gebhart/patrepeval huggingface dataset:
Time delay analysis in teleoperation system (2003)

We classify the data class according to their characteristics and endow with corresponding priority. To reduce time delay in teleoperation system, a dynamic scheduling policy is adopted. The dynamic scheduling policy processes high priority classes first, and then services low priority classes. The classes having low priority can be served in later sampling interval. It is important to maintain sampling interval to be consistent for stable operation of robot controller. In this paper, we analyze data traffic in teleoperation system and suggest the algorithm to control it. Through real experiment, we show the validity of this policy.
Microbiota profiles and dynamics in fermented plant‐based products and preliminary assessment of their in vitro gut microbiota modulation (2021)

Abstract Consumption of fermented food has long been associated with health benefits, but there is still limited knowledge on the bacterial dynamics in plant‐based food fermentation outside of culture‐based studies. Different fermented plant‐based products were assessed for the presence of Archaea and their microbiota bacterial dynamics during the fermentation. Archaea were consistently detected in the brine of the vegetables, and constant increase in gene copy number throughout the fermentation of kraut indicated that Archaea were not only viable but actively growing. The plant‐associated bacterial microbiota of cabbage and jalapeno were dominated by Proteobacteria, specifically Pseudomonas (51% and 39% respectively), while the okra harbored roughly equal numbers of firmicutes and proteobacteria. In cabbage and jalapeno fermentations, lactic acid bacteria (LAB), which were detected in extremely low levels in raw products, became dominant with expected succession of heterofermentative and homofermentative species. These two stages were not detected in the fermentation of okra, and Lactobacillus remained the most abundant genera. The kombucha fermentation was dominated by Gluconacetobacter as reported previously, but also characterized by high abundance of Bacteroides . Intriguingly, the microbiota composition and dynamics were very different between the two kombucha batches tested, suggesting redundancy in microorganisms’ fermentative roles. Finally, a preliminary in vitro fermentation study was indicative of a potential bifidogenic effect of microbial metabolites from kombucha. Collectively, these data indicate that fermented plant products harbor a highly diverse microbiota, bacteria, and archaea, even after the end of the fermentation.
Covalently Linked Heterobimetallic Catalysts for Olefin Polymerization (2004)

This contribution describes the synthesis and polymerization characteristics of the covalently linked heterobinuclear constrained-geometry polymerization catalyst (μ-CH2CH2-3,3‘){(η5-indenyl)[1-Me2Si(tBuN)](TiMe2)}{(η5-indenyl)[1-Me2Si(tBuN)](ZrMe2)} (Ti1Zr1). When activated with Ph3C+B(C6F5)-4, itis competent to produce long-chain (≥C6) branched polyethylenes in ethylene homopolymerization, in sharp contrast to control experiments with mixtures of analogous but mononuclear Zr and Ti CGC catalysts.
Adhesion of Exogenous Human Microglia and THP-1 Cells to Amyloid Plaques of Postmortem Alzheimer's Disease Brain (2008)

Microglial phagocytosis of amyloid-beta (Abeta) deposits is involved in Abeta clearance in vivo. To explore the ability of microglia to phagocytose beta, we cultured human microglia or human monocytic THP-1 cells directly on unfixed frontal cortex sections of an Alzheimer disease (AD) case. We found that when these cells were activated by lipopolysaccharide (LPS) plus interferon (IFN)-gamma, they developed ameboid morphology and formed clusters around and attaching to amyloid plaques in the tissue. Some cells adhering to these plaques internalized Abeta and some appeared to be degraded. Nevertheless, no significant reduction of the overall Abeta burden was observed. If the cells were not stimulated, they adhered poorly to the sections. We quantified THP-1 cell adhesion to an AD brain section compared with a normal brain section and found it to be significantly increased. If a brain section was rinsed with phosphate buffered saline containing 0.1% Triton X-100, most LPS/IFN-gamma-activated THP-1 cells failed to adhere. However, in co-culture with human astrocytes, the number of adherent THP-1 cells was significantly increased. These results suggest that human microglial cells are capable of adhering to and phagocytosing post mortem AD plaque material but activation may be necessary. Astrocytes may further enhance the process.
GPS III Accuracy and Integrity Improvements Using ARAIM with Shorter Age of Data (2014)

