gebhart/patrepeval huggingface dataset:
Highly Enantioselective Epoxidation of 1,1-Disubstituted Alkenes Catalyzed by Chloroperoxidase (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHighly Enantioselective Epoxidation of 1,1-Disubstituted Alkenes Catalyzed by ChloroperoxidaseAnnette F. Dexter, Frederick J. Lakner, Robert A. Campbell, and Lowell P. HagerCite this: J. Am. Chem. Soc. 1995, 117, 23, 6412–6413Publication Date (Print):June 1, 1995Publication History Published online1 May 2002Published inissue 1 June 1995https://pubs.acs.org/doi/10.1021/ja00128a053https://doi.org/10.1021/ja00128a053research-articleACS PublicationsRequest reuse permissionsArticle Views1088Altmetric-Citations121LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Direct Flow Medical percutaneous aortic valve: proof of concept (2008)

The Direct Flow Medical PAV is technically feasible and safe to deploy in humans with severe AS and results in a significant transaortic gradient reduction.
Constructing Category-Specific Models for Monocular Object-SLAM (2018)

We present a new paradigm for real-time object-oriented SLAM with a monocular camera. Contrary to previous approaches, that rely on object-level models, we construct category-level models from CAD collections which are now widely available. To alleviate the need for huge amounts of labeled data, we develop a rendering pipeline that enables synthesis of large datasets from a limited amount of manually labeled data. Using data thus synthesized, we learn category-level models for object deformations in 3D, as well as discriminative object features in 2D. These category models are instance-independent and aid in the design of object landmark observations that can be incorporated into a generic monocular SLAM framework. Where typical object-SLAM approaches usually solve only for object and camera poses, we also estimate object shape on-the-fty, allowing for a wide range of objects from the category to be present in the scene. Moreover, since our 2D object features are learned discriminatively, the proposed object-SLAM system succeeds in several scenarios where sparse feature-based monocular SLAM fails due to insufficient features or parallax. Also, the proposed category-models help in object instance retrieval, useful for Augmented Reality (AR) applications. We evaluate the proposed framework on multiple challenging real-world scenes and show - to the best of our knowledge - first results of an instance-independent monocular object-SLAM system and the benefits it enjoys over feature-based SLAM methods.
Understanding gaze and scrolling strategies in text consumption tasks (2015)

Scrolling is an integral part of our everyday computing experience, and many techniques and devices have been developed to enhance scrolling. We have conducted an 18 participant user study to understand how users' gaze position and scrolling strategies are coordinated. Our data showed that people scrolled within preferred reading regions of the screen. Scrolling patterns were also influenced by document structure, with most scrolling occurring at the intersection between paragraphs, in order to bring new text into the preferred reading region. We conclude with the implications of our findings with a new gaze-enhanced scrolling technique aimed to support behaviors evident in manual scrolling.
A complete UMTS transmitter using BAW filters and duplexer, a 90nm CMOS digital RF signal generator and a 0.25µm BiCMOS power amplifier (2011)

International audience
Endogenous rhythm generation in the pre‐Bötzinger complex and ionic currents: modelling and in vitro studies (2003)

The pre-Bötzinger complex is a small region in the mammalian brainstem involved in generation of the respiratory rhythm. As shown in vitro, this region, under certain conditions, can generate endogenous rhythmic bursting activity. Our investigation focused on the conditions that may induce this bursting behaviour. A computational model of a population of pacemaker neurons in the pre-Bötzinger complex was developed and analysed. Each neuron was modelled in the Hodgkin-Huxley style and included persistent sodium and delayed-rectifier potassium currents. We found that the firing behaviour of the model strongly depended on the expression of these currents. Specifically, bursting in the model could be induced by a suppression of delayed-rectifier potassium current (either directly or via an increase in extracellular potassium concentration, [K+]o) or by an augmentation of persistent sodium current. To test our modelling predictions, we recorded endogenous population activity of the pre-Bötzinger complex and activity of the hypoglossal (XII) nerve from in vitro transverse brainstem slices (700 micro m) of neonatal rats (P0-P4). Rhythmic activity was absent at 3 mm[K+]o but could be triggered by either the elevation of [K+]o to 5-7 mm or application of potassium current blockers (4-AP, 50-200 micro m, or TEA, 2 or 4 mm), or by blocking aerobic metabolism with NaCN (2 mm). This rhythmic activity could be abolished by the persistent sodium current blocker riluzole (25 or 50 micro m). These findings are discussed in the context of the role of endogenous bursting activity in the respiratory rhythm generation in vivo vs. in vitro and during normal breathing in vivo vs. gasping.
Abstract 4479: ONC201 is non-toxic at efficacious doses in vitro and in vivo (2015)

