gebhart/patrepeval huggingface dataset:
Intranasal mRNA nanoparticle vaccination induces prophylactic and therapeutic anti-tumor immunity (2014)

Direct in vivo administration of messenger RNA (mRNA) delivered in both naked and nanoparticle formats are actively investigated because the use of dendritic cells transfected ex vivo with mRNA for cancer therapy is expensive and needs significant infrastructure. Notably, intravenous and subcutaneous injections are the only routes of administration tested for mRNA nanoparticle tumor vaccination. In this report, we demonstrate that tumor immunity can be achieved via nasal administration of mRNA. Mice nasally immunized with mRNA delivered in nanoparticle format demonstrate delayed tumor progression in both prophylactic and therapeutic immunization models. The observed tumor immunity correlates with splenic antigen-specific CD8+ T cells and is achieved only when mRNA is delivered in nanoparticle but not in naked format. In conclusion, we demonstrate, as a proof-of-concept, a non-invasive approach to mRNA tumor vaccination, increasing its potential as a broadly applicable and off-the-shelf therapy for cancer treatment.
Preclinical Characterization of a Next-Generation Brain Permeable, Paradox Breaker BRAF Inhibitor (2021)

The novel BRAFi demonstrates preclinically the potential to outperform available targeted therapies for the treatment of BRAF-mutant tumors, thus supporting its clinical investigation.
Bis(2-methylquinolin-8-olato-κ2N,O)(6-phenyl-2-naphtholato-κO)aluminium(III) (2006)

The five-coordinate geometry of the Al atom in the title compound, [Al(C10H8NO)2(C16H11O)], is trigonal–bipyramidal, in which the O-donor atoms of the naphtholate and the two quinolinolate ligands are in the trigonal equatorial plane and the N atoms in the axial positions.
Immunothérapie des cancers au troisième millénaire (2020)

Après plus d’un siècle de vicissitudes, l’immunothérapie révolutionne le traitement du cancer. Après les anticorps monoclonaux dirigés contre les cellules tumorales, les anticorps « immunomodulateurs » démontrent leurs effets thérapeutiques dans des essais cliniques de phase II-III contre différentes tumeurs solides (mélanome, cancer du poumon, cancer du rein…). Le premier anticorps à avoir eu l’autorisation de mise sur le marché (AMM obtenue en 2011) est l’ipilimumab, inhibiteur d’un frein d’activation des lymphocytes T, actif contre le mélanome métastique. Les réponses cliniques observées concernent un sous-groupe de patients (de 15-20%) mais sont de longue durée (jusqu’à plusieurs années). La vaccination antitumorale avance avec un vaccin cellulaire autologue (à base de cellules dendritiques) également approuvé dans le cancer prostatique hormonorésistant indolent et se diversifie avec l’utilisation de longs peptides codant pour des mutations en présence d’adjuvants. L’immuno thérapie « adoptive » (transfert aux patients de lymphocytes T spécifi ques de la tumeur) montre aussi son effi cacité dans les essais de phase II contre certaines leucémies, sarcomes et mélanomes. Les virus oncolytiques font une percée en Phase II dans le mélanome et sont à l’étude dans des cancers rares (mésothéliomes, glioblastomes). Ce sont les premières étapes d’une véritable révolution dans la thérapie du cancer, qui aura des répercussions multiples dans d’autres pathologies, y compris inflammatoires et infectieuses. Cet ouvrage, premier dans la nouvelle collection « La cancérologie aujourd'hui », a pour objectif de rappeler les bases cellulaires et moléculaires de l’immunogénicité des cancers, de présenter les différentes stratégies d’immunomodulation antitumorale et de conclure sur les progrès médicaux déjà enregistrés dans le domaine et à espérer dans un futur proche. Les auteurs, Laurence Zitvogel, Dalil Hannani, François Martin sont trois experts de ce domaine en rapide évolution.
Selective Autoantibody Production against CCL3 Is Associated with Human Type 1 Diabetes Mellitus and Serves As a Novel Biomarker for Its Diagnosis (2009)

