gebhart/patrepeval huggingface dataset:
Effect of Single Oral Dose of Aspirin on Human Platelet Functions and Plasma Plasminogen Activator Inhibitor-1 (1993)

Previous reports documented the inhibitory efficacy of different doses of aspirin on arachidonic acid (AA)-induced platelet aggregation, however, the sensitivity of platelets toward other agonists as well as the effects of aspirin on platelet and plasma plasminogen activator inhibitor-1 (PAI-1) release and levels were not investigated. Hence, the present study was undertaken to investigate the effect and duration of action of a single oral dose (650 mg) of aspirin on human platelet functions (n = 34, normal healthy male and female volunteers) including aggregation, fibrinogen binding and PAI-1 release, and on the plasma level of PAI-1. Aspirin demonstrated a rapid onset of action (at 2 h after ingestion) in specifically inhibiting ex vivo AA-mediated functions including (a) fibrinogen binding to gel-purified platelets, (b) platelet aggregation, and (c) platelet PAI-1 release. A peak reduction of plasma PAI-1 level at 2 h was demonstrated as well. The effect of aspirin on the ex vivo AA-mediated effects (a-c) was shown to last for up to 4 days. However, aspirin treatment resulted in a rebound effect in platelet function (a-c) to other platelet agonists such as adenosine diphosphate or the combination of agonists including adenosine diphosphate, epinephrine, and AA. In conclusion, a single oral dose of aspirin has long-acting effects on AA-induced platelet activation and reduces plasma levels of PAI-1 as well.(ABSTRACT TRUNCATED AT 250 WORDS)
Association of Brain Microstructure and Functional Connectivity With Cognitive Outcomes and Postnatal Growth Among Early School–Aged Children Born With Extremely Low Birth Weight (2023)

This cohort study suggests that the forceps major of the corpus callosum and the superior parietal lobule were vulnerable regions in preterm infants. Preterm birth and suboptimal postnatal growth could have negative associations with brain maturation, including altered microstructure and functional connectivity. Postnatal growth may be associated with differences in long-term neurodevelopment among children born preterm.
Mapping past human land use using archaeological data: A new classification for global land use synthesis and data harmonization (2021)

In the 12,000 years preceding the Industrial Revolution, human activities led to significant changes in land cover, plant and animal distributions, surface hydrology, and biochemical cycles. Earth system models suggest that this anthropogenic land cover change influenced regional and global climate. However, the representation of past land use in earth system models is currently oversimplified. As a result, there are large uncertainties in the current understanding of the past and current state of the earth system. In order to improve representation of the variety and scale of impacts that past land use had on the earth system, a global effort is underway to aggregate and synthesize archaeological and historical evidence of land use systems. Here we present a simple, hierarchical classification of land use systems designed to be used with archaeological and historical data at a global scale and a schema of codes that identify land use practices common to a range of systems, both implemented in a geospatial database. The classification scheme and database resulted from an extensive process of consultation with researchers worldwide. Our scheme is designed to deliver consistent, empirically robust data for the improvement of land use models, while simultaneously allowing for a comparative, detailed mapping of land use relevant to the needs of historical scholars. To illustrate the benefits of the classification scheme and methods for mapping historical land use, we apply it to Mesopotamia and Arabia at 6 kya (c. 4000 BCE). The scheme will be used to describe land use by the Past Global Changes (PAGES) LandCover6k working group, an international project comprised of archaeologists, historians, geographers, paleoecologists, and modelers. Beyond this, the scheme has a wide utility for creating a common language between research and policy communities, linking archaeologists with climate modelers, biodiversity conservation workers and initiatives.
Correction: Corrigendum: Macroscopic ordering of helical pores for arraying guest molecules noncentrosymmetrically (2015)

Nature Communications 6: Article number:8418 (2015); Published: 29 September 2015; Updated: 26 October 2015 The Cambridge Crystallographic Data Centre (CCDC) accession code provided in this article is incorrect; the correct deposition number is 1059112.
Distinct binding of PET ligands PBB3 and AV-1451 to tau fibril strains in neurodegenerative tauopathies (2016)

