gebhart/patrepeval huggingface dataset:
TAGLN2 regulates T cell activation by stabilizing the actin cytoskeleton at the immunological synapse (2015)

Extracellular vesicles (EVs), such as exosomes and microvesicles, are released by different cell types and participate in physiological and pathophysiological processes.EVs mediate intercellular communication as cell-derived extracellular signalling organelles that transmit specific information from their cell of origin to their target cells.As a result of these properties, EVs of defined cell types may serve as novel tools for various therapeutic approaches, including (a) anti-tumour therapy, (b) pathogen vaccination, (c) immune-modulatory and regenerative therapies and (d) drug delivery.The translation of EVs into clinical therapies requires the categorization of EV-based therapeutics in compliance with existing regulatory frameworks.As the classification defines subsequent requirements for manufacturing, quality control and clinical investigation, it is of major importance to define whether EVs are considered the active drug components or primarily serve as drug delivery vehicles.For an effective and particularly safe translation of EV-based therapies into clinical practice, a high level of cooperation between researchers, clinicians and competent authorities is essential.In this position statement, basic and clinical scientists, as members of the International Society for Extracellular Vesicles (ISEV) and of the European Cooperation in Science and Technology (COST) program of the European Union, namely European Network on Microvesicles and Exosomes in Health and Disease (ME-HaD), summarize recent developments and the current knowledge of EV-based therapies.Aspects of safety and regulatory requirements that must be considered for pharmaceutical manufacturing and clinical application are highlighted.Production and quality control processes are discussed.Strategies to promote the therapeutic application of EVs in future clinical studies are addressed.
ChemInform Abstract: Evolution of Catalytic Stereoselective Olefin Metathesis: From Ancillary Transformation to Purveyor of Stereochemical Identity (2014)

Abstract Review: [121 refs.
ChemInform Abstract: Synthesis and Characterization of Photoswitchable Lipids Containing Hemithioindigo Chromophores. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Flexible Transparent Conductive Films with High Performance and Reliability Using Hybrid Structures of Continuous Metal Nanofiber Networks for Flexible Optoelectronics (2017)

We report an Ag nanofiber-embedded glass-fabric reinforced hybrimer (AgNF-GFRHybrimer) composite film as a reliable and high-performance flexible transparent conducting film. The continuous AgNF network provides superior optoelectronic properties of the composite film by minimizing transmission loss and junction resistance. In addition, the excellent thermal/chemical stability and mechanical durability of the GFRHybrimer matrix provides enhanced mechanical durability and reliability of the final AgNF-GFRHybrimer composite film. To demonstrate the availability of our AgNF-GFRHybrimer composite as a transparent conducting film, we fabricated a flexible organic light-emitting diode (OLED) device on the AgNF-GFRHybrimer film; the OLED showed stable operation during a flexing.
Methodologies and Tools for Intelligent Agents in Distributed Control (2005)

Agent technology also provides an appropriate framework to integrate knowledge with production actions. Knowledge integration depends on balanced information in and across organizations. So, replacing the central models with distributed intelligent agents make it possible to cope with demands more efficiently. In this, each agent represents a specific activity to support overall operations. With agents, maintaining the overall system is easier because instead of changes occurring to a colossal program, changes take place on a small scale without disrupting overall operations. We've developed a set of tools and methodologies to help design, build, test, and verify such systems. Using these tools and methodologies, we've devised an agent architecture that we've applied to a US Navy shipboard chilled-water system.
Vehicle Longitudinal Ride Comfort Control in Stop-and-Go Traffic (2006)

