gebhart/patrepeval huggingface dataset:
Growth kinetics of individual Al-Cu intermetallic compounds (2014)

The growth kinetics of Al-Cu intermetallic compounds (IMC) have been investigated on thin film couples and bonded samples in the range 150°C to 250°C using XRD, SEM/EDX and in-situ interface resistance monitoring. Individual diffusion constants D <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">o</sub> and activation energies E <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">a</sub> (1.01eV, 0.97eV, 1.23eV, 1.28eV) have been obtained from thin film couples for the main three IMC phases Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> Cu <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">9</sub> , AlCu and Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> Cu, and for the total IMC growth, respectively. Two additional phases (Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> Cu <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> , Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.06</sub> Cu <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.94</sub> ) contribute to the total IMC growth at T ≥ 200°C, but do not form at lower temperatures. Lower activation energies of 1.13eV (thin film) and 1.05eV (bonded samples) have thus been derived for T <; 200°C for the overall IMC growth and are recommended to be used for lifetime predictions in the typical regime of device application temperatures.
Rice-Ramsperger-Kassel-Marcus theoretical prediction of high-pressure Arrhenius parameters by nonlinear regression (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRice-Ramsperger-Kassel-Marcus theoretical prediction of high-pressure Arrhenius parameters by nonlinear regressionKarl F. Roenigk, Klavs F. Jensen, and Robert W. CarrCite this: J. Phys. Chem. 1987, 91, 22, 5726–5732Publication Date (Print):October 1, 1987Publication History Published online1 May 2002Published inissue 1 October 1987https://pubs.acs.org/doi/10.1021/j100306a042https://doi.org/10.1021/j100306a042research-articleACS PublicationsRequest reuse permissionsArticle Views53Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Asymmetric, Catalytic Synthesis of α‐Chiral Amines Using a Novel Bis(phosphine) Monoxide Chiral Ligand. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a TP53 -Dependent Manner (2021)

Epithelial ovarian carcinomas are particularly deadly due to intratumoral heterogeneity, resistance to standard-of-care therapies, and poor response to alternative treatments such as immunotherapy. Targeting the ovarian carcinoma epigenome with DNA methyltransferase inhibitors (DNMTi) or histone deacetylase inhibitors (HDACi) increases immune signaling and recruits CD8<sup>+</sup> T cells and natural killer cells to fight ovarian carcinoma in murine models. This increased immune activity is caused by increased transcription of repetitive elements (RE) that form double-stranded RNA (dsRNA) and trigger an IFN response. To understand which REs are affected by epigenetic therapies in ovarian carcinoma, we assessed the effect of DNMTi and HDACi on ovarian carcinoma cell lines and patient samples. Subfamily-level (TEtranscripts) and individual locus-level (Telescope) analysis of REs showed that DNMTi treatment upregulated more REs than HDACi treatment. Upregulated REs were predominantly LTR and SINE subfamilies, and SINEs exhibited the greatest loss of DNA methylation upon DNMTi treatment. Cell lines with <i>TP53</i> mutations exhibited significantly fewer upregulated REs with epigenetic therapy than wild-type <i>TP53</i> cell lines. This observation was validated using isogenic cell lines; the <i>TP53</i>-mutant cell line had significantly higher baseline expression of REs but upregulated fewer upon epigenetic treatment. In addition, p53 activation increased expression of REs in wild-type but not mutant cell lines. These data give a comprehensive, genome-wide picture of RE chromatin and transcription-related changes in ovarian carcinoma after epigenetic treatment and implicate p53 in RE transcriptional regulation. SIGNIFICANCE: This study identifies the repetitive element targets of epigenetic therapies in ovarian carcinoma and indicates a role for p53 in this process.
Evaluation of Receptor Binding Specificity ofEscherichia coliK88 (F4) Fimbrial Adhesin Variants Using Porcine Serum Transferrin and Glycosphingolipids as Model Receptors (2002)

