gebhart/patrepeval huggingface dataset:
Programmable logic circuits for functional integrated smart plastic systems (2014)

In this paper, we present a functional integrated plastic system. We have fabricated arrays of organic thin-film transistors (OTFTs) and printed electronic components driving an electrophoretic ink display up to 70 mm by 70 mm on a single flexible transparent plastic foil. Transistor arrays were quickly and reliably configured for different logic functions by an additional process step of inkjet printing conductive silver wires and poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) resistors between transistors or between logic blocks. Among the circuit functions and features demonstrated on the arrays are a 7-stage ring oscillator, a D-type flip-flop memory element, a 2:4 demultiplexer, a programmable array logic device (PAL), and printed wires and resistors. Touch input sensors were also printed, thus only external batteries were required for a complete electronic subsystem. The PAL featured 8 inputs, 8 outputs, 32 product terms, and had 1260 p-type polymer transistors in a 3-metal process using diode-load logic. To the best of our knowledge, this is the first time that a PAL concept with organic transistors has been demonstrated, and also the first time that organic transistors have been used as the control logic for a flexible display which have both been integrated on to a single plastic substrate. The versatility afforded by the additive inkjet printing process is well suited to organic programmable logic on plastic substrates, in effect, making flexible organic electronics more flexible.
Ultra-sensitive AAV capsid detection by immunocapture-based qPCR following factor VIII gene transfer (2021)

Adeno-associated virus (AAV)-based gene therapy vectors are replication-incompetent and thus pose minimal risk for horizontal transmission or release into the environment. In studies with AAV5-FVIII-SQ (valoctocogene roxaparvovec), an investigational gene therapy for hemophilia A, residual vector DNA was detectable in blood, secreta, and excreta, but it remained unclear how long structurally intact AAV5 vector capsids were present. Since a comprehensive assessment of vector shedding is required by regulatory agencies, we developed a new method (termed iqPCR) that utilizes capsid-directed immunocapture followed by qPCR amplification of encapsidated DNA. The limit of detection for AAV5 vector capsids was 1.17E+04 and 2.33E+04 vg/mL in plasma and semen, respectively. Acceptable precision, accuracy, selectivity, and specificity were verified; up to 1.00E+09 vg/mL non-encapsidated vector DNA showed no interference. Anti-AAV5 antibody plasma concentrations above 141 ng/mL decreased AAV5 capsid quantification, suggesting that iqPCR mainly detects free capsids and not those complexed with antibodies. In a clinical study, AAV5-FVIII-SQ capsids were found in plasma and semen but became undetectable within nine weeks after dose administration. Hence, iqPCR monitors the presence and shedding kinetics of intact vector capsids following AAV gene therapy and informs the potential risk for horizontal transmission.
Sparsity regularized Principal Component Pursuit (2017)

We study the problem of low-rank and sparse decomposition from possibly noisy observations. We propose a novel objective function with nuclear norm on the low-rank term and ℓ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> -`norm' on the sparse term, as well as ℓ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> -norm on the additive noise term. When there is no dense inlier noise, the proposed method shares the same theoretical guarantee as the Principal Component Pursuit (PCP), i.e., it can recover the low-rank component and sparse component exactly with high probability. Simulations in the noisy case demonstrate that the proposed method outperforms existing state-of-the-art methods. Results on a surveillance video application further verify the effectiveness of the proposed method.
SUPPRESSION OF POSTOVULATORY GONADOTROPIN LEVELS DOES NOT AFFECT CORPUS LUTEUM FUNCTION IN RHESUS MONKEYS (1983)

