gebhart/patrepeval huggingface dataset:
Hemorrhagic hypopyon as presenting feature of intravascular lymphoma, a case report (2017)

The exceedingly rare presentation of hemorrhagic hypopyon may have been enabled by an interaction of the HSV with the intravascular lymphoma. HSV involvement was indicated by the dendritic lesions, IgG assay, and response to anti-viral drugs. The ocular involvement of the intravascular lymphoma seems to be indicated by virtue of the anti-tumor drugs completely resolving all ocular symptoms.
Interocular correlation sensitivity and its relationship with stereopsis (2018)

Stereoscopic vision uses the disparity between the images received by the two eyes to derive three-dimensional estimates. Here, we were interested in providing a measure of the strength of binocular vision alternate to disparity processing. In particular, we wanted to assess the spatial dependence of sensitivity to detect interocular correlation (IOC). Thus we designed dichoptic stimuli composed of bandpass textures whose IOC is sinusoidally modulated at different correlation frequencies and compared sensitivity to these stimuli to that of analogous stimuli modulated in disparity. We observed that the IOC sensitivity is low pass/band pass and increases with stimulus duration and contrast in a similar way to that of disparity sensitivity. IOC sensitivity is only weakly, though significantly, correlated with disparity sensitivity in the population. It could provide an alternate measure of binocular sensitivity.
Revisiting QTL Affecting Clinical Mastitis by High-Density GWAS and Resequencing in the Finnish Ayrshire Dairy Cattle (2013)

Mastitis is the most common disease of dairy cattle, causing high economic losses each year. Studies to locate QTL affecting clinical mastitis and milk somatic cell counts have been carried out to increase our understanding of the disease. As part of the EU FP7 Quantomics project, we have used most recent genomic tools to characterize QTL affecting mastitis incidence in the Finnish Ayrshire cattle. Clinical mastitis diagnoses from -15 to 50 days and 51 to 300 days of first lactation and SCC (geometric mean of SCS observations between 5 to 170 days of first lactation) were included. In total, 1920 progeny tested bulls were genotyped with the Illumina BovineSNP50 chip. After quality control, 38473 SNPs were analyzed using a mixed linear model (software package DMU). Associations (5% Bonferroni threshold) were detected in 9 peaks on 5 chromosomes. A set of 238 of the bulls were re-genotyped with the BovineHD chip, and the remaining bulls imputed to high density genotypes using Beagle software. GWAS was repeated with the imputed HD-data with GRAMMAS (GenABEL in R). Thereby 17 peaks on 12 chromosomes were identified. Eight high priority peaks were defined based on both 50K and imputed HD results, and overlap with previous QTL findings. Eighteen ancestral Finnish Ayrshire bulls were sequenced to over 20X coverage, and this data was used to identify sequence variations in regions flanking 2.5 Mb each side of the high priority peaks. The variations were ranked according to estimated effect by a pipeline developed within the Quantomics project
Biodegradable Ethylene‐Bis(Propyl)Disulfide‐Based Periodic Mesoporous Organosilica Nanorods and Nanospheres for Efficient In‐Vitro Drug Delivery (2014)

Periodic mesoporous organosilica nanorods and nanospheres are synthesized from 1,4-bis(triethoxysilyl)ethylene and bis(3-ethoxysilylpropyl)disulfide. The nanosystems present the long-range order of the hexagonal nanostructure. They are degraded in simulated physiological conditions. The loading and release of doxorubicin with these nanosystems are both pH dependent. These nanoparticles are endocytosed by breast cancer cells and are very efficient for doxorubicin delivery in these cells.
Reifung von Proben beeinflusst die Effizienz der Kernpolarisation (2018)

