gebhart/patrepeval huggingface dataset:
Ultrapure Metal‐Organic Precursors for MOVPE (2019)

This chapter reviews some of the important developments in the chemistry of metal-organic (MO) precursors, which are relevant to the advancement of compound semiconductors, with an emphasis on the evolution of ultrapure MO precursors since the inception of metal-organic vapor phase epitaxy (MOVPE). It focuses on the chemistry of the synthesis and the purification of some of the most commonly used MOVPE precursors, along with relevant applications of these MOVPE precursors. The synthesis and purification strategies for MOVPE precursors are constantly evolving, with strides made towards higher purity, greater process efficiency, and safer production to ensure sustainability. The chapter looks at the most commonly used MOVPE precursors and dopants for III-V and II-VI compound semiconductors. In general terms, MOVPE precursors belong to a class of compounds comprising metals (or metalloids) and organic radicals. The environment, health, and safety aspects of MOVPE precursors are primarily associated with their pyrophoricity and health hazards related to toxicity.
Supplementary Figures 1-3 from Intracellular Tumor-Associated Antigens Represent Effective Targets for Passive Immunotherapy (2023)

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Sustainable hydrophobic thermosetting resins and polycarbonates from turpentine (2015)

The renewable phenol carvacrol has been converted to high performance polymers with low water uptake and good thermal stability.
Enzymic synthesis of sn-glycerol 3-phosphate (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnzymic synthesis of sn-glycerol 3-phosphateVictor M. Rios-Mercadillo and George M. WhitesidesCite this: J. Am. Chem. Soc. 1979, 101, 19, 5828–5829Publication Date (Print):September 1, 1979Publication History Published online1 May 2002Published inissue 1 September 1979https://pubs.acs.org/doi/10.1021/ja00513a062https://doi.org/10.1021/ja00513a062research-articleACS PublicationsRequest reuse permissionsArticle Views232Altmetric-Citations44LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Escaping the Academic Sandbox: Realizing VPR Circuits on Xilinx Devices (2013)

This paper presents a new, open-source method for FPGA CAD researchers to realize their techniques on real Xilinx devices. Specifically, we extend the Verilog-To-Routing (VTR) suite, which includes the VPR place-and-route CAD tool on which many FPGA innovations have been based, to generate working Xilinx bitstreams via the Xilinx Design Language (XDL). Currently, we can faithfully translate VPR's heterogeneous packing and placement results into an exact Xilinx `map' netlist, which is then routed by its `par' tool. We showcase the utility of this new method with two compelling applications targeting a 40nm Virtex-6 device: a fair comparison of the area, delay, and CAD runtime of academia's state-of-the-art VTR How with a commercial, closed-source equivalent, along with a CAD experiment evaluated using physical measurements of on-chip power consumption and die temperature, over time. This extended How - VTR-to-Bitstream - is released to the community with the hope that it can enhance existing research projects as well as unlock new ones.
Surgical microscope with integrated fluorescence lifetime imaging for 5-aminolevulinic acid fluorescence-guided neurosurgery (2020)

Integration of macroscopic FLIM into a surgical microscope is feasible and a promising method for improved tumor delineation.
Identification of bla OXA-51-like , bla OXA-58 , bla DIM-1 , and bla VIM Carbapenemase Genes in Hospital Enterobacteriaceae Isolates from Sierra Leone (2013)

We describe the results of a molecular epidemiological survey of 15 carbapenemase-encoding genes from a recent collection of clinical isolates from Mercy Hospital in Bo, Sierra Leone. The most salient findings revealed that (i) 60% of the isolates harbored multiple carbapenemase genes; (ii) the blaDIM-1 gene, which has previously only been reported in The Netherlands, is also circulating in this environment; and (iii) blaOXA-51-like and blaOXA-58 genes, which were thought to reside exclusively in Acinetobacter species, can also be found in members of the Enterobacteriaceae.
Effect of β-1,3/1,6-D-glucan in diet on productivity and humoral and cellular defense mechanisms in sheep (2013)

