gebhart/patrepeval huggingface dataset:
Processible Polyacetylene-Based &#x003C7;<sup>(3)</sup> Materials for Photonic Applications (2007)

A number of processing variations were carried out to optimize the morphology, third- order nonlinearity, and processability of substituted polyacetylene polymers. This allowed for spin coating of optical quality films with large nonlinearities.
d-Sotalol reduces heart rate in vivo through a β-adrenergic receptor–independent mechanism (1993)

d-Sotalol was developed as an antiarrhythmic agent with a relative lack of antagonist activity at beta-adrenergic receptors. Exercise heart rate reduction has been observed after administration to humans. The purpose of this study was to determine directly whether this effect of d-sotalol was attributable to beta-blockade. Plasma samples from normal volunteers who randomly received either atenolol, d-sotalol, or placebo were used in an in vitro radioreceptor assay to determine occupancy of beta 1-adrenergic receptors by antagonist present in the plasma. Occupancy was compared with the observed pharmacologic effects. A reduction in exercise heart rate of 7.7% +/- 3.8% for d-sotalol and 15.9% +/- 3.0% for atenolol occurred with beta 1-adrenergic receptor occupancy of 0% and 33.9% +/- 21.4%, respectively. Absence of antagonist effect in the radioreceptor assay eliminates the potential role of beta 1-blockade in d-sotalol-induced heart rate reduction. This effect is most likely a result of prolongation of the sinus node action potential duration.
PYY3‐36 as an anti‐obesity drug target (2005)

The neuropeptide Y (NPY)/peptide YY (PYY) system has been implicated in the physiology of obesity for several decades. More recently ignited enormous interest in PYY3-36, an endogenous Y2-receptor agonist, as a promising anti-obesity compound. Despite this interest, there have been remarkably few subsequent reports reproducing or extending the initial findings, while at the same time studies finding no anti-obesity effects have surfaced. Out of 41 different rodent studies conducted (in 16 independent labs worldwide), 33 (83%) were unable to reproduce the reported effects and obtained no change or sometimes increased food intake, despite use of the same experimental conditions (i.e. adaptation protocols, routes of drug administration and doses, rodent strains, diets, drug vendors, light cycles, room temperatures). Among studies by authors in the original study, procedural caveats are reported under which positive effects may be obtained. Currently, data speak against a sustained decrease in food intake, body fat, or body weight gain following PYY3-36 administration and make the previously suggested role of the hypothalamic melanocortin system unlikely as is the existence of PYY deficiency in human obesity. We review the studies that are in the public domain which support or challenge PYY3-36 as a potential anti-obesity target.
Mentoring: or 'how was it for you?' (2008)

Abstract: This panel session is designed to give a practical insight into setting up a mentoring realtionship and reflecting on experience from different countries of the mentoring process itself from both a mentor and a mentee perspective. Each member of the panel will give a short presentation to highlight some key points, and then the discussion will be opened up to the audience. The session will be of interest to those involved in a mentoring relationship and those interested in doing so.
Brain Activations during Judgments of Positive Self-conscious Emotion and Positive Basic Emotion: Pride and Joy (2007)

We aimed to investigate the neural correlates associated with judgments of a positive self-conscious emotion, pride, and elucidate the difference between pride and a basic positive emotion, joy, at the neural basis level using functional magnetic resonance imaging. Study of the neural basis associated with pride might contribute to a better understanding of the pride-related behaviors observed in neuropsychiatric disorders. Sixteen healthy volunteers were studied. The participants read sentences expressing joy or pride contents during the scans. Pride conditions activated the right posterior superior temporal sulcus and left temporal pole, the regions implicated in the neural substrate of social cognition or theory of mind. However, against our prediction, we did not find brain activation in the medial prefrontal cortex, a region responsible for inferring others' intention or self-reflection. Joy condition produced activations in the ventral striatum and insula/operculum, the key nodes of processing of hedonic or appetitive stimuli. Our results support the idea that pride is a self-conscious emotion, requiring the ability to detect the intention of others. At the same time, judgment of pride might require less self-reflection compared with those of negative self-conscious emotions such as guilt or embarrassment.
Ultraviolet to infrared downshifting in Ce and Yb co-doped aluminum oxynitride thin films (2019)

