gebhart/patrepeval huggingface dataset:
The potential role of tau protein O-glycosylation in Alzheimer's disease (2004)

Single O-linked N-acetylglucosamine (O-GlcNAc) sugar residues can compete with phosphate groups to occupy specific sites on certain nuclear and cytosolic proteins. Here we show that inhibiting cellular kinase activities resulted in changes in protein O-glycosylation levels in heat-stable cytoskeletal protein fractions derived from primary neuronal cells. As increased phosphorylation of the microtubule-associated protein tau is one of the pathological hallmarks of Alzheimer's disease and glycosylation may play an influential role in this process. We observed a significant decrease in the protein O-GlcNAc glycosylation of a tau-enriched cytoskeletal fraction generated from AD post-mortem brain samples as compared with control, suggesting an inverse relationship between the two post-translational modifications. Finally, cells transfected with the cDNA coding for O-GlcNAc transferase (OGT) displayed altered tau phosphorylation patterns as compared with control cells, suggesting that changes in tau glycosylation may influence its phosphorylation state. The specificity of the changes in the phosphorylation of individual amino acid residues provides evidence for a targeted O-glycosylation of tau.
Chirped circular dielectric gratings for near-unity collection efficiency from quantum emitters in bulk diamond (2017)

Effcient collection of fluorescence from nitrogen vacancy (NV) centers in diamond underlies the spin-dependent optical read-out that is necessary for quantum information processing and enhanced sensing applications. The optical collection effciency from NVs within diamond substrates is limited primarily due to the high refractive index of diamond and the non-directional dipole emission. Here we introduce a light collection strategy based on chirped, circular dielectric gratings that can be fabricated on a bulk diamond substrate to redirect an emitter’s far-field radiation pattern. Using a genetic optimization algorithm, these grating designs achieve 98.9% collection effciency for the NV zero-phonon emission line, collected from the back surface of the diamond with an objective of aperture 0.9. Across the broadband emission spectrum of the NV (600-800 nm), the chirped grating achieves 82.2% collection e ciency into a numerical aperture of 1.42, corresponding to an oil immersion objective again on the back side of the diamond. Our proposed bulk-dielectric grating structures are applicable to other optically active solid state quantum emitters in high index host materials.
Improved reliability of SiC pressure sensors for long term high temperature applications (2011)

We report advancement in the reliability of silicon carbide pressure sensors operating at 600°C for extended periods. The large temporal drifts in zero pressure offset voltage at 600°C observed previously were significantly suppressed to allow improved reliable operation. This improvement was the result of further enhancement of the electrical and mechanical integrity of the bondpad/contact metallization, and the introduction of studded bump bonding on the pad. The stud bump contact promoted strong adhesion between the Au bond pad and the Au die-attach. The changes in the zero offset voltage and bridge resistance over time at temperature were explained by the microstructure and phase changes within the contact metallization, that were analyzed with Auger electron spectroscopy (AES) and field emission scanning electron microscopy (FE-SEM).
Central nervous system pathology contributes to respiratory deficits in Glycogen Storage Disease Type II (GSDII) (2006)

GSDII is caused by deficiency of the enzyme acid α-glucosidase (GAA) and results in systemic glycogen accumulation. Respiratory deficits that accompany GSDII have been attributed to diaphragmatic muscle weakness. However, case reports suggest that motoneuron pathology is present in GSDII. Thus, we hypothesized that respiratory neural control is impaired in mice lacking GAA (Gaa−/−). Using plethysmography, breathing was quantified in Gaa−/− mice and age/gender matched controls (B6/129; Gaa−/−background strain). During quiet breathing, minute ventilation (mL/min) was attenuated (n=8/group, p<0.001) in Gaa−/− (43±4) vs. control mice (60±6). Phrenic motor output was assessed via nerve recordings in anesthetized, paralyzed, ventilated mice. Preliminary data suggest that phrenic inspiratory burst amplitude is lower (p<0.001) in Gaa−/− (0.2 ± 0.0 mV, PaCO2 = 51.5 ± 1.4 mmHg, n=3) vs. controls (15.4 ± 4.9 mV, PaCO2 = 54.5 ± 1.5 mmHg, n=2). Glycogen accumulation was quantified in the spinal segments containing phrenic motoneurons (C3-C5) via the acid hydrolysis method. Glycogen (μg/mg wet wt) was elevated (n=6/group, p<0.001) in Gaa−/− (37.6±2.4) vs. control (17.4±0.5). We conclude: 1) Gaa−/− mice recapitulate clinical GSDII respiratory deficits, 2) spinal glycogen accumulation may impair motor output, and 3) respiratory neural control may be impaired in GSDII. NIH HL59412 T32 HD043730 UF Alumni Assoc
Manipulation of skin temperature improves nocturnal sleep in narcolepsy (2008)

