gebhart/patrepeval huggingface dataset:
Anti-CD19 CAR T cells potently redirected to kill solid tumor cells (2020)

Abstract Successful CAR T cell therapy for the treatment of solid tumors requires exemplary CAR T cell expansion, persistence and fitness, and the ability to target tumor antigens safely. Here we address this constellation of critical attributes for successful cellular therapy by using integrated technologies that simplify development and derisk clinical translation. We have developed a CAR-CD19 T cell that secretes a CD19-anti-Her2 bridging protein. This cell therapy strategy exploits the ability of CD19-targeting CAR T cells to interact with CD19 on normal B cells to drive expansion, persistence and fitness. The secreted bridging protein potently binds to Her2-positive tumor cells, mediating CAR-CD19 T cell cytotoxicity in vitro and in vivo . Because of its short half-life, the secreted bridging protein will selectively accumulate at the site of highest antigen expression, ie. at the tumor. Bridging proteins that bind to multiple different tumor antigens have been created. Therefore, antigen-bridging CAR-CD19 T cells incorporate critical attributes for successful solid tumor cell therapy. This platform can be exploited to attack tumor antigens on any cancer.
Enhancement of the time resolution of a picosecond absorption spectrometer by selection of the duration of laser radiation pulses (1986)

A method is proposed for monitoring the relative change in the duration of picosecond pulses. This method is based on second harmonic generation. It is shown that selecting pulses according to their duration in an absorption spectrometer raises the accuracy of recording of the kinetic curve and increases the time resolution of this method. The laser radiation pulses are selected on the basis of their duration by an automated control and data acquisition system constructed using microprocessor technology.
Are all Cages Created Equal? Analysis of Cervical Cage Malfunctions Using FDA MAUDE Database (2023)

The most common cause of implant malfunction was breakage. Poly-ether-ether-ketone cages were more likely to break and migrate compared with titanium ones. Many of these implant failures occurred intraoperatively during instrumentation, which underscores the need for FDA evaluation of these implants and their accompanying instrumentation under the appropriate loading conditions before commercial approval.
Nuclear antisense effects of neutral, anionic and cationic oligonucleotide analogs (2020)

The antisense activity of oligomers with 2′-O-methyl (2′-O-Me) phosphorothioate, 2′-O-methoxyethyl (2′-O-MOE) phosphorothioate, morpholino and peptide nucleic acid (PNA) backbones was investigated using a splicing assay in which the modified oligonucleotides blocked aberrant and restored correct splicing of modified enhanced green fluorescent protein (EGFP) precursor to mRNA (pre-mRNA), generating properly translated EGFP. In this approach, antisense activity of each oligomer was directly proportional to up-regulation of the EGFP reporter. This provided a positive, quantitative readout for sequence-specific antisense effects of the oligomers in the nuclei of individual cells. Nuclear localization of fluorescent labeled oligomers confirmed validity of the functional assay. The results showed that the free uptake and the antisense efficacy of neutral morpholino derivatives and cationic PNA were much higher than that of negatively charged 2′-O-Me and 2′-O-MOE congeners. The effects of the PNA oligomers were observed to be dependent on the number of l-lysine (Lys) residues at the C-terminus. The experiments suggest that the PNA containing Lys was taken up by a mechanism similar to that of cell-penetrating homeodomain proteins and that the Lys tail enhanced intracellular accumulation of PNA oligomer without affecting its ability to reach and hybridize to the target sequence.
Electrically pumped quantum-dot lasers grown on 300 mm patterned Si photonic wafers (2022)

