gebhart/patrepeval huggingface dataset:
Clinical statistics of gynecologic cancers in Japan (2017)

Cervical, endometrial, and ovarian cancers, have both high morbidity and mortality among the gynecologic malignant tumors in Japan. The present study was conducted using both the population-based cancer registry and the gynecologic cancer registry to elucidate the characteristics of gynecologic malignant tumors in Japan. Based on nationwide estimates from the population-based cancer registry in Japan, the morbidities and mortality of cervical, endometrial, and ovarian cancers were obtained and used for analysis. Clinicopathologic factors for cervical cancer, endometrial cancer, ovarian cancer, including age, clinical stage, postsurgical stage, histological type, therapeutic strategy, and prognosis were retrieved from the gynecologic cancer registry published by the Japan Society of Obstetrics and Gynecology and used for analysis. The morbidities of cervical, endometrial, and ovarian cancers were 10,908, 13,606, and 9,384 women in 2012, respectively. The prevalence of endometrial cancer has significantly and consistently been increasing and represents the most common gynecologic malignant tumor in Japan. The mortalities of cervical, endometrial, and ovarian cancers were 2.1, 1.3, and 3.2 per 100,000 in 2012, respectively. In 2014, 52.2% of cervical cancer patients were classified as stage I, 22.5% as stage II, 10.2% as stage III, and 11.2% as stage IV. In addition, 71.9% of endometrial cancer patients were classified as stage I, 6.0% as stage II, 13.3% as stage III, and 7.5% as stage IV. Finally, 43.2% of ovarian cancer patients were classified as stage I, 9.1% as stage II, 27.6% as stage III, and 7.2% as stage IV. Twelve-point six percent of ovarian cancer patients received neoadjuvant chemotherapy.
Polymer Thin‐Film Transistor Arrays Patterned by Stamping (2005)

Abstract We present a process to stamp semiconductor polymers suitable for the parallel fabrication of thin‐film transistor island arrays. This process is compatible with roll‐to‐roll fabrication. When a chemically treated elastomeric stamp is pressed against a substrate previously coated with the polymer solution, a capillary force drives the polymer solution into the stamp recesses. Simultaneously, the raised features of the stamp in contact with the substrate absorb the solvent. The resulting polymer thin film reproduces the pattern of the raised features of the stamp. Features with lateral dimensions as small as 2 μm are faithfully reproduced. We use this stamping process to fabricate arrays of polymer thin‐film transistors (TFTs) using poly(fluorene‐ co ‐bithiophene) and poly(thiophene) semiconductors.
Antitumor activity of spergualin, a novel antitumor antibiotic. (1986)

Spergualin (SGL), a novel antitumor antibiotic, exhibited strong antitumor activity against transplantable leukemias in mice: L1210, L1210(IMC), P388, P815, C1498, EL-4 and RL male 1. It also exhibited antitumor activity against M5076 fibrosarcoma, AH66 and AH66F rat hepatomas, but not against Meth-A fibrosarcoma, B16 melanoma, Lewis lung carcinoma (LL) and C26 colon adenocarcinoma. The antitumor activity of SGL was administration-schedule dependent. The strongest activity against L1210 was obtained by ip continuous infusion for 7 days or daily ip administration for 9 days. Single ip injection of SGL at 100 mg/kg to mice caused convulsion and death within 15 minutes after injection. Such acute toxicity was not observed by continuous infusion. SGL showed its strongest activity at subtoxic dose against sensitive tumors except for L1210(IMC). Mice implanted ip with L1210(IMC) were cured by treatment with SGL at 3.13 mg/kg/day for 9 days, but died from the tumor at 50 mg/kg/day X 9. The cured mice rejected a second inoculation of up to 10(6) tumor cells. The tumor cells isolated from mice after treatment with the high dose showed resistance to SGL in vivo. Mice implanted sc with L1210(IMC) were also cured by 9 daily ip administrations of SGL at 12.5 mg/kg/day, but solid tumor was observed at the implantation site until 3 days after the final injection of SGL in some cured mice. These results suggest that the therapeutic effect of SGL has a relatively high specificity for leukemias and that the immunological effect is involved in the antitumor activity.
Supplementary Figures S4-S12 from Pathway-Enriched Gene Signature Associated with 53BP1 Response to PARP Inhibition in Triple-Negative Breast Cancer (2023)

