gebhart/patrepeval huggingface dataset:
Dynamic and multiplexed networks for working memory. (2017)

Working memory (WM) provides the neurobiological infrastructure for human cognition. Dominant models positthat prefrontal cortex (PFC) supports WM by coordinating control over distributed memory representations. In two studies,multimodal electrophysiology data reveal that PFC control over WM is rhythmic, fundamentally dynamic, and not altogethernecessary. Direct brain recordings (n=10) demonstrate that PFC and medial temporal lobe (MTL) theta-band rhythms directa complex system of higher-frequency neural activity across regions, uncovering initial support for bidirectional PFC-MTLinteractions related to WM demands. Then, data from patients with unilateral PFC damage (n=14) challenge dominant modelson the central role of PFC (note 8% accuracy decrease in patients). In healthy controls (n=20), delta-theta-band rhythms precessfrom PFC toward parieto-occipital sites, concurrent with alpha-beta-band rhythms precessing in the opposite direction. All PFCeffects are diminished with unilateral damage, revealing an independent posterior WM mechanism. These results reveal thatrapid, parallel processing governs WM.
Application of second-order statistics for an indoor radio channel model (2003)

The secondary statistics for an indoor radio impulse response model in the factory environment are investigated. Under the assumption that multipath signal amplitudes are jointly log-normally distributed over local areas and excess delay, the application of second-order statistics (correlation) is presented. In addition, the distributions of received power within a particular excess delay interval are found for both global and local areas. It is shown that the log-normal distribution describes the fading of multipath components over local areas for particular excess delays. Moreover, individual multipath signal strengths are log-normal about a mean power law of the form d/sup n/. The log-normal distribution is attractive for modeling the impulse response amplitudes because correlation data are easily incorporated. Conditional probabilities of path occupancy are presented which show the effect power control will have on indoor radio systems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Metabolomic Analysis Identifies Alterations of Amino Acid Metabolome Signatures in the Postmortem Brain of Alzheimer's Disease (2019)

Despite significant advances in neuroscience research over the past several decades, the exact cause of AD has not yet fully understood. The metabolic hypothesis as well as the amyloid and tau hypotheses have been proposed to be associated with AD pathogenesis. In order to identify metabolome signatures from the postmortem brains of sporadic AD patients and control subjects, we performed ultra performance liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometer (UPLC-LTQ-Orbitrap-MS). Not only our study identified new metabolome signatures but also verified previously known metabolome profiles in the brain. Statistical modeling of the analytical data and validation of the structural assignments discovered metabolic biomarkers associated with the AD pathogenesis. Interestingly, hypotaurin, myo-inositol and oxo-proline levels were markedly elevated in AD while lutamate and N-acetyl-aspartate were decreased in the postmortem brain tissue of AD patients. In addition, neurosteroid level such as cortisol was significantly increased in AD. Together, our data indicate that impaired amino acid metabolism is associated with AD pathogenesis and the altered amino acid signatures can be useful diagnostic biomarkers of AD. Thus, modulation of amino acid metabolism may be a possible therapeutic approach to treat AD.
Sleep Modes for Enhanced Battery Life of 5G Mobile Terminals (2016)

In addition to higher data rates and lower latency the 5G Radio Access Technology concepts are targeting to provide better battery life for mobile broadband and Machine Type Communication users. In this overview paper we analyze how microsleep, Discontinuous Reception and Transmission, and a wake-up receiver concept can be combined to enhance the battery life of 5G mobile terminals. Due to the short and pipelined 5G frame structure microsleep provides 20 % energy savings as compared to LTE. The Discontinuous Reception and Transmission modes also benefit from the new frame structure leading to faster connection setup and up to 80 % lower energy consumption depending on the traffic type. Finally we estimate that the wake-up receiver concept, when adapted to scheduled and cellular communication, can provide 90 % lower energy consumption and ensure a predictable and consistent latency.
A girl with a neurodevelopmental syndrome, adducted thumbs and frequent infections caused by novel homozygous variant in DEAF1 (2020)

