gebhart/patrepeval huggingface dataset:
Content-Based Musical Similarity Computation Using The Hierarchical Dirichlet Process. (2008)

[TODO] Add abstract here.
Nanomolar Potency Aminophenyltriazine CFTR Activator Reverses Corneal Epithelial Injury in a Mouse Model of Dry Eye (2020)

<b><i>Purpose:</i></b> Dry eye disorders are a major health care burden. We previously reported the identification of <i>N</i>-methyl-<i>N</i>-phenyl-6-(2,2,3,3-tetrafluoropropoxy)-1,3,5-triazine-2,4-diamine [cystic fibrosis transmembrane conductance regulator (CFTR)<sub>act</sub>-K267], which activated human wild-type CFTR chloride conductance with EC<sub>50</sub> ∼ 30 nM. Here, we report <i>in vivo</i> evidence for CFTR<sub>act</sub>-K267 efficacy in an experimental mouse model of dry eye using a human compatible ophthalmic vehicle. <b><i>Methods:</i></b> CFTR activation in mice <i>in vivo</i> was demonstrated by ocular surface potential difference (OSPD) measurements. Ocular surface pharmacodynamics was measured in tear fluid samples obtained at different times after topical administration of CFTR<sub>act</sub>-K267. Dry eye was produced by lacrimal duct cautery (LDC) and corneal epithelial injury and was assessed by Lissamine green (LG) staining. <b><i>Results:</i></b> OSPD measurements demonstrated a hyperpolarization of -8.6 ± 3 mV (standard error of the mean, 5 mice) in response to CFTR<sub>act</sub>-K267 exposure in low chloride solution that was reversed by a CFTR inhibitor. Following single-dose topical administration of 2 nmol CFTR<sub>act</sub>-K267, tear fluid CFTR<sub>act</sub>-K267 concentration was >500 nM for more than 6 h. Following LDC, corneal surface epithelial injury, as assessed by LG staining, was substantially reversed in 10 of 12 eyes receiving 2 nmol CFTR<sub>act</sub>-K267 3 times daily starting on day 2, when marked epithelial injury had already occurred. Improvement was seen in 3 of 12 vehicle-treated eyes. <b><i>Conclusion:</i></b> These studies provide <i>in vivo</i> evidence in mice for the efficacy of a topical, human use compatible CFTR<sub>act</sub>-K267 formulation in stimulating chloride secretion and reversing corneal epithelial injury in dry eye.
Label and Immobilization Free Detection and Differentiation of Tumor Cells (2018)

This paper presents an electrical impedance spectroscopy based microfabricated sensor capable of detecting and differentiating tumor cells at single cell accuracy. Cell labeling, device functionalization, or cell capture were not required. Device consisted of a microfluidic channel etched in silicon with semi-parallel gold electrodes fabricated on channel side-walls. Device was tested with three human tumor cell lines and latex beads. All cell lines and latex beads were successfully detected. Differentiation between tumor cells from different cell lines was shown to be possible by analyzing channel impedance at two signal frequencies. Estimates for population opacity values were statistically calculated to be 1.119, 0.257, 0.664, and 0.332 for latex beads, MDA-MB-231 cells, MCF-7 cells, and SK-OV-3 cells, respectively. This device demonstrates a simple, mass-producible, and cost-effective approach for tumor cell detection in clinical and research procedures.
Direct measurement of nonlocal interactions in the many-body localized phase (2022)

The interplay of interactions and strong disorder can lead to an exotic quantum many-body localized (MBL) phase of matter. Beyond the absence of transport, the MBL phase has distinctive signatures, such as slow dephasing and logarithmic entanglement growth; they commonly result in slow and subtle modifications of the dynamics, rendering their measurement challenging. Here, we experimentally characterize these properties of the MBL phase in a system of coupled superconducting qubits. By implementing phase sensitive techniques, we map out the structure of local integrals of motion in the MBL phase. Tomographic reconstruction of single and two-qubit density matrices allows us to determine the spatial and temporal entanglement growth between the localized sites. In addition, we study the preservation of entanglement in the MBL phase. The interferometric protocols implemented here detect affirmative quantum correlations and exclude artifacts due to the imperfect isolation of the system. By measuring elusive MBL quantities, our work highlights the advantages of phase sensitive measurements in studying novel phases of matter.
Future of wireless communication: RadioApps and related security and radio computer framework (2012)

