gebhart/patrepeval huggingface dataset:
Éditorial (2010)

Pr Alain Prochiantz © P. Imbert, Collège de France Pr John Scheid © P. Imbert, Collège de France Pr Jean-Christophe Yoccoz © P. Imbert, Collège de France « Enseigner la recherche en train de se faire », telle est la mission du Collège de France. Il ne s’en acquitte pas seulement en dispensant ses cours et séminaires et en les diffusant par le biais d’internet auprès du public le plus large. Le Collège de France s’attache également à la formation de jeunes chercheurs en les accueillant, pour...
Using real-time adaptive noise masking to mitigate ambient interferences (2011)

A real-time adaptive noise masking method for ambient interference mitigation is proposed. The noise masker is implemented below the auditory masking surface of concurrent music and is thus inaudible. The noise masking parameters are also adapted to ambient interferences and room acoustics to improve masking efficiency.
Molecular mechanism and therapeutic implications of selinexor (KPT-330) in liposarcoma (2016)

Exportin-1 mediates nuclear export of multiple tumor suppressor and growth regulatory proteins. Aberrant expression of exportin-1 is noted in human malignancies, resulting in cytoplasmic mislocalization of its target proteins. We investigated the efficacy of selinexor against liposarcoma cells both in vitro and in vivo. Exportin-1 was highly expressed in liposarcoma samples and cell lines as determined by immunohistochemistry, western blot, and immunofluorescence assay. Knockdown of endogenous exportin-1 inhibited proliferation of liposarcoma cells. Selinexor also significantly decreased cell proliferation as well as induced cell cycle arrest and apoptosis of liposarcoma cells. The drug also significantly decreased tumor volumes and weights of liposarcoma xenografts. Importantly, selinexor inhibited insulin-like growth factor 1 (IGF1) activation of IGF-1R/AKT pathway through upregulation of insulin-like growth factor binding protein 5 (IGFBP5). Further, overexpression and knockdown experiments showed that IGFBP5 acts as a tumor suppressor and its expression was restored upon selinexor treatment of liposarcoma cells. Selinexor decreased aurora kinase A and B levels in these cells and inhibitors of these kinases suppressed the growth of the liposarcoma cells. Overall, our study showed that selinexor treatment restored tumor suppressive function of IGFBP5 and inhibited aurora kinase A and B in liposarcoma cells supporting the usefulness of selinexor as a potential therapeutic strategy for the treatment of this cancer.
ANTIBODIES TO A NOVEL FLAGELLIN (CBIR1) ADDS CLINICAL UTILITY TO THE DIAGNOSIS AND DIFFERENTIATION OF PEDIATRIC IBD (2005)

Background: Approximately 2/3 of IBD patients are positive for antibodies to microbial and auto-antigens. A novel antibody; anti-CBir1, may have unique diagnostic properties and phenotypic associations in children. The Western Regional Pediatric IBD Research Alliance examined the added utility of anti-CBir1 in the diagnosis and differentiation of pediatric IBD patients as compared to previously defined antibodies: ASCA, OmpC, I2 and pANCA. Methods: Sera from 331 pediatric IBD patients (111 UC, 220 CD) were tested by ELISA for anti-OmpC, anti-I2, ASCA, anti-Cbir1 and pANCA. Quantitative and qualitative expression of antibody markers was evaluated. Results: Anti-CBir1 was present in 55% of CD vs. 15% of UC (p < 0.001). 41% of anti-CBir1 (+) UC patients were also positive for >1 CD-related antibody. Anti-CBir1 was present in 53% of ASCA(−) CD patients and in 52% (31/60) of patients negative for all antibodies. The most CBir1 reactive CD subset was OmpC+/I2+ (74%, median = 49) and least reactive was ASCA + (56%, median = 31). 13.5% of pANCA (+) only UC patients were anti-CBir1 (+) as compared to 35% of pANCA(+) only CD patients (p = 0.03). Both pANCA and anti-CBir1 levels were higher in pANCA (+) CD vs. UC (median pANCA: 46.6 vs. 70.0; p = 0.003, and median anti-CBir1: 21 vs. 12 p < 0.0001). Conclusions: Anti-CBir1 increased detection of CD cases negative for all other antibodies. Cbir1 reactivity added to the differentiation of pANCA+ CD from pANCA+ UC and can minimize misdiagnosed CD colitis patients. Both the presence and magnitude of anti-CBir1 reactivity adds to the clinical utility of presently known antibodies in pediatric IBD.
Effectiveness of Androgen-Deprivation Therapy and Radiotherapy for Older Men With Locally Advanced Prostate Cancer (2015)

