gebhart/patrepeval huggingface dataset:
Clinical diagnostic criteria for premenstrual syndrome and guidelines for their quantification for research studies (2007)

Premenstrual syndrome (PMS) encompasses a variety of symptoms appearing during the luteal phase of the menstrual cycle. Although PMS is widely recognized, the etiology remains unclear and it lacks definitive, universally accepted diagnostic criteria. To address these issues an international multidisciplinary group of experts evaluated the current definitions and diagnostic criteria of PMS and premenstrual dysphoric disorder (PMDD). Following extensive correspondence, a consensus meeting was held with the aim of producing updated diagnostic criteria for PMS and guidelines for clinical and research applications. This report presents the conclusions and recommendations of the group. It is hoped that the criteria proposed by the group will become widely accepted and eventually be incorporated into the next edition of the World Health Organization's International Classification of Diseases (ICD-11). It is also hoped that the proposed guidelines for quantification of criteria will be used by clinicians and investigators to facilitate diagnostic uniformity in the field as well as adequate treatment modalities when warranted.
Glenosphere Disengagement (2008)

Level III, retrospective study. See the Guidelines for Authors for a complete description of levels of evidence.
Development of a mismatch amplification mutation assay to correctly serotype isolates of Streptococcus suis serotypes 1, 2, 1/2, and 14 (2020)

<i>Streptococcus suis</i> is one of the most important bacterial swine pathogens worldwide and is an emerging pathogen in humans. There are 29 serotypes, and serotyping, which is based on the antigenicity of the capsular polysaccharide (CPS) or on its coding genes, is often part of routine identification and provides further information regarding <i>S. suis</i> virulence and zoonotic potential. Serotypes 2 and 14 possess high zoonotic potential, and serotype 1/2 is the serotype most frequently isolated from diseased pigs in North America. PCR has replaced antibody-based techniques to perform serotyping. However, traditional PCR is not able to differentiate serotype 2 from 1/2 and serotype 1 from 14, given that the only difference in the <i>cps</i> loci of those serotype pairs is a nonsynonymous single-nucleotide polymorphism. We developed a mismatch amplification mutation assay (MAMA)-PCR that was able to correctly serotype 148 isolates previously known to be serotypes 1, 2, 1/2, or 14. This technique will be highly useful in animal and human health laboratories performing PCR serotyping of <i>S. suis</i> isolates.
Recurrence of puerperal psychosis in both pre and post-partum periods: a case report. (2002)

A case of recurrent pre and postpartum psychosis is described. Pre-partum psychosis was more severe in intensity when compared with postpartum psychosis and, if untreated, it may have continued as postpartum psychosis. Presence of bipolar affective illness in the family, ongoing stressor and unplanned pregnancy may be the risk factors for developing pregnancy- related psychosis. This case report also adds weight to the proposition that puerperal psychosis might occur in late pregnancy also.
Haemophagocytosis in bone marrow rhabdomyosarcoma (1999)

Acute leukaemia was suspected in a 22-year-old female and a bone marrow aspirate was sent to us for diagnostic purposes. Immunophenotyping revealed absence of haemopoietic antigens but positivity for desmin, indicating a rhabdomyosarcoma. Subsequently, this diagnosis was confirmed by a chest-wall biopsy and detection of a rhabdomyosarcoma-specific t(2;13). Tumour cells containing erythrocytes (white arrows), as well as nucleated cells (probably lymphocytes, black arrows), were visible in MGG (A) and in anti-desmin APAAP (B) stained smears. As haemophagocytosis has very rarely been observed in patients with rhabdomyosarcoma or other solid tumours, although it has been seen in a variety of haemopoietic malignancies, immunophenotyping may enable a rapid and reliable diagnosis.
Optimal Control Design for Operating a Hybrid PV Plant with Robust Power Reserves for Fast Frequency Regulation Services (2022)

