gebhart/patrepeval huggingface dataset:
Interaction Between Retinol Intake and ISX rs5755368 Polymorphism in Colorectal Cancer Risk: A Case-control Study Among the Korean Population (2021)

Abstract There is limited evidence about the interaction between retinol intake and the intestine-specific homeobox (ISX) rs5755368 polymorphism in colorectal cancer (CRC) risk. We conducted a hospital-based case-control study to examine whether the ISX rs5755368 genotypes are associated with the effect of dietary retinol consumption on CRC risk. First, to identify the association between dietary retinol and CRC risk, we recruited 923 CRC patients and 1846 controls. Dietary retinol intake was assessed using a semiquantitative food frequency questionnaire. For genetic analysis, genotype data were available for 1419 patients (600 cases and 819 controls) out of the total study population. ISX rs5755368 genotyping was performed using an Illumina MEGA-Expanded Array. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using unconditional logistic regression models. Retinol intake was inversely associated with the development of CRC (OR = 0.49; 95% CI = 0.37–0.63) after adjusting for confounders. Patients with homozygous AA genotype of the ISX rs5755368 polymorphism were less likely to have CRC risk than subjects carrying the G allele (AG+GG) (OR = 0.76; 95% CI = 0.58–0.99). Additionally, a 68% reduced risk of CRC was related to the highest retinol intake among those carrying the rs5755368 AA genotype compared to the risk of participants carrying the G allele consumed the lowest retinol intake (OR = 0.32; 95% CI = 0.20–0.53; P interaction=0.026). In conclusion, our study confirmed a protective role of retinol intake in CRC risk reduction. Moreover, this association was strengthened significantly among individuals carrying the homozygous AA genotype of the ISX rs5755368 polymorphism.
A Study of Clustering Algorithms for Time-Varying Multipath Components in Wireless Channels (2021)

Extensive channel measurements have shown that multipath components (MPCs) generally exist as clusters, and cluster-based channel models are therefore widely used for system design and assessment. Since the dynamic behavior, i.e., the time evolution, of the channels plays an important role for many applications, an accurate algorithm for the clustering of time-varying MPCs is required; a variety of algorithms have been proposed, yet little attention has been given to a fair comparison of their relative advantages and drawbacks. In this paper, we review and investigate the typical clustering methods for MPCs in wireless channels. Three popular classes of algorithms, namely distance-based (K-Power-Means), density-based (K-power-density), and evolution-based clustering methods, are analyzed and compared based on both synthetic and measured channel data. The F-measure is used to quantify and evaluate the clustering performance of the three algorithms, and also investigate their performance when only static snapshots of the channel are available. From the comparison, the evolution-based clustering method shows great potential to address the dynamic clustering problem for wireless time-varying channels.
Abstract 3641: The predictive and prognostic roles of DNA damage response genes in epithelial ovarian cancer (2012)

Abstract Background: Despite platinum-based chemotherapy, 5-year survival of advanced stage ovarian cancer patients is only 15-30%. Exposure to platinum-based chemotherapeutics induces double strand DNA breaks (DSBs) and subsequently leads to activation of the DNA damage response (DDR). Therefore inhibition of components of the DDR may lead to better response to therapy. Aim of this study was to investigate in a large series of ovarian cancer patients the predictive and prognostic role of the activation status of four DDR-proteins- ATM, a key controller in the DDR, and three ATM substrates, including Chk2, 53BP1 and γ-H2AX, of which the latter is a direct readout for DNA damage. Methods: Expression of phospho-ATM, Chk2, phospho-Chk2, 53BP1, phospho-53BP1 and γ-H2AX was immunohistochemically assessed in 309 patients with chemo-naive ovarian cancer. Expression levels were related to clinicopathological characteristics and survival. Response to platinum-based chemotherapy was analyzed by defining two populations with either an optimal therapy response or a very poor therapy response. Both groups consisted of patients with advanced stage ovarian cancer, &amp;gt;2 cm residual disease after primary surgery and were all treated with platinum-based chemotherapy. The responder group had a well-defined PFS of more than 18 months while the non-responder group had a PFS of less than 6 months. Results: In the two well-defined groups with the largest contrast regarding response to treatment, positive γ-H2AX expression (OR=0.193; p=0.036) and positive Chk2 expression (OR=0.149; p=0.011) were related to a good response to platinum-based chemotherapy. In advanced stage patients, phospho-53BP1 expression was independently related to a worse disease-specific survival (HR=1.905; p= 0.044). Conclusion: High DDR protein expression in advanced stage ovarian cancers suggests a high degree of genomic instability, while the negative prognostic impact of phospho-53BP1 may be due to enhanced repair capacity of chemotherapy-induced DSBs on the long term. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3641. doi:1538-7445.AM2012-3641
Failure and fatigue characteristics of adhesive athletic tape (2002)