Subtle skin temperature manipulations under controlled conditions significantly improved the typical nocturnal sleep problems in narcolepsy.
Investigation of the Stark Effect on a Centrosymmetric Quantum Emitter in Diamond (2021)

Quantum emitters in diamond are leading optically accessible solid-state qubits. Among these, Group IV-vacancy defect centers have attracted great interest as coherent and stable optical interfaces to long-lived spin states. Theory indicates that their inversion symmetry provides first-order insensitivity to stray electric fields, a common limitation for optical coherence in any host material. Here we experimentally quantify this electric field dependence via an external electric field applied to individual tin-vacancy (SnV) centers in diamond. These measurements reveal that the permanent electric dipole moment and polarizability are at least 4 orders of magnitude smaller than for the diamond nitrogen vacancy (NV) centers, representing the first direct measurement of the inversion symmetry protection of a Group IV defect in diamond. Moreover, we show that by modulating the electric-field-induced dipole we can use the SnV as a nanoscale probe of local electric field noise, and we employ this technique to highlight the effect of spectral diffusion on the SnV.
ChemInform Abstract: Synthesis and Phase Stability of Metastable Bixbyite V2O3 Colloidal Nanocrystals. (2013)

Abstract V 2 O 3 nanocrystals with a cubic bixbyite structure are prepared from VO(acac) 2 , oleylamine, and oleic acid (N 2 flow, 310—370 °C, 1 h) and characterized by XRD, TEM, and FTIR spectroscopy.
Supplementary Methods and Figures 1-3 from Epidermal Growth Factor Receptor Tyrosine Phosphorylation and Signaling Controlled by a Nuclear Receptor Coactivator, Amplified in Breast Cancer 1 (2023)

Supplementary Methods and Figures 1-3 from Epidermal Growth Factor Receptor Tyrosine Phosphorylation and Signaling Controlled by a Nuclear Receptor Coactivator, Amplified in Breast Cancer 1
The effect of vibrotactile feedback on postural sway during locomotor activities (2013)

This preliminary study demonstrated that use of continuous vibrotactile feedback during challenging locomotor tasks allowed subjects with vestibular deficits to significantly decrease M/L RMS trunk tilt. Analysis of the results also showed that continuous feedback was superior.
24 GHz radar sensors for automotive applications (2002)

Automotive radar systems using integrated 24 GHz radar sensor techniques are currently under development (see Klotz, M. and Rohling, H., 5th International Conference on Radar Systems, 1999). This paper describes a radar network consisting of four sensors distributed behind the front bumper of an experimental car. Each single sensor measures the target range with high accuracy. A multilateration technique is used in the radar network for precise azimuth angle estimation even in multiple-target situations. The system performance is shown in real traffic situations for parking aid, stop-and-go and blind spot applications.
Si@MoS2 Core-Shell Architecture: Characterizations and Implications for Nanophotonic Applications (2021)

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Structure of the Modified Heme in Allylbenzene-Inactivated Chloroperoxidase Determined by Q-Band CW and Pulsed ENDOR (1997)