Diarrheal disease caused by enterotoxigenic Escherichia coli expressing the K88 (F4) fimbrial adhesin (K88 ETEC) is a significant source of mortality and morbidity among newborn and weaned piglets. K88 fimbrial adhesins are filamentous surface appendages whose lectin (carbohydrate-binding) activity allows K88 ETEC to attach to specific glycoconjugates (receptors) on porcine intestinal epithelial cells. There are three variants of K88 adhesin (K88ab, K88ac, and K88ad), which possess different, yet related, carbohydrate-binding specificities. We used porcine serum transferrin (pSTf) and purified glycosphingolipids (GSL) to begin to define the minimal recognition sequence for K88 adhesin variants. We found that K88ab adhesin binds with high affinity to pSTf (dissociation constant, 75 microM), while neither K88ac nor K88ad adhesin recognizes pSTf. Degradation of the N-glycan on pSTf by extensive metaperiodate treatment abolished its interaction with the K88ab adhesin, indicating that the K88ab adhesin binds to the single N-glycan found on pSTf. Using exoglycosidase digestion of the pSTf glycan, we demonstrated that K88ab adhesin recognizes N-acetylglucosamine (GlcNAc) residues in the core of the N-glycan on pSTf. All three K88 variants were found to bind preferentially to GSL containing a beta-linked N-acetylhexosamine (HexNAc), either GlcNAc or N-acetylgalactosamine, in the terminal position or, alternatively, in the penultimate position with galactose in the terminal position. Considering the results from pSTf and GSL binding studies together, we propose that the minimal recognition sequence for the K88 adhesin variants contains a beta-linked HexNAc. In addition, the presence of a terminal galactose beta-linked to this HexNAc residue enhances K88 adhesin binding.
Modeling and Control of a Hybrid Fuel Delivery System Based on a Two-Phase Anodic Model of a PEM Fuel Cell (2010)

A polymer electrolyte membrane fuel cell (PEM FC) system for automotive applications should meet the rapid variable power demand by consuming the fuel, hydrogen. The fuel delivery system is designed to supply the hydrogen from tank to fuel cell system, and sometime re-circulate exhausted hydrogen to increase the fuel efficiency and maintain the humidity at the anode side for proper water management. The pressure in anode flow channel should track the pressure in cathode flow channel to prevent high pressure difference damage on the thin layers in cells with stable stiochiometric ratio of hydrogen. In this paper, we analyze a hybrid fuel delivery system that consists of two supply and two recirculation lines including a control valve, low pressure regulator, an ejector, and a blower. A quasi-1D two-phase transient fuel cell model is incorporated into the fuel delivery system for the design of controllers. A state feed-back controller were implemented and optimized, which is integrated with the fuel delivery and fuel cell system and be simulated to evaluate its tracking and rejection performance.
Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography (2006)

Magnetic resonance (MR)-guided near-infrared spectral tomography was developed and used to image adipose and fibroglandular breast tissue of 11 normal female subjects, recruited under an institutional review board-approved protocol. Images of hemoglobin, oxygen saturation, water fraction, and subcellular scattering were reconstructed and show that fibroglandular fractions of both blood and water are higher than in adipose tissue. Variation in adipose and fibroglandular tissue composition between individuals was not significantly different across the scattered and dense breast categories. Combined MR and near-infrared tomography provides fundamental molecular information about these tissue types with resolution governed by MR T1 images.
Imaging Thin Films of Nanoporous Low-k Dielectrics: Comparison between Ultramicrotomy and Focused Ion Beam Preparations for Transmission Electron Microscopy (2005)

Ultramicrotomy, the technique of cutting nanometers-thin slices of material using a diamond knife, was applied to prepare transmission electron microscope (TEM) specimens of nanoporous poly(methylsilsesquioxane) (PMSSQ) thin films. This technique was compared to focused ion beam (FIB) cross-section preparation to address possible artifacts resulting from deformation of nanoporous microstructure during the sample preparation. It was found that ultramicrotomy is a successful TEM specimen preparation method for nanoporous PMSSQ thin films when combined with low-energy ion milling as a final step. A thick, sacrificial carbon coating was identified as a method of reducing defects from the FIB process which included film shrinkage and pore deformation.
PAM-4 and DMT for Inter-Data Center Connections and 5G Fronthaul Applications (2018)

Modulation formats with intensity modulation (IM) and direct detection (DD) are attractive due to the simple optical configuration, the low power consumption and a small footprint. We revisit the performance of 56 Gb/s and 112 Gb/s four-level multilevel intensity modulation (PAM-4) and discrete multitone transmission (DMT) for wavelength multiplexed high speed connections with distances up to 80 – 100 km between data centers and for future 5G fronthaul architectures with a reach of 10 – 20 km. Enabled by digital signal processing (DSP) DMT as well as PAM-4 and its partial response variant are shown to be suitable for the proposed applications. The paper will discuss the specific pros and cons with respect to component properties and the required signal processing effort.
Search for neutral resonances decaying into a Z boson and a pair of b jets or τ leptons (2016)

