gebhart/patrepeval huggingface dataset:
Magnetooptic spatial light modulator characterization (1989)

Two-dimensional spatial light modulators are critical components in coherent optical data and image processing systems. A laboratory characterization system has been developed and used to examine a magnetooptic SLM. The system relies on a minicomputer interface providing individual SLM pixel control, an optical multichannel analyzer, and a Mach-Zehnder interferometer to characterize polarization rotation, contrast ratio, amplitude transmittance, phase stability, and switching effects associated with neighboring pixels. The results have shown the magnitude of the polarization rotation and the achievable contrast ratio are dependent on the size of the illumination area. Three distinct polarization rotations and contrast ratios, within a pixel, within the frame, and full frame, were found to be needed to characterize the device. Within a pixel illumination provided the largest polarization rotation and highest contrast ratio. Analysis has shown that device performance can be described by a model based on the coherent addition of polarization rotated and unrotated transmitted light. The amplitude and phase properties of the light transmitted by the device proved to be very stable in a variety of operating conditions.
D-Band Silica-Based Package Substrate With EBG Structure for Flip-Chip Modules (2019)

This paper presents a silica-based package substrate for flip-chip modules in D-band. An electromagnetic band-gap (EBG) structure is adopted in the substrate in order to suppress degradation of flipped IC performance due to parasitic propagation modes. By introducing a trench in the EBG structure, the structure can work in higher frequencies without thinning the substrate. A 150-GHz-band up-converter IC is mounted on the substrate by flip-chip bonding. No degradation is observed in RF performance compared with the unflipped one.
Novel slot antennas for harmonic suppression (2004)

In this paper, novel microstrip-fed slot antennas with simple structure are proposed to achieve suppression of harmonics. To obtain this operation, conductor lines connected with ground plane in rectangular and meander type slot antennas are used, which have wide-bandstop characteristic. From the measured input impedances and radiation patterns of the proposed antennas, the second and third harmonics are effectively suppressed.
Disease-free (DFS) and overall survival (OS) at 3.4 years (yrs) for neoadjuvant bevacizumab (Bev) added to docetaxel followed by fluorouracil, epirubicin and cyclophosphamide (D-FEC), for women with HER2 negative early breast cancer: The ARTemis trial. (2016)

1014 Background: ARTemis compared the addition of Bev to neoadjuvant D-FEC in HER2 negative breast cancer. Improved pathological complete response (pCR) with Bev has been reported previously. Methods: We enrolled women ≥ 18 yrs with radiological tumour size > 20mm, ± axillary involvement, at 66 centres in the UK. Patients (pts) were randomly assigned to 3 cycles of D (100 mg/m² every [q] 21 days [d]) followed by 3 cycles of F (500mg/m2), E (100mg/m2) and C (500 mg/m²) q 21d (D-FEC), ± 4 cycles Bev (15mg/kg) (Bev+D-FEC). We present the DFS and OS results, analysed by intention-to-treat. pCR is defined by report review; analysis by central pathology review will be available at the time of presentation. Results: Between May’09 and Jan’13, we randomised 800 pts; 401 to D-FEC and 399 to Bev+D-FEC. Median follow-up was 3.4 yrs (IQR 2.5–4.4). 131 deaths and 183 DFS events have occurred. Both OS and DFS were similar across treatments (3-yr OS: Bev+D-FEC 85%, D-FEC 87%; hazard ratio (HR) 0.80 (95%CI 0.57-1.12) p = 0.19. 3-yr DFS: Bev+D-FEC 77%, D-FEC 80%; HR 0.86 (95%CI 0.64-1.14) p = 0.29). pCR was associated with improved OS in D-FEC pts (3-yr OS: pCR 96%, non-pCR 84%; log-rank p = 0.01) but not with Bev+D-FEC (3-yr OS: pCR 87%, non-pCR 83%; log-rank p = 0.71). Similarly pCR predicted for improved DFS with D-FEC (3-yr DFS: pCR 97%, non-pCR 76%; log-rank p = 0.0006), but not with Bev+D-FEC (3-yr DFS: pCR 84%, non-pCR 74%; log-rank p = 0.19). There was borderline heterogeneity in the effect of the addition of Bev between pCR and non-pCR groups in terms of OS (p = 0.07), and significant heterogeneity in terms of DFS (p = 0.02). Conclusions: Although Bev+D-FEC produced significantly higher pCR rates when added to chemotherapy in the ARTemis trial, OS and DFS were not improved. Moreover pCR achieved by Bev+D-FEC does not appear to be associated with the improved OS and DFS which is seen with pCR achieved by D-FEC. This data suggests that micro-metastatic breast cancer may be angiogenesis-independent and hence not altered by neoadjuvant Bev treatment. Clinical trial information: ISRCTN 68502941.
The Obliteration of Noncritical Size Bone Defects With Bone Dust or Bone Replacement Material (Bioactive Glass S53P4) (2019)

