gebhart/patrepeval huggingface dataset:
COST ANALYSIS OF OVERACTIVE BLADDER TREATMENTS FOR ORAL ANTIMUSCARINIC REFRACTORY PATIENTS (2008)

You have accessJournal of Urology1 Apr 2008COST ANALYSIS OF OVERACTIVE BLADDER TREATMENTS FOR ORAL ANTIMUSCARINIC REFRACTORY PATIENTS Jonathan H Watanabe, Jonathan D Campbell, Arliene Ravelo, Michael B Chancellor, Jonathan W Kowalski, and Sean D Sullivan Jonathan H WatanabeJonathan H Watanabe More articles by this author , Jonathan D CampbellJonathan D Campbell More articles by this author , Arliene RaveloArliene Ravelo More articles by this author , Michael B ChancellorMichael B Chancellor More articles by this author , Jonathan W KowalskiJonathan W Kowalski More articles by this author , and Sean D SullivanSean D Sullivan More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(08)60165-2AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "COST ANALYSIS OF OVERACTIVE BLADDER TREATMENTS FOR ORAL ANTIMUSCARINIC REFRACTORY PATIENTS." The Journal of Urology, 179(4S), pp. 55–56 © 2008 by American Urological AssociationFiguresReferencesRelatedDetails Volume 179Issue 4SApril 2008Page: 55-56 Advertisement Copyright & Permissions© 2008 by American Urological AssociationMetricsAuthor Information Jonathan H Watanabe More articles by this author Jonathan D Campbell More articles by this author Arliene Ravelo More articles by this author Michael B Chancellor More articles by this author Jonathan W Kowalski More articles by this author Sean D Sullivan More articles by this author Expand All Advertisement PDF downloadLoading ...
Abstract 259: A Microrna Pathway That Promotes Cardiomyocyte Proliferation And Cardiac Regeneration By Inhibiting Hippo Signaling (2014)

In contrast to lower vertebrates, the mammalian heart has limited capacity to regenerate after injury in part due to ineffective reactivation of cardiomyocyte proliferation. While evidence exists for a low level of cardiomyocyte proliferation in the adult heart, it remains unclear whether increasing the rate could be used to therapeutically promote cardiac regeneration. In this study, we show that the microRNA cluster miR302-367 is important for cardiomyocyte proliferation during development and is sufficient to induce cardiomyocyte proliferation in the adult and promote cardiac regeneration. Loss of miR302-367 leads to decreased cardiomyocyte proliferation during development. In contrast, increased miR302-367 expression leads to a profound increase in cardiomyocyte proliferation, in part through repression of the Hippo signal transduction pathway. Postnatal re-expression of miR302-367 leads to reactivation of the cell cycle in cardiomyocytes resulting in reduced scar formation after infarction. However, long-term expression of miR302-367 leads to cardiomyocyte de-differentiation and dysfunction, suggesting that persistent reactivation of the cell cycle in postnatal cardiomyocytes is not desirable. Importantly, this limitation can be overcome by transient systemic application of miR302-367 mimics, leading to increased cardiomyocyte proliferation and mass, decreased fibrosis, and improved function after injury. Our data demonstrate the ability of microRNA based therapeutic approaches to promote cardiac repair and regeneration through the transient activation of cardiomyocyte proliferation.
The BRAIN Initiative: developing technology to catalyse neuroscience discovery. (2015)

The evolution of the field of neuroscience has been propelled by the advent of novel technological capabilities, and the pace at which these capabilities are being developed has accelerated dramatically in the past decade. Capitalizing on this momentum, the United States launched the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative to develop and apply new tools and technologies for revolutionizing our understanding of the brain. In this article, we review the scientific vision for this initiative set forth by the National Institutes of Health and discuss its implications for the future of neuroscience research. Particular emphasis is given to its potential impact on the mapping and study of neural circuits, and how this knowledge will transform our understanding of the complexity of the human brain and its diverse array of behaviours, perceptions, thoughts and emotions.
Quantitative analysis of multilayer organization of proteins and RNA in nuclear speckles at super resolution (2017)

