gebhart/patrepeval huggingface dataset:
Inhibition of cellular phosphatidylinosito, turnover by psi‐tectorigenin (1988)

Psi-tectorigenin, an isoflavonoid, was isolated from a culture filtrate of actinomycetes as an inhibitor of epidermal growth factor-induced phosphatidylinositol turnover in cultured A431 cells. It inhibited phosphatidylinositol turnover with an IC50 of about 1 microgram/ml; thus, its inhibitory activity was 6-times stronger than that of genistein or orobol. When added to cultured A431 cells psi-tectorigenin inhibited phosphatidylinositol turnover without inhibiting epidermal growth factor receptor tyrosine protein kinase. Thus, psi-tectorigenin is a specific inhibitor of phosphatidylinositol turnover and may be a useful tool for the functional analysis of phosphatidylinositol turnover.
Food Allergy and Liver Function (2002)

[Background] Food allergies cause damage not only to the intestines of patients but to their livers as well, making it all the more important to discover what drugs are effective in preventing that damage. Accordingly, we studied the effectiveness of Chinese traditional medicine and FOS in helping to prevent damage caused by food allergies.[Methods] (1) 13C-methacetine was used to study the relationship between liver damage and cases of food allergy presentation.(2) Chinese traditional medicine (Hochu-Ekito = TJ-41) was administered orally to mice twice a day for 2 weeks in a drug study of the food allergy model.(3) The effect of FOS on fecal organic acid production was observed in a study of FOS-treated mice.[Results] (1) As a result of the 13CO2 excretion pattern, the relationship between liver function and food allergies was confirmed.(2) The serum ALT levels decreased in mice treated with TJ-41.(3) Short-chain fatty acids such as butyrate were significantly higher in the FOS-treated group than in the control group.[Conclusion] Damage not only to the intestines but also the liver of food allergy patients was confirmed. TJ-41 and FOS were found to prevent this allergy-related damage, showing that FOS is very useful for allergic patients.
Regulation of E-selectin expression in postischemic intestinal microvasculature (2000)

Monolayers of cultured endothelial cells exposed to hypoxia-reoxygenation exhibit a transcription-dependent increase in E-selectin expression and E-selectin-dependent neutrophil-endothelial cell adhesion. The overall objectives of this study were 1) to determine whether ischemia-reperfusion (I/R) promotes upregulation of E-selectin in vivo; 2) if so, to define the mediators of this response; and 3) to assess the contribution of E-selectin to I/R-induced neutrophil recruitment. The dual-radiolabeled monoclonal antibody (MAb) technique was used to measure E-selectin expression in the intestinal vasculature. Ischemia was induced by complete occlusion (30-60 min) of the superior mesenteric artery followed by 3-24 h of reperfusion. Increasing durations of ischemia elicited progressively increasing (2- to 5-fold) levels of E-selectin expression, with the peak response noted after 45 min of ischemia and 5 h of reperfusion. Subsequent experiments revealed that I/R-induced increase in E-selectin expression (at 5 h) is significantly blunted in transgenic mice that overexpress Cu,Zn-superoxide dismutase or by treatment of wild-type mice with either a blocking antibody against tumor necrosis factor (TNF)-alpha or an inhibitor of nuclear factor-kappaB (NF-kappaB) activation (PS341). Administration of an E-selectin-specific MAb dramatically reduced I/R-induced recruitment of neutrophils in the intestine. These findings suggest that superoxide and TNF-alpha mediate gut I/R-induced E-selectin expression via an NF-kappaB-dependent mechanism; this upregulation of E-selectin contributes significantly to I/R-induced neutrophil recruitment.
Deep Learning-based Human Implantable Nano Molecular Communications (2020)

In this paper, we propose a novel nano-molecular communication system, including a nano receiver design and detection strategies. We show how machine intelligence can be incorporated into the practical implementation of nano communications. We introduce a testbed employing a biosensor chip as a receiver. The chip is made to be sufficiently small to be implanted under the human skin with no harm while detecting concentrations of glucose molecules over time. Molecules are released by a transmitter, to convey information through a thin pipe. For this configuration, the channel model is unknown, and the sensor dynamics can differ with according to the manufacturing process. Therefore, it is more desirable to find a universal strategy than using closed-form channel expressions so that it can be less sensitive to the channel and sensor variation. Learning-based approaches are likely to solve the problem. Therefore, in this paper, we suggest detection strategies with and without machine learning. We first describe our intuitions of nanomachine design from observations, and we show how the learning-based techniques can benefit the system by reducing the design burden and enhancing the accuracy of data detection. The study concludes by showing sample results of real data transmission.
A Flexible Water Content Probe for Unsaturated Soil Column Experiments (2006)