Monolithic integration of quantum dot (QD) gain materials onto Si photonic platforms via direct epitaxial growth is a promising solution for on-chip light sources. Recent developments have demonstrated superior device reliability in blanket hetero-epitaxy of III-V devices on Si at elevated temperatures. Yet, thick, defect management epi designs prevent vertical light coupling from the gain region to the Si-on-Insulator waveguides. Here, we demonstrate the first electrically pumped QD lasers grown by molecular beam epitaxy on a 300 mm patterned (001) Si wafer with a butt-coupled configuration. Unique growth and fabrication challenges imposed by the template architecture have been resolved, contributing to continuous wave lasing to 60 °C and a maximum double-side output power of 126.6 mW at 20 °C with a double-side wall-plug efficiency of 8.6%. The potential for robust on-chip laser operation and efficient low-loss light coupling to Si photonic circuits makes this heteroepitaxial integration platform on Si promising for scalable and low-cost mass production.
Solubility and partial molar volumes of heavy aromatic hydrocarbons in super critical carbon dioxide (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolubility and partial molar volumes of heavy aromatic hydrocarbons in super critical carbon dioxideSomenath Mitra, Juh W. Chen, and Dabir S. ViswanathCite this: J. Chem. Eng. Data 1988, 33, 1, 35–37Publication Date (Print):January 1, 1988Publication History Published online1 May 2002Published inissue 1 January 1988https://pubs.acs.org/doi/10.1021/je00051a012https://doi.org/10.1021/je00051a012research-articleACS PublicationsRequest reuse permissionsArticle Views248Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Combinatorial Library Design, Molecular Similarity, and Diversity Applications (2003)

Abstract This chapter discusses molecular similarity and diversity concepts and methods and their main applications to combinatorial library design, the selection of compound subsets, and ligand‐based “virtual screening.” Relevant medicinal chemistry applications discussed include the design of “diverse,” “representative,” and “thematic/focused/biased” libraries and subsets. The latter application is of particular relevance, in that there is a recent trend to approach drug discovery by a “target class” or “gene family” approach, such as 7‐TM G‐protein‐coupled receptors.
5 G Physical Layer (2019)

The 5G L1 design provides a capable and versatile radio design for different use cases and a large range of frequency bands. This chapter presents the 5G physical layer principles, including the mapping of the transport channel to the physical channel, 5G frame structure, and key physical layer procedures. Special emphasis is on the new features compared to Long Term Evolution (LTE), such as full support of beamforming, larger bandwidths, and a more flexible frame structure. The chapter also introduces the 5G channel coding solutions, physical layer procedures, and measurements as specified in 3GPP. The physical layer procedures with 5G have many new elements over LTE. One of the new areas is beamforming. The other key physical layer procedures are as follows: physical layer retransmission handling, power control and power sharing with dual connectivity, and timing advance. The chapter concludes with an overview of the physical layer aspects of the 5G UE capabilities.
Endoscopic, rapid near-infrared optical tomography (2006)

This is believed to be the first demonstration of near-infrared (NIR) optical tomography employed at the endoscope scale and at a rapid sampling speed that allows translation to in vivo use. A spread-spectral-encoding technique based on a broadband light source and linear-to-circular fiber bundling was used to provide endoscopic probing of many source-detector fibers for tomography as well as parallel sampling of all source-detector pairs for rapid imaging. Endoscopic NIR tomography at an 8 Hz frame rate was achieved in phantoms and tissue specimens with a 12 mm probe housing eight sources and eight detectors. This novel approach provides the key feasibility studies to allow this blood-based contrast imaging technology to be attempted in detection of cancer in internal organs via endoscopic interrogation.
Enzyme Engineering Towards Novel OP-Hydrolases Based on the Human Acetylcholinesterase Template (1996)

Abstract The System CF3I/Me3P is re-investigated and Me2PCF3, Me4P+γ, (CF3)2PMe3, Me3PI2, [Me3(CF3)P]+γ are found as products. Using CF3Br/P(NEt2)3 the phosphines R1 2PCF3 and R1P(CF3)2 (e.g. R1 = Me, iPr, NEt2) can be obtained which are precursors either for phosphoranes (e.g. 1,2λ5σ5-oxaphosphetanes) or phosphonium salts (e.g. [R1 2(Me)PCF3]+X− or [R1(Me)P(CF3)2X−]. The latter are deprotonated to furnish methylene phosphoranes R1 2(CH2=)PCF3 or R1(CH2=)P(CF3)2, reactive synthons. From CF3Br/P(NEt2)3/P(OPh)3 the phosphine P(CF3)3 is available, which turned out to be a potent electrophile. Amido phospites ROP(NEt2)2 and halides R2X (R2=CCl2CF3, X=Cl; R2=CF=CFCF3, X=F; R2=C6F5, X=Br, I; R2=C(CF3)3, X=Br; R2=SCF3, X=CF3) undergo an ARBUZOV reaction.
Familial influence on parkinsonism in a rural area of Turkey (Kızılcaboluk–Denizli): A community‐based case‐control study (2003)

