gebhart/patrepeval huggingface dataset:
Lifetime and economic analyses of lithium-ion batteries for balancing wind power forecast error (2015)

Wind power plant operators are often faced with extra charges when their power production does not match the forecasted power. Because the accuracy of wind power forecasts is limited, the use of energy storage systems is an attractive alternative even when large-scale aggregation of wind power is considered. In this paper, the economic feasibility of lithium-ion batteries for balancing the wind power forecast error is analysed. In order to perform a reliable assessment, an ageing model of lithium-ion battery was developed considering both cycling and calendar life. The economic analysis considers two different energy management strategies for the storage systems and it is performed for the Danish market. Analyses have shown that the price of the Li-ion BESS needs to decrease by 6.7 times in order to obtain a positive net present value considering the present prices on the Danish energy market. Moreover, it was found that for total elimination of the wind power forecast error, it is required to have a 25-MWh Li-ion battery energy storage system for the considered 2 MW WT.
Inside Cover: Vacuum Surface Science Meets Heterogeneous Catalysis: Dehydrogenation of a Liquid Organic Hydrogen Carrier in the Liquid State (ChemPhysChem 9/2015) (2015)

On p. 1873, F. Maier et al. report that by using functionalized ionic liquids they were able to follow in situ dehydrogenation reactions at close to equilibrium conditions of real heterogeneous catalysis with ultrahigh vacuum surface science methods.
Grid-enabled adaptive surrogate modeling for computer aided engineering (2010)

A very large number of scientific and engineering fields are confronted with the need for computer simulations to study complex, real world phenomena or solve challenging design problems. However, due to the computational cost of these high fidelity simulations, the use of neural networks, kernel methods, and other surrogate modeling techniques have become indispensable. Surrogate models are compact and cheap to evaluate, and have proven very useful for tasks such as optimization, design space exploration, prototyping, and sensitivity analysis. Consequently, in many fields there is great interest in tools and techniques that facilitate the construction of such regression models, while minimizing the computational cost and maximizing model accuracy. This dissertation presents a mature, flexible, and adaptive framework for regression modeling and adaptive sampling to tackle these issues. The framework brings together algorithms for data fitting, model selection, sample selection, hyperparameter optimalization, and distributed computing in order to empower a domain expert to efficiently generate an accurate model for his/her problem.
On the effect of power and channel estimation in equalized blind PIC for downlink multirate CDMA communications (2005)

In this paper, we discuss blind parallel interference cancellation (PIC) in the downlink of W-CDMA. Due to the multirate nature of W-CDMA, different spreading factors exist. This makes the estimation of interferers' codes difficult. We propose a method based on fast Walsh transform (FWT) to estimate interfering codes. Another important aspect is the estimation of interferers' powers, which is a critical issue in any interference cancellation (IC) scheme. We propose a method based on averaging the output power of different virtual users along with their occurrence. Two receivers are considered: chip-level equalizer followed by PIC, and rake receiver followed by PIC.
Fast and Robust Motion Tracking for Time-Varying Mesh Featuring Reeb-Graph-Based Skeleton Fitting and its Application to Motion Retrieval (2007)

In this paper, an algorithm for motion extraction from time-varying mesh (TVM) is proposed. TVM is a sequence of 3D models made for real-world dynamic objects. In TVM, detailed information of 3D objects such as shape, color, and motion is stored. Therefore, TVM is an attractive technology for the next-generation multimedia. However, the management of TVM database for archiving and retrieving is a significant problem because it is difficult to locate and track feature points in TVM. For efficient and effective archive and retrieval systems, motion extraction and tracking is essential. In our approach, skeletons are extracted from TVM using Reeb graph, and motion tracking is achieved by fitting a reference skeleton to the others. We defined a geodesic function using principal component analysis (PCA) for fast and noiseless skeleton extraction. Robust fitting has been realized by an end node tracking strategy. In addition, we have developed an efficient motion retrieval system compatible to conventional motion capture (mocap) data using the extracted skeleton. As a result, low-cost query generation using mocap systems and cross search between TVM and mocap data have been achieved.
<title>Limitations of submicron holographic lithography</title> (1994)

