gebhart/patrepeval huggingface dataset:
Magnetic coupling in Gd/Ni bilayers (2008)

Layered thin films consisting of rare earth materials and magnetic transition metals reveal a variety of magnetic properties due to their complex coupling interactions. The Gd/Ni system adds its own features due to the interplay of saturation moments and Curie temperatures of these two metals. Magnetic coupling in Gd/Ni bilayers leads to negative remanence and interesting magnetic switching behavior, which is strongly temperature-dependent. A transition from the 'nickel-aligned' state to the 'gadolinium-aligned' state is observed at 45 K, independent of the chosen substrate and hence of the Curie point of the Gd layer, which depends on the substrate. In x-ray magnetic circular dichroism experiments a polarization of Gd moments at the interface antiparallel to the Ni layer was observed even at room temperature. Structural analysis show a rough Gd/Ni interface with grains of a few nm and an amorphous Gd growth is indicated by diffraction methods.
The effect of medical and surgical treatment on subsequent sudden cardiac death in patients with coronary artery disease: a report from the Coronary Artery Surgery Study. (1986)

The effect of medical and surgical treatment on subsequent sudden cardiac death was assessed in 13,476 patients in the Coronary Artery Surgery Study registry who had significant coronary artery disease, operable vessels, and no significant valvular disease. (Patients were assigned to medical or surgical therapy on the basis of clinical judgment and not according to a randomization scheme; therefore, biases associated with unknown variables could not be evaluated.) Sudden cardiac death occurred in 452 patients (3.4%) during a mean follow-up of 4.6 years. Five year survival free of sudden death for medically treated patients was 94 +/- 0.3%, and that for surgically treated patients was 98 +/- 0.2% (p less than .0001). Twelve baseline clinical, electrocardiographic, and angiographic variables were significantly different between patients alive at the last follow-up and those suffering sudden death. Data on these variables were available for 11,508 patients. Sudden death occurred in 257 (4.9%) of 5258 medically treated and 101 (1.6%) of 6250 surgically treated patients. In a high-risk patient subset with three-vessel disease and history of congestive heart failure, 91% of surgically treated patients had not suffered sudden death compared with 69% of medically treated patients. After Cox survival analysis was used to correct for baseline variables, surgical treatment had an independent effect on sudden death (p less than .0001). This reduction was most pronounced in high-risk patients.
General Synthesis of β-Alanine-Containing Spider Polyamine Toxins and Discovery of Nephila Polyamine Toxins 1 and 8 as Highly Potent Inhibitors of Ionotropic Glutamate Receptors (2012)

Certain spiders contain large pools of polyamine toxins, which are putative pharmacological tools awaiting further discovery. Here we present a general synthesis strategy for this class of toxins and prepare five structurally varied polyamine toxins. Electrophysiological testing at three ionotropic glutamate receptor subtypes reveals that two of these, Nephila polyamine toxins 1 (NPTX-1) and 8 (NPTX-8), comprise intriguing pharmacological activities by having subnanomolar IC(50) values at kainate receptors.
A Highly Selective Ethylene Tetramerization Catalyst (2012)

Small change, big difference: The introduction of an additional CH2 group into the bridge of ligands with two P/N units leads to a different selectivity of the corresponding chromium-based catalysts. Whereas 1 produces an ethylene trimerization system, 2 provides an unprecedented ethylene tetramerization system that produces 1-octene with high purity and little or no polymer side products (see scheme; DMAO=Me3Al-depleted methylaluminoxane). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
The Synthesis of Functionalized Nanoscale Molecular Rods of Defined Length (2003)

We report a synthetic approach to spiro-ladder oligomers of defined length and structure that form water-soluble molecular rods. We describe the synthesis of a chiral molecular building block 1 and its assembly on solid support to form flexible chains that were then rigidified by the parallel formation of several diketopiperazine rings. Two molecular rods approximately 15 and 25 A in length were synthesized containing three and five monomers, respectively. The molecular rods were easily functionalized on both ends and were shown to have high water solubility, making them compatible with biological buffers. These molecules may find use as scaffolds for the display of ligands in chemical-biology applications and as spacers and construction materials for nanoscience applications.
Anticipation on age at onset in kindreds with hereditary ATTRV30M amyloidosis from the Majorcan cluster (2020)

