gebhart/patrepeval huggingface dataset:
High-sensitivity permeation measurements on flexible OLED substrates (2004)

We describe a novel method to measure permeation rates for oxidizing agents with very high sensitivity. The technique is based on monitoring the resistance of a degrading Ca sensor <i>in situ</i>, inside a climate chamber. A sensitivity limit below 10<sup>-6</sup> g/m<sup>2</sup> day is reported for accelerated measurement conditions of 38&deg;C and 90% relative humidity. The benefits of the method are demonstrated for single- and double-sided barrier foils, and the temperature and humidity dependence of the transport through PET is analyzed in detail. The method is also applied to obtain permeation rates for a barrier-coated substrate after as well as during bending. Theoretical simulations are used to evaluate the influence of a defect-dominated transport mechanism on the experimental results and to model the time evolution of the concentration profile in a double-barrier stack. Implications for the development of barrier-enhanced substrates for flexible OLED applications are discussed.
Dielectric grating evanescent reflectors in double-mode fibers (1986)

Grating reflectors are interesting as narrowband filters for optical fiber wavelength-division multiplexing. In particular, gratings directly in the evanescent field of a guided mode offer possibilities for all-fiber in-line components. Previously, evanescent grating reflectors have been demonstrated with single-mode fibers. 1 Although efficient reflection appears possible, single-mode reflectors have the disadvantage of needing an element such as a directional coupler to extract the reflected signal returning on the same fiber. The problem is that the forward signal is also split by the coupler. Such an arrangement incurs a minimum of 6-dB loss to the extracted reflected signal.
Discovery of Novel 2-((Pyridin-3-yloxy)methyl)piperazines as α7 Nicotinic Acetylcholine Receptor Modulators for the Treatment of Inflammatory Disorders (2014)

Herein we report the design, synthesis, and structure-activity relationships for a new class of α7 nicotinic acetylcholine receptor (nAChR) modulators based on the 2-((pyridin-3-yloxy)methyl)piperazine scaffold. The oxazolo[4,5-b]pyridine, (R)-18, and 4-methoxyphenylurea, (R)-47, were identified as potent and selective modulators of the α7 nAChR with favorable in vitro safety profiles and good oral bioavailability in mouse. Both compounds were shown to significantly inhibit cellular infiltration in a murine model of allergic lung inflammation. Despite the structural and in vivo functional similarities in the compounds, only (R)-18 was shown to be an agonist. Compound (R)-47 demonstrated silent agonist activity. These data support the hypothesis that the anti-inflammatory activity of the α7 nAChR is mediated by a signal transduction pathway that is independent of ion current.
HLADR: A Database System for Enhancing the Discovery of Biomarkers for Predicting Human Leukocyte Antigen-Mediated Idiosyncratic Adverse Drug Reactions (2015)

Constructing studies with samples from homogeneous ethnic groups and identifying cofactors that affect negative predictive values and positive predictive values will become necessary to enhance the predictability of HLA biomarkers for future research on IDRs.
Selective Catalytic Oxidation of Unprotected Carbohydrates (2016)

The development of new strategies for the direct catalytic functionalization of unprotected carbohydrates would be an enabling advance for glycoscience. Herein we report that the catalytic oxidation of unprotected carbohydrates can be carried out selectively with [(neocuproine)Pd(OAc)]2(OTf)2 (1) to generate the 3-ketoses. Catalytic aerobic oxidation can be carried out with Pd loadings as low as 1% in the presence of phenolic additives. Catalytic oxidation of a variety of unprotected pyranosides in acetonitrile or acetonitrile/water with Pd catalyst 1 with either oxygen or benzoquinone selectively generates the 3-ketoses. Minor amounts of the 4-ketoses are formed competitively, particularly in the case of pyranosides bearing axial substituents at C4 of the pyranoside. Catalytic oxidations can also be carried out in trifluorethanol, but for pyranosides bearing axial substituents at C2 or C4, selective oxidation to the 3-ketose is accompanied by epimerization to afford the equatorial 3-ketoses. Catalytic oxidation of unprotected hexafuranosides or sialic acid derivatives occurs selectively at the exocyclic diol or triol in trifluoroethanol to generate exocyclic hydroxyketones.
Re: A Gene Signature Identified Using a Mouse Model of Androgen Receptor-Dependent Prostate Cancer Predicts Biochemical Relapse in Human Disease (2013)

