gebhart/patrepeval huggingface dataset:
Insight into vergence/accommodation mismatch (2013)

Prolonged use of conventional stereo displays causes viewer discomfort and fatigue because of the vergence-accommodation conflict. We used a novel volumetric display to examine how viewing distance, the sign of the vergence-accommodation conflict, and the temporal properties of the conflict affect discomfort and fatigue. In the first experiment, we presented a fixed conflict at short, medium, and long viewing distances. We compared subjects' symptoms in that condition and one in which there was no conflict. We observed more discomfort and fatigue with a given vergence-accommodation conflict at the longer distances. The second experiment compared symptoms when the conflict had one sign compared to when it had the opposite sign at short, medium, and long distances. We observed greater symptoms with uncrossed disparities at long distances and with crossed disparities at short distances. The third experiment compared symptoms when the conflict changed rapidly as opposed to slowly. We observed more serious symptoms when the conflict changed rapidly. These findings help define comfortable viewing conditions for stereo displays.
Immunogenicity in dogs of three recombinant antigens (TSA, LeIF and LmSTI1) potential vaccine candidates for canine visceral leishmaniasis (2005)

Control of canine visceral leishmaniasis (VL) remains a difficult and serious problem mostly because there is no reliable and effective vaccine available to prevent this disease. A mixture of three recombinant leishmanial antigens (TSA, LeIF and LmSTI1) encoded by three genes highly conserved in the Leishmania genus have been shown to induce excellent protection against infection in both murine and simian models of cutaneous leishmaniasis. A human clinical trial with these antigens is currently underway. Because of the high degree of conservation, these antigens might be useful vaccine candidates for VL as well. In the present study, using the dog model of the visceral disease, we evaluated the immunogenicity of these three antigens formulated with two different adjuvants, MPL-SE and AdjuPrime. The results were compared with a whole parasite vaccine formulated with BCG as the adjuvant. In order to investigate if sensitization with the recombinant antigens would result in recognition of the corresponding native parasite antigens upon infection, the animals were exposed for four weeks after the termination of the immunization protocol with the recombinant antigens to a low number of L. chagasi promastigotes, an etiological agent of VL. Immune response was evaluated by quantitative ELISA in the animal sera before and after exposure to the viable parasites. Both antigen specific IgG1 and IgG2 antibody levels were measured. Immunization of dogs with the recombinant antigens formulated in either MPL-SE or AdjuPrime resulted in high antibody levels particularly to LmSTI1. In addition, this immunization although to low levels, resulted in the development of antibody response to the whole parasite lysate. Importantly, experimental exposure with low numbers of culture forms of L. chagasi promastigotes caused a clear boost in the immune response to both the recombinant antigens and the corresponding native molecules. The boost response was predominantly of the IgG2 isotype in animals primed with the recombinant antigens plus MPL-SE. In contrast, animals primed with the recombinant antigens formulated in AdjuPrime as well as animals vaccinated with crude antigen preparation responded with mixed IgG1/IgG2 isotypes. These results point to the possible use of this antigen cocktail formulated with the adjuvant MPL-SE in efficacy field trials against canine VL.
Dosimetry and efficacy of a tau PET tracer [18F]MK-6240 in Japanese healthy elderly and patients with Alzheimer’s disease (2022)

Japan Pharmaceutical Information Center ID, JapicCTI-194972.
Sensor planning and control in a dynamic environment (2003)

This paper presents an approach to the problem of controlling the configuration of a team of mobile agents equipped with cameras so as to optimize the quality of the estimates derived from their measurements. The issue of optimizing the robots' configuration is particularly important in the context of teams equipped with vision sensors since most estimation schemes of interest will involve some form of triangulation. We provide a theoretical framework for tackling the sensor planning problem and a practical computational strategy, inspired by work on particle filtering, for implementing the approach. We extend our previous work by showing how modeled system dynamics and configuration space obstacles can be handled. These ideas have been demonstrated both in simulation and on actual robotic platforms. The results indicate that the framework is able to solve fairly difficult sensor planning problems online without requiring excessive amounts of computational resources.
An α 1A ‐adrenoreceptor variant with differential response to agonists reveals a key site in the third intracellular loop for agonist‐specific regulation of receptor function (2007)

