gebhart/patrepeval huggingface dataset:
High-speed operation of a 64-bit circular shift register (1998)

A 64-bit superconducting rapid single flux quantum (RSFQ) circular shift register (CSR) has been demonstrated to operate at clock frequencies up to 18 GHz. The CSR was designed with special attention to timing constraints, which are more severe for "recurrent" circuits (where data must circulate around closed feedback loops) than for systolic arrays where only local timing constraints are relevant. The longest recurrent data path ever demonstrated previously was only several stages long. The testing scheme demonstrated here is unique in that the data circulated up to 50 million times before verification.
Integrating genomics and phylogenetics in understanding the history of Trichinella species (2008)

In 2004, funding was received by Washington University's Genome Sequencing Center through NHGRI, to completely sequence several nematode genomes as part of a holistic effort to advance our understanding of the human genome and evolution within the Metazoa. Trichinella spiralis was among this group of worms because of its strategic location at the base of the phylum Nematoda, and the belief that extant species represented an ancient divergent event that occurred as early as the Paleozoic. At the same time, a concerted effort was put forth to solidify the phylogeny of extant species of Trichinella based upon molecular analyses of a multi-gene system to understand the history of the genus and thereby enhance utilization of the forthcoming sequence data. Since the inception of this research, several findings have emerged: (1) the size of T. spiralis genome estimated by flow cytometry (71.3 Mb) is substantially smaller than originally predicted (270 Mb); (2) to date, a subset of the total of 3,534,683 sequences have been assembled into a 59.3 Mb unique sequence; (3) 19% of the assembled sequence is comprised of repetitive elements; and (4) sequence data are predicated upon extant T. spiralis which probably diverged as little as 20 million years ago. Thus, the utility of the T. spiralis genome as representative of an archaic species must be tempered with the knowledge that encapsulated and non-encapsulated clades probably separated during the mid-Miocene as temperate ecosystems changed.
Association of Childhood Obesity With Atopic and Nonatopic Asthma: Results From the National Health and Nutrition Examination Survey 1999–2006 (2010)

Excess weight in children is associated with higher rates of asthma, especially asthma that is not accompanied by allergic disease.
Development of a Bacillus subtilis -Based Rotavirus Vaccine (2010)

Bacillus subtilis vaccine strains engineered to express either group A bovine or murine rotavirus VP6 were tested in adult mice for their ability to induce immune responses and provide protection against rotavirus challenge. Mice were inoculated intranasally with spores or vegetative cells of the recombinant strains of B. subtilis. To enhance mucosal immunity, whole cholera toxin (CT) or a mutant form (R192G) of Escherichia coli heat-labile toxin (mLT) were included as adjuvants. To evaluate vaccine efficacy, the immunized mice were challenged orally with EDIM EW murine rotavirus and monitored daily for 7 days for virus shedding in feces. Mice immunized with either VP6 spore or VP6 vegetative cell vaccines raised serum anti-VP6 IgG enzyme-linked immunosorbent assay (ELISA) titers, whereas only the VP6 spore vaccines generated fecal anti-VP6 IgA ELISA titers. Mice in groups that were immunized with VP6 spore vaccines plus CT or mLT showed significant reductions in virus shedding, whereas the groups of mice immunized with VP6 vegetative cell vaccines showed no difference in virus shedding compared with mice immunized with control spores or cells. These results demonstrate that intranasal inoculation with B. subtilis spore-based rotavirus vaccines is effective in generating protective immunity against rotavirus challenge in mice.
Discovery ofN-[(4R)-6-(4-Chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-carboxamide (MK-5596) as a Novel Cannabinoid-1 Receptor (CB1R) Inverse Agonist for the Treatment of Obesity (2010)

