gebhart/patrepeval huggingface dataset:
Baicalein, a Novel Apoptotic Agent for Hepatoma Cell Lines:A Potential Medicine for Hepatoma (2000)

This study has demonstrated that baicalein has anticancer effectiveness against human hepatoma cells. The dose response of baicalein in Hep G2 and Hep J2 cells indicates that baicalein decreased viability >90%. In comparison, baicalein had only minimal effects on the viability of control Chang liver cells. Flow cytometric analysis showed that baicalein inhibited the cell cycle of Hep G2 cells in the S phase. In addition, baicalein treatment resulted in a decreased mitochondrial transmembrane potential and damaged the integrity of the cell membrane. The TdT-mediated dUTP-biotin nick end labeling assay results indicated that baicalein elicited a significant increase of DNA fragmentation in Hep G2 cells after incubation for 48 hours. These results indicate that baicalein is an effective antihepatoma agent with minimal influence on noncancer cells. The effects of baicalein on Hep G2 cells include inhibition of the S phase of the cell cycle, dysfunction of mitochondria, and initiation of apoptosis.
Design and implementation of automated regenerative braking of electric/hybrid electric vehicle (2012)

The hybrid electric vehicle (HEV) has become one of the most promising vehicles in the automobile industry due to its energy saving ability and low emission of harmful pollutants. An HEV can recover energy from the wheels, which had been wasted in the past, and reuse it to propel the vehicle at low speeds during high acceleration. The technology used depends on the goals set for the vehicle, which includes fuel efficiency, power, driving range, or reduced greenhouse gas emissions. The proposed project deals with the design, fabrication and testing of control logic circuit for regenerative braking of hybrid electric vehicle, by using multi–quadrant DC chopper (MQDC) with MOSFETs acting as switches. Monostable multi–vibrator is being used for firing the MOSFETs. The triggering for monostable multi–vibrator is provided by using the square wave generator. Micro–processor is interfaced with hardware circuit to show various modes of HEV. To realise this logic, a dedicated software programme has been developed in 'C' language.
Proposal of a universal test scene for depth map evaluation (2013)

Research in the area of depth map generation has been an active topic for the past few decades, but it is only recently, that depth map generation algorithms have found their way into consumer electronic devices. The issue is, that there is a lack in depth map testing environments for consumer devices which are using additional devices such as Time-of-Flight (ToF) or Infra-Red (IR cameras). For this reason, this paper introduces a new depth map testing scene suitable for consumer electronic devices, which can be reproduced by only following the instructions.
Automated, Multiplex Assay for High-Frequency Microsatellite Instability in Colorectal Cancer (2003)

The multiplex assay identifies colon cancers with MSI-H by assessing three highly accurate microsatellite markers. This assay identifies a smaller MSI-H cohort with more homogeneous clinical features and is superior as a marker of favorable prognosis. It merits prospective evaluation as a marker of prognosis and as a screening test for HNPCC.
Data from MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors (2023)

&lt;div&gt;Abstract&lt;p&gt;Malignant rhabdoid tumors (MRT) are highly aggressive pediatric cancers that respond poorly to current therapies. In this study, we screened several MRT cell lines with large-scale RNAi, CRISPR-Cas9, and small-molecule libraries to identify potential drug targets specific for these cancers. We discovered &lt;i&gt;MDM2&lt;/i&gt; and &lt;i&gt;MDM4&lt;/i&gt;, the canonical negative regulators of p53, as significant vulnerabilities. Using two compounds currently in clinical development, idasanutlin (MDM2-specific) and ATSP-7041 (MDM2/4-dual), we show that MRT cells were more sensitive than other p53 wild-type cancer cell lines to inhibition of MDM2 alone as well as dual inhibition of MDM2/4. These compounds caused significant upregulation of the p53 pathway in MRT cells, and sensitivity was ablated by CRISPR-Cas9–mediated inactivation of &lt;i&gt;TP53&lt;/i&gt;. We show that loss of SMARCB1, a subunit of the SWI/SNF (BAF) complex mutated in nearly all MRTs, sensitized cells to MDM2 and MDM2/4 inhibition by enhancing p53-mediated apoptosis. Both MDM2 and MDM2/4 inhibition slowed MRT xenograft growth &lt;i&gt;in vivo&lt;/i&gt;, with a 5-day idasanutlin pulse causing marked regression of all xenografts, including durable complete responses in 50% of mice. Together, these studies identify a genetic connection between mutations in the SWI/SNF chromatin-remodeling complex and the tumor suppressor gene &lt;i&gt;TP53&lt;/i&gt; and provide preclinical evidence to support the targeting of MDM2 and MDM4 in this often-fatal pediatric cancer.&lt;/p&gt;Significance:&lt;p&gt;This study identifies two targets, MDM2 and MDM4, as vulnerabilities in a deadly pediatric cancer and provides preclinical evidence that compounds inhibiting these proteins have therapeutic potential.&lt;/p&gt;&lt;/div&gt;
Automatic VHDL Code Generation for Fuzzy Logic Systems (2008)

