gebhart/patrepeval huggingface dataset:
Actinide Organometallic Chemistry (1982)

The stoichiometric and catalytic chemistry of metal-organic compounds having actinide-to-carbon bonds is in a stage of rapid growth. Chemical, structural, and bonding characteristics have been identified which differ in interesting and informative ways from those of d-block transition element compounds.
Genetic predictors of depressive symptoms in cardiac patients (2008)

Numerous studies suggest that the prevalence of depression is greater among cardiac patients than in the general population. However, little attention has been paid to the possibility of genetic contributions to depressive symptoms in cardiac patients. We conducted a candidate gene study focusing on genes related to inflammation, platelet aggregation, endothelial function and omega-3 fatty acid metabolism as predictors of depressive symptoms among 977 participants with established cardiovascular disease. Results suggested that genetic variation related to endothelial dysfunction is predictive of depressive symptoms and that endothelial dysfunction may be a novel mechanism contributing to depressive symptoms among cardiac patients.
A NOVEL METHOD FOR ACCURATE DETERMINATION OF KNEE PROSTHESIS SIZING IN TKA NAVIGATION (2014)

Clinical outcomes for total knee arthroplasty (TKA) are sensitive to lower extremity alignment, implant positioning, and implant size. Accurate determination of femoral implant size is the focus of this paper. As existing methods (conventional instrumentation, preoperative images, navigation) can be limited by issues including inaccuracy, time required, exposure, and cost, this study assesses a novel method for determining femoral component size using navigation. We used a commercially available navigation system (Exactech GPS, Blue Ortho, Grenoble, FR, with Total Knee V1.13 software). The system uses surface patches to collect small point clouds, and then computes points that match a given criteria (e.g. the most distal point). For femoral component sizing, the proposed method automatically defines a target area to be digitised on the anterior cortex. To do this, the surgeon acquires anatomical landmarks (i.e., knee centre, distal condyles, etc.) for all femoral implant parameters but the size. The surgeon then moves the tip of the acquisition instrument near the anterior cortex, and the system computes the distance between the virtual posterior cut and the tip in real time. The theoretical implant size increases in real time as the instrument tip moves anteriorly and decreases as it moves posteriorly. The target area is displayed on the anterior cortex such that it covers all the bone in the medio-lateral direction, is centred on the most proximal part of the theoretical implant in the proximal-distal direction, and covers the current size plus or minus one size. As a result, the target area virtually moves in the proximal-distal direction as the surgeon moves the instrument tip closer to the anterior cortex surface. When the tip is in contact with the anterior surface, acquisition of the point cloud is performed. From a user point of view, the system does not move the target area relative to the bone on the display, but instead adjusts the relative position of the instrument tip, creating the impression that no matter the bone size, the target area does not move and the instrument tip is always guided to the right spot. The method has been successfully implemented and used on more than 1,400 patients. A preliminary analysis on 189 surgical reports shows in 188 cases (99,5%) the proximal point of the selected implant is inside the target area (which means that the selected size is the one by default, plus or minus one). We conclude the proposed method as implemented in the Exactech GPS has proven to be clinically effective. It can easily be extended to determination of other points when global criteria can be used to define an optimal area of digitisation determined from previously acquired data.
Left femoral arterial occlusion due to tumor embolism after left pneumonectomy; a case report. (1993)

症例は62歳の男性で, 感冒様症状にて近医を受診した際に, 胸部異常陰影を指摘され, 当院に紹介された.精査の結果, 左B1+2原発の低分化腺癌 (cT3N1M0 stageIIIA) と診断した.肺動脈造影の静脈相では上肺静脈は描出されなかった.左肺全摘術を施行した.上肺静脈は視触診にて浸潤なしと判断したが, 念のため心嚢内で処理した.術後, 麻酔よりの覚醒は良好で, 気管内チューブ抜管後ICUへ入室した.約2時間後, 左下肢に冷感が著明となり, 急性浅大腿動脈塞栓症として手術をしたところ, 腫瘍塊による塞栓症であった.腫瘍塞栓は肺癌の希な合併症であるが, 死亡率が高く重篤となりえる.肺癌の肺静脈本幹への浸潤はその確定が困難である.報告された27例と自験例の検討により, 比較的大型の低分化癌で, 肺門に連続している場合には, 肺静脈までの浸潤の可能性を考慮すべきであると思われた.
Model-based color manipulation (2007)

