gebhart/patrepeval huggingface dataset:
Highly Stable Polymerizable Vesicles in Anionic Surfactant/Ammonium Salt Mixtures in the Presence of Cross-linking Monomers for Convenient Preparation of Hollow Nanospheres (2006)

Spontaneous and stable vesicles are formed from vinylbenzyltrimethylammonium chloride (VBTAC) and sodium dodecyl sulfate (SDS) ranging in molar composition from 3:7 to 7:3 in the presence of 30 mol % divinylbenzene (DVB). Dynamic light scattering analysis and transmission electron microscope observations revealed that microparticles with diameters around 120 nm (30%) and 580 nm (70%) were formed. Trapping efficiency of the vesicles examined with D-(+)-glucose amounted to ca. 15%. These vesicles were capable of undergoing polymerization in the presence of water-soluble radical initiators such as 2,2'-azobis[2-(2-imidazolin-2-yl)propane] dihydrochloride to fix the vesicular structure. Retention of the vesicle size and bimodal size distribution characteristics during the polymerization indicated that intravesicular polymerization prevailed over the intervesicular process. SDS was stably retained in the cross-linked vesicle and was not removed from the vesicle by exhaustive dialysis or ultrafiltration, due to the electrostatic interaction within the cross-linked polymeric framework produced from VBTAC and DVB. The resulting hollow nanospheres are readily redispersed in water without the aid of additional surfactants.
The expression level of BAALC-associated microRNA miR-3151 is an independent prognostic factor in younger patients with cytogenetic intermediate-risk acute myeloid leukemia (2015)

Acute myeloid leukemia (AML) is a heterogeneous disease whose prognosis is mainly related to the biological risk conferred by cytogenetics and molecular profiling. In elderly patients (⩾60 years) with normal karyotype AML miR-3151 have been identified as a prognostic factor. However, miR-3151 prognostic value has not been examined in younger AML patients. In the present work, we have studied miR-3151 alone and in combination with BAALC, its host gene, in a cohort of 181 younger intermediate-risk AML (IR-AML) patients. Patients with higher expression of miR-3151 had shorter overall survival (P=0.0025), shorter leukemia-free survival (P=0.026) and higher cumulative incidence of relapse (P=0.082). Moreover, in the multivariate analysis miR-3151 emerged as independent prognostic marker in both the overall series and within the unfavorable molecular prognostic category. Interestingly, the combined determination of both miR-3151 and BAALC improved this prognostic stratification, with patients with low levels of both parameters showing a better outcome compared with those patients harboring increased levels of one or both markers (P=0.003). In addition, we studied the microRNA expression profile associated with miR-3151 identifying a six-microRNA signature. In conclusion, the analysis of miR-3151 and BAALC expression may well contribute to an improved prognostic stratification of younger patients with IR-AML.
Sparse Fisher's linear discriminant analysis (2011)

Fisher's linear discriminant analysis (LDA) is traditionally used in statistics and pattern recognition to linearlyproject high-dimensional observations from two or more classes onto a low-dimensional feature space before classification. The computational complexity of the linear feature extraction method increases linearly with dimensionality of the observation samples. For high-dimensional signals, high computational cost can render the method unsuitable for implementation in real time. In this paper, we propose sparse Fisher's linear discriminant analysis, which allows one to search for lowdimensional subspaces, spanned by sparse discriminant vectors, in the high-dimensional space of observation samples from two classes. The sparsity constraints on the space of potential discriminant feature vectors are enforced using the sparse matrix transform (SMT) framework, proposed recently for regularized covariance estimation. Classical Fisher's LDA is a special case of sparse Fisher's LDA when the sparsity constraints on the feature vectors in the estimation algorithm are fully relaxed. The number of non-zero components in a discriminant direction estimated using our proposed discriminant analysis technique is tunable; this feature can be used to control the compromise between computational complexity and accuracy of the eventual classification algorithm. The experimental results discussed in the manuscript demonstrate the effectiveness of the new method for low-complexity data-classification applications.
Characterization of Ti-15Mo beta titanium alloy [orthopedic implants] (2002)

Beta titanium alloys are capable of providing a lower modulus of elasticity, enhanced corrosion resistance, improved fabrication response, and acceptable biocompatibility when compared to established titanium alloys. Small diameter Ti-15Mo bar product was solution treated at 800/spl deg/C and rapidly quenched to produce a fine grained /spl beta/ microstructure at room temperature. Comparisons of microstructure, mechanical properties, corrosion, and biocompatibility were made to Ti Grade 4, Ti-6Al-7Nb, Ti-6Al-4V, and 316L stainless steel. ASTM grain size, inclusion content, and primary plus secondary phases were determined using optical microscopy. Smooth and notch tensile results were compiled and corrosion evaluation by anodic polarization was performed in nitrogen purged Ringer's solution at 37/spl deg/C. Biocompatibility testing included short term animal screening according to ASTM F 1408, cytotoxicity assays, and two year implantation in dogs. Molybdenum sensitization data were also documented. Overall results revealed a fine grain /spl beta/ microstructure, excellent corrosion resistance, tensile strength equivalent to Grade 4 Ti, lower tensile strength compared to the other alloys, but superior notch tensile properties of Ti-15Mo. Biocompatibility evaluations suggested a satisfactory level of localized biological response.
Direct Detection of Anchor Damping in MEMS Tuning Fork Resonators (2018)

