gebhart/patrepeval huggingface dataset:
Bone marrow deficiency of mRNA decaying protein Tristetraprolin increases inflammation and mitochondrial ROS but reduces hepatic lipoprotein production in LDLR knockout mice (2020)

Tristetraprolin (TTP), an mRNA binding and decaying protein, plays a significant role in controlling inflammation by decaying mRNAs encoding inflammatory cytokines such as TNFalpha. We aimed to test a hypothesis that TTP in bone marrow (BM) cells regulates atherogenesis by modulating inflammation and lipid metabolism through the modulation of oxidative stress pathways by TTP target genes. In a BM transplantation study, lethally irradiated atherogenic LDLR<sup>-/-</sup> mice were reconstituted with BM cells from either wild type (TTP<sup>+/+</sup>) or TTP knockout (TTP<sup>-/-</sup>) mice, and fed a Western diet for 12 weeks. We made the following observations: (1) TTP<sup>-/-</sup> BM recipients display a significantly higher systemic and multi-organ inflammation than TTP<sup>+/+</sup> BM recipients; (2) BM TTP deficiency modulates hepatic expression of genes, detected by microarray, involved in lipid metabolism, inflammatory responses, and oxidative stress; (3) TTP<sup>-/-</sup> BM derived macrophages increase production of mitochondrial reactive oxygen species (mtROS); (4) BM-TTP<sup>-/-</sup> mice display a significant reduction in serum VLDL/LDL levels, and attenuated hepatic steatosis compared to controls; and (5) Reduction of serum VLDL/LDL levels offsets the increased inflammation, resulting in no changes in atherosclerosis. These findings provide a novel mechanistic insight into the roles of TTP-mediated mRNA decay in bone marrow-derived cells in regulating systemic inflammation, oxidative stress, and liver VLDL/LDL biogenesis.
Supine Position is Safe and Effective for Percutaneous Nephrolithotomy (2005)

No AccessJournal of UrologyUrological Survey: Urolithiasis, Endourology and Laparoscopy1 Aug 2005Supine Position is Safe and Effective for Percutaneous Nephrolithotomy Ralph V. ClaymanM.D. Ralph V. ClaymanRalph V. Clayman More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)68327-7AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Supine Position is Safe and Effective for Percutaneous Nephrolithotomy." The Journal of Urology, 174(2), pp. 601–602 References 1 : Technique and complications of percutaneous nephroscopy: experience with 557 patients in the supine position. J Urol1998; 160: 1975. Google Scholar © 2005 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited BySofer M, Giusti G, Proietti S, Mintz I, Kabha M, Matzkin H and Aviram G (2018) Upper Calyx Approachability through a Lower Calyx Access for Prone Versus Supine Percutaneous NephrolithotomyJournal of Urology, VOL. 195, NO. 2, (377-382), Online publication date: 1-Feb-2016.Neto E, Mitre A, Gomes C, Arap M and Srougi M (2018) Percutaneous Nephrolithotripsy With the Patient in a Modified Supine PositionJournal of Urology, VOL. 178, NO. 1, (165-168), Online publication date: 1-Jul-2007. Volume 174Issue 2August 2005Page: 601-602 Advertisement Copyright & Permissions© 2005 by American Urological Association, Inc.MetricsAuthor Information Ralph V. Clayman More articles by this author Expand All Advertisement Loading ...
The class-E concept for efficient wide-band coupling-insensitive transdermal power and data transfer (1992)

This paper presents an innovative method for the transcutaneous transmission of RF power and digital data via an inductive link. The system is based on the single ended class-E power amplification scheme. A self oscillating class-E tuned power amplifier involving an inductive link permits high-efficiency coupling-insensitive power transmission. The oscillation frequency is not fixed but influenced by the coupling of the coils. Due to the excellent switching characteristics of the oscillator, Amplitude Shift Keying (ASK) may be employed for digital data transmission. Data decoding can easily be achieved by envelope detection. The realization of the system requires a small number of circuit components. It is employed for the transcutaneous transmission of digital data and power in a Cochlear Prosthesis system.
Fluorescence study of aluminosilicate sols and gels doped with hydroxy trisulfonated pyrene (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFluorescence study of aluminosilicate sols and gels doped with hydroxy trisulfonated pyreneJ. C. Pouxviel, B. Dunn, and J. I. ZinkCite this: J. Phys. Chem. 1989, 93, 5, 2134–2139Publication Date (Print):March 1, 1989Publication History Published online1 May 2002Published inissue 1 March 1989https://pubs.acs.org/doi/10.1021/j100342a082https://doi.org/10.1021/j100342a082research-articleACS PublicationsRequest reuse permissionsArticle Views284Altmetric-Citations160LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Thermal Stability of π-Conjugated n-Ethylene-Glycol-Terminated Quaterthiophene Oligomers: A Computational and Experimental Study (2020)

