gebhart/patrepeval huggingface dataset:
Human CD4 + /CD8α + regulatory T cells induced by Faecalibacterium prausnitzii protect against intestinal inflammation (2022)

ABSTRACT Faecalibacterium prausnitzii (F. prausnitzii) , a dominant bacterium of the human microbiota, is decreased in patients with inflammatory bowel diseases (IBD) and exhibits anti-inflammatory effects. In human, colonic lamina propria contains IL-10-positive, Foxp3-negative regulatory T cells (Treg) characterized by a double expression of CD4 and CD8α (DP8α) and a specificity for F. prausnitzii . This Treg subset is decreased in IBD. The in vivo effect of DP8α cells has not been evaluated yet. Here, using a humanized model of NOD. Prkcscid IL2rγ -/- (NSG) immunodeficient mouse strain that expresses human leucocyte antigen D-related 4 (HLA-DR4) but not murine class II (NSG-Ab° DR4), we demonstrated a protective effect of DP8α Tregs combined with F. prausnitzii administration in a colitis model. In a cohort of patients with IBD, we showed an independent association between the frequency of circulating DP8α cells and disease activity. Finally, we pointed out a positive correlation between F. prausnitzii -specific DP8α Tregs and the amount of F. prausnitzii in fecal microbiota in healthy individuals and patients with ileal Crohn’s disease.
Studies on the effect of Schizandra chinensis extract on horses submitted to exercise and maximum effort (1989)

Abstract The effect of the berries extract of Schizundru chinensis on polo and race horses was studied. The concentration of plasmatic lactate and glucose as well as the respiratory and heart rates of these horses submitted to daerent physical effort were examined. Thirty adult horses were used for this experiment; 20 polo horses and 10 race horses. Ten polo horses were submitted to a 12 min gallop at a speed of 400 m/min, and 10 other polo horses to a 5 min gallop at a speed of 700 m/min. The race horses were submitted to a single run on a fixed distance of 800111 at maximum speed. Blood jugular samples from each polo horse (when they were in the stable) were collected for lactate and glucose analysis before the exercise and at 10 and 50 min after the exercise. Heart and respiratory rates were recorded. First each horse was given a single dose of 500 mL of saline half an hour before the race. A week later the same horses were given a single dose of 48 g of Schizundru chinemis berry extract. Treated polo horses showed a lower increase in heart rate at all moments of the exercise. They also showed a quicker recovery of respiratory frequency at the moments immediately after the race (time 0) and 5 min after the same race. The performance of the race horses was improved. In polo horses administration of Schizundru extract led to a significant reduction of the concentration of plasmatic lactate at 10, and 50min after exercise. Plasma glucose concentration in polo horses showed no significant difference between the saline treated and the Schizandru ‐treated animals (with the exception at 50 min after the race).
An electron-transporting host material compatible with diverse triplet emitters used for highly efficient red- and green-electrophosphorescent devices (2008)

A bifluorene analogue, T2N, containing a pyridyl moiety serves as both a host and an efficient electron-transporting material that is compatible with various heavy metal-containing red (Ir, Ru, Os, and Pt) and green (Ir) phosphors for highly efficient phosphorescent OLEDs possessing simple device architectures.
Molecular cloning and expression of the rat beta 1-adrenergic receptor gene. (1990)

Using the sequence homology approach for cloning related genes within the G-protein-coupled receptor gene family, we have cloned the gene for the rat beta 1-adrenergic receptor (beta 1-AR). The rat beta 1-adrenergic receptor gene was isolated from a lambda EMBL3 rat genomic DNA library using the hamster beta 2-adrenergic receptor (beta 2-AR) coding sequence as a probe under low stringency hybridization conditions. The rat beta 1-AR gene encodes a protein of 466 amino acids that contains one consensus site for N-linked glycosylation (Asn-15) and three consensus sites for cAMP-dependent protein kinase phosphorylation (Ser-296, Ser-301, and Ser-401). The encoded rat beta 1-AR is 98 and 91% similar at the amino acid level with the human beta 1-AR in the transmembrane domains and in the overall sequence, respectively. Genomic Southern blot and gene dosage analyses indicate that the rat beta 1-AR gene is a single copy gene. The tissue distribution of the rat beta 1-AR mRNA was highest in the pineal gland with other brain regions and peripheral tissues, including the heart, expressing the mRNA at moderate levels. The bacteriophage clone containing the rat beta 1-AR gene with its natural promoter was co-transfected with the selectable marker (pRSVneo) conferring neomycin resistance into beta 1-AR-deficient mouse L cells. Analyses of the selected transfectant demonstrates efficient expression of the beta 1-AR gene and functional receptor. 125I-Labeled iodocyanopindolol bound transfectant membranes with an affinity of KD = 24 pm; the beta 1-AR-selective antagonist ICI 89,406 displaced iodocyanopindolol binding with a Ki approximately 140 times lower than that for the beta 2-AR-selective antagonist ICI 118,551. In addition, in the transfectant cell line, adenylylcyclase was stimulated by beta-adrenergic receptor agonists with the rank order of potency of isoproterenol greater than norepinephrine = epinephrine, consistent with properties expected of the beta 1-AR subtype.
Corporate Governance and Equity Liquidity: analysis of S&P transparency and disclosure rankings (2007)

