gebhart/patrepeval huggingface dataset:
Implementing structured handoffs to verify operating room blood delivery using a quality academy training program: an interrupted time-series analysis (2021)

Using the quality academy framework supported the implementation of a structured handoff during blood delivery to the OR, resulting in a significant increase in verified deliveries.
46.3: The Effect of Surface Structure on the Performance of a Ferroelectric LCD (1998)

Abstract The performance of ferroelectric liquid crysta displays are particularly sensitive to achieving the correct alignment conditions. Topographical studies of the surface layers of a colour FLCD have been made using tapping mode atomic force (AFM). The results are compared with detailed studies of test cells at different stages of device fabrication. An understanding of the relationship between the nanoscopic structure of the surfaces and the bulk alignment of the liquid crystal is developed. This enables device properties such as speed, contrast and viewing angle to be improved uniformly over the panel.
Charge Separation Mechanisms in Ordered Films of Self-Assembled Donor–Acceptor Dyad Ribbons (2017)

Orthogonal attachment of polar and nonpolar side-chains to a zinc porphyrin-perylenediimide dyad (ZnP-PDI, 1a) is shown to result in self-assembly of ordered supramolecular ribbons in which the ZnP and PDI molecules form segregated π-stacked columns. Following photoexcitation of the ordered ribbons, ZnP<sup>+•</sup>-PDI<sup>-•</sup> radical ion pairs form in <200 fs and subsequently produce a 30 ± 3% yield of free charge carriers that live for about 100 μs. Elongating the side chains on ZnP and PDI in 1b enhances the order of the films, but does not result in an increase in free charge carrier yield. In addition, this yield is independent of temperature, free energy of reaction, and the ZnP-PDI distance in the covalent dyad. These results suggest that the free charge carrier yield in this system is not limited by a bound charge transfer (CT) state or promoted by a vibronically hot CT state. Instead, it is likely that π-stacking of the segregated donors and acceptors within the ribbons results in delocalization of the charges following photoexcitation, allowing them to overcome Coulombic attraction and generate free charge carriers.
A novel technique for characterizing the surface coverage of thin-film chemical vapor deposition in ultra-high-aspect-ratio microstructures (1995)

A simple technique is introduced for accurately characterizing the surface coverage of chemical vapor deposition (CVD) processes in microstructures with very high aspect ratios. Conventional microfabrication processes are used to produce a planar array of capillary-like silicon structures with entrance dimensions as small as 2 μm and aspect ratios ranging from 10:1 to 200:1. Dielectric or semiconductor films are then deposited on the inner and outer surfaces of the capillary by low pressure chemical vapor deposition (LPCVD). After deposition, the inner surface of the capillary is exposed and the thickness of the CVD film deposited on the interior of the capillary is measured by thin-film spectrophotometry. Thickness measurements are taken along the entire length of the capillary, thus providing a deposition profile for the CVD process under investigation. Deposition profiles were measured in these structures for LPCVD silicon nitride (SiH2Cl2/NH3 precursors), polysilicon (SiH4 precursor), and silicon dioxide (tetraethoxysilane/O3 precursors). The deposition uniformity (Uc), defined as the minimum film thickness within the capillary divided by the thickness just outside the capillary entrance, ranged from nearly 0.5 for the SiO2 process to greater than 0.9 for the polysilicon process, suggesting that these CVD processes may be applied to the fabrication of devices requiring conformal thin-film deposition over high-aspect-ratio features.
Bacillus anthracis Acetyltransferases PatA1 and PatA2 Modify the Secondary Cell Wall Polysaccharide and Affect the Assembly of S-Layer Proteins (2012)

