gebhart/patrepeval huggingface dataset:
Aluminum-Induced Photoluminescence Red Shifts in Core–Shell GaAs/AlxGa1–xAs Nanowires (2013)

We report a new phenomenon related to Al-induced carrier confinement at the interface in core-shell GaAs/Al(x)Ga(1-x)As nanowires grown using metal-organic vapor phase epitaxy with Au as catalyst. All Al(x)Ga(1-x)As shells strongly passivated the GaAs nanowires, but surprisingly the peak photoluminescence (PL) position and the intensity from the core were found to be a strong function of Al composition in the shell at low temperatures. Large and systematic red shifts of up to ~66 nm and broadening in the PL emission from the GaAs core were observed when the Al composition in the shell exceeded 3%. On the contrary, the phenomenon was observed to be considerably weaker at the room temperature. Cross-sectional transmission electron microscopy reveals Al segregation in the shell along six Al-rich radial bands displaying a 3-fold symmetry. Time-resolved PL measurements suggest the presence of indirect electron-hole transitions at the interface at higher Al composition. We discuss all possibilities including a simple shell-core-shell model using simulations where the density of interface traps increases with the Al content, thus creating a strong local electron confinement. The carrier confinement at the interface is most likely related to Al inhomogeneity and/or Al-induced traps. Our results suggest that a low Al composition in the shell is desirable in order to achieve ideal passivation in GaAs nanowires.
Large tunnel magnetoresistance in Co2FeAl0.5Si0.5∕MgO∕Co2FeAl0.5Si0.5 magnetic tunnel junctions prepared on thermally oxidized Si substrates with MgO buffer (2008)

Magnetic tunnel junctions (MTJs) using polycrystalline Co2FeAl0.5Si0.5 (CFAS) electrodes with a MgO tunnel barrier were fabricated onto thermally oxidized Si substrates. Highly (001)-oriented and B2-ordered CFAS electrodes were obtained by optimizing growth conditions and postannealing temperature. The microfabricated MTJs exhibited relatively high tunnel magnetoresistance (TMR) ratios of 125% at room temperature and 196% at 7K. The large TMR obtained using oxidized Si substrates indicates that CFAS is promising for the practical applications.
Eye Lens Dosimetry in Interventional Radiology: Assessment With Dedicated Hp(3) Dosimeters (2020)

Full-time interventional radiologists are likely to suffer from deterministic radiation effects to the eye lens, especially on the left side. Neck TLD significantly overestimates eye lens dose. However, eye lens doses are highly correlated with neck doses and may be predicted from the neck TLD values.
Congenital Hypomyelinating Neuropathy with Lethal Conduction Failure in Mice Carrying the Egr2 I268N Mutation (2009)

Mouse models of human disease are helpful for understanding the pathogenesis of the disorder and ultimately for testing potential therapeutic agents. Here, we describe the engineering and characterization of a mouse carrying the I268N mutation in Egr2, observed in patients with recessively inherited Charcot-Marie-Tooth (CMT) disease type 4E, which is predicted to alter the ability of Egr2 to interact with the Nab transcriptional coregulatory proteins. Mice homozygous for Egr2(I268N) develop a congenital hypomyelinating neuropathy similar to their human counterparts. Egr2(I268N) is expressed at normal levels in developing nerve but is unable to interact with Nab proteins or to properly activate transcription of target genes critical for proper peripheral myelin development. Interestingly, Egr2(I268N/I268N) mutant mice maintain normal weight and have only mild tremor until 2 weeks after birth, at which point they rapidly develop worsening weakness and uniformly die within several days. Nerve electrophysiology revealed conduction block, and neuromuscular junctions showed marked terminal sprouting similar to that seen in animals with pharmacologically induced blockade of action potentials or neuromuscular transmission. These studies describe a unique animal model of CMT, whereby weakness is due to conduction block or neuromuscular junction failure rather than secondary axon loss and demonstrate that the Egr2-Nab complex is critical for proper peripheral nerve myelination.
Interoperability and coexistence (2013)