This paper describes the discovery of N-[(4R)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-carboxamide (MK-5596, 12c) as a novel cannabinoid-1 receptor (CB1R) inverse agonist for the treatment of obesity. Structure-activity relationship (SAR) studies of lead compound 3, which had off-target hERG (human ether-a-go-go related gene) inhibition activity, led to the identification of several compounds that not only had attenuated hERG inhibition activity but also were subject to glucuronidation in vitro providing the potential for multiple metabolic clearance pathways. Among them, pyrazole 12c was found to be a highly selective CB1R inverse agonist that reduced body weight and food intake in a DIO (diet-induced obese) rat model through a CB1R-mediated mechanism. Although 12c was a substrate of P-glycoprotein (P-gp) transporter, its high in vivo efficacy in rodents, good pharmacokinetic properties in preclinical species, good safety margins, and its potential for a balanced metabolism profile in man allowed for the further evaluation of this compound in the clinic.
Nanocrystalline ceria imparts better high–temperature protection (2004)

Nanomaterials have attracted considerable interest with numerous technological developments in the last decade. Nanomaterials exhibit different physicochemical properties compared with their bulk counterparts because the diameters of the nanoparticles are less than the Bohr exciton radius. Cerium oxide based materials have been extensively studied for various technological applications. In the present study, the application of nanocrystalline cerium oxide for improvement of high–temperature–oxidation resistance of stainless steel has been studied. The role of coating of nanocrystalline cerium oxide towards improvement of high–temperature–oxidation resistance has been investigated and compared with that of the micrometre–sized cerium oxide particles. It was observed that nanocrystalline ceria improved high–temperature–oxidation resistance of AISI 304 stainless steel to a large extent compared with the micrometre–sized ceria coating. Nanocrystalline ceria coating decreased the isothermal parabolic rate constant of oxidation by more than two orders of magnitude compared with that of the bare alloy. The resistance to oxide scale spallation was also found to improve with the coating of cerium oxide nanoparticles.Secondary ion mass spectroscopy (SIMS) study of nanocrystalline ceria–coated and oxidized specimens revealed the presence of nanoceria at the outermost oxide surface, indicating a change in the oxide scale growth mechanism from outward cation diffusion to inward oxygen diffusion in the bare alloy at high temperature in dry air. The oxide scale morphology was studied using a scanning electron microscope (SEM) while a focused ion beam (FIB) technique was used to study the oxide–alloy interface. X–ray photoelectron spectroscopy (XPS) study of nanocrystalline ceria showed the presence of Ce3+ and Ce4+ oxidation states. It is proposed that the presence of the Ce3+ oxidation state in nanocrystalline ceria improves the oxidation resistance of stainless steel, and the related mechanisms are discussed.
Measuring bidirectional texture reflectance with a kaleidoscope (2003)

We describe a new technique for measuring the bidirectional texture function (BTF) of a surface that requires no mechanical movement, can measure surfaces in situ under arbitrary lighting conditions, and can be made small, portable and inexpensive. The enabling innovation is the use of a tapered kaleidoscope, which allows a camera to view the same surface sample simultaneously from many directions. Similarly, the surface can be simultaneously illuminated from many directions, using only a single structured light source. We describe the techniques of construction and measurement, and we show experimental results.
Portal Vein Glucose Entry Triggers a Coordinated Cellular Response That Potentiates Hepatic Glucose Uptake and Storage in Normal but Not High-Fat/High-Fructose–Fed Dogs (2012)

The cellular events mediating the pleiotropic actions of portal vein glucose (PoG) delivery on hepatic glucose disposition have not been clearly defined. Likewise, the molecular defects associated with postprandial hyperglycemia and impaired hepatic glucose uptake (HGU) following consumption of a high-fat, high-fructose diet (HFFD) are unknown. Our goal was to identify hepatocellular changes elicited by hyperinsulinemia, hyperglycemia, and PoG signaling in normal chow-fed (CTR) and HFFD-fed dogs. In CTR dogs, we demonstrated that PoG infusion in the presence of hyperinsulinemia and hyperglycemia triggered an increase in the activity of hepatic glucokinase (GK) and glycogen synthase (GS), which occurred in association with further augmentation in HGU and glycogen synthesis (GSYN) in vivo. In contrast, 4 weeks of HFFD feeding markedly reduced GK protein content and impaired the activation of GS in association with diminished HGU and GSYN in vivo. Furthermore, the enzymatic changes associated with PoG sensing in chow-fed animals were abolished in HFFD-fed animals, consistent with loss of the stimulatory effects of PoG delivery. These data reveal new insight into the molecular physiology of the portal glucose signaling mechanism under normal conditions and to the pathophysiology of aberrant postprandial hepatic glucose disposition evident under a diet-induced glucose-intolerant condition.
In vitro induction of continuous acute promyelocytic leukemia cell lines by Friend or Abelson murine leukemia virus (1979)

