gebhart/patrepeval huggingface dataset:
Toward In-Network Event Detection and Filtering for Publish/Subscribe Communication Using Programmable Data Planes (2020)

Industrial Internet of Things (I-IoT) applications require a large number of sensor data to be processed under tight delay and jitter constraints. In such applications, flexible event detection and fast reaction to critical events is an important building block. Traditional approaches use either proprietary networks and dedicated hardware or transmit sensor data towards processing elements in the Cloud or at the Network Edge, using distributed stream processing frameworks. For scalability, a large number of servers are needed and processing on commodity CPUs typically involves high and unpredictable latency. In this article, we explore how programmable data planes can be used to detect events flexibly and trigger customized and programmable actions directly from the switch program or the programmable network interface card (SmartNIC). We present FastReact-PS, an event-based publish/subscribe I-IoT processing framework in P4 language, which can be flexibly customized from the control plane. Together with stateful processing, FastReact-PS supports windowed time series analysis as well as complex event detection and processing based on Boolean logic directly in the data plane of newly emerging programmable networking devices. The logic can be adjusted dynamically from the control plane without the need for recompilation. We implement FastReact-PS in P4 and evaluate it on both a SmartNIC and a DPDK-based software switch running in user space. Our evaluation shows that the latency is reduced by one order of magnitude compared to end-host based approaches at significantly lower jitter while being scalable to processing up to 11 million events per second.
Holding current and switch-on mechanisms in 12 kV, 100 A 4H-SiC optically triggered thyristors (2012)

Temperature dependence of the holding current has been studied in high-voltage (12 kV class) 4H-SiC optically triggered thyristors in the temperature range from 300 to 425 K. The holding current Ih monotonically decreases with increasing temperature T due to two factors: enhanced thermal ionization of comparatively deep Al acceptors in the p+ emitter and increasing carrier lifetime in the blocking p base. The Ih(T) dependence reveals the existence of a 'weak point' within the optical window, which is characterized by a substantially smaller critical charge than that within the remaining part of the window. Analysis of the Ih(T) dependence confirms that high-voltage SiC thyristors are switched-on at room temperature only at a high injection level in the blocking base. At elevated temperatures, the same thyristor is switched on by the 'classical' mechanism typical of Si thyristors. Effective shunting of the p++–n emitter junction affects the properties of the thyristor. Possible effective-shunting mechanisms are discussed.
Thioesterase-mediated side chain transesterification generates potent Gq signaling inhibitor FR900359 (2021)

The potent and selective Gq protein inhibitor depsipeptide FR900359 (FR), originally discovered as the product of an uncultivable plant endosymbiont, is synthesized by a complex biosynthetic system comprising two nonribosomal peptide synthetase (NRPS) assembly lines. Here we characterize a cultivable bacterial FR producer, enabling detailed investigations into biosynthesis and attachment of the functionally important FR side chain. We reconstitute side chain assembly by the monomodular NRPS FrsA and the non-heme monooxygenase FrsH, and characterize intermolecular side chain transesterification to the final macrocyclic intermediate FR-Core, mediated by the FrsA thioesterase domain. We harness FrsA substrate promiscuity to generate FR analogs with altered side chains and demonstrate indispensability of the FR side chain for efficient Gq inhibition by comparative bioactivity, toxicity and docking studies. Finally, evolution of FR and side chain biosynthesis is discussed based on bioinformatics analyses. Side chain transesterification boosts potency and target affinity of selective Gq inhibitor natural products.
Data from Loss of miR125a Expression in a Model of K-ras–Dependent Pulmonary Premalignancy (2023)

