gebhart/patrepeval huggingface dataset:
Linear Encoding of Muscle Activity in Primary Motor Cortex and Cerebellum (2006)

The activity of neurons in primary motor cortex (M1) and cerebellum is known to correlate with extrinsic movement parameters, including hand position and velocity. Relatively few studies have addressed the encoding of intrinsic parameters, such as muscle activity. Here we applied a generalized regression analysis to describe the relationship of neurons in M1 and cerebellar dentate nucleus to electromyographic (EMG) activity from hand and forearm muscles, during performance of precision grip by macaque monkeys. We showed that cells in both M1 and dentate encode muscle activity in a linear fashion, and that EMG signals provide predictions of neural discharge that are equally accurate to those from kinematic information under these task conditions. Neural activity in M1 was significantly more correlated with both EMG and kinematic signals than was activity in dentate nucleus. Furthermore, the analysis enabled us to look at the temporal properties of muscle encoding. Cells were broadly tuned to muscle activity as a function of the lag between spiking and EMG and there was considerable heterogeneity in the optimal delay among individual neurons. However, a single lag (40 ms) was generally sufficient to provide good fits. Finally, incorporating spike history effects in our model offered no advantage in predicting novel spike trains, reinforcing the simple nature of the muscle encoding that we observed here.
Measurement of Coronary Blood Flow and Flow Reserve Using Magnetic Resonance Imaging (1997)

Coronary flow and CFR measurements using the MR techniques are feasible and are similar to those reported in the literature for healthy volunteers.
Photoelectric laser stimulation in a failure analysis laboratory (2004)

First photoelectric laser stimulation results (OBIC or LIVA) obtained with a laser scanning microscope which is a new version of the PHEMOS 1000 from Hamamatsu are presented. This technique is illustrated on ESD defect localization.
Abstract A23: SMYD3 links methylation of MAP3K2 to Ras-driven tumors (2015)

Abstract The Ras family of oncogenes is activated in a large fraction of human cancers. Treatment of Ras-driven tumors with inhibitors of protein kinases in the Ras signaling network, such as Raf or MEK is a promising therapeutic strategy. However, toxicity issues and the emergence of tumor cells that are resistant to these drugs underscore the need for a better understanding of the Ras pathway and for the development of novel therapeutic options to improve the survival of cancer patients. Deregulation in lysine methylation signaling has emerged as a common etiologic factor in cancer pathogenesis, with inhibitors of several histone lysine methyltransferases (KMTs) being developed as chemotherapeutics. The largely cytoplasmic KMT SMYD3 (SET and MYND domain containing protein 3) is overexpressed in numerous human tumors. However, the molecular mechanism by which SMYD3 regulates cancer pathways and its relationship to tumorigenesis in vivo are largely unknown. Here we show that methylation of MAP3K2 by SMYD3 increases MAP Kinase signaling and promotes the formation of Ras-driven carcinomas. Using mouse models for pancreatic ductal adenocarcinoma (PDAC) and lung adenocarcinoma (LAC), we found that abrogating SMYD3 catalytic activity inhibits tumor development in response to oncogenic Ras. We employed protein array technology to identify the MAP3K2 kinase as a target of SMYD3. In cancer cell lines, SMYD3-mediated methylation of MAP3K2 at lysine 260 potentiates activation of the Ras/Raf/MEK/ERK signaling module. Finally, the PP2A phosphatase complex, a key negative regulator of the MAP Kinase pathway, binds to MAP3K2 and this interaction is blocked by methylation. Together, our results elucidate a new role for lysine methylation in integrating cytoplasmic kinase-signaling cascades and establish a pivotal role for SMYD3 in the regulation of oncogenic Ras signaling. Citation Format: Pawel K. Mazur, Nicolas Reynoird, Purvesh Khatri, Atul J. Butte, Alex Wilkinson, Benjamin Garcia, Shichong Liu, Michiel Vermeulen, Pascal W.T.C. Jansen, Peter J. Tummino, Ryan G. Kruger, Glenn S. Van Aller, Olena Barbash, Michael Huddleston, Or Gozani, Julien Sage. SMYD3 links methylation of MAP3K2 to Ras-driven tumors. [abstract]. In: Proceedings of the AACR Special Conference on Pancreatic Cancer: Innovations in Research and Treatment; May 18-21, 2014; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2015;75(13 Suppl):Abstract nr A23.
Melt Conveying in Single-Screw Extruders: Modeling and Simulation (2022)

