gebhart/patrepeval huggingface dataset:
In vivo Clinical and Intravital Imaging with MEMS based Dual-Axes Confocal Microscopes (2009)

We demonstrate fast microelectromechanical systems (MEMS) based near infrared fluorescence dual-axes confocal imaging modality in both a 10-mm microscope and a 5-mm endoscope for three-dimensional (3-D) imaging of both ex vivo and in vivo samples. The miniature probe can be placed into contact with the target tissue to reveal sub-surface histology at depths of up to 300 µm. The probe has a maximum field of view (FOV) of 800×450 µm2 and a maximum acquisition rate of 5 frames/second. The lateral and axial resolutions are 5 µm and 7 µm, respectively.
Determination of the first satellite valley energy in the conduction band of wurtzite GaN by near-band-gap photoemission spectroscopy (2014)

The position of the first satellite valley in wurtzite GaN is directly determined by near-band-gap photoemission spectroscopy of $p$-doped GaN activated to negative electron affinity. The photoemission spectra exhibit two structures, with fixed energy position, which originate from electrons accumulated in the conduction band valleys of the bulk material. We assigned the two observed features respectively to $\ensuremath{\Gamma}$ and L valleys and obtain an intervalley energy separation of $0.90\ifmmode\pm\else\textpm\fi{}0.08$ eV, well below the theoretical values of the lowest subsidiary valley energy provided by ab initio calculations.
Learning Execution Contexts from System Call Distribution for Anomaly Detection in Smart Embedded System (2017)

Existing techniques used for anomaly detection do not fully utilize the intrinsic properties of embedded devices. In this paper, we propose a lightweight method for detecting anomalous executions using a distribution of system call frequencies. We use a cluster analysis to learn the legitimate execution contexts of embedded applications and then monitor them at run-time to capture abnormal executions. Our prototype applied to a real-world open-source embedded application shows that the proposed method can effectively detect anomalous executions without relying on sophisticated analyses or affecting the critical execution paths.
Circulating and Intratumoral Adrenal Androgens Correlate with Response to Abiraterone in Men with Castration-Resistant Prostate Cancer (2021)

Low-circulating adrenal androgen levels are strongly associated with an androgen-poor tumor microenvironment and with poor response to AA. Patients with CRPC with higher serum DHEAS levels may benefit from dual androgen receptor (AR)-pathway inhibition, while those in the lowest quartile may require combinations with non-AR-directed therapy.
Local broadcasting in the physical interference model (2008)

In this work we analyze the complexity of local broadcasting in the physical interference model. We present two distributed randomized algorithms: one that assumes that each node knows how many nodes there are in its geographical proximity, and another, which makes no assumptions about topology knowledge. We show that, if the transmission probability of each node meets certain characteristics, the analysis can be decoupled from the global nature of the physical interference model, and each node performs a successful local broadcast in time proportional to the number of neighbors in its physical proximity. We also provide worst-case optimality guarantees for both algorithms and demonstrate their behavior in average scenarios through simulations.
Changes in DNA Methylation in Mouse Lungs after a Single Intra-Tracheal Administration of Nanomaterials (2017)

Epigenetics may be implicated in NM-induced disease pathways.
Security and Control in the Cloud (2010)

ABSTRACT Cloud computing is a new IT delivery paradigm that offers computing resources as on-demand services over the Internet. Like all forms of outsourcing, cloud computing raises serious concerns about the security of the data assets that are outsourced to providers of cloud services. To address these security concerns, we show how today's generation of information security management systems (ISMSs), as specified in the ISO/IEC 27001:2005, must be extended to address the transfer of security controls into cloud environments. The resulting virtual ISMS is a standards-compliant management approach for developing a sound control environment while supporting the various modalities of cloud computing. This article addresses chief security and/or information officers of cloud client and cloud provider organizations. Cloud clients will benefit from our exposition of how to manage risk when corporate assets are outsourced to cloud providers. Providers of cloud services will learn what processes and controls they can offer in order to provide superior security that differentiates their offerings in the market.
Positively charged microbubbles to target nucleic acid delivery with ultrasound (2015)

