gebhart/patrepeval huggingface dataset:
Arterial Injury Alters Metabolism Of The Arterial Wall (1981)

Results of our previous experiments indicate that following de-endothelialization aortic intima was thicker and contained more lipid in re-endothelialized (RA) and not de-en- dothelialized areas (DA) as we anticipated. Chemical analysis revealed that, in rabbits fed lipid-poor diets, there was 2 to 3 times as much cholesteryl ester (CE) in RA as compared to DA or uninjured aortas. In hypercholesterole- mic rabbits, aortic total cholesterol content correlated with serum cholesterol concentration in RA but not DA. Taken together, these findings suggest that aortic cholesterol (CH) and CE accumulation are not simply a result of increased filtration of lipoproteins into the de-endo- thelialized aorta but may result from altered metabolism of the arterial wall. Previous findings showing increased glycosaminoglycan (GAG) accumulation in RA supported this concept of altered metabolism and suggest that these GAGs may sequester lipoproteins. Recent experiments indicate that: 1) CE synthetic and hydrolytic activity as well as activities of several marker enzymes were increased in injured aortas, 2) CE hydrolytic activity was relatively greater in DA as compared to RA, 3) Neointimal smooth muscle cells (SMC) in DA synthesized increased quantities of PGI2 and that PGI2 increased CE hydrolase activity of SMC and 4) RA accumulate more 125I-apo-B-lipoproteins than adjacent DA. In conclusion, results indicate that RA accumulate more CE rich apo-B-lipoproteins and have decreased ability to degrade CE. This may, at least in part, account for the increased CH and CE accumulation in RA. Further, the findings suggest that arterial injury alters arterial wall metabolism and that interactions between neointimal smooth muscle cells and endothelial cells may modify these metabolic changes.
Generation of Arctic-like Rabies Viruses Containing Chimeric Glycoproteins Enables Serological Potency Studies (2017)

ABSTRACT Rabies viruses have the highest case fatality rate of any known virus and are responsible for an estimated 60,000 deaths each year. This is despite the fact that there are highly efficacious vaccines and postexposure prophylaxis available. However, while it is assumed these biologics provide protection against all rabies virus isolates, there are certain subdivisions of RABV lineages, such as within the Arctic-like RABV (AL rabies virus lineage, where data is limited and thus the potency of existing biologics has not been thoroughly assessed. By fusing the Arctic-like rabies virus envelope glycoprotein ecto- and transmembrane domains with the vesicular stomatitis virus cytoplasmic domain, a high titre (7.7 x 10 5 − 6.1 x 10 6 RLU/ml) pseudotyped virus was generated that was subsequently used in a pseudotyped virus neutralisation assay. These results showed that Arctic-like rabies viruses are neutralised to human, canine and feline vaccines and human post-exposure prophylaxis and this was not influenced by the swapping of the cytoplasmic domains (CVS-11 vs CVS-11etmVSVc; r = 0.99, p &lt; 0.0001). This study supports the concept that rabies virus vaccines and newly identified mAbs are able to neutralise rabies virus variants that cluster in a monophyletic clade, referred to as phylogroup I lyssaviruses.
Laser enhancement of thermophoretic deposition processes (1986)

Axial CO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> laser radiation has been shown to have a significant influence in modifying the deposition of silicon dioxide in the modified chemical vapor deposition (MCVD) fiber preform process. Experiments on soot deposition with a stationary burner have shown a doubling of both the rate of deposition and the deposition efficiency.
Three open PhD positions within the Research Group of Computer Architecture (UART) within a project on modeling and optimization for the next generation computer systems. (2013)