This article introduces a novel flexible mobile device reconfiguration classes (MDRCs) framework which is expected to be applicable to future generation mass market radio devices. This framework sets the scene for a vision of a smooth evolution of reconfigurability features in mobile devices, paving the way from current, mainly static implementation choices toward a fully flexible device platform environment. For this flexible mobile device framework, baseband interfaces are introduced as they are currently discussed in ETSI reconfigurable radio systems standardization. Furthermore, this technical solution is positioned with respect to security requirements and the basic regulatory framework which is currently under revision in Europe. Indeed, the future revised Radio Equipment and Telecommunications Terminal Equipment Directive is expected to allow for such advanced reconfiguration, enabling users to acquire and install so-called RadioApps software components which may affect the compliance of a mobile device to the essential requirements of the Directive.
Dispersive and directional electrical conductivity and dielectric permittivity of conductive-mineral-bearing samples derived from multifrequency tensor electromagnetic induction measurements (2017)

Organic-rich mudrocks, hydrocarbon-bearing conventional formations, and source rocks generally contain pyrite, rutile, graphite, graphitic precursors, and other electrically conductive minerals in the form of veins, laminations, flakes, and grains. Under redox-inactive subsurface conditions, when an external electromagnetic (EM) field is applied to geomaterials containing conductive mineral inclusions, ions in pore-filling brine and charge carriers (electrons and holes) in electrically conductive mineral inclusions migrate, accumulate/deplete, and diffuse around impermeable host-inclusion interfaces. These EM-field-induced phenomena are referred to as perfectly polarized interfacial polarization (PPIP) phenomena, and they alter the effective electrical conductivity [Formula: see text] and effective relative dielectric permittivity [Formula: see text] of geomaterials. In addition, the relaxation process associated with such polarization phenomena and the time required to fully develop and dissipate the EM-field-induced polarization gives rise to frequency dispersion of [Formula: see text] and [Formula: see text] of geomaterials containing conductive mineral inclusions. A laboratory-based EM apparatus, referred to as a whole-core EM induction tool, was used to measure the directional, multifrequency EM response of brine-saturated 4 in diameter (10.16 cm diameter), 2 ft long (0.61 m long), glass-bead packs containing uniformly distributed pyrite and graphite inclusions. We then implemented a semianalytic (SA) EM forward model, referred to as the SA model, to compute the [Formula: see text] and [Formula: see text] of these conductive-mineral-bearing glass-bead packs. The estimated [Formula: see text] and [Formula: see text] of conductive-mineral-bearing packs exhibit directional and frequency dispersive characteristics, which can be explained using the theory of PPIP phenomena. Relative variations in [Formula: see text] and [Formula: see text] due to frequency dispersion were as large as [Formula: see text] and [Formula: see text], respectively, between the values estimated at 20 and 260 kHz. Computed values of [Formula: see text] of conductive-mineral-bearing packs were unusually large in the range of 10 3 –10 6 , whereas the corresponding values of [Formula: see text] exhibited strong dependence on volume content, size, and metallic nature of conductive mineral inclusions, brine salinity, and frequency. Furthermore, packs containing uniformly distributed pyrite and graphite inclusions exhibited conductivity and permittivity anisotropy in the range of one to two.
Chicken astrovirus as an aetiological agent of runting-stunting syndrome in broiler chickens (2018)

