gebhart/patrepeval huggingface dataset:
Full-Duplex OFDMA Communications (2017)

In this chapter, we study the resource allocation and scheduling problem for a Full- Duplex (FD) Orthogonal Frequency-Division Multiple-Access (OFDMA) network where an FD Base Station (BS) simultaneously communicates with multiple pairs of UpLink (UL) and DownLink (DL) Half-Duplex (HD) users bidirectionally. We aim to find the optimal pairing of UL and DL users for each FD link and the allocation of the OFDM subcarriers and power to different pairs such that the sum rate of the network is maximized. This is a traditional combinatorial problem and the optimal approach requires an exhaustive search, which becomes prohibitively complicated as the number of users and subcarriers increase. In this chapter, we introduce two alternative ways of solving such a complex problem. In the first approach we formulate the problem as a mixed-integer nonlinear programming problem and solve it by using the dual method and Sequential Parametric Convex Approximation (SPCA). In the second approach, we introduce a low-complexity distributed approach based on matching theories and present an efficient near-optimal matching algorithm for resource allocation in FD-OFDMA systems.
Lecithinized superoxide dismutase promoted the recovery from spinal cord injury-induced motor dysfunction (2006)

PC-SOD (Lecithinized superoxide dismutase) is 4 molecules of a lecithin derivative-bound SOD, an enzyme of scavenging superoxide anion (O2-). Intravenous administration of PC-SOD (1 mg/kg) promoted the recovery from spinal cord injury (SCI)-induced motor dysfunction, when evaluated by BBB (Basso Beattie Bresnahan) score. The potency of PC-SOD was superior to that of methylprednisolone (MP) (30 mg/kg), which is now in clinical use. PC-SOD as well as MP inhibited SCI-induced neutrophil infiltration. The damaged area in PC-SOD treated spinal cord was less, as compared to that in MP-treated one. PC-SOD had only a little effect on gene expression of inflammatory cytokines and neurotrophic factors. However, MP suppressed not only gene expression but production. Different from MP, PC-SOD significantly promoted the production of GDNF. These data indicated that one reason why PC-SOD was superior might be ascribed partly to the increase of GDNF production.
The Pathfinder Vehicle Data Translator – Using Mobile Observations to Diagnose Road Weather Conditions (2012)

One solution for mitigating the impacts of weather on the transportation system is to provide improved hazard products to road maintenance operators and the travelling public. With funding and support from the U.S. Department of Transportation’s (USDOT) Research and Innovative Technology Administration (RITA) and direction from the Federal Highway Administration’s (FHWA) Road Weather Management Program, the National Center for Atmospheric Research (NCAR) is conducting research to develop a Vehicle Data Translator (VDT) that incorporates vehicle-based measurements of the road and surrounding atmosphere with traditional weather data sources, and creates road and atmospheric hazard products for a variety of users
Efficient light-driven CO2 hydrogenation on Ru/CeO2 catalysts (2018)

An efficient catalysis system for light-driven CO<sub>2</sub> hydrogenation was designed and the function mechanism of light was investigated.
Uterine contractions and the spread of local anesthetics in the epidural space. (1982)

Local anesthetics injected into the epidural space during a uterine contraction are commonly believed to produce a higher than usual level of anesthesia. This was evaluated in 34 parturients undergoing continuous lumbar epidural labor analgesia. The patients were divided into two equal groups. In group A, the inducing dose (2% chloroprocaine, 8 ml) was injected during an active uterine contraction and the top-up dose was injected between contractions. In group B, the injection sequence was reversed. Irrespective of the time of injection, in relation to uterine contractions, approximately 16 dermatomal segments were blocked in both groups. It is concluded that uterine contractions do not affect spread of local anesthetic solution in the epidural space.
Diastereoselective Synthesis of an Industrially Relevant 4-Aminopentanoic Acid by Asymmetric Catalytic Hydrogenation in a Biphasic System Using Aqueous Sodium Hydroxide as Substrate Phase (2016)