Agonist occupied α 1A ‐adrenorceptor (α 1A ‐AR) engages several signaling pathways including phosphoinositide hydrolysis, calcium mobilization, arachidonic acid release, MAP kinase activation and cAMP accumulation. The agonists A‐61603 and norepinephrine elicit maximal responses for calcium release and IP 3 accumulation in cell lines stably expressing the human α 1A ‐AR. Here we show that the actions of these two compounds differed in their activation of a variant of this receptor bearing a six amino acid insertion placed in the third intracellular loop (ICL3): A‐61603 was only a weak partial agonist while norepinephrine still displayed full agonist properties in a transient Ca +2 release assay. The EC 50 values for both compounds were comparable to those observed with wild‐type α 1A ‐AR. The differences in maximal response observed for these agonists at the ICL3 receptor variant may result from changes in agonist regulation of receptor coupling to the G‐protein complement. We hypothesize that the ICL3 mutation of α 1A ‐AR limits the accessible active state conformations in a manner that discriminates the agonist properties of norepinephrine and A‐61603. Signaling and binding profiles for A‐61603 and norepinephrine at the wild‐type and ICL‐3 variant α 1A ‐AR will be presented in support of this interpretation.
Anthranilate Fluorescence Marks a Calcium-Propagated Necrotic Wave That Promotes Organismal Death in C. elegans (2013)

For cells the passage from life to death can involve a regulated, programmed transition. In contrast to cell death, the mechanisms of systemic collapse underlying organismal death remain poorly understood. Here we present evidence of a cascade of cell death involving the calpain-cathepsin necrosis pathway that can drive organismal death in Caenorhabditis elegans. We report that organismal death is accompanied by a burst of intense blue fluorescence, generated within intestinal cells by the necrotic cell death pathway. Such death fluorescence marks an anterior to posterior wave of intestinal cell death that is accompanied by cytosolic acidosis. This wave is propagated via the innexin INX-16, likely by calcium influx. Notably, inhibition of systemic necrosis can delay stress-induced death. We also identify the source of the blue fluorescence, initially present in intestinal lysosome-related organelles (gut granules), as anthranilic acid glucosyl esters--not, as previously surmised, the damage product lipofuscin. Anthranilic acid is derived from tryptophan by action of the kynurenine pathway. These findings reveal a central mechanism of organismal death in C. elegans that is related to necrotic propagation in mammals--e.g., in excitotoxicity and ischemia-induced neurodegeneration. Endogenous anthranilate fluorescence renders visible the spatio-temporal dynamics of C. elegans organismal death.
THE FIRST INTRON OF HUMAN H-RAS IS REGULATED BY P53 - MEDIATION OF SPECIFIC ACTIVATION BY A P53-BINDING ELEMENT (1995)

We conducted transient reporter gene expression assays to show that the wild-type but not the mutant-type p53 protein positively regulates the expression of the human H-ras gene. This activation of expression is mediated through a specific p53-binding DNA element located in the first intron of the H-ras gene. This element is similar to a previously identified p53-binding element. Without this element, wild-type p53 represses the H-ras promoter, as do several p53 mutants. The repression function is lost when the N-terminal 81 amino acids of the p53 protein are deleted, suggesting that the N-terminus is required for repression. Therefore, p53 seems to regulate the H-ras through both positive and negative mechanisms.
Supplementary Figure S2 from Preclinical Development of the Anti-LAG-3 Antibody REGN3767: Characterization and Activity in Combination with the Anti-PD-1 Antibody Cemiplimab in Human <i>PD-1xLAG-3</i>–Knockin Mice (2023)

&lt;p&gt;Supplementary Figure S2 shows binding of REGN3767 to T cells&lt;/p&gt;
Sub-100 fs Fiber Feedback Synchronously Pumped Degenerate Optical Parametric Oscillator (2015)

