gebhart/patrepeval huggingface dataset:
North-Bound Distribution of Link-State and Traffic Engineering (TE) Information Using BGP (2016)

In a number of environments, a component external to a network is
called upon to perform computations based on the network topology and
current state of the connections within the network, including Traffic
Engineering (TE) information. This is information typically
distributed by IGP routing protocols within the network. This
document describes a mechanism by which link-state and TE information
can be collected from networks and shared with external components
using the BGP routing protocol. This is achieved using a new BGP
Network Layer Reachability Information (NLRI) encoding format. The
mechanism is applicable to physical and virtual IGP links. The
mechanism described is subject to policy control. Applications of
this technique include Application-Layer Traffic Optimization (ALTO)
servers and Path Computation Elements (PCEs).
An efficient LISP-execution architecture with a new representation for list structures (1985)

article Free Access Share on An efficient LISP-execution architecture with a new representation for list structures Authors: Gurindar S. Sohi Coordinated Science Laboratory, University of Illinois, 1101 W. Springfield, Urbana, IL Coordinated Science Laboratory, University of Illinois, 1101 W. Springfield, Urbana, ILView Profile , Edward S. Davidson Coordinated Science Laboratory, University of Illinois, 1101 W. Springfield, Urbana, IL Coordinated Science Laboratory, University of Illinois, 1101 W. Springfield, Urbana, ILView Profile , Janak H. Patel Coordinated Science Laboratory, University of Illinois, 1101 W. Springfield, Urbana, IL Coordinated Science Laboratory, University of Illinois, 1101 W. Springfield, Urbana, ILView Profile Authors Info & Claims ACM SIGARCH Computer Architecture NewsVolume 13Issue 3June 1985 pp 91–98https://doi.org/10.1145/327070.327136Published:01 June 1985Publication History 7citation319DownloadsMetricsTotal Citations7Total Downloads319Last 12 Months17Last 6 weeks3 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Altered Na+Channels Promote Pause-Induced Spontaneous Diastolic Activity in Long QT Syndrome Type 3 Myocytes (2006)

Long QT syndrome (LQTS) type 3 (LQT3), typified by the DeltaKPQ mutation (LQT3 mutation in which amino acid residues 1505 to 1507 [KPQ] are deleted), is caused by increased sodium entry during the action potential plateau resulting from mutation-altered inactivation of the Na(v)1.5 channel. Although rare, LQT3 is the most lethal of common LQTS variants. Here we tested the hypothesis that cellular electrical dysfunction, caused not only by action potential prolongation but also by mutation-altered Na(+) entry, distinguishes LQT3 from other LQTS variants and may contribute to its distinct lethality. We compared cellular electrical activity in myocytes isolated from mice heterozygous for the DeltaKPQ mutation (DeltaKPQ) and myocytes from wild-type littermates. Current-clamp pause protocols induced rate-dependent spontaneous diastolic activity (delayed after depolarizations) in 6 of 7 DeltaKPQ, but no wild-type, myocytes (n=11) tested. Voltage-clamp pause protocols that independently control depolarization duration and interpulse interval identified a distinct contribution of both depolarization duration and mutant Na(+) channel activity to the generation of Ca(i)(2+)-dependent diastolic transient inward current. This was found at rates and depolarization durations relevant both to the mouse model and to LQT3 patients. Flecainide, which preferentially inhibits mutation-altered late Na(+) current and is used to treat LQT3 patients, suppresses transient inward current formation in voltage-clamped DeltaKPQ myocytes. Our results demonstrate a marked contribution of mutation-altered Na(+) entry to the incidence of pause-dependent spontaneous diastolic activity in DeltaKPQ myocytes and suggest that altered Na(+) entry may contribute to the elevated lethality of LQT3 versus other LQTS variants.
Urinary and Plasma Catecholamines and Metanephrines in Dogs with Pheochromocytoma, Hypercortisolism, Nonadrenal Disease and in Healthy Dogs (2015)

Measurement of normetanephrine is the preferred biochemical test for PC and urine was superior to plasma.
A Multidrug-Resistant MCF-7 Human Breast Cancer Cell Line Which Exhibits Cross-Resistance to Antiestrogens and Hormone-Independent Tumor Growthin Vivo (1988)

