gebhart/patrepeval huggingface dataset:
Deep Venomics Reveals the Mechanism for Expanded Peptide Diversity in Cone Snail Venom (2012)

Cone snails produce highly complex venom comprising mostly small biologically active peptides known as conotoxins or conopeptides. Early estimates that suggested 50-200 venom peptides are produced per species have been recently increased at least 10-fold using advanced mass spectrometry. To uncover the mechanism(s) responsible for generating this impressive diversity, we used an integrated approach combining second-generation transcriptome sequencing with high sensitivity proteomics. From the venom gland transcriptome of Conus marmoreus, a total of 105 conopeptide precursor sequences from 13 gene superfamilies were identified. Over 60% of these precursors belonged to the three gene superfamilies O1, T, and M, consistent with their high levels of expression, which suggests these conotoxins play an important role in prey capture and/or defense. Seven gene superfamilies not previously identified in C. marmoreus, including five novel superfamilies, were also discovered. To confirm the expression of toxins identified at the transcript level, the injected venom of C. marmoreus was comprehensively analyzed by mass spectrometry, revealing 2710 and 3172 peptides using MALDI and ESI-MS, respectively, and 6254 peptides using an ESI-MS TripleTOF 5600 instrument. All conopeptides derived from transcriptomic sequences could be matched to masses obtained on the TripleTOF within 100 ppm accuracy, with 66 (63%) providing MS/MS coverage that unambiguously confirmed these matches. Comprehensive integration of transcriptomic and proteomic data revealed for the first time that the vast majority of the conopeptide diversity arises from a more limited set of genes through a process of variable peptide processing, which generates conopeptides with alternative cleavage sites, heterogeneous post-translational modifications, and highly variable N- and C-terminal truncations. Variable peptide processing is expected to contribute to the evolution of venoms, and explains how a limited set of ∼ 100 gene transcripts can generate thousands of conopeptides in a single species of cone snail.
miR-31 and its host gene lncRNA LOC554202 are regulated by promoter hypermethylation in triple-negative breast cancer (2012)

Loss of miR-31 expression in TNBC cell lines is attributed to hypermethylation of its promoter-associated CpG island. Together, our results provide the initial evidence for a mechanism by which miR-31, an important determinant of the invasion metastasis cascade, is regulated in breast cancer.
Serum lipid antibodies are associated with cerebral tissue damage in multiple sclerosis (2016)

We propose serum antibody repertoires that are associated with MRI measures of cerebral MS involvement. Such antibodies may serve as biomarkers for monitoring disease pathology and progression.
Untersuchung des Effekts von Patientenbewegung auf die 3D Dosimetrie für die Lu-177-PSMA Therapie mittels Siemens xSPECT Quant mit integrierter Bewegungskorrektur sowie Siemens Dosimetry Research Tool (2019)

Die 3D Dosimetrie kann wichtige Aspekte bei der Beurteilung des Ansprechens in der Radionuklidtherapie liefern, eine Automatisierung ist jedoch Bedingung für die klinische Anwendbarkeit. Die SPECT Bildgebung bei der Lu-177-PSMA Therapie ist durch den schlechten Allgemeinzustand der mCRPC-Patienten (Schmerzen) meist nicht bewegungsfrei möglich. Der Effekt von Schmerz-induzierten Bewegungen auf die SPECT und automatisierte 3D Dosimetrie soll mittels Siemens Dosimetry Research Tool (DRT) untersucht werden, sowie das Potential einer Bewegungskorrektur (BK) innerhalb der Rekonstruktion (Siemens xSPECT Quant).
Role of AuxPt1–x Clusters in the Enhancement of the Electrochemical Activity of ZnO Nanorod Electrodes (2017)

