gebhart/patrepeval huggingface dataset:
Qos provisioning in wi-fi networks: capacity modeling and resource control (2005)

The ubiquitous Wireless Fidelity (Wi-Fi) networks, and their increasing quality of service (QoS) requirements for emerging applications, motivate extensive studies of QoS provisioning in such networks. Two tasks, namely, capacity modeling and resource control, are crucial in solving the problem:\n\nA performance model is first needed to predict the network QoS metrics from the network settings. We propose a new unified analytical model to study the saturation throughput and delay performance of 802.11e Enhanced Distributed Coordination Function (EDCA), which is easier to apply than the most current ones. In order to find usable mathematical models for most cases where analytical models are not feasible, we first advocate the application of metamodeling techniques to Wi-Fi performance studies and formulate a general metamodeling framework for such purpose. The results in three case studies support the validity of our methodology: our saturation capacity metamodel for 802.11 Distributed Coordination Function (DCF) displays an interesting log-linear relationship between capacity and number of users; our voice over Wi-Fi admission capacity metamodel gives a much tighter bound than bounds existing in the literature; and, finally, our throughput metamodel for a simple ad-hoc network, for the first time, characterizes the cross-layer effects between MAC and network layer. Our work, therefore, points out a new direction for future performance studies of Wi-Fi networks.\n\nThen, based on the performance models we derive, control schemes of input parameters can be designed to achieve certain level of QoS outputs in some cases. For example, we are able to design a Weighted Round Robin (WRR) scheduler at the MAC layer to control the share of the radio resources, by applying our analytical model to a special case of EDCA configuration. Furthermore, based on our fitted metamodel for the capacity of voice over Wi-Fi, a more practical admission control scheme is composed.
A three-port Photovoltaic (PV) micro-inverter with power decoupling capability (2011)

This paper presents a new micro-inverter topology that is intended for single-phase grid-connected PV systems. The features of the proposed topology are: (1) eliminating the double-frequency power ripple using small film capacitor; (2) improving the maximum-power-point tracking (MPPT) performance; (3) using long life-time film capacitors, which will improve the reliability of the inverter; and (4) requiring no additional circuitry to manage the transformer leakage energy.
Symposium on Public Policy Issues in Finance (1997)

ABSTRACT The thesis of this symposium, organized by James Bicksler, was that while finance theory will surely inform practitioners, it seems appropriate to pay some attention to the opposite flow: practitioners can inform theory. Contributors include a distinguished group of practitioners with extensive backgrounds in economics, and economists with extensive public policy experience: Martin Feldstein, Robert Glauber, David Mullins, and Steven Wallman. Their topics range from privatizing social security, to managing market crashes, to the regulatory agency cost problem, to regulatory constraints in a technologically advanced world.
Supplementary Table 3 from <i>Pten</i> Inactivation Accelerates Oncogenic <i>K-ras</i>–Initiated Tumorigenesis in a Mouse Model of Lung Cancer (2023)

Supplementary Table 3 from &lt;i&gt;Pten&lt;/i&gt; Inactivation Accelerates Oncogenic &lt;i&gt;K-ras&lt;/i&gt;–Initiated Tumorigenesis in a Mouse Model of Lung Cancer
Long-Term Channel Information-Based CoMP Beamforming in LTE-Advanced Systems (2011)

Coordinated multi-point (CoMP) transmission and reception is a network multiple-input multiple- output (MIMO) technology considered in 3GPP LTE- Advanced systems. In order to improve reliability and capacity of the services for the user equipments (UEs) at the cell edges, CoMP utilizes cooperation among neighboring enhanced node Bs (eNBs). Accordingly, backhaul delay for sharing control signals among eNBs should be carefully handled as UE mobility increases in a fading channel environment; otherwise, CoMP operations derived from inaccurate channel state information (CSI) of neighboring eNBs can severely degrade the system performance. We propose CoMP beamforming schemes using long-term CSI such as spatial correlation matrices instead of instantaneous CSI of neighboring cells. Since long- term CSI varies relatively slowly, the proposed scheme is inherently robust even when a UE moves at a high speed and/or the backhaul delay is large. Using a multi-cell simulator which reflects realistic CoMP system environments, the performance gain of the proposed schemes is evaluated and discussed.
Lattice Partition Multiple Access: A New Method of Downlink Non-Orthogonal Multiuser Transmissions (2016)

