gebhart/patrepeval huggingface dataset:
Crossing the barrier of service innovation in hotel industry: An integrating process view (2013)

Even though innovations are desirable, the customers and organization may resist them. This paper explores how the firm crosses the barrier of service innovation and discusses the organizational management issue. This study uses hotel industry as empirical setting and takes the service-oriented approach. From the case study, it finds out that the radical and incremental innovation is integrated. While radical innovation can be viewed as market driving idea which comes from the leader's vision of market opportunity, the incremental innovation from the service team is a sufficient material. The integrating process is supported by the entrepreneurial management which includes both control system and inducement system. Control system is a well-developed innovation process. However, considering service is a combination of processes, people skills, and materials, the inducement system of service entrepreneurship is important. It makes the firm overstep the service standard operation procedure (SOP) and pursue sustainability.
The effect of very high hydraulic pressure on the permeability and salt rejection of reverse osmosis membranes (2015)

We employ a stirred-cell reverse osmosis setup to demonstrate that a seawater reverse osmosis membrane can maintain excellent salt rejection at pressures as high as 172 bar. However, we also demonstrate a very significant drop in membrane permeability at high pressures–likely due to membrane compaction. At 172 bar, permeability is more than 50% lower than at a pressure of 34.5 bar. In addition, our results illustrate how flux fluctuates significantly in time when the pressure is removed and then reapplied, even for very short periods, in high pressure reverse osmosis processes–an effect that requires careful consideration from the perspective of process control and operation. From the perspective of membrane performance, RO is feasible at high pressures but distinct challenges are presented by reduced permeability and increased variability in flux.
31P−15N Coupling Constants and 15N/14N Isotope Effects on 31P NMR Chemical Shifts of 2-Phenylamino-2-oxo(-thioxo, -selenoxo)- 4-methyl-1,3,2-dioxaphosphorinanes and Related Compounds (1983)

The strong influence of a chalcogen atom (O, S, Se) attached to phosphorus on the spin-spin coupling constant 1 J(P- 15 N) in the family of diastereoisomeric 2-| 15 N] -phenyl-amino-2X(X = O, S, Se)-4-methyl-l,3,2-dioxaphosphorinanes is demonstrated. The 15 N/ 14 N isotope effect on the nuclear shielding of phosphorus-31 is larger for the shorter equatorial than for the longer axial P-N bonds.
AT 1 Receptor Antagonist Combats Oxidative Stress in the JGA of the SHR (2000)

24 The tubuloglomerular feedback (TGF) responses of the SHR are under exaggerated regulation by angiotensin II (Ang II) type 1 receptors (AT 1 -R). Since AT 1 -R enhance oxygen radical (O 2 - ) generation, we tested the hypothesis that the exaggerated TGF was due to a diminished blunting by macula densa (MD)-derived nitric oxide (NO) because of excessive AT 1 -R-dependent generation of O 2 - . Groups (n=6-9) of SHR and control WKY rats received vehicle (Veh), the AT 1 -R antagonist candesartan (Cand; 3 mg·kg -1 ·d -1 ) or non-specific therapy with hydralazine + hydrochlorothiazide + reserpine (HHR) for two weeks. Compared to WKY, the elevated mean arterial pressure of SHR (WKY: 125±2 vs. SHR: 163±9 mmHg; p&lt;0.001) was reduced (p&lt;0.001) similarly in SHR by Cand and HHR (121±5 and 116±5 mmHg, ns). The SHR had an increased maximal TGF response (change in stop flow pressure during luminal perfusion of fluid: SHR; 11.2±0.5 vs. WKY; 8.3±0.4 mmHg; p&lt;0.01) and a reduced TGF response to blockade of neuronal (n) NOS in the MD with luminal 7-nitroindazole (7-NI: ΔTGF in WKY: +2.8±0.4 vs. SHR +1.1±0.6 mmHg; p&lt;0.05). Although the elevated TGF responses of SHR were normalized by both HHR and Cand, only Cand restored a normal TGF response to luminal perfusion of the MD with 7-NI (ΔTGF with 7-NI: +1.8±0.4 vs. Cand +3.4±0.5 mmHg; p&lt;0.05). To abrogate the local effects of O 2 - , tempol (a membrane-permeable superoxide dismutase mimetic) was perfused into the efferent arteriole. During tempol, SHR given vehicle or HHR had a much increased response to blockade of nNOS with 7-NI (ΔTGF with 7-NI during tempol: Veh, +6.3±1.0 and HHR, +4.5±0.8 mmHg; p&lt;0.01 vs. no tempol for both) implying that the effects of NO had been prevented because of excessive O 2 - . In contrast, the TGF response to 7-NI in SHR given Cand was unaffected by tempol (ΔTGF with 7-NI during tempol: +2.9±0.9; ns compared to no tempol). In conclusion, TGF responses of SHR are exaggerated due to effects of hypertension and AT 1 -R. AT 1 -R blockade specifically diminishes oxidative stress and restores NO signaling in the JGA of the SHR.
Insulin Signals to Prenyltransferases via the Shc Branch of Intracellular Signaling (2001)