Sumathipala, Dulika S.a,,*; Misceo, Dorianaa,,*; Larsen, Selma Mujezinovicb; Barøy, Tuvaa; Gamage, Thilini H.a; Frengen, Eirika; Strømme, Petterb,,c Author Information
High-dynamic-range 4-Mpixel CMOS image sensor for scientific applications (2012)

As bio-technology transitions from research and development to high volume production, dramatic improvements in image sensor performance will be required to support the throughput and cost requirements of this market. This includes higher resolution, higher frame rates, higher quantum efficiencies, increased system integration, lower read-noise, and lower device costs. We present the performance of a recently developed low noise 2048(H) x 2048(V) CMOS image sensor optimized for scientific applications such as life science imaging, microscopy, as well as industrial inspection applications. The sensor architecture consists of two identical halves which can be operated independently and the imaging array consists of 4T pixels with pinned photodiodes on a 6.5&#956;m pitch with integrated micro-lens. The operation of the sensor is programmable through a SPI interface. The measured peak quantum efficiency of the sensor is 73% at 600nm, and the read noise is about 1.1e- RMS at 100 fps data rate. The sensor features dual gain column parallel ouput amplifiers with 11-bit single slope ADCs. The full well capacity is greater than 36ke-, the dark current is less than 7pA/cm<sup>2</sup> at 20&deg;C. The sensor achieves an intra-scene linear dynamic range of greater than 91dB (36000:1) at room temperature.
Ex Situ and Operando XRD and XAS Analysis of MoS2: A Lithiation Study of Bulk and Nanosheet Materials (2019)

Molybdenum(IV) sulfide (MoS2) has generated significant interest as an electroactive material for Li-ion batteries because of its high theoretical capacity, good rate capability, and minimal volume changes during cycling. An important challenge toward implementing this material is understanding the many polymorphs of MoS2 that can be (de)stabilized by electrochemical lithiation and nanosizing. To this end, bulk MoS2 and nanosheet-type MoS2 were characterized both as solids (X-ray diffraction (XRD), X-ray absorption spectroscopy (XAS), X-ray photoelectron spectroscopy (XPS), and inductively coupled plasma-optical emission spectroscopy (ICP-OES)) and during electrochemical cycling within operando X-ray analysis compatible lithium cells (operando XRD and ex situ XAS). In situ XRD shows that the bulk 2H-MoS2 phase is converted to 1T-LixMoS2 upon discharge and that this change is only partially reversible upon charge. Furthermore, operando XRD identifies the nanosheet MoS2 as the metastable 1T′ phase and shows that this phase is conserved upon discharge. Ex situ XAS provides additional structural insights into the local structure of MoS2, confirming that the 1T′ phase is the correct assignment of the nanosheet MoS2 and revealing an irreversible local distortion that occurs during cycling. This local distortion is likely a factor in the increased capacity fade observed in the nanosheet cells. This work provides important insights into the structure of MoS2 and how that structure is affected by nanosizing and cycling, which can inform other studies of nanosheet layered materials.
ChemInform Abstract: Leishmania Cell Wall as a Potent Target for Antiparasitic Drugs. A Focus on the Glycoconjugates (2015)

Abstract Review: 115 refs.
On scalable lossless video coding based on sub-pixel accurate MCTF (2006)

We propose two approaches to scalable lossless coding of motion video. They achieve SNR-scalable bitstream up to lossless reconstruction based upon the subpixel-accurate MCTF-based wavelet video coding. The first approach is based upon a two-stage encoding strategy where a lossy reconstruction layer is augmented by a following residual layer in order to obtain (nearly) lossless reconstruction. The key advantages of our approach include an 'on-the-fly' determination of bit budget distribution between the lossy and the residual layers, freedom to use almost any progressive lossy video coding scheme as the first layer and an added feature of near-lossless compression. The second approach capitalizes on the fact that we can maintain the invertibility of MCTF with an arbitrary sub-pixel accuracy even in the presence of an extra truncation step for lossless reconstruction thanks to the lifting implementation. Experimental results show that the proposed schemes achieve compression ratios not obtainable by intra-frame coders such as Motion JPEG-2000 thanks to their inter-frame coding nature. Also they are shown to outperform the state-of-the-art non-scalable inter-frame coder H.264 (JM) lossless mode, with the added benefit of bitstream embeddedness.
Synthesis of Novel 8-Hydroxyquinoline-Containing Diaz-18-Crown-6 Ligands and Analogues. (1999)

