gebhart/patrepeval huggingface dataset:
Functionalized Graphene Sheets as Molecular Templates for Controlled Nucleation and Self‐Assembly of Metal Oxide‐Graphene Nanocomposites (2012)

By using a combination of theoretical and experimental techniques, it is demonstrated that functionalized graphene sheets (FGS) can function as a new class of molecular templates to direct the nucleation, crystalline phase transition, and self-assembly process of surfactant micelles and metal oxides. Novel, three-dimensional FGS-metal oxide nanocomposite materials with an ordered mesoporous structure can be synthesized.
Spondylotic C-3 Radiculopathy in a Professional Football Player (1987)

In brief: Spondylotic C-3 radiculopathy resulting from a football injury occurs only rarely. In this case, a professional football player complained of pain and paresthesia over his left ear and the left side of his neck. Computed tomography and magnetic resonance imaging revealed a prominent foraminal osteophyte at the C-2 to C-3 cervical levels. With treatment that included anti-inflammatory medication, the patient's symptoms disappeared within two weeks, and he resumed play with no return of symptoms. In addition to this case, the authors discuss the pathogenesis of spondylotic radiculopathy as well as more common football-related injuries to the cervical nerve roots and brachial plexus.
From molecule to man - using electrospray Fourier Transform ion cyclotron resonance mass spectrometry (ESI-FTICR-MS) in proteomics (2003)

From molecule to man - using electrospray Fourier Transform ion cyclotron resonance mass spectrometry (ESI-FTICR-MS) in proteomics
The clinical application of an ELISA technique for the detection of antihistone antibodies. (1986)

A rapid reproducible technique for measuring antihistone antibodies is described in which unfractioned nuclear histones covalently bonded to plastic discs are employed in an ELISA system. All 20 patients with drug induced lupus erythematosus had antihistone antibodies, usually at high titer. In contrast, 22% of 18 asymptomatic patients with drug induced antinuclear antibodies (ANA), 15% of 20 patients with seropositive RA and 42% of 60 patients with systemic lupus erythematosus (SLE) had detectable antihistone antibodies. High titers of antihistone antibodies were not seen in drug induced ANA or RA. This assay differentiates between patients with drug induced lupus and drug induced ANA (p less than 0.01) and drug induced lupus erythematosus and SLE (p less than 0.01). In patients with SLE antihistone antibodies had no association with disease activity.
Lesion detection at seven Tesla in multiple sclerosis using magnetisation prepared 3D-FLAIR and 3D-DIR (2011)

Near isotropic 3D-MP-FLAIR and 3D-MP-DIR allows high quality T2-weighted MR imaging in MS at 7 T, improving (cortical) lesion detection.
Characterization of passive permeability after low intensity focused ultrasound mediated blood–brain barrier disruption in a preclinical model (2022)

The magnitude of LiFUS mediated BBB opening correlates with concentration of microbubbles, cavitation dose as well as time of tracer administration post-sonication. These data help define the window of maximal BBB opening and applicable sonication parameters on a clinically translatable and commercially available FUS system that can be used to improve passive permeability and accumulation of therapeutics targeting the brain.
Meningitis and a safe dexamethasone-eluting intracochlear electrode array (2014)

The use of a dexamethasone-eluting intracochlear electrode array did not increase the risk of meningitis in rats when inoculated with S. pneumoniae via the middle ear 5 days following implantation.
Theoretical atom optics : evanescent wave atom optics and Bose-Einstein condensation (1999)

I am thankful to a great many people who helped me during the last three years, both with regards to my work as a physicist and in providing support,
The role of serum testosterone testing: routine hormone analysis is an essential part of the initial screening of men with erectile dysfunction. (2004)

As oral phosphodiesterase-5 inhibitor therapy has become the first-line treatment of erectile dysfunction (ED), common approaches in the evaluation of ED have been largely abandoned. Not only is routine hormone analysis no longer widely recommended, but most specialists perform serum testosterone level testing only in the most complex cases of ED. This article explores the rationale for including serum testosterone analysis as part of the initial screening of patients with ED. The use of routine serum testosterone testing is advocated for its efficacy in the diagnosis and treatment of hypogonadism and pituitary disorders associated with ED.
Mps3p is a novel component of the yeast spindle pole body that interacts with the yeast centrin homologue Cdc31p (2002)

