gebhart/patrepeval huggingface dataset:
NEUROTROPHINS AND THEIR RECEPTORS IN RAT PERIPHERAL TRIGEMINAL SYSTEM DURING MAXILLARY NERVE GROWTH (1993)

We examined the expression of the neurotrophins (NTFs) and their receptor mRNAs in the rat trigeminal ganglion and the first branchial arch before and at the time of maxillary nerve growth. The maxillary nerve appears first at embryonic day (E)10 and reaches the epithelium of the first branchial arch at E12, as revealed by anti-L1 immunohistochemistry. In situ hybridization demonstrates, that at E10-E11, neurotrophin-3 (NT-3) mRNA is expressed mainly in the mesenchyme, but neurotrophin-4 (NT-4) mRNA in the epithelium of the first branchial arch. NGF and brain-derived neurotrophic factor (BDNF) mRNAs start to be expressed in the distal part of the first brachial arch shortly before its innervation by the maxillary nerve. Trigeminal ganglia strongly express the mRNA of trkA at E10 and thereafter. The expression of mRNAs for low-affinity neurotrophin receptor (LANR), trkB, and trkC in trigeminal ganglia is weak at E10, but increases by E11-E12. NT-3, NT-4, and more prominently BDNF, induce neurite outgrowth from explant cultures of the E10 trigeminal ganglia but no neurites are induced by NGF, despite the expression of trkA. By E12, the neuritogenic potency of NGF also appears. The expression of NT-3 and NT-4 and their receptors in the trigeminal system prior to target field innervation suggests that these NTFs have also other functions than being the target-derived trophic factors.
Design of color screen sets for robustness to color plane misregistration (2011)

Periodic clustered-dot screens are widely used for electrophotographic printers due to their homogeneous halftone texture and their robustness to dot gain. However, when applied to color printing, there are two important phenomena that limit the quality of printed color halftones generated using a screening technology: (1) moire´ due to the superposition halftone patterns corresponding to different periodicity matrices, and (2) appearance changes due to misregistration between different colorant planes. This paper focuses on analyzing the registration sensitivity of periodic, clustered-dot screens. To quantitatively measure the effect of registration errors, we introduce two new functions: (1) cost, and (2) risk of registration errors. We propose the notion of “visual equivalence”, and derive three propositions under which visual equivalence can be achieved, even when registration errors occur.
Belief propagation for interacting quantum systems on sparse graphs (2007)

Belief propagation -- a powerful heuristic method to solve inference problems involving a large number of random variables -- was recently generalized to quantum theory. Like its classical counterpart, this algorithm is exact on trees when the appropriate independence conditions are met and is expected to provide reliable approximations when operated on loopy graphs. In this paper, we benchmark the performances of loopy quantum belief propagation (QBP) in the context of finite-tempereture quantum many-body physics. Our results indicate that QBP provides reliable estimates of the high-temperature correlation function when the typical loop size in the graph is large. As such, it is suitable e.g. for the study of quantum spin glasses on Bethe lattices and the decoding of sparse quantum error correction codes.
Differential Association between HER2/neu and Angiogenesis in Breast Cancer (2013)

The HER-2/neu oncogene encodes a transmembrane tyrosine kinase receptor and a member of the epidermal growth factor receptors (EGFR/ErbB) family. Over-expression of this oncogene is known to contribute to pathogenesis and aggressive progression in breast cancer. On the other hand, angiogenesis is a physiological process of forming new blood vessels from pre-existing ones; however it is essential for tumor growth and transitional from benign stage to malignant form and also fundamental process for metastasis of tumors. In this study the main aim was to investigate whether angiogenesis is the cause for increased aggressive behavior of HER2 overexpression subtype in breast cancer. A variety of approaches were employed to investigate the main aim: quantification of angiogenesis using a mouse cancer cells implanted model; Drabkin’s assay for hemoglobin measurement; morphology assessment of cell lines; Bio-Plex analysis of angiogenesis factors angiopoietin-2, follistatin, G-CSF, HGF, IL-8, Leptin, PDGF-BB, PECAM-1 and VEGF; and reverse transcriptase-PCR on VEGFA and HIF-1 alpha genes expression. The data from this study showed that the AU-565 cell line which over-expresses HER2 receptors showed a significant decrease in both tumor weight and hemoglobin measurement when the cells were treated with anti-HER2 implanted in nude mice. Also, the data showed an increased expression of angiogenic factors and genes (mainly VEGF, VEGFA, Angiopoietin, and IL-8) in AU-565 as compared to MCF-7 cells, which have low expression of HER2 receptors. This suggests that breast cancer with HER2/ neu oncogenes is associated with more angiogenic activities that result in an increased aggressive behavior of this form of cancer.
Design framework for the development of tailored behavior change technologies (2023)