Ride comfort at low vehicle speed is often overlooked but is very important to vehicle control applications (e.g. the latest stop-and-go function in Adaptive Cruise Control). Most control strategies that address passenger comfort simply utilize the bounds of jerk and acceleration of the vehicles. In general, they have several major limitations when applied to low-speed applications: (I) frequency-domain comfort requirements are not integrated and (II) the vehicle models are simplified too far to capture the tire and suspension dynamics that may impact comfort significantly at low speeds. This paper develops a control scheme for ride quality under stop-and-go situations. The scheme is based on optimal control and it ensures smooth acceleration during vehicle maneuvers. A two-degree-of-freedom control strategy is used to approximate the optimal control law. Experimental results demonstrate the effectiveness of this control scheme.
Spermatocyte/Spermatid-specific Thioredoxin-3, a Novel Golgi Apparatus-associated Thioredoxin, Is a Specific Marker of Aberrant Spermatogenesis (2004)

Mammalian germ cells are endowed with a complete set of thioredoxins (Trx), a class of redox proteins located in specific structures of the spermatid and sperm tail. We report here the characterization, under normal and pathological conditions, of a novel thioredoxin with a germ line-restricted expression pattern, named spermatocyte/spermatid-specific thioredoxin-3 (SPTRX-3). The human SPTRX-3 gene maps at 9q32, only 50 kb downstream from the TRX-1 gene from which it probably originated as genomic duplication. Therefore, human SPTRX-3 protein comprises a unique thioredoxin domain displaying high homology with the ubiquitously expressed TRX-1. Among the tissues investigated, Sptrx-3 mRNA is found exclusively in the male germ cells at pachytene spermatocyte and round spermatid stages. Light and electron microscopy show SPTRX-3 protein to be predominately located in the Golgi apparatus of pachytene spermatocytes and round and elongated spermatids, with a transient localization in the developing acrosome of round spermatids. In addition, increased levels of SPTRX-3, possibly caused by overexpression, are observed in morphologically abnormal human spermatozoa from infertile men. In addition, SPTRX-3 is identified as a novel postobstruction autoantigen. In this report, we propose that SPTRX-3 can be used as a specific marker for diverse sperm and testis pathologies. SPTRX-3 is the first thioredoxin specific to the Golgi apparatus, and its function within this organelle might be related to the post-translational modification of proteins required for germ cell-specific functions, such as acrosomal biogenesis.
The Role of Diagnostic Nerve Blocks in Headache Surgery (2021)

BACKGROUND: Evidence-based patient selection in headache surgery is extremely important to achieve satisfactory outcomes. In headache surgery, nerve blocks have become an important diagnostic tool to confirm trigger sites and to identify suitable candidates for surgery. Wide availability, low cost, easy administration, and immediate patient feedback make nerve blocks an attractive in- office screening tool. Resolution of headache symptoms after nerve block has been seen as a good prognostic sign based on expert opinion. However, the relationship between nerve block response and surgical outcome has not been studied. METHODS: Patients were asked to stop their regular pain medication and present to the office in pain. If patients had no pain at the time of the visit, they were asked to return when they experienced their next headache/ migraine. All patients with suspected nerve compression underwent a diagnostic nerve block. Pre- and post- injection pain scores (on a 0–10 scale) were recorded prospectively at each injected site to quantify improvement/ worsening of pain. A positive response to the nerve block was defined as ≥50% decrease in pain score. Further, the length of nerve block response was documented by follow-up phone call, and during subsequent clinical visits. Surgical outcomes were documented prospectively by calculating the Migraine Headache Index scores preoperatively, at 3 months, 12 months, and every year thereafter [migraine headache frequency (0–30) × pain (on a scale of 0–10) × duration (1/24)]. Nerve block response was correlated with surgical outcome. RESULTS: The study population included 117 patients who underwent a preoperative nerve block. Of these, 90% (n = 105) achieved ≥50% immediate pain relief following nerve block (positive response). Mean follow-up time was 13 months for patients with successful nerve block and 9.8 months for patients with unsuccessful nerve block (P = 0.03). The mean MHI score improvement was significantly greater in patients who responded positively to nerve block (74 ± 37%) than in those who did not (59 ± 44.6%; P = 0.02). With respect to duration of response to nerve block, patients who reported relief for ≥24 hours achieved a significantly greater mean reduction in MHI scores (P = 0.02, 76.1 ± 35.8% versus 49.7± 40.7%). CONCLUSIONS: Headache surgery patients who respond positively to preoperative nerve blocks achieve better surgical outcomes when compared with patients who have a limited response. Given these findings, nerve blocks should be considered as a preoperative screening tool for headache surgery.
Human Factors Design for Intuitive Operation of a Low-cost, Image-Guided, Tele-Robotic Biopsy Assistant (2007)

