gebhart/patrepeval huggingface dataset:
Low Complexity Channel Model for Mobility Investigations in 5G Networks (2020)

Millimeter-wave has become an integral part of 5G networks to meet the ever-increasing demand for user data throughput. Employing higher carrier frequencies introduces new challenges for the propagation channel such as higher path loss and rapid signal degradations. On the other hand, higher frequencies allow deployment of small-sized antenna elements that enable beamforming. To investigate user mobility under these new propagation conditions, a proper model is needed that captures spatial and temporal characteristics of the channel in beamformed networks. Current channel models that have been developed for 5G networks are computationally inefficient and lead to infeasible simulation time for most user mobility simulations. In this paper, we present a simplified channel model that captures the spatial and temporal characteristics of the 5G propagation channel and runs in feasible simulation time. To this end, coherence time and path diversity originating from fully fledged Geometry based Stochastic Channel Model (GSCM) are analyzed and adopted in Jake's channel model. Furthermore, the deviation of multipath beamforming gain from single ray beamforming gain is analyzed and a regression curve is obtained to be used in the system-level simulations. We show through simulations that the proposed simplified channel model leads to mobility results comparable to Jake's model for high path diversity. Moreover, the multi-path beamforming gain increases the interference in the system and in turn number of mobility failures.
Present state and possibilities for improvement of cancer prevention and early detection in the Osijek-Baranya county. (2005)

Cancer morbidity and mortality are on a steady increase in Croatia. Technologic possibilities for appropriate management are available for four cancer sites, i.e. cancer of the breast, cervix uteri, colorectum and prostate, and include cancer prevention and early detection in individuals yet free from manifest signs of the disease. The magnitude of the problem, the experience acquired to date, health care personnel available, and additional resources required to launch a systematic program of early detection of the disease are presented. The program should be initially launched in a county with greatest experience in early detection of cancer, where health care service is ready to immediately start its implementation. The role of family physician, gynecologic service at primary health care level, and polyclinic-consultation hospital service in program implementation is described. The following three possible options for early detection of cancer are analyzed and proposed: minimal program (early detection every 3 years), medium program (the same individuals examined every 2 years), and optimal program proposed by the American Cancer Society and other national and international organizations.
COMPLIANCE TESTING OF IOWA’S SKID-MOUNTED SIGN DEVICE (1999)

A wide variety of traffic control devices are used in work zones, some of which are nont ormally found on the roadside or in the traveled way outsideofthe work zones. These devices are used to enhance the safety of the work zones by controlling the traffic through these areas. Due to the placement of the traffic control devices, the devices themselves may be potentially hazardous to both workers and errant vehicles. The impact performance of many work zone traffic control devices is mainly unknown and to date limited crash testing has been conducted under the criteria of National Cooperative Highway Research Program (NCHRP) Report No. 350, Recommended Procedures for the Safety Performance Evaluation of Highway Features. The objective of the study was to evaluatethe safety performance of existing skid-mounted sign supports through full- scale crash testing. Two full-scale crash tests were conducted on skid-mounted sign supports to determine their safety performance according to the Test Level 3 (TL-3) criteria set forth in the NCHRP Report No. 350. The safety performancevaluations indicate that these skid-mounted sign supports did not perform satisfactorily in the full-scale crash tests. The results of the crash tests were documented, and conclusions and recommendations pertaining tothe safety performance of the existing work zone traffic control devices were made.
Insulin Binding to Erythrocytes Incubatedin Vitroat Physiological Temperature (1983)