Diverse neurodegenerative disorders are characterized by deposition of tau fibrils composed of conformers (i.e. strains) unique to each illness. The development of tau imaging agents has enabled visualization of tau lesions in tauopathy patients, but the modes of their binding to different tau strains remain elusive. Here we compared binding of tau positron emission tomography ligands, PBB3 and AV-1451, by fluorescence, autoradiography and homogenate binding assays with homologous and heterologous blockades using tauopathy brain samples. Fluorescence microscopy demonstrated intense labelling of non-ghost and ghost tangles with PBB3 and AV-1451, while dystrophic neurites were more clearly detected by PBB3 in brains of Alzheimer's disease and diffuse neurofibrillary tangles with calcification, characterized by accumulation of all six tau isoforms. Correspondingly, partially distinct distributions of autoradiographic labelling of Alzheimer's disease slices with 11C-PBB3 and 18F-AV-1451 were noted. Neuronal and glial tau lesions comprised of 4-repeat isoforms in brains of progressive supranuclear palsy, corticobasal degeneration and familial tauopathy due to N279K tau mutation and 3-repeat isoforms in brains of Pick's disease and familial tauopathy due to G272V tau mutation were sensitively detected by PBB3 fluorescence in contrast to very weak AV-1451 signals. This was in line with moderate 11C-PBB3 versus faint 18F-AV-1451 autoradiographic labelling of these tissues. Radioligand binding to brain homogenates revealed multiple binding components with differential affinities for 11C-PBB3 and 18F-AV-1451, and higher availability of binding sites on progressive supranuclear palsy tau deposits for 11C-PBB3 than 18F-AV-1451. Our data indicate distinct selectivity of PBB3 compared to AV-1451 for diverse tau fibril strains. This highlights the more robust ability of PBB3 to capture wide-range tau pathologies.
Early Text Classification Using Multi-Resolution Concept Representations (2018)

Adrian Pastor López-Monroy, Fabio A. González, Manuel Montes, Hugo Jair Escalante, Thamar Solorio. Proceedings of the 2018 Conference of the North American Chapter of the Association for Computational Linguistics: Human Language Technologies, Volume 1 (Long Papers). 2018.
Advanced test cell diagnostics for gas turbine engines (2002)

Improved test cell diagnostics capable of detecting and classifying engine mechanical and performance faults as well as instrumentation problems is critical to reducing engine operating and maintenance costs while optimizing test cell effectiveness. Proven anomaly detection and fault classification techniques utilizing engine Gas Path Analysis (GPA) and statistical/empirical models of structural and performance related engine areas can now be implemented for real-time and post-test diagnostic assessments. Integration and implementation of these proven technologies into existing USAF engine test cells presents a great opportunity to significantly improve existing engine test cell capabilities to better meet today's challenges. A suite of advanced diagnostic and troubleshooting tools have been developed and implemented for gas turbine engine test cells as part of the Automated Jet Engine Test Strategy (AJETS) program. AJETS is an innovative USAF program for improving existing engine test cells by providing more efficient and advanced monitoring, diagnostic and troubleshooting capabilities. This paper describes the basic design features of the AJETS system; including the associated data network, sensor validation and anomaly detection/diagnostic software that was implemented in both a real-time and post-test analysis mode. These advanced design features of AJETS are currently being evaluated and advanced utilizing data from TF39 test cell installations at Travis AFB and Dover AFB.
A Modeling Framework to Estimate Patellofemoral Joint Cartilage Stress In Vivo (2005)

The methods presented in this article offer a novel approach to calculate PF joint cartilage stress in vivo. Future efforts will use this modeling pipeline to further our knowledge of PF pain and potential rehabilitation strategies.
The effect of interface properties on nickel base alloy composites (1995)

This program was performed to assess the extent to which mechanical behavior models can predict the properties of sapphire fiber/nickel aluminide matrix composites and help guide their development by defining improved combinations of matrix and interface coating. The program consisted of four tasks: 1) selection of the matrices and interface coating constituents using a modeling-based approach; 2) fabrication of the selected materials; 3) testing and evaluation of the materials; and 4) evaluation of the behavior models to develop recommendations. Ni-50Al and Ni-20AI-30Fe (a/o) matrices were selected which gave brittle and ductile behavior, respectively, and an interface coating of PVD YSZ was selected which provided strong bonding to the sapphire fiber. Significant fiber damage and strength loss was observed in the composites which made straightforward comparison of properties with models difficult. Nevertheless, the models selected generally provided property predictions which agreed well with results when fiber degradation was incorporated. The presence of a strong interface bond was felt to be detrimental in the NiAI MMC system where low toughness and low strength were observed.
360-Degree Video Streaming with MPEG-DASH (2018)

