gebhart/patrepeval huggingface dataset:
Plasminogen activator inhibitor-1 and the kidney (2002)

Plasminogen activator inhibitor-1 (PAI-1) is a serine protease inhibitor that was isolated 20 years ago. First recognized as an inhibitor of intravascular fibrinolysis, it is now evident that PAI-1 is a multifunctional protein with actions that may be dependent on or independent of its protease inhibitory effects. The latter often involve interactions between PAI-1 and vitronectin or the urokinase receptor. The protease-inhibitory actions of PAI-1 extend beyond fibrinolysis and include extracellular matrix turnover and activation of several proenzymes and latent growth factors. PAI-1 has been implicated in several renal pathogenetic processes, including thrombotic microangiopathies and proliferative and/or crescentic glomerulopathies. Most recently, it has become clear that PAI-1 also plays a pivotal role in progressive renal disease, both glomerulosclerosis and tubulointerstitial fibrosis. An active area of present research interest, untold stories are likely to be uncovered soon.
Functional Nmr Imaging Of The Human Brain (2005)

ce Abstracl Knowledge of regional hemodynamics has widespread application for both physiological research and clinical assessment because of the well-established interrelationship between physiological function, energy metabolism, and localized blood supply. External monitoring of the transit of either intravascular or diffusible tracers through the brain has been used for years to measure cerebral hemodynamics. Following bolus administration, the concentration of agent in an area of tissue at a given time is the convolution integral of the input function and the clearance function. Tracer kinetic analysis of these concentration-time data can yield both flow and volume information. In normal brain, lanthanide chelates are confined to the intravascular space by an intact blood-brain barrier. Because cerebral transit times are on the order of seconds, a highspeed imaging technique is needed to resolve the passage of an intravascular agent through the capillary bed. The advent of ultrafast NMR imaging has removed spatial-temporal limitations, allowing for real-time contrast enhanced movies of the transit of contrast agent through the brain. We report our results using the Instascan method (l), which provides a complete 2-D image from a single radio frequency excitation. Preliminary data in selected patients (including stroke, tumor, and neurodegenerative disorders) and normal volunteers are presented.
Hidden risks associated with conventional short intermittent hemodialysis: A call for action to mitigate cardiovascular risk and morbidity (2022)

The development of maintenance hemodialysis (HD) for end stage kidney disease patients is a success story that continues to save many lives. Nevertheless, intermittent renal replacement therapy is also a source of recurrent stress for patients. Conventional thrice weekly short HD is an imperfect treatment that only partially corrects uremic abnormalities, increases cardiovascular risk, and exacerbates disease burden. Altering cycles of fluid loading associated with cardiac stretching (interdialytic phase) and then fluid unloading (intradialytic phase) likely contribute to cardiac and vascular damage. This unphysiologic treatment profile combined with cyclic disturbances including osmotic and electrolytic shifts may contribute to morbidity in dialysis patients and augment the health burden of treatment. As such, HD patients are exposed to multiple stressors including cardiocirculatory, inflammatory, biologic, hypoxemic, and nutritional. This cascade of events can be termed the dialysis stress storm and sickness syndrome. Mitigating cardiovascular risk and morbidity associated with conventional intermittent HD appears to be a priority for improving patient experience and reducing disease burden. In this in-depth review, we summarize the hidden effects of intermittent HD therapy, and call for action to improve delivered HD and develop treatment schedules that are better tolerated and associated with fewer adverse effects.
Inter-HAP Based Geometrical 3-D Channel Model Operating at 28 to 60 GHz for Future 6G Non-Terrestrial Networks (2023)

