gebhart/patrepeval huggingface dataset:
Optimal Checkpointing of Real-Time Tasks (1987)

Analytical models for the design and evaluation of checkpointing of real-time tasks are developed. First, the execution of a real-time task is modeled under a common assumption of perfect coverage of on-line detection mechanisms (which is termed a basic model). Then, the model is generalized (to an extended model) to include more realistic cases, i.e., imperfect coverages of on-line detection mechanisms and acceptance tests. Finally, we determine an optimal placement of checkpoints to minimize the mean task execution time while the probability of an unreliable result (or lack of confidence) is kept below a specified level. In the basic model, it is shown that equidistant intercheckpoint intervals are optimal, whereas this is not necessarily true in the extended model. An algorithm for calculating the optimal number of checkpoints and intercheckpoint intervals is presented with some numerical examples for the extended model.
Paper No P36: Optimization of H2O Annealing for High‐Performance Low‐Temperature Solution‐Processed Oxide Thin‐Film Transistors (2013)

Abstract We fabricated 350°C low temperature solution‐processed zinc tin oxide thin film transistors by employing H 2 O wet annealing, which is considerably lower than widely used 500°C. We have optimized 350°C H 2 O wet annealing condition to achieve good electrical characteristics such as threshold voltage and saturation mobility.
Study of AlGaN/GaN HEMT degradation through TCAD simulations (2014)

This paper studies, through Three-Dimensional (3D) TCAD simulations, the formation of gate edge pits on the drain-side of GaN high electron mobility transistors (HEMTs) under electrical stress conditions. These pits are believed to be formed due to electrochemical reactions. The simulations predict that holes, which are necessary to initiate the electrochemical reaction but rare under regular HEMT operating conditions, can be generated through trap-assisted, band-to-band tunneling (B2B TAT). The impact of the electrical behavior of the pit (insulator or metal) on the output characteristics (I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">D</sub> -V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">D</sub> ) of the HEMTs were also studied. Insulator-type pits degrade the ON-resistance, R <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">D</sub> , while metal-types do not. At medium V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">D</sub> , both types of pit degrade I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">D</sub> , which will be recovered at higher V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">D</sub> . But metal-type requires larger V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">D</sub> to restore the I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">D</sub> . As the pits grow, the hole generation rate first increases (more with metal pit), then decrease after the pit-to-width ratio exceeds 20%.
Noise-Driven Stem Cell and Progenitor Population Dynamics (2008)

Consequently, state-specific noise modulation by external signals can be instrumental in controlling stem cell and progenitor population dynamics. We propose follow-up experiments for quantifying the imprinting influence of the environment on cellular noise regulation.
Identification of RP-6685, an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Polθ (2022)

DNA polymerase theta (Polθ) is an attractive synthetic lethal target for drug discovery, predicted to be efficacious against breast and ovarian cancers harboring BRCA-mutant alleles. Here, we describe our hit-to-lead efforts in search of a selective inhibitor of human Polθ (encoded by POLQ). A high-throughput screening campaign of 350,000 compounds identified an 11 micromolar hit, giving rise to the N2-substituted fused pyrazolo series, which was validated by biophysical methods. Structure-based drug design efforts along with optimization of cellular potency and ADME ultimately led to the identification of <b>RP-6685</b>: a potent, selective, and orally bioavailable Polθ inhibitor that showed in vivo efficacy in an HCT116 BRCA2<sup>-/-</sup> mouse tumor xenograft model.
Thermal Response to Simulated Lightning Currents on Stitched Composite Aircraft Structures (2016)

Integrally stitched composite structures have attracted significant interest for enhancing the structural integrity of aircraft. One recently developed stitched composite technology is the Pultruded Rod Stitched Efficient Unitized Structure (PRSEUS) concept. While PRSEUS structures offer a high structural performanceto- weight ratio over traditional stiffened panels and sandwich panels, their thermal response is not well understood. The through-thickness stitching of PRSEUS panels provides a barrier to delamination initiation and growth. Therefore, the thermal and mechanical damage in the PRSEUS panel may be profoundly different than for traditional (unstitched) laminated structures. In this study, nonlinear transient coupled thermal-electrical finite element (FE) analyses and subsequent heat transfer analyses were performed to characterize the thermal response of a PRSEUS panel subjected to a simulated transient high electrical current waveform consistent with lightning strikes. Temperature dependent-material properties of each structural sub-component (i.e., foam core, rod, stringer, frames, and exterior skin) were employed to predict the electrical current and temperature distributions in the PRSEUS panel. Several special-purpose user subroutines were developed i) to simulate the standard lightning current waveform, ii) to predict the temperature distribution associated with high electrical currents, and iii) to update material properties based on temperature-time history. The objective of this study is to characterize the potential thermal damage in a PRSEUS panel exposed to simulated high current waveforms as well as to probe the effect of stitching on the through-the-thickness electrical and heat conduction.
Building Bridges Between Researchers and Practitioners: A Collaborative Approach to Research in Performance Excellence (2008)

