gebhart/patrepeval huggingface dataset:
Pilot Study of Anti-Th2 Immunotherapy for the Treatment of Breast Cancer-Related Upper Extremity Lymphedema (2021)

Recent studies suggest that Th2 cells play a key role in the pathology of secondary lymphedema by elaborating cytokines such as IL4 and IL13. The aim of this study was to test the efficacy of QBX258, a monoclonal IL4/IL13 neutralizing antibody, in women with breast cancer-related lymphedema (BCRL). We enrolled nine women with unilateral stage I/II BCRL and treated them once monthly with intravenous infusions of QBX258 for 4 months. We measured limb volumes, bioimpedance, and skin tonometry, and analyzed the quality of life (QOL) using a validated lymphedema questionnaire (Upper Limb Lymphedema 27, ULL-27) before treatment, immediately after treatment, and 4 months following treatment withdrawal. We also obtained 5 mm skin biopsies from the normal and lymphedematous limbs before and after treatment. Treatment was well-tolerated; however, one patient with a history of cellulitis developed cellulitis during the trial and was excluded from further analysis. We found no differences in limb volumes or bioimpedance measurements after drug treatment. However, QBX258 treatment improved skin stiffness (<i>p</i> < 0.001) and improved QOL measurements (Physical <i>p</i> < 0.05, Social <i>p</i> = 0.01). These improvements returned to baseline after treatment withdrawal. Histologically, treatment decreased epidermal thickness, the number of proliferating keratinocytes, type III collagen deposition, infiltration of mast cells, and the expression of Th2-inducing cytokines in the lymphedematous skin. Our limited study suggests that immunotherapy against Th2 cytokines may improve skin changes and QOL of women with BCRL. This treatment appears to be less effective for decreasing limb volumes; however, additional studies are needed.
Surface Micromachined Dielectrophoretic Gates for the Front-End Device of a Biodetection System (2005)

We present a novel separation device for the front-end of a biodetection system to discriminate between biological and non-biological analytes captured in air samples. By combining AC dielectrophoresis along the flow streamlines and a field-induced phase-separation, the device utilizes “dielectrophoretic gating”to separate analytes suspended in a flowing fluid based on their intrinsic polarizability properties. The gates are integrated into batch fabricated self-sealed surface-micromachined fluid channels. We demonstrate that setting the gate to a moderate voltage in the radio frequency range removed bacteria cells from a mixture containing non-biological particles without the need for fluorescent labeling or antibody-antigen hybridization, and also validate experimentally basic relations for estimating the gate performance.
A comparative study on the deposition of Mn12single molecule magnets on the Au(111) surface (2008)

Different approaches to the deposition of Mn(12) single molecule magnets on the Au(111) surface and their characterization by a broad variety of techniques are investigated with respect to their suitability for a profound corroboration of the integrity of the Mn(12) core. In this context, the most recent improvements in the experimental approaches are presented and the latest results on the electronic properties of Mn(12) are linked to each other. The results confirm the high instability of Mn(12) single molecule magnets on surfaces and reveal the need for an amendment of the requirements to define the structural integrity of Mn(12) molecules on surfaces.
ABCB5 Identifies Immunoregulatory Dermal Cells (2015)

Cell-based strategies represent a new frontier in the treatment of immune-mediated disorders. However, the paucity of markers for isolation of molecularly defined immunomodulatory cell populations poses a barrier to this field. Here, we show that ATP-binding cassette member B5 (ABCB5) identifies dermal immunoregulatory cells (DIRCs) capable of exerting therapeutic immunoregulatory functions through engagement of programmed cell death 1 (PD-1). Purified Abcb5(+) DIRCs suppressed T cell proliferation, evaded immune rejection, homed to recipient immune tissues, and induced Tregs in vivo. In fully major-histocompatibility-complex-mismatched cardiac allotransplantation models, allogeneic DIRCs significantly prolonged allograft survival. Blockade of DIRC-expressed PD-1 reversed the inhibitory effects of DIRCs on T cell activation, inhibited DIRC-dependent Treg induction, and attenuated DIRC-induced prolongation of cardiac allograft survival, indicating that DIRC immunoregulatory function is mediated, at least in part, through PD-1. Our results identify ABCB5(+) DIRCs as a distinct immunoregulatory cell population and suggest promising roles of this expandable cell subset in cellular immunotherapy.
Ion Mobility Spectrometry (IMS) (2016)