The envelope of Bacillus anthracis encompasses a proteinaceous S-layer with two S-layer proteins (Sap and EA1). Protein assembly in the envelope of B. anthracis requires S-layer homology domains (SLH) within S-layer proteins and S-layer-associated proteins (BSLs), which associate with the secondary cell wall polysaccharide (SCWP), an acetylated carbohydrate that is tethered to peptidoglycan. Here, we investigated the contributions of two putative acetyltransferases, PatA1 and PatA2, on SCWP acetylation and S-layer assembly. We show that mutations in patA1 and patA2 affect the chain lengths of B. anthracis vegetative forms and perturb the deposition of the BslO murein hydrolase at cell division septa. The patA1 and patA2 mutants are defective for the assembly of EA1 in the envelope but retain the ability of S-layer formation with Sap. SCWP isolated from the patA1 patA2 mutant lacked acetyl moieties identified in wild-type polysaccharide and failed to associate with the SLH domains of EA1. A model is discussed whereby patA1- and patA2-mediated acetylation of SCWP enables the deposition of EA1 as well as BslO near the septal region of the B. anthracis envelope.
Synthesis of the antitumor bisindole alkaloid vinblastine: diastereoselectivity and solvent effect on the stereochemistry of the crucial C-15-C-18' bond (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of the antitumor bisindole alkaloid vinblastine: diastereoselectivity and solvent effect on the stereochemistry of the crucial C-15-C-18' bondPhilip Magnus, Andrew Stamford, and Mark LadlowCite this: J. Am. Chem. Soc. 1990, 112, 22, 8210–8212Publication Date (Print):October 1, 1990Publication History Published online1 May 2002Published inissue 1 October 1990https://pubs.acs.org/doi/10.1021/ja00178a079https://doi.org/10.1021/ja00178a079research-articleACS PublicationsRequest reuse permissionsArticle Views463Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Shock Wave Interaction With Laser-Generated Single Bubbles (2006)

The interaction of lithotripter shock wave (LSW) with laser‐generated single vapor bubbles in water is investigated experimentally using high‐speed photography and pressure measurement via a fiber optic probe hydrophone. An optimal bubble size can be determined during both the expansion and collapse phase of the bubble oscillation that leads to the maximum pressure amplification, which is produced when the collapse time matches the compressive pulse duration of the LSW.
Supplementary Table 2 from Concordant Release of Glycolysis Proteins into the Plasma Preceding a Diagnosis of ER<sup>+</sup> Breast Cancer (2023)

&lt;p&gt;PDF file - 52K&lt;/p&gt;
More antibody with less antigen: Can immunogenicity of attenuated live virus vaccines be improved? (2002)

New or improved vaccines against viruses such as influenza, parainfluenza types 1-3, measles, dengue, and respiratory syncytial virus would prevent an enormous burden of morbidity and mortality. Vaccines or vaccine candidates exist against these viral diseases, but all could potentially be improved if the immunogenicity of the vaccine could be enhanced. We found that the immunogenicity in primates of a live-attenuated vaccine candidate for parainfluenza virus type 3, an enveloped RNA virus that is an important etiologic agent of pediatric respiratory tract disease, could be enhanced by expression of granulocyte-macrophage colony-stimulating factor (GM-CSF) from an extra gene inserted into the genome of a cDNA-derived virus. Expression of GM-CSF by the live attenuated recombinant virus did not per se affect the level of pulmonary viral replication in rhesus monkeys after topical administration, which was 40-fold lower than that of WT parainfluenza virus type 3. Despite that, the expressed extra gene augmented the virus-specific serum antibody response to a level that was (i) 3- to 6-fold higher than that induced by the same virus with an unrelated RNA insert of equal length and (ii) equal to the response induced by nonattenuated WT virus. In addition, topical immunization with the attenuated virus expressing GM-CSF induced a greater number of virus-specific IFN-gamma-secreting T lymphocytes in the peripheral blood of monkeys than did immunization with the control virus bearing an unrelated RNA insert. These findings show that the immunogenicity of a live-attenuated vaccine virus in primates can be enhanced without increasing the level of virus replication. Thus, it might be possible to develop live-attenuated vaccines that are as immunogenic as parental WT virus or, possibly, even more so.
A Power Efficient QoS Provisioning Architecture for Wireless Ad Hoc Networks (2006)