During the epoxidation of allylbenzene, chloroperoxidase (CPO) is converted to an inactive green species in which the prosthetic heme has been modified by addition of the alkene plus an oxygen atom (Dexter, A. F.; Hager, L. P. J. Am. Chem. Soc. 1995, 117, 817−818). We have used Q-band continuous wave and pulsed electron-nuclear double resonance (ENDOR) spectroscopy to study the CPO heme in situ following inactivation with allylbenzene, using samples prepared in natural isotopic abundance, with 15N-labeled enzyme, and with allylbenzene labeled with 2H or 13C in specific vinylic positions. The electron paramagnetic resonance (EPR) spectrum of the inactivated enzyme is dominated by a low-spin ferric signal (g1,2,3 = 2.32, 2.16, 1.95). 14,15N ENDOR examination of allylbenzene-inactivated CPO reveals that three nitrogens of the heme are similar, but the fourth nitrogen is markedly different, suggesting that a single pyrrole ring has been covalently modified at the unique nitrogen. These studies also reveal the orientation of the g tensor relative to the heme. 13C ENDOR of allylbenzene-inactivated CPO with 13C-labeled allylbenzene shows that the C-1 and C-2 carbons of allylbenzene are covalently connected to the heme system. 1,2H ENDOR plus mass analysis of CPO heme after inactivation with deuterated allylbenzene show that all three vinylic protons are retained in the heme adduct. No strongly-coupled exchangeable protons are observed, indicating that the axially bound water of frozen native CPO has been displaced. The 1H at the C-2 position of the alkene shows strong, mostly isotropic hyperfine coupling while the two hydrogens at the C-1 position show weak, dipolar couplings. The hyperfine tensors of 1,2H of the C-1 position of allylbenzene have been determined, and give the position of these atoms relative to the heme. These data, combined with molecular modeling calculations, have been used to deduce that the allylbenzene-bound heme of inactivated CPO is an N-alkylhemin metallocycle with C-1 of allylbenzene bonded to the pyrrole nitrogen and to obtain metrical details of its structure.
EVALUATION OF SIGN SUBSTRATES FOR USE WITH PLASTIC DRUMS (1996)

The Texas Department of Transportation (TxDOT) is revising its Barricade and Construction Standard sheets. In support of this effort, an earlier study developed a proposed set of specifications to evaluate and qualify plastic drums for use in work zones. Various plastic drums obtained from manufacturers were submitted first to static tests then crash tested to validate those results. Research findings are being incorporated into the revision of the Barricade and Construction Standard sheets. This portion of the study pertains to the evaluation of various sign substrates for use with plastic drums. The objectives of this study are to (1) identify sign substrates suitable for use with plastic drums, including sign substrates that are currently in use and new sign substrates that could potentially be used with plastic drums, particularly sign substrates made from recycled materials; (2) evaluate the selected sign substrates for safety performance when used with plastic drums; and (3) analyze the test results and recommend sign substrates for use with plastic drums. The scope of the study included a survey of commercially available sign substrates that are currently used with plastic drums and candidate new sign substrates. The selected sign substrates were acquired from the manufacturers. Static and full-scale crash tests were then conducted to evaluate the safety performance of the selected sign substrates.
Parallelization exploration of wireless applications using MPA (2010)

Digital wireless communication has played a key role in our lives for more than one decade. Over the last decade we have observed rapid increase of the variability within and in the number of standards in the wireless domain and rapidly increasing computational demand for those applications. Embedded solutions for those systems require highly flexible programmable multi-core low power Software Defined Radio (SDR) platforms. Such platforms exist, however an efficient mapping flow from the algorithmic specification towards the implementation of the algorithm is lacking.
Estimating the harms and benefits of prostate cancer screening as used in common practice versus recommended good practice: A microsimulation screening analysis (2016)