This article describes a collaborative approach initiated by the Monfort Institute at the University of Northern Colorado to engage high-level practitioners of perform- ance excellence and academic researchers to: a) identify the external and internal dilemmas facing practition- ers in high-performing organizations; b) develop a purposeful research agenda that addresses both the needs and interests of practitioners and researchers; and c) develop a concept of operations to address the research agenda. High-performing organizations face many external pressures from customers, investors, suppliers and partners, and the public. In addition, they face internal challenges including leadership and work force turnover, cultural challenges, and limited understanding of the continuous refinement and inte- gration of management systems at the upper levels of the Malcolm Baldrige National Quality Award (MBNQA) scoring scale. This initiative resulted in a viable research agenda of value to practitioners and researchers to better understand organizational performance excellence and improvement approaches and expand research efforts in quality management. Several projects are currently in process through the Monfort Institute, and plans for continued collaboration have been developed.
Supplementary Data from Thrombin Signaling Promotes Pancreatic Adenocarcinoma through PAR-1–Dependent Immune Evasion (2023)

&lt;p&gt;Table of differentially expressed genes from RNA-seq analysis of in vitro stimulation of KPC2 cells with and without thrombin.&lt;/p&gt;
Formulation of Seawater Flow Exergy Using Accurate Thermodynamic Data (2010)

Seawater is a complex electrolyte solution of water and salts with sodium chloride as the major constituent. However, the thermodynamic properties of seawater are considerably different from those of aqueous sodium chloride solution. In the literature, exergy analyses of seawater desalination systems have sometimes modeled seawater by sodium chloride solutions of equivalent salt content or salinity; however, such matching does not bring all important properties of the two solutions into agreement. Furthermore, some published studies attempt to represent sodium chloride solutions as a specific model for an ideal mixture of liquid water and solid sodium chloride, which is shown to have serious shortcomings. In this paper, the most up-to-date thermodynamic properties of seawater are compared with those of aqueous sodium chloride solution as well as the ideal mixture model. The flow exergy is calculated using various models and the results are compared. In addition, the minimum work required to desalinate a unit mass of fresh water from seawater of varying salinity is calculated using these models. The flow exergy calculated using the ideal mixture model in question is about 50% less than that of seawater. Accordingly, the minimum desalination work is underpredicted by about 50% when calculating it using that ideal mixture model. This consequently shows that exergy analysis and the second law efficiency calculations performed using the ideal mixture model is comparatively far from the actual values.
Bias dependence of spin transfer torque in Co2MnSi Heusler alloy based magnetic tunnel junctions (2017)

Heusler compounds are of interest as electrode materials for use in magnetic tunnel junctions (MTJs) due to their half metallic character, which leads to 100% spin polarization and high tunneling magnetoresistance. Most work to date has focused on the improvements to tunneling magnetoresistance that can stem from the use of Heusler electrodes, while there is much less work investigating the influence of Heusler electrodes on the spin transfer torque properties of MTJs. Here, we investigate the bias dependence of the anti-damping like and field-like spin transfer torque components in both symmetric (Co2MnSi/MgO/Co2MnSi) and asymmetric (Co2MnSi/MgO/CoFe) structure Heusler based MTJs using spin transfer torque ferromagnetic resonance. We find that while the damping like torque is linear with respect to bias for both MTJ structures, the asymmetric MTJ structure has an additional linear component to the ordinarily quadratic field like torque bias dependence and that these results can be accounted for by a free electron tunneling model. Furthermore, our results suggest that the low damping and low saturation magnetization properties of Heusler alloys are more likely to lead significant improvements to spin torque switching efficiency rather than their half metallic character.
Polymer optical interconnect technology (POINT) optoelectronic packaging and interconnect for board and backplane applications (2002)

