gebhart/patrepeval huggingface dataset:
Theoretical Investigations of NiYSZ in the Presence of H[sub 2]S (2006)

Quantum chemistry and molecular dynamics were used to evaluate the performance of solid oxide fuel cell anode materials in the presence of and . The most common anode material Ni-yttria-stabilized zirconia (Ni-YSZ) was used for the study. It was found that the presence of has an important effect on the oxidation of . Thermodynamics and transport limitations favor the oxidation of instead of . Furthermore it is predicted that the presence of slows down the oxidation of the hydrogen due to transport limitations (the molecules tend to be surrounded by molecules in the media).
Toward Operator-to-Waveform 5G Radio Access Network Slicing (2020)

RAN slicing refers to a vision where multiple MNOs are assigned virtual networks (i.e., slices) instantiated on top of the same physical network resources. Existing work in this area has addressed RAN slicing at different levels of network abstraction, but has often neglected the multitude of tightly intertwined inter-level operations involved in practical slicing systems. For this reason, this article discusses a novel framework for operator-to-waveform 5G RAN slicing. In the proposed framework, slicing operations are treated holistically, including MNOs' selection of base stations and maximum number of users, down to the waveform-level scheduling of resource blocks. Simulation results show that the proposed framework generates RAN slices where 95 percent of allocated resources can be used to perform coordination- based 5G transmission technologies, and facilitates the coexistence of multiple RAN slices providing up to 120 percent improvement in terms of SINR experienced by mobile users.
MicroRNAs Involved in Metastasis of Hepatocellular Carcinoma: Target Candidates, Functionality and Efficacy in Animal Models and Prognostic Relevance (2019)

Hepatocellular carcinoma (HCC) is responsible for the second-leading cancer-related death toll worldwide. Although sorafenib and levantinib as frontline therapy and regorafenib, cabazantinib and ramicurimab have now been approved for second-line therapy, the therapeutic benefit is in the range of only a few months with respect to prolongation of survival. Aggressiveness of HCC is mediated by metastasis. Intrahepatic metastases and distant metastasis to the lungs, lymph nodes, bones, omentum, adrenal gland and brain have been observed. Therefore, the identification of metastasis-related new targets and treatment modalities is of paramount importance. In this review, we focus on metastasis-related microRNAs (miRs) as therapeutic targets for HCC. We describe miRs which mediate or repress HCC metastasis in mouse xenograft models. We discuss 18 metastasis-promoting miRs and 35 metastasis-inhibiting miRs according to the criteria as outlined. Six of the metastasis-promoting miRs (miR-29a, -219-5p, -331-3p, 425-5p, -487a and -1247-3p) are associated with unfavourable clinical prognosis. Another set of six down-regulated miRs (miR-101, -129-3p, -137, -149, -503, and -630) correlate with a worse clinical prognosis. We discuss the corresponding metastasis-related targets as well as their potential as therapeutic modalities for treatment of HCC-related metastasis. A subset of up-regulated miRs -29a, -219-5p and -425-5p and down-regulated miRs -129-3p and -630 were evaluated in orthotopic metastasis-related models which are suitable to mimic HCC-related metastasis. Those miRNAs may represent prioritized targets emerging from our survey.
Optical MEMS notch filter based on the multi-mode interference in a butterfly metallic waveguide (2018)

In this work, we report a novel notch optical filter based on the imaging properties of a MEMS-based Multimode Interference (MMI) waveguide. The concept is based on the dependence of the imaging lengths on the different wavelengths, where each wavelength exits the waveguide at a different lateral position. Thus, by properly choosing the output waveguide position, it is possible to have a good selective optical filter as well as a good notch optical filter (the complementary response). To validate this concept an MMI structure is fabricated using Deep Reactive Ion Etching (DRIE) technology on a silicon-on-insulator (SOI) wafer. The walls of the waveguide are metalized with Aluminum to decrease the insertion loss. The design makes use of the compactness of the parabolic butterfly shape to reduce the MMI length. The structure is fed by a 9/125 single-mode fiber and the Amplified Spontaneous Emission ASE out of a Semiconductor Optical Amplifier is used as a wideband source for the optical response characterization. The output is measured on an optical spectrum analyzer demonstrating a notch filter response around 1550 nm with about 20-dB rejection ratio. The reported results open the door for integrated, low-cost and fabrication insensitive optical MEMS notch filter.
Neurosurgical Operative Atlas (2018)