This study quantitatively elucidates the role of metal clusters in the electrochemical activation of metal-oxide nanostructured electrodes. Through the deposition of nearly monodisperse AuxPt1–x (x = 0, 0.5, 1) clusters, smaller than 3 nm, on the ZnO nanorod (NR) electrode surface, a controlled enhancement of charge transfer and activation of electrocatalytic processes was achieved. The interfacial electrical states of the hybrid electrodes were probed by electrochemical impedance spectroscopy (EIS). Analysis of the charge-transfer resistance and interface capacitance, estimated by modeling EIS curves in different bias regimes, indicated the presence of a large amount of active donor states (∼1020 cm–3) at the surface of the ZnO NRs. Decoration of the ZnO NRs with AuxPt1–x clusters strongly increased the charge-transfer process at the cluster–ZnO/electrolyte interface. This induced a more effective depletion of the electron charge available in the donor states of the ZnO NRs, leading to the formation of a positively charged layer at the interface between ZnO and the clusters. These two effects, intrinsically linked with the alignment between the electronic states of the AuxPt1–x clusters and ZnO, strongly enhance the interface reactivity of the ZnO NR electrodes toward the redox reaction of potassium ferricyanide. This is particularly relevant for understanding and improving the performance of electrochemical biosensors.
Transient spectroscopy of the lowest excited states of binuclear rhodium(I) isocyanides (1986)

The binuclear complexes Rh2b42+ (b = 1,3-diisocyanopropane) and Rh2(TMB)42+ (TMB = 2,5-dimethyl-2,5-diisocyanohexane) both exhibit absorption from their lowest excited singlet state (1A2u) and their lowest triplet state (3A2u). The excited-triplet-state absorption spectra are similar for the two complexes, with strong bands at 420 and 470 nm in Rh2b42+ and at 400 and 490 nm in Rh2(TMB)42+. The two bands are oppositely polarized (x-y, 420 and 400 nm; z, 470 and 490 nm) and are assigned to dπ → pσ (1eu → 2a1g) and dσ → dσ* (1a1g → 1a2u) transitions, respectively. Both complexes have weak, structureless absorptions in the red (λ > 600 nm) that are attributed to pσ → dδ (2a1g → dx2-y2) transitions. The excited singlet spectrum of each complex exhibits a strong band in the blue (450 nm, Rh2b42+; 440 nm, Rh2(TMB)42+) that is primarily z-polarized in Rh2(TMB)42+ and is assigned to dσ* → pσ (1a2u → 2a1g). © 1986 American Chemical Society.
Net-zero emissions energy systems (2019)

Some parts of the energy system are particularly difficult to decarbonize, including aviation, long-distance transport, steel and cement production, and provision of a reliable electricity supply. Current technologies and pathways show promise, but integration of now-discrete energy sectors and industrial processes is vital to achieve minimal emissions. Colors indicate the dominant role of specific technologies and processes. Green, electricity generation and transmission; blue, hydrogen production and transport; purple, hydrocarbon production and transport; orange, ammonia production and transport; red, carbon management; and black, end uses of energy and materials.
Overlay metrology performance prediction fidelity: the factors enabling a successful target design cycle (2016)

Overlay metrology performances highly depend on the detailed design of the measured target. Hence performing simulations is an essential tool for optimizing target design. We demonstrate for scatterometry overlay (SCOL) three key factors which enable consistency in ranking between simulated and measured metrology performance for target design. The first factor, to enable high fidelity simulations for the purpose of target design, is stack and topography verification of model inputs. We report in detail the best known film metrology methods required to achieve model integrity. The second factor is the method of calculation of metrology performance metrics based on target cell reflectivities from electro-magnetic (EM) simulations. These metrics enable ranking of different designs, and subsequent choice of the best performing designs among all simulated design options, the ranking methodology being the third factor. We apply the above steps to a specific stack, where five different designs have been considered. Simulated versus measured values are compared. A good agreement between simulation and measurement is achieved.
Pharmacy study of natural health product adverse reactions (SONAR): a cross-sectional study using active surveillance in community pharmacies to detect adverse events associated with natural health products and assess causality (2014)