This paper sets out to investigate the effects of disclosure, and other corporate governance mechanisms, on equity liquidity, arguing that those companies adopting poor information transparency and disclosure practices will experience serious information asymmetry. Since poor corporate governance leads to greater information asymmetry, liquidity providers will incur relatively higher adverse information risks and will therefore offer higher information asymmetry components in their effective bid‐ask spreads. The Transparency and Disclosure (T&amp;D) rankings of the individual stocks on the S&amp;P 500 index are employed to examine whether firms with greater T&amp;D rankings have lower information asymmetry components and lower stock spreads. Our results reveal that the economic costs of equity liquidity, i.e. the effective spread and the quoted half‐spread, are greater for those companies with poor information transparency and disclosure practices.
Ochraceopyronide, a Rare α-Pyrone-C-lyxofuranoside from a Soil-Derived Fungus Aspergillus ochraceopetaliformis (2021)

The fungal strain was isolated from a soil sample collected in Giza province, Egypt, and was identified as <i>Aspergillus</i>&nbsp;<i>ochraceopetaliformis</i> based on phenotypic and genotypic data. The ethyl acetate extract of the fungal strain exhibited promising activity levels against several pathogenic test organisms and through a series of <sup>1</sup>H NMR guided chromatographic separations, a new α-pyrone-C-lyxofuranoside (<b>1</b>) along with four known compounds (<b>2</b>-<b>5</b>) were isolated. The planar structure of the new metabolite was elucidated by detailed analysis of its 1D/2D NMR and HRMS/IR/UV spectroscopic data, while the relative configuration of the sugar moiety was determined by a combined study of NOESY and coupling constants data, with the aid of theoretical calculations. The structures of the known compounds-isolated for the first time from <i>A</i>. <i>ochraceopetaliformis</i>-were established by comparison of their spectroscopic data with those in the literature. All isolated fungal metabolites were evaluated for their antibacterial and antifungal activities against six Gram-positive and Gram-negative bacteria as well as against three human pathogenic fungi.
Mixing and matching causing taper wear (2012)

We report a case of a male patient presenting with bilateral painful but apparently well-positioned and -fixed large-diameter metal-on-metal hip replacements four years post-operatively. Multiple imaging modes revealed a thick-walled, cystic expansile mass in communication with the hip joint (a pseudotumour). Implant retrieval analysis and tissue culture eliminated high bearing wear or infection as causes for the soft-tissue reaction, but noted marked corrosion of the modular neck taper adaptor and corrosion products in the tissues. Therefore, we believe corrosion products from the taper caused by mismatch of the implant components led to pseudotumour formation requiring revision.
Delocalized Hot Electron Generation with Propagative Surface Plasmon Polaritons (2019)

Hot electrons generated within plasmonic structures possess a high kinetic energy that can be employed to drive and catalyze a huge range of physicochemical processes at the metallic interface. Up to now, these photogenerated hot carriers were mainly generated within simple plasmonic nanoparticles where hot carrier localization coincides spatially with the position optical excitation. A current challenge for the development of future plasmonic-based hot electron devices requires the ability for a delocalized hot carrier production to control on a large-distance their spatial distribution. Here, we demonstrate the remote generation of hot electrons by launching a propagative surface plasmon on a gold waveguide. Such hot carriers can be produced at distances of several microns from the excitation. Moreover, using far- and near-field hyperspectral microscopy, we show that hot carriers present spatial and energy distributions driven by the propagating plasmon field distribution itself. This opens the door to the engineering of complex hot carrier devices through the management of the plasmon propagation for next level hot-electron-based applications.
Terahertz plasmonic cavities and crystals: coherent phenomena in 2D electronic systems. (2012)

