gebhart/patrepeval huggingface dataset:
A 12 Gb/s 0.9 mW/Gb/s Wide-Bandwidth Injection-Type CDR in 28 nm CMOS With Reference-Free Frequency Capture (2016)

A wide band, low power, injection-locked oscillator (ILO)-type clock and data recovery (CDR) with high jitter tolerance is implemented in 28 nm CMOS. A robust phase and frequency detection algorithm independently controls ILO free running frequency and clock phase without an external time reference. A wide capture range of -25/+15% enables reference-free frequency acquisition. Jitter tolerance is 0.56 UI at 300 MHz and 1 UI at 120 MHz, with 2 UI locking time after optional calibration. The CDR operates from 1 to 12 Gbps, consuming 11 mW from 0.9 V supply at 12 Gbps for a power efficiency of 0.9 mW/Gbps. A comparison with published results shows a substantial improvement on the trend of wide CDR bandwidth coupled to degraded power efficiency.
Bordetella bronchiseptica and Bordetella pertussis: Similarities and Differences in Infection, Immuno-Modulation, and Vaccine Considerations (2023)

<i>Bordetella pertussis</i> and <i>Bordetella bronchiseptica</i> belong to the genus <i>Bordetella</i>, which comprises 14 other species. <i>B. pertussis</i> is responsible for whooping cough in humans, a severe infection in children and less severe or chronic in adults. These infections are restricted to humans and currently increasing worldwide. <i>B. bronchiseptica</i> is involved in diverse respiratory infections in a wide range of mammals. For instance, the canine infectious respiratory disease complex (CIRDC), characterized by a chronic cough in dogs. At the same time, it is increasingly implicated in human infections, while remaining an important pathogen in the veterinary field. Both <i>Bordetella</i> can evade and modulate host immune responses to support their persistence, although it is more pronounced in <i>B. bronchiseptica</i> infection. The protective immune responses elicited by both pathogens are comparable, while there are important characteristics in the mechanisms that differ. However, <i>B. pertussis</i> pathogenesis is more difficult to decipher in animal models than those of <i>B. bronchiseptica</i> because of its restriction to humans. Nevertheless, the licensed vaccines for each <i>Bordetella</i> are different in terms of formulation, route of administration and immune responses induced, with no known cross-reaction between them. Moreover, the target of the mucosal tissues and the induction of long-lasting cellular and humoral responses are required to control and eliminate <i>Bordetella</i>. In addition, the interaction between both veterinary and human fields are essential for the control of this genus, by preventing the infections in animals and the subsequent zoonotic transmission to humans.
Supplementary Figure S6 from Preclinical Antitumor Efficacy of BAY 1129980—a Novel Auristatin-Based Anti-C4.4A (LYPD3) Antibody–Drug Conjugate for the Treatment of Non–Small Cell Lung Cancer (2023)

&lt;p&gt;Concentration of C4.4A-ADC metabolite BAY 1136309 in NCI-H292 tumors in mice after administration of C4.4A-ADC.&lt;/p&gt;
On the Separability of Ergodic Fading MIMO Channels: A Lattice Coding Approach (2018)

This paper addresses point-to-point communication over block-fading channels with independent fading blocks. When both channel state information at the transmitter and receiver (CSIR) are available, most achievable schemes use separable coding, i.e., coding independently and in parallel over different fading states. Unfortunately, separable coding has drawbacks, including large memory requirements at both communication ends. In this paper, a lattice coding and decoding scheme is proposed that achieves the ergodic capacity without separable coding, with lattice codebooks and decoding decision regions that are universal across channel realizations. We first demonstrate this result for fading distributions with discrete, finite support whose sequences are robustly typical. Results are then extended to continuous fading distributions, as well as multiple-input multiple-output (MIMO) systems. In addition, a variant of the proposed scheme is presented for the MIMO ergodic fading channel with CSIR only, where we prove the existence of a universal codebook that achieves rates within a constant gap to capacity for finite-support fading distributions. The gap is small compared with other schemes in the literature. Extension to continuous-valued fading is also provided.
Eryptosis in Patients with Chronic Kidney Disease: A Possible Relationship with Oxidative Stress and Inflammatory Markers (2022)

