gebhart/patrepeval huggingface dataset:
Multiparametric MRI of Rectal Cancer for Estimating the Response to Neoadjuvant Therapy and Postoperative As-sessment in Locally Advanced Rectal Cancer (2023)

Background: Conventional MRI gained wide acceptance in pretreatment evaluation of rectal cancer, yet Sensitivity and specificity in evaluating the response to Neoadjuvant therapy and post-operative assessment are less. Due to limitations of the conventional MRI which is based on classical morphological evaluation, the “multiparametric MRI“ was introduced comprising the addition of functional MRI sequences namely diffusion and perfusion to routine MRI. Aim: we aimed to highlight the value of conventional MRI with the addition of functional Technique by diffusion and perfusion analysis in the assessment of response to Neoadjuvant therapy and post-operative follow-up predicting the outcome of the disease. Methods: This study included 29 patients with stage II and III rectal cancer who received neoadjuvant therapy after having their baseline MRI during the period from January 2021 to January 2022. Patients had their MRI (post CRT) within 8 – 10 weeks, and then they underwent surgery in the form of anterior resection with TME or APR. Results: We found that biomarkers of functional MRI have greater potency for predicting response to neoadjuvant therapy in locally advanced rectal cancer when compared to conventional MRI sequences. Five (17.2%) patients showed complete response to neoadjuvant treatment while 8 (27.5%) patients had no response that when projected to the final pathological results gives a sensitivity of nearly 95.2% and specificity of 100%. Conclusion: Multiparametric MRI is a better tool to assess response to neoadjuvant treatment in locally advanced rectal cancer giving the patient good chances regarding tailoring the best surgical options that affect disease control and overall survival.
The use of biomarkers in wildlife fish – a technique which allows ignoring parasitism? (2009)

info:eu-repo/semantics/nonPublished
Modulatory features of the novel spider toxin μ‐TRTX‐Df1a isolated from the venom of the spider Davus fasciatus (2017)

μ-TRTX-Df1a shows potential as a new molecule for the development of drugs to treat pain disorders mediated by voltage-gated ion channels.
Technology, test and application of stack photoresistor colour sensors (2002)

Three kinds of stack arrangement photoresistor colour sensors are developed. The photoresistor are based on an amorphous hydrogenated silicon (a-Si:H) layer. Technology, test results of main performance and some application are given.
Production and Characterization of Recombinant Aspergillus fumigatus Cu,Zn Superoxide Dismutase and Its Recognition by Immune Human Sera (2000)

The Cu,Zn superoxide dismutase (SOD) of Aspergillus fumigatus has previously been purified and shown to be immunoreactive to the sera of patients with aspergillosis; however, the purification of large quantities of the enzyme for expanded immunological analysis is both difficult and time-consuming. Accordingly, a lambdaEMBL3 A. fumigatus genomic library was screened with degenerate oligonucleotides based on N-terminal amino acid sequence data; from this initial screen a 1,400-bp fragment was identified, labelled, and used to screen an A. fumigatus lambdagt11 cDNA library. A full-length cDNA encoding Cu,Zn SOD was subsequently identified and cloned. The cDNA encodes a protein of 154 amino acids, which does not have a signal peptide. The A. fumigatus Cu,Zn SOD possesses the typical metal binding ligands of fungal Cu,Zn SODs (six histidines and one aspartic acid) and has significant overall homology with Cu, Zn SODs in general. A recombinant A. fumigatus Cu,Zn SOD has been expressed in Pichia pastoris, is enzymatically active, and has biochemical and biophysical properties that are similar to those of the native enzyme. A sheep polyclonal antibody raised against purified native A. fumigatus Cu,Zn SOD was reactive to the recombinant enzyme by immunoenzyme development of Western blots. Sixty percent of serum samples from patients with A. fumigatus infections were reactive against the recombinant Cu,Zn SOD via immunoenzyme development of Western blots, indicating that the recombinant protein may be useful in the serodiagnostic identification of A. fumigatus infections.
Head Injury: A Rare Cause of Bilateral Internuclear Ophthalmoplegia (2018)