Hologram recording geometry using total internal reflection (TIR) from a photo sensitive material surface was used to achieve 0.5 micron resolution at (lambda) equals 457 nm with a readout of reconstructed image on photoresist. Such a geometry has demonstrated stability to parallel displacement within the illuminated area, and a rotation of +/- 2 degrees. The TIR recording system provided double fringe sets for each plane component inside the volume hologram. Therefore, diffraction efficiency as high as 80% was observed. The result is applicable to high volume submicron lithography and can be expanded for an eight-inch semiconductor submicron pattern. The use of a large aperture, well collimated laser beam provides us with much higher throughput than existing lightography machines have.
Anthraquinone Liquid crystal dichroic dyes – a new form of chromonic dye? (2011)

Dichroic dyes, based on anthraquinone chromophores, for incorporation into various liquid-crystalline host mixtures have been prepared. For each dye, which has been designed to absorb at different regions of the visible spectrum, we investigate liquid crystalline behaviour and prepare mixtures of dyes that also promote liquid-crystalline behaviour. The 2,6-disubstituted dyes, which are yellow and red, respectively, exhibit nematic and smectic C phase behaviour or smectic A and E phase behaviour over wide temperature ranges. In order to produce blue dyes we report a family of dyes derived from 1,5-dihydroxy-4,8-dinitroanthraquinone, which is similar in structure to known chromonic dyes. These dyes exhibit unusual optical textures by polarised optical microscopy, and display unusual mixing behaviour, which suggests the presence of a new type of liquid crystal.
Collaborating to Compete: Blood Profiling Atlas in Cancer (BloodPAC) Consortium (2017)

The cancer community understands the value of blood profiling measurements in assessing and monitoring cancer. We describe an effort among academic, government, biotechnology, diagnostic, and pharmaceutical companies called the Blood Profiling Atlas in Cancer (BloodPAC) Project. BloodPAC will aggregate, make freely available, and harmonize for further analyses, raw datasets, relevant associated clinical data (e.g., clinical diagnosis, treatment history, and outcomes), and sample preparation and handling protocols to accelerate the development of blood profiling assays.
TriHex: Combining Formation Flying, General Circular Orbits, and Alias-Free Imaging, for High-Resolution L-Band Aperture Synthesis (2023)

The Soil Moisture and Ocean Salinity (SMOS) mission of the European Space Agency (ESA), together with NASA's Soil Moisture Active Passive (SMAP) mission, is providing a wealth of information to the user community for a wide range of applications. Although both missions are still operational, they have significantly exceeded their design life time. For this reason, ESA is looking at future mission concepts, which would adequately address the requirements of the passive L-band community beyond SMOS and SMAP. This article proposes one mission concept, TriHex, which has been found capable of achieving high spatial resolution, radiometric resolution, and accuracy, approaching the user needs. This is possible by the combination of aperture synthesis, formation flying, the use of general circular orbits, and alias-free imaging.
Distributed Port Assignment for Extraction of Power Delivery Networks (2020)

The stringent requirements of power noise on complex multi-domain power delivery networks (PDN), and the complicated relationship between signal integrity and power integrity (PI) have led to an ever challenging PI sign-off process. A lumped PDN model is widely used, where the power network is treated as a two-port network with the impedances extracted by an electromagnetic solver. A distributed model of the power network is however preferred during a PI sign-off flow, providing a more accurate circuit model for time domain simulations. Hundreds or even thousands of ports need to be properly evaluated during the PDN extraction process, which can be computationally expensive and error prone. A Python tool is described here to enable a fast and configurable process for distributed port assignment during the PDN extraction process. An enhanced automation flow, integrated with the Python tool, has also been developed to support early power network exploration. In one case study, a 360X speedup in the port assignment process is achieved while revealing a high risk power network within the package. The proposed automation flow is versatile and highly adaptive for different power network topologies.
Vascularization and innervation of slits within polydimethylsiloxane sheets in the subcutaneous space of athymic nude mice (2017)

Success of cell therapy in avascular sites will depend on providing sufficient blood supply to transplanted tissues. A popular strategy of providing blood supply is to embed cells within a functionalized hydrogel implanted within the host to stimulate neovascularization. However, hydrogel systems are not always amenable for removal post-transplantation; thus, it may be advantageous to implant a device that contains cells while also providing access to the circulation so retrieval is possible. Here we investigate one instance of providing access to a vessel network, a thin sheet with through-cut slits, and determine if it can be vascularized from autologous materials. We compared the effect of slit width on vascularization of a thin sheet following subcutaneous implantation into an animal model. Polydimethylsiloxane sheets with varying slit widths (approximately 150, 300, 500, or 1500 µm) were fabricated from three-dimensional printed molds. Subcutaneous implantation of sheets in immunodeficient mice revealed that smaller slit widths have evidence of angiogenesis and new tissue growth, while larger slit widths contain native mature tissue squeezing into the space. Our results show that engineered slit sheets may provide a simple approach to cell transplantation by providing a prevascularized and innervated environment.
System To Assess Genome Sequencing Needs for Viral Protein Diagnostics and Therapeutics (2005)

