gebhart/patrepeval huggingface dataset:
Oscillatory Neural Networks Using VO2 Based Phase Encoded Logic (2021)

Nano-oscillators based on phase-transition materials are being explored for the implementation of different non-conventional computing paradigms. In particular, vanadium dioxide (VO<sub>2</sub>) devices are used to design autonomous non-linear oscillators from which oscillatory neural networks (ONNs) can be developed. In this work, we propose a new architecture for ONNs in which sub-harmonic injection locking (SHIL) is exploited to ensure that the phase information encoded in each neuron can only take two values. In this sense, the implementation of ONNs from neurons that inherently encode information with two-phase values has advantages in terms of robustness and tolerance to variability present in VO<sub>2</sub> devices. Unlike conventional interconnection schemes, in which the sign of the weights is coded in the value of the resistances, in our proposal the negative (positive) weights are coded using static inverting (non-inverting) logic at the output of the oscillator. The operation of the proposed architecture is shown for pattern recognition applications.
Destabilization of light NREM sleep by thalamic PLCβ4 deletion impairs sleep-dependent memory consolidation (2020)

Sleep abnormality often accompanies the impairment of cognitive function. Both rapid eye movement (REM) and non-REM (NREM) sleep have associated with improved memory performance. However, the role of composition in NREM sleep, consisting of light and deep NREM, for memory formation is not fully understood. We investigated how the dynamics of NREM sleep states influence memory consolidation. Thalamocortical (TC) neuron-specific phospholipase C β4 (PLCβ4) knockout (KO) increased the total duration of NREM sleep, consisting of destabilized light NREM and stabilized deep NREM. Surprisingly, the longer NREM sleep did not improve memory consolidation but rather impaired it in TC-specific PLCβ4 KO mice. Memory function was positively correlated with the stability of light NREM and spindle activity occurring in maintained light NREM period. Our study suggests that a single molecule, PLCβ4, in TC neurons is critical for tuning the NREM sleep states and thus affects sleep-dependent memory formation.
Gelation of plasmonic metal oxide nanocrystals by polymer-induced depletion attractions (2018)

Gelation of colloidal nanocrystals emerged as a strategy to preserve inherent nanoscale properties in multiscale architectures. However, available gelation methods to directly form self-supported nanocrystal networks struggle to reliably control nanoscale optical phenomena such as photoluminescence and localized surface plasmon resonance (LSPR) across nanocrystal systems due to processing variabilities. Here, we report on an alternative gelation method based on physical internanocrystal interactions: short-range depletion attractions balanced by long-range electrostatic repulsions. The latter are established by removing the native organic ligands that passivate tin-doped indium oxide (ITO) nanocrystals while the former are introduced by mixing with small PEG chains. As we incorporate increasing concentrations of PEG, we observe a reentrant phase behavior featuring two favorable gelation windows; the first arises from bridging effects while the second is attributed to depletion attractions according to phase behavior predicted by our unified theoretical model. Our assembled nanocrystals remain discrete within the gel network, based on X-ray scattering and high-resolution transmission electron microscopy. The infrared optical response of the gels is reflective of both the nanocrystal building blocks and the network architecture, being characteristic of ITO nanocrystals' LSPR with coupling interactions between neighboring nanocrystals.
Recent advances on topical antimicrobials for skin and soft tissue infections and their safety concerns (2017)

Antimicrobial resistance of disease-related microorganisms is considered a worldwide prevalent and serious issue which increases the failure of treatment outcomes and leads to high mortality. Considering that the increased resistance to systemic antimicrobial therapy often needs of the use of more toxic agents, topical antimicrobial therapy emerges as an attractive route for the treatment of infectious diseases. The topical antimicrobial therapy is based on the absorption of high drug doses in a readily accessible skin surface, resulting in a reduction of microbial proliferation at infected skin sites. Topical antimicrobials retain the following features: (a) they are able to escape the enzymatic degradation and rapid clearance in the gastrointestinal tract or the first-pass metabolism during oral administration; (b) alleviate the physical discomfort related to intravenous injection; (c) reduce possible adverse effects and drug interactions of systemic administrations; (d) increase patient compliance and convenience; and (e) reduce the treatment costs. Novel antimicrobials for topical application have been widely exploited to control the emergence of drug-resistant microorganisms. This review provides a description of antimicrobial resistance, common microorganisms causing skin and soft tissue infections, topical delivery route of antimicrobials, safety concerns of topical antimicrobials, recent advances, challenges and future prospective in topical antimicrobial development.
The Selectivity of Electrode Reactions in Semiconductor Electrodes (1989)

