gebhart/patrepeval huggingface dataset:
Cfd Analysis On Aerodynamic Design Optimization Of Wind Turbine Rotor Blades (2009)

Wind energy has been shown to be one of the most viable sources of renewable energy. With current technology, the low cost of wind energy is competitive with more conventional sources of energy such as coal. Most blades available for commercial grade wind turbines incorporate a straight span-wise profile and airfoil shaped cross sections. These blades are found to be very efficient at lower wind speeds in comparison to the potential energy that can be extracted. However as the oncoming wind speed increases the efficiency of the blades decreases as they approach a stall point. This paper explores the possibility of increasing the efficiency of the blades at higher wind speeds while maintaining efficiency at the lower wind speeds. The design intends to maintain efficiency at lower wind speeds by selecting the appropriate orientation and size of the airfoil cross sections based on a low oncoming wind speed and given constant rotation rate. The blades will be made more efficient at higher wind speeds by implementing a swept blade profile. Performance was investigated using the computational fluid dynamics (CFD).
Method and apparatus for acoustic plate mode liquid-solid phase transition detection (2023)

A method and apparatus for sensing a liquid-solid phase transition event is provided which comprises an acoustic plate mode detecting element placed in contact with a liquid or solid material which generates a high-frequency acoustic wave that is attenuated to an extent based on the physical state of the material is contact with the detecting element. The attenuation caused by the material in contact with the acoustic plate mode detecting element is used to determine the physical state of the material being detected. The method and device are particularly suited for detecting conditions such as the icing and deicing of wings of an aircraft. In another aspect of the present invention, a method is provided wherein the adhesion of a solid material to the detecting element can be measured using the apparatus of the invention.
Thy1 is a positive regulator of osteoblast differentiation and modulates bone homeostasis in obese mice (2018)

Thy1 (CD90), a glycosylated, glycophosphatidylinositol-anchored membrane protein highly expressed by subsets of mesenchymal stem cells and fibroblasts, inhibits adipogenesis. The role of Thy1 on bone structure and function has been poorly studied and represents a major knowledge gap. Therefore, we analyzed the long bones of wild-type (WT) and Thy1 knockout (KO) mice with micro-computed tomography (micro-CT) and histomorphometry to compare changes in bone architecture and overall bone structure. micro-CT analysis of long bones revealed Thy1 KO and WT mice fed a high-fat diet demonstrated bone structural parameters at 4 mo that differed significantly between WT and KO mice. A significant reduction in trabecular bone volume was noted in Thy1 KO mice. The most prominent differences were observed in trabecular bone volume ratio and trabecular bone connectivity density. Consistent with micro-CT measurements, histomorphometric analysis also showed decreased bone volume in the obese Thy1 KO mice compared to obese WT mice. In vitro assays revealed that osteogenic conditions increased Thy1 expression during OB differentiation and absence of Thy1 attenuated osteoblastogenesis. Together, these findings support the concept that Thy1 serves as a major mechanistic link to regulate bone formation and negatively regulate adipogenesis.-Paine, A., Woeller, C. F., Zhang, H., Garcia-Hernandez, M. L., Huertas, N., Xing, L., Phipps, R. P., Ritchlin, C. T. Thy1 is a positive regulator of osteoblast differentiation and modulates bone homeostasis in obese mice.
Cleavage of the Ewing tumour-specific EWSR1-FLI1 mRNA by hammerhead ribozymes. (2009)

The RNA corresponding to EWSR1-FLI1 is accessible for ribozyme mediated inactivation and ribozymes are able to cleave EWSR1-FLI1 specific RNA in the presence of a high background of normal cellular RNAs.
Synthesis of [18F]BODIPY: Bifunctional Reporter for Hybrid Optical/Positron Emission Tomography Imaging (2012)

Das Beste aus zwei Welten: Bodipy-basierte Bildgebungssonden können durch direkten 19F/18F-Austausch spurlos in hybride PET/Fluoreszenzbildgebungs-Reagentien überführt werden, ohne dass ein aufwändiges Neudesign notwendig ist. Dieser Ansatz hat das Potenzial, die Entwicklung von Bildgebungsreagentien zu beschleunigen, und er könnte auch die Suche nach therapeutischen Molekülen erleichtern. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
A 13-b 1.1-MHz oversampled DAC with semidigital reconstruction filtering (2004)