Computational analyses of genome sequences may elucidate protein signatures unique to a target pathogen. We constructed a Protein Signature Pipeline to guide the selection of short peptide sequences to serve as targets for detection and therapeutics. In silico identification of good target peptides that are conserved among strains and unique compared to other species generates a list of peptides. These peptides may be developed in the laboratory as targets of antibody, peptide, and ligand binding for detection assays and therapeutics or as targets for vaccine development. In this paper, we assess how the amount of sequence data affects our ability to identify conserved, unique protein signature candidates. To determine the amount of sequence data required to select good protein signature candidates, we have built a computationally intensive system called the Sequencing Analysis Pipeline (SAP). The SAP performs thousands of Monte Carlo simulations, each calling the Protein Signature Pipeline, to assess how the amount of sequence data for a target organism affects the ability to predict peptide signature candidates. Viral species differ substantially in the number of genomes required to predict protein signature targets. Patterns do not appear based on genome structure. There are more protein than DNA signatures due to greater intraspecific conservation at the protein than at the nucleotide level. We conclude that it is necessary to use the SAP as a dynamic system to assess the need for continued sequencing for each species individually and to update predictions with each additional genome that is sequenced.
The Hyaluronidases: A Chemical, Biological and Clinical Overview. (1996)

ヒアルロニダーゼは最近まで説明することなど必要ないと考えられていた酵素群である。これらの酵素の基質であるヒアルロナンは、徐々に重要性が増し、今や細胞の運動性、傷害治癒、発生のような基本的な過程において主要な役割を果たしており、また癌の進展にも関与していることが認められている。ヒトを悩ます下等生物においてもヒアルロニダーゼは、下等生物が侵入する際や体の中に広がっていく時に関与している、即ち細菌の有毒因子として、ガス壊その組織切開に対する病毒因子として、梅毒においてトレポネーマの広がる手段として、寄生生物ネマトーダが皮膚や内蔵へ潜り込む方法としてヒアルロニダーゼは使われている。またヒアルロニダーゼはハチ、スズメバチ、クモ、サンショウオ、ヘビ、トカゲ等多くの生物の毒液の成分でもある。これらの毒液のヒアルロニダーゼのあるものとほ乳類の精子の細胞膜に見出される酵素との間に相同性のあることは特に興味深く、酵素タンパク質の300アミノ酸の36%が保持されていることから古いタンパク質であることが分かる。明らかにヒアルロニダーゼは、多くの重要なヒトの病気の病態に関与した生物学的に興味深い酵素である。最近までなおざりにされてきたこれらの一群の酵素についてさらに研究を進めていかなくてはならない。
Development of Non-Hormonal Steroids for the Treatment of Duchenne Muscular Dystrophy (2013)

Abstract : Glucocorticoids are standard of care for Duchenne muscular dystrophy (DMD) patients. The rationale to use glucocorticoids in DMD patients is largely empirical and the molecular mechanisms that help to improve muscle strength in DMD patients are unknown. Despite the success of glucocorticoids in increasing strength, their prescription in DMD remains controversial partly due to significant side effects associated with chronic glucocorticoid use in these patients. It has been proposed that side effects (e.g. metabolic) of glucocorticoids are due to transcriptional activation while beneficial effects (e.g. antiinflammatory) are due to transrepression indicating that designing selective glucocorticoid receptor (GR) ligands may maintain beneficial effects while reducing metabolic side effects (Coghlan et al., 2003). In collaboration with Validus Biopharma, we have developed glucocorticoid analogues (referred as VBP compounds) that retain the beneficial effects but not the side effects. We have previously shown that these compounds are potent NF B inhibitors and chronic in vivo administration of these compounds improves skeletal muscle function and histology in the mdx mouse model of DMD, yet reduce side effects commonly associated with existing glucocorticoids. After extensive screening and testing we have identified a lead candidate, VBP15, and preliminary data presented here characterizes the promising ADME and initial safety studies performed to date. Objective/Hypothesis: The objective of this proposal is to characterize the in vitro safety of VBP15 in human hepatocytes, and in vivo non-GLP acute toxicity and GLP 28-day repeated dose toxicity of VBP15 in rat and dog. This data will be used for an investigational new drug (IND) application to the FDA for use of VBP15 in muscular dystrophy. Specific Aims: In this proposal we will perform pre-IND in vitro safety (CYP induction assays in human hepatocytes) and in vivo toxicity studies.
On the propagation of faults and their detection in a hardware implementation of the Advanced Encryption Standard (2003)