A commercially available soil moisture probe was modified by replacing rigid electrode waveguides with flexible electrode traces that can be attached to the interior of soil column walls. This new design minimizes soil packing difficulties and potential bias in water and solute flow pathways commonly associated with rigid probe installations in column experiments. Tests demonstrated that the modified flexible electrode design maintains a voltage response that is proportional to the electrode trace length and is reduced by approximately one‐half when only one side of the electrode trace is in contact with the soil media. Laboratory experiments confirmed that the longer electrode traces attached to the interior of a column wall have a comparable sensitivity of that of a commercially available rigid probe inserted horizontally across the diameter of a soil column. The replacement of the rigid electrode with a flexible electrode offers an improved method of measuring the water content in solute transport experiments while minimizing sensor intrusion into laboratory soil columns.
Field-Effect Transistors using Boron-Doped Diamond Epitaxial Films (1989)

Metal-semiconductor field-effect transistors (MESFET's) have been fabricated on a boron-doped diamond epitaxial film. This is the first report of a planar type transistor using a diamond film.
Data cache and direct memory access in programming mediaprocessors (2001)

Mediaprocessors provide high performance by using both instruction- and data-level parallelism. Because of the increased computing power, transferring data between off- and on-chip memories without slowing down the core processor's performance is challenging. Two methods, data cache and direct memory access, address this problem in different ways.
Supplementary Figure S4 from Integrated Human and Murine Clinical Study Establishes Clinical Efficacy of Ruxolitinib in Chronic Myelomonocytic Leukemia (2023)

&lt;p&gt;Supplementary Figure S4 compares baseline cytokine levels between responding and non-responding patients.&lt;/p&gt;
Closed-Loop Identification of Carotid Sinus Baroreflex Transfer Characteristics Using Electrical Stimulation. (2000)

Although random aortic pressure (AOP) perturbation according to a binary white noise sequence enables us to estimate open-loop dynamic characteristics of the carotid sinus baroreflex under closed-loop conditions, the necessity of arterial catheter implantation limits the applicability of this method in freely moving animal experiments. Thus, we explored a closed-loop system identification method using electrical stimulation. In 6 anesthetized and vagotomized rabbits, we stimulated the aortic depressor nerve with a binary white noise sequence (0-10 Hz) under baroreflex closed-loop conditions while measuring cardiac sympathetic nerve activity (SNA) and AOP. We used a closed-loop identification method to estimate the peripheral arc transfer function from SNA to AOP. The peripheral arc transfer function approximated a second-order low-pass filter and its fitted parameters did not differ from those obtained by an open-loop identification method (dynamic gain: 1.16+/-0.32 vs. 1.02+/-0.11; natural frequency: 0.08+/-0.03 vs. 0.09+/-0.03 Hz; damping ratio: 1.53+/-0.15 vs. 1.57+/-0.21). In 6 different rabbits, we applied intermittent rapid pacing (396 beats/min) under baroreflex closed-loop conditions to estimate the neural arc transfer function from AOP to SNA. The neural arc transfer function approximated a first-order high-pass filter and its fitted parameters did not differ from those obtained by an open-loop identification method (dynamic gain: -1.15+/-0.45 vs. -1.06+/-0.05; corner frequency: 0.12+/-0.05 vs. 0.13+/-0.03 Hz). In conclusion, the closed-loop identification method using electrical stimulation is effective to estimate the neural and peripheral arc transfer functions.
Minimal residual hairy cell leukemia eradication with moxetumomab pasudotox: phase 1 results and long-term follow-up (2018)

