gebhart/patrepeval huggingface dataset:
Improved Charge Transport and Reduced Non-Geminate Recombination in Organic Solar Cells by Adding Size-Selected Graphene Oxide Nanosheets (2019)

Size-selected graphene oxide (GO) nanosheets were used to modify the bulk heterojunction (BHJ) morphology and electrical properties of organic photovoltaic (OPV) devices. The GO nanosheets were prepared with sizes ranging from several hundreds of nanometers to micrometers by using a physical sonication process and were then incorporated into PTB7:PC<sub>71</sub>BM photoactive layers. Different GO sizes provide varied portions of the basal plane where aromatic sp<sup>2</sup>-hybridized regions are dominant and edges where oxygenated functional groups are located; thus, GO size distributions affect the GO dispersion stability and morphological aggregation of the BHJ layer. Electron delocalization by sp<sup>2</sup>-hybridization and the electron-withdrawing characteristics of functional groups p-dope the photoactive layer, giving rise to increasing carrier mobilities. Hole and electron mobilities are maximized at GO sizes of several hundreds of nanometers. Consequently, non-geminate recombination is significantly reduced by these facilitated hole and electron transports. The addition of GO nanosheets decreases the recombination order of non-geminate recombination and increases the generated carrier density. This reduction in the non-geminate recombination contributes to an increased power conversion efficiency of PTB7:PC<sub>71</sub>BM OPV devices as high as 9.21%, particularly, by increasing the fill factor to 70.5% in normal devices and 69.4% in inverted devices.
Asiatic acid, a pentacyclic triterpene from Centella asiatica, is neuroprotective in a mouse model of focal cerebral ischemia (2009)

Asiatic acid, a triterpenoid derivative from Centella asiatica, has shown biological effects such as antioxidant, antiinflammatory, and protection against glutamate- or beta-amyloid-induced neurotoxicity. We investigated the neuroprotective effect of asiatic acid in a mouse model of permanent cerebral ischemia. Various doses of asiatic acid (30, 75, or 165 mg/kg) were administered orally at 1 hr pre- and 3, 10, and 20 hr postischemia, and infarct volume and behavioral deficits were evaluated at day 1 or 7 postischemia. IgG (blood-brain barrier integrity) and cytochrome c (apoptosis) immunostaining was carried out at 24 hr postischemia. The effect of asiatic acid on stress-induced cytochrome c release was examined in isolated mitochondrial fractions. Furthermore, its effects on cell viability and mitochondrial membrane potential were studied in HT-22 cells exposed to oxygen-glucose deprivation. Asiatic acid significantly reduced the infarct volume by 60% at day 1 and by 26% at day 7 postischemia and improved neurological outcome at 24 hr postischemia. Our studies also showed that the neuroprotective properties of asiatic acid might be mediated in part through decreased blood-brain barrier permeability and reduction in mitochondrial injury. The present study suggests that asiatic acid may be useful in the treatment of cerebral ischemia.
Wnt5a Drives an Invasive Phenotype in Human Glioblastoma Stem-like Cells (2016)

Brain invasion by glioblastoma determines prognosis, recurrence, and lethality in patients, but no master factor coordinating the invasive properties of glioblastoma has been identified. Here we report evidence favoring such a role for the noncanonical WNT family member Wnt5a. We found the most invasive gliomas to be characterized by Wnt5a overexpression, which correlated with poor prognosis and also discriminated infiltrating mesenchymal glioblastoma from poorly motile proneural and classical glioblastoma. Indeed, Wnt5a overexpression associated with tumor-promoting stem-like characteristics (TPC) in defining the character of highly infiltrating mesenchymal glioblastoma cells (Wnt5a<sup>High</sup>). Inhibiting Wnt5a in mesenchymal glioblastoma TPC suppressed their infiltrating capability. Conversely, enforcing high levels of Wnt5a activated an infiltrative, mesenchymal-like program in classical glioblastoma TPC and Wnt5a<sup>Low</sup> mesenchymal TPC. In intracranial mouse xenograft models of glioblastoma, inhibiting Wnt5a activity blocked brain invasion and increased host survival. Overall, our results highlight Wnt5a as a master regulator of brain invasion, specifically TPC, and they provide a therapeutic rationale to target it in patients with glioblastoma. <i>Cancer Res; 77(4); 996-1007. ©2016 AACR</i>.
Radioactivity-Synchronized Fluorescence Enhancement Using a Radionuclide Fluorescence-Quenched Dye (2009)