Despite descriptions of runting-stunting syndrome (RSS) in broiler chickens dating back over 40 years, the aetiology has not yet been described. A novel chicken astrovirus (CkAstV) was isolated in an LMH liver cell line from the intestines of chickens affected with RSS. Clinical RSS is characterized by retarded growth and cystic crypt lesions in the small intestine. In 1-day-old broiler chickens infected with the CkAstV isolate, virus was only detected in the intestinal epithelial cells during the first few days after infection. Notably, the preferred host cells are the crypt epithelial cells following initial replication in the villous epithelial cells, thus implying viral preference for immature intestinal cells. Nevertheless, the CkAstV isolate did not induce remarkable pathological changes, despite the presence of the virus in situ. Serial chicken-to-chicken passages of the virus induced increased virulence, as displayed by decreased weight gain and the presence of cystic lesions in the small intestine reproducing clinical RSS in chickens. The analysis of the full-length genome sequences from the isolated CkAstV and the CkAstV from the bird-to-bird passages showed >99 % similarity. The data obtained in this study suggest that the CkAstV isolate is capable of inducing RSS following serial bird-to-bird passages in broilers and is as an aetiological agent of the disease.
Mixed Protonic/Electronic Conductor Cathodes for Intermediate Temperature SOFCs Based on Proton Conducting Electrolytes (2008)

The electrical properties of doped SrCeO3 and BaCeO3 were studied as a function of temperature, and oxygen and water vapor partial pressure using electrochemical impedance spectroscopy. Rare-earth elements, such as Yb, Eu, and Sm, were used as cation dopants because of their multivalent oxidation state, low third ionization potential, and comparable ionic radius with cerium. Higher conductivity values were recorded doping SrCeO3 and BaCeO3 oxides with Yb. Partial conductivities and transport numbers were calculated from the conductivity measurements at different oxygen partial pressures using an established defect model. In an oxidizing condition, electron-hole conduction was dominant at high temperatures and decreased with decreasing the temperature and increasing the water vapor content in the gas atmosphere. BaCe0.9Yb0.1O3-delta presented the highest conductivity among the tested samples both in dry and wet oxygen atmospheres. Moreover, BaCe0.9Yb0.1O3-delta showed a mixed conduction of ions and holes at temperatures above 600 degrees C, suggesting that this perovskite-type oxide could be a possible cathode material in a solid oxide fuel cell (SOFC) based on a proton conductor electrolyte.
Rate-Splitting Multiple Access for Multi-Antenna Broadcast Channel with Imperfect CSIT and CSIR (2021)

Rate-splitting multiple access (RSMA) has appeared as a powerful transmission and multiple access strategy for multi-user multi-antenna communications. Uniquely, this paper studies the optimization of the sum-rate of RSMA with imperfect channel state information (CSI) at the transmitter (CSIT) and the receivers (CSIR). The robustness of the RSMA approach against imperfect CSIT has been investigated in the previous studies while there has been no consideration for the effects of imperfect CSIR. This motivates us to develop a robust design relying on RSMA in the presence of both imperfect CSIT and CSIR. Since the optimization problem for the design of RSMA precoder and power allocations to maximize the sum-rate is non-convex, it is hard to solve directly. To tackle the non-convexity, we propose a novel alternating optimization algorithm based on semidefinite relaxation (SDR) and concave-convex procedure (CCCP) techniques. By comparing simulation results with conventional methods, it turns out that RSMA is quite robust to imperfect CSIR and CSIT, thereby improving the sum-rate performance.
Perspective: Pivotal translational hematology and therapeutic insights in chronic myeloid hematopoietic stem cell malignancies (2022)

Despite much of the past 2 years being engulfed by the devastating consequences of the SAR-CoV-2 pandemic, significant progress, even breathtaking, occurred in the field of chronic myeloid malignancies. Some of this was show-cased at the 15th Post-American Society of Hematology (ASH) and the 25th John Goldman workshops on myeloproliferative neoplasms (MPN) held on 9th-10th December 2020 and 7th-10th October 2021, respectively. The inaugural Post-ASH MPN workshop was set out in 2006 by John Goldman (deceased) and Tariq Mughal to answer emerging translational hematology and therapeutics of patients with these malignancies. Rather than present a resume of the discussions, this perspective focuses on some of the pivotal translational hematology and therapeutic insights in these diseases.
A Novel Preservation Solution Prolonged Cold Storage in Mouse Cardiac Grafts. (2014)

