gebhart/patrepeval huggingface dataset:
Stereoselective aldol coupling of cobalt-complexed alkynyl aldehydes (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereoselective aldol coupling of cobalt-complexed alkynyl aldehydesJingyue Ju, B. R. Reddy, Masood Khan, and Kenneth M. NicholasCite this: J. Org. Chem. 1989, 54, 23, 5426–5428Publication Date (Print):November 1, 1989Publication History Published online1 May 2002Published inissue 1 November 1989https://pubs.acs.org/doi/10.1021/jo00284a010https://doi.org/10.1021/jo00284a010research-articleACS PublicationsRequest reuse permissionsArticle Views239Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Pictorial space perception and viewing distance (2004)

We rarely view pictures from their original projective distance, i.e. from the center of projection (CoP). Nonetheless, the scene perceived from a picture seems to be like the depicted scene. Why does pictorial scene perception seem resistant to changes in viewing distance? The retinal image is altered by changing viewing distance. Thus, if the viewer only used the retinal image associated with a surface in the picture, the surface slant would be misperceived when viewed from the wrong distance. For example, slant would be overestimated when viewing from farther than the CoP. The pictorial-compensation hypothesis (e.g. Kubovy, 1986; Sedgwick, 1980) states how viewers might compensate for incorrect distance. Pictorial cues (e.g. rectilinear structure in the depicted scene) locate the CoP and then used to effectively transport the viewer to the correct position. The compensation hypothesis thus predicts that surface slant would not be overestimated when viewing from farther than the CoP. We trained observers to judge the slant of an upright rectangle in a scene rich with pictorial cues. They made judgments at different distances (including the CoP distance) with monocular and binocular viewing. The visual angle of the stimulus was constant across viewing distance. With both monocular and binocular viewing, slant was estimated correctly at the CoP distance and was overestimated at longer distances. Thus, we found no evidence for the pictorial-compensation hypothesis, even when the picture contained rich pictorial information and the distance to the picture was specified by binocular disparity. DOE CSGF (for ARG), NIH NRSA (for DV)
Intra-ion-pair Electron Transfer Mechanism for Photolysis of Diphenyliodonium Salt Sensitized by 9,10-Dmethoxyanthracene-2-sulfonate Counteranion (1991)

Abstract Diphenyliodonium 9,10-dimethoxyanthracene-2-sulfonate is photochemically dissociated to give 9,10-dimethoxyanthracene-2-sulfonic acid. The dissociation is considered to proceed via an intra-ion-pair electron transfer from 9,10-dimethoxyanthracene moiety to iodonium moiety. The counteranion acts as both spectral sensitizer for diphenyliodonium ion and precursor for photo-acid generator.
A Dual-Enzyme Hydrogen Peroxide Generation Machinery in Hydrogels Supports Antimicrobial Wound Treatment (2017)

The aging population and accompanying diseases like diabetes resulted in an increased occurrence of chronic wounds. Topical wound treatment with antimicrobial agents to inhibit bacterial invasion and promote wound healing is often associated with difficulties. Here, we investigated the potential of succinyl chitosan (SC)-carboxymethyl cellulose (CMC) hydrogels which constantly release clinically relevant levels of hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>). CMC hydrogel matrix was in situ converted by limited hydrolysis by a cellulase into substrates accepted by cellobiose dehydrogenase (CDH) for continuous production of H<sub>2</sub>O<sub>2</sub> (30 μM over 24 h). This dual-enzyme catalyzed in situ H<sub>2</sub>O<sub>2</sub> generation system proved its antimicrobial activity in a zone of inhibition (ZOI) assay best simulating the application as wound dressing and was found to be biocompatible toward mouse fibroblasts (95% viability). The hydrogels were thoroughly characterized regarding their rheological properties indicating fast gel formation (<3 min) and moderate cross-linking (1.5% strain, G' = 10 Pa). Cooling (fridge conditions) was found to be the simple on/off switch of the enzymatic machinery which is of great importance regarding storage and applicability of the bioactive hydrogel. This robust and bioactive antimicrobial hydrogel system overcomes dosing issues of common topical wound treatments and constitutes a promising wound healing approach for the future.
Low Temperature Effects on Development, Mortality, Fecundity, and Viability of the Ectoparasitoid Catolaccus grandis (Hymenoptera: Pteromalidae)1 (1996)

