gebhart/patrepeval huggingface dataset:
Double-Diffusive Natural Convection in a Porous Medium under Constant Heat and Mass Fluxes. (1997)

Double-diffusive natural convection in a rectangular fluid-saturated porous medium has been studied analytically and numerically. The analysis reveals that there is a range of buoyancy ratio N in which one obtains two types of solutions or oscillating convection. In the case of 0.4<N<1.0, there exist two analytical solutions when RC=100 and Le=30. In that case, two solutions, temperature-dominated and concentration-dominated solutions, are calculated when aspect ratio is small. It is found that the oscillation is due to temporal formation of a two-roll flow pattern in the cavity when aspect ratio is sufficiently large. The oscillation of time-dependent Nusselt number and flow patterns are shown.
Postoperative Modifications of Cardiovascular Control and Baroreflex Sensitivity in Patients Undergoing Surgical Aortic Valve Replacement (2020)

Time and frequency domains indexes derived from spontaneous fluctuations of heart period (HP) and systolic arterial pressure (SAP) and baroreflex sensitivity (BRS) are usually exploited to assess the state of the autonomic control. Surgical aortic valve replacement (SAVR) features postoperative complications, such as atrial fibrillation, that can be favored by an impairment of cardiovascular autonomic control. We computed HP and SAP variability markers in time and frequency domains and BRS via transfer function analysis in seven patients one day before (PRE) and 7 days after (POST) SAVR surgery. Indexes were assessed at rest in supine position (REST) and during active standing (STAND). No autonomic regulatory response to STAND was detected either in PRE or POST sessions. In POST at REST a remarkable depression of BRS indexes was observed compared to PRE, thus suggesting an increased risk for postoperative adverse events and prompting for the search of suitable countermeasures.
Fusion engineering device magnetic systems design (1981)

The FED magnetic system provides the basic mechanism for both plasma confinement and control. The magnet system must meet high standards of reliability. It has been assumed in the FED design that all superconducting magnets are designed for the lifetime of the device. This paper describes design concepts for toroidal field and poloidal field magnet systems.
Matrix-based Kernel Principal Component analysis for large-scale data set (2009)

Kernel Principal Component Analysis (KPCA) is a nonlinear feature extraction approach, which generally needs to eigen-decompose the kernel matrix. But the size of kernel matrix scales with the number of data points, it is infeasible to store and compute the kernel matrix when faced with the large-scale data set. To overcome computational and storage problem for large-scale data set, a new framework, Matrixbased Kernel Principal Component Analysis (M-KPCA), is proposed. By dividing the large scale data set into small subsets, we could treat the autocorrelation matrix of each subset as the special computational unit. A novel polynomial-matrix kernel function is adopted to compute the similarity between the data matrices in place of vectors. It is also proved that the polynomial kernel is the extreme case of the polynomial-matrix one. The proposed M-KPCA can greatly reduce the size of kernel matrix, which makes its computation possible. The effectiveness is demonstrated by the experimental results on the artificial and real data set.
Gigapixel Imaging with the AWARE Multiscale Camera (2012)

Gigapixel cameras have been confined to specialized applications such as aerial photography and astronomical observatories. A simplified architecture would better suit terrestrial imaging and reduce instrument cost and complexity. Our gigapixel AWARE camera is based on monocentric multiscale optical design principles that produce high-resolution images with a field of view (FOV) limited only by vignetting. This design allows resolution to approach the theoretical diffraction limits for a given entrance pupil size and FOV.
Statistical Modeling of Ultrawideband MIMO Propagation Channel in a Warehouse Environment (2016)