We have recently demonstrated that patients suffering from chronic autoimmune diseases develop an autoantibody response against key mediators that participate in the initiation and progression of these diseases. In this paper, we show that patients with type 1 diabetes mellitus (T1DM), but not those suffering from several other inflammatory autoimmune diseases, display a selective autoantibody titer to a single CC chemokine named CCL3. From the diagnostic point we show that this response could be used as a biomarker for diagnosis of T1DM, a disease that is currently diagnosed by autoantibodies to competitive anti-insulin Abs, islet cell Abs, and glutamic acid decarboxylase Abs. We show that our currently suggested biomarker is more reliable than each of the above alone, including diagnosis of T1DM at its preclinical stage, and could therefore be used as a novel way for diagnosis of T1DM. These Abs were found to be neutralizing Abs. It is possible, though hard to prove, that these Abs participate in the natural regulation of the human disease. Hence, it has previously been shown by others that selective neutralization of CCL3 suppresses T1DM in NOD mice. Theses results together with ours suggest CCL3 as a preferential target for therapy of T1DM.
Identification and Characterization of Vstm3 as an inhibitory member of the CD28 family (90.31) (2009)

Abstract Members of the B7-CD28 family play critical roles in the response of T cells. We have identified the transmembrane protein Vstm3 as a member of the CD28 family based on gene structure. It has two immunoreceptor tyrosine inhibitory motifs in its cytoplasmic domain and is expressed on NK cells and a subset of T cells. Antibodies against VSTM3 antagonize multiple aspects of T cell activation including proliferation and cytokine production indicating it plays an inhibitory role in T cell activation. We have also identified two counter-structures for this protein, the previously identified proteins CD155 and CD112, which are expressed on activated antigen presenting cells. CD155 and CD112 also bind to the activating receptor CD226 and hence this extended family of interacting proteins forms a network of molecules similar to the well characterized CD28-CTLA4-CD80-CD86 network. A soluble form of Vstm3 binds to CD155 and CD112 and disrupts their ability to trigger an activating response through CD226, and hence antagonizes immune responses in vitro and in vivo. On the other hand, an antibody that specifically blocks Vstm3 interaction with CD155 and CD112 tends to enhance T cell responses in vitro and in vivo. Finally, mice that lack Vstm3 are more sensitive to the development of autoimmune diseases. Our data indicate that this novel member of the CD28 family negatively regulates T cell responses.
Hypersensitivity Pneumonitis in Peat Moss Processing Plant Workers (1998)

A nonsmoking 54-yr-old man, employed in a peat moss packaging plant, developed dyspnea and recurrent fever. The diagnosis of hypersensitivity pneumonitis (HP) was made. Thirteen of 14 coworkers and 13 nonexposed control subjects were studied. Five workers were nonsmokers, two were minimal smokers, and six were smokers. HP was found in another subject. Monocillium sp. and Penicillium citreonigrum, 4.6 x 10(7) CFU/g, were found in the peat moss. Three nonsmokers, the two minimal smokers (including the subject with HP), and the index case had antibodies to these microorganisms; none of the six heavy smokers had antibodies. Serum TNF-alpha was higher in the workers than in the control subjects (0.930 +/- 0.177 versus 0. 350 +/- 0.076). Three of the four asymptomatic seropositive workers and two seronegative smokers were further evaluated. All three seropositive workers had normal lung functions and CT but they all had a lymphocytic alveolitis (30, 34, and 68% lymphocytes in their bronchoalveolar lavage [BAL]). The smokers had normal lung functions, CT, and percentage of BAL lymphocytes (3 and 13%). This study identified a previously unrecognized work environment that can lead to HP and documented a protective effect of smoking on the response to antigens.
A Broadband Continuous Class-FGaN MMIC PA Using Multi-Resonance Matching Network (2019)

