gebhart/patrepeval huggingface dataset:
DNA Methylation in the Exon 1 Region and Complex Regulation of Twist1 Expression in Gastric Cancer Cells (2015)

Twist1 overexpression is frequently observed in various cancers including gastric cancer (GC). Although DNA methylation of the Twist1 gene has been reported in cancer cells, the mechanisms underlying transcriptional activation remain uncertain. In this study, we first examined epigenetic alterations of the Twist1 using Twist1 transcription-positive and -negative cell lines that are derived from our established diffuse-type GC mouse model. Treatment with a DNA demethylation agent 5-aza-dC re-activated Twist1 expression in Twist1 expression-negative GC cells. According to methylation-specific PCR and bisulfite sequencing analysis, methylation at the CpG-rich region within Twist1 coding exon 1, rather than its promoter region, was tightly linked to transcriptional silencing of the Twist1 expression in mouse GC cells. Chromatin immunoprecipitation assays revealed that active histone mark H3K4me3 was enriched in Twist1 expression-positive cells, and inactive histone mark H3K9me3 was enriched in Twist1 expression-negative cells. The expression levels of Suv39h1 and Suv39h2, histone methyltransferases for H3K9me3, were inversely correlated with Twist1 expression, and knockdown of Suv39h1 or Suv39h2 induced Twist1 expression. Moreover, Sp1 transcription factor bound to the exon 1 CpG-rich region in Twist1 expression-positive cell lines, and Twist1 expression was diminished by mithramycin, which that interferes with Sp1 binding to CpG-rich regulatory sequences. Our studies suggested that the Twist1 transcription in GC cells might be regulated through potential cooperation of DNA methylation, histone modification in complex with Sp1 binding to CpG-rich regions within the exon 1 region.
Exploration of Hydrogen Odorant for Fuel Cell Vehicles (2005)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
On the selection of single phase induction motors for low cost speed controlled drives (2009)

Operating single phase induction motors across a wide range of speed and load with high efficiency is still of interest. In the paper at hand the suitability of several different capacitor run single phase induction machines for Phase Control, Integral (Half) Cycle Control or Integral Switched Cycle Control is investigated. The induction machine's model's electrical and mechanical parameters are estimated and simulations are carried out in order to investigate the influence of the parameters on total input power, torque and losses. Measurements are carried out recording rotor speed and total input power comparing Phase Control and Integral Switched Cycle Control at approximately the same operating points. From these data a simple method is derived that can be used for selecting machines for low cost speed controlled drives. The experimental results verify the proposed method.
Can regulatory T cells improve outcomes of sensitised patients after HLA-Ab incompatible renal transplantation: study protocol for the Phase IIa GAMECHANgER-1 trial (2023)

EudraCT Number: 2021-001,664-23. REC Number: 21/SC/0253. Trial registration number ISRCTN14582152.
Kratos: Automated Management of Cooling Capacity in Data Centers With Adaptive Vent Tiles (2009)

In data centers with raised floor architecture, the floor tiles are typically perforated, delivering the cold air from the plenum to the inlets of equipment located in racks. The environment of these data centers is dynamic in that the workload and power dissipation fluctuate considerably over both short-term and long-term time scales. As such, airflow requirements vary continuously. However, due to labor costs and lack of expertise, the tiles are adjusted infrequently, and many data centers are grossly over provisioned for airflow in general and/or lack sufficient airflow delivery in certain local areas. This wastes energy and reduces data center thermal capacity. We have previously introduced Kratos, an Adaptive Vent Tile (AVT) technology that addresses this problem by automatically adjusting mechanical louvers mounted to the tiles in response to the needs of nearby IT equipment. Our initial results were limited to a 3-tile test bed that allowed us to prove concept but did not provide for scalability. This paper extends the previous work by expanding the size of the test bed to 28 tiles and 29 racks located in multiple thermal zones. We present experimental modeling results on the MIMO (Multi-Input Multi-Output) system and provide insights on the external behavior of the system through CFD (Computational Fluid Dynamic) analysis. We develop an MPC (Model-based Predictive Control) controller to maintain the temperatures of racks below the thresholds through vent tile tuning. Experimental results show that the controller can maintain the temperature below the thresholds while reducing overall cooling air requirements.
Glutamate in CNS Neurodegeneration and Cognition and its Regulation by GCPII Inhibition (2012)

