gebhart/patrepeval huggingface dataset:
Development of Millimeter-Wave Communication Modem for Mobile Wireless Backhaul in Mobile Hotspot Network (2014)

The current cellular communications are optimized for low mobility users, meaning that their performance is degraded at high speed. Therefore, passengers in a high-speed train experience very poor radio link quality due to the significantly large number of simultaneous handovers. In addition, wireless data traffic is expanding exponentially in trains, subways and buses due to the widespread use of smartphones and mobile devices. To solve the inherent problem of cellular communication networks and meet the growing traffic demand, this paper proposes the mobile hotspot network of a millimeter-wave communication system as a mobile wireless backhaul. This paper describes the physical layer design of uplink and downlink in the proposed system, and the performances of uplink and downlink are evaluated under Rician fading channel conditions. The implemented baseband prototype of the proposed millimeter-wave communication modem is presented. This system can provide a Gbps data rate service in high-speed trains carrying hundreds of wireless Internet users.
Androgen Dependent Penile Development and Erection Physiology—A Molecular Connection? (2014)

No AccessJournal of UrologyEditorial1 Jul 2014Androgen Dependent Penile Development and Erection Physiology—A Molecular Connection? Arthur L. Burnett Arthur L. BurnettArthur L. Burnett More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.04.007AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Androgen Dependent Penile Development and Erection Physiology—A Molecular Connection?." The Journal of Urology, 192(1), pp. 8–9 References 1 : Low androgen induced penile maldevelopment involves altered gene expression of biomarkers of smooth muscle differentiation and a key enzyme regulating cavernous smooth muscle cell tone. J Urol2014; 192: 267. Link, Google Scholar 2 : Erectile physiological and pathophysiological pathways involved in erectile dysfunction. J Urol2003; 170: S6. Link, Google Scholar 3 : Endothelial nitric oxide synthase keeps erection regulatory function balance in the penis. Eur Urol2007; 51: 1732. Google Scholar 4 : Testosterone regulates PDE5 expression and in vivo responsiveness to tadalafil in rat corpus cavernosum. Eur Urol2005; 47: 409. Google Scholar 5 : Direct androgen regulation of PDE5 gene or the lack thereof. Int J Impot Res2013; 25: 81. Google Scholar 6 : Molecular pharmacotherapeutic targeting of PDE5 for preservation of penile health. J Androl2008; 29: 3. Google Scholar 7 : Phosphodiesterase type 5 regulation in the penile corpora cavernosa. J Sex Med2009; 6: 203. Google Scholar 8 : The physiological role of androgens in penile erection: regulation of corpus cavernosum structure and function. J Sex Med2005; 2: 759. Google Scholar 9 : Recent insights into androgen action on the anatomical and physiological substrate of penile erection. Asian J Androl2006; 8: 3. Google Scholar 10 : Phosphodiesterase type 5 as a pharmacologic target in erectile dysfunction. Urology2002; 60: 4. Google Scholar 11 Burnett AL, Anele UA, Trueheart IN et al: Randomized controlled trial of sildenafil for preventing recurrent ischemic priapism in sickle cell disease. Am J Med 2014; Epub ahead of print. Google Scholar © 2014 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 192Issue 1July 2014Page: 8-9 Advertisement Copyright & Permissions© 2014 by American Urological Association Education and Research, Inc.MetricsAuthor Information Arthur L. Burnett More articles by this author Expand All Advertisement PDF downloadLoading ...
ESR Investigation of Radical Addition Reactions to 2-[(2,4,6-Tri-tert-Butyl)Phenyl]-1-Phosphaalkyne (2003)

Radical additions of tert-butoxyl radical and alkylthiyl radicals to 2-[(2,4,6-tri-tert-butyl)phenyl]-1-phosphaalkyne have been investigated by ESR. The addition of oxygen or sulfur centered radical leads to an intermediate phosphavinyl σ-radical, which dimerizes to a 1,4-diphosphabutadiene, which undergoes a second radical addition to give a persistent π radical species. These species exhibit couplings with two different phosphorus nuclei and two different pairs of meta hydrogens. Our assignments were supported by 2H labeling and ab initio calculations.
Front Matter: Volume 7219 (2009)