This paper presents a geometrical 3-D channel model for stationary inter-high altitude platform (HAP) systems operating at millimeter wave (mmWave) frequency bands for the future 6G non-terrestrial networks (NTNs). The motivation of this study is to satisfy such a scenario where a high data rate between two HAPs is desired. In order to do this, the possible reasons for path loss, namely the free space and atmospheric path losses that are severely observed because of the short wavelength of the mmWave signals, are characterized according to 3GPP standards and ITU recommendations. Unlike most of the air-to-air unmanned aerial vehicle (UAV) channel modeling studies where a 2-D channel model is adopted, this study adopts a 3-D approach to characterize the wireless channel between two HAPs to fill the gap in the literature and reflect the actual characteristics of the air-to-air UAV networks. Moreover, this paper introduces the usage of the multiple input multiple output (MIMO) beam-forming technology in the UAV networks to compensate for the path loss effects in mmWave bands. Numerical results show the validation of the proposed 3-D channel model in point-to-point HAP networks at frequencies varying from 28 to 60 GHz.
Size-independent peak efficiency of III-nitride micro-light-emitting-diodes using chemical treatment and sidewall passivation (2019)

Micro-light-emitting-diodes (μLEDs) with size-independent peak external quantum efficiency behavior was demonstrated from 10 × 10 μm2 to 100 × 100 μm2 by employing a combination of chemical treatment and atomic-layer deposition (ALD) sidewall passivation. The chemical treatment and sidewall passivation improved the ideality factors of μLEDs from 3.4 to 2.5. The results from the combination of chemical treatment and ALD sidewall passivation suggest the issue of size dependent efficiency can be resolved with proper sidewall treatments after dry etching.
ChemInform Abstract: Studies on Organosilicon Chemistry. Part 151. Acid‐Catalyzed Cyclization of Vinylsilanes Bearing an Amino Group. Stereoselective Synthesis of Pyrrolidines. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Role of neutrophils in the activation of trypsinogen in severe acute pancreatitis (2011)

The relationship between inflammation and proteolytic activation in pancreatitis is an unresolved issue in pancreatology. The purpose of this study was to define the influence of neutrophils on trypsinogen activation in severe AP. Pancreatitis was induced by infusion of taurocholate into the pancreatic duct in C57BL/6 mice. For neutrophil depletion, an anti-Gr-1 antibody was administered before pancreatitis induction. Administration of the anti-Gr-1 antibody reduced circulating neutrophils by 97%. Pancreatic TAP and serum amylase levels increased 2 h and 24 h after induction of pancreatitis. Neutrophil depletion reduced pancreatic TAP and serum amylase levels at 24 h but not at 2 h after pancreatitis induction. Pancreatic MPO and infiltration of neutrophils, as well as MIP-2 levels, were increased 24 h after taurocholate infusion. Two hours after taurocholate administration, no significant pancreatic infiltration of neutrophils was observed. Injection of the anti-Gr-1 antibody abolished MPO activity, neutrophil accumulation, and MIP-2 levels, as well as acinar cell necrosis, hemorrhage, and edema in the pancreas at 24 h. Moreover, taurocholate-provoked tissue damage and MPO activity in the lung were normalized by neutrophil depletion. Intravital fluorescence microscopy revealed a 97% reduction of leukocytes in the pancreatic microcirculation after administration of the anti-Gr-1 antibody. Our data demonstrate that initial trypsinogen activation is independent of neutrophils, whereas later activation is dependent on neutrophils in the pancreas. Neutrophils are critical in mediating pancreatic and lung tissue damage in severe AP.
Rapid Avr9- and Cf-9-Dependent Activation of MAP Kinases in Tobacco Cell Cultures and Leaves: Convergence of Resistance Gene, Elicitor, Wound, and Salicylate Responses (1999)

Tina Romeis, Pedro Piedras, Shuqun Zhang, Daniel F. Klessig, Heribert Hirt, Jonathan D. G. Jones, Rapid Avr9- and Cf-9-Dependent Activation of MAP Kinases in Tobacco Cell Cultures and Leaves: Convergence of Resistance Gene, Elicitor, Wound, and Salicylate Responses, The Plant Cell, Vol. 11, No. 2 (Feb., 1999), pp. 273-287
Capacitive wireless power transfer circuit and related techniques (2023)

Capacitive wireless power transfer systems are provided. In one embodiment, for example, the system comprises two pair of coupled conducting plates; a first matching network coupled to the first pair of conducting plates; and a second matching network coupled to the second pair of conducting plates. At least one of the first and second matching networks comprises an inductor having inductance value selected based on at least one parasitic capacitance value of the capacitive wireless power transfer system. In another embodiment, a method of designing a capacitive wireless power transfer system is provided comprising determining a parasitic capacitance value of a capacitive wireless power transfer system and determining an inductance value of an inductor of at least one of the first and second matching network having a value selected based on at least one parasitic capacitance value of the capacitive wireless power transfer system.
Locus-specific proteomics identifies new aspects of the chromatin context involved in V region somatic hypermutation (2022)