Today, so-called persuasive or motivational technologies are developing, which refer to technologies, applications or services designed to induce changes in attitudes and behavior in those who use them. This is the subject of research in Human-Computer Interaction in connection with theories from psychology related, for example, to behavior change or motivation. Research on these technologies suggests that in order to encourage long-term adherence, these "virtual coaches" need to be personalized and/or tailored according to the individual characteristics of the users (stage of behavior change, motivations, preferences, barriers). For example, according to the Self-Determination Theory (SDT), an individual can present different forms of motivation, more or less effective. The idea is to be able to identify the forms of motivation present in users in order to propose services to reinforce or develop them. The use of such systems in the field of health has the potential to induce and reinforce health behaviors that are sometimes difficult to establish by health professionals. Providing daily, personalized care represents a considerable human and financial cost for health professionals. A mobile application has the advantage of being able to deal with these constraints. The computer coach is designed with and for patients suffering from chronic low back pain. The aim is to help them manage their condition, particularly with regard to their pain and the practice of regular physical activity. The work presented presents an innovative design approach, combining user-centered methodologies and psychological theories, which we detail through a research phase and a design phase. Currently, a first version of the application has been developed and is being tested.
Grouping of subcarriers and effective SNR statistics in wideband OFDM systems using EESM (2017)

This paper considers an orthogonal frequency division multiplexing system where the Effective Exponential SNR Mapping (EESM) is applied. We first present an approximate model in which the subcarriers grouped into one block are assumed to have the same channel coefficient and, subcarriers in different blocks have independent and identically distributed channel coefficients. Then, we present an algorithm based on a goodness of fit test to estimate the number of subcarriers to be grouped into one block. Building on this approximation model, we provide an approach to compute the statistics of the effective SNR obtained from the EESM mapping. This method is based on convolution technique. The approach presented in the paper is then validated through simulations.
WaterJet Technology in Penile Disassembly for m. Peyronie—the Ideal Tool for Worst Cases of Induratio Penis Plastica. (2002)

No AccessJournal of UrologyUROLOGICAL SURVEY: Video Reviews: SEXUAL DYSFUNCTION/DONOR NEPHRECTOMY/UROLOGIC COLLAGE1 Jan 2002WaterJet Technology in Penile Disassembly for m. Peyronie—the Ideal Tool for Worst Cases of Induratio Penis Plastica. Philip M. Hanno, andM.D. Ralph V. ClaymanM.D. Philip M. HannoPhilip M. Hanno More articles by this author , and Ralph V. ClaymanRalph V. Clayman More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)65491-2AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "WaterJet Technology in Penile Disassembly for m. Peyronie—the Ideal Tool for Worst Cases of Induratio Penis Plastica.." The Journal of Urology, 167(1), p. 439 © 2002 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 167Issue 1January 2002Page: 439 Advertisement Copyright & Permissions© 2002 by American Urological Association, Inc.MetricsAuthor Information Philip M. Hanno More articles by this author Ralph V. Clayman More articles by this author Expand All Advertisement Loading ...
The HI0073/HI0074 protein pair from Haemophilus influenzae is a member of a new nucleotidyltransferase family: Structure, sequence analyses, and solution studies (2002)

