gebhart/patrepeval huggingface dataset:
High-precision integration approach based on alignment maintaining flip-chip bonding using cone shaped bump and truncated pyramid pad (2014)

In this paper, a high-precision heterogeneous integration approach based on a high alignment accuracy flip-chip bonding using nanoparticle deposition (NpD) cone shaped (CS) bumps and anisotropic wet-etching truncated pyramid (TIP) bonding pads is introduced to precisely control the post-bond position of the bonding chip. Experimental results show that the bonding chip could be confined within sub-micro ranges in all the X-, y- and z-axis. Moreover, reliable bonds with ohmic contacts were realized at 150°C, capable for edge emitting laser (EEL) chip staking applications.
Quaternary AlInGaN Multiple Quantum Wells for Ultraviolet Light Emitting Diodes (2001)

We report on a novel pulsed atomic layer epitaxy (PALE) growth technique for quaternary AlInGaN films for ultraviolet optoelectronics applications. Using the PALE approach, quaternary AlInGaN/AlInGaN multiple quantum wells (MQWs) were successfully grown over sapphire substrates. These were characterized using X-ray diffraction, atomic force microscopy, and photoluminescence to establish structural and optical quality. Incorporating the PALE grown quaternary MQWs as the active layer we also demonstrated ultraviolet electroluminescence at 343 nm with an output power up to 0.12 mW at room temperature.
Une nouvelle espèce pour le genre Pseudombrophila (Pezizales), P. subalpina (Jamoni) comb. nov. (2018)

The review of the type material of Trichophaea subalpina, combined with a molecular analysis, repositioned this species in the Pseudombrophila clade into the Pyronemataceae s. lato. The species is combined in the genus Pseudombrophila despite a taxonomy not totally resolved through the phylogenetic analysis
Exploiting suspected redundancy without proving it (2005)

We present several improvements to general-purpose sequential redundancy removal. (1) We propose using a robust variety of synergistic transformation and verification algorithms to process the individual proof obligations. This enables greater speed and scalability, and identifies a significantly greater degree of redundancy, than prior approaches. (2) We generalize upon traditional redundancy removal and utilize the speculatively-reduced model to enhance bounded search, without needing to complete any proofs.
Analysis of catechol as an environmental pollutant based on electropolymerised methyl orange modified carbon paste sensor (2023)

The present research work outlines a low-cost and green electrochemical approach for the assay of ecological toxin catechol (CT) based on electro-polymerised methyl orange (MO)-activated carbon paste electrode (CPE) as a responsive, simple and low-priced electrocatalyst. The CT electrochemical response was premeditated on the surface of poly methyl orange-activated carbon paste electrode (Poly(MO)ACPE) using different voltammetric methods such as cyclic voltammetry (CV) and differential pulse voltammetry (DPV) which recommends that the Poly(MO)ACPE shows good electrocatalytic nature for the electrochemical redox reaction of CT with high peak current response as associated to the bare carbon paste electrode (BCPE). The CT molecules expose electrochemical quasi-reversible reactions (oxidation and reduction nature) at Poly(MO)ACPE, which was done by a diffusion-controlled reaction kinetics. The practicability of this sensor was verified using the DPV method; here the CT peak current was improved with the varied concentration of CT in the range from 1.0 µM to 36.0 µM, and the corresponding limit of detection (LOD) and limit of quantification (LOQ) were 0.880 × 10−8 M and 2.935 × 10−8 M, respectively. The prepared sensor was efficiently tested with different interferents using the DPV method. Here, the sensor shows a lesser interference effect for the CT redox reaction nature. Finally, this sensor was applied for the analysis of CT in water and green tea samples, and the outcomes noticed a good CT recoveries.
A tele-gait monitoring system with an inertial measurement unit and smart shoes (2011)

In this paper, a tele-gait monitoring system which consists of an inertial measurement unit (IMU) and Smart Shoes is proposed for gait monitoring and rehabilitation. In our previous works, a mobile gait monitoring system (MGMS) was proposed, which utilized the ground reaction forces (GRFs) measured by Smart Shoes. Although the GRF patterns measured by the MGMS provide useful information for the diagnoses of a patient's walking motions, Smart Shoes do not measure the position of the feet, which is necessary for a complete walking motion diagnosis. In the proposed tele-gait monitoring system, an IMU is used in addition to Smart Shoes for a complete observation of walking motions. By analyzing the signals measured by the IMU and Smart Shoes, it is possible to thoroughly diagnose the patient's walking motion, including: the trajectory of the foot, the walking distance, and the length of each stride. Furthermore, the proposed gait monitoring system makes use of the Internet such that physical therapists can monitor their patients' status anywhere anytime.
Monolithic Silicon-On-Nothing Fiber-Based Pressure Sensors (2019)