Older men with locally advanced or screen-detected high-risk prostate cancer who receive ADT alone risk decrements in cause-specific and overall survival.
ChemInform Abstract: ORGANOBISCUPRATES. A SINGLE‐STEP SPIROANNULATION METHOD (1977)

Abstract Aus den Lw‐Dilithiopolymethylenen (I) erhält man mit Cu(I)‐thiophenolat (II) die Komplexe (III), die mit Benzoylchlorid zu den Diketonen (Va) und (Vb) führen.
Theoretical Insights into the Interaction of Oxygenated Organic Molecules and Cobalt(II) Precursor with γ-Al2O3Surfaces (2018)

The interaction of two common oxygenates, ethylene glycol (EG) and acetic acid (AA), with the main exposed (100) and (110) surfaces of γ-Al2O3 are investigated by quantifying the thermochemistry of the drying process. Using density functional theory (DFT) calculations, we determine adsorption free energies and identify the adsorption modes and sites for both molecules interacting with the (100) and (110) surfaces of γ-Al2O3 at various coverages. While the affinity of both molecules is stronger for the (100) surface after drying, EG is more strongly adsorbed on alumina surfaces than AA. EG preferentially interacts through hydrogen bonds on the hydroxyl nests of the (100) and (110) surfaces, while it may also interact through Al–O bonds on the (110) surface at low coverage. AA is predominantly deprotonated and interacts as acetate anions through hydrogen bonds on the (110) and (100) surfaces and through Al–O bonds on the (100) surface at low coverage. We then propose a quantitative comparison of the interaction of Co2+ hexaaquo precursor with the same γ-Al2O3 surfaces. The adsorption configurations of the two organic molecules which may hinder the epitaxial growth of cobalt oligomers on alumina surfaces are identified. However, the thermodynamic analysis shows that EG and AA are less stable than the Co precursors after drying. The strong stabilization of Co precursors is attributed to its epitaxial relationship with the dried alumina surfaces as found in [Angew. Chem. Int. Ed. 2015, 54, 6824–6827] and also to a favorable entropy change during the drying process (vapor release and nitrate counterion decomposition in the gas phase). We finally discuss how these effects can be circumvented by changing the conditions of preparation and drying.
Inactivation of Intergenic Enhancers by EBNA3A Initiates and Maintains Polycomb Signatures across a Chromatin Domain Encoding CXCL10 and CXCL9 (2013)

Epstein-Barr virus (EBV) causes a persistent infection in human B cells by establishing specific transcription programs to control B cell activation and differentiation. Transcriptional reprogramming of EBV infected B cells is predominantly driven by the action of EBV nuclear antigens, among them the transcriptional repressor EBNA3A. By comparing gene expression profiles of wt and EBNA3A negative EBV infected B cells, we have previously identified a broad array of cellular genes controlled by EBNA3A. We now find that genes repressed by EBNA3A in these cells are significantly enriched for the repressive histone mark H3K27me3, which is installed by Polycomb group (PcG) proteins. This PcG-controlled subset of genes also carries H3K27me3 marks in a variety of other tissues, suggesting that the commitment to PcG silencing is an intrinsic feature of these gene loci that can be used by EBNA3A. In addition, EBNA3A targets frequently reside in co-regulated gene clusters. To study the mechanism of gene repression by EBNA3A and to evaluate the relative contribution of PcG proteins during this process, we have selected the genomic neighbors CXCL10 and CXCL9 as a model for co-repressed and PcG-controlled genes. We show that EBNA3A binds to CBF1 occupied intergenic enhancers located between CXCL10 and CXCL9 and displaces the transactivator EBNA2. This impairs enhancer activity, resulting in a rapid transcriptional shut-down of both genes in a CBF1-dependent manner and initiation of a delayed gain of H3K27me3 marks covering an extended chromatin domain. H3K27me3 marks increase gradually and are maintained by EBNA3A. Our study provides direct evidence that repression by EBNA3A requires CBF1 and that EBNA3A and EBNA2 compete for access to CBF1 at identical genomic sites. Most importantly, our results demonstrate that transcriptional silencing by EBNA3A precedes the appearance of repressive PcG marks and indicate that both events are triggered by loss of enhancer activity.
Towards the Total Synthesis of Saponaceolides: Synthesis ofcis-2,4-Disubstituted 3,3-Dimethylmethylenecyclohexanes (1999)

