gebhart/patrepeval huggingface dataset:
MIHAIL KUZMIN: SZÁRNYAK Nevelődési regény vagy beavatási regény? Polémia az orosz irodalmi tradícióval (2016)

A &lt;em&gt;Szárnyak &lt;/em&gt;a maga idejében mint az első orosz homoerotikus regény vált híressé és egyben hírhedtté. A szovjet olvasóközönség azonban már nem ismerhette. Kuzmin a tiltott írók kategóriájába tartozott, s így regénye újbóli felfedezésére hazájában csak az 1990-es évek kezdetétől kerülhetett sor. Mihail Kuzmin kisregényét egyfelől nevelődési regénynek (Erziehungsroman), másfelől beavatási regénynek tekintem. Ezen a ponton is kapcsolódik Kuzmin műve egyrészt a XIX. századi orosz regény tradíciójához, másrészt, mint regény-iniciáció, beavatás-regény az orosz szimbo- lista regényekhez. Ez a kettős kapcsolódás végigvonul a próza-struktúra minden elemén, beleértve az utalás- és idézetrendszereket. Kuzmin regényében a beavatáshoz nem kapcsolódik a mitológiai és egyéb tradícióra visszavezethető rítus, a „beava- tás” folyamat, melyben hasonlóan fontos szerepet játszanak a személyeken kívül a műalkotások, operák, irodalom, s főképp a képzőművészet, hiszen rajtuk keresztül közvetítődik a beavatáshoz szükséges kulturális tartalom. Ványa, a kisregény fő alak- ja a műalkotások nyújtotta „kettős tükrözés” segítségével érti meg a „természetet”, s ily módon önnön természetét is, s fogadja el magát a homoerotikus kapcsolatot.
Periodic Excitation for Jet Vectoring and Enhanced Spreading (2001)

The effects of periodic excitation on the evolution of a turbulent jet were studied experimentally. A short, wide-angle diffuser was attached to the jet exit and excitation was introduced at the junction between the jet exit and the diffuser inlet. The introduction of high amplitude periodic excitation at the jet exit enhances the mixing and promotes attachment of the jet shear-layer to the diffuser wall. Vectoring is achieved by applying the excitation over a fraction of the circumference of the circular jet, enhancing its spreading rate on the excited side and its tendency to reattach to that side. Static deflection studies demonstrate that the presence of the wide-angle diffuser increases the effectiveness of the added periodic momentum due to a favorable interaction between the excitation, the jet shear-layer and the diffuser wall. This point was further demonstrated by the evolution of a wave packet that was excited in the jet shear-layer. Strong amplification of the wave packet was measured with a diffuser attached to the jet exit. The turbulent jet responds quickly (10-20 msec) to step changes in the level of the excitation input. The response scales with the jet exit velocity and is independent of the Reynolds number. Jet deflection angles were found to be highly sensitive to the relative direction between the excitation and the jet flow and less sensitive to the excitation frequency. The higher jet deflection angles were obtained for a diffuser length of about two diameters and for diffusers with half-angles greater than 15 degrees.
Production of arachidonic acid by filamentous fungus, Mortierella alliacea strain YN‐15 (2001)

Abstract A filamentous fungus producing significant levels of arachidonic acid (AA, C20∶4n−6) was isolated from a freshwater pond sample and assigned to the species Mortierella alliacea . This strain, YN‐15, accumulated AA mainly in the form of triglyceride in its mycelia. An optimized culture in 25 L of medium containing 12% glucose and 3% yeast extract yielded 46.1 g/L dry cell weight, 19.5 g/L total fatty acid, and 7.1 g/L AA by 7‐d cultivation in a 50‐L jar fermenter. Assimilation of soluble starch by YN‐15 was notably enhanced by the addition of oleic acid, soybean oil, ammonium sulfate, or potassium phosphate to a starch‐based medium. Using starch as a main carbon source in the pre‐pilot scale cultivation improved the production of AA by up to 5.0 g/L. Mortierella alliacea strain YN‐15 is therefore a promising fungal isolate for industrial production of AA and other polyunsaturated fatty acids.
Preservation of Mouse Sperm by Convective Drying and Storing in 3-O-Methyl-D-Glucose (2012)