This work contains up-to-date presentations by contributors from several medical specialties on the incidence, clinical manifestations and neuropathology of subarachnoid haemorrhage (SAH). The various mechanisms of brain injury caused by SAH, and detailed management strategies are also covered. Finally, future directions are discussed.
Redfish Facilities Equipment Management Overview (2017)

In addition to managing IT equipment, the Redfish standard management API data models are being extended to describe data center facility power, cooling and environmental control equipment. This presentation describes the scope of equipment, data models and industry participation for standardized Data Center Information Management (DCIM) management API and data definitions.
RANTES and macrophage inflammatory protein 1 alpha induce the migration and activation of normal human eosinophil granulocytes. (1992)

The cellular infiltrates of certain inflammatory processes found in parasitic infection or in allergic diseases consist predominantly of eosinophilic granulocytes, often in association with activated T cells. This suggests the existence of chemotactic agonists specific for eosinophils and lymphocyte subsets devoid of neutrophil-activating properties. We therefore examined four members of the intercrine/chemokine superfamily of cytokines (monocyte chemotactic peptide 1 [MCP-1], RANTES, macrophage inflammatory protein 1 alpha [MIP-1 alpha], and MIP-1 beta), which do not activate neutrophils, for their ability to affect different eosinophil effector functions. RANTES strongly attracted normal human eosinophils by a chemotactic rather than a chemokinetic mechanism with a similar efficacy as the most potent chemotactic myeloid cell agonist, C5a. MIP-1 alpha also induced eosinophil migration, however, with lower efficacy. RANTES and MIP-1 alpha induced eosinophil cationic protein release in cytochalasin B-treated eosinophils, but did not promote leukotriene C4 formation by eosinophils, even after preincubation with interleukin 3 (IL-3), in contrast to other chemotactic agonists such as C5a and formyl-methionyl-leucyl-phenylalanine (FMLP). RANTES, but not MIP-1 alpha, induced a biphasic chemiluminescence response, however, of lower magnitude than C5a. RANTES and MIP-1 alpha both promoted identical transient changes in intracellular free calcium concentration ([Ca2+]i), with kinetics similar to those induced by chemotactic peptides known to interact with G protein-coupled receptors. No cross-desensitization towards other peptide agonists (e.g., C5a, IL-8, FMLP) was observed, suggesting the presence of specific receptors. Despite its weaker eosinophil-activating properties, MIP-1 alpha was at least 10 times more potent on a molar basis than RANTES at inducing [Ca2+]i changes. Interestingly, RANTES deactivated the MIP-1 alpha-induced [Ca2+]i changes, while the RANTES response was preserved after MIP-1 alpha stimulation. MCP-1, a potent monocyte chemoattractant and basophil agonist, as well as MIP-1 beta, a peptide with pronounced homology to MIP-1 alpha, did not activate the eosinophil functions tested. Our results indicate that RANTES and MIP-1 alpha are crucial mediators of inflammatory processes in which eosinophils predominate.
Benchmark assessment of molecular geometries and energies from small molecule force fields (2020)

<b>Background:</b> Force fields are used in a wide variety of contexts for classical molecular simulation, including studies on protein-ligand binding, membrane permeation, and thermophysical property prediction. The quality of these studies relies on the quality of the force fields used to represent the systems. <b>Methods:</b> Focusing on small molecules of fewer than 50 heavy atoms, our aim in this work is to compare nine force fields: GAFF, GAFF2, MMFF94, MMFF94S, OPLS3e, SMIRNOFF99Frosst, and the Open Force Field Parsley, versions 1.0, 1.1, and 1.2. On a dataset comprising 22,675 molecular structures of 3,271 molecules, we analyzed force field-optimized geometries and conformer energies compared to reference quantum mechanical (QM) data. <b>Results:</b> We show that while OPLS3e performs best, the latest Open Force Field Parsley release is approaching a comparable level of accuracy in reproducing QM geometries and energetics for this set of molecules. Meanwhile, the performance of established force fields such as MMFF94S and GAFF2 is generally somewhat worse. We also find that the series of recent Open Force Field versions provide significant increases in accuracy. <b>Conclusions:</b> This study provides an extensive test of the performance of different molecular mechanics force fields on a diverse molecule set, and highlights two (OPLS3e and OpenFF 1.2) that perform better than the others tested on the present comparison. Our molecule set and results are available for other researchers to use in testing.
Differential Role of β1Cand β1AIntegrin Cytoplasmic Variants in Modulating Focal Adhesion Kinase, Protein Kinase B/AKT, and Ras/Mitogen-activated Protein Kinase Pathways (2000)

