constraint (RG-DC), recasts the overshoot mitigation problem as a constraint management problem. The outcome of this reformulation is a dynamic Maximal Admissible Set (MAS), which varies in real-time as a function of the reference signal. The RG-DC employs the dynamic MAS, as well as a novel switching logic, to modify the reference signal to prevent or mitigate overshoot. We present several properties of the dynamic MAS and the algorithms required to compute it. We also investigate the stability and recursive feasibility of the RG-DC. Simulation results demonstrate the efficacy of the approach, and also highlight its limitations.
Regional Distribution of Neuritic Plaques in the Nondemented Elderly and Subjects With Very Mild Alzheimer Disease (1998)

These findings are consistent with the hypothesis that NPs are among the earliest neuropathological lesions in AD. Even very mild or questionable dementia is associated with increased density of neocortical NPs that do not distinguish between clinically questionable vs definite dementia.
InstillationversusInhalation of Multiwalled Carbon Nanotubes: Exposure-Related Health Effects, Clearance, and the Role of Particle Characteristics (2014)

Inhaled multiwalled carbon nanotubes (MWCNTs) may cause adverse pulmonary responses due to their nanoscale, fibrous morphology and/or biopersistance. This study tested multiple factors (dose, time, physicochemical characteristics, and administration method) shown to affect MWCNT toxicity with the hypothesis that these factors will influence significantly different responses upon MWCNT exposure. The study is unique in that (1) multiple administration methods were tested using particles from the same stock; (2) bulk MWCNT formulations had few differences (metal content, surface area/functionalization); and (3) MWCNT retention was quantified using a specialized approach for measuring unlabeled MWCNTs in rodent lungs. Male Sprague-Dawley rats were exposed to original (O), purified (P), and carboxylic acid functionalized (F) MWCNTs via intratracheal instillation and inhalation. Blood, bronchoalveolar lavage fluid (BALF), and lung tissues were collected at postexposure days 1 and 21 for quantifying biological responses and MWCNTs in lung tissues by programmed thermal analysis. At day 1, MWCNT instillation produced significant BALF neutrophilia and MWCNT-positive macrophages. Instilled O- and P-MWCNTs produced significant inflammation in lung tissues, which resolved by day 21 despite MWCNT retention. MWCNT inhalation produced no BALF neutrophilia and no significant histopathology past day 1. However, on days 1 and 21 postinhalation of nebulized MWCNTs, significantly increased numbers of MWCNT-positive macrophages were observed in BALF. Results suggest (1) MWCNTs produce transient inflammation if any despite persistence in the lungs; (2) instilled O-MWCNTs cause more inflammation than P- or F-MWCNTs; and (3) MWCNT suspension media produce strikingly different effects on physicochemical particle characteristics and pulmonary responses.
Production of liquid hydrocarbon fuels from peat (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTProduction of liquid hydrocarbon fuels from peatD. C. Elliott, E. G. Baker, J. Piskorz, D. S. Scott, and Y. SolantaustaCite this: Energy Fuels 1988, 2, 2, 234–235Publication Date (Print):March 1, 1988Publication History Published online1 May 2002Published inissue 1 March 1988https://pubs.acs.org/doi/10.1021/ef00008a023https://doi.org/10.1021/ef00008a023research-articleACS PublicationsRequest reuse permissionsArticle Views294Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Formation of Stable Interphase of Polymer-in-Salt Electrolyte in All-Solid-State Lithium Batteries (2020)

The integration of solid-polymer electrolytes into all-solid-state lithium batteries is highly desirable to overcome the limitations of current battery configurations that have a low energy density and severe safety concerns. Polyacrylonitrile is an appealing matrix for solid-polymer electrolytes; however, the practical utilization of such polymer electrolytes in all-solid-state cells is impeded by inferior ionic conductivity and instability against a lithium-metal anode. In this work, we show that a polymer-in-salt electrolyte based on polyacrylonitrile with a lithium salt as the major component exhibits a wide electrochemically stable window, a high ionic conductivity, and an increased lithium-ion transference number. The growth of dendrites from the lithium-metal anode was suppressed effectively by the polymer-in-salt electrolyte to increase the safety features of the batteries. In addition, we found that a stable interphase was formed between the lithium-metal anode and the polymer-in-salt electrolyte to restrain the uncontrolled parasitic reactions, and we demonstrated an all-solid-state battery configuration with a LiFePO 4 cathode and the polymer-in-salt electrolyte, which exhibited a superior cycling stability and rate capability.
An Opportunistic Medium Access Control Protocol for Visible Light Ad Hoc Networks (2018)

Visible Light Ad Hoc Networks (LANETs) have the potential to offer capabilities to satisfy growing industrial and military requirements, including low-latency, high bandwidth communication under high network density and jamming conditions. The challenges imposed by hidden nodes, deafness and blockage are unique to LANET and influence the network differently from traditional Mobile Ad Hoc Networks (MANETs) due to directionality and Line of Sight (LOS) requirements. Therefore, networking protocols have to be redesigned with careful consideration of these challenges. As an initial step in this direction, this paper proposes a utility based opportunistic three-way handshake mechanism to negotiate medium access. First, a node chooses the optimal transmission sector, i.e., the ”direction” that maximizes the probability of establishing a link even when some of the neighbors are affected by blockage or deafness. The utility function is designed to favor the establishment of full-duplex communication links. The full-duplex transmission or busy tone along with power control employed by the proposed Medium Access Control (MAC) protocol is aimed at mitigating the hidden node problem. All these factors contribute towards maximizing the throughput of LANET. Performance evaluation studies through extensive simulations show up to 61% increase in throughput and significant improvement in the number of full-duplex links established with respect to Carrier Sense Multiple Access/Collision Avoidance (CSMA/CA).
Increasing Durability of Flame-Sprayed Strain Gauges (2007)

