gebhart/patrepeval huggingface dataset:
Possible Role of L-Carnosine in the Regulation of Blood Glucose through Controlling Autonomic Nerves (2003)

Mammalian muscles synthesize L-carnosine, but its roles were unknown. Previously, we found in rats that the administration of a certain amount of L-carnosine elicited an inhibition of the hyperglycemia induced by the injection of 2-deoxy-D-glucose (2DG) into the lateral cerebral ventricle (LCV), and that intravenous injection of L-carnosine inhibited sympathetic nerves and facilitated the parasympathetic nerve. Moreover, the suppressive effect of L-carnosine on the hyperglycemia induced by 2DG was eliminated by thioperamide, a histaminergic H3 receptor. These findings suggested that L-carnosine might control the blood glucose level through regulating autonomic nerves via H3 receptor. To further clarify the function of L-carnosine, we examined its role in the control of the blood glucose. In this experiment, the following results were observed in rats: (i) A certain amount (0.01% or 0.001%) but not a larger amount (0.1%) of L-carnosine given as a diet suppressed the hyperglycemia induced by LCV-injection of 2DG (2DG-hyperglycemia); (ii) LCV-injection but not the injection into the intraperitoneal space (IP) of a certain amount of L-histidine suppressed the 2DG-hyperglycemia; (iii) treatments of diphenhydramine, an H1 antagonist, and alpha-fluoromethylhistidine, an inhibitor of histamine-synthesizing enzyme, reduced the 2DG-hyperglycemia; (iv) the plasma L-carnosine concentration and carnosinase activity showed daily changes; (v) the plasma L-carnosine concentration was significantly lower in the streptozotocin-diabetic rats; (vi) exercise by a running wheel tended to increase carnosine synthase activity in the gastrocnemius muscle and elevated the plasma L-carnosine concentration in the dark (active) period, and enhanced the plasma carnosinase activity in the light period; (vii) IP-injection of certain amount of L-carnosine stimulated the feeding response to IP-injection of 2DG. These findings suggest a possibility that L-carnosine released from muscles due to exercise functions to reduce the blood glucose level through the regulation of the autonomic nerves.
METALLIC AND CERAMIC MATERIALS RESEARCH Task Order 0003: Metallic Materials, Processing and Performance Development for Air Force Applications (2015)

Abstract : This final report details progress made on various topics related to advanced metallic and advanced metallic composites. In this program, the work covered the material needs for enabling a variety of missions including access to space and hypersonic flight for global access and meeting the continuing demand for higher performance, more efficient jet engines. The focus areas covered a broad range of technologies comprising thermal protection materials, fiber lasers for directed energy, Integrated Computational Materials Science and Engineering (ICMSE), superalloy development, hybrid disks, hot structures for hypersonics, functional materials for energy needs, and nanoenergetic materials for munitions needs. This report will cover three categories of research: advanced ceramics/composites, advanced metals, and functional metals. Much of this research has been published elsewhere in the open literature as journal articles and papers, and is referenced in the text.
1180 nm Linearly Polarized Fiber Laser with High Slope Efficiency Employing Low Loss Ytterbium Doped Polarization Maintaining Solid Photonic Bandgap Fiber (2010)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text M. Kashiwagi, K. Takenaga, K. Ichii, T. Kitabayashi, S. Tanigawa, K. Shima, S. Matsuo, M. Fujimaki, and K. Himeno, "1180 nm Linearly Polarized Fiber Laser with High Slope Efficiency Employing Low Loss Ytterbium Doped Polarization Maintaining Solid Photonic Bandgap Fiber," in Conference on Lasers and Electro-Optics 2010, OSA Technical Digest (CD) (Optica Publishing Group, 2010), paper CWC7. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Clinical and Radiological Outcomes in Reverse Total Shoulder Arthroplasty by Inclination Angle With a Modular Prosthesis (2021)