This document contains recommendations for terminology in mass spectrometry. Development of standard terms dates back to 1974 when the IUPAC Commission on Analytical Nomenclature issued recommendations on mass spectrometry terms and definitions. In 1978, the IUPAC Commission on Molecular Structure and Spectroscopy updated and extended the recommendations and made further recommendations regarding symbols, acronyms, and abbreviations. The IUPAC Physical Chemistry Division Commission on Molecular Structure and Spectroscopy’s Subcommittee on Mass Spectroscopy revised the recommended terms in 1991 and appended terms relating to vacuum technology. Some additional terms related to tandem mass spectrometry were added in 1993 and accelerator mass spectrometry in 1994. Owing to the rapid expansion of the field in the intervening years, particularly in mass spectrometry of biomolecules, a further revision of the recommendations has become necessary. This document contains a comprehensive revision of mass spectrometry terminology that represents the current consensus of the mass spectrometry community.
Conformational and ion binding properties of a cyclic octapeptide, cyclo(Ala‐Leu‐Pro‐Gly)2 (1992)

The conformation and ion-binding characteristics of a cyclic octapeptide, cyclo (Ala-Leu-Pro-Gly)2, in a liphophilic solvent, acetonitrile, have been studied using CD and nmr spectroscopy. The peptide binds preferentially to divalent cations such as calcium, magnesium, and barium. The conformations of the free cyclic peptide and its calcium complex are very similar with well-defined beta- and gamma-turns. The cyclic peptide readily forms equimolar and possibly 2:1 (peptide:cation) complexes with divalent cations.
Commentary: assessment of non‐alcoholic fatty liver disease using serum total cell death and apoptosis markers – authors’ reply (2012)

We thank Miller and Dillon for their comments.1 Their first point was on the definition of non-alcoholic steatohepatitis (NASH) and whether some NASH patients might have non-alcoholic fatty liver disease activity score (NAS) below 5 points. Among 69 patients classified as NASH in our study, 32 (46%) had NAS over 5 points.2 While we agree with Miller and Dillon that the inclusion of less florid cases in the NASH group might lead to lower apparent diagnostic accuracy of the cytokeratin-18-based cell death biomarkers, the meaning of NAS deserves clarification. According to current guidelines, NASH is a histological diagnosis based on global features of hepatic steatosis, inflammation and hepatocyte ballooning.3 In contrast, NAS is the unweighted sum of the scores of these 3 histological parameters. NAS was originally developed by the NASH Clinical Research Network (CRN) to assess treatment response in NASH trials.4 However, since its introduction, many hepatologists have mistaken its meaning and used a cut-off of 5 points to diagnose NASH. A number of subsequent studies suggest that this approach is inappropriate. When pathologists from the NASH CRN reviewed the histology and clinical data of 976 adult NAFLD patients, only 75% of patients with definite NASH had NAS above 5, and at least 29% of patients with NAS below 5 had NASH.5 In an independent study of 386 adult patients, NAS was again shown to have only moderate correlation with the diagnosis of NASH.6, 7 Finally, we agree that one of the important roles of new biomarkers of NASH is to monitor disease activity over time because serial liver biopsies are unrealistic outside research setting.8, 9 Further studies should be conducted to evaluate the performance of biomarkers against serial biopsies. This will eventually reduce the need for liver biopsy and improve patient care. The authors’ declarations of personal and financial interests are unchanged from those in the original article.2
Development of a Microchip-Based Bioassay System Using Cultured Cells (2005)