The integrin cytoplasmic domain modulates cell proliferation, adhesion, migration, and intracellular signaling. The beta(1) integrin subunits, beta(1C) and beta(1A), that contain variant cytoplasmic domains differentially affect cell proliferation; beta(1C) inhibits proliferation, whereas beta(1A) promotes it. We investigated the ability of beta(1C) and beta(1A) to modulate integrin-mediated signaling events that affect cell proliferation and survival in Chinese hamster ovary stable cell lines expressing either human beta(1C) or human beta(1A). The different cytodomains of either beta(1C) or beta(1A) did not affect either association with the endogenous alpha(2), alpha(V), and alpha(5) subunits or cell adhesion to fibronectin or TS2/16, a mAb to human beta(1). Upon engagement of endogenous and exogenous integrins by fibronectin, cells expressing beta(1C) showed significantly inhibited extracellular signal-regulated kinase (ERK) 2 activation compared with beta(1A) stable cell lines. In contrast, focal adhesion kinase phosphorylation and Protein Kinase B/AKT activity were not affected. Selective engagement of the exogenously expressed beta(1C) by TS2/16 led to stimulation of Protein Kinase B/AKT phosphorylation but not of ERK2 activation; in contrast, beta(1A) engagement induced activation of both proteins. We show that Ras activation was strongly reduced in beta(1C) stable cell lines in response to fibronectin adhesion and that expression of constitutively active Ras, Ras 61 (L), rescued beta(1C)-mediated down-regulation of ERK2 activation. Inhibition of cell proliferation in beta(1C) stable cell lines was attributable to an inhibitory effect of beta(1C) on the Ras/MAP kinase pathway because expression of activated MAPK kinase rescued beta(1C) antiproliferative effect. These findings show that the beta(1C) variant, by means of a unique signaling mechanism, selectively inhibits the MAP kinase pathway by preventing Ras activation without affecting either survival signals stimulated by integrins or cellular interactions with the extracellular matrix. These findings highlight a role for beta(1)-specific cytodomain sequences in maintaining an intracellular balance of proliferation and survival signals.
Watermarking integer linear programming solutions (2002)

Linear programming (LP) in its many forms has proven to be an indispensable tool for expressing and solving optimization problems in numerous domains. We propose the first set of generic watermarking techniques for integer-LP (ILP). The proof of authorship by watermarking is achieved by introducing additional constraints to limit the solution space and can be used as effective means of intellectual property protection (IPP) and authentication. We classify and analyze the types of constraints in the ILP watermarking domain and show how ILP formulations provide more degrees of freedom for embedding signatures than other existing approaches. To demonstrate the effectiveness of the proposed ILP watermarking techniques, the generic discussion is further concretized using two examples, namely Satisfiability and Scheduling.
Potentiometric dissolved oxygen sensor using proton conductors. (1987)

プロトン導電性固体電解質(Sb2O5.4H20,Zr(HPO4)2.H20,ナフィオン膜)を用いてつぎのような.基本的構造をもつ固体電池を構成し,電位検出型溶存酸素センサーとしての応答特性について検討した。本素子では常温においても,起電力が気相酸素および水中溶存酸素の濃度の対数にほぼ比例するNernst式を満足する応答を示すことがわかった。90%応答時間は,水中溶存酸素濃度が4から40ppmの変化に対して25℃ で約10分,70℃で約5分であった。また,素子起電力は過酸化水素濃度の対数とも直線関係を示した。得られた各Nernst,勾配から,本素子の検知極上では酸素および過酸化水素に関していずれも2電子を含むつぎのような電極反応が起こっていると考えられる。.本素子の起電力は,pH4～10において,また溶存イオン種(K+,NO3-,Cl-)の濃度が10-4mol.dm-3以下であればほぼ一定値を示したが,これ以外のpHおよび濃度領域では変化した。
Calculation of eddy-current losses in toroidal-field-coil casing (1981)

