gebhart/patrepeval huggingface dataset:
ICU glucose monitoring measured in plasma using mid-infrared spectroscopy (2010)

There are increasing calls for a highly accurate, automated system to enable tight glycemic control and avoid hypoglycemia in an ICU setting. OptiScan Biomedical has developed a glucose monitor based on mid-infrared spectroscopy that draws blood samples (120 μl) and measures plasma glucose concentrations approximately every 15 minutes. The goal of this study was to validate the performance of the OptiScan model 5000 (OptiScanner) at different glycemic levels in a healthy diabetic patient population.
Suche nach chiralen Katalysatoren durch Ligandenvielfalt: substratspezifische Katalysatoren und Screening von Liganden an fester Phase (1997)

Eine sehr wirksame Strategie für die Suche nach chiralen Katalysatoren ist die Ligandenoptimierung auf festen Trägern, wobei einzigartige Möglichkeiten für die Identifizierung substratspezifischer Katalysatoren eröffnet werden. Die Strategie führte zur Entdeckung von Liganden, die ungewöhnliche Eigenschaften aufweisen und mit anderen Methoden möglicherweise unentdeckt geblieben wären. So wurden mit den sehr ähnlichen Liganden 1 und 2 in der Addition von TMSCN an Cyclopentenoxid völlig unterschiedliche Enantioselektivitäten erzielt (siehe rechts). TMS = Trimethylsilyl. magnified image
Multi-GPU Implementation of LU Factorization (2012)

LU factorization is the most computationally intensive step in solving systems of linear equations. By obtaining first the LU factorization of the coefficient matrix, we then may readily solve the system using backward substitution. The computational cost of LU factorization in terms fioating point operations is cubic. There are various efforts to improve the performance of LU factorization. We propose a multi-core multi-GPU hybrid LU factorization algorithm that leverages the strengths of both multiple CPUs and multiple GPUs. Our algorithm uses some of the CPU cores for panel factorization, and the rest of the CPU cores together with all the available GPUs for trailing submatrix updates. Our algorithm employs both dynamic scheduling and static scheduling. Experiments show that our approach reaches 1134 Gflop/s with 4 Fermi GPU boards when combined with the total of 48 CPU cores from AMD. This is the first time such level of performance have been reported in a shared memory environment. Execution trace shows that our code also achieves good load balance and high system utilization.
An investigation of multispectral imaging for the mapping of pigments in paintings (2008)

Compared with colorimetric imaging, multispectral imaging has the advantage of retrieving spectral reflectance factor of each pixel of a painting. Using this spectral information, pigment mapping is concerned with decomposing the spectrum into its constituent pigments and their relative contributions. The output of pigment mapping is a series of spatial concentration maps of the pigments comprising the painting. This approach was used to study Vincent van Gogh's The Starry Night. The artist's palette was approximated using ten oil pigments, selected from a large database of pigments used in oil paintings and a priori analytical research on one of his self portraits, executed during the same time period. The pigment mapping was based on single-constant Kubelka-Munk theory. It was found that the region of blue sky where the stars were located contained, predominantly, ultramarine blue while the swirling sky and region surrounding the moon contained, predominantly, cobalt blue. Emerald green, used in light bluish-green brushstrokes surrounding the moon, was not used to create the dark green in the cypresses. A measurement of lead white from Georges Seurat's La Grande Jatte was used as the white when mapping The Starry Night. The absorption and scattering properties of this white were replaced with a modern dispersion of lead white in linseed oil and used to simulate the painting's appearance before the natural darkening and yellowing of lead white oil paint. Pigment mapping based on spectral imaging was found to be a viable and practical approach for analyzing pigment composition, providing new insight into an artist's working method, the possibility for aiding in restorative inpainting, and lighting design.
Ileal and jejunal Peyer’s patches play distinct roles in mucosal immunity of sheep (1999)