We report on a synchronously pumped degenerate OPO operated at 250 MHz that generates 280 mW of transform-limited sub-100 fs pulses at 2.09 µm using a compact dispersion-compensated fiber feedback cavity.
Abstract 3431: Functional characterization of ARID2 in melanoma and melanocytes (2014)

Abstract In a recent exome sequencing study conducted by our laboratory, AT-rich interaction 2 (ARID2) was found to be mutated in 9% of melanoma samples. Of all the novel melanoma genes identified, ARID2 had the highest loss of function mutation burden—suggesting that ARID2 is likely inactivated in melanoma. Although it is well-established that ARID2 is a member of the ATP-dependent SWI/SNF chromatin remodeling complex, the mechanisms by which ARID2 functions as a tumor suppressor remain unclear, and its role in melanoma is completely unknown. The goal of this project is to characterize the role of ARID2 in melanoma genesis. Our preliminary data indicates that ARID2-mutant melanoma cells express low levels of both ARID2 and MITF—the master regulator of melanocyte differentiation and a lineage oncogene. On the other hand, other SWI/SNF components appear necessary for survival of an ARID2-mutant cell line. Ongoing efforts in the laboratory include soft agar assays and mouse xenografts to determine whether knockout of ARID2 via CRISPR technology can transform immortalized primary melanocytes. We are also investigating the larger SWI/SNF dependency of these mutant cell lines. By studying ARID2 inactivation in melanoma, we ultimately seek to pinpoint targetable vulnerabilities of ARID2-mutant cells from many cancer types. Citation Format: Flora Luo, Levi Garraway. Functional characterization of ARID2 in melanoma and melanocytes. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3431. doi:10.1158/1538-7445.AM2014-3431
Hydraulic brake system modeling and control for active control of vehicle dynamics (1999)

Active control of vehicle dynamics has become one of the top competitive features in today's automobiles. Vehicle dynamic control systems include antilock brakes, traction control and yaw control. The realization of these systems relies on the control of hydraulic brakes as well as other vehicle systems. Modeling of the hydraulic brake system is essential to the design of vehicle dynamic control systems. The paper describes the derivation of a hydraulic brake system model using the bond graph technique, and the design of a feedback control system with an adaptive gain schedule PD controller. In addition, simulation and experimental results are presented to illustrate the model validation and the controller performance.
Targets and targeted drugs in chronic myeloid leukemia (2008)

Chronic myeloid leukemia (CML) is probably the most extensively studied and best understood human leukemia. The disease has long served as and still is a paradigmatic model to test various preclinical and translational concepts in hematology, sometimes with overwhelming success as exemplified by the Philadelphia chromosome and BCR/ABL, stem cell transplantation, or the use of BCR/ABL tyrosine kinase inhibitors. More recent concepts aim at targeting leukemic stem cells and stem cell subclones in CML by novel drugs and drug-combinations, with the goal to improve drug therapy. Other concepts attempt to employ endogenous antibodies or negative growthregulators to block leukemic cell growth. Novel prognostic markers indicating minimal residual disease offer new opportunities to measure the clinical effects of such novel drugs on residual persistent CML stem cells in clinical practice. To discuss all these new developments and future concepts in CML, a Conference on ‘‘Targets and Targeted Drugs’’ was organized in Vienna in October 2007 (October 26‐28, 2007). The conference took place at the Renaissance Penta Hotel, located close to the city center. The participants, all well recognized authorities in the field, presented and discussed their most recent concepts and data in this conference. The current issue of ‘‘Leukemia and Lymphoma’’ is dedicated to this meeting and to the above mentioned concepts, and provides a series of minireviews prepared by participants of the conference. It is our hope that this publication-cluster will motivate basic science colleagues and clinical colleagues to make further efforts in CML research, with the ultimate goal being to develop new, better or even curative drug therapies in the future.
TOWARD DEVELOPMENT OF A NON-DESTRUCTIVE TECHNIQUE TO MEASURE THE AVAILABLE PRESTRESS IN PRESTRESSED CONCRETE GIRDERS. FINAL REPORT (1994)

