gebhart/patrepeval huggingface dataset:
Creation of non-virtual acoustic images in three dimensions and applications in NDT (2014)

One of the major forth-comings of modern NDT is the availability to image certain areas of interest of a work-piece to the most detailed extend achievable within the resolution limit. The major efforts have been undertaken on the receiver side in order to correct the spatial and temporal characteristics of the reflection of ultrasonic signals. Only few approaches have been realized on the transmitter side, one of which is the Time Reverse Mirror method [1, 2, 3]. Within this approach, analog excitation functions are recorded from the reflections created by discontinuities from an incident plane wave, which is similar to the recording process of an optical hologram. With the upcoming of 2D arrays, this approach is getting significant interest, in particular, because with those it is possible to generate 3-dimensional acoustic images. In this paper we present the approach of a computer holographic generation of the excitation functions. Assuming a real acoustic image shall be created, this method can be used to calculate the excitation functions, which are needed to be imposed onto the transmitters in order to generate this image. This method therefore allows tailoring the ultrasonic transmission to the testing scenario considering in particular the geometric and acoustic conditions. If applied in conjunction with the Paint-Brush technology[4], or any type of image reconstructing algorithm on the receiver side (e.g. DDF/DDA[5]), this transmission method can be flexibly applied throughout the NDT-applications.
IMMUNOSPECIFIC DEPLETION OF GRAFT-VERSUS-HOST-REACTIVE LYMPHOCYTES USING SENSITIZED SYNGENEIC INITIATOR T LYMPHOCYTES (1979)

We investigated a model of a lethal graft-versus-host (GVH) reaction with the aim of depleting donor spleen cells of immunospecific GVH-reactive lymphocytes. In previous studies of the recruitment of effector T lymphocytes by sensitized syngeneic initiator T lymphocytes (ITLs) we found, using a local GVH reaction, that precursors of specific GVH-reactive lymphocytes were recruited to a draining lymph node. In this study, adult F1 hybrid mice were lethally irradiated and reconstituted with 2 × 106 syngeneic bone marrow cells and varying numbers of spleen cells from parental strain mice. To deplete donor spleen cells of GVH-reactive lymphocytes, parental strain mice were given injections in the hind footpads 6 days earlier of syngeneic ITLs that had been sensitized in vitro against allogeneic fibroblasts. We found that injection of ITLs sensitized against the relevant allogeneic antigens led to a marked decrease in the specific GVH potential of donor spleen cells. These findings show that GVH-reactive lymphocytes can be depleted selectively by activating their recruitment to particular lymph nodes, using syngeneic ITLs.
Targeting Stereotactic Body Radiotherapy on Metabolic PET- and Immuno-PET-Positive Vertebral Metastases (2020)

(1) Background: Stereotactic body radiotherapy (SBRT) for vertebral metastases (VM) allows the delivery of high radiation doses to tumors while sparing the spinal cord. We report a new approach to clinical target volume (CTV) delineation based on anti-carcinoembryonic antigen (CEA) positron emission tomography (pretargeted immuno-PET; “iPET”) in patients with metastatic breast cancer (BC) or medullary thyroid cancer (MTC). (2) Methods: All patients underwent iPET, spine magnetic resonance imaging (MRI), and positron emission tomography-computed tomography (PET-CT) using 18F-deoxyglucose (FDG) for BC or 18F-dihydroxy-phenylalanine (F-DOPA) for MTC. Vertebrae locations and vertebral segments of lesions were recorded and the impact on CTV delineation was evaluated. (3) Results: Forty-six VM eligible for SBRT following iPET were evaluated in eight patients (five BC, three MTC). Eighty-one vertebral segments were detected using MRI, 26 with FDG or F-DOPA PET/CT, and 70 using iPET. iPET was able to detect more lesions than MRI for vertebral bodies (44 vs. 34). iPET-based delineation modified MRI-based CTV in 70% (32/46) of cases. (4) Conclusion: iPET allows a precise mapping of affected VM segments, and adds complementary information to MRI in the definition of candidate volumes for VM SBRT. iPET may facilitate determining target volumes for treatment with stereotactic body radiotherapy in metastatic vertebral disease.
Synthesis and Properties of NitroHPHAC: The First Example of Substitution Reaction on HPHAC (2020)