A generalized explanation is provided for the existence of the red- and blue-shifting nature of X-Z bonds (Z=H, halogens, chalcogens, pnicogens, etc.) in X-Z∙∙∙Y complexes based on computational studies on a selected set of weakly bonded complexes and analysis of existing literature data. The additional electrons and orbitals available on Z in comparison to H make for dramatic differences between the H-bond and the rest of the Z-bonds. The nature of the X-group and its influence on the X-Z bond length in the parent X-Z molecule largely controls the change in the X-Z bond length on X-Z∙∙∙Y bond formation; the Y-group usually influences only the magnitude of the effects controlled by X. The major factors which control the X-Z bond length change are: (a) negative hyperconjugative donation of electron density from X-group to X-Z σ* antibonding molecular orbital (ABMO) in the parent X-Z, (b) induced negative hyperconjugation from the lone pair of electrons on Z to the antibonding orbitals of the X-group, and (c) charge transfer (CT) from the Y-group to the X-Z σ* orbital. The exchange repulsion from the Y-group that shifts partial electron density at the X-Z σ* ABMO back to X leads to blue-shifting and the CT from the Y-group to the σ* ABMO of X-Z leads to red-shifting. The balance between these two opposing forces decides red-, zero- or blue-shifting. A continuum of behaviour of X-Z bond length variation is inevitable in X-Z∙∙∙Y complexes.
Best test pattern failure analysis flow for functional logic failure localization by IR-OBIRCH technique (2009)

The optical IR-OBIRCh technique is a standard failure analysis tool used to localize defects that are located at interconnects layers levels. For a functional logic failure, a failing test pattern is used to condition the device into a particular logic state to generate the failure. Commonly, the defect is detected for a set of test patterns. All test patterns will not provide the same IR-OBIRCh response. A random selection of test patterns may not lead to localize the defect by IR-OBIRCh technique or give fake results. We have performed an extended study of IR-OBIRCh response of a functional logic failure in function of test patterns. Based on these results a best test pattern failure analysis flow has been developed and implemented in order to localize a functional logic failure with IR-OBIRCh technique.
High speed microfluidic doublet flow in open pools driven by non-contact micromachined thermal sources (2005)

We report a phenomenon in which a micromachined heat source placed less than 50 /spl mu/m above the surface of a liquid drives a high-speed doublet flow pattern with linear velocities reaching nearly 5 mm/sec and rotational velocities up to 1200 rpm. Tests were performed on a 50-100 /spl mu/m-thick layer of water containing 3 /spl mu/m polystyrene beads for flow visualization. The thermal source is a polyimide cantilever with an integrated heater near the tip, operated with input powers ranging from 0-32 mW. It has no moving parts and does not contact the liquid. The speed of the doublet flow scales with input power as well as liquid temperature, and is inversely related to the air gap between the heater and liquid surface. The orientation of the doublet flow can be reversed by changing the angle of the cantilever. A one-dimensional array of probes used in the same manner generates a linear flow pattern.
Catalytic Wet Gasification of Municipal and Animal Wastes (2007)

Currently there is worldwide interest in deriving energy from bio-based materials via gasification. Our objective was to assess the feasibility of wet gasification for treatment/energy conversion of both animal and municipal wastes. Wet wastes such as swine manure and raw sewage sludge could be processed directly via current wet gasification technology. Furthermore, these wastes generated high amounts of net energy based on reaction material and energy balances. Without use of an efficient heat recovery system, municipal solid wastes and unpaved feedlot manure would not generate positive energy return from wet gasification. Due to high sulfur content of the wastes, pretreatment to prevent the poisoning of catalysts is essential. The costs of a conceptual first generation wet gasification manure management system for a model swine farm were significantly higher than that of the anaerobic lagoon system. However, there are many significant environmental advantages of the wet gasification, e.g., BOD removal, odor elimination, and pathogen kill.
Linkage mapping of highly informative DNA polymorphisms within the human interferon-α receptor gene on chromosome 21 (1991)

Two polymorphic loci within the interferon-alpha receptor (IFNAR) gene on human chromosome 21 have been identified and mapped by linkage analysis in 40 CEPH families. These markers are (1) a multiallelic RFLP with an observed heterozygosity of 0.72 and (2) a variable (AT3)n short sequence repeat at the poly(A) tail of an Alu sequence (AluVpA) with an observed heterozygosity of 0.83. This locus is close to D21S58 (theta = 0.02, zeta = 36.76) and D21S17 (theta = 0.02, Zeta = 21.76) with chromosomal band 21q22.1. Multipoint linkage analysis suggests the most likely locus order to be 21cen-D21S58-IFNAR-D21S17-21qter. Given its high heterozygosity, the IFNAR gene can be used as an index marker on human chromosome 21.
HRVCam: robust camera-based measurement of heart rate variability (2021)