Abstract Mischungen von Wasser und Glycerin sind populäre Matrizen für die Tieftemperaturspektroskopie verglaster Proben. Allerdings besitzen solche Mischungen konterintuitive Eigenschaften, wie spontane Nanophasenseparation in Lösungen, die makroskopisch homogen scheinen. Wir zeigen hier, dass solche Phänomene die Effizienz der dynamischen Kernpolarisation stark beeinflussen können, durch Fluktuation der lokalen Konzentration der Polarisationsmittel (Radikale) um bis zu 20 %. Spontane Nanophasenseparationen, die auf Zeitskalen von 30–60 min stattfinden, resultieren in lokalen wasserreichen Einschlüssen mit erhöhter Radikalkonzentration. Solche Phänomene wurden für die drei häufigen Polarisationsmittel TEMPOL, AMUPol und Trityl beobachtet.
Processing of tetanus toxin by human antigen-presenting cells. Evidence for donor and epitope-specific processing pathways. (1989)

Human T cell clones specific for epitopes 830-843 and 947-967 of tetanus toxin can be differentially activated in vitro when APC (PBL or LCL) from different donors are pulsed with tetanus toxin. Although PBL tested do not seem to exhibit substantial differences in the number of precursor T cells specific for these epitopes, APC from the same donors activate clone KT-2 specific for peptide 830-843 but not clone KT-30 specific for peptide 947-967. These APC express the proper restriction element because they can present the corresponding synthetic peptides. The failure to present a particular epitope might, however, be explained by the absence or presence of a protease(s) required for Ag presentation that may vary for different epitopes. Indeed, the protease inhibitor leupeptin was found to inhibit activation of KT-2 but not KT-30 T cell clone by the KK.35 B cell line normally capable of presenting either epitope. In summary, these data suggest that tetanus toxin processing and epitope formation by APC is distinct in different donors and for different epitopes.
Rhesus Theta-Defensin Prevents Death in a Mouse Model of Severe Acute Respiratory Syndrome Coronavirus Pulmonary Disease (2009)

We evaluated the efficacy of rhesus theta-defensin 1 (RTD-1), a novel cyclic antimicrobial peptide, as a prophylactic antiviral in a mouse model of severe acute respiratory syndrome (SARS) coronavirus (CoV) lung disease. BALB/c mice exposed to a mouse-adapted strain of SARS-CoV demonstrated 100% survival and modest reductions in lung pathology without reductions in virus titer when treated with two intranasal doses of RTD-1, while mortality in untreated mice was approximately 75%. RTD-1-treated, SARS-CoV-infected mice displayed altered lung tissue cytokine responses 2 and 4 days postinfection compared to those of untreated animals, suggesting that one possible mechanism of action for RTD-1 is immunomodulatory.
Intracellular sodium and lithium NMR relaxation times in the perfused frog heart (1987)

We have used a combination of a shift reagent and mathematical filtering or presaturation of the extracellular sodium resonance for the quantitative investigation of the intracellular sodium and lithium relaxation times in the perfused frog heart. While the T1 of the intracellular sodium was found to consist of a single-exponential time constant (approximately 23 ms), the T2 was better fit as a double-exponential decay with time constants of approximately 2 and 17 ms. However, the relative amplitudes of the two time constants in the T2 decay were found to be inconsistent with those which would be expected from a homogeneous pool of nuclei undergoing quadrupolar interactions. The relaxation times were not changed by a fivefold increase in the intracellular sodium level (due to perfusion with a ouabain-containing buffer). The T1 and T2 of the intracellular lithium (after perfusion with lithium-containing buffer) were both well fit by single exponentials (700- and 31-ms time constants, respectively).
Disruption ofmetFIncreased L-Lysine Production byMethylophilus methylotrophusfrom Methanol (2008)

