gebhart/patrepeval huggingface dataset:
Fludarabine and Melphalan Compared with Reduced Doses of Busulfan and Fludarabine Improve Transplantation Outcomes in Older Patients with Myelodysplastic Syndromes (2021)

Reduced-intensity conditioning (RIC) regimens developed to extend the use of allogeneic hematopoietic stem cell transplantation (HSCT) to older patients have resulted in encouraging outcomes. We aimed to compare the 2 most commonly used RIC regimens, i.v. fludarabine with busulfan (FluBu) and fludarabine with melphalan (FluMel), in patients with myelodysplastic syndrome (MDS). Through the Center for International Blood and Marrow Transplant Research (CIBMTR), we identified 1045 MDS patients age ≥60 years who underwent first HSCT with a matched related or matched (8/8) unrelated donor using an RIC regimen. The CIBMTR's definition of RIC was used: a regimen that incorporated an i.v. busulfan total dose ≤7.2 mg/kg or a low-dose melphalan total dose ≤150 mg/m<sup>2</sup>. The 2 groups, recipients of FluBu (n = 697) and recipients of FluMel (n = 448), were comparable in terms of disease- and transplantation-related characteristics except for the more frequent use of antithymocyte globulin or alemtuzumab in the FluBu group (39% versus 31%). The median age was 67 years in both groups. FluMel was associated with a reduced relapse incidence (RI) compared with FluBu, with a 1-year adjusted incidence of 26% versus 44% (P ≤ .0001). Transplantation-related mortality (TRM) was higher in the FluMel group (26% versus 16%; P ≤ .0001). Because the magnitude of improvement with FluMel in RI was greater than the improvement in TRM with FluBu, disease-free survival (DFS) was better at 1 year and beyond with FluMel compared with FluBu (48% versus 40% at 1 year [P = .02] and 35% versus 27% at 3 years [P = .01]). Overall survival was comparable in the 2 groups at 1 year (63% versus 61%; P = .4) but was significantly improved with FluMel compared with FluBu at 3 years (46% versus 39%; P = .03). Our results suggest that FluMel is associated with superior DFS compared with FluBu owing to reduced RI in older patients with MDS patients. © 2021 American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc.
Processes limiting the performance of InAs/GaSb superlattice mid-infrared PIN mesa photodiodes (2006)

In this study, we examine processes limiting the performance of 4 micron superlattice pin photodiodes for different temperature and mesa size regimes. We show that the performance of large mesa photodiodes at low temperature is most severely limited by a trap-assisted tunneling leakage current (x300), while small mesa sizes are additionally limited by perimeter leakage (x20). At room temperature, large mesa photodiodes are limited by the diffusion current, and small mesa photodiodes are further limited by the perimeter leakage (x100). To reduce or eliminate the impact of perimeter leakage, we have tried passivating the mesa sidewalls with SiN, an approach that was only minimally successful. We have also laid the groundwork for another approach to elimination of perimeter leakage currents, namely, elimination of the sidewalls altogether through planar processing techniques. Planar processing schemes require the deposition of a thick, wide bandgap semiconductor or "window layer" on top of the homojunction. We compare the performance of two otherwise identical InAs/GaSb superlattice homojunction detectors, except one with a GaSb window layer, and one without. We show that inclusion of the thick GaSb window layer does not degrade detector performance.
Mollaret meningitis. A report of three cases (1976)

Three cases of benign, recurrent meningitis of Mollaret demonstrated unusual aspects of this disease. Postpartum pituitary necrosis was an antecedent event in one case. A second case occurred in an otherwise healthy 82-year-old woman, and a third patient was thought to have Histoplasma meningitis. The pathophysiology of Mollaret meningitis remains an enigma, and the therapy consists of supportive care.
ChemInform Abstract: Growth, Corrosion, and Capacity of Copper Oxide Films Investigated by Pulse Techniques. (1987)

Abstract The potentiostatic formation of anodic copper oxides and their reduction are investigated by using a novel computer‐assisted pulse technique.
NT‐proBNP is increased in healthy pregnancies compared to non‐pregnant controls (2008)

