gebhart/patrepeval huggingface dataset:
Energy level alignments at tris(8-hydroquinoline) aluminum/8-hydroquinolatolithium/aluminum interfaces (2008)

The electronic structures of tris(8-hydroquinoline) aluminum (Alq3)∕8-hydroquinolatolithium (Liq)/Al interfaces were studied using in situ ultraviolet and x-ray photoelectron spectroscopy. We constructed complete energy level diagrams and analyzed chemical interactions at the interface. When Liq was inserted between Al and Alq3, the electron injection barrier was reduced by 0.56eV compared to the structure without Liq. Additionally, a gap state was observed in the gap of Liq, which is related to an interfacial reaction. The N 1s spectra revealed that there were destructive chemical reactions between Alq3 and Al, which could be prevented by inserting Liq between them.
Battery Materials Exploration with Neutrons and Synchrotron X-Rays (2016)

The increasing demands for alternative energy sources and energy storage systems have created a fast growing global market for rechargeable batteries. Extensive research activities are in progress worldwide aiming to develop reliable, cheap, environmentally benign and high-performance materials for advanced rechargeable batteries. Fundamental materials exploration is critical to achieve the next generation battery technology. X-rays and neutrons interact with matter in different ways, thus are frequently used as complementary tools for studying materials at the electronic, atomic and molecular levels. We have been utilizing synchrotron x-ray and neutron techniques to investigate a large variety of materials for energy applications. In this poster, we will present our recent results on both in-situ and ex-situ studies of battery materials using various neutrons and synchrotron x-ray techniques, including diffraction, imaging and spectroscopy. We will also discuss the challenges in battery materials research, and our future experimental approaches and computational modeling. ( Use of the Advanced Photon Source was supported by the U.S. DOE Office of Science under Contract No. DE-AC02-06CH11357.)
Intracellular expression of IRF9 Stat fusion protein overcomes the defective Jak-Stat signaling and inhibits HCV RNA replication (2010)

Interferon alpha (IFN-α) binds to a cell surface receptor that activates the Jak-Stat signaling pathway. A critical component of this pathway is the translocation of interferon stimulated gene factor 3 (a complex of three proteins Stat1, Stat2 and IRF9) to the nucleus to activate antiviral genes. A stable sub-genomic replicon cell line resistant to IFN-α was developed in which the nuclear translocation of Stat1 and Stat2 proteins was prevented due to the lack of phosphorylation; whereas the nuclear translocation of IRF9 protein was not affected. In this study, we sought to overcome defective Jak-Stat signaling and to induce an antiviral state in the IFN-α resistant replicon cell line by developing a chimera IRF9 protein fused with the trans activating domain (TAD) of either a Stat1 (IRF9-S1C) or Stat2 (IRF9-S2C) protein. We show here that intracellular expression of fusion proteins using the plasmid constructs of either IRF9-S1C or IRF9-S2C, in the IFN-α resistant cells, resulted in an increase in Interferon Stimulated Response Element (ISRE) luciferase promoter activity and significantly induced HLA-1 surface expression. Moreover, we show that transient transfection of IRF9-S1C or IRF9-S2C plasmid constructs into IFN-α resistant replicon cells containing sub-genomic HCV1b and HCV2a viruses resulted in an inhibition of viral replication and viral protein expression independent of IFN-α treatment. The results of this study indicate that the recombinant fusion proteins of IRF9-S1C, IRF9-S2C alone, or in combination, have potent antiviral properties against the HCV in an IFN-α resistant cell line with a defective Jak-Stat signaling.
ChemInform Abstract: p‐Tolylsulfonylmethyl Isocyanide (TosMIC) — A Versatile Formaldehyde Equivalent with Reversed Polarity (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Programming by Examples - and its applications in Data Wrangling. (2016)