The Polymer Optical interconnect Technology (POINT) is a collaborative program among GE, Honeywell, AMP, AlliedSignal, Columbia University and University of California at San Diego (UCSD), sponsored by ARPA, in developing affordable optoelectronic packaging and interconnect technologies for board- and backplane-level optical interconnect applications. The POINT program leverages on the existing electronic design, processing, fabrication and MCM packaging technologies to optoelectronic packaging. The POINT program also incorporates several state-of-the-art optoelectronic technologies that include: high speed VCSEL for multi-channel data transmission; flexible optical polymer waveguides and low-loss polymers for board and backplane interconnects; low-cost diffractive optical elements (DOE) for board-to-backplane interconnect; and use of molded MT-type connectors to reduce weight and size. In addition, to further reduce design and fabrication cycle times, CAD tools for multimode optical waveguide modelling, and for mechanical modelling of optoelectronic packaging will be employed to aid the technology development.
A Self-Service Approach to Scalable Service Deployment (2006)

We describe a system that enables services to scale to large numbers of clients, without the addition of new server resources and without sacrificing service consistency. Our system best supports services that can be decomposed into service objects that are typically accessed individually. Scalability is achieved by migrating objects and outsourcing operation processing to the clients themselves. We present novel algorithms for ensuring consistency of the service and for recovering objects if a client disconnects and leaves the latest versions of objects unreachable. Our system outperforms a centralized service implementation when object state (and thus object migration cost) is small, and when operations are compute-intensive (thus taking advantage of client processing power). In addition, a client executing its own operations enables applications in which the client is unwilling to send its operations elsewhere for processing, due to privacy concerns. We demonstrate these advantages through the evaluation of a wide-area network traffic classification service built using our system. 1
Development of Beam-tilt Angle Calibration Technique for CD-SEM (2005)

測長SEMのビームチルト観察機能におけるチルト角の高精度計測手法を立案. キャリブレータとして二方向のチルト角を同時推定可能なピラミッド型異方性エッチングサンプルを使用. 画像の歪み補正を伴ってサンプルの画像上での幾何変形を推定する画像処理と, その幾何変形からチルト角を求める推定エンジンとを開発し, 半導体プロセスモニタにおいて十分な推定再現性を達成.
ChemInform Abstract: New Preparation of Pyridines from Enamino Nitriles. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Abstract 301: Targeting Mixed Lineage Kinases in pathological cardiac fibroblast activation and intercellular communication (2013)

Cardiovascular disease (CVD) and the final clinical iteration, heart failure (HF), affect more than 82 million Americans yearly, affects &gt;5.7 million). Although the cardiac myocyte has long been the focus of cardiac cellular research, our lab and others have demonstrated that pathological activation of cardiac fibroblasts (CF) after onset of disease or cardiac injury is also a key player in HF pathogenesis. Pathologic activation of CFs causes a release of various paracrine and autocrine factors that target cardiomyocytes (CM), local inflammatory cells and the CFs themselves. Elucidating the mechanisms involved in pathological ‘support cell (CF)’- ‘functional cell (CM)’ communication may hold therapeutic promise. Mixed lineage kinase 3 (MLK3) is a stress activated mitogen-activated protein kinase kinase kinase (MAPKKK) involved in pro-apoptotic pathways. Inhibition of MLK3 in HAND results in the attenuation of microglial cell activation, preservation of neuronal function and synaptic structures. The parity between microglia-neuron communication and CF-CM communication and the effects of pathological activation on the respective support cells for each tissue type suggested a role for MLK3 in aberrant CF-CM cross-talk associated with the development and progression of HF. Preliminary data in mice subjected to a pharmacological model of HF (chronic isoproterenol) that were treated with a small molecule inhibitor (URMC-099) of MLK3 demonstrated a reduction in the development of myocardial fibrosis compared to vehicle treated animals. Additionally, small molecule MLK3 inhibition attenuated the development of myocardial hypertrophy as measured by heart weight: body weight and heart weight: tibia length ratios. Studies in cultured neonatal rat ventricular fibroblasts (NRVF) demonstrated that small molecule MLK3 inhibition attenuated CF activation and transition to a myofibroblast phenotype, including reductions of pathologic CF markers such as α-SMA, IL-6, IL-1β, and others. Our data demonstrate that MLK3 plays an important role in pathologic CF-CM communication and myocardial hypertrophy, and suggest that small molecule inhibition of MLK3 holds therapeutic promise for HF.
Comparative study of a Hybrid Model for network traffic identification and its optimization using Firefly Algorithm (2013)