Controlling diastereoselectivity by metal coordination: In the case of 3,3-dimethylmethylenecyclohexanes 2—a structural unit present in many interesting natural products—the thermodynamically less stable cis-2,4-disubstituted compounds become available through a cyclization event wherein the configuration is determined by a carbopalladation step. Both the cycloisomerization of 1,7-enynes 1 and the intramolecular Heck-type reaction of compounds of type 3 provide the cis product as the major product.
Fabrication of double metal feram without degradation of remnant polarization by using Ir/IrOx capacitor contact barrier layer (2000)

Abstract The capacitor contact barrier (CCB) structure was introduced to prevent both the Pt/Al reaction and the Ti effect to a SBT capacitor. TiN CCB layer could not perfectly block the Pt/Al reaction. And ferroelectric properties of SBT capacitor were degraded during back-end processes. So, we applied a new Ir/IrOx layer to the CCB layer. The SBT capacitor with the Ir/IrOx CCB layer exhibited higher delta polarization (dP∼15 μC/cm2) after the metal-2 etching process, compared with the value in the case of the TiN CCB layer (dP∼12μC/ cm2). Moreover, the dP uniformity was improved to 4% when we used the Ir/IrOx CCB layer, from the ∼20% of the TiN CCB layer. And the defect formed by the Pt/Al reaction was not found in the Ir/IrOx CCB layer structure.
Supplementary Figures 1-4 from DCAMKL-1 Regulates Epithelial–Mesenchymal Transition in Human Pancreatic Cells through a <i>miR-200a</i>–Dependent Mechanism (2023)

Supplementary Figures 1-4 from DCAMKL-1 Regulates Epithelial–Mesenchymal Transition in Human Pancreatic Cells through a &lt;i&gt;miR-200a&lt;/i&gt;–Dependent Mechanism
Free-Breathing Echo-Planar Imaging Based Diffusion-Weighted Magnetic Resonance Imaging of the Liver With Prospective Acquisition Correction (2008)

Objective: To evaluate soft tissue contrast and image quality of a respiratory-triggered echo-planar imaging based diffusion-weighted sequence (EPI-DWI) with different b values for magnetic resonance imaging (MRI) of the liver. Methods: Forty patients were examined. Quantitative and qualitative evaluation of contrast was performed. Severity of artifacts and overall image quality in comparison with a T2w turbo spin-echo (T2-TSE) sequence were scored. Results: The liver-spleen contrast was significantly higher (P < 0.05) for the EPI-DWI compared with the T2-TSE sequence (0.47 ± 0.11 (b50); 0.48 ± 0.13 (b300); 0.47 ± 0.13 (b600) vs 0.38 ± 0.11). Liver-lesion contrast strongly depends on the b value of the DWI sequence and decreased with higher b values (b50, 0.47 ± 0.19; b300, 0.40 ± 0.20; b600, 0.28 ± 0.23). Severity of artifacts and overall image quality were comparable to the T2-TSE sequence when using a low b value (P > 0.05), artifacts increased and image quality decreased with higher b values (P < 0.05). Conclusion: Respiratory-triggered EPI-DWI of the liver is feasible because good image quality and favorable soft tissue contrast can be achieved.
Complex conductivity porosimetry during unconfined soil compression (2021)

The unconfined compressive strength (UCS) test is one of the most utilized geotechnical soil analysis techniques for soil stability evaluation. Understanding soil pore size changes during a UCS test is important for estimating soil saturation changes and can help in real-time estimation of soil mechanical state (from liquid to a plastic, to a semisolid, and to a solid state). Here, we performed a UCS test on a synthetic soil mixture of silica sand (98%) and fine kaolin powder (2%) which was saturated below its liquid limit (Sw = 68%). Concurrently, we measured complex conductivity signals of the soil associated with pore size distribution changes resulting from compression. Our results show that soil deformation and failure during a UCS test have measurable impacts on complex conductivity signals of the soil. The pore size distribution of the soil was estimated from a Debye decomposition inversion performed on the measured complex conductivity spectra. On average, an order of magnitude reduction in the dominant pore size of the soil was estimated from complex conductivity measurements. Our findings show that complex conductivity measurements might be used in conjunction with geotechnical measurements for estimating soil porosity and pore size distribution changes.
Updated Technology to Produce Highly Immunogenic Dendritic Cell-derived Exosomes of Clinical Grade (2010)

