gebhart/patrepeval huggingface dataset:
5 Tdots/in2 bit patterned media fabricated by a directed self-assembly mask (2013)

FePt bit patterned media (BPM) was fabricated with a self-assembled polymer mask with a feature size of 12 nm pitch (equivalent to 5 Tdots/in <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ). A 3.5 nm FePt film with high c-axis crystal orientation was prepared for the magnetic recording layer. A solvent vapor annealing process was applied for obtaining uniform directed self-assembling of polystyrene (PS)-polydimethylsiloxane (PDMS) diblock copolymer pattern. Pattern transfer from a polymer mask to FePt layer was achieved by employing a carbon hard mask. In spite of excellent magnetic characteristics of FePt layer, the fabricated FePt BPM showed small coercivity ( <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">H</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</sub> ) of 6 kOe and large switching field distribution (SFD) of 21%. These results are due to the etching damage of FePt dots. Disordering of FePt L1 <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> phase by the etching damage reduced magnetic anisotropy energy ( <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">K</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">u</sub> ). The damaged portion became a nucleus of the magnetization reversal and reduced <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">H</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</sub> . Distribution of the damaged volume and the extent of the <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">K</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">u</sub> reduction contributed to large SFD. This model is supported by the experimental data of magnetic field angle dependence of switching field. The result suggests the domain wall motion type of magnetization reversal mode, where the domain wall is created at the interface between the damaged portion and the internal high- <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">K</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">u</sub> region.
Effects of Previous or Synchronous Non-Muscle Invasive Bladder Cancer on Clinical Results after Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma: A Multi-Institutional Study. (2015)

In patients with UTUC, previous or synchronous NMIBC was significantly associated with an increased risk of cancer recurrences in the bladder after radical nephroureterectomy. The present find­ings suggest that a close monitoring should be required for the patients with previous or concomitant NMIBC.
Effect of NSAIDs on Na+/H+ exchanger activity in rat colonic crypts (2013)

Nonsteroidal anti-inflammatory drugs (NSAIDs; 1) are widely recommended for several acute and chronic conditions. For example, both indomethacin and aspirin are taken for pain relief. Aspirin is also used for prevention of myocardial infarction, and indomethacin can be administered orally or as a suppository for patients with rheumatoid disease and other chronic inflammatory states. However, use of NSAIDs can cause damage to the mucosal barrier surrounding the gastrointestinal (GI) tract, increasing the risk of ulcer formation. While microencapsulation of NSAIDs has been shown to reduce upper GI injury, sustained release in the lower GI tract and colon may cause epithelial erosion due to increased acidification. The use of suppositories has also been linked to rectal and lower GI bleeding. In this study, we investigated the role of NSAIDs aspirin and indomethacin on Na⁺/H⁺ exchanger (NHE) activity in rat colonic crypts. By comparing average rates of pH recovery between control and NSAID perfusion runs, we were able to determine that both aspirin and indomethacin increase hydrogen extrusion into the colonic lumen. Through treatment with 5-ethylisopropyl amiloride (EIPA), amiloride, and zoniporide dihydrochloride, we further demonstrated that indomethacin specifically enhances proton excretion through regulation of apical NHE-3 and NHE-2 and to a lesser extent on basolateral NHE-1 and NHE-4. Our results suggest that clinical exposure to NSAIDs may affect colonic tissue at the site of selected NHE isoforms, resulting in modulation of transport and barrier function.
Possibilities for a Silicon Model of the Cochlea (2000)

Abstract The purpose of this study is to resolve questions regarding the fundamental physical behavior of the cochlea of the inner ear. We seek a convergence of measurement and computation on physical models that capture essential features. Since there are unique features in the performance of the cochlea, the physical models could lead to device development. A much longer-term goal is a device for the assistance of hearing impaired individuals. The cochlea can be modeled as a tube of fluid divided by a partition, a portion of which is elastic and called the basilar membrane (BM). In preliminary work, the cochlear partition is constructed on a silicon wafer using current capabilities for micro-machining. The silicon nitride partition is inserted into a chamber of Plexiglas which is filled with solute and has a “stapes” for acoustic input and a “round window”. The silicon BM has the correct length, but is wider and isotropic. The measurements, supported by calculations, show that the deviation from the actual structure has a detrimental effect on the sharpness of the spatial distribution of the response for a fixed input frequency. Possibilities for improved models and for an active non-linear model with distributed sensors and actuators are discussed.
Change in the morphology of hydroxyapatite nanocrystals in the presence of bioaffinitive polymeric species under the application of electrical field (2006)