The work presented in this paper1 focuses on a new approach in provisioning Quality of Service (QoS) in ad hoc wireless networks, aiming at making the best use of ad hoc networking as a candidate technology for next generation wireless networks. Specifically, a cross-layer QoS provisioning architecture for wireless ad hoc networks is introduced and described, based on the integration of the recently proposed service vector concept at the network layer and a delay bounded power efficient scheduling at the data link layer. It is demonstrated through modeling and simulations that this novel architecture can provide considerable performance improvements in terms of both power savings and enhanced QoS granularity in wireless ad hoc networks. Furthermore, the performance of the proposed scheme under various traffic arrival rates and distributions is evaluated.
Neoadjuvant chemotherapy (NACT) is an effective way of managing elderly women with advanced stage ovarian cancer (FIGO Stage IIIC and IV) (2012)

NACT is associated with reduced perioperative morbidity in elderly patients with advanced stage ovarian cancer.
Copy number variations in a Brazilian cohort with autism spectrum disorders highlight the contribution of cell adhesion genes (2021)

Prediction of pathogenicity of rare copy number variations (CNVs), a genomic alteration known to contribute to the etiology of autism spectrum disorder (ASD), represents a serious limitation to interpreting genetic tests, particularly for genetic counseling purposes. Chromosomal microarray analysis (CMA) was conducted in a unique collection of 144 Brazilian individuals with ASD of strong European and African ancestries. Rare CNVs were detected in 39 patients: 41 of unknown significance (VUS), four pathogenic and one likely pathogenic CNVs (clinical yield of 4.1%; 5/122). Based on gene content and recurrence in three large cohorts [a Brazilian neurodevelopmental disorder cohort, the autism MSSNG cohort, and the Canadian-based Centre for Applied Genomics microarray database], this work strengthened the pathogenicity of 14 genes (FAT1, CAMK4, BIRC6, DPP6, CSMD1, CTNNA3, CDH8/CDH11, CDH13, OR1C1, CNTN6, CNTNAP4, FGF2 and PTPRN2) within 14 CNVs. Notably, enrichment of cell adhesion proteins to ASD etiology was identified (p < 0.05), highlighting the importance of these gene families in the etiology of ASD.
Image-height offset in TTL on-axis alignment method (1990)

The problems of the offset errors in the TTL alignment are studied. The further the position of alignment optics is from the center of the projection lens the bigger the offset error becomes. The lmageheight offset is the offset error caused by the position of alignment optics on the imaged field of projection lens. The maximum values of lmage. height offset for the dark and bright field alignment modes are O. 3p. m and O. O8tm respectively. The lmageheight offset is large with the dark field alignment because the stopper (spatial filter) in the optics is not fixed at the best place. 1 Recently the resolution of reduction projection photolithography has been improved to linewidth accuracy of 0. 5 pm. The required overlay accuracy is generally one fourth or one fifth of the pattern width thus a registration of the order of tens of nanometers is required for submicron devices fabrication. The overlay errors are divided into the intra4ield matching error and the registration error. The intra-field matching error consists of the difference in lens distortions between several steppers. If only one stepper is used to fabricate the device the overlay accuracy is almost equal to the registration accuracy. Many alignment methods have been developed in order to achieve a fine registration accuracy. Recently the g-line stepper has used two typical alignment methods. One is the TTL on axis alignment method
Biomechanical analysis of a newly designed bioabsorbable anterior cervical plate (2005)