The 802.11n amendment introduced many optional features and the 802.11ac amendment introduces a few more. These optional features are geared toward specific market segments that will likely only be deployed in specific classes of devices. Many of the optional features are complex and, given time to market concerns and cost constraints, many implementations will only adopt a subset of the available features, perhaps phasing in features with time or in higher end products. Some features appear in multiple flavors. This is due to the many unknowns present at the time the features were being discussed during the standard development process. Very often there was no single clear direction to take that would clearly suit all situations and so variations were introduced.
Experimental investigation of right‐left flow balance concepts for a total artificial heart (2020)

A total artificial heart (TAH) must be designed to autonomously balance the flows of the systemic and pulmonary circulation to prevent potentially lethal lung damage. The flow difference between the systemic and pulmonary circulation is mainly caused by the bronchial (arteries) shunt flow and can change dynamically. The ReinHeart TAH consists of only one actuator that ejects blood alternately from the right and left pump chamber. This design entails a coupling of the right and left stroke and thus, complicates the independent adaptation of the right and left flow. In this experimental study on the ReinHeart TAH, four concepts to keep the flows well balanced were investigated using an active mock circulation loop for data acquisition. Three concepts are based on mechanical design changes (variation of pusher plate shape, flexible right pump chamber housing, and reduced right stroke volume) to achieve a static flow difference. In combination with these static concepts, a concept influencing the ratio of systole and diastole duration to respond to dynamic changes was studied. In total, four measurement series, each with 270 operating points, to investigate the influence of circulatory filling volume, heart rate, bronchial shunt flow, and lung resistance were recorded. In the course of this study, we introduce a concept deviation indicator, providing information about the efficiency of the concepts to balance the flows based on changes in lung's blood pressures. Furthermore, the distribution of the measured data was evaluated based on bubble plot visualizations. The investigated variation of the right pusher plate shape results in high lung pressures which will cause lethal lung damage. In comparison, a flexible right pump chamber housing shows lower lung pressures, but it still has the potential to damage the lungs. Reducing the stroke volume of the right pump chamber results in proper lung pressures. The flow balance can dynamically be influenced with a positive effect on the lung pressures by choosing a suitable systole-diastole-ratio. The results of this study suggest that an adequate right-left flow balance can be achieved by combining the mechanical concept of a reduced right stroke volume with an active control of the systole-diastole-ratio.
Effects of biphasic and monophasic electrical stimulation on mitochondrial dynamics, cell apoptosis, and cell proliferation (2018)

Currently, electrical stimulation (ES) is used to induce changes in various tissues and cellular processes, but its effects on mitochondrial dynamics and mechanisms are unknown. The aim of this study was to compare the effects of monophasic and biphasic, anodal, and cathodal ES on apoptosis, proliferation, and mitochondrial dynamics in neuroblastoma SH-SY5Y cells. Cells were cultured and treated with ES. Alamar blue assay was performed to measure cell proliferation. The proteins expression of apoptotic-related proteins Bcl-2 associated X (Bax), B cell lymphoma 2 (Bcl-2), optic-atrophy-1 (OPA1), mitofusin2 (Mfn2), phosphorylated dynamin-related protein 1 at serine 616 (p-DRP1), and total dynamin-related protein 1 (Total-DRP1) were also determined. The results showed that monophasic anodal and biphasic anodal/cathodal (Bi Anod) ES for 1 hr at 125 pulses per minute (2.0 Hz) produced the most significant increase in cell proliferation. In addition, monophasic anodal and Bi Anod ES treated cells displayed a significant increase in the levels of anti-apoptotic protein Bcl-2, whereas the Bax levels were not changed. Moreover, the levels of Mfn2 were increased in the cells treated by Bi Anod, and OPA1 was increased by monophasic anodal and Bi Anod ES, indicating increased mitochondrial fusion in these ES-treated cells. However, the levels of mitochondrial fission indicated by DRP1 remained unchanged compared with non-stimulated cells. These findings were confirmed through visualization of mitochondria using Mitotracker Deep Red, demonstrating that monophasic anodal and Bi Anod ES could induce pro-survival effects in SH-SY5Y cells through increasing cell proliferation and mitochondrial fusion. Future research is needed to validate these findings for the clinical application of monophasic anodal and Bi Anod ES.
Adult neurogenesis in mammals (2019)