Abstract Rare case of bilateral internuclear ophthalmoplegia (INO) following head injury in 25-year-old male is being reported. The site of the lesion in the mid-brain as detected in the magnetic resonance imaging (MRI) correlates well with the clinical presentation. The patient recovered on conservative treatment with a course of dexamethasone (for brainstem contusion).
POST-CRYSTALLIZATION AND PHYSICAL AGING OF POLYPROPYLENE: MATERIAL AND PROCESSING EFFECTS (2002)

The application properties of plastic products are significantly influenced by the structural changes after conversion, resulting from a combination of post-crystallization and physical aging for semicrystalline materials. For three different types of polypropylene—homopolymer, ethylene/propylene random- and heterophasic copolymer—and two types of conversion—injection molding and cast film extrusion—the aging processes were studied extensively. The temperature level of the aging process plays a decisive role in determining the effects; atleast two important transitions can be identified with increasing temperature. Apart from that, the nature of the polymer and the type and conditions of conversion are also important. The cumulative effects of crystallization behavior of the polymer and cooling history determine the crystallinity and superstructure of the formed article, which in turn determines the aging behavior.
Heat Transfer in Scraped Surface Heat Exchangers (2014)

Abstract An den Wänden geschabte Apparate werden großtechnisch häufig als Wärmetauscher für Systeme mit Feststoffbildungen oder hohen Viskositäten eingesetzt. Bei geringen Länge/Durchmesser‐Verhältnissen hat dabei die Rückvermischung einen maßgeblichen Einfluss auf den prozessseitigen Wärmetransport. In dieser Arbeit zeigt sich, dass bei laminarem Durchfluss eines Rührbehälters mit wandschabenden Einbauten der Wärmetransport durch Erhöhung der Drehzahl reduziert wird. In dem vergleichsweise kurzen Apparat kann dieses Verhalten auf die Abhängigkeit des Wärmetransports vom Strömungsprofil zurückgeführt werden.
Determination of capsaicinoids in Capsicum species using ultra performance liquid chromatography‐mass spectrometry (2012)

In the present work, a rapid and sensitive ultra performance liquid chromatography-mass spectrometry method has been proposed for the analysis of capsaicinoids (nordihydrocapsaicin, capsaicin, dihydrocapsaicin, homocapsaicin, and homodihydrocapsaicin) present in different Capsicum samples. Extraction of capsaicinoids was carried out by liquid-liquid extraction using ethanol as an extracting solvent, while the chromatographic separation was achieved by reversed phase C(18) column with gradient mobile phase (solvent A: acetonitrile and solvent B: water with 0.1% formic acid). Under the optimum experimental conditions, the linear ranges were 0.5-50 μg/g with correlation coefficient (r(2) ) >0.999 for each capsaicinoids and detection limits were 0.15, 0.05, 0.06, 0.2, and 0.1 μg/g for nordihydrocapsaicin, capsaicin, dihydrocapsaicin, homocapsaicin, and homodihydrocapsaicin, respectively. Run-to-run and day-to-day precisions of the method with relative standard deviations <1.5% were achieved for all analyzed capsaicinoids. The robustness of the method was determined by utilizing different injection volumes of the extracts. Furthermore, to validate the system robustness, a run of high number of capsaicinoids present in different varieties of Capsicum samples was performed in this study. All the capsaicinoids were separated in a time of less than 9 min by employing the proposed method.
Design of Photoresists with Reduced Environmental Impact. 1. Water-Soluble Resists Based on Photo-Cross-Linking of Poly(vinyl alcohol) (1999)

The feasibility of a chemically amplified fully water-soluble negative-tone resist based upon the cross-linking of a poly(vinyl alcohol) (PVA) matrix resin has been demonstrated. Two-component resists incorporating PVA and (2,4-dihydroxyphenyl)dimethylsulfonium triflate as a water-soluble photoacid generator were formulated in deionized water and spin-coated onto bare silicon wafers. Negative-tone images were obtained upon irradiation at 254 nm, postbaking, and subsequent development in pure water. The two-component resist suffered from swelling during development, but improved performance was obtained through the addition of a cross-linking agent, hexamethoxymethylmelamine (HMMM). The resulting three-component, water-soluble resist was able to resolve micron-sized images using a 248 nm stepper, at a dose of ca. 200 mJ/cm2. Model studies conducted using 13C NMR monitoring with 2,4-pentanediol as a model for PVA showed that under acidic catalysis HMMM reacts to form active electrophilic species that add to the diol, affording ether linkages with concomitant liberation of methanol.
Improving Visible-Light Transparency of Drawn Melt-Crystallized Linear Polyethylenes: Influence of Molecular Weight Distribution (2017)