The low temperature threshold for development of Catolaccus grandis (Burks) was 12°C for eggs, 11.5°C for larvae, and 9.5°C for pupae. The developmental time for male or female parasitoids increased by 4.6 to 5.3 times and the preovipositional period of females increased from 2.2 to 9.3 days when the temperature was reduced from 30°C to 15°C. The number of degree-days to complete development was 225.6 for females and 197.2 for males. The mean duration of emergence for C. grandis ranged from 2.6 days at 27°C - 30°C to 5.7 days at 20°C. Reduction of the temperature from 25°C to 15°C increased the death rate of C. grandis 2.3 times and reduced emergence of parasitoid females by 77.8%. The percentage of emergence of females from pupae with the black thorax-yellow abdomen held at temperatures lower than 15°C for 20 days or more and pupae with yellow color held at 5°C for 10 or more days decreased significantly compared with females from pupae held at 25°C. Storage of pupae at 20°C or lower resulted in adult females with reduced fecundity. However, the sex ratio of the progeny was not significantly affected.
Phenotype and Clinical Outcomes of Titin Cardiomyopathy (2017)

In this large, prospective, genotype-phenotype study of ambulatory DCM patients, we show that prognostic factors for all-cause DCM also predict outcome in TTNtv DCM, and that TTNtv DCM does not appear to be associated with worse medium-term prognosis.
Transforming growth factor β1 polymorphisms and progression of graft fibrosis after liver transplantation for hepatitis C virus--induced liver disease (2010)

Re-infection with the hepatitis C virus (HCV) is an important development after liver transplantation (LT); it can lead to graft fibrosis. The aim of this study was to assess the role of transforming growth factor β1 (TGF-β1) polymorphisms in the development of HCV-related graft disease by evaluating protocol liver biopsies. A total of 192 patients with a recurrence of HCV infection after LT were genotyped for TGF-β1 codon 10 (C→T) and codon 25 (G→C) using the polymerase chain reaction. Histological evaluation of 614 protocol liver biopsies obtained from these patients was undertaken using the classification of Desmet and Scheuer to stage the degree of fibrosis. Mild stages of fibrosis (0-2) were compared to advanced stages of fibrosis (3-4) that developed during the period of infection with the virus. Correlations between the prevalence of TGF-β1 genotypes and the different degrees of fibrosis that developed were determined. No statistically significant differences were found for genotype distributions (codons 10 and 25) with respect to recipient age, donor sex, occurrence of acute cellular rejection, and response to antiviral therapy. However, the C allele at codon 25 was significantly less frequent in the group with advanced fibrosis (P = 0.001). Furthermore, a positive association was found between progression of fibrosis and male recipient sex (P = 0.024), donor age (P = 0.041), and viral genotype 1b (P = 0.002). In conclusion, this study, in which the evolution of hepatic fibrosis was assessed histologically in a large cohort of patients with HCV re-infection after LT, has demonstrated that the C allele at codon 25 of the TGF-β1 gene is a marker for the development of graft fibrosis.
Proof search in first-order linear logic and other cut-free sequent calculi (2002)

We present a general framework for proof search in first-order cut-free sequent calculi and apply it to the specific case of linear logic. In this framework, Herbrand functions are used to encode universal quantification, and unification is used to instantiate existential quantifiers so that the eigenvariable conditions are respected. We present an optimization of this procedure that exploits the permutabilities of the subject logic. We prove the soundness and completeness of several related proof search procedures. This proof search framework is used to show that provability for first-order MALL is in NEXPTIME, and first-order MLL is in NP. Performance comparisons based on Prolog implementations of the procedures are also given. The optimization of the quantifier steps in proof search can be combined effectively with a number of other optimizations that are also based on permutability.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
ESD Investigations of Multiwalled Carbon Nanotubes (2014)

