gebhart/patrepeval huggingface dataset:
Abstract 722: Evaluation of a chimeric anti CEA-conjugated antibody with AlexaFlour or Dylight fluorescent dyes for imaging pancreatic cancer in orthotopic nude mouse models. (2013)

Abstract In this study, we evaluated multiple wavelengths of different fluorophores of the AlexaFlour (Invitrogen) and Dylight (Thermofisher scientific) series of fluorescent probes for labeling of mouse models of pancreatic cancer. BxPC-3 human pancreatic cancer cells were cultured in-vitro and subsequently injected subcutaneously in nude mice. After the development of subcutaneous tumors, the tumors were harvested and orthotopically implanted into the pancreatic tails of nude mice (1x1 mm fragments). The following fluorescent dyes were evaluated: 488 group (Alexa 488 and Dylight 488); 550 group (Alexa 555 and Dylight 550); 650 group (Alexa 660 and Dylight 650). The dyes were conjugated to chimeric anti-CEA antibody at a ratio of 3-4moles of dye per mole of protein. 50-100 μg of the fluorophore conjugated antibody was injected per mouse intravenously. Mice were then imaged with the OV100 Small Animal Imager (Olympus Corp, Tokyo, Japan). Whole body and intravital imaging were done at various time points (post implantation day 7-14). Mice that had tumor visible on whole body imaging were sacrificed, after which tumor depth, size, weight and fluorescence intensity were recorded. The smallest tumor size was first discernible on whole body imaging with the 650 group of dyes, followed by the 550 group and finally the 488 group with significantly larger tumors. The fluorescence intensity of the Dylight panel of dyes overall was brighter than the AlexaFluor dyes and therefore able to detect smaller and deeper tumors. The 550 and 650 group of dyes had the least amount background fluorescence with the highest amount of tumor to normal tissue contrast. In evaluation of tumor depth the 650 group of dyes were able to detect the deepest tumors; of the group the 488 group had the least tissue penetrance. In this study, the Dylight group of dyes had brighter conjugates with better tissue penetration and tumor delineation when compared to the AlexaFluor dyes. The 650 group of dyes had the most tissue penetration. The 550 group of dyes had similar background autofluorescence to the 650 group that was signficantly less than the 488 group. Both the 550 and 650 group had the highest tumor to background ratio of fluoresence that allows for very high fidelity in the delineation of neoplastic tissue from normal tissue. Citation Format: Ali A. Maawy, Sharmeela Kaushal, Cynthia S. Snyder, George A. Luiken, Mark A. Talamini, Robert M. Hoffman, Michael Bouvet. Evaluation of a chimeric anti CEA-conjugated antibody with AlexaFlour or Dylight fluorescent dyes for imaging pancreatic cancer in orthotopic nude mouse models. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 722. doi:10.1158/1538-7445.AM2013-722
Impact of Preferential P-Diffusion Along the Grain Boundaries on Fine-Grained Polysilicon Solar Cells (2007)

Thin-film polysilicon solar cells are a promising low-cost alternative for bulk silicon solar cells due to their reduced material thickness. Recently, we showed that the use of an amorphous silicon/polycrystalline silicon heterojunction emitter instead of a diffused homojunction emitter led to a boost in the open-circuit voltage by 90 mV. Now, we present a full evidence that shows that this improvement is related to the absence of dopant smearing along the grain boundaries. By using scanning spreading resistance microscopy, we found an enlargement of the junction area by a factor of five in case of a homojunction. The tips of the dopant spikes represent lowly doped areas with an enhanced recombination.
Resistive-Aware Linear Approximations for Solving the Optimal Power Flow Problem for Distribution Networks (2019)

Although notable progress has been made to solve the Alternate Current (AC) Optimal Power Flow (OPF), the Direct Current (DC) and Decoupled OPF approximations are still preferable in broad scenarios of practical interest. These approximations typically assume that the resistive nature of the lines in the power system is negligible. This work discusses modifications of these assumptions and presents new approximations of the DC and Decoupled OPF in light of distribution systems, in which line resistances may not be negligible. The Enhanced DC (EDC) OPF and Coupled OPF (COPF) approximations are introduced and assessed, presenting favorable results compared to their classic counterparts.
Modified technique for neurovascular bundle preservation during radical prostatectomy: association between technique and recovery of erectile function (2008)

