gebhart/patrepeval huggingface dataset:
Thermosome: A Group II Chaperonin of Archaea (2016)

Abstract Chaperonin, heat shock protein 60, plays an important role in the proteostasis of cytosol. Chaperonins are divided into two groups: group I and group II. Group II chaperonins exist in eukaryotes and archaea, and these chaperonins are named CCT/TRiC and Thermosome, respectively. Group II chaperonins have almost the same structure as group I chaperonins. The main difference is the existence of a helical protrusion, which constitutes a built‐in lid of the cavity. Group II chaperonin captures an unfolded protein in the cavity in the open conformation and changes to the closed conformation in an ATP‐dependent manner, which triggers folding of the captured protein. As Thermosome is relatively stable and simple compared with CCT, the conformational change mechanism and also the interaction with co‐chaperone, Prefoldin, have been studied in detail using Thermosome. The conformational change procedure of Thermosome will give insights on protein folding mechanism by group II chaperonins. Key Concepts Group II chaperonin is an essential cytosolic molecular chaperone in eukaryotes and archaea. The archaeal group II chaperonin is named Thermosome. Group II chaperonin has a built‐in lid for the central cavity. As ATP induces a conformational change from the open to the closed conformation, twisting of the ring occurs. Group II chaperonin cooperates with a co‐chaperone, Prefoldin, which captures an unfolded protein and transfers it to the central cavity of the group II chaperonin.
Lack of immunogenicity of xenogeneic DNA from porcine biomaterials (2022)

The immunological safety of porcine extracellular matrix biomaterials appears not to be related to DNA residues present. Such biomaterials need not be extensively processed, likely leading to detrimental changes in their bioactivity, solely in an effort to remove the mammalian DNA.
Visible Light Communications: A Novel Indoor Network Planning Approach (2021)

We propose a Partition-based Visibility (PV) graph modeling to find the minimum number of Visible Light Communications (VLC) nodes and their locations for reliable indoor coverage. VLC network offers a low-cost technology on a license-free spectrum to complement the contemporary mobile network services offered on Radio Frequency (RF) bands. However, VLC suffers from propagation limits: Firstly, in presence of opaque obstacles such as walls, doors, and even curtains, strong link blockage is experienced as the power of reflections is much weaker than the power of the Line-of-Sight (LoS) link. Secondly, the received optical power at users drops as the angle of irradiance between a LED lamp and the user increases, imposing a range constraint on the VLC nodes. So, inspired by the Art Gallery Problem, we optimize the number and the locations of VLC nodes by characterizing the PV graph as a dual presentation of the floor plan and a Maximal Clique Clustering algorithm, which is able to solve not only the art gallery problem but also to extend the approach for the range constrained case.
Phenotypic plasticity of seed germination as a component of the complementary sets of adaptations and survival strategies during the life cycle of ephemerals occurring in the Negev Desert of Israel. (2003)

This paper discusses the effects on phenotypic plasticity of seed germination (PPSG) during seed development, maturation, dry storage and germination of ephemerals in the Negev Desert of Israel. In plant species occurring in the Negev Desert, daylength is one of the most important environmental factors that may affect seed germinability during the time of seed development and maturation on the mother plant. Thus, its effects on seed coat permeability to water, embryo germinability and seed germination are discussed. Different PPSG was found according to the seed position in the multi-seeded lignified dispersal units of various species. Strategies such as primary dormancy, thermodormancy and skotodormancy, which may prevent seed germination after a late rain near the beginning of the long, hot and dry summer, are important survival strategies found in plants occurring in the Negev. The gradual increase in air relative humidity and germination of hard seeds and temperature fluctuations as post-maturation strategies of hard seeds are discussed. Finally, bet-hedging germination as affected by the PPSG as well as the synaptospermic or serotinous strategies of seed release, dispersal and germination are also discussed.
Quantum photonics for computer security and other applications (2021)

The precise quantum control of single photons, together with the intrinsic advantage of being mobile make optical quantum system ideally suited for delegated quantum information tasks, reaching from well-established quantum cryptography to quantum clouds and quantum computer networks. Here I present that the exploit of quantum photonics allows for a variety of quantum-enhanced data security for quantum and classical computers. The latter is based on feasible hybrid classical-quantum technology, which shows promising new applications of readily available quantum photonics technology for complex data processing. As outlook I will discuss technological challenges for the scale up of photonic quantum computers, and our group’s current work for addressing some of those.
Collaborative Targeted Maximum Likelihood for Time to Event Data (2010)