Background. Eryptosis is the programmed death of red blood cells; it may contribute to worsening anemia in chronic kidney disease (CKD). In this clinical condition, different factors induce eryptosis, such as oxidative stress, energy depletion and uremic toxins. In our study, we investigated if the progression of CKD may influence erythrocyte death levels and its relationship with oxidative stress and inflammation. Methods. We evaluated eryptosis levels in 25 CKD patients (five for each stage), as well as markers of oxidative stress and inflammation: myeloperoxidase (MPO), copper/zinc superoxide dismutase (Cu/Zn SOD) and interleukin-6 (IL-6) were evaluated in plasma samples. Results. Higher cell death rate was reported in the highest CKD stages (p < 0.05). Furthermore, we divided CKD patients into two groups (eGFR< or ≥60 mL/min/1.73 m2). Patients with eGFR < 60 mL/min/1.73 m2 had higher eryptosis levels (p < 0.001). MPO, CU/Zn SOD and IL-6 resulted significantly differently between groups (p < 0.001). Significant positive correlations were reported between eryptosis and MPO (Spearman’s rho = 0.77, p = 0.01) and IL-6 (Spearman’s rho = 0.52, p = 0.05) and Cu/Zn SOD. Spearman’s rho = 0.6, p = 0.03). Conclusions. In patients with CKD, different factors are involved in the pathogenesis of eryptosis, in particular uremic toxins and oxidative stress and inflammatory markers. The progressive impairment of renal function may be associated with the increase in eryptosis levels, probably due to the accumulation of oxidative stress factors, inflammatory cytokines and uremic toxins.
3 Analysis of Metabolic Networks Metabolic Flux Analysis (2003)

The measurement or estimation of metabolic fluxes is useful for the evaluation of metabolic networks and their control. In isotope tracer methods, the cells to be studied are provided with a substrate specifically labeled with a detectable isotope. Flux estimation based only on material balances is identical, in principle, to flux estimation using isotopic tracers and has been applied to many biochemical processes, including lysine synthesis and rat heart metabolism. The magnitude of the control coefficient is a measure of how important a particular enzyme is in the determination of the steady-state flux. The challenge in analyzing a metabolic network is determination of the flux control coefficients. It is possible to determine them directly by “enzyme titration” combined with the measurement of the new steady-state flux. Metabolic control analysis, especially with the innovations for determining flux control coefficients, is a powerful tool for the analysis of metabolic networks.
FIBRIN GLUE-OXIDIZED CELLULOSE SANDWICH FOR LAPAROSCOPIC WEDGE RESECTION OF SMALL RENAL LESIONS (2005)

Small exophytic or mesophytic renal lesions can be safely excised laparoscopically without vessel clamping. Excellent hemostasis was achieved in each case with the newer hemostatic agents.
Autonomous relocation strategies for cells on wheels in public safety networks (2017)

Lack of network availability or limited access to communication services are among the challenges that public safety officials and first responders could face during disasters. Networking infrastructure can partially (or sometimes fully) breakdown during a catastrophe. At the same time, unusual peaks in traffic load could lead to much higher blocking probability for critical communication. A possible solution for such scenarios is through the use of mobile infrastructures commonly referred to as Cells on Wheels (COW) or Cells on Light Trucks (COLT). These mobile cells can effectively complement the existing undamaged infrastructure or enable a temporary emergency network by themselves. Given the limited capacity of each cell, variable and spatially non-uniform traffic across the disaster area can make a big impact on the network performance. Not only judicious deployment of the cells can help to meet the coverage and capacity demands across the area, but also intelligent relocation strategies can optimally match the network resources to potentially changing traffic demands. Assuming that each cell can autonomously change its location, in this paper, we propose a decentralized relocation algorithm that adapts network coverage in order to increase the supported users traffic.
Supplementary Table 3 from Multilevel Whole-Genome Analysis Reveals Candidate Biomarkers in Clear Cell Renal Cell Carcinoma (2023)