This population-based study on parkinsonism in a genetically isolated community from a rural area of Turkey aimed to provide a selective evaluation of environmental and heritable risk factors. An increased prevalence of parkinsonism (4.1%) was detected in the village of Kizilcaboluk for people 65 years of age and older. This study included 36 patients with parkinsonism living in Kizilcaboluk and three times that number of age- and sex-matched people serving as controls. A questionnaire including demographic data, family history, education, occupation, data on exposures to pesticides, smoking, alcohol intake, and head trauma was administered. We found a significant association of parkinsonism cases with a positive family history in first-degree relatives (odds ratio [OR], 7.48; 95% confidence interval [CI], 2.52-22.17; P < 0.0001) and with pesticide exposure (OR, 2.96; 95% CI, 1.31-6.69; P = 0.015) compared to the control subjects. The value of genetically isolated populations for the identification of genetic risk factors for common and complex disorders has gained much attention recently because the genetic make-up of these populations is likely to be less complex than that of the general population and our findings should prompt investigations to the nature of a familial aggregation of parkinsonism in this population.
Strategies to Maintain Voltage on Long, Lightly Loaded Feeders with Widespread Residential Level 2 Plug-in Electric Vehicle Charging (2022)

Long, lightly loaded feeders serving residential loads may begin to experience voltage excursions as plug-in electric vehicle (PEV) penetration increases. Residential PEV charging tends to occur during peak-load hours on residential feeders, leading to increased peak loads and potential voltage excursions. To avoid voltage excursions, two PEV charging control strategies were investigated using the IEEE 34-bus feeder. The first strategy shifts PEV charging energy from peak hours to off-peak hours; the other strategy allows PEVs to provide reactive power support. Undervoltage excursions seen in a simulation of uncontrolled charging of 200 PEVs were improved dramatically when these two control strategies were used. The minimum voltage on the feeder improved from 0.855 pu when PEV charging was uncontrolled to 0.959 pu when both control strategies were applied together.
Synthesis and reactivity of molybdenum imido alkylidene bis-pyrazolide complexes (2010)

Reaction of Li(3,5-R(2)-pyrazolide) (R = tBu or Ph, dXpz) with Mo(NAr)(CHCMe(2)Ph)(OTf)(2)(DME) yields Mo(NAr)(CHCMe(2)Ph)(dXpz)(2) in good yield. These complexes react with alcohols or the surface silanols of silica, to yield bis-alkoxy and surface mono-siloxy alkene metathesis catalysts, respectively.
Perkin 1 Abstracts: Natural Product Synthesis (2001)

A. Gunn, S. McAteer, J. E. Milne and M. de Puit, J. Chem. Soc., Perkin Trans. 1, 2002, 15-vii DOI: 10.1039/B206710M
Distributed Mobility Anchoring (2020)

This document defines distributed mobility anchoring in terms of the
different configurations and functions to provide IP mobility support.
A network may be configured with distributed mobility anchoring
functions for both network-based or host-based mobility support
according to the needs of mobility support. In a distributed mobility
anchoring environment, multiple anchors are available for mid-session
switching of an IP prefix anchor. To start a new flow or to handle a
flow not requiring IP session continuity as a mobile node moves to a
new network, the flow can be started or re-started using an IP address
configured from the new IP prefix anchored to the new network. If the
flow needs to survive the change of network, there are solutions that
can be used to enable IP address mobility. This document describes
different anchoring approaches, depending on the IP mobility needs,
and how this IP address mobility is handled by the network.
Mechanical Modeling and Optimal Model-based Design of a Soft Pneumatic Actuator (2023)

