gebhart/patrepeval huggingface dataset:
Efficient Decomposition of Quantum Gates (2004)

Optimal implementation of quantum gates is crucial for designing a quantum computer. We consider the matrix representation of an arbitrary multiqubit gate. By ordering the basis vectors using the Gray code, we construct the quantum circuit which is optimal in the sense of fully controlled single-qubit gates and yet is equivalent with the multiqubit gate. In the second step of the optimization, superfluous control bits are eliminated, which eventually results in a smaller total number of the elementary gates. In our scheme the number of controlled NOT gates is O(4(n)) which coincides with the theoretical lower bound.
Molecular signaling in bone fracture healing and distraction osteogenesis. (1999)

The process of fracture healing has been described in detail in many histological studies. Recent work has focused on the mechanisms by which growth and differentiation factors regulate the fracture healing process. Rapid progress in skeletal cellular and molecular biology has led to the identification of many signaling molecules associated with the formation of skeletal tissues, including members of the transforming growth factor-beta (TGF-beta) superfamily and the insulin-like growth factor (IGF) family. Increasing evidence indicates that they are critical regulators of cellular proliferation, differentiation, extracellular matrix biosynthesis and mineralization. Limb lengthening procedure (distraction osteogenesis) is a relevant model to investigate the in vivo correlation between mechanical stimulation and biological responses as the callus is stretched by a proper rate and rhythm of mechanical strain. This model also provides additional insights into the molecular and cellular events during bone fracture repair. TGF-beta 1 was significantly increased in both the distracted callus and the fracture callus. The increased level of TGF-beta 1, together with a low concentration of calcium and an enhanced level of collagen synthesis, was maintained in the distracted callus as long as mechanical strain was applied. Less mineralization is also associated with a low level of osteocalcin production. These observations provide further insights into the molecular basis for the cellular events during distraction osteogenesis.
ChemInform Abstract: STRUCTURAL AND STEREODYNAMIC STUDIES ON MOLECULAR EARLY TRANSITION METAL DERIVATIVES. 4. SYNTHESIS, CRYSTAL STRUCTURE, AND MOLECULAR CONSTITUTION OF SOLUTIONS OF BIS(ALKOXO)TRICHLORONIOBIUM(V)‐HEXAMETHYLPHOSPHORTRIAMIDE ADDUCTS (1978)

Abstract Die 1:1‐ Verbindungen von Trichloro‐bis‐[methoxo]‐ bzw. ‐[isopropoxo]‐niob mit dem Phosphorsäuretriamid wurden durch Disproportionierung der Dimeren [NbC1,(OR)3], in CH,CI, oder Ether in Gegenwart der Phosphorverbindung mit 35 bzw. 30% Ausb. erhalten.
Advances in polarization-maintaining, single-mode, hollow-core fibers (2016)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text J. W. Nicholson, B. J. Mangan, R. S. Windeler, T. Kremp, G. Puc, M. Corrado, Y. Dulashko, and D. J. DiGiovanni, "Advances in polarization-maintaining, single-mode, hollow-core fibers," in Conference on Lasers and Electro-Optics, OSA Technical Digest (2016) (Optica Publishing Group, 2016), paper SW4I.2. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Evaluation d’une méthode d’imagerie X en microfluidique : cas du remplissage de microcanaux en forme de « T » (2006)

International audience
Sensing of nucleic acid sequences using unmodifiednucleic acid as a probe (2007)

We present a strategy to generate a light-up fluorophore-aptamer pair. The strategy was based on a modification of a conventional DNA-staining dye to suppress its affinity to the original targets, and subsequent re-selection of aptamers that would bind to the modified dye. Along this line, we prepared an environmental polarity-sensitive Hoechst derivative with low affinity to the usual AT-rich dsDNA targets. DNA aptamers, in vitro selected from a random pool, worked as a trigger to enhance the fluorescence of an otherwise nonfluorescent Hoechst derivative.
31P spin–lattice and singlet order relaxation mechanisms in pyrophosphate studied by isotopic substitution, field shuttling NMR, and molecular dynamics simulation (2022)

