gebhart/patrepeval huggingface dataset:
Novel TWT interaction circuits for high frequency applications (2004)

Summary form only given. The initial focus of this program is on the development of Ka-band TWTs producing 10 W of RF power. These devices would potentially be used as RF sources for phased array antennas. This requires innovative TWT designs, which result in improved repeatability, increased yield and reliability, and reduced cost over existing Ka-band devices. To do this, the batch nature of micro-electro-mechanical systems (MEMS) fabrication techniques is ideal. However, many TWT interaction circuits, such as the conventional helix, are not compatible with MEMS techniques. Thus, Calabazas Creek Research, Inc. (CCR) has computationally investigated several innovative TWT interaction circuits based on MEMS fabrication. These include the square helix, planar helix and modified folded waveguide circuits.
Retroviruses for Cancer Therapy (2014)

Retroviruses are enveloped RNA viruses that can efficiently integrate a DNA copy of their genomes into the host cell DNA. Retroviral vectors have proved to be invaluable both as research tools and as effective gene-delivery systems. Retrovirus-based RNA interference (RNAi) vectors take advantage of the characteristics of retroviral vectors to permanently introduce RNAi triggers [short hairpin RNA (shRNA) or small interfering RNA (siRNA)] into target cells, resulting in specific and persistent suppression of the targeted gene. Intensive efforts have been made to develop and optimize retroviral vectors to improve their biosafety profile and efficiency, thereby allowing their wider use in translational studies and clinical trials. Lentiviruses, a subcategory of the retrovirus family, have additional advantages: they are able to transduce nondividing cells, have larger packaging capacity for the transgene, and tend to integrate within active genes rather than near transcriptional start sites or proto-oncogenes. These traits make them the most preferred gene-transfer system for both local applications and ex vivo gene therapy. In this chapter we introduce the principles of, and advances in, retroviral vector technology. We discuss with particular interest the basics and design features of gammaretroviral, alpharetroviral, foamyviral, and lentiviral vectors and focus on the development of gene or RNAi-based therapies mediated by these vectors for cancer, monogenic diseases, and HIV/AIDS.
Supplementary Figure 1 from Adoptive Transfer of MART-1 T-Cell Receptor Transgenic Lymphocytes and Dendritic Cell Vaccination in Patients with Metastatic Melanoma (2023)

&lt;p&gt;PDF file - 82KB, TCR transgenic cell therapy manufacture protocol modifications.&lt;/p&gt;
8.1 Improved power-side-channel-attack resistance of an AES-128 core via a security-aware integrated buck voltage regulator (2017)

Power side-channel attacks (PSCA), e.g. Differential Power Analysis (DPA) and Correlation Power Analysis (CPA), are major threats to the security of crypto engines in SoC platforms. Circuit-level SCA countermeasures to achieve data-independent supply current patterns via implementation of crypto engines using non-conventional logic (complemented or charge recovery) and local switched-capacitor-based supply current equalization have been demonstrated. The feasibility of using bandwidth-limited integrated low dropout regulators, multi-phase switched-capacitor VRs with phase-randomization and integrated inductive voltage regulators (IVR) to enhance PSCA resistance have been explored before via simulation studies. In this paper, we demonstrate improved PSCA resistance offered by an on-die all-digital high-frequency IVR in 130nm CMOS for a standard (unprotected) 128b Advanced Encryption Standard (AES) core designed in static CMOS logic. The IVR features a configurable digital proportional-integral-derivative (PID) controller, a digital discontinuous conduction mode (DCM) controller, and a loop randomization (LR) block, all of which are utilized to enhance PSCA resistance with minimal power/performance/area overheads, while maintaining adequate local voltage regulation and transient performance.
Determination of wurtzite GaN lattice polarity based on surface reconstruction (1998)