Hexapyrrolohexaazacoronene (HPHAC) is one of the N-containing polycyclic aromatic hydrocarbons in which six pyrroles are fused circularly around a benzene. Despite the recent development of HPHAC analogues, there is no report on direct introduction of functional groups into the HPHAC skeleton. This work reports the first example of nitration reaction of decaethylHPHAC. The structures of nitrodecaethylHPHAC including neutral and two oxidized species (radical cation and dication), intramolecular charge transfer (ICT) character, and global aromaticity of the dication are discussed.
Simulation of flow around a thick airfoil with a vortex trapping cavity (2013)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation F. Saeed, M. Basha, A. Z. Al-Garni; Simulation of flow around a thick airfoil with a vortex trapping cavity. AIP Conference Proceedings 17 October 2013; 1558 (1): 236–239. https://doi.org/10.1063/1.4825464 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Measuring line roughness through aerial image contrast variation using coherent extreme ultraviolet spatial filtering techniques (2005)

Line edge roughness properties for an extreme ultraviolet photoresist (Rohm and Haas/Shipley 1K) were investigated by varying the aerial image contrast of dense line and space patterns. Aerial image contrast variation was performed in single exposures by programming the modulation information on the mask. No background flood exposures were needed to reduce the contrast. The Micro Exposure Tool at Lawrence Berkeley National Laboratory was used for these experiments. Dense 50nm lines and spaces were printed with contrast levels ranging from 86.4% to 46.8%. Coherence was programmed to be 0.1 for these experiments. Results show that an increase in the aerial image contrast causes a subsequent decrease in the line edge roughness (LER). Similar effects are seen for linewidth roughness (LWR). The LER varied from 3.3nm (at 86.4% contrast) to 8.0nm (at 46.8% contrast). LWR varied from 5.3nm (at 86.4% contrast) to 12.8nm (at 46.8% contrast). All values are three sigma root-mean-square. Only a couple of dense 30nm features would print in this configuration. For these 30nm lines and spaces, the best LER was 5.6nm and LWR was 11.3nm.
P2‐354: Synaptic Membrane Synthesis in Rats is Increased by Dietary Supplementation with Uridine and Docosahexaenoic Acid and Depends on Antioxidant Supplementation (2016)

The nutritional precursors for phospholipid synthesis, uridine and the polyunsaturated fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), have been shown to enhance levels of brain phospholipids and synaptic proteins in rodents (Wurtman, et al. Brain Res. 2006; Cansev, et al. Neuroscience. 2007). Existing information suggest that supplementation with various antioxidants (AOX) may improve neuronal membrane formation and function. The present study investigated the additional value of vitamin C, vitamin E and selenium in rats supplemented with uridine (as uridine-5’-monophosphate) and fish oil (FO), containing DHA and EPA. Rats were randomized to four treatment groups and received, for 6 weeks, either a control diet or a FO plus uridine diet that were either supplemented with antioxidants (AOX high) or were nearly devoid of antioxidants (AOX low). On completion of dietary treatment, rats were sacrificed, and brain and blood samples were analyzed for levels of phospholipids, synaptic proteins, and fatty acid composition. The data show that levels of total and individual phospholipids (except for phosphatidylinositol), as well as those of the pre- and post-synaptic proteins Synapsin-1 and PSD-95, were significantly enhanced by combined supplementation of FO plus uridine and AOX and not enhanced by supplementation of FO plus uridine without AOX. Brain and plasma DHA, EPA and total omega-3 fatty acids increased while arachidonic acid (AA) and total omega-6 fatty acids were decreased in rats receiving the FO plus uridine. Our data suggest that the antioxidants, vitamin C, vitamin E and selenium, in a diet containing phospholipid precursors are essential for the precursors’ effects on increasing levels of membrane phospholipids and synaptic proteins, the indirect indicators of synaptogenesis.
Supplementary Table 4 from Identification of microRNA-135b in Stool as a Potential Noninvasive Biomarker for Colorectal Cancer and Adenoma (2023)

&lt;p&gt;PDF file - 16KB, Sensitivity and specificity of miRNA markers.&lt;/p&gt;
208203 Improvement of A Robot Finger Using Electro-conjugate Fluid (2011)

