gebhart/patrepeval huggingface dataset:
Abstract 107: Mechanism of anticancer activity of BPS-001 (lyophilized leech saliva extract) (2017)

Abstract Recent studies, investigating the composition and therapeutic potential of leech saliva have identified many peptides and proteins with multiple therapeutic properties including anti-thrombotic, antimicrobial and anti-metastatic. In vitro anti-cancer effects were shown in breast, prostate and lung cells lines. In vivo anticancer activity of the extract was shown in multiple breast and prostate cancer xenografts studied by our lab. In our previous studies, BPS-001 was non-toxic and demonstrated various activities including pro-apoptotic properties, inhibition of cellular adhesion, angiogenesis and downregulation of AR expression. To investigate the affected pathways, mechanistic studies were carried out using in vivo and in vitro treated samples. Protein expression in samples was determined by Western blotting of in vitro and in vivo samples. AR expression was measured using an eGFP reporter assay in LNCaP cells, with PSA also measured in the media using cobas e 411 analyzer. BPS-001 inhibited Proteinase Activated Receptor 1 (PAR-1) which is responsible for hormone like cellular signals in different cancer cells including those of the breast and prostate. Moreover, in LNCaP cells AR activation and PSA expression were significantly inhibited after treatment with BPS-001. Inhibition of PI3K and PLCG2 were also observed. It has been found that BPS-001 modulates a plethora of pathways which makes it a very promising candidate for treatment of cancer with an important advantage of low toxicity and potential resistance. Citation Format: Amr Ammar, Emma Guns, Omer Kucuk, Abdualrahman Abdualkader, Mohamed Alaama, A.B.M. Helal Uddin, Abbas Ghawi, Mohamed Hassona. Mechanism of anticancer activity of BPS-001 (lyophilized leech saliva extract) [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 107. doi:10.1158/1538-7445.AM2017-107
Cloning and expression of a cell wall associated protein gene of Mycobacterium tuberculosis. (1999)

Genomic library of Mycobacterium tuberculosis (SIHV) was constructed into T7 promoter based vector pBluescript II KS (+/-) in Escherichia coil. The expression of mycobacterial antigens from recombinants was detected by immunoscreening using E-coli-preabsorbed hyperimmune rabbit anti-M tuberculosis cell wall associated proteins serum. Among 980 clones tested by immunoscreening, a clone pJJ5 was found to produce mycobacterial antigen. This clone was further characterized by immunoblotting and found to produce a 36 kDa of cell wall associated antigen Detection of antibodies response to this antigen in the serum of the majority of the individuals with tuberculosis indicates that this antigen is capable of stimulating a humoral immune response.
Synthesis and Application of Bimetallic Zinc(II) Phenoxy-Imine Complexes as Initiators for Production of Lactide Polymers (2017)

This article reports the synthesis of two bimetallic zinc(II) complexes containing phenoxyimine ligands and their application as initiators of ring opening polymerization (ROP) of L-lactide (LA). The phenoxy-imine ligands were obtained from salicylaldehyde derivatives and 2,3,5,6-tetramethylphenylenediamine, yielding two bidentate regions per ligand. The reactions of both phenoxy-imine ligands with ZnEt 2 in the presence of n-BuOH afforded [Zn 2 (L1)(OBu) 2 ] and [Zn 2 (L2)(OBu) 2 ], which were characterized by elemental analysis, Fourier transform infrared (FTIR) and 1 H nuclear magnetic resonance (NMR) spectroscopy. In addition, the geometries of both complexes were investigated by DFT (B3LYP/LACVP**) calculations. [Zn 2 (L1)(OBu) 2 ] and [Zn 2 (L2)(OBu) 2 ] were tested as initiators of ROP of LA at 180 C using different LA/Zn molar ratios, namely 500, 1000 and 2500. Both complexes showed good activity, resulting in conversions up to 96% in 2 h. The poly-LLA exhibited average molecular weight (M w ) ranging from 45,000-92,000, relatively low polydispersity (M w /M n = 1.6-2.0) and high stereoregularity with melting temperature T m = 164 C.
Breaking Ed25519 in WolfSSL. (2017)