Serum concentrations of the amino-terminal pro-B-type natriuretic peptide (NT-proBNP) may be used to monitor cardiac function during pregnancy but normal values are not established for this purpose. Therefore, we investigated NT-proBNP in normotensive healthy pregnancies compared to a non-pregnant control group. Serum NT-proBNP was measured in 94 normotensive, healthy pregnant women (32+/-6 years) every five weeks beginning from 12th gestational week (GW) in a longitudinal study and compared to a non-pregnant control group of 521 women (32+/-7 years). Pooled median serum NT-proBNP levels (25th; 75th percentile) were significantly higher in pregnant women compared to non-pregnant women (56 (33; 95) pg/ml vs. 38 (22; 62) pg/ml (p<0.001)). NT-proBNP increased during pregnancy to 73 (51; 124) pg/ml in the 11+6 to 15+6 GW (p<0.001). However, NT-proBNP levels from 23+0 GW towards term were comparable to non-pregnant controls. NT-proBNP is significantly elevated in healthy pregnancies until mid-pregnancy. As preeclampsia and gestational hypertension are associated with increased NT-proBNP, our results have to be considered in future diagnostic approaches using NT-proBNP for these pathologic conditions.
Lowest‐density MDS array codes for reliable Smart Meter networks (2015)

Abstract In this paper, we introduce a lowest‐density maximum‐distance separable (MDS) array code, which is applied to a Smart Meter network to introduce reliability. By treating the network as distributed storage with multiple sources, information can be exchanged between the nodes in the network allowing each node to store parity symbols relating to data from other nodes. A lowest‐density MDS array code is then applied to make the network robust against outages, ensuring low overhead and data transfers. We show the minimum amount of overhead required to be able to recover from r node erasures in an n node network and explicitly design an optimal array code with lowest density. In contrast to existing codes, this one has no restrictions on the number of nodes or erasures it can correct. Furthermore, we consider incomplete networks where all nodes are not connected to each other. This limits the exchange of data for purposes of redundancy, and we derive conditions on the minimum node degree that allow lowest‐density MDS codes to exist. We also present an explicit code design for incomplete networks that is capable of correcting two node failures. Copyright © 2015 John Wiley &amp; Sons, Ltd.
Web-Foot or Syndactylism in the Fowl (1969)

INTRODUCTION NORMAL chickens have small webs between toes 2 and 3, and 3 and 4, sufficient to permit the use of a punch for identification purposes with baby chicks. By contrast, pigeons and many other kinds of birds normally are devoid of web, and waterfowl typically have complete webbing. Partial webbing or syndactylism is normal in some of the Coraciiformes, such as kingfishers, in which toes 3 and 4 are joined closely. The purpose of this paper is to record our observations on spontaneous occurrences of increased web development and syndactylism in the fowl and to relate these to previous studies on the condition, both genetic and teratological. Not many poultrymen have ever seen the condition, and it is not specified as a characteristic of any breed, though varieties with heavily-feathered feet are reported to have a tendency to increased web or syndactyly between toes 3 and 4 (review by…
Supplementary Figure 3 from PI3K Inhibition Impairs BRCA1/2 Expression and Sensitizes BRCA-Proficient Triple-Negative Breast Cancer to PARP Inhibition (2023)

&lt;p&gt;PDF file - 301K, Combined PIK3CA siRNA and PARP suppression in TNBC cell lines&lt;/p&gt;
MECONIUM ASPIRATION SYNDROME AND MECHANISMS OF COMPLEMENT ACTIVATION (2008)