We assessed the roles of insulin receptor substrate-1 (IRS-1) and Shc in insulin action on farnesyltransferase (FTase) and geranylgeranyltransferase I (GGTase I) using Chinese hamster ovary (CHO) cells that overexpress wild-type human insulin receptors (CHO-hIR-WT) or mutant insulin receptors lacking the NPEY domain (CHO-DeltaNPEY) or 3T3-L1 fibroblasts transfected with adenoviruses that express the PTB or SAIN domain of IRS-1 and Shc, the pleckstrin homology (PH) domain of IRS-1, or the Src homology 2 (SH2) domain of Shc. Insulin promoted phosphorylation of the alpha-subunit of FTase and GGTase I in CHO-hIR-WT cells, but was without effect in CHO-DeltaNPEY cells. Insulin increased FTase and GGTase I activities and the amounts of prenylated Ras and RhoA proteins in CHO-hIR-WT (but not CHO-DeltaNPEY) cells. Overexpression of the PTB or SAIN domain of IRS-1 (which blocked both IRS-1 and Shc signaling) prevented insulin-stimulated phosphorylation of the FTase and GGTase I alpha-subunit activation of FTase and GGTase I and subsequent increases in prenylated Ras and RhoA proteins. In contrast, overexpression of the IRS-1 PH domain, which impairs IRS-1 (but not Shc) signaling, did not alter insulin action on the prenyltransferases, but completely inhibited the insulin effect on the phosphorylation of IRS-1 and on the activation of phosphatidylinositol 3-kinase and Akt. Finally, overexpression of the Shc SH2 domain completely blocked the insulin effect on FTase and GGTase I activities without interfering with insulin signaling to MAPK. These data suggest that insulin signaling from its receptor to the prenyltransferases FTase and GGTase I is mediated by the Shc pathway, but not the IRS-1/phosphatidylinositol 3-kinase pathway. Shc-mediated insulin signaling to MAPK may be necessary (but not sufficient) for activation of prenyltransferase activity. An additional pathway involving the Shc SH2 domain may be necessary to mediate the insulin effect on FTase and GGTase I.
VEGF-D: a modifier of embryonic lymphangiogenesis (2008)

In this issue of Blood, Ny and colleagues disclose a modifier role for VEGF-D and a critical function for VEGFR-3 in embryonic lymphangiogenesis in Xenopus tadpoles.
Amniotic Fluid Angiopoietin-1, Angiopoietin-2, and Soluble Receptor Tunica Interna Endothelial Cell Kinase-2 Levels and Regulation in Normal Pregnancy and Intraamniotic Inflammation-Induced Preterm Birth (2010)

Ang-1, Ang-2, and sTie2 are physiological constituents of AF that are GA and IAI regulated. Ang-2/Ang-1 ratio may play a role in modulating the fetal inflammatory response to IAI. Placental sTie2 shedding likely involves a Golgi-mediated mechanism.
Poly(vinylsaccharide)s, 5. Synthesis and characterization of poly(vinylsaccharide)s of the amide type with disaccharides in the side chain (1989)

Abstract The synthesis of well‐defined monovinylsaccharide monomers containing disaccharide units is described. Four different monomers, N ‐disaccharide‐substituted acryl‐ and methacrylamides, were prepared and polymerized to the corresponding polymers by free‐radical polymerization in aqueous solution using different initiator systems. The influence of the structural differences of the disaccharide units on the solution properties was studied by viscosity and light scattering measurements. A comparison with known poly(vinylsaccharide)s with monosaccharides in the side chain is made.
Lupus antibodies induce behavioral changes mediated by microglia and blocked by ACE inhibitors (2018)

