gebhart/patrepeval huggingface dataset:
Profiling the N-Glycan Composition of IgG with Lectins and Capillary Nanogel Electrophoresis (2018)

Glycosylated human IgG contains fucosylated biantennary N-glycans with different modifications including N-acetylglucosamine, which bisects the mannose core. Although only a limited number of IgG N-glycan structures are possible, human IgG N-glycans are predominantly biantennary and fucosylated and contain varying levels of α2-6-linked sialic acid, galactose, and bisected N-acetylglucosamine. Monitoring the relative abundance of bisecting N-acetylglucosamine is relevant to physiological processes. A rapid, inexpensive, and automated method is used to successfully profile N-linked IgG glycans and is suitable to distinguish differences in bisection, galactosylation, and sialylation in N-glycans derived from different sources of human IgG. The separation is facilitated with self-assembled nanogels that also contain a single stationary zone of lectin. When the lectin specificity matches the N-glycan, the peak disappears from the electropherogram, identifying the N-glycan structure. The nanogel electrophoresis generates separation efficiencies of 500 000 plates and resolves the positional isomers of monogalactosylated biantennary N-glycan and the monogalactosylated bisected N-glycan. Aleuria aurantia lectin, Erythrina cristagalli lectin (ECL), Sambucus nigra lectin, and Phaseolus vulgaris Erythroagglutinin (PHA-E) are used to identify fucose, galactose, α2-6-linked sialic acid, and bisected N-acetylglucosamine, respectively. Although PHA-E lectin has a strong binding affinity for bisected N-glycans that also contain a terminal galactose on the α1-6-linked mannose branch, this lectin has lower affinity for N-glycans containing terminal galactose and for agalactosylated bisected biantennary N-glycans. The lower affinity to these motifs is observed in the electropherograms as a change in peak width, which when used in conjunction with the results from the ECL lectin authenticates the composition of the agalactosylated bisected biantennary N-glycan. For runs performed at 17 °C, the precision in migration time and peak area was less than or equal to 0.08 and 4% relative standard deviation, respectively. The method is compatible with electrokinetic and hydrodynamic injections, with detection limits of 70 and 300 pM, respectively.
Fully automatic feature localization for medical images using a global vector concentration approach (2008)

In this paper, we propose a novel feature localization method based on a global vector concentration approach. Our approach does not rely on the detection of local salient features around feature points. Instead, we exploit global structural information of the object extracted by calculating the concentration of directional vectors from sampling points. Those vectors are combined with local pattern descriptors of a query image and selected from preliminarily trained extended templates by nearest neighbor search. Due to the insensitivity of local changes, our method can handle partially occluded and noisy objects. We apply the proposed method to fully automatic feature localization of the left ventricular in echocardiograms. The results show the effectiveness of our method in comparison with a conventional edge-based method in terms of accuracy and robustness.
Characterizations of Ce-doped Y4Al2O9 Crystals for Scintillator Applications (2018)

Ce-doped Y 4 Al 2 O 9 (YAM) crystals were grown by the floating zone method, and several different characterizations were conducted for scintillator applications. Both photoluminescence (PL) and scintillation show emissions predominantly due to the 5d-4f transitions of Ce 3+ over 400-600 nm. The luminescence lifetime is approximately 10 ns for PL while the scintillation decay curve is best fitted by a second-order exponential decay function with the lifetimes of approximately 30 and 300 ns. These lifetimes are faster than that for Ce:Y 3 Al 5 O 12 (YAG) (~120 ns) and close to that of Ce:YAlO 3 (YAP) (~30 ns). The Ce-doped YAM shows a relatively high afterglow signal induced by X-rays (2 ms pulse) possibly due to the inclusion of a large number of defect centers. Pulse height spectroscopy was demonstrated under alpha-ray irradiation, and a successful sample showed a full-energy peak.
Increased Rates of Chorioamnionitis With Extra-Amniotic Saline Infusion Method of Labor Induction (2004)

II-2
Understanding the mechanism of aluminium nanoparticle oxidation (2006)