High reliability is a desirable property of any implementation of the Advanced Encryption Standard (AES). To achieve high reliability, all possible faults must be detected to avoid the use and transmission of erroneous encrypted/decrypted data. In this paper we first study the behavior of faults which may occur during the encryption and decryption procedures of AES, and the way such faults eventually propagate to the final result. We then describe an appropriate detection technique for these faults. This work extends our preliminary results (G. Bertoni et al, MPCS 2002) by considering more general fault models (e.g., permanent and multiple transient faults), and the possibility of fault masking.
Efficiency of Prostate Cancer Diagnosis by MR/Ultrasound Fusion-Guided Biopsy vs Standard Extended-Sextant Biopsy for MR-Visible Lesions (2016)

In men with MR-visible prostate lesions, targeted biopsy is more efficient than standard biopsy, diagnosing a similar number of cancer cases and more high-grade cases while sampling 56.1% fewer biopsy cores.
Predictors of Survival for Patients with Acute Decompensated Heart Failure Requiring Extra-Corporeal Membrane Oxygenation Therapy (2018)

Chronic systolic heart failure (HF) with acute decompensation can result in cardiogenic shock (CS) requiring short-term mechanical circulatory support. We sought to identify predictors of survival for acute decompensated HF (ADHF) patients requiring veno-arterial extracorporeal membrane oxygenation (VA-ECMO). Patients >18 years old treated at our institution with VA-ECMO from 2009 to 2018 for ADHF with CS were studied. Demographic, hemodynamic, and echocardiographic data were collected. The primary outcome was survival to discharge. Fifty-two patients received VA-ECMO for ADHF with CS; 24 (46.2%) survived. Seventeen (32.7%) had suffered cardiac arrest, and 37 (71.2%) were mechanically ventilated. Mean lactate was 4.33 ± 3.45 mmol/L, and patients were receiving 2.7 ± 1.2 vasopressor/inotropic infusions at ECMO initiation; these did not differ significantly between survivors and nonsurvivors. Pre-ECMO cardiac index was 1.84 ± 0.56L/min/m and 1.94 ± 0.63L/min/m in survivors and nonsurvivors, respectively (p = 0.57). In multivariable analysis, only diabetes mellitus (DM; OR, 13.25; CI, 1.42-123.40; p = 0.02) and mineralocorticoid receptor antagonist use (OR, 0.12; CI, 0.02-0.78; p = 0.03) were independent predictors of mortality. Nineteen (79.2%) survivors required durable ventricular assist device. Among ADHF patients receiving VA-ECMO, DM is a powerful predictor of outcomes while markers of clinical acuity including hemodynamics, vasopressor/inotrope use, and lactate are not. The vast majority of survivors required durable left-ventricular assist devices.
Core Replacements in a Potent Series of VEGFR-2 Inhibitors and Their Impact on Potency, Solubility, and hERG (2016)

Anti-VEGF therapy has been a clinically validated treatment of age-related macular degeneration (AMD). We have recently reported the discovery of indole based oral VEGFR-2 inhibitors that provide sustained ocular retention and efficacy in models of wet-AMD. We disclose herein the synthesis and the biological evaluation of a series of novel core replacements as an expansion of the reported indole based VEGFR-2 inhibitor series. Addition of heteroatoms to the existing core and/or rearranging the heteroatoms around the 6-5 bicyclic ring structure produced a series of compounds that generally retained good on-target potency and an improved solubility profile. The hERG affinity was proven not be dependent on the change in lipophilicity through alteration of the core structure. A serendipitous discovery led to the identification of a new indole-pyrimidine connectivity: from 5-hydroxy to 6-hydroxyindole with potentially vast implication on the in vitro/in vivo properties of this class of compounds.
Who remembers best? Individual differences in memory for events that occurred in a science museum (1992)