Electro-conjugate fluid (ECF) is a kind of functional fluid, which produces a jet flow (ECF jet) when subjected to high DC voltage. It is possible to develop a novel robot finger/hand integrated with a pump and a tank by using ECF as a power source. The purpose of this study is improvement of the ECF robot finger we have been proposed. First, we propose a new type ECF jet generator which is a micro power source of the robot finger. Next, we characterize a flexible finger which newly has a strain gauge to detect a displacement of the finger. Finally, we develop a new robot finger which mainly composed of the ECF jet generator and the flexible finger, and demonstrate that the performance of the robot finger was improved.
In Vitro and In Vivo Efficacy of a Novel and Long-Acting Fungicidal Azole, PC1244, on Aspergillus fumigatus Infection (2018)

The antifungal effects of the novel triazole PC1244, designed for topical or inhaled administration, against <i>Aspergillus fumigatus</i> were tested in a range of <i>in vitro</i> and <i>in vivo</i> studies. PC1244 demonstrated potent antifungal activities against clinical <i>A. fumigatus</i> isolates (<i>n</i> = 96) with a MIC range of 0.016 to 0.25 μg/ml, whereas the MIC range for voriconazole was 0.25 to 0.5 μg/ml. PC1244 was a strong tight-binding inhibitor of recombinant <i>A. fumigatus</i> CYP51A and CYP51B (sterol 14α-demethylase) enzymes and strongly inhibited ergosterol synthesis in <i>A. fumigatus</i> with a 50% inhibitory concentration of 8 nM. PC1244 was effective against a broad spectrum of pathogenic fungi (MIC range, <0.0078 to 2 μg/ml), especially <i>Aspergillus terreus</i>, <i>Trichophyton rubrum</i>, <i>Candida albicans</i>, <i>Candida glabrata</i>, <i>Candida krusei</i>, <i>Cryptococcus gattii</i>, <i>Cryptococcus neoformans</i>, and <i>Rhizopus oryzae</i> PC1244 also proved to be quickly absorbed into both <i>A. fumigatus</i> hyphae and bronchial epithelial cells, producing persistent antifungal effects. In addition, PC1244 showed fungicidal activity (minimum fungicidal concentration, 2 μg/ml) which indicated that it was 8-fold more potent than voriconazole. <i>In vivo</i>, once-daily intranasal administration of PC1244 (3.2 to 80 μg/ml) to temporarily neutropenic, immunocompromised mice 24 h after inoculation with itraconazole-susceptible <i>A. fumigatus</i> substantially reduced the fungal load in the lung, the galactomannan concentration in serum, and circulating inflammatory cytokine levels. Furthermore, 7 days of extended prophylaxis with PC1244 showed <i>in vivo</i> effects superior to those of 1 day of prophylactic treatment, suggesting accumulation of the effects of PC1244. Thus, PC1244 has the potential to be a novel therapy for the treatment of <i>A. fumigatus</i> infection in the lungs of humans.
Design Considerations and Experimental Results of a 60 W Compressed-Air-to-Electric-Power System (2008)

In many process applications, where a pressure reduction is required the energy ends up being dissipated as heat. Examples are throttling valves of gas pipelines and automotive engines or turbo expanders as used in cryogenic plants. With a new pressure reduction system that produces electricity while expanding the gas, this lost energy can be recovered. To achieve a high power density this energy generation system requires an increased operating speed of the electrical machine and the turbomachinery. This paper proposes a miniature compressed-air-to-electric-power system, based on a single-stage axial impulse turbine with a rated rotational speed of 350000 rpm and a rated electric power output of 60 W. A comprehensive description including turbine and permanent magnet (PM) generator is given and measurements like maximum electric output power of 124 W and maximum system efficiency of 24% are presented.
Recommendations for Workforce Development in Regenerative Medicine Biomanufacturing (2021)