Neurogenesis in adulthood has implications for sense of self, memory, and disease
Assembly of biomimetic microreactors using caged-coacervate droplets (2022)

Complex coacervates are liquid-like droplets that can be used to create adaptive cell-like compartments. These compartments offer a versatile platform for the construction of bioreactors inspired by living cells. However, the lack of a membrane significantly reduces the colloidal stability of coacervates in terms of fusion and surface wetting, which limits their suitability as compartments. Here, we describe the formation of caged-coacervates surrounded by a semipermeable shell of silica nanocapsules. We demonstrate that the silica nanocapsules create a protective shell that also regulates the molecular transport of water-soluble compounds as a function of nanocapasule size. The adjustable semipermeability and intrinsic affinity of enzymes for the interior of the caged-coacervates allowed us to assemble biomimetic microreactors with enhanced colloidal stability.
A CT 2–2 MASH ΔΣ ADC With Multi-Rate LMS-Based Background Calibration and Input-Insensitive Quantization-Error Extraction (2021)

This article presents a continuous-time (CT) multistage noise-shaping (MASH) delta–sigma ( <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\Delta \Sigma$ </tex-math></inline-formula> ) analog-to-digital converter (ADC) with enhanced tolerance to temperature and operating-frequency variations through on-chip multi-rate (MR) background calibration based on the least-mean-square (LMS) algorithm. The proposed digital calibration, which combines MR operation, post-conditioners, and pseudorandom-noise injection at the quantizer input, efficiently and accurately matches digital transfer functions to the corresponding analog ones for cancellation of quantization error. The first modulator in the proposed MASH ADC considers sufficient quantizer delay and reduces input-signal leakage into the second modulator to enable successful quantization-error transmission while minimizing distortion in the second stage, which cannot be tolerated in the case of calibrated digital noise-cancellation filter. A CT 2–2 MASH <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\Delta \Sigma $ </tex-math></inline-formula> ADC prototype fabricated in 40-nm CMOS achieves the dynamic range (DR) of 79 dB and the signal-to-noise and distortion ratio (SNDR) of 78.5 dB over an 8-MHz bandwidth with 7.3-mW analog power and 16-mW digital power, reaching Schreier figure of merit (FoMs) of 168.9 dB, and demonstrates conversion-accuracy robustness within 1-dB SNDR fluctuation for temperature variations from −40° to 125° and within 2-dB SNDR degradation for frequency variations of 20% range.
Case Series of Mayer–Rokitansky–Küster–Hauser Syndrome: Analysis of 17 Cases (2023)

Background: The Mayer–Rokitansky–Küster–Hauser (MRKH) syndrome is a rare disorder characterized by congenital vaginal defects and uterine traces. Because of its rarity, standardized management for MRKH syndrome is unavailable. This study reviewed the management of the patients with MRKH syndrome in our institution. Methods: Using medical records, we retrospectively reviewed the surgical techniques, outcomes, postoperative management methods, and outpatient follow-up of 17 patients with MRKH syndrome in Keio University Hospital. Results: Of the 14 patients who requested vaginoplasty, 12 underwent surgery with Davydov’s modified procedure after the Frank method, and it took 17 months to 34 months (median two years) for the vaginal cavity to enlarge by 5–6 cm. The Frank method is a non-surgical dilation with instrumental stretching of the vaginal vestibular mucosa. Davydov’s procedure is a surgical vaginoplasty in which the vesicoureteral space is coated by the peritoneum. Although one patient lost 3800 mL of bleeding from the plexus vein and four needed to remove the prosthesis under anesthesia about one month after surgery, all patients achieved anatomic success with a vaginal cavity length of 6 cm or more and could have sexual intercourse with their sexual partners. However, two patients interrupted their preoperative hospital visits, and three were lost to follow-up postoperatively. Two of the three patients who did not accept vaginoplasty presented myoma at uterine trace and underwent myomectomy. Another one was scheduled for surgery through psychological support. Conclusions: Davydov’s modified procedure is effective, and dilating the vaginal cavity adequately using the Frank method before surgery is needed to ensure sufficient vaginal length with less perineum. During the operation, attention is required to care for the plexus vein. Comprehensive psychological support, providing appropriate information to the patient for mental maturity, and planning surgery according to their life stages are essential for successful treatment.
Influence of the binder system on current and future demands for base materials (2006)

