gebhart/patrepeval huggingface dataset:
Mapping Resection Progress by Tool-Tip Tracking during Brain Tumor Surgery for Real-Time Estimation of Residual Tumor (2023)

Surgical resection continues to be the primary initial therapeutic strategy in the treatment of patients with brain tumors. Computerized cranial neuronavigation based on preoperative imaging offers precision guidance during craniotomy and early tumor resection but progressively loses validity with brain shift. Intraoperative MRI (iMRI) and intraoperative ultrasound (iUS) can update the imaging used for guidance and navigation but are limited in terms of temporal and spatial resolution, respectively. We present a system that uses time-stamped tool-tip positions of surgical instruments to generate a map of resection progress with high spatial and temporal accuracy. We evaluate this system and present results from 80 cranial tumor resections. Regions of the preoperative tumor segmentation that are covered by the resection map (True Positive Tracking) and regions of the preoperative tumor segmentation not covered by the resection map (True Negative Tracking) are determined for each case. We compare True Negative Tracking, which estimates the residual tumor, with the actual residual tumor identified using iMRI. We discuss factors that can cause False Positive Tracking and False Negative Tracking, which underestimate and overestimate the residual tumor, respectively. Our method provides good estimates of the residual tumor when there is minimal brain shift, and line-of-sight is maintained. When these conditions are not met, surgeons report that it is still useful for identifying regions of potential residual.
AppCloak: Rapid Migration of Legacy Applications into Cloud (2014)

Although cloud has been adopted by many organizations as their main infrastructure for IT delivery, there are still a large number of legacy applications running in non-cloud hosting environments. Thus, it is crucial to have migration techniques for such legacy applications so that they can benefit from many advantages of cloud such as elasticity, low upfront investment, and fast time-to-market. However, migrating large number of legacy applications into cloud in a timely manner is a daunting task. Common techniques such as redeveloping (i.e., modernizing) them or reinstalling from the scratch entails high costs. To mitigate these problems, we have developed a rapid migration technique, called AppCloak, that allows users to literally copy an already-installed application to cloud and run it without any modifications. The technique is based on intercepting a selected set of system calls and replacing the parameters and return values to hide any differences of environments to the application. We demonstrate that our technique works in Amazon EC2 and quantify the performance overhead.
Enhanced Cycling Stability of Hybrid Li–Air Batteries Enabled by Ordered Pd3Fe Intermetallic Electrocatalyst (2015)

We report an ordered Pd3Fe intermetallic catalyst that exhibits significantly enhanced activity and durability for the oxygen reduction reaction under alkaline conditions. Ordered Pd3Fe enables a hybrid Li-air battery to exhibit the best reported full-cell cycling performance (220 cycles, 880 h).
Multidrug Resistance of DNA-Mediated Transformants is Linked to Transfer of the Human mdr1 Gene (1986)

Mouse NIH 3T3 cells were transformed to multidrug resistance with high-molecular-weight DNA from multidrug-resistant human KB carcinoma cells. The patterns of cross resistance to colchicine, vinblastine, and doxorubicin hydrochloride (Adriamycin; Adria Laboratories Inc.) of the human donor cell line and mouse recipients were similar. The multidrug-resistant human donor cell line contains amplified sequences of the mdr1 gene which are expressed at high levels. Both primary and secondary NIH 3T3 transformants contained and expressed these amplified human mdr1 sequences. Amplification and expression of the human mdr1 sequences and amplification of cotransferred human Alu sequences in the mouse cells correlated with the degree of multidrug resistance. These data suggest that the mdr1 gene is likely to be responsible for multidrug resistance in cultured cells.
Hybrid paging and location tracking scheme for inactive 5G UEs (2017)

User Equipment (UE) paging and location tracking are influenced by the underling state handling model. There are recent proposals to introduce a new RRC state called RRC Inactive as a main state for inactive UEs in 5 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sup> Generation (5G) cellular systems. One of the characteristics of the new state is that the interface between the Radio Access Network (RAN) and Core Network (CN) is kept. Considering this characteristic, there are proposals for a RAN controlled paging and location tracking schemes for RRC Inactive UEs. In this paper, we show that this approach is not always beneficial, especially for high mobility UEs. Instead, we propose a hybrid paging and location tracking scheme where both RAN and CN are involved in the paging and location tracking of RRC Inactive UEs. This is done transparently to the UE. We further propose a hierarchical paging and location tracking scheme to reduce the signaling overhead from paging and location tracking updates. The scheme is applicable to both RAN based and CN based paging and location tracking schemes.
Differential Inhibition of Type I Interferon Induction by Arenavirus Nucleoproteins (2007)