We demonstrate the first evidence of radioactivity-synchronized fluorescence quenching of a near-infrared light-emitting dye by a radionuclide, (64)Cu, and subsequent fluorescence enhancement upon (64)Cu decay to the daughter isotopes (64)Ni and (64)Zn. The dynamic switch from high radioactivity and low fluorescence to low radioactivity and high fluorescence is potentially useful for developing complementary multimodal imaging and detection platforms for chemical, environmental, and biomedical applications as well as for unraveling the mechanisms of metal-induced dynamic fluorescence changes.
The AMPERE Project: : A Model-driven development framework for highly Parallel and EneRgy-Efficient computation supporting multi-criteria optimization (2020)

The high-performance requirements needed to implement the most advanced functionalities of current and future Cyber-Physical Systems (CPSs) are challenging the development processes of CPSs. On one side, CPSs rely on model-driven engineering (MDE) to satisfy the non-functional constraints and to ensure a smooth and safe integration of new features. On the other side, the use of complex parallel and heterogeneous embedded processor architectures becomes mandatory to cope with the performance requirements. In this regard, parallel programming models, such as OpenMP or CUDA, are a fundamental brick to fully exploit the performance capabilities of these architectures. However, parallel programming models are not compatible with current MDE approaches, creating a gap between the MDE used to develop CPSs and the parallel programming models supported by novel and future embedded platforms.The AMPERE project will bridge this gap by implementing a novel software architecture for the development of advanced CPSs. To do so, the proposed software architecture will be capable of capturing the definition of the components and communications described in the MDE framework, together with the non-functional properties, and transform it into key parallel constructs present in current parallel models, which may require extensions. These features will allow for making an efficient use of underlying parallel and heterogeneous architectures, while ensuring compliance with non-functional requirements, including those on real-time performance of the system.
Guidelines and diagnostic algorithm for patients with suspected systemic mastocytosis: a proposal of the Austrian competence network (AUCNM). (2013)

Systemic mastocytosis (SM) is a hematopoietic neoplasm characterized by pathologic expansion of tissue mast cells in one or more extracutaneous organs. In most children and most adult patients, skin involvement is found. Childhood patients frequently suffer from cutaneous mastocytosis without systemic involvement, whereas most adult patients are diagnosed as suffering from SM. In a smaller subset of patients, SM without skin lesions develops which is a diagnostic challenge. In the current article, a diagnostic algorithm for patients with suspected SM is proposed. In adult patients with skin lesions and histologically confirmed mastocytosis in the skin (MIS), a bone marrow biopsy is recommended regardless of the serum tryptase level. In adult patients without skin lesions who are suffering from typical mediator-related symptoms, the basal serum tryptase level is an important diagnostic parameter. In those with slightly elevated tryptase (15-30 ng/ml), additional non-invasive investigations, including a KIT mutation analysis of peripheral blood cells and sonographic analysis, is performed. In adult patients in whom i) KIT D816V is detected or/and ii) the basal serum tryptase level is clearly elevated (> 30 ng/ml) or/and iii) other clinical or laboratory features are suggesting the presence of occult mastocytosis, a bone marrow biopsy should be performed. In the absence of KIT D816V and other indications of mastocytosis, no bone marrow investigation is required, but the patient's course and the serum tryptase levels are examined in the follow-up.
Regulation of aminopeptidase-N (CD13) and Fc epsilon RIIb (CD23) expression by IL-4 depends on the stage of maturation of monocytes/macrophages (1992)

