gebhart/patrepeval huggingface dataset:
Modeling dynamic prosodic variation for speaker verification (1998)

Statistics of frame-level pitch have recently been used in speaker recognition systems with good results [1, 2, 3]. Although they convey useful long-term information about a speaker’s distribution of f0 values, such statistics fail to capture information about local dynamics in intonation that characterize an individual’s speaking style. In this work, we take a first step toward capturing such suprasegmental patterns for automatic speaker verification. Specifically, we model the speaker’s f0 movements by fitting a piecewise linear model to the f0 track to obtain a stylized f0 contour. Parameters of the model are then used as statistical features for speaker verification. We report results on 1998 NIST speaker verification evaluation. Prosody modeling improves the verification performance of a cepstrum-based Gaussian mixture model system (as measured by a task-specific Bayes risk) by 10%.
Application of Polymerization Kinetic Modeling in High‐Throughput Screening of Catalyst Systems for Productivity (2007)

Abstract In high‐throughput research, it is essential to use “right data” and “meaningful parameters” to reach reliable conclusions. The complexity and the large amount of data obtained from each set of experiments make the analysis of reaction data a nontrivial task. The important role of reaction kinetic modeling in the analysis of polymerization reaction data is discussed, and it is shown that the application of traditional methods for the determination of catalyst productivity can be misleading. Reaction kinetic modeling provides meaningful parameters for data analysis, gives complete information about the polymerization kinetic profile, and makes it possible to evaluate assumptions and hypotheses. magnified image
Spin readout of nitrogen-vacancy centers with plasmonic nanostructures (Conference Presentation) (2018)

Nitrogen-vacancy (NV) color centers in diamond possess electronic spins that one can manipulate coherently at room temperature using RF signals. The optical spin readout plays a key role in their performance for nanoscale magnetometry and quantum information processing. We demonstrate that plasmonic nanostructures can simultaneously guide optical, microwave and low-frequency signals ensuring spin manipulation and readout in an ultracompact setting. They can also enhance detected photon rates through efficient photon collection and shortening of the fluorescence lifetime. We show that in the case of dense NV ensembles the design of the optical readout interface must emphasize photon collection efficiency over Purcell enhancement. However, in the case of single NV centers, large Purcell enhancement may significantly improve the spin readout sensitivity. Enhancement for high-fidelity readout can be provided by nanoparticle-on-metal antennas featuring ultraconfined plasmonic modes.
Polystyrene latex particles bearing primary amine groups via soap‐free emulsion polymerization (2020)

Abstract Polystyrene latexes were prepared in the presence of an amino‐containing functional comonomer, N ‐(3‐aminopropyl)methacrylamide hydrochloride (APMH), via soap‐free batch emulsion polymerization initiated by the cationic initiator 2,2′‐azobis(2‐amidinopropane) dihydrochloride. These latexes were characterized by studying the influence of the ionic comonomers on the polymerization kinetics, particle size, surface charge density and colloidal properties. The synthesized latexes were monodisperse with a final size between 100 and 600 nm depending on the APMH concentration. The initial polymerization rate and the particle number increased in accordance with the Smith–Ewart theory for soap‐free styrene emulsion polymerization with a hydrophilic functional comonomer. The final functionalization rate of the particles has been particularly studied with the intention of fitting the prepared latexes to be used in the immobilization of biological molecules for biological sample preparation and diagnostic applications. © 2020 Society of Chemical Industry
Understanding materials challenges for rechargeable ion batteries with in situ transmission electron microscopy (2017)

Abstract An in-depth understanding of material behaviours under complex electrochemical environment is critical for the development of advanced materials for the next-generation rechargeable ion batteries. The dynamic conditions inside a working battery had not been intensively explored until the advent of various in situ characterization techniques. Real-time transmission electron microscopy of electrochemical reactions is one of the most significant breakthroughs poised to enable radical shift in our knowledge on how materials behave in the electrochemical environment. This review, therefore, summarizes the scientific discoveries enabled by in situ transmission electron microscopy, and specifically emphasizes the applicability of this technique to address the critical challenges in the rechargeable ion battery electrodes, electrolyte and their interfaces. New electrochemical systems such as lithium–oxygen, lithium–sulfur and sodium ion batteries are included, considering the rapidly increasing application of in situ transmission electron microscopy in these areas. A systematic comparison between lithium ion-based electrochemistry and sodium ion-based electrochemistry is also given in terms of their thermodynamic and kinetic differences. The effect of the electron beam on the validity of in situ observation is also covered. This review concludes by providing a renewed perspective for the future directions of in situ transmission electron microscopy in rechargeable ion batteries.
Is Vitamin C Intake too Low in Dialysis Patients? (2012)

