gebhart/patrepeval huggingface dataset:
Comparative study of navelbine(NVB) plus platinum protocol and cyclophosphamide,adriamycin and cisplatin protocol (CAP) for advanced non-small-cell lung cancer (2003)

Objective To compare the efficacy and toxicity of NVB plus platinum protocol with CAP protocol for advanced non-small-cell lung cancer.Methods The clinical data of 79 cases with advanced NSCLC treated with NVB plus platinum (27 cases) and CAP (22 cases) were analyzed.Results The response rate was 48.15% in patients treated with NVB plus platinum,and 36.36% in those with CAP,respectively.The major toxic reactions in the two chemotherapeutic protocols for the treatment of advanced NSCLC patients.Conclusion NVB plus platinum protocol is a effective and safe chemotherapeutic protocol for the treatment of advanced NSCLC.
3D Printing in The Chemical Industry (2018)

3D printing translates computer-aided design 3D models into physical objects in a layer-bylayer fashion. It enables designers to have fully functional prototype a few hours after the design is completed. A new industrial revolution is around the corner as commercial 3D printers become smaller, portable, and cheaper. Chemical companies must implement 3D printing as part of their overall digital transformation process. This paper provides a brief overview of using 3D printing in the chemical industry.
Characteristics of myopic traction maculopathy in myopic Singaporean adults (2020)

Our population-based study revealed that MTM was present in 0.9% of myopic eyes and 7.3% of highly myopic eyes. While greater myopic SE, longer AL, MMD and epiretinal traction are risk factors of MTM, age was not related to MTM. MTM has a negative effect on BCVA.
Myocardial Blood Flow Quantification From MRI by Deconvolution Using an Exponential Approximation Basis (2012)

We have evaluated the use of deconvolution using an exponential approximation basis for the quantification of myocardial blood flow from perfusion cardiovascular magnetic resonance. Our experiments, based on simulated signal intensity curves, phantom acquisitions, and clinical image data, indicate that exponential deconvolution allows for accurate quantification of myocardial blood flow. Together with automated respiratory motion correction myocardial contour delineation, the exponential deconvolution enables efficient and reproducible quantification of myocardial blood flow in clinical routine.
Eigenrhythms: Drum Track Bases (2004)

Describes the project on extracting the basic drum patterns from a large set of MIDI pop music renditions, and trying to describe them with a reduced-dimensional set of basis patterns. Includes some examples of basis functions derived from Independent Component Analysis, Linear Discriminant Analysis, and Nonnegative Matrix Factorization.
LINC00152 upregulates ZEB1 expression and enhances epithelial-mesenchymal transition and oxaliplatin resistance in esophageal cancer by interacting with EZH2 (2020)

Our study demonstrates that LINC00152/EZH2/ZEB1 axis can regulate EMT and resistance of EC cells to L-OHP, thus presenting a potential therapeutic target for EC treatment.
SynDEx-Mix: A hardware/software partitioning CAD tool (2014)

Real-time embedded applications require high computational performances. Mixed Architectures which contain programmable and reconfigurable parts may be the solution to meet this computational requirement. FPGA vendors start to sell such mixed architectures. But the implementation of an algorithm on these architectures lead to a huge number of possible implementations that had to be explored in order to reach real-time and resource minimization. Therefore, the use of a rapid prototyping methodology is required to automate the partitioning task and the code generation in order to reduce time to market. Consequently there is a great need for dedicated tools, covering simultaneously both programmable and reconfigurable components in a unified framework. Architecture Algorithm Adequation (AAA) is one of those rapid prototyping methodologies implemented in two differents tools targeting programmables components on the one hand, and reconfigurable components on the other hand. Since AAA does not support mixed architectures, this paper presents an extension of this methodology, and a new tool that couples SynDEx for programmable components and SynDEx-IC for reconfigurable components. This tool is called SynDEx-Mix.
Hazard Detection for Motorcycles via Accelerometers: A Self-Organizing Map Approach (2016)

This paper deals with collision and hazard detection for motorcycles via inertial measurements. For this kind of vehicles, the most difficult challenge is to distinguish road's anomalies from real hazards. This is usually done by setting absolute thresholds on the accelerometer measurements. These thresholds are heuristically tuned from expensive crash tests. This empirical method is expensive and not intuitive when the number of signals to deal with grows. We propose a method based on self-organized neural networks that can deal with a large number of inputs from different types of sensors. The method uses accelerometer and gyro measurements. The proposed approach is capable of recognizing dangerous conditions although no crash test is needed for training. The method is tested in a simulation environment; the comparison with a benchmark method shows the advantages of the proposed approach.
Realization and Characterization of Small Molecule Tandem Organic Solar Cells (2009)