This paper presents the use of our approach to comprehensive measurements of the quality factor ( <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Q</i> ) of 1-MHz microelectromechanical system (MEMS) tuning fork resonators. We examined the most important mechanisms that are believed to limit the quality factor in MEMS tuning fork resonators (i.e., gas damping, thermoelastic dissipation (TED), anchor damping, and Akhiezer damping), and we were able to quantitatively account for each mechanism and to eliminate several from consideration. We take advantage of the elimination of TED at ~120 K, where the linear coefficient of thermal expansion (CTE) becomes 0. These observations enabled the first direct examination of the strength of anchor damping in megahertz tuning fork resonators, allowing the study of the effect of anchor design and other factors. In this megahertz frequency range, the wavelength of elastic waves far exceeds the dimensions of the die, so commonly used models cannot make predictions of anchor damping. Our results show that elastic energy can escape from the resonator through the anchor(s) and still be retained within the die. We find that anchor damping in these megahertz resonators is impacted more by die attach structures at the boundaries of the die than by the resonator anchor designs within the die. [2018-0038].
Attributed Graph Force Learning (2022)

In numerous network analysis tasks, feature representation plays an imperative role. Due to the intrinsic nature of networks being discrete, enormous challenges are imposed on their effective usage. There has been a significant amount of attention on network feature learning in recent times that has the potential of mapping discrete features into a continuous feature space. The methods, however, lack preserving the structural information owing to the utilization of random negative sampling during the training phase. The ability to effectively join attribute information to embedding feature space is also compromised. To address the shortcomings identified, a novel attribute force-based graph (AGForce) learning model is proposed that keeps the structural information intact along with adaptively joining attribute information to the node's features. To demonstrate the effectiveness of the proposed framework, comprehensive experiments on benchmark datasets are performed. AGForce based on the spring-electrical model extends opportunities to simulate node interaction for graph learning.
Change detection in teletraffic models (2000)

We propose a likelihood-based ratio test to detect distributional changes in common teletraffic models. These include traditional models like the Markov modulated Poisson process and processes exhibiting long range dependency, in particular, Gaussian fractional ARIMA processes. A practical approach is also developed for the case where the parameter after the change is unknown. It is noticed that the algorithm is robust enough to detect slight perturbations of the parameter value after the change. A comprehensive set of numerical results including results for the mean detection delay is provided.
Demonstration of a Digital CMOS Driver Codesigned and Integrated With a Broadband Silicon Photonic Switch (2011)

A custom 90-nm bulk digital CMOS switch driver is codesigned and integrated with a silicon photonic switch. A photonic device model is created within the electronic design environment, facilitating driver optimization and performance evaluation prior to fabrication. The fabricated drivers implemented in two variations produce transition times as low as 50 ps and generate open eye diagrams using supply voltages ranging from 0.8 to 5 V. The driver is hybrid integrated with a broadband low-power silicon photonic 2 × 2 switch, based on a modified Mach-Zehnder interferometer. The switch has demonstrated operation over 100 nm of spectral bandwidth with less than -17-dB crosstalk, greater than 25 °C tolerance to temperature variations, and compatibility with 1-V driving signals. The integration demonstrates the interoperability of the switch and driver, which together achieve transition times below 4 ns and average power consumption of 2 mW. Finally, throughput bandwidth of 160 Gb/s is demonstrated for all switch configurations via eye diagrams and bit error rate curves.
THE FUNCTION OF sRNA AS AMINO ACID ADAPTOR IN THE SYNTHESIS OF HEMOGLOBIN (1963)

According to the adaptor hypothesis of Crick [1] and Hoagland [2], the position of a particular amino acid in a polypeptide chain is determined, not by direct interaction between amino acid and template, but through the mediation of an sRNA molecule that functions as an adaptor. The hypothesis was tested by Chapeville et al. [3] in a cell-free protein-synthesizing system from E. coli, using a synthetic polynucleotide as template. Cysteine attached to sRNA was converted to alanine, forming an Ala-sRNACYSH hybrid (Fig. 1). The alanine was transferable into polypeptide in response to poly UG, which ordinarily stimulates the incorporation of cysteine but not of alanine. The present investigation shows that the result indicated by the use of the artificial messenger poly UG applies as well to the synthesis of hemoglobin, thus confirming the validity of the adaptor hypothesis in the synthesis of natural protein.
Electrical characteristics of gated‐anode diodes based on normally‐off GaN HEMT structures for rectenna applications (2021)

