gebhart/patrepeval huggingface dataset:
Selective Photocatalysis by Means of Molecular Recognition (2001)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTSelective Photocatalysis by Means of Molecular RecognitionSudeshna Ghosh-Mukerji, Hossam Haick, Mark Schvartzman, and Yaron PazView Author Information Department of Chemical Engineering Technion-Israel Institute of Technology, Haifa 32000, Israel Cite this: J. Am. Chem. Soc. 2001, 123, 43, 10776–10777Publication Date (Web):October 9, 2001Publication History Received20 July 2001Published online9 October 2001Published inissue 31 October 2001https://pubs.acs.org/doi/10.1021/ja0117635https://doi.org/10.1021/ja0117635rapid-communicationACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views1189Altmetric-Citations81LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Aromatic compounds,Degradation,Hydrocarbons,Impurities,Oxides Get e-Alerts
Ultrasound Needle Guidance System for Precision Vaccinations and Drug Deliver (2021)

Image-guided needles are currently used for drug delivery in bodies, but the additional time associated with aligning and maintaining the needle’s position results in increased patient discomfort or risk of invasion of the human body. In this paper, a needle guidance system using piezoelectric materials is designed and analyzed for precise drug delivery without damaging parts of the body and improving processing time. A piezoelectric generates an ultrasound wave that can propagate through different mediums, and a second piezoelectric crystal can receive that energy and convert it into voltage. A 1D real-time image represents the changes of the voltage induced in the double piezoelectric crystal. Extensive data analysis and visualization are done using different obstacles and location of the needle verified for other mediums. The presence of obstacles in between those crystals can be identified in the real-time grayscale image. The needle can reach its destination using this image information as directional guidance. This guided drug delivery improves patient recovery time and eliminates extra injuries that can be caused due to wrong needle injections, such as lumbar puncture-related nerve damage.
The visualisation of vitreous using surface modified poly(lactic-co-glycolic acid) microparticles (2010)

AIMS To demonstrate the potential use of in vitro poly(lactic-co-glycolic acid) (PLGA) microparticles in comparison with triamcinolone suspension to aid visualisation of vitreous during anterior and posterior vitrectomy. METHODS PLGA microparticles (diameter 10-60 microm) were fabricated using single and/or double emulsion technique(s) and used untreated or following the surface adsorption of a protein (transglutaminase). Particle size, shape, morphology and surface topography were assessed using scanning electron microscopy (SEM) and compared with a standard triamcinolone suspension. The efficacy of these microparticles to enhance visualisation of vitreous against the triamcinolone suspension was assessed using an in vitro set-up exploiting porcine vitreous. RESULTS Unmodified PLGA microparticles failed to adequately adhere to porcine vitreous and were readily washed out by irrigation. In contrast, modified transglutaminase-coated PLGA microparticles demonstrated a significant improvement in adhesiveness and were comparable to a triamcinolone suspension in their ability to enhance the visualisation of vitreous. This adhesive behaviour also demonstrated selectivity by not binding to the corneal endothelium. CONCLUSION The use of transglutaminase-modified biodegradable PLGA microparticles represents a novel method of visualising vitreous and aiding vitrectomy. This method may provide a distinct alternative for the visualisation of vitreous whilst eliminating the pharmacological effects of triamcinolone acetonide suspension.
Taxane Followed by Anthracycline or Vice Versa: Impact of Sequential Order on Breast Cancer Recurrence?—Reply (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Waveguide optical deflector for an optical disk tracking actuator using a surface acoustic wave device (1990)

Optical disks are widely used in data processing. However, one of the problems is slow access time compared with that of magnetic disks, because in the former dual mechanical actuators such as a galvanomirror or voice coils are used. To achieve higher speed access, it is necessary to replace mechanical components with an electronically controlled system. A surface acoustic device is introduced into the fine access actuator and its feasibility is tested. Less than 1-ms fine access can be expected.
ChemInform Abstract: Palladium‐Catalyzed Completely Linear‐Selective Negishi Cross‐Coupling of Allylzinc Halides with Aryl and Vinyl Electrophiles. (2014)

Abstract Efficient Negishi cross‐coupling reactions of prenylated and related β,γ‐unsaturated zinc bromides with aryl or hetaryl halides as well as vinyl triflates are developed using a Pd‐precatalyst containing the CPhos ligand.
Multimodality Radionuclide, Fluorescence, and Bioluminescence Small-Animal Imaging (2005)