The tandem solar cell concept is an approach to achieve power conversion efficiencies well above 10% with organic materials. The realization of such tandem organic solar cells contains several challenges concerning device architecture. The main issues are an optimization of the thin-film optics of such devices, the choice of adequate – preferably complementary – absorber materials, and an efficient electron-hole recombination contact between both subcells of a tandem solar cell. These issues, especially current matching through optical engineering of the stack, are systematically addressed in this paper. Furthermore, we discuss that the correct characterization of organic tandem cells is challenging and discuss the determination of the external quantum efficiency. The result of our studies is a tandem organic solar cell with 2 cm² active area and a certified efficiency of 6.07 %.
Longitudinal Control Of Heavy Duty Vehicles: Experimental Evaluation (1998)

This report describes the results of the first phase of the project, which was funded under MOU 293. These results consist of (i) improved modeling of air brakes for heavy trucks and buses, which accounts explicitly for nonlinearities and delays, and (ii) novel nonlinear algorithms for longitudinal control of commercial heavy vehicles without intervehicle communication. These algorithms use nonlinear spacing policies, backstepping control design, and aggressive prediction schemes to deal with the presence of significant delays and saturations in the fuel and brake actuators. As a result, their performance in the presence of delays is almost identical to the performance achieved in the absence of delays. This is the first class of algorithms which can deal with delays without relying on intervehicle communication, a property that was heretofore believed impossible to achieve. The significance of this result in terms of ITS deployment is that now we have removed one of the major obstacles to autonomous vehicle following for commercial heavy vehicles (CHVs). It also means that we can implement adaptive cruise control in trucks and buses that are not equipped with expensive brake-by-wire systems usually referred to as EBS (Electronic Brake Systems); this includes virtually every CHV on the road today, since EBS is only now starting to appear as an option on new trucks.
Abstract 4575: Covalent incorporation of a new class of dye-based affinity baits in sieving hydrogel nanoparticles overcome roadblocks to cancer biomarker discovery (2010)

Abstract Cancer biomarker discovery and clinical application has been seriously hampered by low abundance, instability and complex formation with high abundance proteins (e.g. albumin). N-isopropylacrylamide (NIPA) based hydrogel particles, consisting of a bait-containing core and a protective shell, overcome these major issues associated to biomarker discovery and measurement. Particles perform in one step, in solution, a) total sequestration and concentration, b) size sieving and c) complete protection form degradation of LMW protein biomarkers in blood and urine. In this study, novel dye molecules were selected as affinity ligands for broad classes of biomarkers; dyes were chosen for their ability to bind proteins, glycoproteins and nucleic acid for tissue histology, to bind textile proteins for fabric staining or for their known property to bind allergens. Dyes containing primary amine group (e.g. Acid Black 48, Basic Red 9) were coupled to NIPA/acrylic acid (AAc) particles by condensation of the amine group the carboxylic group. The ability of particles to capture and concentrate analytes was tested against a panel of low abundance, labile tumor relevant biomarker that include angiogenic growth factors (bFGF, VEGF, PDGF), IGF-1 and IGF binding proteins, interleukins (IL-6, IL-8), chemokines (CXCL12, CCL24), pro-apoptotic Bcl-2 proteins (Bak, Bax), and nucleic acids. Technologies used to screen dye functionalized particles include 1 D gel electrophoresis, western blotting, immunoassay, and mass spectrometry. Results showed that dye based baits have extremely high affinity for the target analytes so that particles capture all the analyte present in solution and that the affinity of biomarkers to the bait is unique and specific to the chemical structure of the bait molecule. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4575.
Aberrant expression of tumor suppressor proteins in the Ewing family of tumors. (2001)

Abrogation of the G1 checkpoint was common in this series of EFTs, and down-regulation of p21(WAF1) and p16(INK4a) were the most frequent findings. Loss of p16(INK4a) expression may identify a subset of cases with a more aggressive phenotype.
Plasma-Induced Exfoliation Provides Onion-Like Graphene-Surrounded MoS2 Nanosheets for a Highly Efficient Hydrogen Evolution Reaction (2020)