The majority of pathogens enter the body through mucosal surfaces and it is now evident that mucosal immunity can provide effective disease protection. However, the induction of mucosal immunity will require efficient targeting of mucosal vaccines to appropriate mucosa-associated lymphoid tissue. An animal model, based upon the surgical preparation of sterile intestinal 'loops' (blind-ended segments of intestine), was developed to evaluate mucosal and systemic immune responses to enteric vaccines in ruminants. The effectiveness of end-to-end intestinal anastomoses was evaluated and fetal surgery did not disrupt normal intestinal function in lambs up to 6-7 months after birth. The immunological competence of Peyer's patches (PP) within the intestinal 'loops' was evaluated with a human adenovirus 5 vector expressing the gD gene of bovine herpesvirus-1. This vaccine vector induced both mucosal and systemic immune responses when injected into intestinal 'loops' of 5-6-week-old lambs. Antibodies to the gD protein were detected in the lumen of intestinal 'loops' and serum and PP lymphocytes proliferated in response to gD protein. The immune competence of ileal and jejunal PP was compared and these analyses confirmed that jejunal PP are an efficient site for the induction of mucosal immune responses. This was confirmed by the presence of gD-specific antibody-secreting cells in jejunal but not ileal PP. Systemic but not mucosal immune responses were detected when the vaccine vector was delivered to the ileal PP. In conclusion, this model provided an effective means to evaluate the immunogenicity of potential oral vaccines and to assess the immunological competence of ileal and jejunal Peyer's patches.
Sensitivity of human acute myeloid leukaemia to diphtheria toxin‐GM‐CSF fusion protein (1997)

The potential to selectively eliminate acute myeloid leukaemia (AML) cells with the GM-CSF-diphtheria toxin fusion protein (DT-GM-CSF) was studied under conditions of autonomous proliferation in vitro with no growth factors (GFs) added and after growth stimulation with a mixture of human (hu)G-CSF, huIL-3 and huSCF. DNA synthesis was maximally inhibited after 48 h exposure to DT-GM-CSF. Cell viability and AML colony forming ability in vitro were reduced. 18/22 samples were found to be sensitive to DT-GM-CSF, with 50% inhibition of DNA synthesis (ID50) at concentrations ranging from 0.1 to 16 ng/ml, and four samples were minimally or not sensitive to DT-GM-CSF (ID50 > or = 99 ng/ml). From the 15 samples which showed autonomous proliferation, 13 were sensitive to inhibition of proliferation by DT-GM-CSF. The level of GM-CSF receptor (GM-CSFR) expression was determined by flow cytometry after labelling with specific antibodies for the alpha and beta subunits. Although the toxicity to DT-GM-CSF was specifically mediated by the GM-CSFR, no correlation was found between the level of expression of the GM-CSFR alpha or beta subunit and the sensitivity for DT-GM-CSF. These in vitro studies show that the DT-GM-CSF fusion protein can be used for specifically targeting and eliminating leukaemic cells in the majority of AML cases.
On-chip manipulation and magnetization assessment of magnetic bead ensembles by integrated spin-valve sensors (2002)

Manipulation and detection of magnetic beads on a semiconductor chip opens up new perspectives for analysis of magnetically labeled specimens in biomechanical micro-electromechanical systems for biological applications. Sensitive spin-valve sensors were integrated with magnetic field generating conductors to assess the behavior of ensembles of superparamagnetic nanoparticles 300 nm in diameter that contain 75%–80% magnetite. The spin-valve multilayer including a nanooxide layer achieves 8% magnetoresistance (MR) for an integrated device of 2×16 μm2. Motion of the magnetic particles towards and across the sensor is achieved by two tapered magnetic field generating current conductors. The spin-valve sensor detects the stray magnetic field that emanates from the ensemble of magnetic particles. We study the transients in the magnetic signal on the order of 1% MR. These results lead to a model that describes magnetization configurations of the cluster of beads.
Performance Metrics and Measurements (2021)

