gebhart/patrepeval huggingface dataset:
The importance of viscoelastic waveform inversion in VSP: Synthetic studies (2022)

The attenuation factor (Q) is essential in waveform inversion. This paper presents systematic and quantitative studies of Q on seismic waveforms of different frequencies in waveform inversion. The elastic waveform inversion (without Q update) of data with different Q values results in a slower inverted P-wave velocity and an amplitude decay that cannot match the data. We discuss the importance of the simultaneous viscoelastic inversion of velocity and attenuation.
ChemInform Abstract: Continuous Flow Photocatalysis Enhanced Using an Aluminum Mirror: Rapid and Selective Synthesis of 2′‐Deoxy and 2′,3′‐Dideoxynucleosides. (2012)

Abstract A photochemical flow reactor is developed and applied for a photoinduced electron‐transfer deoxygenation of protected nucleosides (I) and (IV).
Convolutional Phase Retrieval via Gradient Descent (2019)

We study the convolutional phase retrieval problem, of recovering an unknown signal x ∈ C <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">n</sup> from m measurements consisting of the magnitude of its cyclic convolution with a given kernel a ∈ C <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m</sup> . This model is motivated by applications such as channel estimation, optics, and underwater acoustic communication, where the signal of interest is acted on by a given channel/filter, and phase information is difficult or impossible to acquire. We show that when a is random and the number of observations m is sufficiently large, with high probability x can be efficiently recovered up to a global phase shift using a combination of spectral initialization and generalized gradient descent. The main challenge is coping with dependencies in the measurement operator. We overcome this challenge by using ideas from decoupling theory, suprema of chaos processes and the restricted isometry property of random circulant matrices, and recent analysis of alternating minimization methods.
pH‐dependence of single‐protein adsorption and diffusion at a liquid chromatographic interface (2015)

pH is a common mobile phase variable used to control protein separations due to the tunable nature of amino acid and adsorbent charge. Like other column variables such as column density and ligand loading density, pH is usually optimized empirically. Single-molecule spectroscopy extracts molecular-scale data to provide a framework for mechanistic optimization of pH. The adsorption and diffusion of a model globular protein, α-lactalbumin, was studied by single-molecule microscopy at a silica-aqueous interface analogous to aqueous normal phase and hydrophilic interaction chromatography and capillary electrophoresis interfaces at varied pH. Electrostatic repulsion resulting in free diffusion was observed at pH above the isoelectric point of the protein. In contrast, at low pH strong adsorption and surface diffusion with either no (D ∼ 0.01 μm(2) /s) or translational (D ∼ 0.3 μm(2) /s) motion was observed where the protein likely interacted with the surface through electrostatic, hydrophobic, and hydrogen bonding forces. The fraction of proteins immobilized could be increased by lowering the pH. These results show that retention of proteins at the silica interface cannot be viewed solely as an adsorption/desorption process and that the type of surface diffusion, which ultimately leads to ensemble chromatographic separations, can be controlled by tuning long-range electrostatic and short-range hydrophobic and hydrogen bonding forces with pH.
RETINAL DETACHMENT IN A PATIENT WITH LEBER CONGENITAL AMAUROSIS (2012)

Leber congenital amaurosis is a rare inherited retinal disease that can be complicated by tractional retinal detachment. Vitrectomy surgery can be used successfully to repair retinal detachments in this patient population. The patient had subsequent improvement in visual acuity and anatomical reattachment.
Non‐localizing Parathyroid Adenomas: Radiologic Error or True Entity (2013)

