gebhart/patrepeval huggingface dataset:
OXI1 and DAD Regulate Light-Induced Cell Death Antagonistically through Jasmonate and Salicylate Levels (2019)

Singlet oxygen produced from triplet excited chlorophylls in photosynthesis is a signal molecule that can induce programmed cell death (PCD) through the action of the OXIDATIVE STRESS INDUCIBLE 1 (OXI1) kinase. Here, we identify two negative regulators of light-induced PCD that modulate <i>OXI1</i> expression: DAD1 and DAD2, homologs of the human antiapoptotic protein DEFENDER AGAINST CELL DEATH. Overexpressing <i>OXI1</i> in Arabidopsis (<i>Arabidopsis thaliana</i>) increased plant sensitivity to high light and induced early senescence of mature leaves. Both phenomena rely on a marked accumulation of jasmonate and salicylate. <i>DAD1</i> or <i>DAD2</i> overexpression decreased <i>OXI1</i> expression, jasmonate levels, and sensitivity to photooxidative stress. Knock-out mutants of <i>DAD1</i> or <i>DAD2</i> exhibited the opposite responses. Exogenous applications of jasmonate upregulated salicylate biosynthesis genes and caused leaf damage in wild-type plants but not in the salicylate biosynthesis mutant <i>Salicylic acid induction-deficient2</i>, indicating that salicylate plays a crucial role in PCD downstream of jasmonate. Treating plants with salicylate upregulated the <i>DAD</i> genes and downregulated <i>OXI1</i> We conclude that OXI1 and DAD are antagonistic regulators of cell death through modulating jasmonate and salicylate levels. High light-induced PCD thus results from a tight control of the relative activities of these regulating proteins, with DAD exerting a negative feedback control on <i>OXI1</i> expression.
Nano-scale chemical and biological sensors (2005)

Nano-engineered devices with potential for trace level detection of chemical or biological species are investigated. The sensor system is a ChemFET device based on micro- and nano-scale silicon wires. The sensor response to changes in pH reveals a significantly higher sensitivity of nano-scale devices compared to micro-scale devices. By immobilizing DNA probe molecules on the silicon wire surface, the ChemFET devices are rendered specific to this DNA sequence. Differential measurements minimize the effects of non-specific binding. At a concentration of C<sub>DNA</sub>=10&#956;M, two different single stranded 24-base DNA oligonucleotides have been clearly distinguished in the sensor response. DNA hybridization on the silicon wire surface is further corroborated by fluorescence spectroscopy and analysis of characteristic time constants in the sensors response.
Lateral Pedicle Control During Laparoscopic Radical Prostatectomy: Refined Technique (2005)

No AccessJournal of UrologyUrological Survey: Urolithiasis, Endourology and Laparoscopy1 Sep 2005Lateral Pedicle Control During Laparoscopic Radical Prostatectomy: Refined Technique Ralph V. ClaymanM.D. Ralph V. ClaymanRalph V. Clayman More articles by this author View All Author Informationhttps://doi.org/10.1097/S0022-5347(01)68452-0AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Lateral Pedicle Control During Laparoscopic Radical Prostatectomy: Refined Technique." The Journal of Urology, 174(3), pp. 930–931 © 2005 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 174Issue 3September 2005Page: 930-931 Advertisement Copyright & Permissions© 2005 by American Urological Association, Inc.MetricsAuthor Information Ralph V. Clayman More articles by this author Expand All Advertisement PDF DownloadLoading ...
Proposal for a study of laser acceleration of electrons using micrograting structures at ATF (Phase 1) (1989)

We propose to investigate new methods of particle acceleration using a short-pulse CO{sub 2} laser as the power source and grating-like structures as accelerator cavities''. Phase I of this program is intended to demonstrate the principle of the method. We will focus the laser light to a 3 mm line on the surface of the microstructure. The structure is used to transform the electric field pattern of the incoming transversely polarized laser beam to a mode which has a component along the electron beam direction in the vicinity of the surface. With 6 mJ of laser energy and a 6 ps pulse length, the electric field in the spot will be around 1 GV/m. The electron beam from the Brookhaven Accelerator Test Facility (ATF) will be focused transversely within the few micron transverse dimension of the microstructure. The maximum expected acceleration for a 1 GV/m field and a 3 mm acceleration length is 3 MeV. 17 refs., 11 figs., 2 tabs.
Clinical studies of prostatic cancer imaging with radiolabeled antibodies against prostatic acid phosphatase. (1984)