Background Meconium aspiration syndrome has a complex pathophysiology. Meconium is a potent activator of the complement system both in vitro and in vivo associated with an inflammatory response. Meconium activates complement via the alternative pathway. Recent studies suggest the involvement of different complement pathways. Objective The aim of the study was to investigate whether meconium activates complement via several pathways. Methods Cord whole blood from six healthy donors, anticoagulated with lepirudin was preincubated with C1-inhibitor in different concentrations before adding meconium and incubating for 30 minutes. Early complement activation products were measured. Mannose-binding lectin (MBL) sufficient serum was collected from five healthy donors and used in a final dilution of 1 : 2. Serum was preincubated with anti-MBL before adding meconium and incubated for 30 minutes. The terminal sC5b-9 complex (TCC) and C4d was measured. Results Meconium-induced complement activation (TCC) was dose-dependently reduced by C1-inhibitor. Meconium-induced formation of the alternative pathway convertase C3bBbP, and C4d (classic and lectin pathway) was dose-dependently reduced by C1-inhibitor. The anti-MBL antibody significantly reduced meconium-induced formation of C4d more than 63% and TCC with 27% in MBL sufficient serum. Discussion The fact that anti-MBL reduced meconium-induced complement activation and C4d formation in lectin pathway sufficient serum suggests that meconium primarily activates both the alternative pathway and lectin pathway, and that part of the alternative pathway activation may be an amplification of lectin pathway activation. Conclusion Meconium activates complement via the lectin pathway and alternative pathway. Part of the alternative pathway activation is probably an amplification of lectin pathway activation.
Scytalols A, B, C, and D and Other Modulators of Melanin Biosynthesis from Scytalidium sp. 36-93. (1998)

From submerged cultures of Scytalidium sp. 36-93, ten metabolites were isolated due to their effects on dihydroxynaphthalene (DHN) or DOPA melanin biosynthesis. Four of the compounds, scytalols A (1a), B (1b), C (2) and D (3), are new secondary metabolites, the structures of which were determined by spectroscopy, while the other compounds are known. Scytalols A (1a) and D (3) are selective inhibitors of DHN melanin biosynthesis and exhibit no antifungal or cytotoxic activities. Nectriapyrone, 6-methoxymellein and 4-chloro-6-methoxymellein stimulated the formation of DOPA melanin in B16-F1 melanoma cells in the absence of melanin-stimulating hormone.
Figure S1 from Theranostic Radiolabeled Anti-CD20 sdAb for Targeted Radionuclide Therapy of Non-Hodgkin Lymphoma (2023)

&lt;p&gt;Human CD20 expression on hCD20pos B16 cells was analyzed by flow cytometry. A) 2 x 105 Daudi cells or (B) hCD20pos B16 cells were incubated with 10 µg of Rituximab for 1h at 4{degree sign}C. After washing the cells, Rituximab binding was detected by adding 1 µg of human anti-IgG1 PE mAb (clone IS11-12E4.23.20, Miltenyi Biotec) for 30 min at 4{degree sign}C. After washing, mean fluorescence intensity (MFI) was measured using a FACS Canto Flow Cytometer (BD) and analyzed with Flow Jo 7 software (Tree Star Inc., Ashland, Oregon, USA). Background controls included: unstained Daudi and hCD20pos B16 cells, and Daudi and hCD20pos B16 cells incubated with anti-HER2 Trastuzumab mAb (isotype control) and further processed as described above. C) hCD20-expression was similar for both Daudi and hCD20pos B16 cells.&lt;/p&gt;
An NLFSR-Based Stream Cipher (2006)

We propose a hardware oriented 80-bit-key binary additive stream cipher. The keystream generator consists of ten nonlinear feedback shift registers whose output sequences are combined by a Boolean function of algebraic degree four. The design size of the keystream generator is about 2200 GE. In 130nm CMOS-technology, a throughput of more than 1 Gbps can be achieved. The length of the initial value used for resynchronization can be any multiple of eight between zero and eighty. The maximum amount of keystream that can be used between two resynchronization steps is 2/sup 68/ bits. A parallel implementation of the stream cipher produces one byte of keystream per clock cycle.
Achieving low magnetic flux density and low electric field intensity for an inductive wireless power transfer system (2017)

In most loosely coupled inductive wireless power transfer systems, the air-gap magnetic flux density between coils is still far above safety limit, which is a potential threat to human beings and animals. In addition, less attention is paid to the air-gap electric field intensity, which increases significantly as the operating frequency increases. In this paper, a multi-kW inductive wireless power transfer system general design methodology that can inherently achieve low air-gap center plane magnetic flux density and electric field intensity is proposed. The effects of coil radius, number of turns, inter-turn distance and operating frequency are investigated. Proposed methodology is evaluated with a 3 kW, 30 cm distance wireless power transfer design example by FEA and experiment tests. Power scaling law within air-gap center plane magnetic field and electric field safety limits is developed.
On clustering heterogeneous social media objects with outlier links (2012)