This paper describes an extensive propagation channel measurement campaign in a warehouse environment for line-of-sight (LOS) and nonline-of-sight (NLOS) scenarios. The measurement setup employs a vector network analyzer operating in the 2-8-GHz frequency band combined with an 8 × 8 virtual multiple-input multiple-output (MIMO) antenna array. We develop a comprehensive statistical propagation channel model based on high-resolution extraction of multipath components and subsequent spatiotemporal clustering analysis. The intracluster direction of departure (DoD), direction of arrival (DoA), and the time of arrival (ToA) are independent, both for the LOS and NLOS scenarios. The intracluster DoD and DoA can be approximated by the Laplace distribution, and the intracluster ToA can be approximated by an exponential mixture distribution. The intercluster analysis, however, shows a dependency between the cluster DoD, DoA, and ToA. To capture this dependency, we separately model the clusters caused by single and multiple bounce scattering along the aisles in the warehouse. The intercluster DoD distribution follows a Laplace distribution, while the cluster DoA conditioned on the DoD is approximated by a Gaussian mixture distribution. The model was validated using the capacity and delay-spread values.
Breast Cancer Cryoablation: Assessment of the Impact of Fundamental Procedural Variables in an In Vitro Human Breast Cancer Model (2020)

In summary, these in vitro findings suggest that freezing to temperatures of 25°C results in a high degree of breast cancer cell destruction. Furthermore, the data demonstrate that the application of a repeat freeze procedure with a passive 5-minute or 10-minute thaw interval between freeze cycles increases the minimal lethal temperature to the -15°C to -20°C range. The data also demonstrate that the use of an active thawing procedure between freezes reduces ablation efficacy at temperatures associated with the iceball periphery. These findings may be important to improving future clinical applications of cryoablation for the treatment of breast cancer.
Innate Recognition of Intracellular Bacterial Growth Is Driven by the TIFA-Dependent Cytosolic Surveillance Pathway (2017)

Intestinal epithelial cells (IECs) act as sentinels for incoming pathogens. Cytosol-invasive bacteria, such as Shigella flexneri, trigger a robust pro-inflammatory nuclear factor κB (NF-κB) response from IECs that is believed to depend entirely on the peptidoglycan sensor NOD1. We found that, during Shigella infection, the TRAF-interacting forkhead-associated protein A (TIFA)-dependent cytosolic surveillance pathway, which senses the bacterial metabolite heptose-1,7-bisphosphate (HBP), functions after NOD1 to detect bacteria replicating free in the host cytosol. Whereas NOD1 mediated a transient burst of NF-κB activation during bacterial entry, TIFA sensed HBP released during bacterial replication, assembling into large signaling complexes to drive a dynamic inflammatory response that reflected the rate of intracellular bacterial proliferation. Strikingly, IECs lacking TIFA were unable to discriminate between proliferating and stagnant intracellular bacteria, despite the NOD1/2 pathways being intact. Our results define TIFA as a rheostat for intracellular bacterial replication, escalating the immune response to invasive Gram-negative bacteria that exploit the host cytosol for growth.
Charles Moureu : du Collège de France aux gaz de combat (2015)

Les sentiments patriotique et nationaliste s’en trouvent exacerbés et jouent un rôle essentiel dans leurs choix professionnels et politiques. Si je m’attarde sur Charles Moureu, c’est en effet qu’il fut l’unique professeur nommé au Collège de France pendant les quatre ans du conflit. Ce sera en 1917, il avait 54 ans, sur la prestigieuse chaire de Chimie organique, succédant à Émile Jungfleisch lui-même successeur de Marcellin Berthelot. Il le méritait. Chimiste organicien de synthèse, élu à l...
Beneficial effect of recombinant rC1rC2 collagenases on human islet function: Efficacy of low-dose enzymes on pancreas digestion and yield (2017)