HRVCam can be used on top of iPPG estimation algorithms to provide robust HRV measurements making camera-based HRV practical.
Ligands Affect Hydrogen Absorption and Desorption by Palladium Nanoparticles (2019)

We report herein in situ X-ray diffraction experiments that show that surface ligands affect the rates of hydrogen absorption and desorption in octahedral palladium nanoparticles. This observation was made possible by: (i) using a UV-driven photolysis and ozonolysis treatment to convert the ligand-stabilized palladium nanoparticles to pristine (i.e., ligand-free) nanoparticles while maintaining the size and shape of the core; and (ii) tracking in situ the phase transformation under a hydrogen environment. Our experiments revealed that pristine nanoparticles absorb and desorb hydrogen 10-fold faster than the corresponding ligated samples. This finding is supported by comparing octahedral nanoparticles stabilized by two different types of ligand coatings that both show faster hydrogen absorption and desorption after ligand removal. The data indicate that in addition to nanoparticle shape, surface structuring, and size, the ligand shell must be taken into account when examining hydrogen absorption and desorption in palladium nanoparticles.
Calculating Grounding-Electrode Impedance Using Fall-of-Potential and Impedance Methods (2010)

This example provides a real-world application (which could be measured in practice) for students in a numerical analysis class studying the finite-difference methods. The Impedance Method is very similar to the classical finite-difference method. In this paper, it is used to model single- and double-grounding electrode systems for residential construction in various types of soil. These models are used to conduct a numerical electrode-potential test, and to calculate the Earth impedance of simple or dual-grounding electrode systems in two dimensions to determine the theoretical efficacy of the grounding system. Depending on the type of soil and the distance between the grounding electrodes, the second electrode mayor may not sufficiently ground the system. Since many of our students have some experience with residential or agricultural electrical systems, this application provides motivation and interest. It also provides an opportunity to introduce the National Electrical Code in an electrical-engineering context.
Au-mediated low-temperature solid phase epitaxial growth of a SixGe1−x alloy on Si(001) (1996)

The evolution of microstructure during Au-mediated solid phase epitaxial growth of a SixGe1−x alloy film on Si(001) was investigated by in situ sheet resistance measurements, x-ray diffraction, conventional and high-resolution transmission electron microscopy, energy dispersive x-ray spectroscopy, and Rutherford backscattering spectrometry. Annealing amorphous-Ge/Au bilayers on Si(001) to temperatures below 120 °C caused changes primarily in the microstructure of the Au film. Near ≊130 °C, Ge from the top layer diffused and crystallized along the grain boundaries of Au. The Ge that had reached the Au/Si (001) interface mixed with Si from the substrate, to form epitaxial SixGe1−x islands on Si (001). Si from the substrate had dissolved into Au before entering the growing epitaxial islands. Meanwhile, the Au that was displaced by Ge that filled the Au grain boundaries, diffused into the top layer along columnar voids in the amorphous Ge film. With increasing temperature, more Au was displaced to the top by the flux of Ge towards the substrate, facilitating further epitaxial growth and the coalescence of epitaxial SixGe1−x islands. At 310 °C, the initial Au film was displaced completely to the top by a laterally continuous SixGe1−x epilayer of uniform composition (x≊0.15). The epilayer thickness was limited by that of the initial Au film. Twins and residual amounts of Au trapped near the SixGe1−x/Si(001) interface were the predominant defects observed in the completely strain-relaxed SixGe1−x epilayer.
274: Long-Term Affects of Lleal Conduit Urinary Diversion on Upper Urinary Tract in Bladder Cancer (2005)

