gebhart/patrepeval huggingface dataset:
Output-inductor-less full-bridge converter with SiC-MOSFETs for low noise and ZVS operation (2016)

In this paper, a high power-density output-inductor-less full-bridge converter for the HVDC power distribution system is proposed. The new reduction techniques of switching loss and noise in the output-inductor-less full-bridge converter by using SiC-MOSFETs are applied. As the result, the power loss is reduced by 20W in a wide load range, and the noise is also reduced. Furthermore, a high power density of 15W/cm3 is achieved by the experimental breadboard with power level of 1kW.
Data from WWOX and p53 Dysregulation Synergize to Drive the Development of Osteosarcoma (2023)

&lt;div&gt;Abstract&lt;p&gt;Osteosarcoma is a highly metastatic form of bone cancer in adolescents and young adults that is resistant to existing treatments. Development of an effective therapy has been hindered by very limited understanding of the mechanisms of osteosarcomagenesis. Here, we used genetically engineered mice to investigate the effects of deleting the tumor suppressor &lt;i&gt;Wwox&lt;/i&gt; selectively in either osteoblast progenitors or mature osteoblasts. Mice with conditional deletion of &lt;i&gt;Wwox&lt;/i&gt; in preosteoblasts (&lt;i&gt;Wwox&lt;sup&gt;Δosx1&lt;/sup&gt;&lt;/i&gt;) displayed a severe inhibition of osteogenesis accompanied by p53 upregulation, effects that were not observed in mice lacking &lt;i&gt;Wwox&lt;/i&gt; in mature osteoblasts. Deletion of &lt;i&gt;p53&lt;/i&gt; in &lt;i&gt;Wwox&lt;sup&gt;Δosx1&lt;/sup&gt;&lt;/i&gt; mice rescued the osteogenic defect. In addition, the &lt;i&gt;Wwox;p53&lt;sup&gt;Δosx1&lt;/sup&gt;&lt;/i&gt; double knockout mice developed poorly differentiated osteosarcomas that resemble human osteosarcoma in histology, location, metastatic behavior, and gene expression. Strikingly, the development of osteosarcomas in these mice was greatly accelerated compared with mice lacking p53 only. In contrast, combined WWOX and p53 inactivation in mature osteoblasts did not accelerate osteosarcomagenesis compared with p53 inactivation alone. These findings provide evidence that a WWOX–p53 network regulates normal bone formation and that disruption of this network in osteoprogenitors results in accelerated osteosarcoma. The &lt;i&gt;Wwox;p53&lt;sup&gt;Δosx1&lt;/sup&gt;&lt;/i&gt; double knockout establishes a new osteosarcoma model with significant advancement over existing models. &lt;i&gt;Cancer Res; 76(20); 6107–17. ©2016 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Fabrication-Tolerant Four-Mode Waveguide Crossing Based on PhC-like Subwavelength Structures at 2 µm (2021)

A four-mode waveguide crossing based on photonic-crystal-like subwavelength structures is proposed at the 2 µm waveband, together with a novel direct binary search algorithm for obtaining fabrication-tolerant structures.
In vitro and in vivo Candicidal Activities of 2-(<i>p</i>-n-Hexylphenylamino)-1,3-Thiazoline (1991)

The 2-amino-1,3-thiazoline, 2-(p-n-hexylphenylamino)-1,3-thiazoline (MDL 20,245) killed 10(5) logarithmic or stationary phase Candida albicans/ml in less than 1 h. Miconazole killed logarithmic phase cells at that rate, but miconazole, clotrimazole or econazole killed stationary phase cells at a slower rate of 10(2)-10(4) cells/ml in 24 h. MDL 20,245 induced efflux of K+ and L[U-14C] lysine from C. albicans, indicating that the candicidal mechanism is to exert direct damage upon the cytoplasmic membrane. The activity of MDL 20,245 in vitro was antagonized by fatty acids, triglycerides and phospholipids. Topical application of MDL 20,245 ointment (10% w/v) twice per day for 4 days to rats suppressed C. albicans-induced vaginitis 100%. Single-dose regimens of MDL 20,245, miconazole or clotrimazole correlated with 97, 90 and 73% suppression, respectively. These data suggest that MDL 20,245 may be effective in the treatment of C. albicans-induced vaginitis in humans.
Electric Company Portfolio Optimization Under Interval Stochastic Dominance Constraints. (2005)