A procedure is presented for calculating eddy current losses in circular and rectangular coil case cross sections. The procedure may be applied to toroidal field coil cases in pulsed tokamak systems, where eddy currents are induced by the time-varying magnetic fields which result from pulsing of the poloidal field coils. In circular cross sections, the procedure agrees well with a previously published method and is readily extended to the more realistic case of rectangular cross sections, which is addressed only approximately by the earlier method. The present procedure is applicable to thin- or thick-walled geometries, although considerable simplification is possible for thin-walled applications. In either case, closed form solutions may be readily applied.
Polarization Diversity-Enabled LOS/NLOS Identification via Carrier Phase Measurements (2023)

The provision of accurate localization is an increasingly important feature of wireless networks. To this end, a reliable distinction between line-of-sight (LOS) and non-LOS (NLOS) radio links is necessary to avoid degenerative localization estimation biases. Interestingly, LOS and NLOS transmissions affect the polarization of the received signals differently. In this work, we leverage this phenomenon to propose a threshold-based LOS/NLOS classifier exploiting weighted differential carrier phase measurements over a single link with different polarization configurations. Operation in either full or limited polarization diversity systems is possible. We develop a framework for assessing the performance of the proposed classifier, and show through simulations the performance impact of the reflecting materials in NLOS scenarios. For instance, the classifier is far more efficient in NLOS scenarios with wooden reflectors than in those with metallic reflectors. Numerical results evince the potential performance gains from exploiting full polarization diversity, properly weighting the differential carrier phase measurements, and using multi-carrier/tone transmissions. Finally, we show that the optimum decision threshold is inversely proportional to the path power gain in dB, while it does not depend significantly on the material of potential NLOS reflectors.
Near-Infrared Chiral Plasmonic Microwires through Precision Assembly of Gold Nanorods on Soft Biotemplates (2021)

Directing the assembly of plasmonic nanoparticles into chiral superstructures has diverse applications including, chiroptical sensing, nonlinear optics, and biomedicine. Though soft template-mediated assemblies of both spherical and nonspherical gold nanoparticles have made significant progress, most approaches require sophisticated chemical synthesis or advanced methodologies. Besides, reports of structurally precise chiral plasmonic assemblies beyond nanoscale are limited. Here, we propose an efficient yet simple strategy to grow such precision assemblies up to mesoscale, which is beneficial for a broader community. Briefly, cationic gold nanorods (AuNRs) are allowed to systematically assemble along atomically precise, chiral, rodlike tobacco mosaic virus (TMV) particles via electrostatic attraction under ambient condition. This leads to spontaneous formation of helical hybrid microwires with high structural precision, as evidenced by cryogenic transmission electron microscopy and tomography. Resulting composite superstructures show a strong circular dichroism response at the plasmon wavelength of the AuNRs, which is supported by simulations using discrete dipole approximation. Further, chirality of the system is investigated at a single-microwire level using polarized dark-field scattering microscopy. An alternative chiral template, negatively charged colloidal cellulose nanocrystals, also arrange AuNRs into similar chiral microstructures. Thus, our report proposes a generic methodology to obtain chiral plasmonic response at the NIR region using inexpensive templates that will encourage the exploration of a wider range of nanoscale templates for creating hybrid mesostructures with emerging optoelectronic properties.
Human Testicular Germ Cells, a Reservoir for Zika Virus, Lack Antiviral Response Upon Zika or Poly(I:C) Exposure (2022)

Zika virus (ZIKV) is an emerging teratogenic arbovirus that persists in semen and is sexually transmitted. We previously demonstrated that ZIKV infects the human testis and persists in testicular germ cells (TGCs) for several months after patients' recovery. To decipher the mechanisms underlying prolonged ZIKV replication in TGCs, we compared the innate immune response of human testis explants and isolated TGCs to ZIKV and to Poly(I:C), a viral RNA analog. Our results demonstrate the weak innate responses of human testis to both ZIKV and Poly(I:C) as compared with other tissues or species. TGCs failed to up-regulate antiviral effectors and type I IFN upon ZIKV or Poly(I:C) stimulation, which might be due to a tight control of PRR signaling, as evidenced by the absence of activation of the downstream effector IRF3 and elevated expression of repressors. Importantly, exogenous IFNβ boosted the innate immunity of TGCs and inhibited ZIKV replication in the testis <i>ex vivo</i>, raising hopes for the prevention of ZIKV infection and persistence in this organ.
A constructive view of GPSG or how to make it work (1988)