In understanding the shortcomings of currently available tapes, the results of these tests can now be used as benchmarks with which to compare and develop future tape designs. Ultimately, these improved tapes should reduce ankle injuries among athletes.
High Spatial Density Few-mode Multi-core Fiber for Dense Space Division Multiplexing Transmission (2016)

We review recent progress on multi-core fiber with few-mode cores and introduce our highest spatial density 6-mode multi-core fiber with a low differential mode delay, a low crosstalk and a feasible cladding diameter.
Magnetic resonance cholangiopancreatography (MRCP): a perspective on potential clinical applications. (1998)

The recent development of MRCP allowed the recognition of the potential role of Magnetic Resonance (MR) in pancreatobiliary imaging. The increasing interest on MRCP relies on its non invasiveness (there is no need for contrast media administration) and on the projectional display of the biliary and pancreatic ducts in a way similar to endoscopic retrograde cholangiopancreatography (ERCP) or percutaneous transhepatic cholangiography (PTC). In addition, it offers the opportunity for dynamic analysis of biliopancreatic ducts which is useful in the assessment of subtle ductal alterations. The future of this attractive technique will depend on the demonstration of its diagnostic accuracy and on its availability. This article discusses the potential role of MRCP in the evaluation of biliary tract and pancreatic duct diseases.
Replication of polyethylene nano-micro hierarchical structures using ultrasonic forming (2010)

We present the replication of polyethylene (PE) nano-micro hierarchical structures and their application for superhydrophobic surfaces. A commercial ultrasonic welding system was used to apply ultrasonic vibration energy to the forming of nano-micro hierarchical structures. To evaluate ultrasonic formability, Ni nanomold and nano-micro hierarchical mold were designed and fabricated. The optimal weld times were 1.5 s and 3.0 s for PE nanoprotrusions and nano-micro hierarchical structures, respectively. The forming process was conducted at atmospheric pressure. The PE structures were well replicated without a vacuum. The trapped air in the microcavity of the nano-micromold was dispersed and absorbed into the molten PE. Ultrasonic nano-microreplication technology showed an extremely short processing time and did not require a vacuum environment. To investigate the applicability of ultrasonic forming, the fabricated nanoprotrusions and nano-micro hierarchical structures were coated with plasma polymerized fluorocarbon (PPFC) of a hydrophobic nature and were applied to modify superhydrophobic surfaces. The contact angle was increased from 106° (smooth surface) to 125° (nanostructured surface) and finally to 160° (nano-microstructured surface) so that the surface became superhydrophobic.
The role of carbon paper as current collector-substrate in tin-based anodes for lithium-ion batteries (2005)

The strategies of the intermetallic compounds and of morphological conversion toward nanomaterials to buffer the volume changes during the lithiation/delithiation processes in lithium-metal alloys, although beneficial, have been not conclusive to overcome this drawback.&#13;\nTo improve the cyclability performance of nanometric lithium-metal alloys we regarded the electrode materials as a whole with the current collector and we focused our efforts on the carbon paper (CP) as an alternative substrate-current collector to the conventional copper. The CP, with its three-dimensional interconnected conductive fibers, was able to host the metals and intermetallic materials and to guarantee a good electric contact without addition of carbon as conducting agent, providing a significantly improved cycling stability of these electrodes as shown in Figure 1.&#13;\nTo get an insight into the effective role of CP on the cycling stability of lithium-metal alloy/CP electrodes we compared the electrochemical and structural behavior over repeated lithiation/delithiation cycles of different types of tin-based materials on CP such as Sn, Cu6Sn5 and Sn2Mn and the results of this study are presented and discussed in this contribution.
Mechanistic studies of carbonate macrocyclization (1994)