Aluminium nanoparticles have gained importance in the last decade because of their increased reactivity as compared with traditional micron-sized particle. The physics of burning of aluminium nanoparticle is expected to be different than that of micron-sized particles, and the current article is motivated by these differences. We have previously measured the size resolved reactivity of nanoaluminium by single-particle mass spectrometry, to which we now add transmission electron microscope (TEM) and an on-line density measurement. The latter two studies revealed the presence of hollow particles following oxidation of nanoaluminium and indicating the significance of diffusion of aluminium in the overall process. Based on experimental evidence, we believe that aluminium nanoparticle oxidation occurs in two regimes. Prior to melting of aluminium slow oxidation occurs through the diffusion of oxygen through the aluminium oxide shell. Above the melting point, we transition to a fast oxidation regime whereby both aluminium and oxygen diffuse through the oxide shell to enhance the oxidation rate. We also develop a phenomenological model for nanoaluminium oxidation that accounts for the experimentally observed rates, the fact that both fuel and oxidizer are diffusing, and a new effect related to internal pressure gradients. The latter phenomen is based on molecular dynamic simulations suggesting that there are large pressure gradients present inside these particles, with the aluminium core under a positive pressure and the aluminium oxide shell under a negative pressure. We have considered the effect of these pressure gradients on the oxidation process. A power law relation was obtained (t ∝ r 1.6± 0.1) between the time required for oxidation and particle radius.
3D environment modeling from multiple cylindrical panoramic images (2020)

A traditional approach to extracting geometric information from a large scene is to compute multiple (possibly numerous) 3D depth maps from stereo pairs, and then to merge the 3D data [71, 109, 210, 255]. This is not only computationally intensive, but the resulting merged depth maps may be subject to merging errors, especially if the relative poses between depth maps are not known exactly. The 3D data may also have to be resampled before merging, which adds additional complexity and potential sources of errors. 3D data registration and merging are very much simplified if the motion of the stereo pair is known. One simple instance of this is fixing the location of the center of the reference camera of a stereo pair and constraining the motion of the stereo pair to rotation about the vertical axis. However, unless a motorized rotary table is used to control the amount of rotation, the rotation between successive stereo views still has to be estimated. There is still the same (but much more constrained) problem of registration and 3D resampling, albeit with only one rotational degree of freedom.
Adenoviral Vector-Mediated Expression of Physiologic Levels of Human Factor VIII in Nonhuman Primates (1999)

An E1-, E2a-, E3-deleted adenoviral vector (Av3H82) encoding an epitope-tagged B domain-deleted human factor VIII cDNA (flagged FVIII) was evaluated in nonhuman primates. Twelve cynomolgus monkeys received intravenous administration of Av3H82; 6 monkeys received 6 x 10(11) particles/kg and another 6 received 3 x 10(12) particles/kg. Adenoviral vector transduction of the liver was efficient, reproducible, and linearly dose dependent. Physiologic levels of flagged FVIII were readily detected in plasma samples obtained from monkeys that received the higher dose of vector and human FVIII mRNA was detected in their livers. Expression of transgene mRNA was restricted to the liver by the albumin promoter. Although vector DNA was readily detected in the liver of monkeys that received the lower dose, neither human FVIII mRNA nor flagged FVIII protein could be detected. Vector distribution was widespread, with the highest levels observed in liver and spleen. Histopathology, hematology, and serum chemistry analysis identified the liver and blood as major sites of toxicity. Transient mild serum elevations of liver enzymes were observed, along with a dose-dependent inflammatory response in the liver. In addition, mild lymphoid hyperplasia was observed in the spleen. Mild anemia and a transient decrease in platelet count were observed, as was marrow hyperplasia and extramedullary hematopoiesis.
Full wetting of plasmonic nanopores through two-component droplets (2015)

Benefiting from the prospect of extreme light localization, plasmonic metallic nanostructures are bringing advantages in many applications. However, for use in liquids, the hydrophobic nature of the metallic surface inhibits full wetting, which is related to contact line pinning in the nanostructures. In this work, we use a two-component droplet to overcome this problem. Due to a strong internal flow generated from the solutal Marangoni effect, these droplets can easily prime metallic nanostructures including sub-10 nm nanopores. We subsequently evaluate the local wetting performance of the plasmonic structures using surface enhanced Raman spectroscopy (SERS). Compared with other commonly used surface cleaning based wetting methods such as the oxygen plasma treatment, our two-component drop method is an efficient method in resolving the pinning of contact lines and is also non-destructive to samples. Thus the method described here primes plasmonic devices with guaranteed performances in liquid applications.
Clostridium sordellii infection and toxin neutralization (1990)

GRIMWOOD, KEITH MD, FRACP; EVANS, GERALD A. MD, FRCPC; GOVENDER, S. THIRU MD, FRCPC; WOODS, DONALD E. PHD
Detection of the Hardcoded Login Information from Socket Symbols (2020)