Electrode processes at illuminated semiconductor photoanodes were investigated by a rotating ring disk electrode with as a disk. The collection efficiency in a solution was found to be larger than the theoretical collection efficiency . When the light intensity was kept constant, the collection efficiency increased with lowering band bending and exceeded with the ring potential being −0.4V vs. SCE at . A large collection efficiency observed was ascribed to electrons and holes that can have different reaction pathways, in which cathodic reaction by electrons and anodic reaction by holes can take place independently and simultaneously without recombination. As a result, the disk current decreases because the hole flux is counterbalanced by the electron flux, but the oxidation product to be detected at the ring electrode remains constant. Consequently, the collection efficiency defined by the ratio of the ring current to the disk current can be much larger than . It is pointed out that the electron transfer near the flatband potential does not necessarily mean an electron‐hole recombination, which is believed to determine the current‐potential characteristics in the electrolyte‐semiconductor interface, as well as the metal‐semiconductor interface. On the basis of a model developed herein, the transfer coefficient for electrons was determined to be 0.88 for the electrode reaction of
Measurements of the wireless ad hoc array concept in a large building setting for public-safety communications (2010)

Here we report on measurements of the ad hoc array concept in an enclosed atrium/lobby area of a high-rise building in Denver, Colorado. A typical ad hoc network is limited to coverage area achieved by the useable coverage of single nodes; however, we seek to expand the radio frequency coverage by using two or more nodes as elements of an ad hoc array. Previous simulations and theoretical analysis suggest the benefits of the array concept; these measurements in a real-world environment demonstrate that the ad hoc array can provide meaningful gain, up to 10 dB with only four elements. The measurements also indicate a gain of 4 dB to 6 dB using only two elements.
Scalable Nanostructured Carbon Electrode Arrays for Enhanced Dopamine Detection (2018)

Dopamine is a neurotransmitter that modulates arousal and motivation in humans and animals. It plays a central role in the brain "reward" system. Its dysregulation is involved in several debilitating disorders such as addiction, depression, Parkinson's disease, and schizophrenia. Dopamine neurotransmission and its reuptake in extracellular space takes place with millisecond temporal and nanometer spatial resolution. Novel nanoscale electrodes are needed with superior sensitivity and improved spatial resolution to gain an improved understanding of dopamine dysregulation. We report on a scalable fabrication of dopamine neurochemical probes of a nanostructured glassy carbon that is smaller than any existing dopamine sensor and arrays of more than 6000 nanorod probes. We also report on the electrochemical dopamine sensing of the glassy carbon nanorod electrode. Compared with a carbon fiber, the nanostructured glassy carbon nanorods provide about 2× higher sensitivity per unit area for dopamine sensing and more than 5× higher signal per unit area at low concentration of dopamine, with comparable LOD and time response. These glassy carbon nanorods were fabricated by pyrolysis of a lithographically defined polymeric nanostructure with an industry standard semiconductor fabrication infrastructure. The scalable fabrication strategy offers the potential to integrate these nanoscale carbon rods with an integrated circuit control system and with other complementary metal oxide semiconductor (CMOS) compatible sensors.
Blue Light-Driven [4+2]-Cycloaddition: Diastereoselective Synthesis of Chromeno[4,3-b]quinoline and Chromeno[4,3-b][1,8]naphthyridine Scaffolds (2022)