&lt;p&gt;Supplementary Figure S4. Cell cycle distributions for veliparib, olaparib, and talazoparib, in A) HCC1143, B) MDAMB231, and C) HCC1806; Supplementary Figure S5. Cell cycle histograms for veliparib, olaparib, and talazoparib, in A) HCC1143, B) MDAMB231, and C) HCC1806 at selected concentrations; Supplementary Figure S6. Cleaved-PARP expression; Supplementary Figure S7. Representative EC50 dose-response curves of normalized percentage of cells positive for 53BP1 for veliparib, olaparib, and talazoparib in A) HCC1143, B) MDAMB231, C) HCC1806, D) HCC1395, and E) MDAMB436; Supplementary Figure S8. IC50 and EC50 values compiled for 8 breast cancer cell lines, for veliparib, olaparib, and talazoparib; Supplementary Figure S9. For each PARP inhibitor, correlations between IC50 values and A) EC50 values for % positive 53BP1, B) EC50 values for 53BP1 foci, C) EC50 values for % positive for cleaved-PARP; Supplementary Figure S10. Summary of Gene Set Enrichment Analysis (GSEA); Supplementary Figure S11. Enrichment plots after gene set enrichment analysis; Supplementary Figure S12. A) Presence of mutations in 63 gene-set in triple-negative breast cancer patients; B) Mutational frequency of 63 pathway enriched genes in triple-negative breast cancer (TNBC), ER-negative, ER-positive, basal, luminal B, and luminal A breast cancer subtypes.&lt;/p&gt;
Control and Suppression of Surface Relief Gratings in Liquid‐Crystalline Perfluoroalkyl–Azobenzene Polymers (2006)

Abstract Semifluorinated azobenzene liquid‐crystalline side‐chain polymers with different perfluoroalkyl lengths are used to develop surface relief gratings (SRGs). With sufficient fluorinated side‐chain lengths, surface relief gratings could be completely suppressed due to the self‐assembled liquid‐crystalline order at the surface. This indicates that there is a surface‐dependent nature to SRG formation. The SRG formation from the semifluorinated azobenzene liquid‐crystalline side‐chain polymers is compared to methoxy‐terminated azobenzene side‐chain polymers, and results show that the perfluoroalkyl–azobenzene polymers require a longer formation time than the methoxy‐terminated polymers.
SCALABLE PARALLEL DIRECT VOLUME RENDERING FOR NONRECTILINEAR COMPUTATIONAL GRIDS (Ph.D. Thesis) (1993)

Various approaches to the problem of parallelizing direct volume rendering algorithms are discussed, and a scalable approach to parallel direct volume rendering of nonrectilinear computational grids is presented. The algorithm is general enough to handle non-convex grids and cells, grids with voids, grids constructed from multiple grids (multi-block grids), and embedded geometrical primitives. The algorithm is designed for a highly parallel MIMD architecture which features both local memory and shared memory with non-uniform memory access times. It has beem implemented on a BBN TC2000 and benchmarked on several datasets. An analysis of the speedup and efficiency of the algorithm is given and any sources of inefficiency are indentified. The trade-off between load balancing requirements and the loss of coherence due to the image-space task decomposition is examined. A variation of the algorithm which provides fast image updated for a changing transfer function is also presented. A distributed approach to controlling the execution of the volume render is used and the graphical user interface designed for this purpose is briefly described.
209-05: Does flecainide pre-treatment helps to identify the most important players? (2016)