Internet of Things (IoT) for smart homes enhances the convenience of our life; however, it also introduces the risk of leakage of privacy data in the house. A user wants to protect their privacy data from leakage. However, the analysis of IoT devices requires technical knowledge; therefore, it is challenging for the users to detect any vulnerability by themselves. In this study, we propose a lightweight method to detect the hardcoded username and password in IoT devices using static analysis. This method can detect the 1st vulnerability from 2018 OWASP TOP 10 for the IoT device. The hardcoded login information can be obtained by comparing the user input with strcmp or strncmp. Thus, previous studies analyzed the symbols of strcmp or strncmp to detect the hardcoded login information. However, these studies require time because of the usage of complicated algorithms such as symbolic execution. To develop a lightweight algorithm, we focus on a network function, such as the socket symbol in firmware, because the IoT device is compromised when it is invaded by someone via the Internet. We propose two methods to detect the hardcoded login information, i.e., string search and socket search. In string searching, it finds a function that uses strcmp or strncmp symbol. In socket searching, it finds a function that is referenced by socket symbol. In the experiment, we measured the ability of our method by searching six firmware in the real world that has a backdoor. we ran three methods: string search, socket search, and whole search to compare two methods. As a result, all methods found login information from four of six firmware. Our method reduces an analysis time that when the whole search takes 38mins to complete, our methods finish 4-6min.
Insights Into Onchocerca volvulus Population Biology Through Multilocus Immunophenotyping (2017)

We have developed a serologically based immunophenotyping approach to study Onchocerca volvulus (Ov) population diversity. Using genomic sequence data and polymerase chain reaction-based genotyping, we identified nonsynonymous single-nucleotide polymorphisms (SNPs) in the genes of 16 major immunogenic Ov proteins: Ov-CHI-1/Ov-CHI-2, Ov16, Ov-FAR-1, Ov-CPI-1, Ov-B20, Ov-ASP-1, Ov-TMY-1, OvSOD1, OvGST1, Ov-CAL-1, M3/M4, Ov-RAL-1, Ov-RAL-2, Ov-ALT-1, Ov-FBA-1, and Ov-B8. We assessed the immunoreactivity of onchocerciasis patient sera (n = 152) from the Americas, West Africa, Central Africa, and East Africa against peptides derived from 10 of these proteins containing SNPs. Statistically significant variation in immunoreactivity among the regions was seen in SNP-containing peptides derived from 8 of 10 proteins tested: OVOC1192(1-15), OVOC9988(28-42), OVOC9225(320-334), OVOC7453(22-36), OVOC11517(14-28), OVOC3177(283-297), OVOC7911(594-608), and OVOC12628(174-188). Our data show that differences in immunoreactivity to variant antigenic peptides may be used to characterize Ov populations, thereby elucidating features of Ov population biology previously inaccessible because of the limited availability of parasite material.
Prolonged response to treatment based on cell-free DNA analysis and molecular profiling in three patients with metastatic cancer: a case series (2021)

www.clinicaltrials.gov (NCT02152254). Registered May 28, 2014. https://www.clinicaltrials.gov/ct2/show/NCT02152254. MD Anderson protocol # PA12-1161 (approval ID IRB1 FWA00000121) and # PA11-0377 (approval ID IRB4 FWA00005015).
Fixing the program my computer learned (2009)

The results of a machine learning from user behavior can be thought of as a program, and like all programs, it may need to be debugged. Providing ways for the user to debug it matters, because without the ability to fix errors users may find that the learned program's errors are too damaging for them to be able to trust such programs. We present a new approach to enable end users to debug a learned program. We then use an early prototype of our new approach to conduct a formative study to determine where and when debugging issues arise, both in general and also separately for males and females. The results suggest opportunities to make machine-learned programs more effective tools.
A Parimutuel-like Mechanism for Information Aggregation: Forecasting Inside Intel (2013)

We evaluate the performance of an information aggregation mechanism (IAM) implemented inside Intel to forecast unit sales for the company. Developed, rened and tested in the laboratory using experimental methods, the IAM is constructed from institutional features that improve performance and overcome barriers to successful applications of other information aggregation methods. Its implementation at Intel provides a testbed for evaluating this new form of IAM’s performance in a complex eld environment. In contrast to prediction markets, which provide only a point forecast of future sales, the IAM characterizes the full distribution of participants’ aggregated beliefs allowing a more detailed evaluation of its performance. We show this predictive distribution very closely matches the distribution over outcomes at short horizons while slightly underweighting low-probability realizations of unit sales at long horizons. Compared to Intel’s \ocial forecast, the IAM forecasts perform well overall, even though they predate the ocial forecasts. The forecast improvements are most prominent at short forecast horizons and in direct distribution channels, where the eective aggregation of individually-held information drives the IAM to be more accurate than the ocial forecast over 75% of the time.
Investigation of Ductile Fracture Mechanism in Multipass Drawing of Hollow Specimen (2021)