Abstract Here, a gated‐anode diode (GAD) is proposed where an anode electrode is formed by connecting a gate electrode and an ohmic electrode of a normally‐off GaN HEMT for a 5.8 GHz rectenna. A wide recessed gate GaN GADs were prepared and the recess length dependence of their electrical characteristics was investigated. Typical DC characteristics of the HEMTs are a threshold voltage ( V th ) of +0.3 V and a maximum drain current ( I max ) of 300 mA/mm. The GADs showed the characteristics of maximum forward current ( I f ) of 350 mA/mm, reverse breakdown voltage ( BV r ) of 40 V, and off‐state capacitance ( C off ) of 0.28 pF/mm by using optimized recess length. We constructed SPICE model of the GADs. The SPICE simulation predicted a rectifier efficiency of 81% and a DC output power of 10 W for bridge type 5.8 GHz rectifier using four GADs with each gate width of 0.8 mm.
Diabetes and obesity trends in Fiji over 30 years (2015)

Prevalence of T2DM in Fiji is projected to continue increasing, driven by rising obesity, with consequences for premature mortality and life expectancy.
A mobile ad-hoc satellite and wireless Mesh networking approach for Public Safety communications (2008)

It is widely recognized that emergency management and disaster recovery systems are an issue of paramount importance in communities through the world. The definition of a Public Safety communications infrastructure is a high-priority task due to the lack of interoperability between emergency response departments, the reduced mobility during coordinated operations on a broad scale and the need for access to critical data in real-time. This work proposes an “ad-hoc networking” approach for emergency mobile communications in a satellite and wireless mesh scenario, in which ad hoc and IPv6 mobility mechanisms are combined together. First we analyze mobility management aspects and IP layer protocols and then we focus on Proxy Mobile IPv6, a network-based mobility management protocol which represents the more suitable micro-mobility solution for the proposed scenario with heterogeneous networks and unmodified mobile terminals.
Mannose Trimming Is Required for Delivery of a Glycoprotein from EDEM1 to XTP3-B and to Late Endoplasmic Reticulum-associated Degradation Steps (2010)

Although the trimming of α1,2-mannose residues from precursor N-linked oligosaccharides is an essential step in the delivery of misfolded glycoproteins to endoplasmic reticulum (ER)-associated degradation (ERAD), the exact role of this trimming is unclear. EDEM1 was initially suggested to bind N-glycans after mannose trimming, a role presently ascribed to the lectins OS9 and XTP3-B, because of their in vitro affinities for trimmed oligosaccharides. We have shown before that ER mannosidase I (ERManI) is required for the trimming and concentrates together with the ERAD substrate and ERAD machinery in the pericentriolar ER-derived quality control compartment (ERQC). Inhibition of mannose trimming prevents substrate accumulation in the ERQC. Here, we show that the mannosidase inhibitor kifunensine or ERManI knockdown do not affect binding of an ERAD substrate glycoprotein to EDEM1. In contrast, substrate association with XTP3-B and with the E3 ubiquitin ligases HRD1 and SCF(Fbs2) was inhibited. Consistently, whereas the ERAD substrate partially colocalized upon proteasomal inhibition with EDEM1, HRD1, and Fbs2 at the ERQC, colocalization was repressed by mannosidase inhibition in the case of the E3 ligases but not for EDEM1. Interestingly, association and colocalization of the substrate with Derlin-1 was independent of mannose trimming. The HRD1 adaptor protein SEL1L had been suggested to play a role in N-glycan-dependent substrate delivery to OS9 and XTP3-B. However, substrate association with XTP3-B was still dependent on mannose trimming upon SEL1L knockdown. Our results suggest that mannose trimming enables delivery of a substrate glycoprotein from EDEM1 to late ERAD steps through association with XTP3-B.
Lattice Quantization with Side Information: Codes, Asymptotics, and Applications in Sensor Networks (2006)

We consider the problem of rate/distortion with side information available only at the decoder. For the case of jointly-Gaussian source X and side information Y, and mean-squared error distortion, Wyner proved in 1976 that the rate/distortion function for this problem is identical to the conditional rate/distortion function R_{X|Y}, assuming the side information Y is available at the encoder. In this paper we construct a structured class of asymptotically optimal quantizers for this problem: under the assumption of high correlation between source X and side information Y, we show there exist quantizers within our class whose performance comes arbitrarily close to Wyner's bound. As an application illustrating the relevance of the high-correlation asymptotics, we also explore the use of these quantizers in the context of a problem of data compression for sensor networks, in a setup involving a large number of devices collecting highly correlated measurements within a confined area. An important feature of our formulation is that, although the per-node throughput of the network tends to zero as network size increases, so does the amount of information generated by each transmitter. This is a situation likely to be encountered often in practice, which allows us to cast under new--and more ``optimistic''--light some negative results on the transport capacity of large-scale wireless networks.
Cooperative checkpointing for supercomputing systems (2005)