Background: We developed a novel non-potassium preservation solution contains L-cysteine, glycine, ascorbic acid/ascorbic acid-2-phosphate magnesium to prolonged mouse cardiac grafts cold storage. Methods: B6 mice underwent heterotopic heart transplantation and the animals were derived into 3 groups: recipients with non-preserved grafts (control group), recipients with grafts preserved in HTK solution for 24 and 48 hours (HTK-group), and recipients with grafts preserved in the new solution, called Solution II for 24 and 48 hours (S-II group). Recipient serum and grafts were harvest for assay. Results: In both 24hr- and 48hr-preservation series (24h- and 48h-series), time for restoration of heartbeat after reperfusion in S-II group was significantly shorter than in HTK group (HTK-24h: 306.2±39.6sec, S-II-24h: 110.5±20.3sec, p<0.01; HTK-48h: 1537.5±454.7sec, S-II-48h: 640±286sec, p<0.01). In 48h-series, Release of serum LDH, CK in S-II-group was significantly lower to compare with HTK group. The graft survival of HTK-48h group is 0 day (n=9), but S-II group is 9d, 17d, >100d×2. Graft ATP level of S-II-48h was significantly higher than HTK-48h. In both 24 and 48h-series, S-II significantly inhibited graft apoptosis. Moreover, immunohistochemistry staining revealed that the CD68-positive macrophage infiltration in S-II group was significantly lower compared with HTK group. In 24h-series, graft 8-OHdG positive cells (%) were significantly lower in S-II compared with HTK. Consistent with histologic findings, serum 8-OHdG levels were significantly inhibited in S-II group. Furthermore, the mRNA expression of the IL-6, HO-1, iNOS, CD11b in S-II-48h group, were significantly lower, wherever Nrf2, NF-κB, Arg-1, HIF-1α, TGF-β were significantly higher than HTK-48h group (p<0.01). Conclusion: Hence our data indicated that the novel preservation solution impairs graft macrophage infiltration, inhibits inflammatory cytokines and myocardial apoptosis which results in attenuating mouse cardiac grafts cold ischemia-reperfusion injury and prolonging cold storage.
Design and performance evaluation of VLC indoor positioning system using optical orthogonal codes (2014)

In this paper, a VLC indoor positioning system utilizing optical orthogonal codes (OOCs) is proposed. The use of OOC is to distinguish different transmitted signals at the receiver, the trilateration method then calculate the position of receiver based on these distinguished signals. To expand the scale of system and use efficiently OOC resource, a strategy of reusing/combining codeword is proposed. We also create a combination of simulation and mathematical modeling to investigate the performance of proposed system. Numerical results confirm that the proposed system can achieve a good positioning accuracy level in average.
A rare case of esophageal metastasis from pancreatic ductal adenocarcinoma: a case report and literature review (2017)

Differentiating an esophageal metastasis from a PDAC primary versus a synchronous esophageal carcinoma is very difficult despite state-of-the-art diagnostic techniques performed at a high-volume tertiary cancer center. Extensive evaluation and continued follow-up of PDAC patients presenting with a synchronous esophageal lesion in a multidisciplinary setting may help ensure efficient and accurate management. In our case, neoadjuvant FOLFIRINOX and SBRT to the primary PDAC tumor followed by surgery has been an effective approach for this patient.
Minimizing human intervention in intravenous admixture practice (2010)

Journal Article Minimizing human intervention in intravenous admixture practice Get access Dennis A. Tribble, Pharm.D. Dennis A. Tribble, Pharm.D. Chief Technology Officer and Chief Pharmacy Officer ForHealth Technologies, Inc., 790 Fentress Boulevard, Daytona Beach, FL 32114-1214 Search for other works by this author on: Oxford Academic Google Scholar American Journal of Health-System Pharmacy, Volume 67, Issue 5, 1 March 2010, Pages 389–390, https://doi.org/10.2146/ajhp090144 Published: 01 March 2010
Proteins in normal, irradiated, and postmortem human brain quantitatively compared by using two-dimensional gel electrophoresis. (1984)