In its 2019 report, The Skilled Technical Workforce: Crafting America's Science and Engineering Enterprise, the National Science Board recommended a national charge to create a skilled technical workforce (STW) driven by science and engineering. The RegenMed Development Organization (ReMDO), through its RegeneratOR Workforce Development Initiative, has taken on this challenge beginning with an assessment of regenerative medicine (RM) biomanufacturing knowledge, skills, and abilities (KSAs) needed for successful employment. While STW often refers only to associate degree or other prebaccalaureate prepared technicians, the RM biomanufacturing survey included responses related to baccalaureate prepared technicians. Three levels of preparation were articulated in the research: basic employability skills, core bioscience skills, and RM biomanufacturing technical skills. The first two of these skill levels have been defined by previous research and are generally accepted as foundational-the Common Employability Skills developed by the National Network of Business and Industry Associations and the Core Skill Standards for Bioscience Technicians developed by the National Center for the Biotechnology Workforce. Fifteen skill sets addressing the specialized needs of RM and related biotechnology sectors were identified in the ReMDO survey, defining a third level of KSAs needed for entry-level employment in RM biomanufacturing. The purpose of the article is to outline the KSAs necessary for RM biomanufacturing, quantify the skills gap that currently exists between skills required by employers and those acquired by employees and available in the labor market, and make recommendations for the application of these findings.
ChemInform Abstract: The Enantioselective Conversion of Ortho‐Substituted Benzoic Acids to Chiral Cyclohexane Derivatives. (1986)

Abstract Die chiralen N‐Benzoylpyrrolidine (I) lassen sich durch reduktive Birch‐Methylierung stereoselektiv zu den Dihydrobenzamiden (III) umsetzen; das Toluylpyrrolidin (IV) liefert entsprechend das diastereomere Dimethyldihydrobenzamid (V).
Life Cycle Assessment Overview and Application: Comparison of Structural Frame Alternatives for Office Buildings (2021)

The objective of this project was to provide an overview of Life Cycle Assessment (LCA) and to demonstrate its application as a tool to provide a scientific comparison of alternative construction options for a commercial building in the Canadian context. The work entailed a quantitative assessment of the embodied environmental impacts of typical office buildings using a steel frame, and a concrete frame alternative (and associated components) in Toronto. Through the use of four assessment strategies, this study has indicated that the steel framed building performs better than the concrete building in most impact indicators, excepting primary energy and eutrophication potential. However, additional buildings should be assessed in order to confirm this finding. Furthermore, it was found that the manufacturing phase represents over 90% of the embodied impacts of the whole building. The study also advises caution when comparing different LCA studies and identifies its difficulties.
Verification modulo versions (2014)

We introduce Verification Modulo Versions (VMV), a new static analysis technique for reducing the number of alarms reported by static verifiers while providing sound semantic guarantees. First, VMV extracts semantic environment conditions from a base program P. Environmental conditions can either be sufficient conditions (implying the safety of P) or necessary conditions (implied by the safety of P). Then, VMV instruments a new version of the program, P', with the inferred conditions. We prove that we can use (i) sufficient conditions to identify abstract regressions of P' w.r.t. P; and (ii) necessary conditions to prove the relative correctness of P' w.r.t. P. We show that the extraction of environmental conditions can be performed at a hierarchy of abstraction levels (history, state, or call conditions) with each subsequent level requiring a less sophisticated matching of the syntactic changes between P' and P. Call conditions are particularly useful because they only require the syntactic matching of entry points and callee names across program versions. We have implemented VMV in a widely used static analysis and verification tool. We report our experience on two large code bases and demonstrate a substantial reduction in alarms while additionally providing relative correctness guarantees.
Efficacy and Safety of Dapagliflozin in Heart Failure With Mildly Reduced or Preserved Ejection Fraction According to Age: The DELIVER Trial (2022)

gov; Unique identifier: NCT03619213.
Uracil Derivatives for Halogen-Bonded Cocrystals (2021)

Among non-covalent interactions, halogen bonding is emerging as a new powerful tool for supramolecular self-assembly. Here, along with a green and effective method, we report three new halogen-bonded cocrystals containing uracil derivatives and 1,2,4,5-tetrafluoro-3,6-diiodobenzene as X-bond donor coformer. These multicomponent solids were prepared both by solvent-drop grinding and solution methods and further characterized by powder and single-crystal X-ray diffraction, Fourier-transformed infrared spectroscopy, and thermal methods (TGA-DSC). In order to study the relative importance of hydrogen versus halogen bonds in the crystal packing, computational methods were applied.
Effects of unsteady blowing through a spanwise slot on a turbulent boundary layer (2006)

