gebhart/patrepeval huggingface dataset:
Expression of Streptococcal M Protein in Escherichia coli (1983)

The structural gene for group A streptococcal M protein, the fibrillar surface molecule enabling the organism to resist phagocytosis, has been cloned into Escherichia coli. The molecule produced by Escherichia coli is slightly larger than the M protein isolated by solubilization of the streptococcal cell wall, but is similar in size to that secreted by streptococcal protoplast and L forms. Immunologically, the molecule synthesized by Escherichia coli has the same type-specific determinants as the streptococcal M protein.
Cellular Reaction to Hyperphysiological Loading (1994)

Conference Abstract| January 01 1994 Cellular Reaction to Hyperphysiological Loading G Leivseth; G Leivseth *Akademie fur Manuelle Medizine an der Wesfalische Wilhelms Universitat2Experimentelle Orthopadie, Westfalische Wilhelms Universitat. Domagkstr. 3 48129 Munster, FRG Search for other works by this author on: This Site PubMed Google Scholar T Ozaki; T Ozaki *Akademie fur Manuelle Medizine an der Wesfalische Wilhelms Universitat3Experimentelle Orthopadie, Westfalische Wilhelms Universitat. Domagkstr. 3 48129 Munster, FRG Search for other works by this author on: This Site PubMed Google Scholar DB Jones DB Jones *Akademie fur Manuelle Medizine an der Wesfalische Wilhelms Universitat4Experimentelle Orthopadie, Westfalische Wilhelms Universitat. Domagkstr. 3 48129 Munster, FRG Search for other works by this author on: This Site PubMed Google Scholar Clin Sci (Lond) (1994) 87 (s1): 127. https://doi.org/10.1042/cs087s127 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation G Leivseth, T Ozaki, DB Jones; Cellular Reaction to Hyperphysiological Loading. Clin Sci (Lond) 1 January 1994; 87 (s1): 127. doi: https://doi.org/10.1042/cs087s127 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsClinical Science Search Advanced Search This content is only available as a PDF. © 1994 The Biochemical Society and the Medical Research Society1994 Article PDF first page preview Close Modal You do not currently have access to this content.
Ballistic Missile Boost Phase Acceleration Reconstruction using Wavelet Multi-resolution Analysis (2017)

In recent years, the accurate characterization of the boost phase of a missile's flight has become a more challenging and prominent research topic as the noise level is extremely large relative to the quantity of interest. Reconstructing the boost phase acceleration profile of a ballistic missile from state observation is of interest to the technical intelligence community, ballistic missile defense, as well as the missile warning community. There are methods available such as Tikhonov regularization if the noise level is not too large. However, if the noise environment is very high most algorithms will perform poorly. In this paper, we explore the problem of estimating the thrust of a missile from very noisy estimates of its position over time by using wavelet techniques. Several wavelet basis functions and multi-resolution methods are explored to yield the most effective solution to this problem. These techniques have been successfully used on actual rocket-launch data in the past. Our method can be applied to US boost-phase missile defense such as protection of US homeland against nuclear attacks, other weapons of mass destructions or conventional ballistic missile attacks, military bases, and protecting US allies and partners.
ChemInform Abstract: Synthesis and Synthetic Utilization of α‐Functionalized Vinylphosphonates Bearing β‐Oxy or β‐Thio Substituents. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A 15–22 Gbps Serial Link in 28 nm CMOS With Direct DFE (2014)

A half-duplex serial link design that is capable of 22 Gbps operation over PCB channels with up to 20 dB of loss is presented. A current-mode transmitter can be configured either as a pre-cursor or post-cursor 2-tap FIR filter. The receiver consists of a trans-admittance-trans-impedance single-stage linear equalizer that can provide 10 dB of high-frequency gain without the use of peaking inductors. The CTLE is followed by an half-rate 2-tap decision feedback equalizer with direct feedback. To mitigate long-tail intersymbol interference in a power-efficient manner, a third DFE tap employs a single-pole IIR filter. A 15-22 GHz LC-PLL provides quadrature clocks to a 16-lane macro. The 16-lane macro occupies 1.66 mm × 1.6 mm in a 28 nm CMOS process and is packaged in a 45 mm × 45 mm flip-chip MCM module. The link operates from two power supplies at 1.35 V and 0.9 V with a BER and a power efficiency of 6.5 mW/Gbps at 20 Gbps.
Wall Heating Effect on Crystallization of Low-Temperature Deposited Silicon Films from an Inductively-Coupled Plasma (2001)

