gebhart/patrepeval huggingface dataset:
Ultraviolet-B photodestruction of a light-harvesting complex. (1996)

Cyanobacteria are important contributors to global photosynthesis in both marine and terrestrial environments. Quantitative data are presented on UV-B-induced damage to the major cyanobacterial photosynthetic light harvesting complex, the phycobilisome, and to each of its constituent phycobiliproteins. The photodestruction quantum yield, phi295 nm, for the phycobiliproteins is high (approximately 10(-3), as compared with approximately 10(-7) for visible light). Energy transfer on a picosecond time scale does not compete with photodestruction. Photodamage to phycobilisomes in vitro and in living cells is amplified by causing dissociation and loss of function of the complex. In photosynthetic organisms, UV-B damage to light-harvesting complexes may significantly exceed that to DNA.
ChemInform Abstract: Mapping of Transition Metal Redox Energies in Phosphates with NASICON Structure by Lithium Intercalation. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Z-Scan Study of Nonlinear Optical Coupling of PtOx and Ge2Sb2Te5 of Near-Field Optical Recording Structure (2006)

The strong local nonlinear optical coupling properties of a 5 nm PtOx thin film sandwiched by two Ge2Sb2Te5 phase-change structures of a new type super-resolution near-field optical disk are investigated and observed by Z-scan experiments.
Superseding traditional indexes by orchestrating learning and geometry (2019)

We design the first learned index that solves the dictionary problem with time and space complexity provably better than classic data structures for hierarchical memories, such as B-trees, and modern learned indexes. We call our solution the Piecewise Geometric Model index (PGM-index) because it turns the indexing of a sequence of keys into the coverage of a sequence of 2D-points via linear models (i.e. segments) suitably learned to trade query time vs space efficiency. This idea comes from some known heuristic results which we strengthen by showing that the minimal number of such segments can be computed via known and optimal streaming algorithms. Our index is then obtained by recursively applying this geometric idea that guarantees a smoothed adaptation to the "geometric complexity" of the input data. Finally, we propose a variant of the index that adapts not only to the distribution of the dictionary keys but also to their access frequencies, thus obtaining the first distribution-aware learned index. The second main contribution of this paper is the proposal and study of the concept of Multicriteria Data Structure, namely one that asks a data structure to adapt in an automatic way to the constraints imposed by the application of use. We show that our index is a multicriteria data structure because its significant flexibility in storage and query time can be exploited by a properly designed optimisation algorithm that efficiently finds its best design setting in order to match the input constraints. A thorough experimental analysis shows that our index and its multicriteria variant improve uniformly, over both time and space, classic and learned indexes up to several orders of magnitude.
Decadal variability in acoustic thermometers interpreted with ocean models (1995)

Travel times of acoustic signals were measured between the bottom-mounted Kaneohe source near Oahu and seven SOSUS stations at 3000–4000-km distance during 1983–1989. The Naval Research Laboratory hydrodynamic eddy resolving model yields changes in travel time whose standard deviations are consistent with the data. The model predicts that between 1981–1993, Rossby waves modify travel times by one second. Mesoscale eddies modify travel times little compared to Rossby waves. The largest Rossby waves are descendants of El Nino. Travel times changes are sensitive indicators of predictable features in the Naval Research Laboratory model. [Work supported by the Strategic Environmental Research and Development Program, managed by the Advanced Research Projects Agency.]
Vibrational states for hydrogen in palladium (1991)

Vibrational potentials for hydrogen isotopes in PdH and ${\mathrm{Pd}}_{4}$H are determined from first-principles total-energy calculations. The strong anharmonicity of the potential for H around octahedral sites must be taken into account beyond perturbation theory. For PdH good quantitative agreement of our calculated vibration energies with inelastic-neutron-scattering (INS) results is achieved, allowing a reinterpretation of the INS spectra. For lower H concentrations (${\mathrm{Pd}}_{\mathit{n}}$H, n=4, 8, 16, and 32) the influence of local lattice relaxations on the vibration potentials and energies is important. Furthermore, metastable states confined to tetrahedral sites in Pd are found for the heavier isotopes $^{2}\mathrm{D}$ and $^{3}\mathrm{T}$.
Exploiting unused storage resources to enhance systems' energy efficiency, performance, and fault-tolerance. (2006)