&lt;div&gt;Abstract&lt;p&gt;Understanding the molecular pathogenesis of lung cancer is necessary to identify biomarkers/targets specific to individual airway molecular profiles and to identify options for targeted chemoprevention. Herein, we identify mechanisms by which loss of microRNA (miRNA)125a-3p (miR125a) contributes to the malignant potential of human bronchial epithelial cells (HBEC) harboring an activating point mutation of the K-ras proto-oncogene (HBEC K-ras). Among other miRNAs, we identified significant miR125a loss in HBEC K-ras lines and determined that miR125a is regulated by the PEA3 transcription factor. PEA3 is upregulated in HBEC K-ras cells, and genetic knockdown of PEA3 restores miR125a expression. From a panel of inflammatory/angiogenic factors, we identified increased CXCL1 and vascular endothelial growth factor (VEGF) production by HBEC K-ras cells and determined that miR125a overexpression significantly reduces K-ras–mediated production of these tumorigenic factors. miR125a overexpression also abrogates increased proliferation of HBEC K-ras cells and suppresses anchorage-independent growth (AIG) of HBEC K-ras/P53 cells, the latter of which is CXCL1-dependent. Finally, pioglitazone increases levels of miR125a in HBEC K-ras cells via PEA3 downregulation. In addition, pioglitazone and miR125a overexpression elicit similar phenotypic responses, including suppression of both proliferation and VEGF production. Our findings implicate miR125a loss in lung carcinogenesis and lay the groundwork for future studies to determine whether miR125a is a possible biomarker for lung carcinogenesis and/or a chemoprevention target. Moreover, our studies illustrate that pharmacologic augmentation of miR125a in K-ras–mutated pulmonary epithelium effectively abrogates several deleterious downstream events associated with the mutation. &lt;i&gt;Cancer Prev Res; 7(8); 845–55. ©2014 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Abstract B04: A chemical genetic screen identifies novel ATM/ATR pathway inhibitors that sensitize p53-deficient cells to DNA-damaging agents without affecting ATR kinase catalytic activity (2013)

Abstract An important goal in cancer therapy has been to selectively sensitize cancers to existing drugs that typically work by inducing DNA damage. In particular, many cancers are p53-defective and chemoresistant, thus novel approaches to target p53-defective cancers are needed. One promising strategy to sensitize p53-deficient cells has been to inhibit DNA damage response kinases such as ATM/ATR via ATP-competitive kinase inhibitors. To better understand ATM/ATR activation mechanisms and discover novel probes for the ATM/ATR pathway, we performed a phenotype-based screen of 9,195 small-molecule compounds for inhibitors of hydroxyurea-induced phosphorylation of Chk1, a key ATR substrate. After subsequent biological screens, we selected 4 compounds that inhibited ATR and ATM pathways; 3 were known bioactive agents and 1 was a diversity-oriented-synthetic product. These compounds sensitized p53-deficient cells to diverse DNA-damaging agents. Xenograft experiments were performed on one compound, and it showed synergistic suppression of p53-deficient tumor growth with cisplatin. Importantly, these compounds did not suppress ATR kinase catalytic activity in vitro, unlike typical ATM/ATR kinase inhibitors that are ATP-competitive. To identify molecular targets of one compound, “MARPIN” (ATM and ATR pathway inhibitor), we defined its active site through structure-activity relationship analysis, resulting in synthesis of inactive derivatives of MARPIN. Identification of proteins that specifically bind MARPIN, but not its inactive derivatives, is underway. This phenotype-based chemical genetic screen identified novel ATM/ATR pathway inhibitors that are mechanistically distinct from kinase catalytic inhibitors, and these compounds could serve as probes to identify previously unrecognized druggable targets in DNA damage response pathways. Citation Format: Masaoki Kawasumi, James E. Bradner, Nicola Tolliday, Renee Thibodeau, Heather Sloan, Kay M. Brummond, Paul Nghiem. A chemical genetic screen identifies novel ATM/ATR pathway inhibitors that sensitize p53-deficient cells to DNA-damaging agents without affecting ATR kinase catalytic activity. [abstract]. In: Proceedings of the AACR Precision Medicine Series: Synthetic Lethal Approaches to Cancer Vulnerabilities; May 17-20, 2013; Bellevue, WA. Philadelphia (PA): AACR; Mol Cancer Ther 2013;12(5 Suppl):Abstract nr B04.
Distinct cellular dynamics associated with response to CAR-T therapy for refractory B-cell lymphoma (2022)