Nuclear spin relaxation mechanisms are often difficult to isolate and identify, especially in molecules with internal flexibility. Here we combine experimental work with computation in order to determine the major mechanisms responsible for <sup>31</sup>P spin-lattice and singlet order (SO) relaxation in pyrophosphate, a physiologically relevant molecule. Using field-shuttling relaxation measurements (from 2 μT to 9.4 T) and rates calculated from molecular dynamics (MD) trajectories, we identified chemical shift anisotropy (CSA) and spin-rotation as the major mechanisms, with minor contributions from intra- and intermolecular coupling. The significant spin-rotation interaction is a consequence of the relatively rapid rotation of the -PO<sub>3</sub><sup>2-</sup> entities around the bridging P-O bonds, and is treated by a combination of MD simulations and quantum chemistry calculations. Spin-lattice relaxation was predicted well without adjustable parameters, and for SO relaxation one parameter was extracted from the comparison between experiment and computation (a correlation coefficient between the rotational motion of the groups).
Energy-aware and quality-scalable data placement and retrieval for disks in video server environments (2011)

As the popularity of video streaming over the Internet grows, energy consumption in video server environments which store and retrieve video data increases as well. Previous work has shown that video quality delivered to clients can be scaled in order to serve more concurrent video requests and/or reduce energy consumption of server disks. We propose a data placement strategy for such quality scaling methods which distributes video data within a disk based on its priority/importance. Results show that in doing so the disk can retrieve data with greater efficiency and serve lower quality video to more clients than previously investigated strategies.
Simplifying Nickel(0) Catalysis: An Air-stable, COD-free Nickel Precatalyst for the Internally-selective Benzylation of Terminal Alkenes (2013)

The synthesis and characterization of the air-stable nickel(II) complex trans-(PCy2Ph)2Ni(o-tolyl)Cl is described in conjunction with an investigation of its use for Mizoroki Heck-type, room temperature, internally-selective coupling of substituted benzyl chlorides with terminal alkenes. This reaction, which employs a terminal alkene as an alkenylmetal equivalent, provides rapid, convergent access to substituted allylbenzene derivatives in high yield and with regioselectivity greater than 95:5 in nearly all cases. The reaction is operationally simple, can be carried out on the bench-top with no purification or degassing of solvents or reagents, and requires no exclusion of air or water during setup. Synthesis of the precatalyst is accomplished through a straightforward procedure that employs inexpensive, commercially available reagents, requires no purification steps, and proceeds in high yield.
Adaptive intracavity correction of the pulsed YAG laser radiation (1992)

This paper presents the experimental results on the intracavity adaptive correction of the thermooptical phase distortions in the pulsed YAG-laser. Average 3-times increase in the beam axes intensity has been achieved with only 10 loss in the total output laser pulse energy. The system stability to variations of the thermooptical distortions has been demonstrated. 1 .
Polyhomologation and ATRP: A Perfect Partnership toward Unique Polyethylene-Based Architectures (2018)

The recent developments in organoborane initiated C1 polymerization (chain grows by one atom at a time) of ylides opens unique horizons towards well-defined/perfectly linear polymethylenes (equivalent to polyethylenes, PE). On the other hand, atom transfer radical polymerization (ATRP) is an excellent and powerful controlled/living polymerization for polar monomers such as (meth)acrylates and styrenes. In this Chapter the partnership of these two living polymerizations towards the synthesis of well-defined PE (perfectly linear)-based block copolymers, with unprecedented macromolecular architectures, is presented. Some ideas about new ylide monomers are also discussed.
Readback bit shift with finite pole-length heads on perpendicular media (1983)

