gebhart/patrepeval huggingface dataset:
Half-Metallocene Titanium(IV) Phenyl Phenoxide for High Temperature Olefin Polymerization: Ortho-Substituent Effect at Ancillary o-Phenoxy Ligand for Enhanced Catalytic Performance (2009)

A series of mono- or dialkyl/phenyl o-substituted phenoxy ligands in half-metallocene titanium(IV) complexes was examined to determine the structure-catalytic activity relationship in high temperature olefin polymerization. Five different types of polymerization catalysts with different Cp/Cp* and mono- or disubstituted symmetric/asymmetric alkyl/phenyl phenoxide ancillary ligands were compared. This series was examined for ethylene homopolymerization after activation with Ph3CB(C6F5)4 and mMAO-7 at high temperatures (140 °C). Type 4 complexes of compounds 15−18 [33.0−39.0 kg/(mmol of Ti·h)] showed much higher catalytic activity than those found in types 1−3 and 5 [3.6−27.6 kg/(mmol of Ti·h)], and among the type 4 complexes, the Cp*/2-phenylphenoxy combination of compound 18 [39 kg/(mmol of Ti·h)] surpassed the Cp*/2-alkyl ligand systems of compounds 15−17 [33.0−36.0 kg/(mmol of Ti·h)]. The revolving nature of the phenoxy ligand around the Ti−O−C axis was identified by the NOSEY correlation peaks between the methyl protons of Cp* and protons of ancillary phenyl phenoxy ligand in compound 18. The conformational flexibility of the phenyl phenoxy ligand was further confirmed by a series of temperature-dependent ROSEY experiments based on the optimization of two conformational structures related by this rotation. Rotational barriers of 4.3 and 6.6 kcal/mol were estimated from theoretical DFT studies. DFT calculations of the transition states for ethylene insertion and termination were carried out for representative examples of types 4 (15, 16, 18), 3 (10, 12), and 1 (3) catalysts as well as the constrained geometry catalyst (CGC) as a reference. The preference for back-side insertion was a unique feature of the monosubstituted type 4 catalysts. The type 4 catalysts showed significant activities for ethylene/1-octene copolymerization affording high molecular weight poly(ethylene−co−1−octene)s (Mw = 107 000 −164 000) with unimodal molecular weight distributions (Mw/Mn = 2.08−4.15). The activity increased in the order of type 3 [90−132 kg/(mmol of Ti·h), in toluene, ethylene 30 atm, 1-octene 8 mL, 140 °C, 10 min.] < CGC (222) < type 4 (228−354). Among the type 4 series, compound 18 showed the best performance, reaching an activity of 354 kg/(mmol of Ti·h). The polymer density of 0.9148 g/mL for compound 18 was lower than that found in CGC (0.9154 g/mL), indicating higher 1-octene incorporation, which was further confirmed by an analysis of the 13C NMR spectra of the polymers (18, 2.73 mol % and CGC, 2.55 mol %).
Performance characteristics of a newly developed PET/CT scanner using NEMA standards in 2D and 3D modes. (2004)

The results show excellent system sensitivity with relatively uniform resolution throughout the FOV, making this scanner highly suitable for whole-body studies.
Light trapping in thin film solar cells using textured photonic crystal (2023)

A solar cell includes a photoactive region that receives light. A photonic crystal is coupled to the photoactive region, wherein the photonic crystal comprises a distributed Bragg reflector (DBR) for trapping the light.
Expression of hemagglutinin protein from the avian influenza virus H5N1 in a baculovirus/insect cell system significantly enhanced by suspension culture (2006)

Thus, the production of rHA1 using an insect suspension cell system provides a promising basis for economical production of a H5 antigen.
Método para la producción de óxido de propileno (2002)

Referencia OEPM: P9802135.-- Fecha de solicitud: 14/10/1998.-- Titular: Sumitono Chemical Company, Limited (Japón).
ChemInform Abstract: Ligand Assisted Nucleophilic Additions. Control of Site and Face Attack of Nucleophiles on 4‐Oxidoenones. (1988)

Abstract A properly positioned alkoxide‐metal complex, possessing a transferable ligand, can exert a high degree of regio‐ and stereocontrol on the delivery of that ligand to a second reactive site.
Design and Performance of Electrical Propulsion System of Extended Range Electric Vehicle (EREV) Chevrolet Volt (2014)