Glutamate, first identified in 1866, is the primary excitatory neurotransmitter in the brain. While it is critically important in many highly regulated cortical functions such as learning and memory, glutamate can be much like the magic the Sorcerer's Apprentice used in Goethe's poem: when conjured under unregulated conditions glutamate can get quickly out of control and lead to deleterious consequences. Two broad types of glutamate receptors, the ionotropic and metabotropic, facilitate glutamatergic neurotransmission in the CNS and play key roles in regulating cognitive function. Excessive activation of these receptors leads to excitotoxicity, especially in brain regions that are developmentally and regionally vulnerable to this kind of injury. Dysregulation of glutamate signaling leads to neurodegeneration that plays a role in a number of neuropsychiatric diseases, prompting the development and utilization of novel strategies to balance the beneficial and deleterious potential of this important neurotransmitter. Inhibition of the enzyme glutamate carboxypeptidase II (GCPII) is one method of manipulating glutamate neurotransmission. Positive outcomes (decreased neuronal loss, improved cognition) have been demonstrated in preclinical models of ALS, stroke, and Multiple Sclerosis due to inhibition of GCPII, suggesting this method of glutamate regulation could serve as a therapeutic means for treating neurodegeneration and cognitive impairment.
Table S7 from The Lipogenic Regulator SREBP2 Induces Transferrin in Circulating Melanoma Cells and Suppresses Ferroptosis (2023)

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3D VSP: A useful tool for mining exploration. (2011)

The 3DVSP technique becomes more popular with the emergence of multilevel 3 component borehole tools. The value of the information derived from VSP is not always well understood. In this paper we will present a case history of a joint surface and borehole seismic acquisition, with the goal to derisk a shaft sinking location on a platinum mine. TD was about 650m and the VSP tool was 110m long. On surface a dense grid of receivers and vibrator source points were laid out in a 1.2 km radius circle centred on the well head. A12 level 3C VSP digital tool was lowered in the borehole, in three successive depth positions. The surface 3D cube was processed and interpreted independently from the 3D VSP data. On a near target reflector, the surface data structural interpretation showed mainly a clear E/W fault, and additional sub-seismic lineaments of differing azimuths, difficult to identify in terms of fault. The 3D VSP image limited to a short radius around the borehole confirmed the fault/dyke nature of these lineaments, separating monocline compartments. As a consequence, the surface data was carefully re-interpreted and on the second structural images derived from two surface seismic reflectors and the near surface fault footprint from 3DVSP residual statics, a series of subtle faults were clearly assessed. Last, the few faults intersecting the borehole can be clearly recognized on the logs and the borehole radar logs. This case study demonstrates the added value of a joint interpretation of surface and borehole data in a decision making process for shaft sinking.
Leveraging Domain Knowledge using Machine Learning for Image Compression in Internet-of-Things (2020)