<i>A ’basic solution' for multiphase catalysis:</i> The diastereoselective synthesis of a pharmaceutically relevant 4-aminopentanoic acid derivative has been studied using a chiral homogeneous catalyst in tailored biphasic reaction media. Different polar solvents were investigated as the stationary phase for the well-established Ru–Mandyphos catalyst in combination with aqueous NaOH as the substrate and product phase. Facile product isolation and effective recycling of the catalyst phase were demonstrated at gram-scale. In particular, up to 3200 turnovers have been achieved in seven repetitive batches with a diastereoselectivity of 87–96% using [EMIM][NTf<sub>2</sub>]/NaOH<sub>aq</sub> as the biphasic system.
A Hydrophobic Cluster at the Surface of the Human Plasma Phospholipid Transfer Protein Is Critical for Activity on High Density Lipoproteins (2001)

The plasma phospholipid transfer protein (PLTP) belongs to the lipid transfer/lipopolysaccharide binding protein (LT/LBP) family, together with the cholesteryl ester transfer protein, the lipopolysaccharide binding protein (LBP) and the bactericidal permeability increasing protein (BPI). In the present study, we used the crystallographic data available for BPI to build a three-dimensional model for PLTP. Multiple sequence alignment suggested that, in PLTP, a cluster of hydrophobic residues substitutes for a cluster of positively charged residues found on the surface of LBP and BPI, which is critical for interaction with lipopolysaccharides. According to the PLTP model, these hydrophobic residues are situated on an exposed hydrophobic patch at the N-terminal tip of the molecule. To assess the role of this hydrophobic cluster for the functional activity of PLTP, single point alanine mutants were engineered. Phospholipid transfer from liposomes to high density lipoprotein (HDL) by the W91A, F92A, and F93A PLTP mutants was drastically reduced, whereas their transfer activity toward very low density lipoprotein and low density lipoprotein did not change. The HDL size conversion activity of the mutants was reduced to the same extent as the PLTP transfer activity toward HDL. Based on these results, we propose that a functional solvent-exposed hydrophobic cluster in the PLTP molecule specifically contributes to the PLTP transfer activity on HDL substrates.
IN-VIVO EVALUATION OF AN INTRAVENTRICULAR AXIAL FLOW BLOOD PUMP (IVAP) (1996)

Yamazaki, K.; Kormos, RL.; Antaki, JF.; Mori, T.*; Mukuo, H.; Kameneva, M.; Kerrigan, J.; Litwak, P.; Macha, M.; Watach, M.; Umezu, M.**; Tomioka, J.**; Griffith, BP.; Koyanagi, H.*** Author Information
Innovative wavelengths in endodontic treatment (2006)

The present study demonstrates that both wavelengths investigated could be suitable for the disinfection of even the deeper layers of dentin and equal the results achieved by established wavelengths in state-of-the-art endodontics.
ChemInform Abstract: Synthesis and Stereochemistry of Oxazolo(4′,5′:1,2)benz(5,4,3‐c,d) indole Derivatives as Intermediates on the Way to a Selective Dopamine Autoreceptor Agonist. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Potential antitumor agents. 45. Synthesis, DNA-binding interaction, and biological activity of triacridine derivatives (1986)

A series of amide-linked triacridines of varying interchromophore separation were synthesized as potential DNA trisintercalating agents. The corresponding diamide diacridines (lacking the central chromophore) were also prepared, and the DNA-binding and biological activities of both series of compounds were evaluated. Although one of the triacridines shows evidence of a trisintercalative binding mode, most of the triacridines (and all the diacridines) bound by bisintercalation. The diacridines showed great cytotoxicity and higher DNA association constants than the corresponding 9-[[3-(dimethylamino)propyl]amino]acridine monomer, but addition of a third chromophore did not provide corresponding increases in either DNA affinity, inhibition of RNA synthesis, or cytotoxicity. Some members of both series show minimal in vivo antileukemic activity. The results suggest that further development of trimeric molecules as potential antitumor agents should focus on smaller chromophores with lower capacity for nonspecific binding and/or the employment of rigid linker chains to provide true molecular "staples" for DNA.
Bonding Behavior of Porosity Inside Aluminum Alloy Die Castings through PRPC Process(<Special Issue>Solid Mechanics Indispensable for Automobile Engineering) (2009)

