Mycosis Fungoides Arthropathy (1991)

Brief Reports1 April 1991Mycosis Fungoides ArthropathyRobert G. Berger, MD, Susan J. Knox, MD, PhD, Ronald Levy, MD, Jeffrey L. Sklar, MD, PhD, Philip Cohen, MD, Thomas Reichert, MD, PhDRobert G. Berger, MDSearch for more papers by this author, Susan J. Knox, MD, PhDSearch for more papers by this author, Ronald Levy, MDSearch for more papers by this author, Jeffrey L. Sklar, MD, PhDSearch for more papers by this author, Philip Cohen, MDSearch for more papers by this author, Thomas Reichert, MD, PhDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-7-571 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWe report the case of a patient with mycosis fungoides who developed a progressive arthropathy from malignant synovial infiltration. The arthropathy responded to treatment with a chimeric, human-murine monoclonal antibody against T-helper cells.Case ReportAt 39 years of age, this previously healthy woman developed a rash over her abdomen and, subsequently, over her thighs and arms. The rash was characterized by hyperkeratotic, erythematous plaques. Two years later, she developed a symmetric, nonerosive small hand-joint arthritis. Tests for rheumatoid factor and antinuclear antibody had negative results.Over the next year, the patient's rheumatic and cutaneous symptoms responded to neither hydroxychloroquine...References1. KnoxLevyHodgkinson SRS. Observations on the effect of chimeric anti-CD4 monoclonal antibody in patients with mycosis fungoides. Blood. 1991;[In press]. CrossrefMedlineGoogle Scholar2. FriesSpitzKrainesHolman JPRH. Measurement of patient outcome in arthritis. Arthritis Rheum. 1980;23:137-45. CrossrefMedlineGoogle Scholar3. ClearyChaoWarnkeSklar MJRJ. Immunoglobulin gene rearrangement as a diagnostic criterion of B-cell lymphoma. Proc Natl Acad Sci USA. 1984;81:593-7. CrossrefMedlineGoogle Scholar4. FeinbergVogelstein AB. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal Biochem. 1983;132:6-13. CrossrefMedlineGoogle Scholar5. WeissWoodEllisenReynoldsSklar LGLTJ. Clonal T-cell populations in pityriasis lichenoides et varioliformis acuta (Mucha-Habermann disease). Am J Pathol. 1987;126:417-21. MedlineGoogle Scholar6. KeystoneMindenKlock EMR. Structure of T cell antigen receptor beta chain in synovial fluid cells from patients with rheumatoid arthritis. Arthritis Rheum. 1988;31:1555-7. CrossrefMedlineGoogle Scholar7. SchocketHuffCarrNorris AJRD. Humoral immunity in stage I mycosis fungoides: an increased incidence of lymphocytotoxic antibodies. Br J Dermatol. 1982;107:285-91. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Robert G. Berger, MD; Susan J. Knox, MD, PhD; Ronald Levy, MD; Jeffrey L. Sklar, MD, PhD; Philip Cohen, MD; Thomas Reichert, MD, PhDFrom the University of North Carolina School of Medicine, Chapel Hill, North Carolina; Stanford University School of Medicine, Stanford California; Becton-Dickinson, Mountain View, California; and Harvard Medical School, Boston, Massachusetts. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byManifestaciones osteoarticulares de las hemopatías malignas (mieloma excluido)Paraneoplastic arthritis in a patient with Sézary syndromeClonal identity between skin and synovial tissue in a case of mycosis fungoides with polyarthritisSynovial T-Cell Lymphoma of the Stifle in a DogPeripheral T-cell Lymphoma with Eosinophilia Presenting as Monoarthritis: A Case StudyOligoarthrite, hippocratisme digital et lésions cutanéesRHEUMATIC MANIFESTATIONS OF DYSPROTEINEMIAS AND LYMPHOPROLIFERATIVE DISORDERSLymphomatous Polyarthritis in Patients with Peripheral T-Cell Lymphoma 1 April 1991Volume 114, Issue 7Page: 571-572KeywordsAntinuclear antibodiesArthritisCellsHematology and oncologyHydroxychloroquineImmunologyMonoclonal antibodiesRashesRheumatoid arthritisRheumatology ePublished: 1 December 2008 Issue Published: 1 April 1991 PDF downloadLoading ...