S INCE THEIR DISCOVERY in the 1950s’ the murine type-C RNA leukemia viruses (retroviruses) have been intensively studied as model etiologic agents for human leukemia.2’3 The biochemical mechanism for replication and integration ofviral genetic sequences into host cell DNA has been partially elucidated,3 and the proviral DNA sequences for multiple copies of leukemogenic viral genomes have been detected by sensitive molecular biologic techniques in the DNA of mouse embryo cells.3’4 Both virus-specific and host-specific genetic factors are known to be very important for leukemogenesis in vivo.”3 The recent discovery of vertically transmitted (“inherited”) viral genomes that can be induced to produce a distinct class of xenotropic viruses incapable of growth in host cells has uncovered new variables for analysis of why some viruses cause leukemia and others do not.5 In vivo studies of the cellular biology of virus-induced leukemias have been complicated by several variables: the host’s immune response to the virus, which may contribute to or even provide the target cells for transformation;6’7 the presence
Adaptive and Flexible Model-Based AI for Deep Receivers in Dynamic Channels (2023)

Artificial intelligence (AI) is envisioned to play a key role in future wireless technologies, with deep neural networks (DNNs) enabling digital receivers to learn to operate in challenging communication scenarios. However, wireless receiver design poses unique challenges that fundamentally differ from those encountered in traditional deep learning domains. The main challenges arise from the limited power and computational resources of wireless devices, as well as from the dynamic nature of wireless communications, which causes continual changes to the data distribution. These challenges impair conventional AI based on highly-parameterized DNNs, motivating the development of adaptive, flexible, and light-weight AI for wireless communications, which is the focus of this article. Here, we propose that AI-based design of wireless receivers requires rethinking of the three main pillars of AI: architecture, data, and training algorithms. In terms of architecture, we review how to design compact DNNs via model-based deep learning. Then, we discuss how to acquire training data for deep receivers without compromising spectral efficiency. Finally, we review efficient, reliable, and robust training algorithms via meta-learning and generalized Bayesian learning. Numerical results are presented to demonstrate the complementary effectiveness of each of the surveyed methods. We conclude by presenting opportunities for future research on the development of practical deep receivers
Murine spontaneous T‐cell leukemia constitutively expressing IL‐2 receptor—a model for human T‐cell malignancies expressing IL‐2 receptor (1990)

We describe a new, spontaneously occurring BALB/c-derived murine T-cell leukemia. The leukemic cells, designated LB, grow rapidly and progressively in the syngeneic host with no signs of effective immunological resistance. LB cells expressed the Thy-1+, Lyt-2+, L3T4-, CD3- class-I+, CD25+ (IL-2 receptor, IL-2R), class-II-, gp70- phenotype. As LB cells express IL-2, as indicated by staining with 2 distinct anti-CD25 IL-2R monoclonal antibodies (MAbs), the therapeutic efficacy of IL-2-diphtheria toxin-related protein was tested on this leukemic model. IL-2-diphtheria toxin, but not diphtheria toxin, efficiently inhibited the proliferation of LB cells. The proliferation of a murine myeloma cell line, which does not express IL-2R, was not inhibited by IL-2-diphtheria toxin. The possible implantation of this animal model in fundamental and practical studies is discussed.
Electron relaxation and transport dynamics in low-temperature-grown GaAs under 1 eV optical excitation (2003)

Electron relaxation and transport dynamics in low-temperature-grown GaAs under 1 eV optical excitation was investigated by femtosecond transient transmission measurement and electro-optical sampling measurement in bulk samples and fabricated devices. An increase in the electron lifetime can be observed when the electron density is higher than 3×1017 cm−3. This effect is attributed to prolonged electron relaxation due to intervalley scattering of highly excited electrons and associated hot phonon effects. Our conclusion is further supported by bias-dependent studies where intervalley scattering was achieved using high electric fields.
Intel® Xeon Phi coprocessor (codename Knights Corner) (2012)

