gebhart/patrepeval huggingface dataset:
The Curious Home (2007)

From 29 June to 15 July 2007, the Interaction Research Studio from Goldsmiths, University of London presents The Curious Home, an exhibition of electronic furniture that demonstrates a radical vision of home technology. Working with London households, the team has designed pieces that electronically highlight aspects of the local environment, transforming information to encourage exploration, interpretation and wonder. The designs themselves are shown alongside documentary films that capture how Londoners lived with the furniture in their homes.

On show will be several pieces, including:
> The Plane Tracker – an appliance that tracks passing flight traffic and imagines views of their journeys.
> The Local Barometer – small devices that display text and images from local classifieds as if blown through the home.
> The Drift Table – a table that drifts over the landscape giving aerial views of Britain.

This work avoids the well-worn paths of using digital technologies to support work, consumption and leisure. In the studio’s view, new technologies should encourage people to become active participants in their digital lifestyles, helping them explore the world around them rather than seeking to escape it.

As well as seeing how people have lived with these unique pieces, there is an opportunity for visitors to get involved as the studio is looking for additional adopters of future work.

The Curious Home brings together the work of the Interaction Research Studioi¦s six-year project investigating the future of domestic technology and how we live with it. This work has received international exposure in the past, and the Curious Home Exhibition is a chance to see previously exhibited work alongside new pieces.

An illustrated catalogue, including essays by noted commentators on design, technology and society, will be published to accompany the exhibition.

Equator is a six-year Interdisciplinary Research Collaboration funded by the Engineering and Physical Sciences Research Council (EPSRC) that brings together researchers based in seven UK universities.

Equator’s central goal is to investigate the integration of the physical and digital worlds by developing innovative systems. The Interaction Research Studio at Goldsmiths, University of London led the project’s focus on new technology for the home.

The Interaction Research Studio members are: Andy Boucher, John Bowers, Bill Gaver, Nadine Jarvis, Tobie Kerridge, Andy Law and Sarah Pennington.

EXHIBITION DATES: 29 June – 15 July 2007
PREVIEW EVENING: 5pm 28 June 2007
VENUE: Pacific Playhouse, 5-6 Playhouse Court, 62 Southwark Bridge Road, Bankside LONDON SE1 0AT
GALLERY OPENING HOURS: Daily from 12 – 6; Fri until 8 pm
Evaluation of the phadebact and bactigen reagents for detection of Neisseria meningitidis in cerebrospinal fluid (1985)

The Phadebact and Bactigen reagents were evaluated for detection of Neisseria meningitidis in cerebrospinal fluids. The Bactigen test yielded stronger agglutination reactions from clinical specimens and was significantly more sensitive when used with whole-cell suspensions and purified antigens.
Cascade Kinetics of an Artificial Metabolon by Molecular Dynamics and Kinetic Monte Carlo (2018)

Natural enzyme cascades are able to employ electrostatic channeling as an efficient mechanism for shuttling charged intermediates between sequential active sites. Application of channeling mechanisms to artificial cascades has drawn increasing attention for its potential to improve cascade design. We report a quantitative model of a two-step artificial metabolon that accounts for molecular-level complexity. Conversion of glucose to phospho-6-gluconolactone by hexokinase and glucose-6-phosphate dehydrogenase, covalently conjugated by a cationic oligopeptide bridge, is simulated and validated by comparison to stopped-flow lag time analysis. Specifically, molecular dynamics (MD) simulations enable the calculation of energy-determined surface equilibrium constants and surface diffusivity, and a kinetic Monte Carlo (KMC) model integrated all rate constants from MD (e.g., surface diffusion and desorption rate) and experiments (e.g., turnover frequency), to estimate the product evolution on an experimental time scale, starting from presteady state. Simulations, conducted as a function of ionic strength, compare well to experiment and indicate that bridge-enzyme leakage is a major limitation accounting for significant lag time increase. Reducing the energy barrier between the channeling pathway and binding pocket could further improve channeling efficiency. Bridge length is also found to have a significant effect on overall kinetics.
Phosphorus-containing inhibitors of endothelin converting enzyme: effects of the electronic nature of phosphorus on inhibitor potency (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhosphorus-containing inhibitors of endothelin converting enzyme: effects of the electronic nature of phosphorus on inhibitor potencyStephen R. Bertenshaw, Roland S. Rogers, Michael K. Stern, Bryan H. Norman, William M. Moore, Gina M. Jerome, Linda M. Branson, John F. McDonald, Ellen G. McMahon, and Maria A. PalomoCite this: J. Med. Chem. 1993, 36, 1, 173–176Publication Date (Print):January 1, 1993Publication History Published online1 May 2002Published inissue 1 January 1993https://pubs.acs.org/doi/10.1021/jm00053a023https://doi.org/10.1021/jm00053a023research-articleACS PublicationsRequest reuse permissionsArticle Views316Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Common Genetic Variation and the Control of HIV-1 in Humans (2009)

