gebhart/patrepeval huggingface dataset:
Natural Killer Cells for Therapy of Leukemia (2016)

Clinical application of natural killer (NK) cells against leukemia is an area of intense investigation. In human leukocyte antigen-mismatched allogeneic hematopoietic stem cell transplantations (HSCT), alloreactive NK cells exert powerful anti-leukemic activity in preventing relapse in the absence of graft-versus-host disease, particularly in acute myeloid leukemia patients. Adoptive transfer of donor NK cells post-HSCT or in non-transplant scenarios may be superior to the currently widely used unmanipulated donor lymphocyte infusion. This concept could be further improved through transfusion of activated NK cells. Significant progress has been made in good manufacturing practice (GMP)-compliant large-scale production of stimulated effectors. However, inherent limitations remain. These include differing yields and compositions of the end-product due to donor variability and inefficient means for cryopreservation. Moreover, the impact of the various novel activation strategies on NK cell biology and in vivo behavior are barely understood. In contrast, reproduction of the third-party NK-92 drug from a cryostored GMP-compliant master cell bank is straightforward and efficient. Safety for the application of this highly cytotoxic cell line was demonstrated in first clinical trials. This novel 'off-the-shelf' product could become a treatment option for a broad patient population. For specific tumor targeting chimeric-antigen-receptor-engineered NK-92 cells have been designed.
Transition metal methylene complexes. 13. Proton-induced ring opening of a dimetallacyclopropane-type .mu.-methylene-rhodium compound. A straightforward novel route to halo(methyl) complexes (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTransition metal methylene complexes. 13. Proton-induced ring opening of a dimetallacyclopropane-type .mu.-methylene-rhodium compound. A straightforward novel route to halo(methyl) complexesWolfgang A. Herrmann, Johann Plank, Manfred L. Ziegler, and Barbara BalbachCite this: J. Am. Chem. Soc. 1980, 102, 18, 5906–5908Publication Date (Print):August 1, 1980Publication History Published online1 May 2002Published inissue 1 August 1980https://pubs.acs.org/doi/10.1021/ja00538a034https://doi.org/10.1021/ja00538a034research-articleACS PublicationsRequest reuse permissionsArticle Views73Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
ChemInform Abstract: New Two‐Dimensional Niobium and Vanadium Carbides as Promising Materials for Li‐Ion Batteries. (2014)

Abstract New two‐dimensional niobium and vanadium carbide phases are prepared by treating Nb 2 AlC and V 2 AlC in aqueous HF at room temperature for 90 h.
Old Molecules for New Receptors: Trp(Nps) Dipeptide Derivatives as Vanilloid TRPV1 Channel Blockers (2006)

The transient receptor potential vanilloid member 1 (TRPV1), an integrator of multiple pain-producing stimuli, is regarded nowadays as an important biological target for the discovery of novel analgesics. Here, we describe the first experimental evidence for the behavior of an old family of analgesic dipeptides, namely Xaa-Trp(Nps) and Trp(Nps)-Xaa (Xaa=Lys, Arg) derivatives, as potent TRPV1 channel blockers. We also report the synthesis and biological investigation of a series of new conformationally restricted Trp(Nps)-dipeptide derivatives with improved TRPV1/NMDA selectivity. Compound 15 b, which incorporates an N-terminal 2S-azetidine-derived Arg residue, was the most selective compound in this series. Collectively, a new family of TRPV1 channel blockers emerged from our results, although further modifications are required to fine-tune the potency/selectivity/toxicity balance.
Experimental demonstration of superconducting bandpass delta-sigma modulator (2003)

Superconducting bandpass delta-sigma (/spl Delta//spl Sigma/) modulators are being developed for direct analog-to-digital conversion of radio frequency signals in the GHz range. Recently we demonstrated operation of a superconducting bandpass /spl Delta//spl Sigma/ modulator with the highest center frequency (2.23 GHz) and sampling rate (up to 45 GHz) reported to date. The test chip used in that experiment includes an integrated acquisition memory, which eliminates the need for very high speed interfacing. This paper describes key implementation details of this complex test chip, which contains 4065 Josephson junctions. The paper also explains how magnetic coupling from large power supply currents can be reduced through the use of optically-isolated current sources with independent grounds. The measured output spectra of the modulator at a 45 GHz sampling rate are presented.
Adaptive characterization and emulation of delay-based physical unclonable functions using statistical models (2015)