Virtual reality (VR) has gained a lot of attention due to market availability of consumer devices. A challenge for wider use is the ability to stream VR content to the user. This paper looks at aspects of 360° video streaming and the considerations for possible solutions. The primary focus lies on current efforts to develop standards for interoperable 360° video streaming. These standards include the Moving Picture Experts Group's (MPEG) work on omnidirectional media format (OMAF) and the integration in MPEG dynamic adaptive streaming over HTTP, which is considered a cornerstone of 360° video streaming services with OMAF content. This paper also discusses content protection approaches and considerations.
Relationship Between Physiological Variables and Linear Bat Swing Velocity of High School Baseball Players (2008)

PURPOSE: To determine the relationship of physiological variables to linear bat swing velocity before and after completing a 12-week resistance training program. METHODS: Forty-nine high school baseball players (age = 15.4 ± 1.2 yr) were randomly assigned to 1 of 2 training groups. Group 1 (n = 24) and group 2 (n = 25) both performed a stepwise periodized resistance exercise program and took 100 swings a day, 3 days a week for 12 weeks with their normal game bat. Group 2 performed additional rotational and full-body medicine ball exercises 3 days a week for 12 weeks. Ten physiological and sport-specific skill variables were measured pre-and posttraining. Parallel squat (PS) and bench press (BP) were measured by a 3 repetition maximum (RM) strength test. Estimation of 1RM for both tests was then calculated. Dominant (DTRS) and non-dominant torso rotational strength (NDTRS) were measured by a torso rotation machine. Sequential hip-torso-arm rotational strength was measured by a medicine ball hitter's throw. A 3-site skinfold test was used to determine percent body fat (%BF) and lean body mass (LBM). Angular hip velocity (AHV), angular shoulder velocity (ASV), and linear bat swing velocity (BV) were measured by a motion capture system which identified and digitally processed reflective markers attached to participant's bat and body. RESULTS: Correlation coefficients were calculated for all variables by utilizing a correlation matrix from raw scores for both the pre and posttraining data. Statistical analysis indicated a significantly high positive relationship (p < 0.05) between BV and post-NDTRS (r = 0.83). Significant moderately high positive relationships were indicated between BV and pre-NDTRS (r = 0.62) and post-DTRS (r = 0.74). Significantly moderate positive relationships were indicated between BV and pre- LBM, PS, BP, and ASV (r = 0.58, 0.48, 0.49, and 0.53); BV and post-LBM, medicine ball hitter's throw, PS, and BP (r= 0.59, 0.57, 0.55, & 0.48). CONCLUSION: These data suggest that significant relationships do exist between physiological variables and BV, but one cannot interpret this to mean a causal relationship. It also suggests that strength training programs designed to improve BV should emphasize improving rotational strength, LBM, lower and upper body strength, and explosive rotational power.
Response to Comments on "A Centrosome-Independent Role for γ-TuRC Proteins in the Spindle Assembly Checkpoint" (2007)

Weaver and Cleveland and Taylor et al . contend that our data on the involvement of the γ-tubulin ring complex (γ-TuRC) in the spindle assembly checkpoint (SAC) can be fully explained by kinetochore-derived checkpoint signaling. We maintain that (i) the interactions of γ-TuRC with Cdc20 and BubR1, and (ii) the activation of SAC by γ-TuRC depletion, in addition to the abrogation of kinetochore-microtubule interactions, argue for a more complex mechanism of SAC signaling.
Electrical pulse fabrication of graphene nanopores in electrolyte solution (2015)

Nanopores in graphene membranes can potentially offer unprecedented spatial resolution for single molecule sensing, but their fabrication has thus far been difficult, poorly scalable, and prone to contamination. We demonstrate an <i>in-situ</i> fabrication method that nucleates and controllably enlarges nanopores in electrolyte solution by applying ultra-short, high-voltage pulses across the graphene membrane. This method can be used to rapidly produce graphene nanopores with subnanometer size accuracy in an apparatus free of nanoscale beams or tips.
The role of the extra-framework cations in the adsorption of CO2 on faujasite Y (2010)