Congrès sous l’égide de la Société Française de Génie Biologique et Médical (SFGBM).
Denaturation and in Vitro Gastric Digestion of Heat-Treated Quinoa Protein Isolates Obtained at Various Extraction pH (2016)

The aim of this study was to determine the influence of heat processing on denaturation and digestibility properties of protein isolates obtained from sweet quinoa (<i>Chenopodium quinoa</i> Willd) at various extraction pH values (8, 9, 10 and 11). Pretreatment of suspensions of protein isolates at 60, 90 and 120 °C for 30 min led to protein denaturation and aggregation, which was enhanced at higher treatment temperatures. The in vitro gastric digestibility measured during 6 h was lower for protein extracts pre-treated at 90 and 120 °C compared to 60 °C. The digestibility decreased with increasing extraction pH, which could be ascribed to protein aggregation. Protein digestibility of the quinoa protein isolates was higher compared to wholemeal quinoa flour. We conclude that an interactive effect of processing temperature and extraction pH on in vitro gastric digestibility of quinoa protein isolates obtained at various extraction pH is observed. This gives a first indication of how the nutritional value of quinoa protein could be influenced by heat processing, protein extraction conditions and other grain components.
Self-Sterilizing Polymers: Controlled Release of Glutaraldehyde (1992)

α,β-unsaturated derivatives of 2-methoxy-2H-3,4-dihydropyran were synthesized. Stereochemical considerations of these heterocycles are briefly discussed. These compounds undergo a rapid first order reaction with water to produce glutaraldehyde, a potent microbial sterilant. Copolymers derived from these compounds and HEMA were found to provide excellent ex amples of clear, hard-sanitizing films; presumably by reaction with at mospheric moisture. Microbiological assays indicate that the release rates of the active agent from the polymers vary greatly depending on the hydrophilic ity of the comonomers.
An Alternative Role of C1q in Bacterial Infections: Facilitating Streptococcus pneumoniae Adherence and Invasion of Host Cells (2013)

Streptococcus pneumoniae (pneumococcus) is a major human pathogen, which evolved numerous successful strategies to colonize the host. In this study, we report a novel mechanism of pneumococcal-host interaction, whereby pneumococci use a host complement protein C1q, primarily involved in the host-defense mechanism, for colonization and subsequent dissemination. Using cell-culture infection assays and confocal microscopy, we observed that pneumococcal surface-bound C1q significantly enhanced pneumococcal adherence to and invasion of host epithelial and endothelial cells. Flow cytometry demonstrated a direct, Ab-independent binding of purified C1q to various clinical isolates of pneumococci. This interaction was seemingly capsule serotype independent and mediated by the bacterial surface-exposed proteins, as pretreatment of pneumococci with pronase E but not sodium periodate significantly reduced C1q binding. Moreover, similar binding was observed using C1 complex as the source of C1q. Furthermore, our data show that C1q bound to the pneumococcal surface through the globular heads and with the host cell-surface receptor(s)/glycosaminoglycans via its N-terminal collagen-like stalk, as the presence of C1q N-terminal fragment and low m.w. heparin but not the C-terminal globular heads blocked C1q-mediated pneumococcal adherence to host cells. Taken together, we demonstrate for the first time, to our knowledge, a unique function of complement protein C1q, as a molecular bridge between pneumococci and the host, which promotes bacterial cellular adherence and invasion. Nevertheless, in some conditions, this mechanism could be also beneficial for the host as it may result in uptake and clearance of the bacteria.
Si-based CTE-matched substrate for laser diode packaging (2023)