Abstract Activation-induced cytidine deaminase (AID) somatically hypermutates the immunoglobulin heavy chain variable region (IGHV) gene to create the antibody diversity required to resist infections. This hypermutational process involves many pathways including transcription, DNA structural change and repair. While many of the proteins involved have been identified, their relative abundance, organization and regulation have not been resolved and additional factors and pathways need to be identified. To identify the proteome occupying IGHV, we have utilized dCas9-APEX targeted by guide RNAs to biotinylate and enrich the proteins associated with the mutating V region chromatin in the Ramos human B cell line and compared them to the non-mutating downstream constant region (C) chromatin. We identified hundreds of proteins specifically enriched on the V or C region. We confirmed the functionality of selected factors by examining the changes in the V region-specific proteome after inhibiting transcriptional elongation and somatic mutation with the Dot1L inhibitor EPZ004777. Summary Locus-specific proteomics using dCas9-APEX identifies new aspects of the chromatin context involved in V region somatic hypermutation (SHM) in the human Ramos B cell line. An inhibitor of Dot1L which participates in SHM is used to identify functional SHM-related factors.
Coverage-dependent anisotropy of the NTCDA/Ag(111) interface state dispersion (2019)

We employ density functional theory (DFT) to analyze the dispersion of the electronic state that exists at the commensurate interface between a monolayer of 1,4,5,8-naphthalene-tetracarboxylic acid dianhydride (NTCDA) and the Ag(111) surface. First, we present and verify a hydrogen-termination approach which allows a meaningful DFT description of the interface state with relatively thin silver slabs. Complemented with a projection technique which maps the interface electronic structure onto the original Ag(111) Shockley state, the DFT calculations enable us to analyze the evolution of the dispersion of the NTCDA/Ag(111) interface state when changing of the molecular coverage. Our calculations yield a difference between the interface state energy and the Shockley state energy that scales linearly with coverage. Furthermore, they predict a pronounced anisotropy of the dispersion of the interface state at long wavelengths which also depends linearly on the molecular coverage. The dispersion anisotropy is fully confirmed by our Fourier transform (FT) scanning tunneling spectroscopy (STS) experiments performed on a relaxed phase NTCDA/Ag(111) monolayer. Using feature detection STS (FD-STS), we moreover measure a band gap in the interface state band structure at the Brillouin zone boundary which indicates Bragg scattering of the interface state electrons in the periodic potential of the molecular layer. We thus observe an influence of the molecular layer on the interface state both at long (DFT, STS) and short wavelengths (STS).
Diffusion PSO-LMS Adaptation over Networks (2020)

A hybrid diffusion scheme, PSO-LMS, combining a particle swarm optimization (PSO) strategy and the least-mean square (LMS) algorithm, is developed here to optimize cost functions in a cooperative manner over networks, with a specific focus on channel estimation. The PSO component, through its built-in diffusion process, enhances the proposed scheme’s ability to quickly locate the region containing the global minimum, thus enabling the LMS to take over and exploit both the temporal and spatial diversity of the data so as to quickly hone in on the global minimum. Simulation results illustrate the improved performance of this hybrid scheme over both non-cooperative and other hybrid strategies.
Optical modulator on silicon employing germanium quantum wells (2007)

We demonstrate an electroabsorption modulator on a silicon substrate based on the quantum confined Stark effect in strained germanium quantum wells with silicon-germanium barriers. The peak contrast ratio is 7.3 dB at 1457 nm for a 10 V swing, and exceeds 3 dB from 1441 nm to 1461 nm. The novel side-entry structure employs an asymmetric Fabry-Perot resonator at oblique incidence. Unlike waveguide modulators, the design is insensitive to positional misalignment, maintaining > 3 dB contrast while translating the incident beam 87 mum and 460 mum in orthogonal directions. Since the optical ports are on the substrate edges, the wafer top and bottom are left free for electrical interconnections and thermal management.
D3.1 Selection of metro node architectures and optical technology options (2018)