The existence of porosity in aluminum alloy die castings is unavoidable. If any porosity was left in the final products, there are harmful influences on the air leakage resistance and structural strength. The PRPC (Porosity Reducing Post Compression) process, by which the product is compressed under the remaining heat of the die casting, has been investigated to enhance the product reliability. In this study, the validity of PRPC was examined, mainly focused on the pore closure and bonding of the contact inner surfaces. The porosity inside die casting was observed non-destructively by using X-ray CT. The experimental procedures were as follows; (1) X-ray CT observation of aluminum alloy die castings specimens was carried out in initial state. (2) Compression load simulating the PRPC process was applied to the specimen at room temperature or high temperature. (3) X-ray CT observation was performed again. (4) Tension load was applied to examine the closing and bonding effect of PRPC process on the inner surface of porosity. (5) Re-open of the closed porosity was observed by X-ray CT after tension break. In the PRPC process under room temperature, the closure of porosity was possible, but the re-open of the porosity occurred by tension loading. However, In the PRPC process under high temperature, we could confirm that the bonding of porosity was possible without re-open after tension loading.
Analysis and Expression of the α-Expansin and β-Expansin Gene Families in Maize (2001)

Expansins comprise a multigene family of proteins in maize (Zea mays). We isolated and characterized 13 different maize expansin cDNAs, five of which are alpha-expansins and eight of which are beta-expansins. This paper presents an analysis of these 13 expansins, as well as an expression analysis by northern blotting with materials from young and mature maize plants. Some expansins were expressed in restricted regions, such as the beta-expansins ExpB1 (specifically expressed in maize pollen) and ExpB4 (expressed principally in young husks). Other expansins such as alpha-expansin Exp1 and beta-expansin ExpB2 were expressed in several organs. The expression of yet a third group was not detected in the selected organs and tissues. An analysis of expansin sequences from the maize expressed sequence tag collection is also presented. Our results indicate that expansin genes may have general, overlapping expression in some instances, whereas in other cases the expression may be highly specific and limited to a single organ or cell type. In contrast to the situation in Arabidopsis, beta-expansins in maize seem to be more numerous and more highly expressed than are alpha-expansins. The results support the concept that beta-expansins multiplied and evolved special functions in the grasses.
Effects of Current Density and Frequency on Microstructure and Mechanical Properties of Ni Stencil Masks Fabricated by Pulse Electroforming (2012)

We fabricated Ni stencil masks using a pulse electroforming and investigated the effects of current density and frequency on the microstructure and mechanical property. In the electroforming process, the current densities were 2.5 and 5 A/dm2 and the frequency varied from 0 (DC) to 1000 Hz at a duty cycle of 50%. Texture, microstructure, and mechanical properties varied with the current density and frequency. The preferred orientation of (220) at 2.5 A/dm2 changed to (200) as the current density increased to 5 A/dm2. Grain size decreased with decreasing current density or increasing frequency, probably due to a sufficient supply of Ni ions and the presence of inhibitor species. This decrease in grain size resulted in increase of hardness and wear resistance. However, with increase in current density and frequency (5 A/dm2 and 1000 Hz), the grain size became large, as a result of faradic current during the off-time.
Six-Year Outcomes of Anterior Lumbar Interbody Arthrodesis with Use of Interbody Fusion Cages and Recombinant Human Bone Morphogenetic Protein-2 (2009)

The use of dual tapered threaded fusion cages and recombinant human bone morphogenetic protein-2 on an absorbable collagen sponge obtained and maintained intervertebral spinal fusion, improved clinical outcomes, and reduced pain after anterior lumbar interbody arthrodesis in patients with degenerative lumbar disc disease.
Assembling highly repetitive Xanthomonas TALomes using Oxford Nanopore sequencing (2022)