This chapter discusses various metrics and measurement techniques discussed to inspect the communication system architecture and its performance. Signal quality estimation is by far the most important measure that can be used in adaptive systems. In addition to various measurements to identify the quality of the signal, visual graphs are also very useful to get insight on impairments and other disturbances impacting the signal. Constellation diagram can be obtained by plotting the imaginary versus the real part of the complex signal. Signal intelligence and generic signal analysis could be extremely important for testing software-defined radio transmitter, especially in doing government regulation, observing an operating network, qualification of a product, and to some extent R&D verification. Reference signal received power measurement, normally expressed in dBm, is utilized mainly to make ranking among different candidate cells in accordance with their signal strength.
Transmission Control in NB-IoT With Model-Based Reinforcement Learning (2023)

In Narrowband Internet of Things (NB-IoT), the control of uplink transmissions is a complex task involving device scheduling, resource allocation in the carrier, and the configuration of link-adaptation parameters. Existing heuristic proposals partially address the problem, but reinforcement learning (RL) seems to be the most effective approach a priori, given its success in similar control problems. However, the low sample efficiency of conventional (model-free) RL algorithms is an important limitation for their deployment in real systems. During their initial learning stages, RL agents need to explore the policy space selecting actions that are, in general, highly ineffective. In an NB-IoT access network this implies a disproportionate increase in transmission delays. In this paper, we make two contributions to enable the adoption of RL in NB-IoT: first, we present a multi-agent architecture based on the principle of task division. Second, we propose a new model-based RL algorithm for link adaptation characterized by its high sample efficiency. The combination of these two strategies results in an algorithm that, during the learning phase, is able to maintain the transmission delay in the order of hundreds of milliseconds, whereas model-free RL algorithms cause delays of up to several seconds. This allows our approach to be deployed, without prior training, in an operating NB-IoT network and learn to control it efficiently without degrading its performance.
Complex emission dynamics of type-II GaSb/GaAs quantum dots (2009)

Optical properties of the GaSb/GaAs quantum dot system are investigated using a time-resolved photoluminescence technique. In this type-II heterostructure the carriers of different species are spatially separated and, as a consequence, a smooth evolution of both the emission wavelength and decay timescale is observed. A wavelength shift of 170 nm is measured simultaneously with the progressive timescale change from 100 ps to 23 ns. These phenomena are explained by the evolution of the carrier density, which brings a modification to the optical transition probability as well as the shift in the emission toward the higher energies.
A Phase II Trial of Erlotinib in Combination with Bevacizumab in Patients with Metastatic Breast Cancer (2008)

The combination of erlotinib and bevacizumab was well-tolerated but had limited activity in unselected patients with previously treated MBC. Biomarkers are needed to identify those MBC patients likely to respond to anti-EGFR/HER1 plus anti-VEGF therapy.
Carbon-doped Ge2Sb2Te5 phase-change memory devices featuring reduced RESET current and power consumption (2012)

In this paper, carbon-doped Ge <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> Sb <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> Te <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</inf> , integrating from 5% to 15% of carbon content, is studied as an alternative phase-change material. Accurate electrical characterizations were performed both on large and shrinked PCM devices. Compared to pure Ge <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> Sb <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> Te <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</inf> based reference devices, a wide decrease of about 50% of the RESET current, which translates into a RESET power reduction of about 25%, is observed when 5% of carbon is added to Ge <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> Sb <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> Te <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</inf> . Moreover, an improved endurance up to 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">8</sup> cycles is obtained while maintaining a programming window higher than 2 orders of magnitude. An increase of about 30% of the activation energy for the crystallization process is also observed. Therefore, this paper suggests that Ge <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> Sb <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> Te <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</inf> doped with 5% of carbon is a promising phase-change material for future PCM technology.
Physicochemical and Pharmacokinetic Properties Determining Drug Detection in Skin (2021)