Methionine auxotrophic mutants of Methylophilus methylotrophus AS1 expressing a mutant form of dapA (dapA24) encoding a dihydrodipicolinate synthase desensitized from feedback inhibition by L-lysine, and mutated lysE (lysE24) encoding the L-lysine exporter from Corynebacterium glutamicum 2256, produced higher amounts of L-lysine from methanol as sole carbon source than did other amino acid auxotrophic mutants. Especially, the M. methylotrophus 102 strain, carrying both dapA24 and lysE24, produced L-lysine in more than 1.5 times amounts higher than the parent. A single-base substitution was identified in this auxotroph in codon-329 of the open reading frame of metF, encoding 5,10-methylene-tetra-hydrofolate reductase. We constructed a metF disruptant mutant carrying both dapA24 and lysE24, and confirmed increases in L-lysine production. This is the first report to the effect that metF deficient increased L-lysine production in methylotroph.
Process Robustness of Laser Braze-Welded Al/Cu Connectors (2016)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;Laser welding of dissimilar metals such as Aluminum and Copper, which is required for Li-ion battery joining, is challenging due to the inevitable formation of the brittle and high electrical-resistant intermetallic compounds. Recent research has shown that by using a novel technology, called laser braze-welding, the Al-Cu intermetallics can be minimized to achieve superior mechanical and electrical joint performance. This paper investigates the robustness of the laser braze-welding process. Three product and process categories, i.e. choice of materials, joint configurations, and process conditions, are studied. It is found that in-process effects such as sample cleanness and shielding gas fluctuations have a minor influence on the process robustness. Furthermore, many pre-process effects, e.g. design changes such as multiple layers or anodized base material can be successfully welded by process adaption. The minimization of the interface gap is identified as the most significant influence of process stability. The specimen were validated by mechanical lap shear tests and metallographic analysis.&lt;/div&gt;&lt;/div&gt;
Linear chirp parameter estimation from multichannel data (2003)

In most multichannel models, narrowband signals are assumed transmitted, and existing algorithms for parameter estimation are based on this assumption. Here we exploit the wideband properties of a linear chirp signal to make common direction of arrival estimators more efficient. In addition to direction of arrival, linear chirp parameters are estimated. We propose a suboptimal two step algorithm for joint direction of arrival and chirp parameter estimation. Performance is evaluated on synthetic data. Further experimental data are available to complement the theory.
Electronic clinical decision support algorithms incorporating point-of-care diagnostic tests in low-resource settings: a target product profile (2020)

Health workers in low-resource settings often lack the support and tools to follow evidence-based clinical recommendations for diagnosing, treating and managing sick patients. Digital technologies, by combining patient health information and point-of-care diagnostics with evidence-based clinical protocols, can help improve the quality of care and the rational use of resources, and save patient lives. A growing number of electronic clinical decision support algorithms (CDSAs) on mobile devices are being developed and piloted without evidence of safety or impact. Here, we present a target product profile (TPP) for CDSAs aimed at guiding preventive or curative consultations in low-resource settings. This document will help align developer and implementer processes and product specifications with the needs of end users, in terms of quality, safety, performance and operational functionality. To identify the characteristics of CDSAs, a multidisciplinary group of experts (academia, industry and policy makers) with expertise in diagnostic and CDSA development and implementation in low-income and middle-income countries were convened to discuss a draft TPP. The TPP was finalised through a Delphi process to facilitate consensus building. An agreement greater than 75% was reached for all 40 TPP characteristics. In general, experts were in overwhelming agreement that, given that CDSAs provide patient management recommendations, the underlying clinical algorithms should be human-interpretable and evidence-based. Whenever possible, the algorithm's patient management output should take into account pretest disease probabilities and likelihood ratios of clinical and diagnostic predictors. In addition, validation processes should at a minimum show that CDSAs are implementing faithfully the evidence they are based on, and ideally the impact on patient health outcomes. In terms of operational needs, CDSAs should be designed to fit within clinic workflows and function in connectivity-challenged and high-volume settings. Data collected through the tool should conform to local patient privacy regulations and international data standards.
Computing global minimizers to a constrained B‐spline image registration problem from optimal l1 perturbations to block match data (2014)