This paper addresses the problem of market risk management for a company in the electricity industry. When dealing with corporate volumetric exposure, there is a need for a methodology that helps to manage the aggregate risks in energy markets. The originality of the approach presented lies in the use of intervals to formulate a specic portfolio optimization problem under stochastic dominance constraints.
Separation of Tricomponent Protein Mixtures with Triblock Nanorods (2006)

Two-component triblock magnetic nanorods with gold end blocks and nickel interior blocks have been synthesized and used as affinity templates for the simultaneous and efficient separation of a three-component protein mixture. The gold blocks were selectively functionalized with 11-amino-1-undecanethiol, and then glutaraldehyde was used to covalently attach nitrostreptavidin to them. His-tagged proteins bind to the nickel block and biotin-tagged proteins bind to the functionalized gold ends, allowing one to separate a mixture of three proteins with a single material. Each surface-bound protein can be released selectively using imidazole for the His-tagged protein and biotin for the biotinylated protein.
7T versus 3T phosphorous magnetic resonance spectroscopy in patients with dilated cardiomyopathy (2015)

Background Phosphorous magnetic resonance spectroscopy (PMRS) allows insight into cardiac energetics in vivo, but it is a technique with an intrinsically low signal to noise ratio (SNR). The 2.4x increased SNR, that is predicted by theory at 7T compared to 3T, should allow detection of smaller changes in metabolite concentrations or measurement of changes in smaller patient groups, which will further our understanding of cardiac energetics. This study represents the first cardiac P-MRS patient data acquired at a 7 Tesla field strength.
Modified Field Oriented Control for Fail-Operational Multi-Phase Induction Motor Drives (2020)

Recently, multiphase machines have gained worldwide attention from the research community and industry for their applications in the electric ship propulsion, electric transports, more-electric aircrafts and for those particular loads that require continuous operation of the machine after one or more phases become open-circuited. A fault can be due to the loss of one of the leg transistors in the voltage source inverter, or be internal to the machine, affecting one of the phase windings. Multiphase machines can continue to operate even in the case where more than one phase is open-circuited, while for a three-phase machine, post-fault operation is possible only if one phase is opened and the star point of the machine is connected to the dc mid-point of the inverter.In this papers the modeling and control of a five-phase induction machine with the field oriented control technique are presented; then, an algorithm for the post fault operation when one stator phase is open-circuited has been proposed and the results of the simulations, carried out with different load torques and reference speeds, have been reported and discussed.
On the Detection of the Signature of Silicon Nanoparticle Dust Grains in Coronal Holes (2003)

We report on polarization measurements in the Fe XIII line at 1074.7 nm made during the total solar eclipse of 2001 June 21, which yielded the first signature of interplanetary dust in the inner corona. In the first-ever images at this wavelength, the signature of dust appears as a tangentially polarized emission in the radial extension of the low-temperature and low-density coronal holes as opposed to a predominantly radial polarization direction in the rest of the corona. The observed emission and polarization are attributed to fluorescence from silicon nanoparticle dust grains in the inner corona.
Late Mortality and Morbidity in Recipients of Long-Term Renal Allografts (1983)

No AccessJournal of Urology1 Jul 1983Late Mortality and Morbidity in Recipients of Long-Term Renal Allografts R.L. Kirkman, T.B. Strom, M.R. Weir, and N.L. Tilney R.L. KirkmanR.L. Kirkman More articles by this author , T.B. StromT.B. Strom More articles by this author , M.R. WeirM.R. Weir More articles by this author , and N.L. TilneyN.L. Tilney More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)51046-0AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Late Mortality and Morbidity in Recipients of Long-Term Renal Allografts." The Journal of Urology, 130(1), p. 197 © 1983 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 130Issue 1July 1983Page: 197 Advertisement Copyright & Permissions© 1983 by The American Urological Association Education and Research, Inc.MetricsAuthor Information R.L. Kirkman More articles by this author T.B. Strom More articles by this author M.R. Weir More articles by this author N.L. Tilney More articles by this author Expand All Advertisement PDF downloadLoading ...
[3H]LY303870, a Novel Nonpeptide Radioligand for the NK‐1 Receptor (1996)

