gebhart/patrepeval huggingface dataset:
Supersonic Retropulsion Surface Preparation of Carbon Fiber Reinforced Epoxy Composites for Adhesive Bonding (2013)

Surface preparation is widely recognized as a key step to producing robust and predictable bonds in a precise and reproducible manner. Standard surface preparation techniques, including grit blasting, manual abrasion, and peel ply, can lack precision and reproducibility, which can lead to variation in surface properties and subsequent bonding performance. The use of a laser to ablate composite surface resin can provide an efficient, precise, and reproducible means of preparing composite surfaces for adhesive bonding. Advantages include elimination of physical waste (i.e., grit media and sacrificial peel ply layers that ultimately require disposal), reduction in process variability due to increased precision (e.g. increased reproducibility), and automation of surface preparation, all of which improve reliability and process control. This paper describes a Nd:YAG laser surface preparation technique for composite substrates and the mechanical performance and failure modes of bonded laminates thus prepared. Additionally, bonded specimens were aged in a hot, wet environment for approximately one year and subsequently mechanically tested. The results of a one year hygrothermal aging study will be presented.
Genome-wide identification of Isw2 chromatin-remodeling targets by localization of a catalytically inactive mutant (2005)

Isw2 ATP-dependent chromatin-remodeling activity is targeted to early meiotic and MATa-specific gene promoters in Saccharomyces cerevisiae. Unexpectedly, preferential cross-linking of wild-type Isw2p was not detected at these loci. Instead, the catalytically inactive Isw2p-K215R mutant is enriched at Isw2 targets, suggesting that Isw2p-K215R, but not wild-type Isw2p, is a sensitive chromatin immunoprecipitation (ChIP) reagent for marking sites of Isw2 activity in vivo. Genome-wide ChIP analyses confirmed this conclusion and identified tRNA genes (tDNAs) as a new class of Isw2 targets. Loss of Isw2p disrupted the periodic pattern of Ty1 integration upstream of tDNAs, but did not affect transcription of tDNAs or the associated Ty1 retrotransposons. In addition to identifying new Isw2 targets, our localization studies have important implications for the mechanism of Isw2 association with chromatin in vivo. Target-specific enrichment of Isw2p-K215R, not wild-type Isw2p, suggests that Isw2 is recruited transiently to remodel chromatin structure at these sites. In contrast, we found no evidence for Isw2 function at sites preferentially enriched by wild-type Isw2p, leading to our proposal that wild-type Isw2p cross-linking reveals a scanning mode of the complex as it surveys the genome for its targets.
Monoclonal Antibodies for Bacterial Pathogens: Mechanisms of Action and Engineering Approaches for Enhanced Effector Functions (2022)

Monoclonal antibody (mAb) therapy has opened a new era in the pharmaceutical field, finding application in various areas of research, from cancer to infectious diseases. The IgG isoform is the most used therapeutic, given its long half-life, high serum abundance, and most importantly, the presence of the Fc domain, which can be easily engineered. In the infectious diseases field, there has been a rising interest in mAbs research to counteract the emerging crisis of antibiotic resistance in bacteria. Various pathogens are acquiring resistance mechanisms, inhibiting any chance of success of antibiotics, and thus may become critically untreatable in the near future. Therefore, mAbs represent a new treatment option which may complement or even replace antibiotics. However, very few antibacterial mAbs have succeeded clinical trials, and until now, only three mAbs have been approved by the FDA. These failures highlight the need of improving the efficacy of mAb therapeutic activity, which can also be achieved with Fc engineering. In the first part of this review, we will describe the mechanisms of action of mAbs against bacteria, while in the second part, we will discuss the recent advances in antibody engineering to increase efficacy of pre-existing anti-bacterial mAbs.
Animal Models of Cardiovascular Complications of Pregnancy (2022)

Cardiovascular complications of pregnancy have risen substantially over the past decades, and now account for the majority of pregnancy-induced maternal deaths, as well as having substantial long-term consequences on maternal cardiovascular health. The causes and pathophysiology of these complications remain poorly understood, and therapeutic options are limited. Preclinical models represent a crucial tool for understanding human disease. We review here advances made in preclinical models of cardiovascular complications of pregnancy, including preeclampsia and peripartum cardiomyopathy, with a focus on pathological mechanisms elicited by the models and on relevance to human disease.
Enhanced Paging Monitoring for 5G and Beyond 5G Networks (2022)