Electrostatic discharge (ESD) investigations on the multiwalled carbon nanotubes (MWCNTs) are performed for the first time. A novel ESD failure mechanism of subsequent shell burning has been discovered. By using nanosecond pulse measurements, a new insight into metal-to-carbon nanotube (CNT) contact behavior could be achieved. Clear signature of two very different conduction mechanisms and related failure types at high current injection has been found. By determining the time to failure, an Arrhenius-like relation was extracted, which was explained by the oxidation of CNT shells. Finally, an extraordinary ESD failure current density of MWCNT of 1.2 ×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">9</sup> A/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> could be shown.
Diagnostic and treatment implications of psychosis secondary to treatable metabolic disorders in adults: a systematic review (2014)

IEMs with a psychiatric presentation and a lack of, or sub-clinical, neurological signs are rare, but should be considered in patients with atypical psychiatric symptoms.
A new way to access the interaction forces between complex tissues and needles (2013)

The aim of this study is to determine a generic static loading basis applied on a medical needle inserted into human tissue during a percutaneous procedure. Such a basis can be worthwhile to highlight the forces effectively encountered in a medical act and may be useful to develop models of needle deflection or medium deformation.
Improving protein glycan coupling technology (PGCT) for glycoconjugate vaccine production (2020)

PCGT has the potential to overcome some of the limitations of chemical conjugation production methods. The technology has undergone significant development since its inception, and new discoveries are continually driving the field forward. Vaccines currently in clinical trials have demonstrated the potential of the PGCT to deliver effective glycoconjugate vaccines for unmet medical needs.
Conversion of 7-ketocholesterol to oxysterol metabolites by recombinant CYP27A1 and retinal pigment epithelial cells (2011)

Of the different oxygenated cholesterol metabolites, 7-ketocholesterol (7KCh) is considered a noxious oxy-sterol implicated in the development of certain pathologies, including those found in the eye. Here we elucidated whether sterol 27-hydroxylase cytochrome P450 27A1 (CYP27A1) is involved in elimination of 7KCh from the posterior part of the eye: the neural retina and underlying retinal pigment epithelium (RPE). We first established that the affinities of purified recombinant CYP27A1 for 7KCh and its endogenous substrate cholesterol are similar, yet 7KCh is metabolized at a 4-fold higher rate than cholesterol in the reconstituted system in vitro. Lipid extracts from bovine neural retina and RPE were then analyzed by isotope dilution GC-MS for the presence of the 7KCh-derived oxysterols. Two metabolites, 3β,27-dihydroxy-5-cholesten-7-one (7KCh-27OH) and 3β-hydroxy-5-cholesten-7-one-26-oic acid (7KCh-27COOH), were detected in the RPE but not in the neural retina. 7KCh-27OH was also formed when RPE homogenates were supplemented with NADPH and the mitochondrial redox system. Quantifications in human RPE showed that CYP27A1 is indeed expressed in the RPE at 2-4-fold higher levels than in the neural retina. The data obtained represent evidence for the role of CYP27A1 in retinal metabolism of 7KCh and suggest that, in addition to cholesterol removal, the functions of this enzyme could also include elimination of toxic endogenous compounds.
Fluoroscopically Guided Subacromial Spacer Implantation for Massive Rotator Cuff Tears: Two Years of Prospective Follow-up (2021)

The data suggest that fluoroscopically guided subacromial spacer implantation under local anesthesia is a low-risk, clinically effective option, especially for the elderly population and those patients who have multiple comorbidities or a contraindication to general anesthesia. Patients undergoing subacromial spacer implantation for the treatment of MRCTs had satisfactory outcomes at 2-year follow-up, with a low rate of complications.
Origin of efficient light emission from a phosphorescent polymer/organometallic guest-host system (2003)