A Cu—Si—Cu substrate having a silicon substrate, copper plating on opposite sides of the silicon substrate, and copper vias extending thru the silicon substrate to electrically and thermally connect the copper platings together. The thicknesses of the silicon substrate and the copper platings are selected so that a coefficient of thermal expansion (CTE) of the Cu—Si—Cu substrate is substantially the same as a CTE of a material to be mounted on the Cu—Si—Cu substrate.
Tuning the Semiconducting Properties of Sexithiophene byα,ω-Substitution—α,ω-Diperfluorohexylsexithiophene: The First n-Type Sexithiophene for Thin-Film Transistors (2000)

The first substituent-induced “flip” from p- to n-type conductivity as well as enhanced thermal stability and volatility are found for fluorocarbon-functionalized sexithiophene 1 (relative to the fluorine-free analogues 2 and 3). Evaporated films of 1 behave as n-type semiconductors, and can be used to fabricate thin-film transistors with field-effect mobilities as high as 0.02 cm2 V−1 s−1—some of the highest reported to date for n-type organic semiconductors.
Over 10-times high-speed, energy efficient 3D TSV-integrated hybrid ReRAM/MLC NAND SSD by intelligent data fragmentation suppression (2013)

A 3D through-silicon-via (TSV)-integrated hybrid ReRAM/multi-level-cell (MLC) NAND solid-state drive's (SSD's) architecture is proposed with NAND-like interface (I/F) and sector-access overwrite policy for ReRAM. Furthermore, intelligent data management algorithms are proposed to suppress data fragmentation and excess usage of MLC NAND. As a result, 11-times performance increase, 6.9-times endurance enhancement and 93% write energy reduction are achieved. Both ReRAM write and read latency should be less than 3 μs to obtain these improvements. The required endurance for ReRAM is 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sup> .
ACS Chemical Neuroscience Molecule Spotlight on BMS-708163 (2012)

BMS-708163 is a novel, sulfonamide containing γ-secretase inhibitor from Bristol-Myers Squibb Co. currently in Phase II clinical trials for the treatment of Alzheimer's disease (AD).
A System-Level Simulation Framework for UWB Localization (2010)

In this paper we present a comprehensive simulation framework that can accurately simulate our indoor UWB positioning system including the analog front-ends, digital back-ends, and channel effects. Experimental results from our UWB positioning system are compared to simulated results to validate the accuracy of the simulation framework. Simulated results illustrate the design decisions made in optimizing overall system performance. Multiple peak detection algorithms are presented, and the robustness of our leading-edge detection algorithm is shown even in dense multipath environments. Geometric effects are examined by simulating various base station configurations. This comprehensive simulation framework provides an in-depth analysis of our UWB positioning system and also provides a general framework for rapid prototyping and design of complex wireless systems.
Protection Strategies Enable Selective Conversion of Biomass (2020)

Abstract Selective and economic conversion of lignocellulosic biomass components to bio‐based fuels and chemicals is the major goal of biorefineries, but low yields and selectivity for fuel precursors such as sugars, furanics, and lignin‐derived monomers pose significant disadvantages in process economics. In this Minireview we summarize the existing protection strategies used in biomass chemocatalytic conversion processes and focus the discussions on the mechanisms, challenges, and opportunities of each strategy. We introduce a concept of using analogous methods to manipulate biomass catalytic conversion pathways during the upgrading of carbohydrates to fuels and chemicals. This Minireview may provide new insights into the development of selective biorefining processes from a different perspective, expanding the options for selective conversion of biomass to fuels and chemicals.
Thermal lens calorimetry for flowing samples (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThermal lens calorimetry for flowing samplesN. J. Dovichi and J. M. HarrisCite this: Anal. Chem. 1981, 53, 4, 689–692Publication Date (Print):April 1, 1981Publication History Published online1 May 2002Published inissue 1 April 1981https://pubs.acs.org/doi/10.1021/ac00227a026https://doi.org/10.1021/ac00227a026research-articleACS PublicationsRequest reuse permissionsArticle Views139Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Supplementary Tables 1 - 3 from Integration of Distinct ShcA Signaling Complexes Promotes Breast Tumor Growth and Tyrosine Kinase Inhibitor Resistance (2023)

