gebhart/patrepeval huggingface dataset:
Computational music: birds of a feather discussion and demonstration (2012)

This session will provide an opportunity for CCSC NW Conference participants to interact with the keynote speaker, Professor Perry R. Cook. Prof. Cook will bring several of his musical instruments, and will answer questions about his talk, provide some demonstrations, and encourage discussion about computational music.
Handwritten document retrieval (2002)

This paper investigates the use of both typed and handwritten queries to retrieve handwritten documents. The recognition-based approach reported here is novel in that it expands documents in a fashion analogous to query expansion: Individual documents are expanded using N-best lists which embody additional statistical information from a hidden Markov model (HMM) based handwriting recognizer used to transcribe each of the handwritten documents. This additional information enables the retrieval methods to be robust to machine transcription errors, retrieving documents which otherwise would be unretrievable. Cross-writer experiments on a database of 10985 words in 108 documents from 108 writers, and within-writer experiments in a probabilistic framework, on a database of 537724 words in 3342 documents from 43 writers, indicate that significant improvements in retrieval performance can be achieved. The second database is the largest database of on-line handwritten documents known to its.
Polymer particle formation using inkjet printing (2016)

Frontiers Events is a rapidly growing calendar management system dedicated to the scheduling of academic events. This includes announcements and invitations, participant listings and search functionality, abstract handling and publication, related events and post-event exchanges. Whether an organizer or participant, make your event a Frontiers Event!
Primary cutaneous nocardiosis due to Nocardia nova in a healthy woman . (2001)

We describe a 68-year-old healthy woman with an unusual skin manifestation of mycetoma. A dark reddish erythematous plaque was present on the dorsum of the left hand for over 10 years. A skin biopsy revealed sulphur granules in the abscess, and Nocardia nova was identified from the specimen. Treatment with dapsone resulted in significant improvement. We review the clinical features of cutaneous N. nova infections.
Carpe Diubiquitin (2010)

Viele Wege führen zum Ziel: Ubiquitinierungen verlaufen über die Bildung einer unüblichen Isopeptidbindung zwischen dem ε-Stickstoffatom eines Lysinrestes im Zielprotein und der C-terminalen Carboxygruppe von Ubiquitin. Mehrere komplementäre Syntheseansätze haben die Herstellung von Diubiquitinketten in Mengen ermöglicht, die für Struktur-Funktions-Analysen taugen, und fanden ihren Höhepunkt in der chemischen Totalsynthese aller sieben Diubiquitinketten.
Novel Cr‐PNP Complexes as Catalysts for the Trimerization of Ethylene. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Employing dynamic segmentation for effective co-located coexistence between Bluetooth and IEEE 802.11 WLANs (2003)

The emergence of Bluetooth as a defacto radio interface has allowed handheld electronic devices to be instantly interconnected as ad hoc networks. Recent studies show that since Bluetooth operates in the unlicensed 2.45 GHz frequency band, the presence of multiple piconets in the vicinity creates intermittent interference on signal reception which, in turn, degrades the overall throughput of the network. Another kind of interference, called as persistent interference, is the one generated by IEEE 802.11 enabled devices as they use the same frequency band as Bluetooth, and thus may lead to significant performance degradation. In order to cope up with both of these interference sources, this paper proposes an interference aware Bluetooth segmentation algorithm (IBLUES), where Bluetooth packet types are selected depending on the packet success probability, which is calculated based on the interference generated both by multiple piconets, as well as by IEEE 802.11 devices. Among other things, we show that when the number of bridge nodes are larger than five the propagation delay between piconets increases rapidly. We have also observed a drastic overhead in the current Bluetooth piconet switching procedure and conclude that future enhancements to this procedure are crucial to efficiency of Bluetooth-based ad hoc networking.
Resistivity of polydiacetylene gels (1985)

We have observed, for the first time, the major change in resistance which results from the collapse of the interconnected gel network at the gel–sol transition. The dc resistivity and ac resistivity (≤10 kHz) were measured as functions of temperature and concentration. At the gel–sol transition, the resistivity increases sharply; in some cases by almost two orders of magnitude. Quantitative analysis of the transport data for detailed comparison with the onset of shear modulus (exponents, etc.) is complicated by the simultaneous occurrence of the rod–coil transition and by a background ionic contribution which leads to finite conductance at concentrations below the critical concentration.
In vitro Fluence Rate Effects in Photodynamic Reactions with AIPcS4 as Sensitizer (1997)