Time-resolved photoinduced absorption measurements were performed at 77 K and room temperature on thin films of tris[9,9-dihexyl-2-(phenyl-${4}^{\ensuremath{'}}$-(-pyridin-${2}^{\ensuremath{''}}$-yl)fluorene]iridium(III) $[\mathrm{Ir}(\mathrm{DPPF}{)}_{3}]$ doped into a blend of poly$(N$-vinylcarbazole) (PVK) with 2-(4-biphenylyl)-5-(4-tert-butylphenyl)-1,3,4-oxadiazole (PBD). We observe that in the PVK-PBD host blend, charge trapping (CT) plays an important role in the excited-state dynamics, in addition to exciplex formation and intensity-dependent decay of primary excitations. We develop a physical model which includes all interactions and which is in excellent agreement with the data. We find that 35% of the initial photoexcitation channels into CT states and that exciplexes are formed at a rate of $1/10{\mathrm{ps}}^{\ensuremath{-}1}.$ For the $\mathrm{Ir}(\mathrm{DPPF}{)}_{3}$ doped host composite, we write the rate equations for all population densities (which include the above excited-state species) and include energy-transfer rates from the host to the guest molecules. In both 0.2% and 2% $\mathrm{Ir}(\mathrm{DPPF}{)}_{3}:(\mathrm{PVK}\ensuremath{-}\mathrm{PBD})$ blends, F\"orster energy-transfer rates drop to half their low-temperature values at room temperature. We attribute this difference to a limited availability of guest molecules ready for energy transfer following charge trapping and insufficient spectral overlap due to shifts in the highest occupied and lowest unoccupied molecular orbital levels of the guest upon hole trapping. We conclude that the overall host-guest energy transfer is almost complete at room temperature in the 2% phosphorescent blend, with a large contribution (35%) from CT states which exhibit emission at all probe wavelengths.
UHF fading in factories (1989)

The authors detail the results of narrowband propagation measurements performed at five factories. The extensive empirical data indicate that path loss is dependent upon local surroundings and is log-normally distributed, temporal fading is Rician, and small-scale signal fluctuations due to receiver motion are primarily Rayleigh, although Rician and log-normal distributions fit some of the data. Shadowing effects of common factory equipment likely to obstruct indoor radio paths are also examined.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Abstract 1187: The Champions TumorGraft Bank: A demographically-rich repository of preclinical TumorGraft models (2014)

Abstract Many oncology pharmaceuticals fail during phased clinical trials, having been advanced based on research using flawed preclinical models that do not accurately replicate human tumor biology. For example, numerous models are based on genetically-engineered mice, which are often generated from limited numbers of genetic aberrations. As such, they may not accurately represent either the chaotic heterogeneity that exists within intact human tumors or throughout the clinical population. TumorGrafts, in which patient-derived tumor tissue is directly engrafted into immunodeficient mice, offer a step forward in this unresolved issue. These models maintain the complex intra-tumoral heterogeneity and biology of an intact malignancy, as well its 3-dimensional interplay with stromal components and other cells fluxing into the immediate environment. The intrinsic cross-talk between the different compartments of the tumor is also retained. We wanted to generate a repository of these tumor models and make them available to the research community for use in pharmaceutical development and basic research processes. Here we describe our extensive bank of live TumorGrafts comprising a range of different tumor types, from more common cancers, including lung, colon, and breast, to a number of rare subtypes such as adenoid cystic carcinoma. These models were originally developed for personalizing cancer treatments and are derived from patient populations across all ages and ethnicities, encompassing both treatment-naïve and heavily-treated individuals. Furthermore, because of our distinct patient-focus, we maintain detailed clinical histories, as well as molecular data where available. Hence, the bank is a reasonable surrogate of the population from which treatment groups are typically drawn for clinical trials and could potentially be of value for predetermining target populations for therapeutic intervention. The Champions TumorGraft Bank provides superior pre-clinical models that faithfully capture all the biological and molecular features of cancer and can serve basic and clinical research groups as an increasingly valuable source for drug development and biomarker discovery. Citation Format: Tin Khor, David Vasquez, Amanda Katz, Gilson Baia, Daniel Ciznadija, David Sidransky, Keren Paz. The Champions TumorGraft Bank: A demographically-rich repository of preclinical TumorGraft models. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1187. doi:10.1158/1538-7445.AM2014-1187
Photochemically and Thermally Tunable Planar Defects in Colloidal Photonic Crystals (2005)