In this paper, we present a design technique for broadband harmonic-tuned monolithic microwave integrated circuit (MMIC) power amplifiers (PAs). A multi-resonance harmonic matching network is proposed for the continuous class -F mode operation, featuring low loss and compact chip area for integrated PA realization. A design procedure is developed for this network, considering low quality factor and electromigration current density limitation of on-chip inductors. A proof-of-concept GaN MMIC PA, implemented in a 0.25-μm GaN-on-SiC technology, provides 33. 9-36.ldBm output power and 38-48% power-added efficiency (PAE) in the frequency band 4-6GHz. For a 64-QAM signal with 100 MHz modulation bandwidth and 8 dB peak-to-average power ratio (PAPR), at 5 GHz, the average output power of 30.2 dBm and average PAE of 32% are achieved, while the error vector magnitude (EVM) is -32dB.
O-Methylarenehydroxamates as ortho-lithiation directing groups. Titanium(III)-mediated conversion of O-methyl hydroxamates to primary amides (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTO-Methylarenehydroxamates as ortho-lithiation directing groups. Titanium(III)-mediated conversion of O-methyl hydroxamates to primary amidesLawrence E. Fisher, Joan M. Caroon, Jahangir, S. Russell Stabler, Scott Lundberg, and Joseph M. MuchowskiCite this: J. Org. Chem. 1993, 58, 14, 3643–3647Publication Date (Print):July 1, 1993Publication History Published online1 May 2002Published inissue 1 July 1993https://pubs.acs.org/doi/10.1021/jo00066a014https://doi.org/10.1021/jo00066a014research-articleACS PublicationsRequest reuse permissionsArticle Views1447Altmetric-Citations49LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
A multiplex-multicast scheme that improves system capacity of voice-over-IP on wireless LAN by 100% (2004)

Voice-over-IP (VoIP) is.an important application on the Internet. With the emergence of WLAN technology and its various advantages compared with the traditional wired LAN, it is fast becoming the "last-mile" of choice for the overall Internet infrastructure. This work considers the support of VoIP over 802.11b WLAN. We show that although the raw WLAN capacity can potentially support more than 500 VoIP sessions, various overheads bring this down to only 12 VoIP sessions when using GSM 6.10 codec. We propose a novel multiplexing scheme for VoIP which exploits multicasting over WLAN for the downlink VoIP traffic. This scheme can achieve nearly 100% improvement in system capacity. In addition, we present results showing that the delay and delay jitter introduced by the proposed scheme are small. We believe that the scheme can reduce the blocking probability of VoIP sessions in an enterprise WLAN significantly.
ChemInform Abstract: Perfluoroalkyl‐Thwarted Rearrangement of Quinol Esters. Formation of Catechol Derivatives via 1,3‐Migration of Acyloxyl Group. (1988)

Abstract The 4‐perfluoroalkyl‐4‐quinols (III) are prepared from benzoquinone (I) and the iodides (II) in the presence of methyllithium and lithium bromide.
Assessing and improving acoustic radiation force image quality using a 1.5-D transducer design (2012)

A 1.5-D transducer array was proposed to improve acoustic radiation force impulse (ARFI) imaging signal-to-noise ratio (SNRARFI) and image contrast relative to a conventional 1-D array. To predict performance gains from the proposed 1.5-D transducer array, an analytical model for SNRARFI upper bound was derived. The analytical model and 1.5-D ARFI array were validated using a finite element modelbased numerical simulation framework. The analytical model demonstrated good agreement with numerical results (correlation coefficient = 0.995), and simulated lesion images yielded a significant (2.92 dB; p < 0.001) improvement in contrast-tonoise ratio when rendered using the 1.5-D ARFI array.
Enhanced Sequestration of Chromium by Mechanochemically Silicified Microscale Zerovalent Iron: Role of the Silicate-Modified Surface (2023)

Remediation of chromium-contaminated groundwater remains a significant environmental challenge around the world. Herein, we synthesized silicified microscale zerovalent iron (Si-mZVIbm) using a mechanochemical method and demonstrated that the silicate modification could significantly improve the Cr(VI) removal efficiency (up to 37.5-fold) compared with its un-silicified counterpart. Results of atomic force microscopy, scanning transmission electron microscopy, and positron annihilation measurements revealed that silicate acted as a milling lubricant to boost strain within zerovalent iron particles, inducing more plastic deformation and surface defects. The defect-rich silicified surface accelerates the electron transfer and subsequent in situ generation of Fe(II). More importantly, the surface-modified silicate can act as a ligand to coordinate leached Fe(II) ions, thus strengthening the reduction of Cr(VI) via surface-bound Fe(II) and favoring subsequent co-precipitation of Cr(III) and Fe(III) species on Si-mZVIbm surfaces. During column experiments using real Cr-contaminated groundwater, Si-mZVIbm (4 wt % in sand) was able to reduce the Cr(VI) concentration from 2 to 0.05 mg L–1, the World Health Organization drinking water standard for up to 1720 bed volumes with an empty-bed contact time of 5.1 min. These results demonstrate the potential field applicability of Si-mZVIbm in real contaminated groundwater remediation.
SFINX: Straightforward Filtering Index for Affinity Purification–Mass Spectrometry Data Analysis (2015)

