gebhart/patrepeval huggingface dataset:
Supplementary Data from MicroRNAs modulate the chemosensitivity of tumor cells (2023)

Supplementary Data from MicroRNAs modulate the chemosensitivity of tumor cells
Nonlinear analysis of the deformation and breakup of viscous microjets using the method of lines (2010)

Abstract We present a numerical model for predicting the instability and breakup of viscous microjets of Newtonian fluid. We adopt a one‐dimensional slender‐jet approximation and obtain the equations of motion in the form of a pair of coupled nonlinear partial differential equations (PDEs). We solve these equations using the method of lines, wherein the PDEs are transformed to a system of ordinary differential equations for the nodal values of the jet variables on a uniform staggered grid. We use the model to predict the instability and satellite formation in infinite microthreads of fluid and continuous microjets that emanate from an orifice. For the microthread analysis, we take into account arbitrary initial perturbations of the free‐surface and jet velocity, as well as Marangoni instability that is due to an arbitrary variation in the surface tension. For the continuous nozzle‐driven jet analysis, we take into account arbitrary time‐dependent perturbations of the free‐surface, velocity and/or surface tension as boundary conditions at the nozzle orifice. We validate the model using established computational data, as well as axisymmetric, volume of fluid (VOF) computational fluid dynamic (CFD) simulations. The key advantages of the model are its ease of implementation and speed of computation, which is several orders of magnitude faster than the VOF CFD simulations. The model enables rapid parametric analysis of jet breakup and satellite formation as a function of jet dimensions, modulation parameters, and fluid rheology. Copyright © 2010 John Wiley &amp; Sons, Ltd.
A First Study of Langmuir−Blodgett Films of 1-[N-(n-Hexadecyl)-4-pyridinio]-2-[5-(dicyano- methanidyl)thien-2-yl]ethene (1997)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTA First Study of Langmuir−Blodgett Films of 1-[N-(n-Hexadecyl)-4-pyridinio]-2-[5-(dicyano- methanidyl)thien-2-yl]etheneRiccardo Ricceri, Alessandro Abbotto, Antonio Facchetti, Giorgio A. Pagani, and Gabriella GabrielliView Author Information Department of Chemistry, University of Florence, via G. Capponi, 9, I-50121 Firenze, Italy, and Department of Organic and Industrial Chemistry, University of Milan, via Golgi 19, I-20133 Milano, Italy Cite this: Langmuir 1997, 13, 15, 4182–4184Publication Date (Web):July 23, 1997Publication History Published online23 July 1997Published inissue 1 July 1997https://pubs.acs.org/doi/10.1021/la970134zhttps://doi.org/10.1021/la970134zbrief-reportACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views61Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Absorption,Compression,Dyes and pigments,Monolayers,Thin films Get e-Alerts
Zero vs. &#x03B5; error in interference channels (2013)

Traditional studies of multi-source, multi-terminal interference channels typically allow a vanishing probability of error in communication. Motivated by the study of network coding, this work addresses the task of quantifying the loss in rate when insisting on zero error communication in the context of interference channels.
Efficient System Tracking With Decomposable Graph-Structured Inputs and Application to Adaptive Equalization With Cyclostationary Inputs (2018)

This paper introduces the graph-structured recursive least squares (GS-RLS) algorithm, which is a very efficient means to track a linear time-varying system when the inputs to the system have structure that can be modeled using a decomposable Gaussian graphical model. For graphs with small clique sizes, it is shown that GS-RLS can achieve tracking performance very close to that of the conventional RLS algorithm for a fraction of the computational cost. In particular, after proving that the outputs of wide-sense stationary time-varying communication channels have graphical model structure if the inputs are cyclostationary, significant computational gains are realized for adaptive equalization of the time-varying underwater acoustic communication channel using the GS-RLS algorithm. This is verified using field data from the SPACE08 underwater acoustic communication experiment.
Supplementary Tables S1-S9 from Characterization of LY3023414, a Novel PI3K/mTOR Dual Inhibitor Eliciting Transient Target Modulation to Impede Tumor Growth (2023)

