gebhart/patrepeval huggingface dataset:
Compact Modeling of Short-Channel Effects in Staggered Organic Thin-Film Transistors (2020)

This article introduces analytical compact models of short-channel effects in staggered organic thin-film transistors (TFTs). The effects of subthreshold-swing degradation, threshold-voltage roll-off, and drain-induced barrier lowering (DIBL) on the static current-voltage characteristics of staggered TFTs are extracted from an analytical potential solution of the 2-D problem of the staggered geometry. This solution is derived by using the Schwarz-Christoffel transformation that leads to a complex mapping function linking the staggered geometry to an equivalent in another coordinate system for which an analytical potential solution exists. The technology CAD (TCAD) Software Sentaurus is used to verify the compact models. Finally, the closed-form and physics-based equations are incorporated into an existing compact current model and verified by measurements on staggered organic TFTs with channel lengths as small as 0.4 μm fabricated on flexible plastic substrates by stencil lithography.
Rapid confirmation of single copy lambda prophage integration by PCR (1994)

Journal Article Rapid confirmation of single copy lambda prophage integration by PCR Get access Bradford S. Powell, Bradford S. Powell 1Laboratory of Chromosome Biology, ABL-Basic Research Program, NCI-Frederick Cancer Research and Development CenterFrederick, MD 21702-12013Department of Tumor Biology, The Institute of Medical Science, The University of TokyoPO Takanawa 108, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Donald L. Court, Donald L. Court * 1Laboratory of Chromosome Biology, ABL-Basic Research Program, NCI-Frederick Cancer Research and Development CenterFrederick, MD 21702-1201 *To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar Yoshikazu Nakamura, Yoshikazu Nakamura 3Department of Tumor Biology, The Institute of Medical Science, The University of TokyoPO Takanawa 108, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Marcos P. Rivas, Marcos P. Rivas 2Department of Microbiology, University of Alabama at BirminghamBirmingham, AL 35294-2170, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Charles L. Turnbough, Jr Charles L. Turnbough, Jr 2Department of Microbiology, University of Alabama at BirminghamBirmingham, AL 35294-2170, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 22, Issue 25, 25 December 1994, Pages 5765–5766, https://doi.org/10.1093/nar/22.25.5765 Published: 01 January 1994 Article history Published: 01 January 1994 Received: 03 October 1994 Accepted: 11 November 1994
STRESS DISTRIBUTION IN CROSS-SECTION OF RC COLUMN (2009)

Experiment by authors showed that lateral strain at the center in a real size column using ultra high-strength concrete was larger than longitudinal one. This phenomenon indicates that stress, which may cause longitudinal crack, is produced in the RC column when the isotropic autogenous shrinkage is assumed. Based on this experimental facts, 3-dimensional finite element method which takes account of temperature dependent autogenous shrinkage is conducted for evaluating stress in the RC column. As a result, it is numerically confirmed that temperature history and autogenous shrinkage produces self-induced stress in cross-section which is vertical to longitudinal direction of RC column.
Anti‐EF‐Tu IgG titers increase with age and may contribute to protection against the respiratory pathogen Haemophilus influenzae (2018)

Non-typeable Haemophilus influenzae (NTHi) is a pathogen that commonly colonizes the nasopharynx of preschool children, causing opportunistic infections including acute otitis media (AOM). Patients suffering from chronic obstructive pulmonary disease (COPD) are persistently colonized with NTHi and occasionally suffer from exacerbations by the bacterium leading to increased morbidity. Elongation-factor thermo unstable (EF-Tu), a protein critical for bacterial protein synthesis, has been found to moonlight on the surface of several bacteria. Here, we show that antibodies against NTHi EF-Tu were present in children already at 18 months of age, and that the IgG antibody titers increased with age. Children harboring NTHi in the nasopharynx also displayed significantly higher IgG concentrations. Interestingly, children suffering from AOM had significantly higher anti-EF-Tu IgG levels when NTHi was the causative agent. Human sera recognized mainly the central and C-terminal part of the EF-Tu molecule and peptide-based epitope mapping confirmed similar binding patterns for sera from humans and immunized mice. Immunization of BALB/c and otitis-prone Junbo (C3H/HeH) mice promoted lower infection rates in the nasopharynx and middle ear, respectively. In conclusion, our results suggest that IgG directed against NTHi EF-Tu may play an important role in the host immune response against NTHi.
Histopathological features and their prognostic impact in nodular lymphocyte‐predominant Hodgkin lymphoma – a matched pair analysis from the German Hodgkin Study Group (GHSG) (2014)

Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare lymphoma entity. We performed a matched-pair analysis to evaluate the prognostic impact of several histopathological features in this distinct Hodgkin lymphoma subtype. Lymph node samples of NLPHL patients were tested for CD15, IgD, phosphorylated STAT6, ICOS and Epstein-Barr virus status of the malignant lymphocyte-predominant cells as well as epithelioid cell clusters and activated T cells in the microenvironment. None of these features was associated with a particular clinical outcome. However, patients presenting with epithelioid cell clusters showed a non-significant trend towards a lower relapse rate, justifying further evaluation of this marker.
In-vivo PET imaging of inducible D2R reporter transgene expression using [11C]FLB 457 as reporter probe in living rats (2005)

The D2R-FLB 457 reporter gene-reporter probe system should be considered as a useful technique for measuring inducible in-vivo gene expression.
Design methodology for a 1.0 GHz microprocessor (2002)

This paper describes the design methodology used to build an experimental 1.0 GigaHertz PowerPC integer microprocessor at IBM's Austin Research Laboratory. The high frequency requirements dictated the chip composition to be almost entirely custom macros using dynamic circuit techniques. The methodology presented will cover design and verification tools as well as circuit constraints and microarchitecture philosophy. The microarchitecture, circuits and tools were defined by the high frequency requirements of the processor as well as the aggressive design schedule and size of the design team.
Spectral Induced Polarization Measurements on Unsaturated, Unconsolidated Sediments (2002)

PreviousNext No AccessSymposium on the Application of Geophysics to Engineering and Environmental Problems 2002Spectral Induced Polarization Measurements on Unsaturated, Unconsolidated SedimentsAuthors: Craig UlrichLee SlaterCraig UlrichDepartment of Geosciences, UMKC, Kansas City, MO and Lee SlaterDepartment of Geosciences, UMKC, Kansas City, MOhttps://doi.org/10.4133/1.2927170 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Abstract Introductory paragraph for this paper is available only in the PDF and GZipped PS filesPermalink: https://doi.org/10.4133/1.2927170FiguresReferencesRelatedDetails Symposium on the Application of Geophysics to Engineering and Environmental Problems 2002ISSN (online):1554-8015Copyright: 2002 Pages: publication data© 2002 Copyright © 2002 The Environmental and Engineering Geophysical SocietyPublisher:Environmental & Engineering Geophysical Society HistoryPublished: 30 Sep 2008 CITATION INFORMATION Craig Ulrich and Lee Slater, (2002), "Spectral Induced Polarization Measurements on Unsaturated, Unconsolidated Sediments," Symposium on the Application of Geophysics to Engineering and Environmental Problems Proceedings : PET4-PET4. https://doi.org/10.4133/1.2927170 Plain-Language Summary PDF DownloadLoading ...
ChemInform Abstract: S‐2,4,6‐Trimethoxybenzyl (Tmob): A Novel Cysteine Protecting Group for the Nα‐9‐Fluorenylmethoxycarbonyl (Fmoc) Strategy of Peptide Synthesis. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Synthesis of the C1‘−C11‘ Oxazole-Containing Side Chain of Leucascandrolide A. Application of a Sonogashira Cross-Coupling (2002)

An efficient, convergent synthesis of the C1'-C11' side chain (3) of leucascandrolide A (1) has been achieved. The key bond connection is made through the use of a palladium(0)-catalyzed Sonogashira cross-coupling between trifloyl oxazole (4) and alkynylmetal species (5).
National External Quality Assessment Scheme for Lymphocyte Immunophenotyping in Belgium (2003)