IL-4 has multiple biologic activities and it has been shown to have effects on B and T lymphocytes, mast cells, NK cells, and monocytes. We studied the influence of IL-4 on the expression of cell membrane determinants, in particular aminopeptidase-N (CD13) and Fc epsilon RIIb (CD23), on human peripheral blood monocytes. We compared the response of monocytes with the response of human alveolar macrophages and monocytic cell lines (U937 and THP1), as mature and more immature representatives of the mononuclear phagocyte system, respectively. A dose-dependent increase of the expression of CD13 Ag was observed when monocytes were cultured with IL-4. Kinetic analyses revealed that this induction was maximal after 2 to 3 days of culture and resembled the kinetics of IL-4-induced expression of Fc epsilon RIIb on monocytes. This IL-4-induced increase was absent when monocytes were cultured with IL-4 and an anti-IL-4 antiserum. Concomitantly, an IL-4-induced increase in leucine-aminopeptidase activity could be observed. Northern blot analysis showed that incubation of monocytes with IL-4 induced a marked increase in CD13 mRNA. Alveolar macrophages also exhibited an increase in CD13 Ag expression when exposed to IL-4. Surprisingly, IL-4 was unable to induce expression of Fc epsilon RIIb on alveolar macrophages. U937 and THP1 cells did not show an induction of CD13 Ag when cultured in the presence of IL-4. However, IL-4 did induce the expression of Fc epsilon RIIb on both cell lines, suggesting the presence of functional IL-4R. Our data demonstrate that IL-4 increases the expression of CD13 Ag on monocytes. This IL-4-induced increase can also be observed in more mature monocytic cells such as alveolar macrophages, but is absent in immature cells such as U937 or THP1 cells. This is functionally accompanied by an increase in leucine-aminopeptidase activity and may be part of the general activation of monocytes/macrophages by IL-4. In conclusion, the data suggest that IL-4 responsiveness, in particular the induction of CD13 Ag and Fc epsilon RIIb expression, may be dependent on the stage of maturation of monocytes/macrophages.
Attenuated live infectious bronchitis virus QX vaccine disseminates slowly to target organs distant from the site of inoculation (2019)

Infectious bronchitis (IB) is a highly contagious respiratory disease of poultry, caused by the avian coronavirus infectious bronchitis virus (IBV). Currently, one of the most relevant genotypes circulating worldwide is IBV-QX (GI-19), for which vaccines have been developed by passaging virulent QX strains in embryonated chicken eggs. Here we explored the attenuated phenotype of a commercially available QX live vaccine, IB Primo QX, in specific pathogens free broilers. At hatch, birds were inoculated with QX vaccine or its virulent progenitor IBV-D388, and postmortem swabs and tissues were collected each day up to eight days post infection to assess viral replication and morphological changes. In the trachea, viral RNA replication and protein expression were comparable in both groups. Both viruses induced morphologically comparable lesions in the trachea, albeit with a short delay in the vaccinated birds. In contrast, in the kidney, QX vaccine viral RNA was nearly absent, which coincided with the lack of any morphological changes in this organ. This was in contrast to high viral RNA titers and abundant lesions in the kidney after IBV D388 infection. Furthermore, QX vaccine showed reduced ability to reach and replicate in conjunctivae and intestines including cloaca, resulting in significantly lower titers and delayed protein expression, respectively. Nephropathogenic IBVs might reach the kidney also via an ascending route from the cloaca, based on our observation that viral RNA was detected in the cloaca one day before detection in the kidney. In the kidney distal tubular segments, collecting ducts and ureter were positive for viral antigen. Taken together, the attenuated phenotype of QX vaccine seems to rely on slower dissemination and lower replication in target tissues other than the site of inoculation.
Sex Differences in Cardiovascular Pathophysiology (2018)

Consistent epidemiological data demonstrate that patients with heart failure with preserved ejection fraction (HFpEF) are more likely to be women than men. Exploring mechanisms behind this sex difference in heart failure epidemiology may enrich the understanding of underlying HFpEF pathophysiology and phenotypes, with the ultimate goal of identifying therapeutic approaches for the broader HFpEF population. In this review we evaluate the influence of sex on the key domains of cardiac structure and function, the systemic and pulmonary circulation, as well as extracardiac factors and comorbidities that may explain the predisposition of women to HFpEF. We highlight the potential role of factors exclusive to or more prevalent in women such as pregnancy, preeclampsia, and iron deficiency. Finally, we discuss existing controversies and gaps in knowledge, as well as the clinical importance of known sex differences in the context of the potential need for sex-specific diagnostic criteria, improved risk stratification models, and targeted therapies.
Codebook Based Two-Time Scale Resource Allocation Design for IRS-Assisted eMBB-URLLC Systems (2022)