Application of the external electrical field during the precipitation of hydroxyapatite (HAP) nanoparticles in the presence of bioaffinitive polymeric species, individual crystallites as well as their coherent agglomerates increases their anisotropy with the increasing aspect ratio of the crystallites, Lc/La or of aggregated particles, dc/da. The tendency was quite similar when we change the polymeric species between gelatin (GLT) and sodium salt of hyaluronic acid (HYA), although the extent of change is larger for GLT as compared to HYA, presumably due to stronger polymer–HAP interaction in case of HYA. External electrical field often causes severe agglomeration to fairly isotropic particles with substantial loss of the HAP crystallinity. This might be attributed to the strong ionic interaction between and COO− group of HYA, which is not the case with GLT.
Increased Exciton Delocalization of Polymer upon Blending with Fullerene (2018)

Interfaces between donor and acceptor in a polymer solar cell play a crucial role in exciton dissociation and charge photogeneration. While the importance of charge transfer (CT) excitons for free carrier generation is intensively studied, the effect of blending on the nature of the polymer excitons in relation to the blend nanomorphology remains largely unexplored. In this work, electroabsorption (EA) spectroscopy is used to study the excited-state polarizability of polymer excitons in several polymer:fullerene blend systems, and it is found that excited-state polarizability of polymer excitons in the blends is a strong function of blend nanomorphology. The increase in excited-state polarizability with decreased domain size indicates that intermixing of states at the interface between the donor polymers and fullerene increases the exciton delocalization, resulting in an increase in exciton dissociation efficiency. This conclusion is further supported by transient absorption spectroscopy and time-resolved photoluminescence measurements, along with the results from time-dependent density functional theory calculations. These findings indicate that polymer excited-state polarizability is a key parameter for efficient free carrier generation and should be considered in the design and development of high-performance polymer solar cells.
Interactive Authoring of Logical Forms for Multilingual Generation (2005)

We present an authoring system for logical forms encoded as conceptual graphs (CG). The system belongs to the family of WYSIWYM (What You See Is What You Mean) text generation systems: logical forms are entered interactively and the corresponding linguistic realization of the expressions is generated in several languages. The system maintains a model of the discourse context corresponding to the authored documents. The system helps users author documents formulated in the CG format. In a first stage, a domainspecific ontology is acquired by learning from example texts in the domain. The ontology acquisition module builds a typed hierarchy of concepts and relations derived from the WordNet and Verbnet. The user can then edit a specific document, by entering utterances in sequence, and maintaining a representation of the context. While the user enters data, the system performs the standard steps of text generation on the basis of the authored logical forms: reference planning, aggregation, lexical choice and syntactic realization – in several languages (we have implemented English and Hebrew- and are exploring an implementation using the Bliss graphical language). The feedback in natural language is produced in real-time for every single modification performed by the author. We perform a cost-benefit analysis of the application of NLG techniques in the context of authoring cooking recipes in English and Hebrew. By combining existing large-scale knowledge resources (WordNet, Verbnet, the SURGE and HUGG realization grammars) and techniques from modern integrated software development environment (such as the Eclipse IDE), we obtain an efficient tool for the generation of logical forms, in domains where content is not available in the form of databases.
Severe childhood speech disorder (2020)

We identify the likely genetic etiology in 11 patients with CAS and implicate 9 genes for the first time. We find that CAS is often a sporadic monogenic disorder, and highly genetically heterogeneous. Highly penetrant variants implicate shared pathways in broad transcriptional regulation, highlighting the key role of transcriptional regulation in normal speech development. CAS is a distinctive, socially debilitating clinical disorder, and understanding its molecular basis is the first step towards identifying precision medicine approaches.
Tolerance of T‐independent xeno‐antibody responses in the hamster‐to‐rat xenotransplantation model is species‐restricted but not tissue‐specific (2000)