In 2000, the Belgian Scientific Institute of Public Health introduced a voluntary external quality assessment scheme for lymphocyte immunophenotyping. This paper provides an analysis of the first six surveys. Specimens consisted of fresh EDTA-anticoagulated whole blood and were sent by overnight mail. The 41 participants were surveyed for methodology and were asked to report white blood cell count, percentage of lymphocytes, and percentages and absolute numbers of CD3+, CD4+, CD8+, and CD19+ cells. Median intralaboratory coefficients of variation were 1.0, 1.3, 1.7, and 3.2% for CD3+, CD4+, CD8+, and CD19+ cell percentages, respectively. Interlaboratory variability was consistently lower than 6.5% for CD3+ and CD4+CD3+ cell percentages, and lower than 9.5% for CD8+CD3+ cell percentages. Median coefficients of variation for the absolute values were higher, ranging from 10.1% for CD4+CD3+ cells to 16.5% for CD19+ cells. The percentage of CD4+CD3+ and CD8+ CD3+ cells was in several samples significantly lower than the percentage of total CD4+ and CD8+ cells. The number of laboratories measuring total CD4+ and CD8+ cells decreased by 30% during the programme. Between-laboratory variability remained stable over time. Analysis of individual laboratory performance indicated that some laboratories markedly improved their results.
Imaging Cerenkov emission as a quality assurance tool in electron radiotherapy (2014)

A new potential quality assurance (QA) method is explored (including assessment of depth dose, dose linearity, dose rate linearity and beam profile) for clinical electron beams based on imaging Cerenkov light. The potential of using a standard commercial camera to image Cerenkov light generated from electrons in water for fast QA measurement of a clinical electron beam was explored and compared to ionization chamber measurements. The new method was found to be linear with dose and independent of dose rate (to within 3%). The uncorrected practical range measured in Cerenkov images was found to overestimate the actual value by 3 mm in the worst case. The field size measurements underestimated the dose at the edges by 5% without applying any correction factor. Still, the measured field size could be used to monitor relative changes in the beam profile. Finally, the beam-direction profile measurements were independent of the field size within 2%. A simulation was also performed of the deposited energy and of Cerenkov production in water using GEANT4. Monte Carlo simulation was used to predict the measured light distribution around the water phantom, to reproduce Cerenkov images and to find the relation between deposited energy and Cerenkov production. The camera was modelled as a pinhole camera in GEANT4, to attempt to reproduce Cerenkov images. Simulations of the deposited energy and the Cerenkov light production agreed with each other for a pencil beam of electrons, while for a realistic field size, Cerenkov production in the build-up region overestimated the dose by +8%.
T cell activation by a bispecific anti‐CD3/anti‐major histocompatibility complex class I antibody (1990)

A bispecific anti-CD3/anti-major histocompatibility complex (MHC) class I antibody (Ab) that is able to activate human T cells in the absence of a second signal has been used to compare activation by this Ab to signaling by anti-CD3 Ab or by antigen (Ag). We have studied early, intermediate and late events that occur after triggering of a tetanus toxoid-specific T cell clone. While bivalent anti-CD3 Ab induce transient (less than 20 min) intracellular Ca2+ concentration increases, the bispecific Ab, like antigen-presenting cells plus Ag, produces sustained (greater than 2 h) elevated intracellular Ca2+ concentration. In addition, while the anti-CD3 Ab only induces low levels of c-myc mRNA lasting less than 3 h, the bispecific Ab induces high levels which are maintained for at least 8 h after triggering. Late events, such as interleukin 2 receptor expression and proliferation, occurring more than 20 h after activation, were seen only when T cells were stimulated by bispecific Ab or by antigen-presenting cell and Ag. Cells activated by linking T cell receptor (TcR)/CD3 to MHC class I antigens could not be activated by cross-linking the MHC and TcR/CD3 structures separately. Therefore, we propose that the bispecific Ab functions by modifying the membrane dynamics of the TcR/CD3 complex, rather than by the generation of a second signal through class I antigens.
Bipolar switching in chalcogenide phase change memory (2016)

Phase change materials based on chalcogenides are key enabling technologies for optical storage, such as rewritable CD and DVD, and recently also electrical nonvolatile memory, named phase change memory (PCM). In a PCM, the amorphous or crystalline phase affects the material band structure, hence the device resistance. Although phase transformation is extremely fast and repeatable, the amorphous phase suffers structural relaxation and crystallization at relatively low temperatures, which may affect the temperature stability of PCM state. To improve the time/temperature stability of the PCM, novel operation modes of the device should be identified. Here, we present bipolar switching operation of PCM, which is interpreted by ion migration in the solid state induced by elevated temperature and electric field similar to the bipolar switching in metal oxides. The temperature stability of the high resistance state is demonstrated and explained based on the local depletion of chemical species from the electrode region.
A 280mV 3.1pJ/code Huffman Decoder for DEFLATE Decompression Featuring Opportunistic Code Skip and 3-way Symbol Generation in 14nm Tri-gate CMOS (2018)