We developed a novel bioassay system using a glass microchip and cultured cells. A microchamber for cell culture and microchannels for reactions and detection were fabricated on a Pyrex glass substrate by photolithography and wet etching techniques. Cell culture, chemical and enzymatic reactions, and detection were integrated into the microchip. To keep different temperatures locally in three areas of the microchip, we designed and fabricated a temperature control device. Nitric oxide released from macrophage-like cells stimulated by lipopolysaccharide was successfully monitored with the microchip, the temperature control device, and a thermal lens microscope. The total assay time was reduced from 24 to 4 h, and detection limit of NO was improved from 1 x 10(-6) to 7 x 10(-8) M compared with conventional methods. Moreover, the system could monitor a time course of the release, which is difficult to measure by conventional batch methods. We conclude that this system is promising for a rapid bioassay system with very small consumption of cells.
Binary Forensic Code for Multimedia Signals: Resisting Minority Collusion Attacks (2009)

Digital forensic marking is a technology to discourage unauthorized redistribution of multimedia signals by embedding a unique mark into each user’s copy of the content. A powerful class of attacks on forensic marking is the collusion attack by a group of users. Recently, a new collusion attack, called the minority attack, has been proposed against forensic marking schemes with correlation-based detectors. Although this attack is not very effective on Gaussian-based forensic marking, it is quite powerful on removing the traces of users when the forensic marking is binary. In this paper, we first study the performance of an ECC-based binary forensic code under the minority attack and we model the additional processing, such as compression, applied on colluded copy as a binary symmetric channel. We confirm that the system can be defeated by a minority attack from only 3 colluders. To resist the minority attack, we propose a row-permuted binary orthogonal code to serve as the inner code for ECC-based forensic code, coupled with an adaptive detector. Experimental results show that the proposed scheme has a significantly improved resistance to a minority attack.
Computer Model of Ventricular Interaction During Left Ventricular Circulatory Support (1989)

The authors used a computer model of the heart and circulation to test the hypothesis that anatomic ventricular interactions are responsible for the observed instances of right ventricular failure during use of a left ventricular assist device. The model predicts that left ventricular pressure-unloading with a LVAD, in the presence of isolated systolic interaction, results in impairment of RV function, whereas with isolated diastolic interaction, RV function is improved. Due to competition between these two interactions, there is a negligible overall effect of ventricular anatomic interactions in determining right ventricular function in the normal heart.
Characterizing and Exploiting Reference Locality in Data Stream Applications (2006)

In this paper, we investigate a new approach to process queries in data stream applications. We show that reference locality characteristics of data streams could be exploited in the design of superior and flexible data stream query processing techniques. We identify two different causes of reference locality: popularity over long time scales and temporal correlations over shorter time scales. An elegant mathematical model is shown to precisely quantify the degree of those sources of locality. Furthermore, we analyze the impact of locality-awareness on achievable performance gains over traditional algorithms on applications such asMAX-subset approximate sliding window join and approximate count estimation. In a comprehensive experimental study, we compare several existing algorithms against our locality-aware algorithms over a number of real datasets. The results validate the usefulness and efficiency of our approach.
Mosquitocidal Chips Containing the Insect Growth Regulator Pyriproxyfen for Control of Aedes aegypti (Diptera: Culicidae) (2019)

<i>Aedes aegypti</i> were exposed to water treated with mosquitocidal chips containing the insecticide pyriproxyfen in a polymer formulation. Chips were tested under different conditions; different water volumes, in containers made of different material, and in water with different levels of organic matter. Treated chips caused 100% mortality of <i>Ae. aegypti</i> during their pupal stage independent of size or type of container, and the mount of organic matter contained in the water to which the mosquito larvae were exposed. When mosquitocidal chips were used in >25% of the oviposition containers within their cages, there was a significant control of the mosquito populations. Mosquitocidal chips worked in different environments, caused significant mosquito population decreases, and were effective in controlling <i>Ae. aegypti.</i>
Advances in microwave MCM‐D technology (2000)

The thin film multilayer multichip module technology (MCM‐D) was originally used for the interconnection of high speed digital circuits in a single module. Nowadays, the technology is more and more evolving towards use in the interconnection of RF and microwave circuits with integrated passive components. This paper gives an overview of this evolution towards microwave MCM‐D technology and the recent advances with respect to the integration of high quality passive components. With a discussion on the flip chip mounting of active devices, the link towards fully integrated high frequency front‐end systems is pointed out.
Predictors of Survival After Surgical Treatment of Spinal Metastasis (2011)