The exact mechanism(s) of control of corpus luteum function remains unknown. To address the question whether luteinizing hormone (LH) plays an important role, the following experiments were performed in cycling rhesus monkeys. Experiment 1: 10 monkeys were followed for 2 consecutive cycles and ovulation data determined using serum estradiol (E2) measurements and serial laparoscopies. In the second cycle, starting on day 1 after ovulation, the animals received daily administration of a potent inhibitory LHRH analog, [N-Ac-D-Trp1,3,D-p-Cl-Phe1,D-Phe6,D-Ala10]-LH-RH (N = 5) or vehicle (N = 5) until the onset of vaginal bleeding. Serum FSH and LH concentrations declined significantly in animals treated with the antagonist. However, E2 and progesterone (P) levels were not different from vehicle-treated monkeys. Luteal phase length in both groups was unchanged from the control cycle. Experiment 2: the same protocol was followed, adding the administration of hCG in increasing dosages from days 6-10 after ovulation (Day 6 = 30 IU, Day 7 = 60 IU, Day 8 = 90 IU, Day 9 = 180 IU, Day 10 = 360 IU). The increase in serum P concentration was the same for both groups. These results suggest that significant suppression on gonadotropin levels after ovulation does not affect corpus luteum function and that the inhibitory analog does not have a direct effect on the ovary.
A tight characterization of NP with 3 query PCPs (1998)

It is known that there exists a PCP characterization of NP where the verifier makes 3 queries and has a one-sided error that is bounded away from 1; and also that 2 queries do not suffice for such a characterization. Thus PCPs with 3 queries possess non-trivial verification power and motivate the task of determining the lowest error that can be achieved with a 3-query PCP. Recently, Hastad [10] has shown a tight characterization of NP by constructing a 3-query PCP verifier with &amp;quot;error&amp;quot; arbitrarily close to 1=2. Unfortunately, this verifier makes two-sided error and Hastad makes essential use of this feature. One-sided error, on the other hand, is a natural notion to associate with a proof system, since it has the desirable property that every rejected proof has a short counterexample. The question of determining the smallest error for which there exists a 3-query PCP verifier making one-sided error and accepting an NP-complete language, however, remained open. We resolve this question...
Fault detection in seismic volumes using a 2.5D residual neural networks approach (2021)

Fault identification is an essential but tedious task for interpreters working on reservoir characterization. Due to their 3D nature and their number within seismic volumes, many tend to be left un-interpreted. In such situations, automation of the process can save costs and time. Here we propose a form for a 2.5D residual neural network designed to detect faults in seismic volumes and examine its robustness and expense through tests on synthetic data.
Assessing The Impact Of Continuing Engineering Education (2020)

Abstract NOTE: The first page of text has been automatically extracted and included below in lieu of an abstract 1 _-— . .- . . S e s s i o n 2230 ‘ .— ASSESSING THE IMPACT OF CONTINUING ENGINEERING EDUCATION Meg Karakekes, Susan Anderson, Jim Moharam, Ray Chen The University of Texas at Austin/SPIE/University of Central Florida/The University of Texas at Austin I. INTRODUCTION Continuing education is critical for engineers and the organizations that employ them (Gomes, Houche- Mong, Houche-Mong and Wakelin, 199 1; Wolff, 1993). However, findings on the impact of continuing engineering education are mixed. Social Research Inc. (1969)4 examined characteristics of engineers laid off by a major corporation. The common denominator was that none had taken part in continuing education during the preceding six years. Klus and Jones (1975)4 found a direct statistical relationship between individual engineers’ salaries and their participation in continuing education. Dalton and Thompson (1971) however, found no relationship between performance ratings of engineers and participation in continuing education. The limited research on the impact of continuing education contributes to the confusion. ._Current trends in continuing education are encouraging more attention to this area of inquiry. Potential participants and sponsoring employers are asking for proof of value for their time and monetary investment. The National Alliance for Photonics Education in Manufacturing’s (NAPEM) mission is to enhance the national training effort by providing regionally-based educational programs focused on applying photonics to commercial applications. Only by assessing the impact of its educational programs can NAPEM determine if and how its continuing education offerings enable engineers to be more effective. Table 1 identifies NAPEM members. Table 1: Alliance Members and Manufacturing Areas Served Alliance Members Manufacturing Area -. University of Central Florida Dual-use & End-to-end System Testing Industrial Technology Institute (Michigan) Optical Metrology and Durable Goods University of Connecticut Laser Materials Processing The University of Texas at Austin Semiconductor The International Society for Optical Engineering (SPIE) (NAPEM is partially funded through a federal Technology Reinvestment Project grant.) Additionally, each regional program recruits a Curriculum Advisory Board. NAPEM unites the strengths of a professional society, educators, engineering managers, engineers, and human resource personnel in designing, implementing, and evaluating experimental continuing education programs. This paper focuses on assessing the impact of NAPEM’s regional pilot programs for the semiconductor, and dual-use and end-to-end systems testing industries. (These programs piloted before the other regional NAPEM.) ~’tixi$! 1996 ASEE Annual Conference Proceedings ‘.
The Role of Angiotensin II AT1 Receptor in the Maintenance of Hemodynamics in a Canine Model of Coronary Microembolization-Induced Heart Failure (1999)