We have investigated the previously described time-dependent increase in specific insulin binding to freshly isolated human erythrocytes incubated at 37 C. We found that at 37 C, specific insulin binding to erythrocytes rose to and remained at equilibrium for the first 90 min of incubation; thereafter, it rose in a rapid linear fashion, directly related to the increase in the degradation of unbound insulin and paralleling the intensity of visible hemolysis. The rise in specific binding was intensified by conditions in which hemolysis was enhanced and attenuated by conditions designed to limit hemolysis or by agents capable of inhibiting the degradation of insulin despite hemolysis. Thus, gentle handling of the cells prevents hemolysis, the degradation of insulin, and the increase in apparent insulin binding. Furthermore, 5% albumin, 2.5 mM N-ethylmaleimide, or excess unlabeled insulin (100 micrograms/ml) inhibited insulin degradation (even in the presence of hemolysis) and prevented the rise in insulin binding. The rise in cell-associated radioactivity after 90 min of incubation at 37 C was due to cellular uptake of products of insulin degradation, since degraded [125I]insulin rapidly associated with freshly prepared erythrocytes. Acid extraction studies suggested that about 60% of the cell-associated degraded material was intracellular, while the remaining approximately 40% was bound to the cell surface. The data suggest that the rise in binding in erythrocytes incubated at 37 C is a result of insulin degradation products which associate with the cells. The generation of degraded insulin is due to hemolysate released from leaky cells, and this phenomenon is unique to the in vitro situation.
Effect of Fv-1 gene product on proviral DNA formation and integration in cells infected with murine leukemia viruses. (1976)

The amounts of unintegrated murine leukemia virus-specific DNA detected by molecular hybridization in extracts of Fv-ln/n (strains NIH/3T3, SIM) or Fv-lb/b (strains JLS-V9, SIM.R) mouse cells after infection with N- or B-tropic viruses were found to be the same in both permissive and resistant cells. Therefore, formation of DNA products from the viral RNA template does not appear to be grossly affected by the Fv-l gene product. Integration of virus-specific DNA into chromosomal cellular DNA was assayed by hybridization of radioactive complementary DNA to DNA from infected cells. With either NIH/3T3 or SIM.R cells infected with N- or B-tropic viruses, integration of proviral DNA could be detected in permissive cells but not in nonpermissive cells. The Fv-l gene product therefore appears to prevent integration of proviral DNA.
PERFORMANCE EVALUATION OF POROUS RADIANT GAS BURNERS (1995)

A porous radiant burner testing facility was built, consisting of temperature and gas composition measurements as a function of position, as well as spectral and total radiosity measurements, Vncombusted hydrocarbons were detected within the flame support layer for only low flow rates (e.g., 7.1 L / min for a reticulated ceramic flame support layer); only combustion products mixed with the atmosphere were detected at higher rates. Radiosity increased with increasing flow rait via increasing surface temperatures, while burner efficiencies decreased because of less effectual heat transfer of combustion product gases to solid surfaces. Stainless steel screen-based flame support layers demonstrated optimum performance as compared to ceramic and metal tube-based and reticulated ceramic-based flame support layers. Increased turbulent ylow and surface area for connective heat transfer between the base surface and the end of the flame support layer were factors attributed to improved burner radiosity and efficiency. The graybody temperatures and emittances of burners were determined using a simplex algorithm fit of spectral radiosity data to Planck's equation. The significantly higher and more gray emittance (hence radiosity) ofCoAl2O4-coated muliite flame support tubes, as compared to alumina tubes of identical geometry, was demonstrated using this method.
Plague The mysterious past and terrifying future of the world’s most deadly disease (2005)

Original citation: J. Clin. Invest. 115:4(2005).

Citation for this erratum: J. Clin. Invest. 115:476 (2005).

The title of the book reviewed was incorrectly given. The correct book title is Plague: the mysterious past and terrifying future of the world's most dangerous disease.
Identification of prostate cancer modifier pathways using parental strain expression mapping (2007)

Inherited genetic risk factors play an important role in cancer. However, other than the Mendelian fashion cancer susceptibility genes found in familial cancer syndromes, little is known about risk modifiers that control individual susceptibility. Here we developed a strategy, parental strain expression mapping, that utilizes the homogeneity of inbred mice and genome-wide mRNA expression analyses to directly identify candidate germ-line modifier genes and pathways underlying phenotypic differences among murine strains exposed to transgenic activation of AKT1. We identified multiple candidate modifier pathways and, specifically, the glycolysis pathway as a candidate negative modulator of AKT1-induced proliferation. In keeping with the findings in the murine models, in multiple human prostate expression data set, we found that enrichment of glycolysis pathways in normal tissues was associated with decreased rates of cancer recurrence after prostatectomy. Together, these data suggest that parental strain expression mapping can directly identify germ-line modifier pathways of relevance to human disease.
Amino acid repeats avert mRNA folding through conservative substitutions and synonymous codons, regardless of codon bias (2017)