The main objective of this study was to develop a nondestructive method to assess the available prestress in girders. The evaluated effective prestress can then be used to more accurately assess the load carrying capacity of the prestressed girder bridge. The results obtained from the application of this method can also help define more reasonable values for the prestress losses than those suggested by design codes. In this study, a previous method for estimating the available prestress is reviewed and its shortcomings are identified. Further, a new method is introduced and its theoretical concept is explained. The applicability of the new method has been examined by testing concrete blocks under a known state of axial stress. In order to resolve several questions that arose during development of this new method, numerous 2-D and 3-D finite element analyses of the test specimens were conducted. Further, the applicability of the method is examined by conducting tests on a prototype prestressed girder to predict the available effective prestress. The predicted prestress is compared to that obtained from crack testing of the girder. Although the method promises a very efficient means for evaluation of available prestress in prestressed girders, refinements and improvements are still needed. Future studies needed to improve the new method are highlighted.
Abstract 2936: JNJ-47117096, a selective small molecule inhibitor of the MELK oncogene decreases DNA damage tolerance in highly proliferating cancer cells (2014)

Abstract Maternal embryonic leucine zipper kinase (MELK, hMP38, pEG3), a Ser/Thr protein kinase, is highly overexpressed in stem cells and cancer cells. The oncogenic role of MELK is attributed to disabling critical cell cycle check points as well as enhancing replication. Most functional studies have relied on the use of siRNA/shRNA mediated gene silencing, but this often can be associated with off-target effects. Here we want to present a novel, potent and selective small molecule inhibitor JNJ-47117096 that has enabled us to validate the biological function of MELK kinase. Outcome: MELK inhibition in cancer cells with an intact p53 signaling pathway is linked to a replicative senescence phenotype. This phenotype correlates with a rapid ATM activation and phosphorylation of CHK2 without any effects on the alternative ATR/ CHK1 DNA damage pathways. Furthermore, JNJ-47117096 induces strong phosphorylation of p53 and prolonged up-regulation of p21 without the induction of apoptosis. Strikingly, MELK inhibition in several p53 disabled cancer cells showed induction of a mitotic catastrophe phenotype followed by prominent cell killing. Finally, JNJ-47117096 triggers a rapid degradation of cellular MELK protein, independent of the cell cycle phase and its regulation by the E2F pathway. This observation can clearly be linked to a direct binding effect of JNJ-47117096 to cellular MELK protein confirmed by chemical proteomics. Conclusion: Our data generated with JNJ-47117096, confirmed by selective siRNAs, indicate MELK as a key stimulator of proliferation and replication by its ability to increase the threshold for DNA damage tolerance. Targeting MELK function by selective small molecule inhibitors might sensitise tumors to DNA-damaging agents or radiation therapy. Citation Format: Lijs Beke, Joannes T.m. Linders, Cenk Kig, An Boeckx, Erika van Heerde, Dirk Wuyts, Marc Parade, Lieven Meerpoel, Chris Johnson, Monique Beullens, Mathieu Bollen, Dirk Brehmer. JNJ-47117096, a selective small molecule inhibitor of the MELK oncogene decreases DNA damage tolerance in highly proliferating cancer cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2936. doi:10.1158/1538-7445.AM2014-2936
Wireless access burst scheduling discipline supporting integrated services in wireless ATM networks (2002)

In this paper, we propose a layered access control protocol, which incorporates a dynamic polling scheme on a burst level into the fair cell scheduling (polling-based wireless access burst scheduling: P-WABS) algorithms. Both the real-time and non-real-time multimedia services can be efficiently supported under the framework of the layered access control in the wireless ATM networks. Since it provides a contention-free access control mechanism, it turns out to be adequate for the multimedia services with the real-time constraints. Multimedia service traffic, including the constant bit rate (CBR), real-time variable bit rate (rt-VBR) and available bit rate (ABR) services, is considered to analyze the proposed scheme. Simulation results show that the proposed approach significantly improves the cell loss performance of rt-VBR services while a reasonable level of fairness is achieved for the ABR services.
The efficacy and environmental implications of engineered TiO2 nanoparticles in a commercial floor coating (2017)