We have documented that the nucleoprotein (NP) of the prototypic arenavirus lymphocytic choriomeningitis virus is an antagonist of the type I interferon response. In this study we tested the ability of NPs encoded by representative arenavirus species from both Old World and New World antigenic groups to inhibit production of interferon. We found that, with the exception of Tacaribe virus (TCRV), all NPs tested inhibited activation of beta interferon and interferon regulatory factor 3 (IRF-3)-dependent promoters, as well as the nuclear translocation of IRF-3. Consistent with this observation, TCRV-infected cells also failed to inhibit interferon production.
Multicast routing with mutual information accumulation (2014)

In this paper, we investigate the problem of multicast routing in networks using mutual information accumulation at the physical layer. In these networks, the minimum delay routing problem can be split into two subproblems: a) path selection, which is NP-complete, and b) resource allocation, which can be formulated as a linear program. We propose a simple, yet effective heuristic for path selection where we suggest that nodes are arranged, initially, in the order in which they decode a broadcast from the source. We compare the performance of this heuristic with other Steiner tree based heuristics for path selection using simulations and conclude that they exhibit similar delay performance. Additionally, good inner and outer bounds for multicast delay are derived and simulations show that our heuristic algorithms satisfy these bounds.
ChemInform Abstract: Rhodium‐Catalyzed Oxidative Coupling of Triarylmethanols with Internal Alkynes via Successive C—H and C—C Bond Cleavages. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
CNDesc: Cross Normalization for Local Descriptors Learning (2022)

For a long time, the local descriptors learning benefited from the use of L2 normalization, which projects the descriptor space onto the hypersphere. However, there is no free lunch in the world. Although hypersphere description space stabilizes the optimization and improves the repeatability of the descriptors, it causes the descriptors to have a denser distribution, which reduces the discrimination between descriptors and leads to some incorrect matches. To alleviate this problem, we propose the learnable <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">cross normalization</i> technology as an alternative to L2 normalization, which can achieve a consistent improvement in several of the current popular local descriptors. In addition, we propose an ER-Backbone that can efficiently reuse features in descriptors extraction and an IDC Loss that can provide an image-level description space distribution consistency constraint to further stimulate the performance of the local descriptors. Based on the above innovations, we provide a novel local descriptors extraction method named CNDesc. We perform experiments on image matching, homography estimation, 3D reconstruction, and visual localization tasks, and the results demonstrate that our CNDesc surpasses the current state-of-the-art local descriptors. Our code is available at <uri xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">https://github.com/vignywang/CNDesc</uri> .
A plant-expressed conjugate vaccine breaks CD4+ tolerance and induces potent immunity against metastatic Her2+ breast cancer (2016)

Passive antibody therapy for cancer is an effective but costly treatment modality. Induction of therapeutically potent anticancer antibodies by active vaccination is an attractive alternative but has proven challenging in cancer due to tolerogenic pressure in patients. Here, we used the clinically relevant cancer target Her2, known to be susceptible to targeting by antibody therapy, to demonstrate how potent antibody can be induced by vaccination. A novel 44kD Her2 protein fragment was generated and found to be highly effective at inducing anti-Her2 antibody including trastuzumab-like reactivities. In the tolerant and spontaneous BALB-neuT mouse model of metastatic breast cancer this Her2-targeting vaccine was only effective if the fragment was conjugated to a foreign immunogenic carrier; Fragment C of tetanus toxin. Only the conjugate vaccine induced high affinity anti-Her2 antibody of multiple isotypes and suppressed tumor development. The magnitude of CD4(+) T-cell help and breadth of cytokines secreted by the CD4(+) T helper (Th) cells induced to the foreign antigen was critical. We used a highly efficient plant-based bio-manufacturing process for protein antigens, magnICON, for vaccine expression, to underpin feasibility of future clinical testing. Hence, our novel Her2-targeting conjugate vaccine combines preclinical efficacy with clinical deliverability, thus setting the scene for therapeutic testing.
Kinetics of drug release from electrospun poly([epsilon]-caprolactone) (2005)