The emergent ecosystems of intelligent edge devices in diverse Internet of Things (IoT) applications, from automatic surveillance to precision agriculture, increasingly rely on recording and processing variety of image data. Due to resource constraints, e.g., energy and communication bandwidth requirements, these applications require compressing the recorded images before transmission. For these applications, image compression commonly requires: (1) maintaining features for coarse-grain pattern recognition instead of the high-level details for human perception due to machine-to-machine communications; (2) high compression ratio that leads to improved energy and transmission efficiency; (3) large dynamic range of compression and an easy trade-off between compression factor and quality of reconstruction to accommodate a wide diversity of IoT applications as well as their time-varying energy/performance needs. To address these requirements, we propose, MAGIC, a novel machine learning (ML) guided image compression framework that judiciously sacrifices visual quality to achieve much higher compression when compared to traditional techniques, while maintaining accuracy for coarse-grained vision tasks. The central idea is to capture application-specific domain knowledge and efficiently utilize it in achieving high compression. We demonstrate that the MAGIC framework is configurable across a wide range of compression/quality and is capable of compressing beyond the standard quality factor limits of both JPEG 2000 and WebP. We perform experiments on representative IoT applications using two vision datasets and show up to 42.65x compression at similar accuracy with respect to the source. We highlight low variance in compression rate across images using our technique as compared to JPEG 2000 and WebP.
ChemInform Abstract: Reactions of Other Unsaturated Compounds; Reactions of Alkynes (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Dynamic Simulation Pericardial Bioprosthetic Heart Valve Function (2006)

While providing nearly trouble-free function for 10-12 years, current bioprosthetic heart valves (BHV) continue to suffer from limited long-term durability. This is usually a result of leaflet calcification and/or structural degeneration, which may be related to regions of stress concentration associated with complex leaflet deformations. In the current work, a dynamic three-dimensional finite element analysis of a pericardial BHV was performed with a recently developed FE implementation of the generalized nonlinear anisotropic Fung-type elastic constitutive model for pericardial BHV tissues (W. Sun and M.S. Sacks, 2005, [Biomech. Model. Mechanobiol., 4(2-3), pp. 190-199]). The pericardial BHV was subjected to time-varying physiological pressure loading to compute the deformation and stress distribution during the opening phase of the valve function. A dynamic sequence of the displacements revealed that the free edge of the leaflet reached the fully open position earlier and the belly region followed. Asymmetry was observed in the resulting displacement and stress distribution due to the fiber direction and the anisotropic characteristics of the Fung-type elastic constitutive material model. The computed stress distribution indicated relatively high magnitudes near the free edge of the leaflet with local bending deformation and subsequently at the leaflet attachment boundary. The maximum computed von Mises stress during the opening phase was 33.8 kPa. The dynamic analysis indicated that the free edge regions of the leaflets were subjected to significant flexural deformation that may potentially lead to structural degeneration after millions of cycles of valve function. The regions subjected to time varying flexural deformation and high stresses of the present study also correspond to regions of tissue valve calcification and structural failure reported from explanted valves. In addition, the present simulation also demonstrated the importance of including the bending component together with the in-plane material behavior of the leaflets towards physiologically realistic deformation of the leaflets. Dynamic simulations with experimentally determined leaflet material specification can be potentially used to modify the valve towards an optimal design to minimize regions of stress concentration and structural failure.
Low-lying excited states in the neutron-deficient isotopes163Os and165Os (2013)

Excited states in the neutron-deficient isotopes ${}^{163}$Os and ${}^{165}$Os were identified using the JUROGAM and GREAT spectrometers in conjunction with the RITU gas-filled separator. The ${}^{163}$Os and ${}^{165}$Os nuclei were populated via the ${}^{106}$Cd(${}^{60}$Ni,3$n$) and ${}^{92}$Mo(${}^{78}$Kr,2$p$3$n$) reactions at bombarding energies of 270 MeV and 357 MeV, respectively. Gamma-ray emissions from these nuclei have been established unambiguously using the recoil-decay tagging technique and a coincidence analysis has allowed level schemes to be established. These results suggest that the yrast states are based upon negative-parity configurations originating from the $\ensuremath{\nu}$${f}_{7/2}$ and $\ensuremath{\nu}$${h}_{9/2}$ orbitals.
Androgens and breast cancer (1990)