Hypothesis: Bone dust (BD) harvested during operation may be suitable as an autologous obliteration material for noncritical size defects. Bioactive glass (BA) can be an alternative. Background: To treat noncritical size defects, BD and BA are commonly used for obliteration techniques. However, the optimal harvesting method and parameters for BD have not been examined. In this study, we analyzed the osseoregenerative potential of both materials. Methods: Thirteen female merino sheep (7-yr old) underwent surgery on the frontal calvaria. Three defects were inserted. The first defect was considered a reference and remained unfilled, the second defect was filled with BD from the calvaria bone, and the third defect was filled with BA S53P4. The animals were sacrificed after 3 weeks. To evaluate bone regeneration, we used digital volume tomography, bone density measurement, fluorochrome sequence labeling, and histological analysis. Results: All analyses showed quantitative and qualitative bone regeneration 3 weeks after operation. The control blank defect showed significantly less new bone growth than the BD-filled defect. Moreover, bone regeneration occurred from the surrounding bone and showed only a defect bridge in the BD-filled defect. The BA completely filled the defect and had the highest density although the same amount of new mineralized bone generated as in the reference. Conclusion: BD and BA seemed to be suitable bone replacement materials for obliteration techniques because they completely filled the defects. Thus, BD harvested under standardized conditions provided a higher level of osteoreparation potential for the generation of woven bone and establishment of defect bridges.
RETRACTED ARTICLE: Intensification of resveratrol cytotoxicity, pro-apoptosis, oxidant potentials in human colorectal carcinoma HCT-116 cells using zein nanoparticles (2022)

Resveratrol (RSV), a non-flavonoid stilbene polyphenol, possesses anti-carcinogenic activities against all the major stages of cancer. Zein nanoparticles (ZN NPs) have been utilized successfully in delivery of variant therapeuticals by virtue of their histocompatible nature. The goal of this work was to comparatively explore the antiproliferative, pro-apoptotic and oxidative stress potentials of RSV-ZN NPs versus RSV against human colorectal carcinoma HCT-116 cells. ZN-RSV NPs were developed and assayed for particle size analysis and RSV diffusion. The selected formula obtained 137.6 ± 8.3 nm as mean particle size, 29.4 ± 1.8 mV zeta potential, 92.3 ± 3.6% encapsulation efficiency. IC<sub>50</sub> of the selected formula was significantly lower against HCT-116 cells versus Caco-2 cells. Also, significantly enhanced cellular uptake was generated from RSV-ZN NPs versus free RSV. Enhanced apoptosis was concluded due to increased percentage cells in G2-M and pre-G1 phases. The pro-apoptotic potential was explained by caspase-3 and cleaved caspase-3 increased mRNA expression in addition to NF-κB and miRNA125b decreased expression. Biochemically, ZN-RSV NPs induced oxidative stress as demonstrated by enhanced reactive oxygen species (ROS) generation and endothelial nitric oxide synthase (eNOS) isoenzyme increased levels. Conclusively, ZN-RSV NPs obtained cell cycle inhibition supported with augmented cytotoxicity, uptake and oxidative stress markers levels in HCT-116 tumor cells in comparison with free RSV. These results indicated intensified chemopreventive profile of RSV due to effective delivery utilizing ZN nano-dispersion against colorectal carcinoma HCT-116 cells.
A Reporter Screen in a Human Haploid Cell Line Identifies CYLD as a Constitutive Inhibitor of NF-κB (2013)