We synthesized a potent and selective antagonist radioligand for the neurokinin (NK)-1 receptor and characterized its binding to guinea pig striatal membranes. (R)-N-[2-[Acetyl[3H3][(2-methoxyphenyl)-methyl]amino]- 1-(1H-indol-3-ylmethyl) ethyl][1,4'-bipiperidine]- 1'-acetamide ([3H]LY303870) binds to a single class of sites with an equilibrium KD of 0.22 nM and a Bmax of 723 fmol/mg of protein. Unlabeled LY303870 potently inhibited the binding with an IC50 of 0.56 nM, whereas the less active (S)-enantiomer (LY306155) was substantially less potent. The nonpeptide NK-1 antagonists (+/-)-CP96,345 and (+/-)-RP 67580 had IC50 values of 0.74 and 49 nM, respectively. Substance P (SP) was also a potent inhibitor with with an IC50 of 3.1 nM. The inhibition by SP could be separated into two components: a high-affinity component with a Ki of 0.53 nM and a lower-affinity component with a Ki of 155 nM. Addition of 100 microM guanylyl 5'-imidodiphosphate [Gpp(NH)p] in the incubation increased the relative amount of the low-affinity agonist state of the receptor. Consistent with the antagonist properties of LY303870, the dissociation rate of [3H]-LY303870 was not changed by the presence of 100 microM Gpp(NH)p. The distribution of [3H]LY303870 binding sites in the guinea pig brain closely matched the distribution of NK-1 receptors labeled by [3H]SP. Therefore, [3H]LY303870 is a potent and selective antagonist radioligand for NK-1 receptors in guinea pig brain. In addition, regulation of NK-1 agonist affinity by guanine nucleotides is similar to that seen for monoaminergic receptors.
High Blood Neutrophil-to-Lymphocyte Ratio Is an Indicator of Poor Prognosis in Malignant Mesothelioma Patients Undergoing Systemic Therapy (2010)

Our results indicate that NLR is an independent predictor of survival for patients with MM undergoing systemic therapy.
Splicing modulation sensitizes chronic lymphocytic leukemia cells to venetoclax by remodeling mitochondrial apoptotic dependencies (2018)

The identification of targetable vulnerabilities in the context of therapeutic resistance is a key challenge in cancer treatment. We detected pervasive aberrant splicing as a characteristic feature of chronic lymphocytic leukemia (CLL), irrespective of splicing factor mutation status, which was associated with sensitivity to the spliceosome modulator, E7107. Splicing modulation affected CLL survival pathways, including members of the B cell lymphoma-2 (BCL2) family of proteins, remodeling antiapoptotic dependencies of human and murine CLL cells. E7107 treatment decreased myeloid cell leukemia-1 (MCL1) dependence and increased BCL2 dependence, sensitizing primary human CLL cells and venetoclax-resistant CLL-like cells from an Eμ-TCL1-based adoptive transfer murine model to treatment with the BCL2 inhibitor venetoclax. Our data provide preclinical rationale to support the combination of venetoclax with splicing modulators to reprogram apoptotic dependencies in CLL for treating venetoclax-resistant CLL cases.
Damage Initiation in Bonded Particulate Networks: 3D Simulations (2001)

Abstract Several promising Li-ion technologies incorporate micro- and nanoarchitectured carbon networks, typically in the form of whisker/particle blends bonded with thermoplastic binders, in the electrodes. Degradation of these battery electrode materials is currently a persistent problem, with damage presenting as blistering and/or delamination. We are investigating bonding in micro- and nanostructured materials in order to predict onset of this degradation of these stochastic materials. Here, we describe a general methodology in modeling the small junctures in these porous network materials. We have found previously that the joint properties are the controlling feature in a significant class of materials, and suggest that 3D simulations on the bonds may be used in 2D simulations of overall network behavior.
Paper # 11: Biomechanical Comparison of Anatomic Double‐Bundle, Anatomic Single‐Bundle and Non‐Anatomic Single‐Bundle Anterior Cruciate Ligament Reconstructions (2011)

The anterior translation during the pivot-shift and internal rotational laxity after the anatomic double-bundle and the laterally placed single-bundle ACL reconstructions were significantly better than after the single-bundle reconstruction placed in the femoral anteromedial bundle attachment with hamstrings tendon grafts.
A simple refinement of slow-start of TCP congestion control (2002)

This paper presents a new variant of slow-start, called smooth-start, which provides a smooth transition between the exponential and linear growth phases of the TCP congestion window. Slow-start is known to make an abrupt transition between the slow-start and congestion-avoidance phases, and hence, often causes multiple packet losses from a window of data and retransmission timeouts, which, in turn reduce the effective throughput and result in global synchronization. Smooth-start solves this problem by approaching the slow-start threshold more gradually. Our extensive simulation results show that smooth-start can significantly reduce both packet losses and traffic burstiness, thus improving the performance of TCP congestion control at the start of a TCP connection or after a retransmission timeout. Furthermore, smooth-start is very simple to implement and requires TCP modifications at the sender side only.
Cytogenetic and Molecular Tumor Profiling for Type 1 and Type 2 Papillary Renal Cell Carcinoma (2009)