It has been shown previously that the efficiency of photodynamic therapy (PDT) both in vivo and in vitro is dependent on fluence rate. In this study, different in vitro experiments showed that tetrasulfonated aluminum phthalocyanine (AIPcS4) is more efficient in photosensitization if the light is delivered at low fluence rate. Erythrocyte damage, virus inactivation and photooxidation of reduced glutathione (GSH) and histidine were all enhanced if light was delivered at 100 W/m2 as compared to 500 W/m2. Bleaching did not occur under these conditions. Oxygen depletion, shown to be important in fluence rate effects observed in vivo, does not seem to be involved. On theoretical grounds saturation of the triplet state is not likely under these conditions. A possible explantation for the observed fluence rate effects might be found in different reaction pathways, that are favored under high or low fluence rate illuminations. These reactions might involve uni- or bimolecular reactions of intermediate products, resulting in less efficiency at higher fluence rate. It proves to be important, under all circumstances, to monitor fluence rate, because a change in fluence rate, even with similar total fluences, might influence photobiological results in an unexpected way.
C1q-Containing Immune Complexes Purified from Sera of Juvenile Rheumatoid Arthritis Patients Mediate IL-8 Production by Human Synoviocytes: Role of C1q Receptors (1999)

Immune complexes that vary in size and composition are present in the sera and synovial fluid of juvenile rheumatoid arthritis (JRA) patients. They are believed to be potent inducers of the ongoing inflammatory process in JRA. However, the precise composition and role of these complexes in the pathophysiology of JRA remain unclear. We hypothesized that circulating ICs have the potential to interact with resident joint synovial fibroblasts (synoviocytes) and induce the expression of inflammatory cytokines. To test this hypothesis, cultures of synoviocytes from healthy individuals were treated with ICs isolated from the sera of JRA patients. Studies reported in this work demonstrate that IgM affinity-purified ICs from the sera of JRA patients contain IgM, C1q, IgG, and C3 to a variable extent. These ICs induce IL-8 mRNA and protein production in normal synoviocytes. Our data indicate that C1q in these ICs mediates, in part, IL-8 induction in synoviocytes. This is based on our findings of C1q-binding proteins for collagen stalks (cC1qR) and globular heads (gC1q-binding protein) of C1q in synoviocytes. In addition, collagen stalk and to some extent globular head fragments of C1q inhibit IC-mediated IL-8 induction in synoviocytes. Together, these findings provide evidence for a novel mechanism of IL-8 production by synoviocytes, which could play a key role in inflammation by recruiting leukocytes to synovial tissue and fluid-and subsequently contributing to joint disease.
P13.22: Real time velocity profile of uterine artery (UtA) and vein (UtV) by global acquisition and signal processing (GASP) software for multigate spectral Doppler analysis (MSDA) (2006)

To characterize the velocity profiles (VP) of the UtA and UtV in the 1st, 2nd and 3rd trimesters. The MSDA system consisted of commercial ultrasound machine (Aloka SSD1400), a personal computer and a proprietary electronic board. Interrogated vessels consisted of the UtA and UtV in a total of 43 singleton uncomplicated ongoing pregnancies. Velocity profiles, relative wall distension rate [WDR (%)] and shear rate [WSR (1/s)] were calculated over multiple consecutives cardiac cycles. The designation of arterial laminar flow was applied if one peak occurred in systole, while if > 1 peak occurred in systole flow was classified as turbulent. Statistical analysis consisted of Spearman correlation. UtA and UtV displayed a laminar flow pattern, except in 5 (12%) cases, where UtA flow in these 5 cases were turbulent, and confined to only one UtA. Mean UtA WDR (left, 1.7 ± 1.0; right, 1.5 ± 0.7), and mean UtA WSR (left, 497 ± 234; right, 637 ± 260) were not correlated with each other, gestational age, or maternal age (mean 32.9 ± 5.2). Uterine artery notching was observed with conventional Doppler in 15 of 53 samples (28.3%) in the first trimester. In all cases with notching, the UtA VP characteristics were pseudo-laminar and WDR has second phase peak. Specifically, no reversal of UtA flow was seen with GASP and MSDA. Real-time velocity profiles of the UtA are now possible using MSDA and GASP software. This technology will clarify waveforms obtained by conventional Doppler. Current investigations are focused on interrogation of UtA and UtA in pathologic states, which have been associated with notching and increased pulsitility indices.
Local stability analysis of piecewise affine systems (2003)