In this paper, we propose a new downlink non-orthogonal multiuser superposition transmission scheme for future 5G cellular networks, which we refer to as the lattice partition multiple access (LPMA). In this proposed design, the base station transmits multilevel lattice codes for multiple users. Each user's code level corresponds to a distinct prime and is weighted by a product of all distinct primes of the other users excluding its own. Due to the structural property of lattice codes, each user can cancel out the interference from the other code levels by using the modulo lattice operation in a successive/parallel manner. LPMA can provide better user fairness in symmctrical broadcast channels, compared with non- orthogonal multiple access (NOMA). We demonstrate that the proposed LPMA shows a clear throughput enhancement over the current NOMA scheme.
Automated method for iterative optimization of macromolecular crystallization screens (2017)

Major technological advances have increased the throughput of macromolecular crystallography, however, in many cases the identification of favorable crystallization conditions remains the rate-limiting step. Here, we present an automated method for the optimization of crystallization screens that iteratively adjusts precipitant concentrations based on the results of previous crystallization trials. In this Iterative Screen Optimization (ISO) method, the outcome of each crystallization experiment is visualized and manually scored using the program RockMaker. The scores are then used to generate a new crystallization screen by adjusting the precipitant concentrations of each reservoir solution to achieve a metastable macromolecular solution that favors crystal nucleation and growth. To facilitate the application of this method, we designed a crystallization screen comprising fifteen stock solutions of commercially available reagents that could be iteratively optimized using a Formulator liquid-handling device. We then assessed this screen and the ISO method on a set of six proteins that included several wellestablished crystallization standards. For all proteins evaluated, successive rounds of optimization produced a substantial increase in the number of crystallization hits. These results demonstrate that the ISO method is an efficient approach to maximizing the probability of obtaining crystals of a macromolecule from a limited set of reagents.
Data from A Squalene-Based Nanomedicine for Oral Treatment of Colon Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;Nanotechnology offers many possibilities to improve drug treatments, including with regard to drug pharmacology. The current study reports a simple approach to improve cisplatin efficacy in the treatment of colon cancer through the creation of orally administered squalenoylated nanoparticles loaded with cisplatin (SQ-CDDP NP). Cytotoxic effects of SQ-CDDP NP were assessed in human colonic cells and in mouse models of intestinal cancer. In cell culture, SQ-CDDP NP exhibited at least 10-fold greater cytotoxic potency compared with uncomplexed cisplatin, reflecting an enhancement in intracellular accumulation and DNA platination. Mechanistic investigations showed that SQ-CDDP NP stimulated ROS production, expression of heavy metal–inducible and stress-inducible genes, stress kinase cascades, and apoptosis. In Apc&lt;sup&gt;Min/+&lt;/sup&gt; mice, a model of intestinal tumorigenesis, oral administration of SQ-CDDP NP curtailed spontaneous tumor formation and azoxymethane-induced colon carcinogenesis with no apparent evidence of tissue toxicity. Our results offer preclinical validation of a nanocarrier formulation that can safely improve chemotherapeutic efficacy, address risks of drug resistance, and improve patient compliance by enabling oral administration. &lt;i&gt;Cancer Res; 77(11); 2964–75. ©2017 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Investigation on Cell Selection Methods Associated with Inter-cell Interference Coordination in Heterogeneous Networks for LTE-Advanced Downlink (2011)

In LTE-Advanced, a heterogeneous network where femtocells and picocells overlaid onto macrocells is extensively discussed in addition to traditional well-planned macrocell deployment to improve further the system throughput. In heterogeneous network deployment, cell selection as well as intercell interference coordination (ICIC) is very important to improve the system and cell-edge throughput. Therefore, this paper investigates three cell selection methods associated with ICIC in heterogeneous networks in the LTE-Advanced downlink: signal-to-interference plus noise power ratio (SINR)-based cell selection, reference signal received power (RSRP)-based cell selection, and reference signal received quality (RSRQ)-based cell selection. Simulation results (4 pico eNodeBs and 25 set of user equipment are uniformly located within 1 macro eNodeB) assuming full buffer model show that the downlink cell and cell-edge user throughput levels of RSRP-based cell selection are degraded by approximately 3% and 10% compared to those of SINR-based cell selection under the condition of the maximizing the cell-edge user throughput due to the impairment of the interference level. Furthermore, it is shown that the downlink cell-edge user throughput of RSRQ-based cell selection is improved approximately 5%, although the cell throughput is degraded approximately 5% compared to that for SINR-based cell selection under the condition of the maximizing the cell-edge user throughput.
TCAD-Based Predictive NBTI Framework for Sub-20-nm Node Device Design Considerations (2016)

