gebhart/patrepeval huggingface dataset:
Project AutoVision: Localization and 3D Scene Perception for an Autonomous Vehicle with a Multi-Camera System (2018)

Project AutoVision aims to develop localization and 3D scene perception capabilities for a self-driving vehicle. Such capabilities will enable autonomous navigation in urban and rural environments, in day and night, and with cameras as the only exteroceptive sensors. The sensor suite employs many cameras for both 360-degree coverage and accurate multi-view stereo; the use of low-cost cameras keeps the cost of this sensor suite to a minimum. In addition, the project seeks to extend the operating envelope to include GNSS-less conditions which are typical for environments with tall buildings, foliage, and tunnels. Emphasis is placed on leveraging multi-view geometry and deep learning to enable the vehicle to localize and perceive in 3D space. This paper presents an overview of the project, and describes the sensor suite and current progress in the areas of calibration, localization, and perception.
MicroRNA signature in massive macronodular adrenocortical disease and implications for adrenocortical tumourigenesis (2009)

MicroRNAs appear to have distinct regulatory effects in MMAD, including an association with clinical presentation and severity of the disease, expressed by the degree of hypercortisolism. This is the first investigation of microRNAs in MMAD, a disease with complex pathogenesis; the data indicate that specific microRNAs such as miR-200b may play a significant role in MMAD formation and/or progression.
Genotoxicity of fluoroquinolines and methyiquinolines (1991)

Quinoline in the presence of microsomal activation exhibits mutagenic activity in Salmonella typhimurium TA100 and induces unscheduled DNA synthesis (UDS) in rat hepatocytes. Structure-activity studies were performed to determine those positions on quinoline critically associated with its genotoxicity. In assays performed to determine the ability of 2-, 4-, 6- and 8-methylquinoline to induce UDS, only 4- and 8-methylquinoline produced a positive response. This represents an improved correlation for these methylquinolines with tumorigenic activity as compared to that previously observed with mutagenic activity in S. typhimurium TA100. The complete isomeric series of fluoroquinolines were evaluated as mutagens in S. typhimurium TA100 and for their potential to induce UDS in rat hepatocytes. The only isomers that did not exhibit significant mutagenic activity were 2- and 3-fluoroquinoline. Among these isomeric fluoroquinolines 5-, 6-, 7- and 8-fluoroquinoline are capable of inducing UDS. No significant effect on UDS was observed for 2-, 3- or 4-fluoroquinoline. These data indicate that positions 1-3 in quinoline are critical sites associated with its genotoxicity.
Clustering of mouse and human leukocyte subsets (2011)

Hierarchical clustering with complete linkage was performed on the indicated cell populations isolated from: mouse, human, and mouse and human. PCA was performed on the indicated cell populations isolated from: mouse and human. Mono, monocytes; neu, neutrophils.<b>Copyright information:</b>Taken from "Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling"http://genomebiology.com/2008/9/1/R17Genome Biology 2008;9(1):R17-R17.Published online 24 Jan 2008PMCID:PMC2395256.
Dynamics of Active Separation Control at High Reynolds Numbers (2000)

A series of active flow control experiments were recently conducted at high Reynolds numbers on a generic separated configuration. The model simulates the upper surface of a 20 percent thick Glauert-Goldschmied type airfoil at zero angle of attack. The flow is fully turbulent since the tunnel sidewall boundary layer flows over the model. The main motivation for the experiments is to generate a comprehensive data base for validation of unsteady numerical simulation as a first step in the development of a CFD design tool, without which it would not be possible to effectively utilize the great potential of unsteady flow control. This paper focuses on the dynamics of several key features of the baseline as well as the controlled flow. It was found that the thickness of the upstream boundary layer has a negligible effect on the flow dynamics. It is speculated that separation is caused mainly by the highly convex surface while viscous effects are less important. The two-dimensional separated flow contains unsteady waves centered on a reduced frequency of 0.8, while in the three dimensional separated flow, frequencies around a reduced frequency of 0.3 and 1 are active. Several scenarios of resonant wave interaction take place at the separated shear-layer and in the pressure recovery region. The unstable reduced frequency bands for periodic excitation are centered on 1.5 and 5, but these reduced frequencies are based on the length of the baseline bubble that shortens due to the excitation. The conventional swept wing-scaling works well for the coherent wave features. Reproduction of these dynamic effects by a numerical simulation would provide benchmark validation.
Peptide inhibition experiments. (2015)