The manipulation of the colors in an image and color spaces in general can be highly complex and non-intuitive. Converting the thoughts or vision of the designer to specific color modifications on an image is hard, while envisioning the effect of a specific color manipulation is difficult as well. Furthermore, recoloring must take into account spatial image considerations along with the color constraints. We introduce a method that models possible color manipulations of an image by a structured search space. We utilized the design galleries metaphor to present the designer with an interface for navigating this search space toward a desired target color variation. The pixels' colors are modeled by a spatially-constrained Gaussian mixture model of the chroma channels, and the search space is defined by applying affine transformations to the parameters of this model. This approach provides both inspiration and intuitive navigation in the complex space of image color manipulations.
Insulin-Mediated Glucose Disposal in Type I Diabetes: Evidence for Insulin Resistance (1983)

To clarify whether type I diabetes is characterized by insulin resistance, insulin-mediated glucose metabolism (M; milligrams per kg/min) was estimated by means of the glucose clamp technique in five insulin-dependent diabetic patients and six normal subjects. Three glucose clamps were carried out under different metabolic conditions. Free insulin plateaux were similar during each clamp in both groups. The first clamp was performed in normal subjects after an overnight fast [blood glucose, 80 +/- 3 mg/dl (mean +/- SEM)] and in diabetic patients 18 h after insulin withdrawal (blood glucose, 366 +/- 47 mg/dl). Diabetic patients had a M value (4.25 +/- 0.74) not different from normals (5.38 +/- 0.63; P = NS). The second clamp was done with the same glycemic values (approximately 125 mg/dl) in both groups. M increased to 8.07 +/- 1.06 (P less than 0.01) in the normal subjects and decreased to 2.87 +/- 0.50 (P = NS) in the diabetic patients. The M value in the diabetic patients was lower than that in the normal subjects (P less than 0.05). The third clamp was performed in three diabetic patients after 1 month of treatment with continuous sc insulin infusion. The mean blood glucose level was 88 +/- 6 mg/dl, and M was 3.23 +/- 0.38, significantly lower than that of the normal subjects in the basal state (P less than 0.05). No differences were found in insulin binding to erythrocytes. The mean plasma clearance rate (milliliters per m2/min) of free insulin was the same in both groups (428 +/- 113 in normal subjects and 354 +/- 83 in diabetic patients). Basal endogenous glucose production was higher in the diabetics (3.13 +/- 0.48 mg/kg X min) than in the normal subjects (1.71 +/- 0.57). During the clamp, however, endogenous glucose production was similarly inhibited (approximately 95%) in both groups. Multiple glucose clamp studies were also performed at three different insulin infusion rates (21, 73, and 760 mU/m2 X min, respectively) to generate an insulin-dose response curve for glucose disposal in six diabetic patients treated with continuous sc insulin infusion for at least 6 months. This allowed investigation of the effect of chronic strict insulin therapy leading to normal glucose and intermediary metabolite levels and identification of the cellular mechanism of insulin resistance. A significant reduction of the maximal glucose disposal rate (10.7 +/- 0.5 mg/kg X min) was found in these diabetic patients compared to that in normal subjects (14.9 +/- 1.0; P less than 0.05).(ABSTRACT TRUNCATED AT 400 WORDS)
Characterization of high-molar-mass fractions in a Scots pine (Pinus sylvestris L.) knotwood ethanol extract (2017)

Abstract The identification of compounds in Scots pine ( Pinus sylvestris L.) knotwood (KnW), obtained by extracting with hydrophilic organic solvents, has been performed previously almost exclusively by gas chromatography-mass spectrometry (GS-MS) equipped with long GC columns (≥25 m). That means that the molar mass (MM) of the majority of the identified compounds was below 500–600 Da, and the analytical data accounted for only about half of the dry extract weight. In the present work, high-molar-mass (HMM) fractions in a Scots pine KnW-EtOH extract were isolated and chemically characterized by means of several advanced analytical techniques, such as high performance size-exclusion chromatography-evaporative light scattering detector (HPSEC-ELSD), high performance liquid chromatography (HPLC)-electrospray ionization-ion trap-mass spectrometry [(HPLC)ESI-IT-MS], ESI-quadrupole time of flight-mass spectrometry (QTOF-MS), pyrolysis-gas chromatography-mass spectrometry (Py-GC-MS), thermally assisted hydrolysis and methylation-gas chromatography-mass spectrometry (THM-GC-MS), nuclear magnetic resonance (NMR) and GC-MS. The results indicate that the MM maxima of the HMM fractions ranged from approximately 500 to 2200 Da, and that the compounds consist mainly of oligomers of hydroxylated resin acids (RAs), especially dehydroabietic acid, but also of fatty acids (FAs), stilbenes and sterols. A large number of RA dimers were tentatively identified in the HMM fractions. However, it remains unknown how the monomer units are linked together, as it was not possible to isolate a RA dimer fraction pure enough for NMR characterization. RA dimers in native KnW have not been identified previously.
Local-global neural networks: a new approach for nonlinear time series modelling (2003)