A significant number of proteins in all living species contains amino acid repeats (AARs) of various lengths and compositions, many of which play important roles in protein structure and function. Here, I have surveyed select homopolymeric single [(A)n] and double [(AB)n] AARs in the human proteome. A close examination of their codon pattern and analysis of RNA structure propensity led to the following set of empirical rules: (1) One class of amino acid repeats (Class I) uses a mixture of synonymous codons, some of which approximate the codon bias ratio in the overall human proteome; (2) The second class (Class II) disregards the codon bias ratio, and appears to have originated by simple repetition of the same codon (or just a few codons); and finally, (3) In all AARs (including Class I, Class II, and the in-betweens), the codons are chosen in a manner that precludes the formation of RNA secondary structure. It appears that the AAR genes have evolved by orchestrating a balance between codon usage and mRNA secondary structure. The insights gained here should provide a better understanding of AAR evolution and may assist in designing synthetic genes.
Color Polymer-Stabilized Liquid Crystal for the Optical Shutter with Fast Response Time (2011)

A color-reflective optical shutter structure has been studied using polymer-stabilized liquid crystal (PSLC) devices with a specular reflector. The combined effect of an LC, a polymer, a color dye, and a specular reflector results in a high performance of a reflective-mode optical shutter as well as of a simple structure with a fast response time capable of smooth moving images. The reflectance is up to 40%, one of highest for reflective devices, whose response times are fast enough to provide video speed response (<16.6 ms). This effective and simple shutter concept can be applied in reflective-mode flexible displays and optical equipment with high performance.
Use of Latanoprostene Bunod as Adjunctive Glaucoma Therapy in Refractory Glaucoma (2023)

Zhou B, Bekerman VP, Khouri AS. Use of Latanoprostene Bunod as Adjunctive Glaucoma Therapy in Refractory Glaucoma. J Curr Glaucoma Pract 2022;16(3):166-169.
<title>Color management system with multilayer perceptrons</title> (1999)

This paper has two objectives. The first is to explain our color reproduction procedure, especially our new gamut check and mapping method and comparative experimental results on it. The second is to discuss availability and effectiveness of multilayer perceptron (MLP) in the color reproduction fields. We will show problems and merits of MLP and its learning through experiments.
J-Springs - innovative compliant interconnects for next-generation packaging (2003)

The advances made in the design and the fabrication of integrated circuits (ICs) have far outpaced the advances made in the design and the fabrication of chip-to-substrate interconnects as well as high-density substrates. According to the International Technology Roadmap for Semiconductors (ITRS) for 2014, the chip-to-substrate interconnects should have a pitch of about 40 /spl mu/m and should be able to accommodate the coefficient of thermal expansion (CTE) mismatch of low-cost organic substrates without resorting to expensive reliability solutions. In this paper, a novel chip-to-substrate interconnect - J-Spring - is proposed and fabricated. J-Spring is a compliant interconnect fabricated through stress-engineered metal layers, and the fabrication is based on traditional IC fabrication process. The J-Springs have excellent compliance in the three orthogonal directions, and the interconnect is designed to accommodate the high differential displacement due to CTE mismatch between silicon ICs and organic substrates under various thermal conditions.
NB-IoT deployment study for low power wide area cellular IoT (2016)

