gebhart/patrepeval huggingface dataset:
Depressive symptoms, frailty, and adverse outcomes among kidney transplant recipients (2018)

Depressive symptoms and frailty are each independently associated with morbidity and mortality in kidney transplant (KT) recipients. We hypothesized that having both depressive symptoms and frailty would be synergistic and worse than the independent effect of each. In a multicenter cohort study of 773 KT recipients, we measured the Fried frailty phenotype and the modified 18-question Center for Epidemiologic Studies-Depression Scale (CES-D). Using adjusted Poisson regression and survival analysis, we tested whether depressive symptoms (CES-D score > 14) and frailty were associated with KT length of stay (LOS), death-censored graft failure (DCGF), and mortality. At KT admission, 10.0% of patients exhibited depressive symptoms, 16.3% were frail, and 3.6% had both. Recipients with depressive symptoms were more likely to be frail (aOR = 3.97, 95% CI: 2.28-6.91, P < 0.001). Recipients with both depressive symptoms and frailty had a 1.88 times (95% CI: 1.70-2.08, P < 0.001) longer LOS, 6.20-fold (95% CI:1.67-22.95, P < 0.01) increased risk of DCGF, and 2.62-fold (95% CI:1.03-6.70, P = 0.04) increased risk of mortality, compared to those who were nonfrail and without depressive symptoms. There was only evidence of synergistic effect of frailty and depressive symptoms on length of stay (P for interaction < 0.001). Interventions aimed at reducing pre-KT depressive symptoms and frailty should be explored for their impact on post-KT outcomes.
Combined Three-Dimensional Magnetic Resonance Guided Optical Spectroscopy for Functional and Molecular Imaging of Human Breast Cancer (2011)

Dynamic contrast enhanced magnetic resonance is used to image high-risk patients for breast cancer because of its higher sensitivity to tumors than mammography. We focus on Near Infrared Spectroscopy (NIRS) imaging and Fluorescence Molecular Tomography (FMT), emerging imaging techniques that non-invasively quantify optical properties of total hemoglobin, oxygen saturation, water content, scattering, lipid concentration and endogenous Protoporphyrin IX (PpIX) emission. We present methods on combining the synergistic attributes of DCE-MR, NIRS, and FMT for in-vivo imaging of breast cancer in three dimensions using a custom optical MR breast coil and diffusion based light modeling software, NIRFAST. We present example results from a breast cancer patient. Preliminary results show elevated hemoglobin values and water fraction. Fluorescence values in the tumor region, however, were not always elevated above the surrounding tissue as we had expected. The additional information gained from NIRS and FMT may improve the ability to distinguish between malignant and benign lesions during MR imaging. These dual modality instruments will provide complex anatomical and molecular prognostic information, and may decrease the number of biopsies, thereby improving patient care.
260 MHz, MW-level thin-disk oscillator (2015)

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Esthetic Dentistry and Ceramic Restorations (1998)

Restorative dentistry is based on four basic principles: biocompatibility of materials, reduced tissue damage, longevity of restorations and esthetic considerations. The steady advance in the development of materials, coupled with improved understanding of ceramic bonding, reinforcement and light transmission, has given further emphasis to the esthetic aspects of restoration. This extensively illustrated text, prepared by a team with international experience, discusses these basic principles and presents a detailed clinical guide, for both the practitioner and the technician, to the esthetic techniques required for improving, restoring or rebuilding single teeth with various ceramic systems.
Ribonucleotide Reductase Immunoreactivity in Adenocarcinoma Cells and Malignant or Reactive Mesothelial Cells in Serous Effusions (2003)

RNR-R2 immunostaining can be useful as an adjunct for differentiating AC or MM from RM in serous effusions.
Lactate transporters and vascular factors in HPV-induced squamous cell carcinoma of the uterine cervix (2014)

The results herein presented point at MCT4 as a promising therapeutic target in squamous cells carcinoma of the uterine cervix. Importantly, we show a possible association between lactate transport and angiogenesis, which should be further explored.
Ultrahigh resolution OCT using continuum generation in an air-silica microstructure optical fiber (2001)

