gebhart/patrepeval huggingface dataset:
28 GHz Distributed-MIMO Comprehensive Antenna Calibration for 5G Indoor Spatial Division Multiplex (2021)

This paper describes the experimental verifications of a 28 GHz multi-user distributed multiple-input multiple-output (MIMO) using newly developed comprehensive calibration without additional transceiver path for 5G indoor multiple access applications. The eight distributed active antennas are connected to a digital and mixed signal processing unit. The proposed calibration method for the distributed MIMO enhances the number of simultaneous users and system throughput. We demonstrate the zero-forcing spatial multiplex using up-link to down-link channel reciprocity for two, four, and six user equipment in actual office over the air circumstances. The distributed MIMO exhibits two times greater spatial multiplexing efficiency than a conventional collocated Massive MIMO and achieves the system throughput of 2.1 Gbps per 100 MHz summing simultaneous connected six users.
Be in the Driver's Seat! [President's Corner (2010)

Physicists including Newton, Einstein, or Max Plank have left their unique marks that will forever be tied to their names. Electronics also has leaders, and this magazine chronicled many of their contributions. But unlike the quantum leaps in the sciences, progress in electronics follows a very predictable and steady path enabled by the collective contributions from a large community of engineers.
Abstract 2101: Enzymatic methyl-seq: Cytosine methylation detection using picograms of DNA (2021)

Cytosine methylation (5mC) is an important regulator of gene expression. Bisulfite sequencing is most commonly used to study 5mCs but it is frequently associated with DNA damage and fragmentation. This can prove problematic when using low amounts of DNA as the damage results in uneven genome coverage as well as biased sequencing data. Here we show data generated using NEBNext® Enzymatic Methyl-Seq (EM-Seq™), an enzymatic alternative to bisulfite conversion. The method has been optimized for low input DNAs ranging from 10 ng to 100 pg. NA12878 DNA was used to demonstrate that the modifications to the protocol permitted accurate representation of global CpG, CHG and CHH methylation. These libraries also displayed similar basic metrics to standard input EM-seq libraries. The GC bias plot was even and there was high CpG coverage with strong correlation between replicates. In addition, the possibility of introducing unique molecular identifiers into this system would be useful for many researchers who use DNA originating from single cells, plasma (cfDNA) and formalin fixed paraffin embedded (FFPE) sections. This low input method is robust and reproducible and gives researchers a new tool to tackle studies where DNA has traditionally been limiting. Citation Format: Louise Williams, V. K. Chaithanya Ponnaluri, Vaishnavi Panchapakesa, Romualdas Vaisvila, Matthew A. Campbell, Bradley W. Langhorst, Eileen T. Dimalanta, Theodore B. Davis. Enzymatic methyl-seq: Cytosine methylation detection using picograms of DNA [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr 2101.
Total synthesis of erythromycins. 3. Stereoselective routes to intermediates corresponding to C(1) to C(9) and C(10) to C(13) fragments of erythronolide B (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal synthesis of erythromycins. 3. Stereoselective routes to intermediates corresponding to C(1) to C(9) and C(10) to C(13) fragments of erythronolide BE. J. Corey, Eugene J. Trybulski, Lawrence S. Melvin Jr., K. C. Nicolaou, John A. Secrist, Robert Lett, Peter W. Sheldrake, J. R. Falck, Daniel J. Brunelle, and Cite this: J. Am. Chem. Soc. 1978, 100, 14, 4618–4620Publication Date (Print):July 1, 1978Publication History Published online1 May 2002Published inissue 1 July 1978https://pubs.acs.org/doi/10.1021/ja00482a062https://doi.org/10.1021/ja00482a062research-articleACS PublicationsRequest reuse permissionsArticle Views2578Altmetric-Citations112LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Self-phase modulation at visible wavelengths in nonlinear ZnO channel waveguides (2010)

We report the observation of nonlinear optical effects in the visible spectrum using ZnO channel waveguides. We demonstrate sixfold spectral broadening and a 2π phase shift due to self-phase modulation in ZnO channel waveguides using femtosecond optical pulses with a center wavelength of 840 nm. We measured a value for the nonlinear parameter γ of 13.9±3.0 W−1 m−1, which is more than 1300 times that of a highly nonlinear fiber. The calculated intensity-dependent refractive index is found to be consistent with previously reported values of bulk single-crystal ZnO.
Genome-wide expression profiling of maize in response to individual and combined water and nitrogen stresses (2013)

Overall, this study suggests that the molecular signature of a specific combination of stresses on the transcriptome might be as unique as the impact of individual stresses, and hence underlines the difficulty to extrapolate conclusions obtained from the study of individual stress responses to more complex settings.
A multi-filter system for speech enhancement under lowsignal-to-noise ratios (2009)