Affinity purification-mass spectrometry is one of the most common techniques for the analysis of protein-protein interactions, but inferring bona fide interactions from the resulting data sets remains notoriously difficult. We introduce SFINX, a Straightforward Filtering INdeX that identifies true-positive protein interactions in a fast, user-friendly, and highly accurate way. SFINX outperforms alternative techniques on two benchmark data sets and is available via the Web interface at http://sfinx.ugent.be/.
Analysis of Noise Uncertainty and Frequency Selectivity Effects in Wideband Multimode Spectrum Sensing (2014)

The present work is devoted to the comprehensive analysis of the detrimental effects of noise uncertainty in wide-band multimode subband based spectrum sensing over frequency selective channels. Unlike existing analyses that are mostly limited to single-band detection, an analytical model is firstly formulated for the case of wide-band multimode subband based spectrum sensing, considering both noise uncertainty and frequency selectivity. This model is also extended for the case of detecting a reappearing primary user (PU), as well as for the sensing scenarios where the frequency range of a PU is unknown. Novel closed-form expressions are derived for the corresponding probabilities of false alarm and probabilities of detection. The derived expressions are subsequently employed in quantifying the effects of noise uncertainty and frequency selectivity. A subband based scheme for the sensing of multi-channel primary systems is presented and analyzed. The proposed method is found to exhibit significantly reduced sensing time and greatly improved robustness against noise uncertainty compared to the basic wideband energy detection method.
DAGA: Data Augmentation with a Generation Approach for Low-resource Tagging Tasks (2020)

Bosheng Ding, Linlin Liu, Lidong Bing, Canasai Kruengkrai, Thien Hai Nguyen, Shafiq Joty, Luo Si, Chunyan Miao. Proceedings of the 2020 Conference on Empirical Methods in Natural Language Processing (EMNLP). 2020.
Towards tender X-rays with Zernike phase-contrast imaging of biological samples at 50 nm resolution (2014)

X-ray microscopy is a commonly used method especially in material science application, where the large penetration depth of X-rays is necessary for three-dimensional structural studies of thick specimens with high-Z elements. In this paper it is shown that full-field X-ray microscopy at 6.2 keV can be utilized for imaging of biological specimens with high resolution. A full-field Zernike phase-contrast microscope based on diffractive optics is used to study lipid droplet formation in hepatoma cells. It is shown that the contrast of the images is comparable with that of electron microscopy, and even better contrast at tender X-ray energies between 2.5 keV and 4 keV is expected.
Steady streaming near model cod otoliths (2008)

Typical fish distinguish sounds at about 10-1000 Hz with particle motions as small as 0.1 nm and angular separation near 10° using their ears, which contain dense, bony otoliths weakly suspended in endolymph and tissue. The otoliths oscillate relative to incident sound, inducing flows in the surrounding fluid which are in turn sensed by the hair cells on the overlying macular membrane which project into the groovelike sulcus on the otolith. These fluid flows are then sampled by the hair cells and ''heard'' by the fish. The irregular geometry of the otolith shapes the flow patterns. The hair cells, which are organized into different ciliary orientation groups on the macula, preferentially sample the flow patterns along their axes. The steady component of the fluid motion near enlarged models of an actual cod otolith oscillated at 2--20 Hz along different directions was studied in the vicinity of the hair cells using phase-locked particle-image velocimetry (PIV) and pathline visualizations. The possible relationship between the flow patterns and hearing capabilities is discussed. Although the oscillation amplitudes studied are much larger than those for underwater sound, evidence suggests that the flow patterns are amplitude independent. [Supported by ONR.]
Machine Learning-based Prediction for Dynamic, Runtime Architectural Optimizations of Embedded Systems (2019)

