gebhart/patrepeval huggingface dataset:
Effects of Charge Balance and Exciton Confinement on the Operational Lifetime of Blue Phosphorescent Organic Light-Emitting Diodes (2017)

For 15 years, the rapid degradation of luminance over time has rendered blue phosphorescent light emitting diodes (PHOLEDs) too short-lived for many practical applications. To date, studies have concentrated on the degradation of the emitting materials, yet not the many other parts of these devices. The authors develop a method to measure charge and exciton leakage directly over time, and find that these effects are $n\phantom{\rule{0}{0ex}}o\phantom{\rule{0}{0ex}}t$ responsible for PHOLED degradation---an important revelation that shifts our attention toward the actual sources of failure.
HD12 Randomised Trial Comparing 8 Dose-Escalated Cycles of BEACOPP with 4 Escalated and 4 Baseline Cycles in Patients with Advanced Stage Hodgkin Lymphoma (HL): An Analysis of the German Hodgkin Lymphoma Study Group (GHSG), University of Cologne, D-50924 Cologne, Germany. (2006)

Abstract The preceding trial HD9 had shown a significant superiority for escalated BEACOPP (EB) for failure-free survival (FFTF) and overall survival (OS) over COPP/ABVD or baseline BEACOPP (BB) (each 8 cycles). HD12 aimed to de-escalate chemotherapy by comparing 8 cycles EB with 4 cycles EB plus 4 cycles BB, with or without consolidatory 30 Gy radiation (RT) to initial bulky and residual disease. A total of 1661 patients aged 16–65 with HL in stage IIB (large mediastinal mass and/or E-lesions) or stage III-IV were randomised from 9/1999-1/2003 according to a factorial design between: 8EB + RT, 8EB no RT, 4EB+4BB + RT, 4EB+4BB no RT. A central diagnostic panel reviewed CT images after completion of chemotherapy independent of randomisation arm, and prescribed RT in selected cases. In the fifth analysis of HD12 (5/2006), 94% of all 1593 eligible randomised patients were evaluable, including 1498 for the chemotherapy comparison and 1449 for the radiotherapy comparison. Patient characteristics were very similar for all 4 arms. Radiation was given in arms with planned RT in 65%, in arms with no planned RT in 10%. 93% of all patients reached a complete remission, 2.2% suffered early progression, 4.6% relapsed and 8.2% died with a median folllow-up time of 48 months. Death due to acute toxicity was 3.2% (sepsis, cardiac, pulmonary, infection), with 21 such deaths in the 8EB arms and 27 in the 4EB+4BB arms. Secondary neoplasias were observed in 55 patients (3.7%): 14 AML/MDS, 12 NHL and 29 solid tumors/others. Four-year Kaplan-Meier estimates for arm pairs according to the factorial design were: 4 year rates, %(95% CI) 8EB vs. 4EB+4BB with RT vs. without RT FFTF 88(86–91) 86(83–89) 91(89–93) 88(86–91) OS 93(91–95) 91(89–93) No significant differences were observed when comparing treatments according to the sequential analysis plan (N.B. 10% received RT in arms ‘without RT’). The final analysis, scheduled when 80% of patients have 5 years follow-up, must be awaited before final conclusions can be drawn.
The Significance of Simultaneous Transurethral Resection of Bladder Tumor and the Prostate in Patient who have Superficial Bladder Cancer with Bladder Outlet Obstruction (2008)

PURPOSE: We evaluated the clinical significance of simultaneous transurethral resection of bladder tumor(TURB) and the prostate(TURP) in patients who have superficial bladder cancer with bladder outlet obstruction. MATERIALS AND METHODS: Between April 1997 to April 2006, 213 patients with superficial bladder cancer were included in this study. The patients were treated with TURB only(n=107, Group I) or TURB with TURP (n=106, Group II). Bladder cancer recurrence was observed by performing cystoscopy and urine cytology. Uroflowmetry was performed three months after surgery. RESULTS: There were no significant differences in age, the tumor size or the number of tumors between groups I and II. There was no evidence of cancer implantation where TURP was applied. The recurrence rate of group II was significantly lower than that of group I(p=0.044), and the time to recurrence was longer for group II than for group I(p=0.026). There was no significant difference in the progression rate between the two groups(p=0.788). Three months after surgery, the mean residual urine volume was lower for group II(7.9ml) than that for group I(21.7ml). CONCLUSIONS: For superficial bladder cancer patients with bladder outlet obstruction, simultaneous TURB and TURP may help reduce the bladder cancer recurrence rate and delay the time to recurrence without the risk of cancer implantation at the site where TURP is applied.
Association of Lupuslike Anticoagulant and Nonvasculitic Cerebral Infarction (1986)