This paper details the design and interface development of Robopsy, an economical, tele-operated, patient mounted, disposable needle guidance and insertion system to assist radiologists in performing minimally invasive percutaneous biopsies remotely under CT guidance. Testing with a phantom in a realistic surgical setting was conducted to ensure that the interface was intuitive and facilitated smooth integration of the device into current procedure. Ease of learning and operation is critical in order to encourage rapid adoption of this new medical robotics model.
Eaton Agent Pneumonia (1961)

The ecology of infection with Eaton agent was studied at a Marine training center using the fluorescent antibody technique. The serologic findings supported the contention that this filterable agent was associated with atypical pneumonia. Infection was detected significantly more frequently among recruits with pneumonia or febrile respiratory disease than in a control group of persons free of respiratory symptoms. One hundred and sixty-one of patients with pneumonia were serologically positive, and Eaton agent was recovered in tissue culture from 14 to 17 such recruits. Approximately 44 per cent of recruits were infected at some time during their 3-month training period. Only 1 in 30 such infections was manifest as a clinically diagnosed pneumonia. The data suggested that Eaton agent was not highly communicable, an attribute which favored its persistence in the recruit population.
A 1-GHz CMOS up-conversion mixer (1997)

A high-frequency linear MOS mixer topology is presented for the implementation of a 1-GHz up-conversion mixer in a standard 0.7-/spl mu/m CMOS technology. The high output bandwidth has been achieved by the development of an nMOS-only current amplifier that converts the modulated current of the nMOS mixing transistor biased in the linear region to the RF output voltage.
A Trust-Aware, P2P-Based Overlay for Intrusion Detection (2006)

Collaborative intrusion detection systems (IDSs) have a great potential for addressing the challenges posed by the increasing aggressiveness of current Internet attacks. However, one of the major concerns with the proposed collaborative IDSs is their vulnerability to the insider threat. Malicious intruders, infiltrating such a system, could poison the collaborative detectors with false alarms, disrupting the intrusion detection functionality and placing at risk the whole system. In this paper, we propose a P2P-based overlay for intrusion detection (overlay IDS) that addresses the insider threat by means of a trust-aware engine for correlating alerts and an adaptive scheme for managing trust. We have implemented our system using JXTA framework and we have evaluated its effectiveness for preventing the spread of a real Internet worm over an emulated network. The evaluation results show that our overlay IDS significantly increases the overall survival rate of the network
Supramolecular Hydrogen-Bonded Oligo(p-phenylene vinylene) Polymers (2001)

Eine Kombination aus den wohldefinierten Merkmalen π-konjugierter Oligomere und den Materialeigenschaften von Polymeren weisen die supramolekularen Wasserstoffbrücken-gebundenen π-konjugierten Architekturen der Titelverbindung auf (siehe Bild). Diese Verbindungen wurden erstmals erfolgreich in elektronischen Bauelementen eingesetzt.
Addendum to “Search and Breast Cancer: On Episodic Shifts of Attention over Life Histories of an Illness” (1999)

This is a publication addendum for the article “Search and Breast Cancer: On Episodic Shifts of Attention over Life Histories of an Illness”, accepted for ACM Transactions on the Web. Ontology.txt contains the Breast Cancer Search Term Ontology referenced in the article. See the README.txt for more details on the file format.
Walking robot with a circulating gait (2002)

