gebhart/patrepeval huggingface dataset:
Suppression of crosstalk in multielectrode arrays with local shielding (2022)

Electrical crosstalk can constrain the performance of multielectrode arrays in electro- and neurophysiology, in terms of both stimulation and recording. This is especially so at high electrode density, desirable for spatiotemporal mapping of bioelectrical signals from multiple cells. Channel interference due to crosstalk is currently only partially addressed, <i>via</i> continuous interleaved sampling or post-data acquisition spike sorting. Here, we show that a locally-shielded electrode architecture significantly suppresses crosstalk, and enables multi-site recording at high electrode density without the need for spike sorting. Arrays of shielded electrodes, prepared by micro- and nanofabrication techniques in a vertically-oriented coaxial geometry, demonstrate at least a 400 times improvement in spatial density over the unshielded case.
Dataset for: Tooling and procedures for hybrid integration of lasers by flip-chip technology (2020)

Dataset to support conference paper : Mitchell, C. et al. (2020). Tooling and procedures for hybrid integration of lasers by flip-chip technology. Paper presented at Electronics System-Integration Technology Conference 2020, Vestfold, Norway.
Real-Time Observation of Platinum Redispersion on Ceria-Based Oxide by In-situ Turbo-XAS in Fluorescence Mode (2007)

A real‐time observation of the redispersion behavior of sintered Pt on ceria‐based oxide was made possible by in‐situ time‐resolved Turbo‐XAS in fluorescence mode. 2 wt% Pt/Ce‐Zr‐Y mixed oxide samples were prepared, and then treated under an aging condition. The average Pt particle size measured by CO absorption method after aging was 7 nm. Redispersion treatments of the previously aged catalyst were carried out at 600°C within an in‐situ XAS cell in a cyclical flow of reducing/oxidizing gases. Pt L3‐edge XANES spectra were collected every 1.1 second under in‐situ conditions. From a change in the XANES spectra, we observed that the Pt particle size of the aged catalyst decreased from 7 to 5 nm after 60 seconds and then to 3 nm after 1000 seconds.
Structural anisotropy and annealing-induced nanoscale atomic rearrangements in metamict titanite (2012)

The structural state of metamict titanite was studied by Raman spectroscopy, complementary high-resolution transmission electron microscopy, and single-crystal X-ray diffraction. The results show that Raman scattering collected from metamict titanite is highly anisotropic, which is typical of single crystals. But surprisingly, the observed Raman-scattering dependence on the sample orientation is much more pronounced for heavily metamict than for weakly metamict titanite samples. These radiation-induced anisotropic effects are related to the specific atomic arrangements in metamict titanite. The Raman spectra collected in backscattering geometry from a plane nearly perpendicular to the chains of corner-sharing TiO6 octahedra arise predominantly from phonon modes in crystalline nanoregions with radiation-induced defects, whereas the contribution of atomic vibrations in radiation-induced amorphous nanoregions is better pronounced in the Raman spectra collected from a plane containing TiO6 chains. This difference provides a unique opportunity to study separately, the structural transformations of the crystalline and amorphous fractions in metamict titanite. The results show that the radiation-induced periodic faults in the crystalline matrix are related to the disturbance of SiO4-TiO6-SiO4-TiO6 rings comprising TiO6 octahedra from different chains, whereas the radiationinduced amorphization is related to the partial change of Ti coordination from octahedral to pyramidal and/or tetrahedral, which in turn violates the Ti-O-Ti intrachain linkages. This indicates that the plane containing Si-O-Ti-O bond rings is less susceptible to a self-accumulation of radiation-induced defects resulting in the development of amorphous regions as compared to the perpendicular plane containing Ti-O bond chains. Sample-orientation-dependent Raman spectroscopy was further applied to annealed metamict titanite to give further insight into the temperature-driven recovery processes in the crystalline and amorphous nanoregions. Multistep annealing by 50 K for 2 h per step gradually suppresses the structural defects in the crystalline fraction as the improvement of the SiO4-TiO6 connectivity within planes nearly perpendicular to the TiO6 chains reaches saturation near 900 K. The annealing-induced recrystallization of the radiation-induced amorphous nanoregions takes place in the temperature range between approximately 650 and 950 K, with a maximum near 750 K. Raman scattering shows that multistep annealing up to 1173 K is insufficient to recover the crystalline structure of the studied metamict titanite sample, which has an accumulated radiation dose of 1.2 × 1018 α-event/g.
Comparison of two methods for location of the ciliary body before glaucoma treatment using High Intensity Focused Ultrasound (HIFU) (2014)