MCF-7 human breast cancer cells provide a useful in vitro model system to study hormone-responsive breast cancer as they contain receptors for estrogen and progesterone, and estrogen both induces the synthesis of specific proteins in these cells and increases their rate of proliferation. An MCF-7 cell line which was selected for resistance to adriamycin (MCF-7/AdrR) exhibits the phenotype of multidrug resistance (MDR), and displays multiple biochemical changes. MDR in MCF-7/AdrR is also associated with a loss of mitogenic response to estrogen and the development of cross-resistance to the antiestrogen 4-hydroxytamoxifen. In addition, while the parental MCF-7 cell line responds to estrogen with increased levels of progesterone receptors and the secretion of specific proteins, these estrogen responses are lost in MCF-7/AdrR. Furthermore, while the formation of tumors in nude mice by wild-type MCF-7 cells is dependent upon the presence of estrogen, MCF-7/AdrR cells form tumors in the absence of exogenous estrogen administration. These changes in hormonal sensitivity and estrogen-independent tumorigenicity of the multidrug-resistant MCF-7 cell line are associated with a loss of the estrogen receptor and a concomitant increase in the level of receptors for epidermal growth factor. Thus, in MCF-7/AdrR cells, the development of MDR is associated with alterations in the expression of both cytosolic and membrane receptors, resulting in resistance to hormonal agents and the expression of hormone-independent tumor formation.
Equal area property of narrow resonances induced in coupled Doppler-broadened systems by intense laser radiation (1975)

It is well known that the spectral line shape of the narrow change signal induced at one Doppler-broadened transition by an intense laser field resonating with a second one can be extremely complex and nonclassical in form, the exact details depending on such factors as the direction of observation relative to the propagation direction of the laser field and its spatial form (traveling wave or standing wave). Nevertheless, the area under the change signal line shape, i.e. its frequency-integrated intensity, is always the same for a given laser field, and is independent of the coupling between laser and change-signal fields. A proof of this equal area property, based on quantum-mechanical transition-rate theory, is given for a three-level system composed of degenerate or near-degenerate states. The resulting expression is also applicable to line-shape calculations for experiments which study resonance fluorescence induced by intense laser or resonance radiation or other forms of excitation.
Effective index modelling of photonic crystal surface-emitting lasers (Conference Presentation) (2018)

Photonic crystal surface emitting lasers (PCSEL) are of interest in order to achieve large area single mode operation, excellent beam quality, and high output powers. Coherent PCSEL arrays have also been realised and lasing mode control of PCSELs has been demonstrated by using external in-plane feedback. However, the design and analysis of PCSELs has been limited by current modelling techniques. The plane wave expansion method is only applicable to infinite structures whilst the finite difference time domain method is computationally intensive especially when modelling large area, three dimensional finite devices. Other analytical approach, such as coupled mode analysis, leads to significant mathematical complication. None of these are well suited to accurately describing complex PCSEL devices, nor the effect of in-plane feedback. We introduce a general quasi-analytical model based on the separation of variables and a quasi-scalar field distribution. The multilayer planar structure in the growth direction is accounted for by computing the effective indices corresponding to the in-plane bound guided modes. This operation results in a sculpted, periodic index distribution. Next, by first assuming index uniformity along the z-axis, a piecewise constant multilayer periodic media results. An effective wave impedance of the waves supported in this structure are then computed and used to construct the 3D device. In this way, the final device characteristics account for the 2D periodic photonic crystal media. We compare our modelling to other methods, and various experimental reports. In particular we focus upon the effect of external in-plane feedback on PCSELs.
Color Appearance Models (2013)