&lt;p&gt;Four serial 2-fold dilutions of IgG purified from rabbits immunized with ITM1_4 (ITM1_4-1; -2; -3 and -4) and UG_A (UG_A-1; -2; -3 and -4) were used in a modified pseudovirus neutralization assay using SF162. Two linear peptides 797 and 7012.1, recognizing the V3-crown motif of clade B (GPGR) and clade A (GPGQ) respectively and 1 cyclic peptide 7019 recognizing GPGR (clade B) were used at a final concentration of 16 µg/ml. Each graph represents a single rabbit.&lt;/p&gt;
ChemInform Abstract: 9‐FLUORENYLMETHYL ESTERS (1983)

Abstract Durch Umsetzung der aktiven Aminosäureester (I) mit 9‐Fluorenylmethanol (II) werden die geschützten Aminosäuren (III) erhalten.
Infectious Complications of Central Venous Catheters Increase the Risk of Catheter-Related Thrombosis in Hematology Patients: A Prospective Study (2005)

The risk of clinically manifest thrombosis is increased after an episode of CVC-related infection in patients undergoing intensive chemotherapy. Surveillance culturing of CVC lock fluid may be clinically useful in estimating the risk for thrombosis and the instigation of focused early intervention.
HDAC11 Inhibits T-Cell Response to Alloantigens and Reduces Gvhd In Mice. (2010)

Abstract Abstract 1466 Background: Histone acetyltransferases and histone deacetylases (HDAC) regulate gene expression through acetylation-deacetylation of histones. HDACs are the target of a family of compounds known as HDAC inhibitors, which have been shown to suppress pro-inflammatory cytokines and reduce acute graft-versus-host disease (GVHD) while preserving the graft-versus-leukemia (GVL) effect after allogeneic bone marrow transplantation (BMT) in mice. However, the role of individual HDAC members in the development of GVHD is not clear. Recently, HDAC11, the newest member of the HDAC family has emerged as an important transcriptional regulator of inflammatory responses in antigen-presenting cells (APCs)1. Here, we evaluated the role of HDAC11 on APCs and T cells in the allogeneic BMT setting in mice with genetic disruption of HDAC11. Method: Proliferation of wild-type (WT) and HDAC11 knock-out (KO) T cells in response to allogeneic antigens was compared by [H3] thymidine incorporation assay. Using the same method, we also tested the antigen presentation ability of WT and HDAC11 KO APCs. For in vivo studies, we used a clinical relevant mouse model of BMT: C57BL/6 (B6) ® BALB/c. To evaluate the role of HDAC11 in the function of T cells and APCs, WT and KO mice on B6 background were used as donors and recipients, respectively. Recipient survival was monitored daily and GVHD symptom was evaluated at least twice a week. HDAC11 KO mice were supplied by Merck and Co., Inc. Results: In vitro, HDAC11 KO T cells proliferated stronger than WT T cells under the stimulation of allogeneic APCs. Recipients of HDAC11 KO T cells lost significantly more body weight (p &lt; 0.05), and died significantly sooner than those of WT T cells (p &lt; 0.01). The pathologic score of KO recipients was higher than that of WT recipients in each of GVHD target organs including lung, liver, small intestine and colon. Mechanistically, we found that there were significantly more total and IFNγ-producing donor T cells in the recipients of KO cells than those of WT cells (p &lt; 0.05). Collectively, HDAC11 KO T cells have higher activity in response to alloantigens in vitro and induced more severe GVHD in vivo compared to WT T cells. In contrast, KO and WT APCs had a similar ability to stimulate allogeneic T cells in vitro, and no significant difference in GVHD development was observed in WT or KO recipients after allogeneic BMT. Conclusion: HDAC11 negatively regulates T-cell function, but has no significant effect on APC function. This finding provides a rationale to promote T-cell immunity or tolerance by inhibiting or enhancing HDAC11, respectively. 1 Villagra et al. Nature Immunology, 10:92-100, 2009. Disclosures: No relevant conflicts of interest to declare.
Recombinant Tumor-Associated MUC1 Glycoprotein Impairs the Differentiation and Function of Dendritic Cells (2005)

