gebhart/patrepeval huggingface dataset:
A Role for αvβ3 Integrin During Implantation in the Rabbit Model1 (2003)

The study of implantation has been facilitated by the identification of specific biomarkers that are associated with uterine receptivity. The alpha(v)beta(3) integrin is a cell surface adhesion receptor, whose expression has been shown to be elevated in the endometrium at the time of implantation in both humans and other mammalian species; however, the distribution of alpha(v)beta(3) in the rabbit model is unknown. The rabbit has been shown to be an excellent model for the study of implantation. As an obligate ovulator, the timing of pregnancy can be precisely established, and embryonic attachment occurs through specialized trophoblast-endometrial structures known as trophoblastic knobs. In the present study, the expression of alpha(v)beta(3) integrin subunit in the rabbit uterus was examined by reverse transcription-polymerase chain reaction (RT-PCR), immunohistochemistry, and in situ hybridization. Expression of the alpha(v)beta(3) integrin was examined in Day 6.5 embryos, flushed from pregnant does. Immunofluorescence demonstrated strong immunostaining on the rabbit blastocyst (Day 6.5). RT-PCR analyses showed higher levels of mRNA for beta(3) subunit at the implantation site, with reduced expression in nonimplantation sites and in nonpregnant adult and immature endometrium. Immunohistochemistry demonstrated little, if any, beta(3) immunoreactivity on the endometrial epithelium. In contrast, in situ hybridization showed expression of the beta(3) integrin subunit mRNA in the uterine myometrium and on the trophoblast. To further determine the functional significance of alpha(v)beta(3) integrin expression during implantation, pregnant female rabbits that underwent ventral laparotomy on the morning of Day 6 received intrauterine injection of the following into the right uterine horn: 1) the monoclonal alpha(v)beta(3) neutralizing antibody (LM609), 2) arg-gly-asp (RGD) hexapeptides (GRGDSP), 3) non-RGD hexapeptides (GRGESP), and 4) IgG isotype matched control antibody. The left horn served as a control and received only saline injections. A significant reduction in the number of implantation sites was observed in the horns receiving anti-alpha(v)beta(3) antibody (P < 0.001) and the RGD peptides (P = 0.03). In the rabbit, the alpha(v)beta(3) integrin is present on the embryo and trophoblast and appears to be involved in early embryo-maternal interaction.
Gynecological Surgery and Low Back Pain in Older Women (2010)

Prior gynecological surgery and low-back pain were not significantly associated with side-to-side differences in the compliance of the sacroiliac joints or in significant changes in pelvic floor movement during a loading maneuver in a group of older women.
Generalized multiple description vector quantization (1999)

Packet-based data communication systems suffer from packet loss under high network traffic conditions. As a result, the receiver is often left with an incomplete description of the requested data. Multiple description source coding addresses the problem of minimizing the expected distortion caused by packet loss. An equivalent problem is that of source coding for data transmission over multiple channels where each channel has some probability of breaking down. Recent work in practical multiple description coding explores the design of multiple description scalar and vector quantizers for the case of two channels or packets. This paper presents a new practical algorithm, based on a ternary tree structure, for the design of both fixed- and variable-rate multiple description vector quantizers for an arbitrary number of channels. Experimental results achieved by codes designed with this algorithm show that they perform well under a wide range of packet loss scenarios.
Enhanced absorption in thin crystalline silicon films for solar cells by nanoimprint lithography (2012)

