gebhart/patrepeval huggingface dataset:
Molecular Determinants of Biased Agonism at the Dopamine D2Receptor (2015)

The development of biased (functionally selective) ligands provides a formidable challenge in medicinal chemistry. In an effort to learn to design functionally selective molecular tools for the highly therapeutically relevant dopamine D2 receptor, we synthesized a collection of agonists based on structurally distinct head groups derived from canonical or atypical dopaminergic pharmacophores. The test compounds feature a long lipophilic appendage that was shown to mediate biased signaling. By employing functional assays and molecular dynamics simulations, we could show that atypical dopamine surrogates of type 1 and 2 promote biased signaling, while ligands built from classical dopaminergic head groups (type 3 and 4) typically elicit more balanced signaling profiles. Besides this, we found a strong influence of the stereochemistry of type 4 aminotetraline-derived agonists on functional selectivity at D2 receptors. Whereas the (S)-enantiomer behaved as a full agonist, the biased ligand (R)-4 induced poor G protein coupling but substantial β-arrestin recruitment.
Flexible Creation and Adaptive Execution of Scientific Workflows in Cloud and Grid Environments by Using Web 2.0-Based Electronic Lab Notebook Metaphor (2010)

A metaphor of Electronic Lab Notebook (ELN) can be leveraged not only to make the process of creation and editing of scientific workflows easier, but to execute, monitor, and troubleshoot workflows. By using ELN as a metaphor for Scientific Workflow Management System (SWFMS), scientific users can have the familiar user interface it offers with the benefits of SWFMS, such as the ability to automate recording provenance of scientific experiments and to facilitate reproducing of scientific results. Furthermore, Web 2.0 can enhance ELN to make it easier to collaborate and share scientific content by using emerging Web standards. Cloud and Grid environments require that workflows be fault-tolerant and can adapt to changes. ELN, as an underlying storage model for SFWMS, allows necessary flexibility in adapting running workflows both automatically and by users editing ELN to change their workflows.
AT1 receptors in the subfornical organ modulate arterial pressure and the baroreflex in two-kidney, one-clip hypertensive rats (2019)

The subfornical organ (SFO), a forebrain circumventricular organ that lies outside the blood-brain barrier, has been implicated in arterial pressure and baroreflex responses to angiotensin II (ANG II). We tested whether pharmacological inhibition or selective silencing of SFO ANG II type 1 receptors (AT<sub>1</sub>R) of two-kidney, one-clip rats with elevated plasma ANG II decreases resting arterial pressure and renal sympathetic nerve activity (RSNA) and/or modulates arterial baroreflex responses of heart rate (HR) and RSNA. Male Sprague-Dawley rats underwent renal artery clipping [2-kidney, 1-clip (2K,1C)] or sham clipping (sham). After 6 wk, conscious rats instrumented with vascular catheters, renal nerve electrodes, and a cannula directed to the SFO were studied. In another set of experiments, rats were instrumented with hemodynamic and nerve radio transmitters and injected with scrambled RNA or silencing RNA targeted against AT<sub>1</sub>R. Mean arterial pressure (MAP) was significantly higher in 2K,1C rats. Acute SFO injection with the AT<sub>1</sub>R inhibitor losartan did not change MAP in sham or 2K,1C rats. Baroreflex curves of HR and RSNA were shifted rightward in 2K,1C rats. Losartan exerted no effect. SFO AT<sub>1</sub>R knockdown did not influence MAP in sham rats but decreased MAP in 2K,1C rats, despite no change in plasma ANG II or resting RSNA. AT<sub>1</sub>R knockdown prevented the reduction in maximum gain and slope of baroreflex responses of HR and RSNA; the reduced RSNA response to baroreceptor unloading was partially restored in 2K,1C rats. These findings show that AT<sub>1</sub>R activation within the SFO contributes to hypertension and baroreflex dysfunction in 2K,1C rats and highlight the temporal requirement for reversal of these effects.
S108. AUTOMATED DETECTION OF INCREASED METAPHOR PRODUCTION IN OPEN-ENDED SPEECH IN SCHIZOPHRENIA AND ITS RISK STATES (2020)

