gebhart/patrepeval huggingface dataset:
Ab initio-based Approach to Structural Stability of GaAs Surfaces (2003)

An ab initio-based approach was made to understand the influences of temperature and beam equivalent pressure (BEP) on the structural stability of GaAs surfaces. The theoretical approach incorporates free energy of vapor phase; therefore we can calculate how structural stability of GaAs surfaces depends on the temperature and beam equivalent pressure. By the theoretical investigations, temperature and BEP dependences of the stability of GaAs(001)-(4×2) β 2 were predicted. The results agree with experimental results, and feasibility of the theoretical approach was confirmed. Furthermore, the relative stability of Ga adatom among the case of that on GaAs(001)-(2&times4) β 2 and (11n)A (n = 2, 3 and 4) surfaces were studied. The results imply that Ga on (113)A is the most stable amongst (001) and all (11n)A surfaces. This is because the strain around the Ga adatom on (113)A is the smallest in the systems.
The Perks of Using Machine Learning for QoT Estimation with Uncertain Network Parameters (2020)

We compare the resilience to network parameters uncertainty between a GN-model based QoT tool and ML-based ones. We study the mean square error of the estimated G-OSNR and a novel metric based on the overestimation probability.
TSNA exposure from cigarette smoking: 18Years of urinary NNAL excretion data (2013)

The objective of this work was to characterize trends over time in urinary excretion of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) among cigarette smokers in the US. We identified 35 studies presenting data that either reported, or could be converted to, common units of total urinary NNAL excretion as pmol/mg creatinine. The studies spanned 18years, reported urinary NNAL excretion estimates for 61 defined populations, and included a combined total of 3941 study participants. Analyses show that urinary NNAL excretion trends downward with study publication year, and the trend is statistically significant. The trend does not appear to be accounted for by a reduction in cigarettes smoked per day by study participants over the same time period. This trend is consistent with reductions in tobacco specific nitrosamine (TSNA) levels in both cigarette tobacco filler and mainstream cigarette smoke observed over the past decade and with efforts by the tobacco industry and the agricultural community to reduce levels of TSNAs in tobacco and cigarette smoke.
The G Protein-Coupled Bile Acid Receptor, TGR5, Stimulates Gallbladder Filling (2011)

TGR5 is a G protein-coupled bile acid receptor present in brown adipose tissue and intestine, where its agonism increases energy expenditure and lowers blood glucose. Thus, it is an attractive drug target for treating human metabolic disease. However, TGR5 is also highly expressed in gallbladder, where its functions are less well characterized. Here, we demonstrate that TGR5 stimulates the filling of the gallbladder with bile. Gallbladder volume was increased in wild-type but not Tgr5(-/-) mice by administration of either the naturally occurring TGR5 agonist, lithocholic acid, or the synthetic TGR5 agonist, INT-777. These effects were independent of fibroblast growth factor 15, an enteric hormone previously shown to stimulate gallbladder filling. Ex vivo analyses using gallbladder tissue showed that TGR5 activation increased cAMP concentrations and caused smooth muscle relaxation in a TGR5-dependent manner. These data reveal a novel, gallbladder-intrinsic mechanism for regulating gallbladder contractility. They further suggest that TGR5 agonists should be assessed for effects on human gallbladder as they are developed for treating metabolic disease.
“Sugar-Cube”: Pedestrian Hardware Platform that Fits in the Sole of a Shoe (2023)

We report on the design, implementation, and demonstration of a miniaturized Inertial Navigation platform. The platform, with a total volume of 7.1 <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$cm^{3}$</tex> (excluding battery and case), includes the Inertial Measurement Unit (IMU), chip-scale barometer, magnetometer, as well as a powerful computational engine for signal processing and execution of the navigation algorithm. The sensors are integrated using separate PCBs with castellated edges forming the connections with the main board allowing some flexibility in sensor selection. The platform is small enough for integration in the sole of a shoe, which is an optimal location for implementation of Zero Velocity Update (ZUPT) algorithms for prolonged self-contained navigation. The navigation solution is performed using an Extended Kalman Filter (EKF) framework with an update rate of 500 Hz. A series of indoor walking experiments were conducted to verify the navigation accuracy of the platform which showed error 0.53% of the trajectory length for a 125 m, 2.75-minute duration walk including flat planes, stairs, and an elevator ride.
Murine and Human Myogenic Cells Identified by Elevated Aldehyde Dehydrogenase Activity: Implications for Muscle Regeneration and Repair (2011)