To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC). We also examined the polymorphisms reported in previous candidate gene studies and fail to support a role for any variant outside of the MHC or the chemokine receptor cluster on chromosome 3. In addition, we evaluated functional variants, copy-number polymorphisms, epistatic interactions, and biological pathways. This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians.
<i>In vitro</i> evaluation of Her2 expression and ADC cytotoxicity. (2015)

&lt;p&gt;The expression of Her2 and the &lt;i&gt;in vitro&lt;/i&gt; cytotoxicity of the ADCs are evaluated in the HCC-1954, NCI-N87, MDA-MB-453 and MDA-MB-468 cell lines. (A) The cell surface expression of Her2 is measured via FACS for a panel of tumor cell lines. HCC-1954, MDA-MB-453 and NCI-N87 were selected as the Her2 expressing cell lines while MDA-MB-468 was selected as the Her2 negative cell line. MDA-MB-453 cells are resistant to Herceptin. (B) NCI-N87 and HCC-1954 tumor xenografts were evaluated for Her2 expression via IHC. (C) The &lt;i&gt;in vitro&lt;/i&gt; cytotoxicity of the anti-Her2 ADCs were evaluated in the HCC-1954, NCI-N87, MDA-MB-453 and MDA-MB-468 cell lines.&lt;/p&gt;
Oxygen-Air Blending Nomogram (1977)

YOST, LEON C. RCVT; BERNHARD, WILLIAM N. MD; MERRILL, CHARLES BS; TURNDORF, HERMAN MD Author Information
Heterogeneous Composition and Microstructure of Elastomeric Polypropylene from a Sterically Hindered 2-Arylindenylhafnium Catalyst (2004)

The metallocene catalyst bis(2-(3,5-di-tert-butylphenyl)indenyl)hafnium dichloride yields elastomeric polypropylene in the presence of a MAO cocatalyst at 50 °C in liquid propylene. The polymer synthesized has Mw = 201 000 and narrow polydispersity (Mw/Mn = 2.3) with an average isotacticity [mmmm] = 34%. Several methods of fractionations were carried out to investigate the heterogeneity of the elastomeric polypropylene: thermal fractionation by DSC, boiling-solvent extraction, supercritical fluid fractionation employing increasing pressure profiling (IPP), and critical isobaric temperature rising elution fractionation (CITREF). Thermal fractionation reveals a distribution of crystallizable fractions with several melting points between 40 and 100 °C and a large melting endotherm at 150 °C which is attributed to the presence of long crystallizable segments. Fractionation by boiling-solvent extraction separates the elastomeric polypropylene into three fractions where the molecular weight, tacticity, and crystallinity increase in the following order: ether-soluble < heptane-soluble < heptane-insoluble fractions. Supercritical fluid fractionations by either molecular weight (IPP) or crystallinity (CITREF) show that the tacticities, melting points, and heats of fusion increase gradually with increasing molecular weight.
Selective Visual Detection of TNT at the Sub‐Zeptomole Level (2012)