The Ambler walking robot has been developed specifically for autonomous exploration of planetary and lunar surfaces. The Ambler, which maintains its body on a level trajectory while walking, has unique orthogonal legs that are stacked under the body instead of the traditional animal-like arrangement of legs around the body. The resulting stacked configuration leads to a novel circulating gait that promises to improve mobility in terrains of extreme roughness. The Ambler's level body motion, orthogonal legs, and circulating gait greatly simplify physical control, terrain model construction, and motion planning-all of which are traditional impediments to autonomous travel across rough terrain.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Deep Unrolled Recovery in Sparse Biological Imaging: Achieving fast, accurate results (2022)

Deep algorithm unrolling has emerged as a powerful, model-based approach to developing deep architectures that combine the interpretability of iterative algorithms with the performance gains of supervised deep learning, especially in cases of sparse optimization. This framework is well suited to applications in biological imaging, where physics-based models exist to describe the measurement process and the information to be recovered is often highly structured. Here we review the method of deep unrolling and show how it improves source localization in several biological imaging settings.
Applicability of Compounded Mesh Method to Three-Dimensional Interface Problems : 2nd. Report, Application to Interface Crack Problems (2002)

In the first report, the formulation of the compounded mesh method was given, and the applicability of the method was studied through numerical examples of interface edge problems. In this paper, three-dimensional center-through interface crack model is studied. Two mesh patterns are prepared. One mesh pattern is for the crack singularity and the other mesh is for interface edge singularity. These two mesh patterns are compounded, and the applicability of this method is studied.
Micrometre resolution of a charge integrating microstrip detector with single photon sensitivity (2012)

A synchrotron beam has been used to test the spatial resolution of a single-photon-resolving integrating readout-chip coupled to a 320 µm-thick silicon strip sensor with a dedicated readout system. Charge interpolation methods have yielded a spatial resolution of σ(x) ≃ 1.8 µm for a 20 µm-pitch strip.
A First-Order Dynamics and Cost Comparison of Wave Energy Converters Combined With Floating Wind Turbines (2017)

Attaching a wave energy converter to a floating wind turbine (FWT-WEC) produces cost savings by sharing the mooring lines, electric transmission lines, and site permitting. We investigate if certain parameters can produce synergistic dynamics: maximized WEC power, minimized WEC cost, and minimized FWT motion. Our approach is to model the dynamics using first-order linear coupled equations of motion and long wave-length approximations. We compute representative annual response statistics of FWT-WEC systems for WEC's at various locations, and with different motion directions and power takeoff systems. It seems unlikely that a dynamically synergistic FWT-WEC configuration exists. However, the results of each FWT-WEC pair suggests that the WEC's could be used as building blocks for triple combined tuned mass damper-FWT-WEC or ballast-FWT-WEC systems to achieve both low-cost wave power and reduced FWT motion.
Combined Spectroscopic and Thermodynamic Investigation of Nextel‐720 Fiber/Alumina Ceramic‐Matrix Composite in Air and Water Vapor at 1100°C (2003)

The high‐temperature performance of a Nextel‐720 fiber/Al 2 O 3 composite in air and water vapor at 1100°C was investigated using X‐ray photoelectron spectroscopy (XPS) and thermodynamic calculations. In the presence of water vapor, the formation of volatile Si(OH) 4 was responsible for the loss of mullite phase in the fiber of the ceramic‐matrix composite (CMC). XPS analysis revealed the formation of surface aluminosilicates for the water‐vapor‐exposed CMC for 1000 h.
Synthesis of Sulfonyl Chlorides of Phenylboronic Acids. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
THE BORN GLOBAL MODEL FOR ROMANIAN SMALL AND MEDIUM ENTERPRISES INTERNATIONALIZATION (2009)