A substantial proportion of community pharmacy patients use prescription drugs and NHPs concurrently; these patients are at a greater risk of experiencing an AE. Active surveillance provides a means of detecting such AEs and collecting high-quality data on which causality assessment can be based.
Structure of Shear-Induced Perforated Layer Phase in Styrene−Isoprene Diblock Copolymer Melts (2000)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTStructure of Shear-Induced Perforated Layer Phase in Styrene−Isoprene Diblock Copolymer MeltsJong-Hyun Ahn and Wang-Cheol ZinView Author Information Department of Materials Science & Engineering and Polymer Research Institute, Pohang University of Science and Technology, Pohang, Kyungbuk, 790-784, Korea Cite this: Macromolecules 2000, 33, 2, 641–644Publication Date (Web):January 6, 2000Publication History Received2 August 1999Revised15 November 1999Published online6 January 2000Published inissue 1 January 2000https://pubs.acs.org/doi/10.1021/ma9912812https://doi.org/10.1021/ma9912812brief-reportACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views942Altmetric-Citations63LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Chemical structure,Copolymers,Layers,Phase transitions,X-ray scattering Get e-Alerts
Successive-Cancellation Decoding of Reed-Muller Codes With Fast Hadamard Transform (2022)

A novel permuted fast successive-cancellation list decoding algorithm with fast Hadamard transform (FHT-FSCL) is presented. The proposed decoder initializes <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex-math notation="LaTeX">$L$</tex-math></inline-formula> <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex-math notation="LaTeX">$(L\geq 1)$</tex-math></inline-formula> active decoding paths with <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex-math notation="LaTeX">$L$</tex-math></inline-formula> random codeword permutations sampled from the full symmetry group of the codes. The path extension in the permutation domain is carried out until the first constituent RM code of order 1 is visited. Conventional path extension of the successive-cancellation list decoder is then utilized in the information bit domain. The simulation results show that for a RM code of length 512 with 46 information bits, by running 20 parallel permuted FHT-FSCL decoders with <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex-math notation="LaTeX">$L=4$</tex-math></inline-formula> , we reduce 72% of the computational complexity, 22% of the decoding latency, and 84% of the memory consumption of the state-of-the-art simplified successive-cancellation decoder that uses 512 permutations sampled from the full symmetry group of the code, with similar error-correction performance at the target frame error rate of <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex-math notation="LaTeX">$10^{-4}$</tex-math></inline-formula> .
Bandwidth as a function of number of sources and loads in multiport radio-frequency systems (2016)

We show how the bandwidth over which power can be transferred from multiple radio-frequency sources to multiple loads scales with the number of sources and loads. Our principal tools include broadband multiport matching upper bounds on the integral over all frequency of the logarithm of a suitably defined power reflection ratio. We also characterize matching structures whose bandwidth scale as the ratio between the numbers of loads and sources.
Multi-University Southeast INIE Consortium (2010)

2 Project Summary: The Multi-University Southeast INIE Consortium (MUSIC) was established in response to the US Department of Energy’s (DOE) Innovations in Nuclear Infrastructure and Education (INIE) program. MUSIC was established as a consortium composed of academic members and national laboratory partners. The members of MUSIC are the nuclear engineering programs and research reactors of Georgia Institute of Technology (GIT), North Carolina State University (NCSU), University of Maryland (UMD), University of South Carolina (USC), and University of Tennessee (UTK). The University of Florida (UF), and South Carolina State University (SCSU) were added to the MUSIC membership in the second year. In addition, to ensure proper coordination between the academic community and the nation’s premier research and development centers in the fields of nuclear science and engineering, MUSIC created strategic partnerships with Oak Ridge National Laboratory (ORNL) including the Spallation Neutron Source (SNS) project and the Joint Institute for Neutron Scattering (JINS), and the National Institute of Standards and Technology (NIST). A partnership was also created with the Armed Forces Radiobiology Research Institute (AFRRI) with the aim of utilizing their reactor in research if funding becomes available. Consequently, there are three university research reactors (URRs) within MUSIC, which are located at NCSU (1-MW PULSTAR), UMD (0.25-MW TRIGA) and UF (0.10-MW Argonaut), and the AFRRI reactor (1-MW TRIGA MARK F). The overall objectives of MUSIC are: a) Demonstrate that University Research Reactors (URR) can be used as modern and innovative instruments of research in the basic and applied sciences, which include applications in fundamental physics, materials science and engineering, nondestructive examination, elemental analysis, and contributions to research in the health and medical sciences, b) Establish a strong technical collaboration between the nuclear engineering faculty and the MUSIC URRs. This will be achieved by involving the faculty in the development of state-of-the-art research facilities at the URRs and subsequently, in the utilization of these facilities, c) Facilitate the use of the URRs by the science and engineering faculty within the individual institutions and by the general community of science and engineering, d) Develop a far-reaching educational component that is capable of addressing the needs of the nuclear science and engineering community. Specifically, the aim of this component will be to perform public outreach activities, contribute to the active recruitment of the next generation of nuclear professionals, strengthen the education of nuclear engineering students, and promote nuclear engineering education for minority students.
The Conversion of Benzyl Alcohols into Phenylacetic Acid Derivatives by Cobalt Carbonyl Catalyzed Carbonylation (1982)