In this paper, the problem of deteriorating performance of speechrecognition under very low signal-to-noise ratios (SNR) isconsidered. In particular, for a given pre-trained speech recognizerand for a finite set of speech commands, we show that popular noisereduction methods have a mixed performance in speech recognitionaccuracy under very low SNR. Although most noise reduction methodsare attempting to reduce speech distortion or to increase noisesuppression, it does not necessarily improve speech recognitionaccuracy very much due to the complexity of the recognizer. Wepropose a new hybrid algorithm to optimize on the speech recognitionaccuracy directly by mixing different noise reduction methodstogether. We show that this method can indeed improve the accuracysignificantly.
Modeling mosquito-borne and sexual transmission of Zika virus in an enzootic host, the African green monkey (2020)

Mosquito-borne and sexual transmission of Zika virus (ZIKV), a TORCH pathogen, recently initiated a series of large epidemics throughout the Tropics. Animal models are necessary to determine transmission risk and study pathogenesis, as well screen antivirals and vaccine candidates. In this study, we modeled mosquito and sexual transmission of ZIKV in the African green monkey (AGM). Following subcutaneous, intravaginal or intrarectal inoculation of AGMs with ZIKV, we determined the transmission potential and infection dynamics of the virus. AGMs inoculated by all three transmission routes exhibited viremia and viral shedding followed by strong virus neutralizing antibody responses, in the absence of clinical illness. All four of the subcutaneously inoculated AGMs became infected (mean peak viremia: 2.9 log10 PFU/mL, mean duration: 4.3 days) and vRNA was detected in their oral swabs, with infectious virus being detected in a subset of these specimens. Although all four of the intravaginally inoculated AGMs developed virus neutralizing antibody responses, only three had detectable viremia (mean peak viremia: 4.0 log10 PFU/mL, mean duration: 3.0 days). These three AGMs also had vRNA and infectious virus detected in both oral and vaginal swabs. Two of the four intrarectally inoculated AGMs became infected (mean peak viremia: 3.8 log10 PFU/mL, mean duration: 3.5 days). vRNA was detected in oral swabs collected from both of these infected AGMs, and infectious virus was detected in an oral swab from one of these AGMs. Notably, vRNA and infectious virus were detected in vaginal swabs collected from the infected female AGM (peak viral load: 7.5 log10 copies/mL, peak titer: 3.8 log10 PFU/mL, range of detection: 5-21 days post infection). Abnormal clinical chemistry and hematology results were detected and acute lymphadenopathy was observed in some AGMs. Infection dynamics in all three AGM ZIKV models are similar to those reported in the majority of human ZIKV infections. Our results indicate that the AGM can be used as a surrogate to model mosquito or sexual ZIKV transmission and infection. Furthermore, our results suggest that AGMs are likely involved in the enzootic maintenance and amplification cycle of ZIKV.
Catalysis of ACAT may be completed within the plane of the membrane: a working hypothesis (2001)

Two ACAT sharing protein sequence homology near their C termini have been identified. Both proteins may span the endoplasmic reticulum (ER) membrane several times. There is good evidence implicating the role of ACAT1 in macrophage foam cell formation, and ACAT2 in intestinal cholesterol absorption. On the other hand, the functional roles of ACAT1 and ACAT2 in the VLDL or chylomicron assembly process are less clear. It is possible that both enzymes are able to form lipid droplets (which are present in the cytoplasm), and participate in lipoprotein assembly (which occurs in the ER lumen). To link the site of ACAT catalysis with its function, we propose that part of the ACAT catalytic site may reside within the lipid bilayer, allowing catalysis to be completed within the plane of the membrane. Cholesteryl esters (CE) produced in situ may burst into cytoplasmic lipid droplets, carrying phospholipid monolayers as their outer coats. In cells engaged in lipoprotein assembly and secretion, CE in the bilayer may be recognized by the specific protein microsomal triacylglycerol transfer protein (MTP), reaching out from the lumenal side of the membrane. MTP then lipidates the growing apolipoprotein B (apoB) chain with CE and TG during the early stages of apoB lipoprotein assembly.
Protective Effect of Human Heat Shock Protein 60 Suggested by Its Association with Decreased Seropositivity to Pathogens (2007)

The presence of heat shock protein 60 (Hsp60) in human plasma has been linked with cardiovascular disease (CVD). In this study, the examination of the relationship between Hsp60 in plasma and seropositivity for three microbial agents, which are thought to be risk factors for CVD, surprisingly revealed a negative association between Hsp60 and seropositivity, suggesting a protective effect of this circulating stress protein.
ChemInform Abstract: SYNTH. VON 1,6‐DIOXA‐6ALPHA‐THIAPENTALENEN, SCHWEFEL‐SAUERSTOFF‐KUPPLUNG DURCH THALLIUM(III)‐TRIFLUORACETAT (1973)