Abstract Background Clinicians have long observed peculiarities in the use of figurative language by individuals with schizophrenia, as part of larger expressive deficits. Natural language processing has been used to predict psychosis onset (Bedi et al., 2015; Corcoran et al., 2018), identifying classifiers such as semantic coherence. Here we examine use of metaphor across the psychosis spectrum. Methods Participant groups across the psychosis spectrum (healthy controls, clinical high risk for psychosis and individuals with schizophrenia) participated in open-ended interviews lasting approximately one hour and encouraged to express themselves narratively. Each interview was transcribed, then deidentified and run through the metaphor analysis algorithm. The results were then used to determine an overall metaphor frequency rate for each participant/transcript. Results The algorithm detected a significantly higher proportion of the words in transcripts of patients with schizophrenia as metaphorical (6.5%) than in healthy controls’ transcripts (5.7%) (p &amp;lt; 0.01, t57 = 2.68). Patients in the CHR group also produced more metaphorical words tagged by the algorithm (6.6%; p &amp;lt; 0.01, t95 = 3.69). Discussion These results demonstrate that metaphor usage, as measured using automated algorithms, is a robust and powerful indicator of symptoms, whether defined via current schizophrenia diagnosis or by clinical high-risk status. The ability to estimate metaphoric content in speech and written samples can be a significant contribution to the systemization of psychosis symptoms and and may be useful as a screen for the general population to identify individuals who may be at risk for psychosis.
Neural Network Based Available Bandwidth Estimation in the ETOMIC Infrastructure (2007)

Efficient and reliable available bandwidth measurement remains an important goal for many applications. In this paper we introduce an empirical bandwidth estimation tool based on neural networks. Training the neural network on simulation data, it provides reliable estimation of physical and available bandwidth for simulated single and multi-hop networks, in laboratory environment and among the real world conditions of the ETOMIC testbed.
Intra-abdominal hypertension causes reversible blood-brain barrier disruption (2011)

IAH of 20 mm Hg in mice for 4 hours caused increased BBB permeability. This endothelial barrier dysfunction is reversed by abdominal DC.
Droplet Digital PCR Quantification of Mantle Cell Lymphoma Follow‐up Samples From Four Prospective Trials of the European MCL Network (2020)

Minimal residual disease (MRD) has been increasingly investigated in mantle cell lymphoma (MCL), including for individual therapeutic stratification and pre-emptive treatment in clinical trials. Although patient/allele specific real-time quantitative polymerase chain reaction (qPCR) of IGH or BCL1-IGH clonal markers is the gold-standard method, its reliance on a standard curve for relative quantification limits quantification of low-level positivity within the 1E-4 to 1E-5 range; over half of positive MRD samples after treatment fall below the quantitative range (BQR) of the standard curve. Droplet digital PCR (ddPCR), in contrast, allows absolute quantification, including for samples with no baseline determination of tumor infiltration by multicolor flow cytometry (MFC), avoiding the need for a reference standard curve. Using updated, optimized, ddPCR criteria we compared it with qPCR in 416 MRD samples (and with MFC in 63), with over-representation (61%) of BQR results by qPCR, from a total of 166 patients from four prospective MCL clinical trials. ddPCR, qPCR and MFC gave comparable results in MRD samples with at least 0.01% (1E-4) positivity. ddPCR was preferable to qPCR since it provided more robust quantification at positivity between 1E-4 and 1E-5. Amongst 240 BQR samples with duplicate or triplicate analysis, 39% were positive by ddPCR, 49% negative and only 12% remained positive below quantifiable ddPCR limits. The prognostic relevance of ddPCR is currently under assessment in the context of prospective trials within the European MCL Network.
Optimal dynamic scheduling of wireless networked control systems (2019)