Perpendicular writing fields are calculated for finite pole-length gapped heads, with and without a permeable layer beneath the magnetic medium. These head fields are used to compute readback waveforms from ideal perpendicular transitions, which are detected both by zero-crossings and by inflection points of the waveform. Linear readback bit shift, given by the difference between detected and written transitions, is normalized to half the minimum transition spacing. For detection by waveform zero-crossing, bit shifts are unacceptably large with an under layer. Without an underlayer, detection by inflection point is considerably better than by waveform zero-crossing. Surprisingly, bit shifts from inflection points are only marginally better without an underlayer than with one. A recording system with an underlayer may in fact give superior performance because of other contributions to the total bit shift.
Comparison of the Sequential High-Dose Chemotherapy Followed by Autologous Stem Cell Support with and without Rituximab in Relapsed and Refractory Aggressive Non-Hodgkin’s Lymphoma. (2004)

Abstract Introduction: Combination chemotherapy can cure patients (pts) with Non-Hodgkin’s lymphoma (NHL), but those with relapse still have a poor prognosis. High-dose chemotherapy (HDCT) with autologous stem cell support (ASCT) can improve the outcome of these pts. Rituximab demonstrated encouraging activity in aggressive NHL and showed low toxicity in the setting of combined immunochemotherapy. To investigate the influence of addition of rituximab to the intensified salvage program followed by a final myeloablative course with stem cell reinfusion we compared the group of patients treated with this program - immuntherapy group (IT) with the standard therapy group (ST) of patients treated with the same program without rituximab. Patients and methods: Eligibility criteria for both groups were as follows: age 18–67 years, eligibility for HDCT, histologically proven CD20+ relapsed or progressive NHL. Treatment program starts with two cycles DHAP (dexamethasone, cytarabine, cisplatin); pts with PR or CR receive cyclophosphamide (4g/m2) followed by PBSC harvest; methotrexate 8g/m2 and vincristine 1,4mg/m2; and etoposide 2g/m2. The final myeloablative course is BEAM followed by ASCT. Pts in IT received additionally rituximab (375mg/m²) to the each chemotherapy cycle. Results: In the immuntherapy and standard therapy group were enrolled 23 and 57 pts, respectively. There were 18 (78%) IT and 34 (60%) ST pts with relapsed and 5 (22%) IT and 23 (40%) ST pts with refractory disease. The majority of pts in both groups received CHOP-like regimens as first line treatment (91% IT vs. 79% ST). The response rate at the final evaluation for all patients was in IT 61% (52% CR and 9% PR) and in ST 43% (32% CR and 11% PR). The overall response rate (OR) for patients who responded to 2 cycles DHAP was in IT 83% (71% CR and 12% PR) and in ST 59% (44% CR and 15% PR). The therapy toxicity was tolerable and comparable in both groups. Conclusion: The preliminary results suggest better therapy outcome in patient with sequential high-dose chemotherapy with rituximab compared to pts treated with the same therapy regimen without additional antibody. The combination regimen allows effective mobilization of stem cells. The tolerability of the final myeloablative BEAM was in both groups not affected by rapid sequential administration of DHAP and high doses of cyclophosphamide, methotrexate, etoposide and rituximab. The toxicity was tolerable in both groups. The full results of match pair and multivariate analysis as well as OS and FF2F will be presented.
Photonic Integrated Circuits for Optical Routing and Switching Applications (2011)

We report on the latest advances in implementation of integrated photonic components required for optical routing and switching: tunable wavelength converters, mode-locked lasers, active optical switches and optical buffers.
Transport of tissue inhibitor of metalloproteinases‐1 through cartilage: Contributions of fluid flow and electrical migration (1998)