Commonly used PSA screening and treatment practices are associated with little net benefit. Following a few straightforward clinical recommendations, particularly greater use of active surveillance for low-risk disease and reducing screening in older men, would lead to an almost 4-fold increase in the net benefit of prostate cancer screening. Cancer 2016;122:3386-3393. © 2016 American Cancer Society.
Staphylococcus aureus from Subclinical Cases of Mastitis in Dairy Cattle in Poland, What Are They Hiding? Antibiotic Resistance and Virulence Profile (2022)

Bovine mastitis is a common disease worldwide, and staphylococci are one of the most important etiological factors of this disease. Staphylococcus aureus show adaptability to new conditions, by which monitoring their virulence and antibiotic resistance mechanisms is extremely important, as it can lead to the development of new therapies and prevention programs. In this study, we analyzed Staphylococcus aureus (n = 28) obtained from dairy cattle with subclinical mastitis in Poland. The sensitivity of the isolated strains to antibiotics were confirmed by the disc diffusion method. Additionally, minimum inhibitory concentration values were determined for vancomycin, cefoxitin and oxacillin. Genotyping was performed by two methods: PCR melting profile and MLVF-PCR (multiple-locus variable-number tandem-repeat fingerprinting). Furthermore, the presence of antibiotic resistance and virulence genes were checked using PCR reactions. The analyzed strains showed the greatest resistance to penicillin (57%), oxytetracycline (25%) and tetracycline (18%). Among the analyzed staphylococci, the presence of 9 of 15 selected virulence-related genes was confirmed, of which the icaD, clfB and sea genes were confirmed in all staphylococci. Biofilm was observed in the great majority of the analyzed bacteria (at least 70%). In the case of genotyping among the analyzed staphylococci (combined analysis of results from two methods), 14 patterns were distinguished, of which type 2 was the dominant one (n = 10). This study provides new data that highlights the importance of the dominance of biofilm over antibiotic resistance among the analyzed strains.
Large voltage-induced coercivity change in Pt/Co/CoO/amorphous TiOx structure and heavy metal insertion effect (2021)

There is urgent need for spintronics materials exhibiting a large voltage modulation effect to fulfill the great demand for high-speed, low-power-consumption information processing systems. Fcc-Co (111)-based systems are a promising option for research on the voltage effect, on account of their large perpendicular magnetic anisotropy (PMA) and high degree of freedom in structure. Aiming to observe a large voltage effect in a fcc-Co (111)-based system at room temperature, we investigated the voltage-induced coercivity (H<sub>c</sub>) change of perpendicularly magnetized Pt/heavy metal/Co/CoO/amorphous TiO<sub>x</sub> structures. The thin CoO layer in the structure was the result of the surface oxidation of Co. We observed a large voltage-induced H<sub>c</sub> change of 20.2 mT by applying 2 V (0.32 V/nm) to a sample without heavy metal insertion, and an H<sub>c</sub> change of 15.4 mT by applying 1.8 V (0.29 V/nm) to an Ir-inserted sample. The relative thick Co thickness, Co surface oxidation, and large dielectric constant of TiO<sub>x</sub> layer could be related to the large voltage-induced H<sub>c</sub> change. Furthermore, we demonstrated the separate adjustment of H<sub>c</sub> and a voltage-induced H<sub>c</sub> change by utilizing both upper and lower interfaces of Co.
Bolt-Load Retention Behavior of Die-Cast AZ91D and AE42 Magnesium (1998)

&lt;div class="htmlview paragraph"&gt;The effect of temperature and preload on the bolt load retention (BLR) behavior of AZ91D and AE42 magnesium die castings was investigated. The results were compared to those of 380 aluminum die castings. Test temperatures from 125 to 175°C and preloads from 7 to 28 kN were investigated. The loss of preload for AZ91D was more sensitive to temperature than that observed for AE42, especially at low preloads. In general, retained bolt-load was lowest in AZ91D. All test assemblies were preloaded at room temperature and load levels increased when the assemblies reached test temperature. The load-increase was dependent on the preload level, test temperature, alloy, and results from thermal expansion mismatch between the steel bolt and the magnesium alloy components, mitigated by the onset of primary creep. Thermal exposure (aging) of AZ91D at 150°C improved BLR behavior.&lt;/div&gt;
Carrier Properties of a Protein Derived from Outer Membrane Protein A ofKlebsiella pneumoniae (1999)

