gebhart/patrepeval huggingface dataset:
A Context-Aware Framework for Patient Navigation and Engagement (CANE) (2012)

Engaging patients in the management of their health care can improve the quality of their care and enhance their experience while making more efficient use of care provider resources, especially for chronic diseases. However, health care system complexity and the challenge of consumer health literac
Optimizing analog-to-digital converters for sampling extracellular potentials (2012)

In neural implants, an analog-to-digital converter (ADC) provides the delicate interface between the analog signals generated by neurological processes and the digital signal processor that is tasked to interpret these signals for instance for epileptic seizure detection or limb control. In this paper, we propose a low-power ADC architecture for neural implants that process extracellular potentials. The proposed architecture uses the spike detector that is readily available on most of these implants in a closed-loop with an ADC. The spike detector determines whether the current input signal is part of a spike or it is part of noise to adaptively determine the instantaneous sampling rate of the ADC. The proposed architecture can reduce the power consumption of a traditional ADC by 62% when sampling extracellular potentials without any significant impact on spike detection accuracy.
“On demand” redox buffering by H2S contributes to antibiotic resistance revealed by a bacteria-specific H2S donor (2017)

Understanding the mechanisms of antimicrobial resistance (AMR) will help launch a counter-offensive against human pathogens that threaten our ability to effectively treat common infections. Herein, we report bis(4-nitrobenzyl)sulfanes, which are activated by a bacterial enzyme to produce hydrogen sulfide (H<sub>2</sub>S) gas. We found that H<sub>2</sub>S helps maintain redox homeostasis and protects bacteria against antibiotic-triggered oxidative stress "on demand", through activation of alternate respiratory oxidases and cellular antioxidants. We discovered, a hitherto unknown role for this gas, that chemical inhibition of H<sub>2</sub>S biosynthesis reversed antibiotic resistance in multidrug-resistant (MDR) uropathogenic <i>Escherichia coli</i> strains of clinical origin, whereas exposure to the H<sub>2</sub>S donor restored drug tolerance. Together, our study provides a greater insight into the dynamic defence mechanisms of this gas, modes of antibiotic action as well as resistance while progressing towards new pharmacological targets to address AMR.
I-V characteristics of superconducting Ag/Bi/sub 2/Sr/sub 2/Ca/sub 2/Cu/sub 3/O/sub 10/ tapes (1995)

We have measured the current-voltage (I-V) characteristics of Ag-clad BiSrCaCuO tapes as a function of magnetic field (0-20 T) and temperature (4, 65, and 77 K). The magnetic field was applied parallel and perpendicular to the face of the tape. Samples were commercially prepared by the OPIT process. The I-V curves were analyzed by conventional means to extract J/sub c/ as a function of the applied magnetic field. Some of the curves were also fitted by an adaptation of the Ambegaokar-Halperin model from which were obtained J/sub c/ and the pinning potential. We found that, at 4 K, J/sub c/ from both sources were generally comparable with J/sub c/ /spl sim/10/sup 4/ A/cm/sup 2/ from 5 T to 20 T.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A Novel Three-Port DC-DC Converter for Integration of PV and Storage in Zonal DC Microgrids (2021)

Energy conversion process of distributed renewable energy resources and energy storage devices highly depends on the DC-DC converters as interfaces. Reducing the number of conversion stages can lead to less complex energy conversion process. Multi-port converters with their flexible structure and control strategy are good candidates for this purpose. A management and integration study of PV/battery in zonal DC microgrids is presented in this paper. Moreover, a novel isolated three-port converter with continuous input current called three-port DC-DC interface is presented. Also, a zonal DC microgrid architecture based on three-port DC-DC interface is presented and discussed. An efficient four-layer control strategy for power flow management in DC microgrid is presented and discussed thoroughly. Simulations are conducted under various operation modes and loads to demonstrate the capability of proposed interface and the presented methods and strategies. The proposed three-port DC-DC interface converts and manages the power flow in the DC microgrid with high efficiency values of 91.8% and 95.6% for two-stage and single-stage conversion processes, respectively.
Guest Editorial: Special Section on Emerging and Impacting Trends on Computer Arithmetic (2022)

