gebhart/patrepeval huggingface dataset:
Human mobile-device interaction on HEVC and H.264 subjective evaluation for video use in mobile environment (2013)

High Efficiency Video Coding (HEVC) is the next coding standard that is being finalized by ITU's Joint Collaborative Team on Video Coding (JCT-VC). This paper compares the H.264/AVC, current coding standard, and HEVC (aka H.265) in mobile compute environments. In this study, the focus, within the mobile compute environment, are smart phones. The major smart phone elements are smaller screen size, which is typically 3.5 inches diagonal to 5.0 inches diagonal for high end smart phones and typical cellular network bandwidth, which is typically 3G or faster. There is compelling subjective test feedback that indicates human device interaction focused on user's experience is very similar between HEVC and H.264 encoding standards for mobile environment screen size and higher cellphone bandwidth (such as 400kbps constant bit rate). This suggests the benefits of HEVC over H.264 in mobile environment are not as clear.
Molecular Characterization of Trop-2, a Cell Surface Molecule Highly Expressed by Human Carcinomas — Cloning of the Gene Encoding Trop-2 (1993)

Molecules preferentially or exclusively expressed by human cancer cells are of high interest, since they are likely to play a relevant role in the physiology of tumor cells and they may become useful targets for anti-cancer immunotherapy. gp50/Trop-2 is a monomelic cell surface glycoprotein expressed at high levels by trophoblast cells and by the majority of human carcinomas. On the other hand it is scarcely represented in most normal human epithelial tissues and absent in non-epithelial tissues, thus, becoming a useful marker of human epithelial malignancies. Since no information was available on the primary sequence of Trop-2, we undertook the cloning of the corresponding gene. We adopted a cDNA expression cloning procedure based on the CDM8 episomal vector, which was modified by us to improve its efficiency. With the modified technique, we have obtained transfection of 100% of the COS cells used, efficient selection of positive cells by cell sorting in flow and an overall sensitivity of screening of cDNA libraries of 1 positive clone dispersed in 105 irrelevant ones. We constructed a cDNA library in the CDM8 vector using mRNA from the OVCA-432 cell line, which expresses gp50/Trop-2 at high levels. From this library we isolated a clone encoding gp50/Trop-2. This clone contains a 2. 4 kb cDNA, which transfects gp50/Trop-2 and hybridizes with a single 2. 5 kb mRNA species from positive sources, including genomic transfectants expressing gp50/Trop-2. Southern blot analysis shows that Trop-2 is likely a single copy gene in human cells. The DNA sequence of the coding strand of the Trop-2 gene does not show significant homology to any other sequence available from data banks. However, quite surprisingly, the supposedly non-coding strand contains a gene highly homologous to GA733–1, a member of the Trop-1 family, tumor markers usually co-expressed with gp50/Trop-2. Even more surprisingly, also the GA733–1-like gene transfects for Trop-2. These findings have been confirmed by in vitro transcription and translation of the GA733–1 strand of the Trop-2 gene. Since preliminary findings indicate processing of the Trop-2 message after transfection in COS cells, we cloned and sequenced the genomic Trop-2 gene. Trop-2 is an intronless gene, which also possesses the property of transfecting for Trop-2 in both orientations. We speculate that the two complementary messages of the Trop-2 gene may play a relevant role in the regulation of the expression of Trop-2, each m. RNA being anti-sense for the other one.
An Efficient, Modular Synthetic Route to Oligomers Based on Zirconocene Coupling: Properties for Phenylene–Thiophene‐1‐Oxide and Phenylene–Thiophene‐1,1‐Dioxide Chains (2000)

Narrow band gaps and high electron affinities are associated with the new oligomers containing thiophene-1-oxide and thiophene-dioxide that have been prepared by zirconocene coupling methods. A series of oligomers with 3–11 rings (X=2 H, S, and S(=O)2; see picture) allow the electronic properties of conjugated chains to be investigated. Of particular note is that the less electron-withdrawing sulfoxide group results in the narrowest band gap.
Numerical simulations of stable, high-electron-density atmospheric pressure argon plasma under pin-to-plane electrode geometry: effects of applied voltage polarity (2020)