With the fast advancement in the genetics and bio-medical fields, the vast number of valuable transgenic and rare genetic mouse models need to be preserved. Preservation of mouse sperm by convective drying and subsequent storing at above freezing temperatures could dramatically reduce the cost and facilitate shipping. Mouse sperm were convectively dried under nitrogen gas in the Na-EGTA solution containing 100 mmol/L 3-O-methyl-D-glucose and stored in LiCl sorption jars (Relative Humidity, RH, 12%) at 4°C and 22°C for up to one year. The functionality of these sperm samples after storage was tested by intracytoplasmic injection into mouse oocytes. The percentages of blastocysts produced from sperm stored at 4°C for 1, 2, 3, 6, and 12 months were 62.6%, 53.4%, 39.6%, 33.3%, and 30.4%, respectively, while those stored at 22°C for 1, 2, and 3 months were 28.8%, 26.6%, and 12.2%, respectively. Transfer of 38 two- to four-cell embryos from sperm stored at 4°C for 1 year produced two live pups while 59 two- to four-cell embryos from sperm stored at 22°C for 3 months also produced two live pups. Although all the pups looked healthy at 3 weeks of age, normality of offspring produced using convectively dried sperm needs further investigation. The percentages of blastocyst from sperm stored in the higher relative humidity conditions of NaBr and MgCl(2) jars and driest condition of P(2)O(5) jars at 4°C and 22°C were all lower. A simple method of mouse sperm preservation is demonstrated. Three-O-methyl-D-glucose, a metabolically inactive derivative of glucose, offers significant protection for dried mouse sperm at above freezing temperatures without the need for poration of cell membrane.
The metagenomic data life-cycle: standards and best practices (2017)

Metagenomics data analyses from independent studies can only be compared if the analysis workflows are described in a harmonized way. In this overview, we have mapped the landscape of data standards available for the description of essential steps in metagenomics: (i) material sampling, (ii) material sequencing, (iii) data analysis, and (iv) data archiving and publishing. Taking examples from marine research, we summarize essential variables used to describe material sampling processes and sequencing procedures in a metagenomics experiment. These aspects of metagenomics dataset generation have been to some extent addressed by the scientific community, but greater awareness and adoption is still needed. We emphasize the lack of standards relating to reporting how metagenomics datasets are analysed and how the metagenomics data analysis outputs should be archived and published. We propose best practice as a foundation for a community standard to enable reproducibility and better sharing of metagenomics datasets, leading ultimately to greater metagenomics data reuse and repurposing.
Representation and self-similarity of shapes (2003)

Representing shapes in a compact and informative form is a significant problem for vision systems that must recognize or classify objects. We describe a compact representation model for two-dimensional (2D) shapes by investigating their self-similarities and constructing their shape axis trees (SA-trees). Our approach can be formulated as a variational one (or, equivalently, as MAP estimation of a Markov random field). We start with a 2D shape, its boundary contour, and two different parameterizations for the contour (one parameterization is oriented counterclockwise and the other clockwise). To measure its self-similarity, the two parameterizations are matched to derive the best set of one-to-one point-to-point correspondences along the contour. The cost functional used in the matching may vary and is determined by the adopted self-similarity criteria, e.g., cocircularity, distance variation, parallelism, and region homogeneity. The loci of middle points of the pairing contour points yield the shape axis and they can be grouped into a unique free tree structure, the SA-tree. By implicitly encoding the (local and global) shape information into an SA-tree, a variety of vision tasks, e.g., shape recognition, comparison, and retrieval, can be performed in a more robust and efficient way via various tree-based algorithms. A dynamic programming algorithm gives the optimal solution in O(N/sup 1/), where N is the size of the contour.
Short Communication Differential Viral Protein Expression in Kaposi's Sarcoma-Associated Herpesvirus-Infected Diseases Kaposi's Sarcoma, Primary Effusion Lymphoma, and Multicentric Castleman's Disease (2000)

Kaposi’s sarcoma (KS)-associated herpesvirus (KSHV) is linked to KS, primary effusion lymphomas (PEL), and a subset of multicentric Castleman’s disease (MCD). Transcript mapping studies using PEL cell lines have allowed preliminary classification of viral gene expression into constitutive (class I) and inducible (class II/III) categories. To determine whether viral gene expression differs in vivo, we examined tissue sections of KSHV-infected disorders, using specific antibodies against proteins that are representative of the different expression classes of KSHV genes. ORF73/LANA appears to be a surrogate marker for KSHV infection because it is constitutively expressed in vitro and in vivo in all KSHV-infected cells. Expression of vIRF1, vIL6, and PF-8 proteins in the infected B cells of MCD lymph nodes reproduces the expression pattern observed in TPA-stimulated KSHV-infected B-cell lines. In contrast, the protein expression of the inducible viral genes that we tested in KS and PEL biopsies is restricted to PF-8 and vIL6, respectively. The tightly restricted expression of KSHV proteins in vivo differs from the dysregulated expression of inducible KSHV genes in vitro and suggests that viral gene expression in KSHV-infected cell lines does not accurately reflect what occurs in diseased tissues. These differences may be related to either cell-specific or immune restriction of viral replication. (Am J Pathol 2000, 156:743‐749)
Accelerated Training for CNN Distributed Deep Learning through Automatic\n Resource-Aware Layer Placement (2019)