Purpose To give an overview of the problems that can occur with base laminate materials when converting to lead‐free soldering and to give guidance on possible solutions. Design/methodology/approach The paper contains a number of correlations between different physical measurements and their impact on real‐life processing conditions. The problem areas are highlighted and the corrective actions that need to be taken with base materials are described. Findings Results suggest that conventional FR4 resins might still be suitable for standard lead‐free applications that require only a few reflow cycles. However, with the growing complexity of board designs and the increasing number of solder cycles, better thermally resistant products are necessary. Other key resin parameters such as adhesion or toughness are also essential to enhance reliability. Originality/value The value of the paper lies in its provision of guidance on critical base material properties. It describes the change in physical properties that laminates will experience when moving to the higher temperatures needed for facilitate lead‐free assembly. Selection criteria for base materials are given that will help to minimise the impact of these higher temperatures.
Development of a multiplex-PCR for rapid detection of the enteric pathogens Lawsonia intracellularis, Brachyspira hyodysenteriae, and Brachyspira pilosicoli in porcine faeces (2006)

The availability of a new diagnostic M-PCR will allow rapid detection and control of three key porcine enteric pathogens.
The Effect of the Melanocortin Agonist, MT-II, on the Defended Level of Body Adiposity (2005)

A wide range of experimental evidence implicates a critical role for melanocortin signaling in the control of food intake and body adiposity. Melanocortin receptor agonists such as MT-II potently reduce food intake and body weight, making such agonists potential therapeutics for obesity. The critical concept addressed by the present experiments is whether the homeostatic effects of melanocortin agonists directly regulate food intake or whether the effects on food intake are secondary, with the primary effects being the regulation of body weight and adiposity. To investigate this, we compared the effect of various doses of MT-II given via osmotic minipump for 28 d to alter food intake, body weight, and body fat in dietary-induced obese rats. In addition, before the implantation of the minipump, dietary-induced obese rats were weight reduced by differing amounts using varying levels of food restriction. The results show that in food-restricted rats, MT-II-treated rats consume significantly more calories than those receiving MT-II after ad libitum access to food. More importantly, regardless of the widely differing levels of body fat among the different dietary treatments employed, body fat at the end of the study was determined exclusively by the dose of MT-II, with MT-II-treated rats having less body fat than vehicle-treated rats. These experiments support the hypothesis that melanocortin signaling primarily regulates total body adiposity and that food intake is adjusted as necessary to achieve a specific level of body adiposity.
Studies on on‐line bioreactor identification. II. Numerical and experimental results (1984)

The on-line bioreactor identification methodology of the preceding article (Part I) was tested with a series of numerical simulations and laboratory experiments. Results of these studies presented herein confirm the superior characteristics of the proposed estimator and its applicability to modelling studies, or on-line bioreactor control. The sensitivity of the estimation scheme with respect to the respiratory quotient measurement is discussed, and suggestions to bypass these problems are offered.
A Nanoscale Composite Material for Enhanced Damage Tolerance in MEMS Applications (2004)

A two-dimensional laminar composite material has been shown [1] to exhibit enhanced damage tolerance due to zones of residual compressive stress. The damage tolerance appears as a threshold stress below which the structure does not fail catastrophically. We utilize this concept at the microscale, towards obtaining fracture resistant MEMS structures. Cantilever beams of this laminar composite material, manufactured by MEMS fabrication methods are deflected to fracture, and the measured fracture strength compared to single crystal silicon beams (SCS) of identical geometry. All structures are made on the same die, so uniform processing damage is likely for all of them. A wide range of fracture strength is seen in both the composite and SCS beams. However, the lowest value of fracture stress for all the composite beams is found to be above the predicted threshold strength, while some of the SCS beams fail at lower stresses. We conclude that this composite offers a useful design alternative as a MEMS material.
Synchronization methods for communication with chaos over band‐limited channels (1999)