User experience, characterized by not only data rate and latency but also power consumption, is one of the major drivers for the success of 5G and Beyond-5G (B5G) networks. User Equipment (UE) power saving enhancements are at the forefront of ongoing discussions in 3GPP for next generation radio standards. Idle mode Discontinuous Reception (IDRX) is an important mechanism for UE’s power saving. However, IDRX in 5G/B5G networks is more challenging than in legacy networks. UE is required to measure Synchronization Signal Block(s) (SSBs) for Physical Downlink Shared Channel (PDSCH) and Physical Downlink Common Control Channel (PDCCH) reception in every paging occasion (PO) of IDRX cycle in 5G/B5G networks. Furthermore, PDSCH decoding is very sensitive to the time-frequency synchronization error and requires multiple SSB measurements before every PO. In this paper we present an Enhanced Paging Monitoring (EPM) for reducing the impediments on IDRX in 5G/B5G due to SSB measurements and related overheads. We also extend our EPM proposal by incorporating paging early indication. The proposed EPM can manifest up to 37% more power saving compared to existing system while considering multiple SSB measurements that are essential to 5G/B5G networks.
SiGe heterojunction Bipolar applications (2021)

This chapter deals with the collector current which peculiarities can arise due to heavy-doping effects in the layers and the double heterojunction at both base-emitter and base-collector diode. It then reviews theories describing DC- and AC-behaviour of the heterojunction bipolar transistor. Due to channeling effects during the phosphorous-implant of the emitter, the latter found a strong reduction of the collector current due to a parasitic barrier at the base edge of the base-collector junction. King mentioned in his pioneering paper of 1989 that, based on the temperature dependence of the ratio of the base current in the HBT to the collector current of the reference homojunction transistor, an important portion of the base current was caused by neutral base recombination. Surface passivation and more specifically perimeter passivation is not a difficult problem in classical Si-technology, since the thermal oxide of Si has excellent passivation properties.
Design Methodology for a SEAREV Wave Energy Converter (2007)

This article will begin by presenting two power take-off (PTO) technologies for the SEAREV wave energy converter (WEC) followed by the design methodology applied to electromagnetic generator cycles for the "all-electric" solution. We will describe the operating principle associated with the SEAREV WEC before discussing the two conversion technologies intended to transform wave energy into electricity. The types of systems are twofold: hydroelectric and all-electric. The strong coupling between the hydrodynamic, mechanical and electrical phenomena heavily influences the behavior of the recovery (PTO) system and leads to a complex system design that requires a full-scale modeling description. A unique design methodology for the all-electric conversion chain has been developed around several distinct control modes, including one featuring power leveling.
The interface screening model as origin of imprint in PbZrxTi1−xO3 thin films. I. Dopant, illumination, and bias dependence (2002)

Comprehensive imprint measurements on PbZrxTi1−xO3 (PZT) thin films were carried out. Different models, which were proposed in literature to explain imprint in ferroelectric thin films or a similar aging effect (internal bias) in ferroelectric bulk material, are reviewed. Discrepancies between the experimental results obtained on the PZT films in this work and the prediction of the literature models indicate that these models do not describe the dominant imprint mechanism in PZT thin films. Hence, in this work a model is proposed which suggests imprint to be caused by a strong electric field within a thin surface layer in which the ferroelectric polarization is smaller or even absent compared to the bulk of the film. With the proposed imprint model the influence of important experimental parameters like dopant, illumination, and bias dependence can be qualitatively explained.
Dendrimer end-terminal motif-dependent evasion of human complement and complement activation through IgM hitchhiking (2021)