It is commonly known that physical unclonable functions (PUFs) are hard to predict and hard to emulate. However, in this paper, we propose to use statistical models to adaptively characterize the delay-based PUFs, and use this as a starting point to emulate a delay-based PUF. The essential idea is that for any challenge CA of a delay-based PUF A, there is a high probability of finding a paired challenge CB. When apply CB to another delay-based PUF B, it can produce the same output as applying CA on PUF A. Our simulation results indicate more than 99% correctness for the PUF response prediction using characterization and 96% correctness using emulation. Finally, we implement and test the feasibility of our approach on the Xilinx Spartan-6 Field Programmable Gate Array (FPGA).
Chemical ordering and large tunnel magnetoresistance in Co2FeAl/MgAl2O4/Co2FeAl(001) junctions (2016)

Epitaxial magnetic tunnel junctions (MTJs) with a Co2FeAl/CoFe (0.5 nm)/MgAl2O4/Co2FeAl(001) structure were fabricated by magnetron sputtering. High-temperature in situ annealing led to a high degree of B2-order in the Co2FeAl layers and cation order of the MgAl2O4 barrier. Large tunnel magnetoresistance (TMR) of up to 342% was obtained at room temperature (616% at 4 K), in contrast to the TMR ratio (%) suppressed by the band-folding effect in Fe/cation-ordered MgAl2O4/Fe MTJs. The present study reveals that the high degree of B2-order and the resulting high spin polarization in the Co2FeAl electrodes enable us to bypass the band-folding problem in spinel barriers.
A system for searching and browsing spoken communications (2004)

As the amount of spoken communications accessible by computers increases, searching and browsing is becoming crucial for utilizing such material for gathering information. It is desirable for multimedia content analysis systems to handle various formats of data and to serve varying user needs while presenting a simple and consistent user interface. In this paper, we present a research system for searching and browsing spoken communications. The system uses core technologies such as speaker segmentation, automatic speech recognition, transcription alignment, keyword extraction and speech indexing and retrieval to make spoken communications easy to navigate. The main focus is on telephone conversations and teleconferences with comparisons to broadcast news.
Deep Reflectance Volumes: Relightable Reconstructions from Multi-View\n Photometric Images (2020)

We present a deep learning approach to reconstruct scene appearance from\nunstructured images captured under collocated point lighting. At the heart of\nDeep Reflectance Volumes is a novel volumetric scene representation consisting\nof opacity, surface normal and reflectance voxel grids. We present a novel\nphysically-based differentiable volume ray marching framework to render these\nscene volumes under arbitrary viewpoint and lighting. This allows us to\noptimize the scene volumes to minimize the error between their rendered images\nand the captured images. Our method is able to reconstruct real scenes with\nchallenging non-Lambertian reflectance and complex geometry with occlusions and\nshadowing. Moreover, it accurately generalizes to novel viewpoints and\nlighting, including non-collocated lighting, rendering photorealistic images\nthat are significantly better than state-of-the-art mesh-based methods. We also\nshow that our learned reflectance volumes are editable, allowing for modifying\nthe materials of the captured scenes.\n
Friction and Surface Deformation in Electrodeposited Gold Alloy Thin Films. (2006)

Abstract not provided.
8-Hydroxy-2′-deoxyguanosine in cervical cells: correlation with grade of dysplasia and human papillomavirus infection (2000)