Considerable effort has been made by researchers in the area of network traffic classification, since the Internet grows exponentially in both traffic volume and number of protocols and applications. The task of traffic identification is a complex task due to the constantly changing Internet and an increase in encrypted data. There are several methods for classifying network traffic such as port-based and Deep Packet Inspection (DPI), but they are not effective since many applications use random ports and the payload could be encrypted. This paper proposes an Optimized Hybrid Model (OHM) that makes use of a rule-based model (Apriori) along with a self-organizing map (SOM) model to tackle the problem of traffic classification without making use of the payload or ports. The proposed method also allows the generation of association rules for new unknown applications and further labeling by experts. Besides that, a optimizer called Firefly Algorithm was also used to enhance the results by optimizing both Apriori and SOM parameters and a comparative study was performed on both optimized and non-optimized models. The OHM showed to be superior to a non-optimized model for both eMule and Skype applications, reaching levels superior to 94% for correctness rate. The OHM was also validated against another model based on computational intelligence, named Realtime, and the OHM proposed in this work presented better results when tested in real time.
Copper-oxide reduction for low-temperature wafer bonding (2012)

Silicon wafers with a 500 nm sputtered Cu layer were successfully bonded at low temperatures of 175°C for 30 min in forming gas. Auger electron spectroscopy (AES) and transmission electron microscopy (TEM) were used for oxide detection and microstructure imaging.
IN VIVO HUMAN BONE FORMATION USING BMP-2 ENCAPSULATED POLYMER SCAFFOLDS (2005)

The use of designer scaffolds to deliver biologically active osteogenic growth factors such as recombinant human bone morphogenetic protein-2 (rhBMP-2) to the sites of tissue regeneration in for example orthopaedics, has tremendous therapeutic implications. The aims of this study were to generate biomimetic biodegradable porous osteogenic scaffolds using a supercritical fluid process to encapsulate rhBMP-2, and to examine the ability of the scaffolds to promote human osteoprogenitor differentiation and bone formation in vitro and in vivo. The rhBMP-2 encapsulated in Poly(-lactic acid) (PLA) scaffolds (100ng/mg PLA) were generated using an innovative supercritical fluid mixing method. The bioactivity of rhBMP-2 encapsulated PLA scaffolds were confirmed by induction of the C2C12 promyoblast cell line into the osteogenic lineage as detected by alkaline phosphatase expression. No induction of alkaline phosphatase-positive cells was observed using blank scaffolds. BMP-2 released from encapsulated constructs promoted adhesion, migration, expansion and differentiation of human osteoprogenitor cells on 3-D scaffolds. Enhanced matrix synthesis and cell differentiation on growth factor encapsulated scaffolds was observed following culture of human osteoprogenitors on explants of chick femoral bone wedge defects in an ex vivo model of bone formation developed using the chick chorioallantoic membrane model. In vivo studies using diffusion chamber implantation and subcutaneous implantation of human osteoprogenitors on rhBMP-2 encapsulated scaffolds showed morphologic evidence of new bone matrix and cartilage formation in athymic mice as assessed by x-ray analysis, immunocytochemistry and birefringence. These studies provide evidence of controlled release of BMP-2 from biodegradable polymer scaffolds initiating new bone formation in vivo. The generation of 3-D biomimetic structures incorporating osteoinductive factors such as BMP-2 indicates their potential for de novo bone formation that exploits cell-matrix interactions and, significantly, realistic delivery protocols for growth factors in musculo-skeletal tissue engineering.
Synthesis and chemistry of 9-homonoradamantane (tricyclo[3.3.2.03,7]decane) (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and chemistry of 9-homonoradamantane (tricyclo[3.3.2.03,7]decane)Zdenko Majerski, Stjepan Djigas, and Vladimir VinkovicCite this: J. Org. Chem. 1979, 44, 23, 4064–4069Publication Date (Print):November 1, 1979Publication History Published online1 May 2002Published inissue 1 November 1979https://pubs.acs.org/doi/10.1021/jo01337a009https://doi.org/10.1021/jo01337a009research-articleACS PublicationsRequest reuse permissionsArticle Views228Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Temperature dependence of microwave voltage emission associated to spin-transfer induced vortex oscillation in magnetic tunnel junction (2012)

The temperature dependence of a vortex-based nano-oscillator induced by spin transfer torque (STVO) in magnetic tunnel junctions (MTJ) is considered. We obtain emitted signals with large output power and good signal coherence. Due to the reduced non-linearities compared to the uniform magnetization case, we first observe a linear decrease of linewidth with decreasing temperature. However, this expected behavior no longer applies at lower temperature and a bottom limit of the linewidth is measured.