gebhart/patrepeval huggingface dataset:
P1–327: Memory performance of past public events depends on retrieval frequency but not remoteness in Alzheimer's disease (2013)

Patients with Alzheimer's disease (AD) typically develop retrograde amnesia. But whereas some studies found a better preservation of older memories than more recent ones, others could not detect such a temporal gradient (TG). Therefore the views of involvement of the in AD early affected hippocampus in the storage and retrieval of declarative knowledge are ambiguous. In two previous studies we investigated autobiographical memory and remembrance of historic events in patients with AD. While we could show a clear TG in recall of autobiographical information, we did not find a TG for knowledge concerning public events in the same patients with AD. We concluded that recall of more frequently retrieved memories as older autobiographical incidents becomes more independent of the hippocampal formation than more seldomly retrieved remembrances. Consequently, we investigated memory retrieval of past public events in patients with AD in dependency of retrieval frequency with functional magnetic resonance imaging (fMRI). In 28 healthy controls (HC) and 26 patients with AD we assessed the remembrance of historic events of the last 60 years divided in 4 time segments. Retrieval frequency was operationalized by a paired comparison analysis. The events were matched head-to-head with each other and the subjects were required to estimate which of the two events was more often remembered during lifetime. In the scanner an imagination task was chosen as control task. As well for the HC group as for the patients with AD we could show a better remembrance of frequently retrieved historic events. No influence of time segment was found. Neuronal network of memory of historic events comprised hippocampus, parts of the medial temporal cortex, precuneus, gyrus angularis and medial prefrontal cortex. Brain activity in this network was reduced in AD. In both groups activity in hippocampus and precuneus increased with retrieval frequency but did not differ with time period. The results of the present study suggest a dependency of memory performance on retrieval frequency accompanied by enhancement of brain activity in hippocampus and precuneus in HC and AD. Thus, we conclude that cognitive activities can delay the onset of memory decline in persons who develop AD.
Structure and function of archaeal prefoldin, a co-chaperone of group II chaperonin (2009)

Molecular chaperones are key cellular components involved in the maintenance of protein homeostasis and other unrelated functions. Prefoldin is a chaperone that acts as a co-factor of group II chaperonins in eukaryotes and archaea. It assists proper folding of protein by capturing nonnative proteins and delivering it to the group II chaperonin. Eukaryotic prefoldin is a multiple subunit complex composed of six different polypeptide chains. Archaeal prefoldin, on the other hand, is a heterohexameric complex composed of two alpha and four beta subunits, and forms a double beta barrel assembly with six long coiled coils protruding from it like a jellyfish with six tentacles. Based on the structural information of the archaeal prefoldin, substrate recognition and prefoldin-chaperonin binding mechanisms have been investigated. In this paper, we review a series of studies on the molecular mechanisms of archaeal PFD function. Particular emphasis will be placed on the molecular structures revealed by X-ray crystallography and molecular dynamics induced by binding to nonnative protein substrates.
The Crystal and Molecular Structure of the Photodimer of Biphenylene (1981)

Abstract The molecular structure of the photodimer of biphenylene has been determined by X-ray crystal analysis. The crystals are triclinic, with eight molecules in a unit cell with dimensions of a=15.061, b=17.687, c=13.091 Å, α=108.91, β=98.52, and γ=89.71°; the space group is P\bar1. 6625 unique intensity data were collected on a four-circle diffractometer with LiF-monochromated Cu Kα radiation. The structure was solved by the symbolic-addition method using 8 symbols, and refined by the block-diagonal least-squares method. The final R value was 0.101. The molecular structure thus obtained corresponds to syn-13,14 : 15,16-dibenzotricyclo[6.4.2.22,7]hexadeca-1,3,5,7,9,11,13,15-octaene. Of the four crystallographically-independent molecules, two have approximately the C2v symmetry, while the remaining two are somewhat deformed, their symmetry being nearly C2. The molecules are held together mainly by van der Waals interactions.
The androgenic regulation of prostate proteins with a high affinity for deoxyribonucleic acid. Evidence for a prostate deoxyribonucleic acid-unwinding protein (1976)