This PDF file contains the front matter associated with SPIE Proceedings Volume 7219, including the Title Page, Copyright information, Table of Contents, Introduction, and the Conference Committee listing.
Capsule endoscopy examination of patients with obscure gastrointestinal bleeding: evaluation of clinical impact. (2005)

Patients with a positive result at WVCE had further intervention in 82% and were successfully treated in 67% of cases. We had no false positive results in this study, which suggest a high positive predictive value of WVCE. Moreover, negative WVCE had also an indirect clinical impact.
A Human Bone Marrow-Derived Stromal Cell Population with Hemogenic Potential (2015)

Abstract During ontogeny, definitive hematopoietic stem/progenitor cells (HSC) are thought to arise from vascular endothelial cells, through an endothelial-to-hematopoietic transition, a natural process that occurs in unique, specialized embryonic hemogenic endothelial cells. Developmental studies, and experiments using pluripotent stem cells in an effort to recapitulate this process and thereby gain a better understanding of the emergence of definitive hematopoiesis, have collectively led to the prevailing view that the hemogenic endothelium constitutes a transient population of cells within the embryo that rapidly disappears during development and is absent in the adult. Herein, we provide the first evidence that at early time points of gestation, prior to the establishment of hematopoiesis, a unique subpopulation of Stro-1+ cells present within the inner part of the developing human bone marrow co-expresses APLNR, a marker of angiogenic mesoderm. Moreover, these Stro-1+APLNR+ cells express multiple other markers described for hemogenic endothelium, and subsequently contribute to the vasculature, cartilage, and bone. Importantly, we also show that cells expressing these same markers of primitive mesoderm/hemogenic endothelium persist at low frequency within the adult marrow. These adult-derived cells can be extensively expanded in vitro without loss of potential, but lack hematopoietic colony-forming potential in vitro. However, upon transplantation into a fetal microenvironment, clonally-derived populations of these adult Stro1+ isolated stromal progenitors (SIPs) not only contribute to the vasculature and nascent BM niches, but also efficiently generate, at a clonal level, hematopoietic stem cells (HSC) that are capable of robust, multilineage hematopoietic reconstitution, with generation of both myeloid and lymphoid cells upon serial transplantation. In conclusion, our studies have thus uncovered the latent potential of a highly expandable population of seemingly vestigial adult human somatic cells, whose ontogenic history includes a phenotype identical to that described for hemogenic endothelium. We have also shown that, if provided with the appropriate/necessary inductive factors, these unique adult cells are capable of giving rise to hematopoietic cells that fulfill the gold standard criteria for bona fide HSC. Therefore, these cells could potentially be more amenable to reprogramming technologies, to produce HSC that could be used to treat/cure a broad variety of blood diseases. Disclosures No relevant conflicts of interest to declare.
Improved synchronization of HeartLander locomotion with physiological cycles (2011)

The variation of intrapericardial pressure due to the respiration and cardiac cycles greatly affects the locomotion efficiency of HeartLander, a minimally invasive surgical robot which adheres to and moves over the surface of the heart. This paper presents work which would allow HeartLander to improve motion efficiency by synchronizing its movement with the physiological cycles using a magnetic tracker. Using models of the respiratory and cardiac cycles generated using Kalman filtering techniques the work presented determines the phase of each physiological cycle in real time, which in turn enables synchronization of HeartLander to maximize locomotion efficiency.
Polymerization-induced diffusion as a tool to generate periodic relief : a combinatorial study (2006)