Dendritic cell-derived exosomes (Dex) are nanovesicles bearing major histocompatibility complexes promoting T-cell-dependent antitumor effects in mice. Two phase I clinical trials aimed at vaccinating cancer patients with peptide-pulsed Dex have shown the feasibility and safety of inoculating clinical-grade Dex, but have failed to show their immunizing capacity. These low immunogenic capacities have led us to develop second-generation Dex with enhanced immunostimulatory properties. Here, we show that interferon-γ is a key cytokine conditioning the dendritic cell to induce the expression of CD40, CD80, CD86, and CD54 on Dex, endowing them with direct and potent peptide-dependent CD8(+) T-cell-triggering potential in vitro and in vivo. In this study, we describe the clinical grade process to manufacture large-scale interferon-γ-Dex vaccines and their quality control parameters currently used in a phase II trial.
Conjoint use of coded-aperture collimators and MLEM algorithm: Towards large blood vessels reconstruction at 511 KEV (2008)

In this paper, we propose a novel approach to improve the trade-off between the spatial resolution and the sensitivity of existing nuclear imaging systems in emission tomography for 511 keV-photons. Although emission tomography suffers from the low amount of emitted photons in the object, partial transparency of collimators and low sensitivity of detectors, we are able to reconstruct radioactive spatial distribution from projections obtained through a specifically designed coded-aperture collimator, with a MLEM-algorithm. We address both the selection of the collimator and the reconstruction approach. Very promising experiments towards 3D-vessels reconstruction demonstrate the potentials of our approach.
Youngiibacter fragilis gen. nov., sp. nov., isolated from natural gas production-water and reclassification of Acetivibrio multivorans as Youngiibacter multivorans comb. nov. (2013)

A taxonomic study employing a polyphasic approach was performed on a novel anaerobic bacterium isolated from natural gas production-water. The bacterium stained Gram-negative and consisted of non-motile, non-spore-forming, rod-shaped cells. Products of glucose or starch fermentation were ethanol, CO2, formate, acetate and H2. The predominant fatty acids were C16 : 0 ALDE and summed feature 3 comprising C16 : 1ω7c and/or C16 : 1ω6c. The DNA G+C content was 45.5 mol%. 16S rRNA gene sequence analysis demonstrated that the nearest phylogenetic neighbours of the novel strain were Acetivibrio multivorans DSM 6139(T) (98.5 %) and Proteiniclasticum ruminis JCM 14817(T) (95.4 %). The DNA-DNA hybridization value between the novel organism and Acetivibrio multivorans PeC1 DSM 6139(T) was determined to be only 30.2 %, demonstrating the separateness of the two species. Based on phylogenetic, phenotypic and chemotaxonomic evidence that clearly distinguished strain 232.1(T) from Proteiniclasticum ruminis and other close relatives, it is proposed that the novel isolate be classified as representing a novel species of a new genus within the family Clostridiaceae, Youngiibacter fragilis gen. nov., sp. nov. The type strain of the type species is 232.1(T) ( = ATCC BAA-2257(T) = DSM 24749(T)). In addition, Acetivibrio multivorans is proposed to be reclassified as Youngiibacter multivorans comb. nov.
HDFL: A Heterogeneity and Client Dropout-Aware Federated Learning Framework (2023)

Cross-device Federated Learning (FL) enables training machine learning (ML) models on private data that is heterogeneously distributed over many IoT end devices without violating privacy requirements. Clients typically vary significantly in data quality, hardware resources and stability, which results in challenges such as increased training times, higher resource costs, sub-par model performance and biased training. Existing works tend to address each of these challenges in isolation, but overlook how they might impact each other holistically. We perform a first of its kind characterization study that empirically demonstrates how these properties interact with each other to impact important performance metrics such as model error, fairness, resource cost and training time. We then propose a method called HDFL based on our observations, which is the first framework to our knowledge that comprehensively considers the multiple aforementioned important challenges of practical FL systems. We implement HDFL on a real distributed system and evaluate it on multiple benchmark datasets which show that HDFL achieves better Pareto frontier compared to both the state-of-the-practice and state-of-the-art systems with up to 4-10% better model accuracy, 33% improved good-intent fairness, 63% lower cost, and 17% faster training time.
Active queue management with flow proportional buffering (2003)