The aim of this study was to determine the effect of β-1,3/1,6-D-glucan, isolated from Saccharomyces cerevisiae , on indicators of milk and meat performance in sheep as well as on selected non-specific indicators of humoral and cellular defense. The experiment was carried on 26 suckling ewes divided into 2 equal groups, and their offspring (21 in each group). The ewes were administered concentrate with the addition of β-1,3/1,6-D-glucan at a dose of 3 g/kg. Indicators of milk performance and markers of humoral and cellular immunity were analyzed on days 28 and 70 of lactation; and the indicators of meat performance of lambs on day 28 and 70 of their life. The addition of β-1,3/1,6-D-glucan was observed to cause an increase in milk performance by 13.5–14%. Simultaneously, milk was characterized by a lower somatic cell count. Diet supplementation had a positive effect on the chemical composition of milk, which was manifested by increased percentage contents of fat (by 15– 30%) and protein (by 11%). Lambs were characterized by a higher growth rate and better muscle tissue development. The supplementation caused an increase of gamma-globulin concentration (by 6.33–9.5 g/l), lysozyme activity (by 0.1 mg/l), respiratory burst activity (by 0.11–0.14), potential killing activity (by 0.10–0.12), proliferative response of T-cells stimulated by mitogen concanavalineA (by 0.07–0.09 RI) and proliferative response of B-cells stimulated by mitogen lipopolysaccharide (by 0.13–0.16 RI) in sheep’s blood. The activity of β-1,3/1,6-D-glucan as a natural immunostimulator has been studied in many animal species, however, this is the first study conducted on sheep.
Limits of offset cancellation by the principle of spinning current hall probe (2006)

An equivalent circuit model for Hall plates with 90/spl deg/ symmetry - as are used in todays smart sensors using the principle of spinning current Hall probe - is derived. It becomes apparent that the commonly used H-bridge 4-resistor type equivalent circuit has to be completed by 2 resistors between the contacts of each diagonal. By use of this equivalent circuit, it is shown that the principle of the spinning current Hall probe works perfectly only for electrically linear probes supplied by a current source. In this case, two orthogonal current directions are enough to cancel the offset. Yet, in the case of voltage biased Hall probes, the offset is not completely eliminated. In practice, integrated Hall probes exhibit electrical nonlinearity due to the depletion layer to the substrate. Monte Carlo simulations show that this nonlinearity limits the performance of offset reduction to roughly 100 nT.
ATRT-17. TARGETING GLUTAMINE METABOLISM LOWERS METHYLATION POTENCIALS IN AT/RT AND SYNERGIZE WITH TAZEMETOSTAT (2020)

Abstract Atypical teratoid/rhabdoid tumors (AT/RT) have a single recurring genetic mutation in SMARCB1. This deletion leads to an abnormal SWI/SNF chromatin remodeling complex and the constitutive activation of EZH2. S-adenosyl-L-methionine (SAM) donates a methyl group to EZH2 which then methylates DNA and histones leading to the abnormal gene expression responsible for AT/RT’s aggressive phenotype. We have previously shown that glutamine metabolic inhibition with 6-diazo-5-oxo-L-norleucine (DON) confers a survival advantage in AT/RT. In this study, we identified with ultra-high performance liquid chromatography mass spectrometry that DON treatment lowered the methylation potential in AT/RT (Decreased SAM:SAH ratio, t-test in 5 AT/RT human-derived cell models comparing DON treatment to DMSO control, p&amp;lt;0.05). AT/RT cell lines grown in glutamine deplete media compared to normal growth conditions also had a reduced methylation potential (decreased SAM:SAH, t-test, p&amp;lt;0.05). DON treatment over 5 days decreased histone methylation (as determined by western blot for H3K27me3). Tazemetostat is a small molecule inhibitor that blocks the SAM methyl donor site on EZH2. We find that DON combines synergistically with Tazemetostat to slow AT/RT cell growth (MTS assay, p&amp;lt;0.01 t-test; MUSE viability assay, p&amp;lt;0.01 ANOVA) and enhances cytotoxicity (MUSE Annexin-V, p&amp;lt;0.01 by ANOVA). Synergies were especially pronounced at low concentrations of Tazemetostat which is significant given that Tazemetostat’s efficacy in AT/RT has been limited by poor CNS penetration. These studies identify a novel treatment strategy that has potential to improve survival in AT/RT.
Evaluation of a New 177Lu-Labeled Somatostatin Analog for the Treatment of Tumors Expressing Somatostatin Receptor Subtypes 2 and 5 (2020)