Numerous analyses have modeled the flow of polymer melts in the melt-conveying zones of single-screw extruders. While initial studies mainly provided exact analytical results for combined drag and pressure flows of Newtonian fluids, more recently developed, numerical methods seek to deepen the understanding of more realistic flow situations that include shear-thinning and non-isothermal effects. With the advent of more powerful computers, considerable progress has been made in the modeling and simulation of polymer melt flows in single-screw extruders. This work reviews the historical developments from a methodological point of view, including (1) exact analytical, (2) numerical, and (3) approximate methods. Special attention is paid to the mathematical models used in each case, including both governing flow equations and boundary conditions. In addition, the literature on leakage flow and curved-channel systems is revisited.
Longevity Expectations for Polymers in Medical Devices Demand New Approaches to Evaluating Their Biostability (2020)

Ten years after a new poly(dimethylsiloxane)urethane material was introduced as part of a long-term medical device implant, an unexpectedly high rate of in-service degradation was observed. The chemical signatures of molecular degradation in the materials were not identified during the comparatively short preclinical assessment of biostability. This outcome highlights the need to transform the assessment of biostability for new materials used in long-term implanted medical devices to protocols that rely more heavily on accelerated in vitro testing. The industry has over-relied on in vivo exposure to assess the stability of a material due to the perceived complexities associated with the accurate simulation of the biological environment. Strategically designed accelerated in vitro testing can provide important insights into the long-term biostability of materials: insights that cannot be readily gleaned through the in vivo studies that dominate current regulatory guidelines. Real-time validation of previously published accelerated data combined with clinical observations substantiates the accelerated approach and creates a compelling case for shifting the emphases in biostability assessment, especially for devices that have anticipated lifespans that exceed a decade.
Behavior of /sup 111/In-labeled F(ab')/sub 2/ fragments (19-9) in patients (1984)

The authors have evaluated the in vivo kinetics, biodistribution and tumor localization properties of radiolabeled monoclonal F(ab')/sub 2/ 19-9 antibody against a tumor-associated antigen. Nine patients with known sites of tumor recurrences were studied to up to 72 hours and blood and urine collected. Organ uptake was measured using the geometric mean to two views with attenuation correction and serial whole body scans to evaluate clearance. Labeling was achieved by adding 1-2 mCi of /sup 111/In acetate to a sterile, pyrogen-free vial containing 1 mg of antibody previously coupled with DPTA using the cyclic anhydride; the injectates were radiochemically pure without post-labeling purification. Following injection, blood activity levels decreased rapidly but whole body clearance was slow (T/sub 1/2/ about 200 hrs.) with losses to urine predominating (mean value 0.4%/hr.). Organ accumulation was greatest in liver (mean value 17%) and was constant throughout each study. Kidney and spleen values peaked at approximately 7% and 2% respectively with only slight uptake in bone marrow. Affinity chromatographic analysis of serum samples showed insignificant transcomplexation of label to transferrin. HPLC analysis of serum and urine samples showed that circulating activity is predominantly protein-bound and that occasionally activity is also present in a low-molecular weightmore » form indistinguishable with a similar species always present in urine. The authors conclude that the /sup 111/In-labeled fragments remain stabily labeled in vivo and provide good diagnostic images. High and persistent liver and kidney levels, which may in part reflect antibody catabolism, is a limiting factor.« less
Preliminary design of a set of four beamlines for the DLSR upgrade of the advanced light source (2020)

Author(s): Wojdyla, Antoine; Alvarez, Henry P; Bergeret, Maxime; Sheng, Albert; Bryant, Diane; Allezy, Arnaud P; Cutler, Grand D; Yashchuk, Valeriy V; MacDowell, Alastair A; Goldberg, Kenneth A; Sanchez del Rio, Manuel; Morton, Simon A; DiMasi, Elaine; Padmore, Howard A | Editor(s): Sawhney, Kawal; Chubar, Oleg
Harmonic Reduction Method Using Minor Sampling Process for Sensorless Signal Injection-Based Position Control Technique (2023)

This paper proposes a Fourier series expansion-based sensorless position control method for permanent magnet synchronous motors (PMSMs). More specifically, a minor sampling process that is shorter than the vector control period is introduced to reduce the amount of signal injection. The effectiveness of this method is demonstrated via simulatively and experimentally to show that the amount of signal injection can be reduced using the proposed method.
Transformation of vegetative cells of Bacillus anthracis with plasmid DNA (1990)

