gebhart/patrepeval huggingface dataset:
Multimodal registration of SD-OCT volumes and fundus photographs using histograms of oriented gradients (2016)

With availability of different retinal imaging modalities such as fundus photography and spectral domain optical coherence tomography (SD-OCT), having a robust and accurate registration scheme to enable utilization of this complementary information is beneficial. The few existing fundus-OCT registration approaches contain a vessel segmentation step, as the retinal blood vessels are the most dominant structures that are in common between the pair of images. However, errors in the vessel segmentation from either modality may cause corresponding errors in the registration. In this paper, we propose a feature-based registration method for registering fundus photographs and SD-OCT projection images that benefits from vasculature structural information without requiring blood vessel segmentation. In particular, after a preprocessing step, a set of control points (CPs) are identified by looking for the corners in the images. Next, each CP is represented by a feature vector which encodes the local structural information via computing the histograms of oriented gradients (HOG) from the neighborhood of each CP. The best matching CPs are identified by calculating the distance of their corresponding feature vectors. After removing the incorrect matches the best affine transform that registers fundus photographs to SD-OCT projection images is computed using the random sample consensus (RANSAC) method. The proposed method was tested on 44 pairs of fundus and SD-OCT projection images of glaucoma patients and the result showed that the proposed method successfully registers the multimodal images and produced a registration error of 25.34 ± 12.34 <i>μ</i>m (0.84 ± 0.41 pixels).
p53 regulates epithelial–mesenchymal transition through microRNAs targeting ZEB1 and ZEB2 (2011)

p53 suppresses tumor progression and metastasis.Epithelial-mesenchymal transition (EMT) is a key process in tumor progression and metastasis.The transcription factors ZEB1 and ZEB2 promote EMT.Here, we show that p53 suppresses EMT by repressing expression of ZEB1 and ZEB2.By profiling 92 primary hepatocellular carcinomas (HCCs) and 9 HCC cell lines, we found that p53 up-regulates microRNAs (miRNAs), including miR-200 and miR-192 family members.The miR-200 family members transactivated by p53 then repress ZEB1/2 expression.p53-regulated miR-192 family members also repress ZEB2 expression.Inhibition or overexpression of the miRNAs affects p53-regulated EMT by altering ZEB1 and ZEB2 expression.Our findings indicate that p53 can regulate EMT, and that p53regulated miRNAs are critical mediators of p53-regulated EMT.
SU-GG-T-604: GPU-Accelerated KV/MV Dose Computation (2010)

Purpose: To develop a comprehensive GPU-accelerated, superposition/convolution based dose calculation engine supporting both a modern dual-source MV model and an analytical kV source model Method and Materials: An analytical kV source model was developed for use with the Small Animal Research Radiation Project (SARRP), which analytically calculated the fluence to every voxel. The MV source model contains a traditional primary and an enhanced extra-focal algorithm that efficiently accounts for leaf-height effects. The spectral and attenuation effects of static beam modifiers were integrated into each source's spectral function. The total energy released per unit mass (TERMA) computation used back-projection with optional exact multi-spectral attenuation. Superposition/convolution was implemented using the inverse cumulative-cumulative kernel and exact radiological path ray-tracing with optional kernel tilting. Two superposition variants were implemented and benchmarked. Multi-resolution superposition approximates true, solid angle ray-tracing. Arc superposition increases the relative temporal TERMA sampling. Results: The kV source model performance was integrated into the TERMA computation, increasing performance in a volume resolution and collimator size dependent manner. MV source model performance was <9ms (data dependent) for a high resolution (4002) field using an NVIDIA GeForce GTX 280. Our TERMA GPU implementation was improved, doubling performance. Our GPU Superposition implementation was improved by ∼18% to 0.058 s and 1.186 s for 643 and 1283 water phantoms; a speed-up of 80–142x over the highly optimized Pinnacle3 (Philips-Madison, WI) implementation. Pinnacle3 times were 8.3 s and 94 s, respectively, on an AMD Opteron 254 (2 cores, 2.8GHz). Extensive accuracy benchmarks indicated that Arc Superposition increases dose computation efficiency and that Multi-Resolution Superposition slightly under estimates MV intra-patient scatter. Conclusions: We have completed a comprehensive, GPU-accelerated dose engine in order to provide a substantial performance gain over CPU based implementations.
Periampullary and Pancreatic Incidentaloma (2006)