We demonstrate ultrahigh resolution optical coherence tomography using the continuum generation in an air-silica microstructure fiber. A broadband OCT system was developed, supporting a bandwidth of 370 nm at 1.3 μm center wavelength. We achieved longitudinal resolutions of 2.5 pm in air, or ~2 μm in tissue. This is to our knowledge the highest longitudinal OCT resolution demonstrated at this wavelength range and the first application of this new light source for OCT. We will also describe the application of this technique for imaging biological tissue in vivo.
Tunable plasmonic crystal (2023)

A tunable plasmonic crystal comprises several periods in a two-dimensional electron or hole gas plasmonic medium that is both extremely subwavelength (.about..lamda./100) and tunable through the application of voltages to metal electrodes. Tuning of the plasmonic crystal band edges can be realized in materials such as semiconductors and graphene to actively control the plasmonic crystal dispersion in the terahertz and infrared spectral regions. The tunable plasmonic crystal provides a useful degree of freedom for applications in slow light devices, voltage-tunable waveguides, filters, ultra-sensitive direct and heterodyne THz detectors, and THz oscillators.
Sputtered W-Ti Film for X-Ray Mask Absorber (1992)

Properties of DC-sputtered W-Ti absorber films such as internal stress, density and microstructure were systematically investigated for X-ray mask application. Smooth, stress-free amorphous W-Ti films with a comparatively high density of 16.5-17.0 g/cm 3 were obtained by optimizing several conditions: gas pressure, N 2 content in the working gas, DC power density and annealing temperature. The reproducibility of the film stress was about ±5×10 7 Pa. Reproducibility was found to be mainly determined by the degree to which the sputtering tool used could be controlled. Furthermore, it was confirmed that the optimized absorber films offered good stability under stress within 1×10 7 Pa when stored in an air atmosphere for more than 250 days.
Analysis of PD control of mechanical systems with dynamic backlash (2021)

This paper paper is devoted to the analysis and control of a simple rigid body mechanical system with dynamic backlash. Contrary to most of the existing work in control literature we explicitly treat all the dynamic and non-linear characteristics of this system. We show that appropriate gains in a PD control scheme can be selected such that the closed-loop system is locally stable around a desired symmetric periodic orbit. Two cases are analyzed: the colocated and the non-colocated controllers. It is shown that both schemes are quite similar, although the non-colocated case yields, as expected, smaller existence and stability regions. This work finds potential application in several areas including the control of kinematic chains with joint clearance and vibro-impact systems.
Vaccine against Helicobacter pylori infection (2002)

Sažetak: Peroralna imunizacija ureazom Helicobacter pylori uzrokuje u miseva pojavu žastitne imunosti od infekcije sojem Helicobacter felis. Otkrivanjem prvog zastitnog antigena (ureaza) slijedila su otkrica i evaluacije drugih mogucih zastitnih antigena, kao npr. proteina toplinskog soka (HspA) i citotoksicnog VacA antigena. Konacni odabir pripravaka antigena u vakcini ovisi o konzervaciji antigena među sojevima Helicobacter pylori, njihovoj virulenciji i ocuvanju imunogenih svojstava ako se koriste rekombinantni proteini. Nadalje, terapijska imunizacija pokazala se također ucinkovita u eradikaciji Helicobacter u kronicno inficiranih pokusnih životinja. Takvi poticajni rezultati daju naslutiti mogucnost koristenja postupka imunizacije u lijecenju infekcija Helicobacter pylori u ljudi. Ovim clankom prikazani su rezultati dosadasnjih istraživanja te smjernice za istraživanja Helicobacter vakcina u buducnosti. Abstract: Oral immunization with the urease of Helicobacter pylori was shown to induce protection against Helicobacter felis in mice. The first identification of a protective antigen (urease) was followed by the identification of other protective antigens, such as the heat-shock protein (HspA) and the vacuolating cytotoxin VacA. The final selection of the antigens to be used in a vaccine depends on the conservation of these antigens among Helicobacter pylori strains, their role as virulence factors and conservation of their immunogenic properties when expressed as recombinant proteins. Furthermore, therapeutic immunizations were also effective in eradication Helicobacter from chronically infected animals. These encouraging results imply that immunization may also be useful in the therapy of Helicobacter pylori infections in humans. In this review, preliminary data and directions for future research on Helicobacter vaccines are described.
Reprogramming protein kinase substrate specificity through synthetic mutations (2016)