1. When testosterone is injected into castrated rats in vivo, a significant increase in the incorporation of [35S]methionine into prostate proteins may be detected under conditions in vitro. 2. Studies based on DNA-cellulose chromatography show that the synthesis of prostate proteins with a high affinity for DNA is particularly enhanced by androgenic stimulation. 3. These changes in protein synthesis are negated when the anti-androgen, cyproterone acetate, is administered concomitantly with testosterone in vivo. 4. Two assays were developed for measuring the strand separation of prostate DNA; first, the retention of 3H-labelled native DNA on nitrocellulose membranes, and second, the activation of native DNA as a template for 9S prostate DNA polymerase. On the basis of these criteria, DNA-unwinding activity is present in the prostate gland and it is regulated by androgens in a steroid-and tissue-specific manner. 5. The results are discussed in the context of the mechanism of action of androgens, particularly since the changes provoked in DNA-unwinding activity by androgens precede the onset of DNA replication and mitosis.
Supplementary Figure 3 from A First-in-Human Phase I Study of INVAC-1, an Optimized Human Telomerase DNA Vaccine in Patients with Advanced Solid Tumors (2023)

&lt;p&gt;Immunophenotyping of circulating CD4 and CD8 T cells&lt;/p&gt;
Flare Phenomenon in O-(2-18F-Fluoroethyl)-l-Tyrosine PET After Resection of Gliomas (2020)

PET using <i>O</i>-(2-<sup>18</sup>F-fluoroethyl)-l-tyrosine (<sup>18</sup>F-FET) is useful to detect residual tumor tissue after glioma resection. Recent animal experiments detected reactive changes in <sup>18</sup>F-FET uptake at the rim of the resection cavity within the first 2 wk after resection of gliomas. In the present study, we evaluated pre- and postoperative <sup>18</sup>F-FET PET scans of glioma patients with particular emphasis on the identification of reactive changes after surgery. <b>Methods:</b> Forty-three patients with cerebral gliomas (9 low-grade, 34 high-grade; 9 primary tumors, 34 recurrent tumors) who had preoperative (time before surgery: median, 23 d; range, 6-44 d) and postoperative <sup>18</sup>F-FET PET (time after surgery: median, 14 d; range, 5-28 d) were included. PET scans (20-40 min after injection) were evaluated visually for complete or incomplete resection and compared with MRI. Changes in <sup>18</sup>F-FET uptake were evaluated by tumor-to-brain ratios in residual tumor and by maximum lesion-to-brain ratios near the resection cavity. <b>Results:</b> Visual analysis of <sup>18</sup>F-FET PET scans revealed complete resection in 16 of 43 patients and incomplete resection in the remaining patients. PET results were concordant with MRI in 69% of the patients. The maximum lesion-to-brain ratio for <sup>18</sup>F-FET uptake near the resection cavity was significantly higher than preoperative values (1.59 ± 0.36 vs. 1.14 ± 0.17; <i>n</i> = 43; <i>P</i> < 0.001). In 11 patients (26%), a flare phenomenon was observed, with a considerable increase in <sup>18</sup>F-FET uptake compared with preoperative values in either the residual tumor (<i>n</i> = 5) or areas remote from the tumor on the preoperative PET scan (<i>n</i> = 6) (2.92 ± 1.24 vs. 1.62 ± 0.75; <i>P</i> < 0.001). Further follow-up in 5 patients showed decreasing <sup>18</sup>F-FET uptake in the flare areas in 4 patients and progress in 1 patient. <b>Conclusion:</b> Our study confirmed that <sup>18</sup>F-FET PET provides valuable information for assessing the success of glioma resection. Postoperative reactive changes at the rim of the resection cavity appear to be mild. However, in 23% of the patients, a postoperative flare phenomenon was observed that warrants further investigation.
Apparatus and process for separating hydrogen isotopes (2023)

The apparatus and process for separating hydrogen isotopes is provided using dual columns, each column having an opposite hydrogen isotopic effect such that when a hydrogen isotope mixture feedstock is cycled between the two respective columns, two different hydrogen isotopes are separated from the feedstock.
Laser à semiconducteur en cavité externe bipolarisé et bifréquence pour les horloges atomiques (2011)