You have accessJournal of UrologyModerated Poster, Sunday, May 22, 2005 8:00 - 10:00 am1 Apr 2005274: Long-Term Affects of Lleal Conduit Urinary Diversion on Upper Urinary Tract in Bladder Cancer Won Jae Yang, Sung Joon Hong, Seung Choul Yang, Byung Ha Chung, Koon Ho Rha, Young Deuk Choi, and Jin Moo Lee Won Jae YangWon Jae Yang More articles by this author , Sung Joon HongSung Joon Hong More articles by this author , Seung Choul YangSeung Choul Yang More articles by this author , Byung Ha ChungByung Ha Chung More articles by this author , Koon Ho RhaKoon Ho Rha More articles by this author , Young Deuk ChoiYoung Deuk Choi More articles by this author , and Jin Moo LeeJin Moo Lee More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)34539-7AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "274: Long-Term Affects of Lleal Conduit Urinary Diversion on Upper Urinary Tract in Bladder Cancer." The Journal of Urology, 173(4S), pp. 75–76 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 173Issue 4SApril 2005Page: 75-76 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Won Jae Yang More articles by this author Sung Joon Hong More articles by this author Seung Choul Yang More articles by this author Byung Ha Chung More articles by this author Koon Ho Rha More articles by this author Young Deuk Choi More articles by this author Jin Moo Lee More articles by this author Expand All Advertisement PDF DownloadLoading ...
Resveratrol preserves the function of human platelets stored for transfusion (2015)

Stored platelets undergo biochemical, structural and functional changes that lead to decreased efficacy and safety of platelet transfusions. Not only do platelets acquire markers of activation during storage, but they also fail to respond normally to agonists post-storage. We hypothesized that resveratrol, a cardioprotective antioxidant, could act as a novel platelet storage additive to safely prevent unwanted platelet activation during storage, while simultaneously preserving normal haemostatic function. Human platelets treated with resveratrol and stored for 5 d released less thromboxane B2 and prostaglandin E2 compared to control platelets. Resveratrol preserved the ability of platelets to aggregate, spread and respond to thrombin, suggesting an improved ability to activate post-storage. Utilizing an in vitro model of transfusion and thromboelastography, clot strength was improved with resveratrol treatment compared to conventionally stored platelets. The mechanism of resveratrol's beneficial actions on stored platelets was partly mediated through decreased platelet apoptosis in storage, resulting in a longer half-life following transfusion. Lastly, an in vivo mouse model of transfusion demonstrated that stored platelets are prothrombotic and that resveratrol delayed vessel occlusion time to a level similar to transfusion with fresh platelets. We show resveratrol has a dual ability to reduce unwanted platelet activation during storage, while preserving critical haemostatic function.
Two differentially stable rDNA loci coexist on the same chromosome and form a single nucleolus (2023)

The nucleolus is the most prominent membraneless compartment within the nucleus-dedicated to the metabolism of ribosomal RNA. Nucleoli are composed of hundreds of ribosomal DNA (rDNA) repeated genes that form large chromosomal clusters, whose high recombination rates can cause nucleolar dysfunction and promote genome instability. Intriguingly, the evolving architecture of eukaryotic genomes appears to have favored two strategic rDNA locations-where a single locus per chromosome is situated either near the centromere (<i>CEN</i>) or the telomere. Here, we deployed an innovative genome engineering approach to cut and paste to an ectopic chromosomal location-the ~1.5 mega-base rDNA locus in a single step using CRISPR technology. This "megablock" rDNA engineering was performed in a fused-karyotype strain of <i>Saccharomyces cerevisiae</i>. The strategic repositioning of this locus within the megachromosome allowed experimentally mimicking and monitoring the outcome of an rDNA migratory event, in which twin rDNA loci coexist on the same chromosomal arm. We showed that the twin-rDNA yeast readily adapts, exhibiting wild-type growth and maintaining rRNA homeostasis, and that the twin loci form a single nucleolus throughout the cell cycle. Unexpectedly, the size of each rDNA array appears to depend on its position relative to the <i>CEN</i>, in that the locus that is <i>CEN</i>-distal undergoes size reduction at a higher frequency compared to the <i>CEN</i>-proximal counterpart. Finally, we provided molecular evidence supporting a mechanism called paralogous <i>cis</i>-rDNA interference, which potentially explains why placing two identical repeated arrays on the same chromosome may negatively affect their function and structural stability.
9-Cyano-10-methoxycarbonylanthracene as a Visible Organic Photoredox Catalyst in the Two-Molecule Photoredox System (2022)