Protein kinase specificity is largely imparted through substrate binding pocket motifs. Missense mutations in these regions are frequently associated with human disease, and in some cases can alter substrate specificity. However, current efforts at decoding the influence of mutations on substrate specificity have been focused on disease-associated mutations. Here, we adapted the Proteomic Peptide Library (ProPeL) approach for determining kinase specificity to the task of exploring structure-function relationships in kinase specificity by interrogating the effects of synthetic mutation. We established a specificity model for the wild-type DYRK1A kinase with unprecedented resolution. Using existing crystallographic and sequence homology data, we rationally designed mutations that precisely reprogrammed the DYRK1A kinase at the P+1 position to mimic the substrate preferences of a related kinase, CK II. This study illustrates a new synthetic biological approach to reprogram kinase specificity by design, and a powerful new paradigm to investigate structure-function relationships underpinning kinase substrate specificity.
In-memory adder functionality in 1S1R arrays (2015)

Memristive devices enable non-volatile data storage and in-memory computing capabilities. By using stateful logic approaches, hybrid CMOS nano-crossbar arrays offer additional functionalities such as arithmetic operations. To enable storage and computing on large-scale arrays, parasitic current paths within the array must be avoided. Therefore, for example, a complementary resistive switch (1CRS) or a bipolar rectifying element (‘selector’) in series to a resistive switching device (1S1R) is required at each cross-point junction to suppress low-ohmic sneak paths. In this work 1S1R arrays are considered. First, the in-memory adder concept, initially developed for CRS arrays, is adjusted for a 1S1R array. After that an optimized design is presented and verified by means of memristive simulations. Third, the energy consumption of both concepts is evaluated as a function of array size, and the delay of memristive adder designs are compared quantitatively.
Surface Expression of Notch1 on Thymocytes: Correlation with the Double-Negative to Double-Positive Transition (2003)

Notch1 plays a critical role in regulating T lineage commitment during the differentiation of lymphoid precursors. The physiological relevance of Notch1 signaling during subsequent stages of T cell differentiation has been more controversial. This is due in part to conflicting data from studies examining the overexpression or targeted deletion of Notch1 and to difficulties in distinguishing between the activities of multiple Notch family members and their ligands, which are expressed in the thymus. We employed a polyclonal antiserum against the extracellular domain of Notch1 to study surface expression during thymopoiesis. We found high levels of Notch1 on the cell surface only on double negative (DN) stage 2 through the immature single-positive stage of thymocyte development, before the double-positive (DP) stage. The Notch signaling pathway, as read out by Deltex1 expression levels, is highly active in DN thymocytes. When an active Notch1 transgene, Notch1IC, is exogenously introduced into thymocytes of recombinase-activating gene 2-deficient mice, it promotes proliferation and development to the DP stage following anti-CD3 treatment without apparently affecting the intensity of pre-TCR signaling. In addition, a stromal cell line expressing the Notch ligand, Delta-like-1, promotes the in vitro expansion of wild-type DN3 thymocytes in vitro. Consistent with other recent reports, these data suggest a role for Notch1 during the DN to DP stage of thymocyte maturation and suggest a cellular mechanism by which Notch1IC oncogenes could contribute to thymoma development and maintenance.
Chameleonic Dye Adapts to Various Environments Shining on Macrocycles or Peptide and Polysaccharide Aggregates (2017)

This work describes latent fluorescence particles (LFPs) based on a new environmentally sensitive carbazole compound aggregated in water and their use as sensors for probing various cavitands and the different stages of aggregating systems. Cyclodextrins (CDs), cucurbit[n]urils (CB[n], n = 6, 7, 8), and a resorcinarene capsule were used to study the dynamic nature of the LFPs. The fluorescence was dramatically enhanced by a proposed disaggregation-induced emission enhancement (DIEE) mechanism with specific features for CB[n]. Then, the aggregated states of the dipeptides Leu-Leu, Phe-Phe, and Fmoc-Leu-Leu (vesicles, crystals, fibers) were studied by fluorescence spectroscopy and confocal fluorescence microscopy thanks to the adaptive and emissive behavior of the LFPs, allowing us to study an interesting polymorphism phenomenon. The LFPs have then been used in the sensing of the aggregation of the polysaccharide alginate, for which distinct fluorescence turn-on is detected upon stepwise biopolymer assembly, and for amylose detection. The carbazole particles not only adapt to various environments but also display multicolor fluorescent signals. They can be used for the fast probing of the aggregation propensity of newly prepared molecules or biologically relevant compounds or to accelerate the discovery of new macrocycles or of self-assembling peptides in water.
Isotope Effect on Physical Properties of BEDT-TTF Based Organic Superconductors (1992)