The clustering of social media objects provides intrinsic understanding of the similarity relationships between documents, images, and their contextual sources. Both content and link structure provide important cues for an effective clustering algorithm of the underlying objects. While link information provides useful hints for improving the clustering process, it also contains a significant amount of noisy information. Therefore, a robust clustering algorithm is required to reduce the impact of noisy links. In order to address the aforementioned problems, we propose heterogeneous random fields to model the structure and content of social media networks. We design a probability measure on the social media networks which output a configuration of clusters that are consistent with both content and link structure. Furthermore, noisy links can also be detected, and their impact on the clustering algorithm can be significantly reduced. We conduct experiments on a real social media network and show the advantage of the method over other state-of-the-art algorithms.
Bioinspired Environmental Coordination in Spatial Computing Systems (2008)

Spatial computing systems are characterized by the extended physical environment in which they exist and function. Often this environment can be manipulated in various ways by the computing agents. We argue that it is important to consider the potential use of the environment for coordination and indirect communication in such systems. For inherently spatial problems, it can be more effective to store spatially relevant information in the environment rather than in the computing devices, as in the case of mobile agents or long-term physical structures. In scientific settings, considering the role of the environment can illuminate mechanisms or processes that might otherwise be overlooked; in engineering problems, it can provide simpler and more effective solutions than could be achieved by relying on the computing devices alone. We give as examples problems related to foraging, collective construction, simultaneous localization and mapping, object tracking, and behaviors of living tissues. We suggest in closing a classification scheme for capabilities of environmental elements, relevant to the design of physically embodied spatial computing systems.
Determination of Total N-Nitroso Compounds by Chemical Denitrosation Using CuCl (2005)

A method for the determination of total N-nitroso compounds (NOC) by chemical denitrosation and subsequent chemiluminescence detection of evolved NO is described. Denitrosation was accomplished with CuCl in HCl at 70 degrees C. The detection limit for N-nitrosoproline (NPRO) was 1 pmol. NO formation from NPRO was linear (R(2) = 0.999) from 4 pmol to 2 nmol. Among the possible interfering compounds tested, only S-nitroso compounds contribute any significant interference. This method had several advantages over other similar methods: (1) A commercially available one-piece reaction vessel and a NO analyzer with software were used. (2) NO release occurred rapidly and was easily measured and quantified. (3) Compared to HBr or HI, CuCl was more convenient to work with and safe. (4) CuCl was suitable for samples in aqueous and most organic solvents. The application of this method to food, personal care products, and human body fluids demonstrates its utility.
Adjustable speed drives transportation industry needs part I: automotive (2003)

Adjustable speed drives for applications in the transportation industry are significantly different and face economic and cost pressures exceeding those of other industries. This and a companion paper are a summary of the present status of adjustable speed drives in the automotive, utility, and aerospace industries, including relevant topics of research and development. Specific topics in part I include the application of ASD's in hybrid electric vehicles and advanced technology vehicles that rely on x-by-wire technologies. In part II special treatment is given to hybrid vehicle R&D topics and aerospace propulsion needs. Particular emphasis has been given to automotive industry needs, specifically those related to environmental and performance, and how these constraints impact installation costs.
Phorbol Ester Inhibition of Ovarian and Testicular Steroidogenesis in Vitro (1984)

No AccessJournal of Urology1 Nov 1984Phorbol Ester Inhibition of Ovarian and Testicular Steroidogenesis in Vitro T.H. Welsh, P.B.C. Jones, and A.J.W. Hsueh T.H. WelshT.H. Welsh More articles by this author , P.B.C. JonesP.B.C. Jones More articles by this author , and A.J.W. HsuehA.J.W. Hsueh More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)50012-9AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Phorbol Ester Inhibition of Ovarian and Testicular Steroidogenesis in Vitro." The Journal of Urology, 132(5), pp. 1062–1063 © 1984 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 132 Issue 5 November 1984 Page: 1062-1063 Advertisement Copyright & Permissions© 1984 by The American Urological Association Education and Research, Inc.Metrics Author Information T.H. Welsh More articles by this author P.B.C. Jones More articles by this author A.J.W. Hsueh More articles by this author Expand All Advertisement PDF downloadLoading ...
Kinetics of Dimerization and Interactions of p13suc1 with Cyclin-Dependent Kinases (1998)