In 3GPP, a narrowband system based on Long Term Evolution (LTE) has been introduced to support the Internet of Things. This system, named Narrowband Internet of Things (NB-IoT), provides low-cost devices, high coverage (20 dB improvement over LTE/GPRS), long device battery life (more than 10 years), and massive capacity. Latency is relaxed although a delay budget of 10 seconds is the target for exception reports. NB-IoT can be deployed in three different operation modes - (1) stand-alone as a dedicated carrier, (2) in-band within the occupied bandwidth of a wideband LTE carrier, and (3) within the guard-band of an existing LTE carrier. In this paper, we undertake a deployment study of NB-IoT using existing LTE infrastructure. We consider the case when only a fraction of the existing LTE cell sites support NB-IoT (so called partial deployment of NB-IoT). In this case, NB-IoT devices cannot attach to the best cell if that cell does not support NB-IoT. As a result, the path loss can be very high. In addition, they also suffer from high interference from non-NB-IoT cells. We examine potential techniques to compensate for the high path-loss and high interference and provide analysis to indicate when partial deployment of NB-IoT is feasible. We also examine interference issues in asynchronous deployments and study performance.
CD73 Promotes Resistance to HER2/ErbB2 Antibody Therapy (2017)

Expression of the ectonucleotidase CD73 by tumor cells, stromal cells, and immune cells is associated in cancer with immune suppression. In this study, we investigated the role of CD73 on the activity of the anti-HER2/ErbB2 monoclonal antibody (mAb) trastuzumab. In a prospective, randomized phase III clinical trial evaluating the activity of trastuzumab, high levels of CD73 gene expression were associated significantly with poor clinical outcome. In contrast, high levels of PD-1 and PD-L1 were associated with improved clinical outcome. In immunocompetent mouse models of HER2/ErbB2-driven breast cancer, CD73 expression by tumor cells and host cells significantly suppressed immune-mediated responses mediated by anti-ErbB2 mAb. Furthermore, anti-CD73 mAb therapy enhanced the activity of anti-ErbB2 mAb to treat engrafted or spontaneous tumors as well as lung metastases. Gene ontology enrichment analysis from gene-expression data revealed a positive association of CD73 expression with extracellular matrix organization, TGFβ genes, epithelial-to-mesenchymal transition (EMT) transcription factors and hypoxia-inducible-factor (HIF)-1 gene signature. Human mammary cells treated with TGFβ or undergoing EMT upregulated CD73 cell-surface expression, confirming roles for these pathways. In conclusion, our findings establish CD73 in mediating resistance to trastuzumab and provide new insights into how CD73 is regulated in breast cancer. <i>Cancer Res; 77(20); 5652-63. ©2017 AACR</i>.
Synthesis, single crystal X-ray diffraction, Hirshfeld surface and biological activity of quinolone derivatives (2017)

Two new quinolone derivatives, 5-nitroquinolin-8-yl-3-bromobenzoate (1) and 5-nitroquinolin-8-yl-3-chlorobenzoate (2), were synthesized and their structures were elucidated using X-ray diffraction techniques. Both compounds crystallized in P 2 1 / n (monoclinic) space group having four independent molecules in asymmetric unit. The dihedral angle between benzene and planner quinoline rings in compounds 1 and 2 were found to be 117.7(2) and 117.4(2)ᵒ, respectively. No intermolecular hydrogen bonding was observed in compound 1. However, C-H···O intermolecular interaction was found to connect the molecules in crystal lattice of compound 2. Hirshfeld surfaces analysis was performed to evaluate the directions, and strength of interactions of molecules of compounds and 1 and 2 with neighbouring molecules, and the major contribution in the crystal packing was due to O-H (1, 24.6% and 2, 25.1%) interactions. The synthesized quinoline derivatives were found as potent anti-bacterial agents against E. coli reference (ATCC25922 and ATCC 35218) and multi-drug resistant strains (M2 and M3) with 91.42 to 94.72% inhibition. Both compounds 1 and 2 showed weak antileishmanial activity against L. Major promastigotes in vitro with IC 50 values 73.2±3.1 and 72.2±2.3 mg/mL, respectively, and also found as cytotoxic in nature against 3T3 fibroblast cell line.
Synthesis of albumin microbubbles using a microfluidic device for real-time imaging and therapeutics (2013)