Abstract ONC201 is a small molecule that is entering clinical trials based on its favorable preclinical profile that includes robust anti-tumor activity in several preclinical models of advanced cancers. Despite inducing a strong cytotoxic response in tumor cells, ONC201 does not induce cell death in normal cells under the same conditions. In addition to a lack of cytoxicity towards normal cells, ONC201 also does not appear to be genotoxic based on gamma-H2AX assessment. Recent mechanistic studies have implicated the early stage induction of the ER stress response by ONC201, which includes induction of DR5 as part of its pro-apoptotic response. Biochemical studies reveal that ONC201 does not induce DR5 in normal cells at doses that cause strong DR5 induction in tumor cells. In accordance with in vitro profile, efficacious ONC201 dose schedules in murine models are also well tolerated without apparent alterations of normal tissue histology or significant loss of body weight. Similar observations were revealed in GLP toxicology studies in beagle dogs and Sprague-Dawley rats. Dogs received a single dose of 0, 4.2, 42, or 120 mg/kg by oral gavage, which represents a human equivalent of 0, 125 mg, 1.25 g, and 3.57 g, respectively. Rats received 0, 12.5, 125, or 225 mg/kg ONC201 by oral gavage, which represents a human equivalent of 0, 125 mg, 1.25 g, and 2.25 g, respectively. There were no deaths or dose-limiting toxicities. The only findings that were observed in both rats and dogs occurred at the highest doses tested and were mild and reversible: decreased activity (no indications of anemia), decreased food consumption (weight loss only seen in rats), and salivation. The NOAEL was at least 42 mg/kg in dogs and at least 125 mg/kg in rats. In summary, these in vitro and in vivo studies support that ONC201 has a large and favorable therapeutic index that is compelling given its powerful single agent anti-tumor efficacy. The coupling of the strong efficacy and safety profile of ONC201 is unique among cancer therapies and opens a broad range of clinical applications for its future development, including potential for combinatorial therapeutics. Citation Format: Joshua E. Allen, Wafik S. El-Deiry. ONC201 is non-toxic at efficacious doses in vitro and in vivo. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 4479. doi:10.1158/1538-7445.AM2015-4479
Selecting and Optimizing Origami Flasher Pattern Configurations for Finite-Thickness Deployable Space Arrays (2022)

Abstract Design parameters of the origami flasher pattern can be modified to meet a variety of design objectives for deployable array applications. The focus of this paper is to improve the understanding of design parameters, objectives, and trade-offs of origami flasher pattern configurations. Emphasis is placed on finite-thickness flasher models that would enable engineering applications. The methods presented aim to provide clarity on the effects of tuning flasher parameters based on existing synthesis tools. The results are demonstrated in the design of a flasher-based deployable LiDAR telescope where optimization is used to converge on optimal design parameters and the results are implemented in proof-of-concept hardware.
Development of a Surface Micromachined On-Chip Flat Disk Micropump (2009)