Objectives: Investigate radiographic assessment of non‐localizing parathyroid adenomas (NLPA). Our goal was to determine whether non‐localization is a result of radiologic interpretive error, or truly representative of non‐visible parathyroid adenoma. Methods: We performed a retrospective chart review of 364 patients who underwent parathyroidectomy over a 5‐year period. Thirty patients who were identified as having NLPA on pre‐operative imaging were included. All available patient images were re‐reviewed by two senior radiologists. Both readers were blinded to surgical outcomes and adenoma location on the first read of the imaging studies. Surgical outcomes were then revealed and the imaging was re‐reviewed. The two reader's results were subsequently compared for inter‐reader reliability using Cohen's kappa test. Results: All 30 patients with NLPA had pre‐operative 99mTc sestamibi imaging available and 18 also had an ultrasound performed. Adenomas were identified intra‐operatively and removed in all cases. Twenty‐nine of the thirty (97%) 99mTc sestamibi studies were scored by the two readers as either negative or equivocal. There was excellent inter‐observer agreement between the readers, with a kappa value of 0.706. For the ultrasound studies, however, the two readers’ inter‐observer agreement was only fair, with a kappa value of 0.351. Conclusions: The inter‐reader agreement in our series supports the conclusion that, for a sub‐population of patients with parathyroid adenoma, pre‐operative imaging will be truly negative/non‐localizing.
SAR-Based Optimization of a 4-Quinoline Carboxylic Acid Analogue with Potent Antiviral Activity (2013)

It is established that drugs targeting viral proteins are at risk of generating resistant strains. However, drugs targeting host factors can potentially avoid this problem. Herein we report structure-activity relationship studies leading to the discovery of a very potent lead compound 6-fluoro-2-(5-isopropyl-2-methyl-4-phenoxyphenyl)quinoline-4-carboxylic acid (<b>C44</b>) that inhibits human dihydroorotate dehydrogenase (DHODH) with an IC<sub>50</sub> of 1 nM, and viral replication of VSV and WSN-Influenza with an EC<sub>50</sub> of 2 nM and 41 nM. We also solved the X-ray structure of human DHODH bound to <b>C44</b>, providing structural insight into the potent inhibition of biaryl ether analogs of brequinar.
A chloroplast retrograde signal, 3’-phosphoadenosine 5’-phosphate, acts as a secondary messenger in abscisic acid signaling in stomatal closure and germination (2017)

Organelle-nuclear retrograde signaling regulates gene expression, but its roles in specialized cells and integration with hormonal signaling remain enigmatic. Here we show that the SAL1-PAP (3'-phosphoadenosine 5'- phosphate) retrograde pathway interacts with abscisic acid (ABA) signaling to regulate stomatal closure and seed germination in <i>Arabidopsis</i>. Genetically or exogenously manipulating PAP bypasses the canonical signaling components ABA Insensitive 1 (ABI1) and Open Stomata 1 (OST1); priming an alternative pathway that restores ABA-responsive gene expression, ROS bursts, ion channel function, stomatal closure and drought tolerance in <i>ost1</i>-2. PAP also inhibits wild type and <i>abi1</i>-1 seed germination by enhancing ABA sensitivity. PAP-XRN signaling interacts with ABA, ROS and Ca<sup>2+</sup>; up-regulating multiple ABA signaling components, including lowly-expressed Calcium Dependent Protein Kinases (CDPKs) capable of activating the anion channel SLAC1. Thus, PAP exhibits many secondary messenger attributes and exemplifies how retrograde signals can have broader roles in hormone signaling, allowing chloroplasts to fine-tune physiological responses.
Symmetric Brace Algebras (2003)

We develop a symmetric analog of brace algebras and discuss the relation of such algebras to $L_{\infty}$-algebras. We give an alternate proof that the category of symmetric brace algebras is isomorphic to the category of pre-Lie algebras. As an application, symmetric braces are used to describe transfers of strongly homotopy structures. We then explain how these symmetric brace algebras may be used to examine the $L_{\infty}$-algebras that result from a particular gauge theory for massless particles of high spin.
Combined 18F-Fluoride and 18F-FDG PET/CT Scanning for Evaluation of Malignancy: Results of an International Multicenter Trial (2012)

This trial demonstrated that combined (18)F(-)/(18)F-FDG PET/CT shows promising results when compared with separate (18)F(-) PET/CT and (18)F-FDG PET/CT for evaluation of cancer patients. This result opens the possibility for improved patient care and reduction in health-care costs, as will be further evaluated in future trials.
Long‐term functional correction of cystathionine β‐synthase deficiency in mice by adeno‐associated viral gene therapy (2021)