We identify two categories of reconstructions occurring on wurtzite GaN surfaces, the first associated with the N face, (0001̄), and the second associated with the Ga face, (0001). Not only do these two categories of reconstructions have completely different symmetries, but they also have different temperature dependence. It is thus demonstrated that surface reconstructions can be used to identify lattice polarity. Confirmation of the polarity assignment is provided by polarity-selective wet chemical etching of these surfaces.
Ultrafast and High-Contrast Electrochromism on Bendable Transparent Carbon Nanotube Electrodes (2010)

Poly(3,4-ethylenedioxythiophene) and tungsten oxide films with enhanced electrochromism were prepared by templated electrodeposition on flexible transparent carbon nanotube electrodes. The nanostructured porous architectures obtained by coating the nanotube templates exhibited high contrast with faster switching response, higher coloration efficiencies, and better long-term redox switching stability and resistance to flexure than their homologues on ITO-coated plastic electrodes.
Rapid onset of effect of sodium alginate on gastro-oesophageal reflux compared with ranitidine and omeprazole, and relationship between symptoms and reflux episodes (2006)

The objective of the open, randomised, four-period crossover study was to compare the time of onset of effect of sodium alginate (SA), omeprazole, ranitidine and control, based on oesophageal and intragastric pH and to determine any correlation between reflux symptoms and episodes in volunteers suffering from occasional gastro-oesophageal reflux. SA showed extensive prevention of acid exposure in the oesophagus compared with other treatments during the first hour. Overall, SA was more effective than control or omeprazole and comparable with ranitidine. There was little evidence of association between 'oesophageal' symptoms and reflux episodes, but associations between 'gastric' symptoms and acidity in the oesophagus, fundus and corpus were apparent. For an immediate reduction in gastro-oesophageal reflux into the oesophagus and gastric acidity during the first hour, SA was significantly superior to control, ranitidine and omeprazole. Ranitidine showed a superior effect from 2 h, consistent with its pharmacological mode of action.
Self-Assembled Double Ladder Structure Formed Inside Carbon Nanotubes by Encapsulation of H8Si8O12 (2009)

Unique low-dimensional SiO(2)-based nanomaterials can be encapsulated and synthesized inside the nanometer-scale one-dimensional internal spaces of carbon nanotubes (CNTs). In this study, various single-walled CNTs (SWNTs) and double-walled CNTs (DWNTs) having different diameters are used as containers for cubic octameric H(8)Si(8)O(12) molecules. High-resolution transmission electron microscopy (HRTEM), Fourier transform infrared (FT-IR) spectroscopy, and Raman spectroscopy observations revealed that, depending on the diameter of the CNTs, two types of structures are formed inside the SWNTs and DWNTs: In the case of those CNTs having inner diameters ranging from 1.2 to 1.4 nm, a new ordered self-assembled structure composed of H(8)Si(4n)O(8n-4) molecules was formed through the transformation of H(8)Si(8)O(12); however, in the case of CNTs having inner diameters larger than 1.7 nm, a disordered structure was formed. This behavior may indicate that strong interactions occur between the CNTs and the encapsulated H(8)Si(4n)O(8n-4) molecules.
<title>Coherent optical processor for image-quality metric measurement</title> (1997)

Image quality metrics that can be obtained optically using coherent optical systems are discussed. Coherent optical processing to measure these image quality metrics includes several steps: (a) transformation ofthe image plane intensity distribution into a phase modulation ofthe coherent wave using a liquid crystal television; (b) diffraction of the phase modulated wave over a specified distance to enhance particular image spatial frequencies; (c) a secondary intensity-phase transformation; and (d) application of an image quality analyzer based on speckle field statistical properties. We present experimental results, along with corresponding numerical simulations, that demonstrate the effectiveness ofthese technique for adaptive correction of phase-distorted extended source images.
Stereoselective ketone reductions: reduction of 4-tert-butylcyclohexanone by alkylsilanes in the presence of rhodium(I) and ruthenium(II) catalysts (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereoselective ketone reductions: reduction of 4-tert-butylcyclohexanone by alkylsilanes in the presence of rhodium(I) and ruthenium(II) catalystsM. F. Semmelhack and Raj N. MisraCite this: J. Org. Chem. 1982, 47, 12, 2469–2471Publication Date (Print):June 1, 1982Publication History Published online1 May 2002Published inissue 1 June 1982https://pubs.acs.org/doi/10.1021/jo00133a045https://doi.org/10.1021/jo00133a045research-articleACS PublicationsRequest reuse permissionsArticle Views633Altmetric-Citations48LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
SiO2/InP interface formation: Thermodynamic considerations (1980)

