gebhart/patrepeval huggingface dataset:
Influence of Adsorbates on the Electronic Structure, Bond Strain, and Thermal Properties of an Alumina-Supported Pt Catalyst (2012)

We describe the results of an X-ray absorption spectroscopy (XAS) study of adsorbate and temperature-dependent alterations of the atomic level structure of a prototypical, noble metal hydrogenation and reforming catalyst: ∼1.0 nm Pt clusters supported on gamma alumina (Pt/γ-Al(2)O(3)). This work demonstrates that the metal-metal (M-M) bonding in these small clusters is responsive to the presence of adsorbates, exhibiting pronounced coverage-dependent strains in the clusters' M-M bonding, with concomitant modifications of their electronic structures. Hydrogen and CO adsorbates demonstrate coverage-dependent bonding that leads to relaxation of the M-M bond strains within the clusters. These influences are partially compensated, and variably mediated, by the temperature-dependent electronic perturbations that arise from cluster-support and adsorbate-support interactions. Taken together, the data reveal a strikingly fluxional system with implications for understanding the energetics of catalysis. We estimate that a 9.1 ± 1.1 kJ/mol strain exists for these clusters under H(2) and that this strain increases to 12.8 ± 1.7 kJ/mol under CO. This change in the energy of the particle is in addition to the different heats of adsorption for each gas (64 ± 3 and 126 ± 2 kJ/mol for H(2) and CO, respectively).
Characterizing an Ionic Liquid as a Biological Fixative in Fluorescence Microscopy (2017)

In recent years, light microscopy technology has pushed the envelope to achieve higher temporal, spatial, and spectral resolution These advance techniques have enabled fluorescence microscopy to provide qualitative and quantitative readouts of cellular and molecular phenotypes in fixed and live samples and has transformed cell and molecular data 4, 5 . However, efforts to achieve higher resolution in optical microscopy and realize its full potential are hampered by the obstacle presented by the diffraction limit of light. To overcome this challenge, Correlative Light and Electron Microscopy (CLEM) is being used to combine fluorescence and electron microscopy (EM).
Lack of chemokine receptor CCR1 enhances Th1 responses and glomerular injury during nephrotoxic nephritis (1999)

During the development of nephrotoxic nephritis (NTN) in the mouse, we find that a variety of chemokines and chemokine receptors are induced: CCR1 (RANTES, MIP-1alpha), CCR2 (MCP-1), CCR5 (RANTES, MIP-1alpha, MIP-1beta), CXCR2 (MIP-2), and CXCR3 (IP-10). Their timing of expression indicated that CXCR2 and CCR1 are probably important in the neutrophil-dependent heterologous phase of the disease, whereas CCR1, CCR2, CCR5, and CXCR3 accompany the subsequent mononuclear cell infiltration characteristic of autologous disease. We therefore assessed the role of CCR1 in NTN using CCR1(-/-) mice. We found that neutrophil accumulation in CCR1(-/-) mice was comparable to that in wild-type animals but that renal recruitment of CD4(+) and CD8(+) T cells and macrophages increased significantly. Moreover, CCR1(-/-) mice developed more severe glomerulonephritis than did controls, with greater proteinuria and blood urea nitrogen, as well as a higher frequency of crescent formation. In addition, CCR1(-/-) mice showed enhanced Th1 immune responses, including titers of antigen-specific IgG2a antibody, delayed-type hypersensitivity responses, and production of IFN-gamma and TNF-alpha. Lastly, using recombinant proteins and transfected cells that overexpressed CCR1, we demonstrated that MIP-1alpha, but not RANTES, bound CCR1 and induced cell chemotaxis. Thus, rather than simply promoting leukocyte recruitment during NTN, CCR1 expression profoundly alters the effector phase of glomerulonephritis. Therapeutic targeting of chemokine receptors may, on occasion, exacerbate underlying disease.
Fast switchable electro-optic radial polarization retarder (2008)