Using a combination of two-dimensional gel electrophoresis (2DE), silver staining, and computerized densitometry, we studied protein patterns in human cerebral cortex: normal fresh-frozen, fresh-frozen but previously irradiated, and post-mortem. The relative molecular mass of the resolved proteins ranged from 14 400 to 100 000, the isoelectric points from 4.75 to 7.0. The pattern of proteins (six of them identified) was essentially the same for all three groups. However, computerized densitometry demonstrated significant alterations in the density of several spots in the irradiated and postmortem groups as compared with the normal controls. Irradiated cortex showed statistically significant changes in only six spots (three increased and three decreased in density); postmortem material showed 20 altered spots (16 diminished and four increased). Evidently normal human cerebral cortex has a consistent protein pattern on 2DE, which is quantitatively (but not qualitatively) altered in irradiated and postmortem material. These findings provide a point of reference against which proteins from abnormal brain material can be compared, both qualitatively and quantitatively.
Commutation Failure Analysis in Multi-Infeed HVDC Systems (2010)

The commutation failure vulnerability of multi-infeed HVDC converters to ac side faults is analyzed. Faults in multi-infeed systems can cause commutation failure events in the nearby local converter or concurrently in both converters. The immunity of the system to both these events is investigated and suitably parameterized. “Commutation Failure Immunity Index” is calculated for multi-infeed systems with different ratings. Anomalous failure in valve current commutation due to voltage distortion has been investigated.
Recent Progress of the Lifetime of Organic Light‐Emitting Diodes Based on Thermally Activated Delayed Fluorescent Material (2019)

Recently, the external quantum efficiency and lifetime of organic light-emitting diodes (OLEDs) have been dramatically upgraded due to development of organic materials and device structure. In particular, an intramolecular or intermolecular complex based on thermally activated delayed fluorescent (TADF) materials has greatly contributed to improving OLED device performance. Although high external quantum efficiency has been the main objective of the development of TADF materials as hosts and emitters, recent interest has been directed towards the lifetime of TADF-material-based OLEDs. For the past several years, remarkable advances in the lifetime of phosphorescent and TADF OLEDs have been made using TADF materials as hosts or emitters in the emitting layer. Therefore, since TADF materials are useful as both hosts and emitters for a long lifetime, this work discusses the recent progress made in developing TADF materials for long-lifetime OLEDs.
Data from Discovery of JNJ-63576253, a Next-Generation Androgen Receptor Antagonist Active Against Wild-Type and Clinically Relevant Ligand Binding Domain Mutations in Metastatic Castration-Resistant Prostate Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;Numerous mechanisms of resistance arise in response to treatment with second-generation androgen receptor (AR) pathway inhibitors in metastatic castration-resistant prostate cancer (mCRPC). Among these, point mutations in the ligand binding domain can transform antagonists into agonists, driving the disease through activation of AR signaling. To address this unmet need, we report the discovery of JNJ-63576253, a next-generation AR pathway inhibitor that potently abrogates AR signaling in models of human prostate adenocarcinoma. JNJ-63576253 is advancing as a clinical candidate with potential effectiveness in the subset of patients who do not respond to or are progressing while on second-generation AR-targeted therapeutics.&lt;/p&gt;&lt;/div&gt;
In vitro Absorption Studies with Carvedilol Using a New Model with Porcine Intestine Called BM-RIMO (Boehringer-Mannheim Ring Model) (2011)

Carvedilol (CAS 72956-09-3, Dilatrend) is a beta-blocker with additional vasodilating, antiproliferative and antioxidative properties. It is indicated for the treatment of high tension (HT), coronary artery disease (CAD) and congestive heart failure (CHF). Carvedilol has been investigated in numerous in vivo studies and thus comparisons of in vitro results to in vivo observations are possible. In this publication the results of studies on the in vitro absorption of carvedilol in a new model called BM-RIMO (Boehringer-Mannheim ring model) using porcine intestine are reported. In particular the influence of absorption enhancers and of pH and the existence of absorption windows were examined and the relevance of the obtained data for in vivo conditions was estimated. The main route of carvedilol absorption seemed to be transcellular. In vitro as well as in vivo absorption decreased within the intestine in the following order: jejunum > ileum > colon. The highest amount of in vitro absorption of carvedilol was achieved in the jejunum at a neutral pH. Enhancers such as bile and the mucoadhesive agent chitosan had opposite effects on the absorption of the compound. The results indicate that BM-RIMO is a simple, cheap and fast tool for the investigation of the influence of absorption enhancers, pH and different parts of intestine on absorption. For carvedilol the in vitro model tends to overestimate absorption in the colon, possibly because of the lack of faeces.