A purely electrostatic picture predicts that small, more polarizing cations adsorb more strongly than the large ones. In the case of the adsorption of CO(2) on faujasite Y, however, the inverse order is found at low pressure: CsY and KY adsorb stronger than NaY and LiY. This trend cannot be explained by a simple monopole-dipole or monopole-quadrupole interaction of CO(2) with a single cation. Therefore, we have conducted a combined adsorption, IR and DFT study in order to shed light on this phenomenon. Our results show that a simultaneous interaction of CO(2) with the cations (located in the hexagonal window between supercage and sodalite cage) and framework oxygen atoms (in the 12-ring connecting two supercages) can explain the strong adsorption of CO(2) on CsY and KY. We also discuss the effect of van der Waals interactions. Although there is a redistribution of the charge of three framework oxygen atoms in the 12-ring towards the carbon atom of CO(2), the geometry of CO(2) remains almost linear. The adsorption mode can, therefore, be interpreted as a carbonate precursor. In zeolite Y, this acid-base like interaction is more important than polarization of CO(2) by the cation only. Furthermore, evidence for an adsorption mode where CO(2) binds simultaneously to two cations in the supercage was detected by DFT, as already reported for Na-ferrierite. This adsorption mode is, however, strongly dependant on the distance between two cations in the supercage and is only favorable in the case of KY.
Long range audio and audio-visual event detection using a laser Doppler vibrometer (2010)

Association of audio events with video events presents a challenge to a typical camera-microphone approach in order to capture AV signals from a large distance. Setting up a long range microphone array and performing geo-calibration of both audio and video sensors is difficult. In this work, in addition to a geo-calibrated electro-optical camera, we propose to use a novel optical sensor - a Laser Doppler Vibrometer (LDV) for real-time audio sensing, which allows us to capture acoustic signals from a large distance, and to use the same geo-calibration for both the camera and the audio (via LDV). We have promising preliminary results on association of the audio recording of speech with the video of the human speaker.
Immunotherapy and targeted therapy for cervical cancer: an update (2015)

The prognosis of patients with metastatic cervical cancer is poor with a median survival of 8-13 months. Despite the potency of chemotherapeutic drugs, this treatment is rarely curative and should be considered palliative only. In the last few years, a better understanding of Human papillomavirus tumor-host immune system interactions and the development of new therapeutics targeting immune check points have renewed interest in the use of immunotherapy in cervical cancer patients. Moreover, next generation sequencing has emerged as an attractive option for the identification of actionable driver mutations and other markers. In this review, we provide background information on the molecular biology of cervical cancer and summarize immunotherapy studies, targeted therapies, including those with angiogenesis inhibitors and tyrosine kinase inhibitors recently completed or currently on-going in cervical cancer patients.
Dietary and hormonal regulation of aldolase B gene expression. (1985)

Aldolase B is an enzyme of the glycolytic pathway whose activity and mRNA levels in the liver fluctuate according to dietary status. Both the enzyme activity and the mRNA concentration decline during fasting and increase four- to eightfold upon refeeding of a carbohydrate-rich diet. The mechanism, however, of the mRNA induction remains unknown. To elucidate the mechanisms that regulate this induction responsive to dietary stimuli, we have studied the roles of hormones and glycolytic substrates on aldolase B gene expression in three tissues that synthesize the enzyme. Using a cDNA probe complementary to rat aldolase B mRNA, we determined the amount of cytoplasmic RNAs in the liver, kidney, and small intestine of normal, adrenalectomized, thyroidectomized, diabetic, and glucagon- or cAMP-treated animals refed either a fructose-rich or a maltose-rich diet. The in vivo hormonal control of gene expression was found to be very different in the three organs tested. In the liver, cortisone and thyroid hormones were required for the induction of the specific mRNA by carbohydrates, while in the kidney none of the hormonal modifications tested altered the level of mRNA induction. In the liver, but not in the kidney, diabetes and glucagon administration abolished the induction of aldolase B mRNAs in animals refed the maltose-rich diets. In the small intestine, only diabetes and thyroidectomy affected the gene expression. Finally, no induction occurred when normal fasted rats were given any of the hormones. Thus, the in vivo hormonal control of liver aldolase B gene expression differs significantly from that of kidney and small intestine. In the liver, the mRNA induction requires the presence of dietary carbohydrates, of permissive hormones, and the cessation of glucagon release, while in the kidney, the induction of the mRNAs by fructose occurs regardless of the hormonal status of the animals. The hormonal control of aldolase B mRNA levels in the small intestine is intermediate.
TARGETING MICROSPHERE DELIVERY TO LABELED VASCULAR TISSUE USING BIOTTN & NEUTRAVIDIN (2000)