Control of early acute xenograft rejection xenoreactions in the hamster-to-Lewis rat xenotransplantation model with cyclosporine (CsA) and leflunomide subdues early T-independent xenoreactivity and uncovers a late immune response that can be controlled by CsA alone. We had attributed this acquired responsiveness to CsA to the induction of tolerance of T-independent xeno-antibody responses in the recipient and recently reported that this tolerance is species-specific. Here we have further characterized the specificity and nature of this tolerant state. Lewis rats transplanted with either hearts, skin, kidney or spleen/pancreas from Golden Syrian hamsters were treated with leflunomide (5 mg/kg/day by gavage) for 14-21 days and CsA (20 mg/kg/day by gavage) continuously from the day of transplant. Some Lewis rats received a second graft of hearts or skin from Golden Syrian hamsters (day 21-30 after first transplant), and a third heart graft from Balb/c mice (day 60 after the first transplant). Serum was harvested and the titers of xenoreactive antibodies were quantified by flow cytometry. All grafts were harvested at the end of each experiment and examined by histological and immunohistochemical methods. The combination of CsA and leflunomide was able to completely inhibit the rejection of kidney, spleen and pancreas xenografts in this hamster-to-rat xenotransplantation model. In addition, only a transient treatment with leflunomide was necessary, and long-term graft survival could subsequently be maintained by CsA alone. Histological examination of these grafts at > 80 days post-transplantation indicated minimal signs of rejection. These immediately vascularized organs induced T-independent B-cell tolerance, so that second grafts of hamster hearts and skin could be maintained with CsA alone. Under the same immunosuppressive regimen, only four out of nine Lewis rats exhibited long-term hamster skin survival, probably reflecting the increased immunogenicity of the skin compared with other vascularized grafts. Nonetheless, all rats that did not reject the hamster skin graft also did not reject the hamster heart while on CsA alone. Finally, we demonstrate that the tolerant state could be maintained for up to 30 days in the absence of xenograft. The vigorous T-independent antibody response that mediates acute xenograft rejection in the hamster-to-rat model can be tolerized by the immunosuppressive regimen of CsA and leflunomide. The lack of organ specificity for the induction of this tolerance suggests that the xenoantigens inducing tolerance may be common endothelial cell antigens. Finally, the presence of the xenograft has been previously shown to be critical for the induction of T-independent B-cell tolerance, however, the tolerant state is relatively stable and persists after the removal of the xenograft.
Wafer-scale silicon nanopillars and nanocones by Langmuir–Blodgett assembly and etching (2008)

We have developed a method combining Langmuir–Blodgett assembly and reactive ion etching to fabricate nanopillars with uniform coverage over an entire 4 inch wafer. We demonstrated precise control over the diameter and separation between the nanopillars ranging from 60 to 600 nm. We can also change the shape of the pillars from having vertical to tapered sidewalls with sharp tips exhibiting a radius of curvature of 5 nm. This method opens up many possible opportunities in nanoimprinting, solar cells, batteries, and scanning probes.
Effect of electrode surface roughness and dielectric coating on breakdown characteristics of high pressure CO2 and N2 in a quasi-uniform electric field (2008)

SF <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sub> gas has excellent dielectric strength and interrupting capability and is used in various applications such as gas insulated switchgear (GIS) in substations. However, since SF <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sub> has a high global warming potential (GWP), it is imperative to reduce its use and develop recovery technology for its reuse. This paper examined the potential of alternative insulating gases for GIS, determining experimentally the ac and lightning impulse breakdown characteristics of CO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> and N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> gases, which have little environmental impact, in a quasi-uniform electric field. The effect of electrode surface roughness is greater in N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> than in CO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> . The impulse ratio in a quasi-uniform electric field was smaller in N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> than in CO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> at low pressure, but this reversed when the pressure reached 1.2 MPa. The dielectric strength of an electrode with a dielectric coating was approximately equal to that of a specular-finish bare electrode in either CO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> or N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> when an ac voltage was applied. When lightning impulse voltage was applied, a significant improvement of dielectric strength was observed if a dielectric coating was applied to the electrode considered to be the initial electron source.
A Simple Protocol Whose Proof Isn't (1985)

Aho, Ullman, and Yannakakis have proposed a set of protocols that ensure reliable transmission of data across an error-prone channel. They have obtained lower bounds on the complexity required of the protocols to assure reliability for different classes of errors. They specify these protocols with finite-state machines. Although the protocol machines have only a small number of states, they are nontrivial to prove correct. In this paper we present proofs of one of these protocols using the finite-state-machine approach and the abstract-program approach. We also show that the abstract-program approach gives special insight into the operation of the protocol.
Creation of strong pinning sites by x-ray irradiation for Gd1Ba2Cu3O7−x superconducting thin films (1990)

A large enhancement of critical current density with the small rate of flux creep was realized by x-ray irradiation before the oxygen annealing for Gd1Ba2Cu3O7−x superconducting thin films. The significantly increased magnetization showed both the temperature independence and the small magnetic relaxation. The activation energy estimated by the flux creep model increased from 0.1 to 0.25 eV with the x-ray irradiation treatment.
Generation of cryopreserved macrophages from normal and genetically engineered human pluripotent stem cells for disease modelling (2021)