Current methods used to analyze time to event data either rely on highly parametric assumptions which result in biased estimates of parameters which are purely chosen out of convenience, or are highly unstable because they ignore the global constraints of the true model. By using Targeted Maximum Likelihood Estimation (TMLE) one may consistently estimate parameters which directly answer the statistical question of interest. Targeted Maximum Likelihood Estimators are substitution estimators, which rely on estimating the underlying distribution. However, unlike other substitution estimators, the underlying distribution is estimated specifically to reduce bias in the estimate of the parameter of interest. We will present here an extension of TMLE for observational time to event data, the Collaborative Targeted Maximum Likelihood Estimator (C-TMLE) for the treatment specific survival curve. Through the use of a simulation study we will show that this method improves on commonly used methods in both robustness and efficiency. In fact, we will show that in certain situations the C-TMLE produces estimates whose mean square error is lower than the semi-parametric efficiency bound. We will also demonstrate that a semi-parametric efficient substitution estimator (TMLE) outperforms a semi-parametric efficient non-substitution estimator (the Augmented Inverse Probability Weighted estimator) in sparse data situations. Lastly, we will show that the bootstrap is able to produce valid 95 percent confidence intervals in sparse data situations, while influence curve based inference breaks down.
CMOS-Foundry Compatible, Broadband, and Compact Routing of Multimode SOI Waveguides (2023)

We demonstrate a CMOS-foundry compatible, broadband, and compact platform for routing multimode wavguides. Insertion loss of &lt;0.5dB and modal cross-talk of &lt;-15dB are measured for 90° and 180° R eff &lt; 3µm bends supporting over 200nm of bandwidth.
On-demand soundscape generation using spatial audio mixing (2011)

This paper proposes an on-demand soundscape generation and provisioning for a user to experience a real world in a requested remote place. This generation is achieved by spatial audio mixing considering a real world condition like geographical features or townscapes as well as dynamic situation such as town events or weather. The proposed velocity vector-based clustering can reduce the cost of composing/decomposing clusters of many sound sources.
Non-existence of a curve over 𝔽₃ of genus 5 with 14 rational points (1999)

We show that an absolutely irreducible, smooth, projective curve of genus <inline-formula content-type="math/mathml"> <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" alttext="5"> <mml:semantics> <mml:mn>5</mml:mn> <mml:annotation encoding="application/x-tex">5</mml:annotation> </mml:semantics> </mml:math> </inline-formula> over <inline-formula content-type="math/mathml"> <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" alttext="double-struck upper F 3"> <mml:semantics> <mml:msub> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:mi mathvariant="double-struck">F</mml:mi> </mml:mrow> <mml:mn>3</mml:mn> </mml:msub> <mml:annotation encoding="application/x-tex">\mathbb {F}_3</mml:annotation> </mml:semantics> </mml:math> </inline-formula> with <inline-formula content-type="math/mathml"> <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" alttext="14"> <mml:semantics> <mml:mn>14</mml:mn> <mml:annotation encoding="application/x-tex">14</mml:annotation> </mml:semantics> </mml:math> </inline-formula> rational points cannot exist.
A MEMS-relay for Power Applications (2007)

Contact travel and heat dissipation are important requirements of electrical power switching devices such as MEMS-relays and MEMS-switches. Whereas low-power MEMS-based RF switches have been vigorously studied, few studies have been reported on high-power MEMS-relays. This paper presents a MEMS-relay for power applications. The device is capable of make-break switching; has large contact travel, on the order of 10’s of μm; and has low contact resistance, on the order of 120 mΩ. Testing has demonstrated current carrying capacity on the order of several amperes and hot-switching of inductive loads, on the order of 10mH, without performance degradation.
Presentation of the SOCLE3 project and the STEEP lab (2010)

International audience
Bearing and Friction Design Capacity Software for Helical Anchors and Piles (2015)

