gebhart/patrepeval huggingface dataset:
Development of A Chimeric Antigen Receptor Targeting C-Type Lectin-Like Molecule-1 for Human Acute Myeloid Leukemia (2017)

The treatment of patients with acute myeloid leukemia (AML) with targeted immunotherapy is challenged by the heterogeneity of the disease and a lack of tumor-exclusive antigens. Conventional immunotherapy targets for AML such as CD33 and CD123 have been proposed as targets for chimeric antigen receptor (CAR)-engineered T-cells (CAR-T-cells), a therapy that has been highly successful in the treatment of B-cell leukemia and lymphoma. However, CD33 and CD123 are present on hematopoietic stem cells, and targeting with CAR-T-cells has the potential to elicit long-term myelosuppression. C-type lectin-like molecule-1 (CLL1 or CLEC12A) is a myeloid lineage antigen that is expressed by malignant cells in more than 90% of AML patients. CLL1 is not expressed by healthy Hematopoietic Stem Cells (HSCs), and is therefore a promising target for CAR-T-cell therapy. Here, we describe the development and optimization of an anti-CLL1 CAR-T-cell with potent activity on both AML cell lines and primary patient-derived AML blasts in vitro while sparing healthy HSCs. Furthermore, in a disseminated mouse xenograft model using the CLL1-positive HL60 cell line, these CAR-T-cells completely eradicated tumor, thus supporting CLL1 as a promising target for CAR-T-cells to treat AML while limiting myelosuppressive toxicity.
The Development of Temporal Resolution: Between-Channel Gap Detection in Infants and Adults (2006)

Unlike within-channel gap detection, the central temporal processing required for between-channel gap detection is still immature at 6 months of age.
ChemInform Abstract: Intermediates for Incorporation of Tetrahydroxypipecolic Acid Analogues of α‐ and β‐D‐Mannopyranose into Combinatorial Libraries: Unexpected Nanomolar‐Range Hexosaminidase Inhibitors. Synthesis of α‐ and β‐Homomannojirimycin. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
APD-Containing Cyclolipodepsipeptides Target Mitochondrial Function in Hypoxic Cancer Cells (2018)

The natural product family of macrocyclic lipodepsipeptides containing the 4-amido-2,4-pentadienoate functionality possesses intriguing cytotoxic selectivity toward hypoxic cancer cells. These subpopulations of cancer cells display increased metastatic potential and resistance to chemo- and radiotherapy. In this paper, we present studies on the mechanism of action of these natural products in hypoxic cancer cells and show that this involves rapid and hypoxia-selective collapse of mitochondrial integrity and function. These events drive a regulated cell death process that potentially could function as a powerful tool in the fight against chemo- and radiotherapy-resistant cancer cells. Toward that end, we demonstrate activity in two different mouse tumor models.
Green GaInN photonic-crystal light-emitting diodes with small surface recombination effect (2011)

We have fabricated green GaInN light-emitting diodes (LEDs) containing two-dimensional photonic crystals (PCs). The PC structure is comprised of air holes that penetrate through the active layer. The observed emission intensity at room temperature was enhanced by a factor of ∼3 when a PC was introduced, which is close to the theoretical enhancement calculated without taking into account surface recombination at the air-hole edges. The carrier lifetime changes little when a PC is incorporated due to the low surface recombination. In contrast, the carrier lifetime in blue-emitting LEDs decreased by a factor of 4 when a PC was introduced. The surface-recombination velocity in green-emitting devices is estimated to be 3×102 cm/s, an order of magnitude smaller than in blue-emitting devices. This is due to the strong carrier localization effect in green-emitting GaInN.
The mild phenotype in severe hemophilia A with Arg1781His mutation is associated with enhanced binding affinity of factor VIII for factor X (2013)