A high number of human islets can be isolated by using modern purified tissue dissociation enzymes; however, this requires the use of >20 Wunsch units (WU)/g of pancreas for digestion. Attempts to reduce this dose have resulted in pancreas underdigestion and poor islet recovery but improved islet function. In this study, we achieved a high number of functional islets using a low dose of recombinant collagenase enzyme mixture (RCEM-1200 WU rC2 and 10 million collagen-degrading activity [CDA] U of rC1 containing about 209 mg of collagenase to digest a 100-g pancreas). The collagenase dose used in these isolations is about 42% of the natural collagenase enzyme mixture (NCEM) dose commonly used to digest a 100-g pancreas. Low-dose RCEM was efficient in digesting entire pancreases to obtain higher yield (5535 ± 830 and 2582 ± 925 islet equivalent/g, P < .05) and less undigested tissue (16.7 ± 5% and 37.8 ± 3%, P < .05) compared with low-dose NCEM (12WU/g). Additionally, low-dose RCEM islets retained better morphology (confirmed with scanning electron microscopy) and higher in vitro basal insulin release (2391 ± 1342 and 1778 ± 978 μU/mL; P < .05) compared with standard-dose NCEM. Nude mouse bioassay demonstrated better islet function for low-dose RCEM (area under the curve [AUC] 24 968) compared with low-dose (AUC-38 225) or standard-dose NCEM (AUC-38 685), P < .05. This is the first report indicating that islet function can be improved by using low-dose rC1rC2 (RCEM).
Dynamic file-access characteristics of a production parallel scientific workload (1994)

Multiprocessors have permitted astounding increases in computational performance, but many cannot meet the intense I/O requirements of some scientific applications. An important component of any solution to this I/O bottleneck is a parallel file system that can provide high-bandwidth access to tremendous amounts of data in parallel to hundreds or thousands of processors.Most successful systems are based on a solid understanding of the expected workload, but thus far there have been no comprehensive workload characterizations of multiprocessor file systems. This paper presents the results of a three week tracing study in which all file-related activity on a massively parallel computer was recorded. Our instrumentation differs from previous efforts in that it collects information about every I/O request and about the mix of jobs running in a production environment. We also present the results of a trace-driven caching simulation and recommendations for designers of multiprocessor file systems.
Solid-phase synthesis and biological evaluation of piperazine-based novel bacterial topoisomerase inhibitors (2021)

There is an emerging global need for new and more effective antibiotics against multi-resistant bacteria. This situation has led to massive industrial investigations on novel bacterial topoisomerase inhibitors (NBTIs) that target the vital bacterial enzymes DNA gyrase and topoisomerase IV. However, several of the NBTI compound classes have been associated with inhibition of the hERG potassium channel, an undesired cause of cardiac arrhythmia, which challenges medicinal chemistry efforts through lengthy synthetic routes. We herein present a solid-phase strategy that rapidly facilitates the chemical synthesis of a promising new class of NBTIs. A proof-of-concept library was synthesized with the ability to modulate both hERG affinity and antibacterial activity through scaffold substitutions.
Acute Hemostasis During Laparoscopic Procedures: Method for Intraoperative Application of Hemostatic Material (1994)

No AccessJournal of UrologyUrologists at Work1 Jan 1994Acute Hemostasis During Laparoscopic Procedures: Method for Intraoperative Application of Hemostatic Material Kurt Kerbl and Ralph V. Clayman Kurt KerblKurt Kerbl More articles by this author and Ralph V. ClaymanRalph V. Clayman More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)34883-8AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Acute Hemostasis During Laparoscopic Procedures: Method for Intraoperative Application of Hemostatic Material." The Journal of Urology, 151(1), pp. 109–110 © 1994 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 151Issue 1January 1994Page: 109-110 Advertisement Copyright & Permissions© 1994 by The American Urological Association Education and Research, Inc.KeywordsperitoneoscopyhemostasishemorrhageMetricsAuthor Information Kurt Kerbl More articles by this author Ralph V. Clayman More articles by this author Expand All Advertisement PDF downloadLoading ...
Taking Search to Task (2023)