Vitamin C has several well-established roles in physiology including synthesis of collagen, carnitine and epinephrine, absorption of dietary iron, and mobilization of storage iron for erythropoeisis. Loss of several of these functions explains the pathology of scurvy, where defective collagen synthesis and anemia are major symptoms. Vitamin C deficiency is very common in dialysis patients and may arise from dialytic vitamin C clearance, restricted intake of vitamin C-rich foods, and increased vitamin C catabolism in vivo from inflammation. In the dialysis population, greater vitamin C intake may be needed for optimal health. Relationships between intake, body distribution, inflammation, and dialytic losses are complex and need further study. Concern about vitamin C metabolism leading to accumulation of tissue oxalate has led to the recommendation that vitamin C intake equals, but not exceeds, the intake recommended for the general population. Vitamin C deficiency in dialysis patients may have clinical consequences; a study in Renal Research Institute clinics found an association with periodontal disease. Data also support a role for vitamin C in prevention of dialysis-related anemia. New research questions are proposed in this editorial, with a discussion of strategies to determine the optimal provision of vitamin C for CKD patients.
Pandemic 2009 H1N1 vaccine protects against 1918 Spanish influenza virus (2010)

The 1918 influenza A virus caused the most devastating pandemic, killing approximately 50 million people worldwide. Immunization with 1918-like and classical swine H1N1 virus vaccines results in cross-protective antibodies against the 2009 H1N1 pandemic influenza, indicating antigenic similarities among these viruses. In this study, we demonstrate that vaccination with the 2009 pandemic H1N1 vaccine elicits 1918 virus cross-protective antibodies in mice and humans, and that vaccination or passive transfer of human-positive sera reduced morbidity and conferred full protection from lethal challenge with the 1918 virus in mice. The spread of the 2009 H1N1 influenza virus in the population worldwide, in addition to the large number of individuals already vaccinated, suggests that a large proportion of the population now have cross-protective antibodies against the 1918 virus, greatly alleviating concerns and fears regarding the accidental exposure/release of the 1918 virus from the laboratory and the use of the virus as a bioterrorist agent.
Effects of long-term vestibular rehabilitation therapy with vibrotactile sensory augmentation for people with unilateral vestibular disorders – A randomized preliminary study (2019)

Incorporating vibrotactile SA into vestibular rehabilitation programs may lead to additional benefits that may be retained up to six months after training compared to training without vibrotactile SA. A larger study is warranted to demonstrate statistical significance between the groups.
Figure S5 from Gamma Secretase Inhibition by BMS-906024 Enhances Efficacy of Paclitaxel in Lung Adenocarcinoma (2023)

&lt;p&gt;BMS-906024 enhances the anti-tumor activity of paclitaxel in vivo.&lt;/p&gt;
Progressing Bevacizumab-Induced Diffusion Restriction Is Associated with Coagulative Necrosis Surrounded by Viable Tumor and Decreased Overall Survival in Patients with Recurrent Glioblastoma (2016)

Progressive diffusion-restricted lesions were pathologically confirmed to be coagulative necrosis surrounded by viable tumor and associated with decreased overall survival. Stable lesions were, however, associated with increased overall survival. All lesions were associated with O<sup>6</sup>-methylguanine-DNA-methyltransferase unmethylated tumors.
Effect of constant exposure to cattle persistently infected with bovine viral diarrhea virus on morbidity and mortality rates and performance of feedlot cattle (2013)

Exposure of cattle to BVDV naturally or through vaccination before or at feedlot arrival mitigated the negative effects of constant exposure to PI cattle.
Comparison of thiocyanate and selenocyanate for potentiation of antimicrobial photodynamic therapy (2018)