A series of drawn melt-crystallized linear polyethylenes (LPEs) with different molecular weight distributions (MWD = Mw/Mn) ranging from 2 to 25 are investigated with respect to the visible-light transparency. The results indicate that the MWD of the LPEs significantly influences the visible-light transparency of drawn melt-crystallized LPEs. At a high MWD, drawn melt-crystallized LPEs films are transparent and glass-like, this in contrast to the LPEs with a low MWD. A mechanism behind the observed results is proposed based on differential scanning calorimetry (DSC) analysis, small-angle X-ray scattering, wide-angle X-ray scattering, and small-angle light scattering experiments. A correlation between the molecular characteristics, especially the MWD, and the visible-light transparency of the drawn melt-crystallized LPEs is proposed.
Folded spectrum analysis using a frame-addressed deformable mirror device (1990)

A folded optical rf spectrum analyzer is described which is built around the 128 x 128 Frame- Addressed Spatial Light Modulator (FASLM). The input waveform is sampled at 32 MHz and displayed on the FASLM at a 2 KHz frame rate. A time-bandwidth product of approximately 8000 is achieved. A brief description of the device operation and optical performance is included.
The Newtonian gravitational constant: recent measurements and related studies (1997)

Improvements in our knowledge of the absolute value of the Newtonian gravitational constant, G, have come very slowly over the years. Most other constants of nature are known (and some even predictable) to parts per billion, or parts per million at worst. However, G stands mysteriously alone, its history being that of a quantity which is extremely difficult to measure and which remains virtually isolated from the theoretical structure of the rest of physics. Several attempts aimed at changing this situation are now underway, but the most recent experimental results have once again produced conflicting values of G and, in spite of some progress and much interest, there remains to date no universally accepted way of predicting its absolute value. The review will assess the role of G in physics, examine the status of attempts to derive its value and provide an overview of the experimental efforts that are directed at increasing the accuracy of its determination. Regarding the latter, emphasis will be placed on describing the instrumentational aspects of the experimental work. Related topics that are also discussed include the search for temporal variation of G and recent investigations of possible anomalous gravitational effects that lie outside of presently accepted theories.
Evaluation of Vehicle Dynamic Analysis with Kart (2003)

Dynamic analysis of an automobile is required to correspond with the result of running tests. We carried out running tests with a kart in order to measure cornering characteristics, and compared the result of running tests with the one of simulation. This paper verifies the range of simulation and the factor of disagreement between simulation and running tests.
Periodic cladding surface structures induced when recording fiber Bragg reflectors with a single pulse from a KrF excimer laser (1994)

Observations are presented of ∼1 μm deep periodic structures on the cladding surface of optical fibers which are simultaneously induced when recording first-order fiber Bragg reflectors by single pulse KrF excimer laser holographic exposure.
Personalized vaccine for advanced HCC. (2018)

TPS527 Background: The chronic inflammation and viral infection associated with HCC combined with liver tolerogenic mechanisms creates a profoundly immunosuppressive microenvironment. Modulating the microenvironment with checkpoint blockade benefits ~20% of patients. The non-responders and those with poor liver function are an unmet need. Checkpoint blockade requires effector cells to be resident within tumors. However, the majority of HCC lesions lack effector cells. Therefore, a strategy for amplifying the tumor-specific immune response, while counteracting the immunosuppressive mechanisms may provide an improved immunotherapy. Endogenous heat shock proteins (HSP) chaperone tumor neoantigens. A concentrated composition of calreticulin, hsp70, hsp90 and gr94/gp96 (CRCL) is purified from biopsy samples. In addition, a bioengineered allograft (BAG) derived from healthy blood donors with a Th1 memory phenotype, CD3/CD28-coated microbeads and high expression of CD40L has potent immunomodulatory and counter-regulatory properties. The combination of CRCL with BAG is being evaluated as a strategy to amplify tumor-specific immunity and counter-regulate the immunosuppressive microenvironment. Methods: An open-label Phase II clinical trial evaluating the safety and efficacy of CRCL+BAG vaccine in Child-Pugh A/B advanced/metastatic HCC w/o Sorafenib. Approximately 6-10 cores of tumor are collected at baseline. The tumor is lysed and CRCL purified using an isoelectric focusing technique. Subjects are primed with multiple intradermal injections of BAG cells alone to increase the titer of allo-specific Th1/Tc1 cells. Next, multiple intradermal injections of BAG+CRCL are administered to elicit increased titers of tumor-specific Th1/Tc1 cells. Subsequent intravenous infusions of BAG cells activate allo- and tumor-specific memory cells, enabling their infiltration into tumor lesions. The BAG allo-rejection response creates a type I cytokine storm which serves to down-regulate suppressor circuits. Response is evaluated by mRECIST and experimental biomarkers. Longitudinal CT scans with concurrent biopsies as well as multiple collections of PBMC and plasma permits immunomonitoring of these immune mechanisms. Clinical trial information: NCT02409524.
Influence of Input Pulse Shape on RF Generation in Nonlinear Transmission Lines (2016)