Cognitive impairment occurs in 40-90% of patients with systemic lupus erythematosus (SLE), which is characterized by autoantibodies to nuclear antigens, especially DNA. We discovered that a subset of anti-DNA antibodies, termed DNRAbs, cross reacts with the N-methyl-d-aspartate receptor (NMDAR) and enhances NMDAR signaling. In patients, DNRAb presence associates with spatial memory impairment. In a mouse model, DNRAb-mediated brain pathology proceeds through an acute phase of excitotoxic neuron loss, followed by persistent alteration in neuronal integrity and spatial memory impairment. The latter pathology becomes evident only after DNRAbs are no longer detectable in the brain. Here we investigate the mechanism of long-term neuronal dysfunction mediated by transient exposure to antibody. We show that activated microglia and C1q are critical mediators of neuronal damage. We further show that centrally acting inhibitors of angiotensin-converting enzyme (ACE) can prevent microglial activation and preserve neuronal function and cognitive performance. Thus, ACE inhibition represents a strong candidate for clinical trials aimed at mitigating cognitive dysfunction.
A solid-state dye-sensitized solar cell based on a novel ionic liquid gel and ZnO nanoparticles on a flexible polymer substrate (2008)

This paper describes a new strategy to make a full solid-state, flexible, dye-sensitized solar cell (DSSC) based on novel ionic liquid gel, organic dye, ZnO nanoparticles and carbon nanotube (CNT) thin film stamped onto a polyethylene terephthalate (PET) substrate. The CNTs serve both as the charge collector and as scaffolds for the growth of ZnO nanoparticles, where the black dye molecules are anchored. It opens up the possibility of developing a continuous roll to roll processing for THE mass production of DSSCs.
Increased Osteoprotegerin Predicts Poor Virological Outcome During Anticytomegalovirus Therapy in Solid Organ Transplant Recipients (2014)

Our finding indicates that elevated osteoprotegerin levels in solid organ transplant recipients with CMV infection may reflect vascular inflammation and is associated with late virological outcome in these patients.
Analysis of Effective Molecular Diffusion Rates for Verteporfin in Subcutaneous Versus Orthotopic Dunning Prostate Tumors¶ (2004)

Photosensitizer biodistribution change inside tissue is one of the dominant factors in photodynamic therapy efficacy. In this study, the pharmacokinetics of a benzoporphyrin derivative (BPD), delivered in verteporfin for injection formulation, have been quantified in the rat Dunning prostate tumor MAT-LyLu model, using both subcutaneous and orthotopic sites. Blood plasma sampling indicated that BPD had a bi-exponential metabolic lifetime in vivo, with the two lifetimes being 9.6 min and 8.3 h. The spatial distributions in the tumor were quantified as a function of distance from the perfused blood vessels, using fluorescence histologic images of the tumor. A fluorescent vascular marker was used to obtain locations and shapes of perfused capillaries at a wavelength of emission different from that of BPD and to allow colocalized images to be acquired of vessel and BPD locations. Using the BPD fluorescence images obtained 15 min after intravenous administration, a forward finite-element solution to the diffusion equation was used to predict the drug distribution by matching the fluorescence intensity images observed microscopically. An inverse solver was used to minimize the root mean square error between the image of simulated diffusion and the experimental image, resulting in estimation of the diffusion coefficient of BPD in the tumor models. Effective diffusion coefficients were 0.88 and 1.59 microm2/s for the subcutaneous and orthotopically grown tumors, respectively, indicating that orthotopic tumors have significantly higher vascular extravasation rates as compared with subcutaneous tumors. This analysis supports the hypothesis that leakage rates of the photosensitizer vary considerably. Thus, although varying the time between injection and optical irradiation may be used to vary the targeting between vascular and less vascular areas, the precise time of treatment will depend on the nature of the permeability of the vasculature in the tissue being treated.
Synthesis and reactions of optically pure cyclohexyl(o‐methoxyphenyl)phosphine‐borane and t‐butyl‐(o‐methoxyphenyl)phosphine‐borane (1993)

Abstract Cyclohexyl(o‐methoxyphenyl)menthyloxyphosphineborane and t‐butyl(o‐methoxyphenyl)menthyloxyphosphine‐borane were prepared from dichlorocyclohexylphosphine and t‐butyldichlorophosphine by successive treatments with (−)‐menthol, o‐methoxyphenylmagnesium bromide, and borane‐THF complex. The separated pure diastereomers of each of the compounds underwent reaction with lithium naphthalenide to afford optically pure cyclohexyl(o‐methoxyphenyl)phosphine‐borane and t‐butyl(o‐methoxyphenyl)phosphine‐borane, respectively. These secondary phosphine‐boranes reacted readily with various electrophiles in the presence of bases with virtually net retention of configuration. A new chiral phosphine ligand, (S,S)‐1,2‐bis[cyclohexyl(o‐methoxyphenyl)phosphino]ethane was synthesized via the optically pure phosphine‐boranes.
The DSS LOGDIS Optimizes Delivery Routes for FRILAC’s Frozen Products (2005)