Accurate duplication of the Saccharomyces cerevisiae spindle pole body (SPB) is required for formation of a bipolar mitotic spindle. We identified mutants in SPB assembly by screening a temperature-sensitive collection of yeast for defects in SPB incorporation of a fluorescently marked integral SPB component, Spc42p. One SPB assembly mutant contained a mutation in a previously uncharacterized open reading frame that we call MPS3 (for monopolar spindle). mps3-1 mutants arrest in mitosis with monopolar spindles at the nonpermissive temperature, suggesting a defect in SPB duplication. Execution point experiments revealed that MPS3 function is required for the first step of SPB duplication in G1. Like cells containing mutations in two other genes required for this step of SPB duplication (CDC31 and KAR1), mps3-1 mutants arrest with a single unduplicated SPB that lacks an associated half-bridge. MPS3 encodes an essential integral membrane protein that localizes to the SPB half-bridge. Genetic interactions between MPS3 and CDC31 and binding of Cdc31p to Mps3p in vitro, as well as the fact that Cdc31p localization to the SPB is partially dependent on Mps3p function, suggest that one function for Mps3p during SPB duplication is to recruit Cdc31p, the yeast centrin homologue, to the half-bridge.
A 2.4 GHz Fully Integrated Class-A Power Ampifier In 0.35&#956;m SiGe BiCMOS Technology (2006)

This paper presents a 2.4 GHz fully integrated class-A power amplifier designed and implemented in a commercial 0.35 mum SiGe BiCMOS technology for a single-chip dual-band transceiver. It delivers a power output of 18.5dBm at an input power of -8dBm with a PAE of 17%. The 2nd and 3rd harmonics are -37.5dBc and -32.2dBc, respectively. The power amplifier draws a DC current of 126mA from a 3.3 V supply and achieves a linear gain of 27.6 dB. The fabricated die size is only 1.2 mm times 1 mm. An improved PA model is introduced for optimal power matching analysis that was verified in this design
Using Aromatic Donor Acceptor Interactions to Affect Macromolecular Assembly (2006)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTUsing Aromatic Donor Acceptor Interactions to Affect Macromolecular AssemblyJoseph J. Reczek and Brent L. IversonView Author Information Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas Cite this: Macromolecules 2006, 39, 17, 5601–5603Publication Date (Web):July 29, 2006Publication History Received23 May 2006Revised13 July 2006Published online29 July 2006Published inissue 1 August 2006https://pubs.acs.org/doi/10.1021/ma0611669https://doi.org/10.1021/ma0611669rapid-communicationACS PublicationsCopyright © 2006 American Chemical SocietyRequest reuse permissionsArticle Views1584Altmetric-Citations66LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Aromatic compounds,Chemical structure,Fibers,Noncovalent interactions,Polymers Get e-Alerts
In Vitro and In Vivo Characterization of Three 68Ga- and 111In-Labeled Peptides for Cholecystokinin Receptor Imaging (2012)

Cholecystokinin (CCK) receptors are overexpressed in several human tumor types, such as medullary thyroid carcinomas and small cell lung cancers. Several ligands for the CCK2 receptor (CCK2R) have been developed for radionuclide targeting of these tumors. In this study, we evaluated whether radiolabeled DOTA-sCCK8 and its stabilized derivative, DOTA-sCCK8[Phe(2)(p-CH2SO3H), Nle(3,6)], are suitable for imaging of CCK2R-positive tumors, using DOTA-MG0 as a reference. In vivo targeting of CCK2R-positive tumors with DOTA-sCCK8, DOTA-sCCK8[Phe(2)(p-CH2SO3H), Nle(3,6)], and DOTA-MG0, labeled with (111)In or (68)Ga, was evaluated in BALB/c nude mice with a subcutaneous A431-CCK2R tumor. Biodistribution studies and single-photon emission computed tomography (SPECT) and positron emission tomography (PET) were performed at 1 hour postinjection. All peptides specifically accreted in the CCK2R-expressing tumors. Both (111)In-DOTA-sCCK8 and (111)In-DOTA-sCCK8[Phe(2)(p-CH2SO3H), Nle(3,6)] showed good tumor retention (4.65% ID/g and 5.44% ID/g, respectively, at 4 hours postinjection). On PET/computed tomographic (CT) and SPECT/CT scans, subcutaneous A431-CCK2R tumors were clearly visualized with low uptake of sCCK8 peptides in the intestines. Whereas radiolabeled DOTA-MG0 showed high kidney uptake (70% ID/g), the sCCK8 peptides showed low uptake in the kidneys. Sulfated CCK8 analogues combined high tumor uptake with low retention in the kidney and are therefore promising tracers for imaging of CCK2R-positive tumors.
A versatile approach to chiral macrocycles (2003)