The influence of vessel-wall temperature T w on the grain size of poly-Si films deposited on a low-temperature (300°C) substrate by an inductively-coupled SiH 4 /H 2 plasma is investigated. The grain size is reduced after a clean vessel wall at T w ∼100°C experiences long SiH 4 /H 2 discharge. This reduction in the grain size due to SiH 4 /H 2 discharge duration can be suppressed by heating the wall to T w ∼300°C. To understand the mechanism, the H atom density in the plasma is measured from the ratio of H α /H β emission intensities. The H atom density is found to decrease monotonically with the discharge time at T w ∼100°C, and this H density decrease is suppressed by increasing the wall temperature to ∼300°C.
SURFACE ALLOANTIGENS OF PLASMA CELLS (1970)

A serological study of immunoglobulin-forming cells of the mouse, normal and malignant, shows that they lack all known surface differentiation antigens of the thymocyte-lymphocyte axis: TL, theta, Ly-A, Ly-B, and MSLA. Two systems of normal alloantigens are expressed on these cells, H-2 and a new system named PC. The gene Pca (Plasma cell antigen) which specifies PC.1 alloantigen segregates as a mendelian dominant not closely linked with H-2. This cell surface antigen is absent from thymocytes, leukemias, and very probably from thymus-derived lymphocytes also; it is present on cells of the liver, kidney, brain, and lymph nodes as well as on hemolytic plaque-forming cells of the spleen, and on myelomas. So PC.1 is properly classified as a differentiation alloantigen. The strain distribution of PC.1 does not conform to that of any known immunoglobulin allotype or cell surface alloantigen previously described. Thus the cell surface antigens of immunoglobulin-producing cells are clearly different from those of cells belonging to the thymocyte-lymphocyte axis. Each family of cells has distinctive alloantigens, and the two families share alloantigens of only one known system, H-2. This implies that either immunoglobulin-producing cells are not derived from thymic lymphocytes, or if they are, the program responsible for the transition must include extensive revision of cell surface structure.
Metabolic profiling of charged metabolites in association with menopausal status in Japanese community-dwelling midlife women: Tsuruoka Metabolomic Cohort Study (2021)

Multiple charged metabolites were associated with women's menopausal status, showing a gradual increase as women shifted from pre-, to peri-, to postmenopause. These findings might reflect the early changes behind the increased risk of dyslipidemia, diabetes, cardiovascular disease, and osteoporosis in later life.
Magnetically tunable fiber Bragg gratings (2003)

We believe we report the first demonstration of a broad-range (15.7 nm) tuning of fiber Bragg grating using fast, programmable, and latchable magnetic actuation. A key advantage is that the device requires no power except when shifting wavelengths.
Achievable Throughput With Block Diagonalization On Ofdm Indoor Demonstrator (2013)

Publication in the conference proceedings of EUSIPCO, Marrakech, Morocco, 2013
Synthetic Micelle Sensitive to IR Light via a Two-Photon Process (2005)

A micellar assembly of molecules constituted of poly(ethylene glycol) as the hydrophilic component and 2-diazo-1,2-naphthoquinone as the hydrophobic component was shown to be destroyed in a two-photon photoreaction triggered by infrared light with release of an encapsulated fluorescent probe molecule.
STM of freeze-fracture replicas: Problems and promises (1993)