The invention of better fabrication materials and processes in solid-state devices has led to unprecedented technological breakthroughs in computer hardware. Today's system software, however, often cannot take full advantage of the hardware's rapidly improving capabilities, thus resulting in idling resources, e.g., unoccupied memory and disk space. To make hardware operate more efficiently and to reduce the amount of idle resources, this thesis proposes several techniques that can harness such resources to the benefit of users. Although there are many different types of hardware resources, this thesis focuses on the reclamation of idle resources in the storage hierarchy. First, we implemented a pure software technique to reduce the power dissipation of main memory. By aggregating unmapped and unused memory pages and powering down unused memory ranks, a significant amount of energy can be saved with little or no performance degradation. Next, we explored several architectural-level solutions that can more aggressively reduce energy, but at the expense of performance. We also developed techniques to exploit unused disk capacity to improve disks' performance and energy-efficiency. These techniques are realized in our implementation of the Free Space File System (FS2). Unlike traditional file systems where extra disk space is not used, FS2 actively makes use of it to hold replicas of temporally-related data blocks that were poorly placed by the underlying file system. Using contiguous regions of free disk space to place related data blocks closer to one another enables in disk heads to work more efficiently. Free disk space may also be used to enhance the fault-tolerance of disks. The placement of replicas is shown to be critical to both the fault-tolerance and performance of file systems that make use of replicas. However, without a thorough understanding of how disks fail and how data become corrupted when failures occur, good data placement strategies are difficult to devise. We studied a large number of failed disks and analyzed their failure characteristics. This characterization study will help design more fault-tolerant file systems that can take advantage of today's large capacity hard drives.
Supplementary Table 1 from Identification of Inhibitors of ABCG2 by a Bioluminescence Imaging–Based High-Throughput Assay (2023)

Supplementary Table 1 from Identification of Inhibitors of ABCG2 by a Bioluminescence Imaging–Based High-Throughput Assay
Structure–Activity Relationships and in Vivo Evaluation of Quinoxaline Derivatives for PET Imaging of β-Amyloid Plaques (2013)

This letter describes the synthesis, structure-activity relationships, and in vivo evaluation of a new series of 2-phenylquinoxaline (PQ) derivatives for imaging β-amyloid (Aβ) plaques in Alzheimer's disease (AD). In experiments in vitro, the affinity of the derivatives for Aβ aggregates varied, with K i values of 0.895 to 1180 nM. In brain sections from AD patients, derivatives with a K i of less than 111 nM intensely labeled Aβ plaques, while those with values over 242 nM showed no marked labeling. In biodistribution experiments using normal mice, the derivatives showed good uptake into (4.69-7.59 %ID/g at 2 or 10 min postinjection) and subsequent washout from (1.48-3.08 %ID/g at 60 min postinjection) the brain. In addition, [(18)F]PQ-6 labeled Aβ plaques in vivo in APP transgenic mice, while it showed nonspecific binding in the white matter. Further structural optimization based on [(18)F]PQ-6 may lead to more useful PET probes for imaging Aβ plaques.
IKBT: Solving Symbolic Inverse Kinematics with Behavior Tree (2019)