Programming by Examples (PBE) has the potential to revolutionize end-user programming by enabling end users, most of whom are non-programmers, to create scripts for automating repetitive tasks. PBE involves synthesizing intended programs in an underlying domain-specific language (DSL) from example based specifications (Ispec). We formalize the notion of Ispec and discuss some principles behind designing useful DSLs for synthesis. A key technical challenge in PBE is to search for programs that are consistent with the Ispec provided by the user. We present a divide-and-conquer based search paradigm that leverages deductive rules and version space algebras for manipulating sets of programs. Another technical challenge in PBE is to resolve the ambiguity that is inherent in the Ispec. We show how machine learning based ranking techniques can be used to predict an intended program within a set of programs that are consistent with the Ispec. We also present some user interaction models including program navigation and active-learning based conversational clarification that communicate actionable information to the user to help resolve ambiguity in the Ispec. The above-mentioned concepts are illustrated using practical PBE systems for data wrangling (including FlashFill, FlashExtract, FlashRelate), several of which have already been deployed in the real world.
Oxidation of 2-propanol to acetone by dioxygen on a platinized electrode under open-circuit conditions (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxidation of 2-propanol to acetone by dioxygen on a platinized electrode under open-circuit conditionsRobert DiCosimo and George M. WhitesidesCite this: J. Phys. Chem. 1989, 93, 2, 768–775Publication Date (Print):January 1, 1989Publication History Published online1 May 2002Published inissue 1 January 1989https://pubs.acs.org/doi/10.1021/j100339a051https://doi.org/10.1021/j100339a051research-articleACS PublicationsRequest reuse permissionsArticle Views685Altmetric-Citations44LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
MKK7 deficiency in mature neurons impairs parental behavior in mice (2020)

c-Jun N-terminal kinases (JNKs) are constitutively activated in mammalian brains and are indispensable for their development and neural functions. MKK7 is an upstream activator of all JNKs. However, whether the common JNK signaling pathway regulates the brain's control of social behavior remains unclear. Here, we show that female mice in which Mkk7 is deleted specifically in mature neurons (Mkk7<sup>flox/flox</sup> Syn-Cre mice) give birth to a normal number of pups but fail to raise them due to a defect in pup retrieval. To explore the mechanism underlying this abnormality, we performed comprehensive behavioral tests. Mkk7<sup>flox/flox</sup> Syn-Cre mice showed normal locomotor functions and cognitive ability but exhibited depression-like behavior. cDNA microarray analysis of mutant brain revealed an altered gene expression pattern. Quantitative RT-PCR analysis demonstrated that mRNA expression levels of genes related to neural signaling pathways and a calcium channel were significantly different from controls. In addition, loss of neural MKK7 had unexpected regulatory effects on gene expression patterns in oligodendrocytes. These findings indicate that MKK7 has an important role in regulating the gene expression patterns responsible for promoting normal social behavior and staving off depression.
Single -Addre s s - Spac e Operating Systems. (1996)

Trends toward shared-memory program- ming paradigms, large (64-bit) address spaces, and memory-mapped files have led some to propose the use of a single virtual-address space, shared by all processes and processors. To simplify address-space management, some have claimed that a 64-bit address space is sufficiently large that there is no need to ever re-use addresses. Unfortunately, there has been no data to either support or refute these claims, or to aid in the design of appropriate address-space management poli- cies. In this paper, we present the results of extensive kernel-level tracing of the workstations on our campus, and discuss the implications for single-address-space operating systems. V/e found that single-address-space systems will probably not outgrow the available ad- dress space, but only if reasonable space-allocation policies are used, and only if the system can adapt as larger address spaces become available.
Performance Evaluation of Local Features for Large-scale Image Recognition (2008)

