gebhart/patrepeval huggingface dataset:
Combined IgE neutralization and Bifidobacterium longum supplementation reduces the allergic response in models of food allergy (2022)

IgE is central to the development of allergic diseases, and its neutralization alleviates allergic symptoms. However, most of these antibodies are based on IgG1, which is associated with an increased risk of fragment crystallizable-mediated side effects. Moreover, omalizumab, an anti-IgE antibody approved for therapeutic use, has limited benefits for patients with high IgE levels. Here, we assess a fusion protein with extracellular domain of high affinity IgE receptor, FcεRIα, linked to a IgD/IgG4 hybrid Fc domain we term IgE<sub>TRAP,</sub> to reduce the risk of IgG1 Fc-mediated side effects. IgE<sub>TRAP</sub> shows enhanced IgE binding affinity compared to omalizumab. We also see an enhanced therapeutic effect of IgE<sub>TRAP</sub> in food allergy models when combined with Bifidobacterium longum, which results in mast cell number and free IgE levels. The combination of IgE<sub>TRAP</sub> and B. longum may therefore represent a potent treatment for allergic patients with high IgE levels.
Proangiogenic Properties of Thrombospondin-4 (2015)

TSP-4, an extracellular matrix protein previously associated with tissue remodeling, is now demonstrated to possess proangiogenic activity.
Le député débutant (2016)

Cet article se focalise sur les differentes facettes du processus d’apprentissage du mandat de depute auxquelles sont confrontes les nouveaux elus allemands qui decouvrent le Bundestag. S’appuyant sur un protocole empirique ethnographique mis en place durant les premieres semaines du mandat d’un nouvel elu CDU/CSU, cet article montre que l’assimilation de l’ethos parlementaire est un processus chaotique durant lequel interviennent de nombreux acteurs, parfois exterieurs au Bundestag. L’observation fait apparaitre que c’est durant ces premieres semaines que s’operent des mecanismes de distinction bases sur les proprietes des nouveaux arrivants. Tres rapidement, le role et la position de chacun sont ainsi etablis au sein de l’institution parlementaire.
Treatment with 5-azacytidine induces a sustained response in patients with angioimmunoblastic T-cell lymphoma (2018)

TO THE EDITOR:

Peripheral T-cell lymphomas (PTCLs) are heterogeneous diseases resulting from the malignant transformation of mature T or natural killer cells. Their epidemiology varies widely, but PTCLs that derive from T follicular helper (TFH) cells, which include angioimmunoblastic T-cell
The Effects of Passive Cycling on Tremor and Motor Function in Individuals with Parkinson's Disease (2010)

Research has shown that exercise can improve tremor and motor function in individuals with Parkinson's disease. However symptoms of Parkinson's disease may hinder one's ability to perform voluntary exercise. PURPOSE: The purpose of the current investigation was to determine if passive cycling at different pedaling rates improves tremor and motor function in Parkinson's subjects. METHODS: Nineteen, mild to moderate idiopathic Parkinson's subjects (12 men, 7 women, age 63.2 ± 8.6 yr), reported to the exercise science laboratory on four separate occasions, separated by one week. On the first visit, the Parkinson's subjects completed a YMCA cycling test to estimate maximal oxygen consumption. A computer based Kinesia program that tested tremor and bradykinesia and an Automated Movement Analysis System (7-test) was completed. For the next three visits, Parkinson's subjects participated in passive leg cycling (MOTOmed viva2) at 60, 70 or 80 revolutions per minute (rpm) while 'off' anti-Parkinson's medications. Cycling rates were randomized. The Kinesia tests and the 7-test were administered prior to and immediately after each cycling session. RESULTS: Data was analyzed using a 3 (Trial) by 2 (Time) analysis of variance (ANOVA) with repeated measures on all variables. 7-test scores of total distance did not differ between trials or across time. A main effect for time was observed for 7-test scores of time to completion (p < 0.01). There were no main effects of trial or trial by time interaction for 7-test scores of time to completion. Kinesia scores of peak frequency improved tremor following passive cycling (p ≤ 0.02). There were no main effects of trial or trial by time interaction for peak frequency. There was a significant decrease in postural and resting tremor scores with time. Movement frequency increased with time in all the bradykinesia tasks. CONCLUSION: These data suggest that passive cycling does improve tremor and motor function in individuals with Parkinson's disease. Furthermore, this study shows that lower extremity passive cycling can improve motor function in the upper extremity.
Detection of boson peak and fractal dynamics of disordered systems using terahertz spectroscopy (2020)