The effects of localized periodic blowing on a turbulent boundary layer were investigated by direct numerical simulation. Time-periodic blowing was applied through a spanwise slot by varying the wall-normal velocity in a cyclic manner from 0 to $2A^ + $ . Time-periodic blowing was applied at frequencies in the range $0\,{ \le}\, f^ +\,{ \le}\, 0.08$ at a fixed blowing amplitude of $A^ + $ = 0.5. Simulations of a spatially evolving turbulent boundary layer were carried out for two Reynolds numbers, $\hbox{\it Re}_{\theta, in} $ = 300 and 670. Before investigating the effects of periodic blowing, the effects of steady blowing were examined. A new parameter, $\sigma ^ + $ , was proposed for describing local blowing; the usefulness of this parameter was that the responses of the flow variables at the two Reynolds numbers were the same for the same $\sigma ^ + $ . The effects of varying the blowing frequency were scrutinized by examining the phase- or time-averaged turbulent statistics. For both Reynolds numbers, application of blowing at a frequency of $f^ + $ = 0.035 was found to give the maximum increases in Reynolds shear stress, streamwise vorticity fluctuations and energy redistribution. Analysis of the Reynolds stress budget showed that this effective blowing frequency induced the greatest enhancement of the pressure–strain term, which is closely related to the energy redistribution. Analysis of the phase-averaged stretching and tilting terms revealed that the stretching term is significantly enhanced in the ‘downward’ motion that is induced by the spanwise vortical motion. The correlation between the streamwise vorticity and the stretching term changed in magnitude and length scale as the blowing phase was varied, whereas the correlation between the streamwise vorticity and the tilting term did not.
Skewed CMOS: noise-tolerant high-performance low-power static circuit family (2002)

In this paper, we present a noise-tolerant high-performance static circuit family suitable for low-voltage operation called skewed logic. Skewed logic circuits in comparison with Domino logic have better scalability and are more suitable for low voltage applications because of better noise margins. Skewed logic and its variations have been compared with Domino logic in terms of delay, power, and dynamic noise margin. A design methodology for skewed CMOS pipelined circuits has been developed. To demonstrate the applicability of the proposed logic style, 0.35 /spl mu/m 5.56 ns CMOS 16/spl times/16 bit multipliers have been designed using skewed logic circuits and fabricated through MOSIS. Measurement results show that the multiplier only consumed a power of 195 mW due to its low clock load.
Secure and Efficiently Searchable IoT Communication Data Management Model: Using Blockchain as a New Tool (2021)

With the rapid development of the Internet of Things (IoT), more IoT devices are connected in the same network and communicate frequently for sharing data and switching instructions. So that the traditional centralized security architecture of IoT will be limited in terms of data storage space, data reliability, scalability, and operating costs. In this article, we propose a novel communication data management model based on blockchain technology. Specifically, all encrypted IoT communication data files are uploaded to the public cloud server for obtaining enough storage space, but the key information extracted from these data files (called “communication logs”) will be recorded in an “IoT ledger” maintained by all IoT devices. In fact, the IoT ledger is a kind of blockchain structured distributed database, which can solve the problem of data reliability, scalability and would not involve high operating costs. Besides, in order to efficiently search communication logs and not reveal any sensitive information of communication data, we design a secure search scheme over such blockchain database, the asymmetric scalar-product-preserving encryption (ASPE) approach is exploited to guarantee the data security, and the two layers index improves the search efficiency. Security analysis and experiments on synthetic data set show that our scheme is secure and efficient.
Supplementary Movie 1 from Depletion of the Ras Association Domain Family 1, Isoform A–Associated Novel Microtubule-Associated Protein, C19ORF5/MAP1S, Causes Mitotic Abnormalities (2023)

Supplementary Movie 1 from Depletion of the Ras Association Domain Family 1, Isoform A–Associated Novel Microtubule-Associated Protein, C19ORF5/MAP1S, Causes Mitotic Abnormalities
Proof of Principle in the Selective Treatment of Cancer by Antibody-Directed Enzyme Prodrug Therapy: The Development of a Highly Potent Prodrug (2002)

Ein vielversprechender Ansatz für die Tumortherapie: Mit dem seco-CBI-Q-Galactosid 1 wurde ein neues hochwirksames Prodrug für eine selektive Tumortherapie unter Verwendung des ADEPT-Ansatzes entwickelt, das sehr gute präklinische Ergebnisse bei der Behandlung eines humanen Lungenkarzinoms im SCID-Maus-Modell zeigt (siehe Bild; Lungengewebe nach (A) und vor Behandlung (B)).