Abstract The isotope shifts of the superconducting transition temperature for K-(BEDT-TTF)2Cu[N(CN)2]Br were evaluated from the resistivity and dc magnetization measurements. The deuteration of the terminal ethylene groups of the donor molecule lowered Tc by 0.4 to 0.5K, whereas the 13C substitution on the same fragments gave no isotope shifts within the experimental accuracy.
Structural and band alignment properties of Al2O3 on epitaxial Ge grown on (100), (110), and (111)A GaAs substrates by molecular beam epitaxy (2013)

Structural and band alignment properties of atomic layer Al2O3 oxide film deposited on crystallographically oriented epitaxial Ge grown in-situ on (100), (110), and (111)A GaAs substrates using two separate molecular beam epitaxy chambers were investigated using cross-sectional transmission microscopy (TEM) and x-ray photoelectron spectroscopy (XPS). High-resolution triple axis x-ray measurement demonstrated pseudomorphic and high-quality Ge epitaxial layer on crystallographically oriented GaAs substrates. The cross-sectional TEM exhibited a sharp interface between the Ge epilayer and each orientation of the GaAs substrate as well as the Al2O3 film and the Ge epilayer. The extracted valence band offset, ΔEv, values of Al2O3 relative to (100), (110), and (111) Ge orientations using XPS measurement were 3.17 eV, 3.34 eV, and 3.10 eV, respectively. Using XPS data, variations in ΔEv related to the crystallographic orientation were ΔEV(110)Ge&amp;gt;ΔEV(100)Ge≥ΔEV(111)Ge and the conduction band offset, ΔEc, related to the crystallographic orientation was ΔEc(111)Ge&amp;gt;ΔEc(110)Ge&amp;gt;ΔEc(100)Ge using the measured ΔEv, bandgap of Al2O3 in each orientation, and well-known Ge bandgap of 0.67 eV. These band offset parameters are important for future application of Ge-based p- and n-channel metal-oxide field-effect transistor design.
Radio-Frequency Sustainment of Laser Initiated, High-Pressure Air Constituent Plasmas* (2003)

In this paper we investigate the feasibility of creating a high‐density ∼ 1012−1014 cm−3, large volume seed plasma in air constituents by laser (300 mJ, 20(±2) ns) preionization of an organic gas seeded in high‐pressure gas mixtures and then sustained by efficient absorption of rf power (1–25 kW pulsed) through inductive coupling of the wave fields. A multi‐turn helical antenna is used to couple radio‐frequency power through a capacitive matching network. A 105 GHz interferometer is employed to obtain the plasma density in the presence of high collisionality utilizing phase shift and amplitude attenuation data. TMAE Plasma decay mechanisms with and without the background gas are examined.
Frequency representation in auditory cortex of the common marmoset (Callithrix jacchus jacchus) (1986)

The location and characteristics of the primary auditory cortex of the common marmoset, Callithrix jacchus jacchus, were determined in five anesthetized male adult animals by mapping the responses of cortical units and unit clusters to pure tone stimuli presented to the contralateral ear. The primary auditory cortex lies largely ventral to the lateral sulcus, the only major fissure on the lateral cortex of this smooth-brained primate, but in some animals it may extend significantly down the ventral bank of this sulcus. Responses are distributed such that low best frequencies are found rostroventrally whereas high best frequencies occur caudally. The disposition of frequency-band contours is fan-shaped, with contours separating low-frequency octaves nearly parallel to the lateral sulcus and high-frequency (greater than 8 kHz) contours perpendicular to that sulcus. Best frequencies range from 0.6 to 30 kHz across the primary field, but there is a disproportionate representation of the three octaves between 2 and 16 kHz. The most sensitive thresholds (as low as -2 dB SPL) are found between 7 and 9 kHz. The primary auditory cortex is similar in cytoarchitecture to that reported for the cat, showing a blurring of lamination in the middle layers (II-IV) and a preponderance of small cells in these merged layers, giving a highly granular appearance. The accessibility of the cochlear representation on the gyral surface makes the marmoset an attractive animal for studies of primate auditory cortex.
Wound bed preparation and a brief history of TIME (2004)