Ed25519 is an instance of the Elliptic Curve based signature scheme EdDSA that was recently introduced to solve an inconvenience of the more established ECDSA. Namely, both schemes require the generation of a value (scalar of the ephemeral key pair) during the signature generation process and the secrecy of this value is critical for security: knowledge of one such a value, or partial knowledge of a series of them, allows reconstructing the signer’s private key. In ECDSA it is not specified how to generate this random value and hence implementations critically rely on the quality of random number generators and are challenging to implement securely. EdDSA removes this dependence by deriving the secret deterministically from the message and a long-term auxiliary key using a cryptographic hash function. The feature of determinism has received wide support as enabling secure implementations and in particular deployment of Ed25519 is spectacular. Today Ed25519 is used in numerous security protocols, networks and both software and hardware security products e.g. OpenSSH, Tor, GnuPG etc.
BER sensitivity to mistiming in ultra-wideband impulse Radios-part I: nonrandom channels (2005)

We investigate timing tolerances of ultra wideband (UWB) impulse radios. We quantify the bit-error-rate (BER) sensitivity to epoch timing offset under different operating conditions, including frequency flat fading channels, dense multipath fading channels, multiple access with time hopping, and various receiver types including sliding correlators and RAKE combiners. Our systematic approach to BER derivations under mistiming can be extended to a wide range of channel fading types. Through analyses and simulations, we illustrate that the reception quality of a UWB impulse radio is highly sensitive to both timing acquisition and tracking errors. In particular, time-hopping-based multiple-access systems exhibit little tolerance to acquisition errors, and the energy capture capability of a RAKE combiner can be severely compromised by mistiming.
Comparison of ICD shock rates in Japanese and non‐Japanese patients in the PainFree SST study (2018)

There was no difference in the appropriate shock rate between Japan and other geographies. The inappropriate shock rate in Japan was low, although it was slightly higher compared to other geographies due to baseline characteristics, including a higher prevalence of permanent AF. There was not a statistically significant difference after adjusting for baseline characteristics.
Implications for the Origin of GRB 070201 from LIGO Observations (2008)

Submitted to Cornell University's online archive www.arXiv.org in 2008 by Szabolcs M\\'arka. Post-print sourced from www.arxiv.org.
Synthesis and antiviral evaluation of a seven-membered sugar ring nucleoside analog, 9-(5-deoxy- -D-allo-septanosyl)-adenine (2008)

The first example of a nucleoside analogue bearing a 5'-deoxy-beta-D-allo-septanose as the sugar moiety was synthesized and evaluated as a potential inhibitor of several virus replication.
Optimization of Electrically Pumped Microdisk Lasers Integrated with a Nanophotonic SOI Waveguide Circuit (2007)

Electrically-injected continuous-wave lasing was achieved in InP-based microdisks coupled to a sub-micron silicon-on-insulator waveguide, with 0.6 mA threshold current and up to 7 μW coupled output power. We present strategies to improve the device performance.
SURFAXIN ATTENUATES INFLAMMATION AND PRESERVES LUNG STRUCTURE VERSUS ANIMAL-DERIVED SURFACTANT REPLACEMENT THERAPY (SRT) IN VENTILATED-HYPEROXIC RESPIRATORY DISTRESS SYNDROME (RDS) MODELS (2008)

Objective Surfaxin® contains KL4 (sinapultide), a novel synthetic peptide that functionally mimics SP-B, a protein with anti-inflammatory properties insufficient in animal-derived surfactant replacement therapy (SRT). Here, we test the hypothesis that Surfaxin® confers greater protection against ventilator/hyperoxia-induced lung inflammation than animal-derived SRT in preterm lambs with RDS. Design and Methods Preterm lambs (n = 24; 126.8±0.2 SE days gestation) were delivered ventilated (FIO2 = 1), randomized to SRT with Surfaxin® (175 mg/kg), Curosurf® (175 mg/kg), Survanta® (100 mg/kg), or no SRT (control) and studied for 4 hrs. Cardiopulmonary parameters were monitored. Lung tissue IL-8, IL-6, myeloperoxidase (MPO) and histomorphometry were measured. Results By 4 hrs, PaO2 and compliance in all SRT groups were greater (p Conclusions Surfaxin attenuated lung inflammation and preserved lung structure in preterm lambs with RDS more than either no SRT or SRT with animal-derived surfactant. To the degree that inflammation may lead to functional compromise and existing SRT formulations lack sufficient anti-inflammatory proteins, these data suggest that early intervention with Surfaxin may mitigate progression of RDS to bronchopulmonary dysplasia. Supported by: Discovery Laboratories, Inc.
Study of Neuromotor Reaction Times under the Influence of Thyrotropin-Releasing Hormone (1987)