Polymeric relief structures are extensively used in display technology due to their ability to redirect light in a controlled way. Photo-embossing is a new photo-lithographic technique to generate surface relief structures using photopolymers. In the present paper we show a combinatorial methodology to explore this technique. We have prepared and evaluated (using automated atomic force microscopy) 2-dimensional libraries of photo-embossed gratings, each library with a gradient in period and a gradient in either exposure energy or development temperature or film thickness or photoinitiator concentration or monomer to binder ratio. We show how this combinatorial approach helps us to better understand the photo-embossing process. In addition, we show that this methodology is an effective tool to identify processing conditions resulting in optimum shape and height of the polymeric relief micro-structures to be used in specific applications.
Supplementary Table S1 from Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity (2023)

Supplementary Table S1 from Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity
Impact of Contaminating DNA in Whole-Genome Amplification Kits Used for Metagenomic Shotgun Sequencing for Infection Diagnosis (2017)

Whole-genome amplification (WGA) is a useful tool for amplification of very small quantities of DNA for many uses, including metagenomic shotgun sequencing for infection diagnosis. Depending on the application, background DNA from WGA kits can be problematic. Three WGA kits were tested for their utility in a metagenomics approach to identify the pathogens in sonicate fluid comprised of biofilms and other materials dislodged from the surfaces of explanted prosthetic joints using sonication. The Illustra V2 Genomiphi, Illustra single cell Genomiphi, and Qiagen REPLI-g single cell kits were used to test identical sonicate fluid samples. Variations in the number of background reads, the genera identified in the background, and the number of reads from known pathogens known to be present in the samples were observed between kits. These results were then compared to those obtained with a library preparation without prior WGA using an NEBNext Ultra II paired-end kit, which requires a very small amount of input DNA. This approach also resulted in the presence of contaminant bacterial DNA and yielded fewer reads from the known pathogens. These findings highlight the impact that WGA kit selection can have on metagenomic analysis of low-biomass samples and the importance of the careful selection and consideration of the implications of using these tools.
IL-10 Induces CCR6 Expression During Langerhans Cell Development While IL-4 and IFN-γ Suppress It (2001)

Immune responses are initiated by dendritic cells (DC) that form a network comprising different populations. In particular, Langerhans cells (LC) appear as a unique population of cells colonizing epithelial surfaces. We have recently shown that macrophage-inflammatory protein-3alpha/CCL20, a chemokine secreted by epithelial cells, induces the selective migration of LC among DC populations. In this study, we investigated the effects of cytokines on the expression of the CCL20 receptor, CCR6, during differentiation of LC. We found that both IL-4 and IFN-gamma blocked the expression of CCR6 and CCL20 responsiveness at different stages of LC development. The effect of IL-4 was reversible and most likely due to the transient blockade of LC differentiation. In contrast, IFN-gamma-induced CCR6 loss was irreversible and was concomitant to the induction of DC maturation. When other cytokines involved in DC and T cell differentiation were tested, we found that IL-10, unlike IL-4 and IFN-gamma, maintained CCR6 expression. The effect of IL-10 was reversible and upon IL-10 withdrawn, CCR6 was lost concomitantly to final LC differentiation. In addition, IL-10 induced the expression of CCR6 and responsiveness to CCL20 in differentiated monocytes that preserve their ability to differentiate into mature DC. Finally, TGF-beta, which induces LC differentiation, did not alter early CCR6 expression, but triggered its irreversible down-regulation, in parallel to terminal LC differentiation. Taken together, these results suggest that the recruitment of LC at epithelial surface might be suppressed during Th1 and Th2 immune responses, and amplified during regulatory immune responses involving IL-10 and TGF-beta.
Reduced Dose Lenalidomide Is Safe and Effective in Deletion (5q) MDS Patients with Severe Renal Impairment: Report of Two Cases. (2007)