Various interest points/regions detectors and local descriptors have been proposed for image recognition. However, it is still unclear which interest points/regions detector or local descriptor gives the best performance for large-scale image recognition of object instances(specific objects). In this report, we present the results of comparison about performance of image recognition with several interest points/regions detectors and local descriptors using a 10,000 image-database. In our experiment, we confirmed that it was the best to employ Hessian-Affine Region as the interest points/regions detector and GLOH/Shape Context as the local descriptor. And PCA-SIFT, providing the functions of both the detector and the descriptor, gives the best performance as the combinational method. In addition, we confirmed that the tendency of misrecognition is different even if the same local descriptor is employed, in case of employing interest regions computed with another detector, furthermore, combination of detectors gives higher accuracy.
One and Two Port Piezoelectric Contour-Mode MEMS Resonators for Frequency Synthesis (2006)

This paper reports on the design, fabrication and testing of novel one and two port piezoelectric contour-mode MEMS resonators that can be employed in RF wireless communications as frequency reference elements or arranged in arrays to form filterbanks. The paper offers a comparison of one and two port resonant devices exhibiting frequencies ranging from 80 to 800 MHz, quality factors from 1,000 to 4,000 in air and motional resistances ranging from 25 to 200 Omega. Fundamental advantages and limitations of each solution are discussed. Experimental results regarding a novel implementation of an 800 MHz one port resonators and a new class of two-port stacked contour resonators are presented
128-bit spectral processing of sub-picosecond optical pulses in a standard SOI CMOS process (2016)

Optical short pulse processors enable several systems including optical code division multiple access networks, optical secure communications, and optical pulse shapers. For instance, compact and low cost integrated solutions for optical short pulse en/de-coders with large code length and capable of processing large optical bandwidth may enable realization of Tbps communication networks. Here, we report an integrated 128-bit short pulse processor capable of signal processing on large amount of optical bandwidth, demonstrated ≈ 25 nm, using sub-ps optical short pulse signal. The chip fabricated in a commercial foundry SOI CMOS process and includes more than 500 distinct optical components and over 150,000 distinct electrical components.
Microwave-Assisted Cyanation of an Aryl Bromide Directly on a Metal−Organic Framework (2011)

A microwave-assisted postsynthetic modification (PSM) reaction on a metal-organic framework (MOF) has been realized. Cyanation of the Zr(4+)-based UiO-66-Br was achieved with CuCN and microwave irradiation to produce UiO-66-CN. This protocol represents a notable example of PSM on an aryl halide MOF producing a cyano-functionalized MOF.
Molecular and phenotypic characterization of Als1 and Als2 mutations conferring tolerance to acetolactate synthase herbicides in soybean (2014)

Although the Als1 and Als2 genes are unlinked, the combination of these two mutations is synergistic for improved tolerance of soybeans to ALS-inhibiting herbicides.
<title>Optical imaging fiber-based recombinant bacterial biosensor</title> (2002)

A cell array biosensor was developed, composed of thousands of individual bacteria cells expressing a reporter gene that responds to the presence of environmental pollutants. The single cell array was produced by immobilizing the cells on an optical imaging fiber. A high-density array of microwells was fabricated on the optical imaging fiber's distal face by selectively etching the individual fibers cores. Each microwell was used to accommodate a single living bacterium, allowing simultaneous monitoring of the genetic responses of all the cells in the array. The optical imaging fiber cell array platform provides a powerful tool for the fabrication of whole cell biosensors for various environmental and industrial applications.
Optimization of semipolar GaInN/GaN blue/green light emitting diode structures on {1-101} GaN side facets (2008)