In this paper, the Local Global Neural Networks model is proposed within the context of time series models. This formulation encompasses some already existing nonlinear models and also admits the Mixture of Experts approach. We place emphasis on the linear expert case and extensively discuss the theoretical aspects of the model: stationarity conditions, existence, consistency and asymptotic normality of the parameter estimates, and model identifiability. A model building strategy is also considered and the whole procedure is illustrated with two real time-series.
Comparison of the In Vivo Pharmacokinetics and In Vitro Dissolution of Branded Versus Generic Efavirenz Formulation in HIV-Infected Patients (2016)

Gervasoni, Cristina MD; Baldelli, Sara ChemD; Cerea, Matteo PhD; Cenderello, Giovanni MD; Bini, Teresa MD; Vimercati, Stefania PharmD; Iardino, Rosaria; Gazzaniga, Andrea PharmD; D'Arminio Monforte, Antonella MD; Clementi, Emilio PhD; Cattaneo, Dario PhD Author Information
Reliable lower bound for number of calling marine mammals in Chukchi Sea (2019)

A reliable lower bound is derived for the number of vocalizing bowhead whales and walruses in the Chukchi Sea from ten acoustic receivers deployed during NOAA's CHAOZ experiment in 2011. The lower bound is derived from extremely reliable 100% confidence intervals (CI) of the sound's locations. CI are derived from measurements of the Time Differences of Arrival (TDOA) of sound between receivers. Sequential Bound Estimation (SBE) is used to estimate the CI by assimilating the TDOA. SBE was successfully and independently evaluated by the U.S. Navy. It is a nonlinear non-Bayesian technique capable of explicitly accounting for all errors affecting uncertainty while being computationally efficient. To date, its CI always contain the true location of the source. The CI are affected by uncertainty of sound speed, TDOA, receiver location, and clock time. For two-dimensional models of location, i.e., longitude/latitude, it appears necessary to utilize isodiachrons instead of hyperbolas to obtain reliable CI because of the extreme non-homogeneity of sound speed needed to obtain correct location. [Supported by the North Pacific Research Board and Microsoft.]
Coherent Combining of a 1.26-kW Fiber Amplifier (2010)

A 1.26-kW, multi-stage Yb fiber MOPA was coherently combined using active polarization and phase control with 94% visibility to a second fiber amplifier, consistent with estimated decoherence effects from fiber nonlinearity, linewidth, and phasing accuracy.
Hole transport material for electrochemical or optoelectronic devices (2016)

ES 2575511 A1 20160629 â¢\tThe present invention relates to novel compds., methods of prepg. the compds. and uses of the compds. as hole transport materials in optoelectronic devices or electrochem., and methods of producing devices.
Scalable fabrication of micron-scale graphene nanomeshes for high-performance supercapacitor applications (2016)

GNM electrodes exhibit superior electrochemical properties.
Compression of Lactose, Glucose and Mannitol Granules (1995)

The effect of the amount of granulation liquid, compression speed and maximum compression force on then compressibility and compactibility of lactose, glucose and mannitol granules was studied. The porosity based on the geometrical shape and the uniformity of weight of tablets was also studied. Lactose and mannitol granules showed a greater compressibility than glucose granules. Mannitol granules produced the hardest tablets and lactose and glucose the weakest. The change in the amount of granulation liquid caused changes both in the granule porosity and in the amount of binder; this was attributed to differences in tablet strength. All parameters studied were relatively insensitive to changing speeds of compression in the range used, except for the breaking force of mannitol tablets, which was greatest with the lowest speed of compression. All granule masses showed a relatively good continuous flow suitable for table production. Tablets compressed from lactose granules had the best uniformity of weight of the tablets studied.
Proton-Assisted Recoupling (PAR) in Peptides and Proteins (2017)