A digital-to-analog converter (DAC) composed of a cascaded digital /spl Sigma//spl Delta/ modulator and the combination of a semidigital/digital finite-impulse response (FIR) and an infinite-impulse response (IIR)-SC/RC filter is described. The architecture enables the analog linear reconstruction of 16/spl times/ oversampled digital signals. With the analog section implemented in CMOS 0.18-/spl mu/m and the digital part programmed into a field-programmable gate array (FPGA), the modulator plus reconstruction filter achieves a peak SNR of 78 dB. The spurious-free dynamic range reaches 80 dB and stays better than 73 dB within the 1.104-MHz signal band. A missing-tone-power ratio of 70 dB, demonstrated for a signal with 15-dB peak-to-average ratio, proves that the solution is suitable for ADSL-CO transmitters.
ChemInform Abstract: Synthesis of Optically Active Allenes Using Tandem Enzyme and Palladium‐Catalyzed Reactions. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Requirements for Abstraction and Control of TE Networks (2018)

This document provides a set of functional requirements for
abstraction and control of Traffic Engineering networks to facilitate
virtual network operation via the creation of a single virtualized
network or a seamless service. This supports operators in viewing and
controlling different domains (at any dimension: applied technology,
administrative zones, or vendor-specific technology islands) as a
single virtualized network.
Identification and differential expression of yeast SEC23‐related gene (Msec23) in mouse tissues (1993)

We have isolated a yeast SEC23-related clone (Msec23) from mouse fibroblast cDNA library. It has an open reading frame of 1721 bp (64% homologous to SEC23-2.3 kb) which can potentially encode a 64.7 kDa protein (61% homologous to 85.4 kDa product of SEC23). The deduced Msec23 protein (Msec23p) sequence contains three successive Ig-like domains at the N-terminus followed by amphipathic alpha-helical regions, suggesting the potential of Msec23p to interact with other protein components. Further, Msec23 is differentially expressed in mouse tissues with its high level in brain and fibroblasts.
Absence of Pharmacokinetic and Pharmacodynamic Interactions between Almorexant and Warfarin in Healthy Subjects (2013)

No dose adjustment of warfarin is necessary when concomitantly administered with almorexant.
Sensing coiled-coil proteins through conformational modulation of energy transfer processes – selective detection of the oncogenic transcription factor c-Jun (2011)

Designed terbium-chelating peptides were used to monitor the formation of leucine zipper associations. The sensing strategy is based on the modulation of the antenna effect from a Trp residue donor and the luminescence increase arising from the folding that takes place upon the formation of the coiled-coil structure. An application in the specific sensing of the oncogenic c-Jun transcription factor is demonstrated.
Supplementary Figure 5 from Transient Antiangiogenic Treatment Improves Delivery of Cytotoxic Compounds and Therapeutic Outcome in Lung Cancer (2023)

&lt;p&gt;PDF file - 357KB, Changes of mean voxel radioactivity of 15OH2O PET and tumor growth during intermittent PTK787 treatment.&lt;/p&gt;
Phenols from Pyrylium Salts (1981)

L b s E -Treatment of pyrylium salts 1 and Lwith dimethylsulfonium methylide yields pnenols which appear t o arise from an arene oxide.As part of e program to develop general teehniquee for the synthesis of cyclic epoxides, we envisaged that the reaction of pyrylium salts with sulfur ylides would provide ~-k e t o -~l i d ~~.1Theee w-kefo-ylides could then undergo ring closure to give arene oxides.We wish to report that pyrylium salt 1 or affords phenols 2 and 5 or 5 and 6, respectively (Scheme I).The nvcleophilic reactions of pyrylium salts have been examined in d e t a i ~, ~ including the treatment of and 9 with phosphorous ylides to provide benzene derivatives3 and the conversion of 9 into 2-(a-fury1)-acrylophenonea with phenacyl phenyl merhyl sulfanium y l i d e ~. ~ We felt this furan
Magneto-Optics and Ultrafast Optics in Micelle-Suspended Single-Walled Carbon Nanotubes (2003)

T) magneto-optical study and 2) a femtosecond nearinfrared pump-probe study of micelle-suspended singlewalled carbon nanotubes (SWCNTs) whose linear absorption and emission spectra show a number of chiralitydependent peaks. In 1), we observed significant peak broadening and splitting in some of the absorption peaks in magnetic fields above 30 T, which we interpret as an onset of the Aharonov-Bohm-type oscillations of band gaps predicted for SWCNTs in high magnetic fields applied along the tube axis. In 2), we identified two distinct regimes in ultrafast carrier relaxation in SWCNTs: fast (0.3-1.2 ps) and slow (5-20 ps). The slow component, which has not been observed previously, is resonantly enhanced whenever the pump photon energy resonates with an interband absorption peak, and we attribute it to radiative carrier recombination. The slow component is also dependent on the pH of the solution, which suggests an important role played by H + ions surrounding the nanotubes (as “acceptors”). 1
Endometrial Integrins (1995)