&lt;p&gt;PDF file - 50K, Significantly expressed genes located on the 3p and 5q chromosomal arms among aberrant versus normal kidney and integration of protein and miRNA data in ccRCC&lt;/p&gt;
Use of diffractive lenses in lithographic projection lenses (2006)

Diffractive lenses are very useful to correct chromatic aberrations of lithographic projection lenses. In addition they provide the possibility to correct the Petzval curvature although they do not deliver their own contribution to it.
Simultaneous Determination of Celecoxib, Erlotinib, and its Metabolite Desmethyl-Erlotinib (OSI-420) in Rat Plasma by Liquid Chromatography/Tandem Mass Spectrometry with Positive/Negative Ion-Switching Electrospray Ionisation (2012)

A new method for the simultaneous determination of celecoxib, erlotinib, and its active metabolite desmethyl-erlotinib (OSI-420) in rat plasma, by liquid chromatography/tandem mass spectrometry with positive/negative ion-switching electrospray ionization mode, was developed and validated. Protein precipitation with methanol was selected as the method for preparing the samples. The analytes were separated on a reverse-phase C(18) column (50mm×4.6mm i.d., 3μ) using methanol: 2 mM ammonium acetate buffer, and pH 4.0 as the mobile phase at a flow rate 0.8 mL/min. Sitagliptin and Efervirenz were used as the internal standards for quantification. The determination was carried out on a Theremo Finnigan Quantam ultra triple-quadrupole mass spectrometer, operated in selected reaction monitoring (SRM) mode using the following transitions monitored simultaneously: positive m/z 394.5→278.1 for erlotinib, m/z 380.3→278.1 for desmethyl erlotinib (OSI-420), and negative m/z -380.1→ -316.3 for celecoxib. The limits of quantification (LOQs) were 1.5 ng/mL for Celecoxib, erlotinib, and OSI-420. Within- and between-day accuracy and precision of the validated method were within the acceptable limits of < 15% at all concentrations. The quantitation method was successfully applied for the simultaneous estimation of celecoxib, erlotinib, and desmethyl erlotinib in a pharmacokinetic study in Wistar rats.
A MIMO Symbol Rate Signal Digital Predistorter for Nonlinear Multicarrier Satellite Channels (2015)

peer reviewed
Veni Vidi Dixi: Reliable Wireless Communication with Depth Images (2019)

The upcoming industrial revolution requires deployment of critical wireless sensor networks for automation and monitoring purposes. However, the reliability of the wireless communication is rendered unpredictable by mobile elements in the communication environment such as humans or mobile robots which lead to dynamically changing radio environments. Changes in the wireless channel can be monitored with frequent pilot transmission. However, that would stress the battery life of sensors. In this work a new wireless channel estimation technique, Veni Vidi Dixi, VVD, is proposed. VVD leverages the redundant information in depth images obtained from the surveillance cameras in the communication environment and utilizes Convolutional Neural Networks CNNs to map the depth images of the communication environment to complex wireless channel estimations. VVD increases the wireless communication reliability without the need for frequent pilot transmission and with no additional complexity on the receiver. The proposed method is tested by conducting measurements in an indoor environment with a single mobile human. Up to authors best knowledge our work is the first to obtain complex wireless channel estimation from only depth images without any pilot transmission. The collected wireless trace, depth images and codes are publicly available.
Intein‐mediated protein assembly in transgenic wheat: production of active barnase and acetolactate synthase from split genes (2009)