To appear
Correlation between electroluminescence efficiency and stability in organic light-emitting devices under pulsed driving conditions (2006)

We investigated the effect of using pulsed current (pc) versus direct current (dc) driving mode on the electroluminescence (EL) efficiency and operational stability of tris(8-hydroxy-quinoline)aluminum (AlQ3)-based organic light-emitting devices. The results show that the dependence of device stability on the driving mode correlates with the relative EL efficiency under the pc and dc driving modes, where the mode that gives higher EL efficiency at any given current density also gives higher operational stability regardless of the duty cycle.
Modelling source directivity in room impulse response simulation for spherical microphone arrays (2015)

In this work we present a new room impulse response simulation for spherical microphone arrays taking into account source directivity. We calculate the emission angle of the sound ray leaving the source based on the location of the image and the receiver using Allen and Berkley's image method. We provide an implementation of a room impulse response simulator for a spherical microphone array including a directional source with arbitrary directivity. We validate our implementation considering the zeroth and the first-order reflections. Our results show a worst-case directional gain error of 7% in comparison with theoretical predictions.
Pharmacokinetics of single-dose intravenous or intramuscular administration of gentamicin in roosters (1990)

Healthy mature roosters (n = 10) were given gentamicin (5 mg/kg of body weight, IV) and, 30 days later, another dose IM. Serum concentrations of gentamicin were determined over 60 hours after each drug dosing, using a radioimmunoassay. Using nonlinear least-square regression methods, the combined data of IV and IM treatments were best fitted by a 2-compartment open model. The mean distribution phase half-life was 0.203 +/- 0.075 hours (mean +/- SD) and the terminal half-life was 3.38 +/- 0.62 hours. The volume of the central compartment was 0.0993 +/- 0.0097 L/kg, volume of distribution at steady state was 0.209 +/- 0.013 L/kg, and the total body clearance was 46.5 +/- 7.9 ml/h/kg. Intramuscular absorption was rapid, with a half-life for absorption of 0.281 +/- 0.081 hours. The extent of IM absorption was 95 +/- 18%. Maximal serum concentration of 20.68 +/- 2.10 micrograms/ml was detected at 0.62 +/- 0.18 hours after the dose. Kinetic calculations predicted that IM injection of gentamicin at a dosage of 4 mg/kg, q 12 h, and 1.5 mg/kg, q 8 h, would provide average steady-state serum concentrations of 6.82 and 3.83 micrograms/ml, with minimal steady-state serum concentrations of 1.54 and 1.50 micrograms/ml and maximal steady-state serum concentrations of 18.34 and 7.70 micrograms/ml, respectively.
Adaptive Proxy Anchor Loss for Deep Metric Learning (2022)

Deep metric learning (or simply called metric learning) uses the deep neural network to learn the representation of images, leading to widely used in many applications, e.g. image retrieval and face recognition. In the metric learning approaches, proxy anchor takes advantage of proxy-based and pair-based approaches to enable fast convergence time and robustness to noisy labels. However, in training the proxy anchor, selecting the hyperparameter margin is important to achieve a good performance. This selection requires expertise and is time-consuming. This paper proposes a novel method to learn the margin while training the proxy anchor approach adaptively. The proposed adaptive proxy anchor simplifies the hyperparameter tuning process while advancing the proxy anchor. We achieve state of the art on three public datasets with a noticeably faster convergence time. Our code is available at https: //github.com/tks1998/Adaptive-Proxy-Anchor
Broadband THz absorption spectrometer based on excitonic nonlinear optical effects (2019)