The Scanning Tunneling Microscope (STM) offers exciting new ways of imaging surfaces of biological or organic materials with resolution to the sub-molecular scale. Rigid, conductive surfaces can readily be imaged with the STM with atomic resolution. Unfortunately, organic surfaces are neither sufficiently conductive or rigid enough to be examined directly with the STM. At present, nonconductive surfaces can be examined in two ways: 1) Using the AFM, which measures the deflection of a weak spring as it is dragged across the surface, or 2) coating or replicating non-conductive surfaces with metal layers so as to make them conductive, then imaging with the STM. However, we have found that the conventional freeze-fracture technique, while extremely useful for imaging bulk organic materials with STM, must be modified considerably for optimal use in the STM.
Targeted Inactivation of Snail Family EMT Regulatory Factors by a Co(III)-Ebox Conjugate (2012)

Snail family proteins are core EMT (epithelial-mesenchymal transition) regulatory factors that play essential roles in both development and disease processes and have been associated with metastasis in carcinomas. Snail factors are required for the formation of neural crest stem cells in most vertebrate embryos, as well as for the migratory invasive behavior of these cells. Snail factors have recently been linked to the formation of cancer stem cells, and expression of Snail proteins may be associated with tumor recurrence and resistance to chemotherapy and radiotherapy. We report that Co(III)-Ebox is a potent inhibitor of Snail-mediated transcriptional repression in breast cancer cells and in the neural crest of Xenopus. We further show that the activity of Co(III)-Ebox can be modulated by temperature, increasing the utility of this conjugate as a Snail inhibitor in model organisms. We exploit this feature to further delineate the requirements for Snail function during neural crest development, showing that in addition to the roles that Snail factors play in neural crest precursor formation and neural crest EMT/migration, inhibition of Snail function after the onset of neural crest migration leads to a loss of neural crest derived melanocytes. Co(III)-Ebox-mediated inhibition therefore provides a powerful tool for analysing the function of these core EMT factors with unparalleled temporal resolution. Moreover, the potency of Co(III)-Ebox as a Snail inhibitor in breast cancer cells suggests its potential as a therapeutic inhibitor of tumor progression and metastasis.
An electrode-assisted anaerobic digestion process for the production of high-quality biogas (2019)

Biogas is a sustainable, renewable energy source generated from organic waste degradation during anaerobic digestion (AD). AD is applied for treating different types of wastewater, mostly containing high organic load. However, AD practice is still limited due to the low quality of the produced biogas. Upgrading biogas to natural gas quality (>90% CH<sub>4</sub>) is essential for broad applications. Here, an innovative bio-electrochemically assisted AD process was developed, combining wastewater treatment and biogas upgrading. This process was based on a microbial electrolysis cell (MEC) that produced hydrogen from wastewater at a relatively high efficiency, followed by high-rate anaerobic systems for completing biodegradation of organic matter and an in situ bio-methanation process. Results showed that CH<sub>4</sub> production yield was substantially improved upon coupling of the MEC with the AD system. Interestingly, CH<sub>4</sub> production yield increase was most notable once circulation between AD and MEC was applied, while current density was not markedly affected by the circulation rates. The microbial community analysis confirmed that the MEC enhanced hydrogen production, leading to the enrichment of hydrogenotrophic methanogens. Thus, directing soluble hydrogen from the MEC to AD is plausible, and has great potential for biogas upgrading, avoiding the need for direct hydrogen harvesting.
Cytokine-Induced Human Multinucleated Giant Cells Have Enhanced Candidacidal Activity and Oxidative Capacity Compared with Macrophages (1992)

The granulomatous response to infection is characterized by formation of multinucleated giant cells (MGC). A model has been developed for the study of MGC using fresh human peripheral blood monocytes cultured in medium supplemented with autologous serum and a combination of recombinant human interferon-gamma and interleukin-3 (100 units/mL each). Differential Giemsa staining demonstrated a 53% increase in candidacidal activity of MGC (35.1% +/- 2.0% of ingested organisms were killed by MGC) compared with identically cultured mononuclear macrophages (which killed 22.9% +/- 1.8% of organisms ingested; P less than .05). There was no significant difference in the number of organisms ingested. MGC stimulated with phorbol myristate acetate produced 2.2 times as much superoxide anion per unit of cytoplasmic protein as identically cultured and stimulated macrophages (34.3 vs. 16.2 nmol of superoxide/microgram of cell protein; P less than .01). This was corroborated with single-cell measurements of oxidative activity using digital image analysis. These observations support the hypothesis that MGC have an advantage in microbicidal activity over macrophages that may be due, at least in part, to enhanced oxidative capacity.
Efficacious photocurrent generation and carrier transport by quantum dot decorated carbon nanotubes (2008)