Abstract Most plant-pathogenic Xanthomonas bacteria harbor transcription activator-like effector (TALE) genes, which function as transcriptional activators of host plant genes and support infection. The entire repertoire of up to 29 TALE genes of a Xanthomonas strain is also referred to as TALome. The DNA-binding domain of TALEs is comprised of highly conserved repeats and TALE genes often occur in gene clusters, which precludes the assembly of TALE-carrying Xanthomonas genomes based on standard sequencing approaches. Here, we report the successful assembly of the 5 Mbp genomes of five Xanthomonas strains from Oxford Nanopore Technologies (ONT) sequencing data. For one of these strains, Xanthomonas oryzae pv. oryzae ( Xoo ) PXO35, we illustrate why Illumina short reads and longer PacBio reads are insufficient to fully resolve the genome. While ONT reads are perfectly suited to yield highly contiguous genomes, they suffer from a specific error profile within homopolymers. To still yield complete and correct TALomes from ONT assemblies, we present a computational correction pipeline specifically tailored to TALE genes, which yields at least comparable accuracy as Illumina-based polishing. We further systematically assess the ONT-based pipeline for its multiplexing capacity and find that, combined with computational correction, the complete TALome of Xoo PXO35 could have been reconstructed from less than 20,000 ONT reads. Our results indicate that multiplexed ONT sequencing combined with a computational correction of TALE genes constitutes a highly capable tool for characterizing the TALomes of huge collections of Xanthomonas strains in the future.
Photoacoustic imaging of mesenchymal stem cells in living mice via silica-coated gold nanorods (2014)

Imaging is crucial for stem cell therapy to monitor the location(s), numbers, and state of the implanted cells. Real-time imaging in particular can ensure proper cell delivery for best engraftment. However, established imaging tools such as MRI are limited by their temporal resolution for guidance during delivery. In contrast, photoacoustic imaging is ideally suited for real time, image-guided therapy. Here, we use silica-coated gold nanorods as photoacoustic contrast agents and deploy them to image and quantitate mesenchymal stem cells during implant into the muscle tissue of live mice. Silica-coated gold nanorods (SiGNRs) were created with standard methods and loaded into mesenchymal stem cells (MSCs) without transfection agents. There was no significant (p&lt;0.05) toxicity or changes to cell proliferation after incubating MSCs with 0.05 nM SiGNRs for 3 hours. A panel of cytokines should only minor upregulation of inflammatory markers including interleukin-6. We used electron microscopy to illustrate vacuole-bound SiGNRs inside the cells. This cell staining increased photoacoustic signal 175% relative to MSCs without contrast agent—the silica coat itself increased signal 55% relative to uncoated GNRs. Using inductively coupled plasma spectroscopy, we found that there were 100,000 SiGNRs per MSC. This value was 5-fold higher than a MSC population stained with GNRs in the absence of silica coat. After labeling, cells were washed and injected into murine muscle tissue to simulate a muscular dystrophy patient. Mice (N=5) treated with these SiGNRlabeled MSCs exhibited no adverse events and implants up to 5 mm deep were easily visualized. The <i>in vivo</i> detection limit was 90,000 cells in a 100 uL bolus in mouse thigh muscle. Here, the B-mode signal is useful for orienting the treatment area and visualizing the delivery catheter while the photoacoustic mode offers cell-specific content. The photoacoustic signal was validated with histology a long-term fluorescent tracking dye after MSC transplant.
The proposal of national cancer prevention and screening programme (2004)

U radu je prikazan prijedlog nacionalnog programa prevencije i ranog otkrivanja raka dojke, debelog crijeva, vrata maternice i prostate.
Helicobacter pylori induced interleukin-8 expression in gastric epithelial cells is associated with CagA positive phenotype. (1995)

These results strongly support a role for H pylori CagA or coexpressed factors other than the cytotoxin in upregulation of gastric epithelial IL-8. Increased epithelial IL-8 secretion and concomitant neutrophil chemotaxis and activation in addition to direct cytotoxicity may be an important factor in tissue damage and ulceration.
Simulation-assisted building energy performance improvement using sensible control decisions (2011)

The building sector contributes significantly to global energy consumption and emission of greenhouse gases. Thermal insulation along with installation of energy-efficient building systems can reduce energy needs while preserving or improving occupant comfort levels. Still sensible control decisions, to harmoniously and effectively operate all building thermal systems, can be used to further improve building energy performance and/or thermal comfort. In this article, a simulation-assisted methodology is presented to automatically generate such decisions. There are two ingredients to our approach: a thermal simulation model --- a surrogate of the real building --- used to evaluate the effects of potential decisions; and, a cognitive adaptive optimization algorithm used to intelligently search for the "best" control decision. A user-defined cost function is used to compare various decision strategies. Corroborating simulation results are presented to quantify the expected benefits of the proposed approach.
In LipL32, the Major Leptospiral Lipoprotein, the C Terminus Is the Primary Immunogenic Domain and Mediates Interaction with Collagen IV and Plasma Fibronectin (2008)