Technical modifications to NVB preservation during RP were associated with improved rates of EF recovery.
Sequence variants within exon 1 of MECP2 occur in females with mental retardation (2006)

A new splice variant of the Rett syndrome gene, MECP2, was recently identified, that includes coding sequence from exon 1, and is the predominant transcript in the central nervous system. This sequence encodes polyalanine and polyglycine stretches within the N-terminal portion of MeCP2, and may confer novel functional properties to the protein. We screened autism, mental retardation (MR), and control populations for sequence variation within this region, and identified variation in approximately 1% of MR cases screened (N = 1,410). No variants were identified in the autism sample (N = 401). Most of these variants occur within a trinucleotide repeat region and result in change in number of alanine or glycine residues within the repeat stretches. We suggest some of these variants may be a relatively frequent cause of non-specific MR or developmental delay.
Effects of Electric-Field Shape and Frequency on Smectic Layer Rotation of Siloxane Ferroelectric Liquid Crystals (2007)

Smectic layer rotations in ferroelectric liquid crystals (FLC) upon application of electric fields have been observed only in chiral smectic phases and believed to be related to the electroclinic effect. In this article, effects of electric field shape and frequency on smectic layer rotations in siloxane-based FLCs were investigated by applying various kinds of asymmetric ac waveforms for a range of frequencies and temperatures. For a given peak voltage, we have found that the asymmetry was one of the most important parameters and demonstrated that the modified step form showed the best efficiency for smectic layer rotations.
Optimization of retardance for a complete Stokes polarimeter (2000)

We present two figures of merit based on singular value decomposition, which can be used to assess the noise immunity of a complete Stokes polarimeter. These are used to optimize a polarimeter featuring a rotatable retarder and a fixed polarizer. A retardance of 132 degrees (approximately three-eighths wave) and retarder orientation angles of +/-51.7 degrees and +/-15.1 degrees are found to be optimal when four measurements are used. Use of this retardance affords a factor-of-1.5 improvement in signal-to-noise ratio over systems employing a quarter-wave plate. A geometric means of visualizing the optimization process is discussed, and the advantages of the use of additional measurements are investigated. No advantage of using retarder orientation angles spaced uniformly through 360 degrees is found over repeated measurements made at the four retarder orientation angles.
Progress in Nickel Silicide Formation Using Excimer Laser Annealing: A Simulation Study (2012)

In this work, we used a finite element model to simulate a novel nickel silicide formation process based on Excimer Laser Annealing (ELA). We evaluate the robustness of this new metallization process scheme that is selfaligned and compatible with shallow emitters. Study structures have been irradiated by ELA at several densities of energy, and also modelled into the simulation program. The results were compared and we suggest an explanation for the nickel silicidation process. The simulation results show a strong dependence of the energy density threshold to melt silicon with the thickness of the studied capping layer: Ni or SiNx. This is directly related to the reflectance of the stacks at the wavelength of the UV laser, but also to the thermal conductivity K and heat capacity cp of the materials. Phosphorus profiles after ELA can be predicted but the model still needs a calibration to match perfectly with the experience. A process path for self-aligned NiSi alloying with Excico laser system through full sheet ELA on real solar cells has been found. This has been confirmed with the realization of PERC cells with conversion efficiency up to 20%.
Cardiac free wall rupture in acute myocardial infarction: Ameliorative effect of coronary reperfusion (1992)