CdSe/ZnS core/shell quantum dots have been decorated on thin multiwalled and singlewalled carbon nanotubes (CNTs) by chemical functionalization and substrate gate-bias control. CdSe quantum dots were negatively charged by adding mercaptoacetic acid (MAA). The silicon oxide substrate was decorated by octadecyltrichlorosilane (OTS) and converted to hydrophobic surface. The negatively charged CdSe/ZnS NCs were adsorbed on the SWCNT surface by applying the negative gate bias. The selective adsorption of CdSe/ZnS quantum dots on SWCNTs was confirmed by confocal laser scanning microscope. Quantum dots decorated carbon nanotubes have been used for effective photogenaration and carrier transport through the organic photovoltaic device which has fabricated using effective polymers. The results clearly indicate the efficient photocurrent generation and carrier transport which effectively increased the efficiency of the device for the next generation organic solar cell applications.
Protection against ultraviolet A‐induced oxidative damage in normal human epidermal keratinocytes under post‐menopausal conditions by an ultraviolet A‐activated caged‐iron chelator: a pilot study (2011)

2-PNE-PIH may be a useful deterrent against UVA-induced oxidative stress in post-menopausal women.
Assessment of the effect of the dual orexin receptor antagonist daridorexant on various indices of disease severity in patients with mild to moderate obstructive sleep apnea (2022)

ClinicalTrials.gov NCT03765294. A study to investigate the effects of ACT-541468 on nighttime respiratory function in patients with mild to moderate obstructive sleep apnea. https://clinicaltrials.gov/ct2/show/NCT03765294.
Figure S1 from Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor (2023)

&lt;p&gt;JBJ-04-125-02 is more potent than EAI045 and JBJ-02-112-05 in the presence of cetuximab and is effective in inhibiting EGFR-dependent proliferation and phosphorylation in L858R/ C797S Ba/F3 cells.&lt;/p&gt;
From hours to seconds: towards 100x faster quantitative phase imaging via differentiable microscopy (Conference Presentation) (2023)

With applications ranging from metabolomics to histopathology, quantitative phase microscopy (QPM) is a powerful label-free imaging modality. However, the speed of current QPM systems is limited by electronic hardware. To improve throughput further, here we propose differentiable optical-electronic quantitative phase microscopy (∂μ) that acquires images in a compressed form such that more information can be transferred beyond the electronic hardware bottleneck. The proposed microscopy uses optical feature extractors as image compressors. The resultant intensity distribution is then decompressed into QPM images by a reconstruction network. By optimizing optical-electronic parameters in an end-to-end manner, our method can improve the QPI throughput from Hours to Seconds (more than an order of magnitude).
Femtosecond Optical Parametric Amplification using &#x03B2;-BaB<inf>2</inf>O<inf>4</inf> and BiB<inf>3</inf>O<inf>6</inf> consecutively (2009)

We present a femtosecond Optical Parametric Amplificator (OPA) which was conceived to perform surgical interventions on eyes using eye-safe wavelengths. It is pumped by a Ti: sapphire laser. An OPA scheme using consecutively beta-BaB <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> (BBO) crystal and BiB <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sub> (BiBO) provides the required behaviour. For the first stage, a type I BBO is used because of it angular phase-matching selectivity. In the second stage, a type I BiBO allows a very good gain from 1.2 to 2.7 mum, while having identical angular phase-matching properties for all these wavelengths. Type I crystals are used as the pump polarisation and signal polarisation are perpendicular which allows to separate them easily. In our case, only nonlinear parametric effects are used which has a small compression effect. Consequently, the signal remains as long as the pump and a compressor is not needed. To summarise, the signal properties are : 50 fs pulse length, 1 kHz repetition rate and more than 150 muJ pulse energy, which correspond to an efficiency of almost 20 %.
An IA-32 processor with a wide voltage operating range in 32nm CMOS (2012)

