gebhart/patrepeval huggingface dataset:
Adiponectin Accumulation in the Tetinal Vascular Endothelium and its Possible Role in Preventing Early Diabetic Microvascular Damage (2021)

Abstract Adiponectin (APN), a protein abundantly secreted from adipocytes, has been reported to possess beneficial effects on cardiovascular diseases in association with its accumulation on target organs and cells by binding to T-cadherin. However, little is known about the role of APN in the development of diabetic microvascular complications, such as diabetic retinopathy (DR). Here we investigated the impact of APN on the progression of early retinal vascular damage using a streptozotocin (STZ)-induced diabetic mouse model. Our immunofluorescence results clearly showed T-cadherin-dependent localization of APN in the vascular endothelium of retinal arterioles, which was progressively decreased during the course of diabetes. Such reduction of retinal APN accompanied the early features of DR, represented by increased vascular permeability, and was prevented by glucose-lowering therapy with dapagliflozin, a selective sodium-glucose co-transporter 2 inhibitor. In addition, APN deficiency resulted in severe vascular permeability under relatively short-term hyperglycemia, together with a significant increase in vascular cellular adhesion molecule-1 (VCAM-1) and a reduction in claudin-5 in the retinal endothelium. The present study demonstrated a possible protective role of APN against the development of DR.
Decorating the Surface of Escherichia Coli with Bacterial Lipoproteins: A Comparative Analysis of Different Display Systems (2020)

Abstract Background: The display of recombinant proteins on cell surfaces has a plethora of applications including vaccine development, screening of peptide libraries, whole-cell biocatalysts and biosensor development for diagnostic, industrial or environmental purposes. In the last decades, a wide variety of surface display systems have been developed for the exposure of recombinant proteins on the surface of Escherichia coli , such as autotransporters and outer membrane proteins. Results: In this study, we assess three approaches for the surface display of a panel of heterologous and homologous mature lipoproteins in E. coli : four from Neisseria meningitidis and four from the host strain that are known to be localised in the inner leaflet of the outer membrane. Constructs were made carrying the sequences coding for eight mature lipoproteins, each fused to the delivery portion of three different systems: the autotransporter adhesin involved in diffuse adherence-I (AIDA-I) from enteropathogenic E. coli , the Lpp’OmpA chimaera and a truncated form of the ice nucleation protein (INP), InaK-NC (N-terminal domain fused with C-terminal one) from Pseudomonas syringae. In contrast to what was observed for the INP constructs, when fused to the AIDA-I or Lpp’OmpA, most of the mature lipoproteins were displayed on the bacterial surface both at 37°C and 25°C as demonstrated by FACS analysis, confocal and transmission electron microscopy. Conclusions: To our knowledge this is the first study that compares surface display systems using a number of passenger proteins. We have shown that the experimental conditions, including the choice of the carrier protein and the growth temperature, play an important role in the translocation of mature lipoproteins onto the bacterial surface . Despite all the optimization steps performed with the InaK-NC anchor motif, surface exposure of the passenger proteins used in this study was not achieved. For our experimental conditions, Lpp’OmpA chimaera has proved to be an efficient surface display system for the homologous passenger proteins although cell lysis and phenotype heterogeneity were observed. Finally, , AIDA-I was found to be the best surface display system for mature lipoproteins (especially heterologous ones) in the E. coli host strain with no inhibition of growth and only limited phenotype heterogeneity.
Physician Experiences and Understanding of Genomic Sequencing in Oncology (2017)

The amount of information produced by genomic sequencing is vast, technically complicated, and can be difficult to interpret. Appropriately tailoring genomic information for non-geneticists is an essential next step in the clinical use of genomic sequencing. To initiate development of a framework for genomic results communication, we conducted eighteen qualitative interviews with oncologists who had referred adult cancer patients to a matched tumor-normal tissue genomic sequencing study. In our qualitative analysis, we found varied levels of clinician knowledge relating to sequencing technology, the scope of the tumor genomic sequencing study, and incidental germline findings. Clinicians expressed a perceived need for more genetics education. Additionally, they had a variety of suggestions for improving results reports and possible resources to aid in results interpretation. Most clinicians felt genetic counselors were needed when incidental germline findings were identified. Our research suggests that more consistent genetics education is imperative in ensuring the proper utilization of genomic sequencing in cancer care. Clinician suggestions for results interpretation resources and results report modifications could be used to improve communication. Clinicians' perceived need to involve genetic counselors when incidental germline findings were found suggests genetic specialists could play a critical role in ensuring patients receive appropriate follow-up.
[Comparative study of 2 culture methods by seeding, in hemoculture bottles, the dialysis fluid from patients in continuous ambulatory peritoneal dialysis]. (1995)