To investigate the pathophysiology of cardiac free wall rupture (cardiac rupture) following acute myocardial infarction (AMI), and to clarify whether reperfusion therapy prevents cardiac rupture, 1,329 cases of AMI (conventional therapy group: 807 cases and reperfusion therapy group: 533 cases) were studied retrospectively. The overall incidence of cardiac rupture was 2.3% (2.7% in the conventional therapy group vs. 1.7% in the reperfusion therapy group). Patients with cardiac rupture were divided into two subgroups according to the time interval from the onset of AMI to cardiac rupture (early rupture less than or equal to 72 h and late rupture greater than or equal to 4 days). The indices of initial evolution of AMI was a significant risk of early cardiac rupture. The reperfusion therapy group showed significantly lower incidence of late rupture (0.4 vs. 1.5% in conventional therapy group; p less than 0.05). The incidence of cardiac rupture in the unsuccessful reperfusion therapy group was higher than that of the successful group (5.9% of 118 cases vs. 0.5% of 404 cases; p less than 0.05). It is concluded that the etiology of cardiac rupture following AMI cannot be explained by any single factor. Early rupture depends on the initial evolution of AMI, and early reperfusion and collateral flow prevent the late onset cardiac rupture.
Reversible Luminescent Gels Containing Metal Complexes (2007)

Abstract Gelators are compounds capable of solidifying various solvents and water. Organic gels, and in particular hydrogels, are interesting soft materials with many potential applications. In this paper the formation of luminescent gels in water and dimethylformamide as solvents is reported. The gels are prepared by using a carboxylate‐based aliphatic gelator ( 1 ) and a N , N ′‐bis( O ‐methyl‐TyrOH) oxalamide derivative ( 2 ). The gels are transparent, and form fiberlike structures in the presence of the red luminescent moiety, a Eu III hemicaged complex. The spectroscopic behavior of the complex is investigated in different solvents and when is entrapped in the gel. In order to probe the involvement of the chemical structure of the luminescent moiety in the gel network, a ruthenium complex, Ru(bpy) 2 (dppz) 2+ (where bpy = 2,2′‐bipyridine and dppz = dipyrido[3,2‐ a :2′,3′‐ c ]phenazine) has also been employed. The complex is in fact nonluminescent in water, while emitting when incorporated in the gel. Such “switching on” behavior is attributed to the incorporation of the complex into the lipophilic environment of gel fibers, where it is shielded from quenching by water molecules.
Optimierung der Herstellung von Biotensiden auf Basis nachwachsender Rohstoffe (2010)

Abstract Ein Konzept zur Prozessentwicklung und ‐optimierung von biotechnologischen Produkten wurde am Beispiel der Herstellung von Sophoroselipiden entwickelt. Neben der mikrobiellen Herstellung mit produktionsintegrierter Produktabtrennung mittels Sedimentation wurde in dieser Arbeit die Extraktion im Rahmen der Grundoperationenauswahl als Aufreinigungsoption experimentell untersucht.
Enhanced methanol oxidation and oxygen reduction reactions on palladium-decorated FeCo@Fe/C core–shell nanocatalysts in alkaline medium (2013)

Palladium based nano-alloys are well known for their unique electrocatalytic properties. In this work, a palladium-decorated FeCo@Fe/C core-shell nanocatalyst has been prepared by a new method called microwave-induced top-down nanostructuring and decoration (MITNAD). This simple, yet efficient technique, resulted in the generation of sub-10 nm sized FeCo@Fe@Pd nanocatalysts (mainly 3-5 nm) from a micron-sized (0.21-1.5 μm) FeCo@Fe/C. The electrocatalytic activities of the core-shell nanocatalysts were explored for methanol oxidation reaction (MOR) and oxygen reduction reaction (ORR) in alkaline medium. A negative shift of 300 mV in the onset potential for MOR was observed, with a current thrice that of the Pd/C catalysts. A very low resistance to electron transfer (Rct) was observed while the ratio of forward-to-backward oxidation current (If/Ib) was doubled. The overpotential of ORR was significantly reduced with a positive shift of about 250 mV and twice the reduction current density was observed in comparison with Pd/C nanocatalysts with the same mass loading. The kinetic parameters (in terms of the Tafel slope (b) = -59.7 mV dec(-1) (Temkin isotherm) and high exchange current density (jo) = 1.26 × 10(-2) mA cm(-2)) provide insights into the favorable electrocatalytic performance of the catalysts in ORR in alkaline media. Importantly, the core-shell nanocatalyst exhibited excellent resistance to possible methanol cross-over during ORR, which shows excellent promise for application in direct alkaline alcohol fuel cells (DAAFCs).
Optically amplified WDM ring network incorporating channel-dropping filters (1994)