A fast and switchable electro-optic radial polarization retarder (EO-RPR) fabricated using the electro-optic ceramic Pb(Mg(1/3)Nb(2/3))O(3)-PbTiO(3) is presented. This EO-RPR is useful for fast and switchable generation of a pure cylindrical vector beam. When used together with a pair of half-wave plates, the EO-RPR can change circularly polarized light into any cylindrical vector beam of interest, such as radially or azimuthally polarized light. Radially and azimuthally polarized light with purities greater than 95% are generated experimentally. The advantages of using EO-RPR include fast response time, low driving voltage, and transparency in a wide spectral range (500 to 7,000 nm).
Kinetics of the Carbon Anode in Molten Salt (2014)

Efficiency in the C/CO 3 2- /O 2 system (725 °C) is related to the distribution of current in the porous anode. Efficiency below 50% results when oxidation occurs within matrix at low local rates, producing CO and CO 2 by a 2-e- net reaction. Efficiency of 75% HHV requires concentration of current on a polarized exterior surface and produces CO 2 product. This picture is supported by segmentation of the I-V curve into two distinct "regimes" separated by an inflection. We present the following model: as applied current is raised, CO 2 accumulates within micropores forming supersaturated levels of CO 2 . This raises the anode potential by 100-250 mV--enough to promote pure CO 2 production. Concentration increases until (1) overall polarization drives CO 2 production to the exterior surface, or, (2) bubbles nucleate and block the pores, shifting the reaction to the accessible exterior. Support for this interpretation is found in suppression of bubble nucleation by surface tension effects leading to high supersaturation; in comparing amplitudes (0.1-0.25 V) of I/V hysteresis loops with the overpotential required for 4 e- pathways; and in the magnitude of limiting current for the porous anode.
Combined forced convection and surface radiation between two parallel plates (2010)

Purpose – This paper's aim is to investigate the effect of surface radiation on the developing laminar forced convection flow of a transparent gas between two vertical parallel plates. The walls are heated asymmetrically, this enhances the effect of radiation even with the two walls having low values of emissivity.
Sulfur as a Novel Nanopatterning Material: An Ultrathin Resist and a Chemically Addressable Template for Nanocrystal Self‐Assembly (2008)

Nanoscale tip-induced polymerization of a sulfur thin film affords a simple negative tone resist that can be used as mask for substrate etching in fluorinated solutions or as a chemical template for the directed self-assembly of gold nanocrystals. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
A 1.2V 110-MHz-UGB differential class-AB amplifier in 65nm CMOS (2014)

A wideband, fully differential, 3-stage class-AB amplifier capable of operation at rates beyond 100 Mbps is described. Common-mode feedback is applied to increase output drive capability and reduce bias-dependent crossover distortion when operating in class-AB from a low supply voltage. Drawing 3.9mA from a nominal V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DD</sub> of 1.2V in 65nm CMOS, the 0.052mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> amplifier delivers 1.6V swing across a 50Ω load with THD+N of 82.6dB at 150kHz in the unity-gain configuration.
A selective synthesis of hydroxyborate anions as novel anchors for zirconocene catalysts (2008)

A new family of hydroxytris(pentafluorophenyl)borate anions [B(C6F5)3OH](-) associated with organic and aprotic cations c+ (imidazolium, pyrrolidinium and phosphonium) has been prepared by a general one-pot synthesis that implies the chloride borate analogues [B(C6F5)3Cl](-)[c]+. The [c]+[B(C6F5)3OH](-) salts have been isolated and fully characterized. The borate anion [B(C6F5)3OH](-) has been shown to protonate the Zr-Me bond in the Cp2ZrMe2 complex forming CH4 and the first published example of anionic [Cp2Zr(Me)OB(C6F5)3](-) species. Standard spectroscopic methods demonstrate the covalent character of the Zr metal center and the anionic character of the boron atom. This protonolysis methodology using [B(C6F5)3OH](-) anion affords a new route for the incorporation of a covalently bonded anionic functionality on organometallic complexes. This provides a new way to immobilize transition metal complexes in ionic liquids.
Stimulation of alpha2-adrenergic receptors impairs influenza virus infection (2018)