Nonlinear transmission lines (NLTLs) are nonlinear LC ladder networks that can act as a nonlinear and dispersive medium, thus allowing the generation of soliton bursts. Several papers have been published indicating that NLTLs offer a new option for pulse shaping and RF generation. In this paper, we investigated the response of an NLTL driven by three different pulse shapes: a rectangular, a half sine, and a triangular waveform. The performance of the NLTL was evaluated through time- and frequency-domain analysis of the RF signal sampled at the 29th section of a 30-section capacitive NLTL. The frequency of the generated RF signal is correlated with the shape of the input signal, whereby the output frequency can be adjusted by the amplitude-time characteristics of the pulse at the input of the capacitive NLTL. Higher frequency oscillations, around 30 MHz, were generated by the rectangular wave train due to its shorter rise time. The propagation of solitons along the NLTL is influenced by the input pulse rise time. Namely, the rectangular pulse showed smaller delay time as it had the shortest rise time (less than 10 ns). Maximum efficiency was obtained for the input pulsewidth of 150 ns under a duty cycle of 1/3 for the three pulse shapes (rectangular, half sine, and triangular), and this combination of parameters yielded the highest RF conversion efficiency of the NLTL. The capacitive NLTL showed a higher RF conversion efficiency (16.4%) when driven by the rectangular input signal.
3D Zinc Sponge Anodes: Towards Next-Generation Ni-Zn Batteries (2015)

Zinc-based batteries (e.g., Zn–air, Ag–Zn, Ni–Zn) are endowed with high specific energy (up to 400 Wh kg –1 ), high specific power, nonflammable alkaline electrolytes, and an earth-abundance of active materials. The advantages of zinc-based batteries make them the ideal energy storage solution to address the pitfalls of its battery-chemistry competitors—from the toxicity and low specific energy of Pb-acid to the flammability of Li-ion. The historical failure of zinc to be recognized as a worthy competitor to other technologies lies in its bedeviled non-rechargeability and modest zinc utilization (typically &lt;60% of theoretical discharge capacity), especially when constructed as an ad-hoc powder composited electrode. Traditionally, when Zn is oxidized to Zn 2+ during discharge, it forms zincate complexes (e.g. Zn(OH) 4 2– (aq) ) that are soluble in the alkaline electrolyte. These mobile Zn-carriers can diffuse beyond the site of generation but eventually supersaturate and precipitate as poorly conductive ZnO. The reverse step (charging) is initiated by re-dissolution of the ZnO to zincate prior to reduction back to Zn 0 . Multiple iterations of the above processes eventually lead to electronic isolation of portions of the electrode, hotspots of high-current density, and growth of short-inducing dendrites. To circumvent these problems, we design and fabricate 3D zinc "sponge" anodes that are monolithic and comprise an interpenetrating, co-continuous network of solid and void [1]. The electrode—now wired in 3D—enables low cell resistances throughout discharge that allow access to &gt;90% of the zinc [2]. The morphology of the discharged sponges reveals a uniform deposition of ZnO on the inner walls of the sponge electrode, providing a core–shell 3D structure with an 3D-wired inner Zn metallic core that is ideal for electrochemical recharge with 100% capacity retention. We have identified the Ni–Zn battery system, with its established and rechargeable NiOOH cathode, as a prime candidate to begin implementing 3D-Zn sponge electrodes towards next-generation alternatives to Pb-acid, Ni–Cd, Ni–MH, and Li-ion batteries. We present the design and fabrication of 3D-Zn sponge anodes and their cycling performance in Ni–Zn full cells, with specific emphasis on cell fabrication, electrolyte composition, and post-mortem analysis. The information, data, or work presented herein was funded in part by the Office of Naval Research and by the Advanced Research Projects Agency–Energy (ARPA–E), U.S. Department of Energy, under Award Number DE-AR-0000391; the work has been Approved for Public Release, Distribution Unlimited. [1] J.F. Parker, C.N. Chervin, E.S. Nelson, J.W. Long, D.R. Rolison, Energy Environ. Sci. 7 (2014) 1117–1124. [2] J.F. Parker, E.S. Nelson, M.D. Wattendorf, C.N. Chervin, J.W. Long, D.R. Rolison, ACS Appl. Mater. Interfaces , in the press.
Relationships between cortical, cardiac, and arousal-motor activities in the genesis of rhythmic masticatory muscle activity across sleep cycles in primary sleep bruxism children (2021)