The chromatic adaptation transforms go a long way toward extending tristimulus colorimetry toward the prediction of color appearance. A chromatic adaptation transform alone cannot be used to describe the actual color appearance of stimuli. To do this, one must use the appearance parameters, the absolute color appearance attributes of brightness, colorfulness, and hue and the relative color appearance attributes of lightness, chroma, saturation, and, again, hue. These terms are used to describe the color appearance of stimuli. Some fairly simple uniform color spaces, such as the CIE 1976 L*a*b* color space (CIELAB) and the CIE 1976 L*u*v* color space (CIELUV), can be considered color appearance models. These color spaces include simple chromatic adaptation transforms and predictors of lightness, chroma, and hue. This chapter presents the general construction of a color appearance model, and a discussion of CIELAB as a specific example. Controlled Vocabulary Terms colorimetry
Role of cell surface carbohydrates and proteins in cell behavior: studies on the biochemical reversion of an N-acetylglucosamine-deficient fibroblast mutant. (1977)

AD6, a mutant derived from 3T3 Balb/c cells, is characterized by low adhesion to substratum, round shape, increase in surface microvilli, increase in agglutinability by concanavalin A, and loss of directional motility. These properties are often observed in transformed cells. However, the mutant has normal growth properties and anchorage-dependence of growth, and it does not form tumors. In AD6, the biosynthesis of complex carbohydrates and glycoproteins is impaired because of a block in the acetylation of GlcN-6-P. This defect is responsible for all the surface alterations because feeding of GlcNAc to AD6 cells corrects the defects in the synthesis of complex carbohydrates and the exposure of glycoproteins at the outer surface of the plasma membrane. Parallel to this biochemical reversion, there is full restoration of the altered biological properties. In contrast, GlcNAc has no effect on the morphologic features of two lines of transformed cells. Our results suggest that the carbohydrate portion of cell surface proteins has an important role in adhesion and related aspects of cell behavior. The fact that a defined alteration of the cell surface induces many properties often encountered in transformed cells, without affecting control of cell division, strongly suggests that these alterations in properties are not sufficient to account for the loss of growth regulation.
Catalyst Combustors with B-Doped SiGe/Au Thermopile for Micro-Power-Generation (2006)

A micromachined thermoelectric (TE) power generator with a ceramic catalyst combustor operating at room temperature (RT) has been developed. A thermopile of 20 thin-film couples of B-doped Si0.8Ge0.2/Au and a Pt-loaded alumina ceramic thick-film catalyst combustor were integrated on a thin dielectric membrane, which was fabricated by bulk-Si wet etching. We have demonstrated a successful power generation of 0.26 µW using the micro-TE-generator with a fuel gas flow of 3 vol. % H2 in air, 1000 ccm, at RT.
Spiral optical designs for nonimaging applications (2011)

Manufacturing technologies as injection molding or embossing specify their production limits for minimum radii of the vertices or draft angle for demolding, for instance. In some demanding nonimaging applications, these restrictions may limit the system optical efficiency or affect the generation of undesired artifacts on the illumination pattern. A novel manufacturing concept is presented here, in which the optical surfaces are not obtained from the usual revolution symmetry with respect to a central axis (z axis), but they are calculated as free-form surfaces describing a spiral trajectory around z axis. The main advantage of this new concept lies in the manufacturing process: a molded piece can be easily separated from its mold just by applying a combination of rotational movement around axis z and linear movement along axis z, even for negative draft angles. Some of these spiral symmetry examples will be shown here, as well as their simulated results.
Visualizing internal 3D structures with submicrometer resolution (2007)

High-resolution Computed Tomography widely expands the spectrum of detectable internal microstructures. The new nanotom is the first 180 kV nanoCT s ystem worldwide which is tailored completely to highest-resolution applications in material scienc e, micro mechanics, electronics, geology etc. The CT results demonstrate the possibility to analyse the 3D-m icrostructure of material samples with minimal preparation and the exceptional resolution of less than 0.5 mic rons per voxel.
Supplementary Figure 4 from RKI-1447 Is a Potent Inhibitor of the Rho-Associated ROCK Kinases with Anti-Invasive and Antitumor Activities in Breast Cancer (2023)

&lt;p&gt;PDF file, 131K, Molecular mode of action of RKI-1447. Interaction of the ATP site of Rock1 kinase in complex with RKI-1447 determined by X-ray crystallography at 2.9 � resolution. The hinge region is indicated in orange, the DFG motif in cyan, and RKI-1447 in yellow. Displayed in red is the Fo-Fc electron density map contoured at 2.5σ around the RKI-1447 inhibitor which was omitted during refinement. Potential hydrogen bonding and van der Waal interactions are shown as black and green dotted lines, respectively.&lt;/p&gt;
Supplementary Figure S3 from EPHA2 Is a Mediator of Vemurafenib Resistance and a Novel Therapeutic Target in Melanoma (2023)