Two dimensional (2D) periodic photonic nanostructures, fabricated by nanoimprint lithography (NIL) and dry etching on the front surface of crystalline silicon (c-Si) layers, are investigated experimentally and theoretically in order to characterize their optical properties and demonstrate their relevance to photovoltaic (PV) applications. Nanoimprint lithography is performed on c-Si wafers and ultra-thin c-Si films with various thicknesses. A comparison with state-ofthe- art front side texturing with an antireflection coating is made. The 2D periodic photonic nanostructures result in an enhanced light absorption in the photoactive material. The results are validated through simulations based on Rigorous Coupled Wave Analysis (RCWA). The nanoimprinted substrates result in a similar absorption compared to the state-ofthe- art random pyramid texturing while consuming less than a micron of photoactive material. In contrast to the random pyramid texturing, the nanopatterning exhibits a robust performance for a wide range of incident angles up to 70&deg;. The light trapping mechanism we propose is based on the combination of a graded index effect and the diffraction of light inside the photoactive layer at high angles.
Pneumococcal Keratitis, Bacteremia, and Septic Arthritis in an Asplenic Patient (1996)

We report the case of a 66-year-old black woman who presented with concomitant acute infectious keratitis, bacteremia, and septic arthritis caused by Streptococcus pneumonia. The septic arthritis resolved rapidly with surgical drainage and intravenous antibiotics, but despite aggressive topical and intravenous antibiotic therapy for the infectious keratitis, the cornea perforated, the patient developed endophthalmitis, and the eye eventually was eviscerated. To the best of our knowledge this is the first reported case of this nature. This patient had undergone splenectomy > 50 years prior to developing these infections. Although the risk of serious infection in clinically significant bacteremia is greatest in the perioperative period after splenectomy, these patients are at increased risk of such events for a lifetime. Because encapsulated bacteria, especially Pneumococcus, pose the greatest risk of sepsis and infection in asplenic patients, pneumococcal vaccination of penicillin prophylaxis must always be considered in these patients. A careful and complete medical history and systemic evaluation remain a crucial element of the evaluation and management of serious infectious keratitis.
Multisensor Precise Positioning for Automated and Connected Vehicles (2020)

New technologies and services are being developed every day to support the evolution of automated vehicles (AVs). The ultimate goal is to provide safety features and driving automation systems to enable driverless operation resulting in more efficient transportation. A reliable navigation system relies on the information from both positioning and warning systems, and can even integrate both to provide a robust solution with high integrity. The Global Positioning System (GPS) is the first fully operational global navigation satellite system (GNSS) that provides all-weather worldwide coverage. An inertial navigation system (INS) is a navigation system that includes a navigation processor and an inertial measurement unit (IMU). The IMU consists typically of accelerometers to measure specific forces (acceleration) and gyroscopes to measure angular rotation rates. Odometry is the calculation of the change in position and the speed of an object using motion sensors.
Breathing Pattern Estimation Using Wearable Bioimpedance for Assessing COPD Severity (2022)

Breathing pattern has been shown to be different in chronic obstructive pulmonary disease (COPD) patients compared to healthy controls during rest and walking. In this study we evaluated respiratory parameters and the breathing variability of COPD patients as a function of their severity. Thoracic bioimpedance was acquired on 66 COPD patients during the performance of the six-minute walk test (6MWT), as well as 5 minutes before and after the test while the patients were seated, i.e. resting and recovery phases. The patients were classified by their level of airflow limitation into moderate and severe groups. We characterized the breathing patterns by evaluating common respiratory parameters using only wearable bioimpedance. Specifically, we computed the median and the coefficient of variation of the parameters during the three phases of the protocol, and evaluated the statistical differences between the two COPD severity groups. We observed significant differences between the COPD severity groups only during the sitting phases, whereas the behavior during the 6MWT was similar. Particularly, we observed an inverse relationship between breathing pattern variability and COPD severity, which may indicate that the most severely diseased patients had a more restricted breathing compared to the moderate patients.
HAND ASSISTED LAPAROSCOPIC TRAINING FOR POSTGRADUATE UROLOGISTS: THE ROLE OF MENTORING (2004)

Mentoring provides a useful adjunct to postgraduate urological training and the integration of laparoscopic techniques into the community based practice of urology.
Spectroelectrochemistry of potassium ethylxanthate, bis(ethylxanthato)nickel(ii) and tetraethylammonium tris(ethylxanthato)nickelate(ii)† (2001)