This paper is concerned with the local stability of a piece-wise affine system. In terms of piecewise quadratic Lyapunov functions, we derive a new matrix inequality condition that explicitly characterizes an inner approximation of the domain of attraction for the piecewise affine system. We also show the effectiveness of the present method by two numerical examples.
ChemInform Abstract: Efficient Synthesis of γ‐Oxo‐ and γ‐Hydroxy‐α‐amino Acids. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Purification, molecular cloning and heterologous expression of a glutathione S-transferase from the Australian sheep blowfly (Lucilia cuprina) (1994)

Three glutathione S-transferases from Lucilia cuprina (Australian sheep blowfly) pupae were purified by affinity chromatography and anion-exchange chromatography. One isoenzyme was composed of M(r)-24,800 subunits, and two isoenzymes had subunits of M(r) 23,900. The M(r)-23,900 subunits showed immunological identity and were immunologically distinct from the M(r)-24,800 subunits. All three enzymes were active with the substrate 1-chloro-2,4-dinitrobenzene and had low activity with 1,2-dichloro-4-nitrobenzene. A cDNA clone encoding a M(r)-23,900 subunit (LuGST1) was isolated and sequenced. The sequence has close similarities (> 81%) to that of GSTs from the fruitfly Drosophila melanogaster and Musca domestica (housefly). The deduced amino acid sequence of the Lu GST1 subunit showed no significant similarity to that of the mammalian GSTs to the Alpha, Mu and Pi classes, but shows some similarity (33%) over the first 100 residues with the rat subunit 12 Theta-class GST. Southern blots of genomic DNA hybridized with the LuGST1 cDNA identified many hybridizing fragments. Taken together, these data indicated that the L. cuprina genome contains multiple glutathione S-transferase genes.
Residual stresses in composites: Measurement, modeling and effects on thermo-mechanical behavior (1993)

The symposium had three interrelated objectives: first, to present developments in the measurement of residuals in composites; second, to present analytical predictions of residual stresses and their impact on composite properties; and, finally, to document the role of the residual stresses during thermo-mechanical excursions of the composites. Based on the above goals, the proceedings have been divided into two sections. Since many of the papers contain both experimental measurements and analytical predictions, Section I is entitled Measurement and Modeling.'' Section II is entitled Thermo-Mechanical Behavior.'' Individual papers have been processed separately for inclusion in the appropriate data bases.
Abstract B012: Histone demethylase JMJD1A promotes the generation of androgen receptor variant 7 (AR-V7) in prostate cancer cells (2018)

Abstract Generation of androgen receptor (AR) splicing variant, AR-V7, has been shown to contribute to the resistance of prostate cancer to androgen deprivation therapy and development of castration-resistant prostate cancer (CRPC). We and others have reported that histone demethylase JMJD1A promotes the transcriptional activity of AR by functioning as an AR coactivator. Here, we identified a new role for JMJD1A in the generation of AR-V7 in prostate cancer cells through interaction with HNRFPF. Knockdown of JMJD1A or HNRNPF reduced the mRNA and protein level of AR-V7 but had little effect on the full-length AR (AR-FL). Mechanistically, we found that JMJD1A and HNRNPF cooperatively bound to a polyG motif adjacent to the 5′ splicing site of Exon3b of AR gene, where they promoted the assembly of splicesome. Re-expression of AR-V7 in the JMJD1A-knockdown cells partly rescued the growth defect of prostate cancer cells in vitro and in the mouse xenograft model. The staining of AR-V7 paralleled that of JMJD1A or HNRNFP in a human prostate cancer tissue microarray. Together, our data reveal that JMJD1A enhances the castration-resistant growth of prostate cancer cells through coactivation of AR-FL and generation of AR-V7. Citation Format: Lingling Fan, Fengbo Zhang, Ladan Fazli, Martin Gleave, Xuesen Dong, Jianfei Qi. Histone demethylase JMJD1A promotes the generation of androgen receptor variant 7 (AR-V7) in prostate cancer cells [abstract]. In: Proceedings of the AACR Special Conference: Prostate Cancer: Advances in Basic, Translational, and Clinical Research; 2017 Dec 2-5; Orlando, Florida. Philadelphia (PA): AACR; Cancer Res 2018;78(16 Suppl):Abstract nr B012.
Preclinical assessment of hepatocyte‐targeted MR contrast agents in stable human liver cell cultures (1998)