Abstract Introduction: Lenalidomide (Len) is highly active in the treatment of MDS with deletion 5q (del[5q]) (List et al. NEJM 2006). Patients with renal impairment have often been excluded from Len studies because of potential for delayed excretion with increased risk for adverse events. We present 2 MDS patients with 5q− syndrome and renal impairment who were treated with Len at reduced dosage. Patient 1: A 50-year-old woman presented with shortness of breath on exertion, pallor, and tachycardia. Laboratory tests showed hemoglobin (Hb) 3.9 g/dL with significant macrocytosis; white blood cell count (WBC) of 3.2 × 109/L; and creatinine 2.66 mg/dL (normal value, &lt; 1.1 mg/dL). Bone marrow aspirate was consistent with World Health Organization 5q− syndrome. Abdominal ultrasound revealed unilateral renal agenesis. The patient required 2 packed red blood cell (RBC) units every 2 to 3 weeks. Glomerular filtration rate (GFR) was severely impaired (23 mL/min). Len was initiated at 5 mg/d and increased to 10 mg/d after 4 weeks. The patient showed a fast and sustained hematologic response, Hb of 10–11 g/dL without exogenous erythropoietin, and achieved transfusion independence within 6 weeks. Due to decreased WBC of 1.3 × 109/L, and a platelet count (plt) of 57 × 109/L, indicating thrombocytopenia, Len was adjusted to a daily alternating dose of 5 mg and 10 mg, respectively. Complete cytogenetic remission was achieved by 6 months of treatment. Patient 2: An 83-year-old female presented with sustained anemia despite treatment with recombinant erythropoietin. Bone marrow findings and peripheral blood features were consistent with the 5q− syndrome. The patient was transfusion dependent and received a single treatment cycle with azacitidine, but developed acute renal insufficiency, accompanied by an elevation in creatinine to 4.8 mg/dL. She continued supportive care measures receiving 2 units of RBC every 4 weeks. Len was initiated at 5 mg daily. GFR at start of therapy was moderately decreased (31 mL/min). After 6 weeks of treatment the patient developed a generalized rash, occupying 30–50% of the body, which subsided with temporary therapy cessation. Laboratory studies at 6 weeks revealed a WBC of 1.58 × 109/L, with an absolute neutrophil count (ANC) of 3.5 × 109/L, Hb of 12.3 g/dL and plt of 42 × 109/L. Because of progressive decline in the patient’s Hb levels Len was resumed 5 months later at a dose of 5 mg 3 times per week. This was well tolerated. Complete cytogenetic remission was achieved after 10 months of follow-up. Conclusions: These cases show that Len can be administered safely to MDS patients with renal insufficiency and with preserved clinical activity. In addition, the present observations suggest that Len therapy could abrogate the need for use of additional erythropoietin in these patients.
Yeast carbamyl phosphate synthetase. Structure of the yeast gene and homology to Escherichia coli carbamyl phosphate synthetase. (1983)

A cloned fragment of yeast chromosomal DNA carrying the gene CPA2 coding for the large subunit of arginine-specific carbamyl phosphate synthetase has been sequenced. The cloned DNA has a 3,354-nucleotide long continuous reading frame coding for a polypeptide of 1,117 amino acids. The calculated molecular weight of the encoded polypeptide is 123,787, in good agreement with the reported molecular weight of the yeast carbamyl phosphate synthetase large subunit. The amino acid sequence of yeast carbamyl phosphate synthetase is homologous to the recently determined sequence of Escherichia coli carbamyl phosphate synthetase (Nyunoya, H., and Lusty, C. J. (1983) Proc. Natl. Acad. Sci. U. S. A. 80, 4629-4633) over almost the entire length of the protein. Like the E. coli large subunit, the yeast enzyme exhibits an extensive internal homology between its NH2- and carboxyl-terminal halves. The internal homology in both the yeast and E. coli proteins indicates that the gene coding for the large subunit of carbamyl phosphate synthetase was derived from a tandem duplication which occurred prior to the divergence of eukaryotes and prokaryotes.
Resonance Raman De-Enhancement Caused by Excited State Mixed Valence (2007)