Cystathionine β-synthase (CBS) deficiency is a recessive inborn error of sulfur metabolism characterized by elevated blood levels of total homocysteine (tHcy). Patients diagnosed with CBS deficiency are currently treated by a combination of vitamin supplementation and restriction of foods containing the homocysteine precursor methionine, but the effectiveness of this therapy is limited due to poor compliance. A mouse model for CBS deficiency (Tg-I278T Cbs<sup>-/-</sup> ) was used to evaluate a potential gene therapy approach to treat CBS deficiency utilizing an AAVrh.10-based vector containing the human CBS cDNA downstream of the constitutive, strong CAG promoter (AAVrh.10hCBS). Mice were administered a single dose of virus and followed for up to 1 year. The data demonstrated a dose-dependent increase in liver CBS activity and a dose-dependent decrease in serum tHcy. Liver CBS enzyme activity at 1 year was similar to Cbs<sup>+/-</sup> control mice. Mice given the highest dose (5.6 × 10<sup>11</sup> genomes/mouse) had mean serum tHcy decrease of 97% 1 week after injection and an 81% reduction 1 year after injection. Treated mice had either full- or substantial correction of alopecia, bone loss, and fat mass phenotypes associated with Cbs deficiency in mice. Our findings show that AAVrh.10-based gene therapy is highly effective in treating CBS deficiency in mice and supports additional pre-clinical testing for eventual use human trials.
Maupéou, René Nicolas Charles Augustin de (2003)

info:eu-repo/semantics/published
Analysis of the pathogenic potential of nosocomial Pseudomonas putida strains (2015)

Pseudomonas putida strains are ubiquitous in soil and water but have also been reported as opportunistic human pathogens capable of causing nosocomial infections. In this study we describe the multilocus sequence typing of four P. putida strains (HB13667, HB8234, HB4184, and HB3267) isolated from in-patients at the Besançon Hospital (France). The four isolates (in particular HB3267) were resistant to a number of antibiotics. The pathogenicity and virulence potential of the strains was tested ex vivo and in vivo using different biological models: human tissue culture, mammalian tissues, and insect larvae. Our results showed a significant variability in the ability of the four strains to damage the host; HB13667 did not exhibit any pathogenic traits, HB4184 caused damage only ex vivo in human tissue cultures, and HB8234 had a deleterious effect in tissue culture and in vivo on rat skin, but not in insect larvae. Interestingly, strain HB3267 caused damage in all the model systems studied. The putative evolution of these strains in medical environments is discussed.
Proximal Tubules Have the Capacity to Regulate Uptake of Albumin (2015)

Evidence from multiple studies supports the concept that both glomerular filtration and proximal tubule (PT) reclamation affect urinary albumin excretion rate. To better understand these roles of glomerular filtration and PT uptake, we investigated these processes in two distinct animal models. In a rat model of acute exogenous albumin overload, we quantified glomerular sieving coefficients (GSC) and PT uptake of Texas Red-labeled rat serum albumin using two-photon intravital microscopy. No change in GSC was observed, but a significant decrease in PT albumin uptake was quantified. In a second model, loss of endogenous albumin was induced in rats by podocyte-specific transgenic expression of diphtheria toxin receptor. In these albumin-deficient rats, exposure to diphtheria toxin induced an increase in albumin GSC and albumin filtration, resulting in increased exposure of the PTs to endogenous albumin. In this case, PT albumin reabsorption was markedly increased. Analysis of known albumin receptors and assessment of cortical protein expression in the albumin overload model, conducted to identify potential proteins and pathways affected by acute protein overload, revealed changes in the expression levels of calreticulin, disabled homolog 2, NRF2, angiopoietin-2, and proteins involved in ATP synthesis. Taken together, these results suggest that a regulated PT cell albumin uptake system can respond rapidly to different physiologic conditions to minimize alterations in serum albumin level.
Technology, Business and Policy (2016)