The paper presents research progress in the development of a surface micromachined flat disk micropump which employs the viscous and centrifugal effects acting on a layer of fluid sandwiched between a rotating flat disk and a stationary plate. The pump is fabricated monolithically on-chip using Sandia’s Ultraplanar Multilevel MEMS Technology (SUMMiT™) where an electrostatic comb-drive Torsional Ratcheting Actuator (TRA) drives the flat disk through a geared transmission. The paper reviews available analytical models for flow geometries similar to that of the described pump, and presents a set of experiments which depict its performance and possible failure modes. Those experiments highlight future research directions in the development of electrostatically-actuated, CMOS-compatible, surface micromachined pumps.
Psychometric properties of the Friedreich Ataxia Rating Scale (2019)

A correlation-based psychometric analysis of the neurologic FARSn score justifies the overall validity of the scale. In addition, omission of items of limited functional significance as created in the mFARS improves the features of the measures. Such information is crucial to the ongoing application of the mFARS in natural history studies and clinical trials. Additional analyses of longitudinal changes will be necessary to fully ascertain its utility, especially in nonambulant patients.
Barrier properties of surface sulfonated HDPE films (1995)

Abstract Films of high‐density polyethylene (HDPE) have been sulfonated by solid–gas phase reaction using gaseous sulfur trioxide (SO 3 ) of different concentrations in nitrogen. The effect of concentration of SO 3 in an SO 3 + N 2 gas mixture and time of sulfonation on solvent and gas barrier properties of sulfonated HDPE films was studied by determining toluene and oxygen permeability of HDPE films sulfonated with different concentrations of SO 3 for different times. The color developed in sulfonated HDPE films during sulfonation could be bleached by aqueous sodium hypochloride solution. The effect of sodium hypochloride solution treatment on oxygen permeability of sulfonated HDPE films was also studied. © 1995 John Wiley &amp; Sons, Inc.
Evolutionary Algorithms in the Presence of Noise: To Sample or Not to Sample (2007)

In this paper, we empirically analyze the convergence behavior of evolutionary algorithms (evolution strategies - ES and genetic algorithms A) for two noisy optimization problems which belong to the class of functions with noise induced multi-modality (FNIMs). Although, both functions are qualitatively very similar, the ES is only able to converge to the global optimizer state for one of them. Additionally, we observe that canonical GA exhibits similar problems. We present a theoretical analysis which explains the different behaviors for the two functions and which suggests to resort to resampling strategies to solve the problem. Although, resampling is an inefficient way to cope with noisy optimization problems, it turns out that depending on the properties of the problem, (moderate) resampling might be necessary to guarantee convergence to the robust optimizer
Impact of Rayleigh Backscattering on stimulated brillouin scattering threshold evaluation for 10Gb/s NRZ-OOK signals (2008)

We experimentally verified a decrease of stimulated Brillouin scattering threshold for 10 Gb/s NRZ-OOK signals with respect to theoretical predictions. We relate this reduction to Rayleigh backscattering interaction with Stokes backscattered spectrum. BER curves are shown.
A baseline Model for the Relationships between Network Operators and Tower Companies (2020)

The introduction of virtualization techniques in radio cellular networks allows the emergence of a business based on the outsourcing of towers hosting antennas and operated by the so-called Tower Companies (TowerCos). In this paper, we develop a baseline business model for studying the potential relationships between network operators and TowerCos. It turns out that the gain in operational costs achieved when network operators outsource the management of towers can be gracefully utilized to reduce prices so as to attract more customers. The price drop has however to be carefully realized so as not to break the market share between operators and to preserve competition. To prove this claim, we adopt in a first step a centralized optimization formulation. In a second step, we develop a game theoretic framework.
Challenges and controversies in the diagnosis of mesothelioma: Part 1. Cytology-only diagnosis, biopsies, immunohistochemistry, discrimination between mesothelioma and reactive mesothelial hyperplasia, and biomarkers (2013)