&lt;p&gt;PDF - 182 KB, Table S1. Kinase selectivity profile for LY3023414 in Cerep and Life Technologies assays based on a 3-point concentration response curve; Table S2. In vitro inhibitory activity of LY3023414 against kinases in a PC3 cell lysate measured in the KiNativ assay based on a 3-point concentration response curve; Table S3. In vitro cell-based target inhibition in SKOV3, A2780, and AsPC-1; Table S4. Summary of pathway-relevant genetic alterations in cancer cell line panel and in selected patient-derived xenograft tumor models tested; Table S5. Activated caspase-3/7 levels in cell lines treated with 2.5 μM LY3023414 for 48 hours; Table S6. In vitro combination studies with LY3023414 and standard of care agents in various cancer cell lines; Table S7. Time course of in vivo target inhibition in U87 MG xenograft tumors after oral administration of 15 and 30 mg/kg LY3023414; Table S8. Summary of LY3023414 monotherapy efficacy in patient-derived xenograft tumor models; Table S9. Summary of LY3023414 combination efficacy in patient-derived xenograft squamous non-small cell lung cancer (NSCLC) tumor models.&lt;/p&gt;
Low-complexity near-MAP decoding of large non-orthogonal STBCs using PDA (2009)

Non-orthogonal space-time block codes (STBC) from cyclic division algebras (CDA) are attractive because they can simultaneously achieve both high spectral efficiencies (same spectral efficiency as in V-BLAST for a given number of transmit antennas) as well as full transmit diversity. Decoding of non-orthogonal STBCs with hundreds of dimensions has been a challenge. In this paper, we present a probabilistic data association (PDA) based algorithm for decoding non-orthogonal STBCs with large dimensions. Our simulation results show that the proposed PDA-based algorithm achieves near SISO AWGN uncoded BER as well as near-capacity coded BER (within 5 dB of the theoretical capacity) for large non-orthogonal STBCs from CDA.We study the effect of spatial correlation on the BER, and show that the performance loss due to spatial correlation can be alleviated by providing more receive spatial dimensions. We report good BER performance when a training-based iterative decoding/channel estimation is used (instead of assuming perfect channel knowledge) in channels with large coherence times. A comparison of the performances of the PDA algorithm and the likelihood ascent search (LAS) algorithm (reported in our recent work) is also presented.
Performance Bounds for Maximum Likelihood Detection of Single Carrier FDMA (2012)

Single Carrier FDMA (SC-FDMA) plays an important role in modern wireless communications as an alternative to OFDM mainly since it exhibits low peak-to-average power ratio. Accordingly, SC-FDMA is employed as the uplink scheme for the 3GPP long term evolution (LTE). In the presence of multipath, the SC-FDMA signal may arrive at the receiver perturbed by inter-symbol-interference, which renders the single-tap frequency-domain equalization suboptimal. Optimum maximum likelihood detection for SC-FDMA is often prohibitively complex, and hence useful mostly as a performance bound for suboptimal detection schemes. In this work, the optimum-detector performance is analyzed in detail; the analysis can be easily applied to any SC frequency-domain equalization scheme. Closed form bounds on the achievable bit error rate are provided for low and high SNR regimes in correlated and uncorrelated Rayleigh fading channels. The bounds reveal that the diversity order at high SNR is significantly smaller than in the low SNR regime. Moreover, error rate flaring behavior is demonstrated under optimum detection of SC-FDMA. The analytical results are verified by simulations.
Biochemical and Functional Characterization of a Serum-Free rVWF Drug Candidate. (2006)