Abstract We report for the first time on ultraviolet (UV) to near infrared (NIR) downshifting between cerium, Ce, and ytterbium, Yb, in aluminum oxynitride, Al(O)N, thin films prepared by the reactive magnetron sputtering technique. The crystal structure of the prepared samples has been investigated by x-ray diffraction and transmission electron microscopy. In addition, the content of Ce and Yb were determined by Rutherford backscattering spectrometry. The role of Ce in downshifting the absorbed excitation UV photons into NIR ones is supported by photoluminescence (PL) and PL excitation measurements of (Ce, Yb) co-doped samples. Time-resolved PL along with PL power-dependent measurements propose that a one-to-one photon mechanism is achieved through charge transfer state mediation. The present findings contribute to the racetrack of down-conversion (DC) solar cell topic by investigating such a DC phenomenon in a new matrix, Al(O)N.
<title>Multiphoton up-converting phosphors for use in rapid immunoassays</title> (2000)

There exists increasing demand for rapid in-vitro diagnostic test capable of detecting pathogens, disease markers, and drugs. Many currently marketed technologies are limiting due to their analytical sensitivity or the number of analytes detected in a single assay. Presented is the use of up- converting phosphors as reporters in rapid point-of-care diagnostic assays using a lateral flow format in a nitrocellulose matrix. Up-converting Phosphor Technology (UPT) utilizes lanthanide-doped ceramic particles that possess anti-Stokes shift emission. These material absorb multiple IR photons and emit dopant-dependent spectra in the visible range. Their signature spectra allow the development of sensitive, multi-analyte diagnostic test. Because no biological matrix up-converts in the IR, the sensitivity of the assay is enhanced, being determined by the affinity of the biological constituents and the level of non-specific binding of the particle reporter. Feasibility data presented below represent a wide range of molecular weight analytes, including drugs of abuse, proteins such as cardiac markers, and pathogenic microorganisms.
Deep Networks With Large Output Spaces (2014)

Deep neural networks have been extremely successful at various image, speech, video recognition tasks because of their ability to model deep structures within the data. However, they are still prohibitively expensive to train and apply for problems containing millions of classes in the output layer. Based on the observation that the key computation common to most neural network layers is a vector/matrix product, we propose a fast locality-sensitive hashing technique to approximate the actual dot product enabling us to scale up the training and inference to millions of output classes. We evaluate our technique on three diverse large-scale recognition tasks and show that our approach can train large-scale models at a faster rate (in terms of steps/total time) compared to baseline methods.
Effect of Acceptor (Mg) Concentration on the Resistance Degradation Behavior in Acceptor (Mg)‐Doped BaTiO 3 Bulk Ceramics: I. Impedance Analysis (2009)

Degradation behavior of the electrical resistance of acceptor (Mg)‐doped BaTiO 3 ceramics was contrasted against different acceptor concentrations. Coarse‐grained specimens with uniform grain sizes and different acceptor concentrations were prepared by sintering both in air and a reducing atmosphere. The specimens sintered under both atmospheres showed similar trends in the degradation behavior with a critical dependence on the acceptor concentration. The time to degradation decreased systematically with the increase of acceptor concentration. An impedance spectroscopy study was conducted on these samples at various temperatures. An equivalent circuit analysis of these data was considered, from which bulk and grain‐boundary conductivity was determined for each composition as a function of grain size. Attempts were made also to determine the ionic conductivity for the different samples as a function of temperature and doping concentration.
HAND SURGERY UNDER WRIST BLOCK AND LOCAL INFILTRATION ANESTHESIA, USING AN UPPER ARM TOURNIQUET (1972)

