gebhart/patrepeval huggingface dataset:
A new electrochemical method that mimics phosphorylation of the core tau peptide K18 enables kinetic and structural analysis of intermediates and assembly (2023)

Tau protein's reversible assembly and binding of microtubules in brain neurons are regulated by charge-neutralizing phosphorylation, while its hyperphosphorylation drives the irreversible formation of cytotoxic filaments associated with neurodegenerative diseases. However, the structural changes that facilitate these diverse functions are unclear. Here, we analyzed K18, a core peptide of tau, using newly developed spectroelectrochemical instrumentation that enables electroreduction as a surrogate for charge neutralization by phosphorylation, with simultaneous, real-time quantitative analyses of the resulting conformational transitions and assembly. We observed a tipping point between behaviors that paralleled the transition between tau's physiologically required, reversible folding and assembly and the irreversibility of assemblies. The resulting rapidly electroassembled structures represent the first fibrillar tangles of K18 that have been formed in vitro at room temperature without using heparin or other charge-complementary anionic partners. These methods make it possible to (i) trigger and analyze in real time the early stages of conformational transitions and assembly without the need for preformed seeds, heterogenous coacervation, or crowding; (ii) kinetically resolve and potentially isolate never-before-seen early intermediates in these processes; and (iii) develop assays for additional factors and mechanisms that can direct the trajectory of assembly from physiologically benign and reversible to potentially pathological and irreversible structures. We anticipate wide applicability of these methods to other amyloidogenic systems and beyond.
A heteronuclear vinylacetylide cluster as a precursor to allenylidene and metallacyclopentadienyl cluster compounds. X-ray structures of Cp*WRe2(CO)8(.mu.-OMe)(C:C:CMe2) and Cp*WRe2(CO)7(.mu.-H)(CHCHCMeCH) (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA heteronuclear vinylacetylide cluster as a precursor to allenylidene and metallacyclopentadienyl cluster compounds. X-ray structures of Cp*WRe2(CO)8(.mu.-OMe)(C:C:CMe2) and Cp*WRe2(CO)7(.mu.-H)(CHCHCMeCH)Puu Shum Cheng, Yun Chi, Shie Ming Peng, and Gene Hsiang LeeCite this: Organometallics 1993, 12, 2, 250–252Publication Date (Print):February 1, 1993Publication History Published online1 May 2002Published inissue 1 February 1993https://pubs.acs.org/doi/10.1021/om00026a003https://doi.org/10.1021/om00026a003research-articleACS PublicationsRequest reuse permissionsArticle Views41Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Geometry and Structure of Multimaterial Photodetecting Fibers: a Comparative Study (2007)

We report on the influence of geometrical and structural changes on the performance of one dimensional distributed photodetecting fibers for applications in large area optoelectronic systems, remote sensing of analytes and functional fabrics.
Analytical Approach for Enhancement of nMOSFET Performance with Si:C Source/Drain Formed by Molecular Carbon Ion Implantation and Laser Annealing (2010)

2010 International Conference on Solid State Devices and Materials,Analytical Approach for Enhancement of nMOSFET Performance with Si:C Source/Drain Formed by Molecular Carbon Ion Implantation and Laser Annealing
Beyond the Scales: A physics-informed machine learning approach for more efficient modeling of SARS-CoV-2 spike glycoprotein (2021)

Abstract This paper presents a physics-informed machine learning approach to the derivation of a bottom-up coarse-grained model of the SARS-CoV-2 spike glycoprotein from all-atomic molecular dynamics simulations. The machine learning procedure employs a force-matching scheme in the optimization of interaction parameters, where the force-matching scheme is combined in methodology with the initialization of the interaction parameters by the traditional iterative Boltzmann inversion method. The force-matched machine learning procedure is constructed based on two physics-informed layers: one is the Harmonic layer consisting of bond, angle, and dihedral terms as bonded potentials; the other is the Lennard-Jones layer consisting of the non-bonded Lennard-Jones potential. Coarse-grained validation simulations are performed with the learned parameters to test the derived bottom-up coarse-grained model. The simulations are able to reach the microsecond time scale with stability. The physics-informed learning approach yields simulation speeds nearly 40,000 times faster than conventional all-atomic simulations while maintaining comparable simulation accuracy. Additionally, through examination of the non-bonded Lennard-Jones parameters and the radial distribution function analysis, the learning approach matches pairwise distances of the ground-truth data with greater accuracy than the conventional iterative approach method.
Lamps (2010)