Much effort has been expended in the search for hepatocyte-specific MR contrast agents to improve the detection and characterization of liver tumors. The purpose of this study was to establish human hepatocyte cell cultures to preclinically assess hepatocyte-targeted magnetopharmaceuticals. Cultured human hepatocytes were sandwiched between two layers of collagen preserving both hepatocyte function and morphology over prolonged period of time. Cultures (n = 37) were subsequently used to test different fluorescinated MR contrast agents. Plain and rhodaminated monocrystalline iron oxide particles (MION and MION-rh) and asialoglycoprotein-receptor-specific rhodaminated asialofetuin coupled to MION (MION-ASF-rh) were prepared. Competition experiments of these agents were performed with D(+)-galactose to study the specificity of galactose-mediated cell uptake. To assess the impact of cell integrity on cell uptake, functional experiments with CCl4 were performed. Normal cell cultures showed significantly higher fluorescence light emission after incubation with hepatocyte-directed ASF-MION-rh than after incubation with MION-rh. Competition experiments of ASF-MION-rh with galactose showed a dose-dependent decrease of calibrated fluorescence light emission. Cell cultures treated with CCl4 demonstrated a dose-dependent significant reduction of calibrated fluorescence light emission, indicating reduced uptake of ASF-MION-rh. Our data demonstrate that stable human hepatocyte cell cultures can be used to preclinically assess novel magnetopharmaceuticals. Different contrast agents may be directly compared to each other and may accelerate their preclinical design. Because the assay can be applied to cells from any species, it may represent an ideal test system before clinical trials of new cell-directed MR contrast agents.
Switched multi-radio transmission diversity in future access networks (2006)

In this paper we study packet scheduling algorithms which exploit multi-radio transmission diversity in a multi-radio access network. We view the packet scheduling process as a combination of user ...
Broad Frequency Shift of Parametric Processes in Epsilon-Near-Zero Time-Varying Media (2020)

The ultrafast changes of material properties induced by short laser pulses can lead to a frequency shift of reflected and transmitted radiation. Recent reports highlight how such a frequency shift is enhanced in spectral regions where the material features a near-zero real part of the permittivity. Here, we investigate the frequency shift for fields generated by four-wave mixing. In our experiment, we observed a frequency shift of more than 60 nm (compared to the pulse width of similar to 40 nm) in the phase conjugated radiation generated by a 500 nm aluminium-doped zinc oxide (AZO) film pumped close to the epsilon-near-zero wavelength. Our results indicate applications of time-varying media for nonlinear optics and frequency conversion.
Evidence that protein tyrosine kinase p56-Lck regulates the activity of phosphatidylinositol-3'-kinase in interleukin-2-dependent T-cells. (1993)