This paper presents the design and performance details of the Chevrolet Volt electric propulsion system. The propulsion system has two machines: One machine is operating mostly as a motor while the other machine is operating mostly as a generator. Both machines of the Volt electric drive system are permanent-magnet ac synchronous machine types with the magnets buried inside the rotor. The motor has distributed windings. However, as opposed to a conventional stranded winding, the Chevrolet Volt motor has bar-wound construction to improve the motor performance, particularly in the low to medium speed range. At higher speed, the skin and proximity effects in the stator bars lead to increased stator winding losses but are addressed in the design. The bar-wound construction also has excellent thermal performance, in both the steady-state and transient conditions, necessary for full electric vehicle (EV) driving. The generator uses concentrated windings. The concentrated winding construction has good slot fill and short end-turn length. These features resulted in good performance in the intended operational region and were an enabler for machine packaging inside the transmission. Both the machines exhibit excellent efficiency and exceptionally smooth and quiet operation. The machine design and construction details, as well as the measured thermal, electromagnetic, and acoustic noise performances, are presented in this paper.
Plane Wave Converter for 5G Massive MIMO Basestation Measurements (2018)

Basestation antenna systems in 5G present two significant challenges for antenna measurement: up to 256 antennas and integrated transceiver with antenna, resulting in an elimination of traditional RF port interfaces and large DUTs (device under test). Several transceiver performance metrics are typically measured in far-field type conditions, including Error Vector Magnitude (EVM), Adjacent Channel Leakage Power (ACLR), and Spectral Emissions Mask (SEM). Due to the basestation size in the 5G sub 6GHz frequency bands, this requires a far-field chamber with 10 to 50 meters of range length. This paper proposes a method using a variant of a hardware based Fourier transform located in the near-field of the DUT antenna in order to create far-field conditions-a plane wave converter (PWC). A phased antenna array of 156 elements is placed within 1.5 meters of a high gain basestation antenna of dimensions 60×60 cm. There is excellent agreement between the gain measurement results of the PWC with measurement results from a certified chamber. The measurement system is bidirectional and able to directly measure both traditional antenna metrics of gain as well as transceiver metrics of EVM, ACLR, SEM, and receiver sensitivity.
ChemInform Abstract: DURCH POLYMERE GESCHUETZTE REAGENZIEN, POLYSTYROL‐ALUMINIUMCHLORID (1973)

Abstract Die Darstellung eines Lewis‐Säure‐Katalysators aus einem Polystyrol‐Divinylbenzol‐Kopolymeren und AlCl 3 wird beschrieben.
Oxidant therapy improves adipogenic differentiation of adipose-derived stem cells in human wound healing (2021)

In conclusion, the appearance of adipocytes in wound tissue indicates a prevailing anti-inflammatory environment that could be promoted by NCT treatment and may be associated with improved healing outcomes.
An Overview of Computer-Integrated Surgery and Therapy (2023)

Historically, stereotactic neurosurgery has been probably the first surgical discipline to benefit from computer-integrated surgery and therapy (CIST) technology. The fact that some accurate mechanical systems had been used for a long time (stereotactic frames) and the conjunction of the advent of CT imaging and sufficiently powerful low-cost computers may explain that phenomenon. The criteria corresponding to a given CIST system are many and dependent on the type of surgery. However, it is possible to define a list of global objectives at which any CIST system designer should aim. All the multimodality data that have been acquired must be modeled to provide appropriate representations for the subsequent steps of the perception/decision/action loop. There are two main technical issues at this level: calibration and segmentation. In many applications, using raw sensor data is usually insufficient for subsequent processing. Extraction of high-level representations such as the surface of a particular anatomical structure is very useful for registration and surgical planning steps.
Imaging Sub-micron Scale Light Confinement in Silicon Waveguides with Apertureless Transmission-based Near-field Scanning Optical Microscopy (2006)

We measure transverse optical decay lengths on the order of lambda/30 in sub-micron scale silicon waveguides using transmission-based near-field scanning optical microscopy (TraNSOM), and compare these measurements to theory
Atomic-Scale Simulation of Si Etching by Energetic Br<sup>+</sup> and Br<sub>2</sub><sup>+</sup> Ions for the Analysis of Gate- or STI- Etching Processes (2008)

