gebhart/patrepeval huggingface dataset:
30 KDa phosphorylated form of Bcl-2 protein in human colon. (1996)

Bcl-2 expression was studied in a human colon cell line (HT-29) and in human colonic biopsies by Western and Northern blotting. Polyclonal antibodies raised against the Bcl-2 protein detected the expected 26 KDa protein in human colon. However, although Bcl-2 mRNA was present, the 26 KDa Bcl-2 protein was absent in HT-29 cells. Instead, a 30 KDa protein band strongly reacting with anti-Bcl-2 antibodies was found in HT-29 cells, and also in human colon, tonsil, and some other tissues. Alkaline phosphatase shifted the 30 KDa protein to the 26 KDa position in a time-dependent manner. 32P-labeling of HT-29 cells showed that the 30 KDa protein was phosphorylated. A 27 KDa phosphorylated protein was also immunoprecipitated by anti-Bcl-2 antibody. Phosphopeptide mapping showed that the 27 KDa protein contained a minimum of 3 and the 30 KDa protein at least an additional four phosphorylation sites. Phosphoamino acid analysis revealed that both the 30 KDa and 27 KDa proteins were phosphorylated on serine residues. These findings strongly suggest that the 30 KDa protein is a phosphorylated form of Bcl-2, which is widely distributed in human tissues.
Effect of cholestyramine resin on single dose valproate pharmacokinetics. (1996)

Cholestyramine, a nonabsorbable anion exchange resin, has been reported to bind concomitantly administered drugs and decrease their bioavailability. The objective of the study was to determine the effect of cholestyramine on the plasma concentrations of valproic acid (VPA) following concurrent and staggered (VPA 3 hours before cholestyramine) dosing. Six healthy volunteers participated in an open-label, 3-way crossover study. In each phase fasting subjects received 250 mg of VPA followed by serial blood sampling for VPA plasma concentrations over a 37-hour period. In the concurrent and staggered phase the subjects received 4 g of cholestyramine (CHOL) twice daily 24 hours prior to and following the VPA dose. During the concurrent phase the coadministration of CHOL resulted in a decrease (p < 0.05) in the area under the curve (AUC) for VPA compared to VPA alone (415.2 +/- 113.2 mg*hr/l vs 489.2 +/- 153.0 mg*hr/l, respectively). When the same dose of each drug was administered 3 hours apart, the AUC for VPA (454.8 +/- 123.1 mg*hr/l) was not significantly decreased when compared to VPA alone (489.2 +/- 153.0 mg*hr/l). Also, the bioavailability relative to VPA alone was 86.2% +/- 7.1 for the concurrent phase and 95.3% +/- 13.6 for the staggered phase. Based on the AUC of VPA concurrent administration of CHOL significantly decreases VPA absorption and separating the doses of the 2 drugs by 3 hours may lessen the interaction.
Bi-directionady motion-compensated frame-rate up-conversion for H.264/AVC decoders (2005)

We propose a technique to perform frame-rate up-conversion in baseline H.264/AVC compliant decoders. It exploits a low-complexity motion estimation algorithm including a novel method to enhance the consistency of motion fields. The final interpolation through adaptive median filtering provides excellent results in terms of objective and subjective visual quality
P15.05: Ultrasound features of an anomaly of the umbilico-portal system-a case report (2009)

Examination of the fetal venous system plays an important role in fetal anomaly screening. About 20–30% of the oxygenated blood from the placenta is transported from the umbilical vein (UV) through the ductus venosus (DV) into the inferior vena cava (IVC), through the foramen ovale directly into the left heart. Abnormalities of the umbilico-portal system have been reported to be associated with cardiac anomalies, cardiac failure and fetal hydrops. We present a report of such a case. Mdm IBM is 33 year-old, G5, P4 had a screening scan at 20 weeks that showed an unusual course of UV, traversing anteriorly and superiorly with the (R) & (L) portal veins branching at the same level. The typical DV segment which is supposed to arise from the portal sinus is not seen at its usual site. Instead, a long and dilated segment with biphasic flow on Doppler is seen. This drains into the (R) atrium. No cardiomegaly or dilated IVC was noted. Serial ultrasound examinations were performed to detect early hydrops and cardiomegaly, which were absent. Karyotype was normal, 46,XX. Baby was delivered at 37 weeks. Postnatally baby is well. 2D echocardiography showed small to moderate VSD (ventricular septal defect) 3.4mm. Abdominal ultrasound showed a thrombosed proximal UV, and the distal UV had abnormal communications with both right and left portal veins. There is portal venous flow demonstrated from the portal veins into a shunt (continuation of UV) which later drains superiorly into the left hepatic vein. Hospital birth defect database was searched. 3 cases of fetuses with ductus venosus anomalies different from the above case described were found. All 3 cases were absent ductus venosus. This is an unusual case of abnormal umbilico-portal venous circulation which was prenatally detected on routine screening scan. Follow-up monitoring did not show any features of cardiac failure.
Novel ESD-suppressing material: Voltage-dependent resistor (VDR) resin with ZnO-based ceramic fillers (2016)