Nuclear speckles are self-assembled organelles composed of RNAs and proteins. They are proposed to act as structural domains that control distinct steps in gene expression, including transcription, splicing and mRNA export. Earlier studies identified differential localization of a few components within the speckles. It was speculated that the spatial organization of speckle components might contribute directly to the order of operations that coordinate distinct processes. Here, by performing multi-color structured illumination microscopy, we characterized the multilayer organization of speckles at a higher resolution. We found that SON and SC35 (also known as SRSF2) localize to the central region of the speckle, whereas <i>MALAT1</i> and small nuclear (sn)RNAs are enriched at the speckle periphery. Coarse-grained simulations indicate that the non-random organization arises due to the interplay between favorable sequence-encoded intermolecular interactions of speckle-resident proteins and RNAs. Finally, we observe positive correlation between the total amount of RNA present within a speckle and the speckle size. These results imply that speckle size may be regulated to accommodate RNA accumulation and processing. Accumulation of RNA from various actively transcribed speckle-associated genes could contribute to the observed speckle size variations within a single cell.
A molecularly engineered fluorene-substituted Ru-complex for efficient mesoscopic dye-sensitized solar cells (2011)

A new high molar extinction coefficient ruthenium(II) bipyridyl complex 'cis-Ru(L1)(2,2'-bipyridine-4,4'-dicarboxylic acid) (NCS)2, BDF', where L1=4,4-bis(9,9-dibutyl-9H-fluorene-2-yl)-[2,2] bipyridine, has been synthesized and characterized by Fourier transform infrared (FTIR), hydrogen nuclear magnetic resonance (1H-NMR) and electrospray ionization mass (ESI–MASS) spectroscopes. The dye, upon anchoring onto mesoporous nano-crystalline TiO2 solar cells, exhibited a broader photocurrent action spectrum, with a solar-to-electric energy conversion efficiency (η) of 6.58% (JSC=14.66 mA cm−2, VOC=640 mV, fill factor=0.71) under sunlight at air mass (AM) 1.5, larger than the reference Z907 sensitized solar cell fabricated under similar conditions, which exhibited an η-value of 4.65% (JSC=11.52 mA cm−2, VOC=566 mV, fill factor=0.72). Absorption measurements and time-dependent density functional theory (TDDFT) calculations show that the increased conjugation length by introducing 9,9-dibutyl-9H-fluorene moiety relatively enhances the spectral response of the ancillary ligand and the corresponding BDF complex. The calculated dipole moments for BDF and Z907 are 17.71 and 16.34 Debye, respectively. The first three highest occupied molecular orbitals (HOMOs) of BDF have a t2g character, as observed in Z907, while HOMO-4 and HOMO-5 have considerable sizable mixing from Ru-NCS with π-orbitals of L1.
Attribution Methods Reveal Flaws in Fingerprint-Based Virtual Screening (2020)

Fingerprint-based models for protein-ligand binding have demonstrated outstanding success on benchmark datasets; however, these models may not learn the correct binding rules. To assess this concern, we use in silico datasets with known binding rules to develop a general framework for evaluating model attribution. This framework identifies fragments that a model considers necessary to achieve a particular score, sidestepping the need for a model to be differentiable. Our results confirm that high-performing models may not learn the correct binding rule, and suggest concrete steps that can remedy this situation. We show that adding fragment-matched inactive molecules (decoys) to the data reduces attribution false negatives, while attribution false positives largely arise from the background correlation structure of molecular data. Normalizing for these background correlations helps to reveal the true binding logic. Our work highlights the danger of trusting attributions from high-performing models and suggests that a closer examination of fingerprint correlation structure and better decoy selection may help reduce misattributions.
Synthesis and Insecticidal Activity of New Benzyl- and Indanyl-Oxazolines, Thiazolines and Alkoxy-Alkyl-Imidazolines (2015)

Compounds 1, 2 and 3 are examples of a new chemical class with potent activity against sucking insects, comparable to or greater than commercialised standards. The discovery, synthesis, biology and structure-activity relationships are described herein. Modelling of their distribution in plants encouraged us to invoke “vacuole trapping” to explain the weak field performance of this class of insecticides.
Efficient channel quality feedback schemes for adaptive modulation and coding of packet data (2005)