The boson peak is a largely unexplained excitation found universally in the terahertz vibrational spectra of disordered systems; the so-called fracton is a vibrational excitation associated with the self-similar structure of monomers in polymeric glasses. We demonstrate that such excitations can be detected using terahertz spectroscopy. In the case of fractal structures, we determine the infrared light-vibration coupling coefficient for the fracton region and show that information concerning the fractal and fracton dimensions appears in the exponent of the absorption coefficient. Finally, using terahertz time-domain spectroscopy and low-frequency Raman scattering, we experimentally observe these universal excitations in a protein (lysozyme) system that has an intrinsically disordered and fractal structure and argue that the system should be considered a single supramolecule. These findings are applicable to amorphous and fractal objects in general and will be valuable for understanding universal dynamics of disordered systems via terahertz light.
Supplementary Tables from Integrative Radiogenomic Profiling of Squamous Cell Lung Cancer (2023)

&lt;p&gt;PDF file, 109K, Clonogenic survival of lung SqCC after radiation (S1); High-throughput profiling of lung SqCC after radiation (S2); Mutations in NFE2L2 and KEAP1 in lung SqCC cell lines (S3); MSigDB Gene Sets from Fig S5 (S4); TP53 alterations, LOH, and mRNA levels in lung SqCC cell lines (S5).&lt;/p&gt;
Microwave Heating of Functionalized Graphene Nanoribbons in Thermoset Polymers for Wellbore Reinforcement (2016)

Here, we introduce a systematic strategy to prepare composite materials for wellbore reinforcement using graphene nanoribbons (GNRs) in a thermoset polymer irradiated by microwaves. We show that microwave absorption by GNRs functionalized with poly(propylene oxide) (PPO-GNRs) cured the composite by reaching 200 °C under 30 W of microwave power. Nanoscale PPO-GNRs diffuse deep inside porous sandstone and dramatically enhance the mechanics of the entire structure via effective reinforcement. The bulk and the local mechanical properties measured by compression and nanoindentation mechanical tests, respectively, reveal that microwave heating of PPO-GNRs and direct polymeric curing are major reasons for this significant reinforcement effect.
Channel Characteristics for Terahertz Wireless Communications (2018)

We investigate channel performances for indoor terahertz (THz) wireless links with carrier frequencies at 100, 200, 300 and 400 GHz. We demonstrate error-free data links using both line-of-sight and non-line-of-sight configurations.
Evaluation of static and dynamic perfusion cardiac computed tomography for quantitation and classification tasks (2016)

Cardiac computed tomography (CT) acquisitions for perfusion assessment can be performed in a dynamic or static mode. Either method may be used for a variety of clinical tasks, including (1) stratifying patients into categories of ischemia and (2) using a quantitative myocardial blood flow (MBF) estimate to evaluate disease severity. In this simulation study, we compare method performance on these classification and quantification tasks for matched radiation dose levels and for different flow states, patient sizes, and injected contrast levels. Under conditions simulated, the dynamic method has low bias in MBF estimates (0 to [Formula: see text]) compared to linearly interpreted static assessment (0.45 to [Formula: see text]), making it more suitable for quantitative estimation. At matched radiation dose levels, receiver operating characteristic analysis demonstrated that the static method, with its high bias but generally lower variance, had superior performance ([Formula: see text]) in stratifying patients, especially for larger patients and lower contrast doses [area under the curve [Formula: see text] to 96 versus 0.86]. We also demonstrate that static assessment with a correctly tuned exponential relationship between the apparent CT number and MBF has superior quantification performance to static assessment with a linear relationship and to dynamic assessment. However, tuning the exponential relationship to the patient and scan characteristics will likely prove challenging. This study demonstrates that the selection and optimization of static or dynamic acquisition modes should depend on the specific clinical task.
Application of nano‐radiosensitizers in combination cancer therapy (2023)