Chemical vapor deposited SiO2 has previously been shown to form a useable insulator for InP MIS devices. In this paper possible reactions between Si, SiO, SiO2, O2, and InP and its oxides are investigated by calculation of the change in enthalpy of the reactions. The calculations indicate that no reaction is expected between SiO2 and InP or its oxides. However, both Si and SiO reduce the oxides of In and P. The reaction between InP and Si appears to be weak but possible. The various methods of depositing SiO2 are also examined in order to predict which of these methods is the least likely to cause reaction between the substrate and the depositing species.
Preparation and properties of CuCr2Se4 ferromagnetic spinel nanocrystals (2006)

Polycrystalline and nanocrystalline samples of the CuCr2Se4 ferromagnetic spinel are synthesized. The mean size of nanocrystals is 50 nm. The Curie temperature of spinel nanocrystals (465 K) is higher than that of spinel polycrystals (435 K). Laser irradiation at a wavelength of 1.5 μm (in an external magnetic field) increases the magnetization of the noncrystalline powder. Most likely, this can be explained by the change in the orientation of magnetic moments of single-domain nanoparticles. The observed effect reaches a maximum in magnetic fields with a strength lower than that of the saturation field.
Engine knock margin control using in-cylinder pressure data: Preliminary results (2017)

Knock is an undesired phenomenon occurring in spark ignited engines and is controlled acting on the spark timing. This paper presents a closed-loop architecture that makes possible to address the knock control problem with a standard model-based design approach. An engine knock margin estimate is feedback controlled through a PI regulator and its target value is computed starting from the desired knock probability. A black-box modelling approach is used to identify the dynamics between the spark timing and the knock margin and a traditional model-based controller synthesis is performed. Experimental results at the test bench show that, compared to a conventional strategy, the proposed approach allows for a better compromise between the controller speed and the variability of the spark timing. Moreover, another advantage w.r.t. the conventional strategies is that closed-loop performance prove to be constant for different reference probabilities, leading to a more regular engine behaviour.
Poster Abstract: EcoLoc: Encounter-Based Collaborative Indoor Localization (2017)

This work present a collaborative indoor localization system which provides a lightweight location estimation solution for resource constrained IoT devices. The proposed EcoLoc, an encounterbased collaborative indoor localization system, uses the chance of encounter to enable the sharing and composition of multiple trajectories which are generated by Pedestrian Dead Reckoning. A collaborative version of Conditional Random Field is developed to merge these trajectories and generate the most probable location while signicantly shortening the convergence distance compared to the state-of-the-art techniques as particle filter. EcoLoc runs in realtime and can be distributed to resource-limited devices as opposed to running on centralized servers. Using the tablet and WICED Sense IoT platform, the convergence distance can be shorten by up to 40% on Android tablet and up to 50% on the WICED-Sense.
Genetic Basis of Pancreas Cancer Development and Progression: Insights from Whole-Exome and Whole-Genome Sequencing (2012)

Pancreatic cancer is caused by inherited and acquired mutations in specific cancer-associated genes. The discovery of the most common genetic alterations in pancreatic cancer has provided insight into the fundamental pathways that drive the progression from a normal cell to noninvasive precursor lesions and finally to widely metastatic disease. In addition, recent genetic discoveries have created new opportunities to develop gene-based approaches for early detection, personalized treatment, and molecular classification of pancreatic neoplasms.
SYNTHESIS OF BIS-nAPHTHOPORPHYRINS (2012)