Abstract not provided.
Cross-Training: A Semi-Supervised Training Scheme for Speech Recognition (2023)

Semi-supervised training can be performed by jointly optimizing supervised and unsupervised losses. In many settings, supervised and unsupervised losses are inconsistent, and this inconsistency creates instability in training. As a solution, we propose cross-training: instead of training one network with two losses, we train two separate networks, each with a different loss; we then tie the parameters of the networks by minimizing an additional L2 loss between the parameters. This L2 loss acts as a knowledge bridge between the networks. It forces the networks to be similar; therefore both can learn from each other. This paper introduces the cross-training scheme to develop a stable contrastive siamese (c-siam) network. Our experiments on LibriSpeech and Google’s Voice-Search/YouTube datasets show that (1) cross-training provides 20% relative WER improvement over the SOTA systems on the LibriSpeech dataset; (2) cross-training stabilizes c-siam training and significantly outperforms SOTA systems on small supervised datasets; (3) cross-training is effective for cascaded encoders, unlike the original c-siam which shows weak convergence characteristics.
Rotational diffusion of cell surface components by time-resolved phosphorescence anisotropy. (1979)

The rotational diffusion of concanavalin A receptors of viable Friend erythroleukemia cells and the band 3 anion transport system of human erythrocytes has been measured via the time-dependent phosphorescence emission intensity and anisotropy of triplet probes excited by a 5-ns laser pulse. High-quality phosphorescence decay curves with a 10-microseconds time resolution were obtained at concentrations of the eosin probe down to 20 nM and in aqueous media at temperatures of 4-38 degrees C. A strong temperature dependence in the rotational behavior was observed for the band 3 anion transport protein, but the lectin receptors of the Friend erythroleukemia cells were found to be immobile on the time scale of 1-4000 microseconds at either 4 degrees C or 37 degrees C. The technique is applicable to other triplet probes and membrane components of living cells under conditions that do not destroy viability.
Supplementary Table S2 from A Human Genome-Wide RNAi Screen Reveals Diverse Modulators that Mediate IRE1α–XBP1 Activation (2023)

&lt;p&gt;Pathway enrichment analysis using Reactome Skypainter.&lt;/p&gt;
Asymmetries for Elastic Scattering ofπ+from Polarized3Heand theΔ-Neutron Spin-Spin Interaction (1996)

Asymmetries for ${\ensuremath{\pi}}^{+}$ elastic scattering from polarized ${}^{3}\mathrm{He}$ were measured across the $\ensuremath{\Delta}$(1232) $\ensuremath{\pi}$-nucleon resonance region at incident energies ${T}_{\ensuremath{\pi}}\phantom{\rule{0ex}{0ex}}=\phantom{\rule{0ex}{0ex}}142$, 180, and 256 MeV. Large discrepancies were found between the data and calculations that use the multiple scattering formalism and Faddeev wave functions. Inclusion of a $\ensuremath{\Delta}$-neutron spin-spin interaction term in the calculations gives a greatly improved representation of the data.
Immunophenotyping of Stage III Melanoma Reveals Parameters Associated with Patient Prognosis (2016)

Stage III metastatic melanomas require adequate adjuvant immunotherapy to prevent relapses. Prognostic factors are awaited to optimize the clinical management of these patients. The magnitude of metastatic lymph node invasion and the BRAF(V600) activating mutation have clinical significance. Based on a comprehensive immunophenotyping of 252 parameters per patient in paired blood and metastatic lymph nodes performed in 39 metastatic melanomas, we found that blood markers were as contributive as tumor-infiltrated lymphocyte immunotypes, and parameters associated with lymphocyte exhaustion/suppression showed higher clinical significance than those related to activation or lineage. High frequencies of CD45RA(+)CD4(+) and CD3(-)CD56(-) tumor-infiltrated lymphocytes appear to be independent prognostic factors of short progression-free survival. High NKG2D expression on CD8(+)tumor-infiltrated lymphocytes, low level of regulatory T-cell tumor-infiltrated lymphocytes, and low PD-L1 expression on circulating T cells were retained in the multivariate Cox analysis model to predict prolonged overall survival. Prospective studies are needed to determine whether such immunological markers may guide adjuvant therapies in stage III metastatic melanomas.
Speckle Reducing Anisotropic Diffusion for Echocardiography (2006)