The clinical severity in some patients with haemophilia A appears to be unrelated to the levels of factor (F)VIII activity (FVIII:C), but mechanisms are poorly understood. We have investigated a patient with a FVIII gene mutation at Arg1781 to His (R1781H) presenting with a mild phenotype despite FVIII:C of 0.9 IU/dl. Rotational thromboelastometry using the patient's whole blood demonstrated that the clot time and clot firmness were comparable to those usually observed at FVIII:C 5-10 IU/dl. Thrombin and FXa assays using plasma samples also showed that the peak levels of thrombin formation and the initial rate of FXa generation were comparable to those observed at FVIII:C 5-10 IU/dl. The results suggested a significantly greater haemostatic potential in this individual than in those with severe phenotype. The addition of incremental amounts of FX to control plasma with FVIII:C 0.9 IU/dl in clot waveform analyses suggested that the enhanced functional tenase assembly might have been related to changes in association between FVIII and FX. To further investigate this mechanism, we prepared a stably expressed, recombinant, B-domainless FVIII R1781H mutant. Thrombin generation assays using mixtures of control plasma and FVIII revealed that the coagulation function observed with the R1781H mutant (0.9 IU/dl) was comparable to that seen with wild-type FVIII:C at ~5 IU/dl. In addition, the R1781H mutant demonstrated an ~1.9-fold decrease in Km for FX compared to wild type. These results indicated that relatively enhanced binding affinity of FVIII R1781H for FX appeared to moderate the severity of the haemophilia A phenotype.
Structural analysis of sterically hindered 1,4‐diols from the naturally occurring lignan hydroxymatairesinol a quantum chemical study (2011)

Abstract The structures of TADDOL‐like α‐conidendrin‐based chiral 1,4‐diols (LIGNOLs) have been studied at molecular mechanics, Hartree‐Fock (HF)/6‐31G* and DFT/B3LYP/TZVP level of theory. The molecules included were 1,1‐diphenyl, two diastereomers of 1,1,4‐triphenyl, 1,1,4,4‐tetraphenyl, and 1,1,4,4‐tetramethyl 1,4‐diol. Several conformers of each molecule were studied thorougly also including the entropy contributions. For the triphenyl 1,4‐diols, which can form π − π interactions between phenyl rings, the DFT optimized structures differed significantly from the HF optimized ones. A property for the most stable structures, in addition to the ability to form π − π interactions, seemed to be the possibility to have the aliphatic six‐membered ring in a boat conformation. For all of the studied LIGNOLs some conformers were found, where the two OH groups pointed almost to the same direction. By this an intramolecular hydrogen bond can be formed between them. The bridging hydrogen atom falls at the same place as a chelate‐bonded metal ion would be situated, as in the case of the analogous molecules, TADDOLs, but only a few of these molecules would be able to work well as ligands for asymmetric catalysis. © 2011 Wiley Periodicals, Inc. Int J Quantum Chem, 2011
Supplementary Table S1 from KD5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity <i>in vitro</i> and <i>in vivo</i> (2023)

Supplementary Table S1 from KD5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt;
Evolution of Metastable Structures in Bimetallic Catalysts from Microscopy and Machine-Learning Molecular Dynamics (2020)

Restructuring of interface plays a crucial role in materials science and heterogeneous catalysis. Bimetallic systems, in particular, often adopt very different composition and morphology at surfaces compared to the bulk. For the first time, we reveal a detailed atomistic picture of the long-timescale restructuring of Pd deposited on Ag, using microscopy, spectroscopy, and novel simulation methods. Encapsulation of Pd by Ag always precedes layer-by-layer dissolution of Pd, resulting in significant Ag migration out of the surface and extensive vacancy pits. These metastable structures are of vital catalytic importance, as Ag-encapsulated Pd remains much more accessible to reactants than bulk-dissolved Pd. The underlying mechanisms are uncovered by performing fast and large-scale machine-learning molecular dynamics, followed by our newly developed method for complete characterization of atomic surface restructuring events. Our approach is broadly applicable to other multimetallic systems of interest and enables the previously impractical mechanistic investigation of restructuring dynamics.
ChemInform Abstract: Similarity Measures for Rational Set Selection and Analysis of Combinatorial Libraries: The Diverse Property‐Derived (DPD) Approach. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Suppressing near-receiver scattered waves from seismic land data (2006)