Complement is an enzymatic humoral pattern-recognition defence system of the body. Non-specific deposition of blood biomolecules on nanomedicines triggers complement activation through the alternative pathway, but complement-triggering mechanisms of nanomaterials with dimensions comparable to or smaller than many globular blood proteins are unknown. Here we study this using a library of <6 nm poly(amido amine) dendrimers bearing different end-terminal functional groups. Dendrimers are not sensed by C1q and mannan-binding lectin, and hence do not trigger complement activation through these pattern-recognition molecules. While, pyrrolidone- and carboxylic acid-terminated dendrimers fully evade complement response, and independent of factor H modulation, binding of amine-terminated dendrimers to a subset of natural IgM glycoforms triggers complement activation through lectin pathway-IgM axis. These findings contribute to mechanistic understanding of complement surveillance of dendrimeric materials, and provide opportunities for dendrimer-driven engineering of complement-safe nanomedicines and medical devices.
Weldability of DOP-26 iridium alloy: Effects of welding gas and alloy composition (1992)

The DOP‐26 iridium alloy, containing 2000‐ to 4000‐ppm W, 30‐ to 90‐ppm Th, and 20‐ to 80‐ppm Al by weight, is used as a cladding material. The closure weld on the fueled clad is performed by gas‐tungsten‐arc (GTA) welding, which under certain conditions results in hot cracking of the fusion zone. The effects of variations in the chemical composition of the alloy and in the welding gas atmosphere on the welding behavior are evaluated using the Sigmajig test. In this test, sheet materials are welded in an argon atmosphere with measured levels of applied stress to determine a threshold stress for hot cracking. The threshold stress for cracking of DOP‐26 alloy increases by a factor of two as the thorium content is decreased from 94 to 37 ppm. There is no effect on threshold cracking stress for variations in oxygen content of the argon welding atmosphere from 10 to 2000 ppm or for variations in water vapor content from 10 to 1000 ppm.
Supplementary Methods, Supplementary Tables 1 - 11, and Supplementary Figures 1-9 from Characterization of a Novel FLT3 BiTE Molecule for the Treatment of Acute Myeloid Leukemia (2023)

&lt;p&gt;Supplementary Methods. Supplementary Table 1 - Key Resources Including Sources of Biological Samples, Antibodies, and Key Reagents. Supplementary Table 2 -Correlation of FLT3 Expression Levels With Disease Characteristics at Initial Diagnosis. Supplementary Table 3 - Summary of Human Nonimmune Tissues Positive for FLT3 mRNA and/or Protein Expression in At Least One Platform. Supplementary Table 4. Cerebellum FLT3 RNA Analysis. Supplementary Table 5 - Binding Affinities of Experimental FLT3 BiTE® Molecule and AMG 427. Supplementary Table 6 - Cell Line Characterization, Cytotoxicity, and T-Cell Activation (Human). Supplementary Table 7 - Cynomolgus Monkey Pharmacokinetics for Experimental FLT3 BiTE® Molecule. Supplementary Table 8 - Cynomolgus Monkey Pharmacokinetics for AMG 427. Supplementary Table 9 - Cynomolgus Monkey FLT3 Primer and Probe Sequences. Supplementary Table 10 - Patient Characteristics. Supplementary Table 11 - Mass Spectrometry Results. Supplementary Figure 1 - Additional flow cytometry expression analysis for acute myeloid leukemia (AML) and healthy donor (HD) bone marrow (BM). Supplementary Figure 2 - Analysis of FLT3 expression on normal human bone marrow. Supplementary Figure 3 - Analysis of FLT3 transcript and protein in cerebellum revealed truncated transcripts. Supplementary Figure 4 - In vitro characterization of FLT3 BiTE® molecules. Supplementary Figure 5 - Experimental FLT3 BiTE® molecule activity in vivo. Supplementary Figure 6 - FLT3 BiTE® molecule in vitro activity with cynomolgus monkey effector cells. Supplementary Figure 7 - FLT3 expression in cynomolgus monkey blood and bone marrow. Supplementary Figure 8 - AMG 427 pharmacodynamics in cynomolgus monkey. Supplementary Figure 9 - (A) Representative populations of T cells (CD2+) and AML cells (CD33+) over time from a responder (Patient 4; Figure 6A). (B) PD-1 expression on CD3+ cells from a T-cell-dependent cellular cytotoxicity (TDCC) of human pan T cells co-cultured 5:1 with MV4-11 cells for 48 hours assessed by flow cytometry.&lt;/p&gt;
Dual-frequency admittance property of two sections transmission-line and application (2016)