A one-pot, metal-free, light-driven [4+2]-cycloaddition reaction is described by accessing a diverse collection of chromeno[4,3-<i>b</i>]quinoline and chromeno[4,3-<i>b</i>][1,8]naphthyridine scaffolds in a diastereoselective manner. This process delivered stereoisomers, which were challenging to produce by an inverse-demand Diels-Alder reaction. The tetracyclic products were provided in good yields, promoted by rose bengal and blue light in a single operation. The developed protocol proceeded efficiently without the need for expensive photosensitizers such as Ir or Ru complexes. The cascade is modular and step-economic, and the substrate scope is wide. Polycyclic architectures can be assembled from readily available aniline, aminoazine, indole, and salicylaldehyde derivatives.
Cryogenic etching of porous organosilicate low-k materials: Reduction of plasma induced damage (2015)

International audience
Interferometric surface monitoring of biological tissue to study inertially confined ablation (1994)

We present results from the application of laser interferometry to the study of short-pulsed laser ablation of biological tissue. The mechanical response of tissue to laser-induced stress is examined under subthreshold conditions to determine its role in initiating the ablation process. A theoretical model is developed to relate this surface displacement to the pressure within the tissue and the mechanical properties of the tissue. In the experiment, a 7.5 ns pulse of 355 nm light was used to irradiate bovine shank bone, human meniscus, and an aqueous dye solution. Interferometric monitoring of the tissue surface was used to determine its motion after laser irradiation. The surface movement of bone was qualitatively consistent with the theoretical predictions of the model. The movement of meniscus and an aqueous dye solution showed additional features that are consistent with the growth and collapse of cavitation bubbles.
From a Federated to an Integrated Architecture for Dependable Embedded Systems (2004)

TIME-TRIGGERED ARCHITECTURE (TTA) is an integrated architecture for the implementation of large distributed real-time control systems in high-dependability applications. The TTA realizes the positive aspects of integration such as: (i) significant reduction of the software cost by the strong support for composability, diagnosis, and the re-use of services; (ii) significant reduction of the hardware cost and of the wiring points (reliability improvement); (iii) architectural support of the implementation of fault tolerance; (iv) increased potential and flexibility of function integration while minimizing the negative impact of integration; (v) error propagation from one DAS to another DAS; (vi) blurring of responsibility during system integration; (vii) difficulties in diagnostics.
Nucleotide Excision Repair Inhibitors: Still a Long Way to Go (2013)

The last few decades have witnessed a new astounding trend emerge in cancer research. The new strategy materialized as a glimmer of hope to improve current standard cancer treatments that target DNA. These DNA-damaging agents induce lesions into the genome, which are aimed at preventing cancer cells from proliferating and invading the surrounding tissue. However, as was shown by many experiments, in response to that cancer cells mobilize DNA repair pathways that tend to remove the induced damage. As a consequence, they exhibit increased resistance towards what would otherwise be an efficacious treatment [1]. These findings have validated DNA repair enzymes as new molecular targets in the context of the battle against cancer [2]. Fortunately, the proof of the concept of targeting DNA repair as a cancer-therapeutic-strategy has been provided by several convincing studies, many of which are advancing through pre-clinical and clinical trials [3]. A particular example of a novel target in such pathways is the nucleotide excision repair (NER) mechanism, which correlates with the induced resistance to platinum treatments [4].
Mid-infrared supercontinuum generation in As_2S_3-silica “nano-spike” step-index waveguide (2013)

Efficient generation of a broad-band mid-infrared supercontinuum spectrum is reported in an arsenic trisulphide waveguide embedded in silica. A chalcogenide "nano-spike", designed to transform the incident light adiabatically into the fundamental mode of a 2-mm-long uniform section 1 µm in diameter, is used to achieve high launch efficiencies. The nano-spike is fully encapsulated in a fused silica cladding, protecting it from the environment. Nano-spikes provide a convenient means of launching light into sub-wavelength scale waveguides. Ultrashort (65 fs, repetition rate 100 MHz) pulses at wavelength 2 µm, delivered from a Tm-doped fiber laser, are launched with an efficiency ~12% into the sub-wavelength chalcogenide waveguide. Soliton fission and dispersive wave generation along the uniform section result in spectral broadening out to almost 4 µm for launched energies of only 18 pJ. The spectrum generated will have immediate uses in metrology and infrared spectroscopy.
Serpulina pilosicoli sp. nov., the Agent of Porcine Intestinal Spirochetosis (1996)