Radiosensitizers are compounds or nanostructures, which can improve the efficiency of ionizing radiation to kill cells. Radiosensitization increases the susceptibility of cancer cells to radiation-induced killing, while simultaneously reducing the potentially damaging effect on the cellular structure and function of the surrounding healthy tissues. Therefore, radiosensitizers are therapeutic agents used to boost the effectiveness of radiation treatment. The complexity and heterogeneity of cancer, and the multifactorial nature of its pathophysiology has led to many approaches to treatment. The effectiveness of each approach has been proven to some extent, but no definitive treatment to eradicate cancer has been discovered. The current review discusses a broad range of nano-radiosensitizers, summarizing possible combinations of radiosensitizing NPs with several other types of cancer therapy options, focusing on the benefits and drawbacks, challenges, and future prospects.
Ray tracing and binary tree computations using PVM (2002)

The authors investigate the design, analysis, and implementation issues of algorithms for two computational problems-namely, ray tracing and bottom-up binary tree computation-in a distributed setting. The implementations have been performed on a cluster of workstations running on parallel virtual machine (PVM). Ray tracing algorithms for rendering computer synthesized images are computationally expensive due to the very long computing time required to calculate the intersection of each ray with all objects. The authors propose a variant of a recent static load balancing technique proposed by T. Priol and K. Boatouch (1989), where the sampling is based on partitioning the object space. This usually results in poor processor efficiency. The approach to this is to partition the image instead and use an efficient scheduling technique to allocate work to individual processors. The advantage of the distributed algorithm is that it can be used with any sequential algorithm for ray tracing. The other problem addressed is distributed binary tree computations. The tree contraction problem in a distributed setting is studied.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Zeolitic Intermetallics: LnNiSi (Ln = La–Nd) (2019)

LnNiSi (Ln = La-Nd) comprising a three-dimensional NiSi framework has electrons in the crystallographic cavity space. In the temperature region 473-773 K, it accepts the insertion/de-insertion of hydrogen topotactically without a change in unitcell volume. The insertion of hydrogens into the cavity space is accompanied by a redox reaction with the orbitals of atoms constituting the cavity wall. Having small work functions, such intermetallic electrides exhibit metallic electrical and magnetic properties. Owing to a high electron-donating power and reversible exchange between hydrogen and the electrons, Ru5wt%-loaded LaNiSi powder worked as an efficient catalyst for ammonia synthesis under ambient pressure.
Physical Modeling of Line-of-Sight Wideband Propagation in a City Street for Microcellular Communication (2000)

This paper proposes a three-dimensional (3D) spatial variant wideband multi-ray model for line-of-sight radio wave propagation in a city street. An analytical expression of the spatial variant channel transfer function is derived. The model provides 3D propagation information for both the base and mobile stations, e.g., direction of arrival, which makes it useful in antenna array applications. The developed model can be used to predict both wideband, e.g., angle and delay spread, and narrowband, e.g., path loss, propagation characteristics in a city street with any number of crossing streets of different widths. The proposed 3D wideband model is compared with an experimentally verified two-ray wideband model described in [18]. The model is easy to implement and fast to compute since there is no searching for coupling rays.
The Fire Ant (Hymenoptera: Formicidae) Pathogen,Vairimorpha invictae(Microsporidia: Burenellidae), Not Detected in Florida (2012)