The Convolutional Neural Network (CNN) model, often used for image\nclassification, requires significant training time to obtain high accuracy. To\nthis end, distributed training is performed with the parameter server (PS)\narchitecture using multiple servers. Unfortunately, scalability has been found\nto be poor in existing architectures. We find that the PS network is the\nbottleneck as it communicates a large number of gradients and parameters with\nthe many workers. This is because synchronization with the many workers has to\noccur at every step of training. Depending on the model, communication can be\nin the several hundred MBs per synchronization. In this paper, we propose a\nscheme to reduce network traffic through layer placement that considers the\nresources that each layer uses. Through analysis of the characteristics of CNN,\nwe find that placement of layers can be done in an effective manner. We then\nincorporate this observation within the TensorFlow framework such that layers\ncan be automatically placed for more efficient training. Our evaluation making\nuse of this placement scheme show that training time can be significantly\nreduced without loss of accuracy for many CNN models.\n
Structurally Ordered Fe3Pt Nanoparticles on Robust Nitride Support as a High Performance Catalyst for the Oxygen Reduction Reaction (2018)

Abstract The commercialization of fuel cell technologies requires a significant reduction in the amount of expensive platinum catalyst in the cathode while still maintaining high catalytic activity and stability. Herein a cost‐effective, highly durable, and efficient catalyst consisting of ordered Fe 3 Pt nanoparticles supported by mesoporous Ti 0.5 Cr 0.5 N (Fe 3 Pt/Ti 0.5 Cr 0.5 N) is demonstrated. The Fe 3 Pt/Ti 0.5 Cr 0.5 N catalyst exhibits a five‐fold increase in mass activity relative to a Pt/C catalyst at 0.9 V for the oxygen reduction reaction. More importantly, the catalyst shows a minimal loss of activity after 5000 potential cycles (9.7%). The enhanced activity of the ordered Fe 3 Pt/Ti 0.5 Cr 0.5 N catalyst, in combination with its enhanced stability, makes it very promising for the development of new cathode catalysts for fuel cells.
ChemInform Abstract: The Rational Design of Potential Chemotherapeutic Agents: Synthesis of Bryostatin Analogues (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
PDZ Domain-containing 1 (PDZK1) Protein Regulates Phospholipase C-β3 (PLC-β3)-specific Activation of Somatostatin by Forming a Ternary Complex with PLC-β3 and Somatostatin Receptors (2012)

Phospholipase C-β (PLC-β) is a key molecule in G protein-coupled receptor (GPCR)-mediated signaling. Many studies have shown that the four PLC-β subtypes have different physiological functions despite their similar structures. Because the PLC-β subtypes possess different PDZ-binding motifs, they have the potential to interact with different PDZ proteins. In this study, we identified PDZ domain-containing 1 (PDZK1) as a PDZ protein that specifically interacts with PLC-β3. To elucidate the functional roles of PDZK1, we next screened for potential interacting proteins of PDZK1 and identified the somatostatin receptors (SSTRs) as another protein that interacts with PDZK1. Through these interactions, PDZK1 assembles as a ternary complex with PLC-β3 and SSTRs. Interestingly, the expression of PDZK1 and PLC-β3, but not PLC-β1, markedly potentiated SST-induced PLC activation. However, disruption of the ternary complex inhibited SST-induced PLC activation, which suggests that PDZK1-mediated complex formation is required for the specific activation of PLC-β3 by SST. Consistent with this observation, the knockdown of PDZK1 or PLC-β3, but not that of PLC-β1, significantly inhibited SST-induced intracellular Ca(2+) mobilization, which further attenuated subsequent ERK1/2 phosphorylation. Taken together, our results strongly suggest that the formation of a complex between SSTRs, PDZK1, and PLC-β3 is essential for the specific activation of PLC-β3 and the subsequent physiologic responses by SST.
Carbon Nanotube Field Effect Transistors for High Speed Electronics (2006)