Soft pneumatic actuators are widely used for soft grippers, which are known for their compliance as compared with traditional grippers. The generated force/torque of soft pneumatic actuators directly determines the grasping force. This paper introduces a computationally efficient soft pneumatic actuator (SPA) design methodology. The complex structure of the pneumatic actuator is approximated by a cantilever beam. The relationship between input pressure and output torque is derived by standard mechanical analysis. The design problem is formulated as a model-based optimization problem by treating the input-output mathematical model as the objective function. By solving the optimization problem, the optimal design parameters are obtained. Finite element analysis is applied to preliminarily verify the design parameters without the time-consuming fabrication of many actuators. Three soft actuators with different design parameter sets were fabricated to validate the optimal parameters. This work shows the utility of surprisingly simple calculations and assumptions for rapid parametric design studies.
Design and Synthesis of the Active Site Environment in Zeolite Catalysts for Selectively Manipulating Mechanistic Pathways (2021)

By combining kinetics and theoretical calculations, we show here the benefits of going beyond the concept of static localized and defined active sites on solid catalysts, into a system that globally and dynamically considers the active site located in an environment that involves a scaffold structure particularly suited for a target reaction. We demonstrate that such a system is able to direct the reaction through a preferred mechanism when two of them are competing. This is illustrated here for an industrially relevant reaction, the diethylbenzene-benzene transalkylation. The zeolite catalyst (ITQ-27) optimizes location, density, and environment of acid sites to drive the reaction through the preselected and preferred diaryl-mediated mechanism, instead of the alkyl transfer pathway. This is achieved by minimizing the activation energy of the selected pathway through weak interactions, much in the way that it occurs in enzymatic catalysts. We show that ITQ-27 outperforms previously reported zeolites for the DEB-Bz transalkylation and, more specifically, industrially relevant zeolites such as faujasite, beta, and mordenite.
Dynamic consequences of the fractal network of nanotube-poly(ethylene oxide) nanocomposites (2007)

Dispersions of single walled carbon nanotubes (SWNTs), with an effective aspect ratio of approximately 650 , in poly(ethylene oxide) (PEO) form fractal superstructures above their geometrical percolation and display rheological properties that follow time-temperature-composition-strain superpositioning. The concentration dependences of the elastic modulus of the network and the onset-strain for shear thinning are consistent with the short-range nature of the interactions that dominate these dispersions. The strain dependence of the damping behavior for the nanocomposites shows concentration invariance when represented against the local strain experienced by the network element, with the onset occurring at a local strain value of 0.1, similar to other nanocomposite systems dominated by weak interactions.
Correlation of the molecular structure of host materials with lifetime and efficiency of blue phosphorescent organic light-emitting diodes (2015)

Bicarbazole derivatives, 9,9'-bis(dibenzo[b,d]thiophen-2-yl)-9H,9'H-3,3'-bicarbazole (BCzDBT), 9,9'-bis(dibenzo[b,d]furan-2-yl)-9H,9'H-3,3'-bicarbazole (BCzDBF), and 9,9'-di([1,1'-biphenyl]-3-yl)-9H,9'H-3,3'-bicarbazole (BCzBP), were designed and examined as the hole transport type host materials of the tris[1-(2,4-diisopropyldibenzo[b,d]furan-3-yl)-2-phenylimidazole] (Ir(dbi)3) blue triplet emitter. BCzDBT performed better than BCzDBF and BCzBP as the hosts of Ir(dbi)3 and could demonstrate 24.8% quantum efficiency and long lifetime in the blue phosphorescent devices. Strong hole carrying properties of the bicarbazole derivatives were proposed as the main factors for the high quantum efficiency of the BCzDBT devices, and thermal and chemical stability of BCzDBT were suggested as crucial factors for the long lifetime of the BCzDBT devices.
Participatory ergonomics using VR integrated with analysis tools (2004)