Conventional antibodies against prostatic acid phosphatase, labeled with iodine-131, have been administered to patients with prostatic carcinoma for the external scintigraphic imaging of tumors containing prostatic acid phosphatase (radioimmunodetection). The method has been found to be safe and reliable for imaging of primary tumors and non-bone metastases, even differentiating between lung tumors of prostatic and pulmonary origin.
PROTEOMIC ANALYSIS OF VITREOUS BIOPSY TECHNIQUES (2012)

Proteins and peptides collected from vitreous needle biopsies are nearly equivalent to those obtained from a vitreous cutter instrument. This study suggests both techniques may be used for most proteomic and biomarker discovery studies of vitreoretinal diseases, although a minority of proteins and peptides may differ in concentration.
Rapid and Reversible Hydrogen Storage in Clathrate Hydrates Using Emulsion‐Templated Polymers (2008)

A method for greatly accelerating the storage of gases such as hydrogen in clathrates by supporting the clathrate phase on a highly macroporous emulsion-templated polymer is presented. The gravimetric penalty is low due to the low bulk density of the support, no mechanical mixing is required, and the system is fully recyclable over multiple charge/ discharge cycles.
A 17β-Estradiol–Progesterone Oral Capsule for Vasomotor Symptoms in Postmenopausal Women: A Randomized Controlled Trial (2018)

(Abstracted from Obstet Gynecol 2018;132:161–170) After the first publication of Women's Health Initiative findings in 2002, many women stopped taking US Food and Drug Administration (FDA)–approved, hormone therapy (HT) and started using non–FDA-approved, “natural” compounded HT believing that it was a safer option. In 2015, it was estimated that 1 million to 2.5 million US women used the unapproved, compounded HT.
Current and future applications of HPTE insulated cables systems (2018)

HPTE insulated cables represent an attractive alternative to traditional cables insulated with crosslinkable materials. Thanks to a set of advantages, mainly due to the use of thermoplastic PP based insulation, superior performances can be achieved for cables with HPTE insulation. After an important experience in the field of MV cables, now HPTE insulation is being extended to HVAC and HVDC areas. In the field of HVAC, a cable length (1000 mm2 Cu 150 kV with HPTE insulation) has been installed in the Italian Transmission network and is in service since 2013. In HVDC important qualifications have been achieved in 320 kV, 350 kV and recently 600 kV voltage class, at high conductor temperature (90°C) and including both VSC and LCC typology. These results have been obtained thanks to an extensive work performed on materials development and technological improvements, for cables and accessories. The paper describes the developments performed and the results achieved, that are very promising especially in view of possible applications of HPTE insulated cables for EHVDC systems.
A mobile robot: Sensing, planning and locomotion (2005)

A mobile robot architecture must include sensing, planning, and locomotion which are tied together by a model or map of the world based on sensor information, apriori knowledge and generic models. The architecture of a Stanford's autonomous mobile robot is described including its distributed computing system, locomotion, and sensing. Additionally, some of the issues in the representation of a world model are explored. Sensor models are used to update the world model in a uniform manner, and uncertainty reduction is discussed.
Less is more: Avoiding the LIBS dimensionality curse through judicious feature selection for explosive detection (2015)

Despite its intrinsic advantages, translation of laser induced breakdown spectroscopy for material identification has been often impeded by the lack of robustness of developed classification models, often due to the presence of spurious correlations. While a number of classifiers exhibiting high discriminatory power have been reported, efforts in establishing the subset of relevant spectral features that enable a fundamental interpretation of the segmentation capability and avoid the 'curse of dimensionality' have been lacking. Using LIBS data acquired from a set of secondary explosives, we investigate judicious feature selection approaches and architect two different chemometrics classifiers -based on feature selection through prerequisite knowledge of the sample composition and genetic algorithm, respectively. While the full spectral input results in classification rate of ca.92%, selection of only carbon to hydrogen spectral window results in near identical performance. Importantly, the genetic algorithm-derived classifier shows a statistically significant improvement to ca. 94% accuracy for prospective classification, even though the number of features used is an order of magnitude smaller. Our findings demonstrate the impact of rigorous feature selection in LIBS and also hint at the feasibility of using a discrete filter based detector thereby enabling a cheaper and compact system more amenable to field operations.
ChemInform Abstract: Steric and Electronic Effects on the Weiss Reaction. Isolation of 1:1 Adducts. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Supplementary Data from Rebalancing Protein Homeostasis Enhances Tumor Antigen Presentation (2023)