The lupus anticoagulant has been theoretically linked with cerebrovascular dysfunction. All previously described patients, however, have had other concomitant conditions known to predispose them to stroke. The patient described herein demonstrates the association of a lupuslike anticoagulant with thrombotic vascular occlusion in the central nervous system in the absence of other causes of vasculopathy.
Higher-Order Threshold Implementation Of The Aes S-Box (2015)

In this paper we present a threshold implementation of the Advanced Encryption Standard’s S-box which is secure against first- and second-order power analysis attacks. This security guarantee holds even in the presence of glitches, and includes resistance against bivariate attacks. The design requires an area of 7849 Gate Equivalents and 126 bits of randomness per S-box execution. The implementation is tested on an FPGA platform and its security claim is supported by practical leakage detection tests.
Tyrosine Phosphorylation Profiling Revealed the Signaling Network Characteristics of CAMKK2 in Gastric Adenocarcinoma (2022)

Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) is a serine/threonine protein kinase which functions <i>via</i> the calcium-triggered signaling cascade with CAMK1, CAMK4, and AMPKα as the immediate downstream substrates. CAMKK2 is reported to be overexpressed in gastric cancer; however, its signaling mechanism is poorly understood. We carried out label-free quantitative tyrosine phosphoproteomics to investigate tyrosine-mediated molecular signaling associated with CAMKK2 in gastric cancer cells. Using a high-resolution Orbitrap Fusion Tribrid Fourier-transform mass spectrometer, we identified 350 phosphotyrosine sites mapping to 157 proteins. We observed significant alterations in 81 phosphopeptides corresponding to 63 proteins upon inhibition of CAMKK2, among which 16 peptides were hyperphosphorylated corresponding to 13 proteins and 65 peptides were hypophosphorylated corresponding to 51 proteins. We report here that the inhibition of CAMKK2 leads to changes in the phosphorylation of several tyrosine kinases such as PKP2, PTK2, EPHA1, EPHA2, PRKCD, MAPK12, among others. Pathway analyses revealed that proteins are differentially phosphorylated in response to CAMKK2 inhibition involved in focal adhesions, actin cytoskeleton, axon guidance, and signaling by VEGF. The western blot analysis upon inhibition and/or silencing of CAMKK2 revealed a decrease in phosphorylation of PTK2 at Y925, c-JUN at S73, and STAT3 at Y705, which was in concordance with the mass spectrometry data. The study indicates that inhibition of CAMKK2 has an anti-oncogenic effect in gastric cells regulating phosphorylation of STAT3 through PTK2/c-JUN in gastric cancer.
13.5-inch quarter high definition white tandem OLED display using crystalline In-Ga-Zn-Oxide technology (2012)

We devised a 6Tr+2C pixel circuit having a threshold voltage compensation function for large-sized OLED displays, and fabricated a 13.5-inch quarter high definition (qHD) OLED display using the pixel. The display device has bottom-emission white tandem OLEDs and a color-filter-on-array structure. The scan driver is integrated on glass.
Interactions between cilazapril and propranolol in man; plasma drug concentrations, hormone and enzyme responses, haemodynamics, agonist dose‐effect curves and baroreceptor reflex. (1988)

1. The pharmacokinetics, hormonal and haemodynamic responses at rest and during challenges with angiotensin I (blood pressure), isoprenaline (heart rate), and noradrenaline (blood pressure) were investigated in six healthy male volunteers following a 1 week treatment with placebo, propranolol (120 mg day-1), cilazapril (2, 5 mg day-1), and a combination of both in a double-blind cross-over design. 2. Both drugs reduced systolic and diastolic blood pressure by about 7 mm Hg as compared with placebo. After coadministration, this drop in blood pressure was doubled and lasted longer than after the administration of the individual components. 3. Following cilazapril, a pronounced increase in plasma renin activity (PRA) was found (factor approximately 10 at drug peak concentrations). Coadministration of both drugs resulted only in a moderate increase in the PRA (factor approximately 3). Significant changes in plasma catecholamines were not observed. 4. Propranolol shifted the isoprenaline dose-effect curve to the right, and cilazapril that of angiotensin I, irrespective of the presence of the other drug. Cilazapril tended to shift the noradrenaline dose-effect curve somewhat to the right. 5. The gain of the baroreceptor reflex (angiotensin-stimulation) was not influenced by cilazapril but was lowered by propranolol, irrespective of the presence of the ACE inhibitor. 6. Except for a statistically not significant decrease in the peak concentrations of each drug during the combined therapy, a pharmacokinetic interaction between the two drugs was not found.
Human CD4+CD8α+ Tregs induced by Faecalibacterium prausnitzii protect against intestinal inflammation (2022)