Neuromotor reaction times (simple, choice, and decision) were measured when Thyrotropin-releasing hormone (TRH) was administered intravenously to nine healthy men in a double-blind study. Measurements were made of simple reaction time, choice reaction time, and decision time for each subject at various intervals over a 54-hr. period. Given the observed inherent interaction of the drug with the long time used (54 hr.), most analyses were conducted across separate time epochs. Injected subjects showed inhibition in the normal improvement of simple reaction time (which occurs with practice), and they reduced the time required to make a decision. Choice reaction time, however, remained unchanged across the drug-nondrug experimental conditions.
UTILITY OF INTRAOPERATIVE OPTICAL COHERENCE TOMOGRAPHY DURING VITRECTOMY SURGERY FOR VITREOMACULAR TRACTION SYNDROME (2014)

Intrasurgical imaging using iOCT during vitreomacular traction surgery may identify subclinical changes (e.g., occult full-thickness macular hole formation) that may impact surgical decision making. Architectural changes may occur after surgical maneuvers that are particularly noted in the outer retina. The functional significance of these changes requires further investigation.
Forced Expiratory Technique, Directed Cough, and Autogenic Drainage (2007)

In health, secretions produced in the respiratory tract are cleared by mucociliary transport, cephalad airflow bias, and cough. In disease, increased secretion viscosity and volume, dyskinesia of the cilia, and ineffective cough combine to reduce secretion clearance, leading to increased risk of infection. In obstructive lung disease these conditions are further complicated by early collapse of airways, due to airway compression, which traps both gas and secretions. Techniques have been developed to optimize expiratory flow and promote airway clearance. Directed cough, forced expiratory technique, active cycle of breathing, and autogenic drainage are all more effective than placebo and comparable in therapeutic effects to postural drainage; they require no special equipment or care-provider assistance for routine use. Researchers have suggested that standard chest physical therapy with active cycle of breathing and forced expiratory technique is more effective than chest physical therapy alone. Evidence-based reviews have suggested that, though successful adoption of techniques such as autogenic drainage may require greater control and training, patients with long-term secretion management problems should be taught as many of these techniques as they can master for adoption in their therapeutic routines.
Nonlinear boundary element method for two-dimensional magnetostatics (1984)

An interface formulation, successfully used for the solution of magnetostatic fields in piecewise homogeneous media, is extended to nonlinear media problems. The advantage of boundary integral techniques, in the reduction of problem dimensionality, is retained. This nonlinear boundary element method (BEM) algorithm alternates solution of the augmented interface equation with satisfaction of the constitutive media relations. Use of the M̄-B̄ chararteristics is shown to guarantee iteration stability because the slope approaches unity as μ tends to infinity. Isoparametric elements of second order are used for both geometry and sources to ensure high solution fidelity. Galerkin’s method is employed for discretization to matrix form. Each iteration requires only the product of the inverted system matrix with the augmented RHS. Examples include saturation of square and circular cylinders of high permeability in a uniform field. It is shown that with an optimal relaxation factor of 0.65, only 3–6 iterations are needed for convergence to 3% error tolerance in both magnetization and surface currents.
Optimized evolution in the cytostat: A Monte Carlo simulation (2008)

Rational genetic alterations of a microorganism for a specific purpose are not possible in many situations where our knowledge of the relationship between phenotype and genotype is limited. In such cases evolutionary techniques must be applied. Evolutionary methods are usually time consuming; therefore, more efficient techniques are highly desirable. In this work we present the optimization of strain development in a cytostat. The time required for mutant strain isolation is dependent on the total cells present, the wild-type specific growth rate, the beneficial mutation probability, the mutant specific growth rate, and several bioreactor operating conditions. These parameters are highly related, and a theoretical model, as developed here, is needed to define the conditions that optimize the isolation. The model is based on a discrete, stochastic description of mutant formation and selection in the background of abundant wild-type cells. Using the model, we determined the optimal cytostat operating strategy for mutant isolation that varies according to the probability of beneficial mutations. It is also shown that mutants with as little as a 5% growth advantage can be isolated in less than 15 days which is significantly faster than in a chemostat. The described optimal mutant isolation procedure is expected to be particularly useful for the generation of industrial strains that are robust in challenging growth conditions.
ChemInform Abstract: METHYL β‐GLYCOSIDES OF N‐ACETYL‐6‐O‐(Ω‐AMINOACYL)MURAMYL‐L‐ALANYL‐D‐ISOGLUTAMINES, AND THEIR CONJUGATES WITH MENINGOCOCCAL GROUP C POLYSACCHARIDE (1983)