Methods have been developed for chemical transformation and electro-transformation (electroporation) of vegetative cells of Bacillus anthracis with supercoiled plasmid DNA. Chemical transformation was dependent on incubation in Tris/HCl with osmotic support and transformation with plasmid DNA was effected by treatment with polyethylene glycol 3350. Maximum transformation frequencies were 3.8 x 10(-5) transformant c.f.u. per viable c.f.u. (1 x 10(3) c.f.u. per micrograms DNA). Optimal frequencies were pH dependent and were affected by growth-medium composition. Transformation was not observed with linear or multimeric plasmid DNA. Electro-transformation of B. anthracis using high field intensity electroporation was dependent on the composition of both the growth medium and the electroporation buffer. Maximum electro-transformation frequencies were 5.3 x 10(-4) c.f.u. per viable c.f.u. (2.6 x 10(4) c.f.u. per micrograms DNA). The use of early exponential phase cells was critical to both procedures and the maximum efficiency (c.f.u. per micrograms DNA) of each system was strain dependent under the conditions described.
Glibenclamide Stimulates and Glucose Inhibits Glucagon Release Induced by Calcium Deprivation (1984)

The effects of low extracellular calcium levels on glibenclamide- and glucose-induced A-, B-, and D-cell secretion were investigated using the perfused pancreas preparation of the rat. At normal (2.6 mM) calcium, glucagon secretion was unaffected by glibenclamide (1 microgram/ml) and transiently suppressed by glucose (6.7 and 16.7 mM). Reduction of extracellular calcium to 0.24 mM promptly and persistently enhanced glucagon secretion in the presence of 3.3 mM glucose; this effect of low calcium was, however, diminished (P less than 0.001) by 54% and 61% when the glucose concentration was increased to 6.7 and 16.7 mM, respectively. In contrast, glibenclamide enhanced the glucagon response to calcium reduction, a twofold stimulation by the drug being observed at all glucose concentrations. Reduction of calcium to 0.24 mM failed to inhibit first-phase glibenclamide or glucose-induced insulin release; second phase was, however, inhibited whether induced by glibenclamide (in the presence of 6.7 mM glucose) or by glucose 16.7 mM per se. Reduction of calcium uniformly and completely abolished glibenclamide and glucose-induced somatostatin responses. It is concluded that: (1) the glucagon response induced by calcium deprivation is inhibited by glucose but potentiated by glibenclamide, and (2) reversal of a D-cell paracrine effect could underlie the glibenclamide effect.
25 Years after HIV Discovery: Prospects for Cure and Vaccine (Nobel Lecture) (2009)

Viruses are the uniting theme of the 2008 Nobel Prize for Physiology or Medicine. Françoise Barré-Sinoussi and Luc Montagnier received their Prize for the discovery of the human immunodeficiency virus (HIV), and Harald zur Hausen identified that cervical cancer is triggered by papillomaviruses. The Nobel Laureates describe their research first-hand.
Dihydroquinidine Acetate (2009)

