gebhart/patrepeval huggingface dataset:
A continuous multicolumn countercurrent solvent gradient purification (MCSGP) process (2007)

Biomolecules are often purified via solvent gradient batch chromatography. Typically suitable smooth linear solvent gradients are applied to obtain the separation between the desired component and hundreds of impurities. The desired product is usually intermediate between weakly and strongly adsorbing impurities, and therefore a central cut is required to get the desired pure product. The stationary phases used for preparative and industrial separations have a low efficiency due to strong axial dispersion and strong mass transfer resistances. Therefore a satisfactory purification often cannot be achieved in a single chromatographic step. For large scale productions and for very valuable molecules, countercurrent operation such as the well known SMB process, is needed in order to increase separation efficiency, yield and productivity. In this work a novel multicolumn solvent gradient purification process (MCSGP-process) is introduced, which combines two chromatographic separation techniques, which are solvent gradient batch and continuous countercurrent SMB. The process consists of several chromatographic columns, which are switched in position opposite to the flow direction. Most of the columns are equipped with a gradient pump to adjust the modifier concentration at the column inlet. Some columns are interconnected, so that non pure product streams are internally, countercurrently recycled. Other columns are short circuited and operate in batch mode. As a working example the purification of an industrial stream containing 46% of the hormone Calcitonin is considered. It is found that for the required purity the MCSGP unit achieves a yield close to 100% compared to a maximum value of a single column batch chromatography of 66%.
Controlling the Role of Nanopore Morphology in Capillary Condensation (2012)

The effect of pore morphology on capillary condensation and evaporation in nanoporous silicon is studied experimentally. A variety of cooperative and local effects are observed in tailored nanopores with well-defined regions by directly probing gas adsorption in each region using optical interferometry. All observations are ascribed to the ability of the nanopore region to access the gas reservoir directly and the nucleation of liquid bridges at local heterogeneities within the nanopore region. These assumptions, consistent with recent simulations, can be extended to any real nanoporous system.
Immunotoxicological Characteristics of Sodium Methyldithiocarbamate (1992)

This study was conducted to assess immunotoxicological effects and selected general toxicological effects of sodium methyldithiocarbamate (SMD). Initially, the compound was administered orally to female B6C3F1 mice at 300 mg/kg/day for 3, 5, 10, or 14 days. Body, liver, kidney, spleen, and thymus weights were measured. Selected hematological and bone marrow parameters were examined. Flow cytometric analysis was used to assess changes in lymphocyte subpopulations in the thyrnus and spleen, and production of antibody-forming cells in vitro was measured. Major effects included decreased thymus weight at all time points; increased spleen weight after 10 or 14 days of exposure, increased bone marrow cellularity after 10 or 14 days of exposure, significant decreases in mature lymphocyte subpopulations which were greater in the thymus than in the spleen, relatively selective depletion of the major subpopulation of thy mocytes (CD4+CD8+ and decreased body weight. Overall patterns of changes were consistent with the conclusion that SMD rapidly depletes most CD4+CD8+ thymocytes, more slowly depletes a smaller number of mature lymphocytes in the thymus and spleen, and induces compensatory and/or detoxication mechanisms after 10–14 days of exposure. Subsequent experiments were done to assess selected immune function parameters. SMD at 50–300 mg/kg/day for 7 days caused substantial, dose-dependent suppression of NK cell activity. No suppression of antibody production in vivo or splenocyte responses to mitogens or allogeneic lymphocytes in vitro was detected. NK cell activity, thymus weight, and CD4+CD8+ thymocyte numbers were suppressed by dermal administration of SMD. These results indicate that NK cell activity is significantly decreased by SMD, but mature T and B lymphocytes which survive treatment are generally not significantly impaired with regard to the functions tested. In several experiments, immunological parameters were significantly suppressed in the absence of a significant decrease in body weight, suggesting that most of the effects of SMD on the immune system are not secondary to generalized toxicity.
HEMATOPOIETIC STEM CELL TRANSPLANT IN AGGRESSIVE T AND NK/T CELL LYMPHOMA - ROLE OF UPFRONT AUTOLOGOUS TRANSPLANT IN NODAL PERIPHERAL T-CELL LYMPHOMA (2021)