Abstract The article contains sections titled: 1. Introduction 2. Light Generation 2.1. Thermal Radiation from Solids 2.2. Radiation from Gas Discharges 2.3. Radiation from Semiconductors (LEDs) 2.4. Modeling of Lamps 3. Main Types of Lamps 4. Lamp Chemistry 4.1. General 4.2. Transport Chemistry 4.2.1. Principles 4.2.2. Incandescent Lamps 4.2.3. Halogen Incandescent Lamps 4.2.4. Metal Halide Lamps 5. Basic Lamp Materials 5.1. Metals 5.2. Glass 5.2.1. Glass Composition and Glass Types 5.2.2. Properties 5.2.3. Glasses for Lamp Types 5.2.4. Glass‐to‐Metal Seals 5.3. Polycrystalline Alumina 5.4. Fluorescent Powders 6. Special Lamp Materials 6.1. Getters 6.2. Amalgams 6.3. Emitters 6.4. Cements and Marking Paints 7. Coatings
Direct observation of lateral current spreading in actively-driven ridge-waveguide lasers (2003)

We report results of two-dimensional local voltage measurement of the transverse cross-section of operating multi-quantum-well ridge-waveguide lasers. We observe lateral non-uniformity of local voltage in the n-cladding layers of the laser and attribute the voltage variation to two-dimensional carrier transport effect within the lasers.
Supplemental Figure S5 from Guidance Molecule SEMA3A Restricts Tumor Growth by Differentially Regulating the Proliferation of Tumor-Associated Macrophages (2023)

&lt;p&gt;SEMA3A DOES NOT REGULATE THE GENE SIGNATURE IN M0-, M1- OR M2-EDUCATED BMDMS.&lt;/p&gt;
Supplementary Figure 1 from A Placenta-Specific Gene Ectopically Activated in Many Human Cancers Is Essentially Involved in Malignant Cell Processes (2023)

Supplementary Figure 1 from A Placenta-Specific Gene Ectopically Activated in Many Human Cancers Is Essentially Involved in Malignant Cell Processes
Influences of microstructure on hydrogen sulfide sensing characteristics of tin dioxide films (1996)

アルミナ基板上に製膜方法の異なる 3 種類の SnO2膜 (厚膜印刷法で作製した厚膜素子,スパッタ法で作製したスパッタ薄膜素子,ゾルーゲル法で作製したゾル基薄膜素子)を作製し, H2S に対するセンサー応答と膜の微細構造との関係について検討した。H2S に対するセソサーの応答性は SnO2 膜中の細孔の状態に強く依存することがわかった。厚膜素子とスパッタ薄膜素子では膜中に微細なミクロ細孔が存在するために,素子温度 200℃ では 5ppm の H2S に対して非常に遅い応答特性を示した。一方,ゾル基薄膜素子では膜中に 10～20 nm の均一なメソ細孔だけが存在し,ミクロ細孔を含まないために, 200℃ でも 5PPm の H2S に対して良好な応答特性を示した。さらに,ゾル基薄膜素子の応答性は H2S 濃度の影響を受けることがわかった。高濃度領域( 5ppm 以上)と低濃度領域( 100ppb 以下)では,良好な応答性を示し,中濃度領域(100ppb ～ 5ppm)では応答が遅くなった。このような応答速度の濃度依存性は,メソ細孔内のガス拡散抵抗の影響によるものであると考えられた。
End-to-end experiment management in HPC (2010)