Abstract Upgoing body waves that travel through a heterogeneous near-surface region can excite scattered waves. When the scattering takes place close to the receivers, secondary waves interfere with the upcoming reflections, diminishing the continuity of the wavefront. We estimate a near-surface scattering distribution from a subset of a data record and use this scattering distribution to predict the secondary waves of the entire data record with a wave-theoretical model for near-receiver scattering. We then subtract the predicted scattered waves from the record to obtain the wavefield that would have been measured in the absence of near-surface heterogeneities. We apply this method to part of a field data set acquired in an area with significant near-surface heterogeneity. The main result of our processing scheme is that we effectively remove near-surface scattered waves. This, in turn, increases trace-to-trace coherence of reflection events. Moreover, application of our method improves the results obtained from just an application of a dip filter because we remove parts of the scattered wave with apparent velocities that are typically accepted by the pass zone of the dip filter. Based on these results, we conclude that our method for suppressing near-receiver scattered waves works well on densely sampled land data collected in areas with strong near-surface heterogeneity.
Generation and Characterization of Functional Cardiomyocytes from Rhesus Monkey Embryonic Stem Cells (2006)

Embryonic stem cells (ESCs) from mice and humans (hESCs) have been shown to be able to efficiently differentiate toward cardiomyocytes (CMs). Because murine ESCs and hESCs do not allow for establishment of pre-clinical allogeneic transplantation models, the aim of our study was to generate functional CMs from rhesus monkey ESCs (rESCs). Although formation of ectodermal and neuronal/glial cells appears to be the default pathway of the rESC line R366.4, we were able to change this commitment and to direct generation of endodermal/mesodermal cells and further differentiation toward CMs. Differentiation of rESCs resulted in an average of 18% of spontaneously contracting embryoid bodies (EBs) from rESCs. Semiquantitative reverse transcription-polymerase chain reaction analyses demonstrated expression of marker genes typical for endoderm, mesoderm, cardiac mesoderm, and CMs, including brachyury, goosecoid, Tbx-5, Tbx-20, Mesp1, Nkx2.5, GATA-4, FOG-2, Mlc2a, MLC2v, ANF, and alpha-MHC in rESC-derived CMs. Immunohistological and ultrastructural studies showed expression of CM-typical proteins, including sarcomeric actinin, troponin T, titin, connexin 43, and cross-striated muscle fibrils. Electrophysiological studies by means of multielectrode arrays revealed evidence of functionality, electrical coupling, and beta-adrenergic signaling of the generated CMs. This is the first study demonstrating generation of functional CMs derived from rESCs. In contrast to hESCs, rESCs allow for establishment of pre-clinical allogeneic transplantation models. Moreover, rESC-derived CMs represent a cell source for the development of high-throughput assays for cardiac safety pharmacology.
A network approach to controlling pathogenic inflammation (2013)

Aberrant inflammation appears to be a pathogenic factor in autoimmune diseases and other noxious inflammatory conditions in which the inflammatory process is misapplied, exaggerated, recurrent or chronic. The protein molecules involved in pathogenic inflammation—disease-associated proteins (DAP)—which include chemokines, cytokines, and growth factors and their receptors, appear normal; their networks of interaction are at fault. Here we demonstrate a new approach to network regulation of inflammation based on peptide sequence motifs shared by the second extra-cellular loop (ECL2) of different chemokine receptors; previously known chemokine receptor binding sites have not involved the ECL2 loop. These motifs of 9 amino acids, which we detected by sequence alignment, manifest very low E-values compared with slightly modified sequence variations, indicating that they were not likely to have evolved by chance. To test whether this shared sequence network (SSN) might serve a regulatory function, we synthesized 9-amino acid SSN peptides from the ECL2 loops of three different chemokine receptors. We administered these peptides to rats during the induction of a model of autoimmune arthritis. Two of the peptides significantly downregulated the arthritis; one of the peptides synergized with non-specific anti-inflammatory treatment with dexamethasone. These findings suggest that the SSN peptide motif reported here is likely to have adaptive value in controlling inflammation. Moreover, detection of SSN motif peptides could provide a network-based approach to immune modulation.
The farthest point strategy for progressive image sampling (2002)