This paper presents our work on the integrated use of simulation tools in real time for participatory occupational ergonomic studies. The focus of this paper is a synergistic system that consists of an interactive immersive simulation tool that has been developed in-house and integrated with a commercial human modeling simulation system, Jack/spl trade/. The impetus of the real-time integration is to allow the complementary use of two powerful simulation tools by allowing the user to perform the task naturally in an immersive environment, while the body posture information is continuously and automatically passed to the human modeling system for a continuous (and not discrete) analysis of the participatory ergonomic issues under consideration. This facilitates integration of ergonomic issues early in the design and planning phases of workplace layouts, even where the physical facility does not exist. The proposed integration is demonstrated using a manufacturing example.
Hybrid Poly(aryl ether sulfone amide)s for Advanced Thermoplastic Composites (2014)

An organocatalytic approach to the depolymerization of poly(ethylene terephthalate) (PET) with selected nucleophiles generates high‐value terephthalate‐based monomers. These monomers are subjected to nucleophilic aromatic substitution (S N Ar) polymerizations in order to circumvent many of the traditional drawbacks of unmodified materials such as poly(aryl ether sulfone)s (PESs). The synthesis and molecular characterization of novel poly(aryl ether sulfone‐amide)s (PAESAs) containing 10–30 wt% amide functionality are described. PAESAs containing 30 wt% amide are fabricated via extrusion and solvent casting for mechanical characterization. The mechanical behavior of the extruded PAESA is studied through dynamic mechanical analysis (DMA) and tension tests. The DMA studies are performed at a frequency of 1 Hz, in the temperature range of 22–275 °C, indicating a storage modulus of 2.77 ± 0.58 MPa at 30 °C. The glass transition temperature ( T g ) of the material, as the temperature corresponding to tan δ peak, is measured to be 217.1 ± 1.7 °C, consistent with DSC measurements. The tension tests on extruded samples reveal a ductile fracture, evidenced with neck formation and propagation on the macroscale, and a rough fracture surface on the microscale. The yield strength of the sample is found to be 52.8 ± 9.2 MPa, with a ductility ranging from 6% to 11%. In contrast to extruded samples, the solvent‐cast PAESA samples fail in a brittle fashion, with relatively smooth fracture surface and no sign of necking. image
"Good enough" software reliability estimation plug-in for Eclipse (2003)

Programmers who use the test-driven development practice of the Extreme Programming methodology write extensive automated unit and acceptance tests. This paper describes an Eclipse plug-in that utilizes the results of this automated testing, and in combination with a suite of internal product metrics, provides an early assessment of product reliability. We discuss the correlation between the metrics we use and the reliability of the developed software, as well as the general functional characteristics of the alpha version of our Eclipse plug-in.
Rate of Convergence in Density Estimation Using Neural Networks (1996)

Given N i.i.d. observations {X i } N i=1 taking values in a compact subset of R d , such that p * denotes their common probability density function, we estimate p * from an exponential family of densities based on single hidden layer sigmoidal networks using a certain minimum complexity density estimation scheme. Assuming that p * possesses a certain exponential representation, we establish a rate of convergence, independent of the dimension d, for the expected Hellinger distance between the proposed minimum complexity density estimator and the true underlying density p * .
Autoregulation of Helicobacter pylori Fur revealed by functional analysis of the iron‐binding site (2002)

The ferric uptake regulator protein Fur regulates iron-dependent gene expression in bacteria. In Helicobacter pylori it has been shown to regulate iron-activated and iron-repressed genes. In this study, we show that H. pylori Fur protein regulates transcription from its own sigma 80 promoter P fur in response to iron. Footprinting analysis shows that Fur binds at three distinct operators at P fur overlapping and proximal to the promoter elements. Site-directed mutagenesis of the proposed iron-binding site of the protein results in derepression of P fur and the loss of iron regulation. In vivo oligomerization assays reveals that the C-terminus of Fur is necessary for multimerization of the protein and that the mutations do not affect this activity. Molecular and phenotypic analysis of the mutant proteins provides evidence that the iron-binding site controls the specific affinity of Fur for the operators at P fur and hence its repressive ability. In summary, the data presented are consistent with a model in which Fur acts as a rheostat of transcription to autoregulate its own expression in response to iron, which in turn controls expression of iron-induced and iron-repressed genes, providing maintenance of homeostasis.