The kinetics of trap generation during negative-bias temperature instability (NBTI) stress in pMOSFETs, as governed by the double interface H-H2 reaction-diffusion (RD) model, is incorporated for the first time in a commercial technology computer-aided design (TCAD) software, and used for simulating degradation in various device architectures. The calibrated TCAD framework is shown to successfully explain the measured impact of interface trap generation (ΔNIT) in bulk silicon FinFETs for wide range of stress bias and temperature. The impact of device design on NBTI degradation is explored by comparing the simulated trap generation kinetics in bulk FinFET, silicon on insulator FinFET, and gate all around nanowire FET devices having different geometries. The simulated predictions agree well with the experimental observations reported in the literature. The proposed TCAD framework would enable performance-reliability co-optimization during device design for advanced technology nodes.
Visualizing the problems with the INEX topics (2009)

Topics form a crucial component of a test collection. We show, through visualization, that the INEX 2008 topics have shortcomings, which questions their validity for evaluating XML retrieval effectiveness.
Circular RNAs are depleted of polymorphisms at microRNA binding sites (2014)

Using SNP data from the 1000 Genomes Project, we found a significant decrease in SNP density at miRNA seed sites compared with flanking sequences and random sites. This decrease was similar to that of miRNA seed sites in 3' untranslated regions, suggesting that many of the predicted miRNA binding sites in circRNAs are functional and under similar selective pressure as miRNA binding sites in mRNAs.
ChemInform Abstract: A New Sequence for the Cα‐Alkylation of 4,5‐Dihydroimidazoles. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Simplified spectropolarimetry using reactive mesogen polarization gratings (2006)

The measurement of complete polarimetric parameters for a broad spectrum of wavelengths is challenging because of the multi-dimensional nature of the data and the need to chromatically separate the light under test. As a result, current methods for spectropolarimetry and imaging polarimetry are limited because they tend to be complex and/or relatively slow. Here we experimentally demonstrate an approach to measure all four Stokes parameters using three polarization gratings and four simultaneous intensity measurements, with potential to dramatically impact the varied fields of air/space-borne remote sensing, target detection, biomedical imaging/diagnosis, and telecommunications. We have developed reactive mesogen polarization gratings using simple spin-casting and holography techniques, and used them to implement a potentially revolutionary detector capable of simultaneous measurement of full polarization information at many wavelengths with no moving or tunable elements. This polarimeter design not only enables measurements over a likely bandwidth of up to 70% of the center wavelength, it is also capable of measurements at relatively high speed (MHz or more) limited only by the choice of photo-detectors and processing power of the system. The polarization gratings themselves manifest nearly ideal behavior, including diffraction efficiencies of greater than 99%, strong polarization sensitivity of the first diffraction orders, very low incoherent scattering, and suitability for visible and infrared light. Due to its simple and compact design, simultaneous measurement process, and potential for preserving image registration, this spectropolarimeter should prove an attractive alternative to current polarization detection and imaging systems.
Regioselective Synthesis of Benzimidazolones via Cascade C–N Coupling of Monosubstituted Ureas (2014)

A direct method for the regioselective construction of benzimidazolones is reported wherein a single palladium catalyst is employed to couple monosubstituted urea substrates with differentially substituted 1,2-dihaloaromatic systems. In this method, the catalyst is able to promote a cascade of two discrete chemoselective C–N bond-forming processes that allows the highly selective and predictable formation of complex heterocycles from simple, readily available starting materials.
Polymer adhesion in heat‐treated nonwovens (2017)