Adaptive modulation and coding (AMC) is a powerful technique to improve throughput especially of wireless packet-oriented channels. In general such link adaptation schemes rely on feedback from the receiver, which allows selecting the appropriate modulation and coding. In this paper we evaluate the performance of different channel quality feedback schemes and propose a general performance metric, that considers data throughput, energy efficiency, channel resource consumption, as well as control overhead. At the example of the high speed downlink packet access (HSDPA) channel for UMTS FDD, we show that channel quality feedback schemes that consider the burstiness of packet data are able to provide notably higher efficiency than the cyclic feedback currently standardized.
Characterization and Usefulness of Clot-Fibrinolysis Waveform Analysis in Critical Care Patients with Enhanced or Suppressed Fibrinolysis (2023)

The fibrinolysis reaction was detected in all three groups, but the status differed. CFWA has the potential to reflect the fibrinolysis status in one global assay.
β 3 -Integrins Rather Than β 1 -Integrins Dominate Integrin-Matrix Interactions Involved in Postinjury Smooth Muscle Cell Migration (1998)

In postinjury migrating SMCs, beta3- rather than beta1-integrin-matrix interactions are of greater functional significance in adhesive processes essential for SMC migration in vitro and in vivo. Blockade of dominant SMC integrin (beta3)-matrix interactions may be a valuable approach for limiting injury-induced SMC migration and late arterial renarrowing.
Placental apoptosis in preeclampsia (2000)

Placental apoptosis and altered expression of Fas and Fas ligand in trophoblast might influence pathogenesis or sequelae of preeclampsia.
Magnetic vortex state applied in magnetoresistive sensors (Conference Presentation) (2019)

Magnetoresistive sensors based on giant magnetoresistance (GMR) or tunnel magnetoresistance (TMR) play a major role towards the miniaturization in the industrial society. Typically, spin-valve-type magnetoresistive sensors are embedded in a Wheatstone bridge configuration with rectangular, meander-like or elliptically shaped thin film elements. Such elements usually switch via multi-domain, C- or S-shaped magnetization states and, therefore, often exhibit an open non-linear hysteresis curve. Linearity and hysteretic effects are key features in the improvement of such sensors. We will present a different approach by using circularly shaped elements exhibiting a different magnetization state of a magnetic vortex [1]. This is one of the fundamental magnetization ground states occurring in disk-shaped thin film elements and is characterized by minimization of the demagnetizing energy at the expense of exchange energy. Experimental data were generated on electrically contacted GMR and TMR disks which were fabricated by optical lithography. The following advantages will be discussed and compared to standard elliptical sensor elements. (a) The vortex state shows essentially no hysteresis in the minor loop. (b) Since the vortex nucleation happens prior to the zero field, the M(H=0)=0 crossing is independent of history. (c) The critical fields can be easily controlled by the element geometry. (d) The noise is low. All characteristic experimental values have been determined in dependence of free layer thickness, disk diameter and temperature. These findings are discussed in the frame of the semi-analytical rigid-vortex-model [2] and micromagnetic simulations. The financial support by the Austrian Federal Ministry of Science, Research and Economy and the Christian Doppler Research Association in Austria is gratefully acknowledged. [1] D. Suess, A. Bachleitner-Hofmann, A. Satz, H. Weitensfelder, C. Vogler, F. Bruckner, C. Abert, K. Prügl, J. Zimmer, C. Huber, S. Luber, W. Raberg, T. Schrefl, H. Brückl, „Topologically Protected Vortex Structures to Realize Low-Noise Magnetic Sensors with High Linear Range”, Nature Electronics 1, 362 (2018) [2] K. Y. Guslienko et al., “Magnetization reversal due to vortex nucleation, displacement, and annihilation in submicron ferromagnetic dot arrays”, Phys. Rev. B 65 (2001)
Membrane-type metamaterials: Transmission loss of multi-celled arrays (2011)