Abstract When applying high-voltage direct current to a pin-to-plane electrode geometry with a distance of 2 mm under atmospheric pressure in argon gas, electrical breakdown forms primary then secondary streamers. The polarity of the applied voltage affects this streamer-propagating phenomenon. Properties such as propagation speed, streamer head size, and plasma generation are parameterized at nanosecond scales by computational simulations of a self-consistent, multi-species, multi-temperature plasma fluid modeling approach. For positive polarity on the pin electrode, streamer-head propagation speeds up and streamer head size increases with increasing applied voltages. However, local electron density at the head decreases. For negative polarity, corona-like discharges form around the pin electrode under low applied voltages, and diffusive steamers form under high applied voltages. Secondary streamers re-propagate from the pin after primary streamer propagation, forming a plasma with a high electron density of 10 21 m −3 for the positive polarity. We show that low-voltage operations with positive polarity are useful for stable high-electron-density discharges under atmospheric pressure argon.
Laser Processing of 2-D and 3-D Structures for Tunable Embedded Capacitors (2011)

Material formulation, structuring, and modification are key to increasing the unit volume complexity and density of next generation electronic packaging products. Laser processing is finding an increasing number of applications in the fabrication of these advanced microelectronic devices. This is due, in part, to the ability to achieve highly localized treatment of materials with a spatial resolution of tens of microns. In addition, the process is data-driven, that is, patterns can be generated without the need for masking materials. In the present investigation, a variety of structures have been generated in polymer nanocomposites, nanoparticle films, and sol-gel thin films using a computer-controlled laser system. Specifically, micromachining technology has been used to produce both variable-thickness and discrete capacitors from a single sheet (layer) of capacitor material, such that both types of structures can be integrated into the same layer. In addition, the laser micromachining technology has been extended to design and develop new vertical multilayer embedded capacitors for high speed applications. High speed packages require thick dielectrics. Calculations show that multilayer vertical capacitors can be better than thick capacitors formed from a single layer. In general, multilayer embedded capacitors are fabricated by repeated lamination of resin-coated copper, or pre-preg with a capacitor core. This is a time consuming, lengthy process. As an alternative, we have deposited a single, thick capacitance layer, and subsequent laser micromachining has been used to form multiple parallel channels of a controlled depth. Metal deposition in the channels results in a multilayer embedded capacitor structure. Lasers micromaching can also provide various complex patterns such as 3-D spiral channels within a dielectric or magnetically active nanocomposite, subsequently filled with conducting materials to form inductors. This technique can be used to prepare inductors and capacitors in the same layer of nanocomposite material. Hence, the technique can be used to generate multi-functional structures for tunable device applications.
Fused Silica Final Optics for Inertial Fusion Energy: Radiation Studies and System-Level Analysis (2003)

AbstractThe survivability of the final optic, which must sit in the line of sight of high-energy neutrons and gamma rays, is a key issue for any laser-driven inertial fusion energy (IFE) concept. Previous work has concentrated on the use of reflective optics. Here, we introduce and analyze the use of a transmissive final optic for the IFE application. Our experimental work has been conducted at a range of doses and dose rates, including those comparable to the conditions at the IFE final optic. The experimental work, in conjunction with detailed analysis, suggests that a thin, fused silica Fresnel lens may be an attractive option when used at a wavelength of 351 nm. Our measurements and molecular dynamics simulations provide convincing evidence that the radiation damage, which leads to optical absorption, not only saturates but that a "radiation annealing" effect is observed. A system-level description is provided, including Fresnel lens and phase plate designs.
Targeting Cullin-RING E3 Ubiquitin Ligase 4 by Small Molecule Modulators (2021)