Electrochemical and chemical oxidation of S2COEt−, Ni(S2COEt)2, and [Ni(S2COEt)3]− have been studied by CV and in situ UV-VIS spectroscopy in acetonitrile. Cyclic voltammograms of S2COEt− and Ni(S2COEt)2 display one (0.00 V) and two (0.35 and 0.80 V) irreversible oxidation peaks, respectively, referenced to an Ag/Ag+ (0.10 M) electrode. However, the cyclic voltammogram of [Ni(S2COEt)3]− displays one reversible (−0.15 V) and two irreversible (0.35, 0.80 V) oxidation peaks, referenced to an Ag/Ag+ electrode. The low temperature EPR spectrum of the oxidatively electrolyzed solution of (NEt4)[Ni(S2COEt)3] indicates the presence of [NiIII(S2COEt)3], which disproportionates to Ni(S2COEt)2, and the dimer of the oxidized ethylxanthate ligand, (S2COEt)2 ((S2COEt)2 = C2H5OC(S)SS(S)COC2H5), with a second order rate law. The final products of constant potential electrolysis at the first oxidation peak potentials of S2COEt−, Ni(S2COEt)2, and [Ni(S2COEt)3]− are (S2COEt)2; Ni2+(sol) and (S2COEt)2; and Ni(S2COEt)2 and (S2COEt)2, respectively. The chemical oxidation of S2COEt− to (S2COEt)2, and [Ni(S2COEt)3]− to (S2COEt)2 and Ni(S2COEt)2 were also achieved with iodine. The oxidized ligand in the dimer form can be reduced to S2COEt− with CN− in solution.
Development and pharmacological validation of novel methods of B cell activation in rat whole blood (2014)

Two novel methods were developed to stimulate B cells in rat whole blood, that have the potential to be used to support drug discovery efforts in the therapeutic targeting of B cells. Furthermore, we pharmacologically validated these whole blood assays using highly selective inhibitors of BTK, SYK, and PI3Kδ, signaling kinases which are downstream of the B cell receptor.
Disposition of the major proteins in the isolated erythrocyte membrane. Proteolytic dissection (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDisposition of the major proteins in the isolated erythrocyte membrane. Proteolytic dissectionTheodore L. Steck, G. Fairbanks, and D. F. H. WallachCite this: Biochemistry 1971, 10, 13, 2617–2624Publication Date (Print):June 1, 1971Publication History Published online1 May 2002Published inissue 1 June 1971https://pubs.acs.org/doi/10.1021/bi00789a031https://doi.org/10.1021/bi00789a031research-articleACS PublicationsRequest reuse permissionsArticle Views404Altmetric-Citations226LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Deconvolution of differential OTF (dOTF) to measure high-resolution wavefront structure (2015)

Differential OTF uses two images taken with a telescope pupil modification between them to measure the complex field over most of the pupil. If the pupil modification involves a non-negligible region of the pupil, the dOTF field is blurred by convolution with the complex conjugate of the pupil field change. In some cases, the convolution kernel, or difference field, can cause significant blurring. We explore using deconvolution to recover a highresolution measurement of the complex pupil field. In particular, by assuming we know something about the area and nature of the difference field, we can construct a Wiener filter that increases the resolution of the complex pupil field estimate in the presence of noise. By introducing a controllable pupil modification, such as actuating a telescope primary mirror segment in piston-tip-tilt to make the measurement, we explain added features to the difference field which can be used to increase the signal-to-noise ratio for information in arbitrary ranges of spatial frequency. We will present theory and numerical simulations to discuss key features of the difference field which lead to its utility for deconvolution of dOTF measurements.
Is an anticancer immune response mandatory for therapeutic success (2008)