No AccessJournal of UrologyInvestigative Urology1 May 2013Re: A Gene Signature Identified Using a Mouse Model of Androgen Receptor-Dependent Prostate Cancer Predicts Biochemical Relapse in Human Disease Anthony AtalaM.D. Anthony AtalaAnthony Atala More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.01.066AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Re: A Gene Signature Identified Using a Mouse Model of Androgen Receptor-Dependent Prostate Cancer Predicts Biochemical Relapse in Human Disease." The Journal of Urology, 189(5), p. 1990 © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 5May 2013Page: 1990 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Anthony Atala More articles by this author Expand All Advertisement PDF downloadLoading ...
Glenohumeral Arthrosis in Anterior Instability before and after Surgical Treatment (2004)

Similar factors contribute to preoperative and postoperative arthritis in patients with anterior glenohumeral instability, suggesting that surgery does not influence the risk factors of arthritis. Although decreased external rotation with the arm at side statistically correlated with arthritis in this study, the authors were unable to establish this as an effectual relationship because nearly all patients with glenohumeral osteoarthritis, whether instability related or not, have decreased external rotation.
Zipper : a duplex scheme for VDSL based on DMT (1997)

A duplex scheme for DMT-based VDSL systems is presented here. It offers a solution to the problem with NEXT and near-echoes in broadband communications. The scheme has high duplex efficiency, low latency, and attractive transmit power features. However, hardware verification remains.
Measurement-Based Indoor Millimeter Wave Blockage Models (2022)

Blockage is a substantial problem at millimeter wave (mmWave) frequencies, much more so than sub-6 GHz. Blockage events caused by objects such as cars and humans occur quickly and have substantial attenuation; typical attenuations in this work range from 11 to 22 dB, with a maximum of 32 dB. This problem is overcome with spatial diversity. During blockage events, mmWave transceivers can beamform towards an unblocked path. In this paper we explore this idea in depth: if the primary path is blocked, which alternate paths will be available? To answer this question, we have built a measurement system that uses 60 GHz phased arrays to rapidly obtain spatially resolved measurements of the channel. Scans are repeated every 3.2 ms, allowing us to observe blockage events that occur on the different paths in the channel. The design of this system is presented, and a description is given of three human-body blockage measurement campaigns. Paths are assigned states of blocked/unblocked, and each measurement is expressed as a time series of states which specify the status of each path. The evolution between states is described with a Markov model, and the measurement results are used to derive transition probabilities between states.
A binocular CMOS range image sensor with bit-serial block-parallel interface using cyclic pipelined ADCs (2003)

A binocular CMOS image sensor used with a pair of aligned-in-parallel optical systems for range imaging is implemented. Sixteen compact cyclic pipelined analog-to-digital converters are integrated per an image sensor. The dedicated processor starts 16/spl times/16 FFT when the first bit-serial block-parallel data is obtained. The image sensor produces a 16/spl times/16 range image from a pair of 256/spl times/256 images, together with the dedicated pipelined FFT processor, at the maximum pipeline performance.
20 Tbit/s Transmission Over 6860 km With Sub-Nyquist Channel Spacing (2011)

We demonstrate that channel spacing can be reduced to values smaller than the Nyquist channel spacing over transoceanic distance. Modulation memory induced by constrained transmitter bandwidth together with multisymbol detection can reduce intersymbol interference for systems with sub-Nyquist channel spacing. We transmit 198 × 100 G bandwidth constrained polarization-division-multiplexed return-to-zero quaternary phase shift keying channels with 400% spectral efficiency over 6860 km using 52 km spans of 150 μ m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> fiber and simple single-stage erbium-doped fiber amplifiers without any Raman amplification. We also show that 100 G coherent nonlinear performance scales differently with distance on uncompensated dispersion maps compared with direct detection transmission.
A six degree of freedom micromanipulator for ophthalmic surgery (2002)

Needs which have arisen in ophthalmic research have motivated the development of a six-degree-of-freedom parallel micromanipulator. The first application of the tool will be in the treatment of retinal venous occlusion, for which micron-scale spherical movement of a glass micropipette tip inside the eye is required. The initial operation mode will be open loop, while future operation will be in a force-reflecting bilateral (macro-master/micro-slave) arrangement. Presented here are some of the design criteria, the mathematical tools used in evaluating various parallel manipulator designs, and the final kinematic configuration.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Acoustic radiation force for rapid detection of particles in biological liquids (2011)