Visible-light-induced decarboxylative and deboronative reactions using two-molecule organic photoredox catalysts, namely, phenanthrene (Phen) and biphenyl (BP), as electron donors and 9-cyano-10-methoxycarbonylanthracene <b>1a</b> as an electron acceptor were achieved. The high solubility of <b>1a</b> significantly improved the reaction efficiency and product yield. In addition, the facile tuning of the oxidation potential of the electron-donor molecule via the replacement of Phen with BP enabled the application of the two-molecule photoredox system to a wide range of substrates.
Investigation of Acceleration Performance Feeling on a Rotary Engine Sports Car with Driving Simulator (2003)

&lt;div class="htmlview paragraph"&gt;Subjective evaluation tests of “Acceleration Performance Feeling” with a driving simulator have been carried out on a rotary engine sports car. Additionally, although the test condition is limited, a test on an in-line four-cylinder engine sedan has been carried out. Influencing factors were analyzed through the experimental design and the influences of acceleration, gas pedal controllability, engine sound and their interactions were quantified. As the result, it has been found that the interactions must be considered in addition to main effect of each factor to improve users' evaluation especially on a rotary engine sports car. Furthermore, it is concluded that influencing factors are different between a rotary engine sports car and an in-line four-cylinder engine sedan.&lt;/div&gt;
POLYMERIZED LIPOSOME AS THE CARRIER OF HEME. A PHYSICALLY STABLE OXYGEN CARRIER UNDER PHYSIOLOGICAL CONDITIONS (1985)

Abstract By incorporating the lipid-heme in the polymerized liposome, conc. and mechanically stable heme solution ([heme] = 10 mM) was prepared; this solution (100 ml) could bind molecular oxygen (ca. 23 ml) reversibly under physiological conditions even in a high speed flowing system.
Free radicals as clathrate hosts: crystal and molecular structure of 1: 1 perchlorotriphenylmethyl radical–benzene (1987)

The perchlorotriphenylmethyl radical (2) acts as a clathrate host for benzene, halogenobenzenes, and 1,4-dioxane giving inclusion compounds with different stabilities; the structure of (2)·C6H6, established by X-ray diffraction, shows the guest molecules located in channels between the hosts.
Flammability and mechanical properties of biochars made in different pyrolysis reactors (2021)

The effect of pyrolysis reactors on the properties of biochars (with a focus on flammability and mechanical characteristics) were investigated by keeping factors such as feedstock, carbonisation temperature, heating rate and residence time constant. The reactors employed were hydrothermal, fixed-bed batch vertical and fixed-bed batch horizontal-tube reactors. The vertical and tube reactors, at the same temperature, produced biochars having comparable elemental carbon content, surface functionalities, thermal degradation pattern and peak heat release rates. The hydrothermal reactor, although, a low-temperature process, produced biochar with high fire resistance because the formed tarry volatiles sealed water inside the pores, which hindered combustion. However, the biochar from hydrothermal reactor had the lowest nanoindentation properties whereas the tube reactor-produced biochar at 300 °C had the highest nanoindentation-hardness (290 Megapascal) and modulus (ca. 4 Gigapascal) amongst the other tested samples. Based on the inherent flammability and mechanical properties of biochars, polymeric composites’ properties can be predicted that can include them as constituents.
Matrix approach of Full-Field OCT for volumetric imaging of an opaque human cornea (2019)

We report on a matrix approach of optical imaging that allows to overcome aberration and multiple scattering issues in microscopy. This allows in-depth diffraction-limited imaging of biological media over a wide field-of-view (FOV).