gebhart/patrepeval huggingface dataset:
Photodissociation of O2 via the Herzberg continuum: Measurements of O-atom alignment and orientation (2003)

Irradiation of molecular oxygen O2 in the region of the Herzberg continuum between 218 nm and 239 nm results in the production of open-shell photofragments O(3P)+O(3P). Product O(3Pj; j=0,1,2) atoms were ionized using resonantly enhanced multiphoton ionization (2+1 REMPI) near 225 nm and the ions collected in a velocity-sensitive time-of-flight mass spectrometer. By controlling the polarization of the photolysis and ionization radiation, we have measured alignment and orientation parameters of O-atom electronic angular momentum (j) in the molecule frame. The results show alignment from both parallel and perpendicular transitions that are cylindrically symmetric about the velocity (v) of the recoiling O atom. We also observe electronic alignment that is noncylindrically symmetric about v, resulting from coherence between multiply excited dissociative states. Photodissociation with linearly polarized light is shown to produce O atoms that are oriented in the molecule frame, resulting from interference between parallel and perpendicular dissociative states of O2. Semiclassical calculations that include spin–orbit coupling between six excited states reproduce closely the observed polarization.
P11-15. Induction of a mucosal immune response to HIV after systemic immunization with poly(lactic acid) nanoparticles formulated with gag antigen and polyI:C (2009)

Background To efficiently neutralize HIV at portals of entry, strong humoral responses are needed, associated to efficient cellular responses to avoid the dissemination of HIV in organism. If poly(lactic acid) (PLA) nanoparticles carrying HIV proteins have shown to induce a high systemic humoral immune response in mice, rabbit or macaque following sub-cutaneous administration, cellular and mucosal responses are still faint. Thus, to increase potency and specificity of mucosal immune responses, additional immunostimulatory signals, such as TLR ligands could be delivered with HIV antigens. The aim of this study was to compare the effect of co-administration of polyI:C, a TLR3 agonist, with PLA p24 nanoparticles on the mucosal and cellular responses in two animal models.
Direct mid-infrared spectroscopic measurements of hole relaxation in InGaAs/AlGaAs quantum wells (1995)

Measurements of infrared bleaching1 and anti-Stokes Raman scattering2 in n-type QWs have revealed an electron relaxation time ranging from less than 1 ps to 10 ps when the intersubband transition energy is larger than the LO phonon energy. The relaxation time depends on the excitation intensity and is influenced by intervalley scattering, LO-phonon screening, and hot phonons. In p-type quantum wells, the relaxation time is expected to be shorter because the density of states is larger and the band structure and the scattering mechanisms are different. Here, we report the first direct measurement of the relaxation time of holes in p-type quantum wells by the pumpprobe technique using ~1-ps pulses generated by a mid-infrared free-electron laser.
Multifunction Aperture for Vehicular Radar Integration (2007)

The current vision of active safety systems in future vehicles includes the use of both narrow field of view 77 GHz long range radar and wide field of view 24 GHz short range radar. The complexity of integrating both long range and short- range radar in the front of a vehicle is driving the need for new antenna approaches. This work describes the use of a spherical dielectric lens antenna with multiple 24 GHz and 77 GHz feeds located around the lens that creates multi-beam outputs with needed radiation patterns for each radar application from a single aperture. A prototype of this multifunction aperture was fabricated and measured.
The histological and elemental characterisation of corrosion particles from taper junctions (2016)

This study characterised and qualitatively graded the severity of the corrosion particles released into the hip joint from tapers that had corrosion damage.Cite this article: S. Munir, R. A. Oliver, B. Zicat, W. L. Walter, W. K. Walter, W. R. Walsh. The histological and elemental characterisation of corrosion particles from taper junctions. Bone Joint Res 2016;5:370-378. DOI: 10.1302/2046-3758.59.2000507.
CFD for the Study of the Multiphase Flow and Mass Transfer in a Stirred Tank Reactor for the Screening of Shaped Catalysts (2014)

International audience
Effect of Na 2 O Additions in the Crystallization of Barium Ferrite from a BaO‐B 2 O 3 ‐Fe 2 O 3 Glass (1996)