Nous décrivons l'émission simultanée en phase sur deux fréquences optiques polarisées perpendiculairement d'un laser à semiconducteur en cavité externe pompé optiquement. L'émission est accordable autour de la raie D2 du césium à 852,14 nm. La puissance optique est d'environ 10 mW sur chaque polarisation.
120 * ULTRASOUND-ASSISTED TREATMENT OF STERNOCUTANEOUS FISTULA IN POSTSTERNOTOMY CARDIAC SURGERY PATIENTS (2014)

Objectives: Using an ultrasonic debridement system, we aimed at complete removal of bacterial biofilms and preservation of vital sternal tissue, and compared the procedure to conventional surgical therapy. Methods: In this retrospective study, we evaluated 37 consecutive patients (25 male) between April 2011 and June 2013, in whom sternocutaneous fistula (SCF) was treated with the ultrasound-assisted wound system (UAW, group A, n = 18) or with conventional surgical therapy (group B, n = 19). Treatment in group A consisted of complete dissection of SCF followed by a multistep UAW debridement session. Our final step in both groups was secondary wound closure with a musculocutaneous flap. Results: Most patients were categorised as high risk, presenting with several of the known risk factors. In both groups, a similar variety of microorganisms were isolated: 61% of Gram-positive, 16.5% Gram-negative species and 10.5% Candida albicans were detected. Time to eradication and secondary wound closure was significantly shorter in group A (9.8 ± 5.4 vs 12.2 ± 17.2 days, P = 0.0118). Postoperative antibiotic treatment time (16.4 ± 9.3 vs 22.4 ± 10.7 days, P = 0.0779) showed a trend in favour of group A, mean hospitalisation time (22.2 ± 12.0 vs 26.4 ± 14.3 days, P = 0.3412) did not differ between groups. Recurrence of SCF tended to be lower in group A (5.5% vs 21% in group B, P = 0.3398). In group B, one infection-related death was noted. Mean follow-up time was 7.7 ± 2.7 (A) and 9.8 ± 5.7 months (B). Conclusion: Ultrasonic debridement is a promising adjunct to SCF treatment. In combination with adequate surgical and antimicrobial therapy, we documented good mid-term results in our trial group.
Selective and Efficient Synthesis of Cyclic Hexakis(thio-1,4-phenylene) through Oxidative Polymerization of Diphenyl Disulfide (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTSelective and Efficient Synthesis of Cyclic Hexakis(thio-1,4-phenylene) through Oxidative Polymerization of Diphenyl DisulfideKenji Miyatake, Yoshihiro Yokoi, Kimihisa Yamamoto, Eishun Tsuchida, and Allan S. HayView Author Information Department of Polymer Chemistry, Advanced Research Institute for Science and Engineering, Waseda University, Tokyo 169, Japan Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 2K6, Canada Cite this: Macromolecules 1997, 30, 15, 4502–4503Publication Date (Web):July 28, 1997Publication History Received27 November 1996Revised4 April 1997Published online28 July 1997Published inissue 1 July 1997https://pubs.acs.org/doi/10.1021/ma961740ohttps://doi.org/10.1021/ma961740orapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views451Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Aromatic compounds,Disulfides,Hydrocarbons,Oligomers,Substitution reactions Get e-Alerts
Distributed fiber-optic intrusion sensor system (2005)

A distributed sensor system for detecting and locating intruders based on the phase-sensitive optical-time-domain reflectometer (/spl phi/-OTDR) is described. The sensing element is a cabled single-mode telecommunications fiber buried along the monitored perimeter. Light pulses from a continuous-wave Er:fiber Fabry-Pe/spl acute/rot laser with a narrow (/spl ap/3 kHz) instantaneous linewidth and low (few kilohertz per second) frequency drift are injected into one end of the fiber, and the backscattered light is monitored with a photodetector. The effect of phase changes resulting from the pressure of the intruder on the ground immediately above the buried fiber are sensed by subtracting a /spl phi/-OTDR trace from an earlier stored trace. In laboratory tests with fiber on reels, the effects of localized phase perturbations induced by a piezoelectric fiber stretcher on /spl phi/-OTDR traces were observed. In field tests, people walking on the ground above a buried fiber cable induced phase shifts of several-/spl pi/ radians.
Supplementary Tables 1 - 2, Figure 1 from Adaptive Prediction Model in Prospective Molecular Signature–Based Clinical Studies (2023)

