gebhart/patrepeval huggingface dataset:
Retraction of “Collateral Sensitivity of Multidrug-Resistant Cells to the Orphan Drug Tiopronin” (2020)

ADVERTISEMENT RETURN TO ISSUEPREVRetractionNEXTORIGINAL ARTICLEThis notice is a retraction.Retraction of "Collateral Sensitivity of Multidrug-Resistant Cells to the Orphan Drug Tiopronin"Andrew S. GoldsboroughAndrew S. GoldsboroughMore by Andrew S. Goldsborough, Misty D. HandleyMisty D. HandleyMore by Misty D. Handley, Andres E. DulceyAndres E. DulceyMore by Andres E. Dulcey, Kristen M. PluchinoKristen M. PluchinoMore by Kristen M. Pluchino, Pavitra KannanPavitra KannanMore by Pavitra Kannan, Kyle R. BrimacombeKyle R. BrimacombeMore by Kyle R. Brimacombe, Matthew D. HallMatthew D. HallMore by Matthew D. Hall, Gary GriffithsGary GriffithsMore by Gary Griffiths, and Michael M. Gottesman*Michael M. GottesmanMore by Michael M. GottesmanCite this: J. Med. Chem. 2020, 63, 3, 1443Publication Date (Web):February 4, 2020Publication History Published online4 February 2020Published inissue 13 February 2020https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b01794https://doi.org/10.1021/acs.jmedchem.9b01794retractionACS PublicationsCopyright © 2020 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views1904Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (172 KB) Get e-Alertsclose Get e-Alerts
Heat Transfer Enhancement in Narrow Diverging Channels (2012)

Detailed heat transfer coefficient distributions have been obtained for narrow diverging channels with and without enhancement features. The cooling configurations considered include rib turbulators and concavities (or dimples) on the main heat transfer surfaces. All the measurements are presented at a representative Reynolds number of 28,000. Pressure drop measurements for the overall channel are also presented to evaluate the heat transfer enhancement geometry with respect to pumping power requirements. The test models were studied for wall heat transfer coefficient measurements using the transient liquid crystal technique. The model wall inner surfaces were sprayed with thermochromic liquid crystals, and a transient test was used to obtain the local heat transfer coefficients from the measured color change. Analysis of results shows that choice of designs is limited by available pressure drop even if the design provides significantly higher heat transfer coefficients. Dimpled surfaces provide appreciably high heat transfer coefficients and reasonable pressure drop whereas ribbed ducts provide significantly higher heat transfer coefficients and higher overall pressure drop.
Neural Mini-Apps as a Tool for Neuromorphic Computing Insight (2022)

Neuromorphic computing (NMC) is an exciting paradigm seeking to incorporate principles from biological brains to enable advanced computing capabilities. Not only does this encompass algorithms, such as neural networks, but also the consideration of how to structure the enabling computational architectures for executing such workloads. Assessing the merits of NMC is more nuanced than simply comparing singular, historical performance metrics from traditional approaches versus that of NMC. The novel computational architectures require new algorithms to make use of their differing computational approaches. And neural algorithms themselves are emerging across increasing application domains. Accordingly, we propose following the example high performance computing has employed using context capturing mini-apps and abstraction tools to explore the merits of computational architectures. Here we present Neural Mini-Apps in a neural circuit tool called Fugu as a means of NMC insight.
Vertical seismic profile migration velocity analysis via residual moveout in receiver domain common image gathers (2015)

ABSTRACT The success of imaging vertical seismic profile (VSP) data critically depends upon obtaining and using an accurate subsurface velocity model. First-arrival-time tomography can be used to derive velocities above the receivers. Reflection time tomography can be used to derive velocities below the receivers, but it requires reflection time picking and association with appropriate horizons. We described an alternative, faster way to perform velocity analysis by assessing the residual moveout after migrating walk-away VSP data. We have derived residual moveout equations for migrated common receiver gathers assuming a constant velocity model with a single horizontal reflector. The observed residual moveout in common image gathers in the receiver domain will be aligned and flat if the migration velocity is correct. If the residual moveout is not flat, by digitizing the extreme point on the unstacked, migrated traces in each common receiver gather, we could invert for the velocity of the target layer using our new residual moveout equations. We then extended this method to handle depth and laterally varying layer geometries using an iterative root-mean-square velocity scheme and a layer-stripping strategy. We combined the power of a prestack VSP depth migration using complicated velocity structures with straightforward velocity updating equations. For a range of synthetic cases and geometries, the estimated velocities were within 3% of the actual value.
Improving the Speed of Virtual Rear Projection: A GPU-Centric Architecture (2006)