ABSTRACT Polymer adhesion and sintering in compound nonwovens was studied. Nonwovens containing a mixture of binding bi‐component (BICO) fibers embedded in a fibrous matrix were heated to melt the outer shell of BICO fibers and interlock the matrix to create stiff load‐bearing surfaces. It was found that stiffness depends on heat‐treatment regimes. In low‐temperature regimes, BICO fibers melt, but do not fully flow and encase the surrounding filler matrix. At sufficiently high temperatures, the shells of BICO fibers melt and flow which results in encasing the neighboring filler fibers. This results in an abrupt increase in the nonwoven stiffness which is independent of heat‐treatment temperature. At significantly high temperatures, the filler matrix fibers sinter to each other leading to a further increase in stiffness. The experiments were conducted with co‐polymers frequently used in the shells of BICO to demonstrate the interlocking mechanism characteristic of these compound nonwovens. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018 , 135 , 46165.
Direct numerical simulation of the turbulent boundary layer over a cube-roughened wall (2011)

Direct numerical simulation (DNS) of a spatially developing turbulent boundary layer (TBL) over a wall roughened with regularly arrayed cubes was performed to investigate the effects of three-dimensional (3-D) surface elements on the properties of the TBL. The cubes were staggered in the downstream direction and periodically arranged in the streamwise and spanwise directions with pitches of p x / k = 8 and p z / k = 2, where p x and p z are the streamwise and spanwise spacings of the cubes and k is the roughness height. The Reynolds number based on the momentum thickness was varied in the range Re θ = 300−1300, and the roughness height was k = 1.5θ in , where θ in is the momentum thickness at the inlet, which corresponds to k /δ = 0.052–0.174 from the inlet to the outlet; δ is the boundary layer thickness. The characteristics of the TBL over the 3-D cube-roughened wall were compared with the results from a DNS of the TBL over a two-dimensional (2-D) rod-roughened wall. The introduction of cube roughness affected the turbulent Reynolds stresses not only in the roughness sublayer but also in the outer layer. The present instantaneous flow field and linear stochastic estimations of the conditional averaging showed that the streaky structures in the near-wall region and the low-momentum regions and hairpin packets in the outer layer are dominant features in the TBLs over the 2-D and 3-D rough walls and that these features are significantly affected by the surface roughness throughout the entire boundary layer. In the outer layer, however, it was shown that the large-scale structures over the 2-D and 3-D roughened walls have similar characteristics, which indicates that the dimensional difference between the surfaces with 2-D and 3-D roughness has a negligible effect on the turbulence statistics and coherent structures of the TBLs.
Partial Characterization of the Cytoplasmic Domain of Human Kidney Band 3 (1995)

The major anion exchanger in type A intercalated cells of the cortical and medullary collecting ducts of the human kidney is a truncated isoform of erythrocyte band 3 (AE1) that lacks the N-terminal 65 residues. Because this missing sequence has been implicated in the binding of ankyrin, protein 4.1, several glycolytic enzymes, hemoglobin, and hemichromes in erythrocytes, we have undertaken examination of the structure and peripheral protein interactions of this kidney isoform. The cytoplasmic domain of kidney band 3, kidney CDB3, was expressed in Escherichia coli and purified to homogeneity. The kidney isoform exhibited a circular dichroism spectrum and Stokes radius similar to its larger erythrocyte counterpart. Kidney CDB3 was also observed to engage in the same conformational equilibrium characteristic of erythrocyte CDB3. In contrast, the tryptophan and cysteine clusters of kidney CDB3 behaved very differently from erythrocyte CDB3 in response to pH changes and oxidizing conditions. Furthermore, kidney CDB3 did not bind ankyrin, protein 4.1, or aldolase, and expression of erythrocyte CDB3 was toxic to its bacterial host, whereas expression of kidney CDB3 was not. Taken together, these data suggest that the absence of the N-terminal 65 amino acids in kidney CDB3 eliminates the major function currently ascribed to CDB3 in erythrocytes, i.e. that of peripheral protein binding. The primary function of residues 66-379 found in kidney CDB3 thus remains to be elucidated.
The site of allergen expression in hematopoietic cells determines the degree and quality of tolerance induced through molecular chimerism (2013)