We identified the Charlson Comorbidity Index score as one of the strongest predictors of survival after surgery for spinal metastasis. We confirmed previous findings that radiosensitivity of the tumor and ambulatory status are significant predictors of survival.
Thermoelectric Tin Selenide: The Beauty of Simplicity (2014)

A thermoelectric figure of merit that is unprecedentedly high has been observed in SnSe crystals. This finding suggests that bulk materials with a layered structure and highly anharmonic lattice vibrations can feature an intrinsically low thermal conductivity and high thermoelectric efficiency. Together with other recent findings in this field, it urges us to revisit basic design principles for thermoelectric materials.
Understanding the Charge‐Transfer State and Singlet Exciton Emission from Solution‐Processed Small‐Molecule Organic Solar Cells (2014)

Electroluminescence (EL) from the charge-transfer state and singlet excitons is observed at low applied voltages from high-performing small-molecule bulk-heterojunction solar cells. Singlet emission from the blends emerges upon altering the processing conditions, such as thermal annealing and processing with a solvent additive, and correlates with improved photovoltaic performance. Low-temperature EL measurements are utilized to access the physics behind the singlet emission.
Supplementary Table 2 from An Antimesothelin-Monomethyl Auristatin E Conjugate with Potent Antitumor Activity in Ovarian, Pancreatic, and Mesothelioma Models (2023)

&lt;p&gt;Supplementary Table 2: Details of in vivo efficacy studies (# cells implanted; mouse strain, age and weight; tumor randomization volumes and IHC scores; % tumor growth inhibition and time to doubling versus vehicle).&lt;/p&gt;
Development of dietary soluble fibres by enzymatic synthesis and assessment of their digestibility in in vitro, animal and randomised clinical trial models (2017)

The aim was to develop novel fibres by enzymatic synthesis, to determine their total dietary fibre by AOAC method 2009.01 and to estimate their potential digestibility and assess their digestibility in vivo using glycaemic and insulinaemic responses as markers in mice and randomised clinical trial models. We found that fibre candidates to which α-(1,2) branching was added were resistant to digestion in the mouse model, depending on the amount of branching. These results show that in vivo models are needed to reliably assess the digestibility of α-glycosidic-linked oligomeric dietary fibre candidates, possibly due to absence of brush border α-glucosidase activity in the current in vitro assessment. α-(1,3)-linked and α-(1,6)-linked glucose oligomers were completely digested in humans and mice. In conclusion, it is possible to develop dietary soluble fibres by enzymatic synthesis. Adding α-(1,2) branching increases their resistance to digestion in vivo and can thus improve their suitability as potential fibre candidates. Clinical Trial Registry: ClinicalTrials.gov, NCT02701270.
SOLID PHASE MICROBIAL REACTIONS OF SEX HORMONE, TRANS-ANDROSTERONE WITH FILAMENTOUS FUNGI (2014)

Objective: A microbial biotransformation study was performed on trans -androsterone ( 1 ) using solid phase medium. In the present context, trans -androsterone ( 1 ), a sex hormone was fermented with two filamentous fungi, Rhizopus stolonifer (black bread mold) and Fusarium lini . Methods: Sabouraud-4% glucose-agar were used to cultivate the fungal cultures as solid phase medium. Substrate 1 was incubated with R. stolonifer (ATCC 10404) and F. lini (NRRL 68751) for 8 days. Microbial transformed metabolites were purified by using column chromatographic technique. Results: The metabolism study of 1 revealed that various metabolites were detected when incubated with filamentous fungi. A total of 3 transformed products were obtained. The reactions occurred that exhibited diversity; including selective hydroxylation at C-6 and C-7 along with oxidation occurs at C-3 positions. Their structure and identified on the basis of extensive spectroscopic data (NMR, HREIMS, IR and UV) as 3b,7b-dihydroxy-5a-androstan-17-one 2 in a good yield (58%), 6b-hydroxy-5a-androstan-3,17-dione 3 , and 3b,6b-dihydroxy-5a-androstan-17-one 4. Conclusion: Solid phase microbial transformation method can successfully be used for the development of new steroidal drugs. The modified steroidal molecules could favor when compared to their natural counterparts due to several medicinal advantages.
Fischer-type carbene complexes as potential molecular-systems for nonlinear-optical materials (1995)