Experiment management in any domain is challenging. There is a perpetual feedback loop cycling through planning, execution, measurement, and analysis. The lifetime of a particular experiment can be limited to a single cycle although many require myriad more cycles before definite results can be obtained. Within each cycle, a large number of subexperiments may be executed in order to measure the effects of one or more independent variables. Experiment management in high performance computing (HPC) follows this general pattern but also has three unique characteristics. One, computational science applications running on large supercomputers must deal with frequent platform failures which can interrupt, perturb, or terminate running experiments. Two, these applications typically integrate in parallel using MPI as their communication medium. Three, there is typically a scheduling system (e.g. Condor, Moab, SGE, etc.) acting as a gate-keeper for the HPC resources. In this paper, we introduce LANL Experiment Management (LEM), an experimental management framework simplifying all four phases of experiment management. LEM simplifies experiment planning by allowing the user to describe their experimental goals without having to fully construct the individual parameters for each task. To simplify execution, LEM dispatches the subexperiments itself thereby freeing the user from remembering the often arcane methods for interacting with the various scheduling systems. LEM provides transducers for experiments that automatically measure and record important information about each subexperiment; these transducers can easily be extended to collect additional measurements specific to each experiment. Finally, experiment analysis is simplified by providing a general database visualization framework that allows users to quickly and easily interact with their measured data.
Excellent tumor response to pasireotide therapy in an aggressive and dopamine-resistant prolactinoma (2019)

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
Substituent effects on carbon‐13 chemical shifts in 2,6‐disubstituted adamantanes (1981)

Abstract Carbon‐13 NMR spectral data for a series of symmetrical 2,6‐disubstituted adamantanes (O, CH 2 , CH 3 , OH, OCOCH 3 ) are presented. The substituent effects on 13 C chemical shifts are additive, except for carbons 2 and 6 in 2,6‐adamantanedione. The non‐additivity of the substituent effect in the diketone can be interpreted in terms of a through‐space interaction of the carbonyl π‐electrons; the additivity in the other derivatives indicates that there is no appreciable interaction between the substituents.
Visible-light-induced phosgenation of amines by chloroform oxygenation using chlorine dioxide (2022)

We report the visible-light-induced <i>in situ</i> preparation of COCl<sub>2</sub> through the oxygenation of chloroform in the presence of chlorine dioxide, which leads to the safe constructions of carbamoyl chlorides with good-to-high yields and wide substrate scopes. In addition, this method can also be applied to the synthesis of various carbonates.
The Kondo effect in magnetic impurities and ferromagnetic contacts (2011)

Planar macroscopic magnetic tunnel junctions exhibit well defined zero bias anomalies when a thin layer of ferromagnetic CoFe(B) nanodots is inserted within a MgO based tunnel barrier. The conductance curves exhibit a single and a double peak, respectively, for anti-parallel and parallel alignment of the magnetizations of the electrodes which sandwich the tunnel barrier. This leads to a suppression of the tunneling magnetoresistance near zero bias. We show that the double peak structure indicates that the zero-bias anomaly is spin-split due to a magnetic exchange interaction between the magnetic nanodots and the ferromagnetic electrodes. Using a model based on an Anderson quantum dot coupled to ferromagnetic leads, we show that these results imply the coexistence of a Kondo effect and ferromagnetism.
An on-the-fly decoding technique for Reed-Solomon codes (1996)

An on-the-fly error correction technique for double-byte-error-correction (DBEC) and triple-byte-error-detection (TBED) Reed-Solomon (RS) codes is presented in this paper. This new algorithm finds number of byte-errors (single byte-error, double-byte errors, and triple-byte errors) by simply testing the values of a few syndrome functions, and locates and corrects the byte-errors directly without using the standard iterative algorithms for finding the error location polynomial. More importantly, it neither suffers from malfunctions incurred in Deng-Costello algorithm (1987), nor requires syndrome re-calculation as in Koksal-Yucel's modification (1992). It is also much more simpler and faster than the original Deng-Costello algorithm. It has found applications in high-end disk drives where powerful on-the-fly correction is necessary.
Interrelationships between copper deficiency and dietary ascorbic acid in the rabbit (1970)