The importance of tasks in information retrieval (IR) has been long argued for, addressed in different ways, often ignored, and frequently revisited. For decades, scholars made a case for the role that a user’s task plays in how and why that user engages in search and what a search system should do to assist. But for the most part, the IR community has been too focused on query processing and assuming a search task to be a collection of user queries, often ignoring if or how such an assumption addresses the users accomplishing their tasks. With emerging areas of conversational agents and proactive IR, understanding and addressing users’ tasks has become more important than ever before. In this paper, we provide various perspectives on where the state-of-the-art is with regard to tasks in IR, what are some of the bottlenecks in deriving and using task information, and how do we go forward from here. In addition to covering relevant literature, the paper provides a synthesis of historical and current perspectives on understanding, extracting, and addressing task-focused search. To ground ongoing and future research in this area, we present a new framing device for tasks using a tree-like structure and various moves on that structure that allow different interpretations and applications. Presented as a combination of synthesis of ideas and past works, proposals for future research, and our perspectives on technical, social, and ethical considerations, this paper is meant to help revitalize the interest and future work in task-based IR.
Measurement of VH, $$ \mathrm{H}\to \mathrm{b}\overline{\mathrm{b}} $$ production as a function of the vector-boson transverse momentum in 13 TeV pp collisions with the ATLAS detector (2019)

A bstract Cross-sections of associated production of a Higgs boson decaying into bottomquark pairs and an electroweak gauge boson, W or Z , decaying into leptons are measured as a function of the gauge boson transverse momentum. The measurements are performed in kinematic fiducial volumes defined in the ‘simplified template cross-section’ framework. The results are obtained using 79.8 fb −1 of proton-proton collisions recorded by the ATLAS detector at the Large Hadron Collider at a centre-of-mass energy of 13 TeV. All measurements are found to be in agreement with the Standard Model predictions, and limits are set on the parameters of an effective Lagrangian sensitive to modifications of the Higgs boson couplings to the electroweak gauge bosons.
The NH2-terminal domain of Escherichia coli ribosomal protein L11. Its three-dimensional location and its role in the binding of release factors 1 and 2. (1984)

Ribosomes from three previously described mutants of Escherichia coli lacking L11 ( AM68 , AM76 , and AM77 ) supported in vitro termination with release factor 1 very poorly, but with release factor 2 had a severalfold elevation in activity for this function compared with ribosomes from a control strain or from a mutant containing unmethylated L11. L11 exerts its effect on the binding of the factors into a functional ribosomal complex with the termination codon. Reconstitution of L11 back into the L11-lacking ribosomes restored them to the control phenotype. The NH2-terminal part of L11 (amino acids 1-64) seems critical in modulating release factor binding. This part of L11 has been localized with the use of fragment-specific antibodies on the three-dimensional model of the 50 S subunit in the region from where the L7/L12 stalk originates. IgG antibodies from an antiserum specific for this fragment but not a middle fragment of L11 (amino acids 65-102) strongly inhibited in vitro termination. The activities of the two factors were inhibited differentially by several anti-L11 preparations recognizing antigenic determinants in the NH2-terminal part of L11. In all but one case, release factor 1 was more sensitive. These studies indicate that there are significant differences in the binding domains for the two release factors which are affected by the NH2-terminal part of L11.
Stable Consensus Decision Making for Spatially Distributed Multiagent Systems with Multiple Leaders (2020)

This paper considers the consensus decision-making problem of spatially distributed multiagent systems with multiple leaders, where the leaders have the preference about the destination, while the followers have no such preference. The agents have limited capability to sense the movement information of their local neighbors determined via the spatial relative distance, and make movement decisions accordingly. The objective is to guide the followers to move with the same preferred direction as leaders have (i.e., reaching a stable consensus). We provide detailed analysis for the information transfer between the subgroups of leaders and followers, and establish quantitative results on the proportion of leaders needed to reach the stable consensus for two cases: leaders with the same preference and leaders with different preferences. For the system where the leaders have the same preference, we provide an upper bound (impossibility theorem) and a lower bound (sufficient condition) for the proportion of leaders needed in reaching the stable consensus. When the leaders have two different preferences, we provide a sufficient condition and a necessary condition on the proportions of two subgroups of leaders to achieve stable consensus decisions.
The economics of uncomplicated mitral valve surgery. (1997)