The assessment of endometrial function has lagged far behind other clinical examples in the field of endocrinology. Nevertheless, the importance of the endometrium to the establishment normal pregnancy and the associated biochemical complexities in this tissue makes its study of paramount importance. Integrins are a relatively new family of cell adhesion molecules that appear to undergo fascinating temporal and spatial changes in the endometrium throughout the menstrual cycle and into pregnancy suggesting a direct involvement in the process of embryonic implantation. Two integrins, α4β1 and αvβ3, are coex-pressed on endometrial epithelial cells only during the putative window of implantation, and the aberrant expression of the latter appears to predict infertility. Aberrant expression of the avβ3 integrin is found in women with hormonal inadequacy (luteal phase deficiency) and in women with certain inflammatory states (endometriosis, endometritis, and hydrosalpinges). With no currently accepted methods for the assessment of endometrial receptivity, integrins offer a rational means to investigate such defects in the infertile woman. Further, lessons learned from infertile women may lead the way toward improved diagnosis in “unexplained infertility” and safer and more efficacious means of contraception in the future
Sex-specificity of the C. elegans metabolome (2022)

Abstract Recent studies of animal metabolism have revealed large numbers of novel metabolites that are involved in all aspects of organismal biology, but it is unclear to what extent metabolomes differ between sexes. Here, using untargeted comparative metabolomics for the analysis of wildtype animals and a series of germline mutants, we show that C. elegans hermaphrodites and males exhibit pervasive metabolomic differences. Several hundred small molecules are produced exclusively or in much larger amounts in one sex, including a host of previously unreported metabolites that incorporate building blocks from nucleoside, carbohydrate, lipid, and amino acid metabolism. A subset of male-enriched metabolites is specifically associated with the presence of a male germline, whereas enrichment of other compounds requires a male soma. Further, we show that one of the male germline-dependent metabolites, an unusual dipeptide incorporating N , N -dimethyltryptophan, accelerates the last stage of larval development in hermaphrodites. Our results serve as a foundation for mechanistic studies of how the genetic sex of soma and germline shape the C. elegans metabolome and provides a blueprint for the discovery of sex-dependent metabolites in other animals.
Quality of Experience-Centric Management of Adaptive Video Streaming Services (2018)

Video streaming applications currently dominate Internet traffic. Particularly, HTTP Adaptive Streaming (HAS) has emerged as the dominant standard for streaming videos over the best-effort Internet, thanks to its capability of matching the video quality to the available network resources. In HAS, the video client is equipped with a heuristic that dynamically decides the most suitable quality to stream the content, based on information such as the perceived network bandwidth or the video player buffer status. The goal of this heuristic is to optimize the quality as perceived by the user, the so-called Quality of Experience (QoE). Despite the many advantages brought by the adaptive streaming principle, optimizing users’ QoE is far from trivial. Current heuristics are still suboptimal when sudden bandwidth drops occur, especially in wireless environments, thus leading to freezes in the video playout, the main factor influencing users’ QoE. This issue is aggravated in case of live events, where the player buffer has to be kept as small as possible in order to reduce the playout delay between the user and the live signal. In light of the above, in recent years, several works have been proposed with the aim of extending the classical purely client-based structure of adaptive video streaming, in order to fully optimize users’ QoE. In this article, a survey is presented of research works on this topic together with a classification based on where the optimization takes place. This classification goes beyond client-based heuristics to investigate the usage of server- and network-assisted architectures and of new application and transport layer protocols. In addition, we outline the major challenges currently arising in the field of multimedia delivery, which are going to be of extreme relevance in future years.
Efficient propagation of TM polarized light in photonic crystal components exhibiting band gaps for TE polarized light (2003)

We have investigated the properties of TM polarized light in planar photonic crystal waveguide structures, which exhibit photonic band gaps for TE polarized light. Straight and bent photonic crystal waveguides and couplers have been fabricated in silicon-on-insulator material and modelled using a 3D finite-difference-time-domain method. The simulated spectra are in excellent agreement with the experimental results, which show a propagation loss as low as 2.5+/-4 dB/mm around 1525 nm and bend losses at 2.9+/-0.2 dB for TM polarized light. We demonstrate a high coupling for TM polarized light in a simple photonic crystal coupler with a size of ~ 20 m x 20 m. These promising features may open for the realization of ultra-compact photonic crystal components, which are easily integrated in optical communication networks.
Robust Burn Control of Fusion Reactors with Modulation of Refueling Rate (1994)