Bluish-green semipolar GaInN/GaN light emitting diodes (LEDs) were investigated as possible candidates for high-brightness devices even in the long wavelength visible regime. To combine the high material quality known from c-GaN and the advantages of a reduced piezoelectric field, the LED structures were realized on the {1¯101} side facets of selectively grown GaN stripes with triangular cross section. Structural investigations using transmission electron microscopy, scanning electron microscopy, high resolution x-ray diffraction, and atomic force microscopy have been performed and could be related to the luminescence properties in photoluminescence and cathodoluminescence. The defect-related luminescence peaks at 3.3 eV and 3.42 eV typically observed in planar non- and semipolar GaN structures as fingerprints of prismatic and basal plane stacking faults, respectively, could be eliminated in our facet LED structures by optimized growth conditions. Furthermore, an indium incorporation efficiency for these {1¯101} facets is found to be about 50% higher as compared to c-plane growth, what helps significantly to achieve longer wavelength emission in spite of the reduced quantum confined Stark effect in such non- and semipolar materials. Combining these findings, we could realize a bluish-green semipolar light emitting diode on the side facets of our GaN stripes. Continuous wave on-wafer optical output powers as high as 240 µW@20mA could be achieved for about 500nm emission wavelength in electroluminescence measurements. The external efficiency was nearly constant for the investigated current range. Furthermore, the relatively small wavelength shift of about 3 nm for currents between 10mA and 100mA confirmed the reduced piezoelectric field in our LED structures.
Differential Effects of β-catenin and NF-κB Interplay in the Regulation of Cell Proliferation, Inflammation and Tumorigenesis in Response to Bacterial Infection (2013)

Both β-catenin and NF-κB have been implicated in our laboratory as candidate factors in driving proliferation in an in vivo model of Citrobacter rodentium (CR)-induced colonic crypt hyper-proliferation and hyperplasia. Herein, we test the hypothesis that β-catenin and not necessarily NF-κB regulates colonic crypt hyperplasia or tumorigenesis in response to CR infection. When C57Bl/6 wild type (WT) mice were infected with CR, sequential increases in proliferation at days 9 and 12 plateaued off at day 19 and paralleled increases in NF-κB signaling. In Tlr4(-/-) (KO) mice, a sequential but sustained proliferation which tapered off only marginally at day 19, was associated with TLR4-dependent and independent increases in NF-κB signaling. Similarly, increases in either activated or total β-catenin in the colonic crypts of WT mice as early as day 3 post-infection coincided with cyclinD1 and c-myc expression and associated crypt hyperplasia. In KO mice, a delayed kinetics associated predominantly with increases in non-phosphorylated (active) β-catenin coincided with increases in cyclinD1, c-myc and crypt hyperplasia. Interestingly, PKCζ-catalyzed Ser-9 phosphorylation and inactivation of GSK-3β and not loss of wild type APC protein accounted for β-catenin accumulation and nuclear translocation in either strain. In vitro studies with Wnt2b and Wnt5a further validated the interplay between the Wnt/β-catenin and NF-κB pathways, respectively. When WT or KO mice were treated with nanoparticle-encapsulated siRNA to β-catenin (si-β-Cat), almost complete loss of nuclear β-catenin coincided with concomitant decreases in CD44 and crypt hyperplasia without defects in NF-κB signaling. si-β-Cat treatment to Apc(Min/+) mice attenuated CR-induced increases in β-catenin and CD44 that halted the growth of mutated crypts without affecting NF-κB signaling. The predominant β-catenin-induced crypt proliferation was further validated in a Castaneus strain (B6.CAST.11M) that exhibited significant crypt hyperplasia despite an attenuated NF-κB signaling. Thus, β-catenin and not necessarily NF-κB regulates crypt hyperplasia in response to bacterial infection.
Cis‐Platinum Chemotherapy in Head and Neck Cancers (1978)

Sixteen patients with advanced head and neck carcinomas were treated with cis-diaminedichloro platinum chemotherapy; seven preoperatively and nine for recurrent disease. Cis-platinum was given by 24-hour infusions of 80 mg/m2 every three weeks. There was 50% regression in 38% (6) of the patients; another 38% (6) had 25% to 50% regression. Toxicity was minimal, with vomiting occurring in 75% (12) of the courses, renal toxicity in 6% (2), leukopenia in 13% (4), thrombocytopenia in 9% (3), and anemia in 31% (10). Of the seven patients who had serial audiograms, only one experienced ototoxicity. Cis-platinum, given by 24-hour infusion, was effective in reducing tumor bulk in 75% (12) of the patients, with advanced head and neck carcinomas, without undue morbidity.
Moses Efimovich Bergolts: first rector of the revived institute (2020)