Echocardiographic segmentation accuracy significantly affects the calculation of important cardiac parameters, which assist in the understanding, diagnosis, and treatment of cardiovascular disease. This paper investigates extensions to speckle reducing anisotropic diffusion (SRAD) for the purpose of improving automated segmentation in echocardiographic imagery. We first investigate windowed SRAD (WSRAD), which attempts to increase edge contrast while preserving object size via the addition of neighborhood statistics to the SRAD diffusion coefficient. We also consider deconvolutional SRAD (DeSpeRADo), which attempts to alleviate blurring artifacts inherent to the ultrasound imaging system. We quantify the segmentation effects of each filtering method via simulated cardiac studies. With respect to unfiltered segmentation results, we measured a 21%, 24%, and 22% increase in myocardial segmentation accuracy with SRAD, WSRAD, and DeSpeRADo, respectively.
Microscopic and ultrastructural evidences in human skin following calcium hydroxylapatite filler treatment (2017)

This study uses light and electron microscopes to gain a better knowledge of the interactions of calcium hydroxylapatite filler with the connective tissue of the skin and the modifications of the human deep dermis, after 2 months of treatment. Some morphological evidences of this observational study of filler treated tissue support-specific mechanism involved in the structural modifications of both filler microspherules and cells of the connective tissue. They demonstrate the absence of any immunological reaction and show that the used filler is modified very slowly over time by the action of cells of the connective tissue closely related to the filler without any activity of phagocytosis. Furthermore, associated with the modifications of the filler, evidences of stimulatory effects on dermal fibroblasts are reported.
Model-Based Calibration of a Robotic C-Arm System Using X-Ray Imaging (2018)

In interventional radiology or surgery, C-arm systems are typical imaging modalities. Apart from 2D X-ray images, C-arm systems are able to perform 2D/3D overlays. For this application, a previously recorded 3D volume is projected on a 2D X-ray image for providing additional information to the clinician. The required accuracy for this application is 1.5[Formula: see text]mm. Such a spatial accuracy is only achievable with C-arms, if a calibration is performed. State-of-the-art approaches interpolate between values of lookup tables of a sampled Cartesian volume. However, due to the non-linear system behavior in Cartesian space, a trade-off between the calibration effort and the calibrated volume is necessary. This leads to the calibration of the most relevant subvolume and high calibration times. We discuss a new model-based calibration approach for C-arm systems which potentially leads to a smaller calibration effort and simultaneously to an increased calibrated volume. In this work, we demonstrate that it is possible to calibrate a robotic C-arm system using X-ray images and that a static model of the system is required to achieve the desired accuracy for 2D/3D overlays, if re-orientations of the system are performed.
Myocardial Infarction and Cerebrovascular Accident in Patients With Diabetic Macular Edema (2009)

A retrospective healthcare claims database cohort study was performed in DME subjects and diabetes controls matched for age and gender. The Ingenix LabRx DatabaseTM was used to identify subjects and outcomes during the study period from January 1, 2002 to December 31, 2005. International Classification of Diseases, 9th revision, Clinical Modification (ICD-9) codes were used to identify DME subjects, diabetes controls, MI, CVA, and covariates. Table 1 lists the selection criteria. Myocardial Infarction and Cerebrovascular Accident in Patients with Diabetic Macular Edema Bao-Anh Nguyen-Khoa1, Earl L Goehring Jr1, Winifred Werther2, and Judith K Jones1 1The Degge Group, Ltd., Arlington, VA, and 2Genentech, Inc., South San Francisco, CA, United States.
Distributed fiber optic chemical sensor for hydrogen sulfide and chlorine detection (2005)