This is the first study to suggest that the potentiation of RMMA occurrence was associated with transient arousal under cyclic sleep processes in primary SB children.
Use of a Purged FOUP to Improve H-Terminated Silicon Surface Stability Prior to Epitaxial Growth (2014)

H-terminated Si surfaces serve as the starting surface for hetero-epitaxial growth. The presence of oxygen on the wafer surface can significantly reduce the epitaxial layer quality. The oxygen present on the surface is, among others, determined by the re-oxidation of the surface during the queuing between cleaning and epitaxy. In this paper we report on the use of a N 2 -purged FOUP to reduce the re-oxidation of Si surfaces.
Commercial Frequency AC to High Frequency AC Converter with Boost-Active Clamp Bridge Single Stage ZVS-PWM Inverter (2007)

This paper presents a novel soft-switching PWM utility frequency AC to high frequency (HF) AC power conversion circuit incorporating boost-active clamp single stage inverter topology. This power converter is more suitable and acceptable for cost effective HF consumer induction heating (IH) applications. Its operating principle and the operation modes are presented using the switching mode equivalent circuits in addition to the operating voltage and current waveforms. The operating performances of this high frequency inverter using the latest IGBTs are illustrated, which includes HFAC power regulation ranges and actual efficiency characteristics based on zero voltage soft switching (ZVS) operation ranges and the power dissipation analysis as compared with those of the previously developed high frequency inverter. In addition, a dual mode selected control scheme of this high frequency inverter based on a constant frequency asymmetrical pulse width modulation (PWM) and pulse density modulation (PDM) control scheme is discussed in this paper in order to extend the soft switching operation ranges and to improve the power conversion efficiency at the low power settings. This power frequency converter practical effectiveness is substantially proved on the basis of experimental results from practical design example.
Cavity-Enhanced Emission from a Single Germanium Vacancy Center in a Diamond Membrane (2019)

We demonstrate room temperature cavity-coupling between a single GeV center in a micron-thick diamond membrane and a high-finesse fiber cavity. This system is a milestone towards the creation of an efficient spin-photon interface using novel defect centers in diamond.
Compensatory mutation in RpoC restores fitness to rifampicin-resistant multi-drug resistant Mycobacterium tuberculosis. (2012)

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A digital platform for cross-sector collaborative value networks in the circular economy (2021)

In recent years there has been a growing interest in Circular Economy (CE), which promises to reduce waste and improve sustainability. The promise of CE is to change the conventional “take–make–dispose” that causes massive waste flows based on the integration of demanufacturing and remanufacturing processes within value chains. This integration requires breaking the ”silos” of the circular chain to establish new collaborative and sustainable value networks. The paper introduces a novel digital platform for the CE, which is currently under development in the H2020 DigiPrime project. The platform is destined to facilitate seamless and trusted information exchange across circular actors, while offering a range of value-added services that enable manufacturers, remanufactures, recyclers and other actors to gain insights in the status of recycling and waste management processes. The latter facilitates the implementation of zero waste processes, along with the assessment of the performance of the circular chain. The paper introduces the architecture of the digital platform, along with its data modelling, exchange and data traceability mechanisms. It also presents a CE use case used to validate the platform.