Monolithic-silicon fiber-based pressure sensors offer high resolution over a broad frequency range with minimal footprint. We fabricate these devices using scalable single frontside mask silicon nanofabrication. Our sensors consist of a sealed 1 μm cavity under a 1 μm thick silicon diaphragm only 100 μm in diameter. For static pressures from 0.3 to 1.4 atm, our sensors showed a standard deviation of 2.6×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> atm from the reference. For dynamics pressures out to 50 kHz, our sensors show a pressure resolution of 1.1×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-6</sup> atm/√Hz.
OHRA: Towards an Open Hypermedia Reference Architecture and a Migration Path for Existing Systems (1997)

The open hypermedia research community recognised that to make progress on defining a protocol to enable third party applications to access open link services, it was necessary to first establish a reference architecture for open hypermedia systems upon which to base discussions. In this paper we argue that there is a need to extend yet further the scope of these requirements. We propose an overall architecture for the integration of existing open hypermedia systems in a distributed and collaborative model, and provide a clear evolution path towards achieving this goal.
Femtosecond synchronization of two passively mode-locked Ti:sapphire lasers (1996)

We describe a method of reducing the timing jitter between two passively mode-locked femtosecond titanium:sapphire laser systems, enabling femtosecond-resolved measurements with independently tunable pump and probe wavelengths. The scheme supplements a commercially available system (Coherent Synchrolock) which locks two Ti:sapphire lasers to a master clock. By selecting only those pulses which are temporally coincident within a user-specified range, a timing jitter reduction between the two lasers from ∼3 ps to &amp;lt;200 fs FWHM can be achieved, as measured by optical cross correlation. The timing jitter between the lasers is easily varied, allowing optimization of the tradeoff between temporal resolution and throughput depending on experimental needs.
Electron-density topology and interaction energy in hydrogen-bonded systems (2011)

C445 of natural bond orbitals (NBO). This method can only be applied to the wavefunction obtained by either HF or Kohn-Sham DFT methods.
Activation of Acid Sphingomyelinase and Its Inhibition by the Nitric Oxide/Cyclic Guanosine 3′,5′-Monophosphate Pathway: Key Events in Escherichia coli-Elicited Apoptosis of Dendritic Cells (2004)

Depletion of dendritic cells (DCs) via apoptosis contributes to sepsis-induced immune suppression. The mechanisms leading to DC apoptosis during sepsis are not known. In this study we report that immature DCs undergo apoptosis when treated with high numbers of Escherichia coli. This effect was mimicked by high concentrations of LPS. Apoptosis was accompanied by generation of ceramide through activation of acid sphingomyelinase (A-SMase), was prevented by inhibitors of this enzyme, and was restored by exogenous ceramide. Compared with immature DCs, mature DCs expressed significantly reduced levels of A-SMase, did not generate ceramide in response to E. coli or LPS, and were insensitive to E. coli- and LPS-triggered apoptosis. However, sensitivity to apoptosis was restored by addition of exogenous A-SMase or ceramide. Furthermore, inhibition of A-SMase activation and ceramide generation was found to be the mechanism through which the immune-modulating messenger NO protects immature DCs from the apoptogenic effects of E. coli and LPS. NO acted through formation of cGMP and stimulation of the cGMP-dependent protein kinase. The relevance of A-SMase and its inhibition by NO/cGMP were confirmed in a mouse model of LPS-induced sepsis. DC apoptosis was significantly higher in inducible NO synthase-deficient mice than in wild-type animals and was significantly reduced by treatment ex vivo with NO, cGMP, or the A-SMase inhibitor imipramine. Thus, A-SMase plays a central role in E. coli/LPS-induced DC apoptosis and its inhibition by NO, and it might be a target of new therapeutic approaches to sepsis.
Hip arthroplasty in patients with systemic lupus erythematosus. (1987)