Bioabsorbable plates provide better stability than resorbable mesh. Although the results of this study do not necessarily indicate that a resorbable plate confers equivalent stability to a metal plate, the resorbable ACP certainly yielded better results than the resorbable mesh. Bioabsorbable fusion ACPs should therefore be considered as alternatives to metal plates when a graft containment device is required.
Data from TRK Fusions Are Enriched in Cancers with Uncommon Histologies and the Absence of Canonical Driver Mutations (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;TRK inhibitors achieve marked tumor-agnostic efficacy in TRK fusion–positive cancers and consequently are now an established standard of care. Little is known, however, about the demographics, outcomes, response to alternative standard therapies, or genomic characteristics of TRK fusion–positive cancers.&lt;/p&gt;Experimental Design:&lt;p&gt;Utilizing a center-wide screening program involving more than 26,000 prospectively sequenced patients, genomic and clinical data from all cases with TRK fusions were extracted. An integrated analysis was performed of genomic, therapeutic, and phenomic outcomes.&lt;/p&gt;Results:&lt;p&gt;We identified 76 cases with confirmed TRK fusions (0.28% overall prevalence) involving 48 unique rearrangements and 17 cancer types. The presence of a TRK fusion was associated with depletion of concurrent oncogenic drivers (&lt;i&gt;P&lt;/i&gt; &lt; 0.001) and lower tumor mutation burden (&lt;i&gt;P&lt;/i&gt; &lt; 0.001), with the exception of colorectal cancer where TRK fusions cooccur with microsatellite instability (MSI-H). Longitudinal profiling in a subset of patients indicated that TRK fusions were present in all sampled timepoints in 82% (14/17) of cases. Progression-free survival on first-line therapy, excluding TRK inhibitors, administered for advanced disease was 9.6 months [95% confidence interval (CI), 4.8–13.2]. The best overall response rate achieved with chemotherapy containing–regimens across all lines of therapy was 63% (95% CI, 41–81). Among 12 patients treated with checkpoint inhibitors, a patient with MSI-H colorectal cancer had the only observed response.&lt;/p&gt;Conclusions:&lt;p&gt;TRK fusion–positive cancers can respond to alternative standards of care, although efficacy of immunotherapy in the absence of other predictive biomarkers (MSI-H) appears limited. TRK fusions are present in tumors with simple genomes lacking in concurrent drivers that may partially explain the tumor-agnostic efficacy of TRK inhibitors.&lt;/p&gt;&lt;/div&gt;
PEGylated Biopharmaceuticals (2015)

PEGylation (the covalent binding of one or more polyethylene glycol molecules to another molecule) is a technology frequently used to improve the half-life and other pharmaceutical or pharmacological properties of proteins, peptides, and aptamers. To date, 11 PEGylated biopharmaceuticals have been approved and there is indication that many more are in nonclinical or clinical development. Adverse effects seen with those in toxicology studies are mostly related to the active part of the drug molecule and not to polyethylene glycol (PEG). In 5 of the 11 approved and 10 of the 17 PEGylated biopharmaceuticals in a 2013 industry survey presented here, cellular vacuolation is histologically observed in toxicology studies in certain organs and tissues. No other effects attributed to PEG alone have been reported. Importantly, vacuolation, which occurs mainly in phagocytes, has not been linked with changes in organ function in these toxicology studies. This article was authored through collaborative efforts of industry toxicologists/nonclinical scientists to address the nonclinical safety of large PEG molecules (>10 kilo Dalton) in PEGylated biopharmaceuticals. The impact of the PEG molecule on overall nonclinical safety assessments of PEGylated biopharmaceuticals is discussed, and toxicological information from a 2013 industry survey on PEGylated biopharmaceuticals under development is summarized. Results will contribute to the database of toxicological information publicly available for PEG and PEGylated biopharmaceuticals.
Abstract 2668: Detoxification of metabolites from antibody-maytansinoid conjugates by human liver microsomes (2010)