Influenza A viruses cause seasonal epidemics and occasional pandemics. The emergence of viruses resistant to neuraminidase (NA) inhibitors and M2 ion channel inhibitors underlines the need for alternate anti-influenza drugs with novel mechanisms of action. Here, we report the discovery of a host factor as a potential target of anti-influenza drugs. By using cell-based virus replication screening of a chemical library and several additional assays, we identified clonidine as a new anti-influenza agent in vitro. We found that clonidine, which is an agonist of the alpha2-adrenergic receptor (α2-AR), has an inhibitory effect on the replication of various influenza virus strains. α2-AR is a Gi-type G protein-coupled receptor that reduces intracellular cyclic AMP (cAMP) levels. In-depth analysis showed that stimulation of α2-ARs leads to impairment of influenza virus replication and that α2-AR agonists inhibit the virus assembly step, likely via a cAMP-mediated pathway. Although clonidine administration did not reduce lung virus titers or prevent body weight loss, it did suppress lung edema and improve survival in a murine lethal infection model. Clonidine may thus protect against lung damage caused by influenza virus infection. Our results identify α2-AR-mediated signaling as a key pathway to exploit in the development of anti-influenza agents.
Single-Round Pattern Matching Key Generation Using Physically Unclonable Function (2019)

Paral and Devadas introduced a simple key generation scheme with a physically unclonable function (PUF) that requires no error correction, e.g., by using a fuzzy extractor. Their scheme, called a pattern matching key generation (PMKG) scheme, is based on pattern matching between auxiliary data, assigned at the enrollment in advance, and a substring of PUF output, to reconstruct a key. The PMKG scheme repeats a round operation, including the pattern matching, to derive a key with high entropy. Later, to enhance the efficiency and security, a circular PMKG (C-PMKG) scheme was proposed. However, multiple round operations in these schemes make them impractical. In this paper, we propose a single-round circular PMKG (SC-PMKG) scheme. Unlike the previous schemes, our scheme invokes the PUF only once. Hence, there is no fear of information leakage by invoking the PUF with the (partially) same input multiple times in different rounds, and, therefore, the security consideration can be simplified. Moreover, we introduce another hash function to generate a check string which ensures the correctness of the key reconstruction. The string enables us not only to defeat manipulation attacks but also to prove the security theoretically. In addition to its simple construction, the SC-PMKG scheme can use a weak PUF like the SRAM-PUF as a building block if our system is properly implemented so that the PUF is directly inaccessible from the outside, and, therefore, it is suitable for tiny devices in the IoT systems. We discuss its security and show its feasibility by simulations and experiments.
Effect of spin state on the redox and electron-transfer properties of the variable-spin family of [FeII(6-Mepy)n(py)3-n)tren](PF6)2 complexes in solution (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of spin state on the redox and electron-transfer properties of the variable-spin family of [FeII(6-Mepy)n(py)3-n)tren](PF6)2 complexes in solutionKarl M. Kadish, Chih Ho Su, D. Schaeper, Connie L. Merrill, and Lon J. WilsonCite this: Inorg. Chem. 1982, 21, 9, 3433–3437Publication Date (Print):September 1, 1982Publication History Published online1 May 2002Published inissue 1 September 1982https://pubs.acs.org/doi/10.1021/ic00139a033https://doi.org/10.1021/ic00139a033research-articleACS PublicationsRequest reuse permissionsArticle Views129Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
University Fisheries Programs in the United States: Structure and Needs (1988)