Forty-three prosthetic hip replacements (twenty-nine conventional total hip replacements and fourteen bipolar endoprosthetic replacements) were implanted between January 1971 and June 1982 in thirty-one patients who had systemic lupus erythematosus. All but four patients had stage-III or IV osteonecrosis of the femoral head. The median age at operation was forty-three years, and the median length of follow-up was fifty-seven months. Ratings were good or excellent for all but three total hip arthroplasties at a mean of sixty-six months of follow-up. Complications included delayed wound-healing (in approximately 15 per cent) and superficial wound infection (in approximately 10 per cent). The occurrence of these complications could not be correlated with the use of corticosteroids at the time of the operation. Twenty-five per cent of the patients, who were a mean of forty-three years old at operation, died less than five years postoperatively from complications related to systemic lupus erythematosus. Conclusions regarding the systemic effects of hip arthroplasty in patients with systemic lupus erythematosus could not be drawn on the basis of this study. Total hip arthroplasty uniformly provided a good or excellent result in patients of all ages who had systemic lupus erythematosus at a mean length of follow-up of sixty-six months. An increased incidence of local wound complications, which were unrelated to the use of corticosteroids, should be expected in patients with systemic lupus erythematosus who undergo prosthetic arthroplasty of the hip.
GUMBOS matrices of variable hydrophobicity for matrix‐assisted laser desorption/ionization mass spectrometry (2014)

MALDI matrices of GUMBOS with tunable hydrophobicities are easily obtained simply by varying the counterion. We have found that hydrophobic matrix materials are very effective for MALDI determination of hydrophobic peptides and, similarly, the more hydrophilic peptides displayed greater intensity in the more hydrophilic matrix.
A three-dimensional model of the δ-opioid pharmacophore: Comparative molecular modeling of peptide and nonpeptide ligands (2000)

A comparative molecular modeling study of delta-opioid ligands was performed under the assumption that potent peptide and nonpeptide agonists may have common three-dimensional (3D) arrangement of pharmacophore groups upon binding to the delta-receptor. Low-energy conformations of the agonists 7-spiroindanyloxymorphone (SIOM) and 2-methyl-4a-alpha-(3-hydroxyphenyl)-1,2,3,4,4a,5,12, 12a-alpha-octahydro-quinolino[2,3,3-g]isoquinoline (TAN-67), and a partial agonist oxomorphindole (OMI) were determined by high-temperature molecular dynamics (MD). A good spatial overlap was found for the pharmacophore groups of SIOM, TAN-67, and OMI, including the basic nitrogen, phenol hydroxyl, and two aromatic ring. Based on this overlap we proposed a 3D pharmacophore model for nonpeptide delta-opioid agonists with a distance of 7.0 +/- 1.3 A between the two aromatic rings and of 8.2 +/- 1.0 A between the nitrogen and phenyl ring. The potent and highly delta-opioid receptor selective agonist [(2S,3R)-TMT(1)]DPDPE, which shares global backbone constraints of the 14-membered disulfide cycle and a strong preference for the trans rotamer of the TMT(1) side chain, was chosen as a peptide template of the delta-opioid pharmacophore. Extensive MD simulations at 300 K with the AMBER force field were performed for [(2S,3R)-TMT(1)]DPDPE and the less potent [(2S, 3S)-TMT(1)]DPDPE analogue. Multiple MD trajectories were collected for each peptide starting from the x-ray structures of DPDPE and [L-Ala(3)]DPDPE and from models proposed in the literature. Low-energy MD conformations were filtered by the nonpeptide pharmacophore query and then directly superimposed with SIOM, OMI, and TAN-67. Two conformers of [(2S,3R)-TMT(1)]DPDPE that showed the best overlap with the nonpeptide pharmacophore (rms deviation </= 1. 0 A for N,O atoms and centroids of two aromatic rings) were selected as possible delta-receptor binding conformations. These conformations have similar backbone structures, and trans rotamers of the TMT(1) side-chain group. They are reasonably close to the crystal structure of [L-Ala(3)]DPDPE, and differ significantly from the crystal structure of DPDPE. The conformer with a gauche(-) rotamer of Phe(4) is most consistent with structure-activity relationships of delta-opioid peptides. The proposed 3D models were used for rational design of new nonpeptide delta-receptor ligands.
Platform IO and system memory test using L3 cache based test (CBT) and parallel execution of CPGC Intel BIST engine (2015)