These data suggest that, beyond the recognized benefits of MV reconstruction, namely preservation of LV function and avoidance of long-term anticoagulation, there is an economic advantage to MV reconstruction for patients and payors, even in uncomplicated cases. These differences may become more apparent with longer follow-up and in patients having poor function or combined procedures. This finding reinforces the idea that MV reconstruction is the option of choice for patients with mitral regurgitation.
A bias-reducing strategy in profiling small RNAs using Solexa (2011)

Small RNAs (smRNAs) encompass several different classes of short noncoding RNAs. Progress in smRNA research and applications has coincided with the advance of techniques to detect them. Next-generation sequencing technologies are becoming the preferred smRNA profiling method because of their high-throughput capacity and digitized results. In our small RNA profiling study using Solexa, we observed serious biases introduced by the 5' adaptors in small RNA species coverage and abundance; therefore, the results cannot reveal the accurate composition of the small RNAome. We found that the profiling results can be significantly optimized by using an index pool of 64 customized 5' adaptors. This pool of 64 adaptors can be further reduced to four smaller index pools, each containing 16 adaptors, to minimize profiling bias and facilitate multiplexing. It is plausible that this type of bias exists in other deep-sequencing technologies, and adaptor pooling could be an easy work-around solution to reveal the "true" small RNAome.
Thermal rearrangements of spiro[2.3]hex-4-enes and spiro[2.3]hexadienes (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThermal rearrangements of spiro[2.3]hex-4-enes and spiro[2.3]hexadienesM. F. Semmelhack and R. J. De FrancoCite this: J. Am. Chem. Soc. 1972, 94, 6, 2116–2118Publication Date (Print):March 1, 1972Publication History Published online1 May 2002Published inissue 1 March 1972https://doi.org/10.1021/ja00761a056RIGHTS & PERMISSIONSArticle Views58Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (388 KB) Get e-Alerts Get e-Alerts
Dynamic diversity of synthetic supramolecular polymers in water as revealed by hydrogen/deuterium exchange (2017)

Numerous self-assembling molecules have been synthesized aiming at mimicking both the structural and dynamic properties found in living systems. Here we show the application of hydrogen/deuterium exchange (HDX) mass spectrometry (MS) to unravel the nanoscale organization and the structural dynamics of synthetic supramolecular polymers in water. We select benzene-1,3,5-tricarboxamide (BTA) derivatives that self-assemble in H<sub>2</sub>O to illustrate the strength of this technique for supramolecular polymers. The BTA structure has six exchangeable hydrogen atoms and we follow their exchange as a function of time after diluting the H<sub>2</sub>O solution with a 100-fold excess of D<sub>2</sub>O. The kinetic H/D exchange profiles reveal that these supramolecular polymers in water are dynamically diverse; a notion that has previously not been observed using other techniques. In addition, we report that small changes in the molecular structure can be used to control the dynamics of synthetic supramolecular polymers in water.
Radioimmunoassay for pantothenic acid in blood and other tissues. [/sup 3/H and /sup 14/C tracer techniques] (1979)

We described a radioimmunoassay for pantothenic acid in biological tissues. D-Pantothenic acid was conjugated with bovine serum albumin by use of a bromoacetyl derivative of pantothenic acid, and antibody to this antigen was raised by injecting it into the foot pads of rabbits. For the radioimmunoassay, a 100-fold dilution of the resulting antiserum was incubated with radiolabeled panthothentic acid. The antibodies were precipitated and dissolved, and the radioactivity of the solution was measured in a liquid scintillation counter. Between 5 and 125 ng of pantothenic acid can be detected in 75 ..mu..L of tissue extract. Validation included recovery and precision studies, parallelism with tissue extracts, and competitive binding studies. Results of the radioimmunoassay and those of microbiological assay with use of Lactobacillus plantarum correlated well (r = 0.80).