Acoustic metamaterials with negative dynamic mass density have been shown to demonstrate a five-fold increase in transmission loss (TL) over mass law predictions for a narrowband (100 Hz) at low frequencies (100–1000 Hz). The present work focuses on the scale-up of this effect by examining the behavior of multiple elements arranged in arrays. Single membranes were stretched over rigid frame supports and masses were attached to the center of each divided cell. The TL behavior was measured for multiple configurations with different magnitudes of mass distributed across each of the cell membranes in the array resulting in a multipeak TL profile. To better understand scale-up issues, the effect of the frame structure compliance was evaluated, and more compliant frames resulted in a reduction in the TL peak frequency bandwidth. In addition, displacement measurements of frames and membranes were performed using a laser vibrometer. Finally, the measured TL of the multi-celled structure was compared with the TL behavior predicted by finite element analysis to understand the role of nonuniform mass distribution and frame compliance.
7-Deaza-8-bromo-cyclic ADP-ribose, the First Membrane-permeant, Hydrolysis-resistant Cyclic ADP-ribose Antagonist (1997)

Cyclic ADP-ribose (cADPR) is a putative second messenger that has been demonstrated to mobilize Ca2+ in many cell types. Its postulated role as the endogenous regulator of ryanodine-sensitive Ca2+ release channels has been greatly supported by the advent and use of specific cADPR receptor antagonists such as 8-NH2-cADPR (Walseth, T. F., and Lee, H. C. (1993) Biochim. Biophys. Acta 1178, 235-242). However, investigations of the role of cADPR in physiological responses, such as fertilization, stimulus-secretion coupling, and excitation-contraction coupling, have been hindered by the susceptibility of cADPR receptor antagonists to hydrolysis and the need to introduce these molecules into cells by microinjection or patch clamp techniques. We have recently reported on the discovery of a poorly hydrolyzable analogue of cADPR, 7-deaza-cADPR (Bailey, V. C., Sethi, J. K., Fortt, S. M., Galione, A., and Potter, B. V. L. (1997) Chem. Biol. 4, 41-51) but this, like cADPR, is an agonist of ryanodine-sensitive Ca2+ release channels. We therefore explored the possibility of combining antagonistic activity with that of hydrolytic resistance and now report on the biological properties of the first hydrolysis-resistant cADPR receptor antagonist, 7-deaza-8-bromo-cADPR. In addition this compound has the advantage of being membrane-permeable. Together these properties make this hybrid molecule the most powerful tool to date for studying cADPR-mediated Ca2+ signaling in intact cells.
Age, race and viral genotype are associated with the prevalence of hepatitis B e antigen in children and adults with chronic hepatitis B (2019)

Hepatitis B e antigen (HBeAg) is an important serological marker of hepatitis B virus (HBV) infection and is associated with higher levels of viraemia, increased risk of infectivity to others and increased risk of hepatocellular carcinoma. We analysed HBeAg status in a large cohort of adults and children enrolled in Cohort Studies of the Hepatitis B Research Network, long-term natural history studies of chronic HBV infection. A cross-sectional analysis examined factors associated with HBeAg positivity, including demographic and virologic data, across the age spectrum. Among 2241 enrolled participants who met criteria for this analysis, 825 (37%) were seropositive for HBeAg. The prevalence of HBeAg was lower in those with older age, ranging from 85% among those up to 10 years of age to only 12% among those older than 50 years. In addition to age, both race and HBV genotype were independently associated with HBeAg positivity. There was a significant interaction between age and race; the prevalence of HBeAg was significantly higher among Asians > 10-30 years old vs Whites or Blacks who were >10 to 30 years old and those infected with HBV genotype C. Conversely, the presence of the basal core promoter and precore variants was associated with significantly lower prevalence of HBeAg, even when adjusted for age, race and genotype. These data will provide a better understanding of factors associated with seropositivity for HBeAg and may lead to better strategies for preventing HBV infection and broader indications for antiviral therapy.
Anti-HER-2 therapy following severe trastuzumab-induced cardiac toxicity (2017)