As the memory industry pushes to increase memory density, device variation is creating more defects. Furthermore, new form factors (phone, tablet, mobile and client PC) and low cost board and platform limits physical access to JTAG or TAP. Taking advantage of the x86 architecture's high functional bandwidth to memory, the quickest way to access and test memory is through CPU core, by storing and running parallel CPGC/BIST test content via CPU L3 cache, one CPGC BIST engine per memory channel. We propose a cache based testing framework that speeds up test time 60× to 170× compared to JTAG or TAP based testing using the same test content. We will present the cache based test (CBT) architecture and infrastructure (MRC/NEM setup, CPGC/IBIST), test content, results, and a side by side comparison of test time to JTAG or TAP. Finally we will discuss and compare this approach to generalized cache based tests.
Predicting and optimizing etch recipes for across the wafer uniformity (2019)

Uniformity of critical dimensions (CDs) across a wafer is an increasing challenge as both CDs and tolerances shrink. Plasma etch uniformity is achieved in part through reactor design and in part through the operating conditions or process recipe of the reactor. The identification of a recipe for a specific etch process is time consuming and expensive, requiring extensive experiments and metrology. Here we present two modules in SandBox StudioTM, SB-Bayesian and SBNeuralNet, to accelerate the prediction and optimization of etch recipes for across the wafer uniformity. A model of etch rates across the wafer is created that accounts for injector locations, gas flow rates and distribution and plasma powers. Synthetic experiments on etching line-space patterns on 300 mm wafers are performed and the CDs and their variations are computed at several hundred site locations. SB-Bayesian requires many fewer experiments to be calibrated and achieve an excellent qualitative match with the experimental data. SB-NeuralNet achieves comparable levels of accuracy to SBBayesian at predicting average CDs and uniformity, but it does not perform as well at predicting trends across the wafer. It is shown that neural nets require a prohibitive amount of experimental data to successfully predict wafer patterns. SBBayesian and SB-NeuralNet were used to create detailed process maps across the parameters space of interest to identify optimal recipes to achieve required CDs and tolerances. Both modules can predict optimal recipe conditions for achieving identified target CD and uniformity metrics. Using these tools, etch recipes for across the wafer uniformity are rapidly optimized at lower cost.
Design and Preliminary Field Validation of a Fully Passive Prosthetic Knee Mechanism for Users With Transfemoral Amputation in India (2018)

An estimated 230,000 above-knee amputees in India are currently in need of prosthetic devices, a majority of them facing severe socio-economic constraints. However, only a few passive prosthetic knee devices in the market have been designed for facilitation of normative gait kinematics and for meeting the specific daily life needs of above-knee amputees in the developing world. Based on the results of our past studies, this paper establishes a framework for designing a potentially low-cost, fully passive prosthetic knee device, which aims to facilitate able-bodied kinematics at a low metabolic cost. Based on a comprehensive set of functional requirements and biomechanical analysis from our past work, we present an early prototype mechanism for the prosthetic knee joint that is primarily focused on enabling able-bodied kinematics. The mechanism is implemented using two functional modules: an automatic early stance lock for stability and a differential friction damping system for late stance and swing control. For preliminary, qualitative validation of the knee mechanism, we carried out a field trial on four above-knee amputees in India, which showed satisfactory performance of the early stance lock. The prototype enabled smooth stance-to-swing transition by timely initiation of late stance flexion. Possible methods of incorporating an additional spring module for further refinement of the design are also discussed, which can enable flexion-extension during the early-stance phase of the gait cycle and potentially reduce the metabolic energy expenditure of the user further.
Oxidized analogs of Di(1H-indol-3-yl)methyl-4-substituted benzenes are NR4A1-dependent UPR inducers with potent and safe anti-cancer activity (2018)