An integrated 0-dimensional plasma-control code, ASH, has been developed and employed to study the possibility of controlling the burn condition of an ITER-type fusion reactor by modulating the refueling rate. A key feature of this study is the incorporation of robust control theory to allow for modeling uncertainties. A constant gain proportional feedback controller is synthesized; the values of feedback gains are obtained by the H∞ algorithm. With this control method, modulation of the refueling rate alone can potentially stabilize fusion burn with the alpha confinement time τ*α = 11τE, or controller delay τdelay = 1.5τE, or D-T recycling ratio 98%. These limitations are fairly restrictive, indicating that added control, e.g., via input power modulation, may be necessary.
Molecular alterations associated with chronic exposure to cigarette smoke and chewing tobacco in normal oral keratinocytes (2018)

Tobacco usage is a known risk factor associated with development of oral cancer. It is mainly consumed in two different forms (smoking and chewing) that vary in their composition and methods of intake. Despite being the leading cause of oral cancer, molecular alterations induced by tobacco are poorly understood. We therefore sought to investigate the adverse effects of cigarette smoke/chewing tobacco exposure in oral keratinocytes (OKF6/TERT1). OKF6/TERT1 cells acquired oncogenic phenotype after treating with cigarette smoke/chewing tobacco for a period of 8 months. We employed whole exome sequencing (WES) and quantitative proteomics to investigate the molecular alterations in oral keratinocytes chronically exposed to smoke/ chewing tobacco. Exome sequencing revealed distinct mutational spectrum and copy number alterations in smoke/ chewing tobacco treated cells. We also observed differences in proteomic alterations. Proteins downstream of MAPK1 and EGFR were dysregulated in smoke and chewing tobacco exposed cells, respectively. This study can serve as a reference for fundamental damages on oral cells as a consequence of exposure to different forms of tobacco.
L'urgent besoin d'une régulation sanitaire fondée sur les preuves (2010)

Les exigences reglementaires jouent un role cle dans la regulation de nombreuses activites humaines au sein desquelles les preoccupations concernant la securite sanitaire occupent une place majeure. Cet article d'opinion analyse certains des enjeux souleves par l'augmentation continuelle des exigences des autorites de sante concernant les medicaments et les vaccins a usage humain, avec des consequences differentes sur les pays developpes et les pays en voie de developpement. Les couts et les benefices des exigences reglementaires ne sont que tres peu evalues et ne font pas l'objet d'etudes scientifiques suffisantes. Il en resulte probablement un gaspillage significatif de fonds publics comme prives. Beaucoup de questions se posent a propos de l'evaluation du rapport benefice/risque, qui n'est pas toujours adaptee au contexte et souvent inadequate. De la meme facon que la medecine a evolue depuis 30 ans vers une medecine fondee sur les preuves (evidence based medicine), nous proposons d'inciter a la mise en place d'une reglementation (evidence based regulation) fondee sur les preuves. Cela d'autant plus urgent que l'impact financier des exigences reglementaires ne va faire que croitre, avec des consequences particulierement graves sur la capacite d'innovation, surtout sur les pays en voie de developpement dont les besoins sont enormes et les ressources tres limitees.
Reduction of optical bleaching in phosphorus doped Ge layer on Si (2017)

Optical bleaching is studied on undoped and highly doped Ge layer on Si using Transient Absorption Spectroscopy. Upon optical pumping, doped Ge showed a reduction in optical bleaching as compared to undoped Ge due to the homogeneous broadening effect in doped Ge.
Selective photoaggregation of metal atoms to small bimetallic clusters of known size. The chromium-molybdenum system CrnMom (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSelective photoaggregation of metal atoms to small bimetallic clusters of known size. The chromium-molybdenum system CrnMomWerner E. Klotzbuecher and Geoffrey A. OzinCite this: J. Am. Chem. Soc. 1978, 100, 7, 2262–2264Publication Date (Print):March 1, 1978Publication History Published online1 May 2002Published inissue 1 March 1978https://pubs.acs.org/doi/10.1021/ja00475a064https://doi.org/10.1021/ja00475a064research-articleACS PublicationsRequest reuse permissionsArticle Views75Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Solvent-Processed Metallic Lithium Microparticles for Lithium Metal Batteries (2019)

Foils that serve as Li metal anodes suffer from poor cycling and safety concerns due to dramatic volume changes and dendrites formation. In this work, we report a convenient solvent-processed approach to prepare and extract high-purity lithium metal microparticles (Li MPs). As a proof-of-concept, a freestanding porous Li MPs/carbon nanotubes composite anode (LMCA) based on mechanically bound interconnected Li MPs was prepared and showed an improved cycling performance compared to a Li foil anode, as the created 3D porous structures can alleviate electrode volume changes and increase electroactive surface areas.