The crystal structure of HI0074 from Haemophilus influenzae, a protein of unknown function, has been determined at a resolution of 2.4 A. The molecules form an up-down, four-helix bundle, and associate into homodimers. The fold is most closely related to the substrate-binding domain of KNTase, yet the amino acid sequences of the two proteins exhibit no significant homology. Sequence analyses of completely and incompletely sequenced genomes reveal that the two adjacent genes, HI0074 and HI0073, and their close relatives comprise a new family of nucleotidyltransferases, with 15 members at the time of writing. The analyses also indicate that this is one of eight families of a large nucleotidyltransferase superfamily, whose members were identified based on the proximity of the nucleotide- and substrate-binding domains on the respective genomes. Both HI0073 and HI0074 were annotated "hypothetical" in the original genome sequencing publication. HI0073 was cloned, expressed, and purified, and was shown to form a complex with HI0074 by polyacrylamide gel electrophoresis under nondenaturing conditions, analytic size exclusion chromatography, and dynamic light scattering. Double- and single-stranded DNA binding assays showed no evidence of DNA binding to HI0074 or to HI0073/HI0074 complex despite the suggestive shape of the putative binding cleft formed by the HI0074 dimer.
Immersive Analytics Sensemaking on Different Platforms (2019)

In this work we investigated sensemaking activities on different immersive platforms. We observed user s during a classification task on a very large wall-display system (experiment I) and in a modern Virtual Reality headset (experiment II). In experiment II, we also evaluated a condition with a VR headset with an extended field of view, through a sparse peripheral display. We evaluated the results across the two studies by analyzing quantitative and qualitative data, such as task completion time, number of classifications, followed strategies, and shape of clusters. The results showed differences in user behaviors between the different immersive platforms, i.e., the very large display wall and the VR headset. Even though quantitative data showed no significant differences, qualitatively, users used additional strategies on the wall-display, which hints at a deeper level of sensemaking compared to a VR Headset. The qualitative and quantitative results of the comparison between VR Headsets do not indicate that users perform differently with a VR Headset with an extended field of view.
SP-0219: Green Journal (2016)

Introduction and purpose: Patients with head and neck cancer are treated with surgery, radiotherapy and chemotherapy either alone or in combination. The treatment has serious consequences for the patients, because of frequent and severe late side effects that often affects the patient's everyday life. The aim of the study was to investigate the unmet needs of the head and neck cancer survivors and to manage the late effect of the treatment. We wanted to investigate which health care efforts the patient needed in order to improve their quality of life.
Pushing the limits of self-supervised ResNets: Can we outperform supervised learning without labels on ImageNet? (2022)

Despite recent progress made by self-supervised methods in representation learning with residual networks, they still underperform supervised learning on the ImageNet classification benchmark, limiting their applicability in performance-critical settings. Building on prior theoretical insights from ReLIC [Mitrovic et al., 2021], we include additional inductive biases into self-supervised learning. We propose a new self-supervised representation learning method, ReLICv2, which combines an explicit invariance loss with a contrastive objective over a varied set of appropriately constructed data views to avoid learning spurious correlations and obtain more informative representations. ReLICv2 achieves $77.1\%$ top-$1$ accuracy on ImageNet under linear evaluation on a ResNet50, thus improving the previous state-of-the-art by absolute $+1.5\%$; on larger ResNet models, ReLICv2 achieves up to $80.6\%$ outperforming previous self-supervised approaches with margins up to $+2.3\%$. Most notably, ReLICv2 is the first unsupervised representation learning method to consistently outperform the supervised baseline in a like-for-like comparison over a range of ResNet architectures. Using ReLICv2, we also learn more robust and transferable representations that generalize better out-of-distribution than previous work, both on image classification and semantic segmentation. Finally, we show that despite using ResNet encoders, ReLICv2 is comparable to state-of-the-art self-supervised vision transformers.
Association of polygenic score for major depression with response to lithium in patients with bipolar disorder (2020)