The methodology of isolating myogenic cells on the basis of elevated ALDH activity yielded cells with increased stress resistance, a behavior that conferred increased regenerative capacity of dystrophic murine skeletal muscle. This result demonstrates the critical role of stress resistance in myogenic cell therapy as well as confirms the role of ALDH as a marker for rapid isolation of murine and human myogenic progenitors for cell therapy.
Generalized model for the optical absorption edge ina-Si:H (1989)

We have reanalyzed the published optical absorption coefficient data for a-Si:H and introduced a divergence temperature, a new concept in the physics of these materials.Received 25 July 1988DOI:https://doi.org/10.1103/PhysRevB.39.1953©1989 American Physical Society
A 1700V-IGBT module and IPM with new insulated metal baseplate (IMB) featuring enhanced isolation properties and thermal conductivity (2016)

An enhanced module insulating technology IMB (Insulated Metal Baseplate) that features a high thermal conductivity and insulation properties and its application to IGBT module and IPM are presented. New IMB improves the thermal conductivity of the insulating resin layer by approximately 50% compared to the conventional IMB by optimization of powder particle and resin material. Thickness optimization realizes the best balance of heat resistance and insulation capabilities. This is the first IMB solution for 1700V module which requires high heat dissipation and insulation. It is also fitted for IPM application. We have successfully confirmed new IMB's heat resistance and insulation capabilities suitable for these applications.
Changes in polyphenol ability to produce astringency during roasting of cocoa liquor (2005)

Abstract Polyphenols in cocoa products determine the astringent sensation due to their interaction with salivary proline‐rich protein. Changes in the ability of polyphenols to produce astringency during cocoa roasting have been studied through an evaluation of the polyphenol–protein interaction in cocoa cake/liquor roasted at 120 °C for 45 min, with and without enrichment with polyphenol extract. Roasting decreased the capacity of polyphenols to interact with protein, causing a decrease in astringency. However, the polyphenol–protein interaction products after roasting could still be oxidized enzymatically and most probably would still give cocoa products beneficial effects as functional food. Copyright © 2005 Society of Chemical Industry
Validation of miniature ultrasonic transit-time flow probes for measurement of renal blood flow in rats (1995)

This study validates the accuracy of miniature ultrasonic transit-time flow probes for measuring renal blood flow (RBF) in the rat. Probes for 1-mm and 2-mm vessels were calibrated ex vivo using excised arteries at varying flow rates and hematocrit (Hct). Correlation between measured and true flow rates for the 2-mm probe were identical (r = 1.0) at both normal and subnormal Hct values. Correlation for the 1-mm probe was high (r = 0.994) at normal Hct, but varied at both high flow rates and subnormal Hct values. In vivo correlation of RBF measurements using the 1-mm probe with the clearance and extraction of p-aminohippuric acid showed a high correlation (r = 0.84; n = 72, P < 0.0001) over a wide range of flow rates (0.5-21 ml/min) and Hct (36-74%). Zero flow levels remained steady, averaging -0.2 +/- 0.2 ml/min during occlusion in the living animal and -0.1 +/- 0.3 ml/min after exsanguination. This study shows that the ultrasonic transit-time flowmeter (1-mm and 2-mm probes) is a reasonably accurate and reliable method with which to measure RBF in the anesthetized, acute-instrumented rat.
ChemInform Abstract: Hydrogen Bond Directed Nitrile Oxide Cycloaddition Reactions of Allylic 2‐Amides. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Direct laser writing of resonant periodic nanostructures in thin light-emitting films of CdSe/CdZnS core/shell nanoplatelets (2022)