Both methods were similar and the more important factor to increase the yield of culture is to remove the antibiotic presents in centrifuged fluid.
Transport Layer Security (TLS) Authorization Using KeyNote (2010)

This document specifies the use of the KeyNote trust-management system
as an authorization extension in the Transport Layer Security (TLS)
Handshake Protocol, according to [AUTHZ]. Extensions carried in the
client and server hello messages confirm that both parties support the
desired authorization data types. Then, if supported by both the
client and the server, KeyNote credentials are exchanged during the
supplemental data handshake message.
Hyperacute renal failure as the initial presentation of systemic lupus erythematosus (2005)

SLE nephritis is usually a slow process that may lead to renal failure many years after its first presentation. Success of different therapeutic modalities in preventing renal failure is therefore evaluated and compared only after many years of treatment. Lately, this conservative philosophy has been challenged with the acknowledgment of collapsing glomerulopathy (CG), a recent recognized clinical-pathological entity, characterized by rapidly progressive renal failure. Despite this ominous description we present an unusual case of a patient who presented with systemic lupus erythematosus (SLE) and clinical and pathological findings of CG, who completely remitted several weeks after commencing immunosuppressive therapy with intravenous cyclophosphamide and prednisolone.
XTAG system (1994)

This paper present the XTAG system, a grammar development tool based on the Tree Adjoining Grammar (TAG) formalism that includes a wide-coverage syntactic grammar for English. The various components of the system are discussed and preliminary evaluation results from the parsing of various corpora are given. Results from the comparison of XTAG against the IBM statistical parser and the Alvey Natural Language Tool parser are also given.
Smart cameras: 2D affine models for determining subject facial expressions (2010)

In this paper we consider how next generation of smart cameras will move beyond face detection and tracking to develop more useful analysis tools for determining the expressions and emotions of the subjects in images. An initial proof-of-concept using an extension of an Active Appearance Model (AAM) to measure facial parameters and a set of classifiers to determine facial states are described. Preliminary findings are encouraging and suggest that the use of the component-based AAM models and SVM classifiers will enable new applications and opportunities in smart cameras.
NMR investigation of lipophilic cage ligands 2—Structural assignments and conformational properties of the ligand 12‐hexadecyl ‐7,17,22,27‐tetraoxa‐1,4,10,14‐tetraazatricyclo[12.5.5.54,10] ‐nonacosane and of its sodium, potassium and silver complexes (1987)

Abstract Two‐dimensional homonuclear (COSY, phase‐sensitive double quantum filtered COSY) and heteronuclear shift correlated experiments were employed to characterize fully the cylindrical cage ligand 12‐hexadecyl‐7,17,22,27‐tetraoxa‐1,4,10,14‐tetraazatricyclo[12.5.5.5 4,10 ] nonacosane (1) and its sodium, potassium and silver complexes. 13 C NMR variable temperature experiments indicated that the free ligand 1 is a mobile molecule in a fast conformational equilibrium at room temperature, whereas its sodium complex is more rigid, some degrees of freedom being allowed in that part of the molecule featuring the longest bridge. The potassium derivative behaves similarly to its sodium counterpart. For the silver complex the differences observed have been attributed to a stronger interaction of the metal ion with nitrogen atoms.
Suyla İğnelenmiş Dokunmamış Kumaşlarda Yüzey Görünümünün Gelişimi (2003)