Type 2 PRCC is associated with more aggressive clinicopathologic features and worse outcome. Molecular and chromosomal alterations can distinguish between PRCC subtypes and influence their prognosis. The effect of 3p loss on survival in PRCC is opposite to the relationship seen in clear cell RCC.
Real -Time Kinematic (RTK) Processing for Dual-Frequency GPS/GLONASS (1998)

In this article we present a new algorithm for real-time
kinematic applications, implementation technique and test
results (patent pending).
The algorithm includes the following steps: extrapolation
of the reference station observables; a recurrent procedure
of averaging float ambiguities (using both code and carrier
phase data); cycle slip detection and correction; ambiguity
resolution; and finally, calculation of the baseline.
Experimental results including statistical data on the
baseline accuracy are presented. The effect the number of satellites, dual frequency data, and multipath have on RTK
performance is studied as well.
Some particular problems related to using combined
GPS/GLN data are also examined in this article.
Widely Wavelength-Swept Single-Longitudinal-Mode Fiber Laser With Ultra-Narrow Linewidth in C+L-Band (2022)

This study proposes and demonstrates a widely wavelength-swept single-longitudinal-mode (SLM) erbium-doped fiber laser (EDFL) enabled by a dual-coupler-ring based compound-cavity (DCR-CC) filter, a fiber Fabry-Pérot tunable filter (FFP-TF) and a C+L-band erbium-doped fiber amplifier (EDFA). Moreover, it develops a novel methodology utilizing the signal-flow graph combined with the matrix algebra to analyze the DCR-CC filter and obtain its essential design parameters for SLM selection of the EDFL. The C+L-band EDFA is constructed to provide a gain range >90 nm. On the other hand, it demonstrates that, under a sweep-rate ≤100 Hz, a lasing wavelength-swept range >87 nm is obtained, the SLM operation is permanently guaranteed for every instantaneous lasing wavelength. Furthermore, the instantaneous lasing parameters of an optical signal-to-noise ratio ≥66 dB, a relative intensity noise ≤−153.33 dB/Hz@≥3 MHz, a linewidth ≤625 Hz and a power fluctuation ≤0.704 dB are achieved. The distinguished performance of the proposed fiber laser enables it to have a significant potential for application in optical frequency domain reflectometry, spectroscopy and Lidar system.
Rapid-Injection NMR Study of Iodo- and Cyano-Gilman Reagents with 2-Cyclohexenone:  Observation of π-Complexes and Their Rates of Formation (2002)

Rapid-injection is a very useful technique for the preparation of temperature-sensitive and air-sensitive compounds in the cold, nitrogen-filled probe of an NMR spectrometer. We have used this method to prepare solutions of pi-complexes from 2-cyclohexenone and prototypical cuprates Me2CuLi.LiI and Me2CuLi.LiCN, and we have assigned structures on the basis of 1H and 13C NMR. In each case two pi-complexes were observed, and in the former, their rates of formation were measured by rapid-injection 1H NMR and EXSY spectroscopy. These results provide insights into the normal and anomalous conjugate addition reactions of organocuprates.
Nickel-Manganese Catalysts as Biomimics of the active site of NiFe hydrogenases: a Combined Electrocatalytical and DFT Mechanistic Study (2011)

International audience
Formation and Role of p-n Contacts in CuO-SnO2 Based H2S Sensor. (1996)

The sensitivity of a semiconductor sensor using SnO2 to H2S in air could be enormously promoted by loading SnO2 with a small amount of CuO. However, response kinetics began to deteriorate rather sharply as the H2S concentration decreased below a certain limit, which depended on CuO loadings. XPS measurements on a series of CuO-SnO2 samples calcined in air revealed that the binding energies (BEs) for O1s and Sn3d5/2 levels shifted downward from those of pure SnO2, while Cu2p3/2 level showed an upward shift from that of pure CuO. With increasing CuO loading, the shifts in BE increased or decreased linearly for O1s and Sn3d5/2 levels or Cu2p3/2 level, respectively, indicating continuous shifts in Fermi levels of SnO2 and CuO. For a fixed CuO loading, the magnitudes of the BE shifts were dependent on the methods of CuO loading, reflecting differences in the dispersion of CuO particles on SnO2 grains. These phenomena were well consistent with the formation of p-n contacts between the finely dispersed CuO (p) and the underlying SnO2 (n) grains. The sensitivity to H2S was shown to be well correlated with the magnitudes of the BE shifts, indicating that the formation of the p-n contacts in air and the rupture of them upon exposure to H2S are the origin of the high H2S sensitivity.
BASIC-LIVER, PANCREAS, AND BILIARY TRACT Inhibition of T-Cell Inflammatory Cytokines, Hepatocyte NF-B Signaling, and HCV Infection by Standardized Silymarin (2007)