Abstract Purpose To evaluate the ability of the white‐to‐white (WTW) and axial length (AL) measurements to determine the location of the ciliary body before High Intensity Focused Ultrasound (HIFU) glaucoma treatment. Methods 189 eyes (104 phakic, 85 pseudophakic) of 161 patients were included. WTW and AL measurements were measured with the IOLMaster. The HIFU size probe selection was done based using ultrasound biomicroscopy (UBM) and a computer assisted overlay drawing method performed by the manufacturer of the HIFU device. Three probe models with different ring diameters (11, 12 and 13mm) are available for HIFU treatment. Eyes were divided into 3 groups: “11” (n=11), “12” (n=83) and “13” (n=95) corresponding to the size of the probe recommended based on UBM images. The agreement between the group and the WTW and AL were evaluated. Results For groups "11", “12” and “13”, mean WTW and AL measurements were respectively 11.44 ± 0.11 mm and 22.04 ± 0.28 mm, 11.84 ± 0.04 mm and 23.22 ± 0.20 mm, and 12.36 ± 0.06 mm and 25.43 ± 0.3 mm. Mann&amp;Whitney and ANOVA tests showed a significant difference between the 3 groups (p&lt;.05). By placing all the data in a coordinate system WTW‐AL, we can distinguish 3 areas (11, 12 and 13) allowing to choose the diameter with a 93% agreement with the UBM‐based determination. Conclusion It seems possible to determine the probe model with a nomogram based on easily measurable ocular parameters.
International Relations Then and Now: Origins and Trends in Interpretation (2019)

"The new edition of this classic history of International Relations has been completely revised and updated throughout and remains a major guide to the intellectual lineage and development of the field. In International Relations Then and Now the authors examine the historical antecedents and the emergence of theories of the state system during the 18th and 19th Centuries culminating in the short-lived League of Nations. They look at the foundation of International Relations as an academic discipline and the competing theories that emerged within it. In an entirely new part to this volume, they also consider contemporary developments within the theories and methodologies of International Relations, including feminism and postcolonialism. International Relations Then and Now is an indispensable text for students and scholars interested in the history of the development of International Relations"--
Aggregation networks: Cost comparison of WDM ring vs. double star topology (2008)

Due to the increasing demand for higher transmission capacity, originated from upcoming Triple-Play services, network operators are forced to increase the transmission capacity in the backbone and aggregation networks and drive down the costs per bit/s. Many concepts have been presented, optimizing backbone network and increasing the network capacity by introducing higher data rates or channel count. In this paper we focus on aggregation network architectures investigating appropriate architectures for the aggregation of broadband services for an incumbent European network operator. These architectures have to be cost effective and ensure high service availability. These requirements can be met by either aggregating via star topology, using several stages of Ethernet aggregation nodes, by a ring topology using cost effective optical add/drop multiplexers (OADM), or furthermore a mixture of star and ring topologies. The right choice depends on the traffic load, the traffic forecast, distribution of the traffic matrix and underlying fiber graph.
Pharmacological YAP activation promotes regenerative repair of cutaneous wounds (2023)

Chronic cutaneous wounds remain a persistent unmet medical need that decreases life expectancy and quality of life. Here, we report that topical application of PY-60, a small-molecule activator of the transcriptional coactivator Yes-associated protein (YAP), promotes regenerative repair of cutaneous wounds in pig and human models. Pharmacological YAP activation enacts a reversible pro-proliferative transcriptional program in keratinocytes and dermal cells that results in accelerated re-epithelization and regranulation of the wound bed. These results demonstrate that transient topical administration of a YAP activating agent may represent a generalizable therapeutic approach to treating cutaneous wounds.
Modulation of Primary Immune Response by Different Vaccine Adjuvants (2016)