The papers in this special section focus on emerging and impacting trends on computer arithmetic The computer arithmetic field encompasses the definition and standardization of arithmetic systems for computers. It also deals with issues pertaining to hardware and software implementations, testing, and verification. Researchers and practitioners of this field also work on challenges associated with using Computer Arithmetic to perform scientific and engineering calculations. As such, Computer Arithmetic can be regarded as a truly multidisciplinary field, which builds upon mathematics, computer science and electrical engineering. Thus, the range of topics addressed by Computer Arithmetic is generally very broad, spanning from highly theoretical to extremely practical contributions. Computer Arithmetic has been an active research field since the advent of computers, and it is progressively evolving following continuous advancements in technology.
OLEX: A process for producing high purity olefins (1987)

Olefins are an important resource to the petrochemical industry. They are normally produced as mixtures containing saturates and diolefins, in addition to the desired mono-olefins. The UOP Olex process represents a commercially proven and efficient means of recovering a high purity olefin product. It has been successfully applied to feeds with carbon numbers between 3 and 15. This paper reviews the principle and use of the Olex process for olefin streams, particularly C/sub 4/ olefins, and shows how the Olex process can be economically applied to meet petrochemical requirements.
Regioselective alkylation of phenol with cyclopentanol over montmorillonite K10: An efficient synthesis of 1-(2-cyclopentylphenoxy)-3-[(1,1-dimethylethyl)amino]propan-2-ol {(S )-penbutolol} (1999)

Regioselective alkylation of phenol with cyclopentanol is achieved over Montmorillonite K10 clay, producing 2-cyclopentylphenol, the key intermediate. The synthesis of optically active (S)-penbutolol 1, an important antihypertensive drug, is realized in 5 steps from 2-cyclopentylphenol by employing Sharpless asymmetric dihydroxylation.
Figure S4 from A Novel Theranostic Strategy for <i>MMP-14</i>–Expressing Glioblastomas Impacts Survival (2023)

&lt;p&gt;Immunofluorescent confocal images for MMP-14 expression in pcGBM39 tumors&lt;/p&gt;
Comparing Engineering and Non-engineering International Programs to Determine Value and Future Directions (2015)

The center provides oversight for leadership development and international activities within the
Posttranscriptional deregulation of signaling pathways in meningioma subtypes by differential expression of miRNAs (2015)

Our data provide novel insights into the contribution of miRNAs to the phenotypic spectrum in benign meningiomas. By deregulating translation of genes belonging to signaling pathways known to be important for meningioma genesis and progression, miRNAs provide a second in line amplification of growth promoting cellular signals. MiRNAs as biomarkers for diagnosis of aggressive meningiomas might prove useful and should be explored further in a prospective manner.
Comparison of four single-point phenytoin dosage prediction techniques using computer-simulated pharmacokinetic values. (1986)

The predictive abilities of the following four single-point phenytoin dosage adjustment methods were compared using computer-simulated data: the Bayesian feedback method of Vozeh et al. (B), a linearized version of the Bayesian method (LB), the population-clearance method of Graves et al. (G), and the Rambeck nomogram (R). A series of 512 "subjects" with normally distributed values for volume of distribution, weight, and the Michaelis-Menten variables Vmax and Km were simulated. The steady-state serum concentration (SSSC) resulting from the administration of a standard dose of phenytoin sodium (5 mg/kg/day) was calculated, and "subjects" with SSSCs less than or equal to 12 mg/L or greater than or equal to 17 mg/L were entered in the study. If the concentration was greater than 50 mg/L or the standard dosage exceeded Vmax, the dosage was reduced empirically by 25%. Normally distributed random errors were introduced into the SSSC values to simulate actual patient data. The pharmacokinetic values, dosages, and SSSCs were used for predicting the dosage required to attain an SSSC of 14.9 mg/L. In the unstratified population, the mean error and mean-squared error were lowest for methods G and B, followed by methods LB and R. Methods B and LB gave the highest percentages of satisfactory dosage predictions based on the resultant SSSC value. The performance of all methods was superior at initial SSSCs greater than 8 mg/L.(ABSTRACT TRUNCATED AT 250 WORDS)
Enhanced phrenic long‐term facilitation (pLTF) following intermittent hypoxia in a rat ALS model (SOD1G93A) is attenuated by spinal siRNAs targeting BDNF and TrkB synthesis (2011)