LipL32 is the major leptospiral outer membrane lipoprotein expressed during infection and is the immunodominant antigen recognized during the humoral immune response to leptospirosis in humans. In this study, we investigated novel aspects of LipL32. In order to define the immunodominant domains(s) of the molecule, subfragments corresponding to the N-terminal, intermediate, and C-terminal portions of the LipL32 gene were cloned and the proteins were expressed and purified by metal affinity chromatography. Our immunoblot results indicate that the C-terminal and intermediate domains of LipL32 are recognized by sera of patients with laboratory-confirmed leptospirosis. An immunoglobulin M response was detected exclusively against the LipL32 C-terminal fragment in both the acute and convalescent phases of illness. We also evaluated the capacity of LipL32 to interact with extracellular matrix (ECM) components. Dose-dependent, specific binding of LipL32 to collagen type IV and plasma fibronectin was observed, and the binding capacity could be attributed to the C-terminal portion of this molecule. Both heparin and gelatin could inhibit LipL32 binding to fibronectin in a concentration-dependent manner, indicating that the 30-kDa heparin-binding and 45-kDa gelatin-binding domains of fibronectin are involved in this interaction. Taken together, our results provide evidence that the LipL32 C terminus is recognized early in the course of infection and is the domain responsible for mediating interaction with ECM proteins.
Improving Film Cooling Performance Using Airfoil Contouring (2008)

In this study, a computational fluid dynamics (CFD)-based optimization process is used to change the contour of the airfoil near a suction-side cooling hole in order to improve its film effectiveness characteristics. An overview of the optimization process, which includes automated geometry, grid generation, and CFD analyses, is provided. From the results for the optimized geometry, it is clear that the detachment of the cooling jet is much reduced and the cooling jet spread in the spanwise direction is increased substantially. The new external contour was then tested in a low-speed wind tunnel to provide a direct measure of the predictive capability. Comparisons to verification test data indicate that good agreement was achieved for both pressure and film cooling effectiveness behavior. This study proves that despite its limitations, current Reynolds averaged Navier-Stokes (RANS) methodology can be used a viable design tool and lead to innovative concepts for improving film cooling effectiveness.
Repair of Distal Biceps Tendon Ruptures Using a Combined Anatomic Interference Screw and Cortical Button (2005)

Mazzocca, Augustus D MD; Bicos, James MD; Arciero, Robert A MD; Romeo, Anthony A MD; Cohen, Mark S MD; Nicholson, Gregory MD Author Information
Experimental investigation of effects of flapping wing aspect ratio and flexibility on aerodynamic performance (2010)

In earlier studies, the optimal wing kinematics that gives the best aerodynamic performance was determined with a robotic flapper. The geometry and physical properties of wings are also critical for designing and fabricating Flapping Wing Micro Air Vehicles (FWMAVs). In this paper, the effects of wing aspect ratio and flexibility on aerodynamic performance are experimentally investigated to determine the optimal aspect ratio for Micro Air Vehicles (MAVs) wings at Reynolds number around 18,000. The comparison between the aerodynamic performance of rigid wings and flexible wings are also made whose veins are fabricated out of different materials.
A 90mW/GFlop 3.4GHz Reconfigurable Fused/Continuous Multiply-Accumulator for Floating-Point and Integer Operands in 65nm (2010)

This paper describes energy efficient and reconfigurable fused/continuous Multiply-Accumulator (MAC) architecture for single-precision Floating-point and 16-bit signed integer operands. This eight-stage pipelined and single-cycle throughput MAC design contains a bit level pipelined multiplier, followed by fast sparse-tree adder and single cycle accumulator loop with delayed normalization logic. Operation driven energy control is achieved using dynamic clock and fine grained power gating techniques. Power gating is employed in 98% of design to save 79% of leakage power in idle mode, at 1.2 V supply and 110 C. The use of fully shared logic in the multiplier, accumulator and normalization blocks for different operations enables a compact design of 0.54 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> containing 117 K transistors in eight-metal 65 nm CMOS technology. The 15-FO4 design provides 6.8 GFLOPS of performance with total energy efficiency of 90 mW/GFLOP at 1.2V and 3.4 GHz operation.