This paper investigates the resource allocation algorithm design for wireless systems assisted by large intelligent reflecting surfaces (IRSs) with coexisting enhanced mobile broadband (eMBB) and ultra reliable low-latency communication (URLLC) users. We consider a two-time scale resource allocation scheme, whereby the base station's precoders are optimized in each mini-slot to adapt to newly arriving URLLC traffic, whereas the IRS phase shifts are reconfigured only in each time slot to avoid excessive base station-IRS signaling. To facilitate efficient resource allocation design for large IRSs, we employ a codebook-based optimization framework, where the IRS is divided into several tiles and the phase-shift elements of each tile are selected from a pre-defined codebook. The resource allocation algorithm design is formulated as an optimization problem for the maximization of the average sum data rate of the eMBB users over a time slot while guaranteeing the quality-of-service (QoS) of each URLLC user in each mini-slot. An iterative algorithm based on alternating optimization (AO) is proposed to find a high-quality suboptimal solution. As a case study, the proposed algorithm is applied in an industrial indoor environment modelled via the Quadriga channel simulator. Our simulation results show that the proposed algorithm design enables the coexistence of eMBB and URLLC users and yields large performance gains compared to three baseline schemes. Furthermore, our simulation results reveal that the proposed two-time scale resource allocation design incurs only a small performance loss compared to the case when the IRSs are optimized in each mini-slot.
Knowledge Flow Networks and Communities of Practice in Business Process Management (2010)

Business process management (BPM) is a common approach used in dynamic and complicated environment throughout the organizations’ operation. Knowledge Flow Networks (KFN) and Communities of Practice (CoPs), especially that resulting from innovation needs, is regarded as a BPM issue. It involves both personal and organizational aspects, and is an iteration of the transmission between explicit and tacit knowledge. We discuss business process management in the context of Knowledge Management (KM) and knowledge flow networks. KFN, unlike workflow, can often transcend organizational boundaries and are distinct and different than workflow models. In this chapter, we develop, implement, and analyze a CoPs Centered KFN model in a multinational organization. The CoPs Centered KFN model is underpinned in a CoPs model built around four organization performance evaluation dimensions and sixteen criteria. Many criteria and clusters need to be taken into consideration while establishing a CoPs model. For this purpose, fuzzy multi-criteria decision making and cluster analysis techniques for evaluation of the CoPs Centered KFN model are employed in this chapter. A Dynamic Knowledge Flow Activity Analysis Model is also defined as part of our ongoing and future work.
Analysis of expression of CD2, CD3, and T cell antigen receptor molecules during early human fetal thymic development. (1988)

To define early stages of T cell maturation during human fetal thymic development, we have used mAb reactive with CD2, CD3, and TCR molecules in indirect immunofluorescence assays on a series of early human fetal thymic specimens. Using a technique of quantitating the relative proportions of fluorescent-positive cells present in tissue sections, we found at 8.5 wk of gestational age after arrival of CD7+ T cell precursors into the thymic rudiment, 60% of thymic CD7+ cells were CD2+, 4% were CD3+ and none was TCR-delta+ or TCR beta+. Moreover, cells reactive with anti-CD2 antibodies against T11(2) and T11(3) epitopes of CD2 as well as thymic stromal cells expressing the CD2 ligand, lymphocyte function associated Ag-3, were also present at 8.5 wk. From 9.5 wk to birth TCR beta+ cells increased to include greater than 90% of all CD7+ cells while TCR-delta+ cells fell from a peak of 11% of CD7+ cells at 9.5 wk to 1% of CD7+ cells at birth. These data suggest that epitopes of CD2 molecules are expressed early on during fetal thymic development. Moreover, these data suggest that CD7+, CD2+, cytoplasmic CD3+ T cell precursors in man give rise to both TCR-delta+ T cells as well as to T cells expressing TCR-alpha beta.
Directly Pumped Silicon Lasers (2008)

Over the past two decades, researchers have tried mightily to enhance silicon’s ability to emit light. Yet electrically pumped silicon lasers remain tantalizingly out of reach. These authors describe how the approaches that have been tried so far might be successfully combined.
Miniaturized Handheld Confocal Microscopy for Neurosurgery (2010)

Miniaturized handheld confocal imaging may assist neurosurgeons in detecting infiltrative brain tumor margins during surgery. It may help to avoid sampling error during biopsy of heterogeneous glial neoplasms, with the potential to supplement conventional intraoperative frozen section pathology. Clinical trials are warranted on the basis of these promising initial results.
Application of Three Methods in Determining the Effectiveness of Surge Protection Systems in Gas Compressor Stations (2012)