Core/shell CdSe/CdZnS nanoplatelets (NPLs) are a promising class of nanomaterials for lasing applications owing to their low thresholds and high stability of stimulated emission generation as compared with many other types of colloids. Moreover, they can be self-assembled into high-quality thin films by simple methods of deposition. However, the high throughput and reproducible methods for nanopatterning of such films for advanced light-emitting applications are still missing. In this work, we show direct laser writing on thin films assembled from CdSe/CdZnS NPLs using either spin-coating or the self-assembly method for the purpose of fabricating. Using theoretical calculations, we design the period of the structures to achieve high quality-factor optical modes in the emission band of NPLs. In these nanostructured NPL films, fabricated according to the design, we observe photoluminescence enhancement and directional outcoupling effects. The proposed approach holds great potential for LEDs with improved outcoupling and for distributed feedback lasers or lasers based on bound states in the continuum with directly written optical cavities.
Abstract 862: Purified recombinant Maspin is processed through the endosomal pathway in breast cancer cells. (2013)

Abstract Maspin (Mammary Serine Protease Inhibitor), a gene involved in mammary gland development and morphogenesis, has been shown to act as a tumor suppressor in multiple cancers by inhibiting the aggressive cancer cell phenotype. Recombinant Maspin (rMas) added to cell culture media is internalized by cancer cells and capable of recapitulating many of the effects of endogenously re-expressed Maspin in Maspin-null cancer cells, including the inhibition of cell invasion, migration and induction of angiogenesis. Importantly, these effects are mediated by purified rMas without the need for post-translational modifications prior to application, increasing the future therapeutic potential for utilizing rMas as an adjuvant therapy. However, the therapeutic use of rMas is limited by its rapid clearance from cancer cells, and many of the molecular mechanisms regarding rMas internalization and processing remain to be determined. Building on preliminary data, we hypothesized that rMas is processed by the endosomal pathway. We demonstrate localization of rMas in Rab9 late-endosomes and Lamp-1 positive lysosomes following treatment of 10 μg/ml rMas in BT549, Hs578T and MDA-MB-231 human breast cancer cell lines. rMas internalization was reduced when incubated at 4oC, and increased at temperatures of 20oC and 37oC, with the highest rates of internalization at 37oC, indicative of endocytosis. Furthermore, depletion of K+ decreased rMas internalization in Hs578T and MDA-MB-231, suggestive of clarthrin-mediated endocytosis. Our data show that rMas is capable of acting at the membrane to mediate effects on invasion and migration, but may not be functional once internalized due to rapid degradation by the lysosome. Interestingly, this may provide a plausible explanation for previously reported data in which rMas was not able to reproduce the effects of endogenous Maspin re-expression on cancer cell apoptosis sensitivity, which require cytosolic and mitochondrial mechanisms. Our data provide evidence that strategies which induce endosomal escape of rMas will intensify its anti-tumor effects on cancer cells, and further enhance its potential therapeutic applications. Citation Format: Thomas M. Bodenstine, Richard E. B. Seftor, Elisabeth A. Seftor, Zhila Khalkhali-Ellis, Nicole A. Samii, J. Cesar Monarrez, Philip A. Pemberton, Mary J. C. Hendrix. Purified recombinant Maspin is processed through the endosomal pathway in breast cancer cells. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 862. doi:10.1158/1538-7445.AM2013-862
(Invited) Preparation of Ordered through-Hole Membranes with Controlled Geometrical Structures By Two-Layer Anodization Processes (2020)