In this paper, an interesting dual-frequency behavior of admittance of two sections transmission-line (TSTL) terminated into a real impedance is reported. Furthermore, it is shown that the Monzon two-section dual-frequency impedance transformer is a special case of the reported technique and can be derived from this property itself. In addition, the discovered property leads to a modified dual-frequency L-type matching network that provides better transformation-ratio than the Monzon transformer. As an application, a dual-frequency T-junction power divider has been fabricated on FR4 substrate to show the practical utility of the presented theory. The simulated and measured results clearly exhibit good performance.
Metallic state in disordered quasi-one-dimensional conductors (2001)

The metallic state in conjugated polymers and single-walled carbon nanotubes is studied by dielectric spectroscopy (8--600 GHz). We have found an intriguing correlation between scattering time $(\ensuremath{\tau})$ and plasma frequency $({\ensuremath{\omega}}_{p}):\ensuremath{\tau}\ensuremath{\propto}{\ensuremath{\omega}}_{p}^{\ensuremath{-}1.3}.$ This relation conflicts with the usually applied models that only consider disorder. Based on the observed parallels with doped semiconductors, we argue that the interchain coupling ${t}_{\ensuremath{\perp}}$ plays a role comparable to the doping level and that the unusual free-carrier dynamics in the metallic state can be explained when including the role of ${t}_{\ensuremath{\perp}}$ in the conventional models.
Query Generation for Personalized Tracking of Information. (2005)

Abstract — We describe in this paper a method for generating queries from both user’s profile description and users’s community of interest description. These queries are used for a monitoring task, so that those documents which are not already known by the user are retrieved. This method was implemented and integrated to the prototype of GALILEI 1, an open source Internet/Intranet project developed for GNU/Linux. GALILEI learns a user’s profile [1], corresponding to an area of interest, by analyzing documents assessed by the user. Then, communities of interests are derived from those profiles using a specific genetic algorithm. Both profiles and groups are described by a set of terms. We use these terms to construct queries which are submitted to search engines to retrieve yet unkown documents. We conducted some experiments in order to evaluate our approach. Preliminary results from these experiments show that the suggested method can achieve an appreciable retrieval effectiveness.
Access network discovery and selection in the evolved 3GPP multi‐access system architecture (2010)

Abstract The system architecture evolution (SAE) of mobile networks specified in 3GPP release 8 comprises an evolved packet core (EPC) network to which different types of access networks can be connected. Inter‐system mobility management enables users to change the access network while maintaining ongoing data sessions. One important functionality in a 3GPP system is how a mobile terminal discovers and selects available access networks. In this paper we describe the access network discovery and selection functionality used in 3GPP release 8; we explain the differences of the methods applied for 3GPP access networks (GERAN, UTRAN, E‐UTRAN), for fixed or wireless non‐3GPP access networks (e.g. WLAN, WiMAX), as well as the optimisation used for CDMA2000 access networks. Copyright © 2010 John Wiley &amp; Sons, Ltd.
Spatially Resolved Organic Analysis of the Allende Meteorite (1989)

The distribution of polycyclic aromatic hydrocarbons(PAHs) in the Allende meteorite has been probed with two-step laser desorption/laser multiphoton ionization mass spectrometry. This method allows direct in situ analysis with a spatial resolution of 1 square millimeter or better of selected organic molecules. Spectra from freshly fractured interior surfaces of the meteorite show that PAH concentrations are locally high compared to the average concentrations found by wet chemical analysis of pulverized samples. The data suggest that the PAHs are primarily associated with the fine-grained matrix, where the organic polymer occurs. In addition, highly substituted PAH skeletons were observed. Interiors of individual chondrules were devoid of PAHs at our detection limit(about 0.05 parts per million).
Impact of Fabrication and Bioassay Surface Roughness on the Performance of Label-Free Resonant Biosensors Based On One-Dimensional Photonic Crystal Microcavities (2020)