Aggressive T and NK/T-cell lymphoma are known to have a high risk of relapse and poor long-term prognosis. Hematopoietic stem cell transplantation has been performed as part of consolidation or salvage treatment. We retrospectively studied the outcomes of autologous (A) and allogeneic (allo) hematopoietic stem cell transplantation (SCT) in aggressive T and NK/T-cell lymphoma at our center between 2010 to 2020. Patients with nodal peripheral T-cell lymphoma (PTCL) that were younger than 65 years old who did not receive upfront autologous SCT (ASCT) at first complete remission were selected from our registry data for further comparison. Thirty-six patients underwent ASCT, and 16 patients underwent alloSCT. In the ASCT cohort, 18 patients with nodal PTCL who underwent upfront ASCT at first complete remission (upfront ASCT) were compared with 15 patients with nodal PTCL who were in first complete remission after single-line induction but did not receive ASCT. The two-year progression-free survival (PFS) and overall survival (OS) rates for the ASCT cohort were 58% and 73%, respectively. The two-year PFS and OS for the alloSCT cohort were 47% (<i>P</i>=0.35, <i>P</i>=0.02, respectively). Twenty-four patients who received SCT at first remission (21 ASCT and three alloSCT) had a two-year PFS and OS of 75% and 89%, respectively. In comparison, 28 patients who received SCT at relapse/refractory (15 ASCT and 13 alloSCT) had a two-year PFS and OS of 40% and 50%, respectively (<i>P</i>=0.047, <i>P</i>=0.024, respectively). Patients in complete remission prior to transplantation (n=42) had a two-year PFS and OS of 59% and 73%, respectively. In contrast, patients in partial remission prior to transplantation (n=10) had a two-year PFS and OS of 40% and 48%, respectively (p>0.05). Non-relapse mortality occurred in 6% and 43% of ASCT and AlloSCT, respectively. Multivariate analysis revealed that EBV-positivity at diagnosis indicated poorer PFS. EBV-positivity at diagnosis and more than two prior lines of treatment at transplant were associated with poorer OS. For nodal PTCL, the two-year PFS and OS were 79% and 100% for the upfront ASCT cohort and 78% and 92% for the non-upfront ASCT cohort, respectively (p>0.05). Hematopoietic SCT is a feasible treatment option for aggressive T and NK/T-cell lymphoma. Patients who underwent SCT at first remission had better survival rates than those who underwent SCT at relapse/refractory. Nevertheless, due to the limited sample size of the current study, the role of upfront ASCT in patients with nodal PTCL who achieved first complete remission remains unclear.
Mode-Multiplexed Transmission Over a 209-km DGD-Compensated Hybrid Few-Mode Fiber Span (2012)

We transmitted five wavelength channels and six spatial and polarization modes over a 209-km-long hybrid few-mode fiber span. The fiber supports six spatial and polarization modes, and consists of a first section of large effective area depressed-cladding few-mode fiber followed by a graded-index few-mode fiber. The differential group delay is compensated by using fiber spools with differential group delay of opposite sign. Low-loss three-spot mode couplers are used to couple to the few-mode fiber, and backward pumped-distributed Raman amplification is used to overcome the fiber loss. The 40-Gb/s QPSK signals with an aggregate capacity of 1.2 Tb/s are recovered by coherent multiple-input–multiple-output off-line digital signal processing. The impulse response at various span lengths is compared and analyzed in detail.
Inhibition of PDGF receptor signaling in tumor stroma : Effects on interstitial hypertension, drug uptake and therapeutic response (2002)