This chapter describes parameters of importance to each of the technology-business-policy (TBP) elements with respect to broadband telecommunications. It introduces a number of technology, business and policy issues of concern to management of broadband telecommunications, and demonstrates how these issues are mapped to the ecosystem. The chapter explains value analysis, and value chains and value hierarchy. It also describes the analysis of broadband telecommunications businesses using economic models such as cost-benefit analysis. Each of the three viewpoints of the TBP framework can be individually analysed and compared based on a number of numerical and qualitative measures. The chapter presents a brief analysis of IPMobile. The TBP framework and its associated models are fundamental to the analysis and management of broadband telecommunications services and content businesses.
Engineering single photon emitters by ion implantation in diamond (2009)

Diamond provides unique technological platform for quantum technologies including quantum computing and communication. Controlled fabrication of optically active defects is a key element for such quantum toolkit. Here we report the production of single color centers emitting in the blue spectral region by high energy implantation of carbon ions. We demonstrate that single implanted defects show sub-poissonian statistics of the emitted photons and can be explored as single photon source in quantum cryptography. Strong zero phonon line at 470.5 nm allows unambiguous identification of this defect as interstitial-related TR12 color center.
Optical and SCF-X.alpha.-SW investigations of M(.pi.-C2H4), where M = copper, silver, and gold (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOptical and SCF-X.alpha.-SW investigations of M(.pi.-C2H4), where M = copper, silver, and goldDouglas F. McIntosh, Geoffrey A. Ozin, and Richard P. MessmerCite this: Inorg. Chem. 1980, 19, 11, 3321–3327Publication Date (Print):November 1, 1980Publication History Published online1 May 2002Published inissue 1 November 1980https://pubs.acs.org/doi/10.1021/ic50213a023https://doi.org/10.1021/ic50213a023research-articleACS PublicationsRequest reuse permissionsArticle Views64Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Adaptive Pulse Width Control for Precise Positioning Under the Influence of Stiction and Coulomb Friction (1988)

Conventional linear digital control fails to provide precise positioning of a control object under the influence of static friction, Coulomb friction, and backlash. This paper presents an adaptive pulse width control (PWC) scheme for a precise point-to-point positioning system. This scheme is developed based on the relationship between the displacement of a control object due to a single pulse input and the pulse width. The coefficient appearing in this relationship is estimated by a parameter adaptation algorithm. Sufficient conditions for asymptotic stability of this adaptive scheme are developed using Popov hyperstability theorem. This adaptive PWC is tested on a laboratory positioning table and is shown to be effective.
Pulmonary Artery Catheter‐Associated Thrombosis (1992)

Transesophageal echocardiography has become increasingly important in the assessment of critically ill patients. We report a 39‐year‐old patient who was incidentally noted to have a large right intraatrial thrombus associated with an indwelling pulmonary artery catheter identified by transesophageal echocardiography. This led to eventual catheter removal by open venotomy. Careful examination of intravascular devices during transesophageal echocardiography may lead to early diagnosis of catheter‐associated thrombosis and thus alter management appropriately.
Alveolar Macrophages Infected with Ames or Sterne Strain of Bacillus anthracis Elicit Differential Molecular Expression Patterns (2014)