The development of forward genetic screens in human haploid cells has the potential to transform our understanding of the genetic basis of cellular processes unique to man. So far, this approach has been limited mostly to the identification of genes that mediate cell death in response to a lethal agent, likely due to the ease with which this phenotype can be observed. Here, we perform the first reporter screen in the near-haploid KBM7 cell line to identify constitutive inhibitors of NF-κB. CYLD was the only currently known negative regulator of NF-κB to be identified, thus uniquely distinguishing this gene. Also identified were three genes with no previous known connection to NF-κB. Our results demonstrate that reporter screens in haploid human cells can be applied to investigate the many complex signaling pathways that converge upon transcription factors.
Total Synthesis of d,l-Saxitoxin (1980)

HETEROCYCLCS.V o l 14.No 10, 1 9 8 0 preferentially from the opposite side of the hydroxymethyl group resulting in the desired stereochemistry at the C-4 and C-5 positions.An alternative possibility was the acid-catalyzed cyclization of the urea 1.Assuming that rapid protonation- deprotonation would be followed by slow cyclization, the desired stereochemistry at the C-4 and C-5 positions might be expected.A possible disconnection of the urea 3 is shown in Scheme 3. In the first retrosynthetic step in this scheme, three carbon-nitrogen bonds and one vinylogous carbon-nitrogen bond were disconnected.Thus, we hoped that the urea 1 could be Scheme 3 constructed from four indicated fragments.One of the encouraging factors in this disconnection was that the necessary enamine 2 could be synthesized by adapting 4 the Eschenmoser procedure .The feasibility of the retrosynthesis described above was first tested in the C-12 deoxo series, simply because of the availability of the starting material.Thus, 2-pyrrolidinone (z) was converted to the vinylogous urethane 13 by using Eschenmoser's procedure except for step 3, which is a straightforward cleavage reaction of a 8-keto, Om-imino ester system under basic conditions.Treatment of the vinylogous urethane -13 with isocyanic acid in the presence of acetaldehyde in ether at room temperature yielded a product in excellent yield.This cyclization
Supplementary Figure 8 from Therapeutic and Prophylactic Antitumor Activity of an Oral Inhibitor of Fucosylation in Spontaneous Mammary Cancers (2023)

&lt;p&gt;Mean {plus minus} SEM of peripheral cytokines detected in terminal sera collected from untreated (shaded) and 2FF-treated (unshaded) TgMMTV-neu mice. N=6 to 8 per group, *p&lt;0.05.&lt;/p&gt;
Data From a One-Stop-Shop Comprehensive Cancer Screening Center (2023)

We present a proof of concept study for a one-stop-shop approach to cancer screening in a multidisciplinary outpatient clinic. We successfully detected cancers at an early stage, which has the potential to reduce morbidity and mortality as well as offer substantial cost savings.[Media: see text].
Quantification of Specific Immunological Reactions by Atomic Force Microscopy (1997)

The aim of this work is to demonstrate the ability of atomic force microscopy (AFM) to detect and to quantify specific immunological reactions between antibodies and antigens, with a view to creating a very sensitive biosensor. A monolayer of antiferritin antibodies was adsorbed onto alkyl silane modified silicon oxide substrates, which were characterized by X-ray photoelectron spectroscopy (XPS) and contact angle measurements. The sensitivity limit for antibody detection was quantified by radioimmunoassay (RIA) and compared to that obtained by enzyme linked immuno sorbent assay (ELISA) and by AFM after antibody binding with colloidal gold labeled conjugates. In this latter case, substrate modification after reaction was checked by measuring the surface roughness (Rrms) variations. AFM was found to be more sensitive than RIA, with a detection limit of 0.3 × 10-3 ng of antibodies per mm2. Then, the biosensor performance was investigated using ferritin solutions of various concentrations: the antibody/antigen reaction was quantified by directly detecting the antigen and measuring surface roughness modifications. Results were compared to sandwich immunoassay techniques. Up to now, AFM has detected a minimum ferritin concentration of 0.06 μg/mL.
ChemInform Abstract: Novel One‐Pot Synthetic Method for Propargyl Alcohol Derivatives from Allyl Alcohol Derivatives. (2015)