Abstract Recombinant VWF was co-expressed with recombinant FVIII in CHO cells. In order to obtain fully processed, mature rVWF, rVWF was exposed to recombinant CHO-cell-derived furin for VWF pro-peptide removal. Fermentation for both rVWF and furin and downstream processing were performed under serum-free conditions. Mature rVWF was highly purified by a series of conventional chromatography steps to a purity of &amp;gt; 95%. rVWF was formulated in a protein-free buffer. Several large scale batches of rVWF were produced and characterized in comparison to Humate-P, Wilfactin and a highly purified plasma-derived (pd)VWF, an experimental pd VWF product obtained from cryoprecipitate. Residual pro-VWF levels were approximately 2% of total VWF antigen compared with 0.12, 0.05 and 0.13 for the rVWF product, experimental pd VWF, Humate-P and Wilfactin, respectively. VWF pro-peptide levels were approximately 0.5 pmol per unit VWF antigen, compared with 0.6 and 0.9 for Humate-P and Wilfactin, respectively; in the experimental pd VWF pro-peptide was below the limit of detection. Residual FVIII content was approximately 0.02 units (chromogenic assay) per unit VWF antigen, compared with 0.4 units in Humate-P, and 0.04 units in Wilfactin, and ≤ 0.01 in the experimental pd VWF product. Ristocetin cofactor activity was around 0.7 VWF:RCo units per unit antigen for all rVWF and pd VWF products tested. Collagen-binding activity was also similar between rVWF and pd VWF controls (around 0.8 – 0.9 units per unit). FVIII-binding capacity of rVWF was compared by setting the mean pd VWF as 100% and was found to also be ± 100%. The VWF affinity for FVIII was similar in rVWF and pd VWF (Biacore). rVWF showed high molecular weight multimers in low resolution agarose gels, with a pre-dominance in the high molecular weight range. In contrast to pd VWF, rVWF showed homogenous multimer bands without triplet structure formation due to the non-exposure to ADAMTS13 during the manufacturing process. The pharmacokinetic properties of rVWF were compared with pd VWF in VWF knock-out mice. The half-life or rVWF in VWD mice was 4.3 and 3.5 hours for 2 batches investigated, which seems longer than the half-lives obtained for pd VWF, 2.9 hours for Humate-P and 2.2 hours for a highly purified pd VWF control. Both VWF preparations stabilized endogenous murine FVIII which rose over time to the levels observed in normal C57BI/6J mice. Overall, these results showed that the properties of mature, furin-processed rVWF in vitro and in vivo are equivalent to those of plasma-derived VWF.
Multiscale Modeling of Hepatitis B Virus Capsid Assembly and Its Dimorphism (2022)

Hepatitis B virus (HBV) is an endemic, chronic virus that leads to 800000 deaths per year. Central to the HBV lifecycle, the viral core has a protein capsid assembled from many copies of a single protein. The capsid protein adopts different (quasi-equivalent) conformations to form icosahedral capsids containing 180 or 240 proteins: <i>T</i> = 3 or <i>T</i> = 4, respectively, in Caspar-Klug nomenclature. HBV capsid assembly has become an important target for recently developed antivirals; nonetheless, the assembly pathways and mechanisms that control HBV dimorphism remain unclear. We describe computer simulations of the HBV assembly, using a coarse-grained model that has parameters learned from all-atom molecular dynamics simulations of a complete HBV capsid and yet is computationally tractable. Dynamical simulations with the resulting model reproduce experimental observations of HBV assembly pathways and products. By constructing Markov state models and employing transition path theory, we identify pathways leading to <i>T</i> = 3, <i>T</i> = 4, and other experimentally observed capsid morphologies. The analysis shows that capsid polymorphism is promoted by the low HBV capsid bending modulus, where the key factors controlling polymorphism are the conformational energy landscape and protein-protein binding affinities.
The State of HSTS Deployment: A Survey and Common Pitfalls (2014)

HSTS (HTTP Strict Transport Security) has gained signicant browser and server adoption since reaching IETF proposed status. However, there are several important deployment challenges. A scan of top websites reveals that many HSTS sites have not properly congured the HSTS header, which still leaves them open to some attacks HSTS is meant to solve. We survey the current state of deployment and describe common mistakes and diculties with HSTS conguration. We conclude with approaches for properly deploying HSTS as eectively as possible.
Visible‐Light‐Triggered Molecular Photoswitch Based on Reversible E/Z Isomerization of a 1,2‐Dicyanoethene Derivative (2015)