The detection of neoplastic invasion remains the linchpin for a clear diagnosis of malignant mesothelioma. Cytology-only diagnosis of epithelioid mesothelioma on aspirated effusion fluid remains controversial. A major problem is poor sensitivity, although cytodiagnosis is achievable in many cases at a high order of specificity, especially when a large volume of effusion fluid is submitted for cytological evaluation, enabling the preparation of cell-block sections for immunohistochemical investigation and when the cytological findings can be correlated with imaging studies to assess the anatomical distribution of the lesion and evidence of nodularity of the pleural disorder and, in some cases, to demonstrate evidence of invasion. Although 'positive' and 'negative' immunohistochemical markers have proved remarkably effective in distinguishing between epithelioid mesothelioma and secondary carcinoma and other malignant tumours metastatic to serosal membranes, no mesothelial marker has 100% sensitivity and specificity for mesothelioma diagnosis, so that panels of 'positive' antibodies and markers with negative predictive value are required. At present, no tissue or serum marker (including the molecular detection of p16/CDKN2A) has been proved to have sufficient specificity, consistency and reproducibility that it can replace evidence of invasion as the decisive marker for diagnosis when there is any uncertainty concerning a diagnosis of epithelioid mesothelioma and in the case of atypical fibrous lesions of the pleura (especially collagen-rich lesions, namely fibrous pleuritis vs desmoplastic mesothelioma), in which even the assessment of invasion can be problematical as illustrated in part 2 of this review.
An adaptive IIR pre-equalizer for terrestrial DTV transmitters (2005)

The work presents a novel pre-equalization method for terrestrial DTV transmitters. In the proposed pre-equalizer, an equation-error adaptive IIR filtering scheme is applied, unlike conventional pre-equalization using FIR filtering. The convergence performance, such as a residual MSE, is remarkably improved due to the pole-zero modeling property of IIR filters.
Analysis on Pad Surface Roughness of Diamond Conditioning Process for CMP (2021)

Chemical Mechanical Polishing/Planarization (CMP) is the key process of the wafer and thin film planarization process for semiconductor manufacturing. In the CMP process, the pad can restore its surface topography and efficiency by diamond conditioner or named as diamond conditioning process. The pad surface roughness is essential to the removal rate in the CMP process because it can represent the contact level of the polishing pad and wafer. This study has developed a simulation program based on precise diamond-grits conditioning routes and numbers of cross points. By studying the OP (overlap cutting points) distribution in a specific area on the pad which is generated by CL (cutting locus), the trend of roughness parameters is discovered. The simulation and experimental model can be effective to observe pores deformation and predict pad surface topography. The results show the pad roughness would become steady over a certain OP number, and the OP can be precisely calculated and compared to the actual pad surface. The final results of the break-in and pad conditioning process can be estimated or further optimized. The other high-density and customized diamond-grits arrangement of conditioner can be designed according to the study in future work.
Supplementary Figure 1C from NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis (2023)

Supplementary Figure 1C from NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis
Binding of Thyrotropin-Releasing Hormoi of Bovine Anterior Pituitary Gland (hormone receptor/adenylate cyclase/equilibrium constai (2016)

An assay for the binding of (3H)thyro- tropin-releasing hormone ((H)ITRH) is described. Plasma membranes isolated from bovine anterior pituitary gland bind about 600 femtomoles of this hormone per mg of protein, as compared to 15 femtomoles per mg of protein in the total adenohypophyseal homogenate (40-fold purification). The equilibrium constant of membrane receptor-(Hl)TRH binding at 0?C is 4.3 X 107 L-M-1, or a half-maximal binding of this hormone at 23 nM. The binding is time-dependent; addition of unlabeled hor- mone induces dissociation of the receptor-(3H)TRH com- plex with a half-life of 14 min. The binding of TRH is not altered by 10 pM melanocyte-stimulating hormone- release inhibiting hormone, lysine-vasopressin, adreno- corticotropin, growth hormone, prolactin, luteinizing hormone, insulin, glucagon, L-thyroxine, or L-triiodo- thyronine. K+ and Mg++ increase formation of the recep- tor-TRH complex at optimal concentrations of 5-25 mM and 0.5-2.5 mM, respectively, with inhibition at higher concentrations. Ca++ inhibits binding of TRH at all
Programming effective respiratory immunity to influenza with combination microparticle adjuvants (2020)