Projection is the only viable way to produce very large displays. Rear projection of large-scale upright displays is often preferred over front projection because of the lack of shadows that occlude the projected image. However, rear projection is not always a feasible option for space and cost reasons. Recent research suggests that many of the desirable features of rear projection, in particular lack of shadows, can be reproduced using active virtual rear projection (VRP). We present a new approach to shadow detection that addresses limitations with previous work. Furthermore, we demonstrate how to exploit the image processing capabilities of a GPU to shift the main performance bottleneck from image processing to camera capture and projector display rates. The improvements presented in this paper enable a speed increase in image processing from 15Hz to 110Hz in our new active VRP prototype.
Novel mobile TFT‐LCDs based on SLS technology (2007)

Abstract— Single‐crystal‐like silicon (SLS) technology is the most cost‐effective laser‐crystallization process ever invented. The throughput of the SLS process is about two times higher than that of the conventional excimer‐laser annealing (ELA) method. In addition, the performance of the TFTs fabricated by the SLS process is among the best utilized in mass production. Various TFT‐LCDs employing SLS technology, which included a 1.02‐in. full SOG LCD using an icon display for the sub‐display of cellular phones, a 1.9‐in. qVGA TFT‐LCD with a low‐power analog interface employing a low‐voltage driving scheme, and a 3.0‐in. VGA TFT‐LCD compatible with the 480i data format without additional signal processing were developed. Because the SLS process enables us to achieve highly uniform and reliable transistors, it can be effectively utilized in the mass production of mobile TFT‐LCDs with low power consumption and enhanced image quality.
Feedforward Controller of Ill-Conditioned Hysteresis Using Singularity-Free Prandtl–Ishlinskii Model (2009)

Piezoelectric, magnetostrictive, and shape memory alloy actuators are gaining importance in high-frequency precision applications constrained by space. Their intrinsic hysteretic behavior makes control difficult. The Prandtl-Ishlinskii (PI) operator can model hysteresis well, albeit a major inadequacy: the inverse operator does not exist when the hysteretic curve gradient is not positive definite, i.e., ill condition occurs when slope is negative. An inevitable tradeoff between modeling accuracy and inversion stability exists. The hysteretic modeling improves with increasing number of play operators. But as the piecewise continuous interval of each operator reduces, the model tends to be ill-conditioned, especially at the turning points. Similar ill-conditioned situation arises when these actuators move heavy loads or operate at high frequency. This paper proposes an extended PI operator to map hysteresis to a domain where inversion is well behaved. The inverse weights are then evaluated to determine the inverse hysteresis model for the feedforward controller. For illustration purpose, a piezoelectric actuator is used.
A Comparative Study Of Dopant Activation And Deactivation In Arsenic and Phosphorus Implanted Silicon (2011)

Comparative As and P beamline implantations were subjected to a series of low, high, low, high anneals and evaluated after each step. Following high temperature anneals, there is an increase in carrier concentration, a decrease in mobility, and an increase in the concentration of mobility scattering defects.
Carbonate Reservoir Rocks Show Induced Polarization Effects, Based on Generalized Effective Medium Theory (2013)

The analysis of electrical induced polarization (IP) effects has a growing interest in oil and gas exploration. Recent electromagnetic surveys in Saudi Arabia revealed resistivity dispersive variations in agreement with fluid distribution in the surveyed reservoirs. This paper demonstrates that two selected carbonate reservoir formations, typical of Saudi Arabia, show in the laboratory distinct IP responses that are statistically repeatable. Reservoir rocks saturated with crude oil are observed to have different and distinct complex resistivity (CR) spectra than the same reservoir rocks saturated with brine. Therefore, IP methods have the potential to provide a basis for in situ fluid discrimination. We demonstrate also that using the analysis based on Generalized Effective Medium Theory of Induced Polarization (GEMTIP) one can invert the observed CR spectra for meaningful rock and fluid properties, such as fluid saturations and porosity. GEMTIP based inversion also recovers the resistivities of the fluids in the rock samples, thereby becoming feasible to produce 3D models of porosity and fluid (oil and water) saturations from the 3D models of resistivity and chargeability, as recovered from the GEMTIP based 3D inversion of the large scale field IP data.
Idiopathic Multicentric Castleman Disease Presenting With Hypertensive Choroidopathy: A Case Report (2023)