Ethanonaphthoporphyrins with a halogen atom at the ζ position were prepared by the [3+1] porphyrin synthesis of halogen-substituted ethanobenz[f]isoindole with a tripyrrane derivative.The halogeno porphyrins were converted to the corresponding ethynyl and pinacolatoboronyl compounds by Sonogashira and borylation reactions, respectively.Suzuki, Sonogashira, and Glaser coupling reactions of these ethanonaphthoporphyrins gave bis-porphyrins connected with no atom, acetylene, and butadiyne, respectively.Retro Diels-Alder reaction of these bis-porphyrins brought about the conversion of bicyclo[2.2.2]octadiene (BCOD) to benzene moieties to give bis-naphthoporphyrins, quantitatively.
Data-based feed-forward control in MIMO motion systems (2008)

For MIMO motion systems, a data-based feedforward control is derived and implemented on a wafer stage of a wafer scanner. On the basis of a quadratic objective function related to a performance-relevant time-frame of the servo error signals, the coefficients of a set of finite impulse response (FIR) filters are optimized using a Gauss-Newton method. Applied to the wafer stage both the optimization algorithm and the FIR filter structure provide the means to significantly improve upon scanning performance. This includes improved settling behavior, the reduced effect of cross talk by MIMO feedforward forces, and the generalizing properties of these forces at set-points other than for which is optimized.
Assessment of advanced windowing techniques for digital particle image velocimetry (DPIV) (2009)

The Fourier-based cross-correlation is the most common evaluation technique for DPIV estimation, due to its computational simplicity. However, because Fourier transforms are taken over discrete finite size regions, systematic errors are introduced due to the improper filtering of the input signals. This study explores the potential of advanced windowing techniques to attenuate these Fourier-based errors. The choice of window is shown to impact the spatial resolution, the measurement accuracy and the peak detection process. Error analysis using artificial image simulations is able to characterize a set of optimal windows onto a single performance characteristic. Using this analysis, a set of criteria is defined for an optimal windowing from which the analysis focused on the use of the 50% Gaussian window. The Gaussian window is further compared against standard evaluation techniques in both shear and vortex simulations, which indicate substantial performance benefits with this advanced technique. Further simulations reveal that background noise greatly amplifies the loss of correlation errors, which affect the peak detection process. However, these effects are easily overcome through the use of image preprocessing or the robust phase correlation. Images from the 2003 PIV challenge are used to validate the Gaussian window technique, which is able to remove nearly all of the erroneous vectors in comparison to standard windows.
Assembly of 20&#x03BC;m pitch Cu/Sn micro-bumps using high speed capillary self-alignment (2012)

We demonstrate high speed sub-micron assembly of 20μm pitch Cu/Sn micro-bumped dies. The positioning of the dies occurs through self-alignment in a liquid with capillary forces in a fraction of second. The surfaces of the dies are functionalized using Self Assembled Monolayer (SAM) to create sufficient wetting contrast as well as providing protection against oxidation during the assembly process.
A LTE/WLAN selection method based on a novel throughput estimation method (2017)

In this paper, we propose a novel radio access technology (RAT) selection method that can maximize total throughput by simultaneously selecting optimal RATs for a group of user equipments (UEs). To perform simultaneous selection, we also propose a novel throughput estimation method based on not wireless information collected from the existing network equipment but the accurate estimation of the amount of radio resources available for the UEs. Throughputs of all the UEs are estimated for all RAT selection patterns, by using the estimated available radio resources. The RAT selection method then selects a RAT selection pattern that gives the maximum total throughput. We conduct both simulations with a network simulator and field experiments with a commercially operating LTE network. The field experiments confirm that the proposed throughput estimation method can achieve an average estimation error of about 10%. The simulations confirm that the proposed method with a 10% throughput estimation error can achieve 96% throughput compared to that with perfect estimation. A conventional successive RAT selection method takes 1–10 minutes to achieve the same throughput as the proposed method, while the proposed simultaneous RAT selection method only takes about 1–10 seconds. Moreover, the conventional method achieves only 71% throughput of the proposed method with same processing time as the proposed method.
Framework of node architecture and traffic management algorithms for achieving QoS provisioning in integrated services networks (2000)