This work represents a joint computational and experimental study on a series of <i>n</i>-ethylene glycol (PEO<i>n</i>)-terminated quaterthiophene (4T) oligomers for 1 < <i>n</i> < 10 to elucidate their self-assembly behavior into a smectic-like lamellar phase. This study builds on an earlier study for <i>n</i> = 4 that showed that our model predictions were consistent with experimental data on the melting behavior and structure of the lamellar phase, with the latter consisting of crystal-like 4T domains and liquid-like PEO4 domains. The present study aims to understand how the length of the terminal PEO<i>n</i> chains modulates the disordering temperature of the lamellar phase and hence the relative stability of the ordered structure. A simplified bilayer model, where the 4T domains are not explicitly described, is put forward to efficiently estimate the disordering effect of the PEO domains with increasing <i>n</i>; this method is first validated by correctly predicting that layers of alkyl (PE)-capped 4T oligomers (for 1 < <i>n</i> < 10) stay ordered at room temperature. Both 4T-domain implicit and explicit model simulations reveal that the order-disorder temperature decreases with the length of the PEO capping chains, as the associated increase in conformational entropy drives a tendency toward disorder that overtakes the cohesive energy, keeping the ordered packing of the 4T domains.
Structures of human Malic Enzyme 3 (2022)

Summary Malic enzymes (ME1, ME2, and ME3) are involved in cellular energy regulation, redox homeostasis, and biosynthetic processes, through the production of pyruvate and reducing agent NAD(P)H. Recent studies have implicated the third and least well-characterized isoform, mitochondrial NADP + -dependent malic enzyme 3 (ME3), as a therapeutic target for pancreatic cancers. Here, we utilized an integrated structure approach to capture the structures of ME3 in various ligand binding states. ME3 exists as a stable tetramer and its dynamic Domain C is critical for activity. Catalytic assay results reveal that ME3 is a non-allosteric enzyme and does not require modulators for activity while structural analysis suggests that the inner stability of ME3 domain A relative to ME2 disables allostery in ME3. With structural information available for all three malic enzymes, the foundation has been laid to understand the structural and biochemical differences of these enzymes and could aid in the development of specific malic enzyme small molecule drugs.
Data from RETRACTED: Methylation Mediated Silencing of MicroRNA-1 Gene and Its Role in Hepatocellular Carcinogenesis (2023)

&lt;div&gt;Abstract&lt;p&gt;MicroRNAs (miR) are a class of small (∼21 nucleotide) noncoding RNAs that, in general, negatively regulate gene expression. Some miRs harboring CGIs undergo methylation-mediated silencing, a characteristic of many tumor suppressor genes. To identify such miRs in liver cancer, the miRNA expression profile was analyzed in hepatocellular carcinoma (HCC) cell lines treated with 5-azacytidine (DNA hypomethylating agent) and/or trichostatin A (histone deacetylase inhibitor). The results showed that these epigenetic drugs differentially regulate expression of a few miRs, particularly &lt;i&gt;miR-1-1&lt;/i&gt;, in HCC cells. The CGI spanning exon 1 and intron 1 of &lt;i&gt;miR-1-1&lt;/i&gt; was methylated in HCC cell lines and in primary human HCCs but not in matching liver tissues. The &lt;i&gt;miR-1-1&lt;/i&gt; gene was hypomethylated and activated in &lt;i&gt;DNMT1&lt;/i&gt;−/− HCT 116 cells but not in DNMT3B &lt;i&gt;null&lt;/i&gt; cells, indicating a key role for DNMT1 in its methylation. miR-1 expression was also markedly reduced in primary human hepatocellular carcinomas compared with matching normal liver tissues. Ectopic expression of miR-1 in HCC cells inhibited cell growth and reduced replication potential and clonogenic survival. The expression of FoxP1 and MET harboring three and two miR-1 cognate sites, respectively, in their respective 3′-untranslated regions, was markedly reduced by ectopic miR-1. Up-regulation of several miR-1 targets including FoxP1, MET, and HDAC4 in primary human HCCs and down-regulation of their expression in 5-AzaC–treated HCC cells suggest their role in hepatocarcinogenesis. The inhibition of cell cycle progression and induction of apoptosis after re-expression of miR-1 are some of the mechanisms by which DNA hypomethylating agents suppress hepatocarcinoma cell growth. [Cancer Res 2008;68(13):5049–58]&lt;/p&gt;&lt;/div&gt;
Local Enhancement of Dopant Diffusion from Polycrystalline Silicon Passivating Contacts (2022)

