gebhart/patrepeval huggingface dataset:
Second-Order Configuration of Local Features for Geometrically Stable Image Matching and Retrieval (2014)

Local features offer high repeatability, which supports efficient matching between images, but they do not provide sufficient discriminative power. Imposing a geometric coherence constraint on local features improves the discriminative power but makes the matching sensitive to anisotropic transformations. We propose a novel feature representation approach to solve the latter problem. Each image is abstracted by a set of tuples of local features. We revisit affine shape adaptation and extend its conclusion to characterize the geometrically stable feature of each tuple. The representation thus provides higher repeatability with anisotropic scaling and shearing than found in previous research. We develop a simple matching model by voting in the geometrically stable feature space, where votes arise from tuple correspondences. To make the required index space linear as regards the number of features, we propose a second approach called a centrality-sensitive pyramid to select potentially meaningful tuples of local features on the basis of their spatial neighborhood information. It achieves faster neighborhood association and has a greater robustness to errors in interest point detection and description. We comprehensively evaluated our approach using Flickr Logos 32, Holiday, Oxford Buildings, and Flickr 100 K benchmarks. Extensive experiments and comparisons with advanced approaches demonstrate the superiority of our approach in image retrieval tasks.
Universal Numerical Encoder and Profiler Reduces Computing's Memory Wall with Software, FPGA, and SoC Implementations (2013)

In the multicore era, the time to computational results is increasingly determined by how quickly operands are accessed by cores, rather than by the speed of computation per operand. From high-performance computing (HPC) to mobile application processors, low multicore utilization rates result from the slowness of accessing off-chip operands, i.e. the memory wall. The APplication AXcelerator (APAX) universal numerical encoder reduces computing's memory wall by compressing numerical operands (integers and floats), thereby decreasing CPU access time by 3:1 to 10:1 as operands stream between memory and cores. APAX encodes numbers using a low-complexity algorithm designed both for time series sensor data and for multi-dimensional data, including images. APAX encoding parameters are determined by a profiler that quantifies the uncertainty inherent in numerical datasets and recommends encoding parameters reflecting this uncertainty. Compatible software, FPGA, and systemon-chip (SoC) implementations efficiently support encoding rates between 150 MByte/sec and 1.5 GByte/sec at low power. On 25 integer and floating-point datasets, we achieved encoding rates between 3:1 and 10:1, with average correlation of 0.999959, while accelerating computational "time to results."
Shear Forces from Flow Are Responsible for a Distinct Statistical Signature of Adherent Microbubbles in Large Vessels (2013)

Real-time ultrasound-based targeted molecular imaging in large blood vessels holds promise for early detection and diagnosis of stroke risk by identifying early markers for atherosclerosis prior to plaque formation. Singular spectrum-based targeted molecular (SiSTM) imaging is a recently proposed method that uses changes in statistical dimensionality-quantified by a normalized singular spectrum area (NSSA)-to image receptor-ligand-bound adherent microbubbles. However, the precise physical mechanism responsible for the distinct statistical signature was previously unknown. In this study, in vitro flow phantom experiments were performed to elucidate the physical mechanism in large blood vessel environments. In the absence of flow, an increase in the NSSA of adherent microbubbles with respect to tissue was not observed with increased microbubble concentration or pulse length (p > .23; n = 5) but was observed with increased flow rate (p < .01; n = 10). When observing the dynamics of the adherent microbubble statistics, a good correlation was observed between the NSSA and the derivative of image intensity (R2 > .97). In addition, a monotonic relationship between the NSSA and decorrelation was demonstrated. These findings confirm the hypothesis that the statistical signature of adherent microbubbles is derived from frame-to-frame decorrelation, which is induced by flow shear forces.
Quantum information processing by nuclear magnetic resonance spectroscopy (2002)