A 10,790μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> dynamic Huffman decoder targeted for DEFLATE header decompression in area and energy constrained IoT platforms is fabricated in 14nm Trigate CMOS. Ternary CAM (TCAM) assisted concurrent literal-length and distance tree generation, opportunistic code-skipping with register file tagging to leverage symbol sparsity, and 3-way forward-reverse-parallel Huffman decoding results in 300 cycle header processing latency, 2.4× faster than conventional serial decoding approach. Absence of custom circuits enables a fully synthesizable design operating over a wide supply range of 210-900mV with 895M codes/s throughput measured at 750mV, 25°C. Near-threshold voltage operation and clock power reduction with vector latch insertion provides peak energy-efficiency of 3.1pJ/code (5.9× higher than nominal) at 280mV, 15MHz operation with 32μW and 6μW total and leakage power consumption.
Interception of an iminium ion equivalent by intramolecular nucleophilic attack by a silyl ether during lithium aluminium hydride reduction of a tertiary lactam (1991)

The efficient formation of a bicyclic oxazolidine by lithium aluminium hydride reduction of a tertiary amide provides an example of intramolecular nucleophilic capture of an iminium ion equivalent by the oxygen of a silyl ether.
Mass spectroscopy-defined neoepitopes are a rich source of tumor rejection-mediating neoepitopes in a mouse sarcoma (2019)

Abstract Using tandem mass spectroscopy (MS), we identified 3646 unique sequences among peptides eluted from purified Kd and Dd MHC I molecules of the BALB/c fibrosarcoma Meth A. These peptides were cross-referenced with the output of neoepitopes predicted for this tumor by our prediction pipeline CCCP (Cross Consensus Calling Platform). Eleven (11) of the eluted peptides were identified as neoepitopes and eight neoepitopes (of 11) were confirmed by targeted MS. Each neoepitope was used to immunize BALB/c mice (twice, one week apart, using precise neoepitopes along with bone marrow-derived dendritic cells); mice were challenged with Meth A cells one week after the last immunization, and tumor growth was monitored in individual mice. In parallel, immunized mice were tested for CD8+ T cells to the neoepitopes using tetramer staining and interferon g secretion by CD8 cells. Four of the eight neoepitopes elicited rejection of Meth A fibrosarcoma; two of the four neoepitopes elicited highly potent tumor rejection, while the other two elicited statistically significant but weaker tumor rejection. Of the two strong neoepitopes, only one elicited a measurable CD8 response. Both weak neoepitopes elicited measurable CD8 responses. Of the four neoepitopes that did not elicit tumor rejection, only one elicited a measurable CD8 response; this CD8 response was the strongest of all CD8 responses detected. These observations indicate that MS-defined neoepitopes can be a rich source of neoepitopes that can mediate tumor rejection. Further, they highlight the fact that CD8 responses are not a good predictive surrogates for tumor rejection.
A Fault Diagnosis and Prognosis Method for Lithium-Ion Batteries Based on a Nonlinear Autoregressive Exogenous Neural Network and Boxplot (2021)

The frequent occurrence of electric vehicle fire accidents reveals the safety hazards of batteries. When a battery fails, its symmetry is broken, which results in a rapid degradation of its safety performance and poses a great threat to electric vehicles. Therefore, accurate battery fault diagnoses and prognoses are the key to ensuring the safe and durable operation of electric vehicles. Thus, in this paper, we propose a new fault diagnosis and prognosis method for lithium-ion batteries based on a nonlinear autoregressive exogenous (NARX) neural network and boxplot for the first time. Firstly, experiments are conducted under different temperature conditions to guarantee the diversity of the data of lithium-ion batteries and then to ensure the accuracy of the fault diagnosis and prognosis at different working temperatures. Based on the collected voltage and current data, the NARX neural network is then used to accurately predict the future battery voltage. A boxplot is then used for the battery fault diagnosis and early warning based on the predicted voltage. Finally, the experimental results (in a new dataset) and a comparative study with a back propagation (BP) neural network not only validate the high precision, all-climate applicability, strong robustness and superiority of the proposed NARX model but also verify the fault diagnosis and early warning ability of the boxplot. In summary, the proposed fault diagnosis and prognosis approach is promising in real electric vehicle applications.
HXT5 expression is under control of STRE and HAP elements in the HXT5 promoter (2004)