2008 International Conference on Solid State Devices and Materials,Atomic-Scale Simulation of Si Etching by Energetic Br<sup>+</sup> and Br<sub>2</sub><sup>+</sup> Ions for the Analysis of Gate- or STI- Etching Processes
Data from Development of Human Anti-Murine T-Cell Receptor Antibodies in Both Responding and Nonresponding Patients Enrolled in TCR Gene Therapy Trials (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Immune responses to gene-modified cells are a concern in the field of human gene therapy, as they may impede effective treatment. We conducted 2 clinical trials in which cancer patients were treated with lymphocytes genetically engineered to express murine T-cell receptors (mTCR) specific for tumor-associated antigens p53 and gp100.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Twenty-six patients treated with autologous lymphocytes expressing mTCR had blood and serum samples available for analysis. Patient sera were assayed for the development of a humoral immune response. Adoptive cell transfer characteristics were analyzed to identify correlates to immune response.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Six of 26 (23%) patients' posttreatment sera exhibited specific binding of human anti-mTCR antibodies to lymphocytes transduced with the mTCR. Antibody development was found in both responding and nonresponding patients. The posttreatment sera of 3 of these 6 patients mediated a 60% to 99% inhibition of mTCR activity as measured by a reduction in antigen-specific interferon-γ release. Detailed analysis of posttreatment serum revealed that antibody binding was β-chain specific in 1 patient whereas it was α-chain specific in another.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; A subset of patients treated with mTCR-engineered T cells developed antibodies directed to the mTCR variable regions and not to the constant region domains common to all mTCR. Overall, the development of a host immune response was not associated with the level of transduced cell persistence or response to therapy. In summary, patients treated with mTCR can develop an immune response to gene-modified cells in a minority of cases, but this may not affect clinical outcome. &lt;i&gt;Clin Cancer Res; 16(23); 5852–61. ©2010 AACR.&lt;/i&gt;&lt;/p&gt;&lt;/div&gt;
Lithographically Cut Single-Walled Carbon Nanotubes:  Controlling Length Distribution and Introducing End-Group Functionality (2003)

Single-walled carbon nanotubes are efficiently cut to precise submicrometer lengths and very narrow length distributions. Chemical functional groups are placed selectively only at the ends without the nanotube walls being modified or damaged. The new methodology includes lithography to place protective photoresist patterns over the nanotubes and reactive ion etching to remove the unprotected nanostructure. This approach enables critical dimensional and chemical control for integrated nanodevice manufacturing based on chemical self-assembly under ambient conditions.
A 128-Channel CMOS Charge Readout ASIC for Flat-Panel X-Ray Detectors (2008)

A CMOS charge readout ASIC (SD7110) for flat-panel X-ray detectors was designed and tested. This ASIC contains 128 readout channels, with each channel consisting of a charge sensitive amplifier, a correlated double sampler, and a track-and-hold circuit. Channel outputs are read out via a 128:1 analog multiplexer and fed into an external 16-bit A/D converter. Conversion gain can be selected from 0.25 V/pC to 8 V/pC. The ASIC operates using a +5.0 V single power supply, with power dissipation of 1.8 mW/channel. The equivalent noise charge (ENC) measured was 400 + 18.9 e-/pF.
AP-1 elements and TCL1 protein regulate expression of the gene encoding protein tyrosine phosphatase PTPROt in leukemia (2011)

We previously demonstrated that the gene encoding PTPROt, the truncated form of protein tyrosine phosphatase receptor type O expressed predominantly in hematopoietic cells, is a candidate tumor suppressor and is down-regulated in chronic lymphocytic leukemia (CLL). Here, we show that PTPROt expression is significantly reduced in CD19(+) spleen B cells from Eμ-T cell leukemia 1 (TCL1) transgenic mice relative to the wild-type mice. Strikingly, as much as a 60% decrease in PTPROt expression occurs at 7 weeks independently of promoter methylation. To elucidate the potential mechanism for this early suppression of PTPROt in these mice, we explored the role of activating protein-1 (AP-1) in its expression. We first demonstrate that AP-1 activation by 12-O-tetradecanoylphorbol-13-acetate induces PTPROt expression with concurrent recruitment of c-fos and c-jun to its promoter. The PTPROt promoter is also responsive to over- and underexpression of AP-1, confirming the role of AP-1 in PTPROt expression. Next, we demonstrate that TCL1 can repress the PTPROt promoter by altering c-fos expression and c-jun activation state. Finally, using primary CLL cells we have shown an inverse relationship between TCL1 and PTPROt expression. These findings further substantiate the role of TCL1 in PTPROt suppression and its importance in the pathogenesis of CLL.
The Effects of Lung Protective Ventilation or Hypercapnic Acidosis on Gas Exchange and Lung Injury in Surfactant Deficient Rabbits (2016)

