gebhart/patrepeval huggingface dataset:
Safety and Antitumour Activity of ODM-201 (BAY-1841788) in Castration-resistant, CYP17 Inhibitor-naïve Prostate Cancer: Results from Extended Follow-up of the ARADES Trial (2017)

Extended ODM-201 therapy was well tolerated, with beneficial antitumour activity in men with advanced prostate cancer, indicating that ODM-201 may represent a new active treatment for men with CRPC. This extension trial is registered at ClinicalTrials.gov (www.clinicaltrials.gov) under identification number NCT01429064.
To schedule or not to schedule: when no-scheduling can beat the\n best-known flow scheduling algorithm in datacenter networks (2020)

Conventional wisdom for minimizing the average flow completion time (AFCT) in\nthe datacenter network (DCN), where flow sizes are highly variable, would\nsuggest scheduling every individual flow. However, we show that considering\nscheduling delay (including scheduler's computational and communication\ndelays), serving most of the flows without any scheduling and only in\nfirst-come-first-served (FCFS) manner significantly improves their performance\neven when it is compared to the shortest remaining processing time (SRPT)-known\nas optimum algorithm when scheduling delay is zero. To do so, we only require\nto have two coarse classes of flows categorized based on flows' sizes\n(1st-class including flows smaller than a threshold, H, and 2nd-class including\nothers) and serve 1st-class flows always before serving 2nd-class ones. To show\nthat, we take SRPT scheduling algorithm accompanied by the global knowledge of\nflows, formulate impact of scheduling delay on its performance, and prove that\nfor any flow size distribution and network load (&lt;1), there is always a\nthreshold, H, which guarantees 1st-class flows achieve lower AFCT under FCFS\ncompared to SRPT. Our numerically calculated results and extensive flow-level\nsimulations show that on average, more than 90% of flows could be in 1st-class\nand consequently do not require any scheduling.\n
Twist2, a novel ADD1/SREBP1c interacting protein, represses the transcriptional activity of ADD1/SREBP1c (2003)

Adipocyte determination and differentiation dependent factor 1 (ADD1)/sterol regulatory element binding protein isoform (SREBP1c) is a key transcription factor in fatty acid metabolism and insulin- dependent gene expression. Although its transcriptional and post-translational regulation has been extensively studied, its regulation by interacting proteins is not well understood. To identify cellular proteins that associate with ADD1/SREBP1c, we employed the yeast two-hybrid system with an adipocyte cDNA library. Using the N-terminal domain of ADD1/SREBP1c as bait, we identified Twist2 (also known as Dermo-1), a basic helix-loop-helix (bHLH) protein, as a novel ADD1/SREBP1c interacting protein. Over-expression of Twist2 strongly repressed the transcriptional activity of ADD1/SREBP1c, primarily by reducing its binding to target sequences. Inhibition of histone deacetylase (HDAC) activity with HDAC inhibitors relieved this repression. Our data suggest that physical interaction between Twist2 and ADD1/SREBP1c attenuates transcriptional activation by ADD1/SREBP1c by inhibiting its binding to DNA, and that this inhibition is at least partly dependent on chromatin modification by HDACs.
Influence of Shrinkage Mismatch between Copper and Ceramics on Dimensional Control of the Multilayer Ceramic Circuit Board (1992)

The shrinking behavior of Cu/ceramic circuit boards as it applies to controlling dimensional tolerances was studied. This report includes the shrinking behavior of ceramics and copper and of the Cu/ceramic interface. It also includes the relationship between the shrinkage of the Cu/ceramic circuit board during firing and the copper content of the laminated body (which is decided before firing). Results show that the mismatch in the onset of the components' sintering temperatures affects the microstructure of the Cu/ceramic interface. The total shrinkage mismatch causes compression stress in copper wiring. The firing shrinkage of the circuit board depends on its copper content and, as copper content increases, its shrinkage approaches that of copper paste.
Panretinal Photocoagulation vs Intravitreous Ranibizumab for Proliferative Diabetic Retinopathy (2015)

clinicaltrials.gov Identifier: NCT01489189.
Hhal andHpall DNA methyltransferases bind DNA mismatches, methylate uracil and block DNA repair (1995)