DUPONT, CLAUDE M.D.; CIABURRO, HUGO M.D.; PRÉVOST, YVES M.D.; CLOUTIER, GEORGES M.D. Author Information
ENHANCED HIERARCHICAL SHAPE MATCHING FOR SHAPE TRANSFORMATION (2003)

The quality of 3D object transformation very often relies on the quality of the matching between the two objects. Geometric considerations regarding scale, rotation and translation, and user defined constraints are used to control the matching. Nevertheless, more complex measures regarding volumetric or topological similarity between the shapes are more difficult to define even manually. Choosing an appropriate representation can assist in finding more robust definitions for such measures resulting in an enhanced and comprehensive automatic matching algorithm. In this paper we present a hierarchal union of spheres object representation. The underlying topology of this volumetric representation can be defined as a distinct skeletal model, the zero alpha-shape. This structure can then be used to find better matching and yield better transformations when complex topologies are involved. Our shape matching approach begins by defining a hierarchical model on top of the zero alpha shape, which induces a hierarchy on the union of spheres. Shape matching and alignment including topology and volume constraints are solved progressively while traversing this hierarchy.
Supplementary Table 2 from Interleukin-6 and Oncostatin-M Synergize with the PI3K/AKT Pathway to Promote Aggressive Prostate Malignancy in Mouse and Human Tissues (2023)

&lt;p&gt;XLSX file - 12K, Quantification of phenotypes observed in human samples across four histological sections from independent biological replicates.&lt;/p&gt;
Integration Technique of Surgical Information in Real/Virtual Space (2003)

Recently, digital system of clinical record is widely used for the convenience of hospital management. Whereas, in terms of the digital record of diagnosis, therapy, and surgery, the interface to input clinical operations is not enough on simpleness and swiftness. To manage and analyze surgical information totally, we have been developing a total computer management system of surgical information which includes quantifications of pre-/post-diagnosis and surgery and a framework of surgical reporting. In this paper, we show results of our researches and its effectiveness.
Design Guidelines and Full-Scale Verification for MSE Walls with Traffic Barriers (2011)

Millions of square meters of mechanically stabilized earth (MSE) retaining walls are constructed annually in the United States. For highway applications, a roadside barrier system is placed at the edge of the wall. This barrier system generally consists of an L-shape concrete structure so that if a vehicle hits the vertical part of the L shape (barrier), the horizontal part of the L (moment slab) provides the resisting moment during the impact. This impact must be resisted by the soil, the reinforcement, and the panels in the MSE wall. This paper gives guidelines on how to design the reinforcement for pullout and yielding and the panels for flexural and shear failure. It also gives the guidelines on how to ensure the stability of the barrier. These design guidelines are developed in terms of AASHTO load and resistance factor design procedures. In a second part, a full-scale crash test on an instrumented 2.79 m high MSE wall is described and analyzed. The wall and barrier behaved very satisfactorily and represented a verification of the proposed guidelines. Pressure distributions are presented for designing the top two layers of wall reinforcement to resist barrier impact forces. A 44.5-kN static equivalent load is recommended for evaluating the stability of the barrier and moment slab system.
The impact of software radio on wireless networking (1999)

A software radio is a wireless communications device in which some or all of the physical layer functions are implemented in software. The flexibility provided by the software implementation enables a single device to interoperate with other devices using different wireless physical layer technologies, by simply invoking the appropriate software. A mobile computing device equipped with a software radio would have access to a wide range of connectivity options including cellular, wireless LAN and satellite systems. This would not only enable seamless anytime, anywhere connectivity, but also provide users the flexibility of choosing from the available connectivity options to best suit their price/performance requirements. Most software radio research to date has been driven by military and commercial cellular applications. Mobile networking applications require additional functionality present new software radio design constraints. This paper reviews existing software radio research, describes the SpectrumWare software radio system and identifies some important research challenges that must be addressed in order to apply software radio research to mobile networking applications.
Improving thermal and chemical stabilities of electronic epoxies using polysiloxane copolymers - Part I: core-shell particles (2021)