Resonance Raman and absorption spectra of 9,10-bis(2-tert-butyl-2,3-diazabicyclo[2.2.2]oct-3-yl)-anthracene (2) are measured and analyzed. The contribution of the individual vibrational normal modes to the reorganization energy is investigated. Excited-state mixed valence in this system is analyzed using density functional theory electronic structure calculations. The resonance Raman excitation profiles exhibit a resonance de-enhancement effect around 20 725 cm-1, but a corresponding feature is not observed in the absorption spectrum. This unusual observation is attributed to the presence of a dipole-forbidden, vibronically allowed component of the split mixed valence excited state. The de-enhancement dip is calculated quantitatively and explained in terms of the real and imaginary components of the polarizabilities of the two overlapping excited states.
Using musical acoustics to teach digital signal processing, scientific computing, and human–computer interface technology (1997)

This talk discusses the role of musical acoustics in teaching engineering courses offered at the Stanford Center for Computer Research in Music and Acoustics, and in the Princeton University Department of Computer Science. For digital signal processing, musical acoustics is used to motivate and demonstrate mathematical concepts such as zeroes (multi-path cancellations in rooms), poles (resonant modes in a guitar), nonlinearity, and instability (what happens when one turns up the guitar amp). Simultaneous real-time visual and auditory displays build intuition and interest. For scientific computing, the pendulum provides a simple but meaningful first experience in numerical methods. By setting up differential equations from a physical description, noting the possibility of linearizing assumptions, and solving the system discretely on a computer, students discover how parameter values affect accuracy and stability. By solving both with and without the linearizing assumption, then placing a soundfile header on the output data, differences in frequency and waveform can be easily detected. Techniques are extended in plucked string and vibrating membrane simulations. For human–computer interface technology, musical instruments are perfect examples of effective human-artifact interfaces. Labs using computer sound synthesis clarify basic interaction concepts such as latency and cross-modal perception.
Upregulation and Expression Patterns of the Angiogenic Transcription Factor Ets-1 in Alzheimer's Disease Brain (2013)

Immunohistochemical staining has been used to determine expression patterns of the angiogenic transcription factor, Ets-1, in the brains of Alzheimer's disease (AD) individuals. Brain tissue from non-demented controls showed little expression of Ets-1 whereas in AD brain tissue, Ets-1 was ubiquitously expressed in cortex and hippocampus. Double immunostaining with von Willerbrand factor demonstrated prominent Ets-1 intravascular immunoreactivity (ir) in AD cortical microvessels. In addition, Ets-1 also exhibited extravascular expression characterized by a diffuse pattern of Ets-1 ir in AD brain. Double staining also showed Ets-1 colocalization in microvasculature with the potent angiogenic agent, vascular endothelial growth factor (VEGF). Cell-associated tumor necrosis factor-α (TNF-α), a pro-inflammatory cytokine with pro-angiogenic activity, was primarily associated with diffuse extravascular Ets-1 ir. Clusters of HLA-DR positive microglia, resident immune cells of brain which release TNF-α, were also localized with diffuse Ets-1. Intravascular Ets-1 ir was maximally co-localized with soluble amyloid-β peptide (Aβ), Aβ1-40, in microvasculature whereas diffuse extravascular Ets-1 ir appeared in proximity to Aβ plaques in brain parenchyma. Similar overall results were obtained for patterns of Ets-1 staining in AD hippocampal tissue. This work provides novel findings on expression of the angiogenic transcription factor, Ets-1, in vascular remodeling and its association with pro-angiogenic factors, reactive microglia, and Aβ deposition in AD brain.
On the Number and 3-D Placement of In-Band Full-Duplex Enabled Drone-Mounted Base-Stations (2018)

Drone-mounted base-stations (DBSs) have attracted much attention because of their mobile, flexible and low-cost networking features. In-band full-duplex (IBFD) is a promising technology to potentially double the spectrum efficiency, and thus equipping DBSs with IBFD to provision services may increase throughput and reduce the number of required DBSs for the same coverage. We propose a dynamic drone-base-station-placement algorithm to solve the 3-D DBS placement problem by incorporating IBFD-enabled DBS communications for both access links and backhaul links of DBSs, which is NP-hard. Simulation results have demonstrated that our proposed algorithm significantly increases the throughput and reduces the data rate block ratio as compared to that of other strategies.