Targeted radionuclide therapy of somatostatin receptor (SST)-expressing tumors is only partially addressed by the established somatostatin analogs having an affinity for the SST subtype 2 (SST2). Aiming to target a broader spectrum of tumors, we evaluated the bis-iodo-substituted somatostatin analog ST8950 ((4-amino-3-iodo)-d-Phe-c[Cys-(3-iodo)-Tyr-d-Trp-Lys-Val-Cys]-Thr-NH<sub>2</sub>), having subnanomolar affinity for SST2 and SST5, labeled with [<sup>177</sup>Lu]Lu<sup>3+</sup> via the chelator DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid). Human Embryonic Kidney (HEK) cells stably transfected with the human SST2 (HEK-SST2) and SST5 (HEK-SST5) were used for in vitro and in vivo evaluation on a dual SST2- and SST5-expressing xenografted mouse model. <sup>nat</sup>Lu-DOTA-ST8950 showed nanomolar affinity for both subtypes (IC<sub>50</sub> (95% confidence interval): 0.37 (0.22-0.65) nM for SST2 and 3.4 (2.3-5.2) for SST5). The biodistribution of [<sup>177</sup>Lu]Lu-DOTA-ST8950 was influenced by the injected mass, with 100 pmol demonstrating lower background activity than 10 pmol. [<sup>177</sup>Lu]Lu-DOTA-ST8950 reached its maximal uptake on SST2- and SST5-tumors at 1 h p.i. (14.17 ± 1.78 and 1.78 ± 0.35%IA/g, respectively), remaining unchanged 4 h p.i., with a mean residence time of 8.6 and 0.79 h, respectively. Overall, [<sup>177</sup>Lu]Lu-DOTA-ST8950 targets SST2-, SST5-expressing tumors in vivo to a lower extent, and has an effective dose similar to clinically used radiolabeled somatostatin analogs. Its main drawbacks are the low uptake in SST5-tumors and the persistent kidney uptake.
System Design of Cooperative Wireless Networks (2014)

With the prediction that the number of wireless devices will reach tens of billions by 2020, wireless networks that exist today will have to be reengineered to support the increase in the number of users and the required capacity. Cooperation among terminals is envisioned as an enabling technique that can benefit from the increased number of connected devices and boost the network capacity beyond what is possible with today's network architectures, which rely on direct source-destination transmissions. While most of the work in this area focuses on designing relaying schemes that can achieve the promised capacity increase, little has been done in terms of implementing practical cooperative systems. To implement cooperation among terminals, a number of practical challenges need to be addressed across several layers of the communication system. This work focuses on the design aspects of physical and MAC communication layers, by suggesting low-complexity signal processing algorithms for multi- device cooperation and designing digital baseband hardware that showcases cooperation between two wireless devices.We use the quantize-map-and-forward (QMF) relaying scheme, which has been shown to have good theoretical performance with multiple relays. System design of a cooperative communication link with half-duplex QMF relays is presented in three steps. First, we perform a theoretical analysis of the achievable rate and propose a local relay scheduling algorithm that performs close to the optimal relay scheduling algorithm. This local scheduling algorithm, as well as the system design approach in general, is based on the premise that relay terminals can be oblivious to other relays in the network. We show that spectral efficiency scaling with the number of relays achieved with this approach is close to optimal for both slow and fast- fading channel environments. The performance of a physical layer system design procedure for a QMF link is demonstrated by an example in which the spectral efficiency of a direct link is doubled by cooperating with three relays close to the source, as predicted by the theoretical analysis. Finally, we design the main baseband blocks for the three cooperating terminals in hardware and implement them on FPGAs. We show that the complexity of the cooperative receiver's baseband increases by 40% compared to a direct-link receiver.
Direct-impact Hopkinson tests on the Ti-6Al-4V alloy at very high strain rate and inverse identification of elastic-viscoplastic constitutive models (2015)