The question as to whether and to which extent immunosurveillance controls and shapes the development of human cancers has been the subject of recent reviews. One important question concerns the impact of conventional anticancer chemotherapy on the relationship between the tumor and the immune system. Therapy, which is applied during the escape phase, not only affects the tumor; it also modulates the relationship between the tumor and the immune system. Thus, chemotherapy can, by simply reducing the tumor mass (debulking), reduce its immunosuppressive properties. By enforcing the selection of chemotherapy resistant tumor cells and by inducing additional mutations (chemotherapy often involves mutagenic agents), therapy can induce the expression of new tumor antigens. Chemotherapy can cause immunogenic cancer cell stress or death and hence mediate some kind of cancer vaccination effect. Furthermore, chemotherapy can stimulate the immune system, either by a direct effect on immune effectors or regulatory mechanisms or indirectly, by causing lymphopenia followed by homeostatic proliferation of immune effectors that may be particularly active in the anti-cancer response. The combination of these effects may reset the relationship between the tumor and the immune system from the latest stage (escape) to a preceding state (elimination or equilibrium). Thus, we recently reported that oxaliplatinum, anthracyclines and X Rays specifically induce antitumor immune responses that result from immunogenic cancer cell death. This anti-cancer immune response then helps to eliminate residual cancer cells (that failed to be killed by chemotherapy) or maintains micrometastases in a stage of dormancy. We have investigated the molecular pathways involved in the immunogenicity of cell death (triggered by cytotoxic compounds) and delineated certain components dictating the cross-talk between dying tumor cells and dendritic cells. We have reported that the rapid exposure of calreticulin to the cell membrane (1), followed by the exodus of the nuclear high mobility group box1 protein (2) and other new molecules (3) all contributed to mobilize dendritic cells for T cell activation in tumor-bearing hosts. This work has several clinical implementations. First, the description of single nucleotide polymorphisms located in genes encoding immune functions and receptors involved in the immunogenicity of cell death may have impact on the success of some therapeutic regimen. Compensating genetic defects in the signaling pathways dictating the immunogenicity of cell death may be a key strategy to transform non responses into objective clinical benefit. Second, we will also discuss the rationale of clinical trials to evaluate and eventually increase the contribution of anti-tumor immune responses to the therapeutic management of neoplasia. This abstract was published in Cancer Immunity, a Cancer Research Institute journal that ceased publication in 2013 and is now provided online in association with Cancer Immunology Research.
249 EXPRESSION OF GROWTH-RELATED IMPRINTED GENES IN DECEASED NEWBORN AND SURVIVING CLONED PIGLETS (2005)

Different from cloned mice and cattle, which are often born with large offspring syndrome (LOS), pigs produced through nuclear transfer have not been found to be overly large compared to their age-matched controls. In our study, significant differences ( P &amp;lt; 0.05) were found in the body weight of both deceased newborn cloned piglets ( n = 9) (1.2 ± 0.8 vs. 2.1 ± 0.2 kg) and cloned pigs at one month of age ( n = 7) (6.1 ± 1.3 vs. 8.0 ± 0.8 kg), when compared to their controls ( n = 5 for each age group). Because imprinted genes are important regulators of fetal growth and are subject to reprogramming during nuclear transfer, we aimed to determine the expression levels of both growth-enhancing and growth-inhibiting imprinted genes in these cloned pigs by real time quantitative reverse transcription polymerase chain reaction (RT-PCR). These genes include: Igf2 and Peg3 (growth-promoting), and Igf2r and Grb10 (growth-inhibiting). Tissues from six major organs were collected from clones and controls of both age groups. SYBR Green I was utilized as a reporter for the PCR reactions and 18S ribosomal RNA was used as the internal reference for quantifying the relative expression level of all genes. With the exception of Igf2, the other three imprinted genes were found to have statistically different levels of expression in certain organs of both groups of pigs when compared to their age-matched controls. However, no strong correlation was found between the levels of gene expression and the low-body-weight phenotype of the cloned pigs. Contrary to the notion that nuclear transfer can reduce the variation in the resulting animals due to their identical genetic make-up, larger variances of gene expression were found in clones of both groups, indicating the randomness of the nuclear reprogramming process. For all four imprinted genes studied, the coefficient of variation (CV) decreased greatly from newborn to one month old in both clones and controls, suggesting a more stringent regulation on imprinted gene expression after birth.
SETDB1-Mediated Cell Fate Transition between 2C-Like and Pluripotent States (2020)