Abstract Chemicals, including some systemically administered xenobiotics and their biotransformations, can be detected noninvasively using skin swabs and untargeted metabolomics analysis. We sought to understand the principal drivers that determine whether a drug taken orally or systemically is likely to be observed on the epidermis by using a random forest classifier to predict which drugs would be detected on the skin. A variety of molecular descriptors describing calculated properties of drugs, such as measures of volume, electronegativity, bond energy, and electrotopology, were used to train the classifier. The mean area under the ROC curve was 0.71 for predicting drug detection on the epidermis, and the SHapley Additive exPlanations model interpretation technique was used to determine the most relevant molecular descriptors. Based on the analysis of 2,561 FDA approved drugs, we predict that therapeutic drug classes such as nervous system drugs are more likely to be detected on the skin. Detecting drugs and other chemicals noninvasively on the skin using untargeted metabolomics could be a useful clinical advancement in therapeutic drug monitoring, adherence, and health status.
Transurethral Prostate Ablation Using Saline-Liquid Electrode Introduced via Flexible Cystoscope (1998)

An interstitial saline-electrode has been developed to couple radiofrequency (RF) energy to prostate tissue in order to produce large lesions quickly and controllably. In this study, we attempted to produce similar results using a flexible catheter introduced transurethrally via a flexible cystoscope. An insulated 4F catheter with an extendable needle electrode (26-gauge, 5-mm exposed metal tip) was introduced through a port of a flexible cystoscope into the urethra of 10 dogs via a small perineal incision (required for the canine U-shaped urethra). Under visual endoscopic guidance, the electrode was placed in the center of the prostate and the needle electrode extended at an angle into the prostate, one lobe at a time. Hypertonic saline (14.6% NaCl) was infused at 2 mL/min through the needle electrode into the tissue for 30 seconds before and during RF application. The energy (50 W, 475 kHz) was delivered for 30, 45, 60, or 90 seconds (RFT System; U.S. Surgical Corporation). Prostate and urethral temperatures were monitored using thermocouples mounted on the catheter. There was an automatic high-temperature shut-off if the urethra reached >42 degrees C or if impedance reached >300 omega during RF energy application. Prostate sizes ranged from 1.4 x 2.0 x 1.4 cm to 5.0 x 4.5 x 4.2 cm. In this group, there were no automatic shut-offs at any of the energy durations, and the lesions produced ranged from 1.3 x 1.3 x 1.1 cm (0.99 cm3) to 1.6 x 2.7 x 2.2 cm (5.03 cm3). The average ablation volumes produced were 1.76 cm3 at 30 seconds' RF application, 2.42 cm3 at 45 seconds, 3.96 cm3 at 60 seconds, and 5.03 cm3 at 90 seconds. Histologic examination revealed typical coagulation necrosis in the treatment zone without tissue desiccation. Introduction of the saline-electrode through a flexible cystoscope provides a minimally invasive procedure that quickly and controllably produces large lesions that may provide effective treatment for benign prostatic hyperplasia with less patient discomfort.
Search for charged Higgs bosons decaying into a top quark and a bottom quark at $$ \sqrt{\mathrm{s}} $$ = 13 TeV with the ATLAS detector (2021)

A bstract A search for charged Higgs bosons decaying into a top quark and a bottom quark is presented. The data analysed correspond to 139 fb − 1 of proton-proton collisions at $$ \sqrt{s} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msqrt> <mml:mi>s</mml:mi> </mml:msqrt> </mml:math> = 13 TeV, recorded with the ATLAS detector at the LHC. The production of a heavy charged Higgs boson in association with a top quark and a bottom quark, pp → tbH + → tbtb , is explored in the H + mass range from 200 to 2000 GeV using final states with jets and one electron or muon. Events are categorised according to the multiplicity of jets and b -tagged jets, and multivariate analysis techniques are used to discriminate between signal and background events. No significant excess above the background-only hypothesis is observed and exclusion limits are derived for the production cross-section times branching ratio of a charged Higgs boson as a function of its mass; they range from 3.6 pb at 200 GeV to 0.036 pb at 2000 GeV at 95% confidence level. The results are interpreted in the hMSSM and $$ {M}_h^{125} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msubsup> <mml:mi>M</mml:mi> <mml:mi>h</mml:mi> <mml:mn>125</mml:mn> </mml:msubsup> </mml:math> scenarios.
Angiopoietin 1 causes vessel enlargement, without angiogenic sprouting,during a critical developmental period (2005)