Anti-CD22 moxetumomab pasudotox achieved 46% complete remissions (CRs) in previously reported phase 1 testing in relapsed/refractory hairy cell leukemia (HCL; n = 28). The importance of minimal residual disease (MRD) after CR in HCL is unknown. A 21-patient extension cohort received 50 µg/kg every other day for 3 doses in 4-week cycles. These patients plus 12 previously reported at this upper dose level received 143 cycles without dose-limiting toxicity. The combined 33-patient cohort achieved 64% CR and 88% overall response rates, with median CR duration of 42.4 months. Of 32 50-µg/kg patients evaluable for MRD by bone marrow aspirate flow cytometry (most stringent assessment), median CR duration was 13.5 (4.9-42.4) months in 9 MRD-positive CRs vs 42.1 (24.0-69.2) months in 11 MRD-negative CRs (<i>P</i> < .001). Among MRD-negative CRs, 10 patients had ongoing CR, 9 without MRD, at end of study. To our knowledge, moxetumomab pasudotox is the only nonchemotherapy regimen that can eliminate MRD in a significant percentage of HCL patients, to enhance CR duration. Repeated dosing, despite early neutralizing antibodies, increased active drug levels without detectable toxicity from immunogenicity. The activity and safety profiles of moxetumomab pasudotox support ongoing phase 3 testing in HCL. This trial was registered at www.clinicaltrials.gov as #NCT00586924.
Enhancing Innate and Adaptive Immune Systems by Cold Atmospheric Plasma (CAP) and Its Antitumor Immunity (2022)

Cold atmospheric plasma (CAP) is a near room temperature ionized gas, generated under non-equilibrium discharge conditions. Here we show that a short exposure of rat peritoneal exudate macrophages and T-cells to CAP in vitro, triggered an inflammatory phenotype leading to better antigen-presenting and effector cell function respectively. Different from previous studies mainly using immortalized cell lines, both macrophage and T-cells in this study were primary cells isolated from mice. Furthermore, ex-vivo exposure of T-cells to CAP, followed by their adoptive transfer into tumor-bearing mice resulted in a strong antitumor effect in vivo. Mechanistically, CAP seems to disrupt tolerogenic pathways leading to enhanced production of pro-inflammatory cytokines while limiting the production of anti-inflammatory cytokines and the expression of inhibitory molecules such as programmed death-ligand 1 (PD-L1). CAP represents therefore a novel, non-toxic and easy to deliver technology to augment the function of immune cells and enhance antitumor responses when used as a component of T-cell adoptive immunotherapies strategies or, potentially in combination with other cancer immunotherapeutic approaches.
Anion Exchange Composite Membranes Composed of Quaternary Ammonium-Functionalized Poly(2,6-dimethyl-1,4-phenylene oxide) and Silica for Fuel Cell Application (2021)

Anion exchange membranes (AEMs) with good alkaline stability and ion conductivity are fabricated by incorporating quaternary ammonium-modified silica into quaternary ammonium-functionalized poly(2,6-dimethyl-1,4-phenylene oxide) (QPPO). Quaternary ammonium with a long alkyl chain is chemically grafted to the silica <i>in situ</i> during synthesis. Glycidyltrimethylammoniumchloride functionalization on silica (QSiO<sub>2</sub>) is characterized by Fourier transform infrared and transmission electron microscopic techniques. The QPPO/QSiO<sub>2</sub> membrane having an ion exchange capacity of 3.21 meq·g<sup>-1</sup> exhibits the maximum hydration number (λ = 11.15) and highest hydroxide ion conductivity of 45.08 × 10<sup>-2</sup> S cm<sup>-1</sup> at 80 °C. In addition to the high ion conductivity, AEMs also exhibit good alkaline stability, and the conductivity retention of the QPPO/QSiO<sub>2</sub>-3 membrane after 1200 h of exposure in 1 M potassium hydroxide at room temperature is about 91% ascribed to the steric hindrance offered by the grafted long glycidyl trimethylammonium chain in QSiO<sub>2</sub>. The application of the QPPO/QSiO<sub>2</sub>-3 membrane to an alkaline fuel cell can yield a peak power density of 142 mW cm<sup>-2</sup> at a current density of 323 mA cm<sup>-2</sup> and 0.44 V, which is higher than those of commercially available FAA-3-50 Fumatech AEM (OCV: 0.91 V; maximum power density: 114 mW cm<sup>-2</sup> at current density: 266 mA cm<sup>-2</sup> and 0.43 V). These membranes provide valuable insights on future directions for advanced AEM development for fuel cells.
Dietary Carnosine And Anserine Inhibits High-intensity Exercise-induced Decrease In Rat Sarcoplasmic Reticulum Ca2+ -handling (2007)