(R = Ac) [72989-10-7] C22H28N2O3 (MW 368.47) InChI = 1/C22H28N2O3/c1-4-15-13-24-10-8-16(15)11-21(24)22(27-14(2)25)18-7-9-23-20-6-5-17(26-3)12-19(18)20/h5-7,9,12,15-16,21-22H,4,8,10-11,13H2,1-3H3/t15-,16-,21+,22-/m0/s1 InChIKey = ZVEDOOXEZTUEBN-FRMGNDQPBF (R = p-ClC6H4C(O)) [113162-02-0] C27H29ClN2O3 (MW 464.99) InChI = 1/C27H29ClN2O3/c1-3-17-16-30-13-11-19(17)14-25(30)26(33-27(31)18-4-6-20(28)7-5-18)22-10-12-29-24-9-8-21(32-2)15-23(22)24/h4-10,12,15,17,19,25-26H,3,11,13-14,16H2,1-2H3/t17-,19-,25+,26-/m0/s1 InChIKey = TXVNNFDXQZFMBQ-PRUVNFMMBY (R = H) [1435-55-8] C20H26N2O2 (MW 326.44) InChI = 1/C20H26N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h4-6,8,11,13-14,19-20,23H,3,7,9-10,12H2,1-2H3/t13-,14-,19+,20-/m0/s1 InChIKey = LJOQGZACKSYWCH-LHHVKLHABI (asymmetric dihydroxylation;2 conjugate additions;3 carbonyl additions3) Alternate Name: DHQD-Ac. Physical Data: p-ClC6H4C(O): mp 102–105 °C; [α]D −73° (c = 1, EtOH). Solubility: p-ClC6H4C(O): sol CH2Cl2, Et2O, EtOH, EtOAc. Form Supplied in: the p-chlorobenzoate is available as a white foam. Preparative Methods: the acetate is prepared from dihydroquinidine4 and the p-chlorobenzoate is commercially available. The phthalazine-derived bis(dihydroquinidine) ligand is commercially available.5 A formulation of the standard reactants for the asymmetric dihydroxylation (AD-mix-β) on the small scale has been developed and is commercially available.6 AD-mix-β (1 kg) consists of potassium osmate (0.52 g), the phthalazine-derived ligand (5.52 g), K3Fe(CN)6 (700 g), and powdered K2CO3 (294 g). Purification: the recovery of dihydroquinidine p-chlorobenzoate after a dihydroxylation reaction is accomplished in the following manner:7 the crude dihydroquinidine p-chlorobenzoate (DHQD-CLB) is dissolved in ether, cooled to 0 °C, and HCl gas is bubbled into the solution until a pH of 1–2 is obtained using wet pH paper. The pale yellow precipitate of the hydrochloride salt is collected by filtration and dried under high vacuum (0.01 mmHg). The free base is liberated by suspending the salt in EtOAc, cooling the heterogeneous mixture to 0 °C, and adding 28% NH4OH (or 15% NaOH) until a pH = 11 is obtained. After separation, the aqueous layer is extracted with portions of EtOAc, the combined organic layers are dried over Na2SO4, and the solvent removed in vacuo to give the pure DHQD-CLB as a white foam. Handling, Storage, and Precautions: toxic; use in a fume hood.
Structural studies of zirconium alkylphosphonate monolayers and multilayer assemblies (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructural studies of zirconium alkylphosphonate monolayers and multilayer assembliesM. L. Schilling, H. E. Katz, S. M. Stein, S. F. Shane, W. L. Wilson, S. B. Ungashe, G. N. Taylor, T. M. Putvinski, C. E. D. Chidsey, and S. BurattoCite this: Langmuir 1993, 9, 8, 2156–2160Publication Date (Print):August 1, 1993Publication History Published online1 May 2002Published inissue 1 August 1993https://pubs.acs.org/doi/10.1021/la00032a042https://doi.org/10.1021/la00032a042research-articleACS PublicationsRequest reuse permissionsArticle Views263Altmetric-Citations55LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Novel DDR process and materials for front-edge NTD process (2016)

We developed the novel process and material which can prevent the pattern collapse issue perfectly. The process was Dry Development Rinse (DDR) process, and the material used in this process was DDR Material (DDRM). DDRM was containing siloxane polymer which could be replaced the space area of the photo resist pattern. And finally, the reversed pattern would be created by dry etching process without any pattern collapse issue. This novel process was useful not only in positive tone development (PTD) process but also in negative tone development (NTD) process. We newly developed DDRM for NTD process. Novel DDRM consist of special polymer and it used organic solvent system. So, new DDRM showed no mixing property with NTD photo resist and it has enough etch selectivity against NTD photo resist. Image reversal was successfully achieved by combination of NTD process and DDR process keeping good pattern quality. Tone reverse pattern below hp 18nm was obtained without any pattern collapse issue, which couldn’t be created by just using normal NTD process.
Analgesics, Centrally Acting (2011)

Abstract The article contains sections titled: 1. Opioids 1.1. Opioids in Clinical Use 1.1.1. Morphine and Morphinane Derivatives 1.1.2. Piperidine Derivatives 1.1.3. Fentanyl and Congeners 1.1.4. Methadone and Congeners 1.2. Other Structures 1.2.1. Mixed Opioid Agonist‐Antagonists and Partial Agonists 1.2.2. Opioid Antagonists 2. Anti‐Neuropathic Analgesics and Other Nonopioid Compounds 2.1. Neuropathic Pain Treatment 2.2. Individual Compounds
Method for Determining Instantaneous Temperature at the Surface of Combustion Chamber Deposits in an HCCI Engine (2013)