Colloque avec actes et comité de lecture. Internationale.
Directional Sound Detection by Sensing Acoustic Flow (2018)

The ability to determine the direction of propagation of an acoustic wave is crucial to sound source detection, localization, and identification. Current techniques based on sensing acoustic pressure using membranes at multiple spatial locations tend to have directionality and output sensitivity that depend strongly on the sound frequency, which compromises performance, especially in miniaturized applications. Unlike pressure, which is a scalar, the fluctuating flow of the acoustic medium (i.e., the acoustic particle velocity) is a vector, which inherently contains the direction information of sound propagation. Here, we experimentally demonstrate an alternative, and more direct, method of directional sound detection by sensing acoustic flow using nanofibers, which are driven by viscous forces applied by the fluctuating medium. The measured output signal of this prototype sensor exhibits bidirectional response and flat frequency response across a wide range of frequencies from 100 Hz to 10000 Hz. While pressure-sensing microphones now enjoy an annual market in the billions of units sold, a broadband sound flow sensor with almost full fidelity will provide considerable benefits.
PCR-like Cascade Reactions in the Context of an Allosteric Enzyme Mimic (2008)

A supramolecular allosteric catalyst that exhibits a PCR-like cascade reaction is reported. The complex is triggered by a reaction with an acetate ion, which turns on a catalytic cascade that exponentially increases acetate ion concentration through an acyl transfer reaction.
Recent Advances in the Medicinal Chemistry of Polyamine Toxins (2001)

This review describes the recent developments in the field of polyamine toxins, with focus on structure activity relationship investigations, including studies of importance of the polyamine moiety for biological activity, photolabeling studies using polyamine toxins as templates, as well as use of solid phase methods for the synthesis of polyamine toxins. The review is mainly concerned with effects of polyamine toxins on nicotinic acetylcholine receptors and ionotropic glutamate receptors.
Evaluation of current reference generation methods for a three-phase inverter interfacing renewable energy sources to generalized micro-grid (2011)

In this paper, different methods of deriving the grid current references for a three-phase renewable energy based inverter connected to generalized micro-grid system are compared. The three-phase micro-grid voltage is considered to have unbalance as well as harmonic contamination. Primarily the p-q and FBD theory based methods are compared in terms of different specifications like manifestation of DC link side ripples, computational power required for implementation and restriction on the power circuit topology. Another method, equal phase active power sharing is also compared with these well known methods and its effect on the power circuit topology is also investigated. The comparisons are carried out based on the mathematical analysis and the experimental results under different operating conditions.
Quartz Crystal Microbalance Study for Lithium Deposition and Dissolution in Nonaqueous Electrolyte with HF (1999)

An irreversible consumption of lithium during deposition and dissolution in nonaqueous electrolytes with a small amount of HF was studied by an electrochemical in situ QCM technique. From this measurement, it can be seen that lithium is not only consumed by some chemical reactions with the electrolyte during the deposition process, but is also lost during the dissolution process. This result is strongly related to a breakdown of a surface film formed on lithium during the deposition process. This means that the dissolution process of lithium has to be extensively studied to obtain a high coulombic efficiency.
Experimental platform for waveform optimization in passive UHF RFID systems (2020)