A search is performed for a new resonance decaying into a lighter resonance and a Z boson. Two channels are studied, targeting the decay of the lighter resonance into either a pair of oppositely charged leptons or a bb pair. The Z boson is identified via its decays to electrons or muons. The search exploits data collected by the CMS experiment at a centre-of-mass energy of 8 TeV, corresponding to an integrated luminosity of 19.8 fb -1 . No significant deviations are observed from the standard model expectation and limits are set on production cross sections and parameters of two-Higgs-doublet models.
Optimizing experimental conditions for stimulated emission depletion microscopy in biophotonics (2015)

Using a novel numerical method we show how to optimize the resolution enhancement of stimulated emission depletion (STED) by simulating the entire process including the absorption, overlapping multiple beams and stimulated emission. We provide calculations showing that for fixed donut pulse energy, a longer donut pulse length can result in greater resolution enhancement than a shorter donut pulse length. These results show how it is possible to use our simulations to design the best experimental conditions for STED resolution enhancement and illustrate the importance of having a software program that includes both multiple beams and stimulated emission.
High quality factor etchless silicon photonic ring resonators (2010)

We demonstrate high-Q silicon ring resonators fabricated by selective oxidation without any silicon etching. We achieve an intrinsic quality factor of 510,000 in 50 μm-radius ring resonators with ring losses of 0.8 dB/cm.
Recent advances in neuroanaesthesia (2001)

In order to provide optimum intracranial operating conditions for neurosurgery, anaesthetists must have a thorough understanding of brain physiology and how this is affected by pathology and anaesthetic drugs and techniques. This article discusses the current understanding of cerebral vascular physiology and how novel neuroanaesthetic drugs and techniques affect it.
III-V on a Si platform for the next generations of communication systems (2022)

Compound semiconductors will play a crucial role in reaching the high datarates of future wireless systems operating in the mmWave or sub-THz bands at a decent energy consumption. Their compatibility with a Si platform is desired to enable a high level of integration (i.e., complex functionality), as well as large-volume, low-cost production. We report here the possibilities offered by nanoridge engineering to meet these targets.
Coplanarity by hydrogen bonding in well-defined oligoheterocycles (1996)

(Hetero)aryl-aryl coupling for covalent bonding and intramol. hydrogen bond formation for establishing the secondary structure have been united to design and construct well-defined, functionalized macromols. The suitability of azaheterocyclic units to realize this concept is exemplified by star shaped discotic liq. cryst. compds. and ladder-type conjugated copolymers. A review with &amp;gt;40 refs
Interspecies Differences in Reaction to a Biodegradable Subcutaneous Tissue Filler (2014)

Soft tissue filler products have become very popular in recent years, with ever-increasing medical and aesthetic indications. While generally considered safe, the number of reported complications with tissue fillers is growing. Nevertheless, there is no specific animal model that is considered as the gold standard for assessing safety or efficacy of tissue fillers, and there are very little data on interspecies differences in reaction to these products. Here, we report on interspecies differences in reaction to a subcutaneous injectable co-polyester, composed of castor oil and citric acid. Comparison of the histopathological local tissue changes following 1-month postimplantation, indicated that in rats the reaction consisted of cavities, surrounded by relatively thin fibrotic enveloping capsule. In contrast, an unexpected severe inflammatory granulomatous reaction was noticed in Sinclair minipigs. To our knowledge, this is the first report on significant interspecies differences in sensitivity to tissue fillers. It emphasizes the importance of using the appropriate animal model for performing preclinical biocompatibility assays for biodegradable polymers, tissue fillers, and implanted medical devices in general. It also makes the Sinclair minipig subject for scrutiny as an animal model in future biocompatibility studies.
DNA origami protection and molecular interfacing through engineered sequence-defined peptoids (2020)