Inverse kinematics solves the problem of how to control robot arm joints to achieve desired end effector positions, which is critical to any robot arm design and implementations of control algorithms. It is a common misunderstanding that closed-form inverse kinematics analysis is solved. Popular software and algorithms, such as gradient descent or any multi-variant equations solving algorithm, claims solving inverse kinematics but only on the numerical level. While the numerical inverse kinematics solutions are relatively straightforward to obtain, these methods often fail, due to dependency on specific numerical values, even when the inverse kinematics solutions exist. Therefore, closed-form inverse kinematics analysis is superior, but there is no generalized automated algorithm. Up till now, the high-level logical reasoning involved in solving closed-form inverse kinematics made it hard to automate, so it's handled by human experts. We developed IKBT, a knowledge-based intelligent system that can mimic human experts' behaviors in solving closed-from inverse kinematics using Behavior Tree. Knowledge and rules used by engineers when solving closed-from inverse kinematics are encoded as actions in Behavior Tree. The order of applying these rules is governed by higher level composite nodes, which resembles the logical reasoning process of engineers. It is also the first time that the dependency of joint variables, an important issue in inverse kinematics analysis, is automatically tracked in graph form. Besides generating closed-form solutions, IKBT also explains its solving strategies in human (engineers) interpretable form. This is a proof-of-concept of using Behavior Trees to solve high-cognitive problems.
Erratum (2006)

Berger, Richard A. MD; Valle, Craig Della MD; Jacobs, Joshua J. MD; Sheinkop, Mitchell B. MD; Rosenberg, Aaron G. MD; Galante, Jorge O. MD Author Information
Genomic Engineering and the Future of Medicine (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cystometric Evidence that Capsaicin-Sensitive Nerves Modulate the Afferent Branch of Micturition Reflex in Humans (1989)

Intravesical instillation of capsaicin (0.1 to 10 microM) in six patients (five with hypersensitive disorders of the lower urinary tract, one with benign prostatic hyperplasia) produced a concentration-related reduction of the first desire to void, bladder capacity and pressure threshold for micturition. At a threshold concentration of one microM, capsaicin also produced a warm to burning sensation referred to the suprapubic area during the collecting phase and to the urethra during micturition. All the patients with hypersensitive disorders of the lower urinary tract reported disappearance or marked attenuation of their symptoms for a few days after capsaicin application. In three other patients with hypersensitive disorders of the lower urinary tract, intravesical instillation of capsaicin's vehicle (0.1% ethanol in saline) did not produce significant cystometric changes nor modify the symptomatology. These observations provide the first indication that capsaicin-sensitive structures (nerves?) may be present in the human urinary bladder as they have been shown to occur in various other species.
Discovery and Characterization of 2-Nitro-5-(4-(phenylsulfonyl)piperazin-1-yl)-N-(pyridin-4-ylmethyl)anilines as Novel Inhibitors of the Aedes aegypti Kir1 (AeKir1) Channel (2019)

Mosquito-borne arboviral diseases such as Zika, dengue fever, and chikungunya are transmitted to humans by infected adult female Aedes aegypti mosquitoes and affect a large portion of the world's population. The Kir1 channel in Ae. aegypti ( AeKir1) is an important ion channel in the functioning of mosquito Malpighian (renal) tubules and one that can be manipulated in order to disrupt excretory functions in mosquitoes. We have previously reported the discovery of various scaffolds that are active against the AeKir1 channel. Herein we report the synthesis and biological characterization of a new 2-nitro-5-(4-(phenylsulfonyl) piperazin-1-yl)- N-(pyridin-4-ylmethyl)anilines scaffold as inhibitors of AeKir1. This new scaffold is more potent in vitro compared to the previously reported scaffolds, and the molecules kill mosquito larvae.
The effect of normal and calcium bicarbonate rich water replacement after sauna on muscle behaviour (2003)