This paper presents an optimal control strategy for operating a solar hybrid system consisting of solar photovoltaic (PV) and a high-power, low-storage battery energy storage system (BESS). A state-space model of the hybrid PV plant is first derived, based on which an adaptive model predictive controller is designed. The controller's objective is to control the PV and BESS to follow power setpoints sent to the the hybrid system while maintaining desired power reserves and meeting system operational constraints. Furthermore, an extended Kalman filter (EKF) is implemented for estimating the battery SOC, and an error sensitivity is executed to assess its limitations. To validate the proposed strategy, detailed EMT models of the hybrid system are developed so that losses and control limits can be quantified accurately. Day-long simulations are performed in an OPAL-RT real-time simulator using second-by-second actual PV farm data as inputs. Results verify that the proposed method can follow power setpoints while maintaining power reserves in days of high irradiance intermittency even with a small BESS storage.
Sustainable energy from paper industry wastes (2013)

Secondary fibre paper mills are significant users of both heat and electricity which is mainly derived from the combustion of fossil fuels. The cost of producing this energy is increasing year upon year. These mills are also significant producers of fibrous sludge and reject waste material which can contain high amounts of useful energy. Currently the majority of these waste fractions are disposed of by landfill, land-spread or incineration using natural gas. These disposal methods not only present environmental problems but are also very costly. The focus of this work was to utilise the waste fractions produced at secondary fibre paper mills for the on-site production of combined heat and power (CHP) using advanced thermal conversion methods (gasification and pyrolysis), well suited to relatively small scales of throughput. The heat and power can either be used on-site or exported. The first stage of the work was the development of methods to condition selected paper industry wastes to enable thermal conversion. This stage required detailed characterisation of the waste streams in terms of proximate and ultimate analysis and heat content. Suitable methods to dry and condition the wastes in preparation for thermal conversion were also explored. Through trials at pilot scale with both fixed bed downdraft gasification and intermediate pyrolysis systems, the energy recovered from selected wastes and waste blends in the form of product gas and pyrolysis products was quantified. The optimal process routes were selected based on the experimental results, and implementation studies were carried out at the selected candidate mills. The studies consider the pre-processing of the wastes, thermal conversion, and full integration of the energy products. The final stage of work was an economic analysis to quantify economic gain, return on investment and environmental benefits from the proposed processes.
Comprehensive Molecular Characterization of Malignant and Microenvironmental Cells in Waldenstrom’s Macroglobulinemia by Gene Expression Profiling. (2007)

Abstract Waldenstrom’s Macroglobulinemia (WM) is an incurable B-cell malignancy characterized by bone marrow (BM) infiltration with a spectrum of clonally related cells, including small lymphocytes and lymphoplasmacytic cells (CD19+) as well as mature plasma cells (CD138+). The molecular pathogenesis of the disease remains to be defined. We therefore analyzed the gene expression profiles of CD19+ and CD138+ BM mononuclear cells from 30 untreated patients with WM and compared their gene expression profile to their normal counterparts from 10 healthy donors using Affymetrix microarrays (U133 plus 2.0). Since the microenvironment plays an important role in the pathogenesis of WM, we also profiled and compared gene expression profiling for CD19 and CD138 depleted BM mononuclear cells from the same patients and healthy donors. Gene expression analysis was performed using dChip software. Unsupervised hierarchical cluster analysis demonstrated distinct gene expression patterns between WM cells versus their normal counterparts. In supervised hierarchical cluster analysis selecting for genes with &gt; 2 fold change in expression and a False discovery Rate (FDR) &lt; 2%, a set of 1171, 582 and 360 genes were found to be differentially expressed between WM patient and healthy donor CD19+, CD138+, as well as CD19/CD138 depleted (microenvironmental) cells, respectively. Among the most significantly over-expressed genes in the CD19+ compartment in WM patients were: BCL2, TNFRSF13B, TNFRSF17, IGLL1, CCR2, CLLU1, whilst the AP1 family genes JUND and FOSB were among the most significantly down-regulated genes in both CD19+ and CD138+ cells in WM patients. Other interesting transcripts which were over-expressed in CD138+ cells from WM patients included those from genes involved in transcription regulation (ZKSCAN1, ZMYM1, ZNF189, ZNF19, and ZNF559) and interferon response (IFI16 and IFIH1). Of considerable interest was our observation that microenvironmental cells in WM patients demonstrated an overactive transcriptional profile composed of genes which are associated with immune and inflammatory responses including the Toll like receptors (TLR 1,5,7,8), interferon and cytokines (IFI16, IFNAR1, IL-10R, IL-8R), genes encoding extracellular matrix components (Fibronectin and Hepatocyte Growth Factor) as well as genes involved in apoptotic signaling (TNFSF10, TRAF4). These studies provide the first comprehensive molecular characterization of WM, dissecting the molecular features of the two immunophenotypically distinct populations of malignant cells, and providing for the first time evidence for a distinct molecular profile in BM microenviromental cells.
Application of analytical electron microscopy to diffusivity measurement requiring X-ray absorption correction (1990)