We have recently demonstrated that physiological levels of androgens exert direct and potent inhibitory effects on the growth of human breast cancer ZR-75-1 cells in vivo in nude mice as well as in vitro under both basal and estrogen-stimulated conditions. The inhibitory effect of androgens has also been confirmed on the growth of dimethylbenz(a)anthracene (DMBA)-induced mammary carcinoma in the rat. Such observations are in close agreement with the clinical data showing that androgens and the androgenic compound medroxyprogesterone acetate (MPA) have beneficial effects in breast cancer in women comparable to other endocrine therapies, including tamoxifen. Although the inhibitory action of androgens on cell proliferation in estrogen-induced ZR-75-1 cells results, in part, from their suppressive effect on expression of the estrogen receptor, the androgens also exert a direct inhibitory effect independent of estrogens. Androgens cause a global slowing effect on the duration of the cell cycle. These observations support clinical data showing that androgenic compounds induce an objective remission after failure of antiestrogen therapy as well as those indicating that the antiproliferative action of androgens is additive to that of antiestrogens. We have also recently demonstrated in ZR-75-1 human breast cancer cells the antagonism between androgens and estrogens on the expression of GCDFP-15 and GCDFP-24 which are two major proteins secreted in human gross cystic disease fluid. The effects of androgens and estrogens as well as those of progestins and glucocorticoids on GCDFP-15 and GCDFP-24 mRNA levels and secretion are opposite to those induced by the same steroids on cell growth in ZR-75-1 cells.
Geometrically Invariant Image Watermarking via Robust Perceptual Hashes (2006)

We consider the problem of blind watermark detection from an image, when the image has undergone a geometric attack. Existing schemes for solving this problem involve insertion of periodic marks or templates, invariant properties of transforms, and feature point based techniques. A major deficiency of these approaches is either a security leak (owing to redundancy in the mark) and/or poor watermark detection performance esp. under lossy geometric attacks, e.g. cropping. In this paper, we introduce a novel watermark synchronization paradigm by using perceptual image hashes. We exploit the fact that a perceptual hash acts as a robust as well as randomized digest of image content, and use it to embed a synchronization mark into the image. Unlike existing synchronization schemes, our synchronization mark has favorable security and robustness to adversarial attacks and hence, cannot be easily removed. Experimental results confirm that our proposed algorithm has significantly lower watermark detection error probabilities than existing methods.
Ynol Ethers as Ketene Equivalents in Rhodium-Catalyzed Intermolecular [5 + 2] Cycloaddition Reactions (2017)

The previously unexplored metal-catalyzed [5 + 2] cycloadditions of vinylcyclopropanes (VCPs) and electron-rich alkynes (ynol ethers) have been found to provide a highly efficient, direct route to dioxygenated seven-membered rings, a common feature of numerous natural and non-natural targets and building blocks for synthesis. The reactions proceed in high yield at room temperature and tolerate a broad range of functionalities. Substituted VCPs were found to react with high regioselectivity.
Expression, purification, crystallization and preliminary X-ray diffraction studies of human liver regucalcin (2004)

Regucalcin is a novel calcium ion (Ca2+) binding protein that does not contain an EF-hand motif as a Ca2+-binding domain and has been demonstrated to play a multi-functional role in many cell types. Human liver regucalcin, consisting of 299 amino-acid residues, was overexpressed in Escherichia coli, purified and crystallized by the vapour-diffusion method in the presence of polyethylene glycol 4000 as a precipitant. A native crystal diffracted to 2.8 Å with synchrotron radiation and belongs to space group P21, with unit-cell parameters a = 64.87, b = 52.52, c = 86.38 Å, β = 99.86°. Two molecules most probably exist in the asymmetric unit, corresponding to VM = 2.2 Å3 Da−1. Heavy-atom derivative data were collected and the Pb derivative showed one high-occupancy site per molecule.
A tungsten T-shaped methylene complex and related methylidyne hydride complexes (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA tungsten T-shaped methylene complex and related methylidyne hydride complexesSteven J. Holmes and Richard R. SchrockCite this: J. Am. Chem. Soc. 1981, 103, 15, 4599–4600Publication Date (Print):July 1, 1981Publication History Published online1 May 2002Published inissue 1 July 1981https://pubs.acs.org/doi/10.1021/ja00405a060https://doi.org/10.1021/ja00405a060research-articleACS PublicationsRequest reuse permissionsArticle Views271Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Interactions between Conserved Residues in Transmembrane Helices 2 and 7 during Angiotensin AT1 Receptor Activation (2006)