The relative levels of phosphatidylinositol-3'-kinase (PI3K) activity were measured in interleukin-2 (IL-2)-dependent helper (HT-2) and cytolytic (CTLL-2) T-cell clones that had been stably transfected with expression plasmids encoding either the normal p56-Lck kinase or a mutant version of this kinase, p56-Lck(Y505F), that has constitutively high levels of kinase activity. Stimulation of untransfected T-cells or of transfected T-cells containing increased levels of normal p56-Lck resulted in an approximate doubling of the relative amounts of total cellular PI3K activity. In contrast, T-cells producing the activated version of p56-Lck contained levels of PI3K activity comparable to or slightly higher than those found IL-2-stimulated control cells, even in the absence of IL-2. Assessments of the relative levels of PI3K activity in immunoprecipitates prepared with the use of anti-phosphotyrosine-specific antibodies revealed constitutively high levels of anti-phosphotyrosine-immunoprecipitable PI3K activity in T-cells containing p56-Lck(Y505F), as opposed to T-cells containing normal p56-Lck where increases in anti-PY-immunoprecipitable PI3K activity were IL-2-inducible. IL-2 stimulation of T-cells containing the normal p56-Lck kinase resulted in marked increases in the relative amounts of PI3K activity and p85 that were coimmunoprecipitated when using anti-p56-Lck antibodies. In contrast, PI3K activity and the p85 subunit of PI3K could be coimmunoprecipitated from T-cells producing the activated p56-Lck(Y505F) kinase even in the absence of IL-2 stimulation, implying constitutive association of PI3K with the activated Lck kinase. Taken together with previous studies showing that IL-2 induces rapid increases in the activities of both p56-Lck and PI3K in T-cells, these findings suggest that p56-Lck lies immediately upstream of PI3K in a signal transduction cascade initiated by the binding of IL-2 to its specific receptor on T-lymphocytes.
PPARγ knockdown by engineered transcription factors: exogenous PPARγ2 but not PPARγ1 reactivates adipogenesis (2002)

To determine functional differences between the two splice variants of PPARgamma (gamma1 and gamma2), we sought to selectively repress gamma2 expression by targeting engineered zinc finger repressor proteins (ZFPs) to the gamma2-specific promoter, P2. In 3T3-L1 cells, expression of ZFP55 resulted in >50% reduction in gamma2 expression but had no effect on gamma1, whereas adipogenesis was similarly reduced by 50%. However, ZFP54 virtually abolished both gamma2 and gamma1 expression, and completely blocked adipogenesis. Overexpression of exogenous gamma2 in the ZFP54-expressing cells completely restored adipogenesis, whereas overexpression of gamma1 had no effect. This finding clearly identifies a unique role for the PPARgamma2 isoform.
Is Increased Sexual Behavior a Symptom of Bipolar Disorder in Children and Adolescents? (2013)

While there is consensus that bipolar disorder exists in children and adolescents, its diagnostic criteria are debated. Excessive sexual behavior has been reported in youth who may have juvenile bipolar disorder (JBD), and has been termed “hypersexuality.” Although there is no universal definition of this term, this observation has led to a hypothesis that increased sexual behavior characterizes the bipolar syndrome in children and adolescents, and differentiates it from attention deficit hyperactivity disorder. Although this hypothesis is plausible, evidence for it is incomplete, because testing it definitively would require both establishing a standard definition of hypersexuality in children and adolescents, and also reaching consensus about the other nonsexual criteria for pediatric bipolar disorder. In addition, studies to test it would need to control factors other than JBD that are known to increase sexual behavior in children and adolescents. These include sexual abuse and related posttraumatic stress disorder, excessive exposure to sexual stimuli, psychiatric illness in general, and social variables such as family chaos and social stress. Some of these factors might increase sexual behavior in youth with bipolar disorder through psychodynamic mechanisms rather than as a result of the illness itself. Therefore, further research is needed to determine whether increased sexual behavior can serve as a diagnostically valuable criterion for bipolar disorder in children and adolescents, and whether it differentiates the disorder from other conditions known to be associated with increased sexual behavior in youth.
Heterogeneous Coordination Environments in Lithium-Neutralized Ionomers Identified Using 1H and 7Li MAS NMR (2012)

The carboxylic acid proton and the lithium coordination environments for precise and random Li-neutralized polyethylene acrylic acid P(E-AA) ionomers were explored using high speed solid-state 1H and 7Li MAS NMR. While the 7Li NMR revealed only a single Li coordination environment, the chemical shift temperature variation was dependent on the precise or random nature of the P(E-AA) ionomer. The 1H MAS NMR revealed two different carboxylic acid proton environments in these materials. By utilizing 1H-7Li rotational echo double resonance (REDOR) MAS NMR experiments, it was demonstrated that the proton environments correspond to different average 1H-7Li distances, with the majority of the protonated carboxylic acids having a close through space contact with the Li. Molecular dynamics simulations suggest that the shortest 1H-7Li distance corresponds to un-neutralized carboxylic acids directly involved in the coordination environment of Li clusters. These solid-state NMR results show that heterogeneous structural motifs need to be included when developing descriptions of these ionomer materials.