Thermally sprayed dielectric ceramic coatings are the primary means of attaching strain and temperature gauges to hot-section rotating parts of turbine engines. As hot-section temperatures increase, lifetimes of installed gauges decrease, and seldom exceed one hour above 2,000 F (approx.1,100 C). Advanced engine components are expected to operate at temperatures approaching 2,200 F (approx.1,200 C), and the required high-temperature lifetime is 10 hours minimum. Typically, to enable a ceramic coating to adhere to the smooth surface of an engine component, a thermally sprayed NiCrAlY or NiCoCrAlY bond coat is applied to the smooth surface, thereby providing a textured surface to which the ceramic coat can adhere. The main failure mechanism of this system is decohesion and/or delamination at the interface between the ceramic top coat and the bond coat, caused by oxidation of the bond coat and stresses from the mismatch between the coefficients of thermal expansion of the ceramic top coat and the metallic bond coat. The approach taken to increase the high-temperature lifetime of a gauge attached to an engine component by the method described above involves (1) selective oxidation of the bond coat by means of a heat treatment in reduced oxygen partial pressure followed by (2) the application of a noble-metal diffusion barrier. In experiments to test this approach, heat treatments of NiCoCrAlY bond coats were carried out in a tube furnace in which, in each case, the temperature was alternately (1) increased at a rate of 3 C per minute and (2) held steady for one hour until the desired temperature was reached. The tube furnace was continuously purged with dry nitrogen gas. A final heat-treatment temperature range of 1,600 to 1,800 F (871 to 982 C) proved most beneficial.
Does Type I Interferon Limit Protective Neutrophil Responses during Pulmonary Francisella Tularensis Infection? (2014)

OPINION article Front. Immunol., 23 July 2014Sec. Microbial Immunology Volume 5 - 2014 | https://doi.org/10.3389/fimmu.2014.00355
A programmable architecture for the provision of hybrid services (1999)

The success of new service provision platforms will largely depend on their ability to blend with existing technologies. The advent of Internet telephony, although impressive, is unlikely to make telephone customers suddenly turn in favor of computers. Rather, customers display increasing interest in services that span multiple networks (especially Internet protocol-based networks and the telephone and cellular networks) and open new vistas. We refer to these services as hybrid services and propose an architecture for their provision. This architecture allows for programming the service platform elements (i.e., network nodes, gateways, control servers, and terminals) in order to include new service logics. We identify components that can be assembled to build these logics by considering a service as a composition of features such as address translation, security, call control, connectivity, charging, and user interaction. Generic service components are derived from the modeling of these features. We assure that our proposal can be implemented even in existing systems in return for slight changes. These systems are required to generate an event when a special service is encountered. The treatment of this event is handled by an object at a Java service layer. Java has been chosen for its platform-neutrality property and its embedded security mechanisms. Using our architecture, we design a hybrid closed user group service.
Metal Pipe Joining with Aluminum Alloy by Ultrasonic Insert Casting (2000)

Abstract Insert casting of aluminum is widely used in industry. In order to realize better metallurgical bonding between metallic pipe and aluminum alloy castings, a new insert casting method with aided by high-power ultrasound has been developed. The bonding strength between the metal pipe and the cast aluminum alloy was evaluated by shear testing, EPMA analysis at the bonding interface was performed. The experimental results indicate that the application of ultrasonic vibration was effective during insert casting, particularly immediately after the primary a phase began to emerge in the cast aluminum melt. In the case of 6061 Al pipe/AC4C joint, the shear strength was approximately 60 times higher than without ultrasound vibration. This bonding reflects the break up of the oxide film on the aluminum pipe surface by the ultrasound cavitation effect. For the steel pipe/AC4C joint, the bonding shear strength had a several-fold enhancement. Ultrasound may promote a chemical reaction between steel and cast aluminum alloys, leading to excellent bonding.
A comparison of dispersion compensating schemes in 40 Gb/s optical transmission with different modulation formats (2005)

The paper compares the effectiveness of four dispersion compensating schemes such as using dispersion compensating fiber (DCF), optical phase conjugator (OPC), OPC and distributed Raman amplifier (DRA) combination and apodized linearly chirped fiber Bragg grating (CFBG) in terms of the eye-opening penalty (EOP) at the end of the link. The comparison is also carried out with different modulation formats.
Step climbing motion planning for boarding-type mobility robot (2018)

In this paper, we propose a motion planning method for step climbing of a boarding-type mobility robot. We analyzed the mechanism of the boarding-type mobility robot. The climbing motion was split into three phases. We defined evaluation function as a linear combination of the cost functions. The next state of the robot was a state in which the value of the evaluation function is minimum. In this method, we used cost function to suppress seat tilt angle and power consumption in addition to mechanical limitations. We confirmed that boarding-type mobility robot was able to climb a step and seat tilt and power consumption were suppressed simultaneously.
Novel Lipoamino Acid- and Liposaccharide-Based System for Peptide Delivery:  Application for Oral Administration of Tumor-Selective Somatostatin Analogues (1999)

Lipoamino acid and liposaccharide conjugates of somatostatin analogue TT-232 were synthesized to modify the physicochemical properties of the parent peptide. The relative position, the number, and the nature of the lipid and/or saccharide moieties were varied. Experiments in vitro clearly showed that many compounds modified at the N- and/or C-terminus with lipid or sugar moieties retained the biological activity of the parent compound. An interesting construct was synthesized containing lipid and sugar units at opposite ends of the somatostatin analogue, so that the entire molecule could be considered as an amphipathic surfactant.