Abstract Chimeric Antigen Receptor (CAR)-T cell therapy has revolutionized the treatment of hematologic malignancies. Approximately half of patients with refractory large B-cell lymphomas achieve durable responses from CD19-targeting CAR-T treatment; however, failure mechanisms are identified in only a fraction of cases. To gain novel insights into the basis of clinical response, we performed single-cell transcriptome sequencing of 105 pre- and post-treatment peripheral blood mononuclear cell samples, and infusion products collected from 32 individuals with high-grade B cell lymphoma treated with either of two CD19 CAR-T products: axicabtagene ciloleucel (axi-cel) or tisagenlecleucel (tisa-cel). Expansion of proliferative memory-like CD8 clones was a hallmark of tisa-cel response, whereas axi-cel responders displayed more heterogeneous populations. Elevations in CAR-T regulatory cells (CAR-Tregs) among non-responders to axi-cel were detected, and these populations were capable of suppressing conventional CAR-T cell expansion and driving late relapses in an in vivo model. Our analyses reveal the temporal dynamics of effective responses to CAR-T therapy, the distinct molecular phenotypes of CAR-T cells with differing designs, and the capacity for even small increases in CAR-Tregs to drive relapse.
Effect of Renal Function Impairment on the Pharmacokinetics, Safety, and Tolerability of the Iminosugar Sinbaglustat (2020)

Sinbaglustat (ACT-519276), a brain-penetrating inhibitor of glucosylceramide synthase and nonlysosomal glucosylceramidase, is developed as a new therapy for lysosomal storage disorders. In the first-in-human study, sinbaglustat was primarily excreted unchanged in urine. This study was conducted to evaluate the effect of mild, moderate, and severe renal function impairment on the safety, tolerability, and pharmacokinetics (PK) of sinbaglustat. In this single-center, open-label study, 32 subjects (8 per renal function group, assessed by the Cockcroft-Gault formula, and 8 healthy subjects) received a single oral dose of 200 mg sinbaglustat. Plasma PK parameters of sinbaglustat were derived by noncompartmental analysis. Standard safety and tolerability evaluations were analyzed descriptively. When compared with healthy subjects, C<sub>max</sub> did not present clinically relevant differences in subjects with impaired renal function, but median t<sub>max</sub> was slightly longer in subjects with moderate and severe renal function impairment. Overall, when compared with healthy subjects, exposure to sinbaglustat based on AUC<sub>0-t</sub> (geometric mean and 90% confidence interval) increased in subjects with mild, moderate, and severe renal function impairment by 1.2-fold (1.08- to 1.36-fold), 1.8-fold (1.47- to 2.17-fold), and 2.6-fold (2.23- to 3.00-fold), respectively. There were no clinically relevant findings on electrocardiogram, vital signs, and clinical laboratory variables. Headache was reported by 2 of 24 subjects with renal function impairment and by 2 of 8 healthy subjects. In conclusion, 200 mg of sinbaglustat was well tolerated in all groups. In future studies, a 2- and 3-fold dose reduction is needed for subjects with moderate and severe renal function impairment, respectively.
Epitaxial PZT FILMS deposited by pulsed laser deposition for MEMS application (2006)

Pb(Zr0.52Ti0.48)O3 (PZT) thin films were in situ deposited by pulsed laser deposition (PLD) on Pt/Ti/SiO2/Si substrates using a template layer derived by sol-gel method. A 0.1-µm-thick PZT layer with (111) or (100)-preferred orientation was first deposited onto Pt/Ti/SiO2/Si substrates using the sol-gel method, and than a PZT layer with thickness of 1µm was in situ deposited by PLD on the above-mentioned PZT layer. The crystalline phases and the preferred orientations of the PZT films were investigated by X-ray diffraction analysis. Surface and cross-sectional morphologies were observed by scanning electron microscopy and transmission electron microscopy. The electrical properties of the films were evaluated by measuring their P-E hysteresis loops and dielectric constants. The preferred orientation of the films can be controlled using the template layer derived by the sol-gel method. The deposition temperature required to obtain the perovskite phase in this process is approximately 460°C, and is significantly lower than that in the case of direct film deposition by PLD on the Pt/Ti/SiO2/Si substrates. Keywords : lead zirconate titanate (PZT), thin film, sol-gel method, laser ablation, electrical properties
The Effect of Low-Molecular-Weight Poly(ethylene glycol) (PEG) Plasticizers on the Transport Properties of Lithium Fluorosulfonimide Ionic Melt Electrolytes (2014)