Castleman disease (CD) is a lymphoproliferative disorder and rarely affects ocular tissue. This study aimed to report a case of hypertensive choroidopathy in a patient with Castleman's disease associated with malignant hypertension. A 39-year-old man visited his local physician with fever, systemic edema, and multiple lymphadenopathies. An inguinal lymph node biopsy indicated CD. One month after the biopsy, the patient noted a blurring of vision. At the time of the initial examination at our hospital, his best-corrected visual acuity (BCVA) was 20/20 in both eyes but there were bilateral multiple Elschnig spots and sprinter hemorrhage at the fundus. Swept-source optical coherence tomography showed intra-retinal fluid, and serous retinal detachment (SRD). Fluorescein angiography revealed multiple punctate hyper fluorescences and indocyanine green angiography showed choroidopathy with increased vascular permeability. A general examination revealed symptoms of cardiac failure and multiple lymphadenopathies. Malignant hypertension with acute glomerulonephritis was diagnosed after a renal biopsy. After antihypertensive treatment, his blood pressure (BP) improved, and the SRD and choroidopathy promptly resolved. Presently, the patient is being followed up without complications. We report a case of hypertensive choroidopathy in a patient with CD associated with malignant hypertension. As a severe elevation in BP can damage choroidal vasculature and lead to vision loss, careful observation and active treatment are necessary.
Crystalline thin‐foil silicon solar cells: where crystalline quality meets thin‐film processing (2012)

ABSTRACT Crystalline Si (c‐Si) technology is dominating the photovoltaics market. These modules are nonetheless still relatively expensive, in particular because of the costly silicon wafers, which require large thickness mostly to ease handling. Thin‐film technologies, on the other hand, use much less active material, exhibit a much lower production cost per unit area, but achieve an efficiency still limited on module level, which increases the total system costs. A meet‐in‐the‐middle is possible and is the object of this paper. The development of c‐Si thin‐foil modules is presented: first, the fabrication of the active material on a glass module and then the processing of the Si foils into solar cells, directly on module level. The activity of IMEC in this area is put into perspective with regard to worldwide research results. It appears that great opportunities are offered to this cell concept, although some challenges still need to be tackled before cost‐effective and reliable industrial production can be launched. Copyright © 2012 John Wiley &amp; Sons, Ltd.
DNAReplication: Mammalian (2014)

Abstract Deoxyribonucleic acid (DNA) replication is an evolutionarily semi‐conserved process that involves a mechanism to unwind the parent DNA strand, the synthesis of identical daughter strands, and steps to terminate the sequence. Owing to the massive amount of genetic information needed to be copied error‐free, the replication of DNA within the mammalian chromosome is highly complex, requiring the simultaneous firing of multiple origins and processing of DNA at defined sites within the cells. This action requires the strict regulation and precise timing of numerous proteins, enzymes and substrates. These components critical to DNA replication will associate within these compartments in the cell to form replication factories during processing. Although many of the basic functions of DNA synthesis are well‐defined, there is still much yet to be understood regarding the machinery involved in the initiation, synthesis and termination of mammalian DNA replication. Key Concepts: Mammalian DNA replication occurs at specific regions within the cell. Proteins necessary for DNA replication come together to form ‘replication factories’ within the nucleus. The manner and timing of mammalian DNA replication is largely determined in G1 of the cell cycle. The selection and timing of each replication site is controlled by a combination of primary sequences, kinase activation, transcription, and local chromatin environment. The proteins thus far identified at the mammalian cell DNA replication fork include the MCM helicase complex, DNA pol α‐primase, PCNA, RFC, DNA pol δ, FEN1, RPA, DNA ligase I, topoisomerase I and II and RNAse H. Termination of mammalian DNA replication is thought to be dependent on physical barriers within the replication factories, as opposed to actual termination sequences within the DNA structure. In the event of replication fork stalling, repair pathways must be activated to halt cell cycle progression and repair the damage.
ChemInform Abstract: Synthesis and Protein Kinase C Binding Activity of Benzolactam‐V7. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
An Approach to Online Identification of Takagi-Sugeno Fuzzy Models (2004)

An approach to the online learning of Takagi-Sugeno (TS) type models is proposed in the paper. It is based on a novel learning algorithm that recursively updates TS model structure and parameters by combining supervised and unsupervised learning. The rule-base and parameters of the TS model continually evolve by adding new rules with more summarization power and by modifying existing rules and parameters. In this way, the rule-base structure is inherited and up-dated when new data become available. By applying this learning concept to the TS model we arrive at a new type adaptive model called the Evolving Takagi-Sugeno model (ETS). The adaptive nature of these evolving TS models in combination with the highly transparent and compact form of fuzzy rules makes them a promising candidate for online modeling and control of complex processes, competitive to neural networks. The approach has been tested on data from an air-conditioning installation serving a real building. The results illustrate the viability and efficiency of the approach. The proposed concept, however, has significantly wider implications in a number of fields, including adaptive nonlinear control, fault detection and diagnostics, performance analysis, forecasting, knowledge extraction, robotics, behavior modeling.
Thyristors and triacs control by a high frequency sine signal (2004)