The role of platelet-derived growth factor (PDGF) in malignancies involves both autocrine and paracrine stimulation of cells within the tumor. The interstitial fluid pressure (IFP) is one of the forces that govern the transvascular flow of fluids. In both experimental and clinical cancers, the IFP is elevated and is thought to act as a barrier for delivery of drugs. Increasing evidence points to PDGF as a positive regulator of the interstitial fluid pressure in loose connective tissue. In this thesis, the effect of PDGF receptor inhibition on the tumor IFP, transvascular transport and efficacy of anti-cancer drugs is investigated. All studies were performed using tumor models that display extensive tumor stroma and PDGF receptor expression restricted to stroma cells. Blocking of PDGF receptor signaling significantly reduced the tumor IFP in various tumor models. In parallel, pre-treatment with PDGF antagonists increased the tumor content of cytotoxic agents without affecting the uptake in other organs. Moreover, combination treatment with PDGF receptor inhibitors and chemotherapeutic agents dramatically enhanced the anti-tumor effects of the cytotoxic drugs, whereas treatment with only PDGF receptor inhibitors did not affect the growth of the tumors. Beneficial effects on the tumor reponse to radioimmunotherapy were also produced after concomitant administration of PDGF antagonists. Importantly, anti-angiogenic effects, changes in cell composition and increased tumor cell sensitivity to cytotoxic agents were ruled out as the cause for the synergistic effects. Studies with different temporal scheduling of PDGF receptor inhibitors demonstrated a perfect correlation between a reduced IFP, an increased transvascular transport and an enhanced therapeutic effect of cytotoxic drugs, strongly suggesting that the phenomena are causally linked. The studies presented herein illustrate for the first time the potential of cells in the stroma compartment as a target for efforts to treat cancer. In conclusion, a novel, possibly general, strategy to enhance the effects of conventional anti-cancer drugs has been identified.
Microfluidics: Guidance and Self‐Sorting of Active Swimmers: 3D Periodic Arrays Increase Persistence Length of Human Sperm Selecting for the Fittest (Adv. Sci. 2/2018) (2018)

A model-driven design featuring pillar arrays that efficiently and non-invasively isolate highly motile and morphological normal sperm, with normal epigenetic global methylation, is presented by Erkan Tüzel, Utkan Demirci, and co-workers in article number 1700531. The image shows the Simple Periodic ARray for Trapping And isolatioN (SPARTAN) device sorting the unshapely and damaged sperm (in pink) from healthier sperm (blue). The unshapely sperm are diverted by the pillars in the device going in circles and do not emerge from the labrynth of the pillars in the system. In the image, pink and blue colors are used for illustration purposes only and do not denote the presence of an X or Y chromosome.
A VLSI architecture for lifting-based wavelet transform (2002)

The discrete wavelet transform (DWT) is the basis for many image compression techniques, such as the upcoming JEPG2000. Lifting-based DWT requires fewer computations compared to the traditional convolution-based approach. In this paper, we propose a VLSI architecture to compute lifting-based 2D DWT, for a set of seven filters recommended in the JPEG2000 verification model. The architecture produces transform coefficients in every clock cycle for three of the filters and in every alternate cycle for the rest of the filters. We also present an efficient memory organization to address the high memory bandwidth requirements. The performance metrics of the proposed architecture have also been furnished.
Recent Progress in Nanostructured Thin Film (NSTF) ORR Electrocatalyst Development for PEM Fuel Cells (2015)

In this paper, we provide an overview of several recent development activities towards improving the activity of nanoporous Pt x Ni 1-x thin film electrocatalysts on the 3M Nanostructured Thin Film (NSTF) support. Significant improvements in electrocatalyst specific area and mass activity have been achieved through optimization of electrocatalyst fabrication parameters (deposition, annealing, and dealloying), which influence electrocatalyst composition and structure. Membrane electrode assemblies (MEAs) which incorporate improved NSTF Pt x Ni 1-x cathode catalysts have demonstrated performances which approach or exceed several U.S. Department of Energy 2020 performance and PGM-content targets.
First step toward an IP-based VHE (2001)