Alveolar macrophages (AMs) phagocytose Bacillus anthracis following inhalation and induce the production of pro-inflammatory cytokines and chemokines to mediate the activation of innate immunity. Ames, the virulent strain of B. anthracis, contains two plasmids that encode the antiphagocytic poly-γ-d-glutamic acid capsule and the lethal toxin. The attenuated Sterne strain of B. anthracis, which lacks the plasmid encoding capsule, is widely adapted as a vaccine strain. Although differences in the outcome of infection with the two strains may have originated from the presence or absence of an anti-phagocytic capsule, the disease pathogenesis following infection will be manifested via the host responses, which is not well understood. To gain understanding of the host responses at cellular level, a microarray analysis was performed using primary rhesus macaque AMs infected with either Ames or Sterne spores. Notably, 528 human orthologs were identified to be differentially expressed in AMs infected with either strain of the B. anthracis. Meta-analyses revealed genes differentially expressed in response to B. anthracis infection were also induced upon infections with multiple pathogens such as Francisella Novicida or Staphylococcus aureus. This suggests the existence of a common molecular signature in response to pathogen infections. Importantly, the microarray and protein expression data for certain cytokines, chemokines and host factors provide further insights on how cellular processes such as innate immune sensing pathways, anti-apoptosis versus apoptosis may be differentially modulated in response to the virulent or vaccine strain of B. anthracis. The reported differences may account for the marked difference in pathogenicity between these two strains.
Stereochemistry of Phellinsin A: A Concise Synthesis of α‐Arylidene‐γ‐Lactones. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Effect of the Drying Process on the Intensification of Phenolic Compounds Recovery from Grape Pomace Using Accelerated Solvent Extraction (2014)

In light of their environmental and economic interests, food byproducts have been increasingly exploited and valorized for their richness in dietary fibers and antioxidants. Phenolic compounds are antioxidant bioactive molecules highly present in grape byproducts. Herein, the accelerated solvent extraction (ASE) of phenolic compounds from wet and dried grape pomace, at 45 °C, was conducted and the highest phenolic compounds yield (PCY) for wet (16.2 g GAE/100 g DM) and dry (7.28 g GAE/100 g DM) grape pomace extracts were obtained with 70% ethanol/water solvent at 140 °C. The PCY obtained from wet pomace was up to two times better compared to the dry byproduct and up to 15 times better compared to the same food matrices treated with conventional methods. With regard to Resveratrol, the corresponding dry pomace extract had a better free radical scavenging activity (49.12%) than the wet extract (39.8%). The drying pretreatment process seems to ameliorate the antiradical activity, especially when the extraction by ASE is performed at temperatures above 100 °C. HPLC-DAD analysis showed that the diversity of the flavonoid and the non-flavonoid compounds found in the extracts was seriously affected by the extraction temperature and the pretreatment of the raw material. This diversity seems to play a key role in the scavenging activity demonstrated by the extracts. Our results emphasize on ASE usage as a promising method for the preparation of highly concentrated and bioactive phenolic extracts that could be used in several industrial applications.
Improvement of light output power of InGaN/GaN light-emitting diode by lateral epitaxial overgrowth using pyramidal-shaped SiO_2 (2010)

We report on the improvement of light output power of InGaN/GaN blue light-emitting diodes (LEDs) by lateral epitaxial overgrowth (LEO) of GaN using a pyramidal-shaped SiO(2) mask. The light output power was increased by 80% at 20 mA of injection current compared with that of conventional LEDs without LEO structures. This improvement is attributed to an increased internal quantum efficiency by a significant reduction in threading dislocation and by an enhancement of light extraction efficiency by pyramidal-shaped SiO(2) LEO mask.
Aqueous Humor Levels of Vasoactive Molecules Correlate with Vitreous Levels and Macular Edema in Central Retinal Vein Occlusion (2010)

Our results suggest that aqueous levels of VEGF and IL-6 may reflect the vitreous levels of these molecules. Measurement of VEGF and IL-6 in the aqueous humor may be clinically useful to assess the severity of macular edema in patients with CRVO.
Enhanced tunneling spin polarization from ultrathin layers of amorphous CoFe (2009)

The tunneling spin polarization of CoFe alloys is directly compared in their amorphous (&amp;lt;∼25–30 Å) and crystalline states using superconducting tunneling spectroscopy measurements of Al95Si5/Al2O3/CoFe junctions. Ultrathin layers of normally crystalline CoFe are made amorphous by sandwiching them between amorphous alumina tunnel barriers and amorphous ferromagnetic CoFeB electrodes. The results show that the tunneling spin polarization is significantly enhanced when the CoFe alloy is made amorphous compared to when it is crystalline. We also show that a postdeposition atomic oxygen treatment of the alumina tunnel barrier significantly enhances the thermal stability of the junctions.