Wireless networked control system is gaining momentum in industrial cyber-physical systems, e.g., smart factory. Suffering from limited bandwidth and nondeterministic link quality, a critical challenge in its deployment is how to optimize the closed-loop control system performance as well as maintain stability. In order to bridge the gap between network design and control system performance, we propose an optimal dynamic scheduling strategy that optimizes performance of multi-loop control systems by allocating network resources based on predictions of both link quality and control performance at run-time. The optimal dynamic scheduling strategy boils down to solving a nonlinear integer programming problem, which is further relaxed to a linear programming problem. The proposed strategy provably renders the closed-loop system mean-square stable under mild assumptions. Its efficacy is demonstrated by simulating a four-loop control system over an IEEE 802.15.4 wireless network simulator - TOSSIM. Simulation results show that the optimal dynamic scheduling can enhance control system performance and adapt to both constant and variable network background noises as well as physical disturbance.
Thermal Optimization of Injection Molds Produced by Layered Manufacturing Techniques (2004)

Producing injection tooling with cooling channels of almost any form seems to be one of the most promising advantages of Layered Manufacturing Techniques (like Selective Laser Sintering). It could be efficiently exploited to achieve higher productivity or better quality parts in injection molding. Unfortunately, at the present time, the lack of data-processing tools to design optimal cooling systems still prevents us from fully benefiting from this new potential. The first objective of this paper is to present a methodology for the optimal design of cooling systems in three-dimensional injection molds. Our optimization process is based on a finite element model of the mold and on the standard gradient method. In the second part of this paper, we compare a conventional mold and a mold equipped with a cooling system optimized by means of the proposed methodology. The comparison is carried out thanks to an appropriate protocol. The conclusion is that the optimization of the cooling system doubled the productivity of the mold.
Approaches to target tractability assessment – a practical perspective (2018)

The assessment of the suitability of novel targets to intervention by different modalities, <italic>e.g.</italic> small molecules or antibodies, is increasingly seen as important in helping to select the most progressable targets at the outset of a drug discovery project.
The Photo-decomposition of 1-Azidopyrene in the Benzene Solution (1972)

Abstract 1-Nitrenopyrene (Py-N) was produced by the photo-decomposition of 1-azidopyrene (Py-N3) in the benzene solution at 77°K and at room temperature. At 77°K, Py-N was found to be stable, and its electronic absorption and ESR spectra were measured. The result shows that its ground state is triplet and the fine structure constant, D, is equal to 0.73 cm−1. At room temperature, 1-nitrenopyrene was found to be converted easily into 1,1′-trans-azopyrene (trans-Py-N=N–Py) in the oxygen-free benzene solution and into 1-nitropyrene (Py-NO2) in addition to Py-N=N-Py in the oxygen-containing benzene solution. The decay process of Py-N as a reaction intermediate and the formation processes of the reaction products were studied by the flash-photolysis technique, and from an analysis of the results, the rate constants at 23°C were determined to be 2.1×109lmol−1 sec−1 and 1.4×103sec−1 for 2Py–N→trans-Py-N=N–Py and for Py–N+O2→Py-NO2, respectively.
Receiver for DBS With Digital Audio Signals (1984)

The Direct Broadcasting Satellite (DBS) service has just started in Japan. The digital audio signals, which provide higher fidelity sound than FM broadcasting, are directly transmitted to homes by the satellite BS-2 with low noise, ghost free video signals.
ChemInform Abstract: RK. VON ELEMENTAREM SCHWEFEL MIT ORGANISCHEN VERBINDUNGEN 4. MITT. RK. VON N‐ARENSULFONYLSULFILIMINEN UND SULFOXIMINEN MIT SCHWEFEL UND DIARYLDISULFIDEN (1972)

Abstract Bei der Reaktion äquivalenter Mengen des Sulfilimins (I) und Schwefel in Chlor‐ benzol unter Rückflußkochen entsteht das Sulfid (II).
Abstract B024: Comprehensive biomarker profiling of matched primary and metastatic estrogen receptor positive breast cancers (2013)