Cullin-RING E3 ubiquitin ligase 4 (CRL4) plays an essential role in cell cycle progression. Recent efforts using high throughput screening and follow up hit-to-lead studies have led to identification of small molecules <b>33-11</b> and <b>KH-4-43</b> that inhibit E3 CRL4's core ligase complex and exhibit anticancer potential. This review provides: 1) an updated perspective of E3 CRL4, including structural organization, major substrate targets and role in cancer; 2) a discussion of the challenges and strategies for finding the CRL inhibitor; and 3) a summary of the properties of the identified CRL4 inhibitors as well as a perspective on their potential utility to probe CRL4 biology and act as therapeutic agents.
Spectroscopic and Density Functional Theory Characterization of Common Lithium Salt Solvates in Carbonate Electrolytes for Lithium Batteries (2017)

The structure and composition of lithium ion solvation spheres of electrolyte solutions composed of common lithium salts (LiTFSI, LiPF6, LiBF4, and LiClO4) dissolved in aprotic polar linear and cyclic carbonate solvents (propylene carbonate (PC) or dimethyl carbonate (DMC)) have been investigated via a combination of FTIR, 13C NMR spectroscopy, and density functional theory (DFT). Results from the two different spectroscopic methods are in strong agreement with each other and with predictions from quantum chemistry calculations. The coordination of the carbonyl oxygen of the solvents to the lithium cation is observed by IR spectroscopy. The ratio of coordinated to uncoordinated PC and DMC has been used to determine solvent coordination numbers which range from 2 to 5 depending on salt, solvent, and concentration. The relative stability of the lithium–anion solvates were examined using DFT employing the cluster-continuum approach including changes to the intensity and frequency of the IR bands along with the populations of the cis–cis and cis–trans conformers of DMC in the lithium ion solvation shell. Solvent coordination is dependent upon the nature of the salt. Weakly associating salts, LiTFSI, LiPF6, and LiClO4, dissociate to a similar degree with LiPF6 being the most dissociated, while LiBF4 had significantly less dissociation in both solvents. This investigation provides significant insight into the solution structure of commonly used LIB electrolytes over a wide range of salt concentrations.
Pair Breaking Caused by Magnetic Impurities in the High-T$_\text{C}$ Superconductor Bi$_{2.1}$Sr$_{1.9}$Ca(Cu$_{1-x}$Fe$_{x}$)$_{2}$O$_{y}$ (2013)

Conventional superconductivity is robust against the addition of impurities unless the impurities are magnetic in which case superconductivity is quickly suppressed. Here we present a study of the cuprate superconductor Bi$_2$Sr$_2$Ca$_1$Cu$_2$O$_{8+δ}$ that is intentionally doped with the magnetic impurity, Fe. Through the use of our Tomographic Density of States (TDoS) technique, we find that while the superconducting gap magnitude is essentially unaffected by the inclusion of iron, the onset of superconductivity, T$_{C}$, and the pair-breaking rate are strongly dependent and correlated. These findings suggest that, in the cuprates, the pair-breaking rate is critical to the determination of T$_{C}$ and that magnetic impurities do not disrupt the strength of pairing but rather the lifetime of the pairs.
Development of a novel Silicone Rubber/Cement Plugging Agent for Cost Effective Thru' Tubing Well Abandonment (1998)