The imaging of molecular events in the complex physiological interplay between organelles, cells, tissues, and organs in the whole organism is now more practical through the use of small-animal imaging technologies. Radionuclide based molecular imaging using single photon emission computed tomography (SPECT) and positron emission tomography (PET) scanners have been used for imaging intracellular enzymes, receptors, transporters, reporter gene expression, and cell trafficking in small animals such as mice and rats. Sensitive cooled charge-coupled device (CCD) cameras which detect emitted light from fluorescent and bioluminescent probes within an organism have been useful in imaging pathologic changes in diseases such as cancer and infectious disease in small-animal models. Each molecular imaging modality has differing strengths and weaknesses. However, the ability to generate molecular reporter strategies that can be applied in multiple detection systems will likely provide more robust imaging data sets than from any single modality. The ultimate function of multimodality reporter strategies will be to provide information about molecular targets in a continuum of research subjects from cells to small animals to human patients.
CT and MR imaging in staging non-small cell bronchogenic carcinoma: report of the Radiologic Diagnostic Oncology Group. (1991)

The accuracies of magnetic resonance (MR) imaging and computed tomography (CT) in determining tumor classification and assessing mediastinal node metastases were compared in a prospective cooperative study of 170 patients with non-small cell bronchogenic carcinoma. The sensitivity of CT in distinguishing T3-T4 tumors from T0-T2 tumors was 63%; specificity was 84%. These values for MR imaging were not significantly different (56% and 80%). With receiver operating characteristic (ROC) analysis, no difference existed between the accuracies of CT and MR imaging in diagnosis of bronchial involvement or chest wall invasion, but MR imaging was significantly more accurate than CT (P = .047) in diagnosis of mediastinal invasion. Lymph node sampling was performed in 155 patients (642 node stations). Cancerous nodes were found in 14% of stations in 21% of patients. There was no significant difference between the accuracies of CT and MR imaging in detecting mediastinal node metastases (N2 or N3); the sensitivities were 52% and 48%, respectively, and specificities were 69% and 64%. ROC analysis also showed no difference between CT and MR imaging.
Lack of hepatitis B virus DNA sequences in sera from patients with acute and chronic liver diseases diagnosed as non‐A, non‐B‐hepatitis (1986)

The sera of 15 individuals with transfusion-associated acute or chronic non A, non B hepatitis, which lacked hepatitis B virus markers, were tested for hepatitis B virus DNA by dot blot hybridization test. Three sera of two patients positive in this test, however, also gave positive results when the labeled plasmid was used as probe instead of labeled HBV-DNA, indicating false positive results in the initial test. In conclusion, the data indicated that sera of patients with confirmed non A, non B hepatitis do not contain DNA-sequences in the serum hybridizing with HBV-DNA.
Platinum nanowires with pronounced texture, controlled crystallite size and excellent growth homogeneity fabricated by optimized pulsed electrodeposition (2013)

Platinum nanowires with controlled texture and crystallite size were fabricated in nanoporous ion-track etched polycarbonate membranes by electrochemical deposition with different potential pulse sequences. The application of specific potential pulses ranging from −0.5 V to −1.3 V and reverse pulses with +0.2 V allows switching between a light 〈111〉 texture and a pronounced 〈100〉 texture along the nanowire axis. At the same time, the crystallite size determined by XRD was significantly increased from approx. 20 nm to 45 nm, yielding oligocrystalline wires, which are very difficult to obtain with Pt electrodeposition due to its pronounced tendency towards instantaneous nucleation. TEM verified the increase of the calculated average crystallite size of the Pt nanowires. We have been able to prove the necessity of each potential pulse and pulse duration by changing them in a systematical way. Key strategy to achieve large crystallite sizes and a pronounced texture was to reduce oversaturation of Pt adatoms during the reduction step and to preferentially dissolve lattice defects and nucleation sites by anodic removal. Additionally, the homogeneity of the Pt nanowire growth was evaluated for the applied pulse sequences by SEM. The results show that by reducing the deposition current density, the uniformity of the Pt nanowires was strongly enhanced. The proposed rational synthetic strategy allows to optimize the crystallinity, texture and monodispersity of Pt nanowires and is thus of considerable relevance for tailoring the functional properties of these structures.
A sum-of-harmonics time-domain method to distinguish harmonic and broadband signals during passive acoustic mapping of ultrasound therapies (2015)