Introduction: The identification of AF sources maintaining AF is possible using ECGM (ECG mapping). We sought to study if the rotors persisting after Flecainide (Fleca) infusion could be associated to AF termination during ablation. Methods: ECGM was used to prospectively acquire AF maps before and after Fleca infusion, the day before persistent AF ablation. Phase mapping of AF were obtained with biatrial geometry and relative electrode positions from a CT scan and an array of 252 body surface electrodes. Long ventricular pauses were mapped 10 min after Fleca infusion. The AF drivers were targeted during ablation, blinded of the results of the Fleca map. Results: 13 pts (60 ± 10, 11 m) with persistent AF (9 ± 4mo) had a dramatic reduction of rotors from 81 ± 38 rotors in 7 ± 1 regions to 56 ± 52 in 4 ± 2 regions after Fleca infusion (p = 0.01 and <10-3respectively). AF termination was obtained in 11/13 pts (85%) after 25 ± 13 min of RF. Termination site was in a region where rotors persisted after Fleca in 9/11 pts (82%). The 2 pts without AF termination had no reduction in rotor's number after Fleca: 44 unchanged in 1, and 104 to 126 in the other.
A Wiener Filter Approach to Microphone Leakage Reduction in Close-Microphone Applications (2011)

Microphone leakage is one of the most prevalent problems in audio applications involving multiple instruments and multiple microphones. Currently, sound engineers have limited solutions available to them. In this paper, the applicability of two widely used signal enhancement methods to this problem is discussed, namely blind source separation and noise suppression. By extending previous work, it is shown that the noise suppression framework is a valid choice and can effectively address the problem of microphone leakage. Here, an extended form of the single channel Wiener filter is used which takes into account the individual audio sources to derive a multichannel noise term. A novel power spectral density (PSD) estimation method is also proposed based on the identification of dominant frequency bins by examining the microphone and output signal PSDs. The performance of the method is examined for simulated environments with various source-microphone setups and it is shown that the proposed approach efficiently suppresses leakage.
Auranofin Attenuates Non-Alcoholic Fatty Liver Disease by Suppressing Lipid Accumulation and NLRP3 Inflammasome-Mediated Hepatic Inflammation In Vivo and In Vitro (2020)

Non-alcoholic fatty liver disease (NAFLD) causes liver dysfunction and is associated with obesity and type 2 diabetes. Chronic inflammation is associated not only with the development of NAFLD, but also with hepatic diseases, including steatohepatitis, cirrhosis, and hepatocellular carcinoma. Auranofin is a treatment for rheumatoid arthritis and has recently been reported to have potential effects against a variety of diseases, including inflammation, cancer, and viral infection. In this study, auranofin may be considered as a new treatment for the management of metabolic syndrome, as well as in the treatment of NAFLD through immunomodulation. To determine the effect of auranofin on NAFLD, C57BL/6 mice were randomly grouped, fed a regular diet or a high fat diet (HFD), and injected with normal saline or auranofin for 8 weeks. Auranofin significantly decreased the body weight, epididymal fat weight, serum aspartate aminotransferase (AST), and glucose, as well as the serum triglyceride, cholesterol, and low-density lipoprotein cholesterol levels as compared to the HFD group. We also observed that hepatic steatosis was increased in the HFD group and was suppressed by auranofin treatment. In addition, auranofin suppressed the expressions of interleukin (IL)-1β, IL-18, caspase-1, and the NOD-like receptor family pyrin domain containing 3 (NLRP3) in the liver tissue. Furthermore, the expression of NADPH oxidase 4 and peroxisome proliferator-activated receptor γ (PPARγ), which are a major source of oxidative stress and a regulator of adipogenesis, respectively, were also decreased by auranofin. In addition, primary mouse hepatocytes were incubated with lipopolysaccharide (LPS) and palmitic acid (PA) to induce lipid accumulation and hepatic inflammation for an in vitro model. Auranofin could significantly inhibit LPS- and PA-induced inflammatory activity including nitric oxide and NLRP3 inflammasome-mediated cytokines. The results of this study demonstrate that auranofin treatment inhibits the characteristics of NAFLD through the inhibition of NLRP3 inflammasome. Therefore, auranofin may have potential as a candidate for improving NAFLD symptoms.
Compensatory periplasmic nitrate reductase activity supports anaerobic growth ofPseudomonas aeruginosaPAO1 in the absence of membrane nitrate reductase (2009)