Abstract Large scale well abandonment campaigns will soon become a major cost issue for most Operators. Traditional well abandonment comprises the removal of the production tubing followed by well plugging by mechanical plugs (as primary seal), backed up by (potentially non sealing) cement plugs. The classical abandonment operation is very costly, especially in an offshore environment, since it requires the utilization of a workover or drilling rig. Significant savings could be achieved if wells could be abandoned by a Coiled Tubing operation, during which the production tubing could be left in- situ. After long negotiations, a major Dutch Oil and Gas Operator (NAM, Nederlandse Aardolie Maatschappij), convinced the legislative body of the Dutch Mining Department (SodM) that non workover rig assisted abandonment operations could be equally reliable as conventional abandonment methods provided certain operational precautions were taken. This entailed the rigorous cleaning of the production tubing and production liner by solvents and hot surfactant flushes and the utilization of (rotating) jet nozzles on CTU prior to setting of the sealing plugs. Furthermore, in critical (gas prone) wells special attention had to be devoted to the plugging material itself, since it now had to fulfill the duty of the mechanical seal, as well. Inherently, it had to display much-improved sealing characteristics (gas tightness, resilience, bonding) compared to conventional cement formulations. Novel Silicone Rubber/Portland Cement plugging materials have been developed for this application at Shell International Exploration and Production, Research and Technical Services (SIEP-RTS). This paper describes the laboratory development and screening (Sealing Ability, Mechanical Characteristics, Setting Kinetics, and Adhesion) of various candidate sealants and the optimization of these characteristics for a large scale well abandonment campaign. Trial well abandonment's using the new sealing agent(s) in NAM's Schoonebeek and Ijsselmonde/Ridderkerk Fields are discussed. P. 483
Le président de Thou justifié (2003)

info:eu-repo/semantics/published
Oxygen-binding to simple cobaltporphyrins combined with polyvinylmidazole (2002)

Reversible oxygen-binding was observed at low temperature for the poly(vinylimidazole-co-octyl methacrylate) complexes of the simple or planar cobaltporphyrins (CoP) such as cobalt-tetraphenylporphyrin and cobalt-octaethylporphyrin. The oxygen-binding affinity and rate constants were compared with those for the cobalt-picketfence porphyrin, a typical oxygen-carrier. The low oxygen-binding affinity for the CoP complexes was attributed to the enormously large oxygen-releasing rate constant.
Limitations of Membrane Structure and Dialyzer Design on Large Solute Removal in Dialysis (2000)

Review Articles| August 18 2000 Limitations of Membrane Structure and Dialyzer Design on Large Solute Removal in Dialysis Subject Area: Nephrology Norma J. Ofsthun Norma J. Ofsthun Fresenius Medical Care, Lexington, Mass., USA Search for other works by this author on: This Site PubMed Google Scholar Blood Purif (2000) 18 (4): 264–266. https://doi.org/10.1159/000014447 Article history Published Online: August 18 2000 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Norma J. Ofsthun; Limitations of Membrane Structure and Dialyzer Design on Large Solute Removal in Dialysis. Blood Purif 1 July 2000; 18 (4): 264–266. https://doi.org/10.1159/000014447 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBlood Purification Search Advanced Search This content is only available via PDF. © 2000 S. Karger AG, Basel2000Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Article PDF first page preview Close Modal You do not currently have access to this content.
Method for line-ground fault detection in variable frequency drives (2011)

An Industrial-Power-Converter-System (IPCS) is a system made up of several power converters, such as Adjustable Speed Drives (ASDs), filters, and reactive power-compensation components. An IPCS requires the ability to accurately detect and isolate electric faults to avoid further compromising the integrity of the system. A rather common type of electric fault is the line-to-ground fault. It can occur either from a phase line to ground or from a winding to ground. Due to the complexity and asymmetry of IPCSs, reliably detecting cable line-to-ground faults is a formidable task. In this paper, challenges and solutions to such challenges are discussed. In [1], advantages of using current signature over voltage signature are discussed. In this paper, a reliable line-to-ground fault detection method based on identifying current signature uniquely linked to the occurrence of the fault is presented. The selected signature greatly reduces nuisance tripping. Furthermore, a simple but powerful method to set a threshold for the selected signature is introduced.
Management of carotid artery transection resulting from a stab wound to the ear. (1985)

Emergency treatment of penetrating injury to the internal carotid artery at the skull base and within the temporal bone is difficult due to problems of exposure and control of this vessel. A successful method of management of a patient whose carotid artery was completely transected by a stab wound to the ear is presented. This involved gaining proximal vascular control in the neck and distal control intracranially. Indications for extracranial-intracranial vascular bypass procedures are discussed.
Statistical Analysis of Relative Labeled Mass Spectrometry Data from Complex Samples Using ANOVA (2008)