Whereas hypercapnic acidosis may have some beneficial effects, a significant effect on lung injury and systemic inflammatory response is dependent upon a lower tidal volume rather than resultant arterial CO2 tensions and pH alone.
Abstract C202: Targeting the mitotic checkpoint for cancer therapy with NMS-P715, a novel MPS1 kinase inhibitor (2009)

Abstract The Spindle Assembly Checkpoint (SAC) is a mitotic mechanism specifically required for proper chromosomal segregation ensuring that cells do not divide until all sister chromatids correctly align to the metaphase plate. MPS1 kinase, (also known as TTK) is a key regulator of SAC functions and it has been found to be up-regulated in a number of tumors of different origins. The hypothesis is that SAC activity could be highly required to sustain aneuploid tumor growth and MPS1 inhibitors may have a therapeutic benefit in the treatment of certain cancers. We have identified NMS-P715, a potent and selective oral bioavailable small-molecule MPS1 kinase inhibitor with an ATP-competitive bindingmode. Treatment of cells with NMS-P715 accelerates mitotic exit with an IC50 of 53 nM. This is accompanied by reduction of the mitotic length, MPS1 dephosphorylation, chromosomal mis-alignment, delocalization of kinetochore components and massive aneuploidization, which ultimately leads to cell death. Proliferation data performed on a large panel of 126 cell lines shows a wide range of activity and indicates selective activity against tumoral cells compared to normal cells. Oral administration of NMS-P715 in tumor xenografted mice resulted in potent tumor growth inhibition in an ovarian cancer xenograft model and was accompanied by biomarker modulation, confirming the expected MOA. Our data provide evidence that inhibition of MPS1 kinase and SAC abrogation could represent a new promising approach to cancer therapy. Citation Information: Mol Cancer Ther 2009;8(12 Suppl):C202.
High resolution parameter estimation for ultra-wideband MIMO radar (2010)

In this paper, remote vital sign detection using UWB MIMO radar is investigated. The UWB MIMO channel, which includes the test subject as well as other objects, is modeled as a superposition of propagation paths. Estimation of the path parameters, such as delays and directions, allows to identify and track the breathing pattern, and enable the localization of the target. Modification of the high-resolution RIMAX algorithm (iterative maximum-likelihood estimation scheme) together with a path detection scheme, enables estimation of delay variations of the diaphragm-reflected paths, that are much smaller than the Fourier resolution limits. Furthermore, it is illustrated that with a wideband array model, the requirements for antenna spacing are not as limited as for conventional narrowband array processing. The concept is demonstrated through a controlled experiment using an artificial “breathing” object in an anechoic chamber.
Supplementary Figure 2 from Systems Analysis of the NCI-60 Cancer Cell Lines by Alignment of Protein Pathway Activation Modules with “-OMIC” Data Fields and Therapeutic Response Signatures (2023)

&lt;p&gt;PDF file - 150K, Identification and characterization of activated pathway modules by signal transduction representation: IGF-1R (A), apoptosis (C), mTOR (E), AKT (G) and EGFR (I) and unsupervised hierarchical clustering: IGF-1R (B), apoptosis (D), mTOR (F), AKT (H) and EGFR (J). For the pathway representation, the inhibitory phosphorylations considered in the analysis are shown in red and the activating phosphorylations in green. For the unsupervised hierarchical clustering, the complete panel of NCI-60 (vertical axis) is shown. Specific endpoint relative intensity values have been used to create the heatmaps. After overall score calculation, we highlighted the cell lines with the top 10 pathway scores (red), and the cell lines with the lowest 10 pathway activation scores (green).&lt;/p&gt;
A Java applet for visualizing protein–protein interaction (2001)

The Java applet is available at http://www.charite.de/bioinformatics
Towards an Understanding of Real-time Captioning on Head-worn Displays (2020)

Automatic speech recognition has made live captioning possible on mobile devices for people with hearing difficulties. In what situations is it advantageous to display the transcription on a head worn display (HWD) versus a mobile phone? Based on iterative design efforts for an on-going user study, we demonstrate the use of HWDs versus a mobile phone for captioning while a participant’s hearing is blocked using noise-canceling headphones. In the past, to compare the efficacy of the Vuzix Blade HWD to a mobile phone, eight participants attempted a toy block assembly task guided by captioning of a live instructor’s speech. The HWD had higher mental, physical and overall workload scores than the phone, potentially due to the blurriness of the HWD’s image. Re-running the experiment with Google Glass Enterprise Edition 2 HWD (above line-of-sight) with another twelve participants resulted in higher mental, effort, frustration, and overall workload scores than the phone. While Glass has a much sharper image than the Blade, the speech recognition quality was significantly worse. However, nine of the twelve participants stated that they would prefer Glass for the task if the speech recognition was better. Current efforts replace live speech recognition with a simulation of perfect recognition and improve display quality in order to more directly compare captioning on a mobile phone, a line-of-sight HWD, and an above line-of-sight HWD.
ENGENHARIA DE PRODUÇÃO EAD NO CEFETRJ DESAFIOS E RESULTADOS EM UM ANO DE COVID-19 (2021)