The hydrolytic deamination of 5-methylcytosine (5-mC) to thymine (T) is believed to be responsible for the high mutability of the CpG dinucleotide in DNA. We have shown a possible alternate mechanism for mutagenesis at CpG in which HpaII DNA-(cytosine-5) methyltransferase (M.HpaII) can enzymatically deaminate cytosine (C) to uracil (U) in DNA [Shen, J.-C., Rideout, W.M., III and Jones, P.A., Cell, 71, 1073-1080, (1992)]. Both the hydrolytic deamination of 5-mC and enzymatic deamination of C create premutagenic DNA mismatches (G:U and G:T) with the guanine (G) originally paired to the normal C. Surprisingly, we found that DNA-(cytosine-5) methyltransferases have higher affinities for these DNA mismatches than for their normal G:C targets and are capable of transferring a methyl group to the 5-position of U, creating T at low efficiencies. This binding by methyltransferase to mismatches at the recognition site prevented repair of G:U mismatches by uracil DNA glycosylase in vitro.
The MsK family of alfalfa protein kinase genes encodes homologues of shaggy/glycogen synthase kinase‐3 and shows differential expression patterns in plant organs and development (1993)

This paper reports on the isolation of a novel class of plant serine/threonine protein kinase genes, MsK-1, MsK-2 and MsK-3. They belong to the superfamily of cdc2-like genes, but show highest identity to the Drosophila shaggy and rat GSK-3 proteins (65-70%). All of these kinases share a highly conserved catalytic protein kinase domain. Different amino-terminal extensions distinguish the different proteins. The different plant kinases do not originate from differential processing of the same gene as is found for shaggy, but are encoded by different members of a gene family. Similarly to the shaggy kinases, the plant kinases show different organ-specific and stage-specific developmental expression patterns. Since the shaggy kinases play an important role in intercellular communication in Drosophila development, the MsK kinases are expected to perform a similar function in plants.
Light and Water Drops (2011)

Water drops are present throughout our daily lives. Microscopic droplets create fog and mist, and large drops fall as rain. Because of their shape and refractive properties, water drops exhibit a wide variety of visual effects. If not directly illuminated by a light source, they are difficult to see. But if they are directly illuminated, they can become the brightest objects in the environment. This thesis has two main components. First, we will show how to create two-and three-dimensional displays using water drops and a projector. Water drops act as tiny spherical lenses, refracting light into a wide angle. To a person viewing an illuminated drop, it will appear that the drop is the same color as the incident light ray. Using a valve assembly, we will fill a volume with non-occluding water drops. At any instant in time, no ray from the projector will intersect with two drops. Using a camera, we will detect the drops locations, then illuminate them with the projector. The final result is a programmable, dynamic, and three-dimensional display. Second, we will show how to reduce the effect of water drops in videos via spatio-temporal frequency analysis, and in real life, by using a projector to illuminate everything except the drops. To remove rain (and snow) from videos, we will use a streak model in frequency space to find the frequencies corresponding to rain and snow in the video. These frequencies can then be suppressed to reduce the effect of rain and snow. We will also suppress the visual effect of water drops by selectively “missing” them by not illuminating them with a projector. In light rain, this can be performed by tracking individual drops. This kind of drop-avoiding light source could be used for many nighttime applications, such as car headlights.
Simplified Electrophysiologically Directed Catheter Ablation of Recurrent Common Atrial Flutter (1997)

Background Despite verification of bidirectional conduction block after radiofrequency (RF) catheter ablation in the inferior vena cava (IVC)–tricuspid annulus (TA) isthmus, recurrence of common atrial flutter is relatively common. Although complete linear reablation is usually performed, we evaluated a simplified electrophysiological strategy selectively targeting recovered conducting isthmus tissue. Methods and Results Twenty-one patients (18 men and 3 women, age, 54±10 years) with a recurrence of typical atrial flutter 6±7 months after an apparently successful catheter ablation in the IVC-TA isthmus prospectively underwent electrophysiologically targeted reablation during flutter. Sites with narrow electrograms or fractionated electrograms interposed between adjacent sites with double potentials considered to represent gaps were ablated without movement of the catheter. Mapping showed that 18 of 21 patients had a single gap. Successful ablation required a single application in 14 patients and, in the group as a whole, a median of one application (mean, 2±2; range, 1 to 11) with resultant bidirectional block in 13 of 16. A single narrow electrogram (duration, 48±6 ms; amplitude, 0.1±0.05 mV) was noted at the successful site in 11, whereas a fractionated electrogram (97±32 ms, 0.05±0.04 mV, P &lt;.05) was noted in 9. There were four additional recurrences during a follow-up at 7±5 months; three were similarly ablated with a median of one pulse. Conclusions Transmural ablation lesions in the isthmus can be recognized during flutter by double potentials separated by an isoelectric interval. Postablation recurrent flutter is usually due to a single discrete recovered gap; this is represented by a single or a fractionated potential spanning the isoelectric interval of adjacent double potentials, which can be selectively targeted to minimize repeat ablation.
Perceptive spaces for performance and entertainment untethered interaction using computer vision and audition (1997)