Acute intermittent hypoxia (AIH; 3, 5-min episodes, 11% O2) elicits a serotonin and BDNF-synthesis dependentform of respiratory plasticity known as pLTF. pLTF is enhanced at disease end-stage in SOD1G93A (106%) versus wild-type rats (42%; Nichols et al., 2010). The mechanism of this enhancement is unknown. The BDNF synthesis-dependent pathway to pLTF is induced by Gq coupled metabotropic 5-HT2 receptors. Other pathways can elicit phrenic motor facilitation, including activation of Gs protein-coupled metabotropic receptors (eg. 5-HT7 and A2A); this mechanism requires new synthesis of immature TrkB isoforms. We hypothesized that enhanced pLTF at ALS disease end-stage is the result of contributions from both pathways and would therefore require both BDNF and TrkB synthesis. AIH-induced pLTF was studied in anesthetized, paralyzed and ventilated SOD1G93A rats ~2 hours after intrathecal delivery of siRNAs targeting BDNF or TrkB mRNA. siBDNF attenuated pLTF to ~20% in wild-type (n = 6; p < 0.05) and SOD1G93A rats (n = 3; p < 0.05). In contrast, siTrkB had no effect on pLTF in wild-type rats (n = 5), but attenuated pLTF (~60%) in SOD1G93A rats (n = 3; p < 0.05). Thus, both Gs and Gq pathways contribute to enhanced pLTF in SOD1G93A rats. This project increases our understanding of respiratory plasticity and metaplasticity, and has important implications for the control of breathing in neurodegenerative diseases. [Supported by NIH NS057778 and T32 HL007654]
Steady-state and Dynamic Contrast MR Imaging of Human Prostate Cancer Xenograft Tumors: A Comparative Study (2002)

Understanding tumor vascular physiology is critically important for developing non-invasive, molecularly targeted diagnostic agents and therapies. In this study, using three different human prostate cancer xenografts (MDA PCa 2b, PC3, and LnCap), structural and physiological parameters of neoplastic vasculature and interstitum were explored with a widely available magnetic resonance imaging (MRI) pulse sequence (3D SPGR: spoiled gradient echo). Using dual injection technique employing two T1 contrast agents of different molecular masses (Weissleder, R., Cheng, H. C., Marecos, E., Kwong, K. K., Bogdanov, A., Jr. Eur. J. Cancer 34, 1448-1454 (1998).), steady state (SS) MRI measurements and dynamic contrast agent enhancement (DCE) MRI measurements were simultaneously acquired and analyzed using a two-compartment model for calculating parameters reflecting tumoral architecture and physiology. In particular, interstitial volume and vascular permeability were independently quantified using these two different MRI techniques. Relative vascular water exchange rate, calculated by the flip angle (FA) dependence of measured blood volume using SS technique, and vascular permeability of contrast agent, extrapolated from DCE MRI, were compared. It was found that the SS and DCE techniques were comparable and yielded similar qualitative results for extravascular compartment (interstitial volume). However, the permeability (water exchange rate and contrast agent vascular permeability) values were in disagreement. The results of MR studies are important for interpreting optical imaging results obtained using long-circulating of tumor-associated enzymatic activity.
Coupling of AlkynylTMS Derivatives with Vinylic Iodides. An Efficient Route to 1,3-Enynes and Dienes (2001)