Engineering traits by the assembly of non-functional gene products is a promising tool for modern plant biotechnology. In this article, we describe the establishment of male sterility and herbicide resistance in wheat (Triticum aestivum) by complementing inactive precursor protein fragments through a split intein system. N- and C-terminal fragments of a barnase gene from Bacillus amyloliquifaciens were fused to intein sequences from the Synechocystis sp. gene DnaB and delivered into the wheat genome via biolistic particle bombardment. Both barnase fragments were expressed under the control of a tapetum-specific promoter. High efficiency of the split barnase system was achieved by introducing GGGGS linkers between the fusion domains of the assembled protein. Depending on the vector version that was transformed, up to 51% of primary transformed plants produced sterile pollen. In the F(1) progeny, the male-sterile phenotype segregated with both barnase gene fragments. Expression of the cytotoxic barnase in the tapetum did not apparently affect the vegetative phenotype and remained stable under increased temperatures. In addition, the reconstitution of sulphonylurea resistance was achieved by DnaE intein-mediated assembly of a mutated acetolactate synthase (ALS) protein from rice. The impacts of the technical advances revealed in this study on the concepts for trait control, transgene containment and hybrid breeding are discussed.
Superior Oxygen Electrocatalysis on Nickel Indium Thiospinels for Rechargeable Zn–Air Batteries (2019)

Developing active bifunctional oxygen catalysts to eliminate/reduce the reliance on precious-metal-based ones in metal–air batteries is nowadays of great importance. Here, we report the synthesis of nickel indium thiospinel nanosheets supported on carbon nanofibers (denoted as NiIn2S4/CNFs) via a facile in situ solvothermal growth process and, for the first time, demonstrate its superior bifunctional oxygen electrocatalytic performances as a precatalyst. Electrocatalytic experiments show that NiIn2S4/CNFs not only exhibits a positive half-wave potential of 0.81 V for the oxygen reduction reaction (ORR) but also delivers a lower overpotential of 0.39 V for the oxygen evolution reaction (OER) at 10 mA cm–2, outperforming those of monometallic Ni or In sulfides. Theoretical calculations confirm that the (220) and (111) plane in NiIn2S4 are selectively active to the ORR and OER, respectively. Apart from the intrinsic nature of NiIn2S4, the superior OER activity of NiIn2S4/CNFs is also related to the oxide/hydroxide species in-situ-formed on NiIn2S4 surface under the OER condition. Moreover, the developed NiIn2S4/CNFs pre-catalyst is demonstrated to be an efficient air-cathode for Zn–air batteries. This work brings a new perspective for designing various ternary thiospinels for energy conversion and storage.
Demonstration of a second ligand for the low affinity receptor for immunoglobulin E (CD23) using recombinant CD23 reconstituted into fluorescent liposomes. (1992)

Recombinant full-length human CD23 has been incorporated into fluorescent liposomes to demonstrate the existence of a ligand for CD23 that is different from the previously known ligand, immunoglobulin E (IgE). The novel ligand for CD23 is expressed on subsets of normal T cells and B cells as well as on some myeloma cell lines. The interaction of full-length CD23 with its ligand is specifically inhibited by anti-CD23 monoclonal antibodies and by IgE, and it is Ca2+ dependent. Moreover, tunicamycin treatment of a CD23-binding cell line, RPMI 8226, significantly reduced the binding of CD23 incorporated into fluorescent liposomes, and a sugar, fucose-1-phosphate, was found to inhibit CD23-liposome binding to RPMI 8226 cells, suggesting the contribution of sugar structures on the CD23 ligand. In addition, CD23-transfected COS cells were shown to form specific conjugates with the cell line RPMI 8226. These data demonstrate that CD23 interacts with a ligand, which is different from IgE, and that CD23 can be considered as a new surface adhesion molecule involved in cell-cell interactions.
Elevated circulatory level of GABAA – antagonistic neurosteroids in patients with combat-related post-traumatic stress disorder (2000)

Chronic CR-PTSD may be associated with increased circulatory level of neuroactive steroids with inhibitory activity at the GABA(A) receptors. Neurosteroid-induced decreased GABAergic tone may be relevant to the symptomatology and pathophysiology of chronic PTSD, as well as to the frequent co-morbidity of PTSD with depression and anxiety disorders.
The surface of the empirical horopter (2008)