Carnosine and anserine are histidine-containing dipeptides that are present in the brain, heart, skin, liver, kidney and skeletal muscle. Various physiological actions have been ascribed to carnosine in skeletal muscle including pH buffering, acting as an antioxidant, the regulation of Ca2+sensitivity and excitation-contraction (E-C) coupling. PURPOSE: The hypothesis tested in this study was that dietary chicken breast extract (CBEX), a rich source of carnosine and anserine, would attenuate deteriorations in sarcoplasmic reticulum (SR) function that occur with high-intensity exercise. METHODS: The CBEX was prepared from the pectoralis major muscles of chicken and mixed with 9 volumes of standard rat chow. Following 5 weeks of dietary CBEX, SR Ca2+-uptake rate, Ca2+-release rate and Ca2+-stimutated ATPase activity were examined in homogenates of the superficial portion of vastus lateralis muscles from rats subjected to high-intensity treadmill running for 2.5 min. RESULTS: Dietary CBEX caused an approximately 15 and 45% increased (P < 0.01) in the muscle carnosine and anserine concentrations, respectively, but no changes in the SR Ca2+-handling ability, i.e., Ca2+-uptake and release rates, in resting muscle. Our data confirm that high-intensity exercise evokes depressions in SR Ca2+-handling. In spite of the same run time, SR Ca2+-handling was reduced to a lesser degree in muscle from CBEX-containing chow-fed rats, compared to standard chow-fed rat. Alterations in SR Ca2+-ATPase activity were not paralleled by those in Ca2+-uptake. Dietary CBEX elicited a 12.4% reduction (P < 0.05) in the catalytic activity of resting muscle. After exercise, the activity was depressed to similar extents between CBEX-containing chowand standard chow-fed rats. CONCLUSIONS: These results implicate the modified SR Ca2+-handling ability as one contributor to inhibition of the fatigue development resulting from carnosine and anserine.
Early onset Alzheimer's disease in a South American pedigree from Argentina (1995)

We report the clinical, SPET, immunohistochemical and DNA features of an early-onset familial Alzheimer's disease (FAD) in an Argentine pedigree of South American indian ethnic background. Pedigree spans 5 generations comprising more than 110 biological relatives. Clinical data supported the diagnosis of early onset FAD (mean age at onset 38.9 years) in 10 family members, including 3 with pathological confirmation (mean age at death 48.5). The pattern of transmission suggested autosomal dominant inheritance. Prominent features were mood changes, early language impairment, myoclonus, seizures and cerebellar signs. SPET displayed bilateral frontal, temporo-parietal and cerebellar hypoperfusion in early stages and in an asymptomatic member at risk, suggesting that SPET may have predictive value in this family. Immunohistochemistry showed β amyloid deposits within neuritic plaques and vessel walls and no anti-PrP immunoreactivity. DNA analysis showed no abnormalities in the β amyloid precursor protein gene. The identification of additional genetic defects in well characterized independent FAD pedigrees will contribute to the understanding of the pathogenesis of Alzheimer's disease.
DeepAuth (2018)

With the increasing volume of transactions taking place online, mobile fraud has also increased. Mobile applications often authenticate the user only at install time. The user may then remain logged in for hours or weeks. Any unauthorized access may lead to financial, criminal or privacy losses. In this work, we leverage currently available built-in motion sensors in smartphones to learn users' behavioral characteristics while interacting with the mobile device to provide an implicit re-authentication mechanism that enables a frictionless and secure user experience in the application. This approach improves the generality as well as power efficiency of the authentication mechanism compared to using the camera feed which involves (a) specific hardware, (b) higher battery usage and (c) privacy concerns. We present DeepAuth as a generic framework for re-authenticating users in a mobile app. In our approach, we use time and frequency domain features extracted from motion sensors and a long short-term memory (LSTM) model with negative sampling to build a re-authentication framework. The framework is able to re-authenticate a user with 96.70% accuracy in 20 seconds from a set of data collected from 47 volunteers.
Optimizing Network Slicing in Distributed Large Scale Infrastructures: From Heuristics to Controlled Deep Reinforcement Learning (2023)

This paper summarizes the PhD thesis and the 10 associated publications on the optimization of network slice placement in large-scale distributed infrastructures by focusing on online heuristics and approaches based on Deep Reinforcement Learning (DRL). First, we rely on Integer Linear Programming (ILP) to propose a data model for on-Edge and on-network slice placement. Second, we leverage an approach called Power of Two Choices (P2C) to propose an online heuristic adapted to support placement on large-scale distributed infrastructures while incorporating Edge-specific constraints like latency. Finally, we investigate the use of Machine Learning (ML) methods, specifically DRL, to increase the scalability and automation of network slice placement by considering a multi-objective optimization approach to the problem. We will go through the extensive evaluation work that provide encouraging results about the advantages of the proposed approaches when used in realistic network scenarios.
Sister chromatid exchange distribution in various human tissues exposed to MMC and BrdU. (1983)