We have recently cloned a new protein, recombinant P40 (rP40). When tested in vivo after conjugation to a B-cell epitope, rP40 induces an important antibody response without the need for adjuvant. To characterize its potency, this carrier protein was coupled to a peptide derived from respiratory syncytial virus attachment G protein (G1'). After immunization of mice with the rP40-G1' conjugate, strong antipeptide antibodies were detected, whereas peptide alone was not immunogenic. To emphasize the carrier properties of rP40, a polysaccharide derived from Haemophilus influenzae type b (Hib) was coupled to it. Immunoglobulin G responses against the Hib polysaccharide were observed after coupling to rP40. Interestingly, an antipeptide antibody response was observed despite preexisting anti-rP40 antibodies generated by preimmunization with rP40. In addition, rP40 compares well with the reference carrier protein, tetanus toxoid (TT), since antibody responses of equal intensity were observed when a peptide or a polysaccharide was coupled to TT and rP40. Moreover, rP40 had advantages compared to TT; e.g., it induced a mixed Th1/Th2 response, whereas TT induced only a Th2 profile. Together, the results indicate that rP40 is a novel carrier protein with potential for use as an alternative carrier for human vaccination.
Understanding the Solvent Effect on the Catalytic Oxidation of 1,4‐Butanediol in Methanol over Au/TiO2 Catalyst: NMR Diffusion and Relaxation Studies (2012)

The effect of water on the catalytic oxidation of 1,4-butanediol in methanol over Au/TiO(2) has been investigated by catalytic reaction studies and NMR diffusion and relaxation studies. The addition of water to the dry catalytic system led to a decrease of both conversion and selectivity towards dimethyl succinate. Pulsed-field gradient (PFG)-NMR spectroscopy was used to assess the effect of water addition on the effective self-diffusivity of the reactant within the catalyst. NMR relaxation studies were also carried out to probe the strength of surface interaction of the reactant in the absence and presence of water. PFG-NMR studies revealed that the addition of water to the initial system, although increasing the dilution of the system, leads to a significant decrease of effective diffusion rate of the reactant within the catalyst. From T(1) and T(2) relaxation measurements it was possible to infer the strength of surface interaction of the reactant with the catalyst surface. The addition of water was found to inhibit the adsorption of the reactant over the catalyst surface, with the T(1)/T(2) ratio of 1,4-butanediol decreasing significantly when water was added. The results overall suggest that both the decrease of diffusion rate and adsorption strength of the reactant within the catalyst, due to water addition, limits the access of reactant molecules to the catalytic sites, which results in a decrease of reaction rate and conversion.
Complex formation in polymer-ion solutions. 2. Polyelectrolyte effects (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComplex formation in polymer-ion solutions. 2. Polyelectrolyte effectsE. Pezron, Ludwik Leibler, and F. LafumaCite this: Macromolecules 1989, 22, 6, 2656–2662Publication Date (Print):June 1, 1989Publication History Published online1 May 2002Published inissue 1 June 1989https://doi.org/10.1021/ma00196a021RIGHTS & PERMISSIONSArticle Views395Altmetric-Citations53LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (779 KB) Get e-Alerts Get e-Alerts
Fiber-optic tunable microwave transversal filter (1995)

A fiber-optic finite impulse response filter with continuously tunable unit time delays is developed and studied. The filter consists of eight taps with progressively longer segments of high-dispersion fiber, but completed with dispersion-shifted fiber to nominally identical overall lengths. The time delays through each tap are tuned by varying the wavelength of the optical carrier. The constructed 8-tap filter exhibits bandpass characteristics with a Q of 30. The bandpass band is continuously tuned over a full octave from under 9 GHz to over 18 GHz with a single low-voltage control signal that demonstrates the technique's applicability to adaptive systems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>