&lt;p&gt;Supplementary Figure S3. Fig. S3. Validation of EphA2 as the target of EphA2 inhibitors.&lt;/p&gt;
Wavelength Selective 3D Topology Optimized Photonic Crystal Devices (2013)

A compact photonic crystal drop filter has been designed using 3D topology optimization and fabricated in silicon-on-insulator material. Measurements and modeling are in excellent agreement showing a low-loss ~11nm 3dB bandwidth of the filter.
Inhibition of IgE-mediated mast cell activation by the paired Ig-like receptor PIR-B (2001)

The potential of the paired Ig-like receptors of activating (PIR-A) and inhibitory (PIR-B) types for modifying an IgE antibody-mediated allergic response was evaluated in mouse bone marrow-derived mast cells. Although mast cells produced both PIR-A and PIR-B, PIR-B was found to be preferentially expressed on the cell surface, where it was constitutively tyrosine phosphorylated and associated with intracellular SHP-1 protein tyrosine phosphatase. PIR-B coligation with the IgE receptor (FcRI) inhibited IgE-mediated mast cell activation and release of serotonin. Surprisingly, the inhibitory activity of PIR-B was unimpaired in SHP-1-deficient mast cells. A third functional tyrosine-based inhibitory motif, one that fails to bind the SHP-1, SHP-2, and SHIP phosphatases, was identified in parallel studies of FcRI-bearing rat basophilic leukemia (RBL) cells transfected with constructs having mutations in the PIR-B cytoplasmic region. These results define the preferential expression of the PIR-B molecules on mast cells and an inhibitory potential that can be mediated via a SHP-1-independent pathway.
A numerical calculation of the hydraulic permeability of three-dimensional disordered fibrous media (1997)

Hydraulic permeabilities of polymeric membranes and gels are of interest both for calculating fluid flow rates and hindered diffusion coefficients. We have calculated hydraulic permeabilities for monomodal and bimodal, periodic and random fibrous media. Hydrodynamic interactions between fibers are calculated by applying a numerical version of slender body theory to a collection of fibers in a cubic cell many Brinkman screening lengths in dimension. Results for random media are obtained by averaging over many ensembles of fibers. To account for the surrounding medium, the line distribution of point forces along the fiber axes are replicated throughout space by using the Ewald summation technique. Results for periodic media agree with previous theoretical results up to a fiber volume fraction of 50% for parallel flow and 40% for transverse flow. Hydraulic permeabilities calculated for three-dimensional, disordered media with monomodal and bimodal distributions of fiber radius are compared with existing theories and with experimentally determined hydraulic permeabilities for a range of fiber volume fractions. Specific calculations are performed for agarose and collagen/proteoglycan gel systems, which are well described as bimodal fibrous media and are relevant to bioseparations and physiological systems, respectively.
Fail-Safe Human Detection for Drones Using a Multi-Modal Curriculum\n Learning Approach (2021)

Drones are currently being explored for safety-critical applications where\nhuman agents are expected to evolve in their vicinity. In such applications,\nrobust people avoidance must be provided by fusing a number of sensing\nmodalities in order to avoid collisions. Currently however, people detection\nsystems used on drones are solely based on standard cameras besides an emerging\nnumber of works discussing the fusion of imaging and event-based cameras. On\nthe other hand, radar-based systems provide up-most robustness towards\nenvironmental conditions but do not provide complete information on their own\nand have mainly been investigated in automotive contexts, not for drones. In\norder to enable the fusion of radars with both event-based and standard\ncameras, we present KUL-UAVSAFE, a first-of-its-kind dataset for the study of\nsafety-critical people detection by drones. In addition, we propose a baseline\nCNN architecture with cross-fusion highways and introduce a curriculum learning\nstrategy for multi-modal data termed SAUL, which greatly enhances the\nrobustness of the system towards hard RGB failures and provides a significant\ngain of 15% in peak F1 score compared to the use of BlackIn, previously\nproposed for cross-fusion networks. We demonstrate the real-time performance\nand feasibility of the approach by implementing the system in an edge-computing\nunit. We release our dataset and additional material in the project home page.\n
Thermodilatometry of Laminated Glass (2011)