Abstract X-ray microanalysis using an analytical electron microscope is applied to diffusivity measurements in an alloy system where the X-ray absorption correction is imperative. It is shown that the differential X-ray absorption (DXA) method is useful for the absorption correction in the determination of a concentration gradient across a diffusion couple interface.
Chemical Recognition in Cell-Imprinted Polymers (2012)

A glass slide covered with bacteria is pressed into another glass slide coated with partially cured polydimethylsiloxane (PDMS). The PDMS is hardened and the cells are removed to create a textured surface whose indentations preferentially capture the same type of bacteria when a mixture of bacteria is flowed over it. Overcoating the cell-imprinted PDMS with methylsilane groups causes the resulting surface to lose much of its ability to preferentially capture the imprinted bacteria, although the shapes of the imprints, measured by atomic force field microscopy, are shown to be hardly affected. We interpret this behavior as strong evidence that chemical recognition plays a dominant role in cell sorting with cell-imprinted PDMS polymer films.
Bulk Periodically Poled MgO-doped LiNbO3 by External Electric Field Application (1999)

Bulk periodically poled MgO-doped LiNbO 3 (PPMgLN) crystals have been successfully fabricated by an electric field poling process using a liquid electrode technique. The fabricated PPMgLN crystals with a 30.0 µm domain-inverted period were 0.5 mm thick and had uniform domain structures more than 30 mm long. The ratio of the domain-inverted width to the domain-inverted period (duty cycle) for fabricated PPMgLN was approximately 50% on average. Furthermore, using the same method, 0.5-mm-thick PPMgLN with a 17.6 µm domain-inverted period and more than 30 mm interaction length could be fabricated and the average duty cycle was confirmed to be approximately 50%.
Fabrication of an Interdigitated Array Electrode on ZnSe and Its Application to Electrooptical Measurements Using FT-IR Spectroscopy (2000)

An interdigitated array electrode (IDA) is fabricated on an IR-transparent substrate for use in electrooptical measurements using Fourier transform infrared (FT-IR) spectroscopy. The fabrication of the IDA and its unique sampling geometry for transmission spectroscopy is detailed. The gold IDA was patterned on the ZnSe substrate using a photolithographically defined liftoff process. An IR flow cell was modified to enable the substrate containing the IDA to be used for electrooptical measurements in transmission. The utility of the electrooptical cell is demonstrated by application to two model systems. In the first, changes in the conductivity and spectral features of a receptor membrane (Nafion) upon dehydration are measured. In the second, the measurement of the electric-field-induced orientation of a liquid-crystalline film of 4-n-pentyl-4'-cyanobiphenyl was conducted in a new experimental geometry, with IR transmission normal to the direction of the applied electric field. Difference spectroscopy facilitated the observation of the change in orientation of the liquid crystal with applied potential. These systems demonstrate the general utility of the fabrication scheme described here. It also illustrates its facile adaptation to infrared difference spectroscopy as a means of studying complex phenomena in electrochemical and electrooptical systems.
Personalized Disease Prevention (PDP): study protocol for a cluster-randomized clinical trial (2022)

ClinicalTrials.gov NCT05463887. Registered on July 19, 2022.
Impact of Coronary Atherosclerosis on Bioresorbable Vascular Scaffold Resorption and Vessel Wall Integration (2020)