Phenotypic and genetic traits of porcine intestinal spirochete strain P43/6/78T (= ATCC 51139T) (T = type strain), which is pathogenic and weakly beta-hemolytic, were determined in order to confirm the taxonomic position of this organism and its relationships to previously described species of intestinal spirochetes. In BHIS broth, P43/6/78T cells had a doubling time of 1 to 2 h and grew to a maximum cell density of 2 x 10(9) cells per ml at 37 to 42 degrees C. They hydrolyzed hippurate, utilized D-glucose, D-fructose, sucrose, D-trehalose, D-galactose, D-mannose, maltose, N-acetyl-D-glucosamine, D-glucosamine, pyruvate, L-fucose, D-cellobiose, and D-ribose as growth substrates, and produced acetate, butyrate, ethanol, H2, and CO2 as metabolic products. They consumed substrate amounts of oxygen and had a G+C content (24.6 mol%) similar to that of Serpulina hyodysenteriae B78T (25.9 mol%). Phenotypic traits that could be used to distinguish strain P43/6/78T from S. hyodysenteriae and Serpulina innocens included its ultrastructural appearance (each strain P43/6/78T cell had 8 or 10 periplasmic flagella, with 4 or 5 flagella inserted at each end, and the cells were thinner and shorter and had more pointed ends than S. hyodysenteriae and S. innocens cells), its faster growth rate in liquid media, its hydrolysis of hippurate, its lack of beta-glucosidase activity, and its metabolism of D-ribose. DNA-DNA relative reassociation experiments in which the S1 nuclease method was used revealed that P43/6/78T was related to, but was genetically distinct from, both S. hyodysenteriae B78T (level of sequence homology, 25 to 32%) and S. innocens B256T (level of sequence homology, 24 to 25%). These and previous results indicate that intestinal spirochete strain P43/6/78T represents a distinct Serpulina species. Therefore, we propose that strain P43/6/78 should be designated as the type strain of a new species, Serpulina pilosicoli.
Laser induced photoelectrochemistry. Dependence of photoemission-related currents on laser characteristics (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLaser induced photoelectrochemistry. Dependence of photoemission-related currents on laser characteristicsJ. H. Richardson, S. M. George, J. E. Harrar, and S. P. PeroneCite this: J. Phys. Chem. 1978, 82, 16, 1818–1827Publication Date (Print):August 1, 1978Publication History Published online1 May 2002Published inissue 1 August 1978https://pubs.acs.org/doi/10.1021/j100505a008https://doi.org/10.1021/j100505a008research-articleACS PublicationsRequest reuse permissionsArticle Views68Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Erythroid precursors and progenitors suppress adaptive immunity and get invaded by SARS-CoV-2 (2020)

Abstract SARS-CoV-2 infection is associated with lower blood oxygen levels even in patients without hypoxia requiring hospitalization. This discordance illustrates the need for a more unifying explanation as to whether SARS-CoV-2 directly or indirectly affects erythropoiesis. Here we show significantly enriched CD71+ erythroid precursors/progenitors in the blood circulation of COVID-19 patients that have distinctive immunosuppressive properties. A subpopulation of abundant erythroid cells, CD45+CD71+cells, co-express ACE2, TMPRSS2, CD147, CD26 and these can be infected with SARS-CoV-2. In turn, pre-treatment of erythroid cells with dexamethasone significantly diminished ACE2/TMPRSS2 expression and subsequently reduced their infectivity with SARS-CoV-2. Taken together, pathological abundance of erythroid cells might reflect stress erythropoiesis due to the invasion of erythroid progenitors by SARS-CoV-2. This may provide a novel insight into the impact of SARS-CoV-2 on erythropoiesis and hypoxia seen in COVID-19 patients.
3D Beamforming for Spectral Coexistence of Satellite and Terrestrial Networks (2015)