Nuclear magnetic resonance (NMR) is a direct macroscopic manifestation of the quantum mechanics of the intrinsic angular momentum of atomic nuclei. It is best known for its extraordinary range of applications, which include molecular structure determination, medical imaging, and measurements of flow and diffusion rates. Most recently, liquid-state NMR spectroscopy has been found to provide a powerful experimental tool for the development and evaluation of the coherent control techniques needed for quantum information processing. This burgeoning new interdisciplinary field has the potential to achieve cryptographic, communications, and computational feats far beyond what is possible with known classical physics. Indeed, NMR has made the demonstration of many of these feats sufficiently simple to be carried out by high school summer interns working in our laboratory (see the last two authors). In this paper the basic principles of quantum information processing by NMR spectroscopy are described, along with several illustrative experiments suitable for incorporation into the undergraduate physics curriculum. These experiments are spin–spin interferometry, an implementation of the quantum Fourier transform, and the quantum simulation of a harmonic oscillator.
Braille Displays: A 4 V Operation, Flexible Braille Display Using Organic Transistors, Carbon Nanotube Actuators, and Organic Static Random‐Access Memory (Adv. Funct. Mater. 21/2011) (2011)

A 4-V operational organic Braille display is developed by Takao Someya and coworkers on page 4019, by integrating an organic static random-access-memory (SRAM) array with a carbon nanotube (CNT)-based actuator and an organic thin film tranistor (TFT) driver. Taking advantage of new organic materials and process engineering, an actuator displacement of 300 μm has been achieved within 4-V operation in air, a size that is large enough for a blind person to recognize whether individual dots are in an up or down state.
Supplementary Methods and Data (posted 7/5/2011) from Characterization of <i>KRAS</i> Rearrangements in Metastatic Prostate Cancer (2023)

Supplementary Methods and Data (posted 7/5/2011) from Characterization of &lt;i&gt;KRAS&lt;/i&gt; Rearrangements in Metastatic Prostate Cancer
MILDRONATE: AN ANTIISCHEMIC DRUG WITH MULTIPLE INDICATIONS (2006)

Summary Mildronate (3-(2,2,2-trimethylhydrazine)propionate; THP; MET-88; meldonium, quaterine) is an anti-ischemic drug developed in the Latvian Institute of Organic Synthesis. Mildronate was designed as a promising inhibitor of carnitine biosynthesis aimed to prevent accumulation of cytotoxic intermediate products of fatty acid beta- oxidation in ischemic tissues and to block this highly oxygenconsuming process. Actually Mildronate is used in several countries in cardiology (treatment of chronic heart ischemic disease, stable angina pectoris, chronic heart failure, functional disorders of heart and vessels, cardiomyopathy, heart infarction), neurology (acute and chronic ischemic brain circulation disorders, decreased work capabilities, physical and emotional overload, recovery period after various diseases), pulmonology (bronchial asthma and obstructive bronchitis), narcology (abstinence syndrome in chronic alcoholism), ophthalmology (hemophthalm and retina haemorrhages of different aetiology, thrombosis of central vein and its branches in retina, diabetic and hypertonic retinopathies). The main mechanism of action of Mildronate is based on carnitine biosynthesis inhibition aimed to prevent accumulation of cytotoxic intermediate products of fatty acid beta- oxidation in ischemic tissues and to block this highly oxygen-consuming process. Alternatively the drug acts via stimulation of the nitric oxide production in the vascular endothelium through a modification of the γ-butyrobetaine and γ-butyrobetaine ester pools. The present review will summarize data on the Mildronate on different indications of the drug and its mechanisms of action.
AUGMENTATION OF ACTH-RELEASING ACTIVITY OP SYNTHETIC CORTICOTROPIN RELEASING FACTOR (CRF) BY VASOPRESSIN IN WOMEN (1983)

In order to study the interaction between vasopressin (VP) and hypothalamic corticotropin releasing factor (CRF) on the release of ACTH, VP and CRF were administered separately and in combination to normal cycling women. The combined hormones raised plasma ACTH levels higher than the sum of the separate responses and 5 times more than CRF alone. This study reveals for the first time synergism between VP and CRF in their ACTH releasing effects in humans.
ChemInform Abstract: Carotenoid Synthesis. Coupling Reactions. Part 1. Enol Ether and Aldol Condensations (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Telcordia qualification and beyond: reliability of today"s polymer photonic components (2005)

We report on the reliability of state-of-the-art integrated dynamic polymeric photonic components developed for the telecommunications market. Tests conducted include full Telcordia GR-1209-CORE/GR-1221-CORE qualification, as well as accelerated aging tests that significantly exceed Telcordia requirements, such as aging at extreme temperature (5000 hours at 175°C) and optical power (6000 hours at 1.5 W of 1550 nm light). The types of components we describe include variable optical attenuator arrays, intelligent optical cross-connects, and fully reconfigurable optical add/drop multiplexers.
Synthesis, Characterization, and Application of Indolo[3,2-b]carbazole Semiconductors (2007)