Tumors exploit several strategies to evade immune recognition, including the production of a large number of immunosuppressive factors, which leads to reduced numbers and impaired functions of dendritic cells (DCs) in the vicinity of tumors. We have investigated whether a mucin released by tumor cells could be involved in causing these immunomodulating effects on DCs. We used a recombinant purified form of the MUC1 glycoprotein, an epithelial associated mucin that is overexpressed, aberrantly glycosylated, and shed during cancer transformation. The O-glycosylation profile of the recombinant MUC1 glycoprotein (ST-MUC1) resembled that expressed by epithelial tumors in vivo, consisting of large numbers of sialylated core 1 (sialyl-T, ST) oligosaccharides. When cultured in the presence of ST-MUC1, human monocyte-derived DCs displayed a modified phenotype with decreased expression of costimulatory molecules (CD86, CD40), Ag-presenting molecules (DR and CD1d), and differentiation markers (CD83). In contrast, markers associated with an immature phenotype, CD1a and CD206 (mannose receptor), were increased. This effect was already evident at day 4 of DC culture and was dose dependent. The modified phenotype of DCs corresponded to an altered balance in IL-12/IL-10 cytokine production, with DC expressing an IL-10(high)IL-12(low) phenotype after exposure to ST-MUC1. These DCs were defective in their ability to induce immune responses in both allogeneic and autologous settings, as detected in proliferation and ELISPOT assays. The altered DC differentiation and Ag presentation function induced by the soluble sialylated tumor-associated mucin may represent a mechanism by which epithelial tumors can escape immunosurveillance.
Innovative Approaches in Environmental Medicine: Redox/Detoxification Biomarkers in Environmental Intolerances (2013)

Editorial Special Issue "Innovative Approaches in Environmental Medicine: Redox/Detoxification Biomarkers in Environmental Intolerances"
Adaptive Future Frame Prediction with Ensemble Network (2020)

Future frame prediction in videos is a challenging problem because videos include complicated movements and large appearance changes. Learning-based future frame prediction approaches have been proposed in kinds of literature. A common limitation of the existing learning-based approaches is a mismatch of training data and test data. In the future frame prediction task, we can obtain the ground truth data by just waiting for a few frames. It means we can update the prediction model online in the test phase. Then, we propose an adaptive update framework for the future frame prediction task. The proposed adaptive updating framework consists of a pre-trained prediction network, a continuous-updating prediction network, and a weight estimation network. We also show that our pre-trained prediction model achieves comparable performance to the existing state-of-the-art approaches. We demonstrate that our approach outperforms existing methods especially for dynamically changing scenes.
A Novel Web-Oriented Writing Environment Using Objects' Facts Acquired from the Web (2007)

This paper presents a novel web-oriented writing environment that helps users describe their opinions on topics/events through weblogs, by showing facts related to the objects. Our writing environment automatically recognizes information needs for facts on aspects (e.g., "opening hours") of the objects (e.g., "J's cafe") by applying lexico- syntactic patterns to the snapshots of users' writings. It then attempts to extract facts that satisfy the information needs from the Web, and shows the extracted facts (e.g., "opening hours"-"10am-8:30pm") to the users. The users can thus refer to necessary facts without searching the web by themselves. We realized this environment for Japanese on a browser with AJAX, and evaluated how much useful information could be provided by our environment.
A systems chemical biology study of malate synthase and isocitrate lyase inhibition in Mycobacterium tuberculosis during active and NRP growth (2020)

The ability of Mycobacterium tuberculosis (Mtb) to survive in low oxygen environments enables the bacterium to persist in a latent state within host tissues. In vitro studies of Mtb growth have identified changes in isocitrate lyase (ICL) and malate synthase (MS) that enable bacterial persistent under low oxygen and other environmentally limiting conditions. Systems chemical biology (SCB) enables us to evaluate the effects of small molecule inhibitors not only on the reaction catalyzed by malate synthase and isocitrate lyase, but the effect on the complete tricarboxylic acid cycle (TCA) by taking into account complex network relationships within that system.
A Compact Model for Ferroelectric Capacitors Based on Multidomain Phase-Field Framework (2023)