&lt;p&gt;PDF file - 47K, Table S1. Simulation settings, Table S2. Biological verification of genes with high adaptive scores, Figure S1. ROC curves in the simulation study.&lt;/p&gt;
hrpF of Xanthomonas campestris pv. vesicatoria Encodes an 87-kDa Protein with Homology to NolX of Rhizobium fredii (1997)

The gram-negative bacterium Xanthomonas campestris pv. vesicatoria is the causal agent of bacterial spot disease on pepper and tomato plants. The main hrp (hypersensitive reaction and pathogenicity) gene cluster in X. campestris pv. vesicatoria spans a 23-kb chromosomal region, comprising six complementation groups designated hrpA to hrpF. Analysis of the hrpF locus revealed a single open reading frame encoding HrpF (86.4 kDa). HrpF is predominantly hydrophilic, and contains two hydrophobic domains in the C terminus. An interesting feature is the presence of two imperfect direct repeats in the N-terminal region. Deletion studies showed that one repeat is sufficient for function. Epitope tagging of HrpF allowed detection of the protein in X. campestris pv. vesicatoria. Subcellular localization studies suggest that HrpF is both in the soluble fraction and in the inner membrane. Interestingly, HrpF is 48% identical (67% similar) to the Rhizobium fredii NoIX protein that is part of the host specificity locus. Since several Hrp proteins are believed to be components of the types of III hrp protein secretion apparatus, allowing export of proteins essential for the interaction with the plant, the possible role of hrpF and NoIX in secretion is discussed.
Statistical properties of a short analog RF free-space optical link (2009)

Free-space optical (FSO) links typically carry digital data over short to moderate distances (100m - 50 km). From a military perspective, FSO links have the advantages of low probability of interception, inherent anti-jam capability and a reasonable degree of covertness. In certain applications it is desirable to minimize size, weight and power of the transmitter and this pushes the designer to eliminate power-hungry digitizers and to transmit raw analog, instead of digital, information. However, the transmission of analog signals presents significant technical challenges due to strong fluctuations in received optical power resulting from atmospheric turbulence. In this case the standard RF link properties of gain, noise factor, and linearity must be described entirely in statistical terms. In this paper we present preliminary experimental results from a short (500m), single-tone, 5 MHz analog FSO link and compare the data to theoretical predictions. Theory suggests, and our preliminary experimental results confirm, that the statistical properties of all the RF performance metrics of a FSO analog link are determined entirely by the statistical properties of the received optical power. We show that the distribution of values of RF link parameters can be obtained directly from the distribution of received optical power, without the need for modeling the received power with a continuous function.
Long-Term EEG Monitoring in Patients with Alzheimer’s Disease Using Ear-EEG: A Feasibility Study (2022)

It is feasible and safe to use ear-EEG for long-term EEG monitoring in patients with AD. Minor adjustments to the equipment may improve the comfort for the participants.
Pseudo-Peptides in Drug Discovery Edited by Peter E. Nielsen. Wiley-VCH, Weinheim, Germany. 2004. xiii + 244 pp. 17.5 × 24.5 cm. ISBN 3527306331. $125.00. (2005)

ADVERTISEMENT RETURN TO ISSUEPREVBook ReviewNEXTPseudo-Peptides in Drug Discovery Edited by Peter E. Nielsen. Wiley-VCH, Weinheim, Germany. 2004. xiii + 244 pp. 17.5 × 24.5 cm. ISBN 3527306331. $125.00.Victor J. HrubyView Author Information Department of Chemistry University of Arizona Tucson, Arizona 85721Cite this: J. Med. Chem. 2005, 48, 8, 3090–3091Publication Date (Web):March 11, 2005Publication History Published online11 March 2005Published inissue 21 April 2005https://pubs.acs.org/doi/10.1021/jm0581765https://doi.org/10.1021/jm0581765book-reviewACS PublicationsCopyright © 2005 American Chemical SocietyRequest reuse permissionsArticle Views169Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Amides,Genetics,Monomers,Nucleic acids,Peptides and proteins Get e-Alerts
Les tensioactifs biosourcés Du laboratoire à l'échelle industrielle [Biosourced surfactants From the lab to the industrial scale] (2018)