The St. Petersburg chemical and pharmaceutical Institute has passed several periods in its development. After the difficult but glorious formation of the Petrograd chemical and pharmaceutical Institute in 1919-1924, the time came for its existence as a faculty within the Leningrad University, and from 1925-the 1st Leningrad medical Institute
Intelligent wind power smoothing control with BESS (2016)

An intelligent wind power smoothing control using recurrent fuzzy neural network (RFNN) is proposed in this study. First, the modeling of wind power generator and the designed battery energy storage system (BESS) are introduced. The BESS is consisted of a bidirectional interleaved DC/DC converter and a 3‐arm 3‐level inverter. Then, the network structure of the RFNN and its online learning algorithms are described in detail. Moreover, actual wind data is adopted as the input to the designed wind power generator model. Furthermore, the three‐phase output currents of the wind power generator are converted to dq ‐axis current components. The resulted q ‐axis current is the input of the RFNN power smoothing control and the output is a gentle wind power curve to achieve the effect of wind power smoothing. The difference of the actual wind power and smoothed power is supplied by the BESS. The minimum energy capacity of the BESS with a small fluctuation of the grid power can be achieved by the RFNN power smoothing control. A digital signal processor (DSP) based BESS is built using two TMS320F28335. From the experimental results of various wind variation sceneries, the effectiveness of the proposed intelligent wind power smoothing control is verified.
CRAC channel inhibition by RP3128 ameliorates airway hyper-reactivity in antigen sensitized mice and guinea pigs (2014)

Introduction Calcium release activated calcium (CRAC) channel inhibitors have a potent role in treatment of respiratory disorders. RP3128 is a novel CRAC channel inhibitor exhibiting nanomolar potency against ICRAC and immune-modulatory activity across relevant pre-clinical assays. The objective of the current study was to explore and elucidate the anti-asthmatic properties of RP3128 in allergen-challenged mice and guinea pigs. Methods Suppression of antigen-induced asthmatic responses upon oral administration of RP3128 in Balb/c mice and guinea pigs were determined. Changes in ASM reactivity in response to RP3128 in vitro were tested using an organ-bath method. Results Oral administration of RP3128 to sensitized mice resulted in attenuation of methacholine induced airway hyperresponsivness manifested by dose-dependent reduction in PenH (∼50% @ 3 mg/kg) values as well as eosinophil count (ED 50 = 1.9 mg/kg). RP3128 significantly reduced basal (71%) and histamine (86%) or methacholine (87%) induced sRaw values in sensitized guinea pigs. Besides, RP3128 caused a near complete inhibition of ENO levels as well as reduction in serum (IL-4, IL-13, and TNFα) and BALF (IL-4, IL-5, IL-13, and TNFα) cytokines (50-95%). Additionally, contraction amplitude of isolated tracheal or pulmonary smooth muscle in response to cumulative doses of acetylcholine or histamine was significantly reduced in RP3128 treated animals compared to saline control group. Conclusions Data demonstrate the anti-inflammatory and airway remodelling properties of RP3128 upon administration at a low dose thereby indicating the therapeutic potential of this molecule in respiratory disorders.
Advanced calibration and normalization techniques for time domain reflection and transmission measurements (2002)

The authors present a new advanced data-processing technique for error correction of the time domain network analyzer. The approach reduces the systematic errors of the time domain network analyzer significantly. The error correction is based on a frequency domain twoport error model. All measurements proceed in the time domain, while the error correction itself proceeds completely in the frequency domain. The calibration and normalization software package TTRECS is not restricted to the calculation of the normalized time domain signals, but the corrected frequency domain S-parameters can also be found.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>