A new method of "farthest point strategy" (FPS) for progressive image acquisition is presented. Its main advantage is in retaining its uniformity with the increased density, providing an efficient means for sparse image sampling and display. In contrast to previously presented stochastic approaches, the FPS guarantees the uniformity in a deterministic min-max sense. Within this uniformity criterion, the sampling points are irregularly spaced, exhibiting superior antialiasing properties. A straightforward modification of the FPS yields an image-dependent adaptive sampling scheme. An efficient, O(N log(N)), algorithm for both versions is introduced, and several applications of the FPS are discussed.
Ignition Behavior of alpha-AlH3 (2010)

Abstract : An experimental investigation on the ignition behavior of a-Aluminum Hydride (a-AlH3)has been conducted. The ignition characteristics were determined through the use of two separate modified T-jump experiments. In each experiment, a small amount of material was placed onto a platinum wire, which was heated rapidly through resistive heating. As a result both ignition and hydrogen release temperatures were studied for heating rates ranging from 104 to 105 K/s. The hydrogen release temperature was determined in vacuum, and ignition was studied at ambient pressure in air, CO2, and mixtures of argon with oxygen. Both the hydrogen release and ignition temperature increased as the heating rate increased. Hydrogen release temperatures ranged from approximately 650 to 1200 K, whereas ignition was observed to range from below the melting temperature of aluminum (933 K) to approximately 1500 K. Activation energies for hydrogen release were 27 kJ/mol, and are well below those reported by others at much lower heating rates. This result is consistent with the affects of higher heating rates transitioning the rate-limiting step from one of chemical kinetics to intraparticle hydrogen diffusion. For conditions in which the particles would ignite it was found that the environment did not play a significant role in the ignition temperature, beyond a critical oxygen mole fraction of XO2>0.05. Ensemble average burning times were found to decrease by a factor of about 3 when the oxygen mole fraction was increased from 0.1 to 0.5.
The Design of High Resolution Capacitance Array in SAR ADC (2018)

In SAR ADC, the capacitance array is a very important unit, it will determine the conversion performance in whole ADC. In L-bit SAR ADC, the resolution of the capacitance array must should be larger than L-bit. For getting a smaller layout area, the main body frame of capacitance array uses the M+N bit sectional type, but in traditional design schematic, the least N bit sectional capacitance array' parasitic capacitance will directly reduce the conversion precision. At the same time, the bridging capacitor will be not equal to the unit capacitor. In this improved design, for solving those problems, this paper improves the least N bit sectional capacitor array, letting the bridging capacitor also constituted by unit capacitors, and this capacitance array also can ignore the parasitic capacitors at anywhere. So in this paper, the whole capacitor array all uses the unit capacitors to get the high matching precision performance, at the same time, in this improved design, the parasitic capacitors at the anywhere all could not reduce the conversion resolution of the capacitance array.
Predicting Internal Roughness in Water Mains (1988)

The equations presented provide a quick method for predicting C ‐factors (internal roughness) in unlined metal pipes. The equations are based on the hypothesis that roughness height in such pipes grows approximately linearly over time and are verified with field data from numerous water distribution systems.
Aortic Valve Surgery as an Emergency Procedure (1970)

Twenty-three patients critically ill from aortic valvular disease underwent emergency aortic valve replacement as a life-saving measure. Sixteen patients (70%) survived hospitalization and 14 (61%) are presently living. Of eighteen patients who underwent solitary aortic valve replacement, there were four hospital deaths and two late deaths. Five patients required double valve surgery, with three hospital deaths and no late deaths. The survivors often had dramatic improvement and have done well during an average follow-up period of 9 months. The major factor contributing to mortality after surgery was irreversible myocardial damage particularly evident in patients with longstanding severe valvular disease. Valve replacement can be successfully accomplished in patients critically ill with aortic valve disease, especially if it occurs as an isolated lesion.
Therapeutic approaches in heart failure with preserved ejection fraction: past, present, and future (2020)