Kisa bir sure once es-olusum(co-occurrence) temeline dayanan bir gorunum analiz metoduyla ilgili bir makalemizi sunduk. Bu makalemizde de ayni gorunum analiz metodunu kullanilarak, suyla ignelenmis (dolastirilmis) dokunmamis kumaslardaki yuzey gorunumunun islem parametrelerine bagli olarak gelisimini inceleyecegiz. Gorunumdeki degisimi suyla igneleme enerjisiyle iliskilendirerek verilerimizi degerlendirecegiz. Islem enerjisi, makinadaki basinc degisimi ve gecis sayisina gore kontrol edilmis, tum kumaslar ayni tul ve ayni destek bandi uzerinde uretilmistir. Verilerimiz bize, yuzey belirginliginin basinc ile dogru orantili olarak belli bir degere kadar iyilestigini ve daha sonra ise gorunumun bozuldugunu gostermistir. Anahtar Kelimeler: Gorunum analizi, suyla igneleme(dolastirma), spesifik enerji, es-olusum yontemi.
Toward Scalable Social Alt Text: Conversational Crowdsourcing as a Tool for Refining Vision-to-Language Technology for the Blind (2017)

The access of visually impaired users to imagery in social media is constrained by the availability of suitable alt text. It is unknown how imperfections in emerging tools for automatic caption generation may help or hinder blind users' understanding of social media posts with embedded imagery. In this paper, we study how crowdsourcing can be used both for evaluating the value provided by existing automated approaches and for enabling workflows that provide scalable and useful alt text to blind users. Using real-time crowdsourcing, we designed experiences that varied the depth of interaction of the crowd in assisting visually impaired users at caption interpretation, and measured trade-offs in effectiveness, scalability, and reusability. We show that the shortcomings of existing AI image captioning systems frequently hinder a user's understanding of an image they cannot see to a degree that even clarifying conversations with sighted assistants cannot correct. Our detailed analysis of the set of clarifying conversations collected from our studies led to the design of experiences that can effectively assist users in a scalable way without the need for real-time interaction. They also provide lessons and guidelines that human captioners and the designers of future iterations of AI captioning systems can use to improve labeling of social media imagery for blind users.
SiN-on-LiNbO3 Integrated Optical Modulation at Visible (2017)

Waveguides formed with SiN ridges on thin-film LiNbO3 enable a platform for compact integrated electro-optic devices in the visible and infrared. We demonstrate Mach-Zehnder modulators at λ = 674 nm with VπL products &lt; 0.5 V · cm, as well as ring resonators with Qs up to 340,000 at λ = 1590 nm.
Towards a 30kW/liter, Three-Phase Unity Power Factor Rectifier (2008)

In this paper, a forced air-cooled, 400kHz, 10kW Vienna Rectifier with a power density of 8.5kW/liter is presented. To further improve the power density, the switching frequency is increased to reduce the EMI filter volume. A design for an 18.5kW/liter, 2.5MHz rectifier is proposed. By using today's technology, it is calculated that the maximum power density for a forced air-cooled and water-cooled rectifier is 20.8kW/liter and 24kW/liter respectively. To achieve 30kW/liter, improvements must be made in passive component material properties, reducing semiconductor losses and improving the cooling system.
Stimulated Grain Refinement in Ni-Fe Alloy by Coarse Particles during Warm Multi-Directional Forging (2007)

A Ni-30 mass% Fe alloy with dispersed coarse oxide particles, ranging from 1 to 3 μm in diameter, was multi-directionally forged (MDF) at temperatures between 773 K and 873 K at a true strain rate of 1 x 10-3 s-1 in vacuum. For comparison, a particle-free Ni-Fe alloy was also prepared and MDFed. At 873 K, an obvious flow softening occurred during MDF especially in the alloy with dispersed particles, while work hardening followed by steady-state flow appeared at 773 K in both alloys. With increasing cumulative strain, the average grain size became gradually finer. However, the evolved microstructure was quite different depending on temperature and dispersion of particles. At 873 K, in the alloy with particles, equi-axed fine grains of about 1.3 μm in average was uniformly evolved at a cumulative strain of Σε = 2.4, while at 773 K the microstructure was still inhomogeneous. The above experimental results suggest important role of coarse particles to stimulate grain refinement.
Intravitreal HDAC Inhibitor Belinostat Effectively Eradicates Vitreous Seeds Without Retinal Toxicity In Vivo in a Rabbit Retinoblastoma Model (2021)

Molecularly targeted inhibition of HDACs with intravitreal belinostat was equally effective as standard-of-care melphalan but without retinal toxicity. Belinostat may therefore be an attractive agent to pursue clinically for intravitreal treatment of retinoblastoma.
A Versatile, Modular Platform for Multivalent Peptide Ligands Based on a Dendritic Wedge (2009)