Head-to-tail Heck coupling of units derived from amino alcohols and iodoaryl aldehydes provides a short and versatile route to non-racemic chiral macrocycles.
Outcome of Staphylococcus aureus Bacteremia According to Compliance with Recommendations of Infectious Diseases Specialists: Experience with 244 Patients (1998)

To determine whether recommendations of infectious diseases specialists affect outcome for patients, we evaluated 244 hospitalized patients with Staphylococcus aureus bacteremia. We offered our management recommendations to each patient's physicians and then assessed the clinical outcome for both patients for whom our consultative advice was followed and those for whom our advice was not heeded. All patients were followed up for 12 weeks after their first positive blood culture. Our management advice was followed for 112 patients (45.9%) and partially or completely ignored for 132 patients (54.1%). Patients for whom our recommendations were followed were more likely to be cured of their S. aureus infection and less likely to relapse (P < .01), despite having significantly more metastatic infections (P < .01) at the outset of therapy, than were those for whom our recommendations were not followed. Failure to follow recommendations to remove an infected intravascular device was the most important risk for treatment failure. After controlling for other factors, logistic regression analysis revealed that patients whose intravascular device was not removed were 6.5 times more likely to relapse or die of their infection than were those whose device was removed. Our findings suggest that patient-specific management advice by infectious diseases consultants can improve the clinical outcome for patients with S. aureus bacteremia.
Non-coding RNAs and Exosomes: Their Role in the Pathogenesis of Sepsis (2020)

Sepsis is characterized as an uncontrolled host response to infection, and it represents a serious health challenge, causing excess mortality and morbidity worldwide. The discovery of sepsis-related epigenetic and molecular mechanisms could result in improved diagnostic and therapeutic approaches, leading to a reduced overall risk for affected patients. Accumulating data show that microRNAs, non-coding RNAs, and exosomes could all be considered as novel diagnostic markers for sepsis patients. These biomarkers have been demonstrated to be involved in regulation of sepsis pathophysiology. However, epigenetic modifications have not yet been widely reported in actual clinical settings, and further investigation is required to determine their importance in intensive care patients. Further studies should be carried out to explore tissue-specific or organ-specific epigenetic RNA-based biomarkers and their therapeutic potential in sepsis patients.
Serially Biased Components for Digital-RF Receiver (2009)

Reduction of total bias current using the serial biasing technique is required for RSFQ-based digital-RF receiver realization. This will have a major impact on reducing the size, weight and power consumption of the complete cryocooled receiver system. The approach is based on partitioning a homogeneous design into several isolated islands biased in series and transmitting SFQ pulses between islands, over moats through inductively-coupled driver-receiver-pairs (DRPs). Experimental data on testing of 100 DRPs connected in series are reported and bit-error-rate estimates are given. Our goal is to serially bias two sets of homogeneous circuit blocks in the digital-RF receiver design: (1) digital decimation filter (DDF) bit slices, and (2) output drivers. The correct operation of test chips containing four bit-slices of a second-order DDF, partitioned into 2 and 4 islands, are demonstrated. Results of 8 output drivers, serially biased on 2, 4, and 8 islands, are reported. Design issues of scaling to a digital-RF receiver, containing 18-20 DDF bit slices and 16 output drivers are discussed.
Proof of Beat Entrainment and its Characteristics (2021)