A broadly tunable THz source is realized via difference frequency generation, in which an enhancement to χ<sup>(3)</sup> that is obtained via resonant excitation of III-V semiconductor quantum well excitons is utilized. The symmetry of the quantum wells (QWs) is broken by utilizing the built-in electric-field across a p-i-n junction to produce effective χ<sup>(2)</sup> processes, which are derived from the high χ<sup>(3)</sup>. This χ<sup>(2)</sup> media exhibits an onset of nonlinear processes at ~4 W cm<sup>-2</sup>, thereby enabling area (and, hence, power) scaling of the THz emitter. Phase matching is realized laterally through normal incidence excitation. Using two collimated 130 mW continuous wave (CW) semiconductor lasers with ~1-mm beam diameters, we realize monochromatic THz emission that is tunable from 0.75 to 3 THz and demonstrate the possibility that this may span 0.2-6 THz with linewidths of ~20 GHz and efficiencies of ~1 × 10<sup>-5</sup>, thereby realizing ~800 nW of THz power. Then, transmission spectroscopy of atmospheric features is demonstrated, thereby opening the way for compact, low-cost, swept-wavelength THz spectroscopy.
Synthesis of Casein-Related Peptides and Phosphopeptides. I. Solution-Phase Synthesis and 13C N.M.R.-Spectroscopy of the N-α-Acetyl Octapeptide N-Methylamide Corresponding to Region 14-21 of Bovine β-Casein A2 (1987)

The octapeptide, Ac-Glu-Ser-Leu-Ser-Ser-Ser-Glu-Glu-NHMe (I), was synthesized by the solution-phase method by using the mixed anhydride coupling procedure for the fragment condensation of the Na-acetyl tripeptide, Ac-Glu(OBut)-Ser(But)-Leu-OH, with the pentapeptide N-methylamide hydrochloride, Cl.H2-Ser(But)-Ser(But)-Ser(But)-Glu(OBzl)-Glu(OBzl)-NHMe, followed by palladium-catalysed hydrogenolysis of Ac-Glu(OBut)-Ser(But)-Leu-Ser(But)-Ser(But)- Ser(But) Glu(OBzl)Glu(OBzl NHMe in trifluoroacetic acid. The synthesis of the two peptide fragments was accomplished in high yields and purity by using the repetitive excess mixed anhydride procedure and the isobutoxycarbonyl mixed anhydride of acetic acid for the rapid and high yielding N-acetylation of the tripeptide fragment. 13C n.m.r. spectroscopy was routinely used to monitor the efficiency of the coupling steps and to confirm the structure of octapeptide (1), signal assignments being possible for both the protected tri- and penta-peptides.
Desulfurisation of Penicillin-derived Disulfides — Synthesis of Some 4-Aza-azetidinones (1982)

Disulfides ( I ) ,(2) and (3) on treatment with triphenylphosphine i n refluxing benzene yielded 4-aza-azetidinones (7),( 8) and ( 9 ) in addition t o the expected sulfides (41, ( 5 ) and (6). 1The structures of these compounds were determined by H NMR and 1 3 c NMR data.Analogous products were also isolated from the reaction of azetidinone (10) with 2mercaptobenzothiazole.I n an earlier publication1, we described a new method of making thioesters (Scheme 1) starting from disulfides derived from penicillins using carboxylic acids and triphenylphosphine. Scheme 1This method was found to be applicable only t o disulfides possessing an acylamino group i n cis fashion to the disulfide function on t h e O-lactam nucleus.I n the absence of such an acylamino group, the above reaction yielded only the sulfur extrusion products.2 3 .Desulfurisation o f penicillin-derived disulfides i n general is a very facile process compared to other disulfides and occurs readily under mild conditions.Compounds (11, (2) and (3) could be desulfurised to the
Ultrafast Nanophotonics Applied to Quantum Optics and Hot Plasmonic Electron Generation (2019)

In this talk, recent efforts to use ultrafast spectroscopy to characterize light matter interactions with applications to single photon emitters for quantum optics and the generation of energetic carriers in plasmonic metamaterials are described.
Characterization of the optical quality and modulating properties of a PLZT modulator through Mueller matrix imaging polarimetry (1995)

The Physics Department at the University of Alabama in Huntsville (UAH) in collaboration with the Electrical and Computer Engineering Department of University of California, San Diego (UCSD) has applied Mueller matrix imaging polarimetry[1] to quantifying the polarization modulating properties of PLZT spatial light modulators. The purpose of this study was to evaluate the optical quality of a wire-bonded transmissive PLZT (9/65/35) modulator array, the uniformity of modulation across pixels, and the cross-talk between adjacent pixels.
Holistic CD metrology for process control of directed self-assembly (2013)