Hexose transporter (Hxt) proteins transport glucose across the plasma membrane in the yeast Saccharomyces cerevisiae. Recently, we have shown that expression of HXT5 is regulated by the growth rate of the cells. Because gene expression is regulated by binding of specific transcription factors to regulatory elements in the promoters of genes, the presence of putative regulatory elements in the promoter of HXT5 was determined by computer-assisted analysis. This revealed the presence of two putative stress-responsive elements (STREs), one putative post-diauxic shift (PDS) element and two putative Hap2/3/4/5p (HAP) complex binding elements. The involvement of these elements was studied by using mutations in a HXT5 promoter-LacZ fusion construct. Growth during various conditions that result in low growth rates of yeast cells revealed that the STRE most proximal to the translation initiation site seemed to be involved in particular in regulation of HXT5 expression during growth at decreased growth rates. In addition, the HAP elements seemed to be required during growth on non-fermentable carbon sources. The PDS element and, to a lesser extent, the other STRE showed particular involvement in regulation of HXT5 expression during growth on ethanol. Finally, it was shown that the PKA pathway, which is known to be involved in expression of STRE-regulated genes, was also involved in regulation of HXT5 expression. A possible mechanism by which expression of HXT5 could be regulated by the transcriptional regulatory elements in the promoter is discussed.
Development of two-phase flow dynamic instabilities evaluation technique for sliding pressure once-through boilers (2021)

In order to improve the load following performance of ultra-super critical sliding pressure once-through boilers, evaporator tubes are required to operate under conditions different from those in the past. However, the conditions for occurrence of density wave oscillation in the multiple parallel tube structure used in the boiler was not clear. Therefore, verification tests were conducted in a condition equivalent to that of an actual boiler, and an evaluation method of flow stability was developed. The test was conducted using water as the working fluid in 4 parallel tubes with an inner diameter of 10 mm and a heating length of 7.4 m. The calculation results by developed evaluation method were in good agreement with the test results.
In‐Situ Processing of Nickel Aluminide Coatings on Steel Substrates (2001)

This chapter contains sections titled: Introduction Experimental Procedure Results and Discussion Summary Acknowledgments
Multispectral imaging for quality control of laboratory‐reared Anastrepha fraterculus (Diptera: Tephritidae) pupae (2019)

Abstract The sterile insect technique (SIT) has been widely used to suppress several fruit fly species. In southern Brazil, millions of sterile flies of the South American fruit fly, Anastrepha fraterculus Wiedemann (Dipetra: Tephritidae), will be produced in a mass‐rearing facility called MOSCASUL to suppress wild populations from commercial apple orchards. In spite of standard rearing conditions, the quality of pupal batches can be inconsistent due to various factors. The quantification of poor quality material (e.g. empty pupae, dead pupae or larvae) is necessary to track down rearing issues, and pupal samples must be taken randomly and evaluated individually. To speed up the inspection of pupal samples by replacing the manual testing with the mechanized one, this study assessed a multispectral imaging (MSI) system to distinguish the variations in quality of A. fraterculus pupae and to quantify the variations based on reflectance patterns. Image acquisition and analyses were performed by the VideometerLab4 system on 7‐d‐old pupae by using 19 wavelengths ranging from 375 to 970 nm. The image representing the near infrared wavelength of 880 nm clearly distinguished among high‐quality pupae and the other four classes (i.e. low‐quality pupae, empty pupae, dead pupae and larvae). The blind validation test indicated that the MSI system can classify the fruit fly pupae with high accuracy. Therefore, MSI‐based classification of A. fraterculus pupae can be used for future pupal quality assessments of fruit flies in mass‐rearing facilities.