The integration of the Absorb bioresorbable vascular scaffold (BVS) into the arterial wall has never been tested in an in vivo model of atherosclerosis. This study aimed to compare the long-term (up to 4 years) vascular healing responses of BVS to an everolimus-eluting metallic stent in the familial hypercholesterolemic swine model of atherosclerosis. The multimodality imaging and histology approaches indicate that the resorption and vascular integration profile of BVS is not affected by the presence of atherosclerosis. BVS demonstrated comparable long-term vascular healing and anti-restenotic efficacy to everolimus-eluting metallic stent but resulted in lower late lumen loss at 4 years.
Adsorption, desorption, and surface diffusion kinetics of NH3 on MgO(100) (1991)

Laser-induced thermal desorption (LITD) techniques were used to study the adsorption, desorption, and surface diffusion kinetics of NH3 on MgO(100) single-crystal surfaces. Isothermal LITD adsorption measurements revealed that the sticking coefficient of NH3 on MgO(100) was constant vs coverage and decreased with increasing surface temperature. The adsorption kinetics were consistent with a mobile precursor intermediate. In addition, the saturation NH3 coverage on MgO(100) was strongly dependent on temperature, and decreased by a factor of 5 as temperature increased from 130 to 165 K. Isothermal and linear temperature ramp LITD experiments indicated that the desorption kinetics of NH3 from MgO(100) could be modeled using a first-order rate law with a coverage-dependent desorption activation energy. The coverage dependence of the desorption activation energy was consistent with repulsive lateral interactions between NH3 adsorbates on the MgO(100) surface. The surface diffusion of NH3 on MgO(100) was also examined using LITD techniques. In contrast to recent predictions of NH3 surface diffusion on MgO(100), no evidence of NH3 surface mobility (D≤10−9 cm2/s) was observed for temperatures as high as 165 K.
Projecting the burden of diabetes in Australia – what is the size of the matter? (2009)

Despite variation in assumptions and methodology used, all the published predictions demonstrate that diabetes is an escalating problem for Australia. We can safely assume that unless trends in diabetes incidence are reversed there will be at least 2 million Australian adults with diabetes by 2025. If obesity and diabetes incidence trends, continue upwards, and mortality continues to decline, up to 3 million people will have diabetes by 2025, with the figure closer to 3.5 million by 2033. The impact of this for Australia has not been measured.
Single Polarization Direct Detection Optical OFDM with 100 Gb/s Throughput: A Concept Taking into Account Higher Order Modulation Formats (2010)

Several strategies to achieve 100 Gb/s throughput for single polarization DD-OFDM are considered. Based on state-of-the-art in converter technology, using higher order modulation formats a concept aiming at high sensitivity is proposed.
The structural role of bacterial eDNA in the formation of biofilm streamers (2021)

Abstract Across diverse habitats, bacteria are mainly found as biofilms, surface-attached communities embedded in a self-secreted matrix of extracellular polymeric substances (EPS), which enhances bacterial resistance to antimicrobial treatment and mechanical stresses. In the presence of flow and geometric constraints such as corners or constrictions, biofilms take the form of long, suspended threads known as streamers, which bear important consequences in industrial and clinical settings by causing clogging and fouling. The formation of streamers is thought to be driven by the viscoelastic nature of the biofilm matrix. Yet, little is known about the structural composition of streamers and how it affects their mechanical properties. Here, using a microfluidic platform that allows growing and precisely examining biofilm streamers, we show that extracellular DNA (eDNA) constitutes the backbone and is essential for the mechanical stability of Pseudomonas aeruginosa ’ s streamers. This finding is supported by the observations that DNA-degrading enzymes prevent the formation of streamers and clear already formed ones, and that the antibiotic ciprofloxacin promotes their formation by increasing the release of eDNA. Furthermore, using mutants for production of the exopolysaccharide Pel, an important component of P. aeruginosa ’ s EPS, we reveal a new, although indirect role of Pel, in tuning the mechanical properties of the streamers. Taken together, these results highlight the importance of eDNA and of its interplay with Pel in determining the mechanical properties of P. aeruginosa streamers, and suggest that targeting the composition of streamers can be an effective approach to control the formation of these biofilm structures.
Demonstration of a semipolar (10(1)over-bar(3)over-bar) InGaN/GaN green light emitting diode - eScholarship (2005)