Using the formalism of generalized phrase structure grammar (GPSG) in an NL system (e.g. for machine translation (MT) is promising since the modular structure of the formalism is very well suited to meet some particular needs of MT. However, it seems impossible to implement GPSG in its 1985 version straightforwardly. This would involve a vast overgeneration of structures as well as processes to filter out everything but the admissible tree(s). We therefore argue for a constructive version of GPSG where information is gathered in subsequent steps to produce syntactic structures. As a result, we consider it necessary to incorporate procedural aspects into the formalism in order to use it as a linguistic basis for NL parsing and generation. The paper discusses the major implications of such a modified view of GPSG.
Diamond Resistives - The Passive Way to Manage the Heat and Keep the VSWR Low at High Frequencies (2019)

RF resistors able to operate above 8 GHz while handing > 100 W are critical for successful operation of phased array radar and 5G wireless infrastructure. Fabrication of high power resistors able to operate above S-Band requires reducing its parasitic electrical characteristics to a minimum. In this work it is demonstrated that this cannot be achieved with traditional substrates (A1N and BeO), but would be achievable by using CVD diamond. This will be illustrated primarily through the evaluation of resistor parameter “capacitance per watt”.
The Binary System Isotactic Polypropylene/Bis(3,4-dimethylbenzylidene)sorbitol:  Phase Behavior, Nucleation, and Optical Properties (2003)

The phase behavior of the binary system consisting of the commercial nucleating and clarifying agent 1,3:2,4-bis(3,4-dimethyldibenzylidene)sorbitol (DMDBS, Millad 3988) and isotactic polypropylene (i-PP) was investigated over the entire concentration range by means of differential scanning calorimetry (DSC), rheology, and optical microscopy. Experimental phase diagrams were constructed from data obtained in melting and crystallization studies, and a simple binary monotectic is advanced. Distinct regimes in the phase diagram, which apparently dictate nucleation and clarification of i-PP by DMDBS, are discussed. A maximum increase in the crystallization temperature of i-PP due to the nucleating action of DMDBS was observed in compositions containing between 0.2 and 1 wt % of the latter. Liquid−liquid phase separation was observed at elevated temperatures for i-PP/DMDBS mixtures comprising more than 2 wt % of DMDBS. A study of the optical properties of the i-PP/DMDBS system revealed that values for haze and clarity of injection-molded plaques progressively decreased and increased, respectively, in the concentration range between 0.2 and 1 wt % DMDBS in i-PP; at DMDBS concentrations exceeding 1 wt % the presence of the additive had an adverse effect on the optical properties of i-PP. Finally, a surprisingly strong influence of cooling kinetics on the phase behavior and, consequently, on the optical properties of the i-PP/DMDBS system was detected, which is of obvious relevance for industrial applications.
Recent diagnostic modalities for bladder cancer. (1990)

Recent advances in hybridoma technology, immunohistochemistry, cytopathology, cytogenetics, and molecular biology have not only furthered our understanding of the biology of bladder cancer but are also beginning to find clinical applications in the early diagnosis of the disease. It is likely that further study and refinement of these tools could reliably identify patients with superficial bladder tumors who are at increased risk for subsequent muscle infiltrative disease, or patients whose tumors are not amenable to current front-line chemotherapy.
Compact Silicon Nitride Interferometer (2021)

We demonstrate a silicon nitride interferometer with waveguides having different effective indexes instead of lengths to avoid waveguide bends, reduce losses and footprint.
Spinning of hydroalcoholic chitosan solutions (2013)

We investigated the spinning of hydroalcoholic chitosan solutions. The dope composition was optimized in order to obtain a continuous alcogel fiber by water evaporation on heating the extruded hydroalcoholic solution. This alcogel fiber was then neutralized in aqueous alkali baths and washed in water to eliminate the residual alcohol and salts before final drying. Depending on the alcohol content in the filament at the neutralization step, on specific alcohol-chitosan interactions and on the nature and concentration of the coagulation base, the process yielded semicrystalline chitosan fibers with different proportions of anhydrous and hydrated allomorphs. Contrarily to the classical annealing method, the formation of mainly anhydrous crystals was obtained without significant molecular weight decrease by neutralizing the polymer in hydrophobic conditions. The control of allomorph content was shown to be related to the hydrophobicity of the solvent (alcohol fraction) at the neutralization step.