The preservation of the structure of articular cartilage depends on the availability of inhibitors of matrix-degrading enzymes. Tissue inhibitor of metalloproteinases-1 is thought to be an important contributor to the integrity of the matrix of articular cartilage, but the mechanisms that regulate its availability within the tissue are poorly understood. These studies elucidate the contributions of diffusion, fluid flow, and electrical migration to the transport of iodinated recombinant human tissue inhibitor of metalloproteinases-1 through explants of adult bovine articular cartilage under conditions relevant to the loading of cartilage. With use of measured partition coefficients of the cartilage explants, the diffusivity of the inhibitor was 0.5-1.6 x 10(-7) cm2/sec. Fluid velocities that were induced by applying an electrical current across the cartilage disks increased the flux of the inhibitor by approximately 20 to more than 150-fold compared with the effect of diffusion alone for the range of current densities that were applied. We examined the contribution of electrophoretic migration by titrating the charge on the inhibitor during measurements of flux and found that flux in the presence of the applied current decreased as the inhibitor became more negatively charged. Enhancements in the flux of the inhibitor were observed relative to the flux during diffusion alone even under conditions in which electrophoretic migration opposed the flux due to fluid flow, suggesting that of the transport mechanisms tested, fluid flow was dominant. These results suggest that the physical phenomena present during physiologic loading conditions (e.g., fluid flows and streaming currents) can affect the transport of tissue inhibitor of metalloproteinases-1 through the matrix of cartilage.
On-going evaluation of traffic control devices. (2010)

"This project was established to provide a means of conducting small-scale research activities on an as needed basis so that the results could be available within months of starting the specific research. This report summarizes the small-scale research activities that were conducted between September 2008 and August 2009." (p. i).
A novel method for initial rotor position estimation for IPM synchronous machine drives (2004)

Novel methods for initial position estimation during start-up are presented for interior permanent magnet synchronous machine drives. The magnet cavities in the IPMSM rotor create a sizable difference in the inductances of the two orthogonal rotor axes. This spatial saliency based on the rotor position makes it possible to use persistent, rotating or pulsating vector, carrier frequency image tracking techniques to reliably identify and track the orientation of the d and q axes even when the rotor is at standstill. However, additional details in the saliency image must be used to identify the polarization of the magnets in order to distinguish the north and south poles. The magnet polarity is identified by using magnetic saturation effects on the saliency image to uniquely identify the magnet pole polarity being tracked. Carrier currents for both rotating and pulsating voltage carrier injection are derived by using IPM machine model including saturation and verified by measured carrier current components. Experimental results show that the proposed algorithms are capable of reliable and fast initial position estimation including the polarity at standstill.
An inter‐species protein–protein interaction network across vast evolutionary distance (2016)

In cellular systems, biophysical interactions between macromolecules underlie a complex web of functional interactions. How biophysical and functional networks are coordinated, whether all biophysical interactions correspond to functional interactions, and how such biophysical-versus-functional network coordination is shaped by evolutionary forces are all largely unanswered questions. Here, we investigate these questions using an "inter-interactome" approach. We systematically probed the yeast and human proteomes for interactions between proteins from these two species and functionally characterized the resulting inter-interactome network. After a billion years of evolutionary divergence, the yeast and human proteomes are still capable of forming a biophysical network with properties that resemble those of intra-species networks. Although substantially reduced relative to intra-species networks, the levels of functional overlap in the yeast-human inter-interactome network uncover significant remnants of co-functionality widely preserved in the two proteomes beyond human-yeast homologs. Our data support evolutionary selection against biophysical interactions between proteins with little or no co-functionality. Such non-functional interactions, however, represent a reservoir from which nascent functional interactions may arise.
Precise T cell recognition programs designed by transcriptionally linking multiple receptors (2020)

Living cells often identify their correct partner or target cells by integrating information from multiple receptors, achieving levels of recognition that are difficult to obtain with individual molecular interactions. In this study, we engineered a diverse library of multireceptor cell-cell recognition circuits by using synthetic Notch receptors to transcriptionally interconnect multiple molecular recognition events. These synthetic circuits allow engineered T cells to integrate extra- and intracellular antigen recognition, are robust to heterogeneity, and achieve precise recognition by integrating up to three different antigens with positive or negative logic. A three-antigen AND gate composed of three sequentially linked receptors shows selectivity in vivo, clearing three-antigen tumors while ignoring related two-antigen tumors. Daisy-chaining multiple molecular recognition events together in synthetic circuits provides a powerful way to engineer cellular-level recognition.
Où en sont les techniques ? (1993)