A generalized and fast multidomain phase-field-based compact model for the metal-ferroelectric-metal (MFM) capacitor is presented. Time-dependent Landau–Ginzburg (TDGL) and Poisson’s equations are solved self-consistently to model the polarization dynamics. Additionally, physics-based empirical relationships for voltage-dependent kinetic and gradient energy coefficients are formulated. It is also demonstrated how gradient energy coefficient needs to be modified to accurately capture the physics of the device when a coarse simulation grid is used for fast computation. The developed model is 30000 times faster than our prior multidomain phase-field model with no degradation in accuracy. Moreover, a further computational speedup has been achieved by decreasing the number of Poisson solver nodes with a slight compromise of accuracy. The model shows a good agreement with the experimental results of both transient characteristics and minor hysteresis loops. The proposed model has the potential to facilitate fast and accurate simulations of large-scale circuits containing ferroelectric capacitors.
Energy-Efficient Application Mapping in FPGA through Computation in Embedded Memory Blocks (2012)

FPGAs have emerged as the preferred prototyping and accelerator platform for diverse application domains such as digital signal processing (DSP), security and multimedia, which often impose real-time performance requirements. Most applications in these domains require efficient implementation of complex data paths or functions, e.g. transcendental functions which are spatially mapped in the configurable logic or embedded DSP blocks of a FPGA device. Requirement of elaborate computational resources to realize these operations impose a major barrier to energy efficiency. In this paper, we propose to use embedded memory blocks in FPGA for computing to significantly improve energy efficiency of the applications which are dominated by complex data paths and/or functions. Complex operations are decomposed into large multi-input/output lookup tables (LUTs); mapped to embedded memory blocks and evaluated through memory access over single or multiple cycles. Different parts of an application are selectively mapped into memory or logic/DSP blocks in a heterogeneous mapping framework to maximize energy efficiency. We explore optimal energy configuration of embedded memory for mapping applications of varying input size and develop a complete mapping flow including decomposition, fusion and packing. Effectiveness of the proposed flow is evaluated using a commercial state-of-the-art FPGA system (Altera Stratix IV device). Finally the proposed framework is used to drastically trade-off energy vs accuracy at run-time for common signal processing applications.
Alternative Polymer Systems for Proton Exchange Membranes (PEMs) (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Technique-Sensitivity of Contemporary Adhesives (2005)

Besides micro-mechanical interlocking through hybrid-layer formation, self-etch adhesives may benefit from additional chemical interaction between the functional monomer and residual hydroxyapatite. One-step adhesives are commonly associated with lower bonding effectiveness, which must be attributed in part to the dissolution of hydrophilic and hydrophobic monomers in a relatively highly concentrated solvent. In this 'difficult' mixture, also water is essential as ionization medium to enable self-etching activity. Due to the high hydrophilicity, one-step self-etch adhesives have been reported to behave as semi-permeable membranes, allowing fluids to pass through and seriously jeopardizing bond durability. Recent research has also revealed that HEMA-free one-step adhesives are prone to phase-separation, which may also account for their lower bonding effectiveness. Employing an appropriate air-drying technique may, however, improve the bonding effectiveness of such phase-separating adhesives by getting rid of substantially more interfacial water than HEMA-containing adhesives, of which water might be more difficult to remove from.
S3126 Characterization of Test Performance and Participant Attributes Among Individuals Completing FIT in a Prospective, Multicenter Clinical Study (2020)

