gebhart/patrepeval huggingface dataset:
Radiation and Dose-densification of R-CHOP in Aggressive B-cell Lymphoma With Intermediate Prognosis: The UNFOLDER Study (2023)

UNFOLDER (Unfavorable Young Low-Risk Densification of R-Chemo Regimens) is an international phase-3 trial in patients 18-60 years with aggressive B-cell lymphoma and intermediate prognosis defined by age-adjusted International Prognostic Index (aaIPI) of 0 and bulky disease (≥7.5 cm) or aaIPI of 1. In a 2 × 2 factorial design patients were randomized to 6× R-CHOP-14 or 6× R-CHOP-21 (rituximab, cyclophosphamide, doxorubicin, vincristine, and prediso[lo]ne) and to consolidation radiotherapy to extralymphatic and bulky disease or observation. Response was assessed according to the standardized response criteria published in 1999, not including F-18 fluordesoxyglucose positron emission tomography/computed tomography (FDG-PET). Primary endpoint was event-free survival (EFS). A total of 695 of 700 patients were eligible for the intention-to-treat analysis. Totally 467 patients qualified for radiotherapy of whom 305 patients were randomized to receive radiotherapy (R-CHOP-21: 155; R-CHOP-14: 150) and 162 to observation (R-CHOP-21: 81, R-CHOP-14: 81). Two hundred twenty-eight patients not qualifying for radiotherapy were randomized for R-CHOP-14 versus R-CHOP-21. After a median observation of 66 months 3-year EFS was superior in the radiotherapy-arm versus observation-arm (84% versus 68%; <i>P</i> = 0.0012), due to a lower rate of partial responses (PR) (2% versus 11%). PR often triggered additional treatment, mostly radiotherapy. No significant difference was observed in progression-free survival (PFS) (89% versus 81%; <i>P</i> = 0.22) and overall survival (OS) (93% versus 93%; <i>P</i> = 0.51). Comparing R-CHOP-14 and R-CHOP-21 EFS, PFS and OS were not different. Patients randomized to radiotherapy had a superior EFS, largely due to a lower PR rate requiring less additional treatment (NCT00278408, EUDRACT 2005-005218-19).
Radiometria (2018)

La definición y análisis de las magnitudes radiométricas es imprescindible para entender la transferencia de flujo electromagnético a través de los sistemas ópticos. La cuestión fundamental es calcular cuánta potencia emitida por una fuente de luz es llevada hasta la superficie del detector, conocidas las características y situación geométrica del sistema óptico y de la fuente. Esta eficiencia radiométrica del sistema juega un papel decisivo en el valor del cociente señal ruido del sistema y en la detectividad de la imagen.
Comparative Study of Tungsten Monocarbide and Platinum as Counter Electrodes in Polysulfide-Based Photoelectrochemical Solar Cells (2009)

The stability and the electrocatalytic activity of polycrystalline tungsten monocarbide (WC) and platinum (Pt) electrodes in a concentrated polysulfide electrolyte were examined in an electrochemical half-cell and an integrated photoelectrochemical cell (PEC) device. Cyclic voltammetry and linear sweep voltammetry measurements found WC electrodes to be approximately twice as active as Pt electrodes toward polysulfide reduction. Electrochemical and X-ray photoelectron spectroscopy (XPS) measurements indicated that WC was stable in a polysulfide electrolyte, with no appreciable W sulfide formation. In contrast, XPS showed significant levels of sulfide species on the Pt surface, which might explain the differences in the electrochemical behavior of the two electrode materials. The performance of integrated PEC devices comprised of thin-film CdSe photoanodes and WC or Pt counter electrodes in a polysulfide electrolyte was consistent with that predicted from electrochemical half-cell measurements.
A 1.5V, 1.6Gb/s/pin, 1Gb DDR3 SDRAM with an Address Queuing Scheme and Bang-Bang Jitter Reduced DLL Scheme (2007)

A 1.6Gb/s/pin 1Gb DDR3 SDRAM with a CAS latency of 8 at 1.5 V is developed using an 80 nm dual poly CMOS process, which consumes 30 mA of IDD2N and 160 mA of IDD4R. With an address queuing scheme and a self-timed IOSA, IDD4R current can be reduced by 18 mA. To achieve 1.6Gb/s/pin operation, a bang-bang jitter free DLL with a split phase interpolator is employed.
Allorecognition Pathways (2007)