Abstract Benzyl alcohols were converted into the corresponding one carbon-homologated amides or esters in one pot by cobalt carbonyl catalyzed carbonylation in the presence of ethyl polyphosphate (PPE) and sodium iodide.
Minimization of Carbon Monoxide Poisoning in Polymer Electrolyte Fuel Cells using in situ PROX Catalysts (2008)

The effects of a preferential oxidation (PROX) catalyst introduced inside a single cell PEFC are analyzed in this work. The purpose of introducing the PROX catalyst on the anode side is to create an environment conducive for the CO oxidation. The PROX catalyst investigated in this work is platinum on alumina that employs cobalt as a promoter. The PROX catalyst was introduced as a coating on the anode fuel flow channels and the change in cell performance was examined by comparing the polarization curves. Different concentrations of CO were fed to determine the CO tolerance of the cell in the presence of the PROX catalyst. The cell was also tested in the presence of the oxygen-bleed operation where oxygen was fed in front of the anode fuel stream. The results indicate an increase in the cell performance which is attributed to the presence of the PROX catalyst.
Immunodominant sites of human T cell lymphotropic virus type 1 envelope protein for murine helper T cells. (1989)

HTLV-I (human T cell lymphotropic virus type 1) is the retrovirus causally related to adult T cell leukemia/lymphoma and is also associated with a neurological disorder, tropical spastic paraparesis, or HTLV-I-associated myelopathy. The development of these two different diseases among HTLV-I-infected individuals may depend in part on differences in their T cell immunity associated with a difference of HLA phenotype. Peptides corresponding to 17 sites in the HTLV-I envelope protein were tested for their antigenicity for lymph node cells from B10.BR, B10.D2, B10.A(5R), and B10.HTT congenic mice, representing four independent MHC haplotypes, immunized with the native envelope protein. Ten of the 17 tested sites were predicted to be amphipathic alpha-helical sites and all of them were found to be antigenic for at least one of the four MHC congenic strains of mice. Three of the 17 sites were amphipathic 3(10)-helical sites and four sites were predicted to be non-helical sites: none of the 3(10)-helical sites were antigenic and only one of four non-predicted sites was found to be immunodominant. Furthermore, three potent immunodominant peptides, V1E1 (342-363), V1E8/SP4a (191-209), and V1E10 (141-156) were also shown to be immunogenic; i.e., these peptides could be used to immunize mice to elicit proliferative responses of lymph node cells to the native HTLV-I envelope protein. Furthermore, these three peptides were able to prime animals for an enhanced antibody response to the native protein. Because this priming followed the same Ir gene control as the proliferative response, it probably reflects the ability of these peptides to prime helper T cells. The localization of immunodominant sites in HTLV-I envelope protein in mice may be useful for finding antigenic and immunogenic sites in humans, for developing a peptide vaccine for the virus, and possibly for aiding in prognosis for the development of different disease manifestations of HTLV-I infection.
Clinical Usefulness of Electrophysiologic Testing in Patients with Ventricular Tachycardia and Chronic Chagasic Cardiomyopathy Treated with Amiodarone or Sotalol (2003)

In patients with chagasic cardiomyopathy and sustained VT, electrophysiologic testing can predict long-term efficacy of Class III antiarrhythmic drugs. This may help in the selection of patients for implantable cardioverter defibrillator therapy.
Supplementary Figure 3 from BET Bromodomain Inhibition of <i>MYC</i>-Amplified Medulloblastoma (2023)