The influence of the humeral inclination in reverse total shoulder arthroplasty (RTSA) is not well understood. The purpose of this study was to determine outcomes and complications after RTSA with an inclination of 135° or 155° in a modular prosthesis. American Shoulder and Elbow Surgeons (ASES), visual analog scale (VAS), Single Assessment Numeric Evaluation (SANE), and Simple Shoulder Test (SST) scores, as well as forward elevation (FE), abduction (ABD), and external rotation (ER), were assessed after a minimum 2-year follow-up. Scapular notching and radiolucency were assessed according to Sirveaux and Lévigne. A total of 121 patients with a mean age of 69.7±7.3 years were evaluated after a mean of 36.5±8 months. The inclination was set to 135° in 80.2% and to 155° in 19.8% of patients. There was no significant difference between the groups for ASES, VAS, SANE, and SST scores. The FE (<i>P</i>=.022) and ABD (<i>P</i>=.002) were significantly higher for the 155° inclination group. Complication rates were not significantly different between the groups. Scapular notching was significantly more common with a 155° inclination (<i>P</i>=.01), whereas humeral radiolucency was not correlated. All outcome scores improved significantly from pre- to postoperative (<i>P</i>≤.001). Reverse total shoulder arthroplasty leads to significant improvements in pain, range of motion, and outcome scores after mid-term follow-up. Overall, the inclination angle does not significantly affect clinical outcomes or the complication rate after RTSA at mid-term follow-up. However, an inclination of 155° shows significantly greater FE and ABD, although it results in a significantly higher rate of scapular notching. Cases with scapular notching are associated with significantly reduced mean ASES scores and ER as well as significantly higher VAS scores. [<i>Orthopedics</i>. 2021;44(4):e527-e533.].
Separation of gases using solubility-selective polymers (1997)

Polymeric membranes for the separation ofsupercritical gases are typically glassy and achieve high selectivity by a size-sieving mechanism. This property permits some polymers to be more than 100 times more permeable to hydrogen (kinetic diameter = 2.89A) than to methane (kinetic diameter = 3.8A), despite the fact that hydrogen solubility is markedly lower than methane solubility. The permeation properties of glassy polymers for the separation of supercritical gases follow an immutable trade-off relationship : polymers that are more permeable tend to be less selective and vice versa. In contrast, new gas. separation applications, such as removal of higher hydrocarbons from natural gas for dew-point and heating-value control, removal of higher hydrocarbons from hydrogen streams, and separation of valuable or toxic organic vapors from air or nitrogen streams, generally require membranes that are more permeable to the larger, more condensable components in a mixture (i.e. vapors) than to smaller supercritical gases such as hydrogen or nitrogen. Membrane materials that are highly permeable to the larger components in a mixture must derive high selectivity from the relative difference in solubility of the components in the membrane matrix. That is, polymers with little size-sieving ability are useful for such separations. Rubbery polymers, such as polydimethylsiloxane, and ultra-high free volume, 'superglassy'polymers, such as poly(1-trimethylsilyl-1-propyne), are examples of two different classes of solubility-selective polymers for these new applications. These polymers are more permeable to large molecules than to smaller, supercritical gases. Interestingly, polymers exhibiting high permeability to organic vapors also exhibit high selectivity for these components in mixtures with supercritical gases. This behavior leads to the compelling conclusion that well-designed materials for these separations will have both high permeability and high selectivity.
Highly Efficient Solution-Processed Organic Light-Emitting Diodes Containing a New Cross-linkable Hole Transport Material Blended with Commercial Hole Transport Materials (2021)

A new small-molecular thermally cross-linkable material {[4-(9-phenyl-9<i>H</i>-carbazol-4-yl)phenyl]-bis-(4'-vinylbiphenyl-4-yl)-amine} (PCP-bis-VBPA, PbV) containing the styrene moiety was synthesized for hole transport layers in wet processed organic light-emitting diodes (OLEDs). It was found that PbV exhibited relatively high glass temperatures above 154 °C and a triplet energy (<i>T</i><sub>1</sub>) greater than 2.81 eV. This new synthetic hole transport material (HTM) forms very uniform films after cross-linking reaction with little pin-holes, although it was small-molecule-based cross-linkable HTM. However, to solve the certain minor non-uniformity caused by pinholes with various sizes, a semi-interpenetrating network was formed with well-known polymeric HTM with high mobility [e.g., poly(9,9-dioctylfluorene-<i>co</i>-<i>N</i>-(4-butylphenyl)diphenyl amine), TFB, or poly(<i>N</i>,<i>N</i>'-bis-4-butylphenyl-<i>N</i>,<i>N</i>'-bisphenyl)benzidine, poly-TPD]. As a result, we successfully fabricated red phosphorescent OLED showing an efficiency of about 16.7 cd/A and 12.4% (external quantum efficiency) if we applied PbV blended with 20% of TFB or poly-TPD. In particular, the efficiency and lifetime are significantly improved by 1.5 and 4.5 times, respectively, compared to those of the control device without using blended HTM.
CXCR4 mutations affect presentation and outcomes in patients with Waldenström macroglobulinemia: A systematic review (2019)