Abstract Patients with newly diagnosed, early stage estrogen receptor positive (ER+) breast cancer often show disease free survival in excess of five years following surgery and systemic adjuvant therapy. As such, an important question is whether diagnostic tumor tissue from the primary lesion offers an accurate molecular portrait of the cancer post recurrence and thus may be used for predictive diagnostic purposes for patients with relapsed, metastatic disease. To address this question, we performed detailed biomarker analyses on matched, asynchronous primary and metastatic tumors from 77 patients with ER+ breast cancer. The class I phosphatidylinositol 3' kinase (PI3K) is thought to be an important driver in ER+ breast cancer and has been linked to acquired resistance to hormonal therapy. We thus examined whether mutations in PIK3CA and loss of PTEN showed differences in primary and metastatic samples. We also sought to look more broadly at markers reflective of proliferation, molecular subtype, and key receptors and signaling pathways. To accomplish this, we developed an analysis platform using the Fluidigm BioMark™ microfluidics system to measure the relative expression of 90 breast cancer related genes in formalin-fixed paraffin-embedded (FFPE) tissue. Application of this panel of assays to matched tumor pairs showed a very high concordance between primary and metastatic tissue, with generally few changes in mutation status, proliferative markers, or gene expression between matched samples. Thus, archival primary tumor tissue may still provide an accurate portrait of biomarker status in patients with disease recurrence. Citation Format: Jill M. Spoerke, Erica B. Schleifman, Rupal Desai, Yuanyuan Xiao, Cheryl Wong, Ilma Abbas, Carol O'Brien, Rajesh Patel, Teiko Sumiyoshi, Ling Fu, Rachel Tam, Hartmut Koeppen, Timothy Wilson, Rajiv Raja, Garret M. Hampton, Mark R. Lackner. Comprehensive biomarker profiling of matched primary and metastatic estrogen receptor positive breast cancers. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Breast Cancer Research: Genetics, Biology, and Clinical Applications; Oct 3-6, 2013; San Diego, CA. Philadelphia (PA): AACR; Mol Cancer Res 2013;11(10 Suppl):Abstract nr B024.
Front Matter: Volume 8926 (2014)

This PDF file contains the front matter associated with SPIE Proceedings Volume 8926, including the Title Page, Copyright information, Table of Contents, Invited Panel Discussion, and Conference Committee listing.
Printed Circuit Board Electrodes for Transmural Cardiac Mapping (2006)

Plunge needle recording techniques have provided valuable insights into transmural activation in cardiac tissue. Construction of plunge needles has been a costly and time intensive endeavor. Plunge needles constructed with standard printed circuit board (PCB) technology and methods are outlined. PCB plunge needles are less expensive in terms of raw materials and time required for construction than hypodermic stock or epoxy plunge needles. Tested PCB plunge needles recorded signals comparable to signals recorded by other plunge needles. PCB plunge needles provide an economical and rapid alternative to previously published techniques for plunge needle design.
<title>Endoscopically controlled laser lithotripsy of salivary gland calculi and the problem of fiber wear</title> (1992)

Seventy-three patients suffering from sialolithiasis were treated by endoscopically controlled, laser-induced lithotripsy (LIL). The non-sedated patients were treated under local anaesthetic with specially developed endoscopes with a diameter < 1.8 mm. A laser fiber was then positioned on the concrement which was finally fragmented while being monitored using a pulsed excimer laser (308 nm), a dye laser (504 nm), and an Alexandrite laser (755 nm). In all cases a complete fragmentation of the stone was achieved. This approach to laser lithotripsy of salivary gland calculi with endoscopic monitoring represents a novel method which permits an out-patient treatment under local anaesthetic with a minimum inconvenience to the patient. In `in vitro' experiments the effectiveness of the stone destruction (plasma formation rate, the number of pulses required to fragment the stone, and fragment size) were tested. The quantitative assessment of the fiber end surface during direct contact and the determination of the shape and size of the broken fiber pieces have been tested. A possibility to avoid the fiber wear was developed. It's called `Index Matching' and needs a special endoscopic integrated flushing system.
Sub-100 nm lithography using KrF exposure with multiple development method (2003)

Describes a novel resist process technique, using a chemically amplified resist with a multiple development method for improving resolution of photolithography. By means of this technique, a grating resist pattern whose frequency is more than a cutoff frequency of the optics (vc=1/Pc=2NA//spl lambda/) can be delineated using a conventional exposure system. This process uses a resist that allows either positive or negative imaging depending on the selection of a developer solvent.
Edge Detection And Skeletonization Using Quantized Localized Phase (2009)