1. Copper deficiency was induced in growing rabbits and the effects of ascorbic acid supplementation were studied. 2. Signs of Cu deficiency, including reduced growth, achromotrichia and alopecia, anaemia, and gross alterations in the bones of the forelimbs, developed most rapidly in those animals fed ascorbic acid. 3. Microscopic lesions in ossification centres were seen only in bones of rabbits which hadm received the vitamin. 4. Calcium and phosphorus contents of ash from cortical bone were not changed. 5. Compared with the controls, the concentration of liver Cu decreased and that of iron increased (&gt; 50%) in Cu-deficient animals. 6. Cytochrome oxidase activity was reduced in liver and heart in Cu-deficient animals; this effect was accentuated in heart preparations from animals fed ascorbic acid.
ChemInform Abstract: CHEMISTRY OF BORON. 159. (2 + 2) CYCLOADDITIONS OF (TERT‐BUTYLIMINO)(2,2,6,6‐TETRAMETHYLPIPERIDINO)BORANE TO CARBON DICHALCOGENIDES (1985)

Abstract Das Aminoiminoboran (I) addiert die Kohlenstoffdichalkogenide (II) unter Bildung der Azaboretidine (IIIa), (IIIb) (gelb, Röntgenstrukturanalyse: RG P2,2,2,; Z=4) und (IIIc) (zinnoberrot).
Constitutive activation of PRKACA in adrenal Cushing's syndrome (2014)

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
Evaluation of image registration spatial accuracy using a Bayesian hierarchical model (2014)

To evaluate the utility of automated deformable image registration (DIR) algorithms, it is necessary to evaluate both the registration accuracy of the DIR algorithm itself, as well as the registration accuracy of the human readers from whom the "gold standard" is obtained. We propose a Bayesian hierarchical model to evaluate the spatial accuracy of human readers and automatic DIR methods based on multiple image registration data generated by human readers and automatic DIR methods. To fully account for the locations of landmarks in all images, we treat the true locations of landmarks as latent variables and impose a hierarchical structure on the magnitude of registration errors observed across image pairs. DIR registration errors are modeled using Gaussian processes with reference prior densities on prior parameters that determine the associated covariance matrices. We develop a Gibbs sampling algorithm to efficiently fit our models to high-dimensional data, and apply the proposed method to analyze an image dataset obtained from a 4D thoracic CT study.
Analysis of nonmodal glottal event patterns with application to automatic speaker recognition (2008)

Thesis (Ph. D.)--Harvard-MIT Division of Health Sciences and Technology, 2008.
Diagnostic method employing MSH2 nucleic acids (2023)

The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error.sup.+ (RER.sup.+) tumor cells.
Schema Design and Knowledge Discovery (Abstract) (1996)

For investigation of whether the use of a transparent plastic cone (Light-tip) influenced cusp deflection, as compared with a conventional method (control), the following experiments were performed. Mesiodistocclusal (MOD) cavities were prepared in 10 extracted premolars, and stainless steel pins were placed on the cusps. The cavities were bonded with Scotchbond Multipurpose, and the distance between the pins was measured. Control restorations using P-50 were placed in three increments, each increment having been polymerized for 40 s. For placing the test restorations, the Light-tip was fitted to the end of the curing wand and pressed into the resin in the proximal box, and the curing light was turned on. The next increment filled the recess created after the removal of the cone in the resin, and curing was performed with the plastic cone in the occlusal box. The third increment was cured without the cone. Each tooth was used for four restorations. In 16 of 20 cases, a significantly decreased cuspal flexure was found when the cone was used. The flexure decreased 24%, as compared with control.
(Keynote) Low Temperature SmartCutTM Process for 3D Integration (2020)