The article presents an experimental platform, so called “RFID Waveformer,” dedicated to the study of waveform optimization in the radio frequency identification (RFID) context. It is a flexible solution that enables waveform design and their energetic performance evaluation in a ultra high frequency (UHF) RFID link following the ISO-18000 GEN2 standard protocol. It consists of a reader emulated by a LabVIEW interface controlling radiofrequency laboratory instruments, which perform real time tag response detection. Its interconnection with MATLAB routines enables the design and the evaluation of arbitrarily shaped RFID waveforms. In this article, for illustration, three waveforms are tested with RFID Waveformer in a complex propagation environment: pulsed wave (PW) and time reversal (TR) modes compared to the traditional continuous wave (CW) mode. Experimental results show that both PW and TR modes improve the energetic efficiency of the forward link and so the RFID read range compared to CW mode. Furthermore, TR presents the optimal efficiency in complex propagation medium. The RFID Waveformer enables tag response detection in the three modes offering ease of use and repeatability of measurements. The RFID Waveformer being not limited to the scenario considered in this article, it is a versatile solution extendable to other contexts.
Memory and Energy Storage Dual Operation in Chalcogenide-Based CBRAM (2017)

In this paper, we demonstrated memory and energy storage dual operation in GeS2/Ag conducting bridge RAM. Both operations are based on electrochemical reactions and Ag diffusion in the GeS2 electrolyte. Depending on specific bias and current conditions, the same device can be used for data or energy storage: in memory mode, Ag-based filament is formed in GeS2, while in energy storage mode, Ag bulk diffusion is achieved. Voltage sweep and constant current stress cycling modes for energy storage are evaluated, and the total stored charge is quantified. These obtained results open the path for new autonomous or ultra-low power circuits, integrating dual operation devices composed of the same stack, where energy storage devices could provide energy to the memory array.
Changes in CpG Islands Promoter Methylation Patterns during Ductal Breast Carcinoma Progression (2009)

Aberrant promoter methylation of several known or putative tumor suppressor genes occurs frequently during carcinogenesis, and this epigenetic change has been considered as a potential molecular marker for cancer. We examined the methylation status of nine genes (APC, CDH1, CTNNB1, TIMP3, ESR1, GSTP1, MGMT, THBS1, and TMS1), by quantitative methylation specific PCR. Synchronous preinvasive lesions (atypical ductal hyperplasia and/or ductal carcinoma in situ) and invasive ductal breast carcinoma from 52 patients, together with pure lesions from 24 patients and 12 normal tissues paired to tumor and 20 normal breast distant from tumor were analyzed. Aberrant promoter methylation was detected in both preinvasive and invasive lesions for genes APC, CDH1, CTNNB1, TIMP3, ESR1, and GSTP1. However, hierarchical mixed model and Generalized Estimating Equations model analyses showed that only APC, CDH1, and CTNNB1 promoter regions showed a higher frequency and methylation levels in pathologic samples when compared with normal breast. Whereas APC and CTNNB1 did not show differences in methylation levels or frequencies, CDH1 showed higher methylation levels in invasive tumors as compared with preinvasive lesions (P < 0.04, Mann-Whitney test with permutation correction). The analysis of APC, CDH1, and CTNNB1 methylation status was able to distinguish between normal and pathologic samples with a sensitivity of 67% (95% confidence interval, 60-71%) and a specificity of 75% (95% confidence interval, 69-81%). Our data point to the direct involvement of APC, CDH1, and CTNNB1 promoter methylation in the early stages of breast cancer progression and suggest that they may represent a useful tool for the detection of tumor cells in clinical specimens.
Cavitation from short acoustic pulses (1985)

It has recently been predicted [H. G. Flynn, J. Acoust. Soc. Am. 72, 1926–1932 (1982)] that short, microsecond bursts of ultrasound could produce transient cavitation. We wish to report an experimental verification of this prediction. Using chemiluminescence as a cavitation indicator, we have observed light emissions indicating cavitation at a threshold of approximately 2.0 MPa for a pulse width of 1.0 μs at a frequency of 1.0 MHz and a duty cycle of 1:10. A description of the apparatus and a report on our latest results will be given. [Supported in part by the NSF and the FDA.]