Site-directed mutagenesis studies and independent molecular modeling studies were combined to investigate the network of inter-residue interactions within the transmembrane region of the angiotensin AT(1a) receptor. Site-directed mutagenesis was focused on residues Tyr292, Asn294, Asn295, and Asn298 in transmembrane helix 7, and the conserved Asp74 in helix 2 and other polar residues. Functional interactions between pairs of residues were evaluated by determining the effects of single and double-reciprocal mutations on agonist-induced AT(1a) receptor activation. Replacement of Tyr292 by aspartate in helix 7 abolished radioligand binding to both Y292D and D74Y/Y292D mutant receptors. Reciprocal mutations of Asp74/Asn294, Ser115/Asn294, Ser252/Asn294, and Asn298/Sen115 caused additive impairment of function, suggesting that these pairs of residues make independent contributions to AT(1a) receptor activation. In contrast, mutations of the Asp74/Tyr298 pair revealed that the D74N/N298D reciprocal mutation substantially increased the impaired inositol phosphate responses of the D74N and N298D receptors. Extensive molecular modeling yielded 3D models of the TM region of the AT(1) receptor and the mutants as well as of their complexes with angiotensin II, which were used to rationalize the possible reasons of impairing of function of some mutants. These data indicate that Asp74 and Asn298 are not optimally positioned for direct strong interaction in the resting conformation of the AT(1a) receptor. Balance of interactions between residues in helix 2 (as D74) and helix 7 (as N294, N295 and N298) in the AT(1) receptors, however, has a crucial role both in determining their functional activity and levels of their expression.
Integrated Piezoelectric AlN Thin Film with SU-8/PDMS Supporting Layer for Flexible Sensor Array (2020)

This research focuses on the development of a flexible tactile sensor array consisting of aluminum nitride (AlN) based on micro-electro-mechanical system (MEMS) technology. A total of 2304 tactile sensors were integrated into a small area of 2.5 × 2.5 cm<sup>2</sup>. Five hundred nm thick AlN film with strong c-axis texture was sputtered on Cr/Au/Cr (50/50/5 nm) layers as the sacrificial layer coated on a Si wafer. To achieve device flexibility, polydimethylsiloxane (PDMS) polymer and SU-8 photoresist layer were used as the supporting layers after etching away a release layer. Twenty-five mM (3-mercaptopropyl) trimethoxysilane (MPTMS) improves the adhesion between metal and polymers due to formation of a self-assembled monolayer (SAM) on the surface of the top electrode. The flexible tactile sensor has 8 × 8 channels and each channel has 36 sensor elements with nine SU-8 bump blocks. The tactile sensor array was demonstrated to be flexible by bending 90 degrees. The tactile sensor array was demonstrated to show clear spatial resolution through detecting the distinct electrical response of each channel under local mechanical stimulus.
"Tabulation of the Symbolic Midframe Jacobian of a Robot Manipulator" by Keith L. Doty (1990)

Commentaire sur «la tabulation du Jacobien a mi-structure symbolique d'un robot manipulateur» propose par Keith L. Doty (1987). Les corrections necessaires sont proposees
Parameter Optimisation for Ultra-Wideband Optical Networks in the Presence of Stimulated Raman Scattering Effect (2021)

This paper studies the effects of channel launch power and topology parameters on performance for ultra-wideband optical networks in the presence of stimulated Raman scattering (SRS). Results exhibit significant throughput improvements for optimised per-channel launch power allocation over conventional uniform power allocation. Furthermore, the impact of network structural features on performance is investigated and a significant increase in throughput and a reduction in fibre installation cost are achieved by optimising network topology for two real world core networks.