A technique to label segments of the vasculature to attract targeted microspheres was developed. Such a system might ultimately be utilized for ongoing drug delivery or gene therapy to modified vascular regions following a surgical or catheter-based procedure. Vascular cells were labeled using the amine reactive polymer, N-hydroxysuccinimide-poly (ethylene glycol)-biotin (NHS-PEG-biotin), MW 3,400. The kinetics and extent of cell surface modification were quantified with flow cytometry on cultured human coronary artery endothelial cells using neutravidin-FITC. Fluorescent polystyrene microspheres surface-modified with neutravidin (1 um diameter) were used to examine targeted binding to rabbit femoral and bovine carotid arteries labeled with NHS-PEG-biotin under controlled wall shear conditions ex vivo. Flow cytometric data demonstrated 2.6x106 PEG-biotin molecules/cell after incubation with a 10 mM solution of NHS-PEG-biotin for 1 min. Bovine carotid arteries treated with 4–10 mM NHS-PEG-biotin bound 45+/−4 microspheres/mm2 of tissue compared to 4+/−0.5 for untreated vascular segments (p < 0.05). Similarly, rabbit femoral arteries bound 29+/−7 microspheres/mm2 vs. 3+/−0.3 for the control. These data demonstrate the feasibility of modifying vascular tissue with ligands for subsequent binding by targeted microspheres.
Ferrielectric and antiferroelectric chiral twin liquid crystals showing a stable chiral nematic phase (2002)

Abstract A homologous series of chiral twin liquid crystals possessing identical chiral moieties at both peripheral ends, i.e. optically active α,ω -bis{4-[(4′-(1-methylheptyloxycarbonyl)-4-biphenylyl)oxycarbony]phenoxy}alkanes, has been prepared and their liquid crystalline properties investigated. The homologues preferred to show the ferrielectric and/or antiferroelectric phase rather than the ferroelectric phase. With ascending central spacer length, the temperature range of the ferrielectric phase became narrow and eventually disappeared for the dodecyl homologue, suggesting that the coupling in motion and/or direction between two mesogenic parts of each twin molecule has an important effect on the stabilization of the ferrielectric phase. The octyl and dodecyl homologues showed a wide temperature range chiral nematic phase (ca. 10°C or more), so that these compounds were found to be the first examples showing antiferroelectric and/or ferrielectric phases with a broad temperature range of the chiral nematic phase. X-ray diffraction studies showed that the homologues tend to form a mono-layered structure. The formation of a relatively well defined layered structure was also indicated, which is considered to be important for generating anticlinic ordering in the antiferroelectric and ferrielectric phases. An isotropic-isotropic transition characterized by the emergence of a broad diffuse DSC peak was observed for the even-membered homologues.
Long-term tolerance of islet allografts in nonhuman primates induced by apoptotic donor leukocytes (2019)

Immune tolerance to allografts has been pursued for decades as an important goal in transplantation. Administration of apoptotic donor splenocytes effectively induces antigen-specific tolerance to allografts in murine studies. Here we show that two peritransplant infusions of apoptotic donor leukocytes under short-term immunotherapy with antagonistic anti-CD40 antibody 2C10R4, rapamycin, soluble tumor necrosis factor receptor and anti-interleukin 6 receptor antibody induce long-term (≥1 year) tolerance to islet allografts in 5 of 5 nonsensitized, MHC class I-disparate, and one MHC class II DRB allele-matched rhesus macaques. Tolerance in our preclinical model is associated with a regulatory network, involving antigen-specific Tr1 cells exhibiting a distinct transcriptome and indirect specificity for matched MHC class II and mismatched class I peptides. Apoptotic donor leukocyte infusions warrant continued investigation as a cellular, nonchimeric and translatable method for inducing antigen-specific tolerance in transplantation.