The frequency-independent performance of a carbon nanotube field effect transistor (CNT FET), at frequencies as high as 23 GHz, was demonstrated. The FET was fabricated using a top- gated geometry on a quartz substrate. The high frequency measurement was performed on this FET using a novel measurement approach, and for the first time we demonstrated the CNT FET continues to operate at frequencies up to 23 GHz without loss of gain. This observed maximum operating frequency represents a significant breakthrough in the realization of carbon nanotube-based electronics for low-power, high frequency applications.
A Tunable Optical Tapped-Delay-Line that Simultaneously and Independently Processes Multiple Input WDM Data Signals (2013)

We demonstrate an optical tapped-delay-line that is reconfigurable with complex tap-coefficients and independently and simultaneously performs data pattern recognition, equalization, and QAM format conversion on eight B/QPSK WDM signals at both 20 and 26 Gbaud, demonstrating &gt;400 Gbit/s processing speed.
In Vitro Multispectral Diffuse Reflectance Measurements of the Porcine Fundus (2005)

Variations in fundus spectral reflectance with change in the illumination angle were found to deviate from Lambertian behavior, varying from Lambertian by 5% across the spectrum in one sample and 20% in a second sample. Intravitreal illumination resulted in markedly decreased extraneous reflections.
ChemInform Abstract: Novel Stereoselective Route to cis‐Chrysanthemic Acid. (1989)

Abstract 2,2,5,5‐Dimethylcyclohexane‐1,3‐dione (I), prepared from dimedone and methyl iodide, reacts consecutively with potassium tert‐butoxide and bromine to form the bicyclo(3.1.0)hexanedione (II).
Evolution of the Modern Human Face: Aesthetic and Attributive Judgments of a Female Profile Warped Along a Continuum of Paedomorphic to Late Archaic Craniofacial Structure (1998)

(1998). Evolution of the Modern Human Face: Aesthetic and Attributive Judgments of a Female Profile Warped Along a Continuum of Paedomorphic to Late Archaic Craniofacial Structure. Ecological Psychology: Vol. 10, No. 1, pp. 1-24.
Tachykinin Receptors and Noncholinergic Bronchoconstriction in the Guinea-Pig Isolated Bronchi (1991)

The aim of the study was to assess which type(s) of tachykinin receptor mediate the noncholinergic bronchoconstriction produced by activation (electrical field stimulation) of capsaicin-sensitive primary afferents in epithellum-denuded guinea-pig isolated bronchi. Experiments with natural and synthetic tachykinin agonists indicated the presence of both NK-1 and NK-2 receptors at this level. Experiments with the putative NK-1 (L668, 169) or NK-2 (MEN 10,207, MEN 10,376, L659,877, and R396) selective antagonists against NK-1 and NK-2 selective agonists further supported this conclusion. All the tachykinin antagonists tested reduced the noncholinergic bronchoconstriction to field stimulation with the order of potency MEN 10,207 = MEN 10,376 greater than L659,877 greater than L668,169 congruent to R396. In the presence of peptidase inhibitors, the activity of MEN 10,376 toward the noncholinergic bronchoconstriction was slightly reduced, whereas that of L668,169 was increased. These findings demonstrate that both NK-1 and NK-2 receptors mediate the noncholinergic constriction produced by endogenous tachykinins in guinea-pig bronchi and that the relative contribution of NK-2 receptors is greater than that of NK-1. These findings implicate a major role for neurokinin A rather than for substance P as an endogenous bronchoconstrictor in the guinea-pig isolated bronchi. In the presence of peptidase inhibitors, the relative contribution of NK-1 receptors is increased.
Agent system development method based on agent patterns (1999)

As wide-area open networks such as the Internet and intranets grow larger, agent technology is attracting more attention.
Residue growth on metallic-hard mask after dielectric etching in fluorocarbon-based plasmas. I. Mechanisms (2010)

International audience
Synthesis and biological activity of a new semisynthetic cephalosporin, CN-92,982. (1980)

A new broad spectrum semisynthetic cephalosporin (CN-92,982) was prepared from the condensation of an acetylaminoacylaminophenyl pyridone with trans-7-[(D-2-phenylglycyl) amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-delta 3-cephem-4-carboxylic acid. The new cephalosporin displayed an in vitro antibacterial spectrum similar to other cephaloglycine types such as cefoperazone and SM-1652. The compound produced a high and prolonged blood level following a single intramuscular dose in a dog.
Mechanically flexible and expandable display with conductive-polymer-coated nylon fabric (2008)