In this report, we describe the application of standard thermodilatometry (TD) as a tool to evaluate the thermal behavior of laminated glass assemblies where two glass layers are bonded together by a polymer interlayer. The measurement of the displacement perpendicular to the plane of the glass multilayer enables to follow the thermal expansion up to the point where interfacial debonding, thermal degradation, or another thermal event takes place. The effect of heating rate has been investigated and a procedure is eventually proposed to estimate the onset temperature at interfacial failure from the TD data. It is also shown that TD measurements of the interlayer along the side of the glass laminate give a sharp signal at interfacial failure. Finally, following the sandwich seal model where it is assumed that, during heating, the constrained interlayer is in compression due to the mismatch in thermal expansivity between the outer glass and the inner polymer layer, we establish the stress–strain behavior of the interlayer up to the debonding temperature. Viscoelastic and structural relaxation of the interlayer are taken into account empirically from modulus and thermal expansion data collected along similar thermal paths.
Glyburide, a KATP Channel Antagonist, Attenuates the Cardioprotective Effects of Isoflurane in Stunned Myocardium (1996)

This investigation examined the role of myocardial adenosine triphosphate-regulated potassium (KATP) channels in isoflurane-induced enhancement of myocardial function after reversible tissue injury produced by a 15-min left anterior descending coronary artery occlusion (LAD) and reperfusion. Dogs (n = 14) were chronically instrumented for measurement of left ventricular (LV) and aortic blood pressure, cardiac output, coronary blood flow velocity, and subendocardial segment length. Regional myocardial contractility was evaluated with preload recruitable work area (PRWA). Isovolumic relaxation was assessed with a time constant (tau). Hemodynamic variables and LV function were measured in the conscious state, during 2% isoflurane anesthesia for 45 min before and during a 15-min LAD occlusion, and at several intervals after reperfusion in dogs pretreated with glyburide (0.3 mg/kg, intravenously) or drug vehicle. LAD occlusion caused regional dyskinesia and increases in tau. Vehicle-pretreated dogs demonstrated full recovery of segment shortening by 5 h postreperfusion and recovery of PRWA and tau by 30 min postreperfusion. In contrast, dogs pretreated with glyburide demonstrated sustained systolic and diastolic dysfunction. Segment shortening recovered to only 70% +/- 5%, PRWA remained depressed at 48% +/- 10% and tau was prolonged to 116% +/- 5% of control values at 5 h postreperfusion. The results indicate that isoflurane enhances recovery of myocardial contractile function by 5 h postreperfusion, in comparison to previous findings in conscious dogs. These effects are partially blocked by glyburide pretreatment, indicating that KATP channel activation by isoflurance may mediate these cardioprotective effects.
Evaluating Transition-Metal-Catalyzed Transformations for the Synthesis of Laulimalide (2009)

Laulimalide is a structurally unique 20-membered marine macrolide displaying microtubule stabilizing activity similar to that of paclitaxel and the epothilones. The use of atom-economical transformations such as a Rh-catalyzed cycloisomerization to form the endocyclic dihydropyran, a dinuclear Zn-catalyzed asymmetric glycolate aldol reaction to prepare the syn 1,2-diol, and an intramolecular Ru-catalyzed alkene-alkyne coupling to build the macrocycle enabled us to synthesize laulimalide via an efficient and convergent pathway. The designed synthetic route also allowed us to prepare an analogue of the natural product that possesses significant cytotoxic activity.
Exciton Energy Transfer in Pairs of Single-Walled Carbon Nanotubes (2008)

We studied the exciton energy transfer in pairs of semiconducting nanotubes using high-resolution optical microscopy and spectroscopy on the nanoscale. Photoluminescence from large band gap nanotubes within bundles is observed with spatially varying intensities due to distance-dependent internanotube transfer. The range of efficient energy transfer is found to be limited to a few nanometers because of competing fast nonradiative relaxation responsible for low photoluminescence quantum yield.