The impact of p13suc1 on the conformation and regulation of cyclin-dependent kinases (cdks) and cyclins was investigated by spectroscopic and rapid kinetic approaches. In the absence of phosphorylation on cdks, p13suc1 formed stable complexes, mainly stabilized by hydrophobic interactions, specifically with cdk2 and cdc2. The presence of cyclin A, associated with cdk2 or cdc2, increased the stability of the interaction between cdk2 and p13suc1 by a factor of 2. However, cyclin A did not modify the association rate of p13suc1 to cdk2, but the dissociation rate, which was decreased 3-fold. Moreover, binding of p13suc1 to cdk2 resulted in a 2-fold decrease in the release of nucleotide from cdk2, indicating that p13suc1 induces a marked change in the structure of the nucleotide binding site of cdks. On the basis of the structure of cdk2/CksHs1 complex and on our kinetic results, we propose that the binding of Cks proteins to C-lobe of cdk2 is stabilized by the presence of cyclin A and that it may modify the orientation of the loop carrying residues 14 and 15 and their consequent access for dephosphorylation by cdc25 phosphatases. Finally, we have shown that dimerization of p13suc1 in the presence of zinc abolishes its interaction with cdks, which suggests that the binding of p13suc1 to cdk2 or cdk2/cyclin A may be regulated by dimerization of p13suc1 in vivo.
A Naive Technique Correcting Time-Series Data for Recognition Applications (2009)

Wireless sensor data collected under real world conditions can contain a variety of errors and inconsistencies that can affect pattern recognition algorithms. We describea nainodotve method for correcting wireless sensor data collectedvia non-real-time platforms and visualize the results usingwireless accelerometer data.
β-Amino Amides from β-Lactams: Application to the Formal Synthesis of a Peptide-Deformylase Inhibitor (2006)

A facile and a practical synthesis of peptide-deformylase inhibitor 1 is described using an acid-catalyzed aminolysis of β-lactam 12 with pyrrolidine 6 as the key transformation. In addition, simplified conditions for the conversion of a β-hydroxy acid to a β-lactam are reported.
Molecular Imaging of Cardiovascular Disease (2007)

olecular imaging aims at sensing specific molecular targets, fundamental biological processes, and certain cell types in living subjects. An integrative discipline rooted in the biological, chemical, and imaging sciences, molecular imaging has broad applications in biology and drug discovery 1-5 and increasingly within cardiovascular disease. 6 -12 Before discussing key factors spurring the growth of this field, we first briefly review 2 essential components of this technology: imaging agents and imaging hardware.
Obesity and Type 2 Diabetes Mellitus (2001)

Many factors modify the association between obesity and type 2 diabetes. Longer duration of obesity increases risk. Body fat distribution is a risk factor for diabetes, and in women particularly, contributes independently to risk. Physical activity can reduce the risk of diabetes via obesity, but can also work independently. People with a positive family history of diabetes achieve the same risk as less susceptible individuals at lower levels of obesity. Differences between ethnic groups in the relationship between obesity and diabetes reflect differences in modifying risk factors including genotype. Mechanisms linking obesity and diabetes are unknown, but the ‘Thrifty genotype’ theory, whereby obesity and diabetes are both consequences of insulin resistance and hyperinsulinaemia, has been used to explain high rates of both, although new evidence suggests insulin resistance may limit weight gain. Resistance to the action of leptin may also be a factor in both obesity and glucose intolerance.
Framework for efficient and flexible scheduling of flash memory operations (2017)

Flash memory-based storages are used in a wide range of systems from small mobile devices to large-scale system servers. The performance demand from applications and the technology of flash memory vary widely from one system to another, making it difficult to design a universal flash memory scheduler for all systems. In this paper, we present a framework for efficient and flexible flash memory scheduling and compare a software scheduler based on the framework against an optimized hardware scheduler. The throughput of the software scheduler achieves more than 97% of that of the hardware scheduler across workloads we consider. We further highlight the extensibility of the framework with a case study on fair queueing scheduling.