Hubbell Power Systems, Inc./CHANCE®, in conjunction with Sailors Engineering, Inc. has updated its Helical Design Capacity Software. This latest version, “HeliCAP® v2.0”, is a state-of-the-art helical anchor and pile capacity program designed to operate in the Microsoft® environment. The program calculates the tension and compression capacity along with the frictional capacity, if applicable, of helical anchors and piles using design theories and methods adopted by the engineering staff at Hubbell Power Systems, Inc. This paper details the current state of practice employed by the software in the design methods and installation methodologies of helical anchors and piles.
BMET-26PHASE 2 STUDY OF VB-111, AN ANTI-CANCER GENE THERAPY, AS MONOTHERAPY FOLLOWED BY COMBINATION OF VB-111 WITH BEVACIZUMAB, IN PATIENTS WITH RECURRENT GLIOBLASTOMA (2015)

BACKGROUND: VB-111 is an anti-angiogenic agent consisting of a non-replicating adenovirus vector (Ad-5) with a modified murine pre-proendothelin promoter leading to apoptosis of tumor-vasculature by expressing a fas-chimera transgene in angiogenic-endothelial cells. Safety and efficacy of VB-111 alone and in combination with bevacizumab (BEV) were evaluated in recurrent-Glioblastoma (rGBM) patients in this Phase 1-2 dose-escalation study. METHODS: VB-111 was administered at 3x1012 or 1x1013 bimonthly until progression, followed by BEV standard-of-care (SOC). The protocol was amended to add-on BEV 10mg/Kg biweekly combined with VB-111 bimonthly, until further progression. Assessments included safety, pharmacokinetics, overall survival (OS) (Kaplan Meyer) and tumor response (RANO). RESULTS: 46 patients at 4 sites (US and Israel) received up to 13 doses of VB-111. Upon further progression, 24 received VB-111 with BEV, 22 were treated with BEV SOC. VB-111 was safe and well-tolerated alone and in combination with BEV. There were 30 grade ≥3 AEs, of which 6 were considered possibly related to VB-111: thrombocytopenia, pyrexia, brain edema, depressed consciousness, general weakness, pulmonary embolism. Median OS was 16 months for patients receiving combination therapy versus 8 months for those receiving SOC (p= 0.05). OS of combination therapy was superior to the historical control BELOB BEV arm, 16 versus 8 months (p = 0.003). Of 46 patients who received VB-111, 25 patients spiked a fever post-VB-111 dosing at least once, while 21 didn't. Feverish patients demonstrated a median OS of 16 months, compared to non-feverish patients, with a median OS of 8.5 months (p = 0.03). CONCLUSIONS: VB-111 was safe and well-tolerated alone and in combination with BEV in rGBM patients. OS of patients who received VB-111 followed by combination therapy almost doubled compared to historical BEV data, and compared to patients who received VB-111 monotherapy. Toxicities were as expected in this population. A phase 3 randomized controlled trial is currently underway.
High Average Power Frequency Conversion on the Mercury Laser (2006)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text A. J. Bayramian, R. J. Beach, C. Bibeau, R. Campbell, C. A. Ebbers, B. L. Freitas, R. Kent, D. Van Lue, Z. Liao, T. Ladran, S. A. Payne, K. I. Schaffers, S. Sutton, B. Chai, and Y. Fei, "High Average Power Frequency Conversion on the Mercury Laser," in Advanced Solid-State Photonics, Technical Digest (Optica Publishing Group, 2006), paper MB1. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Super Gas Barrier and Fire Resistance of Nanoplatelet/Nanofibril Multilayer Thin Films (2018)

Abstract Cellulose nanofibrils (CNF) are abundant in the fiber cell walls of many plants and are considered a nearly inexhaustible resource. With the goal of improving the flame resistance and gas barrier properties of cellulose‐based films, cationic CNF are assembled with anionic vermiculite (VMT) clay using the layer‐by‐layer deposition process. The highly aligned VMT nanoplatelets, together with cellulose nanofibrils, form a nanobrick wall structure that exhibits high optical transparency, flame resistance, super oxygen barrier, and high modulus. A 20 CNF/VMT bilayer (BL) nanocoating, with a thickness of only 136 nm, exhibits an oxygen transmission rate of 0.013 cc (m 2 day atm) –1 . With only 2 BL of CNF/VMT, the melting of flexible polyurethane foam exposed to a butane torch is prevented. These nanocoatings also exhibit a high elastic modulus (20 GPa) and hardness (1 GPa). This study demonstrates a unique, renewable, cellulose‐based nanocoating that could be used in a variety of packaging and protection applications.
Screening Methodology for the Efficient Pairing of Ionic Liquids and Carbonaceous Electrodes Applied to Electric Energy Storage (2013)