We report a bottom-up synthesis of a photochemically and thermally active azobenzene-based polyelectrolyte multilayer (PEM) planar defect embedded in a colloidal photonic crystal (CPC). Both photoisomerization and thermal cycling lead to a precise tuning of an intragap transmitting state induced by the PEM structural defect.
ChemInform Abstract: Synthesis and Properties of Oligodeoxynucleotides Incorporating a Conformationally Rigid Uridine Unit Having a Cyclic Structure at the 5′‐Terminal Site. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A new 3-D pattern recognition technique with application to computer aided colonoscopy (2005)

To utilize CT or MRI images for computer aided diagnosis applications, robust features that represent 3D image data need to be constructed and subsequently used by a classification method. We present a computer aided diagnosis system for early diagnosis of colon cancer. The system extracts features via a new 3D pattern processing method and processes them using a support vector machine classifier. Our 3D pattern processing method, called Random Orthogonal Shape Section (ROSS) mimics the radiologist's way of viewing these images and combines information from many random triples of mutually orthogonal sections going through the volume. Another contribution of the paper is a new feedback framework between the classification algorithm and the definition of the features. This framework, called Distinctive Component Analysis combines support vector samples with linear discriminant analysis to map the features of clustered support vectors to a lower dimensional space where the two classes of objects of interest are optimally separated to obtain better features. We show that the combination of these better features with support vector machine classification provides a good recognition rate.
Laser Diode Delivers Atomically-Resolved Images (1992)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Dror Sarid, Paul Pax, Virgil Elings, and Dan Bocek, "Laser Diode Delivers Atomically-Resolved Images," Optics & Photonics News 3(12), 35_1-36 (1992) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
CD4+ T‐cell responses and distribution at the colonic mucosa during Brachyspira hyodysenteriae‐induced colitis in pigs (2005)

The spirochaete Brachyspira hyodysenteriae causes swine dysentery, a severe colitis characterized by mucosal enlargement as a result of crypt elongation and epithelial necrosis. Most efforts to understand the pathogenesis of this disease have focused on the aetiological agent and its virulence factors. However, the host immune response has been considered an important factor in disease development. Previous research has shown that B. hyodysenteriae induces systemic CD4(+) and gammadelta T-cell responses after intramuscular immunization. Here, we have evaluated changes in the CD4(+) and gammadelta T-cell composition and distribution the different compartments of the colonic mucosa of pigs challenged with B. hyodysenteriae. We report that, in infected pigs, gammadelta T cells were significantly depleted from the epithelial layer, although their numbers were maintained in the lamina propria. In addition, CD4(+) T cells aggregated in clusters located in the lamina propria and submucosa. Ex vivo analyses of CD4(+) T-cell responses to B. hyodysenteriae antigens correlated with the changes in the mucosal CD4(+) T-cell distribution observed in infected pigs; CD4(+) T cells recovered from peripheral blood and colonic lymph nodes of infected pigs proliferated to B. hyodysenteriae antigens, whereas no differences were found in the gammadelta T-cell responses between challenged and control groups. In addition, colonic lymph node CD4(+) T cells had a predominant memory/activated phenotype. These results indicate that infection with B. hyodysenteriae induces a mucosal CD4(+) T-cell response and points to CD4(+) T cells being important contributors to the immunopathogenesis of swine dysentery.