Abstract The kinetics of phenylchloroformate (PCF) reactions have been used to model some of the key chemical events in carbonate macrocyclization. Three reactions have been studied using stopped‐flow FT‐IR spectroscopy: formation of acyl ammonium salt from PCF and three different trialkylamines, the conversion of acyl ammonium salt to urethane, and the condensation reaction between acyl ammonium salt and 4‐isopropylphenol. The rate dependence was studied for triethylamine (TEA), diethylmethylamine (DEMA) and tri‐ n ‐butylamine (TBA) at 0°C in anhydrous CH 2 Cl 2 . The reactivity order for acyl ammonium salt formation for TBA: TEA: DEMA is 1 : 2.7 : &gt;444. By contrast, condensation and urethane formation are not sensitive to the structure of the amine. The rate of condensation is comparable to the rate of acyl ammonium salt formation for TEA and TBA, while the rate of urethane formation is the slowest process for all three amines. These results are consistent with the view that the yield of macrocyclic polycarbonates is related to the concentration of the acyl ammonium salt. The optimum amine concentration for obtaining high yields of cyclics varies with the amine structure and parallels the difference in the rates of acyl ammonium salt formation. © 1994 John &amp; Sons, Inc.
HLA class II-Restricted CD8+ T cells in HIV-1 Virus Controllers (2019)

A paradigm shifting study demonstrated that induction of MHC class E and II-restricted CD8+ T cells was associated with the clearance of SIV infection in rhesus macaques. Another recent study highlighted the presence of HIV-1-specific class II-restricted CD8+ T cells in HIV-1 patients who naturally control infection (virus controllers; VCs). However, questions regarding class II-restricted CD8+ T cells ontogeny, distribution across different HIV-1 disease states and their role in viral control remain unclear. In this study, we investigated the distribution and anti-viral properties of HLA-DRB1*0701 and DQB1*0501 class II-restricted CD8+ T cells in different HIV-1 patient cohorts; and whether class II-restricted CD8+ T cells represent a unique T cell subset. We show that memory class II-restricted CD8+ T cell responses were more often detectable in VCs than in chronically infected patients, but not in healthy seronegative donors. We also demonstrate that VC CD8+ T cells inhibit virus replication in both a class I- and class II-dependent manner, and that in two VC patients the class II-restricted CD8+ T cells with an anti-viral gene signature expressed both CD4+ and CD8+ T cell lineage-specific genes. These data demonstrated that anti-viral memory class II-restricted CD8+ T cells with hybrid CD4+ and CD8+ features are present during natural HIV-1 infection.
A New ID-based Signature with Batch Verification. (2004)

In 1984, Shamir proposed a new public key cryptography, the identity (ID)-based encryption and signature schemes which allows any pair of users to communicate securely and to verify each other’s signatures without exchanging certificates. Since then, we have several ID-based signatures based on the discrete logarithm problem. While they have an advantage that the system secret can be shared by several parties through threshold schemes, they have a critical disadvantage in efficiency. To enhance the efficiency of verification, we propose a new ID-based signature scheme that allows batch verification of multiple signatures. The verification cost of the proposed signature scheme for k signatures is almost constant with minimal security loss and when a new signature by a different signer is added to the batch verification, the additional cost is almost a half of that of a single signature. We prove that the proposed signature scheme is secure against existential forgery under adaptively chosen message and ID attack in the random oracle model and show why other ID-based signature schemes are hard to achieve these properties.
Formation Process of Y2O3:Bi3+,Eu3 + Nanosheets from Hydroxide Precursor Nanosheets (2021)