Abstract Individual differences in memory and suggestibility were assessed in an experiment involving 1989 people who attended the Exploratorium, a science museum located in San Francisco. Subjects watched a brief film clip of an assault and later answered questions about it. Approximately half received misinformation about some critical items. Four demographic variables (gender, educational level, age, and occupation) were examined to determine their impact on memory performance. The principle of discrepancy detection predicts that, compared to individuals with a good memory, people who have poor memory to begin with will be relatively suggestible (that is susceptible to misinformation). Some of our findings were consistent with this principle. For example, children (5–10 years) and elderly (over 65) were relatively inaccurate and also relatively suggestible. Other findings were not consistent with the principle, for example the finding that artists and architects were relatively accurate, but they were also highly suggestible.
N-type thin-film polycrystalline-silicon solar cells using a seed layer approach (2009)

N-type thin-film polycrystalline-silicon solar cells were fabricated on alumina substrates. The polycrystalline silicon material was made by overdoping of AIC seed layers with phosphorus atoms followed by epitaxial thickening with low-pressure chemical vapor deposition (LPCVD) at 1000°C. The cells have i/p+ amorphous Si heterojunction emitters and show an average V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">OC</sub> of 455 mV, an average J <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">SC</sub> of 16.5 mA cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> and a record efficiency of 5.0%. The excess out-diffusion of phosphorus from the seed layers during the epitaxial growth resulted in a non-ideal doping profile, which is believed to be the main limitation of the current density besides the material quality. In addition, the non-optimized heterojunction emitter deposition for n-type polycrystalline silicon and the lack of superior light trapping also limited the present cell performance.
Supplementary Tables 1 - 3, Figures 1 - 7 from An Antibody–Drug Conjugate That Targets Tissue Factor Exhibits Potent Therapeutic Activity against a Broad Range of Solid Tumors (2023)

&lt;p&gt;PDF file - 166K, Supplementary Table S1: TF HuMab: target binding characteristics and inhibition of FXa generation. Supplementary Table S2: Cross-competition between TF HuMab. Supplementary Table S3: Thromboelastography: coagulation of LPS-stimulated whole blood in the presence of 20 microg/mL TF-011, TF-013 or TF-098. Supplementary Figure S1: TF HuMab inhibit TF:FVIIa-induced ERK1/2 phosphorylation. Supplementary Figure S2: TF:FVIIa-induced IL-8 production in MDA-MB-231 cells is reduced in the presence of TF HuMab. Supplementary Figure S3: Binding of TF HuMab is unaltered after conjugation with vcMMAE or mcMMAF. Supplementary Figure S4: Anti-tumor activity of TF-ADCs in the A431 and HCT-116 xenograft models. Supplementary Figure S5: Anti-tumor activity of unconjugated TF HuMab in vivo. Supplementary Figure S6: Post-paclitaxel treatment with TF-011-MMAE in PDX models. Supplementary Figure S7: Full-length blots for Figure 1C.&lt;/p&gt;
Tumor mutational burden predicts the efficacy of pembrolizumab monotherapy: a pan-tumor retrospective analysis of participants with advanced solid tumors (2022)

TMB ≥175 mutations/exome is associated with clinically meaningful improvement in the efficacy of pembrolizumab monotherapy and improved outcomes for pembrolizumab versus chemotherapy across a wide range of previously treated advanced solid tumor types. These data suggest TMB has broad clinical utility irrespective of tumor type, PD-L1 expression, or MSI status and support its use as a predictive biomarker for pembrolizumab monotherapy in participants with previously treated advanced solid tumors.
Pattern Recognition with Supplementary Information (2007)

パターン認識とは，一般にパターンから得られる特徴量を用いて，そのパターンをクラスの一つに対応づける処理である．ベイズ誤りとしてよく知られているように，この枠組みには原理的な限界がある．すなわち，一般にはひずみ等によりパターンの特徴量はある分布をなして広がっており，その結果，2 クラスの分布にはオーバラップする範囲が存在する．この範囲に属するパターンは本質的にあいまいなものであり，その正しい認識は不可能である．こうした限界のもと，オーバラップがなるべく少なくなるような特徴，すなわち高い認識率が得られるような特徴の抽出が検討されてきた．その努力により実用的な精度をもつ認識器が多く開発されている．しかしながら，それらの認識対象はひずみが少ないなど，条件の良いものに限定されていることが多い．例えば市販OCR の対象は手書き文字ではなく活字が中心である．また，識別に有効な特徴量は必ずしも自明でなく，