Passivating contacts consisting of heavily doped polycrystalline silicon (poly-Si) and ultrathin interfacial silicon oxide (SiO<sub><i>x</i></sub>) films enable the fabrication of high-efficiency Si solar cells. The electrical properties and working mechanism of such poly-Si passivating contacts depend on the distribution of dopants at their interface with the underlying Si substrate of solar cells. Therefore, this distribution, particularly in the vicinity of pinholes in the SiO<sub><i>x</i></sub> film, is investigated in this work. Technology computer-aided design (TCAD) simulations were performed to study the diffusion of dopants, both phosphorus (P) and boron (B), from the poly-Si film into the Si substrate during the annealing process typically applied to poly-Si passivating contacts. The simulated 2D doping profiles indicate enhanced diffusion under pinholes, yielding deeper semicircular regions of increased doping compared to regions far removed from the pinholes. Such regions with locally enhanced doping were also experimentally demonstrated using high-resolution (5-10 nm/pixel) scanning spreading resistance microscopy (SSRM) for the first time. The SSRM measurements were performed on a variety of poly-Si passivating contacts, fabricated using different approaches by multiple research institutes, and the regions of doping enhancement were detected on samples where the presence of pinholes had been reported in the related literature. These findings can contribute to a better understanding, more accurate modeling, and optimization of poly-Si passivating contacts, which are increasingly being introduced in the mass production of Si solar cells.
Unlearning tinnitus-related cerebral synchrony with acoustic coordinated reset stimulation: theoretical concept and modelling (2012)

Tinnitus is a deafferentation-induced phantom phenomenon characterized by abnormal cerebral synchrony and connectivity. Computationally, we show that desynchronizing acoustic coordinated reset (CR) stimulation can effectively counteract both up-regulated synchrony and connectivity. CR stimulation has initially been developed for the application to electrical deep brain stimulation. We here adapt this approach to non-invasive, acoustic CR stimulation. For this, we use the tonotopic organization of the central auditory system and replace electrical stimulation bursts applied to different brain sites by acoustically delivered tones of different pitch. Based on our simulations, we propose non-invasive acoustic CR stimulation as a possible novel therapy for tinnitus.
Natural Frequencies of Centrifugal Compressor Impellers for High Density Gas Applications (2008)

Characteristics of natural frequencies of an impeller and an equivalent disc were investigated in high-density gas to develop a method for predicting natural frequencies of centrifugal compressor impellers for high-density gas applications. The equivalent disc had outer and inner diameters equal to those of the impeller. We expected that natural frequencies would decrease with increasing the gas density because of the added-mass effect. However, we found experimentally that some natural frequencies of the impeller and the disc in high-density gas decreased but others increased. Moreover, we observed, under high-density condition, some resonance frequencies that we did not observe under low-density condition. These experimental results cannot be explained by only the added-mass effect. For simplicity, we focused on the disc to understand the mechanism of the behavior of natural frequencies. We developed a theoretical analysis of fluid-structure interaction considering not only the mass but also stiffness of gas. The analysis gave a qualitative explanation of the experimental results. In addition, we carried out a fluid-structure interaction analysis using the finite element method. The behavior of natural frequencies of the disc in high-density gas was predicted with errors less than 6%.
Towards Deterministic Reconfigurable Networks (2024)

Compared with legacy networks, programmable networks are highly flexible and need to be reconfigured dynamically. In this early work paper, we study the fast and consistent network update which is the key enabler to realize deterministic reconfigurable networks. The reconfiguration speed is one side of the coin. The ongoing best-effort traffic cannot be interrupted during the network reconfiguration as well. In terms of reconfiguration speed, we implement and compare our method with the state-of-the-art decentralized and centralized update methods.
Ultra-low-loss photonic circuits with integrated quantum dot single-photon sources (2021)

We demonstrate hybrid quantum photonic circuits comprising Si3N4 waveguides featuring losses in the dB/m range, with directly integrated quantum dot based single-photon sources.
How are the regulators regulated? The search for mechanisms that impose specificity on induction of cell death and NF-kappaB activation by members of the TNF/NGF receptor family. (2002)