This article consists of a collection of slides from the author's conference presentation on Intel's Xeon Phi (Knights Corner] coprocessor. Some of the specific topics discussed include: the special features and applications supported by Xeon Phi; Intel's integrated core architecture; coprocessor system specifications and architecture; memory management; media streaming capabilities; and system performance evaluations.
Design and Development of Fluorescent Vemurafenib Analogs for In Vivo Imaging (2017)

Herein we describe fluorescent derivatives of vemurafenib to probe therapeutic BRAF inhibition in live cells and <i>in vivo</i>. The compounds were evaluated and compared by determining target binding, inhibition of mutant BRAF melanoma cell lines and live cell imaging. We show that vemurafenib-BODIPY is a superior imaging drug to visualize the targets of vemurafenib in live cells and <i>in vivo</i> in non-resistant and resistant melanoma tumors.
Involvement of Cell Proliferation Induced by Dual Intracellular Signaling of HB-EGF in the Development of Colitis-Associated Cancer during Ulcerative Colitis (2010)

In ulcerative colitis (UC), the duration and severity of inflammation are responsible for the development of colorectal cancer. Reactive oxygen species (ROS), reactive nitric metabolites (RNMs) and interleukin (IL)-8, released by epithelial and immune cells, are involved in the pathogenesis of colitis-associated cancer. Nitric oxide and peroxynitrite activate epidermal growth factor receptor (EGFR), and therapeutic agents targeted towards EGFR are currently used to treat advanced colorectal cancer. IL-8 (a G-protein coupled receptor (GPCR) agonist), which is involved in neutrophil recruitment and activation in persistent active colitis, also promotes cleavage of the proheparin-binding epidermal growth factor-like growth factor (proHB-EGF) through a disintegrin and metalloproteinase (ADAM). The cleaved HB-EGF and C-terminal fragments (intracellular CTF) regulate proliferation via EGFR activation and nuclear export of promyelocytic leukemia zinc finger, transcription repressor, respectively. Here, we focus on the mechanisms by which RNM- and IL-8-induced EGF signaling regulate cell proliferation during the development of colitis-associated cancer.
Regenerable MgO-Based SOx Removal Sorbents Promoted with Cerium and Iron Oxide in RFCC (2005)

The aims of this work were verifying the roles of various promoters in absorption and regeneration. In particular, we focus our attention on the oxidation properties of Ce, Co, and Fe and regeneration property of Fe of the MgO-based sorbents. The MgO-based SO2 sorbents promoted with Ce, Co, Fe, and Cu were developed for use in RFCC and FCC units. Their ability for SO2 absorption as well as regeneration was investigated in a fixed-bed reactor under RFCC and FCC reaction conditions. The promoters played an important role in transforming SO2 into SO3, which could be easily absorbed into MgO. Their oxidation ability increased in the following order Fe < Co < Ce. In addition, their reuse through the regeneration of sorbents with hydrogen in a FCC unit depended on these promoters. In particular, the MgO sorbent which was promoted simultaneously with Ce and Fe showed excellent characteristics in SO2 removal and regeneration in that this material satisfies the requirements of a large amount of SO2 absorption (ads. sulfur g/g sorbent) along with fast and complete regeneration under mild condition (1 atm, 530 °C).
Purification, crystallization and preliminary X-ray crystallographic analysis of ST1022, a putative member of the Lrp/AsnC family of transcriptional regulators isolated fromSulfolobus tokodaiistrain 7 (2007)

The Lrp/AsnC family of transcriptional regulators, also known as feast/famine transcriptional regulators, are widely distributed among bacteria and archaea. This family of proteins are likely to be involved in cellular metabolism, with exogenous amino acids functioning as effectors. Here, the crystallization and preliminary X-ray diffraction analysis of ST1022, a member of the Lrp/AsnC family of proteins, is reported with and without exogenous glutamine as the effector molecule. The crystals of native ST1022 and of the putative complex belong to the tetragonal space group I422, with unit-cell parameters a = b = 103.771, c = 73.297 A and a = b = 103.846, c = 73.992 A, respectively. Preliminary X-ray diffraction data analysis and molecular-replacement solution revealed the presence of one monomer per asymmetric unit.
Development of a Conditional Replication Competent Adenovirus, Controlled by the Human Telomerase Promoter (hTERT) (2003)