In this study, the 8-hydroxy-2′-deoxyguanosine (8-OHdG) level was assessed in human cervical cells by an immunoperoxidase method and was related to the presence of human papillomavirus (HPV) infection and precancerous lesions. After optimizing the immunohistochemical method of detecting oxidative DNA damage in whole cells, we have used this technique to estimate the oxidative damage in cervical cells collected during a routine PAP test. The analysis of variance (ANOVA) of the data from human samples showed significant differences in the 8-OHdG content among normal, low-grade and high-grade squamous intraepithelial lesion (SIL, HGSIL and LGSIL, respectively; P < 0.001). In the comparison of the three groups, statistically significant differences were detected between normal SIL and HGSIL ( P < 0.001) and between LGSIL and HGSIL ( P = 0.003), whereas no statistically significant difference was found between normal SIL and LGSIL ( P = 0.1). Grouping observations by HPV status, no significant difference was detected in 8-OHdG levels between HPV + and HPV – subjects ( P = 0.8). The polytomous and proportional odds models, extensions of the logistic regression analysis, showed that the effect of 8-OHdG levels in rising the risk of dysplasia was roughly constant through SIL grades. In conclusion, the immunoperoxidase method, applied to single human cervical cells, provides clear evidence that significant differences exist in 8-OHdG content between normal and dysplastic cells and that oxidative DNA damage might play an important role in cervical carcinogenesis.
Experiments in sensing and communication for robot convoy navigation (2002)

This paper deals with coordinating behaviour in a multi-autonomous robot system. When two or more autonomous robots must interact in order to accomplish some common goal, communication between the robots is essential. Different inter-robot communications strategies give rise to different overall system performance and reliability. After a brief consideration of some theoretical approaches to multiple robot collections, we present concrete implementations of different strategies for convoy-like behaviour. The convoy system is based around two RWI B12 mobile robots and uses only passive visual sensing for inter-robot communication. The issues related to different communication strategies are considered.
Supplementary Materials and Methods from Regulation of Lung Cancer Metastasis by Klf4-Numb–like Signaling (2023)

&lt;p&gt;PDF File - 4789K, REGULATION OF LUNG CANCER METASTASIS BY Klf4-Numb-like SIGNALING.&lt;/p&gt;
Structure–property correlations in a combinatorial library of degradable biomaterials (1998)

A combinatorial library of degradable polyarylates was prepared. These polymers are A-B–type copolymers consisting of an alternating sequence of a diphenol and a diacid. The library was prepared by copolymerizing, in all possible combinations, 14 different tyrosine-derived diphenols and eight different aliphatic diacids, resulting in 8 × 14 = 112 distinct polymers. This approach (a) increases the number of available polymeric candidate materials for medical applications, and (b) facilitates the identification of correlations between polymer structure and glass transition temperature, air–water contact angle, mechanical properties, and fibroblast proliferation. The pendent chain and backbone structures were systematically varied by (a) simple homologative variations in the number of methylene groups, (b) substitution of oxygen for methylene groups, and (c) introduction of branched and aromatic structures. The polymers contained within the library exhibited incremental variations in Tg (from 2°C to 91°C) and air–water contact angle (from 64° to 101°). Fibroblast proliferation (in vitro, serum-containing media) ranged from approximating that measured on tissue culture polystyrene to complete absence of proliferation. Generally, decreased proliferation correlated linearly with increased surface hydrophobicity, except in those polymers derived from oxygen-containing diacids in their backbone which were uniformly good growth substrates even if their surfaces were very hydrophobic. In a selected subgroup of polymers, tensile strength of thin solvent cast films ranged from about 6 to 45 MPa, while Young's modulus (stiffness) ranged from about 0.3 to 1.7 GPa. Combinatorial biomaterial libraries such as these tyrosine-derived polyarylates permit the systematic study of material-dependent biological responses and provide the medical device designer with the option to choose a suitable material from a library of related polymers that encompasses a broad range of properties. © 1998 John Wiley & Sons, Inc. J Biomed Mater Res, 42, 66–75, 1998.
Glycoprotein J of infectious laryngotracheitis virus is required for efficient egress of infectious virions from cells (2011)