[reaction: see text] CuCl-promoted coupling of alkynylTMS derivatives with vinyl iodides leads to 1,3-enynes in high yield. Enynes prepared from homopropargylic alcohols undergo intramolecular hydrosilylation and subsequent silyl cleavage with TBAF to afford 1,3-dienes.
大功率In(Ga)As/GaAs量子点激光器 (2000)

利用分子束外延技术和S-K生长模式，系统研究了InAs/GaAs材料体系应变自组装量子点的形成和演化。研制出激射波长λ≈960nm,条宽100μnm,腔长800μm的In(Ga)As/GaAs量子点激光器
The role of one’s own voice in auditory virtual environments (2000)

The sound of our own voices contributes significantly to the way we perceive real and virtual environments and has strong implications on the way we speak. It allows speech to be controlled, which is of particular relevance in acoustically ‘‘difficult’’ situations, for example when speaking in a noisy environment. Starting from a model of the different pathways relevant to the perception of one’s own voice, the implementation of the model in an auditory virtual environment generator is described. The results of an auditory validation experiment show that the naturalness of one’s own voice is significantly increased when the model is applied. Furthermore, this system can serve as a tool for psychoacoustic research regarding the perception of one’s own voice. In a second experiment the implications of a plausible presentation of one’s own voice on the sense of presence in an auditory virtual environment were studied. For this purpose, the virtual environment generator was enhanced to a multiuser system so that it could be used as an auditory teleconferencing system where two or more participants were perceptually placed in one virtual room. Finally, possible commercial applications for the implemented model are identified and briefly described.
Using an Integrated -Omics Approach to Identify Key Cellular Processes That Are Disturbed in the Kidney After Brain Death (2015)

In an era where we are becoming more reliant on vulnerable kidneys for transplantation from older donors, there is an urgent need to understand how brain death leads to kidney dysfunction and, hence, how this can be prevented. Using a rodent model of hemorrhagic stroke and next-generation proteomic and metabolomic technologies, we aimed to delineate which key cellular processes are perturbed in the kidney after brain death. Pathway analysis of the proteomic signature of kidneys from brain-dead donors revealed large-scale changes in mitochondrial proteins that were associated with altered mitochondrial activity and morphological evidence of mitochondrial injury. We identified an increase in a number of glycolytic proteins and lactate production, suggesting a shift toward anaerobic metabolism. Higher amounts of succinate were found in the brain death group, in conjunction with increased markers of oxidative stress. We characterized the responsiveness of hypoxia inducible factors and found this correlated with post-brain death mean arterial pressures. Brain death leads to metabolic disturbances in the kidney and alterations in mitochondrial function and reactive oxygen species generation. This metabolic disturbance and alteration in mitochondrial function may lead to further cellular injury. Conditioning the brain-dead organ donor by altering metabolism could be a novel approach to ameliorate this brain death-induced kidney injury.
Heterogeneous Borrowers, Liquidity, and the Search for Credit (2002)

How to explain variations in financial development across time and across countries that deviate from real activity? We develop a general equilibrium model of credit formation where borrowers and lenders must search for matches and where the composition of borrowers adjusts to satisfy equilibrium entry conditions. We show that if market liquidity dries up as a result of fundamental shocks to the system, fewer borrowers will participate in the credit market with low-quality borrowers suffering disproportionately because of a flight to quality. However, less liquid credit markets may or may not be associated with lower social output. The result depends on whether the effect of reduced market participation outweighs that of higher average quality, where the balance of the two effects depends crucially on the source of the liquidity shock.
Uric Acid Levels and All-Cause and Cardiovascular Mortality in the Hemodialysis Population (2011)

Higher uric acid levels were associated with lower risk of all-cause and CV mortality in the hemodialysis population. These results are in contrast to the association of hyperuricemia with higher cardiovascular risk in the general population and should be the subject of further research.
Assessing the regulation of T cell function by distinct cytokine combinations using GuavaFlo, a cytometry-based system for multidimensional cellular analysis. (B206) (2007)