Abstract A survey of fisheries programs in the United States was undertaken to determine faculty participation, curriculum requirements and their relationship to AFS certification, student enrollment, and graduate research activities. Of 138 programs surveyed, 45 useable questionnaires from programs offering a named fisheries degree (FD) and 35 from programs not offering a named degree (NON-FD) were returned. The predominance of FD programs offering curricula at all degree levels appeared to reflect an overall institutional commitment to fisheries education and research. In contrast, NON-FD fisheries programs usually were specialized areas within biology, zoology, or natural resources departments. Accordingly, the average number of fisheries specialists in NON-FD was lower, and probably resulted in increased emphasis on teaching (at schools with only undergraduate programs) or research (at schools with only graduate programs). Both types of programs emphasized undergraduate courses in biology, chemistry, ...
Matching Vector Codes (2010)

A locally decodable code encodes a message by a codeword, such that even if the codeword is corrupted by noise, each message bit can be recovered with high probability by a randomized decoding procedure that reads only few bits of the codeword. Recently a new class of locally decodable codes, based on families of vectors with restricted dot products has been discovered. We refer to those codes as Matching Vector (MV) codes. In this work we develop a new view of MV codes and uncover certain similarities between them and classical Reed Muller codes. Our view allows us to obtain a deeper insight into the power and limitations of MV codes. We use it to construct codes that can tolerate more errors or are shorter than previously known codes for certain parameter settings. We also show super-linear lower bounds on the codeword length of any MV code.
Thermal Manipulation of Water Droplets - A Path to Droplet Microfluidics (2011)

Optical manipulation of water droplets in an oil matrix is important in the development of droplet microfluidics. In this report we demonstrate infrared laser based droplet manipulation using the thermal Marangoni effect and thermal convection.
Studying page life patterns in dynamical web (2013)

With the ever-increasing speed of content turnover on the web, it is particularly important to understand the patterns that pages' popularity follows. This paper focuses on the dynamical part of the web, i.e. pages that have a limited lifespan and experience a short popularity outburst within it. We classify these pages into five patterns based on how quickly they gain popularity and how quickly they lose it. We study the properties of pages that belong to each pattern and determine content topics that contain disproportionately high fractions of particular patterns. These developments are utilized to create an algorithm that approximates with reasonable accuracy the expected popularity pattern of a web page based on its URL and, if available, prior knowledge about its domain's topics.
Liposomal delivery of photosensitising agents (2005)

Photodynamic therapy is a clinically approved treatment for cancer and noncancer diseases. This modality utilises light-activatable chemicals (photosensitising agents) to capture photons and use light energy for the production of cytotoxic reactive molecular species. Most photosensitisers that are in use clinically or in preclinical development are hydrophobic and tend to aggregate in the aqueous environment, which limits their delivery and photosensitising efficiency. Liposomal delivery of photosensitisers will often overcome or decrease these problems. In addition, as with chemotherapeutic agents, liposomal formulations of photo-sensitising agents may help to achieve better selectivity for tumour tissue compared with normal tissue. Over the past years, liposomal photosensitisers have emerged as therapeutic agents in many experimental studies, and have obtained approval for clinical applications. Recent progress in liposomal technology further opens up the possibility of generating more selectively targeted photosensitisers encapsulated in liposomes. This review will cover progress in the use of liposomal photosensitisers, summarise current liposomal formulations, and project future directions for the liposomal delivery of photosensitising agents.
On Simultaneously Determinizing and Complementing omega-Automata (Extended Abstract) (1989)

We give a construction to simultaneously de- terminize and complement a Buchi Automaton on Infinite strings, with an exponential blowup in states, and linear blowup in number of pairs. An exponential lower bound is already known. The previous best construction was do- uble exponential (Safra 88). This permits exponentially improved essentially optimal decision procedures for vari- ous Modal Logics of Programs. The new construction also gives exponentially improved conversions between various kinds of w-automata.
Strengthening Ethics from the Construction of Socialist Political Civilization (2005)