&lt;p&gt;HSP990 MS Data&lt;/p&gt;
Control of the Nickel‐Catalyzed Cooligomerization of Butadiene with Schiff Bases by Cocatalysts (1977)

2:1 Adducts of type (1), (2), or (3) are formed from butadiene and Schiff bases, depending uponthe substitudents R and the substrate purity. In the presence of very weakly protic compounds (e.g. morpholine) amines of type (1) are obtained.
Abstract 20347: Kidney Transplantation in a Patient Lacking Cytosolic Phospholipase A2 Leads to Urinary Prostacyclin and Thromboxane A2 Metabolites Within Normal Ranges (2016)

Measurements of metabolites of prostacyclin and thromboxane A2 (TXA2) in the urine have been held as the best estimates of eicosanoid production in the circulation. As such, measurement of these ur...
Effect of Sulfur Concentration on the Morphology of Carbon Nanofibers Produced from a Botanical Hydrocarbon (2008)

Carbon nanofibers (CNF) with diameters of 20-130 nm with different morphologies were obtained from a botanical hydrocarbon: Turpentine oil, using ferrocene as catalyst source and sulfur as a promoter by simple spray pyrolysis method at 1,000 °C. The influence of sulfur concentration on the morphology of the carbon nanofibers was investigated. SEM, TEM, Raman, TGA/DTA, and BET surface area were employed to characterize the as-prepared samples. TEM analysis confirms that as-prepared CNFs have a very sharp tip, bamboo shape, open end, hemispherical cap, pipe like morphology, and metal particle trapped inside the wide hollow core. It is observed that sulfur plays an important role to promote or inhibit the CNF growth. Addition of sulfur to the solution of ferrocene and turpentine oil mixture was found to be very effective in promoting the growth of CNF. Without addition of sulfur, carbonaceous product was very less and mainly soot was formed. At high concentration of sulfur inhibit the growth of CNFs. Hence the yield of CNFs was optimized for a given sulfur concentration.
A phase 1b food effect study of the first-in-class, oral, selective inhibitor of nuclear export (SINE) selinexor (KPT-330) in patients (pts) with advanced sarcomas. (2014)

10587 Background: Sarcomas are heterogeneous diseases with multiple genetic abnormalities. XPO1 inhibition can restore the activity of multiple tumor suppressor proteins (TSP) including p53, Rb, and p27; and reduce cyclins and Akt. Selinexor is an oral XPO1 inhibitor that showed potent anti-sarcoma activity in preclinical ASPS, lipo- and bone sarcomas, and preliminary clinical activity in a phase 1 study. Methods: Oral selinexor was given at 30 mg/m2 twice weekly in capsule or tablet form based on an ongoing Phase 1. Appetite stimulants and anti-nausea agents were given. Pharmacokinetic (PK) analyses were performed under fasting and fed states (low vs high fat content). Paired tumor biopsies were obtained. Response evaluation was every 8 weeks (RECIST 1.1). All pts had documented progressive disease (PD) on study entry. Results: 16 evaluable pts (7 M/9 F; median age 55 yrs; median prior regimens: 3; ECOG PS 0/1: 11/6) including 5 leiomyo- (LMS), 4 lipo- (LPS), 3 synovial (SS), and 4 other sarcomas. Grade 3-4 toxicities in cycle 1 included thrombocytopenia without bleeding (12%) and hyponatremia (6%). The most common grade 1/2 AEs in cycle 1 were: nausea (59% G1/6% G2), fatigue (29%/29%), diarrhea (41%/6%), anorexia (18%/6%). PK in 11 patients showed similar exposures (AUC0-inf 3675 vs 3574 ng·hr/mL) of the drug in capsules or tablets; however, food (regardless of fat content) was associated with ~15% increased exposure versus fasted state. Analyses of tumor biopsies during treatment showed that selinexor resulted in nuclear localization of p53 and FOXO1, reduction in XPO1, reduced Ki67 index, increased apoptosis. Response was evaluable in 16 pts: (a) LMS: 3 stable disease (SD, 1 pt with 12% shrinkage), 2 PD; (b) LPS: 4 SD (1 pt with 10% shrinkage); (c) SS 3 PD; (d) chondrosarcoma: 1 SD, 1 PD; (e) chordoma: 1 SD; (f) spindle cell: 1 PD. 9 of the 16 pts remain on study (75-121 days). Conclusions: Selinexor should be taken with food and is generally well tolerated in pts with supportive care. Tumor shrinkage and disease stabilization was observed in a variety of soft tissue sarcomas leading to expansion of the study. Additional studies of selinexor in soft tissue sarcomas are planned. Clinical trial information: NCT01896505.
Abstract 4355: Use of MnSOD tet on transgenic mice as a model for evaluating irradiation protection and mitigation (2012)