Abstract Precise regulation of effector function is critical for mounting a potent, yet specific, immune response to a given antigenic challenge. Distinct cytokine combinations present within a given microenvironment can induce changes in the phenotype and effector functions of immune cells that differ dramatically from the effects exerted by each cytokine alone. Using a multiparametric analysis approach, we investigated the phenotypic and functional changes of all combinations of 6 cytokines (IL-2, IL-4, IL-7, IL-12, TNF-α, and TGF-β) on human T-cell isolates derived. Cultures were assessed for changes in maturation/activation state, as well as determination of their individual proliferative capacity and viability. Cultures were subject to cytokine production profiling through intracellular staining. Samples were acquired using Guava’s EasyCyte Plus system and integrated GuavaFlo software, an analysis platform designed specifically to simplify and expedite the assessment of plate level flow cytometry data sets. We found that unique combinations of cytokines had profound and highly varied effects on lymphocyte fate and function in vitro. Demonstrations of synergy, dominance, and substitution amongst multiple cytokines in our experimental system may reflect actual paradigms underlying such processes as the differentiation of T cell subsets into effector and resting memory phenotypes in vivo.
Small Signal Model of Modular Multilevel Converter with Power Synchronization Control (2023)

Power synchronization control (PSC) is one of the popular control schemes in grid-forming control-based converters because it simulates the grid support capability of conventional synchronous generators. However, prior research is based on two-level converters which do not have complex internal circuits, and whether PSC can be directly applied to the modular multilevel converter (MMC) topology since MMC has sub-module capacitor voltage ripples and inherent second harmonic circulating current algorithm, has not been analyzed. This paper establishes the small signal model of MMC with PSC considering the MMC internal dynamic and circulating current suppression control (CCSC). The power oscillation phenomenon when grid short-circuit ratio (SCR) increases is also demonstrated with the closed-loop system eigenvalues calculation and verified with the experimental results.
Multitone characterization and design of FET resistive mixers based on combined active source-pull/load-pull techniques (1998)

A dual six-port-based measurement setup was developed to synthesize five source and load impedances simultaneously. The setup can perform nonlinear measurements with multifrequency excitation. Active source-pull/load-pull measurements obtained for an NE-9001 transistor operated in a C-band field-effect transistor (FET) resistive mixer mode allow one to optimize the linearity of the mixer while maintaining a typical conversion loss of approximately 7 dB. Two-tone verification at 3.9000 and 3.9005 GHz showed that the level of in-band third-order intermodulation products could be reduced to -50 dBc, with a well-chosen output intermediate frequency (IF) load impedance and sufficient local oscillator (LO) power. The measured performance of the realized mixer is in good agreement with that predicted at the transistor characterization step of the design.
Real Time Reaction Dynamics in Carbon Nanotubes (2001)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTReal Time Reaction Dynamics in Carbon NanotubesToshiya Okazaki, Kazutomo Suenaga, Kaori Hirahara, Shunji Bandow, Sumio Iijima, and Hisanori ShinoharaView Author Information Department of Chemistry, Nagoya University Nagoya 464-8602, Japan Japan Science and Technology Corporation c/o Department of Physics, Meijo University Nagoya, 468-8502, Japan NEC Corporation, Tsukuba, 305-8501, Japan Cite this: J. Am. Chem. Soc. 2001, 123, 39, 9673–9674Publication Date (Web):September 11, 2001Publication History Received14 June 2001Published online11 September 2001Published inissue 1 October 2001https://pubs.acs.org/doi/10.1021/ja016415hhttps://doi.org/10.1021/ja016415hrapid-communicationACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views602Altmetric-Citations77LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Carbon nanotubes,Electron energy loss spectroscopy,Irradiation,Molecules,Transmission electron microscopy Get e-Alerts