Statistical tools enable unified analysis of data from multiple global proteomic experiments, producing unbiased estimates of normalization terms despite the missing data problem inherent in these studies. The modeling approach, implementation, and useful visualization tools are demonstrated via a case study of complex biological samples assessed using the iTRAQ relative labeling protocol.
Data from Kub5-Hera<i><sup>RPRD1B</sup></i> Deficiency Promotes “BRCAness” and Vulnerability to PARP Inhibition in BRCA-proficient Breast Cancers (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;Identification of novel strategies to expand the use of PARP inhibitors beyond BRCA deficiency is of great interest in personalized medicine. Here, we investigated the unannotated role of Kub5-Hera&lt;sup&gt;RPRD1B&lt;/sup&gt; (K-H) in homologous recombination (HR) repair and its potential clinical significance in targeted cancer therapy.&lt;/p&gt;Experimental Design:&lt;p&gt;Functional characterization of K-H alterations on HR repair of double-strand breaks (DSB) were assessed by targeted gene silencing, plasmid reporter assays, immunofluorescence, and Western blots. Cell survival with PARP inhibitors was evaluated through colony-forming assays and statistically analyzed for correlation with K-H expression in various &lt;i&gt;BRCA1/2&lt;/i&gt; nonmutated breast cancers. Gene expression microarray/qPCR analyses, chromatin immunoprecipitation, and rescue experiments were used to investigate molecular mechanisms of action.&lt;/p&gt;Results:&lt;p&gt;K-H expression loss correlates with rucaparib LD&lt;sub&gt;50&lt;/sub&gt; values in a panel of &lt;i&gt;BRCA1/2&lt;/i&gt; nonmutated breast cancers. Mechanistically, K-H depletion promotes &lt;i&gt;BRCAness&lt;/i&gt;, where extensive upregulation of PARP1 activity was required for the survival of breast cancer cells. PARP inhibition in these cells led to synthetic lethality that was rescued by wild-type K-H reexpression, but not by a mutant K-H (p.R106A) that weakly binds RNAPII. K-H mediates HR by facilitating recruitment of RNAPII to the promoter region of a critical DNA damage response and repair effector, cyclin-dependent kinase 1 (&lt;i&gt;CDK1&lt;/i&gt;).&lt;/p&gt;Conclusions:&lt;p&gt;Cancer cells with low K-H expression may have exploitable &lt;i&gt;BRCAness&lt;/i&gt; properties that greatly expand the use of PARP inhibitors beyond BRCA mutations. Our results suggest that aberrant K-H alterations may have vital translational implications in cellular responses/survival to DNA damage, carcinogenesis, and personalized medicine.&lt;/p&gt;&lt;/div&gt;
Moth-eye structures for reduction of Fresnel losses at THz components (2006)

The applicability of moth-eye structures to THz components is investigated. With the help of RCWA and effective medium theory, optimal structural parameters for one-dimensional and two-dimensional periodical surface-relief gratings are deduced. The required structural parameters are in such order of magnitude that they can be manufactured by ultra-precision machining directly into the surface of the substrate material. Benefiting is that plastic materials, which are preferred materials in THz spectral region, can be accurately manufactured by ultra-precision machining. The application of the moth-eye structures follows directly the primary shaping of the components by conventional manufacturing methods like turning and milling so that no additional materials are necessary. A comparison between several structures fabricated on planar plastic probes is given.
ChemInform Abstract: Novel and Potent Aldose Reductase Inhibitors: 4‐Benzyl‐ and 4‐( Benzothiazol‐2‐ylmethyl)‐3,4‐dihydro‐3‐oxo‐2H‐1,4‐benzothiazine‐2‐ acetic Acid Derivatives. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.