Aim. The present investigation was undertaken to study if the different fluid replacement (normal vs calcium bicarbonate rich water) could influence heavy cycling performance and explosive power. The purpose of the present study is to compare the effect of water replacement during sauna bath using 2 different types of water intake: Normal vs calcium rich bicarbonate and very low sodium concentration (Sangemini, Italy) on muscle mechanical behaviour. Methods. A group of 27 healthy and moderately active students, 19 males and 8 females, randomly assigned in 2 groups have performed the same test protocol in 2 sessions. After 5 minutes of warming up on an electro-magnetically-braked cycle ergometer at 50 W for males and 35 W for females, and free revolutions per minute, and 3 minutes of static stretching the subjects performed a counter movement jump (CMJ) and after a modified Wingate test on the cycle ergometer for 60 s. The Wingate test started from 0 rpm and the torque was set at 0.7 Nm/kg body weight for the males and 0.67 Nm/kg body weight for the females. Mechanical power, synchronised with electromyography (EMG) analysis from the mm Vastus lateralis and medialis and Lactate (mM/L) were measured. In the 2nd session the subjects took first a Finnish sauna bath at 900 and 100% humidity. After sauna the subjects drunk water from a bottle ad libitum, and 1 hour after the sauna performed the 2nd test with the same protocol than in the 1st session. The Group A (Control group) took a normal water while the Group B (Experimental group) took a calcium bicarbonate rich water. Results. In the jumping performance the group treated with calcium water bicarbonate showed a significantly increase of height of the centre of gravity (31,6 +/- 7,12 cm vs 32,3 +/- 7,42 cm p<0,05) while the control group (33,6 +/- 6,5 cm vs 32,0 +/- 5,6 cm, p=n.s.) was negatively affected by normal water after the sauna bath. Average power, average power/body mass ratio, and EMGrms, no statistically significant differences were founded in both groups. The group treated with calcium water bicarbonate showed a decrease of lactate production post treatment test (12,3 +/- 1,9 mM/L vs 10,6 +/- 2,1 mM/L, p<0,05) while no difference was noted in the control group (11,9 +/- 1,8 mM/L vs 11,4 +/- 2,0 mM/L, p=n.s.). Also significant differences was found in the maximal lactate and the average power ratio. Conclusions. It seems that the supplement of calcium bicarbonate rich water could effect positively the negative effect of elevated (H+) on Ca2+ binding mechanism. This is a simple suggestions which, however cannot explain why the experimental subjects drinking calcium bicarbonate rich water developed lower blood [Lac-]. On basis of the present results it can be suggested that drinking calcium bicarbonate rich water helps the athletes to perform strenuous work by reducing the blood [Lac-] accumulation.
LTE radio network planning with HetNets: BS placement optimization using simulated annealing (2014)

In this paper, the optimization of base station (BS) deployment is investigated. After determining an approximate number of required BSs to cover an area of interest, the positions of these BSs are determined using the simulated annealing (SA) algorithm. Deployment using SA is compared to a benchmark approach consisting of a uniform deployment of the BSs over the area of interest. Scenarios with uniform user distribution are investigated, in addition to scenarios with Gaussian distribution. These latter scenarios correspond to a hotspot case, where users are concentrated in the center of a given area and the concentration is reduced as we move away from the center. BS deployment in heterogeneous networks was also investigated, and shown to lead to better results than a network with only macrocell BSs.
Publisher’s Note: Orbital Fluctuations and Orbital Flipping inRVO3Perovskites [Phys. Rev. Lett.99, 197201 (2007)] (2009)

Received 12 February 2009DOI:https://doi.org/10.1103/PhysRevLett.102.089901©2009 American Physical Society
Impaired Intracellular Energetic Communication in Muscles from Creatine Kinase and Adenylate Kinase (M-CK/AK1) Double Knock-out Mice (2003)

Previously we demonstrated that efficient coupling between cellular sites of ATP production and ATP utilization, required for optimal muscle performance, is mainly mediated by the combined activities of creatine kinase (CK)- and adenylate kinase (AK)-catalyzed phosphotransfer reactions. Herein, we show that simultaneous disruption of the genes for the cytosolic M-CK- and AK1 isoenzymes compromises intracellular energetic communication and severely reduces the cellular capability to maintain total ATP turnover under muscle functional load. M-CK/AK1 (MAK=/=) mutant skeletal muscle displayed aberrant ATP/ADP, ADP/AMP and ATP/GTP ratios, reduced intracellular phosphotransfer communication, and increased ATP supply capacity as assessed by 18O labeling of [Pi] and [ATP]. An analysis of actomyosin complexes in vitro demonstrated that one of the consequences of M-CK and AK1 deficiency is hampered phosphoryl delivery to the actomyosin ATPase, resulting in a loss of contractile performance. These results suggest that MAK=/= muscles are energetically less efficient than wild-type muscles, but an apparent compensatory redistribution of high-energy phosphoryl flux through glycolytic and guanylate phosphotransfer pathways limited the overall energetic deficit. Thus, this study suggests a coordinated network of complementary enzymatic pathways that serve in the maintenance of energetic homeostasis and physiological efficiency.
Chain reaction polymerization (1981)