Abstract : Ten new analogues of 5-chloro-8-hydroxyquinolin-7-ylmethyl-and -5-chloro-8-hydroxyquinolin-2-ylmethyl-substituted diaza-18-crown-6 ethers 1 and 2, respectively (Figure 1) were synthesized via a one-pot or stepwise Mannich reaction, reductive amination, or by reacting diaza-18-crown-6 with 5,7-dichloro-2-iodomethyl-8-quinolinol in the presence of N,N-diisopropylethylamine (Schemes 1 and 2). The Mannich reaction of N,N'- bis(methozymethyl)diaza-18-crown-6 with 4-chloro-2-(1 H-pyrazol-3-yl)phenol gave the - NCH2N-linked bis(3-(5-chloro-2-hydroxy)pyrazol-1-ylmethyl)-substituted diazacrown ether (14) in a 98% yield. The reaction of bis-N,N'-methoxymethyldiaza-18-crown-6 with 2.2 equivalents of 10-hydroxybenzoquinoline gave only the monosubstituted diazacrown ether ligand (8). The yields of the new products are given in the schemes.
A United Framework for Video Browsing and Retrieval (2000)

Research on how to efficiently access video content has become increasingly active in the past few years. Considerable progress has been made in video analysis, representation, browsing, and retrieval, which are the four fundamental bases for accessing video content. Video analysis deals with the signal processing part of the video system, including shot boundary detection, key frame extraction, etc. Video representation is concerned with the structure of the video. An example of a video representation is the tree structured key frame hierarchy. Built on top of the video representation, video browsing deals with how to use the representation structure to help viewers browse the video content. Finally, video retrieval is concerned with retrieving interesting video objects.
Peroxisome proliferator-activated receptor δ promotes very low-density lipoprotein-derived fatty acid catabolism in the macrophage (2006)

Significant attention has focused on the role of low-density lipoprotein (LDL) in the pathogenesis of atherosclerosis. However, recent advances have identified triglyceride-rich lipoproteins [e.g., very LDL (VLDL)] as independent risk predictors for this disease. We have previously demonstrated peroxisome proliferator-activated receptor (PPAR)delta, but not PPARgamma, is the major nuclear VLDL sensor in the macrophage, which is a crucial component of the atherosclerotic lesion. Here, we show that, in addition to beta-oxidation and energy dissipation, activation of PPARdelta by VLDL particles induces key genes involved in carnitine biosynthesis and lipid mobilization mediated by a recently identified TG lipase, transport secretion protein 2 (also named desnutrin, iPLA2zeta, and adipose triglyceride lipase), resulting in increased fatty acid catabolism. Unexpectedly, deletion of PPARdelta results in derepression of target gene expression, a phenotype similar to that of ligand activation, suggesting that unliganded PPARdelta suppresses fatty acid utilization through active repression, which is reversed upon ligand binding. This unique transcriptional mechanism assures a tight control of the homeostasis of VLDL-derived fatty acid and provides a therapeutic target for other lipid-related disorders, including dyslipidemia and diabetes, in addition to coronary artery disease.
3D Wafer-to-Wafer Bonding Thermal Resistance Comparison: Hybrid Cu/dielectric Bonding versus Dielectric via-last Bonding (2020)

3D wafer-to-wafer bonding is a promising fabrication method to create 3D systems with a very high interconnect density. The thermal resistance of the 3D bonding interface can represent a significant contribution of the overall thermal resistance in the 3D chip stack and should therefore be accurately characterized. In this paper, we present the experimental characterization of two different types of 3D wafer-to-wafer bonding: Cu/dielectric hybrid bonding and via-last dielectric bonding. First, we introduce the wafer-level test vehicles and the characterization methodology for the analysis of both bonding interfaces. Then, we estimate the thermal resistance of the bonding interface based on a combination of temperature measurements and finite element thermal simulations. Benchmarking of the measurement results with available literature data on thermal resistance values of 3D interfaces shows that wafer-to-wafer bonding results in a reduction of the bonding layer thermal resistance of 5x and 20x for the hybrid bonding and dielectric bonding respectively, compared to the standard die-to-wafer bonding approach with micro-bumps and underfill.
Private Peer-to-Peer Overlay for Real-Time Monitoring of a Deployed Internet-Scale Peer-to-Peer Overlay (2007)