Eins zu eins: Der visuelle Nachweis von 2,4,6-Trinitrotoluol und Hg2+ im Zeptomol-Bereich und darunter gelingt mithilfe eines Hybridmaterials. Die hierfür genutzte Ein-Partikel-ein-Molekül-Technik könnte die ultimative Lösung für die selektive Detektion kleinster Substanzspuren bieten.
Effect of stator shifting on harmonic cancellation and flux weakening performance of interior PM machines equipped with fractional-slot concentrated windings for hybrid traction applications (2012)

Electrical drive systems, which include electrical machines and power electronics, are a key enabling technology for advanced vehicle propulsion systems that reduce the petroleum dependence of the ground transportation sector. To have significant effect, electric drive technologies must be economical in terms of cost, weight, and size while meeting performance and reliability expectations. Interior Permanent Magnet (IPM) with fractional-slot concentrated-windings have been shown to be good candidates for hybrid traction applications. One of the key challenges is the additional stator mmf sub- and super-harmonic components that lead to higher losses in the rotor as well as saturation effects. This paper tries to address this issue by looking into the concept of stator shifting to cancel out the harmonics in fractional slot concentrated windings, while also considering the flux weakening performance under such effects. The novel aspects of the paper will be highlighted in the introduction section. The concept of stator shifting will be explained, the effect of varying the shift angle on the various harmonic components and winding factors will be investigated. Various designs, arising out of single layer and double winding layer 10-pole, 12-slot configuration along with double winding layer 16-pole, 18-slot configuration (targeting the FreedomCAR specifications), with varied shift angles are evaluated. The comparison between these designs in terms of their power density, efficiency and torque ripple is presented.
Supplementary Figure Legend from Glioblastoma Stem Cells Are Regulated by Interleukin-8 Signaling in a Tumoral Perivascular Niche (2023)

&lt;p&gt;PDF file - 26K&lt;/p&gt;
Supplementary Figure 3 from Plasminogen Kringle 5 Induces Apoptosis of Brain Microvessel Endothelial Cells: Sensitization by Radiation and Requirement for GRP78 and LRP1 (2023)

Supplementary Figure 3 from Plasminogen Kringle 5 Induces Apoptosis of Brain Microvessel Endothelial Cells: Sensitization by Radiation and Requirement for GRP78 and LRP1
3D dose delivery QA using couch and gantry mounted cameras (2022)

Abstract While 2D planar radiation therapy quality assurance techniques suffice for linac verification, a full 3D dosimetry measurement is ideal for robust treatment plan verification. In this study, an optical 3D dose reconstruction technique based on radioluminescence imaging is presented, using two orthogonal views provided by gantry and couch mounted cameras. Both small field and multi-target beam apertures were tested, mimicking typical 3D radiosurgery plans. Pass rates &gt;94% for 3D gamma with 2%/2mm were achieved in all cases. Slice images were used for gamma analysis in each of transverse, sagittal and coronal planes, through the point of maximum dose. This proposed system can enable real-time imaging of beam delivery dynamics in a cylindrical water-equivalent phantom with high spatial resolution 3D reconstruction of the dose distribution, and verification of each beamlet used.
Surface Effects on the Physical and Electrochemical Properties of Thin LiFePO4 Particles (2007)

The structure of LiFePO4 particles prepared by a new milling route has been investigated, with emphasis on surface effects found to be important for such small particles, whose sizes were distributed in the range 30–40 nm. The bulk and surface properties of the particles were investigated by a combination of XRD, TEM, FTIR, and magnetic measurements before and after application of a carbon coating intended to optimize the electrochemical performance of the powder used as a cathode element of a new generation of lithium-ion battery. Before the carbon coating was applied, the particles were well-crystallized in the bulk and free from any impurities, but they were surrounded with a disordered, ~8 Å thick surface layer in which the iron ions were in the Fe3+ low-spin (S = 1/2) configuration. Carbon coating at 750 °C reduced the disorder at the surface and switched the Fe3+ ions in the surface layer to the high-spin (S = 5/2) configuration. These results are discussed with respect to similar effects recently observed for ferrite nanoparticles used in spintronics and biological molecules such as proteins that contain heme Fe.
Hybrid native phosphorescence and fluorescence spectroscopy for cancer detection (2006)