Improving thermal and chemical stabilities of electronic epoxies using polysiloxane copolymers
Optomagnetic field in nonmagnetic plasmonic nanostructures (2021)

International audience
Fault identification in distribution systems using maximum overlap wavelet decomposition (2017)

This paper presents a novel voltage-based protection element using MODWT wavelet coefficients. This helps improve the sensitivity of existing current-based protection which can be subjected to sensitivity issues given the evolving distribution grids with multiple generation sites. The analysis of the voltage transient immediately after a disturbance can provide much useful information about the nature of the disturbance, which may otherwise be hidden. Therefore, augmenting transient based fault detection to existing techniques can improve the system protection. The proposed algorithm analyses the relative and individual content of high and low wavelet-level coefficients to reliably detect faults, and not trigger during non-fault disturbances like capacitor switching. The performance of the element is validated using results from power system simulation models and field event reports.
<title>Chronocolor FLC devices for high-resolution projection displays</title> (1998)

We describe a single panel SXGA projection display based on active matrix ferroelectric liquid crystal (FLC) technology. The FLC light-modulating layer is placed on top of a reflective CMOS backplane. This geometry effectively takes advantage of the fast switching sped and high resolution possible in a submicron thick layer of FLC and fine design rules available in standard CMOS fabs. The fast FLC switching speed allows both gray scale and color to be generated with time sequential addressing. Current FLC materials are well suited to operation with mainstream 5 volt CMOS processes and offer a clear path to compatibility with newer 3.3 and 2.5 V processes. These lower voltages result in lower power consumption and finer design rules allowing for higher density of on-chip electronics such as MPEG2. The reflective quarter wave plate design of the display affords a large angular acceptance resulting in flexibility of optical design as well as excellent contrast and throughput vs. viewing angle. We describe this color projection display and the high temperature FLC materials and mixtures optimized for them.
A Survey of the Existing Landscape of ML Systems (2015)

We survey the existing landscape of ML systems to identify gaps that motivate our vision of a unifying abstraction to support the iterative process of model selection and lay a principled foundation for model selection management systems.
Hybrid position/force control of an active handheld micromanipulator for membrane peeling (2015)

A hybrid position/force control system has been implemented that successfully attenuates forces and minimizes unwanted excursions during microsurgical procedures such as membrane peeling. Results also suggest that improvements in safety using this technique may be attained without increasing the duration of the procedure.
PSMA-Specific CAR-Engineered T Cells Eradicate Disseminated Prostate Cancer in Preclinical Models (2014)

Immunology-based interventions have been proposed as a promising curative chance to effectively attack postoperative minimal residual disease and distant metastatic localizations of prostate tumors. We developed a chimeric antigen receptor (CAR) construct targeting the human prostate-specific membrane antigen (hPSMA), based on a novel and high affinity specific mAb. As a transfer method, we employed last-generation lentiviral vectors (LV) carrying a synthetic bidirectional promoter capable of robust and coordinated expression of the CAR molecule, and a bioluminescent reporter gene to allow the tracking of transgenic T cells after in vivo adoptive transfer. Overall, we demonstrated that CAR-expressing LV efficiently transduced short-term activated PBMC, which in turn were readily stimulated to produce cytokines and to exert a relevant cytotoxic activity by engagement with PSMA+ prostate tumor cells. Upon in vivo transfer in tumor-bearing mice, CAR-transduced T cells were capable to completely eradicate a disseminated neoplasia in the majority of treated animals, thus supporting the translation of such approach in the clinical setting.
Two New Rearranged Taxoids from Taxus wallichiana Zucc. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Dual-band antenna system for SDARS and GPS applications (2010)