D3.1 reports details of the Metro Node and Optical Network Elements architectures together with<br> the relevant design guidelines for the access-metro and metro-core edge nodes, as well as the<br> WDM transport systems. The design guidelines and specifications for the technical<br> implementations to be undertaken in WP4 and WP5 are reported, together with a complete outline<br> of the activities undertaken in WP3 during the first year of the METRO-HAUL project.
HMF–glycerol acetals as additives for the debonding of polyurethane adhesives (2020)

Diols prepared <italic>via</italic> acetalisation of HMF with glycerol were incorporated into polyurethanes. This additive enables the selective debonding by acid-catalysed hydrolysis of PU-based adhesives to facilitate the recycling of components at the end of life of the product.
PHOTOREFRACTIVE ZnTe GROWN BY TRAVELLING HEATER METHOD. (2003)

Zinc telluride crystals are grown by the Travelling Heater Method under excess tellurium conditions. Ingots with large single crystals, the order of 1/2 cm3, are obtained. Infrared microscopy shows some tellurium secondary phases. Resistivities of about 1010 Ω.cm are reached using V-Al and V-Sc codopings. A weak photorefractive gain is measured on the ZnTe : V : Al crystal. Samples are characterised by optical spectroscopy, Electron Paramagnetic Resonance and Photoluminescence in order to explain these results. More particularly, the lack of active vanadium is shown to be responsible of the weak gain. A signal corresponding to the Sc interstitial is detected by Photoluminescence.
Evidence of accelerated gastric emptying in longstanding diabetic patients after ingestion of a semisolid meal. (1997)

Recording in the supine position to abolish gravitational influences demonstrated accelerated gastric emptying of a firm semisolid meal with a prevalence of 8%. However, delayed gastric emptying was shown as the predominant gastric manifestation of longstanding insulin-dependent diabetes mellitus with a prevalence of 28%.
Satellite Tracking on the Flyways of Brown-Headed Gulls and Their Potential Role in the Spread of Highly Pathogenic Avian Influenza H5N1 Virus (2012)

Brown-headed gulls (Larus brunnicephalus), winter visitors of Thailand, were tracked by satellite telemetry during 2008-2011 for investigating their roles in the highly pathogenic avian influenza (HPAI) H5N1 virus spread. Eight gulls negative for influenza virus infection were marked with solar-powered satellite platform transmitters at Bang Poo study site in Samut Prakarn province, Thailand; their movements were monitored by the Argos satellite tracking system, and locations were mapped. Five gulls completed their migratory cycles, which spanned 7 countries (China, Bangladesh, India, Myanmar, Thailand, Cambodia, and Vietnam) affected by the HPAI H5N1 virus. Gulls migrated from their breeding grounds in China to stay overwinter in Thailand and Cambodia; while Bangladesh, India, Myanmar, and Vietnam were the places of stopovers during migration. Gulls traveled an average distance of about 2400 km between Thailand and China and spent 1-2 weeks on migration. Although AI surveillance among gulls was conducted at the study site, no AI virus was isolated and no H5N1 viral genome or specific antibody was detected in the 75 gulls tested, but 6.6% of blood samples were positive for pan-influenza A antibody. No AI outbreaks were reported in areas along flyways of gulls in Thailand during the study period. Distance and duration of migration, tolerability of the captive gulls to survive the HPAI H5N1 virus challenge and days at viral shedding after the virus challenging suggested that the Brown-headed gull could be a potential species for AI spread, especially among Southeast Asian countries, the epicenter of H5N1 AI outbreak.
Incidence and sex ratio of transsexualism in Sweden (1996)

The incidence and sex ratio of transsexualism in Sweden were calculated during the period between 1 July 1972 and 30 June 1992 using a case register kept on file at the Swedish Bureau of Social Welfare. Only cases of primary/genuine transsexualism were considered. The study is unique in that it has been performed in exactly the same way as a previous study by one of the authors (JW) in the 1960s and early 1970s. The data can therefore be reliably compared. The results show that the incidence figures remain constant over time and that the incidence of primary/genuine transsexualism is equally common in men and women. A larger group consisting of all those individuals who had applied for sex reassignment revealed a preponderance of men. Analysis showed that this large group included not only primary/genuine transsexuals but also effeminate homosexuals, transvestites and diagnostically uncertain cases. The importance of describing the exact methods used when calculating epidemiological data is highlighted.
Innovative Concepts in Microwave Photonics (2012)