This chapter contains sections titled: Direct Pathway of Allorecognition Structure of the MHC Molecule and Allorecognition Role of Endogenous Peptides in Allorecognition Indirect Pathway of Allorecognition Indirect Allorecognition and Chronic Rejection Endothelial Cells and Allorecognition Site of Allorecognition Role of Allorecognition in the Effector Phase of Allograft Rejection Allorecognition Pathways and the Induction of Tolerance Conclusions References
New method for the resolution of the enantiomers of 5,6-Dihydroxy-2-Methyl-Aminotetralin by selective derivatization and HPLC analysis: Application to biological fluids (1996)

A new chiral derivatization procedure for the HPLC resolution of chiral catecholamines and structurally related compounds is described. The homochiral reagent, (+)-(R)-1-phenylethyl isocyanate (RPEIC), was added to separate and quantitate the enantiomers of rac-5,6-dihydroxy-2-methyl-aminotetralin, the main metabolite of rac-5, 6-diisobutyryl-2-methyl-aminotetralin, a potent dopamine agonist, by reversed-phase HPLC analysis. To avoid catecholamine degradation in the basic reaction medium and to obtain the selective and quantitative derivatization of the amino group of the compound, the reversible complex formation between diphenylborinic acid (DPBA) and the catechol group, in alkaline medium, was performed before homochiral isocyanate addition. The RPEIC derivatization was completed in 30 min and then the DPBA complex was dissociated by adding dilute acid. The structure of intermediates and urea derivatives was confirmed by mass spectometry. The use of an electrochemical detector, operating in redox mode, allowed HPLC quantitation of enantiomers at the nanogram level in plasma and urine. The derivatization procedure is also suitable for other catecholamine-related compounds.
Anomalous ferromagnetic resonance spectra of Ni crystals (1988)

The authors have shown that the ferromagnetic resonance spectra of Ni crystals stabilized on the surface of silica gel and obtained by reduction at low temperature of bound nickel chloride are anomalous in character, with several maxima in the low-field part of the spectrum. In accordance with available data, such spectra may be explained both by formation of Ni crystals on the surface of the support (the crystallographic structure of the Ni lattice may differ substantially from face-centered cubic), and by the appearance of some fraction of ferromagnetic crystals in the superparamagnetic ensemble of supported Ni crystals.
Diode-pumped lasers using highly doped Yb:Gd2O3 and Yb:Y2O3 crystals grown by the flux method (orale) (2013)

International audience
Motion Estimation with Similarity Constraint and its Application to Distributed Video Coding (2007)

In this paper we present a new motion estimation scheme that minimizes the objective distance function with a constraint of similarity measure to exploit the motion correlation among adjacent pixel blocks with similar statistics features. We formulate this correlation as a similarity measure on the motion vectors between the current pixel block and its neighboring blocks weighted by the corresponding statistical similarity. We then use this similarity measure as a constraint in the objective distance function to reduce the noise effects and improve performance by effectively trading off the difference in the pixel values with the smoothness in the adjacent motion vectors. Thus, in motion estimation, our new scheme not only minimizes the pixel differences but tries to preserve the motion smoothness among statistically similar neighbors. We applied this new motion estimation scheme to a distributed video coding system for side information generation for Wyner-Ziv decoding and compared its performance to the scheme without similarity constraint. The results have shown that our motion estimation scheme can achieve significant gains in the fidelity of the side information and the decoded Wyner-Ziv frames over the scheme without the similarity constraint.
Supplementary Tables 1-2 from Synthesis and Anticancer Properties of Water-Soluble Zinc Ionophores (2023)

Supplementary Tables 1-2 from Synthesis and Anticancer Properties of Water-Soluble Zinc Ionophores
Synthesis of pheromone-oriented emergent behavior of a silkworm moth (2002)

The purpose of this research is to clarify moth emergent behavior by synthesis with currently developed tools, including living sensors and recurrent neural networks. The antennae on a silkworm moth are very sensitive compared with artificial gas sensors. These living antennae can be used as living gas sensors that can detect pheromone molecules with high sensitivity. Recurrent artificial neural networks are applied for controlling the pheromone tracing. As a result, a mobile robot with living antennae can follow a stream of pheromone like a male silkworm moth. The small numbers of neurons can generate moth-like behavior, including casting, and turning while interacting with the environment.
A non-exothermic cell-embedding tissue-mimicking material for studies of ultrasound-induced hyperthermia and drug release (2013)