Native fluorescence of tissues in the UV and visible spectral regions has been investigated for over two decades. Native fluorescence has been demonstrated to be an accurate tools for distinguish normal tissue from malignant and pre-malignant. Prior investigations have demonstrated that there are several ratio-based algorithms, which can distinguish malignant tissue from normal with high sensitivity and specificity.<sup>1</sup> The wavelength combinations used in these ratios isolate the contributions from pairs of tissue fluorophors, one of which is frequently tryptophan (trp), the predominant tissue fluorophore with excitation in the UV (250-300 nm). In this work, algorithms using a combination of native fluorescence and trp phosphorescence were developed which show promise for providing enhanced detection accuracy. Using optical fibers to collect the emission from the specimen allowed interrogation of small regions of tissue, providing precise spatial information. Using a specially designed setup, specimens were excited in the UV and spectra were collected in the range of 300 to 700 nm. Three main emission bands were selected for analysis: 340 nm (trp fluorescence); 420 - 460 nm band (fluorescence from the extra cellular matrix); and 500 - 520 nm (trp phosphorescence). Normal specimens consistently exhibited a low ratio (<10) of 345 to 500 nm emission intensity while this same ratio was consistently high (>15) for cancer specimens. Creating intensities ratio maps from the tissue allows one to localize the malignant regions with high spatial precision. The study was performed on ex vivo human breast tissues. The ratio analysis correlated well with histopathology.
Networks based on QKD and weakly trusted repeaters (2013)

We study how to use quantum key distribution (QKD) in common optical network infrastructures and propose a method to overcome its distance limitations. QKD is the first technology offering information theoretic secret-key distribution that relies only on the fundamental principles of quantum physics. Point-to-point QKD devices have reached a mature industrial state; however, these devices are severely limited in distance, since signals at the quantum level (e.g. single photons) are highly affected by the losses in the communication channel and intermediate devices. To overcome this limitation, intermediate nodes (i.e. repeaters) are used. Both, quantum-regime and trusted, classical, repeaters have been proposed in the QKD literature, but only the latter can be implemented in practice. As a novelty, we propose here a new QKD network model based on the use of not fully trusted intermediate nodes, referred as weakly trusted repeaters. This approach forces the attacker to simultaneously break several paths to get access to the exchanged key, thus improving significantly the security of the network. We formalize the model using network codes and provide real scenarios that allow users to exchange secure keys over metropolitan optical networks using only passive components.
Advances in Understanding of the Immune Response to Mycobacterial Pathogens and Vaccines through Use of Cattle and Mycobacterium avium subsp. paratuberculosis as a Prototypic Mycobacterial Pathogen (2021)

Lack of understanding of the immune response to mycobacterial pathogens has impeded progress in development of vaccines. Infection leads to development of an immune response that controls infection but is unable to eliminate the pathogen, resulting in a persistent infection. Although this puzzle remains to be solved, progress has been made using cattle as a model species to study the immune response to a prototypic mycobacterium, <i>Mycobacterium a. paratuberculosis</i> (<i>Map</i>). As chronicled in the review, incremental advances in characterizing the immune response to mycobacteria during the last 30 years with increases in information on the evolution of mycobacteria and <i>relA</i>, a gene regulating the stringent response, have brought us closer to an answer. We provide a brief overview of how mycobacterial pathogens were introduced into cattle during the transition of humankind to nomadic pastoralists who domesticated animals for food and farming. We summarize what is known about speciation of mycobacteria since the discovery of <i>Mybacterium tuberculsis</i>&nbsp;<i>Mtb</i>, <i>M. bovis</i>&nbsp;<i>Mbv</i>, and <i>Map</i> as zoonotic pathogens and discuss the challenges inherent in the development of vaccines to mycobacteria. We then describe how cattle were used to characterize the immune response to a prototypic mycobacterial pathogen and development of novel candidate vaccines.
Design of hydropathically complementary peptides for Big Endothelin affinity purification (1992)