To support 3D Sequential integration with a cost-effective layer transfer, SmartCut™ process at low temperature (below 500 °C) is proposed. Excellent SOI &amp; BOX layer thickness uniformities are demonstrated, while layer integrity, electron and hole mobility performances are already compliant with development grade requirements.
The Self-Growing Concept – A novel Framework developed by the FP7 CONSERN Project (2011)

The CONSERN project (COoperative aNd Self growing Energy awaRe Networks) develops the novel Self- Growing concept. It is part of the European Commission’s FP7 research initiative focusing on the following two major research directions: i) Solutions for optimised energy and power consumption in
Antioxidant potential and secondary metabolites in Ocimum sanctum L. at various habitats (2013)

In this study, the secondary metabolites and antioxidant property of holy basil (Ocimum sanctum Linn.) Plant at various habitats was compared with those of respective callus cultures induced from each explants in in-vitro. The callus cultures were successfully initiated on Murashige and Skoog (MS) medium supplemented with 2,4-dichlorophenoxy acetic acid (2,4-D) (1 mg/L) combined with different concentrations (0.1 to 1.0 mg/L) of kinetin as plant growth regulators. The distribution of flavonoids and phenolic compounds in the plant extracts were analyzed by using Aluminium (III) chloride colorimetric assay with standards. Flavonoids were found in all callus extracts in comparison with wild plant parts at various habitats. In this study, the antioxidant activity of the extracts was evaluated in vitroantioxidant-testing systems. The secondary metabolites of flavonoid and phenolic acid contents of the O. sanctum were studied in different habitats and in-vitro callus culture extract. Among these studies hills and wet land habit plants showed maximum secondary metabolites than the other habitats. The antioxidant potential was studied by dot blot assay. Among these results, we concluded that, the environmental stress factors such as dryness, temperature, salt and soil pH is an essential factor for release of secondary metabolites antioxidant potent of O. sanctum L.

	 

	Key words: Ocimum sanctum, callus culture, secondary metabolites, antioxidant activity.
Comparison of the thiocarbonyl13C NMR resonances of N‐phenylthioureas, N‐phenyl thiocarbamates and N‐phenyl dithiocarbamates (1986)

Abstract 13 C NMR spectra of N ‐phenylthioureas, N ‐phenyl thiocarbamates and N ‐phenyl dithiocarbamates of the ethyl and n ‐butyl type are compared. Significant differences are observed in the chemical shift of the thiocarbonyl carbon, which do not parallel the electronegativity of the bonded heteroatom.
Catalytic Approaches to Monomers for Polymers Based on Renewables (2019)

Polymers are used in simple consumer items like carpets, furniture, glues, and clothing but are also used in advanced engineering, including materials used in the aerospace industry. Therefore, polymers and consequently their monomers play an important role in our everyday life. Currently, most of the monomers are produced from fossil resources, the supply of which is diminishing. In this paper we review strategies and catalytic processes to obtain currently used and potentially new monomers from renewable bio-based feedstocks and platform chemicals. This Review is divided by type of monomer and includes diacids and esters, diols, hydroxy acids and esters, lactones, carbonates, cyclic ethers, diamines, amino acids and lactams, alkenes, acrylics, and conjugated dienes. Only routes based on the use of homogeneous catalysis, heterogeneous catalysis, or bio-catalysis are described. Fermentative processes are not discussed.
Automated calibration and optical testing of the AWARE-2 gigapixel multiscale camera (2013)

Gigapixel-class cameras present new challenges in calibration, mechanical testing, and optical performance evaluation. The AWARE-2 gigapixel camera has nearly one-hundred micro-cameras covering a 120 degree wide by 40 degree tall field of view, with one pixel spanning an 8 arcsec field angle. Viewing the imagery requires stitching the sub-images together by applying an accurate mapping of registration parameters over the entire field of view. For this purpose, a testbed has been developed to automatically calibrate and test each micro-camera in the array. Using translation stages, rotation stages, and a spatial light modulator for object space, this testbed can project any test scene into a specified micro-camera, building up image quality metrics and a registration look-up table over the entire array.