Signals emanating from receptors of the tumor necrosis factor/nerve growth factor (TNF/NGF) family control practically all aspects of immune defense and, as such, constitute potential targets for therapeutic intervention through rational drug design. Indeed, arrest of these signals by blocking ligand-receptor interactions enables effective suppression of a variety of activities that are implicated in various pathologies, such as T and B lymphocyte activation and growth, inflammation, fibroblast proliferation, and cell death. To be therapeutically useful, however, inhibition of signaling should be restricted by determinants of specificity, at least to the same degree observed when blocking activation of individual receptors. In spite of their broad range of functions, receptors of the TNF/NGF family are known to activate just a few signaling pathways. Of these, the most extensively studied are the activation of the caspase protease cascade, which leads to cell death, and the activation of NF-kappaB (nuclear factor-kappaB) transcription factors through protein phosphorylation cascades. Until recently, most studies of the two pathways have solely focused on the core signaling complexes that are shared by the different receptors: death-inducing complexes containing the cysteine proteases caspase-8 and caspase-10, bound to the adapter protein MORT1/FADD (mediator of receptor-induced toxicity/Fas-associated DD protein), and the NF-kappaB-activating complex, composed of the protein kinases IKK1 (IkappaB kinase 1) and IKK2 (IkappaB kinase 2) and the regulatory subunit NEMO (NF-kappaB essential modulator; the 'IKK signalosome'). Knowledge has begun to emerge of additional molecules and mechanisms that affect these basic signaling complexes and impose specificity on their function.
Electroplating lithium transition metal oxides (2017)

Materials synthesis often provides opportunities for innovation. We demonstrate a general low-temperature (260°C) molten salt electrodeposition approach to directly electroplate the important lithium-ion (Li-ion) battery cathode materials LiCoO<sub>2</sub>, LiMn<sub>2</sub>O<sub>4</sub>, and Al-doped LiCoO<sub>2</sub>. The crystallinities and electrochemical capacities of the electroplated oxides are comparable to those of the powders synthesized at much higher temperatures (700° to 1000°C). This new growth method significantly broadens the scope of battery form factors and functionalities, enabling a variety of highly desirable battery properties, including high energy, high power, and unprecedented electrode flexibility.
Applications of Fourier transform Raman spectroscopy to studies of thin polymer films (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTApplications of Fourier transform Raman spectroscopy to studies of thin polymer filmsC. G. Zimba, S. Turrell, J. D. Swalen, V. M. Hallmark, and J. F. RaboltCite this: J. Phys. Chem. 1990, 94, 2, 939–943Publication Date (Print):January 1, 1990Publication History Published online1 May 2002Published inissue 1 January 1990https://pubs.acs.org/doi/10.1021/j100365a080https://doi.org/10.1021/j100365a080research-articleACS PublicationsRequest reuse permissionsArticle Views189Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Solid-State Polymerization of Polycarbonates Using Supercritical CO2 (1999)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTADDITION / CORRECTIONThis article has been corrected. View the notice.Solid-State Polymerization of Polycarbonates Using Supercritical CO2Stephen M. Gross, Devin Flowers, George Roberts, Douglas J. Kiserow, and Joseph M. DeSimoneView Author Information Venable and Kenan Laboratories, CB# 3290, Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, Department of Chemical Engineering, North Carolina State University, Raleigh, North Carolina 27695-7905, Chemical Sciences Division, Army Research Office, PO Box 12211, Research Triangle Park, North Carolina 27709-2211 Cite this: Macromolecules 1999, 32, 9, 3167–3169Publication Date (Web):March 11, 1999Publication History Received2 September 1998Revised8 February 1999Published online11 March 1999Published inissue 1 May 1999https://pubs.acs.org/doi/10.1021/ma981395yhttps://doi.org/10.1021/ma981395yrapid-communicationACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views474Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Crystallinity,Inorganic carbon compounds,Polymerization,Polymers,Thermoresponsive polymers Get e-Alerts
The adult Göttingen minipig as a model for chronic heart failure after myocardial infarction: focus on cardiovascular imaging and regenerative therapies. (2008)

Porcine models have become increasingly popular in cardiovascular research. The standard farm pig rapidly increases in body weight and size, potentially confounding serial measurements of cardiac function and morphology. We developed an adult porcine model that does not show physiologic increases in heart mass during the study period and is suitable for long-term study. We compared adult minipigs with the commonly used adolescent Yorkshire swine. Myocardial infarction was induced in adult Göttingen minipigs and adolescent Yorkshire swine by occlusion of the left anterior descending coronary artery followed by reperfusion. At 8 wk after infarction, the left ventricular ejection fraction was 34.1 +/- 2.3% in minipigs and 30.7 +/- 2.0% in Yorkshire swine. The left ventricular end-diastolic mass in Yorkshire pigs assessed by magnetic resonance imaging increased 17 +/- 5 g, from 42.6 +/- 4.3 g at week 1 after infarction to 52.8 +/- 6.6 g at week 8, whereas it remained unchanged in minipigs. Cardiac anatomy and physiology in adult minipigs were evaluated invasively by angiography and noninvasively by Multidetector Computed Tomography and by Magnetic Resonance Imaging at 1.5 T and 3 T prior to myocardial infarction and during folow-up. This porcine heart failure model is reproducible, mimics the pathophysiology in patients who have experienced myocardial infarction, and is suitable for imaging studies. New heart failure therapies and devices can be tested preclinically in this adult animal model of chronic heart failure.