Adjuvants contribute to enhancing and shaping the vaccine immune response through different modes of action. Here early biomarkers of adjuvanticity after primary immunization were investigated using four different adjuvants combined with the chimeric tuberculosis vaccine antigen H56. C57BL/6 mice were immunized by the subcutaneous route with different vaccine formulations, and the modulation of primary CD4<sup>+</sup> T cell and B cell responses was assessed within draining lymph nodes, blood, and spleen, 7 and 12 days after priming. Vaccine formulations containing the liposome system CAF01 or a squalene-based oil-in-water emulsion (o/w squalene), but not aluminum hydroxide (alum) or CpG ODN 1826, elicited a significant primary antigen-specific CD4<sup>+</sup> T cell response compared to antigen alone, 7 days after immunization. The effector function of activated CD4<sup>+</sup> T cells was skewed toward a Th1/Th17 response by CAF01, while a Th1/Th2 response was elicited by o/w squalene. Differentiation of B cells in short-lived plasma cells, and subsequent early H56-specific IgG secretion, was observed in mice immunized with o/w squalene or CpG adjuvants. Tested adjuvants promoted the germinal center reaction with different magnitude. These results show that the immunological activity of different adjuvants can be characterized by profiling early immunization biomarkers after primary immunization. These data and this approach could give an important contribution to the rational development of heterologous prime-boost vaccine immunization protocols.
Evaluating the impact on access of the introduction of nurse-supported care for people with complex rheumatic diseases in British Columbia (2021)

Background A 2010 workforce survey revealed British Columbia was facing a shortage of rheumatologists and a consequent crisis of access to rheumatology care. Rheumatic diseases are chronic, and early intervention is crucial to prevent progression and mitigate systemic damage. Recognizing nurses may be able to perform aspects of rheumatology care and thereby “free up” rheumatologist time, the Ministry of Health introduced billing code G31060 to facilitate nurse-supported consultations for the “complex” rheumatology cases most in need of attention. The objective of this thesis is to evaluate the impact of introducing this new billing code and model of care on access to rheumatology care for the population of BC living with rheumatic disease. Methods I conducted an interrupted time series analysis with a comparator using administrative health data on outpatient visits from Population Data BC. Patients with rheumatic diseases were identified using International Classification of Diseases codes and classified as those who received the intervention (i.e. nurse-supported rheumatologist care) or ‘status quo’ (i.e. rheumatologist care alone). Access was defined as 1) number of unique patients treated per month 2) number of service units billed per month. In sensitivity analyses I explored the impact of more restrictive definitions of intervention which required more “consistent” (at least once in every year) and “high-intensity” (at least 30 per year) billing of G31060. Results The primary cohort included 128,726 patients with rheumatic disease, seen by 29 intervention and 17 comparator rheumatologists. No statistically significant effect change in level or trend of unique patients (pβ6=0.682 &amp; pβ7=0.231) or service units (pβ6=0.744 &amp; pβ7=0.419) attributable to the introduction of G31060 was detected in the primary analysis. Sensitivity analyses revealed statistically significant, increases in patients seen for rheumatologists billing “consistently” (62%) and with “high intensity” (168%) in April 2015 as compared to ‘status quo’. Conclusion The introduction of G31060 does not appear to impact the number of service units billed per month, nor does it necessarily increase the number of patients seen. However, consistent and high-intensity users of G31060 appear to increase the number of unique patients seen per month.
Reduction of the Serum Levels of a Specific Biomarker of Cartilage Degradation (Coll2-1) by Hyaluronic Acid (KARTILAGE® CROSS) Compared to Placebo in Painful Knee Osteoarthritis Patients: the EPIKART Study, a Pilot Prospective Comparative Randomized Double Blind Trial (2017)

NCT02951585 ; clinicaltrial.gov. Retrospectively registered on October 28, 2016.
A Novel Rat Serotonin Receptor: Primary Structure, Pharmacology, and Expression Pattern in Distinct Brain Regions (1993)