Abstract A general methodology for the synthesis of multifunctional AB 2 , AB 3 , AB 4 , and AB 5 dendritic wedges is described based on an orthogonal protection strategy. Asymmetric polyamide dendrons that possess N‐terminal cysteine residues at the periphery were quantitatively functionalized with C‐terminal thioester peptides using native chemical ligation. Conjugation of biologically relevant groups at the focal point resulted in a series of related structures with a highly controlled valency (2–5) that can directly be used in a systematic study on the strength of multivalent interactions. Using our modular approach various ligands, functional groups and spacers can readily be combined in order to generate a toolbox for the development of smart biomaterials used in molecular medicine and imaging.
Recombination rate analysis in long minority carrier lifetime mid-wave infrared InGaAs/InAsSb superlattices (2021)

Gallium is incorporated into the strain-balanced In(Ga)As/InAsSb superlattice system to achieve the same mid-wave infrared cutoff tunability as conventional Ga-free InAs/InAsSb type-II superlattices, but with an additional degree of design freedom to enable optimization of absorption and transport properties. Time-resolved photoluminescence measurements of InGaAs/InAsSb superlattice characterization- and doped device structures are reported from 77 to 300 K and compared to InAs/InAsSb. The low-injection photoluminescence decay yields the minority carrier lifetime, which is analyzed with a recombination rate model, enabling the determination of the temperature-dependent Shockley–Read–Hall, radiative, and Auger recombination lifetimes and extraction of defect energy levels and capture cross section defect concentration products. The Shockley–Read–Hall-limited lifetime of undoped InGaAs/InAsSb is marginally reduced from 2.3 to 1.4 μs due to the inclusion of Ga; however, given that Ga improves the vertical hole mobility by a factor of &amp;gt;10×, a diffusion-limited InGaAs/InAsSb superlattice nBn could expect a lower bound of 2.5× improvement in diffusion length with significant impact on photodetector quantum efficiency and radiation hardness. At temperatures below 120 K, the doped device structures are Shockley–Read–Hall limited at 0.5 μs, which shows promise for detector applications.
Waste Face Surgical Mask Transformation into Crude Oil and Nanostructured Electrocatalysts for Fuel Cells and Electrolyzers (2021)

A novel route for the valorization of waste into valuable products was developed. Surgical masks commonly used for COVID 19 protection by stopping aerosol and droplets have been widely used, and their disposal is critical and often not properly pursued. This work intended to transform surgical masks into platinum group metal-free electrocatalysts for oxygen reduction reaction (ORR) and hydrogen evolution reaction (HER) as well as into crude oil. Surgical masks were subjected to controlled-temperature and -atmosphere pyrolysis, and the produced char was then converted into electrocatalysts by functionalizing it with metal phthalocyanine of interest. The electrocatalytic performance characterization towards ORR and HER was carried out highlighting promising activity. At different temperatures, condensable oil fractions were acquired and thoroughly analyzed. Transformation of waste surgical masks into electrocatalysts and crude oil can open new routes for the conversion of waste into valuable products within the core of the circular economy.
THE EFFECT OF FEEDING AND STARVATION UPON IMMUNOREACTIVE GLUCAGON IN THE PANCREATECTOMIZED PIG (1978)

The response of 13 pigs to total pancreatectomy was compared with the response of 9 animals to sham operation. Approximately half of each group had free access to food while the remainder received oral water only. Completeness of pancreatectomy was confirmed at autopsy, and the the disappearance of insulin and the rise in blood glucose to 14–19 mmol/1. Immunoreactive glucagon (IRG) increased in fed pancreatectomized pigs from the 3rd day postoperatively to a level of 350–400% of basal values by the 8th day. There was no rise in starved pancreatectomized animals, or in either group of sham-operated animals. The rises in glucose, free fatty acids, triglycerides and ketones were similar in the two groups of pigs.
Improving Short-Circuit Current of Concentrator Solar Cells Using a Deposited Microbead Layer (2020)

International audience
Thermosetting Polyetherimides: The Influence of Reactive Endgroup Type and Oligomer Molecular Weight on Synthesis, Network Formation, Adhesion Strength and Thermal Properties (1999)