To apply hollow forming technology for car parts, it is necessary to understand the ductile fracture mechanism of hollow forming. In this study, the cold drawing test and the finite element method analysis (FEM) of hollow specimens were carried out. It was clarified that the ductile fracture of hollow specimens in cold drawing was affected by both stress triaxiality and Lode angle parameter. As a result of fracture observation of a hollow specimen, an equiaxed dimple and an elongated dimple were observed. A mixed-mode ductile fracture mechanism (shear deformation of voids and typical void growth and coalescence) for hollow specimens in cold drawing is assumed.
Automated classification of breast cancer morphology in histopathological images (2013)

From 11th European Congress on Telepathology and 5th International Congress on Virtual Microscopy Venice, Italy. 6-9 June 2012
Synthesis and bacterial DNA gyrase inhibitory properties of a spirocyclopropylquinolone derivative (1988)

A novel conformationally restricted 1-cyclopropylquinolone (1) that incorporates structural features of both ofloxacin and ciprofloxacin has been prepared. Compound 1 was found to be a DNA gyrase inhibitor having potency similar to ofloxacin but less than ciprofloxacin. The cellular inhibitory and in vivo antibacterial potencies of 1 were found to be less than those of the two reference agents.
Le cathétérisme bilatéral des sinus pétreux avec dosages multihormonaux dans la maladie de Cushing (2002)

Comite de redactionA. Belcourt (Strasbourg),M.-H. Bernard (Lyon)Ph. Bouchard (Paris), J. Bringer (Montpellier), T. Brue (Marseille), J.-M. Brun (Dijon), M. Chupin (Nantes),B. Delemer (Reims), N. Jeandidier (Strasbourg), V. Lassmann-Vague (Marseille),J. Leclere (Nancy), P. Lecomte (Tours),P. Lefebvre (Liege), Y. Lorcy (Rennes), Y. Morel (Lyon), H. Rochefort (Montpellier), V. Rohmer (Angers), J.-L. Sadoul (Nice), J. Saez (Lyon), G. Slama (Paris), H. Vaudry (Mont Saint-Aignan), J.-L. Wemeau (Lille), G. Weryha (Vandœuvre), Indexe dans, Indexed in : Biosis, Chemical Abstract, Current Contents/Life Sciences, EMBASE/Excerpta Medica, Elsevier BIOBASE/Current Awareness in Biological Sciences, Medline (Index Medicus), Pascal (INIST/CNRS), SCI Search, Science Citation Index, Research Alert.Edition120, boulevard Saint-Germain75280 Paris cedex 06Tel. : +33 (0)1 40 46 62 00 Fax : +33 (0)1 40 46 62 01AbonnementsSESJM : BP22- F41354 VineuilTel. +33 (0) 2 54 50 46 12Fax : +33(0) 2 54 50 46 111999 - 6 numerosFrance : 1 30 8 FFEtudiants (sur justificatif) : 654 FFAutres pays : 1 584 FFPrix du numero : 287 FFLes abonnements sont mis en service dans un delai maximum de quatre semaines apres reception de la commande et du reglement. Ils partent du premier numero de l’annee.Les reclamations pour les numeros non recus doivent parvenir dans un delai maximum de six mois.Les numeros separes de l’annee et volumes anterieurs (jusqu’a epuisement du stock) peuvent etre commandes a la meme adresse.EDITEURFreya WeiseTel. : (33) 01 40 46 62 08Fax : (33) 01 40 46 61 61e-mail : f.weise@masson.frASSISTANTE EDITORIALEPauline BocquillonTel. : (33) 01 40 46 62 49Fax : (33) 01 40 46 61 61e-mail : p.bocquillon@masson.frREGIE PUBLICITAIREMarie-Pierre CancelTel. : (33) 01 40 46 62 93Fax : (33) 01 40 46 62 21DIRECTEUR DE LA PUBLICATIONP. DutilleulAE012002Vol.63 ;n° 1Bialec
Comparison of Ni- and SiGe-based MEMS magnetometers (2012)