This paper presents a novel encapsulation resin that can relieve the impact of electrostatic discharge (ESD) on electronic devices. The encapsulation resin employs ZnO-based ceramic varistor particles instead of SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> fillers. It shows a typical voltage-dependent resistance (VDR) property, i.e., steep resistance drop with the rise of applied voltage. To adopt the resin (hereinafter referred to as the VDR resin) as an ESD-suppressing material, the VDR resin itself has to possess sufficiently strong ESD immunity. Prior to improvement, the VDR resin brought about short-circuit failure in the case that the human-body model (HBM) ESD of 4 kV or more was applied. Cross-sectional analysis indicated it was caused by delamination and damaged layer at the interface between matrix polymer and varistor particle. The matrix polymer's dielectric constant showed strong dependence on ESD immunity of VDR resin, i.e., the lower the better. The optimized VDR resin had an excellent VDR property, ESD immunity, and reliability. The ability of the optimized VDR resin to protect electronic devices, namely, CSP-LEDs, from ESD was demonstrated.
Automated Remote Monitoring for Peritoneal Dialysis and Its Impact on Blood Pressure (2020)

This study showed that treatment adherence and ultrafiltration amounts of patients increased with the use of RM-APD, as well as better blood pressure control with fewer antihypertensive drugs.
Magnetostriction and magnetostrictivite effects in magnetic materials (1978)

Most magnetic materials undergo a spontaneous deformation due to magnetostriction. In any non-uniformly magnetized sample, this effect gives rise to internal stresses and lattice rotations. They were studied within the framework of infinitesimal dislocation theory. A magnetic wall may thus be represented by densities of infinitesimal quasi-dislocations located on the wall and a wall junction by a quasi-disclination (rotation dislocation) located along the junction. In the case of simple magnetic configurations, semiquantitative arguments suffice to compare experimental results obtained by means of X-ray topography with theoretical expectations. The agreement is good on the whole. For more complex configurations, X-ray topograph image simulation is required and partial results obtained in the case of a Dijkstra and Martius structure are presented.
Supplementary Table S1 from Safety, Outcomes, and T-Cell Characteristics in Patients with Relapsed or Refractory MDS or CMML Treated with Atezolizumab in Combination with Guadecitabine (2023)

&lt;p&gt;Specific genes sequenced in bone marrow mononuclear cells.&lt;/p&gt;
Contact resistance of low-voltage n-channel organic thin-film transistors based on perylene-diimide and tetraazaperopyrene derivatives (2020)

The characteristics of low-voltage n-channel organic thin-film transistors (TFTs) based on the small-molecule semiconductors N,N’-bis(2,2,3,3,4,4,4-fluorobutyl)-(1,7 &amp; 1,6)-dicyano-perylene-tetracarboxylic diimide (ActivInk N1100) and 2,9-bis(heptafluoropropyl)-4,7,11,14-tetrabromo-1,3,8,10-tetraazaperopyrene (TAPP) are compared. Staggered and coplanar TFTs were fabricated, and all measurements were performed in ambient air. In the coplanar TFTs, the source and drain contacts were treated with one of three different thiols. Overall, the two semiconductors provide similar performance, with electron mobilities up to 0.15 cm2/Vs, on/off ratios up to five orders of magnitude, subthreshold slopes as small as 130 mV/decade and contact resistances (measured using the transmission line method) as small as 21 kOhm-cm.
Search for resonant WZ production in the WZ→lνl′l′ channel in √(s)=7 TeV pp collisions with the ATLAS detector (2012)