Bulky head-mounted displays, data gloves, and severely limited movement have become synonymous with virtual environments. This is unfortunate, since virtual environments have such great potential in applications such as entertainment, animation by example, design interface, information browsing, and even expressive performance. In this article, we describe an approach to unencumbered natural interfaces called Perceptive Spaces. The spaces are unencumbered because they utilize passive sensors that do not require special clothing and large format displays that do not isolate the users from their environment. The spaces are natural because the open environment facilitates active participation. Several applications illustrate the expressive power of this approach, as well as the challenges associated with designing these interfaces.
Cancer and Their therapeutics (2016)

Cancer is still the leading cause of death by disease.Based on the GLOBOCAN series of the International Agency for Research on Cancer, the cancer-related deaths can reach 8 million in a single year.In year 2012, over 14 million new cases were reported.
Ca2+‐Ionen als Cofaktoren für ein neuartiges RNA‐spaltendes Desoxyribozym (1996)

Bei In‐vitro‐Selektionsexperimenten wurde ein unerwartetes, aber nichtsdestoweniger interessantes Resultat erhalten. Ein RNA‐spaltendes DNA‐Enzym, das in Gegenwart von Mg 2+ selektiert worden war, wies mit Ca 2+ als Cofaktor eine wesentlich höhere Effizienz auf. Dies ist wegen der geringeren hydrolytischen Wirksamkeit von Ca 2+ um so überraschender.
Protumoral effect of macrophage through Axl activation on mucoepidermoid carcinoma (2014)

TAMs play a protumoral role in MEC via activation of the Axl signaling pathway, up-regulating MMPs expression, and increasing invasion/migration ability.
Quantitative phase imaging of action potentials in mammalian cell culture (Conference Presentation) (2019)

Movements of the cell membrane accompanying action potentials have been detected by various methods, including reflection of a laser beam, atomic force microscopy and even bright-field microscopy. However, imaging of the entire cell dynamics during action potential has not been achieved, and the mechanism behind this phenomenon is still actively debated. Here we report full-field interferometric imaging of cellular movements during action potential by simultaneous quantitative phase microscopy (QPM) and multi-electrode array (MEA) recordings. Using spike-triggered averaging of the movies synchronized to electrical recording, we demonstrate deformations of up to 3 nm (0.9 mrad) during the action potential in spiking HEK-293 cells, with a rise time of 4 ms. The time course of the optically-recorded action potential is very similar to intracellular potential recorded with a whole-cell patch clamp, while the time derivative of the rising edge of the optical spike matches the timing and duration of the extracellular electrical recording on MEA. In some cells, phase increases at the center and decreases along the cell boundaries, while in others it increases on one side and decreases on the other. These findings suggest that optical phase changes during an action potential are due to cellular deformation, likely associated with changes in the membrane tension, rather than refractive index change due to ion influx or cell swelling. High-speed QPM may enable all-optical, label-free, full-field imaging of electrical activity in mammalian cells.
Transcriptomic Responses of Cancerous and Noncancerous Human Colon Cells to Sulforaphane and Selenium (2014)