O consórcio Cederj leva a Educação à Distância (EAD) ao Estado do Rio de Janeiro desde o ano 2000. O consórcio vem se expandindo consistentemente desde sua criação, e reúne uma série de universidades atuantes no Estado do Rio de Janeiro, também ofertando mais de uma dezena de cursos atualmente, com um importante papel social inclusivo. O curso de Engenharia de Produção EAD do consórcio, iniciado em 2015, também segue em expansão até os dias atuais, reunindo um número cada vez maior de polos e alunos ativos. Tal curso é gerenciado em parceria pelo Centro Federal de Educação Tecnológica Celso Suckow da Fonseca (CEFET/RJ) e pela Universidade Federal Fluminense (UFF). Desde o início de 2020 a gestão do curso de Engenharia de Produção EAD proporcionava tarefas bastante desafiadoras, muito por conta das fortes chuvas que atingiram o Estado do Rio de Janeiro e logo em seguida pela eclosão da pandemia do Covid-19. Esse trabalho lança foco sobre a parcela da gestão do curso desempenhada pelo CEFET/RJ nesse cenário desafiador. Assim sendo, o objetivo é apresentar um relato de processos do curso de Engenharia de Produção EAD do CEFET/RJ que foram adaptados durante o ano da pandemia do Covid-19 (ano de 2020), e mostrar resultados relevantes que o curso obteve. O principal resultado obtido foi o redesenho de processos, e as implementações com sucesso, de forma a viabilizar o andamento regular do curso dos alunos mesmo durante a pandemia. Com o andamento regular, foi possível que o curso seguisse expandido seu quantitativo total de alunos e mantendo seu percentual de alunos ativos (inscritos em disciplinas). Inclusive, destaca-se a nota máxima 5 obtida pelo curso no último Exame Nacional de Desempenho dos Estudantes (ENADE)
Figure S2 from Neuregulin 1 Allosterically Enhances the Antitumor Effects of the Noncompeting Anti-HER3 Antibody 9F7-F11 by Increasing Its Binding to HER3 (2023)

&lt;p&gt;Supplemental Fig.S2. 9F7-F11 is a positive-allosteric modulator of NRG1 binding to HER3. NRG1 does not compete with 9F7-F11, differently from what observed with H4B-121 and MAB3481, and NRG1 binding to HER3 increases in the presence of 9F7-F11. SNAP-Tag Lumi4TM-Tb HER3-expressing HEK cells were co-incubated with various concentrations of unlabeled antibodies and 20nM d2-conjugated NRG1. After 5h30 incubation, the time-resolved fluorescence (665 nm/620 nm emission delta ratio) of NRG1-d2 binding to HER3 was measured on a Pherastar reader and normalized to 100% binding (antibody-d2 conjugates without NRG1, or NRG1-d2 conjugates without antibodies). Data were plotted using the GraphPad Prism software.&lt;/p&gt;
ragamAI: A Network Based Recommender System to Arrange a Indian Classical Music Concert (2019)

South Indian classical music (Carnatic music) is best consumed through live concerts. A carnatic recital requires meticulous planning accounting for several parameters like the performers' repertoire, composition variety, musical versatility, thematic structure, the recital's arrangement, etc. to ensure that the audience have a comprehensive listening experience. In this work, we present ragamAI a novel machine learning framework that utilizes the tonic nuances and musical structures in the carnatic music to generate a concert recital that melodically captures the entire range in an octave. Utilizing the underlying idea of playlist and session-based recommender models, the proposed model studies the mathematical structure present in past concerts and recommends relevant items for the playlist/concert. ragamAI ensembles recommendations given by multiple models to learn user idea and past preference of sequences in concerts to extract recommendations. Our experiments on a vast collection of concert show that our model performs 25%-50% better than baseline models. ragamAI's applications are two-fold. 1) it will assist musicians to customize their performance with the necessary variety required to sustain the interest of the audience for the entirety of the concert 2) it will generate carefully curated lists of south Indian classical music so that the listener can discover the wide range of melody that the musical system can offer.