Lithium is a first-line medication for bipolar disorder (BD), but only one in three patients respond optimally to the drug. Since evidence shows a strong clinical and genetic overlap between depression and bipolar disorder, we investigated whether a polygenic susceptibility to major depression is associated with response to lithium treatment in patients with BD. Weighted polygenic scores (PGSs) were computed for major depression (MD) at different GWAS p value thresholds using genetic data obtained from 2586 bipolar patients who received lithium treatment and took part in the Consortium on Lithium Genetics (ConLi<sup>+</sup>Gen) study. Summary statistics from genome-wide association studies in MD (135,458 cases and 344,901 controls) from the Psychiatric Genomics Consortium (PGC) were used for PGS weighting. Response to lithium treatment was defined by continuous scores and categorical outcome (responders versus non-responders) using measurements on the Alda scale. Associations between PGSs of MD and lithium treatment response were assessed using a linear and binary logistic regression modeling for the continuous and categorical outcomes, respectively. The analysis was performed for the entire cohort, and for European and Asian sub-samples. The PGSs for MD were significantly associated with lithium treatment response in multi-ethnic, European or Asian populations, at various p value thresholds. Bipolar patients with a low polygenic load for MD were more likely to respond well to lithium, compared to those patients with high polygenic load [lowest vs highest PGS quartiles, multi-ethnic sample: OR = 1.54 (95% CI: 1.18-2.01) and European sample: OR = 1.75 (95% CI: 1.30-2.36)]. While our analysis in the Asian sample found equivalent effect size in the same direction: OR = 1.71 (95% CI: 0.61-4.90), this was not statistically significant. Using PGS decile comparison, we found a similar trend of association between a high genetic loading for MD and lower response to lithium. Our findings underscore the genetic contribution to lithium response in BD and support the emerging concept of a lithium-responsive biotype in BD.
Supplementary Figures 1 - 3 from Regression of Metastatic Merkel Cell Carcinoma Following Transfer of Polyomavirus-Specific T Cells and Therapies Capable of Reinducing HLA Class-I (2023)

&lt;p&gt;PDF file - 738K, Supplementary Fig. S1: Detection of MCPyV-specific CD8 T cells among tumor infiltrating lymphocytes (TIL) from the primary MCC tumor (left) and PBMC (right). Cells were stained with A24/MCPyV.LT.92-101 tetramer and CD8. Supplementary Fig. S2: A) Cell products destined for infusions 1, 2 and 3 bound the MCPyV LT-Ag92-101 peptide-HLA tetramer. B) Products secreted IFNγ (left) and lysed MCPyV LT-Ag92-101 -pulsed FUJI (A24+ cell line) and autologous PBMC pulsed with 10?g/ml peptide (right). The product used for infusion 1 is shown and is representative. Supplementary Fig. S3: Assessment of CD25hiCD127loCD4+ T-cells in PBMC collected at baseline (137 days and immediately prior to the first treatment) and at indicated timepoints after treatments. Gray bars on x-axis indicate the timing of each treatment as detailed in Figure 1.&lt;/p&gt;
Vapor-phase conversion of aqueous 3-hydroxybutyric acid and crotonic acid to propylene over solid acid catalysts (2021)

Vapor phase conversion of 3-hydroxybutyric and crotonic acid to propylene in a continuous-flow reactor over silica–alumina and niobium catalysts demonstrates a new strategy for producing renewable fuels and chemicals from wastewater carbon.
SHP2 drives inflammation-triggered insulin resistance by reshaping tissue macrophage populations (2021)