Serotonin mediates various central and peripheral functions by its ability to bind to and activate a variety of receptors that belong to four pharmacologically defined classes termed 5-HT1 to 5-HT4. Using a polymerase chain reaction-derived probe, a clone, GPRFO, was isolated from a rat brain cDNA library. This cDNA encodes a putative G protein-coupled receptor that exhibits highest similarity to receptors for biogenic amines. RNA blot analysis indicated that the corresponding gene is expressed in the diencephalon. Consistent with the RNA blot data, GPRFO mRNA has been detected by in situ hybridization in the centrolateral, central medial, and intermediodorsal thalamic nuclei. Highest amounts of GPRFO mRNA, however, have been observed in a small area, i.e., the hippocampal rudiments and the stria longitudinalis. COS-7 cells transiently transfected with the GPRFO cDNA acquire saturable high-affinity binding sites for [3H]serotonin (KD = 41 nM). The pharmacological properties of the receptor differ from those of the known serotonin receptor subtypes, suggesting that the GPRFO cDNA encodes a novel serotonin receptor that is expressed in distinct rat brain regions.
Magnetic End Leakage Flux In A Spoke Type Rotor Permanent Magnet Synchronous Generator (2017)

The spoke type rotor can be used to obtain magnetic<br> flux concentration in permanent magnet machines. This allows the<br> air gap magnetic flux density to exceed the remanent flux density<br> of the permanent magnets but gives problems with leakage fluxes<br> in the magnetic circuit. The end leakage flux of one spoke type<br> permanent magnet rotor design is studied through measurements and<br> finite element simulations. The measurements are performed in the<br> end regions of a 12 kW prototype generator for a vertical axis<br> wind turbine. The simulations are made using three dimensional<br> finite elements to calculate the magnetic field distribution in the<br> end regions of the machine. Also two dimensional finite element<br> simulations are performed and the impact of the two dimensional<br> approximation is studied. It is found that the magnetic leakage flux<br> in the end regions of the machine is equal to about 20% of the flux<br> in the permanent magnets. The overestimation of the performance by<br> the two dimensional approximation is quantified and a curve-fitted<br> expression for its behavior is suggested.
NTIRE 2022 Challenge on Perceptual Image Quality Assessment (2022)

This paper reports on the NTIRE 2022 challenge on perceptual image quality assessment (IQA), held in conjunction with the New Trends in Image Restoration and Enhancement workshop (NTIRE) workshop at CVPR 2022. This challenge is held to address the emerging challenge of IQA by perceptual image processing algorithms. The output images of these algorithms have completely different characteristics from traditional distortions and are included in the PIPAL dataset used in this challenge. This challenge is divided into two tracks, a full-reference IQA track similar to the previous NTIRE IQA challenge and a new track that focuses on the no-reference IQA methods. The challenge has 192 and 179 registered participants for two tracks. In the final testing stage, 7 and 8 participating teams submitted their models and fact sheets. Almost all of them have achieved better results than existing IQA methods, and the winning method can demonstrate state-of-the-art performance.
<title>Optical nonlinearities in diamond</title> (1995)

We have measured n<SUB>2</SUB> and two-photon absorption coefficients in type IIa diamond at (lambda) equals 1064, 532, 355, and 266 nm using Z-scan technique and picosecond pulses from a modelocked Nd:YAG laser. The observed despersion is compared to the two-band theory of semiconductors.
Diode pumped thulium doped fiber laser at 2.29 µm (1989)

Predictions of ultralow losses in fluorozirconate fibers at around 2.5 µm have brought about an interest in rare earth doped fibers for amplification and laser applications in this spectral range. We are investigating laser action directly in these materials and recently reported1 pulsed laser action in a thulium doped ZBLAN fiber at 2.3 µm pumped by an alexandrite laser. We now report for the first time, we believe, lasing in a thulium doped ZBLAN fiber at 2.29µm pumped by a laser diode array. Continuous wave laser emission at 2.7 µm in an erbium doped fluorozirconate fiber pumped by an argon laser has also been reported.2
A Feasibility Study on Wavelet Transform for Reactivity Coefficient Estimation. (2000)