We designed a decision-support system for FRILAC Company in Navarre, Spain, to optimize its routes for delivering frozen products. FRILAC’s logistics department had been organizing deliveries based on vehicle runs, but FRILAC deemed this process inaccurate and expensive. We suggested simplifying this procedure by creating a decision-support system (DSS). We had a twofold aim: to design a route builder geared specifically to the road network of the area and to integrate the DSS into the global management of the company. We achieved both objectives by constructing the DSS LOGDIS in Microsoft Access. LOGDIS, using Clarke and Wright’s (1964) algorithm, designs routes that minimize distances traveled, shows final outcomes on screen, creates reports for vehicle drivers, and estimates route costs. FRILAC has successfully implemented the results, reaching an average cost saving of 10 percent.
Increasing participation of women in the engineering curriculum (2002)

Undergraduate and graduate programs in engineering should strive to attract the best talent and resources to the discipline. These programs should provide students with a firm foundation in the relevant fundamentals and prepare students for effective positions in industry and academia. It is important that the fundamental theories be correlated with practical examples from industry, e.g. automotive, aerospace, and software industries, to demonstrate the applications of the theories and to excite the students to investigate other practical possibilities on their own. There are many challenging and fulfilling career options available in the engineering discipline after graduation. What are some of the barriers that are preventing women from participating fully in the engineering discipline and how can we overcome them? There are 3 phases where the situation of women participation in the engineering curriculum needs to be assessed: (1) pre-engineering education phase-recruitment; (2) engineering education phase-retention; and (3) post-engineering education phase-placement and advancement.
Simulation of Mini-Magnetospheric Plasma Propulsion (M2P2) Interacting with an External Plasma Wind (2003)

Substantial progress has been made over the last year in the development of the laboratory Mini-Magnetospheric Plasma Propulsion (M2P2) prototype. The laboratory testing has shown that that the plasma can be produced at high neutral gas efficiency, at high temperatures (a few tens of eV) with excellent confinement up to the point where chamber wall interactions dominate the physics. This paper investigates the performance of the prototype as it is opposed by an external plasma acting as a surrogate for the solar wind. The experiments were performed in 5ft diameter by 6ft long vacuum chamber at the University of Washington. The solar wind source comprised of a 33 kWe arc jet attached to a 200 kWe inductively generated plasma source. The dual plasma sources allow the interaction to be studied for different power levels, shot duration and production method. It is shown that plasma from the solar wind source (SWS) is able to penetrate the field of the M2P2 magnetic when no plasma is present. With operation of the M2P2 plasma source at only 1.5 kWe, the penetration of the SWS even at the highest power of operation at 200 kWe is stopped. This deflection is shown to be greatly enhanced over that produced by the magnet alone. In addition it is shown that with the presence of the SWS, M2P2 is able to produce enhanced magnetized plasma production out to at least 10 magnet radii where the field strength is only marginally greater than the terrestrial field. The results are consistent with the initial predictions that kWe M2P2 systems would be able to deflect several hundred kWe plasma winds to produce enhanced propulsion for a spacecraft.
SAW immunosensors for HBsAb detection (2008)

This paper presents the implementation of a surface acoustic wave (SAW) immunosensor system for real sample detection of antibody to hepatitis B surface antigen (HBsAg). The SAW sensor device was based on the mass detection using LOVE wave with the central frequency of 200 MHz. The thickness of the SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> guiding layer was optimized both theoretically and experimentally to obtain the maximum sensitivity. A detection circuitry using a differential scheme measured the frequency difference by subtracting the resonant frequency of the sample SAW from that of the reference SAW. The sensitivity of the sensor was 0.74 Hz/(pg/mulscr) and the detection limit was 10 pg/mulscr. Our SAW sensor successfully detected natural anti-HBsAg antidbody (HBsAb) of the real whole blood samples, which opens up a possibility of label-free protein detection without any pretreatment procedures.
Linear operation of high-power millimeter-wave stacked-FET PAs in CMOS SOI (2012)