We developed and characterized a mechanically flexible and expandable display with a conductive-polymer-coated nylon fabric which offers a new class of mechanical robustness on its pixels and electrodes. For mobile information displays such as electronic papers, the mechanical stability to expansion and the function to mechanically magnify the display area are very attractive. For this purpose, we utilized helical-coiled structure of nylon fabric as a substrate and selectively coated an organic conductive polymer of poly(3,4-ethylenedioxythiophene) (PEDOT):polystyrenesulfornate(PSS) on the fabric for constructing the pixels and electrodes of displays. Since the PEDOT:PSS-coated nylon is capable of mechanically expanding its electric wiring not by stretching the conductive film itself, but by changing pitch between coils, the fracture of the electronic materials is prevented under large deformation. The deformation of our structure reached the strain of 1.25 without large increase of the electric resistance. In our developed process of PEDOT:PSS patterning, KMPR photoresist was spontaneously penetrated into the defined area of nylon. The photoresist was lifted off after PEDOT:PSS was coated. Finally, the coloration of both the one pixel on a 4-pixel-display and the cactus shape was demonstrated with their areas expanded at the strain of 0.3.
Inhibition of the HER2-YB1-AR axis with Lapatinib synergistically enhances Enzalutamide anti-tumor efficacy in castration resistant prostate cancer (2015)

Incurable castration-resistant prostate cancer (CRPC) is driven by androgen receptor (AR) activation. Potent therapies that prevent AR signaling, such as Enzalutamide (ENZ), are mainstay treatments for CRPC; however patients eventually progress with ENZ resistant (ENZR) disease. In this study, we investigated one mechanism of ENZ resistance, and tried to improve therapeutic efficiency of ENZ. We found HER2 expression is increased in ENZR tumors and cell lines, and is induced by ENZ treatment of LNCaP cells. ENZ-induced HER2 overexpression was dependent on AKT-YB1 activation and modulated AR activity. HER2 dependent AR activation in LNCaP and ENZR cells was effectively blocked by treatment with the EGFR/HER2 inhibitor Lapatinib, which reduced cell viability and increased apoptosis. Despite efficacy in vitro, in vivo monotherapy with Lapatinib did not prevent ENZR tumor growth. However, combination treatment of Lapatinib with ENZ most effectively induced cell death in LNCaP cells in vitro and was more effective than ENZ alone in preventing tumor growth in an in vivo model of CRPC. These results suggest that while HER2 overexpression and subsequent AR activation is a targetable mechanism of resistance to ENZ, therapy using Lapatinib is only a rational therapeutic approach when used in combination with ENZ in CRPC.
Hoxa5 overexpression correlates with IGFBP1 upregulation and postnatal dwarfism: evidence for an interaction between Hoxa5 and Forkhead box transcription factors (2002)

Transgenic mice expressing the homeobox gene Hoxa5 under the control of Hoxb2 regulatory elements present a growth arrest during weeks two and three of postnatal development, resulting in proportionate dwarfism. These mice present a liver phenotype illustrated by a 12-fold increase in liver insulin-like growth factor binding protein 1 (IGFBP1) mRNA and a 50% decrease in liver insulin-like growth factor 1 (IGF1) mRNA correlated with a 50% decrease in circulating IGF1. We show that the Hoxa5 transgene is expressed in the liver of these mice, leading to an overexpression of total (endogenous plus transgene) Hoxa5 mRNA in this tissue. We have used several cell lines to investigate a possible physiological interaction of Hoxa5 with the main regulator of IGFBP1 promoter activity, the Forkhead box transcription factor FKHR. In HepG2 cells, Hoxa5 has little effect by itself but inhibits the FKHR-dependent activation of the IGFBP1 promoter. In HuF cells, Hoxa5 cooperates with FKHR to dramatically enhance IGFBP1 promoter activity. This context-dependent physiological interaction probably corresponds to the existence of a direct interaction between Hoxa5 and FKHR and FoxA2/HNF3beta, as demonstrated by pull-down experiments achieved either in vitro or after cellular co-expression. In conclusion, we propose that the impaired growth observed in this transgenic line relates to a liver phenotype best explained by a direct interaction between Hoxa5 and liver-specific Forkhead box transcription factors, in particular FKHR but also Foxa2/HNF3beta. Because Hoxa5 and homeogenes of the same paralog group are normally expressed in the liver, the present results raise the possibility that homeoproteins, in addition to their established role during early development, regulate systemic physiological functions.