Abundance of Faecalibacterium prausnitzii, a dominant bacterium of the human microbiota that exhibits antiinflammatory effects, is decreased in patients with inflammatory bowel diseases (IBD). In humans, colonic lamina propria contains IL-10-secreting, Foxp3- Tregs characterized by a double expression of CD4 and CD8α (DP8α) and a specificity for F. prausnitzii. This Treg subset is decreased in IBD. The in vivo effect of DP8α cells has not been evaluated yet to our knowledge. Here, using a humanized model of a NSG immunodeficient mouse strain that expresses the HLA D-related allele HLA-DR*0401 but not murine class II (NSG-Ab° DR4) molecules, we demonstrated a protective effect of a HLA-DR*0401-restricted DP8α Treg clone combined with F. prausnitzii administration in a colitis model. In a cohort of patients with IBD, we showed an independent association between the frequency of circulating DP8α cells and disease activity. Finally, we pointed out a positive correlation between F. prausnitzii-specific DP8α Tregs and the amount of F. prausnitzii in fecal microbiota in healthy individuals and patients with ileal Crohn's disease.
Human vs. robot operator error in a needle-based navigation system for percutaneous liver interventions (2009)

Computed tomography (CT) guided percutaneous punctures of the liver for cancer diagnosis and therapy (e.g. tumor biopsy, radiofrequency ablation) are well-established procedures in clinical routine. One of the main challenges related to these interventions is the accurate placement of the needle within the lesion. Several navigation concepts have been introduced to compensate for organ shift and deformation in real-time, yet, the operator error remains an important factor influencing the overall accuracy of the developed systems. The aim of this study was to investigate whether the operator error and, thus, the overall insertion error of an existing navigation system could be further reduced by replacing the user with the medical robot Robopsy. For this purpose, we performed navigated needle insertions in a static abdominal phantom as well as in a respiratory liver motion simulator and compared the human operator error with the targeting error performed by the robot. According to the results, the Robopsy driven needle insertion system is able to more accurately align the needle and insert it along its axis compared to a human operator. Integration of the robot into the current navigation system could thus improve targeting accuracy in clinical use.
Biochemical Systematics of the Peromyscus boylii Species Group (1991)

Allelic variation at 32 loci was examined among forms of the Peromyscus aztecus and P. boylii assemblages of the P. boylii species group, representative taxa of the P. truei and P. leucopus species groups, and P. eremicus of the subgenus Haplomylomys to examine conflicting hypotheses regarding the monophlyetic or polyphyletic nature of the P. boylii species group. Twenty-three loci exhibited intraspecific or interspecific variation. Although phenetic analysis of the biochemical data suggested that the P. boylii species group is polyphyletic, neither the phenetic nor the cladistic analyses supported the recent chromosomally based hypothesis that allied the P. aztecus assemblage with the P. leucopus species group. With exception of P. pectoralis, the P. boylii group taxa genetically appeared to form a monophyletic group.
Multi-agent stochastic control: models inspired from quantum physics (2004)

In this paper, we consider multi-agent stochastic optimization and control problems, with partial information. The agent can operate in a distributed and asynchronous fashion. We investigate new problems that arise out of the interaction between observations and control actions by the agent. We show that new non-classical and non-commutative probability models are needed in order to properly formulate such problems. The models we develop here are inspired by models developed for dynamical physics problems. We establish a series of fundamental results for the trade-off between information and control patterns in distributed stochastic control, detection and estimation.
Down-regulation of surface antigens recognized by systemic lupus erythematosus antibodies on embryonal cells following differentiation and exposure to corticosteroids (1998)