We have previously shown that antimicrobial photodynamic therapy (aPDT) mediated by different photosensitizers (PS) can be potentiated by a variety of inorganic salts. Potassium thiocyanate (KSCN) potentiated aPDT mediated by methylene blue (MB), while potassium selenocyanate (KSeCN) potentiated aPDT mediated by MB, Rose Bengal and the anionic porphyrin 5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrin dihydrochloride. However, the mechanisms of action that were proposed were fundamentally different. In the present study, we compare these two salts (KSCN and KSeCN) with different light-activated PS and different oxidative reactions for killing gram-positive and gram-negative bacteria. Overall KSeCN was more powerful than KSCN, and worked with a wider range of PS, while KSCN only worked with phenothiazinium salts. KSeCN produced killing when cells were added after light suggesting production of a semistable species called selenocyanogen (SeCN)<sub>2</sub> . We tested three different oxidative reactions that can all potentially kill bacteria: lead tetraacetate (Pb[OAc]<sub>4</sub> ); Fenton reagent (hydrogen peroxide [H<sub>2</sub> O<sub>2</sub> ] and ferrous sulfate) H<sub>2</sub> O<sub>2</sub> and horseradish peroxidase (HRP). In every case, KSeCN was substantially more effective (several logs) than KSCN in potentiating the bacterial killing. We conclude that (SeCN)<sub>2</sub> is the mediator for aPDT using KSeCN, while sulfur trioxide radical anion is the mediator for KSCN using phenothiaziums. For H<sub>2</sub> O<sub>2</sub> /HRP with KSCN, hypothiocyanite is proposed to be the antibacterial agent in the literature, while hyposelenocyanite is said not to exist. Pb[OAc]<sub>4</sub> is known to produce (SeCN)<sub>2</sub> from KSeCN as well as the analogous (SCN)<sub>2</sub> from KSCN. The mediators from Fenton reaction are unclear (pseudohalogen radical ions?) Both KSCN (which occurs naturally in the human body) and KSeCN may be clinically applicable.
A Retrofit Capacitive Sensing Occupancy Detector Using Fluorescent Lamps (2011)

This paper presents a retrofit system that exploits a fluorescent lamp's own stray electric fields for capacitive sensing. Occupancy detection for demand-side energy management is a key application. The experimental system demonstrates a detection range of 10 ft. between the lamp and the nearest edge of the occupant. A full system model is presented including the simulation of a lumped element capacitive model. The full system model is validated against experimental data.
Influence of beam geometry and tissue boundaries on thermal ultrasonic lesions (1999)

The size and shape of thermal lesions induced by high-intensity focused ultrasound (HIFU) are key factors in treating disease. Studies are being conducted to determine how HIFU beams and exposures can be designed to produce useful lesion attributes in specific target tissues. The studies include radially asymmetric beams and tissues with different acoustic absorption coefficients; sharp thermal gradients at such boundaries can significantly affect lesion geometry. Ocular tumor therapy uses asymmetric beams that produce lesions with ellipsoidal cross sections to facilitate treatments with closely packed lesion matrices. Three-dimensional simulations have analyzed heat patterns and lesions induced by these beams in irregular tumors whose geometry is derived from clinical serial-plane scans using 50-MHz diagnostic ultrasound. The simulations documented difficulties in treating boundary regions adjacent to the waterlike vitreous humor. Lesion results were consistent with in vitro and in vivo animal experiments. A related study involves an annular-array therapy system with a central rectangular aperture, housing a diagnostic array. The system (Spectrasonics, Inc.) is intended for treatments in various organs, including liver. Since the therapy beams are not radially symmetric, 3-D simulations and initial animal experiments have examined the asymmetry in induced temperature patterns and lesions. These investigations also addressed spurious grating peaks in axial intensity.
A facile technology for the high-throughput sequencing of the paired VH:VL and TCRβ:TCRα repertoires (2020)