Known as a histone H3K9 methyltransferase, SETDB1 is essential for embryonic development and pluripotent inner cell mass (ICM) establishment. However, its function in pluripotency regulation remains elusive. In this study, we find that under the "ground state" of pluripotency with two inhibitors (2i) of the MEK and GSK3 pathways, Setdb1-knockout fails to induce trophectoderm (TE) differentiation as in serum/LIF (SL), indicating that TE fate restriction is not the direct target of SETDB1. In both conditions, Setdb1-knockout activates a group of genes targeted by SETDB1-mediated H3K9 methylation, including Dux. Notably, Dux is indispensable for the reactivation of 2C-like state genes upon Setdb1 deficiency, delineating the mechanistic role of SETDB1 in totipotency restriction. Furthermore, Setdb1-null ESCs maintain pluripotent marker (e.g., Nanog) expression in the 2i condition. This "ground state" Setdb1-null population undergoes rapid cell death by activating Ripk3 and, subsequently, RIPK1/RIPK3-dependent necroptosis. These results reveal the essential role of Setdb1 between totipotency and pluripotency transition.
Low frequency noise in GaN metal semiconductor and metal oxide semiconductor field effect transistors (2001)

The low frequency noise in GaN field effect transistors has been studied as function of drain and gate biases. The noise dependence on the gate bias points out to the bulk origin of the low frequency noise. The Hooge parameter is found to be around 2×10−3 to 3×10−3. Temperature dependence of the noise reveals a weak contribution of generation–recombination noise at elevated temperatures.
Pristane-Accelerated Autoimmune Disease in (SWR X NZB) F1 Mice Leads to Prominent Tubulointerstitial Inflammation and Human Lupus Nephritis-Like Fibrosis (2016)

Mouse models lupus nephritis (LN) have provided important insights into disease pathogenesis, although none have been able to recapitulate all features of the human disease. Using comprehensive longitudinal analyses, we characterized a novel accelerated mouse model of lupus using pristane treatment in SNF1 (SWR X NZB F1) lupus prone mice (pristane-SNF1 mice). Pristane treatment in SNF1 mice accelerated the onset and progression of proteinuria, autoantibody production, immune complex deposition and development of renal lesions. At week 14, the pristane-SNF1 model recapitulated kidney disease parameters and molecular signatures seen in spontaneous disease in 36 week-old SNF1 mice and in a traditional IFNα-accelerated NZB X NZW F1 (BWF1) model. Blood transcriptome analysis revealed interferon, plasma cell, neutrophil, T-cell and protein synthesis signatures in the pristane-SNF1 model, all known to be present in the human disease. The pristane-SNF1 model appears to be particularly useful for preclinical research, robustly exhibiting many characteristics reminiscent of human disease. These include i) a stronger upregulation of the cytosolic nucleic acid sensing pathway, which is thought to be key component of the pathogenesis of the human disease, and ii) more prominent kidney interstitial inflammation and fibrosis, which have been both associated with poor prognosis in human LN. To our knowledge, this is the only accelerated model of LN that exhibits a robust tubulointerstitial inflammatory and fibrosis response. Taken together our data show that the pristane-SNF1 model is a novel accelerated model of LN with key features similar to human disease.
Practical Synthesis of (2′R)-2′-Deoxy-2′-C-methyluridine by Highly Diastereoselective Homogeneous Hydrogenation (2010)

Diastereoselective hydrogenation of 2'-deoxy-2'-exo-methyleneuridine was carried out under homogeneous conditions using a low loading of a chiral Rh catalyst. This, coupled with improvements in the synthesis of the substrate, allowed the smooth pilot plant preparation of the title compound on >10 kg scale.