Compression Systems are designed and operated in a manner to eliminate or minimize the potential for surge, which is a dynamic instability that is very detrimental to the integrity of the unit. Compressor surge can occur when compressors are subjected to rapid transients such as one following emergency shutdown (ESD) or power failure. To prevent this from occurring, compressor stations are designed with recycle systems and special types of recycle valves, which are required to open upon ESD. These recycle valves must have specific characteristics to cope with such fast transients and protect the compressor for undergoing surge. This paper describes three methods for determining the effectiveness of any specific recycle system and recycle valve characteristics. These three methods are: i) the concept of the Inertia number, ii) a simplified method based on system impedance, and iii) full dynamic simulation of the compression system. These three methods are applied to a high pressure ratio (up to 3.5) natural gas compressor station involving very high volume of piping and equipment contained within the recycle loop. There is a heat exchanger to utilize the heat of compression to heat the condensate separated downstream in the discharge scrubber, two large aerial coolers to cool the high temperature discharge gas from the compressor, and the discharge scrubber itself. This equipment and associated large volume capacitance contained therein presented a significant challenge and demand on the surge suppression system in all aspects of operation; particularly during ESD. Results are presented from all three methods which show the consistency and complementary nature of these methods.
Antibacterial Activities of the Cathelicidins Prophenin (Residues 62 to 79) and LL-37 in the Presence of a Lung Surfactant Preparation (2004)

The antibacterial activities of the cathelicidin peptides LL-37 and an 18-residue C-terminal fragment of prophenin, corresponding to positions 62 to 79 of native prophenin (PF-18), were analyzed in the presence of a modified surfactant preparation isolated from minced porcine lungs. At low micromolar concentrations, both LL-37 and PF-18 showed significant activities against different serotypes of group B streptococci, with LL-37 being more active on a molar basis. The surfactant preparation at a concentration of 10 mg/ml partly blocked the antibacterial activity of 9 microM LL-37 and completely blocked the antibacterial activity of 9 microM PF-18. However, 10 mg of the surfactant preparation per ml had only minor inhibitory effects on LL-37 and PF-18 at 90 microM. Addition of up to 900 microM PF-18 did not affect the surface properties of the surfactant preparation. These data suggest that surfactant preparations containing antimicrobial peptides could be useful for the local treatment of pulmonary infections.
A Combined Strategy to Improve the Development of a Coral Antivenom Against Micrurus spp. (2019)

Accidents involving <i>Micrurus</i> snakes are not the most common ones but are noteworthy due to their severity. Victims envenomed by <i>Micrurus</i> snakes are at high risk of death and therefore must be treated with coral antivenom. In Brazil, the immunization mixture used to fabricate coral antivenom contains <i>Micrurus frontalis</i> and <i>Micrurus corallinus</i> venoms, which are difficult to be obtained in adequate amounts. Different approaches to solve the venom limitation problem have been attempted, including the use of synthetic and recombinant antigens as substitutes. The present work proposes a combined immunization protocol, using priming doses of <i>M. frontalis</i> venom and booster doses of synthetic B-cell epitopes derived from <i>M. corallinus</i> toxins (four three-finger toxins-3FTX; and one phospholipase A<sub>2</sub>-PLA<sub>2</sub>) to obtain coral antivenom in a rabbit model. Immunized animals elicited a humoral response against both <i>M. frontalis</i> and <i>M. corallinus</i> venoms, as detected by sera reactivity in ELISA and Western Blot. Relevant cross-reactivity of the obtained sera with other <i>Micrurus</i> species (<i>Micrurus altirostris, Micrurus lemniscatus, Micrurus spixii, Micrurus surinamensis)</i> venoms was also observed. The elicited antibodies were able to neutralize PLA<sub>2</sub> activity of both <i>M. frontalis</i> and <i>M. corallinus</i> venoms. <i>In vivo</i>, immunized rabbit sera completely protected mice from a challenge with 1.5 median lethal dose (LD<sub>50</sub>) of <i>M. corallinus</i> venom and 50% of mice challenged with 1.5 LD<sub>50</sub> of <i>M. frontalis</i> venom. These results show that this combined protocol may be a suitable alternative to reduce the amount of venom used in coral antivenom production in Brazil.