Vairimorpha invictae Jouvenaz & Ellis (Micro sporidia: Burenellidae) is a microsporidian patho gen of Solenopsis fire ants in South America. Be cause Solenopsis invicta Buren fire ants infected with V. invictae were associated with higher mor tality, significantly slower colony growth, and re ductions in field populations in Argentina, there is considerable interest in utilizing this pathogen as a classical biological control agent against S. invicta in the U.S. (Briano & Williams 2002; Oi et al. 2005; Briano 2005). V. invictae was formally described by Jouvenaz & Ellis in 1986, however, it was most likely observed much earlier, being the undescribed, dimorphic microsporidium re ported from pathogen surveys conducted in Brazil in 1976 and 1979 (Jouvenaz et al., 1980; Briano & Williams 2002). Surveys for V. invictae in Ar gentina reported prevalence rates of 1, 2.3, and 10% after sampling 1836, 2528, and 2064 nests, respectively (Briano et al. 1995; 2006; Briano & Williams 2002). In the U.S., there have been surveys for vari ous fire ant pathogens since the 1970s. Limited surveys of red and black imported fire ants, S. in victa and Solenopsis richteri Forel, respectively, were conducted in northern Florida and in Mis
Demonstration of an enhanced trench Bimode Insulated Gate Transistor ET-BIGT (2016)

In this paper, a 3300V Bimode Insulated Gate Transistor BIGT chip utilizing an Enhanced Trench MOS cell is demonstrated. The paper provides an insight into the ET-BIGT device design along with the static and dynamic electrical results obtained from the first manufactured prototypes. The combined advantages of a low loss Enhanced Trench cell concept and BIGT chip integration sets a new milestone for delivering higher output power for the next generation BIGT power modules.
Initialize and Weak-Program Erasing Scheme for High-Performance and High-Reliability Ferroelectric NAND Flash Solid-State Drive (2012)

Initialize and weak-program erasing scheme is proposed to achieve high-performance and high-reliability Ferroelectric (Fe-) NAND flash solid-state drive (SSD). Bit-by-bit erase VTH control is achieved by the proposed erasing scheme and history effects in Fe-NAND is also suppressed. History effects change the future erase VTH shift characteristics by the past program voltage. The proposed erasing scheme decreases VTH shift variation due to history effects from ±40% to ±2% and the erase VTH distribution width is reduced from over 0.4V to 0.045V. As a result, the read and VPASS disturbance decrease by 42% and 37%, respectively. The proposed erasing scheme is immune to VTH variations and voltage stress. The proposed erasing scheme also suppresses the power and bandwidth degradation of SSD.
Memory-mapping support for reducer hyperobjects (2012)

Reducer hyperobjects (reducers) provide a linguistic abstraction for dynamic multithreading that allows different branches of a parallel program to maintain coordinated local views of the same nonlocal variable. In this paper, we investigate how thread-local memory mapping (TLMM) can be used to improve the performance of reducers. Existing concurrency platforms that support reducer hyperobjects, such as Intel Cilk Plus and Cilk++, take a hypermap approach in which a hash table is used to map reducer objects to their local views. The overhead of the hash table is costly --- roughly 12x overhead compared to a normal L1-cache memory access on an AMD Opteron 8354. We replaced the Intel Cilk Plus runtime system with our own Cilk-M runtime system which uses TLMM to implement a reducer mechanism that supports a reducer lookup using only two memory accesses and a predictable branch, which is roughly a 3x overhead compared to an ordinary L1-cache memory access. An empirical evaluation shows that the Cilk-M memory-mapping approach is close to 4x faster than the Cilk Plus hypermap approach. Furthermore, the memory-mapping approach admits better locality than the hypermap approach during parallel execution, which allows an application using reducers to scale better.
Lightweight Multi-View 3D Pose Estimation Through Camera-Disentangled Representation (2020)