This paper presents a dual frequency band circularly polarized antenna system for Satellite Digital Audio Radio Service (SDARS) and Global Positioning System (GPS) applications. The proposed dual band antenna system consists of two circular patches each having four perpendicular slots for operating in two different frequency bands with left-handed circular polarization (LHCP) for SDARS and a right-handed circular polarization (RHCP) for GPS. The circular polarization characteristics for both antennas are obtained by choosing appropriate lengths of four perpendicular slots on the circular patches. The LHCP or RHCP radiation is readily obtained by selecting the proper feeding location. Results are presented in terms of the |S11|, radiation pattern and axial ratio.
Functional invadopodia formed in glioblastoma stem cells are important regulators of tumor angiogenesis (2018)

Glioblastoma (GBM) represents the most common and lethal brain tumor. High vascularization, necrosis and invasiveness are hallmarks of GBM aggressiveness with recent data suggesting the important role of glioblastoma stem cells (GSCs) in these processes. It is now well established that cancer cells employ specialized structures termed invadosomes to potentiate invasion. However, the role of these structures in GBM dissemination remains poorly investigated. In this study, we showed that GBM-isolated GSCs form invadopodia-like protrusions endowed with degradative action. Interestingly, their formation depends on extracellular matrix (ECM) sensing via the CD44 receptor. We also found that GSCs invasive migration occurring during tubes assembly is promoted through invadopodia-mediated-ECM remodeling and LIM kinases signaling. Moreover, our study demonstrates that GSCs are highly adaptable cells that are able not only to restore damaged endothelial-derived tubes but also to generate in cooperation with normal endothelial cells (ECs) intact vascular channels. Taken together, our data provide new insights in GBM microvasculature and suggest that GSCs targeting in combination with anti-VEGF therapy may block tumor progression.
Tumor necrosis factor-alpha in pregnant cattle after intravenous or subcutaneous vaccination with Brucella abortus strain RB51. (1998)

s.c. vaccination for prevention of brucellosis, using recommended adult dosages, does not result in increase of TNF-alpha concentration in plasma, serum, or placental fluids; however, vaccination of pregnant cattle stimulates trophoblastic epithelial cells to express TNF-alpha, although the physiologic and quantitative importance of this expression remains unknown.
Optimization-based Coordination and Control of Traffic Lights and Mixed Traffic in Multi-Intersection Environments (2023)

Coordinating the flow of traffic through urban areas with multiple intersections is a complex problem whose solution has the potential to improve safety, increase throughput, and optimize energy efficiency. In addition to controlling traffic lights, the introduction of connected and automated vehicles (CAVs) offers opportunities in terms of additional sensing and actuation points within the traffic network. This paper proposes a centralized and a decentralized implementation for the joint coordination and control of both traffic signals and mixed traffic, including CAVs and human driven vehicles (HDVs), in a network of multiple connected traffic intersections. Mixed-integer linear programming (MILP) is used to compute safe control trajectories for both CAVs and traffic light signals, which minimize overall congestion and fuel consumption. Our approaches are validated using extensive traffic simulations on the SUMO platform and they are shown to provide improvements of around 32-60%, 90-96% and 40-60% in travel time, waiting time and fuel consumption, respectively, when compared to gap-based adaptive and timed traffic lights.
Secreted int-1 Protein Is Associated with the Cell Surface (1990)

The murine int-1 proto-oncogene has been implicated in neural development and, when transcriptionally activated by mouse mammary tumor virus, contributes to the genesis of mammary tumors. To understand the function of the int-1 gene product in these processes, we have characterized the biochemical properties of int-1 protein expressed in a neuroendocrine cell line transfected with int-1 cDNA. Here we provide evidence that int-1 protein is secreted and associates with the cell surface. int-1 protein was very efficiently processed and secreted through the constitutive secretory pathway, although no int-1 protein could be immunoprecipitated from the culture medium. Treatment with suramin effectively released mature int-1 proteins into the culture fluid, which suggests that secreted int-1 protein associates with the cell surface or extracellular matrix. We have also shown directly, by radioiodination of intact cells and by surface antibody adsorption, that secreted int-1 proteins can be detected on the cell surface. These data support a model in which int-1 protein is secreted and functions locally in cell-to-cell signaling.