A platform for in vitro work for activation of thermally sensitive liposomes using high intensity focused ultrasound (HIFU)-induced hyperthermia was established. The TMM presents similar acoustic properties and thermal response to liver tissue over a broad range of ultrasound exposure conditions.
Hypoxia as an Initiator of Neuroinflammation: Microglial Connections (2005)

Hypoxia, which is a lowered physiological oxygen tension, is an important biological signal as well as a component of many diseases. In central nervous system, hypoxia is associated with brain injury following the ischemic stroke. Recent studies indicate that hypoxia may not only induce a direct neuronal damage, but it may also initiate inflammatory responses by activating microglia. Toxic inflammatory mediators produced by activated microglia under hypoxic conditions exacerbate the neuronal injury during cerebral ischemia. Pharmacological inhibition of hypoxic activation of microglia may prove to be neuroprotective against ischemic stroke.
G-raff (2015)

We present an elevating tangible block, G-raff that supports spatial interaction in a tabletop computing environment. The elevating head part of G-raff moves according to the given height and angle data. We adopted two rollable metal tape structures to create large movements with a small volume block. On the head part, a smartphone can be mounted either horizontally or vertically. G-raff becomes a device that can connect a mobile device with a tabletop computer, thus a new spatial representation and control interaction is made. This paper introduces the design details, key features and applications of G-raff. We report on the results of a preliminary user study and discuss future work to improve the elevating device. This work contributes to maximizing the availability of augmented reality space above the tabletop display.
M13 Bacteriophage Coat Proteins Engineered for Improved Phage Display (2006)

This chapter describes a method for increasing levels of protein fusions displayed on the surfaces of M13 bacteriophage particles. By introducing mutations into the anchoring M13 coat protein, protein display levels can be increased by up to two orders of magnitude. Experimental methods are presented for the design, construction, and screening of phage-displayed libraries for improved protein display.
A multicenter study to standardize reporting and analyses of fluorescence-activated cell-sorted murine intestinal epithelial cells (2013)

Fluorescence-activated cell sorting (FACS) is an essential tool for studies requiring isolation of distinct intestinal epithelial cell populations. Inconsistent or lack of reporting of the critical parameters associated with FACS methodologies has complicated interpretation, comparison, and reproduction of important findings. To address this problem a comprehensive multicenter study was designed to develop guidelines that limit experimental and data reporting variability and provide a foundation for accurate comparison of data between studies. Common methodologies and data reporting protocols for tissue dissociation, cell yield, cell viability, FACS, and postsort purity were established. Seven centers tested the standardized methods by FACS-isolating a specific crypt-based epithelial population (EpCAM+/CD44+) from murine small intestine. Genetic biomarkers for stem/progenitor (Lgr5 and Atoh 1) and differentiated cell lineages (lysozyme, mucin2, chromogranin A, and sucrase isomaltase) were interrogated in target and control populations to assess intra- and intercenter variability. Wilcoxon's rank sum test on gene expression levels showed limited intracenter variability between biological replicates. Principal component analysis demonstrated significant intercenter reproducibility among four centers. Analysis of data collected by standardized cell isolation methods and data reporting requirements readily identified methodological problems, indicating that standard reporting parameters facilitate post hoc error identification. These results indicate that the complexity of FACS isolation of target intestinal epithelial populations can be highly reproducible between biological replicates and different institutions by adherence to common cell isolation methods and FACS gating strategies. This study can be considered a foundation for continued method development and a starting point for investigators that are developing cell isolation expertise to study physiology and pathophysiology of the intestinal epithelium.
<title>Wide field-of-view coherent detection</title> (1997)

The concept of a wide field-of-view coherent detection insensitive to the wavefront distortions of the signal to be detected is proposed. The principal of this detection is based on two-wave mixing in photorefractive materials. The experimental validation of this concept is demonstrated at (lambda) equals 0.5 micrometers using a photorefractive crystal of Bi<SUB>12</SUB>SiO<SUB>20</SUB>. The sensitivity of the detection is theoretically and experimentally analyzed. It led to the conception of a wide field-of-view coherent detection demonstrator operating in the eye-safe band using a photorefractive crystal of CdTe. The application of this device to vibrations analysis of a mechanical structure and the determination of its resonance frequency are demonstrated.
Analysis of the convergence behavior of adaptive distributed-arithmetic echo cancellers (1993)