National audience
Data from Involvement of Epigenetics and EMT-Related miRNA in Arsenic-Induced Neoplastic Transformation and Their Potential Clinical Use (2023)

&lt;div&gt;Abstract&lt;p&gt;Exposure to toxicants leads to cumulative molecular changes that overtime increase a subject's risk of developing urothelial carcinoma. To assess the impact of arsenic exposure at a time progressive manner, we developed and characterized a cell culture model and tested a panel of miRNAs in urine samples from arsenic-exposed subjects, urothelial carcinoma patients, and controls. To prepare an &lt;i&gt;in vitro&lt;/i&gt; model, we chronically exposed an immortalized normal human bladder cell line (HUC1) to arsenic. Growth of the HUC1 cells was increased in a time-dependent manner after arsenic treatment and cellular morphology was changed. In a soft agar assay, colonies were observed only in arsenic-treated cells, and the number of colonies gradually increased with longer periods of treatment. Similarly, invaded cells in an invasion assay were observed only in arsenic-treated cells. Withdrawal of arsenic treatment for 2.5 months did not reverse the tumorigenic properties of arsenic-treated cells. Western blot analysis demonstrated decreased PTEN and increased AKT and mTOR in arsenic-treated HUC1 cells. Levels of miR-200a, miR-200b, and miR-200c were downregulated in arsenic-exposed HUC1 cells by quantitative RT-PCR. Furthermore, in human urine, miR-200c and miR-205 were inversely associated with arsenic exposure (&lt;i&gt;P&lt;/i&gt; = 0.005 and 0.009, respectively). Expression of miR-205 discriminated cancer cases from controls with high sensitivity and specificity (AUC = 0.845). Our study suggests that exposure to arsenic rapidly induces a multifaceted dedifferentiation program and miR-205 has potential to be used as a marker of arsenic exposure as well as a maker of early urothelial carcinoma detection. &lt;i&gt;Cancer Prev Res; 8(3); 208–21. ©2015 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Bone Marrow Microvessel Density and it's Prognostic Significance in AML (2004)

Microvessel density reportedly is increased in various hematologic disorders including acute lymphatic and myeloid leukemias. In these patients the bone marrow microvessel density (BM-MVD) appears to be associated with an unfavorable prognosis. In the present study, we have retrospectively analyzed the BM-MVD (at diagnosis) in 31 patients with acute myeloid leukemia (AML) (median age: 38 years; range: 21-53 years; f:m-ratio: 1:1,4) who underwent conventional chemotherapy and consecutive allogeneic bone marrow transplantation (BMT). The median BM-MVD at diagnosis was 30/mm2 (range: 17-48/mm2) and thus was significantly higher compared to controls (n = 9; BM-MVD: median 7/mm2, range 2-11/mm2; P < 0.05). In patients who failed to achieve a complete remission (CR) in response to induction chemotherapy, the BM-MVD was significantly higher (median: 41.5/mm2) at diagnosis than in patients who entered CR (median: 28.5/mm2, P < 0.05). In addition, patients with high BM-MVD ( > 30 mm2) had a significantly shorter overall survival compared to patients with a lower BM-MVD ( < 30 mm2, P < 0.05). Moreover, patients with a high BM-MVD ( > 30 mm2) were found to have a significantly higher risk of relapse (P < 0.05). In 4 patients in whom a continuous complete remission was documented after BMT, the BM-MVD levels were analyzed at diagnosis as well as between day + 80 and day + 100 after BMT. In all 4 patients, the BM-MVD was found to decrease in response to BMT until day 100 (P < 0.05). Together, our data suggest that the BM-MVD could be a prognostic parameter concerning survival in patients with AML undergoing allogeneic BMT.