&lt;p&gt;PDF file - 291K, Densitometry quantification of Western Immunoblots shown in Figures 4 and 5.&lt;/p&gt;
A prospective cohort study on the safety and efficacy of bevacizumab combined with chemotherapy in Japanese patients with relapsed ovarian, fallopian tube or primary peritoneal cancer (2020)

bevacizumab combined with chemotherapy was tolerable and effective for Japanese patients with relapsed ovarian cancer, fallopian tube cancer or primary peritoneal cancer. Hypertension and proteinuria are frequently occurred and managed properly for continuing treatment.
A comparison of the acceptance of immunochemical faecal occult blood test and colonoscopy in colorectal cancer screening: a prospective study among Chinese (2010)

Faecal occult blood test and direct colonoscopy were equally preferable to Chinese. Colonoscopy was preferred among the younger subjects, those with positive family history of CRC and self-perceived poor health status.
ChemInform Abstract: N‐Heterocyclic Carbene Catalyzed Homoenolate Addition to 3‐Methyl‐4‐nitro‐5‐styrylisoxazoles. (2012)

Abstract The title reaction yields functionalized cyclopentanones (III) as single diastereomers.
High Frequency (139.5 GHz) Electron Paramagnetic Resonance Spectroscopy of the GTP Form of p21 ras with Selective 17O Labeling of Threonine (1996)

Electron paramagnetic resonance spectroscopy at 139.5 GHz has been used to study p21 ras complexed with Mn(II) and guanosine 5'-(beta, gamma-imidotriphosphate), an analog of GTP. The p21 sample studied was selectively labeled with [17O gamma]threonine to a final enrichment of 30%. A Mn(II)-17O hyperfine interaction was observed, but the value of the coupling constant, 0.11 +/- 0.04 mT, is the smallest such value yet reported. Ab initio calculations indicate that this value is consistent with direct coordination of the threonine hydroxyl group and provide an estimate for the Mn(II)-17O bond length of 2.7 A. The measured hyperfine coupling constant and associated bond length starkly contrast with typical values for Mn(II)-17O coordination complexes, namely, approximately 0.25 mT and approximately 2.2 A, respectively. This contrast underscores the peculiar weakness of this Mn(II)-O interaction in p21 and persuasively argues that the nucleotide-induced conformational change, which is known to encompass the region of p21 involving Thr35, is not driven by Mn(II) coordination of the Thr35 hydroxyl group.
Integrated electron devices in medicine (1977)

Due to their revolutionary rate of advance for nearly two decades, integrated electron devices can be applied in medical instruments with outstanding advantages to the quality and availability of health care. To provide an overview of activities in this field, various types of medical electronic instruments are classified in a matrix format according to their orientation relative to the patient and the generic function which they perform. Explicit examples which illustrate the utility of custom integrated electron devices are: i) totally implantable blood flow telemetry for use in research animals, ii) noninvasive ultrasonic imaging systems for diagnostic and monitoring functions, and iii) a prosthetic optical-to-tactile reading aid for the blind.
Novel Pulse Electrodeposited Co–Cu–ZnO Nanowire/tube Catalysts for C1–C4Alcohols and C2–C6(Except C5) Hydrocarbons from CO and H2 (2012)

Co–Cu–ZnO nanowire/tube catalysts were synthesized using pulse electrodeposition technique from a single aqueous electrolyte solution using a template synthesis technique. They were then tested as catalysts for the hydrogenation of CO to alcohols and higher hydrocarbons. Nanowires/tubes were grown inside the pores of membranes using a three-step sequential deposition process. First, a low current of −6.9 mA/cm2 was applied for 300 ms for Cu deposition, then a high current density of −11.5 mA/cm2 for t ms (t = 500, 600, 750 ms) was applied for Co deposition, and finally no current was applied for 1200 ms so that the ions near the cathode replenish. The surface had a significantly different composition than the bulk. On the surface, there was more Co, less Cu, and more Zn. The catalyst showed the alcohol (C1–C4) selectivity of 20.9 %C at H2/CO = 3/1, GHSV = 16 000 scc/h gcat, temperature = 270 °C, pressure = 15 bar, and time-on-stream = 65 h.