Peer-to-peer system decentralization complicates performance monitoring-and real-time monitoring is particularly challenging. We discuss our experience with monitoring the Peer Name Resolution Protocol (PNRP), a peer-to-peer name resolution/routing protocol and overlay deployed over the Internet. We must collect accurate performance data without adding traffic overhead. Unfortunately, no central node has sufficient monitoring information, and scalability and privacy concerns make it impractical to collect reliable real-time data from active client nodes. Our method obtains information from lightweight nodes (Weather Stations) actively deployed on the P2P network and themselves forming a private P2P overlay. We monitor the overall performance of the PNRP protocol on the Internet and produce timely reports supporting network management, security alerting, and system maintenance.
Temporal HLA Profiling and Immunomodulatory Effects of Human Adult Bone Marrow- and Adipose-Derived Mesenchymal Stem Cells (2013)

These findings provide insight regarding the relationship between MSC passage number and MSC immunosuppressive properties and suggest that AMSCs hold advantages over BMSCs for immunomodulatory therapeutic purposes.
Predicting human interruptibility with sensors (2005)

A person seeking another person's attention is normally able to quickly assess how interruptible the other person currently is. Such assessments allow behavior that we consider natural, socially appropriate, or simply polite. This is in sharp contrast to current computer and communication systems, which are largely unaware of the social situations surrounding their usage and the impact that their actions have on these situations. If systems could model human interruptibility, they could use this information to negotiate interruptions at appropriate times, thus improving human computer interaction.This article presents a series of studies that quantitatively demonstrate that simple sensors can support the construction of models that estimate human interruptibility as well as people do. These models can be constructed without using complex sensors, such as vision-based techniques, and therefore their use in everyday office environments is both practical and affordable. Although currently based on a demographically limited sample, our results indicate a substantial opportunity for future research to validate these results over larger groups of office workers. Our results also motivate the development of systems that use these models to negotiate interruptions at socially appropriate times.
Biodegradable Cell-Seeded Nanofiber Scaffolds for Neural Repair (2011)

Central and peripheral neural injuries are traumatic and can lead to loss of motor and sensory function, chronic pain, and permanent disability. Strategies that bridge the site of injury and allow axonal regeneration promise to have a large impact on restoring quality of life for these patients. Engineered materials can be used to guide axonal growth. Specifically, nanofiber structures can mimic the natural extracellular matrix, and aligned nanofibers have been shown to direct neurite outgrowth and support axon regeneration. In addition, cell-seeded scaffolds can assist in the remyelination of the regenerating axons. The electrospinning process allows control over fiber diameter, alignment, porosity, and morphology. Biodegradable polymers have been electrospun and their use in tissue engineering has been demonstrated. This paper discusses aspects of electrospun biodegradable nanofibers for neural regeneration, how fiber alignment affects cell alignment, and how cell-seeded scaffolds can increase the effectiveness of such implants.
Low chirp electro-optic intensity modulation using planar microwave 180-degree hybrid directly prepared on LiNbO<inf>3</inf> substrate (2014)

An electro-optic (EO) modulator integrated with the microwave planar circuit directly prepared onto a LiNbO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> substrate for low chirp performance and compact configuration is introduced. A microwave rat-race (RR) circuit, which operates as the 180-degree hybrid, is designed on a z-cut LiNbO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> substrate to create two modulation signals of the same amplitude in antiphase with each other from a single-input signal. Output ports of the RR were connected to the modulation electrodes on the substrate. The two signals drive two phase modulation parts of dual-electrode Mach-Zehnder modulator so that the symmetric interference are realized to obtain low-chirp intensity modulated light signals. The modulator was designed and fabricated for around 10 GHz modulation frequencies and 1550 nm light wavelength. The chirp parameters were measured to be less than 0.2 in the frequency range between 8 and 12 GHz. By compensating the unbalance of the light power splitting the chirp could be significantly reduced.
Remplissage Versus Modified Latarjet for Off-Track Hill-Sachs Lesions With Subcritical Glenoid Bone Loss (2018)