Diets enriched with bioactive food components trigger molecular changes in cells that may contribute to either health-promoting or adverse effects. Recent technological advances in high-throughput data generation allow for observing systems-wide molecular responses to cellular perturbations with nontoxic and dietary-relevant doses while considering the intrinsic differences between cancerous and noncancerous cells. In this chemical profile, we compared molecular responses of the colon cancer cell line HT29 and a noncancerous colon epithelial cell line (HCEC) to two widely encountered food components, sulforaphane and selenium. We conducted this comparison by generating new transcriptome data by microarray gene-expression profiling, analyzing them statistically on the single gene, network, and functional pathway levels, and integrating them with protein expression data. Sulforaphane and selenium, at doses that did not inhibit the growth of the tested cells, induced or repressed the transcription of a limited number of genes in a manner distinctly dependent on the chemical and the cell type. The genes that most strongly responded in cancer cells were observed after treatment with sulforaphane and were members of the aldo-keto reductase (AKR) superfamily. These genes were in high agreement in terms of fold change with their corresponding proteins (correlation coefficient r(2) = 0.98, p = 0.01). Conversely, selenium had little influence on the cancer cells. In contrast, in noncancerous cells, selenium induced numerous genes involved in apoptotic, angiogenic, or tumor proliferation pathways, whereas the influence of sulforaphane was very limited. These findings contribute to defining the significance of cell type in interpreting human cellular transcriptome-level responses to exposures to natural components of the diet.
Incidence rate ratios (IRR) and 95% confidence intervals (95% CI) from unadjusted and adjusted Poisson regression models using person-year and hours walked as denominator stratified for gender, age, fall history and habitual walking speed based on one year observation time. (2015)

&lt;p&gt;* Gender-stratified model adjusted for age, age-stratified model adjusted for gender, fall history- and walking speed-stratified model adjusted for age and gender&lt;/p&gt;&lt;p&gt;&lt;sup&gt;#&lt;/sup&gt; Reference group&lt;/p&gt;&lt;p&gt;&lt;sup&gt;§&lt;/sup&gt; Missing values for walking speed (n = 58)&lt;/p&gt;&lt;p&gt;Incidence rate ratios (IRR) and 95% confidence intervals (95% CI) from unadjusted and adjusted Poisson regression models using person-year and hours walked as denominator stratified for gender, age, fall history and habitual walking speed based on one year observation time.&lt;/p&gt;
ChemInform Abstract: OBSERVATIONS ON THE THERMAL DECOMPOSITION OF SOME URANIUM(IV) TETRAALKYLS (1974)

Abstract Die thermisch instabilen Produkte der Reaktion von Urantetrachlorid (I) mit den Lithiumorganylen (II) scheinen Urantetraalkyle (III) zu sein, die in ätherischen oder Kohlenwasserstoff‐Lösungsmitteln bei Raumtemperatur schnell zerfallen.
50 nm lines patterned into silicon using water developable chitosan bioresist and electron beam lithography (2017)

30 mai - 2 juin 2017
Controlled trials of very high dose folic acid, vitamins B12 and B6, intravenous folinic acid and serine for treatment of hyperhomocysteinemia in ESRD. (2004)

In our studies high dose oral folic acid, intravenous folinic acid, vitamins B6 and B12 and oral serine were ineffective at lowering tHcy in patients on hemodialysis when given folic acid, folinic acid serine or B vitamins in addition to routine folic acid and B vitamin supplements.
Cascode switching modeling and improvement in flyback converter for LED lighting applications (2018)

Modeling of the cascode switching structure used in Flyback converter for achieving fast startup in the deeply dimmed phase-cut LED driver is presented in this paper. The cascode structure's inherent instability and oscillation issue is modeled and analyzed quantitatively. Three solutions are proposed to stabilize the structure and suppress the unstable voltage oscillation. Solutions are studied using the proposed model for design robustness. And this model can be further applied to the popular new high voltage (for example 650V) cascode GaN FET technology. Experimental results of a 20W phase-cut dimmable LED driver are demonstrated to verify the proposed modeling method and solutions.
Orthorhombic MoO3 Nanofibers as Cathode Materials for Lithium Batteries (2013)

We report the structural and electrochemical properties of MoO 3 nanofibers synthesized by hydrothermal reaction from acidified ammonium heptamolybdate tetrahydrate precursor. Structural analysis shows that MoO 3 nanofibers 50-80 nm in diameter and a several micrometers in length are grown in the orthorhombic system ( Pbnm S.G.). The composition MoO 2.9975 was determined by Rietveld refinement and magnetic susceptibility measurements. The electrochemical performance of Li//MoO 3 cells with nanofibers deliver a better discharge capacity after 40 cycles than MoO 3 bulk.
Characterization and partial purification of two pre‐tRNA 5′‐processing activities from Daucus carrota (carrot) suspension cells (1995)