The influence of low-molecular-weight poly(ethylene glycol) (PEG, Mw ≈ 550 Da) plasticizers on the rheology and ion-transport properties of fluorosulfonimide-based polyether ionic melt (IM) electrolytes has been investigated experimentally and via molecular dynamics (MD) simulations. Addition of PEG plasticizer to samples of IM electrolytes caused a decrease in electrolyte viscosity coupled to an increase in ionic conductivity. MD simulations revealed that addition of plasticizer increased self-diffusion coefficients for both cations and anions with the plasticizer being the fastest diffusing species. Application of a VTF model to fit variable-temperature conductivity and fluidity data shows that plasticization decreases the apparent activation energy (Ea) and pre-exponential factor A for ion transport and also for viscous flow. Increased ionic conductivity with plasticization is thought to reflect a combination of factors including lower viscosity and faster polyether chain segmental dynamics in the electrolyte, coupled with a change in the ion transport mechanism to favor ion solvation and transport by polyethers derived from the plasticizer. Current interrupt experiments with Li/electrolyte/Li cells revealed evidence for salt concentration polarization in electrolytes containing large amounts of plasticizer but not in electrolytes without added plasticizer.
Iodine-125 metaraminol: A new platelet specific labeling agent (1984)

Two nitrofuran compounds, nifurtimox and nitrofurantoin, inhibited in a concentration-dependent manner the NADPH-, iron-induced lipid peroxidation in rat liver microsomes, as shown by the decreased rate of MDA accumulation. Other nitro compounds (benznidazole and chloramphenicol) were relatively inactive. Nifurtimox inhibition affected polyenoic fatty acids and cytochrome P-450 degradation that follows lipid peroxidation. The ascorbate- or tert-butyl hydroperoxide-dependent lipid peroxidations were much less inhibited than the NADPH-dependent one. Nifurtimox and nitrofurantoin, but not benznidazole and chloramphenicol, strongly stimulated the microsomal NADPH-oxidase activity, thus supporting electron diversion, as the main cause of the inhibition of peroxidation initiation.
Optimization of the current distribution in press-pack high power IGBT modules (2010)

Today's IGBT modules achieve high current ratings by paralleling several semiconductor switches. For high power and high voltage applications, the press-pack IGBT design is a technology of increasing importance, since it is designed for a low inductance series connection in a module stack. This work examines the module-internal current distribution in a press-pack configuration during switching transients by means of the PEEC simulation method. Parasitic effects which result in current unbalances between the paralleled switches are determined and quantified, where special emphasis is put on the power module external interconnection wiring and its influence on the current distribution and power loss in the distinct switches. A hardware test setup is discussed in detail, and a layout design optimization is which balances the loss distribution among the switches.
Mechanical Comparison of Biplanar Proximal Closing Wedge Osteotomy with Plantar Plate Fixation Versus Crescentic Osteotomy with Screw Fixation for the Correction of Metatarsus Primus Varus (1998)

Proximal crescentic metatarsal osteotomy is a clinically successful technique for correcting metatarsus primus varus in hallux valgus surgery. However, there have been instances of dorsal elevation of the metatarsal head with this technique. Mechanical testing on 10 matched pairs of cadaver feet was performed to evaluate a new technique combining a biplanar closing wedge osteotomy and plantar plate fixation versus crescentic metatarsal osteotomy. The specimens were tested in cantilever-bending mode on an MTS Mini Bionix test frame. The mean load-to-failure values were 127.2 +/- 81.9 N (SD) for biplanar osteotomy with plate fixation and 44.9 +/- 43.3 N for crescentic osteotomy (P = 0.019); the mean stiffness values at the initial portion of the load-deflection curve were 83.11 +/- 73.76 N/mm and 31.95 +/- 43.00 N/mm, respectively (P = 0.012). The biplanar wedge osteotomy with plantar plate fixation demonstrated significantly stronger fixation than the crescentic osteotomy, with higher mean load-to-failure and stiffness values. This newly described technique may provide an acceptable alternative for patients at risk for dorsal elevation of the metatarsal, particularly those who are noncompliant or have osteopenia. Clinical study will determine whether this new technique offers satisfactory long-term results.
Hyperspectral cell sociology reveals spatial tumor-immune cell interactions associated with lung cancer recurrence (2019)

Hyperspectral Cell Sociology expands our understanding of the complex interplay between tumor cells and immune infiltrate. This technology could improve predictions of responses to immunotherapy and lead to a deeper understanding of anti-tumor immunity.
Localization of MYOC transcripts in human eye and optic nerve by in situ hybridization. (2000)