Recent market demand has put quality of service (QoS) support as the key feature in differentiating network products from various vendors. Advances in silicon technology has made it feasible to design per-flow based traffic management algorithms to control QoS with substantially improved performance over traditional class-based approach for the next generation switches and routers. This paper presents a node architecture with the aim of achieving QoS provisioning for the guaranteed service (GS), the controlled-load (CL), and the best-effort (BE) service offerings for the future integrated services networks. Under our node architecture, we propose several novel traffic management algorithms, which includes Adaptive Rate allocation for Controlled-load (ARC) flows, a hybrid model-based and measurement-based admission control algorithm for GS and CL flows, and a Quasi-Pushout Plus (or QPO+) packet discarding mechanism. Simulation results show that, once admitted into the network, our node architecture and traffic management algorithms are capable of providing hard performance guarantees to GS flows under all conditions, consistent (or soft) performance to CL flows under both light load and heavy load conditions, and minimal negative impact to conforming GS, CL and BE traffic should there be any non-conforming behavior from some CL flows. Furthermore, our node architecture and traffic management algorithms resolve some key problems associated with the traditional class-based approach.
Photonic-crystal waveguide biosensor (2007)

A photonic-crystal waveguide sensor is presented for biosensing. The sensor is applied for refractive index measurements and detection of protein-concentrations. Concentrations around 10 mug/ml (0.15muMolar) are measured with excellent signal to noise ratio, and a broad, dynamic refractive index sensing range extending from air to high viscous fluids is presented.
Theoretical Comparisons of Search Dynamics of Genetic Algorithms and Evolution Strategies (2005)

Genetic algorithms (GAs) and evolution strategies (ESs) are two widely used evolutionary algorithms. The main differences between GAs and ESs lie in their representations and variation operators, which result in very different search dynamics. In this paper, we compare the search dynamics of GAs and ESs theoretically using a theoretical framework for analyzing the search dynamics of evolution strategies proposed in this paper and a framework for genetic algorithms we suggested in (2005). Based on the theoretical analysis, interesting aspects of the search dynamics of GAs and ESs for single objective optimization are revealed. As an extension, preliminary results on the search dynamics of GAs for multi-objective optimization are also presented
Multiplexed RNAi therapy against brain tumor-initiating cells via lipopolymeric nanoparticle infusion delays glioblastoma progression (2017)

Brain tumor-initiating cells (BTICs) have been identified as key contributors to therapy resistance, recurrence, and progression of diffuse gliomas, particularly glioblastoma (GBM). BTICs are elusive therapeutic targets that reside across the blood-brain barrier, underscoring the urgent need to develop novel therapeutic strategies. Additionally, intratumoral heterogeneity and adaptations to therapeutic pressure by BTICs impede the discovery of effective anti-BTIC therapies and limit the efficacy of individual gene targeting. Recent discoveries in the genetic and epigenetic determinants of BTIC tumorigenesis offer novel opportunities for RNAi-mediated targeting of BTICs. Here we show that BTIC growth arrest in vitro and in vivo is accomplished via concurrent siRNA knockdown of four transcription factors (SOX2, OLIG2, SALL2, and POU3F2) that drive the proneural BTIC phenotype delivered by multiplexed siRNA encapsulation in the lipopolymeric nanoparticle 7C1. Importantly, we demonstrate that 7C1 nano-encapsulation of multiplexed RNAi is a viable BTIC-targeting strategy when delivered directly in vivo in an established mouse brain tumor. Therapeutic potential was most evident via a convection-enhanced delivery method, which shows significant extension of median survival in two patient-derived BTIC xenograft mouse models of GBM. Our study suggests that there is potential advantage in multiplexed targeting strategies for BTICs and establishes a flexible nonviral gene therapy platform with the capacity to channel multiplexed RNAi schemes to address the challenges posed by tumor heterogeneity.