With the goal of obtaining sustainable earth-abundant electrocatalyst materials displaying high performance in the hydrogen evolution reaction (HER), here we propose a facile one-pot plasma-induced electrochemical process for the fabrication of new core-shell structures of ultrathin MoS<sub>2</sub> nanosheets engulfed within onion-like graphene nanosheets (OGNs@MoS<sub>2</sub>). The resultant OGNs@MoS<sub>2</sub> structures not only increased the number of active sites of the semiconducting MoS<sub>2</sub> nanosheets but also enhanced their conductivity. Our OGNs@MoS<sub>2</sub> composites exhibited high HER performance, characterized by a low overpotential of 118 mV at a current density of 10 mA cm<sup>-2</sup>, a Tafel slope of 73 mV dec<sup>-1</sup>, and long-time stability of 10<sup>5</sup> s without degradation; this performance is much better than that of the sheet-like graphene-wrapped MoS<sub>2</sub> composite GNs@MoS<sub>2</sub> (182 mV, 82 mV dec<sup>-1</sup>) and is among the best ever reported for composites involving MoS<sub>2</sub> and graphene nanosheets prepared through a simple one-batch process and using a low temperature and a short time for the HER. This approach appears to be an effective and simple strategy for tuning the morphologies of composites of graphene and transition metal dichalcogenide materials for a broad range of energy applications.
Reaction of polystyryllithium with tetrahydrofuran (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReaction of polystyryllithium with tetrahydrofuranCraig A. Ogle, Frederick H. Strickler, and Bernard Gordon IIICite this: Macromolecules 1993, 26, 21, 5803–5805Publication Date (Print):October 1, 1993Publication History Published online1 May 2002Published inissue 1 October 1993https://pubs.acs.org/doi/10.1021/ma00073a039https://doi.org/10.1021/ma00073a039research-articleACS PublicationsRequest reuse permissionsArticle Views108Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Features for Multiprocessing in SPUR Lisp (1988)

This paper describes simple extensions to Common Lisp for concurrent computation on multiprocessors. Functions for process creation, communication, and synchronization are described. Multiple threads of control are created with process objects. Communication and synchronization are managed using mailboxes. Signals provide asynchronous communication between processes. SPUR Lisp includes future and delay values, which were first introduced in Multilisp. These features provide a flexible and efficient basis on which higher-level multiprocessing abstractions can be implemented and studied
Anchor Placement on the Glenoid Faceplate Does Not Improve Stability With Bankart Repair (SS‐02) (2011)

Introduction Some surgeons recommend that suture anchors used during Bankart repair should be placed a few millimeters on the glenoid faceplate to enhance stability. However, there is risk with placing the anchors in this location due to the potential problem of anchor back‐out and early arthritis. Also, it has been suggested that a Bankart lesion should be repaired with a “bumper” of the capsulolabral tissue created to obtain a more stable shoulder. However, it has not been biomechanically determined that these techniques really improve stability. The purpose of this study was to determine 1) whether the shoulder would become stable by creating a “bumper,” and 2) whether placing the suture anchors on the glenoid faceplate would make the shoulder more stable. Methods Nine fresh‐frozen cadaveric shoulders (mean age, 75 years) were investigated. A custom testing machine with a six‐degree‐of‐freedom load‐cell was utilized. With a 50‐N axial force applied to the humerus, the humeral head was translated in the anterior direction and the peak translational force was measured at both the end‐range (60° of abduction relative to the scapula and maximum external rotation) and mid‐range (60° of abduction and neutral rotation) positions with the intact capsule, with a Bankart lesion, and after Bankart repair with and without a “bumper.” Bankart repair was performed at five different positions (glenoid rim, glenoid surface‐2 mm (2 mm inside from the glenoid rim), glenoid surface‐5 mm, scapular neck‐2 mm (2 mm medial on the scapular neck from the glenoid rim), and scapular neck‐5 mm). “Bumper” was created gathering up the capsule to form a thickened mass of tissue. Results The peak translational force which significantly decreased after creating a Bankart lesion returned to almost the intact condition level after Bankart repair at both arm positions. However, there were no significant differences between the forces after Bankart repair with and without the “bumper.” The force significantly decreased after scapular neck fixation‐2 mm and −5 mm compared to the one after glenoid rim fixation. However, there were no significant differences between the forces after glenoid rim fixation and glenoid surface fixation‐2 mm at both arm positions. On the other hand, the force significantly increased at the end‐range position and decreased at the mid‐range position after glenoid surface fixation‐5 mm. Conclusion Although some surgeons recommend that the suture anchors should be placed on the glenoid faceplate surface, our data showed that glenoid faceplate fixation did not make the shoulder more stable. The shoulder did not become more stable even after creating the “bumper.”
Effect of Product Inhibition on Xylose Fermentation to Ethanol by Saccharomyces cerevisae 424A (LNH-ST) (2011)