AC was no uncommon in our cohort, and AO tended to decrease in successive generations.
Recent R&D Activities at Hawker de Havilland (1989)

In-house research and development programs are primarily aimed at aircraft/engine production or maintenance improvements. This paper deals with the recent R & D activities. Recently the system has been upgraded. Many factors are needed to be included in the integration of aster bombs on aircrafts. The Advanced Staggered Triple Ejector Rack (ASTER) design was used for the purpose. Thus the aster project has shown capability of Australian industry to develop new aircrafts.
Evolution of Multivalent Nanoparticle Adhesion via Specific Molecular Interactions (2016)

The targeted delivery of nanoparticle carriers holds tremendous potential to transform the detection and treatment of diseases. A major attribute of nanoparticles is the ability to form multiple bonds with target cells, which greatly improves the adhesion strength. However, the multivalent binding of nanoparticles is still poorly understood, particularly from a dynamic perspective. In previous experimental work, we studied the kinetics of nanoparticle adhesion and found that the rate of detachment decreased over time. Here, we have applied the adhesive dynamics simulation framework to investigate binding dynamics between an antibody-conjugated, 200-nm-diameter sphere and an ICAM-1-coated surface on the scale of individual bonds. We found that nano adhesive dynamics (NAD) simulations could replicate the time-varying nanoparticle detachment behavior that we observed in experiments. As expected, this behavior correlated with a steady increase in mean bond number with time, but this was attributed to bond accumulation only during the first second that nanoparticles were bound. Longer-term increases in bond number instead were manifested from nanoparticle detachment serving as a selection mechanism to eliminate nanoparticles that had randomly been confined to lower bond valencies. Thus, time-dependent nanoparticle detachment reflects an evolution of the remaining nanoparticle population toward higher overall bond valency. We also found that NAD simulations precisely matched experiments whenever mechanical force loads on bonds were high enough to directly induce rupture. These mechanical forces were in excess of 300 pN and primarily arose from the Brownian motion of the nanoparticle, but we also identified a valency-dependent contribution from bonds pulling on each other. In summary, we have achieved excellent kinetic consistency between NAD simulations and experiments, which has revealed new insights into the dynamics and biophysics of multivalent nanoparticle adhesion. In future work, we will leverage the simulation as a design tool for optimizing targeted nanoparticle agents.
Structure and mechanical flexibility of carbon nanotube ribbons: An atomic-force microscopy study (2001)

Collapsed multiwalled carbon nanotube (MWCNT) sections and segments (carbon nanotube ribbons) on surfaces were observed by atomic-force microscopy. The collapsed form of these MWCNTs allowed the determination of the layer number and the inner and outer diameters for their uncollapsed form. The results show that such carbon nanotube ribbons are extremely flexible and readily conform to the underlying substrate morphology. The formation of the collapsed form of these nanotubes is consistent with recent theoretical analysis on the mechanics of nanotubes.
High reliability operation of 2 kW QCW 10-bar laser diode stacks at 808 nm (2009)

This paper presents the results obtained by Intense during the development of its 2 kW stack using Quantum Well Intermixing (QWI). A 200 W QCW bar operating at 808 nm has been designed with a 1 mm long cavity of which only a fraction is actively pumped. The bar has an 80% fill factor, and ten 200 W bars were stacked vertically in a G-type package with a 417 &mu;m bar-to-bar pitch. The resulting compact emission area makes the stack compatible with most existing laser and electro-optic systems. A lifetime of 1x10<sup>9</sup> shots has been obtained with no measurable degradation.
InP-based waveguide photodiodes heterogeneously integrated on silicon-on-insulator for photonic microwave generation (2013)