We demonstrate the growth and fabrication of a semipolar (10 (13) over bar) InGaN/GaN green (similar to 525 nm) light emitting diode (LED). The fabricated devices demonstrated a low turn-on voltage of 3.2 V and a series resistance of 14.3 Omega. Electroluminescence measurements on the semipolar LED yielded a reduced blueshifting of the peak emission wavelength with increasing drive current, compared to a reference commercial c-plane LED. On-wafer measurements yielded an approximately linear increase in output power with drive current, with measured values of 19.3 and 264 muW at drive currents of 20 and 250 mA,respectively. The external quantum efficiency did not decrease appreciably at high currents. Polarization anisotropy was also observed in the electroluminescence from the semipolar green LED, with the strongest emission intensity parallel to the [1 (2) over bar 10] direction. A polarization ratio of 0.32 was obtained at a drive current of 20 mA. (c) 2005 American Institute of Physics.
Second-generation 193-nm bottom antireflective coatings (BARCs) (2000)

Two organic, spin-on BARCs are in the small scale manufacturing phase -- with the goal being a 193-nm product optimized for commercialization. Chemistries of the BARCs are shown in this paper and performance of the two products relative to industry accepted needs is discussed. The thermoset BARCs, EXP98090B and EXP99001D, are prepared from hydroxy-functional, dye-attached acrylic polymers by adding an aminoplast and sulfonic acid catalyst. With select 193-nm resists, the BARCs give resolution of L/S pairs down to 0.12 micrometer. Plasma etch rates of both BARCs are comparable to those of 193-nm photoresists. Other BARC performance parameters that are discussed for the two products include: film and optical properties, conformality, simulated reflectance curves, spin-bowl compatibility, metals content, and defects.
The effect of electric-field-induced alignment on the electrical mobility of fractal aggregates (2018)

We study the effects of electric field strength on the mobility of soot-like fractal aggregates (fractal dimension of 1.78). The probability distribution for the particle orientation is governed by the ratio of the interaction energy between the electric field and the induced dipole in the particle to the energy associated with Brownian forces in the surrounding medium. We use our extended Kirkwood–Riseman method to calculate the friction tensor for aggregates of up to 2000 spheres, with primary sphere sizes in the transition and near-free molecule regimes. Our results for electrical mobility versus field strength are in good agreement with published experimental data for soot, which show an increase in mobility on the order of 8% from random to aligned orientations. Our calculations show that particles become aligned at decreasing field strength as particle size increases because particle polarizability increases with volume. Large aggregates are at least partially aligned at field strengths below 1000 V/cm, though a small change in mobility means that alignment is not an issue in many practical applications. However, improved differential mobility analyzers would be required to take advantage of small changes in mobility to provide shape characterization.Copyright © 2018 American Association for Aerosol Research
Design issues in heterogeneous 3D/2.5D integration (2013)

Efficient processing of fine-pitched Through Silicon Vias, micro-bumps and back-side re-distribution layers enable face-to-back or face-to-face integration of heterogeneous ICs using 3D stacking and/or Silicon Interposers. While these technology features are extremely compelling, they considerably stress the existing design practices and EDA tool flows typically conceived for 2D systems. With all system, technology and implementation level options brought with these features, the design space increases to an extent where traditional 2D tools cannot be used any more for efficient exploration. Therefore, the cost-effective design of future 3D ICs products will require new planning and co-optimisation techniques and tools that are fast and accurate enough to cope with these challenges. In this paper we present design methodology and the practical EDA tool chain that covers different aspects of the design flow and is specific to efficient design of 3D-ICs. Flow features include: fast synthesis and 3D design partitioning at gate level, TSV/micro-bump array planning, 3D floor planning, placement and routing, congestion analysis, fast thermal and mechanical modeling, easy technology vs. implementation trade-off analysis, 3D device models generations and Design-for-Test (DfT). The application of the tool chain is illustrated using concrete example of a real-world design, showing not only the applicability of the tool chain, but also the benefits of heterogeneous 2.5 and 3D integration technologies.