Ordered through-hole membranes, which have a unique geometrical structure composed of hexagonally arranged array of straight holes with uniform diameters, have attracted growing interest owing to its various applications such as filtration membranes, sensors, and templates. Anodization process of metals is an effective method for the preparation of ordered hole array structures of metal oxides. One advantageous point of this process is controllability of the geometrical structures of the obtained porous oxides based on the anodization conditions [1]. In addition, the naturally occurring self-ordered ordered nanoporous structures can be obtained under the appropriate anodization conditions. In our previous work, we reported a high-throughput process for the preparation of ordered alumina through-hole membranes by two-layer anodization using concentrated sulfuric acid [2-4]. In this process, the second highly soluble alumina layer is formed under the first porous alumina layer by the anodization of samples in concentrated sulfuric acid. The porous alumina through-hole membrane can be obtained by selective dissolution of the second alumina layer formed in concentrated sulfuric acid. This process allows repeated preparation of ordered through-hole membranes from a single metal substrate by repetition of the process. Based on this process, ordered TiO 2 through-hole membranes were also obtained using an electrolyte containing fluoride ions[5]. The hole period of the obtained TiO 2 membranes could be controlled by changing the anodizing voltage. In the present report, preparation of various types of metal oxide through-hole membranes will be presented. For example, the preparation of ideally ordered TiO 2 through-hole membranes by the combination process of two-layer anodization and pretexturing of Ti was described. H. Masuda and K. Fukuda, Science , 268 , 1466 (1995). T. Yanagishita and H. Masuda, Electrochim. Acta , 184 , 80 (2015). T. Yanagishita, A. Kato, T. Kondo, and H. Masuda, Jpn. J. Appl. Phys ., 56 , 035202 (2017). T. Yanagihsita, A. Kato, T. Kondo, and H. Masuda, Jpn. J. Appl. Phys ., 59 , 038002 (2020). T. Yanagishita, H. Inada, T. Kondo, N. T. Nguyen, P. Schmuki, and H. Masuda, J. Electrochem. Soc. , 165 , E763 (2018).
Nanoparticulate carriers: an emerging tool for breast cancer therapy (2014)

Breast cancer is a leading cause of death for women in the world. Cancer has the potential to spread to different organs around the body, and form metastases that can even develop after surgical removal of the primary tumour. Nanotechnology offers new promising strategies for the treatment of breast cancer, and has emerged as a powerful tool for fighting cancer. Nanoparticles can be fabricated to perform more than one task simultaneously, and can have a number of roles, such as acting as a therapeutic agent, drug delivery vehicle and/or tumour imaging agent. This review will focus on various forms of nanoparticles serving as potential agents for cancer therapeutics, illustrating their use in breast cancer therapies. This article also highlights the properties, current progress in the design and engineering of nanoparticles.
Einleitung (2022)

No AccessSaechtling Kunststoff-HandbuchOct 2022EinleitungErwin Baur, Dietmar Drummer, Tim A. Osswald, Natalie RudolphErwin BaurSearch for more papers by this author, Dietmar DrummerSearch for more papers by this author, Tim A. OsswaldSearch for more papers by this author, Natalie RudolphSearch for more papers by this authorhttps://doi.org/10.3139/9783446473614.002SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2022Pages: 13-45Print ISBN: 978-3-446-46514-5eISBN: 978-3-446-47361-4 Copyright & Permissions© 2022 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
Deep cryogenic operation of 55 nm CMOS SPADs for quantum information and metrology applications (2021)

We demonstrate the operation and study the performance metrics of advanced CMOS single-photon avalanche diodes from 293K down to 3K. This shows their potential for close integration with quantum devices operating at cryogenic temperatures.
Unicompartmental versus Total Knee Arthroplasty in the Same Patient (2008)

Purpose: To compare the clinical and radiographic results of unicompartmental knee arthroplasty (UKA) and total knee arthroplasty (TKA) in the same patient, and to investigate patient preference and satisfaction. Materials and Methods: Among the 56 patients who underwent a UKA in one knee and a TKA in the opposite knee between January 2002 and December 2004, 51 patients were followed up. The average follow-up period was 4 years. Results: The average Knee Society Score (KSS) improved from 53.5 preoperatively to 90.7 at last follow-up in the UKA knee, and from 50.4 to 89.8 in the TKA knee. The mean range of knee motion also improved from 124.7˚ to 133.2˚ in the UKA knee, and from 122.5˚ to 127.1˚ in the TKA knee. The tibiofemoral angle changed from 0.3˚ of varus to 5.6˚ of valgus in the UKA knee, and from 2.4˚ of varus to 5.8˚ of valgus in the TKA knee. For patient preference, 23 patients (45%) preferred the UKA knee and 19 patients (37%) preferred the TKA knee. Most patients (42 patients, 82%) reported being ‘very satisfied' or ‘satisfied' with both knees. Conclusion: The clinical and radiographic results of both the UKA and the TKA in the same patient were satisfactory at the 4-year follow-up. The UKA knee had a slightly better range of knee motion, but there was essentially no difference between the UKA knee and the TKA knee.
Analyse de la synchronisation des oscillateurs par la méthode de l'équilibrage spectral (1993)