We studied the formation of Y 2 O 3 :Bi 3+ ,Eu 3+ nanosheets from different Y 2 O 3 precursors to propose a mechanism for their formation. One limitation of solar cells is their low sensitivity to near-ultraviolet light, which may be improved by including a phosphor to convert near-ultraviolet light to visible light, which can be readily absorbed. An attractive phosphor for this role is Y 2 O 3 :Bi 3+ ,Eu 3+ ; however, it remains unclear how Y 2 O 3 :Bi 3+ ,Eu 3+ forms from Y 2 O 3 precursor nanosheets. Therefore, we studied the formation of Y 2 O 3 :Bi 3+ ,Eu 3+ nanosheets from Y 2 O 3 precursors fabricated under various conditions including different pH, base type, and autoclave duration. We found that single-crystalline Y 2 O 3 :Bi 3+ ,Eu 3+ nanosheets formed from Y 2 O 3 precursor nanosheets produced under suitable conditions. The Y 2 O 3 :Bi 3+ ,Eu 3+ nanosheets retained the crystallographic orientation of the precursor Y 2 O 3 nanosheets. The formation of these nanosheets did not require the presence of organic ligands. Our findings indicate that Y 2 O 3 :Bi 3+ ,Eu 3+ nanosheet formation involved anisotropic assembly of crystallized nanoparticles and a subsequent dissolution–recrystallization process. The Y 2 O 3 :Bi 3+ ,Eu 3+ nanosheets fabricated under certain conditions displayed absorption and emission properties suitable for use as solar converters.
Ribosomally Synthesized Thiopeptide Antibiotics Targeting Elongation Factor Tu (2009)

We identified the thiomuracins, a novel family of thiopeptides produced by a rare-actinomycete bacterium typed as a Nonomuraea species, via a screen for inhibition of growth of the bacterial pathogen Staphylococcus aureus. Thiopeptides are a class of macrocyclic, highly modified peptides that are decorated by thiazoles and defined by a central six-membered heterocyclic ring system. Mining the genomes of thiopeptide-producing strains revealed the elusive biosynthetic route for this class of antibiotics. The thiopeptides are chromosomally encoded, ribosomally synthesized proteins, and isolation of gene clusters for production of thiomuracin and the related thiopeptide GE2270A revealed the post-translational machinery required for maturation. The target of the thiomuracins was identified as bacterial Elongation Factor Tu (EF-Tu). In addition to potently inhibiting a target that is unexploited by marketed human therapeutics, the thiomuracins have a low propensity for selecting for antibiotic resistance and confer no measurable cross-resistance to antibiotics in clinical use.
l-Carnosine, a Substrate of Carnosinase-1, Influences Glucose Metabolism (2007)

hCN1-dependent susceptibility to diabetic nephropathy may at least in part be mediated by altered glucose metabolism in type 2 diabetic patients.
Omeprazole Prevents Colistin-Induced Nephrotoxicity in Rats: Emphasis on Oxidative Stress, Inflammation, Apoptosis and Colistin Accumulation in Kidneys (2022)

The clinical value of colistin, a polymyxin antibiotic, is limited by its nephrotoxicity. Omeprazole is a commonly prescribed proton pump inhibitor. The current study aimed to evaluate the effects of the concomitant administration of omeprazole on colistin-induced nephrotoxicity in rats. Omeprazole significantly ameliorated colistin nephrotoxicity as evidenced by prevention in the rise in the serum level of creatinine, urea and cystactin C as well as urinary N-acetylglucosamine activity. This was confirmed by histological studies that indicated a decreased incidence of interstitial nephritis, degenerative cortical changes and collagen deposition. This was accompanied by the prevention of oxidative stress as omeprazole significantly inhibited the lipid peroxidation, glutathione depletion and enzymatic exhaustion of superoxide dismutase as well as catalase. Additionally, omeprazole inhibited the expression of interleukin-6 and tumor necrosis factor-α. Further, omeprazole inhibited the colistin-induced rise in Bax and the down-regulation of Bcl2 mRNA expression. An assessment of the serum levels of colistin revealed that omeprazole had no significant impact. However, it was observed that omeprazole significantly inhibited the accumulation of colistin in kidney tissues. In conclusion, omeprazole protects against colistin-induced nephrotoxicity. This can be attributed to, at least partly, omeprazole's anti-oxidant, anti-inflammatory and anti-apoptotic activities in addition to its ability to prevent the toxic accumulation of colistin in kidneys.
Air Pressure for Blast Lamps (1933)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAir Pressure for Blast LampsG THiessen and J WertzCite this: Ind. Eng. Chem. Anal. Ed. 1933, 5, 3, 201Publication Date (Print):May 1, 1933Publication History Published online11 July 2002Published inissue 1 May 1933https://doi.org/10.1021/ac50083a600RIGHTS & PERMISSIONSArticle Views21Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (179 KB) Get e-Alerts
Mice with Induced Pulmonary Comorbidities Display Severe Lung Inflammation and Mortality following Exposure to SARS-CoV-2 (2020)