A method for producing monodisperse albumin stabilized microbubbles (MBs) using a flow-focusing microfluidic device (FFMD) is introduced. This method allows for localized delivery of short life-time microbubbles with a biocompatible shell, thereby potentially improving patient safety. In this study, microbubbles stabilized with bovine serum albumin (BSA) are characterized for microbubble coalescence, size, and production rate using a high speed camera. Microbubbles were produced with diameters between 10-20 μm and production rates up to 6×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sup> MB/s were achieved. Microbubble diameter was observed to decrease linearly (R <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> > 0.99) with liquid flow rate. Microbubble stability was evaluated acoustically using a clinical ultrasound scanner. The image intensity of a well-mixed solution containing 13 μm microbubbles returned to baseline from peak intensity within 30s. Delivery of the membrane impermeable fluorophore calcein was demonstrated using microbubbles produced in situ within an in vitro flow chamber. 11 μm diameter microbubbles insonated at a peak negative pressure (PNP) of 200 kPA resulted in 58.0% of cells to uptake calcein. To demonstrate the ability to stabilize microbubbles directly with blood, plasma was separated from whole bovine blood, input into the FFMD, and used to produce microubbbles. These plasma microbubbles were imaged under flow in a gelatin flow phantom and demonstrated a 6.5 dB increase in lumen contrast.
Quantitative immunoassay for soya protein in raw and sterilized meat products (1986)

An enzyme‐linked immunosorbent assay (ELISA) is described for the quantitative analysis of soya protein in meat products. The assay is applicable to raw and sterilized products and is not dependent on soya variety and type of soya ingredient (concentrate, isolate, etc.). Therefore, the assay can be applied without knowledge of product composition, heat pretreatment and other processing conditions. The ELISA is specific for soya; no interference of other product components has been found. The detection limit of the ELISA is 0.5% soya protein. Qualitative analysis by immunoblotting is possible at much lower concentrations. The antibodies used are specific for sodium dodecyl sulphate (SDS) denatured soya protein subunits. The products are extracted with SDS and 2‐mercaptoethanol, which guarantees optimum recovery of the protein components. Product extracts can be analysed directly by ELISA without removal of the SDS by using nitrocellulose as a solid phase.
Development of new calcium receptors based on oxazolidin-2-ones containing pseudopeptides (2005)

With the aim of designing a new calcium receptor, the synthesis and the conformational analysis of a small library of dipeptides having the general formula Ac-Oxx-L-Xaa-OBn [Oxx = L-Oxd, (4S,5R)-4-methyl-5-carboxyoxazolidin-2-one; D-Oxd, (4R,5S)-4-methyl-5-carboxyoxazolidin-2-one; or D-Oxac (4R)-(2-oxo-1,3-oxazolidin-4-yl)-acetic acid] is reported. Ac-L-Oxd-L-Ala-OBn was identified as the most promising compound by MS-ESI analysis and this outcome was confirmed by photoluminescence spectroscopy.
Detection, parametric imaging and classification of very small marine targets emerged in heavy sea clutter utilizing GPS-based Forward Scattering Radar (2014)

In this paper, we address a technique and related algorithms for precise detection, parametric imaging and classification of small marine targets in a harsh sensing environment attributed for heavy sea clutter via noncooperative processing of the GPS-based Forward Scatter Radar (FSR) data. In contrary to GPS L5 detection approach, the proposed technique utilizes civil GPS L1 signal formats in FSR exploiting GPS as a non-cooperative transmitter. In our previous studies it is shown that the use of the new power GPS signal L5, and the Forward Scattering effect providing a high SNR, at the detector input allows reliably to detect small air targets in conditions of the intense interference. In this paper we propose another approach, to enhance SNR, at the input of the detector in Forward Scattering Radar (FSR). The use of the effective filter (Local Variance Filter) for suppression of intensive sea clutter allows FSR reliably to detect small marine targets emerged in harsh sea clutter, but with GPS L1 signal, whose SNR is very small. At the classification level, the data mining approach is adopted, in which the target feature parameters are extracted from the preliminary filtered signals by utilizing the modified structure of a processor for target detection and parameter estimation in the time domain. Both, the decision tree-based and the neural network classifiers are featured and adapted for real-time implementation. The efficiency of the proposed technique is verified via analytical performance evaluations and experimental demonstrations.