Publication in the conference proceedings of EUSIPCO, Glasgow, Scotland, 2009
Characterization and novel low-temperature reactions of FeCH2 and N2FeCH2 (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCharacterization and novel low-temperature reactions of FeCH2 and N2FeCH2Sou Chan. Chang, Robert H. Hauge, Zakya H. Kafafi, John L. Margrave, and W. E. BillupsCite this: J. Am. Chem. Soc. 1988, 110, 24, 7975–7980Publication Date (Print):November 1, 1988Publication History Published online1 May 2002Published inissue 1 November 1988https://pubs.acs.org/doi/10.1021/ja00232a004https://doi.org/10.1021/ja00232a004research-articleACS PublicationsRequest reuse permissionsArticle Views150Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
High spatial density nanocrystal formation using thin layer of amorphous Si0.7Ge0.3 deposited on SiO2 (2000)

The process to make nanocrystals with an average size &amp;lt;5 nm and a spatial density &amp;gt;1012/cm2 was proposed using agglomeration and partial oxidation of thin amorphous Si0.7Ge0.3 layer deposited in between the SiO2 layers by low pressure chemical vapor deposition. The reason to use an amorphous layer is to make it possible to deposit a thin continuous layer with a thickness of less than 5 nm. Si0.7Ge0.3 alloy layer was used to control the spatial density of the nanocrystals by using selective oxidation of Si in Si0.7Ge0.3 alloy layer. The single electron memory, similar to a flash type memory device was fabricated using these Si0.7Ge0.3 nanocrystals. The Coulomb blockade effect could be clearly observed at room temperature with a threshold voltage shift of about 2.4 V, which demonstrated the formation of nanocrystals with a high spatial density.
Absolute determination of the wavelength and spectrum of an extreme-ultraviolet beam by a Young’s double-slit measurement (2002)

The interference pattern produced by irradiation of a pair of pinholes with a beam contains information on both the spatial and the temporal coherence properties of the beam, as well as its power spectrum. We demonstrate experimentally for what is believed to be the first time that the spectrum of an extreme-ultraviolet (EUV) beam can be obtained from a measurement of the interference pattern produced by a pinhole pair. This approach offers a convenient method of making absolute wavelength and relative spectral intensity calibrations in the EUV.
Three Level T-Type Buck-Boost Voltage Source Inverter (2019)

This paper presents a three level T-type buck-boost voltage source inverter ( 3LT <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> -BBVSI) to be used with distributed generation systems. The 3LT <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> -BBVSI topology combines a three level T-type inverter with DC-DC boost converter in one power stage; thus, high boosting gain along with multi-level shaping of the output voltage are acquired. Compared to other single-stage boost inverters, the proposed one achieves significant reduction in the passive components count; thus, reduced size along with higher efficiency can be realized. In this paper, the topology description along with the steady state analysis are presented. The operation of 3LT <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> -BBVSI is verified using OPAL-RT LAB tools. In addition, experimental results using 3LT <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> -BBVSI prototype are introduced.
X-METRA-ADA: Cross-lingual Meta-Transfer Learning Adaptation to Natural Language Understanding and Question Answering (2021)

Multilingual models, such as M-BERT and XLM-R, have gained increasing popularity, due to their zero-shot cross-lingual transfer learning capabilities. However, their generalization ability is still inconsistent for typologically diverse languages and across different benchmarks. Recently, meta-learning has garnered attention as a promising technique for enhancing transfer learning under low-resource scenarios: particularly for cross-lingual transfer in Natural Language Understanding (NLU). In this work, we propose X-METRA-ADA, a cross-lingual MEta-TRAnsfer learning ADAptation approach for NLU. Our approach adapts MAML, an optimization-based meta-learning approach, to learn to adapt to new languages. We extensively evaluate our framework on two challenging cross-lingual NLU tasks: multilingual task-oriented dialog and typologically diverse question answering. We show that our approach outperforms naive fine-tuning, reaching competitive performance on both tasks for most languages. Our analysis reveals that X-METRA-ADA can leverage limited data for faster adaptation.