Abstract Bromination of allyl alcohol derivatives [e.g. (I)] gives 1,2‐dibromoalkanes, which undergo double trans‐HBr elimination, promoted by Bu 4 NOH, to give the propargyl alcohols [e.g. (II)].
Chemical Chaperones Improve Protein Secretion and Rescue Mutant Factor VIII in Mice with Hemophilia A (2012)

Inefficient intracellular protein trafficking is a critical issue in the pathogenesis of a variety of diseases and in recombinant protein production. Here we investigated the trafficking of factor VIII (FVIII), which is affected in the coagulation disorder hemophilia A. We hypothesized that chemical chaperones may be useful to enhance folding and processing of FVIII in recombinant protein production, and as a therapeutic approach in patients with impaired FVIII secretion. A tagged B-domain-deleted version of human FVIII was expressed in cultured Chinese Hamster Ovary cells to mimic the industrial production of this important protein. Of several chemical chaperones tested, the addition of betaine resulted in increased secretion of FVIII, by increasing solubility of intracellular FVIII aggregates and improving transport from endoplasmic reticulum to Golgi. Similar results were obtained in experiments monitoring recombinant full-length FVIII. Oral betaine administration also increased FVIII and factor IX (FIX) plasma levels in FVIII or FIX knockout mice following gene transfer. Moreover, in vitro and in vivo applications of betaine were also able to rescue a trafficking-defective FVIII mutant (FVIIIQ305P). We conclude that chemical chaperones such as betaine might represent a useful treatment concept for hemophilia and other diseases caused by deficient intracellular protein trafficking.
Tailoring and cancelling dispersion of slow or stopped and subwavelength surface-plasmonodielectric-polaritonic light (2009)

One fundamental aspect of photonic technology has always been the quest for the perfect light-guiding system, which would exhibit, over a large frequency bandwidth, subwavelength modes of controllable (with special interest lately on small [1]) group velocity and small attenuation, both devoid of frequency dispersion [2]. If this were possible, a temporally and spatially tiny wavepacket would basically propagate without changing shape but only with slowly uniformly decreasing size. Such a system is yet not known to exist in nature, as none of the existing material platforms can achieve simultaneously all of the above attributes, but at most only a subset. All-dielectric structures [3] cannot support highly-subwavelength light propagation, which can be attained by exploiting (bulk or surface) polaritons in plasmonic [4-14] or other resonant-material (e.g. atomic, excitonic, phononic [15, 16]) waveguiding structures, which typically suffer though from high absorption losses. The one problem, however, that is commonly shared among all existing photonic systems is modal dispersion. In particular, for slow- [17-25] and stopped- [26-28] light systems, dispersion is the major reason there is a limitation on their achievable so-called 'bandwidth-delay product' [29-34]. This fact has thus motivated the recent invention of a few advanced dispersion-cancellation schemes, which make use of coupled geometric [35] or gain-material [36] resonances or a fine balance of dispersion with nonlinearities [37]. It was also pointed out recently [38] that layered axially-uniform plasmonic-dielectric-hybrid waveguiding systems can guide broadband slow and subwavelength light, but the proposed systems were still dispersion-limited. In this Article, we show that such multilayered Surface-PlasmonoDielectric-Polaritonic (SPDP) systems allow for a new physical mechanism, which enables their inherently-single-polarization surface-polaritonic modes to additionally have - for small positive, negative or zero group-velocity - the dispersion coefficients of simultaneously both the group velocity and the attenuation systematically cancelled to unusually high orders, thus leading to the first linear passive system in nature, known to us, that essentially is dispersionless and breaks the 'bandwidth-delay product' limitation. By arguing [38] that, in the absence of disorder, attenuation may also, in principle, be reducible by cooling, these material systems approach the ideal slow-light-guiding system. Furthermore, they can also be tailored to invent a variety of novel intricate dispersion relations with multiple points of zero group velocity. The applications of this class of guiding systems in the technological realm of nanophotonics could be substantial.
Antenne millimétrique F inversée (IFA) en technologie SOI (2007)

National audience
Reflectarray element using interdigital gap loading structure (2011)