INTRODUCTION: Currently, one out of three age-eligible, average-risk adults in the US remains unscreened for colorectal cancer (CRC). FIT is a commonly used non-invasive option for CRC screening. In this study, we sought to evaluate the characteristics of individuals who completed FIT and to analyze the clinical performance of FIT in this population. METHODS: AI-EMERGE is a multi-center, prospective study in which blood and optional stool samples were collected. Univariate analyses of demographics, lifestyle choices, and comorbidities compared participants who did or did not complete FIT, and those who had positive vs negative FIT results. Multivariate stepwise logistic regression examined contributing factors for FIT completion and for FIT result. FIT performance was characterized across the disease spectrum (e.g., CRC, advanced adenoma (AA), non-advanced adenoma (NAA) and colonoscopy-confirmed negative) and across other parameters, including lesion size, location, and histology. RESULTS: Of 3472 study participants, only 52% completed FIT. Univariate analyses showed that participants who completed FIT were younger than those who did not (P < 0.01), and more self-identified as never smokers, never drinkers, and non-illicit drug users (all P < 0.05). Participants were more likely to complete FIT if they self-identified as never or former smokers (OR = 1.3 [1.1–1.6]), never drinkers (OR = 1.4 [1.2–1.6]), or age ≤50 years old (OR = 1.3 [1.0–1.7]). A FIT-positive test was associated with older age, larger lesion size, and more distal lesion location (all P < 0.01). FIT sensitivity was 73% (46/63) for CRC, 16% (27/166) for AAs, and 4% (14/369) for NAAs, with a specificity of 97% (962/989). Subgroup analyses demonstrated greater sensitivity for AAs with high-grade dysplasia (vs all other AA subtypes, including ≥1cm SSPs) and for larger lesions (CRC and AA). Increased sensitivity was also observed for distal vs proximal lesions for AAs and NAAs. CONCLUSION: In this study, only 52% of participants who provided blood also completed FIT, and these individuals were generally at lower risk of CRC based on lifestyle choices and demographics. These observations highlight that adherence remains a challenge with current screening options, and the sensitivity of FIT, whether for CRC or adenomas, remains suboptimal. More patient-friendly screening options, such as blood tests with better clinical performance than FIT, are needed to improve adherence and help achieve the national goal of at least 80% screened in every community.
Serotype Differences and Lack of Biofilm Formation Characterize Yersinia pseudotuberculosis Infection of the Xenopsylla cheopis Flea Vector of Yersinia pestis (2006)

Yersinia pestis, the agent of plague, is usually transmitted by fleas. To produce a transmissible infection, Y. pestis colonizes the flea midgut and forms a biofilm in the proventricular valve, which blocks normal blood feeding. The enteropathogen Yersinia pseudotuberculosis, from which Y. pestis recently evolved, is not transmitted by fleas. However, both Y. pestis and Y. pseudotuberculosis form biofilms that adhere to the external mouthparts and block feeding of Caenorhabditis elegans nematodes, which has been proposed as a model of Y. pestis-flea interactions. We compared the ability of Y. pestis and Y. pseudotuberculosis to infect the rat flea Xenopsylla cheopis and to produce biofilms in the flea and in vitro. Five of 18 Y. pseudotuberculosis strains, encompassing seven serotypes, including all three serotype O3 strains tested, were unable to stably colonize the flea midgut. The other strains persisted in the flea midgut for 4 weeks but did not increase in numbers, and none of the 18 strains colonized the proventriculus or produced a biofilm in the flea. Y. pseudotuberculosis strains also varied greatly in their ability to produce biofilms in vitro, but there was no correlation between biofilm phenotype in vitro or on the surface of C. elegans and the ability to colonize or block fleas. Our results support a model in which a genetic change in the Y. pseudotuberculosis progenitor of Y. pestis extended its pre-existing ex vivo biofilm-forming ability to the flea gut environment, thus enabling proventricular blockage and efficient flea-borne transmission.
International network for capacity building for the control of emerging viral vector-borne zoonotic diseases: ARBO-ZOONET (2009)

Arboviruses are arthropod-borne viruses, which include West Nile fever virus (WNFV), a mosquito-borne virus, Rift Valley fever virus (RVFV), a mosquito-borne virus, and Crimean-Congo haemorrhagic fever virus (CCHFV), a tick-borne virus. These arthropod-borne viruses can cause disease in different domestic and wild animals and in humans, posing a threat to public health because of their epidemic and zoonotic potential. In recent decades, the geographical distribution of these diseases has expanded. Outbreaks of WNF have already occurred in Europe, especially in the Mediterranean basin. Moreover, CCHF is endemic in many European countries and serious outbreaks have occurred, particularly in the Balkans, Turkey and Southern Federal Districts of Russia. In 2000, RVF was reported for the first time outside the African continent, with cases being confirmed in Saudi Arabia and Yemen. This spread was probably caused by ruminant trade and highlights that there is a threat of expansion of the virus into other parts of Asia and Europe. In the light of global warming and globalisation of trade and travel, public interest in emerging zoonotic diseases has increased. This is especially evident regarding the geographical spread of vector-borne diseases. A multi-disciplinary approach is now imperative, and groups need to collaborate in an integrated manner that includes vector control, vaccination programmes, improved therapy strategies, diagnostic tools and surveillance, public awareness, capacity building and improvement of infrastructure in endemic regions.