Toward 1x nm and beyond, some candidate lithography tools have been proposed as shown in Fig. 1. We believe multi-patterning with argon fluoride (ArF) immersion lithography will be used and subsequently replaced by extreme ultraviolet (EUV) lithography. This mainstream scenario, however, may have some risks. In regard to multi-patterning, cost is an issue because a number of process steps and two or more reticles are required for each layer. And in regard to EUV lithography, there are still some critical issues to be solved (e.g. light source, resist sensitivity, line edge roughness, and tool cost). Taking into account the worst case scenario, lithographers should prepare alternative approaches for patterning down to 1x nm.
A Linear Doubly Salient Permanent-Magnet Motor With Modular and Complementary Structure (2011)

A linear doubly salient permanent magnet (LDSPM) motor is particularly suitable for long stator applications due to its simple and low cost stator, which consists of only iron. This paper proposes a new LDSPM motor design with complementary and modular structure. The key of this structure is that the primary mover is composed of two modules whose positions are mutually four and one half of the stator pole pitch apart and there is a flux barrier between them. Hence, the back electromotive force (EMF) waveform and cogging force of the two modules have 180 electrical degree differences. This design results in the total cogging force being significantly reduced and the back-EMF of each phase becoming symmetrical because the even harmonics are canceled. For fair comparison, an existing linear LDSPM motor is designed based on the same electromagnetic parameters and compared by the means of finite element analysis (FEA). The results reveal that the proposed LDSPM motor can offer symmetrical back-EMF waveforms, smaller cogging force, lower force ripple, and higher magnet utilization factor than the existing one.
Study of anisotropy by transient elastography (2002)

From the low-frequency (150 Hz) shear-waves’ velocity, transient elastography can precisely measure the Youngs modulus in isotropic soft tissues. Using polarized shear waves, the character of an anisotropic media like fiber muscle is clearly visible. The polarization of elastic shear waves is obtained by the use of a rod (3×80 mm) as a low-frequency source. Indeed, the displacement field induced within a medium when an acoustic pulse (150 Hz) is applied at the surface by a rod is no more axisymmetric: the component of the displacement parallel to the rod is smaller than the component perpendicular to the rod. These polarized shear waves are well predicted by a numerical simulation of theoretical Greens functions. It is shown that the shear-wave velocities in a beef muscle (biceps femoris) strongly depend on the position of the rod as regard to the fibers. These results show that the anisotropic model for this muscle is the hexagonal system. Results in vivo on man biceps also show the existence of a low and a fast shear wave. We have started on this subject a collaboration with the myology institute at the hospital La Piti Salptrire in Paris.
Incorporating Prior Knowledge into Boosting (2002)

We describe a modification to the AdaBoost algorithm that permits the incorporation of prior human knowledge as a means of compensating for a shortage of training data. We give a convergence result for the algorithm.
Degradation of the Rubber Network during Dynamic Vulcanization of EPDM/PP Blends Using Phenolic Resol (2009)

Abstract Physical blends and thermoplastic vulcanizates (TPVs) based on EPDM and PP were prepared in a batch mixer. Dynamic vulcanization of TPVs using resol/SnCl 2 was studied as a function of time. Static and dynamic vulcanization of EPDM in the absence of PP were also studied. Crosslinking of EPDM in the absence of PP is more efficient via static than dynamic vulcanization. For EPDM/PP-based TPVs the extent of crosslinking reaction versus time decreases as the amount of EPDM increases. Degradation of the EPDM network occurs during dynamic vulcanization, due to the combined action of shearing and high temperature, and increases as EPDM becomes more and more the continuous phase.
Figure S2 and S3 from RAS–MAPK Reactivation Facilitates Acquired Resistance in <i>FGFR1</i>-Amplified Lung Cancer and Underlies a Rationale for Upfront FGFR–MEK Blockade (2023)

&lt;p&gt;Figure S2 shows ORF screen for resistance to FGFR inhibition and Figure S3 shows candidate mediators of resistance to FGFR inhibition based on ORF screen.&lt;/p&gt;
Mineralocorticoid Receptors Activation in Choroid Plexus and PVN Exaggerates Salt‐Induced Development of Hypertension in Stroke‐Prone Spontaneously Hypertensive Rats (2012)