Methods of chaos synchronization applied to communication with chaotic signals over band-limited channels are studied numerically and experimentally. The first group of methods employs a filter in the receiver which is designed to compensate channel distortions of the transmitted signal. The second approach does not use the compensation but relies on the design of chaotic oscillators which shapes the spectrum of chaotic waveforms sent through the channel. Copyright © 1999 John Wiley & Sons, Ltd.
InGaN-based nanocoumn emitters suitable for display applications (2014)

In this paper, the emission characteristics based on photonic crystal effect of nanocolumn LEDs are discussed. The device exhibited electroluminescence (EL) and photoluminescence (PL) spectra with the narrow linewidth as well as with the sharp radiation beam profile, when the photonic band edge was controlled to be coincident with bandgap of the InGaN/GaN MQW emission region.
Moderate traumatic brain injury triggers long-term risks for the development of peripheral pain sensitivity and depressive-like behavior in mice (2022)

As traumatic brain injury (TBI) is one of the major causes of permanent disability, there is increasing interest in the long-term outcome of TBI. While motor deficits, cognitive impairment and longer-term risks of neurodegenerative disease are well-established consequences in animal models of TBI, pain is discussed less often despite its high prevalence. The current study addresses the need to characterize the extent of chronic pain and long-term behavioral impairments induced by moderate lateral fluid percussion injury (latFPI) in mice up to 12 months post-TBI and evaluates the validity of the model. Adult male BALB/c mice were subjected to latFPI, and the results were compared with outcomes in sham-operated mice. Mouse behavior was assessed at 1 and 7 days and 1, 3, 6, 9, and 12 months post-injury using sensory-motor (neurological severity score, NSS), cold (acetone) and mechanical sensitivity (von Frey), depressive-like behavior (tail suspension), locomotor (open field), motor coordination (rotarod) and cognitive (Morris water maze, y-maze, passive avoidance) tests. Animals with TBI demonstrated significantly higher NSS than the sham-operated group for up to 9 months after the injury. Cold sensitization was significantly increased in the contralateral hind paw in the TBI group compared to that of the sham group at 3, 6, and 9 months after TBI. In the von Frey test, the withdrawal threshold of the contralateral and ipsilateral hind paws was reduced at 6 months after TBI and lasted for up to 12 months post-injury. latFPI induced progressive depressive-like behavior starting at 6 months post-injury. No significant deficits were observed in memory, motor coordination or locomotion over the 12-month assessment period. The present study demonstrates that moderate TBI in mice elicits long-lasting impairment of sensory-motor function, results in progressive depression and potentiates peripheral pain. Hence, the latFPI model provides a relevant preclinical setting for the study of the link between brain injury and chronic sequelae such as depression and peripheral pain.
Using a double-doping strategy to prepare a bilayer device architecture for high-efficiency red PhOLEDs (2010)

A simple, bilayered, red phosphorescent organic light-emitting device featuring a doubly-doped emitting layer comprising of the novel hole-transporting host DTAF, the electron-transporting host 27SFBI, and the emitter Os(bpftz)2(PPhMe2)2 covering the interfacial region provides an unusually high current of ca. 1560 mA cm−2 at 8.5 V, a maximum brightness of 32 700 cd m−2, external quantum efficiencies as high as 12.3% (10.9% at 1000 cd m−2), and a power efficiency of 13.5 lm W−1. This concise device architecture is very cost-effective and competitive for practical applications.
Process optimization and proximity effect correction for gray scale e-beam lithography (2006)

Three-dimensional microstructures find applications in diffractive optical elements, photonic elements, etc., and can be efficiently fabricated by e-beam lithography. Good process control and efficient proximity effect correction are important for achieving the desired structures. With polymethylmethacrylate as the resist, a process optimization of different develop conditions is carried out to identify a process that is most conductive to gray scale features. A novel proximity effect correction scheme called effective dose-depth (EDD) method is proposed. Using the EDD method for grating design and the optimized process, blazed gratings have been fabricated with excellent uniformity and low surface roughness.