International audience
Quantitative Analysis of Neutralizing Immune Responses to Human Parvovirus B19 Using a Novel Reverse Transcriptase–Polymerase Chain Reaction–Based Assay (1999)

Infection with human parvovirus B19 causes fifth disease, acute and chronic red cell aplasia, fetal hydrops, arthropathy, and other disorders. Antiviral antibodies limit B19 infection in vivo; however, the identification of serologic markers of protection has been hampered by the lack of a quantitative assay for parvovirus neutralization. A novel in vitro test for parvovirus neutralization has been developed using reverse transcriptase-polymerase chain reaction to detect viral transcripts in a B19-permissive cell line. Parvovirus neutralizing activity was measured in sera from naturally infected individuals, and common features of sera with high neutralizing capacity were identified as protection correlates. Sera that suppressed B19 replication in vitro demonstrated IgG reactivity with capsid proteins VP1 and VP2, but no linear relationship between antibody titer and neutralizing capacity was observed. Sera from experimental animals and human volunteers immunized with a virus-like particle vaccine candidate exhibited B19 neutralizing titers equal to or greater than those observed in natural infections.
ChemInform Abstract: STEREOCHEMISTRY OF THE POLONOVSKI REARRANGEMENT (1973)

Abstract Aus den 1,4‐Benzodiazepin‐N‐oxiden (I) erhält man in Gegenwart des Säurechlorides (II) die Ester (III), aus denen (IV) hergestellt wird.
Nanostructured Lipid Carrier (NLC): A Promising Drug Delivery System (2017)

Journal of Nanomedicine (GJN) desires to deliver research and clinically reformative information globally. GJN is an open access, peer-reviewed, multidisciplinary, international medical journal published bimonthly by Juniper group.
Site-specific O-Glycosylation on the MUC2 Mucin Protein Inhibits Cleavage by the Porphyromonas gingivalis Secreted Cysteine Protease (RgpB) (2013)

The colonic epithelial surface is protected by an inner mucus layer that the commensal microflora cannot penetrate. We previously demonstrated that Entamoeba histolytica secretes a protease capable of dissolving this layer that is required for parasite penetration. Here, we asked whether there are bacteria that can secrete similar proteases. We screened bacterial culture supernatants for such activity using recombinant fragments of the MUC2 mucin, the major structural component, and the only gel-forming mucin in the colonic mucus. MUC2 has two central heavily O-glycosylated mucin domains that are protease-resistant and has cysteine-rich N and C termini responsible for polymerization. Culture supernatants of Porphyromonas gingivalis, a bacterium that secretes proteases responsible for periodontitis, cleaved the MUC2 C-terminal region, whereas the N-terminal region was unaffected. The active enzyme was isolated and identified as Arg-gingipain B (RgpB). Two cleavage sites were localized to IR↓TT and NR↓QA. IR↓TT cleavage will disrupt the MUC2 polymers. Because this site has two potential O-glycosylation sites, we tested whether recombinant GalNAc-transferases (GalNAc-Ts) could glycosylate a synthetic peptide covering the IRTT sequence. Only GalNAc-T3 was able to glycosylate the second Thr in IRTT, rendering the sequence resistant to cleavage by RgpB. Furthermore, when GalNAc-T3 was expressed in CHO cells expressing the MUC2 C terminus, the second threonine was glycosylated, and the protein became resistant to RgpB cleavage. These findings suggest that bacteria can produce proteases capable of dissolving the inner protective mucus layer by specific cleavages in the MUC2 mucin and that this cleavage can be modulated by site-specific O-glycosylation.
ChemInform Abstract: Recent Advances in the Development of Aryl‐Based Foldamers (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.