We have previously suggested that anti-DNA antibodies present in systemic lupus erythematosus patients can bind directly to tissues as a result of cross-reactivity with embryonal tissue-based antigens. Here we have analyzed the interaction between polyclonal and monoclonal mouse and human lupus autoantibodies and an embryonal cell line. We report that a murine embryonal stem cell line (ES) expresses a surface antigen which is recognized by mouse and human lupus autoantibodies. This surface antigen is down-regulated following maturation of the cells or incubation with corticosteroids. Adhesion molecules may serve as the target membrane antigen in ES cells since preincubation with these antibodies decreases the ability of ES cells to adhere to the plate.
Acetylenic Pyridines for Use in PET Imaging of Nicotinic Receptors (2006)

Getting a better view: 11C- and 18F-labeled derivatives of the α4β2-selective, acetylene-bearing analogue of A-84543 were prepared and examined for their use as diagnostic tools in the PET imaging of nicotinic receptors in baboons. These agents may find use in determining nicotinic receptor changes in certain neurological disorders.
Broadband absorption enhancement in ultra‐thin crystalline Si solar cells by incorporating metallic and dielectric nanostructures in the back reflector (2014)

Abstract We propose a back reflecting scheme in order to enhance the maximum achievable current in one micron thick crystalline silicon solar cells. We perform 3D numerical investigations of the scattering properties of metallic nanostructures located at the back side and optimize them for enhancing absorption in the silicon layer. We validate our numerical results experimentally and also compare the absorption enhancement in the solar cell structure, both with quasi‐periodic and random metallic nanostructures. We have looked at the interplay between the metallic nanostructures and an integrated back reflector. We show that the combination of metallic nanoparticles and a metallic reflector results in significant parasitic absorption. We compared this to another implementation based on titanium dioxide nanoparticles, which act as a Lambertian reflector of light. Our simulation and experimental results show that this proposed configuration results in reduced absorption losses and in broadband enhancement of absorption for ultra‐thin solar cells, paving the way to an optimal back reflector for thin film photovoltaics. Copyright © 2014 John Wiley &amp; Sons, Ltd.
Unveiling Emitter Wavefunction Size via the Quantum Coherence of its Radiation (2020)

We sttudy the fundamental influence of an emitter's wavefunction on the coherence of its electromagnetic radiation. Our findings allow for a new method to measure the wavefunction dimensions of charged quanttum particles.
Investigation of the impact of transient heat loads applied by laser irradiation on ITER-grade tungsten (2014)

Cracking thresholds and crack patterns in tungsten targets after repetitive ITER-like edge localized mode (ELM) pulses have been studied in recent simulation experiments by laser irradiation. The tungsten specimens were tested under selected conditions to quantify the thermal shock response. A Nd:YAG laser capable of delivering up to 32 J of energy per pulse with a duration of 1 ms at the fundamental wavelength λ = 1064 nm has been used to irradiate ITER-grade tungsten samples with repetitive heat loads. The laser exposures were performed for targets at room temperature (RT) as well as for targets preheated to 400 °C to measure the effects of the ELM-like loading conditions on the formation and development of cracks. The magnitude of the heat loads was 0.19, 0.38, 0.76 and 0.90 MJ m−2 (below the melting threshold) with a pulse duration of 1 ms. The tungsten surface was analysed after 100 and 1000 laser pulses to investigate the influence of material modification by plasma exposures on the cracking threshold. The observed damage threshold for ITER-grade W lies between 0.38 and 0.76 GW m−2. Continued cycling up to 1000 pulses at RT results in enhanced erosion of crack edges and crack edge melting. At the base temperature of 400 °C, the formation of cracks is suppressed.
Activation of matrix metalloproteinases and FoxO3a in HaCaT keratinocytes by radiofrequency electromagnetic field exposure (2021)