Beat entrainment, an active synchronization between endogenous neural oscillations and rhythm stimuli, is a key element in various research fields, including attention selection, sensorimotor synchronization, speech and music. Various studies are under way on the beat entrainment, but it is still being discussed whether this brain response only reflects regular repetition of the events, or it includes entrained oscillatory activities. Nor is the mechanism and functional role of the beat entrainment known. The purpose of our study is to present evidence that the beat oscillation is inherently formed and to propose the functions and mechanisms of beat entrainment. The experiment was conducted in a sequence with 700ms of regular sound stimulus that had an amplitude cycle of `strong, weak, weak', containing some irregularly missing stimuli. Brain signal was measured using electrocorticography for epilepsy disease patients. As a result, significant neural oscillations were formed compared to the pre-stimulus section. Oscillations consist of 1.4286Hz oscillation dependent on all stimuli, as well as 0.4762Hz oscillation dependent only on strong stimuli. This demonstrate that the beat is characterized by its formation with weighting certain rhythm. The latencies of the response in each stimulus was identified differently. this can be evidence that beat entrainment is a procedure of endogenous brain response. And we suggest beat entrainment mechanism used to readjustment of beat entrainment and how brain percept different rhythm differently.
ChemInform Abstract: OXIDATION‐REDUCTION PROPERTIES OF MIXED OXIDES IN THE CERIUM‐URANIUM‐OXYGEN SYSTEM (1981)

Abstract Bildung und Redoxeigenschaften von Mischoxiden im ternären Titelsystem werden thermogravimetrisch und röntgenographisch untersucht.
Indentification of a CTC-based gene expression signature predicting resistance to abiraterone and enzalutamide in mCRPC. (2017)

5072 Background: Circulating tumor cell (CTC)-based detection of AR-V7 has been shown to be one potential marker for predicting response to 2nd generation androgen receptor (AR) therapies. However, the apparent rarity of AR-V7 positivity is indicative of the importance of other drivers of resistance in this setting. We sought to utilize a multiplex gene expression platform for assessing CTCs in order to determine other predictive biomarkers of response. Methods: Whole blood (~5mL) was obtained from 37 patients with mCRPC starting enzalutamide (n=16) or abiraterone (n=21). CTCs were isolated using anti-EpCAM-conjugated magnetic beads. Following cell lysis, mRNA was extracted followed by multiplex qRT-PCR for 92 prostate cancer-related genes. Samples were considered CTC-positive based on a previously established set of epithelial markers. We identified genes associated with PSA and radioclinical progression free survival (PFS) using Cox regression analysis. Muli-gene models were tested using ROC analysis. Results: We identified 20 patients (54%) with detectable CTCs, and patients were followed for a median of 10 months (IQR 3.9-19.4 months). Seven genes were associated with both PSA PFS and radioclinical PFS in the Cox analyses (Table). Combing the 7 genes into a single model gave AUC values of 0.88 for PSA PFS and 0.89 for radioclinical PFS. In comparison, the AR-V7-only model resulted in AUC values of 0.65 and 0.66. Conclusions: We identified seven prostate cancer-related genes that can be determined from CTCs and appear to predict short time to progression in men with mCRPC being treated with 2 nd generation hormonal therapies. While this is a small cohort and prospective validation is needed, these findings highlight the potential role for this approach in helping guide therapy choice. [Table: see text]
A TRANSCEIVER CONCEPT BASED ON A SOFTWARE DEFINED RADIO APPROACH (2006)

In this communication, a software defined radio (SDR) transceiver design, termed FALCON, will be presented. The FALCON is entirely based on a modular signal processing concept; the FALCON receiver uses modules which process and generate log-likelihood ratio (LLR) signals, hence, providing the capability of a plug-and-play-type re-configurability. The authors’ view on re-configurability will be discussed in this communication. The FALCON currently deploys commercial radio frequency (RF) front-ends provided by Atmel, analogue and interface boards developed and implemented by the authors and DSP Starter Kits (DSK) based on TI TMS320C6416 DSPs (digital signal processors), which have been provided by Texas Instruments. The hardware/software integration has been done in the laboratory of the authors. Furthermore, the authors developed all signal processing modules in C language tailored for the TMS320C6416 DSPs. This paper will also illustrate measurement results obtained with the FALCON will be given. For an easy comparison of these results with widely published simulation results the authors will consider UMTS/W-CDMA. It will be shown that the FALCON provides a superb performance.
Simultaneous-view correlation radiometer (2004)