Passive Acoustic Mapping (PAM), a novel technique for real-time monitoring of ultrasound-based therapies, performs passive beamforming of nonlinear acoustic emissions simultaneously received on an array of transducers. These emissions can be classified according to their frequency content into harmonic, indicative of nonlinear scattering, stable cavitation or tissue boiling, and broadband, indicative of inertial cavitation. However, the magnitude of coherent reflections often greatly exceeds that of incoherent broadband emissions arising from inertial cavitation and the ability to distinguish these two components is, thus, key to successful detection and mapping of inertial cavitation. We propose a novel time-domain-based filter that uses a parametric model in order to estimate a time-varying amplitude harmonic component in the presence of a lower-amplitude broadband signal. Performance evaluation on simulated and experimental data has shown that the model is able to accurately detect a time-varying amplitude harmonic signal for harmonic-to-broadband amplitude ratio as high as 20 dB, even in short data lengths, decreasing the estimation error by at least 80% compared to conventional comb filtering, and it yields passive acoustic maps of better accuracy and spatial resolution. Sum-of-harmonics is expected to become a valuable component of real-time PAM and significantly contribute toward its clinical adoption.
The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice (2003)

Adiponectin has recently been shown to be a promising candidate for the treatment of obesity-associated metabolic syndromes. Replenishment of recombinant adiponectin in mice can decrease hyperglycemia, reverse insulin resistance, and cause sustained weight loss without affecting food intake. Here we report its potential roles in alcoholic and nonalcoholic fatty liver diseases in mice. Circulating concentrations of adiponectin decreased significantly following chronic consumption of high-fat ethanol-containing food. Delivery of recombinant adiponectin into these mice dramatically alleviated hepatomegaly and steatosis (fatty liver) and also significantly attenuated inflammation and the elevated levels of serum alanine aminotransferase. These therapeutic effects resulted partly from the ability of adiponectin to increase carnitine palmitoyltransferase I activity and enhance hepatic fatty acid oxidation, while it decreased the activities of two key enzymes involved in fatty acid synthesis, including acetyl-CoA carboxylase and fatty acid synthase. Furthermore, adiponectin treatment could suppress the hepatic production of TNF-alpha and plasma concentrations of this proinflammatory cytokine. Adiponectin was also effective in ameliorating hepatomegaly, steatosis, and alanine aminotransferase abnormality associated with nonalcoholic obese, ob/ob mice. These results demonstrate a novel mechanism of adiponectin action and suggest a potential clinical application of adiponectin and its agonists in the treatment of liver diseases.
On-demand acoustic droplet splitting and steering in a disposable microfluidic chip (2017)

On-chip droplet splitting is one of the fundamental droplet-based microfluidic unit operations to control droplet volume after production and increase operational capability, flexibility, and throughput. Various droplet splitting methods have been proposed, and among them the acoustic droplet splitting method is promising because of its label-free operation without any physical or thermal damage to droplets. Previous acoustic droplet splitting methods faced several limitations: first, they employed a cross-type acoustofluidic device that precluded multichannel droplet splitting; second, they required irreversible bonding between a piezoelectric substrate and a microfluidic chip, such that the fluidic chip was not replaceable. Here, we present a parallel-type acoustofluidic device with a disposable microfluidic chip to address the limitations of previous acoustic droplet splitting devices. In the proposed device, an acoustic field is applied in the direction opposite to the flow direction to achieve multichannel droplet splitting and steering. A disposable polydimethylsiloxane microfluidic chip is employed in the developed device, thereby removing the need for permanent bonding and improving the flexibility of the droplet microfluidic device. We experimentally demonstrated on-demand acoustic droplet bi-splitting and steering with precise control over the droplet splitting ratio, and we investigated the underlying physical mechanisms of droplet splitting and steering based on Laplace pressure and ray acoustics analyses, respectively. We also demonstrated droplet tri-splitting to prove the feasibility of multichannel droplet splitting. The proposed on-demand acoustic droplet splitting device enables on-chip droplet volume control in various droplet-based microfluidic applications.
A novel structure of MOSFET array to measure ioff-ion with high accuracy and high density (2015)

We have successfully developed the new design of MOSFET array structure with high accuracy measurement both for Ion excluding IR drop and Ioff without contamination. We propose measurement algorithm “feedback looped biasing” with kelvin probe structure and canceling method for leakage contamination due to array peripherals. This test structure is implemented in scribe line for 28nm technology and beyond. And we get layout dependency of MOSFET characteristics and mismatch characteristics.
Protein Engineering of Toluene- o -Xylene Monooxygenase from Pseudomonas stutzeri OX1 for Synthesizing 4-Methylresorcinol, Methylhydroquinone, and Pyrogallol (2004)