<b>Introduction</b>: The genomic landscape of Waldenström macroglobulinemia (WM) is characterized by recurrent <i>MYD88</i> (<i>MYD88<sup>L265P</sup></i>) and <i>CXCR4</i> mutations (<i>CXCR4<sup>MUT</sup></i>), detected in 90% and 30% of cases, respectively. The role of <i>CXCR4<sup>MUT</sup></i> in clinical features and outcomes to therapy in WM patients is evolving. <b>Areas covered</b>: We performed a systematic review aimed at evaluating the prevalence of <i>CXCR4<sup>MUT</sup></i> in WM patients, and at assessing differences in clinical features and outcomes to therapy between WM patients with and without <i>CXCR4<sup>MUT</sup></i>. Seventeen studies were included in our analysis. The pooled prevalence of <i>CXCR4<sup>MUT</sup></i> in WM patients was 31%; 34% in <i>MYD88<sup>L265P</sup></i> and 5% in <i>MYD88<sup>WT</sup></i> patients. <i>CXCR4<sup>MUT</sup></i> were associated with higher serum IgM levels and higher risk of hyperviscosity than <i>CXCR4<sup>WT</sup></i> patients. Very good partial response (VGPR) and progression-free survival (PFS) rates to ibrutinib, with and without rituximab, appeared lower in <i>CXCR4<sup>MUT</sup></i> than in <i>CXCR4<sup>WT</sup></i> patients. Response and PFS rates were not affected by <i>CXCR4<sup>MUT</sup></i> status on patients treated with proteasome inhibitors. <b>Expert opinion</b>: Our systematic review shows that WM patients with <i>CXCR4<sup>MUT</sup></i> have specific clinical features and have lower response and PFS rates to BTK inhibitors. Our findings support standardization of <i>CXCR4</i> testing and development of CXCR4-directed therapy.
Synthesis and Properties of Gold Nanoparticle Arrays Self-Organized on Surface-Deposited Lysozyme Amyloid Scaffolds (2014)

In this study, amyloid fibers prepared from hen egg white lysozyme (HEWL) are specifically mediating the assembly of citrate-capped gold nanoparticles, on glass and silicon substrates. The organization of nanoparticles is investigated for nanoparticle diameters of 5, 15, and 25 nm, using variable deposition times, and under a range of pH, salt, citric acid and nanoparticle concentrations. The observed periodic self-organization of nanoparticles is mainly influenced by the interparticle interactions rather than by the spacing of binding groups at the surface of the amyloid fiber template. For a fixed ionic strength of 2.3 mM and particle concentration, the interparticle distance increases with the nanoparticle diameter in agreement with the values predicted by the Derjaguin, Landau, Verwey, and Overbeek (DLVO) theory. UV–visible spectroscopy measurements show a red shift of the 520 nm plasmon absorption peak associated with spherical gold nanoparticles up to 650 nm upon aggregation or decrease in the interparticle distance. Such protein templates deposited on technologically relevant surfaces allow the self-assembly of inorganic nanoparticle arrays with functional optoelectronic properties.
P-139 Pacemaker insertion or cholinesterase inhibitors cessation after syncope in Alzheimer disease patients? (2003)

UROPACE 2003
Reconfigurable Ultrathin Beam Redirecting Metasurfaces for RCS Reduction (2017)

A reconfigurable metasurface concept is proposed for dynamically tuning the direction of the maximum radar cross section (RCS). The basic unit cell of this metasurface is a loaded mushroom-type structure. By capacitively loading the unit cells, the reflection phase across the metasurface can be controlled, thus allowing incident plane waves to be scattered in any arbitrary direction. As a consequence, the RCS of the metasurface can be considerably reduced for the specular direction. Unlike previous static design approaches that yield fixed beam patterns, the reconfigurable aspect of the metasurface allows dynamic control over the placement of the RCS peaks and/or nulls.
VP1: Combined Local Delivery of Tacrolimus and Stem Cells in Fibrin Gel is a Viable Potential Treatment for Enhancing Peripheral Nerve Regeneration (2022)