S: The use of m-hTERT promoter is not only useful in the regulation of therapeutic gene expression but also that replication-competent oncolytic adenovirus under the control of m-hTERT promoter may be a new promising tool for the treatment of human malignancies.
An FPGA-based stereoscopic camera - electronic design tools and techniques (2010)

Electronic design tools and techniques for the implementation of a stereoscopic camera based on an FPGA (Field Programmable Gate Array) are presented. The stages of an IPP (Image Processing Pipeline) are presented together with the development tools and languages used to implement a stereoscopic camera in hardware. In a further development of the basic system, aspects of the implementation of a 3D camera are presented.
Psychometric Impact of Priapism on Lives of Adolescents and Adults With Sickle Cell Anemia: A Sequential Independent Mixed-Methods Design (2021)

Despite priapism being one of the most frequent complications of sickle cell anemia (SCA) in male individuals, little has been reported about the impact of priapism in this population. The authors used a sequential independent mixed-methods design, which used both international multicenter focus group discussions (n=35) and a quantitative patient-reported outcome measure (n=131) to determine the impact of priapism on men with SCA in Nigeria and the United States. The authors analyzed data from focus groups using an iterative inductive-deductive approach. Comparison of the Priapism Impact Profile data was done using the Kruskal-Wallis H test. Our result showed that priapism, across cultures, is associated with shame and embarrassment. These emotions interfere with timely clinical and family communication about priapism symptoms and complications. Participants were dissatisfied with the quality of care at emergency facilities. The quality of life and physical wellness of men with SCA-related priapism were significantly different for the 3 groups: (1) priapism condition getting better, (2) priapism condition getting worse, and (3) priapism condition remain the same ( P =0.002 and P =0.019, respectively). Psychological, sexual, and physical wellbeing are all adversely affected by priapism. Evidence-based methods are necessary for adequate medical, educational, and psychological treatment for recurrent priapism.
The molecular mechanism by which saturated lysophosphatidylcholine attenuates the metastatic capacity of melanoma cells (2016)

Lysophophatidylcholine (LysoPC) is an abundant constituent in human plasma. Patients with malignant cancer diseases have attenuated LysoPC plasma levels, and thus LysoPC has been examined as a metabolic biomarker for cancer prediction. Preclinical studies have shown that solid tumor cells drastically degrade LysoPCs by incorporating their free fatty acids into cell membrane phospholipids. In this way, LysoPC C18:0 reduced the metastatic spread of murine melanoma B16.F10 cells in mice. Although membrane rigidification may have a key role in the attenuation of metastasis, evidence for this has yet to be shown. Therefore, the present study aimed to determine how LysoPC reduces the metastatic capacity of B16.F10 cells. Following cellular preincubation with LysoPC C18:0 at increasing concentrations and lengths of time, cell migration was most significantly attenuated with 450 μm LysoPC C18:0 at 72 h. Biosensor measurements suggest that, despite their abundance in B16.F10 cells, LysoPC-sensitive G protein-coupled receptors do not appear to contribute to this effect. Instead, the attenuated migration appears to result from changes in cell membrane properties and their effect on underlying signaling pathways, most likely the formation of focal adhesion complexes. Treatment with 450 μm LysoPC C18:0 activates protein kinase C (PKC)δ to phosphorylate syndecan-4, accompanied by deactivation of PKCα. Subsequently, focal adhesion complex formation was attenuated, as confirmed by the reduced activity of focal adhesion kinase (FAK). Interestingly, 450 μm LysoPC C18:1 did not affect FAK activity, explaining its lower propensity to affect migration and metastasis. Therefore, membrane rigidification by LysoPC C18:0 appears to prevent the formation of focal adhesion complexes, thus affecting integrin activity as a key for metastatic melanoma spread.