The purpose of this study was to determine whether Angiotensin II (Ang II) contributes to the regulation of resting hemodynamics via Ang II type 1 (AT1) receptors in awake dogs with coronary microembolization-induced heart failure. Six dogs were surgically instrumented for measurement of systemic hemodynamics and for coronary microembolization. The acute hemodynamic effects of a selective AT1-receptor antagonist, GR138950 (1 mg/kg, i.v.), were determined before and after congestive heart failure (CHF). GR138950 had no effects on hemodynamics before CHF Daily coronary microembolizations (through the previously implanted coronary catheter) resulted in CHF, as documented by hemodynamic measurements, a slight but significant increased Ang II plasma level (17.4 +/- 1.6 vs. 23 +/- 1.0 pg/ml; p < 0.05), and characteristic clinical signs of CHF. After CHF, GR138950 significantly increased left ventricular dP/dt(max) (LVdP/dt(max)) from 1,754 +/- 68 to 2,347 +/- 114 mm Hg/s and decreased LV systolic pressure (LVSP) from 118 +/- 5 to 101 +/- 7 mm Hg; meanwhile, heart rate (from 132 +/- 4 to 102 +/- 6 beats/min) and LV end-diastolic pressure (LVEDP; from 17 +/- 3 to 9 +/- 1.5 mm Hg) were significantly decreased. Mean arterial pressure (MAP) was not affected. The peak effects occurred 90 min after administration. Thus Ang II contributes significantly to resting hemodynamics via AT1 receptors in this CHF model; that is, the specific AT1 blocker inhibits the negative inotropic actions of Ang II in the CHF state.
A Review On Zno-Based Electrical Biosensors for Cardiac Biomarker Detection (2017)

Over the past few decades zinc oxide (ZnO)-based thin films and nanostructures have shown unprecedented performance in a wide range of applications. In particular, owing to high isoelectric point, biocompatibility and other multifunctional characteristics, ZnO has extensively been studied as a transduction material for biosensor development. The fascinating properties of ZnO help retain biological activity of the immobilized biomolecule and help in achieving enhanced sensing performance. As a consequence of recent advancements in this multidisciplinary field, diagnostic biosensors are expanding beyond traditional clinical labs to point-of-care and home settings. Label-free electrical detection of biomarkers has been demonstrated using ZnO-sensing platforms. In this review we highlight the characteristics of ZnO that enable realization of its use in development of point-of-care biosensors toward disease diagnosis, in particular cardiovascular diseases.
Improvement of light quality by DBR structure in white LED (2014)

This study demonstrates the application of DBR structure into the remote phosphor structure to improve the angular correlated color temperature (CCT) deviation in white light-emitting diodes (WLEDs). In the experiment, the LED device with DBR structure yielded a higher luminous efficiency than a conventional structure. The CCT deviation can be improved from 1758K to 280K in a range of -70 to 70 degree and the luminous flux increases more than 10% due to the enhancement of the light extraction of the blue light. Moreover, the reflectance of the different DBR structures is analyzed with different angles to reveal the reasons of such improvements. As the result, this LED device with DBR structure shows the great potential to use as the next generation lighting source.
ChemInform Abstract: The Chemistry of Pentavalent Organobismuth Reagents. Part 7. The Possible Role of Radical Mechanisms in the Phenylation Process for Bismuth(V), and Related Lead(IV), Iodine(III), and Antimony(V) Reagents. (1987)