Nitrate serves as a terminal electron acceptor under anaerobic conditions in Pseudomonas aeruginosa. Reduction of nitrate to nitrite generates a transmembrane proton motive force allowing ATP synthesis and anaerobic growth. The inner membrane-bound nitrate reductase NarGHI is encoded within the narK1K2GHJI operon, and the periplasmic nitrate reductase NapAB is encoded within the napEFDABC operon. The roles of the 2 dissimilatory nitrate reductases in anaerobic growth, and the regulation of their expressions, were examined by use of a set of deletion mutants in P. aeruginosa PAO1. NarGHI mutants were unable to grow anaerobically, but plate cultures remained viable up to 120 h. In contrast, the nitrate sensor-response regulator mutant DeltanarXL displayed growth arrest initially, but resumed growth after 72 h and reached the early stationary phase in liquid culture after 120 h. Genetic, transcriptional, and biochemical studies demonstrated that anaerobic growth recovery by the NarXL mutant was the result of NapAB periplasmic nitrate reductase expression. A novel transcriptional start site for napEFDABC expression was identified in the NarXL mutant grown anaerobically. Furthermore, mutagenesis of a consensus NarL-binding site monomer upstream of the novel transcriptional start site restored anaerobic growth recovery in the NarXL mutant. The data suggest that during anaerobic growth of wild-type P. aeruginosa PAO1, the nitrate response regulator NarL directly represses expression of periplasmic nitrate reductase, while inducing maximal expression of membrane nitrate reductase.
Error performance of equalizers based on sparse and dynamic channel estimation (2006)

For broadband communications in the very shallow water environment, it has been shown that both model-based dynamic channel estimation and sparse channel estimation are capable of reducing the signal prediction error by several dB [W. Li and J. C. Preisig, J. Acoust. Soc. Am. 118, 2014 (2005)]. Dynamic channel estimation is based on explicit modeling of the rapid channel variations; sparse channel estimation exploits the channel structure formed by the resolved multipath arrivals. In this paper, the error performance of the equalizer based on these channel estimators are analyzed, demonstrated through experimental results and compared with the performance of equalizers that do not explicitly model and exploit the channel dynamics and structure. [Work supported by ONR Ocean Acoustics.]
Quasi-CW Pumping of a Single-Frequency Fiber Amplifier for Efficient SHG in PPLN Crystals with Reduced Thermal Load (2021)

Single-frequency lasers are essential for high-resolution spectroscopy and sensing applications as they combine high-frequency stability with low noise and high output power stability. For many of these applications, there is increasing interest in power-scaling single-frequency sources, both in the near-infrared and visible spectral range. We report the second-harmonic generation of 670 µJ at 532 nm of a single-frequency fiber amplifier signal operating in the quasi-continuous-wave mode in a 10-mm periodically poled Mg-doped lithium niobate (MgO:PPLN) crystal, while increasing compactness. To the best of our knowledge, this is the highest pulse energy generated in this crystal, which may find applications in the visible and UV such as remote Raman spectroscopy.
Solution Structure of a Disulfide Cross-Linked DNA Hairpin (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolution Structure of a Disulfide Cross-Linked DNA HairpinHong Wang, Erik R. P. Zuiderweg, and Gary D. GlickCite this: J. Am. Chem. Soc. 1995, 117, 11, 2981–2991Publication Date (Print):March 1, 1995Publication History Published online1 May 2002Published inissue 1 March 1995https://pubs.acs.org/doi/10.1021/ja00116a003https://doi.org/10.1021/ja00116a003research-articleACS PublicationsRequest reuse permissionsArticle Views96Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Evaluation of metabolism of azo dyes and their effects onStaphylococcus aureusmetabolome (2017)