Advanced RAIM, or ARAIM, extends and improves upon traditional RAIM algorithm to detect and mitigate independent, multiple, and correlated GPS signal faults. A key input to ARAIM is the assumed user range error caused by satellite imperfections such as clock and ephemeris errors. In analyses done to date, estimates of one-sigma nominal errors (URE) and one-sigma error bounds (URA) are treated as fixed, whereas in reality, they vary with the age of data (AoD) of the clock and ephemeris navigation data broadcast by each satellite. Today's GPS satellites are normally uploaded with new data every 24 hours, and as this data ages, it becomes less representative of the current satellite status. Thus, satellite errors tend to grow predictably with age of data.

In this paper, ARAIM simulations for the future GPS III satellite constellation are conducted with AoD as a modeled parameter, and satellite errors are adjusted based upon it. AoD is computed from estimated upload times based on when each satellite passes over the GPS Master Control Segment (MCS) site at Schriever AFB in Colorado Springs, CO (i.e., one upload per satellite per day). The results of these simulations are similar to those obtained previously for GPS III satellites, which show a large performance improvement over today’s mix of Block II satellites. Variations in performance are caused by the increase in URA with age of data beyond what was considered in previous results. In particular, locations near Colorado Springs have generally lower AoD and perform somewhat better than before, while locations far away have longer AoD and perform somewhat worse.

In addition, simulations were run in which AoD was reduced by implementing three uploads per satellite per day and by providing an external source of navigation data such that AoD never exceeds 1 hour. One subcase also provides actual URA values instead of the conservative integers broadcast by the satellites. As expected, these changes further improve GPS III ARAIM performance. Locations with relatively long AoD tend to improve most when switching from one to three uploads per day, while locations with short AoD improve most with 1 hour AoD (externally provided) and knowledge of actual URA values.
High-speed axially swept light sheet microscopy using a linear MEMS phased array for isotropic resolution (2020)

Use of PAs is compatible with axially swept light sheet microscopy and offers significant improvements in speed.
Activated clotting times in acute coronary syndromes and percutaneous transluminal coronary angioplasty (1995)

A discrete fall in the ACT (activated coagulation time) has been observed in patients with known activation of the coagulation cascade. Injury to the coronary artery resulting in thrombin activation, whether spontaneous as in the case of acute myocardial infarction or planned as with percutaneous transluminal coronary angioplasty (PTCA), may therefore be reflected in a change in ACT values. We reviewed the records of patients undergoing PTCA at St. Luke's Episcopal Hospital/Texas Heart Institute from January 1990 through December 1992 for information regarding ACT values and clinical events. A total of 469 patients, whose record contained adequate information for study inclusion, were divided into four separate groups: acute myocardial infarction (group I, n = 62), unstable angina with heparin therapy that was withdrawn at least 4 hr prior to PTCA (group II, n = 102), unstable angina with heparin therapy continued until the time of PTCA (group III, n = 154), and stable angina undergoing elective PTCA (group IV, n = 151). Heparin was discontinued 12-15 hr after the procedure in all but group I where anticoagulation was often maintained up to 72 hr. ACT values were measured prior to the PTCA procedure (baseline), after the initial heparin bolus of 10,000 U (postheparin) and approximately 12-18 hr after the procedure (heparin withdrawal).(ABSTRACT TRUNCATED AT 250 WORDS)
Sonochemical activation of hematoporphyrin: a potential modality for cancer treatment (2003)

In-vitro and in-vivo studies demonstrate the antitumor effect of hematoporphyrin sonochemically activated by ultrasound irradiation. Tumor cell suspensions with and without hematoporphyrin (Hp) are irradiated by continuous-wave ultrasound. Ultrasound cell damage with Hp is significantly greater than that without Hp, while no cell damage by Hp alone was detected. Growth of tumors implanted in mice is stopped by the ultrasound irradiation after Hp administration. Because the cell-damage enhancement by Hp is suppressed by adding histidine to the suspension but not by adding mannitol, the enhancement is most likely due to sonochemical generation of singlet oxygen.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Continuous‐Flow Synthesis of 1‐Substituted Benzotriazoles from Chloronitrobenzenes and Amines in a CN Bond Formation/Hydrogenation/Diazotization/Cyclization Sequence (2013)