A unique optical configuration of a Gas-Filter Correlation Radiometer (GFCR) is described. This configuration, known as a Simultaneous-View Correlation Radiometer (SVCR), was designed for surface-viewing nadir remote sensing of atmospheric trace gases in the near-infrared. It provides simultaneous measurement of both the gas-filter and correlation channels of the GFCR, minimising noise induced by geo-spatial variations in the surface reflectivity. We analyse the reduction in the sensitivity of the SVCR to noise in input radiance in comparison to a sequential gas-density state GFCR.
Supplementary Figure S3 from Preclinical Development of the Anti-LAG-3 Antibody REGN3767: Characterization and Activity in Combination with the Anti-PD-1 Antibody Cemiplimab in Human <i>PD-1xLAG-3</i>–Knockin Mice (2023)

&lt;p&gt;Supplementary Figure S3 shows blocking activity of anti-MHC class II antibody in in vitro assay&lt;/p&gt;
From Bioeconomics to Bioeconopysis in the Context of (Bio)Diversity and Modern Morality (2018)

The article develops a complex interdisciplinary paradigm, or rather a multiparadigm of bioeconomics, exemplifying the necessary role and the broader horizon of multidisciplinarity through bioeconophysics, in the context of (bio)diversity and modern morality, in a logically investigative and coherently summarized approach. A brief conceptual introduction is followed by the first section, dedicated to identifying the actual approach, going from scientific unidisciplinarity to modern multidisciplinarity, selecting and validating, out of the three hypotheses of plausible paths towards bioeconomics (BioEconoPhysics), Biophysical Economics or EconoBioPhysics, the one appropriately supported by arguments and historically motivated, but also because of the clarity of the methods and the consistency of the specific models. A second important section of the paper outlines the current context of (bio)diversity and morality, which is specific to bioeconomics, biophysics or econophysics, as well as the result of their interstitial or multidisciplinary unification, proving the usefulness of some detailed characteristic modern tendencies, relating to the opinions of, and relationships of science with ethics. Some final remarks and perspectives of econobiophysics or bioeconomics symmetrically close the outline of the article.
Pancreaticoduodenectomy (Whipple Resections) in Patients Without Malignancy (2003)

Pancreaticoduodenectomy (Whipple resection) has evolved into a safe procedure in major high-volume medical centers for the treatment of pancreatic adenocarcinoma and refractory chronic pancreatitis. However, some Whipple resections performed for a clinical suspicion of malignancy reveal only benign disease on pathologic examination. We evaluated the frequency of such Whipple resections without tumor in a large series of pancreaticoduodenectomies and classified the diverse pancreatic and biliary tract diseases present in these specimens. Of 442 Whipple resections performed during 1999-2001, 47 (10.6%) were negative for neoplastic disease and, in 40 cases, had been performed for a clinical suspicion of malignancy. Most Whipple resections revealed benign pancreatic disease, including 8 (17%) alcohol-associated chronic pancreatitis, 4 (8.5%) gallstone-associated pancreatitis, 1 (2.1%) pancreas divisum, 6 (12.8%) "ordinary" chronic pancreatitis of unknown etiology, and 11 (23.4%) lymphoplasmacytic sclerosing pancreatitis. In particular, patients with lymphoplasmacytic sclerosing pancreatitis were all thought to harbor malignancy, whereas only 13 of 19 (68.4%) of Whipple resections showing histologically "ordinary" forms of chronic pancreatitis were performed for a clinical suspicion of malignancy. Benign biliary tract disease, including three cases of primary sclerosing cholangitis, two cases of choledocholithiasis-associated chronic biliary tract disease, and four fibroinflammatory strictures isolated to the intrapancreatic common bile duct, was a common etiology for clinically suspicious Whipple resections (22.5% of cases). Pancreatic intraepithelial neoplasia (PanIN) was a common finding among all pancreata, whether involved by pancreatitis or histologically normal. Overall, PanIN 1A/1B was present in 68.1%, PanIN 2 in 40.4%, and PanIN 3 in just 2.1%. These findings indicate that "benign but clinically suspicious" Whipple resections are relatively common in high-volume centers (9.2%) and reveal a diverse group of clinicopathologically distinctive pancreatic and biliary tract disease.