Baulieu Étienne-Émile, Kahn Axel, Papiernik Émile, Pasternak Guita, Tchobroutsky , Caillavet Henri, Catonné Jean-Philippe. Où en sont les techniques ?. In: Raison présente, n°105, 1er trimestre 1993. La maitrise du vivant. pp. 9-41.
Unreactive 1-azadiene and reactive 2-azadiene in Diels-Alder reaction of pentachloroazacyclopentadienes (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUnreactive 1-azadiene and reactive 2-azadiene in Diels-Alder reaction of pentachloroazacyclopentadienesPaul H. Daniels, John L. Wong, Jerry L. Atwood, Larry G. Canada, and Robin D. RogersCite this: J. Org. Chem. 1980, 45, 3, 435–440Publication Date (Print):February 1, 1980Publication History Published online1 May 2002Published inissue 1 February 1980https://pubs.acs.org/doi/10.1021/jo01291a011https://doi.org/10.1021/jo01291a011research-articleACS PublicationsRequest reuse permissionsArticle Views331Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
T lymphocyte repertoire in Theiler's virus encephalomyelitis: the nonspecific infiltration of the central nervous system of infected SJL/J mice is associated with a selective local T cell expansion (1995)

Theiler's virus causes, in the susceptible SJL/J mouse, a chronic demyelinating disease that resembles multiple sclerosis. Demyelination is at least in part immune mediated and coincides with the infiltration of the central nervous system by T lymphocytes. We analyzed the repertoire of the T cell receptor (TcR) beta-chain for each V beta-J beta combination, in spinal cord and spleen T cells of infected animals. All V beta families were detected in spinal cord as well as in spleen, as if the central nervous system were undiscriminantly invaded by T cells in the infected animals. Some T cells, defined by specific V beta-J beta combinations, were expanded in the spinal cord but not in the spleen, most probably because of an antigen-driven response. The TcR beta-chain repertoire of infiltrating T cells was the same at the onset of demyelination as when the disease was full-blown. These results provide the first description of the repertoire of the T cells which infiltrate the central nervous system during the course of this disease.
An immuno-wall microdevice exhibits rapid and sensitive detection of IDH1-R132H mutation specific to grade II and III gliomas (2016)

World Health Organization grade II and III gliomas most frequently occur in the central nervous system (CNS) in adults. Gliomas are not circumscribed; tumor edges are irregular and consist of tumor cells, normal brain tissue, and hyperplastic reactive glial cells. Therefore, the tumors are not fully resectable, resulting in recurrence, malignant progression, and eventual death. Approximately 69-80% of grade II and III gliomas harbor mutations in the isocitrate dehydrogenase 1 gene (<i>IDH1</i>), of which 83-90% are found to be the <i>IDH1-R132H</i> mutation. Detection of the <i>IDH1-R132H</i> mutation should help in the differential diagnosis of grade II and III gliomas from other types of CNS tumors and help determine the boundary between the tumor and normal brain tissue. In this study, we established a highly sensitive antibody-based device, referred to as the immuno-wall, to detect the <i>IDH1-R132H</i> mutation in gliomas. The immuno-wall causes an immunoreaction in microchannels fabricated using a photo-polymerizing polymer. This microdevice enables the analysis of the <i>IDH1</i> status with a small sample within 15 min with substantially high sensitivity. Our results suggested that 10% content of the <i>IDH1-R132H</i> mutation in a sample of 0.33 μl volume, with 500 ng protein, or from 500 cells is theoretically sufficient for the analysis. The immuno-wall device will enable the rapid and highly sensitive detection of the <i>IDH1-R132H</i> mutation in routine clinical practice.
Relaxation of nuclear spin polarized {sup 129}Xe due to interactions with surfaces (1993)

We have measured the temperature and magnetic field dependence of wall induced spin relaxation of nuclear polarized {sup 129}Xe in pyrex cells with a variety of inner surface preparations. Depolarization mechanisms which we are currently exploring include the spin rotation interaction, paramagnetic sites, and potentially, spin exchange between the {sup 129}Xe nuclear spins and the nuclear spins of the surface. If spin exchange is occurring, this work could lead to a new technique for producing spin-polarized solids.