DNA nanotechnology has established approaches for designing programmable and precisely controlled nanoscale architectures through specific Watson-Crick base-pairing, molecular plasticity, and intermolecular connectivity. In particular, superior control over DNA origami structures could be beneficial for biomedical applications, including biosensing, in vivo imaging, and drug and gene delivery. However, protecting DNA origami structures in complex biological fluids while preserving their structural characteristics remains a major challenge for enabling these applications. Here, we developed a class of structurally well-defined peptoids to protect DNA origamis in ionic and bioactive conditions and systematically explored the effects of peptoid architecture and sequence dependency on DNA origami stability. The applicability of this approach for drug delivery, bioimaging, and cell targeting was also demonstrated. A series of peptoids (PE1-9) with two types of architectures, termed as "brush" and "block," were built from positively charged monomers and neutral oligo-ethyleneoxy monomers, where certain designs were found to greatly enhance the stability of DNA origami. Through experimental and molecular dynamics studies, we demonstrated the role of sequence-dependent electrostatic interactions of peptoids with the DNA backbone. We showed that octahedral DNA origamis coated with peptoid (PE2) can be used as carriers for anticancer drug and protein, where the peptoid modulated the rate of drug release and prolonged protein stability against proteolytic hydrolysis. Finally, we synthesized two alkyne-modified peptoids (PE8 and PE9), conjugated with fluorophore and antibody, to make stable DNA origamis with imaging and cell-targeting capabilities. Our results demonstrate an approach toward functional and physiologically stable DNA origami for biomedical applications.
Simultaneous temperature and magnetization transfer (MT) monitoring during high‐intensity focused ultrasound (HIFU) treatment: Preliminary investigation on ex vivo porcine muscle (2009)

In a protocol of spot-by-spot heating over a large volume of tissue, MTR provides additional values to mark the locations of previously heated regions. By continuously recording the locations of heated spots, MTR maps could help plan the next target spots appropriately, potentially improving the efficiency of HIFU treatment and reducing undesirable damage to the normal tissue.
Mitigation of Control Channel Jamming under Node Capture Attacks (2009)

Availability of service in many wireless networks depends on the ability for network users to establish and maintain communication channels using control messages from base stations and other users. An adversary with knowledge of the underlying communication protocol can mount an efficient denial of service attack by jamming the communication channels used to exchange control messages. The use of spread spectrum techniques can deter an external adversary from such control channel jamming attacks. However, malicious colluding insiders or an adversary who captures or compromises system users is not deterred by spread spectrum, as they know the required spreading sequences. For the case of internal adversaries, we propose a framework for control channel access schemes using the random assignment of cryptographic keys to hide the location of control channels. We propose and evaluate metrics to quantify the probabilistic availability of service under control channel jamming by malicious or compromised users and show that the availability of service degrades gracefully as the number of colluding insiders or compromised users increases. We propose an algorithm called GUIDE for the identification of compromised users in the system based on the set of control channels that are jammed. We evaluate the estimation error using the GUIDE algorithm in terms of the false alarm and miss rates in the identification problem. We discuss various design trade-offs between robustness to control channel jamming and resource expenditure.
ChemInform Abstract: Phospholipase A2 Inhibition and Modification by Manoalogue. (1988)

Abstract The analogues (XI), (XII) and (XIII) of the marine natural product manoalide are synthesized as outlined in the scheme.
Cilansetron hydrochloride monohydrate, modification B (orthorhombic) (2002)

The absolute configuration of the orthorhombic form of the title compound, (−)-5,6,9,10-tetra­hydro-10-[(2-methyl-1H-imid­azol-1-yl)­methyl]-4H-pyrido­[3,2,1-jk]­carbazol-11(8H)-one mono­hydro­chloride monohydrate, C20H22N3O+·Cl−·H2O, was established as R at the asymmetric carbon adjacent to the carbonyl function. This form [cf. the monoclinic form; Jones et al. (2003). Acta Cryst. E59, o38–o40] also involves two independent formula units with different ring conformations of the six-membered N-heterocycle, and somewhat different orientations of the imidazole ring. Classical hydrogen bonding leads to a helical chain of alternating water and chloride residues, with cations hydrogen bonded laterally to the water molecules.
PressureVision++: Estimating Fingertip Pressure from Diverse RGB Images (2023)

Touch plays a fundamental role in manipulation for humans; however, machine perception of contact and pressure typically requires invasive sensors. Recent research has shown that deep models can estimate hand pressure based on a single RGB image. However, evaluations have been limited to controlled settings since collecting diverse data with ground-truth pressure measurements is difficult. We present a novel approach that enables diverse data to be captured with only an RGB camera and a cooperative participant. Our key insight is that people can be prompted to apply pressure in a certain way, and this prompt can serve as a weak label to supervise models to perform well under varied conditions. We collect a novel dataset with 51 participants making fingertip contact with diverse objects. Our network, PressureVision++, outperforms human annotators and prior work. We also demonstrate an application of PressureVision++ to mixed reality where pressure estimation allows everyday surfaces to be used as arbitrary touch-sensitive interfaces. Code, data, and models are available online.