A designed bis(dithienyl) dicyanoethene-based, strictly E/Z photoswitch (4TCE) operates through state-selective (E and Z isomer) photoactivation with visible light. The E and Z isomers of 4TCE exhibit remarkably different spectroscopic characteristics, including a large separation (70 nm) in their absorption maxima (λ(max)) and a 2.5-fold increase in molar extinction coefficient from cis to trans. The energetically stable trans form can be completely converted to the cis form within minutes when exposed to white light, whereas the reverse isomerization occurs readily upon irradiation by blue light (λ<480 nm) or completely by thermal conversion at elevated temperatures. These features together with excellent thermal stability and photostability of both isomers make this new E/Z photoswitch a promising building block for photoswitchable materials that operate without the need for UV light.
CPLink: Interference-Free Reuse of Cyclic-Prefix Intervals in OFDM-Based Networks (2018)

In this paper, we propose a method to reuse the cyclic-prefix (CP) intervals of an ongoing OFDM link, by another link, without degrading the OFDM link performance. We label the link that reuses the CP-intervals as CPLink, as they use only the CP-intervals of the ongoing link labeled, MainLink. We leverage the fact that the most commonly used OFDM receivers discard the samples in CP-intervals to design the CPLink that ensures below-noise-floor interference at every MainLink-receiver. The key contribution in this paper is the design and study of zero-knowledge CPLink, in which the CPLink-transmitter ensures below-noise-floor interference at every MainLink-receiver with no knowledge about the locations or the number of MainLink-receivers. We analytically show that the zero-knowledge CPLink capacity is positive. For LTE frame structure with 20-MHz bandwidth and 2-km cell-radius, we evaluate the CPLink for two kinds of CPLink-receivers: full-duplex base-station and a half-duplex device. Even for the cell-edge CPLink-transmitters, full-duplex zero-knowledge CPLink data rates can be up to 20 Mbps (60 Mbps) when the CP duration is ~7% (25%) of the data-symbol duration. The half-duplex CPLink rate is 5-40 Mbps when the CPLink-transmitter is within 250 m of CPLink-receiver. CPLink capacity is found to increase near-linearly with the CP duration, thus mitigating CP overhead.
A Platform for Automating Chaos Experiments (2016)

The Netflix video streaming system is composed of many interacting services. In such a large system, failures in individual services are not uncommon. This paper describes the Chaos Automation Platform, a system for running failure injection experiments on the production system to verify that failures in non-critical services do not result in system outages.
Assembly of a Micro Ball-Bearing using a Capillary Gripper and a Microcomponent Feeder (2008)

Assembly of microsystems is still a challenge today. The numerous parasitic forces often make the manipulation behaviour unpredictable, hence difficult to automate. Therefore special designs of grippers and adequate strategies have to be implemented. Recent works have shown that capillary forces are strong enough to be used to manipulate components in microassembly technology []. However, many investigations need to be performed concerning the manufacturing of a microgripper for an industrial use. If the feasibility has been theoretically shown, there is still work to be achieved over the practical implementation of such a gripper.
Design and verification of a compact variable stiffness actuator with a very large range of stiffness (2014)