This paper reports the work carried by ITEAM researchers on novel concepts in the field of Microwave Photonics (MWP). It includes activities related to the general modelling of MWP systems, the use of novel multicore fibers and recent advances in the emergent and hot topic of integrated microwave photonics.
Identification of recurrent FGFR3 fusion genes in lung cancer through kinome‐centred RNA sequencing (2013)

Oncogenic fusion genes that involve kinases have proven to be effective targets for therapy in a wide range of cancers. Unfortunately, the diagnostic approaches required to identify these events are struggling to keep pace with the diverse array of genetic alterations that occur in cancer. Diagnostic screening in solid tumours is particularly challenging, as many fusion genes occur with a low frequency. To overcome these limitations, we developed a capture enrichment strategy to enable high-throughput transcript sequencing of the human kinome. This approach provides a global overview of kinase fusion events, irrespective of the identity of the fusion partner. To demonstrate the utility of this system, we profiled 100 non-small cell lung cancers and identified numerous genetic alterations impacting fibroblast growth factor receptor 3 (FGFR3) in lung squamous cell carcinoma and a novel ALK fusion partner in lung adenocarcinoma.
Separable Catalysts in One-Pot Syntheses for Greener Chemistry (2008)

A method that enables the separation between two different catalytic solids used in one-pot reactions is described. Such separation between the two catalytic solids can facilitate their reuse in other catalytic applications and make the synthesis cheap and greener. The method is based on doping one of the catalysts with magnetic nanoparticles, which can make it magnetically separable while the other solid can be separated by filtration. The magnetically separable catalytic solid is designed by a sol–gel process in which a palladium catalyst is encapsulated in a silica sol–gel-modified polyethylenimine composite in the presence of magnetic nanoparticles modified with ionic liquid groups. The other catalytic solid utilized in this study is a solid acid based on cross-linked polystyrene sulfonic acid and can be separated by simple filtration. The two catalytic solids are utilized in one-pot reactions of dehydration/hydrogenation of benzyl alcohols. After reaction, the palladium-based catalyst is separated by applying an external magnetic field and the solid acid is separated by filtration. The magnetically separable palladium-based catalyst is reused after utilization in a one-pot reaction to catalyze three different types of reactions: carbonylation of iodoarenes, Suzuki, and Heck coupling.
A Direct Approach to α‐Trifluoromethylamines. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Design and Hardware Implementation of New Adaptive Fuzzy Logic-Based MPPT Control Method for Photovoltaic Applications (2019)

An adaptive fuzzy logic (FL)-based new maximum power point (MPP) tracking (MPPT) methodology for controlling photovoltaic (PV) systems is proposed, designed, and implemented in this paper. The existing methods for implementing FL-based MPPTs lack for adaptivity with the operating point, which varies in wide range in practical PV systems with operating irradiance and ambient temperature. The new proposed adaptive FL-based MPPT (AFL-MPPT) algorithm is simple, accurate, and provides faster convergence to optimal operating point. The effectiveness and feasibility verifications of the proposed AFL-MPPT methodology are validated with considering various operating conditions at slow and fast change of solar radiation. In addition, the simplified implementation of the proposed algorithm is carried out using C-block in PSIM software environment, wherein the proposed algorithm and system are simulated. Additionally, experimental results are performed using a floating-point digital signal processing (DSP) controller (TMS320F28335) for verifying the feasibility of the proposed AFL-MPPT methodology. The results of simulations and experimental prototypes show great consistency and prove the capability of the new AFL-MPPT methodology to extract MPPT rapidly and precisely. The new proposed AFL-MPPT method achieves accurate output power of the PV system with smooth and low ripple. In addition, the new proposed AFL-MPPT method benefits fast dynamics and it reaches steady state within 0.01 s.