Abstract The influence of the reactive endgroup on the synthesis, cure behavior and network properties of thermosetting polyetherimides was investigated. Reactive phenylethynyl, ethynyl and maleimide terminated etherimide oligomers were prepared and characterized. Optimal reaction conditions were established to produce fully endcapped oligomers with imidized structures and controlled molecular weight. The phenylethynyl and ethynyl endcapped systems were synthesized by ester-acid methods. The maleimide endcapped system utilized an amic-acid route. Phenylethynyl endcapped oligomers had good processibility and were thermally cured at high temperatures (350–380°C). The networks exhibited good thermal and hydrolytic stability and good adhesion strength, and are candidates for “primary'' bonding adhesives. In contrast, more reactive ethynyl and maleimide endcapped systems were prepared as “secondary'' bonding materials, which could be cured at temperatures lower than that of the T g of the primary structure. Lap shear test results obtained from NMP-cast/methanol-extracted scrim-cloth-supported precursors confirmed that good adhesion to titanium at both room temperature and at 177°C was achieved when cured at 250°C-280°C. High glass transition temperatures and good thermal stability were achieved as determined by thermal analysis (DSC, TGA and DMA). Solvent extraction measurements confirmed that very high gel fractions were obtained, which is consistent with good chemical resistance. The influence of molecular weight between crosslinks (Mc) on thermal and mechanical behavior was also investigated for 2,3,5,7 and 10k initial M n values. Lower molecular weight oligomers exhibited lower T g and cure temperatures, but higher cured network crosslink densities afforded higher T g and higher gel fractions, but with reduced toughness. Key Words: Thermosetting polyimidesend capsphenylethynylethynylmaleimidestructural adhesivescrosslink density
Abstract P171: Ligand-displaying-exosomes using RNA nanotechnology for targeted delivery of multispecific drugs for liver cancer regression (2021)

Abstract Liver cancer such as hepatocellular carcinoma (HCC) poorly responds to chemotherapeutics as there are no effective means to deliver drugs to liver cancer due to the intrinsic drug effluxion and detoxification properties of the liver. Exosomes are extracellular vesicles that deliver payload via a fusion mechanism to cell cytosol without endosome trapping. Here we report the use of GalNAc as ligands to decorate exosomes that loaded with anticancer therapeutics Paclitaxel (PTX) and miR122 that silence both the drug efflux pump MDR1 (multidrug-resistant protein-1) and the oncogenic gene ADAM10 (A Disintegrin and metalloproteinase domain-containing protein 10). GalNAc is the ligand that provides exosome targeting ability to bind the hepatocyte surface receptor ASGP-R (asialoglycoprotein-receptor) usually express on liver cancer cell surface abundantly. PTX is highly hydrophobic, when it is conjugated to a polymeric hydrophilic RNA as a prodrug, its water solubility increases 32000-fold. No toxicity was detected. The PTX conjugated RNA strands assembled into a 4-way junction RNA nanoparticle to harbor 24-copies of PTX and 1-copy of miR122. The 4WJ RNA nanoparticles are loaded into the exosome and are decorated with GalNAc as a targeting ligand using RNA nanotechnology. Binding studies demonstrated that the multispecific exosome selectively binds and internalizes into the HepG2 liver cancer cells, and delivers the PTX and miR122 into the cell cytosol, exhibiting the highest efficacy in killing the targeted cancer cells due to the multispecific effect comes from miR122, PTX, GalNAc, and Exos. The liver cancer tumor regressed significantly after systemic injection of the multispecific exosomes to mice xenograft-bearing liver cancer. The results demonstrate that exosomes can serve as a multivalent vector to carry ligands, RNAi, and chemical drugs as a multispecific strategy to treat incurable liver cancers. Citation Format: Xin Li, Satheesh Ellipilli, Hongzhi Wang, Wen-Jui Lee, Yuan Soon Ho, Peixuan Guo. Ligand-displaying-exosomes using RNA nanotechnology for targeted delivery of multispecific drugs for liver cancer regression [abstract]. In: Proceedings of the AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics; 2021 Oct 7-10. Philadelphia (PA): AACR; Mol Cancer Ther 2021;20(12 Suppl):Abstract nr P171.