Incidentally discovered periampullary and pancreatic masses comprise a substantial proportion of patients undergoing PD. Roughly three fourths of these lesions are malignant or premalignant, and amenable to curative resection. Resected malignant PIs have favorable pathologic features as compared with resected malignant NIs, and resection of these early lesions in asymptomatic individuals is associated with improved survival, compared with patients with symptomatic disease.
Apatite Formation on a Biomineral Based Dental Filling Material (2006)

This chapter contains sections titled: Introduction Materials and Experimental Results Discussion Conclusions
Remodeling and ingrowth of bone at two years in a canine cementless total hip-arthroplasty model. (1992)

Remodeling and ingrowth of bone in association with the use of uncemented femoral components were examined at two years in a canine total hip-arthroplasty model. Twenty-two dogs received a unilateral uncemented femoral stem that was made of Ti6A14V and was covered with one of three types of titanium porous coating: fiber-metal, beads, or plasma flame-spray. The amount and distribution of ingrowth of bone differed somewhat among the groups at two years, but the patterns of remodeling of bone in the medullary canal and cortex were similar. In general, about 15 to 18 per cent of the cortical bone was lost adjacent to the levels of the stem that were covered with the porous coating. Most of the loss of cortical bone was due to subperiosteal resorption proximally and endosteal resorption at the middle and distal levels of the stem. Increased cortical porosity accounted for only a small fraction of the loss of cortical bone. The amount of medullary bone increased proximally and distally, so that the loss of total bone mass was significantly only at the mid-part of the stem. The amount of loss of cortical bone was similar to that observed in a previous six-month study, suggesting that a steady state was achieved in the present model.
Cationic UV cure kinetics for multifunctional epoxies (2002)

Abstract Two epoxy monomers with widely different functionalities ( f = 2 and f = 8) were selected for the study and comparison of photocuring kinetics, in the presence of two different photoinitiators. It has been observed that for the same photoinitiator, the optimum concentration is lower for the epoxy monomer with a lower functionality. In terms of photoinitiation efficiency, the photoinitiator based on aromatic sulfonium salts has been determined to be a better candidate. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 86: 518–525, 2002
ChemInform Abstract: Supported Aqueous‐Phase Catalysis (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
DEVELOPING AND VALIDATING COVID-19 ADVERSE OUTCOME RISK PREDICTION MODELS FROM A BI-NATIONAL EUROPEAN COHORT OF 5594 PATIENTS (2020)

ABSTRACT Background Patients with severe COVID-19 have overwhelmed healthcare systems worldwide. We hypothesized that Machine Learning (ML) models could be used to predict risks at different stages of management (at diagnosis, hospital admission and ICU admission) and thereby provide insights into drivers and prognostic markers of disease progression and death. Methods From a cohort of approx. 2.6 million citizens in the two regions of Denmark, SARS-CoV-2 PCR tests were performed on subjects suspected for COVID-19 disease; 3944 cases had at least one positive test and were subjected to further analysis. A cohort of SARS- CoV-2 positive cases from the United Kingdom Biobank was used for external validation. Findings The ML models predicted the risk of death (Receiver Operation Characteristics – Area Under the Curve, ROC-AUC) of 0.904 at diagnosis, 0.818, at hospital admission and 0.723 at Intensive Care Unit (ICU) admission. Similar metrics were achieved for predicted risks of hospital and ICU admission and use of mechanical ventilation. We identified some common risk factors, including age, body mass index (BMI) and hypertension as driving factors, although the top risk features shifted towards markers of shock and organ dysfunction in ICU patients. The external validation indicated fair predictive performance for mortality prediction, but suboptimal performance for predicting ICU admission. Interpretation ML may be used to identify drivers of progression to more severe disease and for prognostication patients in patients with COVID-19. Prognostic features included age, BMI and hypertension, although markers of shock and organ dysfunction became more important in more severe cases. We provide access to an online risk calculator based on these findings. Funding The study was funded by grants from the Novo Nordisk Foundation to MS (#NNF20SA0062879 and #NNF19OC0055183) and MN (#NNF20SA0062879). The foundation took no part in project design, data handling and manuscript preparation.
Choosing the content of textual summaries of large time-series data sets (2006)