A novel reflectarray element using an interdigital gap loading structure is proposed. A wide reflection phase range of more than 1000° is obtained, which can support a sufficient phase range for a large scattering angle (up to 60°) reflectarray. Furthermore, this element has a feature of equal element size because the reflection phase is adjusted by controlling the finger length of the interdigital gap. Thus, abrupt geometry variations for consecutive cells in the traditional reflectarray can be avoided. A Ku-band reflectarray has been fabricated and measured results show good agreement with simulation.
Resolution Improvement through Sparse Image Reconstruction Techniques for Dark Field Subsurface Microscopy of Integrated Circuits (2014)

Abstract Sparse image reconstruction techniques have been used to recover high frequency information lost during the acquisition process in different imaging domains, such as ultrasound, synthetic aperture radar, optical microscopy, and astronomical and microscopic imaging. In this work, a signal processing framework is proposed to estimate the Point Spread Function (PSF) of the dark-field subsurface microscopy system from observation data. This PSF is incorporated into an image reconstruction framework, which can be formulated with two different image reconstruction techniques, regularized image reconstruction and dictionary-based image reconstruction. It is observed that both techniques provide at least 12% resolution improvement; lines with 224 nm spacing were localized after resolution improvement while lines with 252 nm spacing are at the limit of localization in experimental data. However, dictionary-based image reconstruction provides higher edge resolution and maintains the homogeneity of the intensity within the structures.
Performance of an Intra- and Inter-Cell Interference Mitigation Algorithm in HSDPA System (2008)

Linear equalizer is known to effectively suppress intra-cell interference caused by the multi path propagation in high speed downlink packet access (HSDPA) system. Equalizer algorithms are commonly based on linear minimum mean square error (LMMSE) estimators, which can also take into account the colored interference from other cells. However, several receive antennas are required to efficiently cancel inter-cell interference. On the other hand, non-linear methods are attractive if only one receive antenna is present. However, these algorithms tend to require several auxliary parameters to be known. In this paper, we study a two stage single antenna receiver, combining non-linear and linear processing in HSDPA system. The first stage uses blind interference cancellation (BIC) algorithm to cancel the dominant part of the other cell interference and the second stage uses the LMMSE equalizer to suppress intra-cell interference. The performance of the two stage receiver is compared against conventional LMMSE equalizer. The results show that the studied non-linear algorithm achieves improved performance especially on the cell edge.
Analysis of the efficiency of blanket cutting methods in the production of small rolled rods in rods (2022)

The purpose of the work is to analyze the effectiveness of methods of cutting blanks on continuous blanking machines (CBMs) in the production of graded rolled metal in rods. Practically 100% of the orders for small-grade rolled products in rods are measured products, while the actual output of measured products from the rolling mill is 95-98%, and the rest is non-measured products. At the final stage of rolled production, metal losses also occur due to excessive technological cutting during the cutting of rolled products. There are economic losses associated with the sale of bundles of irregular rods at a lower cost. The analysis of numerous studies and scientific publications made it possible to formulate the task of inventing such cutting strategies and algorithms that ensure the minimization of finished rolled products due to the coordinated management of continuous blanking mills (BZS) and continuous small grade mills (BDS). It is shown that at the final stage of the production of commercial products on continuous rolling mills, metal losses occur due to non-dimensional residues and excessive trimming, which arises, on the one hand, as a result of the fact that the length of the workpiece, which is fed to the entrance of the rolling mill, is not a multiple of the finished dimensional profile , and on the other - due to the peculiarities of the equipment of the rolling mills that implement cutting operations. The paper shows that the choice of methods for cutting rolled metal is a multi-criteria task. The analysis of the marginal deviations of the geometric dimensions of the blanks and small rolled products was carried out. On the basis of the calculations, it is shown that the simultaneous provision of the economic criterion and the criterion of the maximum yield of dimensional rolled bars is possible only in the production of reinforcing profiles larger than No. 14, and in the production of smaller profiles, the criterion of the maximum filling of the refrigerator should be used. It is shown that in the production of fine-grade profiles, the most effective method is the method of cutting rolled steel with cutting off the non-dimensional part. The obtained data can be used to build cutting plans in the production of commodity rolled metal.