Abstract Manganese superoxide dismutase (MnSOD) is a mitochondrial enzyme responsible for the dismutation or reduction of superoxide produced by cellular respiration. Absence of MnSOD is lethal two to three days after birth. Following irradiation there is an increase in superoxide production which combined with nitric oxide can result in the formation of the highly reactive radical peroxynitrite. Increased expression of MnSOD in a cell increases survival by the reduction of superoxide produced following irradiation. Decreased MnSOD production has resulted in decreased survival following irradiation. To better understand the role of MnSOD in cellular respiration as well as protecting the cell from irradiation damage, we have developed a MnSOD tet on mouse which has no MnSOD activity. In the absence of doxycycline the homozygous MnSOD tet on mouse does not survive past 2 or 3 days after birth. If doxycycline (2 µg/ml) is added to the water of heterozygous mothers, the MnSOD tet on mice develop normally and are fertile as long as they remain on the doxycycline treated water. Long term bone marrow cultures (LTBMCs) were established from homozygous MnSOD tet on mice, heterozygous tet on mice and control C57BL/6J mice. The cultures from the control mice had more hematopoietic cell activity than the MnSOD tet on cultures. To determine when the MnSOD gene is turned on after addition of doxocycline, bone marrow stromal cell lines were developed from the LTBMCs were incubated in 1 µg doxocycline/ml media for time points up to 24 hr, RNA was extracted and RT-PCR for the MnSOD transgene was performed. By 12 hours there was an increase in MnSOD RNA expression in the MnSOD tet on cells. Removal of the doxycycline resulted in a decrease in MnSOD RNA by 1 hr in the MnSOD tet on cells as well as the heteroxyzous cells. This mouse model will be useful for testing new compounds for radiation protection and mitigation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4355. doi:1538-7445.AM2012-4355
Quantifying violations of destination-based forwarding on the internet (2012)

Initially, packet forwarding in the Internet was destination-based -- that is, a router would forward all packets with the same destination address to the same next hop. In this paper, we use active probing methods to quantify and characterize deviations from destination-based forwarding in today's Internet. From over a quarter million probes, we analyze the forwarding behavior of almost 40,000 intermediate routers. We find that, for 29% of the targeted routers, the router forwards traffic going to a single destination via different next hops, and 1.3% of the routers even select next hops in different ASes. Load balancers are unlikely to explain these AS-level variations, and in fact we uncover causes including routers inside MPLS tunnels that otherwise employ default routes. We also find that these violations can significantly affect the results of measurement tools that rely on destination-based forwarding, and we discuss some ideas for making these tools more robust against these violations.
The pressure-volume relationship of the heart: Past, present and future (2010)