The synthesis, characterization, and field-effect transistor (FET) properties of new indolo[3,2-b]carbazoles are described. In particular, an extensive characterization of their crystal structures has revealed the importance of the nature of the side chains (alkyl, phenyl, thienyl substituents) on their solid-state organization. These organic materials have exhibited p-type FET behavior with hole mobilities as high as 0.2 cm2 V(-1) s(-1) with an on/off current ratio higher than 10(6). Best results were obtained with phenyl-substituted indolo[3,2-b]carbazoles since the presence of phenyl substituents seems to allow efficient overlap between the oligomeric molecules. More importantly, FET properties were kept constant during several months in air.
Natural mutations of the anti-Mullerian hormone type II receptor found in persistent Mullerian duct syndrome affect ligand binding, signal transduction and cellular transport (2009)

The anti-Müllerian hormone type II (AMHRII) receptor is the primary receptor for anti-Müllerian hormone (AMH), a protein produced by Sertoli cells and responsible for the regression of the Müllerian duct in males. AMHRII is a membrane protein containing an N-terminal extracellular domain (ECD) that binds AMH, a transmembrane domain, and an intracellular domain with serine/threonine kinase activity. Mutations in the AMHRII gene lead to persistent Müllerian duct syndrome in human males. In this paper, we have investigated the effects of 10 AMHRII mutations, namely 4 mutations in the ECD and 6 in the intracellular domain. Molecular models of the extra- and intracellular domains are presented and provide insight into how the structure and function of eight of the mutant receptors, which are still expressed at the cell surface, are affected by their mutations. Interestingly, two soluble receptors truncated upstream of the transmembrane domain are not secreted, unless the transforming growth factor beta type II receptor signal sequence is substituted for the endogenous one. This shows that the AMHRII signal sequence is defective and suggests that AMHRII uses its transmembrane domain instead of its signal sequence to translocate to the endoplasmic reticulum, a characteristic of type III membrane proteins.
Increased strength of erythrocyte aggregates in blood of patients with inflammatory bowel disease (2009)

The strength of RBC aggregates is increased in patients with IBD and correlates with the intensity of the acute phase response. This could contribute to bowel damage in these diseases.
Iterative Reweighted Algorithms for Sparse Signal Recovery with Temporally Correlated Source Vectors (2011)

Iterative reweighted algorithms, as a class of algorithms for sparse signal recovery, have been found to have better performance than their non-reweighted counterparts. However, for solving the problem of multiple measurement vectors (MMVs), all the existing reweighted algorithms do not account for temporal correlation among source vectors and thus their performance degrades significantly in the presence of correlation. In this work we propose an iterative reweighted sparse Bayesian learning (SBL) algorithm exploiting the temporal correlation, and motivated by it, we propose a strategy to improve existing reweighted $\ell_2$ algorithms for the MMV problem, i.e. replacing their row norms with Mahalanobis distance measure. Simulations show that the proposed reweighted SBL algorithm has superior performance, and the proposed improvement strategy is effective for existing reweighted $\ell_2$ algorithms.
Data from Integrative Analysis of Cyclin Protein Levels Identifies Cyclin B1 as a Classifier and Predictor of Outcomes in Breast Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; We studied the expression levels of cyclins B1, D1, and E1 and the implications of cyclin overexpression for patient outcomes in distinct breast cancer subtypes defined by clinical variables and transcriptional profiling.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; The expression levels of cyclins B1, D1, and E1 were quantified in 779 breast tumors and 53 cell lines using reverse phase protein arrays and/or transcriptional profiling.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Whereas cyclin E1 overexpression was a specific marker of triple-negative and basal-like tumors, cyclin B1 overexpression occurred in poor prognosis hormone receptor–positive, luminal B and basal-like breast cancers. Cyclin D1 overexpression occurred in luminal and normal-like cancers. Breast cancer subgroups defined by integrated expression of cyclins B1, D1, and E1 correlated significantly (&lt;i&gt;P&lt;/i&gt; &lt; 0.000001) with tumor subtypes defined by transcriptional profiling and clinical criteria. Across three hormone receptor–positive data sets, cyclin B1 was the dominant cyclin associated with poor prognosis in univariate and multivariate analyses. Although &lt;i&gt;CCNE1&lt;/i&gt; was present in significantly higher copy numbers in basal-like versus other subtypes (ANOVA &lt;i&gt;P&lt;/i&gt; &lt; 0.001), &lt;i&gt;CCNB1&lt;/i&gt; gene copy number did not show gain in breast cancer. Instead, cyclin B1 expression was increased in tumors with co-occurrence of &lt;i&gt;TP53&lt;/i&gt; mutations and &lt;i&gt;MYC&lt;/i&gt; amplification, a combination that seems to characterize basal-like and luminal B tumors. &lt;i&gt;CCNB1&lt;/i&gt; gene expression was significantly correlated with &lt;i&gt;PLK, CENPE&lt;/i&gt;, and &lt;i&gt;AURKB&lt;/i&gt; gene expression.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusion:&lt;/b&gt; Cyclins B1, D1, and E1 have distinct expressions in different breast cancer subtypes. Novel &lt;i&gt;PLK, CENPE&lt;/i&gt;, and &lt;i&gt;AURKB&lt;/i&gt; inhibitors should be assessed for therapeutic utility in poor prognosis cyclin B1–overexpressing breast cancers.&lt;/p&gt;&lt;/div&gt;
On the design of linear precoders for orthogonal space-time block codes with limited feedback (2005)