Natural Language Generation (NLG) can be used to generate textual summaries of numeric data sets. In this paper we develop an architecture for generating short (a few sentences) summaries of large (100KB or more) time-series data sets. The architecture integrates pattern recognition, pattern abstraction, selection of the most significant patterns, microplanning (especially aggregation), and realisation. We also describe and evaluate SumTime-Turbine, a prototype system which uses this architecture to generate textualsummaries of sensor data from gas turbines.
Increased expression and activity of group IIA and X secretory phospholipase A2 in peritumoral versus central colon carcinoma tissue. (2007)

Secretory phospholipase A2 (sPLA2) type IIA and X was analyzed in tumors from 22 patients with colon adenocarcinomas in order to determine the involvement and activity of sPLA2 in colon cancer. Evaluation of immunoreactive sPLA2 IIA by Western blotting showed a significantly higher level in the periphery of the tumors, compared to central tumor regions. Increased levels of sPLA2 IIA protein correlated with a two-fold increase in sPLA2 enzymatic activity in the peripheral regions compared to central regions. Nineteen out of 22 tumors showed high levels of sPLA2 IIA, whereas 7 out of the 22 tumors showed sPLA2 type X. These data demonstrate that both sPLA2 type IIA and X are present in human colon cancer and suggest a role for sPLA2 in colon cancer tumor immunology and tumorigenesis.
Transformation of monoamine oxidase-B primary amine substrates into time-dependent inhibitors. Tertiary amine homologs of primary amine substrates (1993)

A family of N-methylated and N,N-dimethylated alkyl and arylalkylamines was prepared and more than half of the analogues were shown to be time-dependent pseudo-first-order inhibitors of monoamine oxidase-B. Some of the time-dependent inactivators were reversible and others were irreversible with respect to prolonged dialysis following inactivation. Partition ratios ranged from zero to 11,000. These results are rationalized in terms of a combination of an inductive effect and a stereoelectronic effect as a result of hindered rotation of an active site covalent adduct. A molecular mechanics calculation indicates that there is at least 10 kcal/mol of torsional energy to be overcome in order for the enzyme adduct to be released. These findings show that tertiary amine homologues of primary amine substrates of monoamine oxidase are time-dependent inhibitors, and this should be useful in the design of new inactivators of this enzyme.
Claudin‐1, Claudin‐2 and Claudin‐11 Genes Differentially Associate with Distinct Types of Anti‐inflammatory Macrophages In vitro and with Parasite‐ and Tumour‐elicited Macrophages In vivo (2012)