Dyes containing one or more azo linkages are widely applied in cosmetics, tattooing, food and drinks, pharmaceuticals, printing inks, plastics, leather, as well as paper industries. Previously we reported that bacteria living on human skin have the ability to reduce some azo dyes to aromatic amines, which raises potential safety concerns regarding human dermal exposure to azo dyes such as those in tattoo ink and cosmetic colorant formulations. To comprehensively investigate azo dye-induced toxicity by skin bacteria activation, it is very critical to understand the mechanism of metabolism of the azo dyes at the systems biology level. In this study, an LC/MS-based metabolomics approach was employed to globally investigate metabolism of azo dyes by Staphylococcus aureus as well as their effects on the metabolome of the bacterium. Growth of S. aureus in the presence of Sudan III or Orange II was not affected during the incubation period. Metabolomics results showed that Sudan III was metabolized to 4-(phenyldiazenyl) aniline (48%), 1-[(4-aminophenyl) diazenyl]-2-naphthol (4%) and eicosenoic acid Sudan III (0.9%). These findings indicated that the azo bond close to naphthalene group of Sudan III was preferentially cleaved compared with the other azo bond. The metabolite from Orange II was identified as 4-aminobenzene sulfonic acid (35%). A much higher amount of Orange II (~90×) was detected in the cell pellets from the active viable cells compared with those from boiled cells incubated with the same concentration of Orange II. This finding suggests that Orange II was primarily transported into the S. aureus cells for metabolism, instead of the theory that the azo dye metabolism occurs extracellularly. In addition, the metabolomics results showed that Sudan III affected energy pathways of the S. aureus cells, while Orange II had less noticeable effects on the cells. In summary, this study provided novel information regarding azo dye metabolism by the skin bacterium, the effects of azo dyes on the bacterial cells and the important role on the toxicity and/or inactivation of these compounds due to microbial metabolism.
Fault Detection via modified Principal Direction Divisive Partitioning and application to aerospace electro-mechanical actuators (2014)

In this paper, the use of the Principal Direction Divisive Partitioning (PDDP) method for unsupervised learning is discussed and analyzed with a focus on fault detection applications. Specifically, a geometric limit of the standard algorithm is highlighted by means of a simulation example and a modified version of PDDP is introduced. Such a method is shown to correctly perform data clustering also when the standard algorithm fails. The modified strategy is based on the use of a Chi-squared statistical test and offers more guarantees in terms of detection of a wrong functioning of the system. The proposed algorithm is finally experimentally tested on a fault detection application for aerospace electro-mechanical actuators, for which a comparison with k-means and fuzzy k-means approaches is also provided.
(Invited) Power Loss Reduction in Perforated-Channel HFET Switches (2015)

The work presents a novel perforated channel field-effect transistor (PC-FET) design that reduces the power losses and significantly improves the efficiency of power electronics systems. The improvement is achieved by making use of a strong current spreading effect in the source-gate and gate-drain spacing and by lateral/vertical profiling of the channel under the gate. The reduction of the switch on-resistance and output capacitance reduces the conversion loss in the power switch by more than a factor of 2.
Demonstration of targeted crossovers in hybrid maize using CRISPR technology (2022)

Naturally occurring chromosomal crossovers (CO) during meiosis are a key driver of genetic diversity. The ability to target CO at specific allelic loci in hybrid plants would provide an advantage to the plant breeding process by facilitating trait introgression, and potentially increasing the rate of genetic gain. We present the first demonstration of targeted CO in hybrid maize utilizing the CRISPR Cas12a system. Our experiments showed that stable and heritable targeted CO can be produced in F1 somatic cells using Cas12a at a significantly higher rate than the natural CO in the same interval. Molecular characterization of the recombinant plants demonstrated that the targeted CO were driven by the non-homologous end joining (NHEJ) or HDR repair pathways, presumably during the mitotic cell cycle. These results are a step towards the use of RNA-guided nuclease technology to simplify the creation of targeted genome combinations in progeny and accelerate breeding.
Double U Suturing Technique for Repair of the Rotator Cuff (2002)

As the understanding of pathology of the rotator cuff has evolved, so have surgical techniques in rotator cuff surgery. The ideal rotator cuff repair should have good initial fixation strength, allowing mobilization of the extremity during the healing phase. The authors present their indications and technique for rotator cuff repair using transosseous sutures. This technique can be employed through a standard open or mini open approach. The initial strength of this repair technique allows early, aggressive rehabilitation, minimizing potential for postoperative stiffness. Furthermore, this technique has proven clinically successful in 96% of the cases in which it was used.
Is There a Future in Microlithography? (2003)

The <i>Journal of Micro/Nanopatterning, Materials, and Metrology</i> (JM3) publishes peer-reviewed papers on the core enabling technologies that address the patterning needs of the electronics industry.