ABSTRACT. The article analyses the possibilities for Romanian small and medium enterprises to internationalize as Born Globals. Small and medium enterprises in European economies and all over the world are more and more exposed to global pressures induced by globalization and market integration processes, which amplifies the need to be competitive and confront international markets through internationalization. Small and medium enterprises internationalization is an amplifying phenomenon, which has been the topic of wide spread research efforts in the last decades. The most recent trend in this field is the Born Global model, which points out to small and medium enterprises that show very rapid and intensive international growth right from or close to inception. In order to investigate the small and medium enterprises internationalization possibilities as Born Globals, several major underlying factors of the emergence of Born Globals are considered, representing both internal and external push and pull forces to internationalization. The applicability of the Born Global model of internationalization for Romanian small and medium enterprises is outlined by the examination of each factor’s triggering role in the current Romanian context. Based on this analysis, consequent policy recommendations for stimulating the Romanian small and medium enterprises internationalization as Born Globals are proposed.
Example Based Single-Frame Image Super-Resolution by Support Vector Regression (2010)

The Journal of Pattern Recognition Research (JPRR) provides an open access forum for the publication of research articles in areas of pattern recognition, machine learning, artificial intelligence, computational algorithms, and fuzzy learning
Low-temperature reactions of methane with photoexcited nickel atoms (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLow-temperature reactions of methane with photoexcited nickel atomsSou Chan Chang, Robert H. Hauge, W. E. Billups, John L. Margrave, and Zakya H. KafafiCite this: Inorg. Chem. 1988, 27, 1, 205–206Publication Date (Print):January 1, 1988Publication History Published online1 May 2002Published inissue 1 January 1988https://pubs.acs.org/doi/10.1021/ic00274a043https://doi.org/10.1021/ic00274a043research-articleACS PublicationsRequest reuse permissionsArticle Views92Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Estimation of the drill bit angular velocity using accelerometer measurements and extended Kalman filters (2011)

In this paper, an extended Kalman filter model is proposed to estimate the angular velocity of a drilling shaft based on the accelerometer measurements of a downhole recording tool mounted on the drill rod. The method allows tracking the severity of torsional vibrations in real-time. The results outline the advantages of the proposed method in particular its ability to capture events of backward rotation known to be very detrimental to the life of drill bits.
HYPERTONIC SALINE BLUNTS THE INFLAMMATORY AND PROTHROMBOGENIC PHENOTYPE ASSUMED BY THE CEREBRAL MICROCIRCULATION IN SEPTIC OBESE MICE. (2005)

Vachharajani, Vidula T; Vital, Shantel A; Scott, Louie K; Granger, Daniel N Author Information
An Inductive Coupler Array for In-Motion Wireless Charging of Electric Vehicles (2021)

An inductive power transfer (IPT) system is envisaged as the best solution to conveniently charge electric vehicles (EVs). While stationary IPT systems are becoming commercialized, significant research is being conducted to address the challenges related to dynamic IPT systems. Dynamic or in-motion IPT systems require a fully electrified roadway with embedded inductive couplers with accompanying circuitry. The large number of electronic components required, however, increases the system complexity, reducing the reliability and economic viability of dynamic IPT systems proposed to-date. This article proposes a simple yet robust push-pull driven coupler array (PPCA), aiming to decrease the number of switches required to drive the in-road couplers. This article is the first to report a configuration where only N+1 switches are required to independently energize N primary IPT couplers. Any number of couplers can be activated simultaneously in the array without proportionally increasing the current stress on the switches. A state-space model is developed and implemented in PLECS to investigate the efficiency and power transferred to an EV traveling over the proposed PPCA while considering the variation in the coupling and the self-inductances of the couplers. A 3.3-kW scaled prototype PPCA consisting of three primary couplers and two secondary couplers has been implemented to validate the performance of the proposed configuration.
Supplementary Figure Legends 1-6 from Loss of E-Cadherin Promotes Metastasis via Multiple Downstream Transcriptional Pathways (2023)

Supplementary Figure Legends 1-6 from Loss of E-Cadherin Promotes Metastasis via Multiple Downstream Transcriptional Pathways