A model is presented that correlates the measured electric capacitance with the energy that comprises the desolvation, dissociation and adsorption energy of an ionic liquid into carbonaceous electrode (represented by single-wall carbon nanotubes). An original methodology is presented that allows for the calculation of the adsorption energy of ions in a host system that does not necessarily compensate the total charge of the adsorbed ions, leaving an overall net charge. To obtain overall negative (favorable) energies, adsorption energies need to overcome the energy cost for desolvation of the ion pair and its dissociation into individual ions. Smaller ions, such as BF4–, generally show larger dissociation energies than anions such as PF6– or TFSI–. Adsorption energies gradually increase with decreasing pore size of the CNT and show a maximum when the pore size is slightly greater than the dimensions of the adsorbed ion and the attractive van der Waals forces dominate the interaction. At smaller pore diameters, the adsorption energy sharply declines and becomes repulsive as a result of geometry deformations of the ion. Only for those diameters where the adsorption reaches maximum values is the adsorption energy sufficiently negative to balance the positive dissociation and desolvation energies. We present for each ion (and ionic liquid) what the most adequate electrode pore size should be for maximum capacitance.
Ring Opening Metathesis Polymerization Derived Polymers as Photoresists: Making Use of Thiol‐ene Chemistry (2011)

Ring opening metathesis polymerization derived poly(norbornene) films and aggregates were crosslinked via photo chemically induced thiol-ene chemistry using a multifunctional thiol and the double bonds present in the polymer backbones. The presented method was illustrated by the description of a negative-toned photoresist formulation based on above mentioned ingredients.
Textured digital elevation model formation from low-cost UAV LADAR/digital image data (2015)

Textured digital elevation models (TDEMs) have valuable use in precision agriculture, situational awareness, and disaster response. However, scientific-quality models are expensive to obtain using conventional aircraft-based methods. The cost of creating an accurate textured terrain model can be reduced by using a low-cost (&lt;$20k) UAV system fitted with ladar and electro-optical (EO) sensors. A texel camera fuses calibrated ladar and EO data upon simultaneous capture, creating a texel image. This eliminates the problem of fusing the data in a post-processing step and enables both 2D- and 3D-image registration techniques to be used. This paper describes formation of TDEMs using simulated data from a small UAV gathering swaths of texel images of the terrain below. Being a low-cost UAV, only a coarse knowledge of position and attitude is known, and thus both 2D- and 3D-image registration techniques must be used to register adjacent swaths of texel imagery to create a TDEM. The process of creating an aggregate texel image (a TDEM) from many smaller texel image swaths is described. The algorithm is seeded with the rough estimate of position and attitude of each capture. Details such as the required amount of texel image overlap, registration models, simulated flight patterns (level and turbulent), and texture image formation are presented. In addition, examples of such TDEMs are shown and analyzed for accuracy.
Dependence of the Growth Parameters on the In-Plane Distribution of 150 mm φ Size SiC Epitaxial Wafer (2014)

Silicon carbide (SiC) power devices are expected to be useful in low-loss power conversion equipment in wide-ranging industrial areas. 4H-SiC Schottky barrier diodes (SBDs) and metal oxide semiconductor field-effect transistors (MOSFETs) have been launched on the commercial market, and many results obtaining outstanding performance of 4H-SiC switching devices have been reported [1-. Presently, SiC chip cost is a big problem preventing an increase in market penetration of such commercial devices. Therefore, 150 mm size wafers are urgently required reducing the cost per unit area for SiC epitaxial layers. Recently, some SiC wafer vendors announced that 150 mm SiC substrate would be released [4, and some groups have reported results of epitaxial growth on 150 mm SiC substrate [6-9].
Measurements of fiducial cross-sections for $$t\bar{t}$$ t t ¯ production with one or two additional b-jets in pp collisions at $$\sqrt{s}$$ s =8 TeV using the ATLAS detector (2016)