The transplantation of allergens (e.g. Phl p 5 or Bet v 1) expressed on BM cells as membrane-anchored full-length proteins leads to permanent tolerance at the T-cell, B-cell, and effector-cell levels. Since the exposure of complete allergens bears the risk of inducing anaphylaxis, we investigated here whether expression of Phl p 5 in the cytoplasm (rather than on the cell surface) is sufficient for tolerance induction. Transplantation of BALB/c BM retrovirally transduced to express Phl p 5 in the cytoplasm led to stable and durable molecular chimerism in syngeneic recipients (∼20% chimerism at 6 months). Chimeras showed allergen-specific T-cell hyporesponsiveness. Further, Phl p 5-specific TH 1-dependent humoral responses were tolerized in several chimeras. Surprisingly, Phl p 5-specific IgE and IgG1 levels were significantly reduced but still detectable in sera of chimeric mice, indicating incomplete B-cell tolerance. No Phl p 5-specific sIgM developed in cytoplasmic chimeras, which is in marked contrast to mice transplanted with BM expressing membrane-anchored Phl p 5. Thus, the expression site of the allergen substantially influences the degree and quality of tolerance achieved with molecular chimerism in IgE-mediated allergy.
Minimal In Vivo Efficacy of Iminosugars in a Lethal Ebola Virus Guinea Pig Model (2016)

The antiviral properties of iminosugars have been reported previously in vitro and in small animal models against Ebola virus (EBOV); however, their effects have not been tested in larger animal models such as guinea pigs. We tested the iminosugars N-butyl-deoxynojirimycin (NB-DNJ) and N-(9-methoxynonyl)-1deoxynojirimycin (MON-DNJ) for safety in uninfected animals, and for antiviral efficacy in animals infected with a lethal dose of guinea pig adapted EBOV. 1850 mg/kg/day NB-DNJ and 120 mg/kg/day MON-DNJ administered intravenously, three times daily, caused no adverse effects and were well tolerated. A pilot study treating infected animals three times within an 8 hour period was promising with 1 of 4 infected NB-DNJ treated animals surviving and the remaining three showing improved clinical signs. MON-DNJ showed no protective effects when EBOV-infected guinea pigs were treated. On histopathological examination, animals treated with NB-DNJ had reduced lesion severity in liver and spleen. However, a second study, in which NB-DNJ was administered at equally-spaced 8 hour intervals, could not confirm drug-associated benefits. Neither was any antiviral effect of iminosugars detected in an EBOV glycoprotein pseudotyped virus assay. Overall, this study provides evidence that NB-DNJ and MON-DNJ do not protect guinea pigs from a lethal EBOV-infection at the dose levels and regimens tested. However, the one surviving animal and signs of improvements in three animals of the NB-DNJ treated cohort could indicate that NB-DNJ at these levels may have a marginal beneficial effect. Future work could be focused on the development of more potent iminosugars.
Ogt-Dependent X-Chromosome-Linked Protein Glycosylation Is a Requisite Modification in Somatic Cell Function and Embryo Viability (2004)

The Ogt gene encodes a glycosyltransferase that links N-acetylglucosamine to serine and threonine residues (O-GlcNAc) on nuclear and cytosolic proteins. Efforts to study a mammalian model of Ogt deficiency have been hindered by the requirement for this X-linked gene in embryonic stem cell viability, necessitating the use of conditional mutagenesis in vivo. We have extended these observations by segregating Ogt mutation to distinct somatic cell types, including neurons, thymocytes, and fibroblasts, the latter by an approach developed for inducible Ogt mutagenesis. We show that Ogt mutation results in the loss of O-GlcNAc and causes T-cell apoptosis, neuronal tau hyperphosphorylation, and fibroblast growth arrest with altered expression of c-Fos, c-Jun, c-Myc, Sp1, and p27. We further segregated the mutant Ogt allele to parental gametes by oocyte- and spermatid-specific Cre-loxP mutagenesis. By this we established an in vivo genetic approach that supports the ontogeny of female heterozygotes bearing mutant X-linked genes required during embryogenesis. Successful production and characterization of such female heterozygotes further indicates that mammalian cells commonly require a functional Ogt allele. We find that O-GlcNAc modulates protein phosphorylation and expression among essential and conserved cell signaling pathways.