Recently, a new method using Fourier transform has been introduced in place of the conventional method in order to reduce the time required for the measurement of moderator temperature coefficient in domestic PWRs. The basic concept of these methods is to eliminate noise in the reactivity signal. From this point of view, wavelet analysis is also known as an effective method. In this paper, we tried to apply this method to estimate reactivity coefficients of a nuclear reactor. The basic idea of the reactivity coefficient estimation is to analyze the ratios themselves of the corresponding expansion coefficients of the wavelet transform of the signals of reactivity and the relevant parameter. The concept requires no inverse wavelet transform. Based on numerical simulations, it is found that the method can reasonably estimate reactivity coefficient, for example moderator temperature coefficient, with less length of time sequence data than those required for Fourier transform method. We will continue this study to examine the validity of the estimation procedure for the actual reactor data and further to estimate the other reactivity coefficients.
Comprar Dynamic Reconstruction of the Spine | Daniel H. Kim | 9783131426819 | (2007)

Tienda online donde Comprar Dynamic Reconstruction of the Spine al precio 159,55 € de Daniel H. Kim | Frank P. Cammisa | Richard Glenn Fessler, tienda de Libros de Medicina, Libros de Cirugia - Neurocirugia
Automatic generation of entropy coding programs using Flavor (2002)

Flavor (formal language for audio-visual object representation) is a new programming language for media-intensive applications. It extends the typing system of C++ and Java to incorporate bitstream representation semantics. This allows describing in a single place both the in-memory representation of data as well as their bitstream-level (compressed) representation as well. In this paper, we present our approach of hybrid variable length code segmentation in program code generation for parsing entropy-coded data from the bitstream. We also show that this approach produces a very good tradeoff between space (memory required) and time (decoding speed).
VALIDATION OF HPTM-001, A HUMANIZED CANDIDATE THERAPEUTIC ANTIBODY FOR PROMOTING MUCOSAL WOUND HEALING IN IBD (2021)

Abstract A hallmark of the clinical course of patients with Inflammatory Bowel Disease (IBD) is poorly healing erosions and ulcers in the intestinal mucosa. Despite the adverse clinical consequences of non-healing mucosal wounds in IBD, current front-line therapies that selectively target mucosal wound healing are not available. Recent studies revealed an association between colonic inflammation and aberrant glycosylation of epithelial CD44v6. Under conditions of inflammation, epithelial CD44v6 was shown to be decorated with the terminal glycan sialyl Lewis A. Importantly, targeting sialylated Lewis glycans on CD44v6 with a murine antibody GM35 was shown to promote mucosal wound healing in cell lines and in biopsy based wounding assays as well as dextran sodium sulfate (DSS) induced murine colitis models. We sequenced CDRs from GM35 and produced a humanized antibody. Eight candidate human IgG1 clones were produced and screened. hPTM-001.4772 was selected from the eight candidates based on glycan affinity and selectivity compared to GM35. In vitro wound healing studies revealed that PTM-001.4772 was as effective as GM35 in promoting repair of scratch wounds with human intestinal epithelial cells. Furthermore, intraperitoneal injection of mice with hPTM-001.4772 during induction of DSS colitis resulted in reduced weight loss compared to control IgG. These results suggest that hPTM-001.4772 is well-positioned as a unique potential candidate therapeutic for IBD that can be used to selectively promote healing of mucosal wounds and ulcers.
28.4: Electron‐Gun Simulator including Work Function and Cathode Potential Barrier (1998)

Abstract Axi‐asymmetric CRT electron gun simulator which includes the effects of cathode temperature, work function of cathode material and potential barrier near the cathode surface created by an electron beam has been developed. With the simulator, difference of cathode emitter materials, effects of cathode temperature on emission characteristics and transitional phenomena during cathode heating can be evaluated.
Integration of OPC and mask data preparation for reduced data I/O and reduced cycle time (2007)

As process geometries continue to shrink to the 45nm node and beyond, the resulting increases in design complexity and chip pattern density have fueled a data explosion on advanced semiconductor designs. This extends product development cycles and potentially impacts product yield. Two areas in the design flow that are most adversely affected include both mask synthesis (OPC, RET) and Mask Data Preparation. Minimizing data I/O and providing an integrated optical proximity correction (OPC) and mask data preparation solution (MDP), plays an increasingly critical role in reducing the mask synthesis and mask data prep total cycle time. In this paper, an integrated flow of Proteus OPC and CATS MDP are discussed. This integrated flow virtually eliminates the data I/O step between OPC and MDP pre-processing and delivers faster total turn around time by effectively eliminating the time originally spent on MDP pre-processing. The integrated flow and its turn around time performance will be presented.