Macrophages altered by various Th2-associated and anti-inflammatory mediators--including IL-4 and IL-13 [inducing alternatively activated macrophages (AAMs)], IL-10 and TGF-β--were generically termed M2. However, markers that discriminate between AAMs and other M2 remain scarce. We previously described E-cadherin as a marker for AAMs, permitting these macrophages to fuse upon IL-4 stimulation. To identify novel potential contributors to macrophage fusion, we assessed the effect of IL-4 on other adherens and tight junction-associated components. We observed an induction of claudin-1 (Cldn1), Cldn2 and Cldn11 genes by IL-4 in different mouse macrophage populations. Extending our findings to other stimuli revealed Cldn1 as a mainly TGF-β-induced gene and showed that Cldn11 is predominantly associated with IL-4-induced AAMs. Cldn2 is upregulated by diverse stimuli and is not associated with a specific macrophage activation state in vitro. Interestingly, different claudin genes preferentially associate with M2 from distinct diseases. While Cldn11 is predominantly expressed in AAMs from helminth-infected mice, Cldn1 is the major macrophage claudin during chronic trypanosomiasis and Cldn2 dominates in tumour-associated macrophages. Overall, we identified Cldn1, Cldn2 and Cldn11 as genes that discriminate between diverse types of M2.
Function and Characterization of Metal Oxide−Nafion Composite Membranes for Elevated-Temperature H2/O2 PEM Fuel Cells (2006)

Metal-oxide-recast Nafion composite membranes were studied for operation in hydrogen/oxygen proton-exchange membrane fuel cells (PEMFC) from 80 to 130 °C and at relative humidities ranging from 75 to 100%. Membranes of nominal 125 μm thickness were prepared by suspending a variety of metal oxide particles (SiO2, TiO2, Al2O3, and ZrO2) in solubilized Nafion. The composite membranes were characterized using electrochemical, X-ray scattering, spectroscopic, mechanical, and thermal analysis techniques. Membrane characteristics were compared to fuel cell performance. These studies indicated a specific chemical interaction between polymer sulfonate groups and the metal oxide surface for systems that provide a good elevated-temperature (i.e., fuel-cell operation above 120 °C) performance. Composite systems that incorporate either a TiO2 or a SiO2 phase produced superior elevated-temperature, low-humidity behavior compared to that of a simple Nafion-based fuel cell. Improved temperature tolerance permits the introduction of at least 500 ppm CO contaminant in the H2 fuel stream without cell failure, in contrast to standard Nafion-based cells, which fail below 50 ppm of carbon monoxide.
Enantioselective Ring Opening of Epoxides with Silicon Tetrachloride in the Presence of a Chiral Lewis Base (1998)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTEnantioselective Ring Opening of Epoxides with Silicon Tetrachloride in the Presence of a Chiral Lewis BaseScott E. Denmark, Paul A. Barsanti, Ken-Tsung Wong, and Robert A. StavengerView Author Information Roger Adams Laboratory, Department of Chemistry, University of Illinois, Urbana, Illinois 61801 Cite this: J. Org. Chem. 1998, 63, 8, 2428–2429Publication Date (Web):March 19, 1998Publication History Received29 January 1998Published online19 March 1998Published inissue 1 April 1998https://doi.org/10.1021/jo9801420Copyright © 1998 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views2990Altmetric-Citations153LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (36 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Anions,Ethers,Ions,Oxides,Ring opening reactions Get e-Alerts
Linear dependence of surface drag on surface viscosity (2004)

Flow at an air-water interface is limited by drag from both the two-dimensional surface and three-dimensional subphase. Separating these contributions to the interfacial drag is necessary to measure surface viscosity as well as to understand the influence of the interface on flow. In these experiments, a magnetic needle floating on a monolayer-covered air-water interface is put in motion by applying a constant magnetic force, F(m). The needle velocity varies exponentially with time, reaching a terminal velocity F(m)/C, in which C is the drag coefficient. C is shown to be linearly proportional to the monolayer surface viscosity, eta(s), for dipalmitoylphosphatidylcholine monolayers in the condensed phase by comparison to surface viscosity measured by channel viscometry.
Wall Roughness Effects on Stagnation-Point Heat Transfer Beneath an Impinging Liquid Jet (1994)