Abstract The phenylation of the ketone (VII) with the Bi reagent (Ia) in the presence of the base (VIII) yields (IX) which is likewise obtained when nitrosobenzene (X) is added as a radical trapping agent to the reaction mixture.
In vivo iron quantification in collagenase‐induced microbleeds in rat brain (2011)

Brain microbleeds (BMB) are associated with chronic and acute cerebrovascular disease. Because BMB present in the brain is a source of potentially cytotoxic iron proportional to the volume of extravasated blood, BMB iron content is a potentially valuable biomarker both to assess tissue risk and small cerebral vessel health. We recently reported methods to quantify focal iron sources using phase images that were tested in phantoms and BMB in postmortem tissue. In this study, we applied our methods to small hemorrhagic lesions induced in the in vivo rat brain using bacterial collagenase. As expected by theory, measurements of geometric features in phase images correlated with lesion iron content measured by graphite furnace atomic absorption spectrometry. Iron content estimation following BMB in an in vivo rodent model could shed light on the role and temporal evolution of iron-mediated tissue damage and efficacy of potential treatments in cerebrovascular diseases associated with BMB.
Special Issue on Polarization (2007)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTSpecial Issue on PolarizationWilliam L. JorgensenView Author Information Editor-in-Chief, JCTC, Yale UniversityCite this: J. Chem. Theory Comput. 2007, 3, 6, 1877Publication Date (Web):November 13, 2007Publication History Published online13 November 2007Published inissue 1 November 2007https://pubs.acs.org/doi/10.1021/ct700252ghttps://doi.org/10.1021/ct700252geditorialACS PublicationsCopyright © 2007 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views2103Altmetric-Citations112LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (12 KB) Get e-AlertscloseSUBJECTS:Ions,Molecular interactions,Molecular mechanics,Polarization,Solution chemistry Get e-Alerts
Hereditary sideroblastic anemia and glucose-6-phosphate dehydrogenase deficiency in a negro family (1968)

Detailed clinical and genetic studies have been performed in a Negro family, which segregated for sex-linked sideroblastic anemia and glucose-6-phosphate dehydrogenase (G-6-DP) deficiency. This is the first such pedigree reported. Males affected with sideroblastic anemia had growth retardation, hypochromic microcytic anemia, elevated serum iron, decreased unsaturated iron-binding capacity, increased (59)Fe clearance, low (59)Fe incorporation into erythrocytes, normal erythrocyte survival ((51)Cr), normal hemoglobin electrophoretic pattern, erythroblastic hyperplasia of marrow with increased iron, and marked increase in marrow sideroblasts, particularly ringed sideroblasts. Perinuclear deposition of ferric aggregates was demonstrated to be intramitochondrial by electron microscopy. Female carriers of the sideroblastic gene were normal but exhibited a dimorphic population of erythrocytes including normocytic and microcytic cells. The bone marrow studies in the female (mother) showed ringed marrow sideroblasts. Studies of G-6-PD involved the methemoglobin elution test for G-6-PD activity of individual erythrocytes, quantitative G-6-PD assay, and electrophoresis. In the pedigree, linkage information was obtained from a doubly heterozygous woman, four of her sons, and five of her daughters. Three sons were doubly affected, and one was normal. One daughter appeared to be a recombinant. The genes appeared to be linked in the coupling phase in the mother. The maximum likelihood estimate of the recombination value was 0.14. By means of Price-Jones curves, the microcytic red cells in peripheral blood were quantitated in female carriers. The sideroblast count in the bone marrow in the mother corresponded closely to the percentage of microcytic cells in peripheral blood. This is the second example in which the cellular expression of a sex-linked trait has been documented in the human red cells, the first one being G-6-PD deficiency. The coexistence of the two genes in doubly heterozygous females has made it possible to study correlations in cell counts; our studies showed a strong positive correlation except in the probable recombinant in which a reciprocal relation held which indicated that X-inactivation was at least regional, rather than locus by locus.
Linking Individual Differences in Personalized Functional Network Topography to Psychopathology in Youth (2021)