Glycoprotein J (gJ) of infectious laryngotracheitis virus (ILTV) represents a major viral antigen and is dispensable for replication in cell culture and chickens. We generated gJ deletion mutants derived from the United States Department of Agriculture standard challenge strain (USDA-ch), a GFP-expressing mutant GΔgJ, a gJ deletion mutant void of any foreign DNA insertion (BΔgJ) and a gJ rescue mutant gJR with US5 restored. GΔgJ, BΔgJ and gJR were characterized in cell culture and embryonated eggs. Entry kinetic assays showed that the gJ deletion mutants did not differ in their entry kinetics from gJR. Replication kinetics strongly indicated that gJ plays an important role during egress of the virus. Differences in the abilities of the mutants to replicate in chorioallantoic membranes of chicken embryos and to release infectious virus into the allantoic fluid supported a function of gJ during the egress of ILTV from infected cells.
Primary amyloidosis A. Immunohistochemical and biochemical characterization. (1987)

Primary "idiopathic" amyloidosis is usually related to immunoglobulin light chain (AL) associated with immunocytic dyscrasias, while secondary "reactive" amyloidosis (AA) is related to serum amyloid A protein (SAA) and typically occurs with chronic inflammation, malignancy, or familial Mediterranean fever. In the present study, amyloid fibril protein extracted from frozen and paraffin-embedded tissue from a patient (CAR) with primary systemic amyloidosis proved to be AA protein by immunohistochemical, immunochemical, and amino terminal sequence. Extracts from both frozen and formalin-fixed paraffin-embedded kidney and spleen yielded similar monomers and dimers of the AA protein. The additional high-molecular-weight bands and a distinct 12,000-dalton fragment in the amyloid protein extracted from the formalin-fixed paraffin-embedded lung suggest that different processing of proteins, ie, by polymerization and/or degradation, may occur in different organs.
ChemInform Abstract: Radical Cations of Bis(diphenylphosphino) Derivatives (Ph2P‐R‐PPh2): The Formation of Localized, Cyclic, and Dimeric Configurations. An ESR and Quantum Chemical Study. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Acousto-microfluidic Control of Liquid Crystals (2023)

The optical properties of liquid crystals serve as the basis for display, diagnostic, and sensing technologies. Such properties are generally controlled by relying on electric fields. In this work, we investigate the effects of microfluidic flows and acoustic fields on the molecular orientation and the corresponding optical response of nematic liquid crystals. Several previously unknown structures are identified, which are rationalized in terms of a state diagram as a function of the strengths of the flow and the acoustic field. The new structures are interpreted by relying on calculations with a free energy functional expressed in terms of the tensorial order parameter, using continuum theory simulations in the Landau-de Gennes framework. Taken together, the findings presented here offer promise for the development of new systems based on combinations of sound, flow, and confinement.
A Prototype PZT Matrix Transducer With Low-Power Integrated Receive ASIC for 3-D Transesophageal Echocardiography (2015)

This paper presents the design, fabrication, and experimental evaluation of a prototype lead zirconium titanate (PZT) matrix transducer with an integrated receive ASIC, as a proof of concept for a miniature three-dimensional (3-D) transesophageal echocardiography (TEE) probe. It consists of an array of 9 ×12 piezoelectric elements mounted on the ASIC via an integration scheme that involves direct electrical connections between a bond-pad array on the ASIC and the transducer elements. The ASIC addresses the critical challenge of reducing cable count, and includes front-end amplifiers with adjustable gains and micro-beamformer circuits that locally process and combine echo signals received by the elements of each 3 ×3 subarray. Thus, an order-of-magnitude reduction in the number of receive channels is achieved. Dedicated circuit techniques are employed to meet the strict space and power constraints of TEE probes. The ASIC has been fabricated in a standard 0.18-μm CMOS process and consumes only 0.44 mW/channel. The prototype has been acoustically characterized in a water tank. The ASIC allows the array to be presteered across ±37° while achieving an overall dynamic range of 77 dB. Both the measured characteristics of the individual transducer elements and the performance of the ASIC are in good agreement with expectations, demonstrating the effectiveness of the proposed techniques.
Clinical studies in CKD 1-5 (2012)