Early in development, endothelial cells proliferate, coalesce, and sprout to form a primitive plexus of undifferentiated microvessels. Subsequently, this plexus remodels into a hierarchical network of different-sized vessels. Although the processes of proliferation and sprouting are well studied and are dependent on the angiogenic growth factor VEGF, the factors involved in subsequent vessel remodeling are poorly understood. Here, we show that angiopoietin 1 can induce circumferential vessel enlargement, specifically on the venous side of the circulation. This action is due to the ability of angiopoietin 1 to promote endothelial cell proliferation in the absence of angiogenic sprouting; vessel growth without sprouting has not been ascribed to other vascular growth factors, nor has specificity for a particular segment of the vasculature. Moreover, angiopoietin 1 potently mediates widespread vessel enlargement only during a brief postnatal period, in particular, prior to the fourth postnatal week, corresponding to stages in which VEGF inhibition causes widespread vessel regression. These findings show that angiopoietin 1 has a potentially unique role among the vascular growth factors by acting to enlarge blood vessels without inducing sprouting, and also define a critical window of vascular plasticity in neonatal development. Finding the key molecular factors that regulate this plasticity may prove crucial to the further development of pro- and anti-angiogenic therapies.
Efficient testing of SRAM with optimized march sequences and a novel DFT technique for emerging failures due to process variations (2005)

With increasing inter-die and intra-die parameter variations in sub-100-nm process technologies, new failure mechanisms are emerging in CMOS circuits. These failures lead to reduction in reliability of circuits, especially the area-constrained SRAM cells. In this paper, we have analyzed the emerging failure mechanisms in SRAM caches due to transistor V/sub t/ variations, which results from process variations. Also we have proposed solutions to detect those failures efficiently. In particular, in this work, SRAM failure mechanisms under transistor V/sub t/ variations are mapped to logic fault models. March test sequences have been optimized to address the emerging failure mechanisms with minimal overhead on test time. Moreover, we have proposed a design for test circuit to complement the March test sequence for at-speed testing of SRAMs. The proposed technique, referred as double sensing, can be used to test the stability of SRAM cells during read operations. Using the proposed March test sequence along with the double sensing technique, a test time reduction of 29% is achieved, compared to the existing test techniques with the same fault coverage. We have also demonstrated that double sensing can be used during SRAM normal operation for online detection and correction of any number of random read faults.
Queueing stability and CSI probing of a TDD wireless network with interference alignment (2015)

This paper characterizes the performance of IA technique taking into account the dynamic traffic pattern and the probing/feedback cost. We consider a TDD system where transmitters acquire their CSI (Channel State Information) by decoding the pilot sequences sent by the receivers. Since global CSI knowledge is required for IA, the transmitters have also to exchange their estimated CSIs over a backhaul of limited capacity. Under this setting, we characterize in this paper the stability region of the system and provide a probing algorithm that achieves the max stability region. In addition, we compare the stability region of IA to the one achieved by a TDMA system where each transmitter applies a simple ZF (Zero Forcing technique).
Combined Detection of Cancer Cells and a Tumor Biomarker using an Immunomagnetic Sensor for the Improvement of Prostate‐Cancer Diagnosis (2014)

Capture and detection of both a relevant antigen and cancer cells are demonstrated using magnetic graphene oxide (MGO) possessing conjugated antibodies. By simply dropping the MGO onto the surface of Pt electrodes while in a magnetic field, the sensor is rapidly constructed. The dual approach of the sensor potentially offers a more accurate, rapid platform than current tests based on immunological methods. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.