Fiducial cross-sections for [Formula: see text] production with one or two additional <i>b</i>-jets are reported, using an integrated luminosity of 20.3 fb[Formula: see text] of proton-proton collisions at a centre-of-mass energy of 8 TeV at the Large Hadron Collider, collected with the ATLAS detector. The cross-section times branching ratio for [Formula: see text] events with at least one additional <i>b</i>-jet is measured to be 950 [Formula: see text] 70 (stat.) [Formula: see text] (syst.) fb in the lepton-plus-jets channel and 50 [Formula: see text] 10 (stat.) [Formula: see text] (syst.) fb in the [Formula: see text] channel. The cross-section times branching ratio for events with at least two additional <i>b</i>-jets is measured to be 19.3 [Formula: see text] 3.5 (stat.) [Formula: see text] 5.7 (syst.) fb in the dilepton channel ([Formula: see text], [Formula: see text], and <i>ee</i>) using a method based on tight selection criteria, and 13.5 [Formula: see text] 3.3 (stat.) [Formula: see text] 3.6 (syst.) fb using a looser selection that allows the background normalisation to be extracted from data. The latter method also measures a value of 1.30 [Formula: see text] 0.33 (stat.) [Formula: see text] 0.28 (syst.)% for the ratio of [Formula: see text] production with two additional <i>b</i>-jets to [Formula: see text] production with any two additional jets. All measurements are in good agreement with recent theory predictions.
Vitrification of Excess Plutonium (1994)

As a result of nuclear disarmament activities, many thousands of nuclear weapons are being retired in the US and Russia, producing a surplus of about 50 MT of weapons grade plutonium (Pu) in each country. In addition, the Department of Energy (DOE) has more than 20 MT of Pu scrap, residue, etc., and Russia is also believed to have at least as much of this type of material. The entire surplus Pu inventories in the US and Russia present a clear and immediate danger to national and international security. It is important that a solution be found to secure and manage this material effectively and that such an effort be implemented as quickly as possible. One option under consideration is vitrification of Pu into a relatively safe, durable, accountable, proliferation-resistant form. As a result of decades of experience within the DOE community involving vitrification of a variety of hazardous and radioactive wastes, this existing technology can now be expanded to include immobilization of large amounts of Pu. This technology can then be implemented rapidly using the many existing resources currently available. A strategy to vitrify many different types of Pu will be discussed. In this strategy, the arsenal of vitrification tools, procedures and techniques already developed throughout the waste management community can be used in a staged Pu vitrification effort. This approach uses the flexible vitrification technology already available and can even be made portable so that it may be brought to the source and ultimately, used to produce a common, borosilicate glass form for the vitrified Pu. The final composition of this product can be made similar to nationally and internationally accepted HLW glasses.
Infrared multiphoton dissociation of SF6 in a molecular beam: Observation of F atoms by chemi-ionization detection (1977)

First Page
VOLTTRON Modular Framework: Enabling flexible and scalable deployment solutions (2022)

VOLTTRON<sup>™</sup> is an open-source platform for distributed sensing and control. The platform provides services for collecting and storing data from buildings and devices and provides an environment for developing applications which interact with that data. The platform allows developers to build out their use cases by utilizing these frameworks and integrating new capabilities. To simplify the deployment of systems built on VOLTTRON, a new way of organizing the codebase is being explored. This document details these efforts through a new code repository layout for the VOLTTRON platform and services, and how this new layout provides targeted deployments using standard python deployment packages (wheels). In addition, this paper will discuss the development of third-party agents and how they can be integrated within the VOLTTRON ecosystem. Finally, we will discuss core platform development and direction for the modularized version of VOLTTRON.
Synthesis of Functionally Diverse and Conformationally Constrained Polycyclic Analogues of Proline and Prolinol. (2004)

Alkylation of the monoenolate of &lt;i&gt;N&lt;/i&gt;-Boc-l-pyroglutamic acid methyl ester with a variety of benzylic\nhalides and their homologues gave the corresponding &lt;i&gt;anti-&lt;/i&gt;C-4-alkylated products as major products.\nFormation of the &lt;i&gt;N-&lt;/i&gt;Boc-iminium ion and Friedel−Crafts intramolecular cationic ring closure\nafforded a series of fused 1-azacyclodihydroindene derivatives with interesting topologies. Functional\ndiversity was introduced via further manipulation of pendant groups on the original proline motif\nas well as on the aromatic moiety.