Abstract Das Muramyldipeptid (I) wird mit verschiedenen langen, hydrophilen Spacer‐Armen wie (II) zu den 6‐O‐Acyl‐muramyldipeptiden wie (IVa) umgesetzt.
Proceedings of the 2015 ACM SIGMETRICS International Conference on Measurement and Modeling of Computer Systems (2015)

Welcome to SIGMETRICS 2015. SIGMETRICS is the flagship conference of the ACM special interest group for the computer systems performance evaluation community. This year marks the forty-second anniversary since SIGMETRICS (under its prior name, SIGME) held the First National SIGME Symposium on Measurement and Evaluation in 1973. The past four decades have seen enormous changes in the field of computer science, but the importance of measurement, modeling, and performance evaluation remains as critical as ever.

This year's conference includes papers on topics that have been a mainstay since the founding of our SIG, including queuing, scheduling, resource allocation, and performance measurement. Application areas that have emerged in recent years, such as data center and cloud, big data, solidstate storage, machine learning, crowdsourcing, energy optimization, continue to be represented in our program. We received 239 submissions to this year's conference, of which 32 appear in the program as full papers, which is a highly competitive acceptance ratio below 14%. An additional 24 submissions appear in the abbreviated form of poster presentations and extended abstracts.

As in some prior years, we performed reviews in three rounds. In the first round, each paper was assigned to three reviewers. In the second round, papers were up for discussion among the reviewers, especially those with highly divergent review opinions. In some cases, additional reviews were necessary to ensure that every paper would receive at least three reviews. Based on this and immediately prior to the TPC meeting, papers were bucketed into accept, reject, and at TPC buckets. Finally, in the TPC meeting at MIT (Cambridge, MA), we entertained comments and objections on papers in the accept and reject buckets and discuss all papers in the at TPC bucket.

It was no mean feat to winnow a set of nearly two hundred and fifty submissions down to a set of appropriate size for a three-day conference. We offer tremendous thanks to the 57 members of the program committee who collectively performed this daunting task. We are grateful for the support of the SIGMETRICS board during the lengthy process of selecting this year's conference program.
ChemInform Abstract: EPOXYANNULATION. 5. REACTIONS OF 1‐BUTADIENYL SULFONIUM SALTS (1983)

Abstract Cyclohexanon (I) reagiert mit dem Dienyl‐sulfoniumsalz (II) intermediär zu (III), aus dem das isolierbare Epoxid (IV) entsteht, das mit Lithiumalanat den Alkohol (V) ergibt, der zu (VI) hydriert wird.
Direct measurement of lateral transport in membranes by using time-resolved spatial photometry. (1985)

Spatially resolving light detectors allow, with proper calibration, quantitative analysis of the variations in two-dimensional intensity distributions over time. An ultrasensitive microfluorometer was assembled by using as a detector a microchannel plate-intensified video camera. The camera was interfaced with a software-based digital video analysis system to digitize, average, and process images and to directly control the timing of the experiments to minimize exposure of the specimen to light. The detector system has been characterized to allow its use as a photometer. A major application has been to perform fluorescence recovery after photobleaching measurements by using the camera in place of a photomultiplier tube (video-FRAP) with the goal of detecting possible anisotropic diffusion or convective flow. Analysis of the data on macromolecular diffusion in homogenous aqueous glycol solutions yielded diffusion constants in agreement with previous measurements. Results on lipid probe diffusion in dimyristoylphosphatidylcholine multibilayers indicated that at temperatures above the gel-to-liquid crystalline phase transition diffusion is isotropic, and analysis of video-FRAP data yielded diffusion coefficients consistent with those measured previously by using spot photobleaching. However, lipid probes in these multibilayers held just below the main phase transition temperature exhibited markedly anisotropic diffusive fluxes when the bleaching beam was positioned proximate to domain boundaries in the P beta' phase. Lipid probes and lectin receptor complexes diffused isotropically in fibroblast surface membranes with little evidence for diffusion channeled parallel to stress fibers. A second application was to trace the time evolution of cell surface reactions such as patching. The feasibility of following, on the optical scale, the growth of individual receptor clusters induced by the ligand wheat germ agglutinin was demonstrated.
Supplementary Table 3 from Tumor-Specific Isoform Switch of the Fibroblast Growth Factor Receptor 2 Underlies the Mesenchymal and Malignant Phenotypes of Clear Cell Renal Cell Carcinomas (2023)