Proton-assisted recoupling (PAR) is examined by exploring optimal experimental conditions and magnetization transfer rates in a variety of biologically relevant nuclear spin-systems, including simple amino acids, model peptides, and two proteins-nanocrystalline protein G (GB1), and importantly amyloid beta 1-42 (M<sub>0</sub>Aβ<sub>1-42</sub>) fibrils. A selective PAR protocol, SUBPAR (setting up better proton assisted recoupling), is described to observe magnetization transfer in one-dimensional spectra, which minimizes experiment time (in comparison to two-dimensional experiments) and thereby enables an efficient assessment of optimal PAR conditions for a desired magnetization transfer. In the case of the peptide spin systems, experimental and simulated PAR data sets are compared on a semiquantitative level, thereby elucidating the interactions influencing PAR magnetization transfer and their manifestations in different spin transfer networks. Using the optimum Rabi frequencies determined by SUBPAR, PAR magnetization transfer trajectories (or buildup curves) were recorded and compared to simulated results for short peptides. PAR buildup curves were also recorded for M<sub>0</sub>Aβ<sub>1-42</sub> and examined conjointly with a recent structural model. The majority of salient cross-peak intensities observed in the M<sub>0</sub>Aβ<sub>1-42</sub> PAR spectra are well-modeled with a simple biexponential equation, although the fitting parameters do not show any strong correlation to internuclear distances. Nevertheless, these parameters provide a wealth of invaluable semiquantitative structural constraints for the M<sub>0</sub>Aβ<sub>1-42</sub>. The results presented here offer a complete protocol for recording PAR <sup>13</sup>C-<sup>13</sup>C correlation spectra with high-efficiency and using the resulting information in protein structural studies.
Role of Magnesium and Calcium in Alcohol‐Induced Hypertension and Strokes as Probed by In Vivo Television Microscopy, Digital Image Microscopy, Optical Spectroscopy, 31P‐NMR, Spectroscopy and a Unique Magnesium Ion‐Selective Electrode (1994)

It is not known why alcohol ingestion poses a risk for development of hypertension, stroke and sudden death. Of all drugs, which result in body depletion of magnesium (Mg), alcohol is now known to be the most notorious cause of Mg-wasting. Recent data obtained through the use of biophysical (and noninvasive) technology suggest that alcohol may induce hypertension, stroke, and sudden death via its effects on intracellular free Mg2+ ([Mg2+]i), which in turn alter cellular and subcellular bioenergetics and promote calcium ion (Ca2+) overload. Evidence is reviewed that demonstrates that the dietary intake of Mg modulates the hypertensive actions of alcohol. Experiments with intact rats indicates that chronic ethanol ingestion results in both structural and hemodynamic alterations in the microcirculation, which, in themselves, could account for increased vascular resistance. Chronic ethanol increases the reactivity of intact microvessels to vasoconstrictors and results in decreased reactivity to vasodilators. Chronic ethanol ingestion clearly results in vascular smooth muscle cells that exhibit a progressive increase in exchangeable and cellular Ca2+ concomitant with a progressive reduction in Mg content. Use of 31P-NMR spectroscopy coupled with optical-backscatter reflectance spectroscopy revealed that acute ethanol administration to rats results in dose-dependent deficits in phosphocreatine (PCr), the [PCr]/[ATP] ratio, intracellular pH (pHi), oxyhemoglobin, and the mitochondrial level of oxidized cytochrome oxidase aa3 concomitant with a rise in brain-blood volume and inorganic phosphate. Temporal studies performed in vivo, on the intact brain, indicate that [Mg2+]i is depleted before any of the bioenergetic changes. Pretreatment of animals with Mg2+ prevents ethanol from inducing stroke and prevents all of the adverse bioenergetic changes from taking place. Use of quantitative digital imaging microscopy, and mag-fura-2, on single-cultured canine cerebral vascular smooth muscle, human endothelial, and rat astrocyte cells reveals that alcohol induces rapid concentration-dependent depletion of [Mg2+]i. These cellular deficits in [Mg2+]i seem to precipitate cellular and subcellular disturbances in cytoplasmic and mitochondrial bioenergetic pathways leading to Ca2+ overload and ischemia. A role for ethanol-induced alterations in [Mg2+]i should also be considered in the well-known behavioral actions of alcohol.
Hard Contact With A Force-Reflecting Teleoperator (1990)