The proposed methodology is demonstrated to achieve a high spatial accuracy and is generalizable in that in can employ any displacement field parameterization described as a least squares fit to block match generated estimates. Thus, the framework allows for a wide range of image similarity block match metric and physical modeling combinations.
Novel Radioiodinated Aurones as Probes for SPECT Imaging of β-Amyloid Plaques in the Brain (2008)

We report a novel series of radioiodinated aurone derivatives as probes for imaging Abeta plaques in the brains of patients with Alzheimer's disease (AD) using single photon emission computed tomography (SPECT). In binding experiments in vitro, aurone derivatives showed very good affinity for Abeta aggregates (K(i) = 1.1 to 3.4 nM). No-carrier-added radioiodinated aurones were successfully prepared through an iododestannylation reaction from the corresponding tributyltin derivatives. In biodistribution experiments using normal mice, aurone derivatives displayed high brain uptake (1.7-4.5% ID/g at 2 min) and rapid clearance from the brain (0.1-0.4% ID/g at 30 min), especially [125I]15. Furthermore, a specific plaque labeling signal was observed in in vitro autoradiography of postmortem AD brain sections using [125I]15. [125I]15 may be a useful SPECT imaging agent for detecting Abeta plaques in the brain of AD.
Measurement of differential cross sections for Higgs boson production in the diphoton decay channel in pp collisions at $$\sqrt{s}=8\,\text {TeV} $$ s = 8 TeV (2016)

A measurement is presented of differential cross sections for Higgs boson (H) production in pp collisions at [Formula: see text][Formula: see text]. The analysis exploits the [Formula: see text] decay in data corresponding to an integrated luminosity of 19.7[Formula: see text] collected by the CMS experiment at the LHC. The cross section is measured as a function of the kinematic properties of the diphoton system and of the associated jets. Results corrected for detector effects are compared with predictions at next-to-leading order and next-to-next-to-leading order in perturbative quantum chromodynamics, as well as with predictions beyond the standard model. For isolated photons with pseudorapidities [Formula: see text], and with the photon of largest and next-to-largest transverse momentum ([Formula: see text]) divided by the diphoton mass [Formula: see text] satisfying the respective conditions of [Formula: see text] and [Formula: see text], the total fiducial cross section is [Formula: see text][Formula: see text].
Microfluidic Preparative Free-Flow Isoelectric Focusing: System Optimization for Protein Complex Separation (2010)

Isoelectric focusing (IEF) is the first step for two-dimensional (2D) gel electrophoresis and plays an important role in sample purification for proteomics. However, biases in protein size and pI resolution, as well as limitations in sample volume, gel capacity, sample loss, and experimental time, remain challenges. In order to address some of the limitations of traditional IEF, we present a microfluidic free flow IEF (FF-IEF) device for continuous protein separation into 24 fractions. The device reproducibly establishes a nearly linear pH gradient from 4 to 10. Optimized dynamic coatings of 4% poly(vinyl alcohol) (PVA) minimize peak broadening by transverse electrokinetic flows. Even though the device operates at high electric fields (up to 370 V/cm), efficient cooling maintains solution temperature inside the separation channel controllably in the range 2-25 degrees C. Protein samples with a dynamic concentration range from microg/mL to mg/mL can be loaded into the microdevice at a flow rate of 1 mL/h and residence time of approximately 12 min. By using a protein complex of nine proteins and 13 isoforms, we demonstrate improved separation with the FF-IEF system over traditional 2D gel electrophoresis. Device-to-device reproducibility is also illustrated through the efficient depletion of the albumin and hemoglobin assays. Post-device sample concentrations result in a 10-20-fold increase, which allow for isolation and detection of low abundance proteins. The separation of specific proteins from a whole cell lysate is demonstrated as an example. The microdevice has the further benefits of retaining high molecular weight proteins, providing higher yield of protein that has a broader range in pI, and reducing experimental time compared to conventional IEF IGP gel strip approaches.
Design and optimisation of RF filters for multistandard RF sub-sampling receiver (2006)