Fiber optic sensors having their entire length as the sensing elements for chlorine or hydrogen sulfide are reported here. The chlorine fiber consists of a silica core and a chlorine-sensitive cladding, and the hydrogen sulfide fiber has a hydrogen sulfide sensitive cladding. Upon exposure to the corresponding challenge gas, the cladding very rapidly changes color resulting in attenuation of the light throughput of the fiber. A one-meter portion of the chlorine sensor fiber responds to 10 ppm chlorine in 20 seconds and to 1 ppm in several minutes. The attenuation after 10 minutes of exposure is very high, and is dependant on both chlorine concentration and fiber length. A ten-meter portion of the hydrogen sulfide sensor fiber responds to 100 ppm hydrogen sulfide in 30 seconds and to 10 ppm in 1 minute. The high sensitivity suggests that the propagating modes of the light interact strongly with the cladding, and that these interactions are massively increased (Beers Law) due to the extended sensor length. This approach will supersede the current method of having a collection of point-detectors to cover large areas.
Improved First-Order Time-Delay Tanlock Loop Architectures (2006)

This paper presents a study of the performance of the first-order time-delay digital tanlock loop (TDTL). It proposes a number of modified loop architectures that overcome some of the original TDTL design limitations. Simulation results indicate that the new architectures, which include delay switching, gain adaptation and a combination of both techniques, improve the TDTL performance in terms of acquisition speed, locking range and resilience to frequency disturbances. The first-order TDTL was also implemented on a field programmable gate array (FPGA). The real-time results from the FPGA implementation are in agreement with the ones obtained through simulation.
A single mutation at the catalytic site of TF1‐α3β3γ complex switches the kinetics of ATP hydrolysis from negative to positive cooperativity (1997)

Previously, we reported the substitution of Tyr341 of the F1-ATPase beta subunit from a thermophilic Bacillus strain PS3 with leucine, cysteine, or alanine (M. Odaka et al. J. Biochem., 115 (1994) 789-796). These mutations resulted in a great decrease in the affinity of the isolated beta subunit for ATP-Mg and an increase in the apparent Km of the alpha3beta3gamma complex in ATP hydrolysis when examined above 0.1 mM ATP. Here, we examined the ATPase activity of the mutant complexes in a wide range of ATP concentration and found that the mutants exhibited apparent positive cooperativity in ATP hydrolysis. This is the first clear demonstration that a single mutation in the catalytic sites converts the kinetics from apparent negative cooperativity in the wild-type alpha3beta3gamma complex to apparent positive cooperativity. The conversion of apparent cooperativity could be explained in terms of a simple kinetic scheme based on the binding change model proposed by Boyer.
Towards authentically labelled bi-modal PET(SPECT)/MR-probes (2014)

Application of radiolabelled, existing MRI probes using a suitable reporter group for multimodal PET(SPECT)/MRI imaging is limited due to the required alteration of the molecular structure and thus changing their in vivo properties. Radiolabelling of existing MRI contrast agents with PET(SPECT) isotopes of paramagnetic elements offers a simple way to address this issue. Therefore, new routes to the production of SPECT/PET-radionuclides 147,149Gd and 52gMn were examined which can be applied for n.c.a. labelling of Gd(III) and Mn(II) MRI contrast agents. Additionally, Mn(II)-based complexes stable for in vivo application are to be synthesized.

Reaction cross sections and experimental thick target yields were measured by irradiation of natCr or Eu2O3. Integral yields were calculated from measured excitation functions. A radiochemical separation of Mn from Cr was developed based on cation-exchange chromatography [1].

Cross section data of the natEu(d,x) and natEu(p,x) reactions were measured up to 70.9 MeV and 44.8 MeV, respectively. Integral yields of up to 177.3 MBq/μAh and 81.6 MBq/μAh for natEu(d,x)147,149Gd reactions and up to 43.3 MBq/μAh and 61.8 MBq/μAh for natEu(p,x)147,149Gd reactions, respectively, were calculated. Those were several times higher than for α- or 3He induced reactions on highly enriched 144Sm [2, 3].

With n.c.a. 52Mn, also cross sections of co-produced 48V, 48,49,51Cr, 52gMn were determined in the energy range of 7.6 to 45 MeV. The production rates of 52g,mMn were measured from 8.2 to 16.9 MeV with up to 13.1 MBq/μAh which was separated from natCr by column chromatography.

Production data of the SPECT nuclides 147,149Gd and the PET nuclide 52gMn were established. Different to Mn a practical isolation procedure for Gd is still required. Current work focuses on the radiolabelling of stable complexes of manganese (II) with the goal to develop PET/MRI tracers addressing molecular targets.