Electrospinning is a procedure used to produce submicron, fibrous polymeric mats. Interest in electrospinning for many biomedical applications, such as tissue engineering and drug delivery, is growing due to the ability to control fiber diameter and morphology with simple equipment. The objective of this paper was to study the kinetics of drug release from porous electrospun poly(-caprolactone) (PCL) and compare it to the release from dense cast films. Fibers and cast films were produced from 13 wt% PCL in tetrahydrofuran (THF). Prior to electrospinning or casting, appropriate amounts of alizarin red or acetaminophen were incorporated into the polymer solution. The release of these two compounds was studied to determine the correlation between the effective diffusion coefficient and the size of the molecule. The morphology of the electrospun samples was characterized by scanning electron microscopy. The in vitro release of alizarin red or acetaminophen from the drug delivery systems were measured by UV-VIS spectroscopy. An increased loading of alizarin red or acetaminophen led to greater average fiber diameters. Diffusion was determined to be the dominant mode of mass transfer because the release of both alizarin red and acetaminophen was linear when plotted against the square root of time. Based on Fick's Second Law of Diffusion and the appropriate boundary conditions from our experimental set up, a mathematical model was used to calculate the effective diffusion coefficients. Effective diffusion coefficients of alizarin red through PCL films and electrospun samples were calculated to be 2.3 x 10-14 m2/s and 2.4 x 10-12 m2/s, respectively. Diffusion coefficients for acetaminophen through PCL films and electrospun samples were calculated to be 5.8 x 10-14 m2/s and 1.6 x 10-11 m2/s, respectively. These diffusion coefficients are in agreement with those reported in the 2 literature under similar conditions. Release of alizarin red from electrospun samples was over 100 times faster than from dense films while release of acetaminophen was over 270 times faster out of electrospun samples than the dense films. Release out of the electrospun samples was dominated by diffusion through the pores. The release from electrospun mats can be controlled by altering the fiber diameter and pore size. Electrospun drug delivery systems could have applications where rapid, controlled release is desired.
Depth of interaction effect on timing resolution in PET block detectors (2005)

We have investigated the effect of the depth of interaction (DOI) on the coincidence timing distribution of a PET block detector excited with 511 keV photons. Measurements were performed with a detector consisting of a quad photomultiplier tube (PMT) optically coupled to a 6×6 array of mixed lutetium silicate (MLS) scintillator crystals with different surface treatments. The PET detector was side-illuminated with an electronically collimated beam and the coincidence timing distribution was recorded at different DOI as the detector block was stepped through the beam. The shift of the timing distribution peak measured the variation of the average propagation time of the scintillation photons within the block. From top to bottom (30 mm distance), the average delay ranged from 120 ps for polished crystals up to 350 ps for crystals with all sides roughened. The results of this study allowed modeling the effect of DOI delay on timing performance for front-end irradiation with 511 keV photons, assuming a range of different values for the intrinsic timing resolution of the detector. The relative contribution from DOI effects to the total time coincidence resolution was found to be significant only for detectors with an intrinsic time resolution less than 250 ps FWHM.
Pheromones, binding proteins and receptor responses in rodents (2003)

Their well-developed chemical communication systems make rodents popular in research that aims to understand the connections between genes, hormones and behaviour. Structural identification of several pheromones in mice, rats and hamsters now makes it feasible to employ their synthetic analogues in probing olfactory neurons and in the study of various pheromone-protein interactions in intimate detail.
Re: Shrinkage of Experimental Benign Prostatic Hyperplasia and Reduction of Prostatic Cell Volume by a Gastrin-Releasing Peptide Antagonist (2013)

No AccessJournal of UrologyInvestigative Urology1 Oct 2013Re: Shrinkage of Experimental Benign Prostatic Hyperplasia and Reduction of Prostatic Cell Volume by a Gastrin-Releasing Peptide Antagonist Anthony AtalaM.D. Anthony AtalaAnthony Atala More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.06.055AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Re: Shrinkage of Experimental Benign Prostatic Hyperplasia and Reduction of Prostatic Cell Volume by a Gastrin-Releasing Peptide Antagonist." The Journal of Urology, 190(4), pp. 1436–1437 © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 190Issue 4October 2013Page: 1436-1437Supplementary Materials Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.Metrics Author Information Anthony Atala More articles by this author Expand All Advertisement PDF downloadLoading ...
A Wireless Metamaterial-Inspired Passive Rotation Sensor With Submilliradian Resolution (2018)

A novel passive wireless rotation sensing system with high levels of sensitivity and resolution is proposed and demonstrated for measuring elastic-region bending in materials such as steel. This system is composed of a transceiver antenna and a double-plate sensor in the form of an inter-digital configuration, which does not incorporate any active component. The sensor exhibits a large rotation resolution of 20 μ-rad, an excellent sensitivity of 28 MHz/° in average, and a large linear dynamic range of approximately 40°. In operation, as a result of the relative rotation between the plates of the sensor, the operating resonance frequency of the system is shifted. This is read out and tracked in the S <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">11</sub> response of the transceiver antenna from which the rotation angle is determined. The prototype is designed for microwave regime and it is suitable for measuring very small angles (10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-4</sup> ~ 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-5</sup> rad). Critical figuresof-merit of the sensor including sensitivity, dynamic range, and resolution are assessed via systematic measurements, and the validity of resolution experiment is verified by employing digital image correlation method for 2-D measurements.
Hexa-X: Trustworthy Networking Beyond 5G (2021)