Di(1<i>H</i>-indol-3-yl)(4-trifluoromethylphenyl)methane (DIM-Ph-4-CF<sub>3</sub>) is an analog of orphan nuclear receptor 4A1 (NR4A1) ligand cytosporone B. We have synthesized several oxidation products of DIM-Ph-4-CF<sub>3</sub>, focusing on analogs with electron-withdrawing or donating groups at their phenyl ring 4-positions, and examined their anti-cancer activity and mechanism-of-action. Mesylates (DIM-Ph-4-X<sup>+</sup> OMs<sup>-</sup>s) having CF<sub>3</sub>, CO<sub>2</sub>Me and Cl groups were more effective inhibitors of cancer cell viability than their precursors. <sup>19</sup>F NMR spectroscopy and differential scanning calorimetry strongly indicated interactions of DIM-Ph-4-CF<sub>3</sub><sup>+</sup> OMs<sup>-</sup> with the NR4A1 ligand binding domain, and compound-induced apoptosis of prostate cancer cells was dependent on NR4A1. DIM-Ph-4-CF3<sup>+</sup> OMs<sup>-</sup> showed robust inhibition of LNCaP prostate cancer xenografts with no apparent toxicity. <i>In vitro</i> and <i>in vivo</i>, DIM-Ph-4-CF3<sup>+</sup> OMs<sup>-</sup> activated proapoptotic unfolded protein response (UPR) signaling in prostate cancer cells. Independently of DIM-Ph-4-CF<sub>3</sub><sup>+</sup> OMs<sup>-</sup>, the bulk of NR4A1 localized to the cytoplasm in various cancer cell lines, suggesting a cytoplasmic mechanism-of-action of DIM-Ph-4-CF<sub>3</sub><sup>+</sup> OMs<sup>-</sup> in UPR induction and cell death. In summary, the data suggest that oxidized analogs of DIM-Ph-4-CF3 possess potent and safe anti-cancer activity which is mediated through UPR signaling downstream of NR4A1 binding.
Effects of striatal excitotoxicity on Huntingtin-like immunoreactivity (1995)

The relationship between the specific neuronal loss observed in Huntington's disease and the mutation in the IT15 gene responsible for this disease remains obscure. Using an antipeptide antibody against amino acids 3114-3141 of the human huntingtin protein, we demonstrate that striatal injection of quinolinic acid in mice induces increased immunoreactivity for huntingtin in some remaining neurons but not in glial cells. This increase is apparent in both neuronal cell bodies and in cell processes in the white matter six hours after excitotoxic challenge. This finding suggests that huntingtin may be involved in the response to excitotoxic stress in these neurons.
Integrated reservoir characterization of the Wattenberg Field, Colorado, USA (2018)

Increased hydrocarbon recovery is essential for continued economic development of unconventional reservoirs. Our project focuses on dynamic characterization of the Niobrara and Codell formations in the Wattenberg field through the development and analysis of a full integrated reservoir model. The ultimate goal is to optimize the exploration and exploitation of the reservoir and this paper discusses our progress. Our work on hydraulic fracture simulations that include input from both 1D and 3D geomechanical models presents insight into how to properly incorporate reservoir heterogeneity. The hydraulic fracture simulation results are history matched and then input into a flow simulator and ran for 2 years of production. The results are then integrated with both microseismic and time-lapse multi-component seismic. In addition, a seismic based facies inversion gives insight into future well planning. Presentation Date: Wednesday, October 17, 2018 Start Time: 1:50:00 PM Location: 209A (Anaheim Convention Center) Presentation Type: Oral
Elastic full-wavefield inversion for presalt carbonate reservoir characterization in offshore Brazil (2022)

Pre-salt carbonate reservoir characterization from seismic data is critical for hydrocarbon exploration to assist assessment processes of a prospect. It has been challenging for geoscientists to extract relevant information from seismic data to characterize reservoir presence (RP) and reservoir quality (RQ) of carbonate reservoir due to the stiff nature of carbonate rocks. In addition to the carbonate rock itself, complex salt geometry above carbonate reservoirs and the limited usable seismic information of narrow azimuth streamer survey made conventional workflows for pre-salt reservoir characterization incomplete and unstable. In this study, we utilize the full potential of FWI with higher level of physics to resolve the challenges for pre-salt carbonate. We demonstrate the elastic FWI workflow combined with other velocity model building tools can directly estimate elastic parameters of pre-salt carbonate reservoir from a streamer seismic dataset and these inverted elastic parameters (P-impedance and Vp/Vs) from elastic FWI can be used for a quantitative carbonate reservoir characterization.