Natively paired sequencing (NPS) of B cell receptors [variable heavy (VH) and light (VL)] and T cell receptors (TCRb and TCRa) is essential for the understanding of adaptive immunity in health and disease. Despite many recent technical advances, determining the VH:VL or TCRb:a repertoire with high accuracy and throughput remains challenging. We discovered that the recently engineered xenopolymerase, RTX, is exceptionally resistant to cell lysate inhibition in single-cell emulsion droplets. We capitalized on the characteristics of this enzyme to develop a simple, rapid, and inexpensive in-droplet overlap extension reverse transcription polymerase chain reaction method for NPS not requiring microfluidics or other specialized equipment. Using this technique, we obtained high yields (5000 to >20,000 per sample) of paired VH:VL or TCRb:a clonotypes at low cost. As a demonstration, we performed NPS on peripheral blood plasmablasts and T follicular helper cells following seasonal influenza vaccination and discovered high-affinity influenza-specific antibodies and TCRb:a.
Polymer‐Supported Organic Catalysts (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
O BIBLIOTECÁRIO E AS AÇÕES CULTURAIS: UM CAMPO DE ATUAÇÃO (2015)

A acao cultural vem tendo um valor importante na contribuicao para um novo paradigma da biblioteca moderna, dinâmica e criativa em direcao as geracoes futuras. Nesse sentido, o presente estudo aborda as praticas culturais desenvolvidas pelos bibliotecarios ressaltando as acoes culturais como um novo campo de atuacao para os profissionais da informacao/bibliotecarios. Conceitua a biblioteca com base na literatura cientifica, como um campo possivel de desenvolver acoes culturais com seus objetivos e funcoes. Define acao cultural, representada aqui como possibilidade de promover aprendizado cultural aos usuarios, como tambem a distincao entre acao cultural, fabricacao cultural e animacao cultural. Analisa o perfil do bibliotecario com enfase na sua atuacao como agente cultural frente as novas tendencias informacionais. Mostra os metodos e tecnicas utilizados pelos bibliotecarios na producao das atividades culturais, assim como os resultados obtidos atraves da entrevista aplicada com a gestora e descricao das acoes. A pesquisa e caracterizada como documental com abrangencia bibliografica, de abordagem qualitativa e natureza exploratoria- descritiva. A guisa de conclusao, enaltece a confirmacao de que e possivel desenvolver acoes culturais em bibliotecas, e que este fundamenta-se como um novo campo de atuacao para os bibliotecarios, pois promovem informacao, conhecimento e aprendizado cultural para os usuarios.Palavras-chave: Acoes culturais. Cultura. Profissional da Informacao. Perfil do bibliotecario.
Detection of IgE Antibodies Specific for Allergens in Cow Milk and Cow Dander (1993)

Sera from patients with cow milk protein allergy (n = 6) and cow dander allergy (n = 5) were analyzed for reactivity of IgE antibodies specific for allergens derived from milk and cow dander. The cow milk- and cow dander-allergic patients exhibited elevated specific IgE levels to milk and to cow dander, respectively, as determined by RAST. IgE immunoblot analysis revealed that cow milk-allergic patients exhibited IgE binding to the milk allergens casein, beta-lactoglobulin, alpha-lactalbumin and bovine serum albumin. Four of six cow milk-reactive patients also exhibited IgE binding to cow dander proteins with molecular weights of 20, 22, 36, 50 and > 200 kD. IgE from the sera of cow dander-allergic patients reacted with the major allergens of cow dander (20 and 22 kD) and with other proteins with molecular weights of 24, 36, 42, 50 and 70 kD. Only one out of five of these sera displayed IgE reactivity with cow milk proteins with molecular weights of 69, 92 and > 200 kD. Inhibition studies revealed the cross-reactive nature of the IgE antibodies. Preincubation of cow milk-positive sera with cow milk and subsequent immunoblotting led to complete blocking of IgE binding to cow dander proteins and to cow milk proteins. Preincubation of cow milk-positive sera with cow dander extract led to blocking of IgE binding only to defined cow milk proteins: these could be identified in 2 cases as casein and in 1 case as beta-lactoglobulin.(ABSTRACT TRUNCATED AT 250 WORDS)
Polyclonal B Cell Differentiation and Loss of Gastrointestinal Tract Germinal Centers in the Earliest Stages of HIV-1 Infection (2020)

The antibody response to HIV-1 does not appear in the plasma until approximately 2–5 weeks after transmission, and neutralizing antibodies to autologous HIV-1 generally do not become detectable until 12 weeks or more after transmission. Moreover, levels of HIV-1–specific antibodies decline on antiretroviral treatment. The mechanisms of this delay in the appearance of anti-HIV-1 antibodies and of their subsequent rapid decline are not known. While the effect of HIV-1 on depletion of gut CD4+ T cells in acute HIV-1 infection is well described, we studied blood and tissue B cells soon after infection to determine the effect of early HIV-1 on these cells.
Retinex-based signal enhancement for image dark regions (2017)