Background & Aims: Chronic hepatitis C is a serious global medical problem necessitating effective treatment. Because standard of care with pegylated interferon plus ribavirin therapy is costly, has significant side effects, and fails to cure about half of all infections, many patients seek complementary and alternative medicine to improve their health, such as Silymarin, derived from milk thistle (Silybum marianum). Milk thistle’s clinical benefits for chronic hepatitis C are unsettled due to variability in standardization of the herbal product. Methods: In the current study, we focused on the anti-inflammatory and antiviral properties of a standardized Silymarin extract (MK-001). Results: MK-001 inhibited expression of tumor necrosis factor-alpha in anti-CD3 stimulated human peripheral blood mononuclear cells and nuclear factor kappa B-dependent transcription in human hepatoma Huh7 cells. Moreover, MK-001 dose dependently inhibited infection of Huh7 and Huh7.5.1 cells by JFH-1 virus. MK-001 displayed both prophylactic and therapeutic effects against HCV infection, and when combined with interferon-, inhibited HCV replication more than interferon- alone. Commercial preparations of Silymarin also displayed antiviral activity, although the effects were not as potent as MK-001. Antiviral effects of the extract were attributable in part to induction of Stat1 phosphorylation, while interferon-independent mechanisms were suggested when the extract was biochemically fractionated by high-performance liquid chromatography. Silybin A, silybin B, and isosilybin A, isosilybin B elicited the strongest anti-NF-B and anti-HCV actions. These effects were independent of MK-001induced cytotoxicity. Conclusions: The data indicate that Silymarin exerts anti-inflammatory and antiviral effects, and suggest that complementary and alternative medicine-based approaches may assist in the management of patients with chronic hepatitis C.
Observation of the decay Λb0→Λc+pp‾π− (2018)

The decay 0 b + c p p -is observed using pp collision data collected with the LHCb detector at centreof-mass energies of s = 7 and 8 Tev, corresponding to an integrated luminosity of 3 fb -1 . The ratio of branching fractions between
A 0.65V 2.5GHz Fractional-N Frequency Synthesizer in 90nm CMOS (2007)

A 2.5GHz fractional-N synthesizer is realized in a digital 90nm CMOS technology. The RF dividers operate at 0.65V while the remainder of the PLL operates at 0.5V; no special devices or voltage boosting is used to achieve the 0.5V operation. The synthesizable range covers 2.4 to 2.6GHz with a phase noise of -55dBc/Hz in band and -120dBc/Hz at a 3MHz offset. The synthesizer dissipates 7mW and occupies 0.14mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .
Endothelial-specific expression of CIDEC improves high-fat diet-induced vascular and metabolic dysfunction (2022)

&lt;p&gt; &lt;/p&gt; &lt;p&gt;Cell death-inducing DNA fragmentation factor-α-like effector C (CIDEC), originally identified to be a lipid-droplet associated protein in adipocytes, positively associates with insulin sensitivity. Recently, we discovered that it is expressed abundantly in human endothelial cells (ECs) and regulates vascular function. The present study was designed to characterize the physiological effects and molecular actions of endothelial CIDEC in the control of vascular phenotype and whole-body glucose homeostasis. To achieve this, we generated a humanized mouse model expressing endothelial-specific human CIDEC (E-CIDECtg). E-CIDECtg mice exhibited protection against HFD-impaired glucose intolerance, insulin resistance, and dyslipidemia. Moreover, these mice displayed improved insulin signaling and eNOS activation, enhanced endothelium-dependent vascular relaxation, and improved vascularization of adipose tissue, skeletal muscle, and heart. Mechanistically, we identified a novel interplay of CIDEC-VEGFA-VEGFR2 that reduced VEGFA and VEGFR2 degradation thereby increasing VEGFR2 activation. Overall, our results demonstrate a protective role of endothelial CIDEC against obesity-induced metabolic and vascular dysfunction, in part, by modulation of VEGF signaling. These data suggest that CIDEC may be investigated as a potential future therapeutic target for mitigating obesity-related cardiometabolic disease.&lt;/p&gt;