This paper presents an improved sampling-based down conversion topology design with double RF filters for multi-standard RF subsampling receiver. Proposed architecture is limiting down conversion to IF domain and adding a first tunable RF filter to select multistandard RF bands. To overcome subsampling negative effects on receiver performances a second RF filter is inserted before subsampling operation to perform anti-aliasing and limit wide band noise. RF filters design methodology and ADS simulation results are presented for GSM, UMTS and IEEE-802.11g standards. Good performance improvement is obtained with reduced complexity architecture and circuits
Static and dynamic behavior of saturation-induced saliencies and their effect on carrier signal based sensorless AC drives (2002)

This paper analyzes the origin and the behavior of saturation-induced saliencies in induction machines, and their influence on carrier signal injection based sensorless techniques. The modeling of saturation-induced saliencies is necessary for the estimation of flux position, while the minimization of their influence is desired for the estimation of rotor position. Specifically focusing on rotor position estimation, there are two ways to achieve this minimization, the first being the use of a machine design that reduces the magnitude of the undesired saturation-induced saliencies and the second being the compensation in the estimator of the undesired saturation-induced saliencies. The modeling of saturation-induced saliencies, not only statically, but also dynamically, i.e. when the operating point of the machine changes, is addressed by this paper.
LESS-VFL: Communication-Efficient Feature Selection for Vertical Federated Learning (2023)

We propose LESS-VFL, a communication-efficient feature selection method for distributed systems with vertically partitioned data. We consider a system of a server and several parties with local datasets that share a sample ID space but have different feature sets. The parties wish to collaboratively train a model for a prediction task. As part of the training, the parties wish to remove unimportant features in the system to improve generalization, efficiency, and explainability. In LESS-VFL, after a short pre-training period, the server optimizes its part of the global model to determine the relevant outputs from party models. This information is shared with the parties to then allow local feature selection without communication. We analytically prove that LESS-VFL removes spurious features from model training. We provide extensive empirical evidence that LESS-VFL can achieve high accuracy and remove spurious features at a fraction of the communication cost of other feature selection approaches.
SerumandNasal-Wash Immunoglobulin G andA Antibody Response ofInfants andChildren toRespiratory Syncytial VirusF andG Glycoproteins Following Primary Infection (1986)

fusion (F)or attachment (G) glycoprotein was usedtomeasuretheserum andsecretory immuneresponsesof18infants andchildren, 4to 21monthsofage,whounderwent primary infection withrespiratory syncytial virus (RSV). Mostofthe10 older individuals (9to21monthsofage)developed moderate levels ofserum andnasal-wash immunoglobin A (IgA) andIgGF andG antibodies. Theseindividuals developed a moderate level ofserum or nasal-wash antibodies that neutralized virus infectivity. Oneoftheeight youngerindividuals (4to8monthsofage)failed todevelop an F antibody response,while three failed todevelop a G antibody response.Themostnotable difference intheresponsesofthetwoagegroupsinvolved thetiter inconvalescent seraofG,F,andneutralizing antibodies which were 8-to10-fold lower inyoungerindividuals. Mostoftheyoungerinfants failed todevelop a rise inserum or nasal-wash neutralizing antibody. Itispossible thatthepresenceofmaternally derived antibody intheyoungerinfants suppressed theimmuneresponsetoRSVinfection, andthatthis accounted, in part, forthelowlevel ofpostinfection antibody titer inthis group.Thislowlevel andtheirregular responseof theinfants less than8monthsofage may contribute totheseverity oftheir initial infection andmay alsobe responsible, inpart,fortheir failure todevelop effective resistance tosubsequent reinfection byRSV. Respiratory syncytial virus (RSV), whichbelongs tothe pneumovirus subgroup oftheParamyxoviridae family, isthe leading cause ofseverelowerrespiratory tractdisease in infancy (14, 15,23). RSVisanonsegmented negative-strand RNA virus thatcodesforatleast 10distinct gene products (7). Twoofthese arevirion-associated glycoproteins with