Homogeneous charge compression ignition (HCCI) combustion is widely regarded as an attractive option for future high efficiency gasoline engines. HCCI combustion permits operation with a highly dilute, well mixed charge, resulting in high thermal efficiency and extremely low NOx and soot emissions, two qualities essential for future propulsion system solutions. Because HCCI is a thermokinetically dominated process, full understanding of how combustion chamber boundary thermal conditions affect the combustion process are crucial. This includes the dynamics of the effective chamber wall surface temperature, as dictated by the formation of combustion chamber deposits (CCD). It has been demonstrated that, due to the combination of CCD thermal properties and the sensitivity of HCCI to wall temperature, the phasing of autoignition can vary significantly as CCD coverage in the chamber increases. In order to better characterize and quantify the influence of CCDs, a numerical methodology has been developed which permits calculation of the crank-angle resolved local temperature profile at the surface of a layer of combustion chamber deposits. This unique predictor-corrector methodology relies on experimental measurement of instantaneous temperature underneath the layer, i.e., at the metal-CCD interface, and known deposit layer thickness. A numerical method for validation of these calculations has also been devised. The resultant crank-angle resolved CCD surface temperature and heat flux profiles both on top and under the CCD layer provide valuable insight into the near wall phenomena, and shed light on the interplay between the dynamics of the heat transfer process and HCCI burn rates.
Applications of scanning near-field photon emission microscopy (2009)

In this paper, the application of scanning near-field photon emission microscopy for imaging photon emission sites is demonstrated. Photon emissions generated by a Fin-FET test structure with one metallization layer are imaged with spatial resolution of 50 nm using scattering dialectic probe. The potential applications and limitations of the technique are discussed.
Impact of Amplifier Noise Figure on Network Throughput (2016)

The impact of the amplifier noise figure (NF) on the optical network throughput is quantified from an information viewpoint. For every dB of NF decrease, throughput gains between 4% and 7% are reported.
Wavefield signal apparition: Simultaneous source separation (2016)

A new method for discrete sampling of signals with applications to separation of interfering wavefields is presented. By utilizing a periodic sequence of source signatures along one source line, that wavefield becomes separately partially visible in the spectral domain where it can be isolated from interfering signals, processed, and subtracted from the original recordings, thereby separating the wavefields from each other. The concept is referred to as signal apparition which we suggest refers to "the act of becoming visible". We anticipate a broad range of applications of the new sampling approach. In this abstract we discuss the application of seismic apparition to simultaneous source acquisition to increase productivity and/or obtain a better source-side sampling of seismic data. Presentation Date: Wednesday, October 19, 2016 Start Time: 10:20:00 AM Location: 163/165 Presentation Type: ORAL
Dynamic characterization of MEMS-tunable vertical-cavity SOAs (2006)

We analyze the dynamics of tunable-VCSOAs. At 6 mT the devices exhibit a Q of ~500 and an f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> of 168.32 kHz. At atmosphere Q is reduced to 1.2 resulting in <10 mus switching times
Advances in AlGaInN laser diode technology (2014)

The latest developments in AlGaInN laser diode technology are reviewed. The AlGaInN material system allows for laser diodes to be fabricated over a very wide range of wavelengths from u.v., i.e, 380nm, to the visible, i.e., 530nm, by tuning the indium content of the laser GaInN quantum well. Advantages of using Plasma assisted MBE (PAMBE) compared to more conventional MOCVD epitaxy to grow AlGaInN laser structures are highlighted. Ridge waveguide laser diode structures are fabricated to achieve single mode operation with optical powers of &gt;100mW in the 400-420nm wavelength range that are suitable for telecom applications. Visible light communications at high frequency (up to 2.5 Gbit/s) using a directly modulated 422nm Galliumnitride (GaN) blue laser diode is reported. High power operation of AlGaInN laser diodes is demonstrated with a single chip, AlGaInN laser diode ‘mini-array’ with a common p-contact configuration at powers up to 2.5W cw at 410nm. Low defectivity and highly uniform GaN substrates allow arrays and bars of nitride lasers to be fabricated. GaN laser bars of up to 5mm with 20 emitters, mounted in a CS mount package, give optical powers up to 4W cw at ~410nm with a common contact configuration. An alternative package configuration for AlGaInN laser arrays allows for each individual laser to be individually addressable allowing complex free-space and/or fibre optic system integration within a very small form-factor.