Management of chronic wounds has progressed from merely assessing the status of a wound to understanding the underlying molecular and cellular abnormalities that prevent the wound from healing. The concept of wound bed preparation has simultaneously evolved to provide a systematic approach to removing these barriers to natural healing and enhancing the effects of advanced therapies. This brief review of wound bed preparation traces the development of these concepts and explains how to apply systematic wound management using the TIME acronym - tissue (non viable or deficient), infection/inflammation, moisture (imbalance) and edge (non advancing or undermined).
Six‐Month Ischemic Mice Show Sensorimotor and Cognitive Deficits Associated with Brain Atrophy and Axonal Disorganization (2013)

tMCAo in mice induces sensorimotor and cognitive impairments detectable at least up to 6 months postinjury, associated with brain atrophy, and axonal and myelin damage of the external capsule. These behavioral tests and anatomical investigations may represent important tools in translational studies in cerebral ischemia.
Interleukin-13 inhibits interleukin-2-induced proliferation and protects chronic lymphocytic leukemia B cells from in vitro apoptosis (1996)

Human interleukin-13 (IL-13) acts at different stages of the normal B-cell maturation pathway with a spectrum of biologic activities overlapping those of IL-4. B chronic lymphocytic leukemia (B-CLL) is characterized by the accumulation of slow-dividing and long-lived monoclonal B cells, arrested at the intermediate stage of their differentiation. In vitro, B-CLL cells exhibit a spontaneous apoptosis regulated by different cytokines. In this report, we show that IL-13 (10 to 200 ng/mL) acts directly on monoclonal B-CLL cells from 12 patients. (1) IL-13 enhances CD23 expression and induces soluble CD23 secretion by B-CLL cells but does not exhibit a growth factor activity. (2) IL-13 inhibits IL-2 responsiveness of B-CLL cells, activated either with IL-2 alone or through crosslinking of lgs or ligation of CD40 antigen. (3) IL-13 protects B-CLL cells from in vitro spontaneous apoptosis. The effects of IL-13 on neoplasic B cells were slightly less than those of IL-4 and occurred independently of the presence of IL-4. The present observations show that IL-13 may exhibit a negative regulatory effect on neoplasic B cells in contrast with that observed in normal B cells, and suggest that IL-13 could be an important factor in the pathogenesis of CLL by preventing the death of monoclonal B cells. Moreover, B-CLL may be an interesting model to study the regulation of the expression of IL-13 receptor and/or signal transduction pathways.
Performance evaluation of an integrated photonic convolutional neural network based on delay buffering and wavelength division multiplexing (2019)

Photonic technologies have shown a promising way to build high-speed and high-energy-efficiency neural network accelerators. In previously presented photonic neural networks, architectures are mainly designed for fully-connected layers. When convolutional layers are executed in such neural networks, the large-scale electrooptic modulation array heavily increases the energy dissipation on chip. To increase the energy efficiency, here we show an integrated photonic architecture specifically for convolutional layer calculations. Optical delay lines replace electronics to execute data manipulations on optical chip, reducing the scale of electro-optic modulation array. Consequently, the energy dissipation of these parts is mitigated. Powered by wavelength division multiplexing, the footprint of delay lines is significantly reduced compared with previous art, thus being practical to fabricate. We evaluate the potential performance of the proposed architecture with respect to component flaws in practical fabrications. According to the results, with well-controlled system insertion loss, energy efficiency of the proposed architecture would surpass previously presented works and the state-of-art electronic processors. We anticipate the proposed architecture is beneficial for future fast and energy-efficient convolutional neural network accelerators.