Background In salt sensitive models, the increases in cerebrospinal fluid Na + concentration (CSF [Na]) derived from choroid plexus (CP) play a pivotal role in high salt (HS) induced hypertension. Mineralocorticoid receptors (MR) contribute to Na + handling. Therefore, we investigated whether MR in CP and paraventricular nucleus of hypothalamus (PVN) exaggerates salt‐induced development of hypertension in stroke‐prone spontaneously hypertensive rats (SHRSP). Methods and Results Serum glucocorticoid inducible kinase 1 (sgk1) expression levels in CP and PVN were greater in SHRSP than those in Wistar‐Kyoto (WKY) rats (N=6, P&lt;0.05) associated with increases in CSF[Na] (155.6 ± 0.81 vs. 152.8 ± 0.49 mM, P&lt;0.01). The depressor response to intracerebroventricular (ICV) infusion of MR blocker, eplerenone (10 ng) was greater in SHRSP than in WKY (Δarterial pressure (AP) −25.2 ± 1.4 vs. −8.2 ± 1.4 mmHg, N=5, P&lt;0.001). In SHRSP, HS intake (8%) increased AP and urinary norepinephrine excretion (uNE) compared with those by regular salt diet (2 weeks after ΔAP 41.7 ± 3.2 mmHg, ΔuNE 0.24 ± 0.07 μg/day, N=5, P&lt;0.05) associated with increases in MR and sgk1 expression in CP and PVN. These alterations were attenuated by ICV infusion of eplerenone (10 μg/kg/day). Conclusion MR activation in CP might contribute to increases in CSF[Na], thereby exaggerates salt‐induced development of hypertension via MR activation in PVN in SHRSP.
ChemInform Abstract: Recent Approaches for the Direct Use of Elemental Sulfur in the Synthesis and Processing of Advanced Materials (2015)

Abstract Review: [recent physical processing methods and synthetic procedures involving the direct use of elemental sulfur; 93 refs.
Femtosecond IR Laser Inscription of Bragg Gratings in Single- and Multimode Fluoride Fibers (2006)

We report for the first time the fabrication of fiber Bragg gratings in both single- and multimode undoped fluoride fibers using femtosecond 800-nm radiation and a phase mask. Grating spectra are presented along with an evaluation of the grating behavior at high temperature. Index changes of ~2times10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-4</sup> are achieved
New excitation codebook search methods to reduce perceptual degradation of CELP (2007)

Abstract In this paper, the authors propose three new excitation codebook search methods for suppressing the selection of an excitation code vector that has a high likelihood of producing pulse‐like degraded sound in a low‐bit‐rate CELP coder that uses a pulse‐like excitation code vector. The proposed methods are (1) adaptive weighting for coding distortion based on the state of the input speech, (2) weighting for coding distortion due to amplitude distribution distortion in the time direction, and (3) setting an upper limit for the coding distortion rate for pulse‐like excitation codebook searches. Although an excitation code vector with large coding distortion is selected if these proposed methods are set from the coding distortion minimization standard that is used in a conventional CELP excitation code vector search, there is an improvement in the quality that is perceived by the sense of hearing. The authors applied the proposed methods to a 4‐kbps CELP coder to verify their effectiveness according to subjective quality evaluation experiments. The results verified the effectiveness of the proposed methods by showing that the introduction of the proposed methods improved the MOS value by approximately 0.3 for clean speech and by approximately 0.4 for noise‐added speech. © 2007 Wiley Periodicals, Inc. Syst Comp Jpn, 38(8): 1–10, 2007; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/scj.20739
New Caryophyllene Derivatives from Betula litwinowii (2000)

Four new caryophyllene derivatives-14-hydroxy-4, 5-dihydro-beta-caryophyllene (1), 14-acetoxy-4, 5-dihydro-beta-caryophyllene (2), 4, 5-dihydro-beta-caryophyllene-14-al (3), and caryophylla-8(14)-en-5-one (4)-are reported from the essential oil of Betula litwinowii. Compounds 1-4 were characterized by MS and 1D and 2D NMR analyses and chemical transformations. The antibacterial and antifungal activity of 1 is also reported.
Don't Care Words with an Application to the Automata-Based Approach for Real Addition (Extended Abstract) (2006)

Automata are a useful tool in infinite-state model checking, since they can represent infinite sets of integers and reals. However, anal- ogous to the use of bdds to represent finite sets, the sizes of the automata are an obstacle in the automata-based set representation. In this paper, we generalize the notion of for bdds to word languages as a means to reduce the automata sizes. We show that the minimal weak deterministic Buchi automaton (wdba) with respect to a given don't care set, under certain restrictions, is uniquely determined and can be efficiently constructed. We apply don't cares to improve the efficiency of a decision procedure for the first-order logic over the mixed linear arithmetic over the integers and the reals based on wdbas.