Jet impingement cooling applications often involve rough surfaces, yet few studies have examined the role of wall roughness. Surface protrusions can pierce the thermal sublayer in the stagnation region and increase the heat transfer. In this paper, the effect of surface roughness on the stagnation-point heat transfer of an impinging unsubmerged liquid jet is investigated. Experiments were performed in which a fully developed turbulent water jet struck a uniformly heated rough surface. Heat transfer measurements were made for jets of diameters 4.4–9.0 mm over a Reynolds number range of 20,000–84,000. The Prandtl number was held nearly constant at 8.2–9.1. Results are presented for nine well-characterized rough surfaces with root-mean-square average roughness heights ranging from 4.7 to 28.2 μm. Measured values of the local Nusselt number for the rough plates are compared with those for a smooth wall, and increases of as much as 50 percent are observed. Heat transfer in the stagnation zone is scaled with Reynolds number and a roughness parameter. For a given roughness height and jet diameter, the minimum Reynolds number required to increase heat transfer above that of a smooth plate is established. A correlation for smooth wall heat transfer is also given.
Polypill Eligibility for Patients with Heart Failure with Reduced Ejection Fraction in the ASIAN-HF Registry: A Cross-Sectional Analysis (2023)

The majority of patients with HFrEF in ASIAN-HF were eligible for a HFrEF polypill and were not receiving conventional triple therapy. HFrEF polypills may be a feasible and scalable implementation strategy to help close the treatment gap among patients with HFrEF in Asia.
Stochastic Dynamics of a Layered Neural Network; Exact Solution (1987)

We extend our previous solution of a network with deterministic parallel dynamics to stochastic dynamics. Stochasticity is controlled by a "temperature" variable. An exact solution for the dynamics of the network at any temperature is presented. A region of good recall is found, separated from a region of no recall by a first-order line terminating at a critical point. The exact time-evolution of mixtures of patterns is given as well.
Transfer of Drug Resistance Genes into Hematopoietic Stem Cells for Marrow Protection (2008)

Abstract The study investigates the use of gene transfer with genes that confer drug resistance for the purpose of bone marrow protection from chemotherapy.
ChemInform Abstract: Detection of Morphine in ppb Range by Using SPR (Surface‐Plasmon‐ Resonance) Immunosensor. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The Reemergence of Chemistry for Post-Graphene Two-Dimensional Nanomaterials (2015)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTThe Reemergence of Chemistry for Post-Graphene Two-Dimensional NanomaterialsMark C. HersamCite this: ACS Nano 2015, 9, 5, 4661–4663Publication Date (Web):May 26, 2015Publication History Published online26 May 2015Published inissue 26 May 2015https://pubs.acs.org/doi/10.1021/acsnano.5b02806https://doi.org/10.1021/acsnano.5b02806editorialACS PublicationsCopyright © 2015 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views3077Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (2 MB) Get e-AlertscloseSUBJECTS:Mathematical methods,Nanomaterials,Phosphorus,Silicon,Two dimensional materials Get e-Alerts
Orientation of Lamellar Nanostructures in the Patterned Thin Films of a Diblock Copolymer (2008)

The authors thank the Korea Science and Engineering Foundation (KOSEF) through the NANO Systems Institute-National Core Research Center (NSI-NCRC) Program for financial support.
Determination of the Sign of the Decay Width Difference in theBs0System (2012)

The interference between the K+ K- S-wave and P-wave amplitudes in B(s)(0) → J/ψK+ K- decays with the K+ K- pairs in the region around the ϕ(1020) resonance is used to determine the variation of the difference of the strong phase between these amplitudes as a function of K+ K- invariant mass. Combined with the results from our CP asymmetry measurement in B(s)(0) → J/ψϕ decays, we conclude that the B(s)(0) mass eigenstate that is almost CP = +1 is lighter and decays faster than the mass eigenstate that is almost CP = -1. This determines the sign of the decay width difference ΔΓ(s) ≡ Γ(L) - Γ(H) to be positive. Our result also resolves the ambiguity in the past measurements of the CP violating phase ϕ(s) to be close to zero rather than π. These conclusions are in agreement with the standard model expectations.