Embedded systems have been becoming increasingly complex over recent years, with performance becoming comparable to desktop computing systems. However, embedded systems need to adhere to greater design constraints (e.g., area and energy constraints) compared to desktop computing systems. Architectural specialization is a technique that can aid in meeting the stringent design constraints by introducing configurable hardware that can be tuned at runtime to optimize a goal (e.g., minimum energy, minimum execution time) for an application. However, traditional approaches (i.e., exhaustive, heuristic searches) often take considerable time to search a large design composed of different configurable parameters (e.g., cache size, associativity, etc.) and parameter values (e.g., 4 kB, 2-way, etc.). In addition, the presence of application phases (i.e., repeating execution behavior) allow for finer-grained tuning at the cost of even greater exploration overhead. In this paper, we apply machine learning to reduce/eliminate the design space exploration overhead associated with finding the best set of configurable parameters for configurable L1 instruction and data caches. Our prediction methodology consists of artificial neural networks (ANNs) which take the execution statistics of an application phase as input and outputs a best cache configuration (i.e., combination of configurable parameter values) for the instruction and data caches). Our results show that we can achieve an average energy degradation of less than 5% for the instruction and data caches with an average of 20% phase misclassification percentage and 20% less cache switches than the case where the best cache configuration is chosen for every application phase.
Inhibition of Endoplasmic Reticulum-Resident Glucosidases Impairs Severe Acute Respiratory Syndrome Coronavirus and Human Coronavirus NL63 Spike Protein-Mediated Entry by Altering the Glycan Processing of Angiotensin I-Converting Enzyme 2 (2014)

Endoplasmic reticulum (ER)-resident glucosidases I and II sequentially trim the three terminal glucose moieties on the N-linked glycans attached to nascent glycoproteins. These reactions are the first steps of N-linked glycan processing and are essential for proper folding and function of many glycoproteins. Because most of the viral envelope glycoproteins contain N-linked glycans, inhibition of ER glucosidases with derivatives of 1-deoxynojirimycin, i.e., iminosugars, efficiently disrupts the morphogenesis of a broad spectrum of enveloped viruses. However, like viral envelope proteins, the cellular receptors of many viruses are also glycoproteins. It is therefore possible that inhibition of ER glucosidases not only compromises virion production but also disrupts expression and function of viral receptors and thus inhibits virus entry into host cells. Indeed, we demonstrate here that iminosugar treatment altered the N-linked glycan structure of angiotensin I-converting enzyme 2 (ACE2), which did not affect its expression on the cell surface or its binding of the severe acute respiratory syndrome coronavirus (SARS-CoV) spike glycoprotein. However, alteration of N-linked glycans of ACE2 impaired its ability to support the transduction of SARS-CoV and human coronavirus NL63 (HCoV-NL63) spike glycoprotein-pseudotyped lentiviral particles by disruption of the viral envelope protein-triggered membrane fusion. Hence, in addition to reducing the production of infectious virions, inhibition of ER glucosidases also impairs the entry of selected viruses via a post-receptor-binding mechanism.
Transient alexia (letter-by-letter reading) after single photon emission computed tomography-verified selective left posterior cerebral artery sodium amytal injection (1996)

Alexia characterized by letter-by-letter reading is an acquired visual word-form dyslexia which has been observed after left posterior cerebral artery (PCA) territory infarcts. Typically, however, reading is not assessed in epilepsy surgery candidates who undergo left posterior cerebral artery sodium amytal (PSA) testing. We present clinical observations of three right-handed subjects who demonstrated transient alexia (letter-by-letter reading) when presented a compound word in the intact visual half-field during left PSA [with posterior left hemisphere amytal distribution verified by single photon emission computed tomography (SPECT)]. In all three cases, the sodium amytal effect persisted throughout language testing, as evidenced by hemianopia contralateral to the side of injection. In addition to alexia, two of the three subjects also demonstrated object naming failures to visual and tactile confrontation. Color naming, sentence repetition, serial speech, and auditory comprehension were preserved in all three cases; i.e., patients developed only one (anomia) or no other neighborhood signs. Although limited by the number of data points, this case series suggests that reading items might be beneficially incorporated into the PSA test. Whether the occurrence of dyslexia during dominant hemisphere PSA testing has predictive validity in identifying patients at risk for postoperative reading impairment remains to be investigated.