Two distinct RNase P-like activities which cleave leader sequences from pre-tRNA molecules to give mature 5' ends have been identified in carrot suspension-culture cells. An Escherichia coli pre-tRNA(Phe) and a tobacco pre-tRNA(Tyr) were transcribed in vitro then used as substrates for processing reactions in a cell-free extract. The pre-tRNA(Tyr) transcript was used to establish optimal salt and divalent cation requirements for processing. Kinetic experiments were then carried out on both substrates to determine if 5' and 3' processing were ordered. Primer extension analysis of processing intermediates and stable products verified that an ammonium sulfate fraction of the extract was indeed capable of accurately processing the 5' ends of both pre-tRNAs. Subsequent fractionation of the 5' end-processing activity by chromatography on phosphocellulose revealed two distinct activities, eluting at 0.1 and 0.5 M KCI, when assayed with the tobacco pre-tRNA(Tyr) substrate. When the same fractions were assayed with the E. coli pre-tRNA(Phe), only the 0.1 M KCI fraction exhibited activity. Both of the active fraction display sensitivity to micrococcal nuclease (MN) and proteinase K indicating each is a ribonucleoprotein, a result not seen with other plant RNase Ps. Subsequent FPLC fractionation of the two activities using Mono Q and Mono S columns demonstrated that the two activities could be further distinguished on the basis of their chromatographic behavior.
BCX-4208 (RO5092888), a Purine Nucleoside Phosphorylase (PNP) Inhibitor, Is a Novel, Potent Orally Active Anti-T-Cell and B-Cell Agent. (2008)

Abstract The profound suppression of T-cell immunity seen in patients with an inherited PNP deficiency supports the potential application of inhibitors of this purine salvage enzyme in the therapy of T-cell malignancies and T-cell mediated autoimmune diseases. About thirty percent of PNP deficient patients also show evidence of B-cell dysfunction. BCX-4208 is a novel potent transition state analog inhibitor of PNP (IC50 ~ 0.0005 μM) and in the presence of 10 μM deoxyguanosine (dGuo), inhibits human lymphocyte proliferation induced by MLR, IL-2 or Con-A with IC50s of 0.159, 0.26 and 0.73 μM, respectively. The IC50 for dGuo in the same assays in the presence of 1 μM BCX-4208 ranges from 1–3 μM. Neither BCX-4208 alone nor dGuo alone inhibits proliferation of lymphocytes. In the presence of PNP inhibitor, dGuo is converted to dGMP and then to dGTP. Accumulation of dGTP results in the alteration of deoxynucleotide (dNTP) pools, causing death of cells via a mechanism characteristic of apoptosis. In vitro data demonstrates that following exposure to BCX-4208 and dGuo, dGTP in human lymphocytes is elevated and a 5–8 fold increase in dGTP results in 50% inhibition of lymphocyte proliferation. Flow cytometric analyses of human lymphocytes using annexin-V staining reveal that BCX-4208 in the presence of dGuo induces cellular apoptosis not only in T cells (CD3+), but also in B cells (CD20+; CD19+) (Table 1). BCX-4208 is orally bioavailable in mice, can achieve maximal inhibition of PNP, and elevates plasma dGuo levels to 3–5 μM (predose levels &amp;lt; 0.004 μM), which is similar to levels seen in PNP deficient patients and to levels needed to cause apoptosis in T and B-cells. These data support the evaluation of BCX-4208 in the treatment of not only T-cell mediated diseases but also B-cell mediated diseases. BCX- 4208 is currently undergoing early clinical investigation in patients with psoriasis. Table 1. Cell subsets % Apoptotic cells mean ± SEM (n = 4–7) Vehicle Treatment group *p ≤ 0.01 compared to vehicle CD3+ 7.2 ± 0.9 18.3 ± 3.7* CD20+ 24.0 ± 3.6 41.8 ± 6.2* CD19+ 25.0 ± 3.1 51.6 ± 7.4*