A generic search is presented for a heavy particle decaying to WZ → ℓν′ ℓ ′ (ℓ, ℓ′ = e, μ)final states. The data were recorded by the ATLAS detector in ffiffiffis √ s = 7 TeV pp collisions at the Large Hadron Collider and correspond to an integrated luminosity of 1:02 fb-1. The transverse mass distribution of the selected WZ candidates is found to be consistent with the standard model expectation. Upper limits on the production cross section times branching ratio are derived using two benchmark models predicting a heavy particle decaying to a WZ pair.
Metastable-atom-activated growth of an ultrathin carbonaceous resist for reactive ion etching of SiO2 and Si3N4 (1998)

A thin carbonaceous resist was grown by exposing a substrate to a beam of neutral metastable argon atoms in the presence of siloxane vapor. X-ray photoelectron spectroscopy and Auger electron spectroscopy data show that the resist was composed primarily of carbon. Near edge x-ray absorption fine structure spectra of samples exposed to metastable atoms show that carbon double bonds were formed during exposure. The deposited material was used as a resist for reactive ion etching into SiO2 and Si3N4. Lines in SiO2 were fabricated with widths as small as 20 nm, aspect ratios &amp;gt;2:1, and sidewalls as steep as 7:1.
ChemInform Abstract: A Ruthenium‐Catalyzed Pyrrolidine and Piperidine Synthesis. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The Autonomous Siemens Tram (2020)

This paper presents the Autonomous Siemens Tram that was publicly demonstrated in Potsdam, Germany during the InnoTrans 2018 exhibition. The system was built on a Siemens Combino tram and used a multi-modal sensor suite to localize the vehicle, and to detect and respond to traffic signals and obstacles. An overview of the hardware and the developed localization, signal handling, and obstacle handling components is presented, along with a summary of their performance.
Control of VP16 Translation by the Herpes Simplex Virus Type 1 Immediate-Early Protein ICP27 (2005)

Herpes simplex virus (HSV) ICP27 is an essential and multifunctional regulator of gene expression that modulates the synthesis and maturation of viral and cellular mRNAs. Processes that are affected by ICP27 include transcription, pre-mRNA splicing, polyadenylation, and nuclear RNA export. We have examined how ICP27 influences the expression of the essential HSV tegument protein and transactivator of immediate-early gene expression VP16. We monitored the effects of ICP27 on the levels, nuclear export, and polyribosomal association of VP16 mRNA and on the amount and stability of VP16 protein. Deletion of ICP27 reduced the levels of VP16 mRNA without altering its nuclear export or the stability of the encoded protein. However, the translational yield of the VP16 mRNA produced in the absence of ICP27 was reduced 9- to 80-fold relative to that for wild-type infection, suggesting a defect in translation. In the absence of ICP27, the majority of cytoplasmic VP16 mRNA was not associated with actively translating polyribosomes but instead cosedimented with 40S ribosomal subunits, indicating that the translational defect is likely at the level of initiation. These effects were mRNA specific, as polyribosomal analysis of two cellular transcripts (glyceraldehyde-3-phosphate dehydrogenase and beta-actin) and two early HSV transcripts (thymidine kinase and ICP8) indicated that ICP27 is not required for efficient translation of these mRNAs. Thus, we have uncovered a novel mRNA-specific translational regulatory function of ICP27.
Abstract 342: Analysis of Mechanism of a Novel Drug Candidate using an Organ-level Functional Microdevice that Reconstitutes Human Pulmonary Thrombosis (2016)