High-linearity modified uni-traveling carrier photodiodes on silicon-on-insulator with low AM-to-PM conversion factor are demonstrated. The devices deliver more than 2.5 dBm RF output power up to 40 GHz and have an output third order intercept point of 30 dBm at 20 GHz. Photodiode arrays exceed a saturation current-bandwidth-product of 630 mA · GHz and reach unsaturated RF output power levels of 10 dBm at 20 GHz.
Nonparametric Inverse Dynamic Models for Multimodal Interactive Robots (2019)

Direct design of a robot's rendered dynamics, such as in impedance control, is now a well-established control mode in uncertain environments. When the physical interaction port variables are not measured directly, dynamic and kinematic models are required to relate the measured variables to the interaction port variables. A typical example is serial manipulators with joint torque sensors, where the interaction occurs at the end-effector. As interactive robots perform increasingly complex tasks, they will be intermittently coupled with additional dynamic elements such as tools, grippers, or workpieces, some of which should be compensated and brought to the robot side of the interaction port, making the inverse dynamics multimodal. Furthermore, there may also be unavoidable and unmeasured external input when the desired system cannot be totally isolated. Towards semi-autonomous robots, capable of handling such applications, a multimodal Gaussian process regression approach to manipulator dynamic modelling is developed. A sampling-based approach clusters different dynamic modes from unlabelled data, also allowing the seperation of perturbed data with significant, irregular external input. The passivity of the overall approach is shown analytically, and experiments examine the performance and safety of this approach on a test actuator.
Acylcarnitines as Translational Biomarkers of Mitochondrial Dysfunction (2018)

This chapter focuses on acylcarnitines as potential translational biomarkers of mitochondrial dysfunction. Metabolomics analysis of acylcarnitines has been conducted on blood samples of patients with acetaminophen (APAP) toxicity. Analysis can be performed as open profiling using nuclear magnetic resonance (NMR) spectroscopy or mass spectrometry (MS) methods to discover metabolites or patterns associated with an endpoint. Several recent studies show the utility of long-chain acylcarnitines as preclinical biomarkers in drug or compound toxicity evaluations. Acylcarnitines and triglycerides were increased in cells treated with hepatotoxic drugs, but the increase in acylcarnitines was only significant for drugs that caused oxidative stress and phospholipidosis. To identify molecular markers of the early stages of cardiotoxicity, L. K. Schnackenberg and coworkers examined acylcarnitine profiles in plasma and cardiac tissue in B6C3F1 male mice treated with doxorubicin. Besides liver and cardiac cells, other cell types also show acylcarnitine-induced pathophysiological effects.
MATLAB software for recursive identification of systems with output quantization : Revision 1 (2007)

MATLAB software for recursive identification of systems with output quantization : Revision 1
N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl- d -aspartate receptor activity (2003)

The molecular and neuronal substrates conferring on clozapine its unique and superior efficacy in the treatment of schizophrenia remain elusive. The interaction of clozapine with many G protein-coupled receptors is well documented but less is known about its biologically active metabolite, N-desmethylclozapine. Recent clinical and preclinical evidences of the antipsychotic activity of the muscarinic agonist xanomeline prompted us to investigate the effects of N-desmethylclozapine on cloned human M1-M5 muscarinic receptors. N-desmethylclozapine preferentially bound to M1 muscarinic receptors with an IC50 of 55 nM and was a more potent partial agonist (EC50, 115 nM and 50% of acetylcholine response) at this receptor than clozapine. Furthermore, pharmacological and site-directed mutagenesis studies suggested that N-desmethylclozapine preferentially activated M1 receptors by interacting with a site that does not fully overlap with the acetylcholine orthosteric site. As hypofunction of N-methyl-d-aspartate (NMDA) receptor-driven neuronal ensembles has been implicated in psychotic disorders, the neuronal activity of N-desmethylclozapine was electrophysiologically investigated in hippocampal rat brain slices. N-desmethylclozapine was shown to dose-dependently potentiate NMDA receptor currents in CA1 pyramidal cells by 53% at 100 nM, an effect largely mediated by activation of muscarinic receptors. Altogether, our observations provide direct evidence that the brain penetrant metabolite N-desmethylclozapine is a potent, allosteric agonist at human M1 receptors and is able to potentiate hippocampal NMDA receptor currents through M1 receptor activation. These observations raise the possibility that N-desmethylclozapine contributes to clozapine's clinical activity in schizophrenics through modulation of both muscarinic and glutamatergic neurotransmission.
REDUCED COMPLEXITY SPATIO-TEMPORAL SCALABLE MOTION COMPENSATED (2003)

Motion compensated wavelet (MC-Wavelet) video coding Choi and Woods [2]. Recently, many extensions have provides high coding efficiency and robustness along with been proposed to increase the coding efficiency and the spatio-temporal-SNR-complexity scalability. Such visual quality of MCTF schemes. Among these are schemes use a multi-resolution motion compensated lifting-based MCTF schemes proposed by Pesquettemporal filtering (MCW decomposition along with the Popescu and Bottreau 131 and by Secker and Taubman spatial wavelet transform to remove video redundancy. [4], as well as Unconstrained Motion Compensated These multi-resolution transforms partition the spatio- Temporal Filtering (UMCTF) introduced by Turaga and temporal sequence-volume into regions corresponding to van der Schaar [5]. These spatio-temporal decomposition desired spatial and temporal resolutions. In this paper, we schemes partition the sequence-volume into low and high present a novel method for reducing the motion frequencies. Various regions from within this volume estimation complexity in MC Wavelet coders by selecting represent different spatio-temporal resolutions of the adaptively different spatio-temporal decomposition video. Spatio-temporal scalability is achieved by selecting structures and temporal motion vector prediction regions from the partitioned volume as desired. schemes. We present results to highlight the reduction in In this paper, we present a new method for reducing the encoder complexity. MC-wavelet encoder complexity in order to enable realtime applications. We observe, similar to Ohm [6], that there are many different ways of performing the spatiotemporal decomposition of the sequence-volume, with each of these decomposition schemes having a different computational complexity. we can among these different schemes adaptively in order maximize the RateDistortion performance given specific encoder complexity constraints. We combine this adaptive decomposition scheme selection with temporal prediction of motion vectors (MV), between various temporal levels, to further reduce the ME complexity. Recent work on temporal prediction and coding of MVs in the MC-Wavelet framework has been presented in 171.
Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition (2018)

Activating mutations in PTPN11, encoding the cytosolic protein tyrosine phosphatase SHP2, result in developmental disorders and act as oncogenic drivers in patients with hematologic cancers. The allosteric inhibitor SHP099 stabilizes the wild-type SHP2 enzyme in an autoinhibited conformation that is itself destabilized by oncogenic mutations. Here, we report the impact of the highly activated and most frequently observed mutation, E76K, on the structure of SHP2, and investigate the effect of E76K and other oncogenic mutations on allosteric inhibition by SHP099. SHP2<sup>E76K</sup> adopts an open conformation but can be restored to the closed, autoinhibited conformation, near-identical to the unoccupied wild-type enzyme, when complexed with SHP099. SHP099 inhibitory activity against oncogenic SHP2 variants in vitro and in cells scales inversely with the activating strength of the mutation, indicating that either oncoselective or vastly more potent inhibitors will be necessary to suppress oncogenic signaling by the most strongly activating SHP2 mutations in cancer.
Romanus (2022)

Due to the high performance and safety requirements of self-driving applications, the complexity of modern autonomous driving systems (ADS) has been growing, instigating the need for more sophisticated hardware which could add to the energy footprint of the ADS platform. Addressing this, edge computing is poised to encompass self-driving applications, enabling the compute-intensive autonomy-related tasks to be offloaded for processing at compute-capable edge servers. Nonetheless, the intricate hardware architecture of ADS platforms, in addition to the stringent robustness demands, set forth complications for task offloading which are unique to autonomous driving. Hence, we present ROMANUS, a methodology for robust and efficient task offloading for modular ADS platforms with multi-sensor processing pipelines. Our methodology entails two phases: (i) the introduction of efficient offloading points along the execution path of the involved deep learning models, and (ii) the implementation of a runtime solution based on Deep Reinforcement Learning to adapt the operating mode according to variations in the perceived road scene complexity, network connectivity, and server load. Experiments on the object detection use case demonstrated that our approach is 14.99% more energy-efficient than pure local execution while achieving a 77.06% reduction in risky behavior from a robust-agnostic offloading baseline.
THE CHANGING NATURAL HISTORY OF RENAL CELL CARCINOMA (2001)

Currently patients with localized and metastatic renal cell carcinoma have had improvements in outlook and the therapeutic options available have expanded.
Supplementary Figure Legends, Figures 1 - 7 from Integration of Distinct ShcA Signaling Complexes Promotes Breast Tumor Growth and Tyrosine Kinase Inhibitor Resistance (2023)

Supplementary Figure Legends, Figures 1 - 7 from Integration of Distinct ShcA Signaling Complexes Promotes Breast Tumor Growth and Tyrosine Kinase Inhibitor Resistance
Lymphocyte-driven regional immunopathology in pneumonitis caused by impaired central immune tolerance (2019)

Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), a monogenic disorder caused by <i>AIRE</i> mutations, presents with several autoimmune diseases. Among these, endocrine organ failure is widely recognized, but the prevalence, immunopathogenesis, and treatment of non-endocrine manifestations such as pneumonitis remain poorly characterized. We enrolled 50 patients with APECED in a prospective observational study and comprehensively examined their clinical and radiographic findings, performed pulmonary function tests, and analyzed immunological characteristics in blood, bronchoalveolar lavage fluid, and endobronchial and lung biopsies. Pneumonitis was found in >40% of our patients, presented early in life, was misdiagnosed despite chronic respiratory symptoms and accompanying radiographic and pulmonary function abnormalities, and caused hypoxemic respiratory failure and death. Autoantibodies against BPIFB1 and KCNRG and the homozygous c.967_979del13 <i>AIRE</i> mutation are associated with pneumonitis development. APECED pneumonitis features compartmentalized immunopathology, with accumulation of activated neutrophils in the airways and lymphocytic infiltration in intraepithelial, submucosal, peribronchiolar, and interstitial areas. Beyond APECED, we extend these observations to lung disease seen in other conditions with secondary AIRE deficiency (thymoma and RAG deficiency). Aire-deficient mice had similar compartmentalized cellular immune responses in the airways and lung tissue, which was ameliorated by deficiency of T and B lymphocytes. Accordingly, T and B lymphocyte-directed immunomodulation controlled symptoms and radiographic abnormalities and improved pulmonary function in patients with APECED pneumonitis. Collectively, our findings unveil lung autoimmunity as a common, early, and unrecognized manifestation of APECED and provide insights into the immunopathogenesis and treatment of pulmonary autoimmunity associated with impaired central immune tolerance.
Epimutational profile of hematologic malignancies as attractive target for new epigenetic therapies (2016)

In recent years, recurrent somatic mutations in epigenetic regulators have been identified in patients with hematological malignancies. Furthermore, chromosomal translocations in which the fusion protein partners are themselves epigenetic regulators or where epigenetic regulators are recruited/targeted by oncogenic fusion proteins have also been described. Evidence has accumulated showing that "epigenetic drugs" are likely to provide clinical benefits in several hematological malignancies, granting their approval for the treatment of myelodysplastic syndromes and cutaneous T-cell lymphomas. A large number of pre-clinical and clinical trials evaluating epigenetic drugs alone or in combination therapies are ongoing. The aim of this review is to provide a comprehensive summary of known epigenetic alterations and of the current use of epigenetic drugs for the treatment of hematological malignancies.
Compliant electro-thermal microactuators (1999)

This paper describes design, microfabrication and characterisation of topology optimised compliant electro-thermal microactuators. The actuators are fabricated by a fast prototyping process using laser micromachining and electroplating. Actuators are characterised with respect to displacement, force and work, by use of image analysis. Four different actuators are presented. These actuators are capable of displacements of 30 /spl mu/m and forces of 15 mN. The most recent actuator designs function in reasonable accordance with design predictions.
A Novel Organometallic Synthesis of Highly Luminescent CdTe Nanocrystals. (2001)

Abstract For Abstract see ChemInform Abstract in Full Text.