Abstract Most active queue management schemes maintain an average of the queue length which they use together with a number of queue thresholds to detect congestion. However, the setting of the queue thresholds is problematic because the required buffer size for good sharing among TCP connections is dependent on the number of TCP connections using the buffer. This paper describes an improved active queue management scheme which dynamically changes its threshold settings as the number of connections and system load changes. This technique allows network devices to effectively control packet losses and TCP timeouts while maintaining high link utilization. Copyright © 2003 John Wiley &amp;Sons, Ltd.
Molecular Engineering of Conjugated Polybenzothiadiazoles for Enhanced Hydrogen Production by Photosynthesis (2016)

Abstract The search for metal‐free organic photocatalysts for H 2 production from water using visible light remains a key challenge. Reported herein is a molecular structural design of pure organic photocatalysts, derived from conjugated polybenzothiadiazoles, for photocatalytic H 2 evolution using visible light. By alternating the substitution position of the electron‐withdrawing benzothiadizole unit on the phenyl unit as a comonomer, various polymers with either one‐ or three‐dimensional structures were synthesized and the effect of the molecular structure on their catalytic activity was investigated. Photocatalytic H 2 evolution efficiencies up to 116 μmol h −1 were observed by employing the linear polymer based on a phenyl‐benzothiadiazole alternating main chain, with an apparent quantum yield (AQY) of 4.01 % at 420 nm using triethanolamine as the sacrificial agent.
Table S3 from Targeting the MYCN–PARP–DNA Damage Response Pathway in Neuroendocrine Prostate Cancer (2023)

&lt;p&gt;Differential expression results for DDR-M genes in Beltran's and MDA PDX RNAseq datasets.&lt;/p&gt;
Detecting failures of the glucose sensor-insulin pump system: Improved overnight safety monitoring for Type-1 diabetes (2011)

New sensors for real-time continuous glucose monitoring (CGM) and pumps for continuous subcutaneous insulin infusion (CSII), possibly mounted on the same device, opened new scenarios for Type-1 diabetes treatment. However, possible failures of either CGM or CSII can expose diabetic patients to risks that can be dangerous especially overnight. In this contribution we present a proof-of-concept method, developed in a state-space context and implemented through a Kalman estimator, to detect in real time possible overnight failures of the sensor-pump system by simultaneously using CGM and CSII data. The method is tested on two simulated and one real subject. Results show that the method is able to correctly generate alerts for sensor-pump failures and stimulates further investigation on its development.
Abstract 15355: Evaluating the Electrocardiographic Characteristics of Transgender Patients Undergoing Gender-Affirming Hormone Therapy With Artificial Intelligence (2022)

Evaluating the Electrocardiographic Characteristics of Transgender Patients Undergoing Gender-affirming Hormone Therapy with Artificial Intelligence Introduction: An artificial intelligence (AI) electrocardiogram (ECG) algorithm has been demonstrated to identify a patient’s birth designated sex with 90.4% accuracy with an AUC = 0.97. However, the algorithm has not been evaluated in transgender and gender diverse individuals. We aimed to determine how the algorithm output varies among transgender individuals seen at the Mayo Clinic Transgender and Intersex Specialty Care Clinic (TISCC) who are undergoing gender-affirming hormonal treatment (GAHT). Methods: We applied the algorithm (which assessed the probability of “male” between 0 and 1, with &lt; 0.5 considered as “female” and &gt; 0.5 as “male”) to ECGs obtained from patients in the TISCC before and after the initiation of GAHT. GAHT frequently involves the use of testosterone in transgender men, and estrogen and anti-androgen agents in transgender women. Patient characteristics, including the date of the initiation of GAHT, were collected through chart review. Results: Among transgender women, the AI model probability of “male” decreased from 0.84± 0.25 (12/86 classified as males) to 0.59±0.36 (68/173 classified as male) with GAHT (p &lt; 7.8e-10). Among transgender men, the AI model probability of “male” increased from 0.16 ± 0.28 (7/47 classified as male) to 0.41 ±0.38 (22/53 classified as male) with GAHT (p &lt; 2.4e-4). Conclusion: After GAHT initiation, the Mayo Clinic AI ECG algorithm assigns a higher probability of being male among transgender men and a lower probability of being male among transgender women. These findings warrant further investigation into the electrocardiographic differences across genders and the effects of GAHT on the human heart.