As the skin is the largest body organ and critically serves as a barrier, it is frequently exposed and could be physiologically affected by radiofrequency electromagnetic field (RF-EMF) exposure. In this study, we found that 1760 MHz RF-EMF (4.0 W/kg specific absorption rate for 2 h/day during 4 days) exposure could induce intracellular reactive oxygen species (ROS) production in HaCaT human keratinocytes using 2',7'-dichlorofluorescin diacetate fluorescent probe analysis. However, cell growth and viability were unaffected by RF-EMF exposure. Since oxidative stress in the skin greatly influences the skin-aging process, we analyzed the skin senescence-related factors activated by ROS generation. Matrix metalloproteinases 1, 3, and 7 (MMP1, MMP3, and MMP7), the main skin wrinkle-related proteins, were significantly increased in HaCaT cells after RF-EMF exposure. Additionally, the gelatinolytic activities of secreted MMP2 and MMP9 were also increased by RF-EMF exposure. FoxO3a (Ser318/321) and ERK1/2 (Thr 202/Tyr 204) phosphorylation levels were significantly increased by RF-EMF exposure. However, Bcl2 and Bax expression levels were not significantly changed, indicating that the apoptotic pathway was not activated in keratinocytes following RF-EMF exposure. In summary, our findings show that exposure to 1760 MHz RF-EMF induces ROS generation, leading to MMP activation and FoxO3a and ERK1/2 phosphorylation. These data suggest that RF-EMF exposure induces cellular senescence of skin cells through ROS induction in HaCaT human keratinocytes.
Cardiopoietic cell therapy for advanced ischemic heart failure: results at 39 weeks of the prospective, randomized, double blind, sham-controlled CHART-1 clinical trial (2016)

The primary endpoint was neutral, with safety demonstrated across the cohort. Further evaluation of cardiopoietic cell therapy in patients with elevated end-diastolic volume is warranted.
Characterization of cholecystokinin receptor subunits on pancreatic plasma membranes. (1983)

To determine the size and subunit structure of the pancreatic cholecystokinin (CCK) receptor, 125I-CCK33 was covalently cross-linked to its receptor on mouse pancreatic acinar plasma membranes utilizing the bifunctional cross-linker disuccinimidyl suberate. When CCK was cross-linked at pH 7.4 to either purified plasma membranes or to isolated pancreatic acini and then followed by preparation of plasma membranes, the major labeled protein band revealed by polyacrylamide gel electrophoresis was Mr = 120,000 in the absence of reducing agent and Mr = 80,000 in the presence of reducing agent. A similar banding pattern was also observed when different cross-linkers, ethylene glycol bis(succinimidyl succinate) or dithiobis (succinimidyl propionate), were employed. At pH 6.0, where CCK binding to its receptors is optimal, the labeling pattern was similar to that seen at 7.4, although the two bands were more heavily labeled. Both the binding of CCK to its receptors on plasma membranes and the appearance of the two cross-linked proteins on gels were inhibited in a parallel manner by increasing concentrations of unlabeled CCK8; similar results were observed with dibutyryl cyclic GMP, a competitive inhibitor of CCK binding and action. The data indicate, therefore, that the CCK receptor possesses subunit structure whereby an Mr = 76,000 binding subunit is linked to an Mr = 40,000 nonbinding subunit by a disulfide bond.
Electric Vehicles for Smart Buildings: A Survey on Applications, Energy Management Methods, and Battery Degradation (2020)

Plug-in electric vehicles (PEVs) have the highest promise for dramatically reducing transportation emissions. No other option has comparable emission reduction potential or as a promising pathway. Still, PEVs can offer more than green transportation. In particular, their onboard storage can further serve the society by providing an energy buffer to increase the reliability, affordability, and sustainability of electric services. These benefits are only achievable by fully exploiting the multifaceted flexibility provided by PEVs' mobility, charging adaptability, and bidirectional flow of power, as well as adopting effective decision-making and control algorithms, while minding the likely unfavorable side effects, such as shortened battery life span. This work takes a closer look at different elements of this puzzle. The main subject of this survey is behind the meter energy management with vehicle to building (V2B). We focus on different V2B application ideas and review energy management methods in smart buildings with V2B integration. Recent findings on battery capacity fade resulting from the bidirectional flow of power and extra discharging cycles with V2B are reviewed, and the methods for integrating the battery degradation in energy management formulation are discussed. Finally, the main findings of this review and research gaps are summarized and clarified.
High field insulation relevant to vacuum microelectronic devices (2002)

This paper briefly introduces our recent results on high field vacuum insulation relevant to vacuum microelectronics. It addresses the key factors that contribute to the failure of the vacuum gap insulation. Approaches to the development of specific solutions to improve the vacuum gap breakdown voltages are presented. Solutions to alleviate the edge breakdown effect in the thin-film vacuum gap and to inhibit the formation of electrical activity in the spacer triple junction area were proven to be very effective in improving the vacuum insulation performance of vacuum microelectronics. The influence of the presence of an electron beam on the plain-vacuum-gap insulation is also reported.