Introduction and Aims: Impaired kidney function is one of important factors participating in the pathogenesis of alterated endocrine function in elderly subjects. Adiponectin is an adipokine with antiatherosclerotic, cardioprotective and antidiabetic properties. The aim of present study was to estimate plasma adiponectin concentration and their relationship with estimated glomerular filtration rate (eGFR) in representative samples of the elderly population in Poland. Methods: The study was carried out as a part of the nationwide PolSenior project in the population of randomly selected 4979 (2412 females and 2567 males) aged 65-101 years. In 3692 subjects (1762 females and 1930 males) plasma adiponectin concentration was assessed by an ELISA method and eGFR was estimated using the CKD-EPI formula. Results: Females aged 65-90 years were characterized by significantly higher than males plasma adiponectin concentration (13.3 6.8 vs 11.0 5.9 g/ml; p < 0.001). Analysis of variance, between groups stratified according to eGFR with respect of plasma adiponectin concentration showed significant ( p < 0.001) differences [in subject with eGFR 90-120 ml/min (n = 304) 11.2 6.3 g/ml; eGFR 60-90 ml/min (n = 2273) 11.9 6.3 g/ml; eGFR 45-60 ml/min (n = 723) 12.4 6.6 g/ml; eGFR < 45 ml/min (n = 392) 13.1 6.6 g/ml]. A significant negative correlations were found between plasma adiponectin concentration and eGFR(r=-0.082, p < 0.001). Multiple regression analysis with gender, age and eGFR as independent factors showed that all of the above mentioned factors have significant influence on plasma adiponectin concentration in the elderly Polish population ( = 0.192; p < 0.001, = 0.334; p < 0.001 and = -0.08; p < 0.001, respectively). Conclusion: An increase of plasma adiponectin concentrations in the elderly subjects seems to be secondary to the age-related decline of the kidney function.
Abstract 2331: HDAC6, new role as master regulator of PD-L1 and immune-related pathways (2016)

Abstract Histone deacetylases (HDACs), originally described as histone modifiers, have more recently been demonstrated to modify a variety of other proteins involved in diverse cellular processes unrelated to the chromatin environment, including the modulation of proteins related to cell cycle/apoptosis and immune regulation. In contrast to the well-documented effects of HDAC inhibitors (HDACi) in the control of cell cycle and apoptosis, their role in immunobiology is still not completely understood, and the reported immunological outcomes when using HDACi are heterogeneous. Our group recently reported that the pharmacological or genetic abrogation of a single HDAC, HDAC6, modulates the expression of immuno-regulatory proteins, including PD-L1, PD-L2, MHC class I, B7-H4 and TRAIL-R1. We primarily focused in PD-L1, which is an important negative regulator of T-cell function and often over-expressed in cancer cells. In a mechanistic point of view, we have found that the pharmacological inhibition and genetic abrogation of HDAC6 inactivates the STAT3 pathway, impairs the nuclear translocation and the recruitment of STAT3 to the PD-L1 promoter and subsequently down-regulates the expression of PD-L1. Moreover, the in vivo abrogation of HDAC6 reduces tumor growth in melanoma models, effect that is enhanced in the presence of the immune check-point blocking antibodies anti-PD-1 and anti-CTLA4. These results provide a key pre-clinical rationale and justification to further study isotype selective HDAC6 inhibitors as potential immunomodulatory agents in cancer. Citation Format: Tessa Knox, Maritza Lienlaf, Patricio Perez, Mibel Pabon, Calvin Lee, Fengdong Cheng, Eva Sahakian, John Powers, Susan Deng, Smalley Keiran, Alan Kozikowski, Javier Pinilla, Amod Sarnaik, Ed Seto, Jeffrey Weber, Eduardo Sotomayor, Alejandro Villagra. HDAC6, new role as master regulator of PD-L1 and immune-related pathways. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 2331.