The Virtual Home Environment (VHE) appears as a key concept for the 3rd generation mobile networks such as the Universal Mobile Telecommunication System (UMTS). It promises mobile users the ability of accessing a large range of personalized services, whatever the location or the terminal. In fact, it allows the global service portability! Among other services, Internet/intranet applications are of course attractive targets. In parallel to the works on the VHE realization, the ongoing studies in the different standardization bodies (3GPP, 3GPP2, MWIF, IETF, 3GIP) indicate that the future telecommunication systems will be IP-based. If SIP and H.323 are natural candidates for voice over IP (VoIP) applications, Mobile IP could play an important part for the mobility management in those new generation networks. This IETF protocol allows transparent routing of IP datagrams to mobile nodes in the wide Internet. The purpose of this article is to describe the P920 VHE trial and how Mobile IP can be used as the mobility management protocol for an All-IP network, to offer a Web-based VHE and seamless services across different access networks (fixed LAN, WLAN, cellular, etc.). First, we give an overview of Mobile IP and the P920 vision of the VHE concept is then presented.
Airy beams: a geometric optics perspective (2010)

Theoretically formulated in the 1970s within the context of nonrelativistic quantum mechanics, Airy beams have been experimentally realized for the first time only recently, paving the way to innovative optical techniques. While their remarkable features, a non-diffracting property and a transverse shift of the intensity maximum during propagation, are currently theoretically described from the wave optics viewpoint, here their exact relation to rays and geometric wavefront aberrations is revealed using a wavefront family that includes two-dimensional Airy beams. Several members of this family are computationally and experimentally implemented here. The lateral shift of Airy beams during propagation is presented in the context of the three-dimensional caustic representation. This new description allows re-emphasizing the use of "Airy-like" beams in computational imaging for depth of focus extension.
Color Image Correlation: Principle And Application (1987)

Despite evidences from human vision research (1) that spatial and color characteristics of images are strongly related, the use of color for recognition purposes has received little attention. However,in the framework of the development of increasingly versatile machine vision systems, the introduction of the color feature seems to be a rather natural step. A color approach is obviously not always possible and justified and therefore we are interested in cases where color images are at hand and where recognition accuracy is more important than processing speed. In this work we extend the concepts introduced earlier (2) andpropose to find an optimal generalized color plane in which to carry out the correlation operation. The optimality is defined in terms of the maximization of the peak-to-deviation ratio in the correlation plane. As an application we consider the retrieval of the mucosal surface structure from stereo pairs taken through an endoscope.
High Performance and Low Energy Consumption in Phase Change Material RF Switches (2018)

This paper presents a RF to mm-wave switch based on Germanium Telluride phase change material. An integration process compatible with a standard CMOS back end of line is proposed to realize directly heated switches. RF measurements, performed up to 65 GHz, show an ON-state resistance of 1Ω with an OFF-state capacitance of 7 fF corresponding to a 22 THz cutoff frequency which constitutes a state-of-the-art Figure-of-Merit. Switching time of only 60 ns in both phase changes allow energy consumption one decade lower than the state-of-the-art for crystallization. A geometrical variation of GeTe dimensions shows a linear evolution of RF performance in terms of ON-state resistance and an almost unchanged performance in the OFF-state.
Disulfide-Based Diblock Copolymer Worm Gels: A Wholly-Synthetic Thermoreversible 3D Matrix for Sheet-Based Cultures (2015)

It is well-known that 3D in vitro cell cultures provide a much better model than 2D cell cultures for understanding the in vivo microenvironment of cells. However, significant technical challenges in handling and analyzing 3D cell cultures remain, which currently limits their widespread application. Herein, we demonstrate the application of wholly synthetic thermoresponsive block copolymer worms in sheet-based 3D cell culture. These worms form a soft, free-standing gel reversibly at 20-37 °C, which can be rapidly converted into a free-flowing dispersion of spheres on cooling to 5 °C. Functionalization of the worms with disulfide groups was found to be essential for ensuring sufficient mechanical stability of these hydrogels to enable long-term cell culture. These disulfide groups are conveniently introduced via statistical copolymerization of a disulfide-based dimethacrylate under conditions that favor intramolecular cyclization and subsequent thiol/disulfide exchange leads to the formation of reversible covalent bonds between adjacent worms within the gel. This new approach enables cells to be embedded within micrometer-thick slabs of gel with good viability, permits cell culture for at least 12 days, and facilitates recovery of viable cells from the gel simply by incubating the culture in buffer at 4 °C (thus, avoiding the enzymatic degradation required for cell harvesting when using commercial protein-based gels, such as Matrigel).
ChemInform Abstract: Indium‐Based Ultraviolet‐Transparent Electroconductive Oxyfluoride InOF: Ambient‐Pressure Synthesis and Unique Electronic Properties in Comparison with In2O3. (2013)