&lt;p&gt;Supplementary Table 1: List of differentially expressed genes comprising the ShcA-PTBMUT-like gene signature (GEO GSE41718) used for Figure S7. Supplementary Table 2: Antibodies used for immunoblot analysis (referred to in the supplementary methods). Supplementary Table 3: Antibodies used for immunohistochemistry (referred to in the supplementary methods).&lt;/p&gt;
Nickel-catalyzed decarbonylation of N-acylated N-heteroarenes (2019)

Nickel-catalyzed decarbonylation of <i>N</i>-acylated N-heteroarenes is developed. This method can be used to produce a variety of <i>N</i>-aryl heteroarenes, including pyrroles, indoles, carbazoles and phenoxazines, using benzoic acid derivatives as arylating reagents. Arylnickelamide intermediates that are relevant to the catalytic reaction were characterized by X-ray crystallography. When <i>N</i>-acylated benzimidazoles are used as substrates, decarbonylation accompanied 1,2-migration to form 2-arylated benzimidazoles.
Frequency domain estimation of 3-D rigid motion based on range and intensity data (2002)

Video-rate registered range and intensity data are at reach of current sensor technology. This wealth of data can be profitably exploited in order to estimate rigid motion parameters as the approaches to 3-D motion estimation, based on the optical flow of both types of data, indicate. This work introduces an alternative for 3-D motion estimation based on the Fourier transform of the 3-D intensity function implicitly described by the registered time-sequences of range and intensity data. The proposed procedure can lead to an unsupervised method for 3-D rigid motion estimation. This method has several advantages related to the fact that it uses the total available information and not sets of features. With respect to memory occupancy the use of a time-sequence of a 3-D intensity function represents a considerable data reduction with respect to a pair of time-sequences of 2-D functions. The proposed technique, which extends to the 3-D case previous frequency domain estimation algorithms developed for the planar case, retain their robustness.
Assessment of Systemic Delivery of rAAVrh74.MHCK7.micro-dystrophin in Children With Duchenne Muscular Dystrophy (2020)

ClinicalTrials.gov Identifier: NCT03375164.
Particulate carrier systems as adjuvants for cancer vaccines (2019)

To overcome the immunosuppressive milieu of malignancy and lack of well-defined antigens, potent adjuvants are needed for cancer immunotherapy. Numerous small molecular immunomodulators have the potential to fulfill this role. To enhance the immune response and decrease the toxicity, particulate systems including nanoparticles and macroparticles have been increasingly proposed as carriers for cancer antigen and adjuvant delivery. These systems have the potential to co-deliver the antigens and adjuvants simultaneously in the same particle. In addition, the particles can be engineered for localized and targeted delivery, whether it be to the cellular or sub-cellular level. These properties limit systemic side effects and improve delivery efficiency, and thus enhance the vaccine's immune response. In particular, the particles can be constructed to mimic the size and surface patterns of microbes, organisms to which we have evolved a strong immune response. The release characteristics of the particles can likewise be controlled to simulate the body's response to infections. Boosting the immune response of vaccines by virtue of their intrinsic immunostimulatory properties, these particles can be dosing-sparing and have the potential to reduce production cost of vaccines. As the interest in personalized cancer vaccines increases with their encouraging outcomes in clinical trials, particulate carrier systems have the potential to play an important role in optimizing cancer vaccines.
Adaptive blood pressure estimation from wearable PPG sensors using peripheral artery pulse wave velocity measurements and multi-channel blind identification of local arterial dynamics (2006)