This article consists of a collection of slides from the author's conference presentation on the deployment of an Intel IA-32 processor with a wide range of voltage operating ranges in 32nm CMOS technology. Some of the specific topics discussed include: the purpose of near threshold voltage and wide dynamic range capabilities; design challenges; a description of the Intel Claremont prototype; design strategies and methodologies; and key areas of product and system improvement
Complete Genome Sequences of Three Pseudomonas aeruginosa Isolates with Phenotypes of Polymyxin B Adaptation and Inducible Resistance (2011)

Clinical "superbug" isolates of Pseudomonas aeruginosa were previously observed to be resistant to several antibiotics, including polymyxin B, and/or to have a distinct, reproducible adaptive polymyxin resistance phenotype, identified by observing "skipped" wells (appearance of extra turbid wells) during broth microdilution testing. Here we report the complete assembled draft genome sequences of three such polymyxin resistant P. aeruginosa strains (9BR, 19BR, and 213BR).
O4‐06‐01: A highly sensitive assay for detection of Aβ aggreates in body fluids: A method for early diagnosis of Alzheimer's disease? (2010)

Today, Alzheimer's disease (AD) can be diagnosed with certainty only post mortem based on the presence of insoluble amyloid-β peptide (Aβ) aggregates and neurofibrillary tangles in the patient's brain tissue. A biomarker method for early diagnosis, prognosis and therapy monitoring of AD is urgently needed. Regarding the amyloid cascade hypothesis, Aβ oligomers and aggregates are directly involved in the pathologic process. Aβ aggregates might therefore be useful as a biomarker in body fluids. We have developed an ultra-sensitive assay system for the detection and investigation of Aβ aggregates in body fluids, called surface-FIDA. The aggregates are immobilized on a glass surface, labelled by specific fluorescent probes and detected using confocal spectroscopy. The assay was validated with synthetically prepared Aβ, showing linearity over a wide range of Aβ amounts in the ng up to pg range. First results show a nice distinction between AD diseased people and non-demented controls by analysing cerebrospinal fluids (CSF) with surface-FIDA. Surface-FIDA in its first version was based on fluorescence correlation spectroscopy (FCS) methodologies. Here, we show that aggregate detection and quantitation can also be performed using a laser scanning microscope setup and is even nicely suitable for detailed characterization of Aβ aggregates, e.g. in respect to the composition of each aggregate. Additionally, we could employ high-resolution microscopy methods like “direct stochastic optical reconstruction microscopy” (dSTORM) for a more detailed Aβ aggregate detection. Here we describe that surface FIDA is sensitive and specific enough to count single Aβ aggregates, possibly to be used as a minimally invasive tool for early diagnosis of AD, on line monitoring of disease progression and monitoring of therapeutic approaches. An important goal will be the investigation of any correlation of Aβ aggregate number, size and composition in body fluids like blood and CSF with clinical disease progress.
Transmission electron microscopy specimen holder for simultaneous in situ heating and electrical resistance measurements (2004)

A transmission electron microscopy (TEM) specimen holder has been developed for the measurement of the electrical resistance of a TEM sample as a function of temperature. A custom TEM heating holder was modified for this purpose. Eight feedthrough wires were passed through the specimen holder; (i) providing current to the heater, (ii) allowing for the measurement of the hot stage temperature, and (iii) enabling the measurement of the electrical resistance of the sample. This configuration creates the opportunity to directly correlate changes in the resistance to microstructural changes as a function of temperature. The working of the holder is demonstrated by studies on a phase transformation in Al–Ge films. In this way, a direct correlation was found between changes in resistance and microstructure as a function of temperature.
Supplementary Figures and Tables from Distinctive Subpopulations of Stromal Cells Are Present in Human Lymph Nodes Infiltrated with Melanoma (2023)

&lt;p&gt;Supplementary Figures 1-6 and Tables 1-7&lt;/p&gt;