The goal of this research is to design and fabricate a very sensitive MEMS-based magnetic field sensor for space applications. The challenge is to reach the required sensitivity: measuring magnetic fields from a few nT to about 60000nT with sub-nano Tesla accuracy. The device studied in this paper is based on a classical resonating Xylophone Bar Magnetometer (XBM). It consists of a free-free beam supported in the nodal points of the fundamental transverse mode of vibration. A sinusoidal current at the vibration frequency is supplied via the nodal supports. In the presence of an external magnetic field, this current results in a sinusoidal Lorentz force that puts the XBM in vibration at its fundamental frequency. Two different materials are proposed to fabricate this device: the first one is Poly-SiGe and the second is Nickel. The paper will present multi-physics simulations to evaluate the response of the SiGe-XBM and the Ni-XBM. Following these studies, devices with several support lengths and shapes were designed and fabricated in poly-SiGe and Nickel. Increasing the quality factor by a dedicated design of the support and using the intrinsic properties of the material, the new magnetometer will have improved accuracy and resolution and will meet the requirements for space applications.
Bacterial Outer Membrane Vesicles Induce Vitronectin Release Into the Bronchoalveolar Space Conferring Protection From Complement-Mediated Killing (2018)

Pathogens causing pneumonia utilize the complement regulator vitronectin to evade complement-mediated killing. Although vitronectin is associated with several chronic lung diseases, the role of bronchoalveolar vitronectin in pneumonia has not been studied. This study sought to reveal the involvement of vitronectin in the bronchoalveolar space during pneumonia, to assess the effect of outer membrane vesicles and endotoxin on vitronectin release, and to determine whether bacterial pathogens utilize pulmonary vitronectin for evasion. Vitronectin was analyzed in cell-free bronchoalveolar lavage fluid harvested from patients with pneumonia (n=8) and from healthy volunteers after subsegmental endotoxin instillation (n=13). Vitronectin binding by Pseudomonas aeruginosa and Haemophilus influenzae was analyzed, and subsequent complement evasion was assessed by serum challenge. The effects of outer membrane vesicles on vitronectin production in mouse lungs and human type II alveolar epithelial cells (A549) were determined. We detected increased vitronectin concentrations in lavage fluid during pneumonia (p=0.0063) and after bronchial endotoxin challenge (p=0.016). The capture of vitronectin by bacteria significantly reduced complement-mediated lysis. Following challenge with vesicles, vitronectin was detected in mouse bronchoalveolar space and mouse alveolar epithelial cells in vivo as well as A549 cells in vitro contained increased levels of vitronectin. Taken together, outer membrane vesicles and endotoxin from Gram-negative bacteria induce vitronectin, which is released into the bronchoalveolar space, and used for evasion of complement-mediated clearance.
Circulating Cells Contribute to Cardiomyocyte Regeneration After Injury (2014)

These results suggest that circulating cells participate in cardiomyocyte regeneration in a mouse model of parabiosis when the circulatory system is fully developed before surgery-induced heart injury.
Practical Large-Scale Optimization for Max-norm Regularization (2010)

The max-norm was proposed as a convex matrix regularizer in [1] and was shown to be empirically superior to the trace-norm for collaborative filtering problems.&#13;\nAlthough the max-norm can be computed in polynomial time, there are currently no practical algorithms for solving large-scale optimization problems that incorporate&#13;\nthe max-norm. The present work uses a factorization technique of Burer and Monteiro [2] to devise scalable first-order algorithms for convex programs&#13;\ninvolving the max-norm. These algorithms are applied to solve huge collaborative filtering, graph cut, and clustering problems. Empirically, the new methods&#13;\noutperform mature techniques from all three areas.
Artemisinin-Based Combination Anti-malarials Do Not Enhance Anti-melanoma Activity of Artemisinin-Monotherapy (2013)

Class of 2013 Abstract
Chiral 1,1′-Diphosphetanylferrocenes: New Ligands for Asymmetric Catalytic Hydrogenation of Itaconate Derivatives (2000)

The useful combination of high catalytic activity and high enantioselectivity is provided by rhodium catalysts based on a new class of FerroTANE ligands when employed in the hydrogenation of itaconate derivatives (see scheme). Reactions performed at S/C ratio of 20 000 are complete within 3 h and directly afford valuable 2-alkylsuccinamide products in up to 99 % enantiomeric excess.