Orthogonal space-time block codes (OSTBC) are among the most practical space-time codes due to their simplicity and optimal decoding. When information about the channel is available at the transmitter, the performance of OSTBC can be significantly improved by exploiting the array gain. However, providing full knowledge of channel state at the transmitter may not he affordable in many practical cases. Thus exploiting partial channel knowledge to improve the performance of OSTBC seems to be attractive. In this work we investigate the design of linear precoders with partial channel knowledge at the transmitter combined with an orthogonal space time code. We derive the condition for optimal precoder subject to a power constraint on the whole transmission block. We also propose a technique for precoder codebook design with limited feedback.
2.5kV-6.5kV Industry Standard IGBT Modules Setting a New Benchmark in SOA Capability (2004)

In this paper, we introduce our new high voltage IGBT HiPak module line-up with voltage ratings ranging from 2.5kV up to 6.5kV. We demonstrate for the first time the performance of our HV-HiPak modules employing ABB’s newly developed high voltage SPT- IGBTs and diodes. The new devices show excellent over all electrical performance and are capable of withstanding extreme conditions during device turn-off and short circuit operation. Therefore, setting new standards in SOA capability for the given voltage class. 1.
Pre-Clinical Evaluation of the Anti-CD22 Immunotoxin CAT-8015 in Combination with Chemotherapy Agents for Childhood B-Precursor Acute Lymphoblastic Leukemia (Pre-B ALL). (2007)