Zwei Ansätze wurden für die regiospezifische Synthese 1-substituierter Benzotriazole unter kontinuierlichen Fließbedingungen entwickelt. Sie beginnen entweder mit einer SNAr-Reaktion bei hoher Temperatur oder einer Pd-Katalyse und umfassen anschließende Multiphasen-Prozesse, die die effiziente mehrstufige Synthese von Benzotriazolen ermöglichen (siehe Bild). As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Effect of angiotensin-induced hypertension on rat coronary arteries and myocardium. (1976)

Acute hypertension has been produced in rats by the intravenous infusion of angiotensin amide for 4 hours. Both control and hypertensive animals were injected intravenously prior to sacrifice with either horseradish peroxidase (HRP) or colloidal carbon. Epicardial arteries and blocks of ventricular myocardium containing intramyocardial arteries and arterioles have been processed for electron microscopy. HRP appears to penetrate the endoethelium of epicardial arteries from control animals within vesicles that bypass endothelial junctions and empty into interendoethelial clefts. Peroxidase does not traverse the endothelium of intramural arteries and arterioles of controls over the 10-minute period of observation. There is acceleration of lateral vesicular transport in the endothelium of epicardial arteries after angiotensin infusion and direct permeation of interendothelial clefts of intramural arterial vessels. Medial fragmentation and more extensive necrosis are observed in intramyocardial but not in epicardial arterial vessels. Foci of myocardial damage resembling irreversible ischemic or anoxic injury followed by reflow are described. It is suggested that the increased permeability of epicardial arteries may be due to elevated pressure, while the altered permeability and vascular lesions of intramural arteries and arterioles are more readily attributable to the vasoconstriction produced by angiotension. The vascular and myocardial lesions are also discussed in relation to the regional actions of angiotensin on the coronary circulation and known effects of this vasoactive peptide on myocardium.
Effects of tabtoxinine-. beta. -lactam treatments on alfalfa (1991)

Tabtoxinine-{beta}-lactam (T{beta}L), excreted by the tobacco pathogen Pseudomonas syringae pv. tabaci, is an active site directed, irreversible inhibitor of the enzyme glutamine synthetase (GS) (E.C.6.3.2.1). Previously, we have shown infestation of the alfalfa rhizosphere with Pseudomonas syringae pv. tabaci results in selective impairment of GS and increased plant growth and nodule number. We have now shown purified T{beta}L, when administered to alfalfa roots, can produce the same effects as colonization of the rhizosphere with P. syringae pv. tabaci. Results of GS specific activity, nitrogen fixation as measured by acetylene reduction, and plant growth response to T{beta}L dosage are presented.
Functional loss of DHRS7C induces intracellular Ca2+ overload and myotube enlargement in C2C12 cells via calpain activation (2016)