Optical ring networks are quite useful for interconnecting many network nodes. However, when the signal tapping loss at each node is combined with fiber-attenuation and component-insertion losses (~4 dB), the number of 2.5-Gbit/s nodes in a typical ring is limited to &lt;6. Optical amplifiers [i.e., erbium- doped fiber amplifiers (EDFAs)] must be incorporated to compensate for these losses. Additionally, the network capacity is significantly enhanced by transmitting many wavelength-division-multiplexed (WDM) channels.1-3 However, incorporating WDM into an amplified ring is complicated by the wavelength dependence of the EDFA gain.
Has the Time for EMT Finally Come? (2019)

It is argued that a large portion of system development in the modern computer era has been based on the mismatch assumption of slow "peripheral" storage, fast memory, and even faster CPU, the so-called memory hierarchy. This assumption has slowly been crumbling as the gap between slow storage and fast memory narrows with the advent of flash memory.
Self-collimation in planar photonic crystals (2002)

We analyze, in three dimensions, the dispersion properties of dielectric slabs perforated with two-dimensional photonic crystals (PCs) of square symmetry. The band diagrams are calculated for all k-vectors in the first Brillouin zone, and not only along the characteristic high-symmetry directions. We have analyzed the equal-frequency contours of the first two bands, and we found that the square lattice planar photonic crystal is a good candidate for the self-collimation of light beams. We map out the group velocities for the second band of a square lattice planar PC and show that the group velocity is the highest in the region of maximum self-collimation. Such a self-collimated beam is predicted to show beating patterns due to the specific shape of the equal-frequency contours. A geometrical transformation maps the region of the first and second photonic bands where self-collimation takes place one onto the other and gives additional insights on the structural similarities of self-collimation in those two bands.
Theoretical Prediction of the Thermochemistry and Kinetics of Reactions of CF2O with Hydrogen Atom and Water (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTheoretical Prediction of the Thermochemistry and Kinetics of Reactions of CF2O with Hydrogen Atom and WaterM. R. Zachariah, W. Tsang, P. R. Westmoreland, and D. R. F. Burgess Jr.Cite this: J. Phys. Chem. 1995, 99, 33, 12512–12519Publication Date (Print):August 1, 1995Publication History Published online1 May 2002Published inissue 1 August 1995https://pubs.acs.org/doi/10.1021/j100033a023https://doi.org/10.1021/j100033a023research-articleACS PublicationsRequest reuse permissionsArticle Views167Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
No association of migraine to the GABA‐A receptor complex on chromosome 15 (2007)

To date, no gene variants predisposing to common forms of migraine have been convincingly identified. Recently, significant linkage to a cluster of gamma-amino butyric acid (GABA)-A receptors on Chr 15q11-q13 was reported. We performed an extensive association study using 898 MA cases and 900 matched controls by covering the same gene cluster with 34 single nucleotide polymorphisms (SNPs). No association to MA was detected, suggesting that common variants of the GABA cluster are unlikely to be major contributors of MA susceptibility.
Superconducting Optoelectronic Neurons III: Synaptic Plasticity (2018)

As a means of dynamically reconfiguring the synaptic weight of a superconducting optoelectronic loop neuron, a superconducting flux storage loop is inductively coupled to the synaptic current bias of the neuron. A standard flux memory cell is used to achieve a binary synapse, and loops capable of storing many flux quanta are used to enact multi-stable synapses. Circuits are designed to implement supervised learning wherein current pulses add or remove flux from the loop to strengthen or weaken the synaptic weight. Designs are presented for circuits with hundreds of intermediate synaptic weights between minimum and maximum strengths. Circuits for implementing unsupervised learning are modeled using two photons to strengthen and two photons to weaken the synaptic weight via Hebbian and anti-Hebbian learning rules, and techniques are proposed to control the learning rate. Implementation of short-term plasticity, homeostatic plasticity, and metaplasticity in loop neurons is discussed.
Impaired energetics and normal myocardial lipids in rheumatoid arthritis and systemic lupus erythematosus: a phosphorous and proton magnetic resonance spectroscopy and cardiovascular magnetic resonance study (2015)

Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) commonly involve the cardiovascular system and are associated with significant morbidity and mortality, driven by cardiovascular inflammation, microvascular and diastolic dysfunction and fibrosis. Cardiovascular magnetic resonance (CMR) can assess non-invasively cardiac function, strain, ischaemia, altered vascular function, perfusion, inflammation and fibrosis; magnetic resonance spectroscopy (MRS) provides further insights into the status of myocardial energetics and lipidosis. To date, there have been no cardiovascular MRS studies in RA and SLE patients. We hypothesised that RA and SLE would be associated with impaired myocardial energetics and lipidosis.
Carboxymethylated Polyvinyl Alcohol Stabilizes Doped Ferrofluids for Biological Applications (2010)

Highly magnetic MnFe2O4 nanocrystals (NCs) are coated with non-cross-linked carboxymethyl polyvinyl alcohol to produce conjugates that are highly stable under varying temperatures, pH, and ionic strengths. The polymer-coated NCs exhibit low nonspecific cell binding. They are also amenable to chemical linking with biomolecules, allowing for the efficient labeling of surface receptors on targeted cancer cells in vitro. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Pulsed electron avalanche knife for capsulotomy in congenital and mature cataract (2006)

The pulsed electron avalanche knife (PEAK-fc, Carl Zeiss Meditec) is an electrosurgical cutting device that allows precise "cold" and traction-free tissue dissection. We describe its applicability and safety for anterior capsulotomy in a child with congenital cataract and an adult patient with mature cataract. The PEAK-fc was set at a voltage of 600 V and a pulse repetition rate of 80 Hz. Anterior capsulotomies were successfully and safely performed in both cases, with the edges of capsulotomies appearing sharp and showing only limited collateral damage. The PEAK-fc appears to be a helpful cutting device for complicated cases of cataract surgery, especially for mature and congenital cataracts.
Effect of Doping on the Ionic Conductivity and Bonding of Reactively Sputter Deposited Lithium Phosphorus Oxynitride Thin Films (2012)

Abstract not Available.
Abstract 15237: Alterations in the Human Mitral Valve in-vivo Functional State in Mitraclip Repair (2022)

Introduction: The MitraClip for treatment of mitral regurgitation (MR) is a generally safe and effective procedure. However, recent clinical trials have reported contradictory outcomes, and long-term efficacy remains almost completely unknown. Therefore, there is an urgent need for quantitative, patient-specific treatment optimization grounded on a robust understanding of the functional consequences of the MitraClip repair procedure on each patient-specific mitral valve (MV). Methods: Real-time 3D echocardiography images of ten MR patients’ MVs were acquired during the MitraClip procedure. These images were analyzed using our validated noninvasive strain estimation method to compute the pre-operative leaflet strain fields in the circumferential and radial directions. For the post-operative analysis, 3D MitraClip models were implemented in the corresponding size and number in the simulation to directly grasp the MV leaflets at echo-dictated positions. Results: The MV pre-surgical states were highly variable in both geometry and deformation, underscoring the heterogeneity of the MR in the patient population. There were also no consistent post-surgical global or local strain patterns between MVs. However, the pre- and post-surgical strain fields in the same MV were significantly better correlated than random pre- and post-surgical pairs (p &lt; 0.005). This quantitative result implies that the post-surgical state for each patient can be predicted from available pre-surgical data-derived modelling. Conclusions: Due to the highly variable pre-surgical state of regurgitant MVs, a patient-specific approach to MitraClip repair is crucial to improving long-term patient outcomes. Moreover, these findings suggest that the post-surgical state can be correlated to, and therefore predicted from, the pre-surgical state, which would lay the foundation for quantitative surgical planning, tailored patient selection, and ultimately, a more durable repair.