INTRODUCTION: The immunosuppressive and neuroregenerative potential of tacrolimus (FK506) may overcome the rejection of stem cells to enhance nerve regeneration. The aim of this study was to determine the feasibility and effectiveness of combining local, sustained delivery of tacrolimus (FK506) with stem cells. MATERIALS AND METHODS: The drug release profile of local FK506 over the course of 35 days was evaluated in phosphate-buffered saline (PBS). FK506 was incorporated into fibrin gel in poly(lactic-co-glycolic) acid (PLGA) microspheres in concentrations of 0.01 ng/mL and 100 ng/mL and incubated in phosphate-buffered saline (PBS) at physiological temperature. Microspheres were prepared and characterized according to validated protocols by Tajdaran et al. (2015). Adipose derived mesenchymal stem cells (MSCs) were cultured in collected PBS to mimic systemic exposure representing released concentrations at day 7, 15 and 28 from 0.01 ng/mL and 100 ng/mL microspheres. MSCs were cultured in the following groups: (i) hydrogel only, (ii) PLGA empty microspheres in hydrogel, (iii) Hydrogel Infused with Stem cells and Tacrolimus (HIST) 0.01 ng/mL, and (iv) HIST 100 ng/mL. Staining against CD90 was conducted to confirm stem cell characterization. MSC viability was evaluated at 24h, 48h, 72h, and seven days using Live/Dead staining and MTS assays. RESULTS: Microspheres containing 0.01 ng/mL showed depletion of FK506 by 13 days. FK506 microspheres containing 100 ng/mL revealed a sustained release up to 35 days. An inflation point was observed at day 15 due to erosion of gel, resulting in an increase of FK506 release. CD90 staining confirmed stem cell characterization. MSCs were viable up to seven days and no significant differences in viability were found between groups. CONCLUSION: Encapsulation of 100 ng/mL FK506 microspheres and MSCs in hydrogel is feasible and has strong potential to enhance survival of transplanted cells, which may ultimately lead to improved nerve regeneration.
Role of Rock Saturation Condition on Rock–Mud Interaction: Sandstone Geomechanics Study (2022)

The rock saturation condition affects the rock elastic and strength characteristics due to the role of fluid-rock interaction. However, the role of this parameter has not been studied well for mud-rock exposure during drilling operations. Hence, this study targets to assess the role of different rock saturation conditions on the rock geomechanics changes during the rock exposure for the drilling fluids. During the drilling operation, the mud filtrate invades the drilled formation pore system and replaces the saturating fluid and consequent alterations occur for the rock elastic moduli and failure properties. The current study employed Berea Buff sandstone rock type with different saturation conditions (brine-saturated, dry, and oil-saturated) to interact with drilling mud (water-based) through the filtration test to mimic the downhole rock-mud exposure under pressure, temperature, and time conditions. Extensive laboratory analysis was accomplished that covered the scratching test to get the strength of rock samples, acoustic data determination, elastic moduli evaluation, and scanning electron microscopy to assess the internal alterations of the rock pore system. The obtained results showed that the oil-saturated sample showed the least filtration characteristics for the rock-mud exposure and the best condition to maintain the rock strength from deterioration compared to the dry and brine-saturated samples. The rock strength showed a weakening behavior for the brine-saturated and dry samples by 5 and 18% respectively, while the oil-saturated sample showed only a 2% strength reduction after the mud exposure. Poisson's ratio showed a 21% increase for the brine-saturated sample and the dry sample showed a small increase from 0.2 to 0.22, while the oil-saturated sample maintains a stable Poisson's ratio at 0.24. Young's modulus showed an increase for the dry and brine-saturated rock samples by 10 and 7%, respectively, while a 25% reduction for the oil-saturated. The spectrometry analysis results showed the internal changes in the rock samples' pore system for the brine-saturated and dry samples, while the oil-saturated sample showed no internal changes that maintain the rock structure and strength after the mud exposure.
Characteristics of Al 2 O 3 /native oxide/n-GaN capacitors by post-metallization annealing (2019)