Dehydrogenase/reductase member 7C (DHRS7C) is a newly identified NAD/NADH-dependent dehydrogenase that is expressed in cardiac and skeletal muscle and localized in the endoplasmic/sarcoplasmic reticulum (ER/SR). However, its functional role in muscle cells remains to be fully elucidated. Here, we investigated the role of DHRS7C by analyzing mouse C2C12 myoblasts deficient in DHRS7C (DHRS7C-KO cells), overexpressing wild-type DHRS7C (DHRS7C-WT cells), or expressing mutant DHRS7C [DHRS7C-Y191F or DHRS7C-K195Q cells, harboring point mutations in the NAD/NADH-dependent dehydrogenase catalytic core domain (YXXXK)]. DHRS7C expression was induced as C2C12 myoblasts differentiated into mature myotubes, whereas DHRS7C-KO myotubes exhibited enlarged cellular morphology after differentiation. Notably, both DHRS7C-Y191F and DHRS7C-K195Q cells also showed similar enlarged cellular morphology, suggesting that the NAD/NADH-dependent dehydrogenase catalytic core domain is pivotal for DHRS7C function. In DHRS7C-KO, DHRS7C-Y191F, and DHRS7C-K195Q cells, the resting level of cytosolic Ca<sup>2+</sup> and total amount of Ca<sup>2+</sup> storage in the ER/SR were significantly higher than those in control C2C12 and DHRS7C-WT cells after differentiation. Additionally, Ca<sup>2+</sup> release from the ER/SR induced by thapsigargin and 4-chloro-m-cresol was augmented in these cells and calpain, a calcium-dependent protease, was significantly activated in DHRS7C-KO, DHRS7C-Y191F, and DHRS7C-K195Q myotubes, consistent with the higher resting level of cytosolic Ca<sup>2+</sup> concentration and enlarged morphology after differentiation. Furthermore, treatment with a calpain inhibitor abolished the enlarged cellular morphology. Taken together, our findings suggested that DHRS7C maintains intracellular Ca<sup>2+</sup> homeostasis involving the ER/SR and that functional loss of DHRS7C leads to Ca<sup>2+</sup> overload in the cytosol and ER/SR, resulting in enlarged cellular morphology via calpain activation.
Solutions for 400 Gbit/s Inter Data Center WDM Transmission (2020)

We review some currently discussed solutions for 400 Gbit/s inter-data center WDM transmission for up to 100 km. We focus on direct detected solutions, namely PAM4 and DMT, and present two WDM systems based on these formats.
Recent technological advances in thin film devices based on topological insulators (2015)

Recent technological advances in thin film devices based on topological insulators ○塚﨑 敦 1,2、吉見 龍太郎 3、ジョセフ チェケルスキー4、安田 憲司 3 、小塚 裕 介 3,5 、ジョセフ ファルソン 3,5、高橋 圭 6、永長 直人 3,6、川﨑 雅司 3.5.6 、十 倉 好紀 3,6 (1.東北大金研、2.JST さきがけ、3.東大物工、4.MIT、5.東大 QPEC、6. 理研 CEMS) Atsushi Tsukazaki, Ryutaro Yoshimi, Joseph Checkelsky, Kenji Yasuda, Yusuke Kozuka, Joseph Falson, Kei Takahashi, Naoto Nagaosa, Masashi Kawasaki, Yoshinori Tokura (1. IMR, Tohoku Univ. , 2. JST-PRESTO, 3. Dept. Appl. Phys., The Univ. of Tokyo, 4. MIT, 5. QPEC, The Univ. of Tokyo, 6. RIKEN CEMS) E-mail: tsukazaki@imr.tohoku.ac.jp
Activation Mechanism of the Human Histamine H4 Receptor - An Explicit Membrane Molecular Dynamics Simulation Study (2008)

Molecular dynamics (MD) simulations in a membrane-embedded environment were carried out on the homology model of the human histamine H4 receptor (hH4R) alone and in complex with its endogenous activator histamine and with the first reported selective hH4R antagonist JNJ7777120. During the simulation of the histamine-hH4R complex, considerable changes occurred in the hH4R structure as well as in the interaction pattern of histamine at the binding site. These changes are in agreement with experimental data published on GPCR activation. In particular, the intracellular side of TM helix VI moved significantly away from TM helices III and VII. Moreover, histamine formed an interaction with Asn147 (4.57) that was previously proved to be important in hH4R activation. Results of the MD simulations of the native hH4R and the JNJ7777120-hH4R complex suggest that these models represent an inactive conformation of hH4R. MD simulation in the presence of JNJ7777120 resulted in the movement of the intracellular side of TM helix VI in the direction of TM helix III. Snapshots of the simulations may serve as functionally relevant models in the development of novel hH4R ligands in the future.
Peripheral Nerve Stimulators for Pain Control (2001)