Adaptive distributed-arithmetic echo cancellers are well suited for full-duplex high-speed data transmission. They allow a simpler implementation than adaptive linear transversal filters, since multiplications are replaced by table look-up and shift-and-add operations. Various tradeoffs between the number of operations and the number of memory locations of the look-up tables can be achieved by segmenting the echo canceller delay line into sections of shorter length. Adaptivity is achieved by a decision-directed stochastic gradient algorithm to adjust the contents of the look-up tables. The author adopts the mean-square error criterion to investigate the convergence behavior of adaptive distributed-arithmetic echo cancellers. Under the assumption that the look-up values are statistically independent of the symbols stored in the echo canceller delay line, he obtains an analytical expression for the mean-square error as a function of time. The maximum speed of convergence and the corresponding optimum adaptation gain are also determined. Simulation results for a full-duplex quaternary partial response class-IV system are presented and compared with theoretical results.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
New Mononuclear and Polynuclear Perfluoroarylmetalate Cocatalysts for Stereospecific Olefin Polymerization (2004)

Mononuclear and polynuclear perfluoroarylborate, -aluminate, and -gallate cocatalysts for metallocene-mediated olefin polymerization have been synthesized as trityl fluoride adducts of known perfluoroarylmetalloid cocatalysts. Propylene polymerization experiments using these species as cocatalysts with the Cs-symmetric precatalyst [Me2C(Cp)(fluorenyl)]ZrMe2 reveal a marked counteranion dependence of polymerization activity, product polymer syndiotacticity, and relative [m] and [mm] stereoerror abundance, with the polynuclear perfluoroaryl cocatalysts uniformly giving enhanced product polymer stereoregularity vs the neutral analogues.
Engineered Nasal Cartilage by Cell Homing (2014)

These findings represent the first attempt to engineer cartilage tissue by cell homing for rhinoplasty, and could potentially serve as an alternative material for augmentative and reconstructive rhinoplasty.
Improved Procedure for the Synthesis of Enamine N-Oxides (2008)

An improved procedure for the preparation of enamine N-oxides involving aminolysis of epoxides, chlorination, N-oxidation, and dehydrochlorination is described. Although isolated beta-chloroamine N-oxides are prone to rearrangements when isolated, these side reactions can be slowed by the presence of stabilizing organic acids. The scope and limitations of this strategy are discussed.
AuCl3-Catalyzed Synthesis of 5-Bromomethyl Oxazoles from Amino Acids (2011)

Reported is the one-pot synthesis of 5-bromomethyl oxazoles by sequential gold(III)-catalyzed cyclization of amino acid derived propargyl amides to form intermediate A, followed by bromination to give the observed products in good yield. This work builds upon the results of Hashmi who developed the AuCl3-catalyzed cyclization to form oxazoles from amides (e.g., A. S. K. Hashmi., J. P. Weyrauch, W. Frey, J. W. Bats Org. Lett. 2004, 6, 4391). However, both Hashmi and the current authors found the reaction fails when non-terminal alkynes are used. The present method overcomes this limitation by intercepting a reactive intermediate (observed using ¹H NMR spectroscopy during the cyclization by the Hashmi group) to form a reactive bromide.
Low-Intensity Electrostimulation Enhances Neuroregeneration and Improves Erectile Function in a Rat Model of Cavernous Nerve Injury (2022)

This study demonstrates that LIES of the CN after CN injury protects CN structure, enhances EF recovery, and prevents corpora cavernosal remodeling. Sturny M, Karakus S, Fraga-Silva R, et al. Low-Intensity Electrostimulation Enhances Neuroregeneration and Improves Erectile Function in a Rat Model of Cavernous Nerve Injury. J Sex Med 2022;19:686-696.
Supplementary File 6 from Genome-Wide Functional Synergy between Amplified and Mutated Genes in Human Breast Cancer (2023)

Supplementary File 6 from Genome-Wide Functional Synergy between Amplified and Mutated Genes in Human Breast Cancer
Endocrine Disorders in Fanconi Anemia: Recommendations for Screening and Treatment (2015)