The distribution of empirical corresponding points in the two retinas has been well studied along the horizontal and the vertical meridians, but not in other parts of the visual field. Using an apparent-motion paradigm, we measured the positions of those points across the central portion of the visual field. We found that the Hering-Hillebrand deviation (a deviation from the Vieth-Müller circle) and the Helmholtz shear of horizontal disparity (backward slant of the vertical horopter) exist throughout the visual field. We also found no evidence for non-zero vertical disparities in empirical corresponding points. We used the data to find the combination of points in space and binocular eye position that minimizes the disparity between stimulated points on the retinas and the empirical corresponding points. The optimum surface is a top-back slanted surface at medium to far distance depending on the observer. The line in the middle of the surface extending away from the observer comes very close to lying in the plane of the ground as the observer fixates various positions in the ground, a speculation Helmholtz made that has since been misunderstood.
Using mm-Waves for Secret Key Establishment (2019)

The fact that millimeter-wave (mmWave) communication needs to be directional is usually perceived as a challenge; in this letter, we argue that it enables efficient secret key sharing that is unconditionally secure from passive eavesdroppers by building on packet erasures. We showcase the potential of our approach in two setups: 5G networks and vehicle platooning. In both cases, with the right choice of parameters, we can potentially establish keys in the order of tenths of Mb/s. These first results are based on some simplifying assumptions, yet we believe that they give incentives to further explore such techniques.
Low-Complexity Nonlinearity Compensation for Short-Reach IM/DD Systems using PAM (2021)

We investigate the performance of non-regular PAM8 constellations and introduce a novel non-uniformly quantized equalizer to improve nonlinearity compensation in 70 GBd PAM8 back-to-back and 1 km SSMF transmission without additional complexity.
Farnesyltransferase inhibitors induce dramatic morphological changes of KNRK cells that are blocked by microtubule interfering agents (1998)

Farnesyltransferase inhibitors (FTIs) exhibit the remarkable ability to inhibit transformed phenotypes of a variety of human cancer cell lines and to block the growth of cancer cells in a number of animal model systems. In this paper, we report that the addition of FTI to v-K-ras- transformed NRK cells (KNRK) results in dramatic morphological changes. Within 24 h after the addition of FTI, the round morphology of KNRK cells was changed to an elongated (flattened and spread out) morphology resembling those of untransformed NRK cells. No morphological effects were seen when similar concentrations of FTI were added to NRK cells. Phalloidin staining showed that FTI treatment did not restore the disrupted actin cytoskeleton in KNRK cells. In contrast, FTI addition resulted in the appearance of extensive microtubule networks in KNRK cells. The addition of a low concentration (1.2 nM) of vincristine or vinblastine, agents that interfere with microtubule dynamics, blocked the FTI-induced morphological changes in KNRK cells. In contrast, cytochalasin B, which interferes with actin polymerization, did not block the morphological changes. The FTI-induced morphological changes were associated with a decrease in the percentage of cells in S-phase, and the addition of 1.2 nM vincristine did not have additional effects on cell cycle progression. A higher concentration (12 nM) of vincristine caused synergistic effect with FTI to enrich dramatically KNRK cells in G2/M phase. These results suggest that FTI affects cell morphology and that microtubule dynamics are involved in these processes.
Simple low-valent amido, imido and nitrido complexes of tungsten (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSimple low-valent amido, imido and nitrido complexes of tungstenPedro J. Perez, Li Luan, Peter S. White, M. Brookhart, and J. L. TempletonCite this: J. Am. Chem. Soc. 1992, 114, 20, 7928–7929Publication Date (Print):September 1, 1992Publication History Published online1 May 2002Published inissue 1 September 1992https://pubs.acs.org/doi/10.1021/ja00046a059https://doi.org/10.1021/ja00046a059research-articleACS PublicationsRequest reuse permissionsArticle Views313Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Uncertainty in techno-economic estimates of cellulosic ethanol production due to experimental measurement uncertainty (2012)

We calculate a $0.15/gal uncertainty in MESP from the TE model due to uncertainties in primary measurements. This result sets a lower bound on the error bars of the TE model predictions. This analysis highlights the primary measurements that merit further development to reduce the uncertainty associated with their use in TE models. While we develop and apply this mathematical framework to a specific biorefinery scenario here, this analysis can be readily adapted to other types of biorefining processes and provides a general framework for propagating uncertainty due to analytical measurements through a TE model.