MYOC gene expression in the trabecular meshwork, Schlemm's canal, scleral spur, and ciliary muscle indicates a structural or functional role for myocilin in the regulation of aqueous humor outflow that may influence intraocular pressure. MYOC expression in the optic nerve suggests that changes in the structural, metabolic, or neurotropic support of the optic nerve may influence its susceptibility to glaucomatous damage.
Refinements in membrane projection lithography: a route to fabrication of 3D metamaterials. (2020)

Abstract not provided.
The centre of rotation of the shoulder complex and the effect of normalisation (2016)

Shoulder motions consist of a composite movement of three joints and one pseudo-joint, which together dictate the humerothoracic motion. The purpose of this work was to quantify the location of the centre of rotation (CoR) of the shoulder complex as a whole. Dynamic motion of 12 participants was recorded using optical motion tracking during coronal, scapular and sagittal plane elevation. The instantaneous CoR was found for each angle of elevation using helical axes projected onto the three planes of motion. The location of an average CoR for each plane was evaluated using digitised and anthropometric measures for normalisation. When conducting motion in the coronal, scapular, and sagittal planes, respectively, the coefficients for locating the CoRs of the shoulder complex are −61%, −61%, and −65% of the anterior–posterior dimension – the vector between the midpoint of the incisura jugularis and the xiphoid process and the midpoint of the seventh cervical vertebra and the eighth thoracic vertebra; 0%, −1%, and −2% of the superior–inferior dimension – the vector between the midpoint of the acromioclavicular joints and the midpoint of the anterior superior iliac spines; and 57%, 57%, and 78% of the medial–lateral dimension −0.129 times the height of the participant. Knowing the location of the CoR of the shoulder complex as a whole enables improved participant positioning for evaluation and rehabilitation activities that involve movement of the hand with a fixed radius, such as those that employ isokinetic dynamometers.
Multi-trigger resist for electron beam and extreme ultraviolet lithography (2018)

The multi-trigger resist (MTR) is a new negative tone molecular resist platform for electron beam lithography, as well as extreme ultraviolet and optical lithography. The performance of xMT resist, the precursor to MTR resist, which shows a good combination of sensitivity, low line edge roughness and high-resolution patterning has previously been reported. The results obtained so far as the behaviour of the resist is driven towards the multi-trigger regime by manipulating the resist formulation are presented. A feature size of 13 nm in semi-dense (1:1.5 line/space) patterns, and 22nm diameter pillar patterns are demonstrated in electron beam, and 16 nm half-pitch resolution patterns are demonstrated in (extreme ultraviolet) EUV. An improvement in the LER value is seen in the higher MTR formulations.
Heat-Flow-Type Warmth Sensor with Sub-Second Response for Material Discrimination (2021)

This paper presents a heat-flow-type warmth sensor with sub-second response that discriminates materials for tactile sensing of robots. In previous study, the original sensor structure was proposed, and the material discrimination using a heat-flow peak in the heat-flow transitional phenomenon was demonstrated. In this study, to realize the material discrimination function as high response as human, the heat-flow-type warmth sensor with sub-second response was developed. Firstly, a thermal equivalent circuit of the sensor was proposed to simulate the transitional heat-flow characteristics. The simulation results showed that the response time of heat-flow peak is improved by reducing a heat capacity of the sensor and a thermal resistance of a surface material in the sensor. Secondly, miniaturized heat-flow-type warmth sensors downsized to 1/3.4 of previous one were fabricated according to the simulation results. The three miniaturized sensors were fabricated using three surface materials with different thermal resistances, and the experimental characteristics were compared to the simulation results. The tendencies of the experimental characteristics were agreement with those of the simulation results. Finally, the experimental results demonstrated the heat-flow-peak response times of 0.2 s with sufficient material discrimination function. Compared to the previous warmth sensor, the response time was improved 28 times.
Guided full-arch immediate-function treatment modality for the edentulous and terminal dentition patient. (2015)

This article reviews the rationale, techniques, and advantages of a guided full-arch immediatefunction implant treatment modality that includes placement of a prefabricated, bar-supported, monolithic polymethyl methacrylate acrylic (PMMA) prosthesis for edentulous and terminal dentition patients. A case presentation depicting the protocol shows it to be an effective and predictable approach to providing fullarch immediate fixed teeth, particularly when compared to conventional denture conversion techniques.