Peripheral nerve stimulation (PNS) is a useful method for managing chronic intractable neuropathic pain in the extremities. The technique is theorized to work by blocking the pain signals via the gate mechanism of pain. Patients should have completed nonoperative treatment including oral and topical medications, transcutaneous electrical nerve stimulation (TENS), unit trial, desensitization, and possibly a less invasive surgical procedure prior to being considered for PNS. PNS is considered as a first choice over spinal cord stimulation (SCS) when there is an isolated distal nerve injury or when SCS is contraindicated or refused by the patient. When SCS has failed to provide adequate coverage of the patient's pain as determined by the lack of paresthesia in the affected zone, or if the coverage is inconsistent, PNS is a reasonable second alternative. The surgery can be performed as a two-stage operation or as a one-stage operation with an intraoperative wake-up test. There are complications associated with an electrical implant in the body, including battery, wire, and electrode problems. Overall, with proper patient selection and good technique, the benefit of PNS outweighs the risks.
A three-dimensional model of the human blood-brain barrier to analyse the transport of nanoparticles and astrocyte/endothelial interactions (2015)

The aim of this study was to develop a three-dimensional (3D) model of the human blood-brain barrier in vitro, which mimics the cellular architecture of the CNS and could be used to analyse the delivery of nanoparticles to cells of the CNS. The model includes human astrocytes set in a collagen gel, which is overlaid by a monolayer of human brain endothelium (hCMEC/D3 cell line). The model was characterised by transmission electron microscopy (TEM), immunofluorescence microscopy and flow cytometry. A collagenase digestion method could recover the two cell types separately at 92-96% purity. Astrocytes grown in the gel matrix do not divide and they have reduced expression of aquaporin-4 and the endothelin receptor, type B compared to two-dimensional cultures, but maintain their expression of glial fibrillary acidic protein. The effects of conditioned media from these astrocytes on the barrier phenotype of the endothelium was compared with media from astrocytes grown conventionally on a two-dimensional (2D) substratum. Both induce the expression of tight junction proteins zonula occludens-1 and claudin-5 in hCMEC/D3 cells, but there was no difference between the induced expression levels by the two media. The model has been used to assess the transport of glucose-coated 4nm gold nanoparticles and for leukocyte migration. TEM was used to trace and quantitate the movement of the nanoparticles across the endothelium and into the astrocytes. This blood-brain barrier model is very suitable for assessing delivery of nanoparticles and larger biomolecules to cells of the CNS, following transport across the endothelium.
Content Caching and Distribution in Smart Grid Enabled Wireless Networks (2016)

To facilitate wireless transmission of multimedia content to mobile users, we propose a content caching and distribution framework for smart grid enabled OFDM networks, where each popular multimedia file is coded and distributively stored in multiple energy harvesting enabled serving nodes (SNs), and the green energy distributively harvested by SNs can be shared with each other through the smart grid. The distributive caching, green energy sharing and the on-grid energy backup have improved the reliability and performance of the wireless multimedia downloading process. To minimize the total on-grid power consumption of the whole network, while guaranteeing that each user can retrieve the whole content, the user association scheme is jointly designed with consideration of resource allocation, including subchannel assignment, power allocation and power flow among nodes, where the user association scheme decides which SN serves which user. First, the optimal power allocated to each subchannel and the power flows among nodes are derived analytically. Then, the user association problem is decoupled from the subchannel assignment problem, and the proposed user association scheme has leveraged the multicasting nature of the content download process. To decide which subchannel is assigned to which node, the number of subchannels assigned to each node is first determined, according to the green energy generating rate and the associated traffic offload, and then the corresponding subchannels are selected from the total assigned system spectrum. Simulation results demonstrate that bringing content, green energy and serving node closer to the end user can notably reduce the on-grid energy consumption.
A specific anti‐COVID‐19 BNT162b2 vaccine‐induced early innate immune signature positively correlates with the humoral protective response in healthy and multiple sclerosis vaccine recipients (2023)

Overall, this study suggests that the vaccine-induced early regulation of innate immunity is mediated by IFN signalling, impacts on the magnitude of adaptive responses and it might be indicative of vaccine-induced humoral protection.