Trustworthiness is one of the six main research challenges the HEXA-X project is committed to address to set the foundations of 6G networks. Security forms a basic foundation for all systematization of trust in connectivity, and security considerations must encompass all aspects of cybersecurity: resilience against attacks, preservation of privacy, and ethical, safe application of automation to network operations and applications. Security also depends on active management of threat surfaces, including proactive measures such as threat prevention and protection as well as reactive measures such as attack discovery and mitigation. As network services consolidate as essential components in a growing number of application scenarios, their dependability and, equally important, the perception of such dependability as an achievable characteristic, becomes a key feature for network operators, service providers, application developers and, above all, end users. A realistic approach to this trustworthiness challenge must acknowledge that complete security is not achievable, and that all security measures comes with a cost inTrustworthiness is one of the six main research challenges the HEXA-X project is committed to address to set the foundations of 6G networks. Security forms a basic foundation for all systematization of trust in connectivity, and security considerations must encompass all aspects of cybersecurity: resilience against attacks, preservation of privacy, and ethical, safe application of automation to network operations and applications. Security also depends on active management of threat surfaces, including proactive measures such as threat prevention and protection as well as reactive measures such as attack discovery and mitigation. As network services consolidate as essential components in a growing number of application scenarios, their dependability and, equally important, the perception of such dependability as an achievable characteristic, becomes a key feature for network operators, service providers, application developers and, above all, end users. A realistic approach to this trustworthiness challenge must acknowledge that complete security is not achievable, and that all security measures comes with a cost in other terms (such as usability, agility, or swiftness). Therefore, a balance is required in terms of this cost, the risks to be considered, and the impact of a security breach on the mission objectives being served. other terms (such as usability, agility, or swiftness). Therefore, a balance is required in terms of this cost, the risks to be considered, and the impact of a security breach on the mission objectives being served.
Williams-Beuren Syndrome Diagnosis Using Fluorescence <i>In Situ</i> Hybridization (2006)

Williams-Beuren syndrome (WBS) is most commonly caused by a 1.5-Mb hemizygous deletion of chromosome 7q 11.23. Other genomic rearrangements of this region have also been described, some as polymorphisms and others as rare variants, the latter often being directly associated with clinical symptoms. Fluorescence in situ hybridization of either metaphase or interphase nuclei can be used to detect all of these chromosomal rearrangements, providing the ability to test this segment of chromosome 7 in families with a suspected diagnosis of WBS.
A Novel and Automated Circle Pattern Recognition Technique for Infra-Red Stereo Camera Calibration (2013)

Autonomous robots are increasingly used to respond to disaster scenarios. Sensor systems for those robots must deliver reliable 3D information for both day and night operation. Infra-red stereo camera systems are often used to deliver 3D information 24/7. However, reliable calibration of a 3D stereo sensor is both difficult and crucial. This paper presents a novel method to reliably extract circle-like shapes from infra-red images of specific calibration patterns. Based on these circle positions the calibration of an infra-red stereo vision sensor system can be achieved. Experimental evaluations of our approach show that our automated method is both robust and reliable.
Extended local Rytov Fourier migration method (1999)

Abstract We develop a novel depth-migration method termed the extended local Rytov Fourier (ELRF) migration method. It is based on the scalar wave equation and a local application of the Rytov approximation within each extrapolation interval. Wavefields are Fourier transformed back and forth between the frequency-space and frequency-wavenumber domains during wavefield extrapolation. The lateral slowness variations are taken into account in the frequency-space domain. The method is efficient due to the use of a fast Fourier transform algorithm. Under the small angle approximation, the ELRF method leads to the split-step Fourier (SSF) method that is unconditionally stable. The ELRF method and the extended local Born Fourier (ELBF) method that we previously developed can handle wider propagation angles than the SSF method only account for the phase and amplitude changes due to the lateral variations of slowness, whereas the SSF method only accounts for the phase changes. The stability of the ELRF method is controlled more easily than that of the ELBF method.
Molecular Dynamics Simulations of plasma sputtering deposition and nanocluster growth on surface. (2013)

Comm. Orale
Continuous Tenecteplase Infusion Combined With Peri/Postprocedural Platelet Glycoprotein IIb/IIIa Inhibition in Peripheral Arterial Thrombolysis:Initial Safety and Feasibility Experience (2004)

Continuous TNK infusion (0.25-0.50 mg/h) is a safe and feasible treatment for continuous pharmacological thrombolysis in ALI, potentially offering decreased infusion times and bleeding complications, as well as improved outcomes.