Stacked-FET PAs have emerged as a promising circuit technique for high-power CMOS PAs at millimeter-wave bands. Common-source (1-stack) and 3-stack PAs are realized in 45-nm CMOS SOI and compared at 45-GHz. The saturated output power increases from 10 dBm to more than 18 dBm respectively for 1- and 3-stack PAs. Compression and EVM/ACP measurements for QAM modulation are presented to discuss the linearization requirements of millimeter-wave stacked-FET PAs.
QC-DOC: Web-Based Centralized Application for Authentication of the Quality Assurance System (2011)

Quality assurance (QA) is the process used to help ensure products and services are fit for purpose and right the first time. A newly introduced QA system for a major service company follows a structured and well defined process to help ensure quality and vendor compliance. This process is managed using a centralized web-based authentication system (WAS) called QC-Doc QC-Doc is a real-time role-based system designed to manage product life-cycle including product history, vendor and lot management, testing procedures and results data. This system has automated and streamlined the previously used Quality Management System (QMS) and quality workflows. Consequently, the number of non-compliant vendors has dramatically decreased resulting in less intervention and fewer corrective measures. Additionally, the system provides shelflife management leading to less product spoilage. The system provides global access to product status within the various QA workflows. Users can view product history, test procedures, QA lab results, vendor test results, and lot shelf-life. Vendors can view their test results history relative to product lots as well. Using the global product database additional statistical analysis of vendor and product performance metrics can easily be obtained. A dashboard component allows real-time monitoring of the holistic QA process.
Effects of intrinsic spin on electronic transport through magnetic barriers (1996)

It is shown that the interaction of the intrinsic spin of two-dimensional electrons with the magnetic field significantly changes the tunneling probability of electrons through magnetic barriers and the conductance of devices having such barriers with respect to the case where this interaction is neglected. It is also shown that certain structures having these magnetic barriers possess the ability to distinguish the two possible spin states of the electrons. \textcopyright{} 1996 The American Physical Society.
Impact of Hard Mask Composition and Etching Chemistry on Porous Ultra Low-k Material Modification (2005)

International audience
Molecular imaging of fibrosis: recent advances and future directions (2019)

Fibrosis, the progressive accumulation of connective tissue that occurs in response to injury, causes irreparable organ damage and may result in organ failure. The few available antifibrotic treatments modify the rate of fibrosis progression, but there are no available treatments to reverse established fibrosis. Thus, more effective therapies are urgently needed. Molecular imaging is a promising biomedical methodology that enables noninvasive visualization of cellular and subcellular processes. It provides a unique means to monitor and quantify dysregulated molecular fibrotic pathways in a noninvasive manner. Molecular imaging could be used for early detection, disease staging, and prognostication, as well as for assessing disease activity and treatment response. As fibrotic diseases are often molecularly heterogeneous, molecular imaging of a specific pathway could be used for patient stratification and cohort enrichment with the goal of improving clinical trial design and feasibility and increasing the ability to detect a definitive outcome for new therapies. Here we review currently available molecular imaging probes for detecting fibrosis and fibrogenesis, the active formation of new fibrous tissue, and their application to models of fibrosis across organ systems and fibrotic processes. We provide our opinion as to the potential roles of molecular imaging in human fibrotic diseases.
Trimming of silicon nitride microring resonators with a polysilane top cladding (2005)

We demonstrate 23.5 nm shifts of Si/sub 3/N/sub 4/ microring resonances by exposing a polysilane cladding layer to UV light. Our PECVD polysilane cladding is superior to other approaches, because it is insoluble, demonstrates good stability, and exhibits /spl sim/4% index shift.
Putting Mechanics into Quantum Mechanics (2005)

Nanoelectromechanical structures are starting to approach the ultimate quantum mechanical limits for detecting and exciting motion at the nanoscale. Nonclassical states of a mechanical resonator are also on the horizon.
Flexible microelectrode array for retinal prosthesis (2017)

fMEA (flexible microelectrode array) is one of the key implantable components for neural stimulating and recording. For its specific implanted environment, it should be designed and fabricated to meet following requirements such as biocompatibility, high-resolution, flexible and low impedance to ensure safety and long-term effective stimulation. Here we proposed a high resolution (1025-channel) fMEA for artificial retina. The adhesion between its substrate polyimide (PI) and metal was enhanced by using plasma treatment. The stimulation spots were electroplated with Pt-gray, which significantly reduced the electrochemical impedance from 110 kμ to 16 kμ at 1 kHz, and also provided larger charge storage capacity up to 83.2 mC/cm<sup>2</sup>. It shows a promising application for neural stimulation and recording.