The effect of two known mutagens on different human tissues was examined in an attempt to determine if tissue specific responses exist in SCE distribution on chromosome. The tissues included human lymphocytes, skin fibroblasts, ovarian and testicular cells. All cell types were exposed to varying concentrations of 5-bromodeoxyuridine (BrdU), and mitomycin C (MMC). The numbers of SCEs were recorded from each tissue. Results indicated that certain of the tissues tested appeared more sensitive to particular agents. Results also showed that in all the tissues tested the larger chromosomes in groups A to C had greater numbers of SCEs than did the smaller chromosomes in groups D to G. There were very few SCEs in F and G group chromosomes including Y.
Deploying Dynamic On-Board Signal Processing Schemes for Multibeam Satellite Systems (2019)

This paper designs dynamic onboard signal processing schemes in a multiple gateway multi-beam satellite system where full frequency reuse pattern is considered among the beams and feeds. In particular, we deploy on-board Joint Precoding, Feed selection and Signal switching mechanism (JPFS) so that the following advantages are realized, I) No need of Channel State Information (CSI) exchange among the gateways and satellite, since the performance of precoding is highly sensitive to the quality of CSI, II) In case one gateway fails, rerouting signals through other gateways can be applied without any extra signal processing, III) Properly selecting on-board feed/s to serve each user which generates maximum gain toward corresponding user, IV) Flexibly switching the signals received from the gateways to requested users where each user can dynamically request traffic from any gateway, and V) Multiple users with multiple traffic streams can be dynamically served at each beam. However, deploying such JPFS architecture imposes high complexity to the satellite payload. To tackle this issue, this study aims at deploying JPFS that can provide affordable complexity at the payload. In addition, while increasing the data demand imposes extensive bandwidth resources requirement in the feeder link, the proposed JPFS design works efficiently with available feeder link resources even if the data demand increases. The proposed design is evaluated with a close-to-real beam pattern and the latest broadband communication standard for satellite communications.
The crystal structure of leucyl/phenylalanyl‐tRNA‐protein transferase from Escherichia coli (2007)

Leucyl/phenylalanyl-tRNA-protein transferase (L/F-transferase) is an N-end rule pathway enzyme, which catalyzes the transfer of Leu and Phe from aminoacyl-tRNAs to exposed N-terminal Arg or Lys residues of acceptor proteins. Here, we report the 1.6 A resolution crystal structure of L/F-transferase (JW0868) from Escherichia coli, the first three-dimensional structure of an L/F-transferase. The L/F-transferase adopts a monomeric structure consisting of two domains that form a bilobate molecule. The N-terminal domain forms a small lobe with a novel fold. The large C-terminal domain has a highly conserved fold, which is observed in the GCN5-related N-acetyltransferase (GNAT) family. Most of the conserved residues of L/F-transferase reside in the central cavity, which exists at the interface between the N-terminal and C-terminal domains. A comparison of the structures of L/F-transferase and the bacterial peptidoglycan synthase FemX, indicated a structural homology in the C-terminal domain, and a similar domain interface region. Although the peptidyltransferase function is shared between the two proteins, the enzymatic mechanism would differ. The conserved residues in the central cavity of L/F-transferase suggest that this region is important for the enzyme catalysis.
CSF proteome: a protein repository for potential biomarker identification (2005)

Proteomic analysis is not limited to the analysis of serum or tissues. Synovial, peritoneal, pericardial and cerebrospinal fluid represent unique proteomes for disease diagnosis and prognosis. In particular, cerebrospinal fluid serves as a rich source of putative biomarkers that are not solely limited to neurologic disorders. Peptides, proteolytic fragments and antibodies are capable of crossing the blood-brain barrier, thus providing a repository of pathologic information. Proteomic technologies such as immunoblotting, isoelectric focusing, 2D gel electrophoresis and mass spectrometry have proven useful for deciphering this unique proteome. Cerebrospinal fluid proteins are generally less abundant than their corresponding serum counterparts, necessitating the development and use of sensitive analytical techniques. This review highlights some of the promising areas of cerebrospinal fluid proteomic research and their clinical applications.