The human epidermal growth factor receptor 2 (HER2) is overexpressed in 25%-30% of breast cancer patients. Anti-HER2 therapies have changed the aggressive course of HER2+ breast cancer. In spite of the therapeutic benefits, their cardiotoxicities are major concerns, especially when used concurrently with anthracyclines. Here we present an elderly patient with relapsed HER2+ breast cancer. Her presentation for relapsed disease was unusual for the physical finding as well as the history of trastuzumab-induced severe cardiotoxicity while requiring additional anti-HER2 therapy. She received neoadjuvant anti-HER2 treatment for stage III breast caner. Due to severe reduction of cardiac ejection fraction (EF), she only received five doses of adjuvant transtuzumab. Unfortunately her disease relapsed one year later with chest wall lesions and a persistent low EF. We treated the patient with lapatinib combined with capecitabine which resulted rapid resolution of her chest wall lesion. More importantly, the patient had one year of disease control without deterioration in her ejection fraction. We discussed the management of recurrent HER2+ breast cancer with chest wall disease and the choice of anti-HER2 therapy in patients with a history of transtuzumab-induced cardiac dysfunction.
Advancing mechanistic understanding and biomarker development in amyotrophic lateral sclerosis (2021)

Proteomics has delivered unique insights into the pathogenesis of ALS and advanced the goal of objective measurements of disease activity to improve therapeutic trials. Further developments in sensitivity and quantification are expected, with application to the presymptomatic phase of human disease offering the hope of prevention strategies.
ChemInform Abstract: Asymmetric Synthesis of (R)‐ and (S)‐Enantiomers of Novel Phenylalanine Homologues. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A novel range-verification method using ionoacoustic wave generated from spherical gold markers for particle-beam therapy: a simulation study (2019)

This study proposes a novel alternative range-verification method for proton beam with acoustic waves generated from spherical metal markers. When proton beam is incident on metal markers, most of the resulting pressure waves are confined in the markers because of the large difference in acoustic impedance between the metal and tissue. However, acoustic waves with frequency equal to marker's resonant frequency escape this confinement; the marker briefly acts as an acoustic transmitter. Herein, this phenomenon is exploited to measure the range of the proton beam. We test the proposed strategy in 3-D simulations, combining the dose calculations with modelling of acoustic-wave propagation. A spherical gold marker of 2.0 mm diameter was placed in water with a 60 MeV proton beam incident on it. We investigated the dependence of pressure waves on the width of beam pulse and marker position. At short beam pulse, specific high-frequency acoustic waves of 1.62 MHz originating from the marker were observed in wave simulations, whose amplitude correlated with the distance between the marker and Bragg peak. Results indicate that the Bragg peak position can be estimated by measuring the acoustic wave amplitudes from the marker, using a single detector properly designed for the resonance frequency.
Film Cooling Discharge Coefficient Measurments in a Turbulated Passage With Internal Cross Flow (2001)

Gas turbine blades utilize internal geometry such as turbulator ribs for improved cooling. In some designs it may be desirable to benefit from the internal cooling enhancement of ribs as well as external film cooling. An experimental study has been performed to investigate the effect of turbulator rib placement on film hole discharge coefficient. In the study a square passage having a hydraulic diameter of 1.27 cm is used to feed a single angled film jet. The film hole angle to the surface is 30° and the hole length-to-diameter ratio is 4. Turbulators were placed in one of three positions: upstream of film hole inlet, downstream of film hole inlet, and with the film hole inlet centered between turbulators. For each case 90° turbulators with a passage blockage of 15% and a pitch to height ratio of 10 were used. Tests were run varying film hole-to-cross flow orientation as 30°, 90°, and 180°, pressure ratio from 1.02 to 1.8, and channel cross flow velocity from Mach 0 to 0.3. Film hole flow is captured in a static plenum with no external cross flow. Experimental results of film discharge coefficients for the turbulated cases and for a baseline smooth passage are presented. Alignment of the film hole entry with respect to the turbulator is shown to have a substantial effect on the resulting discharge coefficients. Depending on the relative alignment and flow direction, discharge coefficients can be increased or decreased 5 to 20% from the non-turbulated case, and in the worst instance experience a decrease of as much as 50%.
Verifying Isolation Properties in the Presence of Middleboxes (2014)

Great progress has been made recently in verifying the correctness of router forwarding tables. However, these approaches do not work for networks containing middleboxes such as caches and firewalls whose forwarding behavior depends on previously observed traffic. We explore how to verify isolation properties in networks that include such "dynamic datapath" elements using model checking. Our work leverages recent advances in SMT solvers, and the main challenge lies in scaling the approach to handle large and complicated networks. While the straightforward application of model checking to this problem can only handle very small networks (if at all), our approach can verify simple realistic invariants on networks containing 30,000 middleboxes in a few minutes.