As known, ultrasonic standing waves can be used to concentrate particles and biological cells into separated bands. Acoustical separation based on plane standing waves is limited to particles of few microns and larger. This presentation concerns using acoustic radiation force (ARF) produced by cylindrical standing waves for detection of high-density submicron-size particles (bacterial cells) in pressure nodes and low-density particles (fat globules) in antinodes. Theoretical calculations show that in a cylindrical ultrasonic chamber, ARF near the central node can exceed the force at the chamber periphery by about 20 times. In a cylindrical standing wave, ARF may induce movement of bacteria with a speed of the order of a few millimeter per second at a frequency of 2 MHz and pressure amplitude of 100 kPa, whereas the speed of bacteria in plane standing wave does not exceed 0.2 mm/s under the same conditions. The cylindrical standing wave system performance was tested for the E. coli bacteria in water and for a multi-component system containing fat globules and somatic cells in milk. Dilute suspensions of bacteria or fat globules were concentrated by at least 2 orders of magnitude.
Understanding and Improving Information Extraction From Online Geospatial Data Visualizations for Screen-Reader Users (2022)

Prior work has studied the interaction experiences of screen-reader users with simple online data visualizations (e.g., bar charts, line graphs, scatter plots), highlighting the disenfranchisement of screen-reader users in accessing information from these visualizations. However, the interactions of screen-reader users with online geospatial data visualizations, commonly used by visualization creators to represent geospatial data (e.g., COVID-19 cases per US state), remain unexplored. In this work, we study the interactions of and information extraction by screen-reader users from online geospatial data visualizations. Specifically, we conducted a user study with 12 screen-reader users to understand the information they seek from online geospatial data visualizations and the questions they ask to extract that information. We utilized our findings to generate a taxonomy of information sought from our participants’ interactions. Additionally, we extended the functionalities of VoxLens—an open-source multi-modal solution that improves data visualization accessibility—to enable screen-reader users to extract information from online geospatial data visualizations.
Germline loss-of-function PAM variants are enriched in subjects with pituitary hypersecretion (2023)

The identification of PAM as a candidate gene associated with pituitary hypersecretion opens the possibility of developing novel therapeutics based on altering PAM function.
A 0.5V 74dB SNDR 25kHz CT /spl Delta//spl Sigma/ Modulator with Return-to-Open DAC (2006)

A 0.5V 3rd-order 1b fully differential CT ΔΣ modulator in a 0.18μm CMOS process is presented. A special return-to-open DAC, a body-input gate-clocked comparator, and body-input OTAs for the active-RC loop filter enable the ultra-low voltage operation. The 0.6mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> chip consumes 370μW and achieves a peak SNDR of 74dB in a 25kHz BW
Dysplay-Special Contribution from IWD'02-A 16-cm Dual Neck Diameter, Integrated Component, Projection CRT (2003)

A 16cm, ∅29.1mm compatible projection CRT, integrated component system has been developed utilizing an LD-Hi-UPF electron gun with an effective focusing lens of 21mm. This was achieved with a dual diameter neck (∅29.1-36.5mm) integrated component design. The current ∅29.1mm projection CRT deflection power was maintained while reducing the 5% center beam spot profile size by 20% (2mA optimum focus). The integrated components were optimized to provide the system with improved corner focus. This CRT delivers superior image quality and is compatible with current ∅29.1mm neck CRTs in rear projection systems.
Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes (2010)

The actin cytoskeleton is essential for proper functioning of the immune system by regulating cell movement, cell-cell interactions, cell signaling, and cell division.The Wiskott-Aldrich syndrome protein (WASP) is uniquely expressed in hematopoietic cells and is a key organizer of cell shape through coordination of receptor signaling to remodeling of the actin cytoskeleton.WASP is critically dependent on its structural conformation and is thought to reside in an inactive form in the cytoplasm caused by an intramolecular interaction between the GTPase binding domain and the C-terminal verprolin-cofilin-acidic domain (Kim et al., 2000).Binding of WASP-interacting proteins such as Cdc42 and Nck can release this autoinhibition, exposing the verprolin-cofilin-acidic domain to the Arp2/3 complex and globular actin, and inducing actin polymerization.WASP deficiency affects the immune system broadly, and WAS patients suffer from immunodeficiency, thrombocytopenia, and
Large-eddy simulation and modelling of dissolved oxygen transport and depletion in water bodies (2012)