ABSTRACT The spatial layout of large-scale functional brain networks differs between individuals and is particularly variable in association cortex that has been implicated in a broad range of psychiatric disorders. However, it remains unknown whether this variation in functional topography is related to major dimensions of psychopathology in youth. Capitalizing on a large sample with 27-minutes of high-quality functional MRI data (n=790, ages 8-23 years) and advances in machine learning, we examined associations between functional topography and four correlated dimensions of psychopathology (fear, psychosis, externalizing, anxious-misery) as well as an overall psychopathology factor. We found that functional topography significantly predicted individual differences in dimensions of psychopathology, driven mainly by robust associations between topography and overall psychopathology. Reduced cortical representations of association networks were among the most important features of the model. Our results emphasize the value of considering systematic differences in functional neuroanatomy for personalized diagnostics and therapeutics in psychiatry.
The effect of microwave irradiation on DNA hybridization (2009)

The effect of microwave irradiation on DNA/DNA hybridization has been studied under controlled power and temperature conditions. It was discovered that microwave irradiation led to the melting of double-stranded deoxyoligonucleotides well below their thermal melting temperature and independent of the length of the deoxyoligonucleotides. These observations indicate a specific interaction of microwaves with DNA, and have important implications in the chemical or enzymatic processing of DNA under microwave heating.
Improved Frequency Response in a SiGe npn Device through Improved Dopant Activation (2013)

We study the impact of improved dopant activation in a BiCMOS SiGe technology, using laser annealing to improve activation, and a low temperature contact module to avoid de-activation. We present the results of simple DC test structure measurements and high frequency bipolar transistor measurements. Improved activation significantly reduces sheet resistance, particularly for polysilicon layers. Likewise, reductions in the bipolar device resistance parasitics cause an improvement in maximum power gain frequency (fMAX).
A Self-Adaptive and PVT Insensitive Clock Distribution Network Design for High-Speed Memory Interfaces (2009)

A clock distribution network (CDN) insensitive to process, voltage, and temperature (PVT) variations is presented in this paper. Unlike a traditional source-synchronous interface, the CDN uses a current-mode logic (CML) divider and sense- amp-based data receiver for data capture and deserialization. The proposed input path extends its operating range beyond 4- Gb/s/pin without the need for retraining. A unique self-adaptive bias generator based on a Bandgap reference is also disclosed. Simulation data based on the CDN shows a 40% reduction in timing sensitivity for a 100 mV supply voltage change and an 85degC temperature change at 4-Gb/s using a 3-metal, 50-nm DRAM process. Design considerations are also addressed based on power, performance, and complexity.
Mixing and Chemical Kinetics Interactions in a Mach 2 Reacting Flow (1995)

An experimental study of transverse hydrogen injection and combustion behind a rearward-facing step into a Mach 2 airflow was conducted in an electrically heated (not vitiated), continuous-flow facility to evaluate the effects of initial conditions (temperature, pressure, and equivalence ratio), and analyze the interactions between mixing and combustion in supersonic, reacting flows. Neither mixing nor reaction rates dominate in this particular regime, thus the use of initial conditions to scale fuel mixing (i.e., dynamic pressure ratio) has to be modified by a descriptor that includes the effects of combustion on the flow conditions at the fuel injection station. Combustor inlet static pressure was varied from 0.25 to 0.5 atm, and total temperature from 300 to 850 K. Injector configurations include both single and staged injection with injectors of 1 and 1.5 mm diam, transverse to the airflow, behind a 5-mm rearward-facing step. Images of visible flame emission distribution at several temperatures correlated with pressure and temperature measurements are used to describe the coupling between fluid dynamics and chemical kinetics, discussed in terms of a characteristic global Damkohler number (ratio of chemical reaction rate to turbulent mixing rate). A proposed modification to mixing scaling with dynamic pressure ratio in the presence of heat release effects is presented.