Abstract Die Pyran‐thione (I) reagieren in Acetonitril bei Raumtemperatur mit Thallium(III)‐trifluoracetat (II) zu den Pyryliumsalzen (III), die ohne Isolierung mit Wasser direkt über die Zwischenstufen (IV) zu den 1,6‐Dioxa‐thiapentalenen (V) umgesetzt werden.
Nanometer Scale Gap Made by Conventional Microscale Fabrication:  Step Junction (2004)

This paper describes a simple way to build a nanometer scale gap, using conventional microscale fabrication techniques such as optical lithography, electron-beam evaporation, and lift-off. Using electron-beam evaporation and lift-off of a metal line, it is possible to transfer the positive slope at the developed pattern edge in positive photoresist to a corresponding negative (undercut) slope in the resulting edge of the metal line. This negative slope on the metal pattern edge is subsequently used as a shadow for a second, thinner metal layer. Using this shadow, we demonstrate that a nanometer scale gap, denoted as a step junction, can be built between the two metal layers. The current−voltage characteristics of the resulting gaps have been characterized and the gaps have been imaged using scanning electron microscopy. To illustrate the application of a step junction structure as a nanoscale gap electrode, conductive bridges consisting of organic monolayers and nanoscale gold clusters were formed between the two electrodes. The observation of the clusters in scanning electron microscope (SEM) images and enhanced conductivity in the devices indicates that the step junction structure provides a means to realize efficient electrical contacts to nanoscale conductive elements.
Viral vector‐based gene therapies in the clinic (2021)

Gene therapies are currently one of the most investigated therapeutic modalities in both the preclinical and clinical settings and have shown promise in treating a diverse spectrum of diseases. Gene therapies aim at introducing a gene material in target cells and represent a promising approach to cure diseases that were thought to be incurable by conventional modalities. In many cases, a gene therapy requires a vector to deliver gene therapeutics into target cells; viral vectors are among the most widely studied vectors owing to their distinguished advantages such as outstanding transduction efficiency. With decades of development, viral vector-based gene therapies have achieved promising clinical outcomes with many products approved for treating a range of diseases including cancer, infectious diseases and monogenic diseases. In addition, a number of active clinical trials are underway to further expand their therapeutic potential. In this review, we highlight the diversity of viral vectors, review approved products, and discuss the current clinical landscape of in vivo viral vector-based gene therapies. We have reviewed 13 approved products and their clinical applications. We have also analyzed more than 200 active trials based on various viral vectors and discussed their respective therapeutic applications. Moreover, we provide a critical analysis of the major translational challenges for in vivo viral vector-based gene therapies and discuss possible strategies to address the same.
Fate of Kepone and Mirex in a Model Aquatic Environment: Sediment, Fish, and Diet (1981)

Laboratory studies of freshwater sediment and a daphnid–bluegill (Daphnia magna–Lepomis macrochirus) food chain indicated that the organochlorine insecticides Kepone and mirex resist microbial degradation, accumulate and resist metabolism in fish, and move through a food chain. We found no direct evidence of degradation of either compound after 56 d of incubation in freshwater sediments under aerobic or anaerobic conditions. Furthermore, we found no metabolism or co-metabolism of 14 C-labeled Kepone in sediments that had long-term preexposure to Kepone and by-products nor did we detect a selective process occurring in the sediments that changed the capacity of the autochthonous microbiota to metabolize Kepone. After 28 d of exposure to 14 C-labeled Kepone or mirex in water and natural food, bluegills accumulated Kepone and mirex equal to 10 606 and 12 274 times the respective exposure concentrations. Elimination patterns were dissimilar: mirex tended to persist in fish tissue but Kepone did not. Neither Kepone nor mirex was metabolized by bluegills. Retention of mirex introduced into bluegills by daphnids was about 3 times greater than that of Kepone. Accumulation of Kepone and mirex by bluegills was about half that of DDT.Key words: Kepone, mirex, degradation, freshwater sediment, accumulation, elimination, bluegills, daphnids, residue dynamics, food chain, accumulation index
Compressive Millimeter Wave and X-Ray Tomography (2014)

Compressive tomography consists of estimation of high dimensional objects from measurements distributed over lower dimensions. Examples include reconstruction of 3D spectral data cubes from 2D focal planes and reconstruction of 3D volumes from 2D x-ray projections or holograms. Compressive tomographic estimation is improved if projections are structured to randomize the sampling phase space. To illustrate this principle, we show that structured x-ray illumination enables improvements in reconstructed image quality for compressed measurements relative to full Radon sampling and that structured millimeter wave illumination improves estimation of 3D surfaces.
EU FP7 INFSO-ICT-317669 METIS, D2.2 Novel radio link concepts and state of the art analysis (2013)