Pulmonary microvascular thrombosis is a catastrophic medical condition and yet, it is very difficult to predict response and study mechanism of action of potential drug candidates to humans. This is partly so because currently available in vitro assays do not recapitulate physiologically-relevant forces and animal models can also be very complex, making it impossible to analyze intercellular signaling within the lung that occurs under coagulation or drug administration. We designed a model of lung thrombosis in which human primary alveolar and endothelial cells are co-cultured and maintained up to 2 weeks. The device consists of a top chamber seeded with human alveolar epithelial cells (AE) and a lower chamber seeded with endothelial cells, separated by a porous matrix-coated membrane. Whole blood was perfused at a physiological shear stress through the vascular channel and clots were visualized in real-time. When healthy cells were cultured, no intravascular blood clotting was observed, even when lipopolysaccharide (LPS) endotoxin was administered. In contrast, when LPS was added to the AE channel, it caused a significant increase in platelet adhesion at the endothelium, demonstrating that the presence of alveolar epithelium is critical to LPS-induced intravascular thrombosis in vitro . We evaluated this device by analyzing a novel protease activator receptor-1 (PAR1) antithrombotic compound, termed parmodulin 2 (PM2). When the endothelium was cultured along with PM2 under the condition of LPS stimulated AE, we found inhibition of clotting, demonstrating the therapeutic effect of PM2 in the presence of epithelial-endothelial-blood cell signaling. Finally, to test if PM2 performs the therapeutic function of Activated Protein C (APC) that has been reported to stimulate its cytosolic effects via the β-arrestin pathway, we knocked down β-arrestin in the endothelium and analyzed clot formation again. We found that clotting reoccurred in vascular channel, thus showing that PM2 acts like an APC-like drug candidate. In conclusion, the lung alveolus-on-a-chip reconstitutes organ-level responses to blood clotting and may offer a valuable platform for drug development by allowing to dissect contributions of various cells in their mechanism of action.
The foundations of learning - A fresh perspective on common coaching methodologies (2015)

&#x0D; &#x0D; &#x0D; Preparing players for elite competition requires a commitment to ongoing training and competition, both of which are underpinned by the knowledge a player has of the techniques/tactics necessary for success. The manner in which we teach these skills is crucial in determining the likely outcome when a player is tested under competition conditions. “Simplicity is the ultimate sophistication” Leonardo Da Vinci.&#x0D; &#x0D; &#x0D;
Porous Polymers. Herausgegeben von Michael S. Silverstein, Neil R. Cameron und Marc A. Hillmyer. (2011)

John Wiley & Sons, Hoboken, 2011. 472 S., geb., 109.00 €.—ISBN 978-0470390849
Self-similarity and finite-size effects in nano-indentation of highly cross-linked polymers (2008)

The scalability of thermomechanical polymer deformations in the sub-10 nm regime is of particular importance for nano-imprint techniques, hardness measurements of thin films by nano-indentations, and scanning-probe-based thermomechanical data storage. We investigate nano-indentation in the sub-10 nm regime performed on highly cross-linked polymer films of different thicknesses. It is shown that the lateral and vertical geometric characteristics of the indents independently scale down to an indent depth of 1 nm and that the scaling parameters are functions of the film thickness and the temperature of the indenter. However, in the limit of shallow indents the scaling of the cross-coupling between lateral and vertical dimensions is lost. It is argued that the breakdown of self-similarity is due to a minimum strain requirement originating from the co-operative nature of the polymer response induced by α transitions which lock the indent in the deformed state. The results shed new light on the fundamental processes and size effects involved in nanoscale plastic replication, in general.
Highly piezoelectric co-doped AlN thin films for bulk acoustic wave resonators (2013)

In this paper, the piezoelectric properties of Mg and Zr co-doped AlN (MgZr doped AlN) thin films are reported. MgZr doped AlN thin films were prepared on Si (100) substrates with a radio frequency magnetron reactive cosputtering system. The crystal structures and piezoelectric constants d <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">33</sub> of the films were investigated as a function of their concentrations, which was measured by X-ray diffraction and with a piezometer. The d <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">33</sub> of the MgZr doped AlN at total Mg and Zr concentrations of 35 atomic % was about three times larger than that of pure AlN. The experimental results of the crystal structure and d <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">33</sub> as a function of total Mg and Zr concentrations were in very close agreement with first-principle calculations. Finally, thin film bulk acoustic wave resonators (FBARs) that used MgZr doped AlN as a piezoelectric thin film were fabricated and compared with the AlN based FBAR. As a result, the electromechanical coupling coefficient improved from 7.1 to 8.5% with the Mg and Zr concentration at 13atomic % doped into AlN. The results from this study suggest that the MgZr doped AlN films have potential as a piezoelectric thin film for wide band and high frequency RF applications.
A Spontaneous Isolated Superior Mesenteric Artery Dissection Associated with Cocaine Abuse: A Pathomechanistic Association (2020)