Thesis (Ph.D, Mechanical and Materials Engineering) -- Queen's University, 2012-07-04 11:13:24.936
A 256mb synchronous-burst DDR SRAM with hierarchical bit-line architecture for mobile applications (2005)

RZ current switches are added to a current steering DAC for high-frequency wideband applications to achieve 800MHz bandwidth at 1/sup st/ and 2/sup nd/ Nyquist band without the need for a reverse sinc equalization filter. Implemented in a GaAs HBT process with 4.5 /spl mu/m/sup 2/ minimum emitter area, the DAC dissipates 1.2W at -5V with a 1.6GHz clock and 0dBm typical output power.
The Relation of Eye Gaze and Face Pose (2014)

We are interested in using context to improve speech recognition and speech understanding. Knowing what the user is attending to visually helps us predict their utterances and thus makes speech recognition easier. Eye gaze is one way to access this signal, but is often unavailable (or expensive to gather) at longer distances. In this paper we look at joint eye-gaze and facial-pose information while users perform a speech reading task. We hypothesize, and verify experimentally, that the eyes lead, and then the face follows. Face pose might not be as fast, or as accurate a signal of visual attention as eye gaze, but based on experiments correlating eye gaze with speech recognition, we conclude that face pose provides useful information to bias a recognizer toward higher accuracy.
Dose-Intensive Melphalan With Blood Stem-Cell Support for the Treatment of AL (Amyloid Light-Chain) Amyloidosis: Survival and Responses in 25 Patients (1998)

AL (amyloid light-chain) amyloidosis is an uncommon plasma cell disorder in which depositions of amyloid light-chain protein cause progressive organ failure and death in a median of 13 months. Autologous stem-cell transplantation is effective therapy for multiple myeloma and therefore, we evaluated its efficacy for AL amyloidosis. Patients with adequate cardiac, pulmonary, and renal function had stem cells mobilized with granulocyte-colony stimulating factor and were treated with dose-intensive intravenous melphalan (200 mg/m2). Response to therapy was determined by survival and improvement of performance status, complete response or persistence of the clonal plasma cell disorder, and change in the function of organs involved with amyloid at baseline. We enrolled 25 patients with a median age of 48 years (range, 29-60), all of whom had biopsy-proven amyloidosis with clonal plasma cell disorders. Twenty-two (88%) were Southwest Oncology Group performance status 1 or 2 within a year of diagnosis, and 16 (64%) had received no prior therapy. Predominant amyloid-related organ involvement was cardiac (n = 8), renal (n = 7), hepatic (n = 6), neuropathic (n = 3), and lymphatic (n = 1). Fifteen patients had one or two organ systems involved, whereas 10 had three or more involved. With a median follow-up of 24 months (12-38), 17 of 25 patients (68%) are alive, and the median survival has not been reached. Thirteen of 21 patients (62%) evaluated 3 months posttransplant had complete responses of their clonal plasma cell disorders. Currently, two thirds of the surviving patients (11 of 17) have experienced improvements of amyloid-related organ involvement in all systems, whereas 4 of 17 have stable disease. The improvement in the median performance status of the 17 survivors at follow-up (0 [range, 0-3]) is statistically significant versus baseline (2 [range, 1-3]; P &lt; .01). Significant negative prognostic factors with respect to overall survival include amyloid involvement of more than two major organ systems and predominant cardiac involvement. Three patients have experienced relapses of the clonal plasma cell disorder at 12 and 24 months. Dose-intensive therapy should currently be considered as the preferred therapy for patients with AL amyloidosis who meet functional criteria for autologous transplantation.
New approach to isolation and characterization of uncultured microorganisms (2004)