Engineered nanomaterials (ENM) have diverse applications in consumer products, but few studies weigh the improved product performance resulting from the inclusion of an ENM against the unintended consequences of released ENM.
Effective recycling of manganese oxide cathodes for lithium based batteries (2016)

A facile cathode recycling process is demonstrated where the previously used binder-free self-supporting cathodes (BFSSC) are removed from a cell, heat treated, and then inserted into a new cell restoring the delivered capacity and cycle life.
Role of CMOS Back-End Metals as Active Electrodes for Resistive Switching in ReRAM Cells (2016)

With the goal to render the ReRAM memory integrable with CMOS backend and compatible with current BEOL metal choices (Cu, Ta, Ti, W), we have chosen the well-behaved and well-characterized Cu/TaOx/Pt ReRAM cell as a benchmark device and have replaced the active (Cu) and inert (Pt) electrodes with Ta and Ti electrodes. Five derivative devices were manufactured including: Pt/TaOx/Pt, Cu/TaOx/Ti, Cu/TaOx/Ta, Ta/TaOx/Pt, and Ti/TaOx/Pt. Out of these five devices, only the Ti/TaOx/Pt produced reliable set and reset switching characteristics. Nevertheless, the switching behavior of the other derivative devices provides a great deal of insight into the formation, shape and rupture of conductive filaments in ReRAM devices which would be difficult to gain otherwise from only one type of a device. The present findings are compared with results on the same and similar devices reported elsewhere in the literature.
ChemInform Abstract: Synthesis of (Alkenyl(dimethylamino)carbene)tungsten Complexes Using the Peterson Reaction: X‐Ray Crystal Structure of (E)‐(CO)5W(C(NMe2)CH=CH(η‐C5H4)Fe(η‐C5H5)). (1989)

Abstract Treatment of (III) with BuLi yields a lithium salt which reacts with several nonenolizable aldehydes or ketones to yield the desired title complexes such as (V), exclusive formation of the E isomer occurs.
Peptic ulcer disease (2020)

Abstract Helicobacter pylori infection, use of nonsteroidal anti-inflammatory drugs (NSAIDs) including aspirin, and smoking are the most important causes of peptic ulcer disease. Peptic ulcer disease is characterized by a history of waxing and waning symptoms of localized, dull, aching pain in the upper abdomen. Bleeding is the most common complication; free perforation of the stomach or duodenum into the peritoneal cavity is uncommon but serious. The diagnosis of peptic ulcer disease is made by endoscopy, which offers an opportunity for biopsy of gastric ulcers (which may be malignant) and reveals important prognostic indicators in patients with bleeding ulcers. A single daily dose of a proton pump inhibitor gives quick relief of symptoms and effective healing of peptic ulcers in 4 to 6 weeks. The management of patients with upper gastrointestinal haemorrhage requires a multidisciplinary medical and surgical approach. Early risk stratification based on clinical and endoscopic criteria allows delivery of appropriate care, with endoscopic intervention now widely accepted as the first line of therapy. This should be followed by administration of a high dose of an intravenous proton pump inhibitor to further reduce recurrent bleeding. Treatment of H. pylori is a cure for peptic ulcer disease in most patients. This usually requires at least two antimicrobial agents, with the most popular triple therapy combining a proton pump inhibitor with any two of amoxicillin, metronidazole, and clarithromycin for 7 to 14 days. Eradication of H. pylori infection, avoidance of high-dose NSAIDs or aspirin, and the maintenance use of proton pump inhibitors in high-risk individuals are the best ways to prevent recurrence of ulcer and ulcer complications.
Flower Voice: Virtual Assistant for Open Data (2013)

Open Data is now collecting attention for innovative service creation, mainly in the area of government, bioscience, and smart X project. However, to promote its application more for consumer services, a search engine for Open Data to know what kind of data are there would be of help. This paper presents a voice assistant which uses Open Data as its knowledge source. It is featured by improvement of accuracy according to the user feedbacks, and acquisition of unregistered data by the user participation. We also show an application to support for a field-work and confirm its effectiveness.