Specifically tailored Fischer-type carbene complexes have been synthesised and evaluated as simple &lt;&gt; organometallic species with potential second-order NLO properties
Common Laboratory Mice Are Susceptible to Infection with the SARS-CoV-2 Beta Variant (2021)

Small animal models are of crucial importance for assessing COVID-19 countermeasures. Common laboratory mice would be well-suited for this purpose but are not susceptible to infection with wild-type SARS-CoV-2. However, the development of mouse-adapted virus strains has revealed key mutations in the SARS-CoV-2 spike protein that increase infectivity, and interestingly, many of these mutations are also present in naturally occurring SARS-CoV-2 variants of concern. This suggests that these variants might have the ability to infect common laboratory mice. Herein we show that the SARS-CoV-2 beta variant attains infectibility to BALB/c mice and causes pulmonary changes within 2-3 days post infection, consistent with results seen in other murine models of COVID-19, at a reasonable virus dose (2 × 10<sup>5</sup> PFU). The findings suggest that common laboratory mice can serve as the animal model of choice for testing the effectiveness of antiviral drugs and vaccines against SARS-CoV-2.
Optimizing Fiducial Marker Placement for Improved Visual Localization (2022)

Adding fiducial markers to a scene is a well-known strategy for making visual localization algorithms more robust. Traditionally, these marker locations are selected by humans who are familiar with visual localization techniques. This paper explores the problem of automatic marker placement within a scene. Specifically, given a predetermined set of markers and a scene model, we compute optimized marker positions within the scene that can improve accuracy in visual localization. Our main contribution is a novel framework for modeling camera localizability that incorporates both natural scene features and artificial fiducial markers added to the scene. We present optimized marker placement (OMP), a greedy algorithm that is based on the camera localizability framework. We have also designed a simulation framework for testing marker placement algorithms on 3D models and images generated from synthetic scenes. We have evaluated OMP within this testbed and demonstrate an improvement in the localization rate by up to 20 percent on four different scenes.
Désoccultation de cartes de profondeurs pour la synthèse de vues virtuelles (2016)

National audience
Investigation of the effect of the dual orexin receptor antagonist almorexant on ophthalmological, spermatogenic, and hormonal variables in healthy male subjects (2020)

Almorexant was well tolerated and had no effect on the spectrum of pharmacodynamic variables assessed. Ophthalmology and testicular findings detected in preclinical studies were not observed in this clinical study. Therefore, these preclinical findings appear not to be relevant for humans and do not prevent from conducting larger clinical trials with either healthy subjects or patients.
Blue Laser Diode Wavelength Selection With a Variable Reflectivity Resonant Mirror (2014)

A guided-mode resonance filter is designed and fabricated for externally locking a GaN blue laser diode. The external mirror design is polarization selective which allows the reflectivity to be tuned, in order to optimize the output coupling of the cavity. The resonance demonstrates a line-width <;0.5 nm, centered at 445.6 nm with an output power in excess of 0.5 W of CW power without temperature control.
Using Taint Analysis and Reinforcement Learning (TARL) to Repair Autonomous Robot Software (2020)

It is important to be able to establish formal performance bounds for autonomous systems. However, formal verification techniques require a model of the environment in which the system operates; a challenge for autonomous systems, especially those expected to operate over longer timescales. This paper describes work in progress to automate the monitor and repair of ROS-based autonomous robot software written for an a-priori partially known and possibly incorrect environment model. A taint analysis method is used to automatically extract the data-flow sequence from input topic to publish topic, and instrument that code. A unique reinforcement learning approximation of MDP utility is calculated, an empirical and non-invasive characterization of the inherent objectives of the software designers. By comparing off-line (a-priori) utility with on-line (deployed system) utility, we show, using a small but real ROS example, that it's possible to monitor a performance criterion and relate violations of the criterion to parts of the software. The software is then patched using automated software repair techniques and evaluated against the original off-line utility.