Abstract In contrast to the wealth of proven therapies for heart failure with reduced ejection fraction (HFrEF), therapeutic efforts in the past have failed to improve outcomes in heart failure with preserved ejection fraction (HFpEF). Moreover, to this day, diagnosis of HFpEF remains controversial. However, there is growing appreciation that HFpEF represents a heterogeneous syndrome with various phenotypes and comorbidities which are hardly to differentiate solely by LVEF and might benefit from individually tailored approaches. These hypotheses are supported by the recently presented PARAGON-HF trial. Although treatment with LCZ696 did not result in a significantly lower rate of total hospitalizations for heart failure and death from cardiovascular causes among HFpEF patients, subanalyses suggest beneficial effects in female patients and those with an LVEF between 45 and 57%. In the future, prospective randomized trials should focus on dedicated, well-defined subgroups based on various information such as clinical characteristics, biomarker levels, and imaging modalities. These could clarify the role of LCZ696 in selected individuals. Furthermore, sodium-glucose cotransporter-2 inhibitors have just proven efficient in HFrEF patients and are currently also studied in large prospective clinical trials enrolling HFpEF patients. In addition, several novel disease-modifying drugs that pursue different strategies such as targeting cardiac inflammation and fibrosis have delivered preliminary optimistic results and are subject of further research. Moreover, innovative device therapies may enhance management of HFpEF, but need prospective adequately powered clinical trials to confirm safety and efficacy regarding clinical outcomes. This review highlights the past, present, and future therapeutic approaches in HFpEF.
IBN SĪNĀ’S APPROACH TO EQUALITY AND UNITY (2014)

Abstract Aristotle did not develop the quantification of the predicate, but, as shown in a recent paper by Hasnawi, Ibn Sīnā did. In fact, assuming the Aristotelian subject-predicate structure, Ibn Sīnā qualifies those propositions that carry a quantified predicate as deviating ( muḥarrafa ) propositions. A consequence of Ibn Sīnā’s approach is that the second quantification is absorbed by the predicate term. The clear differentiation between a quantified subject, that settles the domain of quantification, and a predicative part, that builds a proposition over this domain, corresponds structurally to the distinction, made in constructive type theory, between the type of sets and the type of propositions. Neither did Aristotle combine his logical analysis of quantification with his ontological theory of relations or equality. But Ibn Sīnā makes use of syllogisms that require a logic of equality, and considered cases where quantification combines via equality with singular terms. Moreover these reflections provide the basis for his theory of numbers that is based on the interplay between the One and the Many . If we combine Ibn Sīnā’s metaphysical theory of equality with his work on the quantification of the predicate, a logic of equality comes out naturally. Indeed, the interaction between quantification of the predicate and equality can be applied to Ibn Sīnā’s own examples of syllogisms involving these notions. By using the formal instruments provided Martin-Löf's constructive type theory, the present paper establishes links between Ibn Sīnā’s metaphysics and his logical work: links that have been discussed in relation to other topics by Thom and Street. Ibn Sīnā did not develop a logic of identity, but he did develop the conceptual means to do so.
Global partial orders from sequential data (2000)

Article Free Access Share on Global partial orders from sequential data Authors: Heikki Mannila Nokia Research Center, PO Box 407, FIN-00045 Nokia Group, Finland Nokia Research Center, PO Box 407, FIN-00045 Nokia Group, FinlandView Profile , Christopher Meek Microsoft Research, One Microsoft Way, Redmond, WA Microsoft Research, One Microsoft Way, Redmond, WAView Profile Authors Info & Claims KDD '00: Proceedings of the sixth ACM SIGKDD international conference on Knowledge discovery and data miningAugust 2000 Pages 161–168https://doi.org/10.1145/347090.347122Online:01 August 2000Publication History 64citation1,113DownloadsMetricsTotal Citations64Total Downloads1,113Last 12 Months25Last 6 weeks7 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF