gebhart/patrepeval huggingface dataset:
Aqueous Dispersions of Poly(ethylene oxide)-b-poly(γ-methyl-ε-caprolactone) Block Copolymers (2006)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTAqueous Dispersions of Poly(ethylene oxide)-b-poly(γ-methyl-ε-caprolactone) Block CopolymersJohn A. Zupancich, Frank S. Bates, and Marc A. HillmyerView Author Information Department of Chemical Engineering and Materials Science and Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455 Cite this: Macromolecules 2006, 39, 13, 4286–4288Publication Date (Web):May 28, 2006Publication History Received22 March 2006Revised7 May 2006Published online28 May 2006Published inissue 1 June 2006https://pubs.acs.org/doi/10.1021/ma060642shttps://doi.org/10.1021/ma060642srapid-communicationACS PublicationsCopyright © 2006 American Chemical SocietyRequest reuse permissionsArticle Views1265Altmetric-Citations87LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Copolymers,Micelles,Micellization,Solution chemistry,Vesicles Get e-Alerts
The open-loop control for the start-up of a double resonance converter using a hybrid systems approach (2006)

In the power converters area there is a growing interest in applying hybrid systems techniques for modeling, analysis and control. This paper proposes the open-loop control for the start-up of a double resonance converter using an offline nonlinear constrained optimization, where the evaluation of the cost function is obtained via simulation. In this way, difficulties related to the complexity of the system are tackled due to the exhaustive behavior modeling.
Simplifying Assays by Tableting Reagents (2017)

Medical diagnostic assays provide exquisite sensitivity and precision in the diagnoses of patients. However, these technologies often require multiple steps, skilled technicians, and facilities to store heat-sensitive reagents. Here, we developed a high-throughput compression method to incorporate different assay components into color-coded tablets. With our technique, premeasured quantities of reagents can be encapsulated in compressed tablets. We show that tableting stabilizes heat-sensitive reagents and simplifies a broad range of assays, including isothermal nucleic acid amplification techniques, enzyme-based immunoassays, and microbead diagnostics. To test the clinical readiness of this tableting technology, we show the ability of tableted diagnostics for screening hepatitis B-positive patient samples. Our development simplifies complicated assays and the transportation of reagents and mitigates the need for refrigeration of reagents. This advances the use of complex assays in remote areas with limited infrastructure.
On time delay estimation based on multichannel spatiotemporal sparse linear prediction (2016)

Noise and reverberation can significantly affect the performance of time delay estimation (TDE) in room acoustic environments. The multichannel cross-correlation coefficient (MCCC) algorithm, which extends the traditional cross-correlation method from two to multiple channels, can exploit the spatial information among multiple microphones to improve the robustness of TDE with respect to environmental noise; but this algorithm is not robust to reverberation. The multichannel spatiotemporal prediction (MCSTP) algorithm uses both the spatial and temporal information provided by the array. This algorithm improves significantly the robustness of TDE with respect to reverberation; however, it is found sensitive to noise. In this paper, we develop a multichannel spatiotemporal sparse prediction (MCSTSP) algorithm for TDE. This algorithm obtains a good compromise between robustness of TDE to noise and that to reverberation through making a tradeoff between pre-whitening and non-prewhitening. This is achieved via adjusting a regularization parameter, which is solved by an augmented Lagrangian alternating direction method of multipliers (ADMM). The property of this developed algorithm is justified with numerical experiments in both noisy and reverberant environments.
Structure and Catalytic Properties of Mesoporous Ti-Pillared Montmorillonite Solid Acid Catalysts (2005)

Mesoporous Ti-pillared montmorillonite was prepared by employing a Sol-Gel method, and then was modified by SO42- and CeO2 respectively. With this material as carrier, Cu-based Ti-pillared montmorillonite mesoporous solid acid catalysts was therefore prepared. Structure of the prepared catalyst was characterized by means of BET,XRD, TPR, Py-IR, FTIR, XPS and SEM. The catalytic properties of the material for the selective reduction of NO by propylene in excess of oxygen were further studied. The results indicate that the pillaring agent can effectively insert into the layer of montmorillonite, creating a good mesoporous structure with the distribution of pores diameters centered at 3 to 7 nm,and furthermore, obviously increasing its specific surface area. In addition, it was revealed that the chelating ligand structure formed by SO42- with Ti caused an increase in the acid amount and facilitated the formation of Bronsted acid sites. Moreover, the presence of CeO2 promoter greatly prevented the aggregation of copper crystallites. Consequently, the reduction efficacy of copper was enhanced and the performance of the prepared catalysts was significantly improved.
A probe for the mutagenic activity of the carcinogen 4-aminobiphenyl: synthesis and characterization of an M13mp10 genome containing the major carcinogen-DNA adduct at a unique site (1987)

The duplex genome of Escherichia coli virus M13mp10 was modified at a unique site to contain N-(deoxyguanosin-8-yl)-4-aminobiphenyl (dG8-ABP), the major carcinogen-DNA adduct of the human bladder carcinogen 4-aminobiphenyl. A tetradeoxynucleotide containing a single dG8-ABP residue was synthesized by reacting 5'-d(TpGpCpA)-3' with N-acetoxy-N-(trifluoracetyl)-4-aminobiphenyl, followed by high-performance liquid chromatography purification of the principal reaction product 5'-d(TpG8-ABPpCpA)-3' (yield 15-30%). Characterization by fast atom bombardment mass spectrometry confirmed the structure as an intact 4-aminobiphenyl-modified tetranucleotide, while 1H nuclear magnetic resonance spectroscopy established the site of substitution and the existence of ring stacking between the carcinogen residue and DNA bases. Both 5'-d(TpG8-ABPpCpA)-3' and 5'-d(TpGpCpA)-3' were 5'-phosphorylated by use of bacteriophage T4 polynucleotide kinase and were incorporated into a four-base gap uniquely positioned in the center of the recognition site for the restriction endonuclease PstI, in an otherwise duplex genome of M13mp10. In the case of the adducted tetranucleotide, dG8-ABP was located in the minus strand at genome position 6270. Experiments in which the tetranucleotides were 5' end labeled with [32P]phosphate revealed the following: the adducted oligomer, when incubated in a 1000-fold molar excess in the presence of T4 DNA ligase and ATP, was found to be incorporated into the gapped DNA molecules with an efficiency of approximately 30%, as compared to the unadducted d(pTpGpCpA), which was incorporated with 60% ligation efficiency; radioactivity from the 5' end of each tetranucleotide was physically mapped to a restriction fragment that contained the PstI site and represented 0.2% of the genome; the presence of the lesion within the PstI recognition site inhibited the ability of PstI to cleave the genome at this site; in genomes in which ligation occurred, T4 DNA ligase was capable of covalently joining both modified and unmodified tetranucleotides to the gapped structures on both the 5' and the 3' ends with at least 90% efficiency. Evidence also is presented showing that the dG8-ABP-modified tetranucleotide was stable to the conditions of the recombinant DNA techniques used to insert it into the viral genome.(ABSTRACT TRUNCATED AT 400 WORDS)
Analyzing the Abstractiveness-Factuality Tradeoff With Nonlinear Abstractiveness Constraints. (2021)

We analyze the tradeoff between factuality and abstractiveness of summaries. We introduce abstractiveness constraints to control the degree of abstractiveness at decoding time, and we apply this technique to characterize the abstractiveness-factuality tradeoff across multiple widely-studied datasets, using extensive human evaluations. We train a neural summarization model on each dataset and visualize the rates of change in factuality as we gradually increase abstractiveness using our abstractiveness constraints. We observe that, while factuality generally drops with increased abstractiveness, different datasets lead to different rates of factuality decay. We propose new measures to quantify the tradeoff between factuality and abstractiveness, incl. muQAGS, which balances factuality with abstractiveness. We also quantify this tradeoff in previous works, aiming to establish baselines for the abstractiveness-factuality tradeoff that future publications can compare against.
DNA interactions with cytotoxic platinum-corrole conjugates (2014)

One of the great challenges in cancer treatment is the selective targeting of cancer cells over normal cells. The&#13;\nspecific nuclear penetration of functionalizable corroles introduces the possibility of targeted, efficient delivery of&#13;\ncovalently-tethered chemotherapy drugs. Indeed, previous expts. demonstrate a sulfonated corrole can act as&#13;\na carrier mol. for chemotherapeutic agents, specifically the DNA-intercalating anthracycline drug doxorubicin,&#13;\nresulting in enhanced drug cytotoxicity. Anticancer drugs due to their notorious lack of specificity for cancerous&#13;\ncells over normal cells and their need to be localized in the nucleus to be effective. Exploiting the selective&#13;\nuptake of the sulfonated corrole into the nucleus of brain metastatic prostate carcinoma by synthesizing a&#13;\nplatinum-corrole conjugate could result in a highly specific and effective treatment for this type of&#13;\nmetastases. Synthethic routes to bioactive platinum-corrole conjugates and their interactions with DNA&#13;\nwill be presented.
A translocation t(6;7)(p11–p12;q22) associated with autism and mental retardation: localization and identification of candidate genes at the breakpoints (2008)

It is conceivable that one or more of the copy number variant regions or either of the two breakpoint locations and the dystonin gene, in particular, may be a new locus for a form of mental retardation, which may also include autistic features.
New Triene-ansamycins, Thiazinotrienomycins F and G and a Diene-ansamycin, Benzoxazomycin. (2000)

New triene-ansamycins designated thiazinotrienomycins F (TT-F) and G (TT-G) and a new diene-ansamycin, benzoxazomycin, were isolated from a culture broth of Streptomyces sp. MJ672-m3 and their structures were elucidated by spectroscopic analyses. The Mean Graphs of TT-G suggests that the tumor growth inhibitory activities are almost as strong as TT-B, in respect of GI50 and TGI against several human cancer cell lines.
Hybrid graphene-silicon photonics devices (2015)

We will review state-of-the-art of hybrid graphene silicon photonics devices, discussing electro-absorption modulators, detectors and controllable saturable absorption.
Hollow Platinum Nanoshell Tube Arrays: Fabrication and Characterization (2009)

Thin hollow platinum tubes are nanostructures with interesting properties for applications in the fields of catalysis, electrochemistry, biosensors, and fuel cells. In this paper, we describe a facile and fast nanofabrication method to directly prepare hollow platinum nanoshell tube arrays on a wafer through a galvanic replacement reaction (GRR). A silicon wafer containing an array of copper electrodes and a porous silicon oxide layer is used as a template. In the presence of a gold seed layer, platinum particles were deposited homogeneously on the walls of the submicrometer pores of the template structures to form tubular Pt structures by using copper as the reductant. The reaction parameters, the mechanism, and the properties of the platinum micro/nanotubes are discussed. This method can also be applied to other materials such as gold and silver in order to fabricate nanoshell tube arrays or even bimetal structures. The method is CMOS compatible and thus can be applied onto fully processed CMOS circuits in order to create fully integrated nanosensors or actuators.
A Subsequence-Histogram Method for Generic Vocabulary Recognition over Deletion Channels (2009)

We consider the problem of recognizing a vocabulary--a collection of words (sequences) over a finite alphabet--from a potential subsequence of one of its words. We assume the given subsequence is received through a deletion channel as a result of transmission of a random word from one of the two generic underlying vocabularies. An exact maximum a posterior (MAP) solution for this problem counts the number of ways a given subsequence can be derived from particular subsets of candidate vocabularies, requiring exponential time or space. We present a polynomial approximation algorithm for this problem. The algorithm makes no prior assumption about the rules and patterns governing the structure of vocabularies. Instead, through off-line processing of vocabularies, it extracts data regarding regularity patterns in the subsequences of each vocabulary. In the recognition phase, the algorithm just uses this data, called subsequence-histogram, to decide in favor of one of the vocabularies. We provide examples to demonstrate the performance of the algorithm and show that it can achieve the same performance as MAP in some situations. Potential applications include bioinformatics, storage systems, and search engines.
ChemInform Abstract: SYNTHETIC APPLICATION OF A SUBSTITUENT CONTROLLED CLAISEN REARRANGEMENT. PREPARATION OF ADVANCED CHIRAL INTERMEDIATES FOR THE SYNTHESIS OF PSEUDOMONIC ACIDS (1985)

Abstract Aus dem Dihydropyrandiol‐diacetat (Ia) entsteht der Diester (Ib), der in die Carbon‐ säure (IIa) und weiter in das Methylketon (IIb) übergeführt wird.
The Role of Amino Acids in Skeletal Muscle Adaptation to Exercise (2013)

The synthesis of new protein is necessary for both strength and endurance adaptations. While the proteins that are made might differ, myofibrillar proteins following resistance exercise and mitochondrial proteins and metabolic enzymes following endurance exercise, the basic premise of shifting to a positive protein balance after training is thought to be the same. What is less clear is the contribution of nutrition to the adaptive process. Following resistance exercise, proteins rich in the amino acid leucine increase the activation of mTOR, the rate of muscle protein synthesis (MPS), and the rate of muscle mass and strength gains. However, an effect of protein consumption during acute post-exercise recovery on mitochondrial protein synthesis has yet to be demonstrated. Protein ingestion following endurance exercise does facilitate an increase in skeletal MPS, supporting muscle repair, growth and remodeling. However, whether this results in improved performance has yet to be demonstrated. The current literature suggests that a strength athlete will experience an increased sensitivity to protein feeding for at least 24 h after exercise, but immediate consumption of 0.25 g/kg bodyweight of rapidly absorbed protein will enhance MPS rates and drive the skeletal muscle hypertrophic response. At rest, ∼0.25 g/kg bodyweight of dietary protein should be consumed every 4-5 h and another 0.25-0.5 g/kg bodyweight prior to sleep to facilitate the postprandial muscle protein synthetic response. In this way, consuming dietary protein can complement intense exercise training and facilitate the skeletal muscle adaptive response.
Development of KABISA (2011)

KABISA is a computer-based program for training in diagnostic problems in (sub-) tropical regions. It challenges the individual student with a randomly generated case, for which he should try to find the diagnosis, asking questions, performing a physical examination, and ordering tests. The built-in tutor follows the student’s input with complex logical algorithms and mathematical computations, gives comments and support, and accepts the final diagnosis if sufficient evidence has been built up. Several problems arose with the development. In the first place, the evolution in the teaching of clinical logic is always ahead of the program, so regular updating of the computer logic is necessary. Secondly, the choice of MS Access as computer language has provoked problems of stability, especially the installation of an MSAccess runtime. Thirdly, and most importantly, scholars want proof of the added value of computer programs over classical teaching. Moreover, the concept of a pedagogical “game” is often regarded as childish. Finally, the planning and financing of an “open-ended” pedagogical project is questioned by deciders, as is the case with all operational research.Request access from your librarian to read this chapter's full text.
Risk stratification of smoldering multiple myeloma incorporating revised IMWG diagnostic criteria (2018)

In 2014, the International Myeloma Working Group reclassified patients with smoldering multiple myeloma (SMM) and bone marrow-plasma cell percentage (BMPC%) ≥ 60%, or serum free light chain ratio (FLCr) ≥ 100 or >1 focal lesion on magnetic resonance imaging as multiple myeloma (MM). Predictors of progression in patients currently classified as SMM are not known. We identified 421 patients with SMM, diagnosed between 2003 and 2015. The median time to progression (TTP) was 57 months (CI, 45-72). BMPC% > 20% [hazard ratio (HR): 2.28 (CI, 1.63-3.20); p < 0.0001]; M-protein > 2g/dL [HR: 1.56 (CI, 1.11-2.20); p = 0.01], and FLCr > 20 [HR: 2.13 (CI, 1.55-2.93); p < 0.0001] independently predicted shorter TTP in multivariate analysis. Age and immunoparesis were not significant. We stratified patients into three groups: low risk (none of the three risk factors; n = 143); intermediate risk (one of the three risk factors; n = 121); and high risk (≥2 of the three risk factors; n = 153). The median TTP for low-, intermediate-, and high-risk groups were 110, 68, and 29 months, respectively (p < 0.0001). BMPC% > 20%, M-protein > 2 g/dL, and FLCr > 20 at diagnosis can be used to risk stratify patients with SMM. Patients with high-risk SMM need close follow-up and are candidates for clinical trials aiming to prevent progression.
Precision-Enhanced Differentially-Private Mining of High-Confidence Association Rules (2018)

Association rule mining discovers patterns in large data repositories, and benefits diverse application domains such as healthcare, marketing, etc. However, mining datasets that contain data about individuals may cause significant privacy breaches. Recent research addresses the privacy threats that arise when mining sensitive data, and several techniques allow data mining with differential privacy guarantees. However, existing methods only discover rules that have very large support, i.e., occur in a large fraction of the dataset transactions (typically, more than 50 percent). This is a serious limitation, as numerous high-quality rules do not reach such high frequencies (e.g., rules about rare diseases, or luxury merchandise). We propose a method that focuses on mining high-quality association rules with moderate and low frequencies. We employ a novel technique for rule extraction that combines the exponential mechanism of differential privacy with reservoir sampling. The proposed algorithm allows us to directly mine association rules, without the need to compute noisy supports for large numbers of itemsets. Our experimental evaluation shows that our technique is able to sample low- and moderate-support rules with good precision, clearly outperforming existing solutions.
High-Power Optically Pumped Semiconductor Laser (2009)

We report 23W output from optically pumped semiconductor laser in a near-diffraction limited beam using one OPSL chip in the resonator. The OPSL device needs no antireflective coating, and exploits the strong subcavity gain enhancement.
Characterization of Ligand Effects on Water Activation in Triarylphosphine-Stabilized Pt Nanoparticle Catalysts by X-ray Absorption Spectroscopy (2008)

The synthesis, preparation, and electrochemical characterization of triphenylphosphine triphosphonate (TPPTP) stabilized Pt particles have been reported previously with the observation that the TPPTP ligands increase the specific activity of Pt for the oxygen reduction reaction (ORR). In this work the ORR activity of the Pt/TPPTP electrocatalyst is probed by analyzing water activation with Pt L3-edge X-ray absorption spectroscopy and the EXAFS and Delta XANES analysis techniques. The results are compared with that for similarly prepared Pt/C and Pt stabilized by an oxidized TPPTP ligand (Pt/ox-TPPTP). The Pt particles in the Pt/TPPTP catalyst at 0.54 V (RHE) are complexed via the P (i.e., Pt−P<tp) with about 0.3 ML of TPPTP. Approximately one-half of this converts to a Pt−O−P<tp linkage at 1.0 V; these species exist on the surface along with a dramatically reduced OH coverage. The reduction in OH coverage enhances the surface-specific (ORR) rate relative to the same-sized Pt particles on carbon. The Pt/ox-TPPTP catalysts are linked via a 3-fold coordinated Pt⋮O−P<tp, which severely blocks sites and makes the electrocatalysts almost inactive to water activation and the ORR. The relative importance of site blocking, hydrophobic effects, and electronic effects are discussed with hydrophobic effects believed to dominate in the Pt/TPPTP catalyst and site blocking in the Pt/ox-TPPTP catalyst.
Molecular Characterization of the HIRA Histone Chaperone Complex from Chaetomium thermophilum (2020)

The HIRA histone chaperone complex is an essential epigenetic regulator which deposits the histone variant H3.3 onto DNA to condense it into chromatin and to regulate the epigenetic landscape of the cell. Because the HIRA complex and H3.3 deposition is associated with areas of active transcription in the genome, HIRA dysregulation is associated with disordered development, aging, and maintenance of terminally differentiated cell types. The goal of our studies is to understand the molecular basis of H3.3‐specific histone deposition by the HIRA complex. Toward this goal, we recombinantly express orthologs of the four HIRA complex components‐ HIRA, UBN1, CABIN1, and ASF1a‐ from the thermophilic fungus Chaetomium thermophilum for biochemical and structural characterization. We show efficient recombinant expression of each subunit, determine complex stoichiometry using analytical ultracentrifugation, and begin structural analysis using a combination of X‐ray crystallography and cryo‐electron microscopy of the subunits alone, in complex, and with histones. Support or Funding Information Structural Biology and Molecular Biophysics Training Program, NIH 5‐T32‐GM‐008275‐29; Epigenetics of Aging and Age‐Associated Diseases P01, NIH 5P01AG031862‐12