The purpose of this paper is to attempt to present a reasonable, concise, but up-to-date overview of chain reaction polymerization. The article refers to many excellent papers and books on the subject.
Novel self-etching and antibacterial orthodontic adhesive containing dimethylaminohexadecyl methacrylate to inhibit enamel demineralization (2018)

Enamel demineralization is one of the most undesired side effects of fixed orthodontic treatment, which will lead to white spot lesions (WSLs) on tooth surfaces. The development of WSLs is due to prolonged accumulation of bacterial plaque and associated acid production. Self-etching adhesives have been used in orthodontic treatments with several advantages over the more traditional acid-etch method. However, current self-etching adhesives in orthodontic treatments have no antibacterial activity. The objectives of this study were to develop a self-etching and antibacterial orthodontic adhesive, and to investigate its enamel bond strength and antibacterial properties. A novel quaternary ammonium monomer dimethylaminohexadecyl methacrylate (DMAHDM) was incorporated into a commercial self-etching adhesive (Adper Easy One, 3M). It showed that the 5% DMAHDM appeared to be optimal in obtaining the strongest antibacterial function without compromising the enamel bond strength both at 15 min and after 30 days of immersion plus thermal cycling.
Performances sportives et génétique (2003)

Kahn Axel. Performances sportives et génétique. In: Les Cahiers de l'INSEP, n°34, 2003. Expertise et sport de haut niveau. pp. 163-174.
Novel synthesis of large area ZnTe:O films for high-resolution imaging applications (2011)

Oxygen doped zinc telluride is a bright scintillator with one of the highest X-ray conversion efficiencies. These properties make it an ideal choice for wide range of X-ray imaging applications in biology and medicine. With an emission wavelength of 680 nm it is ideally suited for use with silicon imagers such as CCDs. In this paper we report a new co-evaporation process where the oxygen dopant concentration in the evaporated film is controlled by simultaneous evaporation of zinc oxide and zinc telluride charge. To date we have fabricated as large as 40 cm<sup>2</sup> area films measuring 50 &#956;m to 500 &#956;m in thickness. The fabrication and characterization details of these and other films are discussed in this paper.
Expression of the maize GALACTINOL SYNTHASE gene family: (I) Expression of two different genes during seed development and germination (2004)

GALACTINOL SYNTHASE (GOLS) acts on UDP‐galactose and myo ‐inositol to form galactinol. The production of galactinol is thought to be the committed step in the biosynthesis of the raffinose family oligosaccharides (RFOs), a group of carbohydrates hypothesized to play a number of roles in plant development. Three cDNAs for maize ( Zea mays L. inbred line B73) GOLS ( ZmGOLS ) were identified from the Pioneer Hi‐Bred expressed sequence database. The recombinant proteins from these cDNAs synthesize galactinol. Transcript amounts in developing and germinating seeds were determined using northern blot, ribonuclease protection assays, and multiplex RT‐PCR. ZmGOLS1 mRNA was not detected in any of the tissues examined. ZmGOLS3 transcripts accumulated late during seed development and were present in mature seeds but declined quickly to undetectable amounts following imbibition. Experiments in which germination was interrupted by desiccation, but not by cold, heat, or salt stress, detected ZmGOLS2 transcripts. Soluble sugar amounts and GALACTINOL SYNTHASE activity were determined for developing maize seeds as well as for mature seeds during germination and upon stress during germination. Neither enzyme activity nor galactinol or raffinose quantities could be related to ZmGOLS transcript abundance. Galactinol amounts were most closely related to myo ‐inositol quantities during development and early germination. Maturation desiccation appears to be a switch delineating a realm of expression for ZmGOLS3, predominant during seed development, from that of ZmGOLS2, principally associated with post‐imbibition dehydration stress.