We present a lightweight solution to recover 3D pose from multi-view images captured with spatially calibrated cameras. Building upon recent advances in interpretable representation learning, we exploit 3D geometry to fuse input images into a unified latent representation of pose, which is disentangled from camera view-points. This allows us to reason effectively about 3D pose across different views without using compute-intensive volumetric grids. Our architecture then conditions the learned representation on camera projection operators to produce accurate per-view 2d detections, that can be simply lifted to 3D via a differentiable Direct Linear Transform (DLT) layer. In order to do it efficiently, we propose a novel implementation of DLT that is orders of magnitude faster on GPU architectures than standard SVD-based triangulation methods. We evaluate our approach on two large-scale human pose datasets (H36M and Total Capture): our method outperforms or performs comparably to the state-of-the-art volumetric methods, while, unlike them, yielding real-time performance.
Quantifying the impact of rare and ultra-rare coding variation across the phenotypic spectrum (2017)

Abstract There is a limited understanding about the impact of rare protein truncating variants across multiple phenotypes. We explore the impact of this class of variants on 13 quantitative traits and 10 diseases using whole-exome sequencing data from 100,296 individuals. Protein truncating variants in genes intolerant to this class of mutations increased risk of autism, schizophrenia, bipolar disorder, intellectual disability, ADHD. In individuals without these disorders, there was an association with shorter height, lower education, increased hospitalization and reduced age. Gene sets implicated from GWAS did not show a significant protein truncating variants-burden beyond what captured by established Mendelian genes. In conclusion, we provide the most thorough investigation to date of the impact of rare deleterious coding variants on complex traits, suggesting widespread pleiotropic risk. Main abbreviations PTV = Protein Truncating Variants PI = Protein Truncating Intolerant PI-PTV = Protein Truncating Variant in genes that are Intolerant to Protein Truncating Variants
Deep Learning Assisted Doppler Sensing for Hydrocarbon Downhole Flow Velocity Estimation (2021)

Abstract Logging hydrocarbon production potential of wells has been at the forefront of enhancing oil and gas exploration and maximize productivity from oil and gas reservoirs. A major challenge is accurate downhole fluid phases flow velocity measurements in production logging due to the criticality of mechanical spinner-based sensor devices. Ultrasonic Doppler based sensors are more robust and deployable either in wireline or logging while drilling (LWD) conditions; however, due to the different sensing physics, the measurement results may not be equivalent. We present in this work an innovative deep learning framework to estimate spinner phase velocities from Doppler based sensor velocities. Tests of the framework on a benchmark dataset displayed strong estimation results. This allows for the real-time automatic interpretative framework implementation and flow velocity estimations either in conventional wireline production logging technologies (PLTs) and potentially also in LWD conditions, when the well is flowing in underbalanced conditions.
RACEMIZATION EFFECTS ON MELANOCYTE-STIMULATING HORMONES AND RELATED PEPTIDES (1981)

Heat–alkali treatment of synthetic α- and β-melanocyte-stimulating hormones (MSH), known to cause racemization of amino acids within the peptides, results in prolongation of the darkening (melanophore dispersion) effect of these hormones on frog and lizard skins in vitro . Skins remain darkened for hours or even days if supramaximal concentrations of the racemized hormones are used. This response can be partially reversed by melatonin or noradrenaline. Heat–alkali treatment of α-MSH at either 60 or 97 °C results in a retardation of the response of the skins to the racemized peptides. In contrast, the response of frog skins to heat–alkali-treated β-MSH is immediately enhanced and potentiated. Heat–alkali treatment also prolongs and potentiates the activity of synthetic [des-acetyl]-α-MSH (in contrast to the retardation effect on the natural acetylated peptide). These data suggest a role for the N -acetyl group in the retardation phenomenon. The activity of synthetic [2- d -tyrosine]-α-MSH is much lower than that of α-MSH itself, indicating that heat–alkali treatment of the hormone may produce either potentiation or partial inactivation of the peptide, depending on the site of racemization.