&lt;p&gt;XLSX file - 12K, Predicted percentages of samples having FGFR2 IIIc as the major isoform in multiple cancers&lt;/p&gt;
Distributed suppression of stimulated Raman scattering in an Yb-doped filter-fiber amplifier (2006)

Suppression of stimulated Raman scattering (SRS) is demonstrated in a cladding-pumped fiber amplifier. The Yb-doped amplifier fiber design incorporates a high-index ring that resonantly couples SRS wavelengths out of the gain material, thus filtering the gain. Modeling shows that fiber asymmetry plays an important role in the filtering spectrum.
The efficacy of post porosity plasma protection against vacuum-ultraviolet damage in porous low-k materials (2015)

As of today, plasma damage remains as one of the main challenges to the reliable integration of porous low-k materials into microelectronic devices at the most aggressive node. One promising strategy to limit damage of porous low-k materials during plasma processing is an approach we refer to as post porosity plasma protection (P4). In this approach, the pores of the low-k material are filled with a sacrificial agent prior to any plasma treatment, greatly minimizing the total damage by limiting the physical interactions between plasma species and the low-k material. Interestingly, the contribution of the individual plasma species to the total plasma damage is not fully understood. In this study, we investigated the specific damaging effect of vacuum-ultraviolet (v-UV) photons on a highly porous, k = 2.0 low-k material and we assessed the P4 protective effect against them. It was found that the impact of the v-UV radiation varied depending upon the v-UV emission lines of the plasma. More importantly, we successfully demonstrated that the P4 process provides excellent protection against v-UV damage.
Time synchronization for ZigBee networks (2005)

Time synchronization is essential for most network applications. It is particularly important in a wireless sensor network (WSN) as a means to correlate diverse measurements from a set of distributed sensor elements and synchronize clocks for shared channel communication protocols. Wireless sensors are typically designed with very stringent constraints for size, cost, and especially power consumption. The flooding time synchronization protocol (FTSP) was developed explicitly for time synchronization of mesh-connected wireless sensor networks. However, ZigBee can also accommodate master-slave networks that can be more power-efficient. We optimized the FTSP for master-slave WSNs and implemented it using TinyOS 1.1.8 and ZigBee-compliant hardware. Our approach allows better synchronization and reduced power consumption of wireless nodes. In this paper we present implementation and experimental results.
An improved thin‐layer chromatography/mass spectrometry coupling using a surface sampling probe electrospray ion trap system (2004)

A combined surface sampling probe/electrospray emitter coupled with an ion trap mass spectrometer was used for the direct read out of unmodified reversed-phase C18 thin-layer chromatography (TLC) plates. The operation of the surface sampling electrospray ionization interface in positive and negative ionization modes was demonstrated through the direct analysis of TLC plates on which a commercial test mix comprised of four dye compounds viz., rhodamine B, fluorescein, naphthol blue black, and fast green FCF, and an extract of the caffeine-containing plant Ilex vomitoria, were spotted and developed. Acquisition of full-scan mass spectra and automated collection of MS/MS product ion spectra while scanning a development lane along the surface of a TLC plate demonstrated the advantages of using an ion trap in this combination. Details of the sampling system, benefits of analyzing a developed lane in both positive ion and negative ion modes, levels of detection while surface scanning, surface scan speed effects, and the utility of three-dimensional data display, are also discussed.
50Gb/s C-band GeSi Waveguide Electro-Absorption Modulator (2016)

We report C-band waveguide-integrated GeSi electro-absorption modulators with 3dB-bandwidth beyond 50GHz. The DC extinction ratio is 4.2±0.3dB with 4.4±0.6dB insertion loss and the dynamic extinction ratio is 3.0dB at 50Gb/s NRZ-OOK with a 2V swing.