Abstract Single‐phase, powdered InOF is prepared by thermal decomposition of InF 3 ·3H 2 O under flowing O 2 (360—440 °C, 2 h).
Correction to “Insights into π-Conjugated Small Molecule Neat Films and Blends As Determined Through Photoconductivity” (2013)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionCorrection to "Insights into π-Conjugated Small Molecule Neat Films and Blends As Determined Through Photoconductivity"Jacek J. Jasieniak, Ben B.Y. Hsu, Christopher J. Takacs, Gregory C. Welch, Guillermo C. Bazan, Daniel Moses, and Alan J. Heeger*Cite this: ACS Nano 2013, 7, 2, 1824Publication Date (Web):January 16, 2013Publication History Published online16 January 2013Published inissue 26 February 2013https://pubs.acs.org/doi/10.1021/nn4001319https://doi.org/10.1021/nn4001319correctionACS PublicationsCopyright © 2013 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views787Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (1 MB) Get e-AlertscloseSUBJECTS:Deposition,Photonics,Physical and chemical processes,Thin films Get e-Alerts
Deux ans de fièvre catarrhale ovine en Corse (2002)

La fièvre catarrhale du mouton est une maladie virale transmise par des insectes du genre Culicoides. Elle affecte de nombreuses espèces de ruminants et notamment les ovins avec une incidence économique parfois importante par la morbidité, la mortalité, les pertes de production et les restrictions réglementaires qu'elle entraîne. La progression de la maladie dans le bassin méditerranéen depuis 2000 a conduit à la déclaration de l'infection en Corse en octobre 2000 et à son maintien en 2001. L'arrivée et la gestion de cette maladie jusqu'alors considérée comme tropicale (au sud de la Méditerranée) représente un enjeu particulier pour les éleveurs, les vétérinaires praticiens et les services vétérinaires par l'importance de l'atteinte du cheptel corse, la nécessité d'adapter les outils et méthodes de gestion à une maladie vectorielle, les risques d'extension de l'infection ainsi que la nécessité de placer son éradication comme objectif prioritaire pour l'avenir de l'élevage en Corse. Afin d'illustrer l'ensemble de ces enjeux, nous présenterons une synthèse des principales données disponibles sur la fièvre catarrhale du mouton en Corse ainsi que les programmes de surveillance mis en place pour permettre une gestion optimale de la maladie et effectuer une approche prospective de son évolution.
Marine Natural Products as Prototype Agrochemical Agents (2003)

In the interest of identifying new leads that could serve as prototype agrochemical agents, 18 structurally diverse marine-derived compounds were examined for insecticidal, herbicidal, and fungicidal activities. Several new classes of compounds have been shown to be insecticidal, herbicidal, and fungicidal, which suggests that marine natural products represent an intriguing source for the discovery of new agrochemical agents.
Management of the chronically dislocated patella during total knee arthroplasty (1988)

The chronically dislocated patella is usually associated with fixed valgus and often with fixed-tlexion deformities. All components of the deformity must be addressed to achieve a satisfactory result following total knee arthroplasty. The proper rotation of the tibial and femoral components is critical, and slight external rotation of either component will assist patellar tracking. Extensor mechanism realignment is performed proximally, usually with the “tube” realignment technique or occasionally with a Coonse-Adams extensor turndown technique. Distal extensor realignment is discouraged. Cemented implants are preferable; metal-backed patellar components should be avoided. Postoperative rehabilitation is modified to protect the extensor mechanism repair.