A method for estimating pulse wave velocity (PWV) using circulatory waveform signals derived from multiple photoplethysmograph (PPG) sensors is described. The method employs two wearable in-line PPG sensors placed at a known distance from one another at the ulnar and digital artery. A technique for calibrating the measured pulse wave velocity to arterial blood pressure using hydrostatic pressure variation is presented. Additionally, a framework is described for estimating local arterial dynamics using PPG waveforms and multi-channel blind system ID. Initial results implementing the method on data derived from a human subject at different arterial pressures is presented. Results show that the method is capable of measuring the changes in arterial PWV that result from fluctuations in mean arterial pressure
New PCB Winding ”Snake-Core” Matrix Transformer for Ultra-Compact Wide DC Input Voltage Range Hybrid B+DCM Resonant Server Power Supply (2018)

Given the demand for higher power density, higher efficiency and lower realization cost solutions in data centers, dc-dc converters using PCB winding magnetics and resonant operation have been intensively studied in literature. In this paper, a new approach for 300V-430V dc input and 12V dc output server power supplies is proposed, which is based on a series resonant converter topology using a synergy between boundary and discontinuous conduction mode operation, whereby low peak-to-average ratio transformer current waveforms, soft-switching throughout the full power range and tight regulation of the output voltage for a wide input voltage range are achieved. Furthermore, a PCB winding ”snake-core” matrix transformer is introduced, which provides only a single path for the magnetic flux and therefore ensures an equal flux linkage and/or induced voltage of the parallel-connected secondary windings despite possible geometric PCB layout asymmetries. This approach avoids the emergence of circulating currents between parallel-connected secondary windings and guarantees at the same time equal secondary-side voltages in power supplies with multiple isolated outputs. Thus, a higher degree of freedom in the design of the primary windings of PCB winding-integrated transformers is achieved, whereby the design of these transformers is considerably simplified.
Oxidation of unsaturated aliphatic and arylalkyl alcohols by peroxydisulphate. Intramolecular cyclization of alkoxyl radicals (1980)

Oxidation of unsaturated aliphatic and arylalkyl alcohols by the sodium peroxydisulphate–silver salt system has been studied. Both classes of alcohols lead to cyclic ethers through different pathways. The ratio of five- to six-membered cyclic ethers was established reliably by trapping the corresponding cyclic radicals with heteroaromatic bases. Since a general preference for the formation of the five-membered ring was observed, comparison has been made with other oxidizing systems. The products obtained are also interesting from the synthetic point of view.
Proton and phosphorus-31 NMR investigations of actinomycin D binding selectivity with oligodeoxyribonucleotides containing multiple adjacent d(GC) sites (1988)

Imino proton and 31P NMR studies were conducted on the binding of actinomycin D (ActD) to self-complementary oligodeoxyribonucleotides with adjacent 5'-GC-3' sites. ActD showed very high specificity for binding to GC sites regardless of oligomer length and surrounding sequence. For a first class of duplexes with a central GCGC sequence, a mixture of 1:1 complexes was observed due to the two different orientations of the ActD phenoxazone ring system. Analysis of 1H chemical shifts suggested that the favored 1:1 complex had the benzenoid side of the phenoxazone ring over the G base in the central base pair of the GCGC sequence. This is the first case in which an unsymmetrical intercalator has been shown to bind to DNA in both possible orientations. A unique 2:1 complex, with significantly different 1H and 31P chemical shifts relative to those of the 1:1 complexes, was formed with these same oligomers, again with the benzenoid side of the ActD molecule over the G base of the central GC base pair. There is considerable anticooperativity to binding of the second ActD in a GCGC sequence. In titrations of oligomers with the GCGC sequence, only the two 1:1 complexes are found up to ratios of one ActD per oligomer. Increasing the ActD concentration, however, resulted in stoichiometric formation of the unique 2:1 adduct. Spectrophotometric binding studies indicated that the apparent binding equilibrium constant for a GC site adjacent to a bound site is reduced by approximately a factor of 20 relative to the ActD binding constant to an isolated GC site.