The pressure-volume relationship of the heart was first reported more than a century ago. It was not widely accepted, however, until the mid-1970s. The pressure-volume diagram became a central theme of cardiac mechanics once it was shown to be a good representation of ventricular mechanics. Early in 1980s, the introduction of the ventricular interaction with afterload using effective arterial elastance made it possible to translate ventricular mechanical properties represented by the pressure-volume relationship to the pumping ability of the heart. Furthermore incorporating the framework of ventricular arterial interaction into the classic Guyton's circulatory equilibrium early in 2000s enabled us to express quantitatively how mechanical properties of the ventricles and vascular systems determine the circulatory equilibrium. Successful quantitative descriptions of circulatory equilibrium using the pressure-volume concept would promote basic cardiovascular physiology and accelerate its clinical applications.
Disordering of CdZnSe/ZnSe Strained Layer Superlattices by Ion Implantation (1995)

We report the first confirmation of disordering of CdZnSe/ZnSe strained-layer superlattices (SLSs) by ion implantation. Ne was used for the ion species. Both the as-grown sample and the sample annealed without ion implantation showed periodic depth profiles in secondary ion mass spectrometry (SIMS) analyses and several orders of well-resolved double-crystal X-ray satellite peaks due to SLS periodic structure. However, the SIMS periodic profiles and the satellite peaks completely disappeared in the Ne-implanted sample, indicating that the SLS structure was disordered by the ion-implantation and not caused by the annealing process.
An electric vehicle charging system with 'universal' inductive interface (2002)

This paper describes the design of an inductive interface for an electric vehicle (EV) charging system based on a coaxial winding power transformer. The inductive interface is a separable transformer providing a means to 'plug-in' an EV without the need for metal-to-metal contact of exposed conductors. The proposed design is 'universal' in that dimensions can be selected which will accommodate more than an order of magnitude range of power ratings without imposing significant performance degradation. Interface geometry standardization and the configuration of the core and windings are shown to have important effects on the demands on the user, the EV infrastructure, the distribution of stationary and mobile weight, and the power electronic converter requirements. Design methodology for the proposed approach is summarized and experimental results of a laboratory prototype are presented to verify the design theory.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Federated Deep Learning Meets Autonomous Vehicle Perception: Design and Verification (2022)

Realizing human-like perception is a challenge in open driving scenarios due to corner cases and visual occlusions. To gather knowledge of rare and occluded instances, federated learning assisted connected autonomous vehicle (FLCAV) has been proposed, which leverages vehicular networks to establish federated deep neural networks (DNNs) from distributed data captured by vehicles and road sensors. Without the need of data aggregation, FLCAV helps preserve privacy while reducing communication costs compared with conventional centralized learning. However, it is challenging to determine the network resources and road sensor placements for multi-stage training with multi-modal datasets in multi-variant scenarios. This article presents networking and training frameworks for FLCAV perception. Multi-layer graph resource allocation and vehicle-road contrastive sensor placement are proposed to address the network management and sensor deployment problems, respectively. We also develop CarlaFLCAV, a software platform that implements the above system and methods. Experimental results confirm the superiority of the proposed techniques compared with various benchmarks.
Structural and functional studies of SIZ1, a PIAS-type SUMO E3 ligase fromArabidopsis (2010)

Small ubiquitin-like modifier (SUMO) is a post-translational modifier peptide that is involved in several biological processes in eukaryotes. Arabidopsis SIZ1, a SUMO E3 ligase, is an ortholog of the mammalian PIAS (Protein Inhibitor of Activated STAT) and yeast SIZ (SAP/Miz) proteins. SIZ1 contains all of the typical domains of PIAS/SIZ-type proteins, such as the PINIT, SAP, SP-RING, and plant-specific PHD domains. SIZ1 plays a pivotal role in controlling SUMOylation, and disruption of its function has been reported to affect stress responses, growth, and development. We performed a structural and functional analysis of SIZ1 by determining the phenotypes of siz1 knockout mutants transformed with SIZ1 alleles carrying point mutations in predicted SIZ1 domains. This study establishes that the diverse properties characteristic of SIZ1 are associated with specific domains and that they can be separated.
<title>New binary image compression scheme for various kinds of images</title> (1992)

This paper presents an efficient lossless data compression scheme for various kinds of binary images as line drawings and half-tone pictures. We studied a combination of preprocessing and Lempel-Ziv universal coding. To improve the compression ratio, we modified Lempel-Ziv universal coding by dividing its dictionary into classified sub-dictionaries. We obtained improved compression ratios in computer simulation on composite images consisting of mixed test and images.