Strengthening the idea logy of college students is the necessity of Marxism.which is the required by socialist civilization.It has been proved out that to understand the new situations of China could be the way to help the students to improve themselves, although,there were side-effects in the evolution of socialism.And they object to the side-effects.
Infectiousness of pigs infected by the Porcine Reproductive and Respiratory Syndrome virus (PRRSV) is time-dependent (2012)

The time-dependent transmission rate of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) and the correlation between infectiousness, virological parameters and antibody responses of the infected pigs were studied in experimental conditions. Seven successive transmission trials involving a total of 77 specific pathogen-free piglets were carried out from 7 to 63 days post-inoculation (dpi). A semi-quantitative real time RT-PCR was developed to assess the evolution of the viral genome load in blood and nasal swabs from inoculated and contact pigs, with time. Virus genome in blood was detectable in inoculated pigs from 7 to 77 dpi, whereas viral genome shedding was detectable from nasal swabs from 2 to 48 dpi. The infectiousness of inoculated pigs, assessed from the frequency of occurrence of infected pigs in susceptible groups in each contact trial, increased from 7 to 14 dpi and then decreased slowly until 42 dpi (3, 7, 2, 1 and 0 pigs infected at 7, 14, 21, 28 and 42 dpi, respectively). These data were used to model the time-dependent infectiousness by a lognormal-like function with a latency period of 1 day and led to an estimated basic reproduction ratio, R0 of 2.6 [1.8, 3.3]. The evolution of infectiousness was mainly correlated with the time-course of viral genome load in the blood whereas the decrease of infectiousness was strongly related to the increase in total antibodies.
Belinostat, a novel pan-histone deacetylase inhibitor (HDACi), in relapsed or refractory peripheral T-cell lymphoma (R/R PTCL): Results from the BELIEF trial. (2013)

8507 Background: Therapies approved in US for R/R PTCL have overall response rates (ORR) of 25%-27%. The need for new therapies persists. BELIEF is a pivotal, single-arm study of belinostat in patients with R/R PTCL after failure of ≥1 prior systemic therapies. Methods: Entry criteria were measurable PTCL, platelets ≥ 50,000/µL, no prior HDACi therapy, and adequate organ function. PTCL was confirmed by central pathology review (CPRG). Belinostat 30 min IV infusion at 1000 mg/m 2 was administered on days 1–5 of a 3 week cycle until progression or unacceptable toxicity. Tumor response was assessed by Cheson 2007 criteria. The primary endpoint was ORR. Results: Patients with R/R PTCL (N=129, 53% male, median age 63 y) received belinostat a median of 2 cycles (range 1–33). The median number of prior therapies was 2 (1-8) including CHOP/CHOP-like (96%) and stem cell transplant (23%). The median administered dose intensity was 98%. One and two dose reductions of 25% occurred in 12% and 1% of patients, respectively, due to adverse events (AEs). For patients with CPRG confirmed PTCL (N=120), the ORR was 26% (n=31; 10% CR; 16% PR). The median time to response was 5.6 weeks (range 4.3-50.4). The median duration of response (DoR) was 8.3 months; longest DoR was 29.4 months. Seven patients remain on study in response. For the subgroup of patients with CPRG confirmed PTCL and baseline platelets ≥100,000/μL (N=100) ORR was 28% (CR 11%; PR 17%). The most frequent (≥ 5%) grade 3-4 treatment emergent AEs were thrombocytopenia (13%), neutropenia (13%), anemia (10%), dyspnea (6%), pneumonia (6%), and fatigue (5%). Patients with platelets &lt;100K tolerated belinostat, with 98% dose intensity. Belinostat was well tolerated with a low incidence of myelosuppression. Discontinuations were due to PD (64%), death (11%), AEs (7%), patient request (8%), and other (4%). Conclusions: Belinostat demonstrated a 26%-28% ORR in BELIEF and was well tolerated with a favorable safety profile in patients with R/R PTCL including those with low platelets. The low incidence of myelosuppression observed warrants further investigation of belinostat combination therapy to develop new treatment paradigms for R/R PTCL. Clinical trial information: NCT00865969.