This document provides a detailed overview of the Radio Link concepts being developed in METIS as well as a detailed analysis of the related state of the art. For each of the research topics identified for the radio link research covering flexible air interface, new waveforms,modulation and coding techniques as well as multiple access, medium access control and enablers for radio resource management, a detailed description of the aspects to be investigated will be given, going beyond the limits imposed by the systems operated today and their planned evolutions. The state of the art analysis, which is conducted for each of the research topics separately, covers current standards, their future evolutions as well as latest academic research. Elaborating on how the approaches followed in the radio link research may advance this state of the art carves a promising track towards innovative solutions addressing the challenges of future wireless communication.
Effectiveness of dynamic cognitive intervention in rehabilitation of clients with schizophrenia (2001)

The successful outcome points to the importance of including long-term cognitive intervention in rehabilitation of schizophrenic clients. This work suggests that the classic view of schizophrenia as a progressive irreversible decline that cannot be altered may be wrong.
Lexical Substitution for the Medical Domain (2014)

In this paper we examine the lexical substitution task for the medical domain. We adapt the current best system from the open domain, which trains a single classifier for all instances using delexicalized features. We show significant improvements over a strong baseline coming from a distributional thesaurus (DT). Whereas in the open domain system, features derived from WordNet show only slight improvements, we show that its counterpart for the medical domain (UMLS) shows a significant additional benefit when used for feature generation.
Smart Anesthesia Manager$^{\rm TM}$ (SAM)—A Real-time Decision Support System for Anesthesia Care during Surgery (2012)

Anesthesia information management systems (AIMS) are being increasingly used in the operating room to document anesthesia care. We developed a system, Smart Anesthesia Manager™ (SAM) that works in conjunction with an AIMS to provide clinical and billing decision support. SAM interrogates AIMS database in near real time, detects issues related to clinical care, billing and compliance, and material waste. Issues and the steps for their resolution are brought to the attention of the anesthesia provider in real time through "pop-up" messages overlaid on top of AIMS screens or text pages. SAM improved compliance to antibiotic initial dose and redose to 99.3 ± 0.7% and 83.9 ± 3.4% from 88.5 ± 1.4% and 62.5 ± 1.6%, respectively. Beta-blocker protocol compliance increased to 94.6 ± 3.5% from 60.5 ± 8.6%. Inadvertent gaps (>15 min) in blood pressure monitoring were reduced to 34 ± 30 min/1000 cases from 192 ± 58 min/1000 cases. Additional billing charge capture of invasive lines procedures worth $144,732 per year and 1,200 compliant records were achieved with SAM. SAM was also able to reduce wastage of inhalation anesthetic agents worth $120,168 per year.
Ex Vivo Expansion of Human Hematopoietic Stem Cells by Garcinol, a Potent Inhibitor of Histone Acetyltransferase (2011)

Our findings identify Garcinol as the first natural product acting on HSCs/PCs and suggest the inhibition of HAT to be an alternative approach for manipulating HSCs/PCs.
Two-dimensional ordering of viologen polymers fixed on charged surface of bilayer membranes: A peculiar odd-even effect on redox potential and absorption spectrum (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTwo-dimensional ordering of viologen polymers fixed on charged surface of bilayer membranes: A peculiar odd-even effect on redox potential and absorption spectrumMasatsugu Shimomura, Koji Utsugi, Jun Horikoshi, Kenji Okuyama, Osamu Hatozaki, and Noboru OyamaCite this: Langmuir 1991, 7, 4, 760–765Publication Date (Print):April 1, 1991Publication History Published online1 May 2002Published inissue 1 April 1991https://pubs.acs.org/doi/10.1021/la00052a026https://doi.org/10.1021/la00052a026research-articleACS PublicationsRequest reuse permissionsArticle Views339Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
2A2-K10 Microfluidic System Using Ultrasonic Vibration : Evaluation as Mixer (2009)

This paper describes design, fabrication, and evaluation of a dual-purpose element for micro total analysis system (μTAS). The element approached two functions for μTAS applications. One is a micropump which transports the liquid and the other is a micromixer which stirs the liquid. It is possible to downsize a system with densely-integrated system by developing a dual-purpose element. These functions are obtained by ultrasonic vibration. The micropump uses a traveling vibration on an ultrasonic vibrator and the micromixer uses a standing vibration of it. The ultrasonic vibrator is composed of a piezo element (piezoelectric zirconate titanate, PZT) disk (φ20mm×0.5mm), a brass disk (φ20mm×2mm) and a phosphor bronze disk (φ30mm×0.1mm). The liquid chamber is φ28mm×1mm. The mixing experiment confirms the effectiveness of the proposed mixing principle.