Macrophages are innate immune cells that play critical roles in tissue homeostasis, inflammation, and immune oncology. Macrophages differentiated from human induced pluripotent stem cells (iPSCs) overcome many limitations of using peripheral blood derived macrophages. The ability to scale up and cryopreserve a large amount of end stage macrophages from single clonal iPSCs from normal and disease specific donors offers a unique opportunity for genomic analysis and drug screening. The present study describes the step wise generation and characterization of macrophages from iPSCs using a defined serum free method amenable to scale up to generate a large batch of pure end stage cryopreservable macrophages expressing CD68, CD33, CD11c, CD11b, CD1a, HLA-DR, CD86, CD64, CD80, CD206, CD169, CD47, HLA-ABC, and CX3CR. The end stage macrophages pre and post cryopreservation retain purity, morphology, responsiveness to stimuli and display robust phagocytic function coming right out of cryopreservation. The same differentiation process was used to generate end stage macrophages from isogenic iPSCs engineered to mimic mutations associated with Parkinson's disease (SNCA A53T), neuronal ceroid lipofuscinosis (GRN2/GRN R493X), and Rett syndrome (MECP2-Knockout). End stage macrophages from isogenic engineered clones displayed differential macrophage-specific purity markers, phagocytic function, and response to specific stimuli. Thus, generating a panel of functional, physiologically relevant iPSC-derived macrophages can potentially facilitate the understanding of neural inflammatory responses associated with neurodegeneration.
Supplementary document for Imaging from the visible to the longwave infrared wavelengths via an inverse-designed flat lens - 5267513.pdf (2021)

Supplementary information
Divergent Subunit Interactions among Fungal mRNA 5′-Capping Machineries (2002)

The Saccharomyces cerevisiae mRNA capping enzyme consists of two subunits: an RNA 5'-triphosphatase (RTPase) and GTP::mRNA guanylyltransferase (GTase). The GTase subunit (Ceg1) binds to the phosphorylated carboxyl-terminal domain of the largest subunit (CTD-P) of RNA polymerase II (pol II), coupling capping with transcription. Ceg1 bound to the CTD-P is inactive unless allosterically activated by interaction with the RTPase subunit (Cet1). For purposes of comparison, we characterize here the related GTases and RTPases from the yeasts Schizosaccharomyces pombe and Candida albicans. Surprisingly, the S. pombe capping enzyme subunits do not interact with each other. Both can independently interact with CTD-P of pol II, and the GTase is not repressed by CTD-P binding. The S. pombe RTPase gene (pct1+) is essential for viability. Pct1 can replace the S. cerevisiae RTPase when GTase activity is supplied by the S. pombe or mouse enzymes but not by the S. cerevisiae GTase. The C. albicans capping enzyme subunits do interact with each other. However, this interaction is not essential in vivo. Our results reveal an unexpected diversity among the fungal capping machineries.
Video transport in wireless ATM (2002)

Wireless ATM LANs have the potential to support multi-Mb/s bandwidths to mobile users with guaranteed quality of service. However, the lossy nature of the wireless medium will pose problems for loss-sensitive applications. Techniques to minimize the effect of these losses will therefore be required. In this paper, we examine the use of combined source and channel coding for MPEG video transport in a wireless ATM environment. Although forward error correction (FEC) provides protection against channel bit errors, the bandwidth overhead can become a significant drawback in a fixed bandwidth scenario. Additional protection against losses can be realized by using two-layer video coding. In this work, we compare the performance of a 1-layer main profile and 2-layer data partitioning and SNR scalable MPEG-2 encoders in a system with random channel errors and forward error correction. The results indicate that if the channel bit error rate is known an optimum FEC level can be chosen for the 1-layer case; However, at this fixed FEC level, if a critical bit error rate is exceeded then video quality degrades dramatically. The 2-layer cases appear to lead to more graceful degradation in quality at this critical bit error rates. In particular, SNR scalability may lead to better video quality over a larger range of bit error rates than a 1-layer approach.
Stabilization and Topical Skin Delivery of Framework Nucleic Acids using Ionic Liquids (2020)

Abstract Framework nucleic acids (FNAs) are emerging nanocarriers owing to their inherent biocompatibility, precise assembly, and inherent compatibility with NA therapeutics. Topical administration of FNAs promises gene therapy of skin diseases. However, their stabilization and delivery efficiency across the stratum corneum remain a challenge. This work reports the use of choline carboxylic acid‐based ionic liquids to simultaneously address these two hurdles. First, the FNAs are assembled and solvated, and their structural stability is confirmed using fluorescence spectroscopy, dynamic light scattering, and gel electrophoresis. Of the six formulations tested, choline octenoate exhibits the best stabilizing properties at room temperature. Additionally, this formulation successfully transports FNAs into the lower dermis region in intact, ex vivo porcine skin.