Insulin resistance is a key event in type 2 diabetes onset and a major comorbidity of obesity. It results from a combination of fat excess-triggered defects, including lipotoxicity and metaflammation, but the causal mechanisms remain difficult to identify. Here, we report that hyperactivation of the tyrosine phosphatase SHP2 found in Noonan syndrome (NS) led to an unsuspected insulin resistance profile uncoupled from altered lipid management (for example, obesity or ectopic lipid deposits) in both patients and mice. Functional exploration of an NS mouse model revealed this insulin resistance phenotype correlated with constitutive inflammation of tissues involved in the regulation of glucose metabolism. Bone marrow transplantation and macrophage depletion improved glucose homeostasis and decreased metaflammation in the mice, highlighting a key role of macrophages. In-depth analysis of bone marrow-derived macrophages in vitro and liver macrophages showed that hyperactive SHP2 promoted a proinflammatory phenotype, modified resident macrophage homeostasis, and triggered monocyte infiltration. Consistent with a role of SHP2 in promoting inflammation-driven insulin resistance, pharmaceutical SHP2 inhibition in obese diabetic mice improved insulin sensitivity even better than conventional antidiabetic molecules by specifically reducing metaflammation and alleviating macrophage activation. Together, these results reveal that SHP2 hyperactivation leads to inflammation-triggered metabolic impairments and highlight the therapeutical potential of SHP2 inhibition to ameliorate insulin resistance.
Perceptive sorting (2003)

Products engender complex experiences that go far beyond aesthetics and ease of use. We believe that by better understanding people's functional and emotional relationships to existing products, we might better understand how to design future products. This paper presents the Perceptive Sorting exercise (PS), a method inspired by the field of visual research to gain responses to product familiarity, product function, and aesthetic considerations. We report on a study using the PS with coffeemakers, watches, and consumer robotic products. The results provided information about how participants assess product attributes, assign value, and tell stories of product use.
Erythropoietin production. A potential marker for interleukin-2/interferon-responsive tumors (1993)

These results contrast with those achieved with IL-2 alone or in combination with lymphokine-activated killer cells, for which a 15% response rate was seen in patients with renal cell cancer and polycythemia. Although less than 5% of renal cell tumors produce erythropoietin, its production may identify a subset of individuals with renal cell cancer responsive to IL-2 and alpha-IFN.
AI-Driven Assurance of Hardware IP against Reverse Engineering Attacks (2022)

The modern horizontal semiconductor supply chain has introduced a plethora of security threats targeting the integrity and confidentiality of hardware intellectual properties (IPs) and integrated circuits (ICs). Threats, such as reverse engineering, cloning, tampering, extraction of design intent have given rise to serious concerns for both the user and the producer of microelectronic devices. Logic locking, a recently proposed methodology, aims to defend against some of these threats through strategic logic gate insertions (key gates) and structural modifications. However, we observed that most existing logic locking techniques are vulnerable to structural analysis attacks. Furthermore, there is no technique available to quantify the robustness against structural analysis attacks of logic locking techniques. Based on these observations, we have developed a set of artificial intelligence guided evaluation frameworks and metrics to identify structural (SAIL, SIVA) and joint structural-functional (SURF) vulnerabilities in locked designs and quantify them. We have also developed a learning-guided logic locking framework, LeGO, that iteratively hardens a design against a set of known attacks with the possibility of expanding this attack database over time as new attacks are discovered. SAIL, SURF, and SIVA have opened up a new research area on structural attack vulnerability analysis of logic locking, while LeGO serves as a building block for developing the next generation of AI-guided logic locking techniques.
Dynamic Thin Films in Controlling the Fabrication of Nanocarbon and Its Composites (2017)

Thin film microfluidics are developed for a wide range of applications, including the synthesis of various types of nanocarbon material, involving both ‘top down’ and ‘bottom up’ continuous flow processing. This type of processing addresses scalability at the inception of the science, and is applicable not just to the synthesis of nanocarbon, but also composites or hybrid material where one or more components is nanocarbon. This review introduces the different types of thin film microfluidics where the liquid is subjected to shear stress (mechanical energy), and then provides a comprehensive treatise of controlling the fabrication of nanocarbon. The shear stress offers scope for controlling the shape, morphology and size of carbon nanomaterial, with the prospect of high green chemistry metrics of the processing. The use of thin film microfluidics has potential where conventional batch processing is limited in terms of practical convenience, and indeed where some novel forms of carbon and composites thereof are not accessible using traditional approaches.