大多数の微生物が分離培養困難であることはもはや多くの微生物研究者が認識しているところである。さまざまな分子遺伝学的手法を用いて複雑系の微生物の横顔を垣間見ることができるようになったものの,依然その機能を推定することは困難な作業を伴う。それでもなお,いかにこれらの微生物を捕捉するかが,今後の大きな課題であると言えよう。環境ゲノム解析という培養を経ない手法が新たな潮流として芽生えつつある中,微生物間相互作用や共生という観点で微生物をとらえ直すことによって新たな分離培養アプローチが生まれる可能性がある。
Oxygen storage capacity of alumina-supported Rh/CeO2 catalyst. (1990)

アルミナ担持セリアーロジウム触媒の可逆的酸素跡蔵能力(Oxygen Storage Capacity ; OSC)を測定し,アルミナ担持セリア触媒とアルミナ担持ロジウム触媒を物理的に混合したもののOSCと比較検討した。その結果,セリア単位モルあたりのOSCは,薗者の方がいちじるしく大きいことがわかった。これは,前者ではアルミナ上に分散したセ,リアとロジウムが密接しているのに対し,後者ではセリアとロジウムがそれぞれ別々に存在しているためである。セリア系触媒のOSCを増加させるためには,セリアと貴金属粒子間の密な接触が必要不可欠であることが判明した。
An EPR study on the enantioselective aziridination properties of a CuNaY zeolite (2001)

A CuNaY catalyst was prepared and used to study the enantioselective aziridination of styrene, with PhINTs as the nitrogen source, in the presence of a bis(oxazoline) chiral modifier. The chiral modifier used was a diimine ligand, (S)-(−)-2,2′-isopropylidenebis(4-phenyl-2-oxazoline). EPR spectroscopy provides the first direct experimental evidence for the formation of a copper(II)-bis(oxazoline) complex inside the Y zeolite pores after stirring the calcined catalysts with the chiral ligand using acetonitrile as solvent. The copper complexes possess square pyramidal and square planar symmetries, with spin Hamiltonian parameters analogous to those of the equivalent homogeneous complex dissolved in solution. These copper(II) complexes accounted for at least 40% of all available copper within the ion exchanged CuNaY catalyst and represent one Cu(II)-bis(oxazoline) complex per supercage. The remaining uncomplexed Cu(II) ions remain solvated to the acetonitrile molecules. After the aziridination reaction was carried out in the presence of styrene and PhINTs, EPR evidenced the selective loss of the signal due to the copper(II)-bis(oxazoline) complex with square pyramidal and square planar symmetries but practically no loss in overall Cu(II) content. This was explained on the grounds of a changing co-ordination environment of the encapsulated complex. However when PhINTs was added separately to the catalyst a dramatic loss in Cu(II) signal intensity was observed. These results are discussed in terms of the reaction mechanism in operation.
Change in Muscle Synergies During Stairmill Ascent With External Forces on the Pelvis (2022)

Stair ascent is a challenging daily task that requires fine muscle coordination to complete the task while avoiding falls. However, there is little information on training paradigms that could improve stair ascent. This study investigates how external forces applied on the pelvis in different directions and different magnitudes affect the muscle coordination during stairmill ascent. We used a Tethered Pelvic Assist Device (TPAD) to apply external forces on the pelvis during continuous ascent on a stairmill. Ten young healthy subjects participated in sessions where external forces were applied on the pelvis laterally, vertically, forward, and along the incline of the stairmill. Each session was over a duration of two minutes with force magnitudes starting from 0% body weight (BW). The applied force was held constant and increased by 5% BW every 30 seconds up to 15% BW. Muscle activation signals from fifteen muscles were measured and the structure of muscle synergy was calculated under these altered forces. The results show five muscle synergies during the stair ascent motion. We found that vertical and forward external forces on the pelvis affected the quadriceps group during knee extension. Additionally, the muscle activation timings of the thigh and back shank muscles were significantly different during different force conditions. These findings provide insights into muscle responses when external forces are applied on the pelvis in different directions and magnitudes. These results may help clinicians and physical therapists to design customized rehabilitation strategies to suit patient needs to improve performance during stair climbing.
Červená kniha květeny jižní části Čech (2013)

The book summarises data about ecology, biology, threats and conservation possibilities of 830 vascular plant species and subspecies which are threatened, extinct, missing or potentially threatened (documented by insufficient data) in southern part of Bohemia. Detailed analysis of historical as well as of recent distribution in study area is included for each species. The distribution of majority of the taxa is illustrated by distribution maps. The texts are accompanied by photos of selected species.