Commercially viable manufacturing of cellulosic ethanol requires high titers of product from both hexose and pentose fermentation. This article reports inhibition of initial specific xylose consumption rates and ethanol generation in batch fermentations of xylose using S. cerevisiae 424A (LNH-ST), a genetically modified strain capable of co-fermenting glucose and xylose. The fermentations were carried out in yeast extract peptone (YEP) medium in the presence of varying concentrations of ethanol (0% to 9% w/v) either added in a single dose or generated in situ by the yeast from glucose prior to xylose fermentation. The Levenspiel inhibition function was used to model inhibition of initial specific xylose consumption rates by ethanol. When ethanol was added in a single dose, the yeast ceased xylose fermentation when ethanol concentration reached 90 g L-1. However, when ethanol was generated in situ from glucose, the maximum final titer of ethanol was 110 g L-1. Comparing the effect of ethanol on xylose fermentation to the effect of ethanol on HXT transport of xylose in non-xylose-fermenting yeast suggests that inhibition of xylose transport into the cell is rate-limiting for fermentation.
Spin density wave and superconductivity in CaFe1−xCoxAsF studied by nuclear magnetic resonance (2012)

We performed nuclear magnetic resonance measurements to investigate the evolution of spin-density-wave (SDW) and superconducting (SC) states upon electron doping in CaFe${}_{1\ensuremath{-}x}$Co${}_{x}$AsF, which exhibits an intermediate phase diagram between those of LaFeAsO${}_{1\ensuremath{-}x}$F${}_{x}$ and Ba(Fe${}_{1\ensuremath{-}x}$Co${}_{x}$)${}_{2}$As${}_{2}$. We found that homogeneous coexistence of the incommensurate SDW and SC states occurs only in a narrow doping region around the crossover regime, which supports ${S}_{+\ensuremath{-}}$-wave symmetry. However, only the structural phase transition survives upon further doping, which agrees with predictions from orbital fluctuation theory. The transitional features upon electron doping imply that both spin and orbital fluctuations are involved in the superconducting mechanism.
CLINICAL TRIAL OF INTRAOPERATIVE RADIATION AND EXTERNAL-BEAM RADIATION COMBINED WITH TWICE-WEEKLY GEMCITABINE FOR THE TREATMENT OF LOCALLY ADVANCED PANCREATIC CANCER (2003)

s Submitted for the 68th Annual Scientific Meeting of the American College of Gastroenterology October 10-15, 2003, Baltimore, Maryland: PANCREATIC/BILIARY: PDF Only
MON-470 Pharmacological Inhibition of LAT1 Suppresses Proliferation and Hormone Synthesis in Rat Pituitary Tumor GH4 Cells [cc1] Synthesis May Be Better as Only mRNAs Were Measured (2019)

Pituitary tumors (PTs) occur in almost 17 % of the population and they represent about 10 % of all intracranial tumors. Growth hormone-producing pituitary tumors account for about 12% of pituitary tumors. At present, many patients with this type of pituitary tumor suffer from symptoms and complications caused by abnormal hormone production and/or mass effects due to limited treatment options. L-type amino acid transporter 1 (LAT1/SLC7A5) delivers essential amino acids into cells, and higher expression of LAT1 has been detected in various types of cancer including gliomas and pancreatic cancers. Furthermore, several lines of evidence suggest that blockade of LAT1 in tumor cells suppresses mammalian target of rapamycin complex (mTORC) 1 activity, resulting in either cell growth arrest or apoptotic cell death. However, LAT1 expression has not been elucidated in normal pituitary glands or PTs. In addition, the effects of LAT1 inhibition on cell growth and hormone synthesis in PTs also remain unknown. Here we show that LAT1, with expression comparable to LAT2, LAT3 and LAT4 in the normal mouse pituitary gland, is predominantly expressed in rat pituitary tumor GH4 cells, which secrete GH and PRL. An LAT1-specific inhibitor, JPH203, provided by J-Pharma Co., Ltd., Yokohama Japan, suppressed growth of these cells as well as GH and PRL synthesis. Water-Soluble Tetrazolium salt (WST)-8 assay revealed that effective doses of JPH203 on cell proliferation were ranging from 5 to 40 μM. Analyzing Annexin V-Fluorescein isothiocyanate (FITC) binding by flow cytometry, we found that JPH203 (40μM) induced apoptosis within three days and growth arrest for at least three weeks in GH4 cells. JPH203 also reduced the amount of GH and PRL mRNAs 40 % and 50 %, respectively. These results indicate that LAT1 is a potential target of therapy for pituitary tumors. Next, the mechanisms of JPH203 action in GH4 cells were investigated. Unexpectedly, JPH203 did not have any apparent effects on the phosphorylation state of mTOR1 and its downstream effectors. In contrast, rapamycin decreased phosphorylation levels of these proteins, resulting in a reduction in cell proliferation. Our findings suggest that in pituitary tumor cells there could be differential amino acid sensing pathways, which regulate both cell growth and hormone synthesis. Further studies will be required to determine the mechanism of action of the LAT1 inhibitor in GH4 cells.