Abstract Severe manifestations of COVID-19 are mostly restricted to people with comorbidities. Here we report that induced mild pulmonary morbidities render SARS-CoV-2-refractive CD-1 mice to be susceptible to this virus. Specifically, SARS-CoV-2 infection after application of low-doses of the acute-lung-injury stimulants bleomycin or ricin caused a severe disease in CD-1 mice, manifested by sustained body weight loss and mortality rates of &gt;50%. Further studies revealed markedly higher levels of viral RNA in the lungs, heart and serum of low-dose-ricin pretreated, as compared to non-pretreated mice. Notably, the deleterious effects of SARS-CoV-2 infection were effectively alleviated by passive transfer of polyclonal or monoclonal antibodies generated against SARS-CoV-2 RBD. Thus, viral cell entry in the sensitized mice seems to involve viral RBD binding, albeit by a mechanism other than the canonical ACE2-mediated uptake route. In summary, we present a novel mice-based animal model for the study of comorbidity-dependent severe COVID-19.
Isolation and genomic characterization of a Dehalococcoides strain suggests genomic rearrangement during culture (2017)

We have developed and characterized a bacterial consortium that reductively dechlorinates trichloroethene to ethene. Quantitative PCR analysis for the 16S rRNA and reductive dehalogenase genes showed that the consortium is highly enriched with Dehalococcoides spp. that have two vinyl chloride reductive dehalogenase genes, bvcA and vcrA, and a trichloroethene reductive dehalogenase gene, tceA. The metagenome analysis of the consortium by the next generation sequencer SOLiD 3 Plus suggests that a Dehalococcoides sp. that is highly homologous to D. mccartyi 195 and equipped with vcrA and tceA exists in the consortium. We isolated this Dehalococcoides sp. and designated it as D. mccartyi UCH-ATV1. As the growth of D. mccartyi UCH-ATV1 is too slow under isolated conditions, we constructed a consortium by mixing D. mccartyi UCH-ATV1 with several other bacteria and performed metagenomic sequencing using the single molecule DNA sequencer PacBio RS II. We successfully determined the complete genome sequence of D. mccartyi UCH-ATV1. The strain is equipped with vcrA and tceA, but lacks bvcA. Comparison with tag sequences of SOLiD 3 Plus from the original consortium shows a few differences between the sequences. This suggests that a genome rearrangement of Dehalococcoides sp. occurred during culture.
Stationary distributions of systems with Discreteness Induced Transitions (2020)

We provide a theoretical analysis of some autocatalytic reaction networks exhibiting the phenomenon of discretely induced transitions (DITs). The family of networks that we address includes the celebrated Togashi and Kaneko model. We prove positive recurrence, finiteness of all moments, and geometric ergodicity of the models in the family. For some parameter values, we find the analytic expression for the stationary distribution, and discuss the effect of volume scaling on the stationary behavior of the chain. We find the exact critical value of the volume for which DITs disappear.
NMR Studies of the Hydrogen Storage Compound NaMgH3 (2009)

Hydrogen and 23Na NMR were performed to 400 °C on NaMgH3 powder produced by reactive ball-milling of NaH and MgH2. The H resonance shows narrowing already at 100 °C as a narrow line superimposed on the broad, rigid-lattice signal. With increasing temperature, the fraction of spins in the narrow component grows smoothly, approaching 100% near 275 °C. This heterogeneous narrowing suggests a wide distribution of H motion rates. After annealing at 400 °C, the narrow component intensity at temperatures below 200 °C was substantially reduced and both H and 23Na relaxation rates 1/T1 were decreased. Thus, it appears that the high rates of H motion, particularly on first heating, are due to regions with poorly organized crystal structure. If this disorder could be maintained, this might be an avenue toward improved reaction kinetics of this or other hydrides. In the annealed sample, the activation energy for H diffusion is approximately 95 kJ/mol.