Abstract This work investigated characteristics of Al 2 O 3 /native oxide/n-GaN MOS capacitors by post-metallization annealing (PMA). A native oxide interlayer which composed of ε - and γ -Ga 2 O 3 phases (Native oxide) and the reduced amount of one (Reduced) on n-GaN were prepared by cleaning only a sulfuric acid peroxide mixture (SPM) and both SPM and buffered hydrofluoric acid, respectively. The effect of trimethylaluminum precursor on removal of a native oxide layer was not observed during Al 2 O 3 deposition using atomic layer deposition. An as-grown capacitor (Native oxide) exhibited a small flatband voltage ( V fb ) hysteresis of ∼30 mV and a large frequency dispersion, suggesting that the initial growth of the Al 2 O 3 resulted in the formation of electrical defects on the GaN surface. Both the V fb hysteresis and frequency dispersion were drastically improved by PMA of the device at 300 °C. The positive fixed charge values ( Q IL ) estimated from the relationships between capacitance equivalent thickness and V fb were +6.1 × 10 12 and +0.4–1.0 × 10 12 cm −2 for as-grown and PMA-processed capacitors in the PMA temperature range of 300 °C–600 °C, respectively. The interface state density ( D it ) determined using a conductance method was also significantly reduced (by an order of magnitude) after PMA processing at 300 °C. These trends in the Q IL and D it data were observed in both the Native oxide and Reduced capacitors, indicating that this interlayer does not greatly affect fixed charge generation at the Al 2 O 3 /native oxide and Al 2 O 3 /modified native oxide interfaces. As a result, two types of treatments result in insignificant difference in the electrical properties of the capacitors.
Borono-Catellani-Type Reactions (2019)

Catellani reaction enables multi-functionalization of aromatic rings. Originally, Catellani reaction starts from oxidative addition of aryl halide to zerovalent palladium species. This reaction pattern restricts a variation of reactant. In this review, recently developed palladium(II)-initiated borono-Catellani reactions are discussed.
Integrating Biomedical Knowledge to Model Pathways of Prostate Cancer Progression (2007)

Due to pathologic, histologic, and biologic variation within prostate cancers, profiling the genetic changes associated with disease progression has been difficult. Although initial integration of data from profiling studies had been limited by platform variation, bioinformatic tools and analytic techniques have enabled integrative analysis of profiling studies and the identification of more robust and valid profiles. The identification of key transition points in the progression of prostate cancer relies on profiling precursor lesions and "pure" cell populations. Utilizing laser-capture microdissection to isolate 101 cell populations, a more specific genetic profile of progression from benign epithelium to metastatic disease was obtained. This laser-capture profile was analyzed in the context of the molecular concepts map (MCM), a compendium of over 20,000 molecular concepts including other expression profiles of prostate cancer, to obtain an integrative molecular model of progression. The conceptual connections associated with progression confirm that prostate cancer biology is largely driven by pathways related to androgen signaling and epithelial cell biology; however, further analysis of concepts associated with progression suggests stromal factors are highly associated with progression of prostate cancer. The effect of stromal signatures on the progression model suggests the impact of stromal signature downregulation may reflect both a change in the epithelia:stroma ratio within higher grade tumors and also a microenvironment influence on prostate epithelia. Analyzing complex gene expression signatures in the context of molecular concepts improves integrative models and may improve detection, prognostication, or targeted therapy.
A rapid on-chip single nucleotide polymorphism detection directly from human blood (2015)

This paper reports on a silicon/glass based microsystem for the fast detection of single nucleotide polymorphisms (SNPs) directly from on-chip filtered human blood. A crossflow micro-pillar filter is used for purifying lysed blood. It provides an easy solution for on-chip blood sample preparation. After purification, polymerase chain reaction (PCR) was no longer inhibited. The purified DNA solution is then tested for the detection of specific SNPs in a thermally insulated micro-cavity by real-time PCR. As a proof of principle, a successful on-chip detection of two SNPs in human CYP2C9 gene is demonstrated. The SNP profiling using our device took less than 40 minutes from sample to result.
Capillary zone electrophoresis tandem mass spectrometry detects low concentration host cell impurities in monoclonal antibodies (2015)

We have evaluated CZE-ESI-MS/MS for detection of trace amounts of host cell protein impurities in recombinant therapeutics. Compared to previously published procedures, we have optimized the buffer pH used in the formation of a pH junction to increase injection volume. We also prepared a 5-point calibration curve by spiking 12 standard proteins into a solution of a human mAb. A custom CZE-MS/MS system was used to analyze the tryptic digest of this mixture without depletion of the antibody. CZE generated a ∼70-min separation window (∼90-min total analysis duration) and ∼300-peak capacity. We also analyzed the sample using ultra-performance LC-MS/MS. CZE-MS/MS generated approximately five times higher base peak intensity and more peptide identifications for low-level spiked proteins. Both methods detected all proteins spiked at ∼100 ppm level with respect to the antibody.