For off-track Hill-Sachs lesions with subcritical glenoid bone loss, both the remplissage and modified Latarjet can achieve satisfactory results with the initial surgical intervention in the general population, but a higher complication rate was observed in the Latarjet group. However, Latarjet appears to be a better choice in patients with revision instability surgery, collision and contact athletes, and those with >10% glenoid bone loss.
YbeY, a Heat Shock Protein Involved in Translation in Escherichia coli (2009)

Here we provide evidence that YbeY, a conserved heat shock protein with unknown function, is involved in the translation process. ybeY deletion mutants are temperature sensitive and have a significantly reduced thermotolerance. Nonetheless, there appears to be no damage of the protein quality control of mature polypeptides, as the levels of chaperones and proteases are normal and there is no accumulation of aggregates. Rather, the mutation results in a significant reduction in the level of polysomes, and upon a shift to a restrictive temperature (42 degrees C), there is an immediate and severe slowdown of translation. Taken together, the data indicate that YbeY is an important factor for bacterial translation even at 37 degrees C but becomes essential at high temperatures.
Seismic structure of the crust and uppermost mantle in the incipient stage of back arc rifting — northernmost Okinawa Trough (2004)

In 1999, a marine seismic structure survey was conducted in the northernmost Okinawa Trough. Outcrops of the acoustic basement through the sedimentary layers are seen in the obtained structures. Velocities of lower layer in upper crust are varying laterally from 5.7 to 6.2 km/s and thickness of 6.0‐km/s layer ranges from 3 to 9 km. The lower crust has uniform thickness of about 15 km. The Pn velocity is 7.7–7.8 km/s and the total crustal thickness is about 25 km including sedimentary layers. The structure is in a first approximation similar to that of island arcs. However, the large heterogeneity of upper crust can be interpreted as a result of crustal thinning. The low Pn velocity and the outcrops of the acoustic basement relate to igneous activity in this area. These results suggest that the northernmost part of the Okinawa Trough is in the incipient stage of a back arc rifting.
Long-term follow-up of patients with CLL treated with the selective Bruton's tyrosine kinase inhibitor ONO/GS-4059. (2017)

[First paragraph] The inhibitor of Bruton’s tyrosine kinase (BTK) ibrutinib has transformed the treatment of chronic lymphocytic leukemia (CLL); many patients with previously untreatable disease may now enter durable remissions.1,2 Nevertheless, the kinome of ibrutinib is broad, resulting in toxicities including bleeding, arthralgia, diarrhea, hypertension, and atrial fibrillation.3-6 Up to 20% of patients discontinue ibrutinib due to toxicity.7-9 More selective BTK inhibitors (BTKis) include ONO/GS-4059, acalabrutinib, and BGB-3111. Preliminary data indicate that these drugs have comparable activity to ibrutinib, but with reduced toxicities.10-12 However, long-term follow-up and response data have not yet been reported. We provide an updated, 3-year follow-up of treatment efficacy, safety, and laboratory correlates, including baseline mutational profiling of CLL patients in the phase 1 ONO/GS-4059 extension study.
Rapid Selective Electrocatalytic Reduction of Carbon Dioxide to Formate by an Iridium Pincer Catalyst Immobilized on Carbon Nanotube Electrodes (2014)

An iridium pincer dihydride catalyst was immobilized on carbon nanotube-coated gas diffusion electrodes (GDEs) by using a non-covalent binding strategy. The as-prepared GDEs are efficient, selective, durable, gas permeable electrodes for electrocatalytic reduction of CO2 to formate. High turnover numbers (ca. 54,000) and turnover frequencies (ca. 15 s(-1)) were enabled by the novel electrode architecture in aqueous solutions saturated in CO2 with added HCO3(-).