To improve text detection and text recognition in natural scenes, it is important to improve legibility by removing the effects of illumination on the image. Therefore, in this study, we present a signal enhancement method for the dark regions in the image. In addition, we propose a procedure to reduce computational complexity of the bilateral filter that is used to estimate the illumination in our method. Since our main aim is to provide the preprocessing of text detection and recognition in natural scenes, we have proposed a simple processing in which only the signals of the dark regions in the image are enhanced. Experimental results show that our method is effective in conserving the naturalness of the image and improving the legibility of texts in natural scenes. Furthermore, by using our proposed procedure, bilateral filter computation loads can be reduced by about 30%.
Kisspeptin-10 stimulation of gonadotrophin secretion in women is modulated by sex steroid feedback (2012)

None.
A Dynamic Wireline Resource Management Scheme for Fast Handoff in Wireless ATM Networks (1999)

Introduction Wireless ATM( WATM) networks which extend ATM capability over an air interface provide broadband and multimedia services to mobile users. In particular, mobile users maintain seamless connections through hando #s when a cell boundary is crossed. Since real-time users dislike a long hando# connection time, especially with high speed connections, a fast hando# scheme is required. Conventional management schemes to support hando# at wireline access networks are classified into two approaches. These are path rerouting and path extension approaches. For a path rerouting hando# procedure a new, optimized path to a new base station (ta is established while excluding the old connection. Acampora and Naghshineh [1] proposed a virtual connection tree( CT) which consists of a root ATM switch and BS leaves. This tree requires fixed, reserved capacities between the root and the leaves, which leads to reduce utilization of the wireline link. Yu and Leung [2] proposed a source-
A Bifunctional Targeted Peptide that Blocks HER-2 Tyrosine Kinase and Disables Mitochondrial Function in HER-2-Positive Carcinoma Cells (2005)

The HER-2 oncoprotein is commonly overexpressed in a variety of human malignancies and has become an attractive antitumor target. A number of strategies to inhibit the HER-2 receptor tyrosine kinase are currently the focus of intensive preclinical and clinical research. In the present study, we have engineered a bifunctional peptide, BHAP, which consists of two modular domains: a HER-2-targeting/neutralizing domain and a mitochondriotoxic, proapoptotic domain. The chimeric peptide is biologically active and capable of selectively triggering apoptosis of HER-2-overexpressing cancer cells in culture, even those previously described as Herceptin resistant. Furthermore, BHAP slows down growth of HER-2-overexpressing human mammary xenografts established in SCID mice. This approach can be extended to the development of tailored targeted chimeric peptides against a number of overexpressed cellular receptors implicated in the development and progression of cancer.
Low-power FPGA-based display processing module for head-mounted displays (2011)

In this paper, two low-power architectures for display processing specifically for head-mounted displays are presented. The proposed solutions are implemented in an FPGA-based platform and are analyzed in terms of power consumption, area, flexibility for further improvement. The results are compared with an existing hardware solution.
Building a query log via crowdsourcing (2014)

A query log is a key asset in a commercial search engine. Everyday millions of users rely on search engines to find information on the Web by entering a few keywords on a simple search interface. Those queries represent a subset of user behavioral data which is used to mine and discover search patterns for improving the overall end user experience. While queries are very useful, it is not always possible to capture precisely what the user was looking for when the intent is not that clear. We explore a different alternative based on human computation to gather a bit more information from users and show the type of query log that would be possible to construct.
Indole Molecules As Inhibitors Of Tubulin Polymerization: Potential New Anticancer Agents (2012)

Agents that interfere with tubulin function have a broad anti-tumor spectrum and they represent one of the most significant classes of anticancer agents. In the past few years, several small synthetic molecules that have an indole nucleus as a core structure have been identified as tubulin inhibitors. Among these, several aroylindoles, arylthioindoles, diarylindoles and indolylglyoxyamides have shown good inhibition towards the tubulin polymerization. This article reviews the synthesis, biological activities and SARs of these main classes of indoles. Brief mention has also been made about the fused indole analogs as tubulin inhibitors.