Satellite communication (SatCom) is facing a spectrum scarcity problem due to the limited available exclusive spectrum and the high demand of the broadband satellite services. In this context, there has been an increasing interest in the satellite community to exploit the non- exclusive Ka-band spectrum in order to enhance the spectral efficiency of future broadband satellite systems. Herein, we propose a novel concept of enabling the spectral coexistence of satellite and terrestrial networks using three dimensional (3D) beamforming, which exploits the elevation dimension in addition to the commonly used azimuth dimension. The proposed beamforming solution is employed in a Multiple-Input Low Noise Block Downconverter (MLNB) based Feed Array Reflector (FAR) in contrast to the widely used Uniform Linear Array (ULA) structure. Within the employed antenna structure, the performance of the proposed beamforming solution is evaluated considering different feed arrangements. Finally, a database-assisted approach and two blind approaches are suggested for the effective implementation of the proposed solutions.
Opportunities to Improve the Prevention and Treatment of Cervical Cancer (2007)

Human papillomavirus (HPV) is a causal agent for approximately 5.3% of cancers worldwide, including cervical cancer, and subsets of genital and head and neck cancer. Persistent HPV infection is a necessary, but not sufficient, cause of cervical cancer. Of the >100 HPV genotypes, only about a dozen, termed "high-risk", are associated with cancer. HPV-16 is present in approximately 50% of all cervical cancers and HPV-16, HPV-18, HPV-31 and HPV-45 together account for approximately 80%. Most high-risk HPV infections are subclinical, and are cleared by the host's immune system. The remainder produces low or high-grade squamous intraepithelial lesions (SILs), also called cervical intraepithelial neoplasia (CIN), which also may regress spontaneously. However persistent high grade SIL represents the precursor lesion of cervical cancer and carcinogenic progression is associated with integration of the viral DNA, loss of E2 and upregulation of viral oncogene expression, and chromosomal rearrangements like 3q gain. Cytologic screening of the cervix for SIL and intervention has reduced the incidence of cervical cancer in the US by an estimated 80% and HPV viral DNA and other molecular tests may improve screening further. The licensure of a preventive HPV vaccine ushers in a new era, but issues remain, including: protection restricted to a few oncogenic HPV types, access in low resource settings and impact on current cytologic screening protocols. Importantly, preventive HPV vaccination does not help with current HPV infection or disease. Here we examine the potential of second-generation preventive HPV vaccines and therapeutic HPV vaccination to address these outstanding issues.
Diamidines for human African trypanosomiasis. (2010)

Aromatic diamidines are potent trypanocides. Pentamidine, a diamidine, has been used for more than 60 years to treat human African trypanosomiasis (HAT); however, the drug must be administered parenterally and is active against first-stage HAT only, prior to the parasites causing neurological deterioration through invasion of the CNS. A major research effort to design novel diamidines has led to the development of orally active prodrugs and, remarkably, a new generation of compounds that can penetrate the CNS. In this review, progress in the development of diamidines for the treatment of HAT is discussed.
Petabase-scale sequence alignment catalyses viral discovery (2022)

Public databases contain a planetary collection of nucleic acid sequences, but their systematic exploration has been inhibited by a lack of efficient methods for searching this corpus, which (at the time of writing) exceeds 20 petabases and is growing exponentially<sup>1</sup>. Here we developed a cloud computing infrastructure, Serratus, to enable ultra-high-throughput sequence alignment at the petabase scale. We searched 5.7 million biologically diverse samples (10.2 petabases) for the hallmark gene RNA-dependent RNA polymerase and identified well over 10<sup>5</sup> novel RNA viruses, thereby expanding the number of known species by roughly an order of magnitude. We characterized novel viruses related to coronaviruses, hepatitis delta virus and huge phages, respectively, and analysed their environmental reservoirs. To catalyse the ongoing revolution of viral discovery, we established a free and comprehensive database of these data and tools. Expanding the known sequence diversity of viruses can reveal the evolutionary origins of emerging pathogens and improve pathogen surveillance for the anticipation and mitigation of future pandemics.