Abstract Despite advances in curative treatment, childhood ALL remains a leading cause of cancer-related mortality in pediatrics and survivors are at risk of multiple late effects. Targeted therapies that overcome chemotherapy resistance and decrease nonspecific toxicities are needed. The B-lineage differentiation antigen CD22 represents a relevant target for pre-B ALL. Monotherapy with the anti-CD22 immunotoxin RFB4(dsFv)-PE38 (CAT-3888 or BL22) has been well tolerated in a pediatric Phase I trial. To date however, only transient clinical activity has been observed with this agent in children with ALL. We conducted cytotoxicity studies to evaluate combination regimens of a higher affinity anti-CD22 immunotoxin (CAT-8015 or HA22) with standard ALL chemotherapeutic agents. Methods: CD22+ human malignant cell samples studied included cell lines of Burkitt lymphoma (CA46) and pre-B ALL (REH and KOPN-8), as well as primary lymphoblasts from 2 children with multiply relapsed pre-B ALL. Flow cytometry was used to determine CD22 expression and anti-CD22 antibody binding using the BD Quantibrite System. Asparaginase, cytarabine, doxorubicin, methotrexate, and vincristine were added to cells individually and in various combinations with CAT-8015. Total incubation time was 2 days for cell lines and 5 days for primary patient blasts. Cell viability was assessed using WST-8. The Chou-Talalay median-effect method was used for data analysis (Chou TC, Talalay P. Adv Enzyme Regul1984;22:27–55). Results: All samples were sensitive to CAT-8015 and to most chemotherapy agents tested. Simultaneous addition of a fixed concentration of CAT-8015 with varying concentrations of each chemotherapy drug led to a 2- to 4-fold reduction in IC50 in comparison to individual agents. Assays with simultaneous addition of equipotency ratios of CAT-8015 and chemotherapy agents had synergistic or additive interactions. These interactions were sequence dependent, and the addition of CAT-8015 followed by chemotherapy led to greater positive interactions than the reverse order. Further assays with simultaneous addition of CAT-8015 and doublet chemotherapy drugs showed enhanced synergistic and additive interactions compared to assays with only doublet agents. Conclusions: CAT-8015 combined with standard chemotherapy agents results in synergistic or additive cytotoxicity against CD22-positive Burkitt lymphoma and pre-B ALL cell lines and primary blasts from children with pre-B ALL. High affinity anti-CD22 recombinant immunotoxins have the potential to overcome chemotherapy resistance and to decrease nonspecific treatment-associated toxicities. In addition, CAT-8015 might synergistically enhance chemotherapy-induced cytotoxicity, thus improving efficacy and allowing the use of less toxic regimens in the future. Clinical trials of recombinant immunotoxins targeting CD22 in combination with standard ALL chemotherapy regimens are planned.
Transversely-Pumped Nonlinear Conversion: Theory and Numerical Results (2000)

A transversely-pumped nonlinear conversion structure is examined. The existing scalar theory is extended to include the vector nature of the electromagnetic fields. Based on these results, detailed simulation of proposed structures is performed.
Utility of Measuring (1,3)-β- d -Glucan in Cerebrospinal Fluid for Diagnosis of Fungal Central Nervous System Infection (2014)

(1-3)-β-d-Glucan (BDG) from cerebrospinal fluid (CSF) is a promising marker for diagnostic and prognostic aid of central nervous system (CNS) fungal infection, but its relationship to serum values has not been studied. Herein, we detected BDG from CSF at levels 2-fold lower than those in serum in patients without evidence of fungal disease but 25-fold higher than those in in serum in noncryptococcal CNS fungal infections. CSF BDG may be a useful biomarker in the evaluation of fungal CNS disease.
Pattern formation and clustering of solitons in nonlinear weakly-correlated wave-systems (2002)

We provide an overview on patter formation in nonlinear, weakly-correlated, wave systems. We show that a weakly-correlated wavefront propagating in a non-instantaneous self-focusing medium undergoes modulation instability and breaks up into stripes and dots forming ordered incoherent structures of quasi-solitons. At higher nonlinearities, these quasi-solitons attract, and form clusters (aggregates) of solitons. Finally, we present very recent results on the first experimental observation of pattern formation and modulation instability in a cavity with incoherent light.
A common mechanism underlies changes of mind about decisions and confidence (2016)

Decisions are accompanied by a degree of confidence that a selected option is correct. A sequential sampling framework explains the speed and accuracy of decisions and extends naturally to the confidence that the decision rendered is likely to be correct. However, discrepancies between confidence and accuracy suggest that confidence might be supported by mechanisms dissociated from the decision process. Here we show that this discrepancy can arise naturally because of simple processing delays. When participants were asked to report choice and confidence simultaneously, their confidence, reaction time and a perceptual decision about motion were explained by bounded evidence accumulation. However, we also observed revisions of the initial choice and/or confidence. These changes of mind were explained by a continuation of the mechanism that led to the initial choice. Our findings extend the sequential sampling framework to vacillation about confidence and invites caution in interpreting dissociations between confidence and accuracy.
Targeting the cross-talk between Urokinase receptor and Formyl peptide receptor type 1 to prevent invasion and trans-endothelial migration of melanoma cells (2017)

Collectively, our findings identify uPAR and FPR1 as relevant effectors of melanoma cell invasiveness and suggest that inhibitors of the uPAR<sub>84-95</sub>/FPR1 cross-talk may be useful for the treatment of metastatic melanoma.