Spontaneous isolated superior mesenteric artery dissection (SISMAD) is a rare potentially fatal disease. We present a case of cocaine-related SISMAD in a patient with abdominal pain. A 38-year-old African American male with hypertension and alcohol, cocaine, and tobacco abuse presented with abdominal pain and recent cocaine use. A CT angiogram revealed SISMAD; he was treated with conservative management. Cocaine and SISMAD share similar pathophysiologic mechanisms pertaining to vascular smooth muscle cell apoptosis and increased shear stress at fixed vascular positions. Our report emphasizes the need to consider cocaine abuse in SISMAD pathophysiology, risk stratification, and treatment algorithms in future studies.
Succinate production in Escherichia coli (2011)

Succinate has been recognized as an important platform chemical that can be produced from biomass. While a number of organisms are capable of succinate production naturally, this review focuses on the engineering of Escherichia coli for the production of four-carbon dicarboxylic acid. Important features of a succinate production system are to achieve an optimal balance of reducing equivalents generated by consumption of the feedstock, while maximizing the amount of carbon channeled into the product. Aerobic and anaerobic production strains have been developed and applied to production from glucose and other abundant carbon sources. Metabolic engineering methods and strain evolution have been used and supplemented by the recent application of systems biology and in silico modeling tools to construct optimal production strains. The metabolic capacity of the production strain, the requirement for efficient recovery of succinate, and the reliability of the performance under scaleup are important in the overall process. The costs of the overall biorefinery-compatible process will determine the economic commercialization of succinate and its impact in larger chemical markets.
Characterization of wafer bonded photodetectors fabricated using various annealing temperatures and ambients (1997)

A detailed study of the important role of temperature and gas ambient on the bonding between Si and InGaAs wafers was performed. The heterointerface was characterized by fabricating p-i-n photodetectors and measuring the forward and reverse currents, the capacitance, the absolute quantum efficiency, and the response bandwidth. Clear evidence for a thin tunneling barrier is found for nonoptimum fusing conditions.
Modulus of three and four functional poly(dimethylsiloxane) networks (1981)

Networks formed from ci, w divinyl poly(dimethylsiloxane) end- linked with tn-and tetrafunctional hydrosilanes are used to test several theoretical relations for the small strain modulus. The results indicate that topological interactions between chains have a large influence on the modulus, however, the suppression of junction fluctuation by topological interactions seems to be small for PDMS networks. Independent measurement of the topological interactions between chains, the plateau modulus G on linear PDMS, agrees well with that determined from the networks. The influence of hydrosilane side reactions on determination of network structure parameters was accounted for.
Rapid activation and partial inactivation of inositol trisphosphate receptors by adenophostin A (2000)

Adenophostin A, the most potent known agonist of inositol 1,4,5-trisphosphate (InsP3) receptors, stimulated 45Ca2+ release from the intracellular stores of permeabilized hepatocytes. The concentration of adenophostin A causing the half-maximal effect (EC50) was 7.1±0.5nM, whereas the EC50 for InsP3 was 177±26nM; both responses were positively co-operative. In rapid superfusion analyses of 45Ca2+ release from the intracellular stores of immobilized hepatocytes, maximal concentrations of adenophostin A or InsP3 evoked indistinguishable patterns of Ca2+ release. The Ca2+ release evoked by both agonists peaked at the same maximal rate after about 375ms and the activity of the receptors then decayed to a stable, partially (60%) inactivated state with a half-time (t1/2) of 318±29ms for adenophostin A and 321±22ms for InsP3. Dissociation rates were measured by recording rates of InsP3-receptor channel closure after rapid removal of agonist. The rate of adenophostin A dissociation (t1/2, 840±195ms) was only 2-fold slower than that of InsP3 (t1/2, 436±48ms). We conclude that slow dissociation of adenophostin A from InsP3 receptors does not underlie either its high-affinity binding or the reported differences in the Ca2+ signals evoked by InsP3 and adenophostin A in intact cells.