Abstract T cell-mediated immunity (CMI) can provide long-lived protection following parenteral immunization, but eliciting durable and protective CMI in the mucosa remains a significant challenge. Here, using polylactic-co-glycolic acid (PLGA)-based cationic pathogen-like particles (PLPs) for delivery of TLR agonists, we have investigated novel ways of presenting vaccine components to the immune system to simulate the potent innate immune stimulating effects of pathogens. We generated micro particle sized PLPs loaded with TLR4 (glucopyranosyl lipid adjuvant, GLA) and/or TLR9 (CpG) agonists, and formulated them with and without a mucosal delivery enhancing carbomer-based nano-emulsion adjuvant (ADJ). These adjuvants delivered intranasally to mice safely elicited robust and durable influenza nucleoprotein (NP)-specific CD8+/CD4+ effector and tissue-resident memory responses in lungs and airways. PLPs delivering TLR4 versus TLR9 agonists drove phenotypically and functionally distinct populations of effector and memory T cells. Following influenza virus challenge, functional and phenotypic attributes of effector T cells unique to the individual PLP formulation were associated with disparate levels of viral control in the respiratory tract. These studies demonstrate: (1) how adjuvant formulations affect effector/memory T cell differentiation in the lungs; (2) feasibility of using PLGA-based PLPs in vaccine formulations to elicit protective T cell immunity in the respiratory tract.
Regional Coronary Venous Oxygen Saturation and Myocardial Oxygen Tension following Abrupt Changes in Ventricular Pressure in the Isolated Dog Heart (1974)

Regional coronary venous oxygen saturation and myocardial oxygen tension (PO 2 ) in isolated dog hearts were measured using two different methods--a new technique of microscopic oximetry and an improved oxygen electrode. Both methods yielded similar results. In studies of the isolated perfused dog heart developing a constant left ventricular systolic pressure, mean coronary venous oxygen saturation of blood in the subendocardial veins of the left ventricle was significantly lower than that in the subepicardial veins. Following abrupt increases in systolic pressure, subendocardial coronary venous saturations fell to even lower levels. Following abrupt decreases in systolic pressure, the mean subendocardial coronary venous oxygen saturation increased to levels above those in the blood of the subepicardial veins. These findings agree with the hypothesis that transient underperfusion and overperfusion of the subendocardial layers of the left ventricle occur with abrupt increases and decreases in ventricular pressure, respectively.
A Variational Framework for Tissue Velocimetry in Vascular Optical Coherence Elastography (2004)

A variational approach to tissue velocimetry in optical coherence elastography (OCE) is presented. It exploits prior information about vessel wall velocities to reduce the sensitivity of conventional tracking methods to speckle decorrelation and noise.
Decoding Reed-Muller Codes with Successive Factor-Graph Permutations. (2021)

This paper presents a novel successive factor-graph permutation (SFP) scheme that significantly improves the error-correction performance of Reed-Muller (RM) codes under successive-cancellation list (SCL) decoding. In particular, we perform maximum-likelihood decoding on the symmetry group of RM codes to carefully select a good factor-graph permutation on the fly. We further propose an SFP-aided fast SCL decoding that significantly reduces the decoding latency while preserving the error-correction performance of the code. The simulation results show that for the third and fourth order RM codes of length $256$, the proposed decoder reduces up to $85\%$ of the memory consumption, $78\%$ of the decoding latency, and more than $99\%$ of the computational complexity of the state-of-the-art recursive projection-aggregation decoder at the frame error rate of $10^{-3}$.
Analysis Framework For Extensions of SRv6 Encapsulation (2020)

This document provides a framework for analysis of multiple proposals
to extend SRv6 encapsulation with the objective of minimizing
encapsulation size or leveraging legacy equipment. It defines relevant
metrics to evaluate each proposal.