Toluene-o-xylene monooxygenase (ToMO) from Pseudomonas stutzeri OX1 oxidizes toluene to 3- and 4-methylcatechol and oxidizes benzene to form phenol; in this study ToMO was found to also form catechol and 1,2,3-trihydroxybenzene (1,2,3-THB) from phenol. To synthesize novel dihydroxy and trihydroxy derivatives of benzene and toluene, DNA shuffling of the alpha-hydroxylase fragment of ToMO (TouA) and saturation mutagenesis of the TouA active site residues I100, Q141, T201, and F205 were used to generate random mutants. The mutants were initially identified by screening with a rapid agar plate assay and then were examined further by high-performance liquid chromatography and gas chromatography. Several regiospecific mutants with high rates of activity were identified; for example, Escherichia coli TG1/pBS(Kan)ToMO expressing the F205G TouA saturation mutagenesis variant formed 4-methylresorcinol (0.78 nmol/min/mg of protein), 3-methylcatechol (0.25 nmol/min/mg of protein), and methylhydroquinone (0.088 nmol/min/mg of protein) from o-cresol, whereas wild-type ToMO formed only 3-methylcatechol (1.1 nmol/min/mg of protein). From o-cresol, the I100Q saturation mutagenesis mutant and the M180T/E284G DNA shuffling mutant formed methylhydroquinone (0.50 and 0.19 nmol/min/mg of protein, respectively) and 3-methylcatechol (0.49 and 1.5 nmol/min/mg of protein, respectively). The F205G mutant formed catechol (0.52 nmol/min/mg of protein), resorcinol (0.090 nmol/min/mg of protein), and hydroquinone (0.070 nmol/min/mg of protein) from phenol, whereas wild-type ToMO formed only catechol (1.5 nmol/min/mg of protein). Both the I100Q mutant and the M180T/E284G mutant formed hydroquinone (1.2 and 0.040 nmol/min/mg of protein, respectively) and catechol (0.28 and 2.0 nmol/min/mg of protein, respectively) from phenol. Dihydroxybenzenes were further oxidized to trihydroxybenzenes with different regiospecificities; for example, the I100Q mutant formed 1,2,4-THB from catechol, whereas wild-type ToMO formed 1,2,3-THB (pyrogallol). Regiospecific oxidation of the natural substrate toluene was also checked; for example, the I100Q mutant formed 22% o-cresol, 44% m-cresol, and 34% p-cresol, whereas wild-type ToMO formed 32% o-cresol, 21% m-cresol, and 47% p-cresol.
A Combinatorial Library of Macrocyclic Polyamines Produced by a Ladybird Beetle (2000)

The pupal defensive secretion of the coccinellid beetle Epilachna borealis is composed principally of a combinatorial library of several hundred macrocyclic polyamines. This new family of natural products is characterized by extremely large-ring monocyclic polylactones, which are derived from the oligomerization of three homologous (ω-1)-(2-hydroxyethylamino)alkanoic acids. The characterization and quantification of these novel macrocyclic alkaloids as well as of related open-chain oligomers are described. Via HPLC-MS analyses of suitable derivatives, macrocycles with ring sizes from 24 to over 150 members were characterized. Whereas the three building blocks appear to be randomly incorporated into these oligomers, comparison with other ladybird beetle species suggests that the spectrum of ring sizes produced is carefully regulated.
Performance Analysis of A SLIPT-Based Hybrid VLC/RF System (2020)

To alleviate the energy constraint and coverage limitations in Internet of Things applications, in this paper we investigate a dual-hop hybrid visible light communication (VLC)/radio frequency (RF) cooperative communication system based on simultaneous lightwave information and power transfer. The proposed system consists of a light-emitting diode source (S), an off-the-grid relay (R) that moves randomly within the coverage of S, and a destination (D) that is located outside the coverage of S. To facilitate communications between S and D, the received optical signal at R in the first phase can be separated into alternating current and direct current components for information decoding and energy harvesting, respectively. Then the energy harvested by R is used to forward the decoded information to D using RF in the second phase. In view of the distinct channel conditions across the two hops, the decoding status and the energy available at R, the end-to-end system outage probability is analytically derived. Simulation results are used to evaluate the impact of different system parameters and demonstrate the efficiency of the proposed system.
ChemInform Abstract: An Efficient Large Scale Synthesis of Coumarins by a Dealkylative Boron‐Mediated Ring Closure of 3‐(ortho‐Methoxyaryl)propenoic Esters. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Using Back-Scattering Interferometry to Aid in Probe Development and Drug Efficacy Monitoring (2013)

The success of personalized or molecular medicine hinges on the availability of physiologically relevant patient bioinformatics, e.g. biomarker-based diagnostics, therapy selection and efficacy determination. To enable the effective collection of these biological metrics in the clinical setting, it will be necessary to quantify protein biomarkers in small amounts of serum, urine, or sputum and, in many cases, at femtomolar levels. Furthermore, it is desirable to determine the binding affinity, KD, and/or the relative biodistribution for a therapeutic in the target biological matrix. Since candidate molecular imaging agents have drug-like properties, needing to be delivered in a functional configuration and then bind to the target with high specificity, while not activating undesirable physiology, they can be studied similarly.