Current conventional robots require high stiffness joints to provide absolute positioning accuracy in free space which also causes problems when operating in constrained space. To circumvent these problems, Variable Stiffness Actuators (VSAs) can be used to vary their stiffness to suit the task being performed. A new VSA was designed to provide a very large range of stiffness in a compact size. The Arched Flexure VSA uses a cantilevered beam acting as the flexure with a variable point of contact. It allows the joint to have continuous variable stiffness, have zero stiffness for a small range of motion, and rapid stiffness change. Finite element analysis was used to evaluate flexure stiffness. The flexure geometry was optimized for two different objectives. In the first case, the flexure was optimized for maximum stiffness range. This optimization resulted in a stiffness ratio of 1200. In the second case, the flexure was optimized for both maximum stiffness range and constant relative sensitivity. This optimization resulted in a stiffness ratio of 100. A small proof-of-concept VSA actuator based on the constant relative sensitivity alternative was designed, built, and tested. The VSA provided a stiffness ratio of 55, a little more than half of that expected for the flexure alone. The VSA weighed 1.45 pounds and fits within a 4.5 inch by 2 inch by 5 inch volume. The VSA provides the anticipated free joint range for zero stiffness and provides 360 degrees of rotation. It changes from minimum to maximum stiffness in 0.12 seconds.
Scaling Laws for Infrastructure Single and Multihop Wireless Networks in Wideband Regimes (2016)

With millimeter wave bands emerging as a strong candidate for 5G cellular networks, next-generation systems may be in a unique position where spectrum is plentiful. To assess the potential value of this spectrum, this paper derives scaling laws on the per mobile downlink feasible rate with large bandwidth and number of nodes, for both Infrastructure Single Hop (ISH) and Infrastructure Multi-Hop (IMH) architectures. It is shown that, for both cases, there exist critical bandwidth scalings above which increasing the bandwidth no longer increases the feasible rate per node. These critical thresholds coincide exactly with the bandwidths where, for each architecture, the network transitions from being degrees-of-freedom-limited to power-limited. For ISH, this critical bandwidth threshold is lower than IMH when the number of users per base station grows with network size. This result suggests that multi-hop transmissions may be necessary to fully exploit large bandwidth degrees of freedom in deployments with growing number of users per cell.
<title>Characterization and switching study of an optically controlled GaAs switch</title> (1991)

The excitation of persistent photoconductivity followed by photoquenching has been demonstrated in copper-compensated silicon-doped semi-insulating GaAs (GaAs:Si:Cu). These processes allow a switch to be developed which can be closed by the application of one laser pulse ()1064 nm) and opened by the application of a second laser pulse (A21OO nm). In order to further understand the operation of such a switch the dark current-voltage (I-V) characteristics of a switch based on the GaAs:Si:Cu material are investigated using both dc and pulsed electric fields. Experimental studies are also performed on the closing phase of the switch using a 0-switched Nd:YAG laser. In these studies the transition from persistent photoconductivity to non-ohmic current transport is illustrated.
Changes in thermotolerance and Hsp70 expression with domestication in Drosophila melanogaster (2001)

To examine how the duration of laboratory domestication may affect Drosophila stocks used in studies of thermotolerance, we measured expression of the inducible heat-shock protein Hsp70 and survival after heat shock in D. melanogaster strains recently collected from nature and maintained in laboratory culture for up to 50 or more generations. After an initial increase in both Hsp70 expression and thermotolerance immediately after transfer to laboratory medium, both traits remained fairly constant over time and variation among strains persisted through laboratory domestication. Furthermore, variation in heat tolerance and Hsp70 expression did not correlate with the length of time populations evolved in the laboratory. Therefore, while environmental variation likely contributed most to early shifts in strain tolerance and Hsp70 expression, other population parameters, for example genetic drift, inbreeding, and selection likely affected these traits little. As long as populations are maintained with large numbers of individuals, the culture of insects in the laboratory may have little effect on the tolerance of different strains to thermal stress.
Supporting Service Quality Assurance via Trouble Management (2000)

The open service market encourages competition between service providers.To attract and keep customers, service providers require — amongst other things — better tools and techniques to increase their competitiveness. In this paper we address one area for tool support: namely, tools for the support of service quality assurance, i.e. so that checks can be made to ensure that services (and the networks they operate over) fulfil the expectations of customers who have subscribed to them. To demonstrate this, we show how trouble management techniques can be applied to develop generic and reusable components. The test-bed for this work is based on a TINA platform Y.TSP that has been extended with a trouble management component. We show how this trouble management component can be used to support service quality assurance via two application cases studies.