Force feedback adjusted to provide stability without sluggish and fatiguing operation. Paper reports on experiments with single-axis force-reflecting teleoperator that made contact with hard, immovable object. Experiments show that dynamics of human operator affect stability of response of control system.
Early protein intake predicts functional connectivity and neurocognition in preterm born children (2021)

Nutritional intake can promote early neonatal brain development in very preterm born neonates (< 32 weeks' gestation). In a group of 7-year-old very preterm born children followed since birth, we examined whether early nutrient intake in the first weeks of life would be associated with long-term brain function and neurocognitive skills at school age. Children underwent resting-state functional MRI (fMRI), intelligence testing (Wechsler Intelligence Scale for Children, 5th Ed) and visual-motor processing (Beery-Buktenica, 5th Ed) at 7 years. Relationships were assessed between neonatal macronutrient intakes, functional connectivity strength between thalamic and default mode networks (DMN), and neuro-cognitive function using multivariable regression. Greater functional connectivity strength between thalamic networks and DMN was associated with greater intake of protein in the first week (β = 0.17; 95% CI 0.11, 0.23, p < 0.001) but lower intakes of fat (β = - 0.06; 95% CI - 0.09, - 0.02, p = 0.001) and carbohydrates (β = - 0.03; 95% CI - 0.04, - 0.01, p = 0.003). Connectivity strength was also associated with protein intake during the first month (β = 0.22; 95% CI 0.06, 0.37, p = 0.006). Importantly, greater thalamic-DMN connectivity strength was associated with higher processing speed indices (β = 26.9; 95% CI 4.21, 49.49, p = 0.02) and visual processing scores (β = 9.03; 95% CI 2.27, 15.79, p = 0.009). Optimizing early protein intake may contribute to promoting long-term brain health in preterm-born children.
Appendix A: Probability Distributions (2011)

This appendix contains sections titled: Introduction Beta Distribution Binomial Distribution Cauchy Distribution Chi-Squared Distribution Erlang Distribution Exponential Distribution Exponential Power Distribution F-Distribution Gamma Distribution Geometric Distribution Laplace Distribution Normal (Gaussian) Distribution Poisson Distribution t (Student's) Distribution Uniform (Rectangular) Continuous Distribution Weibull Distribution Tables of Distributions
Comments on "Exact solutions of electromagnetic fields in both near and far zones radiated by thin circular-loop antennas: a general representation" [with reply] (2001)

For original article by L.W. Li et al. see ibid., vol.45, no.12, p.1741-8 (Dec. 1997).
Correction to “A Power-Efficient 32 bit ARM Processor Using Timing-Error Detection and Correction for Transient-Error Tolerance and Adaptation to PVT Variation” (2011)

In the above titled paper (ibid., vol. 46, no. 1, pp. 18-31, Jan. 11), Fig. 12 was printed incorrectly. The correct figure is presented here.
Characterization of Silicon Carbon Nitride for Low Temperature Wafer-to-Wafer Direct Bonding (2020)

Silicon carbon nitride (SiCN) compounds have aroused great interest as dielectric materials for direct bonding because of the high thermal stability and high bond strength, as well as its Cu diffusion barrier properties. While wafer-to-wafer direct bonding, including the dielectric deposition step, is generally performed at high temperature (&gt;350°C), applications such as heterogeneous chips and DRAMs would require wafer-to-wafer direct bonding at lower temperature (&lt;250°C). In this study, we evaluate, for SiCN deposited at various temperatures, the impact for direct wafer bonding of lowering the temperature of all processes. Chemical and mechanical properties of SiCN direct bonding are studied.
Differential modulation of E. coli mRNA abundance by inhibitory proteins that alter the composition of the degradosome (2006)

In Escherichia coli the initial step in the processing or decay of many messenger and structural RNAs is mediated by the endonuclease RNase E, which forms the core of a large RNA-catalysis machine termed the degradosome. Previous experiments have identified a protein that globally modulates RNA abundance by binding to RNase E and regulating its endonucleolytic activity. Here we report the discovery of RraB, which interacts with a different site on RNase E and interferes with cleavage of a different set of transcripts. We show that expression of RraA or RraB in vivo is accompanied by dramatic, distinct, and inhibitor-specific changes in degradosome composition--and that these are in turn associated with alterations in RNA decay and global transcript abundance profiles that are dissimilar to the profile observed during simple RNase E deficiency. Our results reveal the existence of endonuclease binding proteins that modulate the remodelling of degradosome composition in bacteria and argue that such degradosome remodelling is a mechanism for the differential regulation of RNA cleavages in E. coli.