Micro- and nanofabrication offer remarkable opportunities for the preparation of label-free biosensors exploiting optical resonances to improve sensitivity and reduce detection limit once specificity is imparted through surface biofunctionalization. Nonetheless, both surface roughness, peculiar of fabrication processes, and bioassay roughness, resulting from uneven molecular coverage of the sensing surfaces, produce light scattering and, in turn, deterioration of biosensing capabilities, especially in resonant cavities where light travels forth and back thousands to million times. Here, we present a quantitative theoretical analysis about the impact of fabrication and bioassay surface roughness on the performance of optical biosensors exploiting silicon-based, vertical one-dimensional (1D) photonic crystal resonant cavities, also taking noise sources into account. One-dimensional photonic crystal resonant cavities with different architectures and quality factors ranging from 10<sup>2</sup> to 10<sup>6</sup> are considered. The analysis points out that whereas sensitivity and linearity of the biosensors are not affected by the roughness level, either due to fabrication or bioassay, the limit of detection can be significantly degraded by both of them, depending on the quality factor of the cavity and noise level of the measurement system. The paper provides important insights into performance versus design, fabrication, and readout of biosensors based on resonant 1D photonic crystal cavities for real-setting operation.
The role of obesity in the incidence of lymphatic spread, disease-free, and overall survival: Data from the ARISER clinical trial. (2014)

435 Background: The role of obesity and the incidence of high-risk clear cell renal cell carcinoma (ccRCC) are poorly understood. We examined the association of obesity with lymphatic spread and survival using data from an international Phase III clinical trial testing the efficacy of adjuvant treatment with cG250 antibody in subjects with non-metastatic (ccRCC) at high risk for recurrence. Methods: We reviewed the clinical and pathologic records of 864 patients across three continents and 14 countries that were enrolled in a prospective, double blind, placebo controlled study of adjuvant cG250 Ab treatment for high-risk ccRCC. Clinical features analyzed included age, gender, race, body mass index (BMI), and performance status. A single pathologist centrally reviewed the specimens for TNM stage and nuclear grade. BMI was stratified into normal (&lt;25 kg/m 2 ), overweight (25.0–29.9 kg/m 2 ), obese (30.0–34.9 kg/m 2 ), and morbidly obese (≥35 kg/m 2 ). We examined the association between BMI, disease severity, and survival using logistic and Cox regression analyses, respectively. Results: Mean BMI was 28.2 kg/m 2 . The vast majority of our cohort was overweight (43%) and an additional 29% were obese (or morbidly obese). The incidence of lymphatic spread decreased with rising BMI: normal was 11%; overweight was 8%; obese was 5%; and morbidly obese was 2%. Obesity was associated with improved disease-free and overall survival, log rank=0.01 and &lt;0.01, respectively. When compared with those who were normal in weight, subjects who were obese (HR 0.50, p&lt;0.01) and morbidly obese (HR 0.22, p&lt;0.01) had significantly improved overall survival. A trend towards improved disease-free survival was found among subjects who were obese (HR 0.77, p=0.10) and morbidly obese (HR 0.69, p=0.09). Conclusions: While we cannot speak to the association between obesity and ccRCC, our study demonstrates that in a cohort of nephrectomized patients with high-risk disease, obesity is associated with a lower risk of lymphatic spread and improved overall survival.
Anatomy of the Percutaneous Presacral Space for a Novel Fusion Technique (2006)

In this study, we defined the "coronal safe zone" within the presacral space. This "safe zone" may guide surgeons when utilizing the percutaneous paracoccygeal approach.
Combining word sense and usage for modeling frame semantics (2008)

Models of lexical semantics are core paradigms in most NLP applications, such as dialogue, information extraction and document understanding. Unfortunately, the coverage of currently available resources (e.g. FrameNet) is still unsatisfactory. This paper presents a largely applicable approach for extending frame semantic resources, combining word sense information derived from WordNet and corpus-based distributional information. We report a large scale evaluation over the English FrameNet, and results on extending FrameNet to the Italian language, as the basis of the development of a full FrameNet for Italian.