A system-level checkpointing mechanism, with global knowledge of the state and health of the machine, can improve performance and reliability by dynamically deciding when to skip checkpoint requests made by applications. This thesis presents such a technique, called cooperative checkpointing, and models its behavior as an online algorithm. Where C is the checkpoint overhead and I is the request interval, a worst-case analysis proves a lower bound of (2 + ⌊ C ⌋)-competitiveness for deter-I ministic cooperative checkpointing algorithms, and proves that a number of simple algorithms meet this bound. Using an expected-case analysis, this thesis proves that an optimal periodic checkpointing algorithm that assumes an exponential failure distribution may be arbitrarily bad relative to an optimal cooperative checkpointing algorithm that permits a general failure distribution. Calculations suggest that, under realistic conditions, an application using cooperative checkpointing may make
Interleukin-12–Activated Natural Killer Cells Recognize B7 Costimulatory Molecules on Tumor Cells and Autologous Dendritic Cells (1998)

Activation of natural killer (NK) cells in the presence of interleukin-12 (IL-12) augments the capacity of these effector cells to recognize B7-1– and B7-2–expressing target cells. These effector cells also efficiently lyse autologous B7-positive progenitor or organ-derived dendritic cells, suggesting a physiologic regulatory pathway between IL-12, NK cells, and B7-expressing antigen-presenting cells. Although IL-12–activated NK cells secreted higher levels of interferon-γ, this cytokine did not play a role in synergistic effects of IL-12 and B7 on NK activation. The B7-counterreceptor was found to be selectively upregulated on IL-2/IL-12 as compared with IL-2–activated NK cells. CD28 is functionally involved in the recognition of B7 on target cells since IL-2/IL-12–activated NK cells derived from CD28 knockout mice were strongly reduced in their capacity to lyse syngeneic B7-positive tumor cells as well as antigen-presenting cells. However, recognition of B7 on allogeneic targets did not require the expression of CD28 on the IL-2/IL-12–activated NK cells. Hence, IL-12 triggers the expression of both CD28-dependent and CD28-independent mechanisms that allow NK cells to eliminate B7-positive target cells including autologous dendritic cells.
Privacy-Enhancing Queries in Personalized Search with Untrusted Service Providers (2012)

For personalized search, a user must provide her personal information. However, this sometimes includes the user's sensitive information about individuals such as health condition and private lifestyle. It is not sufficient just to protect the communication channel between user and service provider. Unfortunately, the collected personal data can potentially be misused for the service providers' commercial advantage (e.g. for advertising methods to target potential consumers). Our aim here is to protect user privacy by filtering out the sensitive information exposed from a user's query input at the system level. We propose a framework by introducing the concept of query generalizer. Query generalizer is a middleware that takes a query for personalized search, modifies the query to hide user's sensitive personal information adaptively depending on the user's privacy policy, and then forwards the modified query to the service provider. Our experimental results show that the best-performing query generalization method is capable of achieving a low traffic overhead within a reasonable range of user privacy. The increased traffic overhead varied from 1.0 to 3.3 times compared to the original query.
ChemInform Abstract: Stereoselective Addition of Grignard Reagents to Alkenes (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Plasmacytoid dendritic cells infiltrating ovarian cancer are associated with poor prognosis (2012)

Using two different and complementary approaches (flow cytometry and immunohistochemistry) on two independent cohorts of ovarian cancer patients, we found that accumulation of plasmacytoid dendritic cells (pDC) in tumors is associated with early relapse. This deleterious effect of tumor-associated pDC was evident when they are present in cancer epithelium but not in lymphoid aggregates.
Advanced Case Management Enabled by Business Provenance (2012)

Most human centric business activities, like the handling of an insurance claim or the design of an IT solution, do not follow a formal process model word-by-word. While there are often underlying processes in place, the real business operation typically encompasses a wider scope of actions. It includes unstructured segments of human activities, additional documents and interactions, the integration of remote systems and services, and the reactions to exceptional situations. With the case management approach, the knowledge worker in the center takes control and acts as an orchestrator of available services rather than being a part of an assembly line. This paper presents how data-centric web services can be used to build a service-oriented case management application, and how advanced analytics can leverage historical information to improve the effectiveness of business processes execution.
Author Correction: Phosphorylation Dynamics Dominate the Regulated Proteome during Early Xenopus Development (2018)

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.