Individuals with FA should be routinely screened for endocrine abnormalities, including evaluation of growth; glucose, insulin, and lipid metabolism; thyroid function; puberty; gonadal function; and bone mineral metabolism. Inclusion of an endocrinologist as part of the multidisciplinary patient care team is key to providing comprehensive care for patients with FA.
Continuous monitoring of pulsed HIFU beams using dual-mode ultrasound array systems (2012)

We have previously described several DMUA prototypes with therapeutic and imaging capabilities suited for image-guided surgery. A fully real-time system capable of intermittent therapy/imaging operation to allow for high frame rate imaging during therapeutic has been developed. This approach allows for real-time characterization of echoes from the target region at the focal spot within milliseconds of the initiation of the therapeutic pHIFU beam. For example, at intensity levels of ∼8000 W/cm2 at 1.15 MHz, analysis of echo data preand post-beamforming shows spotty transient activity from within the pHIFU focus, indicative of cavitation. Ex vivo tissue samples were exposed to pHIFU beams of durations < 300 ms at intensity levels in the range of 2500-8000 W/cm2 with interruptions to analyze echo data at frame rates from 100 to 2000 fps. Examination of treated tissue samples shows correspondence between the transient echoes and the nature of the induced lesion (when present). Coupled with the DMUA system>s ability to refocus the pHIFU beam at > 1000 updates per second, this approach offers the physician a unique capability of modulating the exposure with millisecond resolution. Examples of monitoring and control of single-and multiple-focus DMUA patterns will be presented and discussed.
Scanning SWATH acquisition enables high-throughput proteomics with chromatographic gradients as fast as 30 seconds (2019)

Abstract Bridging genotype to phenotype, the proteome has increasingly become of major importance to generate large, longitudinal sample series for data-driven biology and personalized medicine. Major improvements in laboratory automation, chromatography and software have increased the scale and precision of proteomics. So far missing are however mass spectrometric acquisition techniques that could deal with very fast chromatographic gradients. Here we present scanning SWATH, a data-independent acquisition (DIA) method, in which the DIA-typical stepwise windowed acquisition is replaced by a continuous movement of the precursor isolation window. Scanning SWATH accelerates the duty cycles to a few hundreds of milliseconds, and enables precursor mass assignment to the MS2 fragment traces for improving true positive precursor identification in fast proteome experiments. In combination with 800 µL/min high-flow chromatography, we report the quantification of 270 precursors per second, increasing the precursor identifications by 70% or more compared to previous methods. Scanning SWATH quantified 1,410 Human protein groups in conjunction with chromatographic gradients as fast as 30 seconds, 2,250 with 60-second gradients, and 4,586 in conjunction with 5-minute gradients. At high quantitative precision, our method hence increases the proteomic throughput to hundreds of samples per day per mass spectrometer. Scanning SWATH hence enables a broad range of new proteomic applications that depend on large numbers of cheap yet quantification precise proteomes.
A DME based area navigation systems for GPS/WAAS interference mitigation in general aviation applications (2002)

The Federal Aviation Administration is leading the National Airspace System modernization effort, in part by supplanting traditional air traffic services with GPS aided by the wide and local area augmentation systems (WAAS & LAAS). Making GPS the sole-means of navigation will enhance safety, flexibility and efficiency of operations for all aircraft ranging from the single engine general aviation aircraft to the complex commercial jet-liners. This transformation of the National Airspace System will be gradual and the build-up to a sole-means GPS capability is expected to occur concurrently with the de-commissioning of a significant number of existing ground-based navigational facilities. Temporary interruptions of GPS services due to intentional or unintentional interference during this transition period could present significant problems for general aviation aircraft. To successfully deal with such outage scenarios, this paper discusses the use of an existing radio-navigation aid, the distance measuring equipment (DME), to provide a redundant navigation system alongside GPS/WAAS during this phase out period. Specifically, a system that fuses a low-end DME receiver with low cost dead-reckoning sensors (inertial, air-data and magnetometers) is shown to provide an affordable area navigation capability for general aviation users. The justification for choosing DME over other ground based navigational aids is discussed. This back-up system allows a reduction of the number of operational radio-navigation aids required while still providing adequate coverage for navigation during the transition to a sole-means GPS National Airspace System.