Molecular recognition between Big Endothelin (Big ET) and a computer generated peptide hydropathically complementary to Big ET[16-29] sequence has been studied by analytical high performance liquid affinity chromatography (HPLAC), circular dichroism (CD) and nuclear magnetic resonance (NMR) experiments. Specific binding was observed between solid support immobilized complementary peptide and Big ET[1-38], [1-32], and [16-32], but not with Big ET fragments [1-21], [16-21], [22-32], and [22-38], obtained by chymotrypsin proteolytic degradation. Selectivity in the recognition process was clearly demonstrated by the ability of complementary peptide affinity column to purify the Big ET molecule from complex peptide mixtures, even when present in very low concentrations. Similar selectivity was evidenced with the Big ET fragment [16-32], [NH2-HLDIIWVNTPEHIVPYG-COOH] containing the entire hydropathically complementary sequence. Binding was followed by marked spectroscopic changes, as monitored by circular dichroism and one- and two-dimensional nuclear magnetic resonance experiments. The NMR spectra of the complementary peptides 1:1 mixture showed variations in the chemical shifts of proton resonances in several residues, both in the main chain (amide protons) and in the side chains (aliphatic and aromatic protons). These data support the hypothesis of a multilocalized type of interaction between complementary peptides, where many residues along the peptide chains participate in co-operative stabilizing contacts in the forming complex.
Supplemental Table Legends from A Blueprint to Advance Colorectal Cancer Immunotherapies (2023)

&lt;p&gt;Supplemental Tables 1 and 2&lt;/p&gt;
The role of polyvinylpyrrolidone in forming open‐porous, macrovoid‐free mixed matrix sorbents from Torlon ® , a polyamide‐imide polymer (2018)

This work describes the development of an optimized spin dope for the production of open‐porous, mechanically stable fiber sorbents. The fiber sorbents in this work consist of Torlon ® polymer matrix with dispersed zeolite particles to act as the sorbent sites. Initial spinning attempts with dopes consisting of Torlon ® , 13X, n ‐methylpyrrolidone (NMP) and water yielded fibers that were prone to breaks during production and had a large number of macrovoids. To remedy this, polyvinylpyrrolidone (PVP) was introduced in the dope as a pore former and macrovoid suppressant. A separate phase diagram was developed to accommodate PVP and a new preferred spin dope composition was identified. Fibers were spun based on this concentration with adequate spinning behavior. Microscopy analysis showed that PVP was successful in reducing the prevalence of macrovoids in the fiber cross section. High sorbent wall permeance was also retained with the PVP. Further analysis of permeance measurements revealed that Knudsen flow was dominant over Poiseuille flow. The estimated pore sizes implying that the transport process lies in the transition region between molecular and Knudsen diffusion. POLYM. ENG. SCI., 58:2106–2114, 2018. © 2018 Society of Plastics Engineers
Self-sealing complex oxide resonators (2021)

Data used to produce figures 1-5 in the manuscript "Self-sealing complex oxide resonators" in the arxiv pre-print server https://arxiv.org/abs/2109.03978.
Slicing Based Resource Allocation for Multiplexing of eMBB and URLLC Services in 5G Wireless Networks (2019)

The next generation of wireless networks is intended to accommodate two major services: enhanced mobile broadband (eMBB), and ultra-reliable and low-latency communications (URLLC). The eMBB applications require higher data rates while URLLC applications require a stringent latency and high transmission success probability (i.e., reliability). The multiplexing of eMBB and URLLC services on the same network infrastructure leads to a challenging resource optimization problem. In this paper, we formulate the network slicing problem in the context of time-frequency resource blocks (RBs) allocation to the wireless system consisting of eMBB and URLLC users. In particular, we address the sum-rate maximization problem subject to latency and slice isolation constraints while assuring certain reliability requirements with the use of adaptive modulation coding (AMC). We relax the mathematical intractability of AMC and binary assignment variable and show the effectiveness of the proposed approach through numerical simulations.