The aim of this paper is to present a new control mode of AC switch (thyristors, triacs ...). The applied signal on the device gate is a "high frequency" alternating sine, instead of a pulse-shaped signal. This solution has been retained in order to integrate galvanic isolation with power-controlled switches. Control by sine signal implements the accumulation of electrical charges inside the structure leading to the SCR (silicon controlled rectifier) firing. The efficiency of the gate signal is conditioned by the architecture of the semiconductor device, particularly the gate-cathode junction which has a "pilot" role in the firing. Comprehension of physical phenomena, which occur in the switch and more precisely in the gate's area, during the firing phase, allows us to adapt the control circuit or to imagine new SCR structures optimised for a high frequency control.
Fast adjustment method of spherical aberration and focus offset by elliptic equation (2013)

Fast adjustment method of spherical aberration and focus offset by elliptic equation was developed. In the case of Blu-ray disc™, spherical aberration is increased because of high NA optical system. In this paper, we introduce our new adjustment method of spherical aberration and focus offset and experimental result of the effectiveness of this method.
An unusual photo-oxidation pathway for a poly(2,6-dimethyl-1,4-phenylene oxide) model compound (2017)

The long wavelength UV photochemistry was investigated of a model compound for poly(2,6-dimethyl-1,4-phenylene oxide). Irradiation of the phenyl-capped dimer of 2,6-dimethyl phenol at wavelengths >290 nm with UVA-340 fluorescent lamps in the absence of oxygen gave no detectable products after 27 days. Very low conversion to oxidation products was found in the presence of oxygen, but about 20% conversion to products in which solvent had added to the benzylic methyl groups occurred under aerobic conditions when the solvents had readily abstractable hydrogen atoms. A mechanism is proposed involving the facile, reversible abstraction of a benzylic hydrogen by oxygen as a first step in the oxidation. The hydroperoxyl radical that is formed can abstract hydrogen atoms from 2° and 3° carbons of the solvent, and these radicals can combine with the benzylic radicals to give the solvent adducts. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017, 55, 2221–2226
Ten-Year Evolution of Retinopathy Lesions in an Older Nondiabetic Population (2012)

altered hemorrhage (Figure Repeated indocyanine green angiography did not show any hot spots. Final bestcorrected visual acuity was 20/30 after 2 months.
Pharmacological and behavioral management of some often-overlooked clozapine-induced side effects (2014)

This article reviews four of the milder but still bothersome side effects of clozapine that are fairly frequent and may have a negative impact on patients' compliance with the treatment regime. We reviewed the available literature on the rate and management of four non-life-threatening side effects of clozapine, including hypersalivation, constipation, tachycardia, and nocturnal enuresis. We found a variety of pharmacological and behavioral strategies to manage these four side effects. There is, however, no consensus on a preferred strategy to control these distressing side effects and there are no guidelines. Psychiatrists should be aware of the relatively high rate of hypersalivation, constipation, tachycardia, and nocturnal enuresis in clozapine-treated patients, of the impact that these side effects may have on patients' quality of life, and should be able to suggest management strategies to the patients.
Optical direct comparison of87Sr optical lattice clocks using a >50 km telecommunication fiber link (2011)

An <sup>87</sup>Sr-based-optical lattice clock in NICT is compared to that of The University of Tokyo using a &gt;50 km fiber link. In this work, we have demonstrated for the first time that two distant Sr lattice clocks generate the same frequency with systematic uncertainty of 0.31 Hz (7.3 &times; 10<sup>-16</sup> fractionally) for the 429 THz clock frequency.
Investigating the correlation of muscle function tests and sarcomere organization in C. elegans (2021)

Our results highlight the suitability of NemaFlex and burrowing assays for evaluating muscle physiology of C. elegans. Using these approaches, we discuss the importance of the studied sarcomere proteins for muscle function and structure. The scoring methodology we have developed enhances the utility of C. elegans as a genetic model to study muscle function.
Electrostatically-tuned Optical Filter Based on (2006)

A Tunable Fabry-Perot cavity composed of two Bragg mirrors is realized using enhanced DRIE process. Filter tuning is achieved by moving one of the mirrors using a high resolution electrostatic actuator over SOI. Measured filter response in C&L bands is presented. I. SUMMARY