Abstract Six antibody-maytansinoid conjugates (AMCs) consisting of the cytotoxic maytansinoid, DM1 or DM4, linked to a tumor-targeting monoclonal antibody are undergoing clinical evaluation, with the most advanced in Phase III testing. In these AMCs, the maytansinoid is attached through its C3 side chain to the antibody via a thioether or disulfide bond. The antibody moiety of the conjugate binds specifically to a tumor cell after which the conjugate is internalized and processed to release one or more maytansinoid metabolites (MMs) which kill the cell. Some of these MMs are hydrophobic and highly potent against both the forming cell and neighboring dividing cells, while others are charged or polar compounds that are highly toxic to the cell that intracellularly released them, but have a relatively low toxicity to adjacent cells due to poor membrane permeability. Similar MMs are formed from AMCs inside cells of the reticulo-endothelial system (RES), the primary route of elimination of proteinaceous therapeutics such as AMCs. We have previously reported, from studies with radiolabeled MMs in mice, that the primary elimination route of RES-formed MMs is via the liver, and entails biliary excretion of relatively low potency charged or polar maytansinoids. It would be desirable to know if MMs generated from AMCs in the RES systems of patients can be inactivated by the oxidative processes of the human liver. To model this, MMs and other maytansinoids were synthesized and then exposed in vitro to human liver microsomes. The resulting microsomal metabolites were identified by HPLC/MS and their cytotoxicities were determined. In general, the major metabolites formed from microsome exposure occurred via oxidation on the C3 side chain, with only minimal microsome-dependent alterations noted in the macrocycle. Non-charged hydrophobic maytansinoids containing at least one sulfur atom were oxidized on the sulfur atom(s) to yield one or more products which were significantly less cytotoxic than the substrate. For example, the highly cytotoxic tumor cell metabolite, S-methyl DM4, was converted to its sulfoxide and sulfone analogues, which were more than 20-fold less potent than S-methyl DM4. Charged maytansinoids containing an amino acid or a carboxylic acid were poorly metabolized by the human liver microsomes even when these maytansinoids contained one or more sulfur atoms. These data suggest that the highly potent, non-charged MMs formed in the tumor cells or the RES systems of patients would be rendered less toxic through oxidation in the liver prior to biliary elimination. Furthermore, the less potent, charged MMs likely would not be further processed by liver in a way that would increase their systemic toxicity. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2668.
Whole Genome Sequencing Defines the Genetic Heterogeneity of Familial Pancreatic Cancer (2015)

The genetic basis of disease susceptibility in the majority of patients with familial pancreatic cancer is unknown. We whole genome sequenced 638 patients with familial pancreatic cancer and demonstrate that the genetic underpinning of inherited pancreatic cancer is highly heterogeneous. This has significant implications for the management of patients with familial pancreatic cancer.
Effects of Hydrothermal Treatment on Firing Process of Silicon Nitride Containing Y<sub>2</sub>O<sub>3</sub>-Nd<sub>2</sub>O<sub>3</sub> Additive (1998)

The firing behavior of β-Si3N4 powder corroded under hydrothermal conditions was investigated by transmission electron microscopy (TEM) and energy dispersive X-ray spectroscopy (EDX). TEM and EDX analyses suggested that the hydrothermal treatment enhanced the formation of transient growth bands in β-Si3N4 ceramics containing Y2O3-Nd2O3 additive during firing at high temperature. Also, EDX analysis indicated that the grain boundary regions around the grown β-Si3N4 grains contained a Y-Nd-Si-O-N phase.
Reply: Rationale for Anticoagulant Therapy of Pulmonary Fibrosis (2014)

From the Authors:

We appreciate the insightful letter by Bogatkevich and colleagues, and strongly concur with their conclusions to carefully consider the potential unique antifibrotic effects of inhibiting individual components of the coagulation cascade, especially thrombin. Indeed, the unique effects of individual members of the coagulation cascade, compared with the cascade as a whole, deserve additional respect in light of the unsuccessful AntiCoagulant Effective in Idiopathic Pulmonary Fibrosis (ACE-IPF) trial (1, 2).

At the time of our trial development, we were charged with designing a trial using available, FDA-approved, therapeutic interventions for pathways involved in fibrosis. We believe the ACE trial does demonstrate that the coagulation cascade (or other vitamin K–dependent proteins) plays a role in IPF, in that use of warfarin did lead to worsened outcomes (2). The notion of a more selective blockade of thrombin activity is an attractive idea.

Our understanding of thrombin activity and protease-activated receptor (PAR)-mediated lung inflammation and fibrosis is growing rapidly. The authors of the letter to the editor have contributed significantly to this understanding through their findings that the thrombin inhibitor, dabigatran, has antifibrotic effects on lung fibroblasts and in a murine lung fibrosis model (3, 4). Moreover, Wygrecka and colleagues demonstrate that knockdown of PAR-1 and PAR-3 together, rather than PAR-1 alone, was necessary to inhibit thrombin-mediated epithelial to mesenchymal transition (5). The PARs remain an interesting antifibrotic target, and understanding their complex biological effects may be critical in the selection of a successful therapy. Given the availability of dabigatran etexilate, we would fully support a clinical trial to evaluate its activity. We hope that a validation of the biological effect on the correct target in vivo, would be a key part of any such clinical outcome trial in IPF, so that we can further advance this promising field.