A glass crystallization method was utilized to synthesize nanosized BaO‐6Fe 2 O 3 platelets from a 0.412BaO‐0.258B 2 O 3 ‐0.330Fe 2 O 3 batch composition. Quenched ribbons were inhomogeneous, showing microclustering and ∼1 μm hematite crystals. Na 2 O substitutions for BaO greatly enhanced the glass‐forming tendency of quenched ribbons, though quenched‐in ∼0.5 μm barium ferrite crystals were infrequently present. The improved homogeneity with Na 2 O substitution was attributed to lower vapor pressure of BaO during batch melting, which increased its retention in the as‐quenched ribbons. Quantities of BaO equal to or in excess of Fe 2 O 3 allowed iron ions to adopt stable network positions in the glass melt. With Na 2 O substitution, devitrification of dispersed ∼40 nm barium ferrite particles from phase‐separated regions occurred after secondary heat treatment. 5 mol% Na 2 O batch substitution showed the lowest crystallinity in the as‐quenched ribbons, and the highest crystallinity after secondary heat treatment. After optimum devitrification, the maximum values of saturation magnetization and coercivity were 21.22 emu/g and 2.82 kOe, respectively.
Mechanism of Nitric Oxide Synthase. Evidence that Direct Hydrogen Atom Abstraction from the O−H Bond of NG-Hydroxyarginine Is Not Relevant to the Mechanism (2001)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTMechanism of Nitric Oxide Synthase. Evidence that Direct Hydrogen Atom Abstraction from the O−H Bond of NG-Hydroxyarginine Is Not Relevant to the MechanismHui Huang, Jung-Mi Hah, and Richard B. SilvermanView Author Information Department of Chemistry and Department of Biochemistry, Molecular Biology, and Cell Biology Northwestern University, Evanston, Illinois 60208-3113 Cite this: J. Am. Chem. Soc. 2001, 123, 11, 2674–2676Publication Date (Web):February 27, 2001Publication History Received19 December 2000Published online27 February 2001Published inissue 1 March 2001https://pubs.acs.org/doi/10.1021/ja005900uhttps://doi.org/10.1021/ja005900urapid-communicationACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views1907Altmetric-Citations51LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (10)»Supporting Information Supporting Information SUBJECTS:Bond cleavage,Hydrogen abstraction,Oxides,Oxygen,Peptides and proteins Get e-Alerts
Complexity-Reduced Adaptive PAPR Reduction Method Using Null Space in MIMO Channel for MIMO-OFDM Signals (2020)

This paper proposes a computational complexity-reduced algorithm for an adaptive peak-to-average power ratio (PAPR) reduction method previously developed by members of our research group that uses the null space in a multiple-input multiple-output (MIMO) channel for MIMO-orthogonal frequency division multiplexing (OFDM) signals. The proposed algorithm is an extension of the peak cancellation (PC) signal-based method that has been mainly investigated for per-antenna PAPR reduction. This method adds the PC signal, which is designed so that the out-of-band radiation is removed/reduced, directly to the time-domain transmission signal at each antenna. The proposed method, referred to as PCCNC (PC with channel-null constraint), performs vector-level signal processing in the PC signal generation so that the PC signal is transmitted only to the null space in the MIMO channel. We investigate three methods to control the beamforming (BF) vector in the PC signal, which is a key factor in determining the achievable PAPR performance of the algorithm. Computer simulation results show that the proposed PCCNC achieves approximately the same throughput-vs.-PAPR performance as the previous method while dramatically reducing the required computational cost.
Is INFUSE Bone Graft Superior to Autograft Bone? An Integrated Analysis of Clinical Trials Using the LT-CAGE Lumbar Tapered Fusion Device (2003)

Multicenter human clinical studies of patients undergoing anterior lumbar fusion have been conducted using recombinant bone morphogenetic protein or rhBMP-2 on an absorbable collagen sponge, marketed as INFUSE Bone Graft, or autograft implanted in the LT-CAGE Lumbar Tapered Fusion device. An integrated analysis of multiple clinical studies was performed using an analysis of covariance to adjust for preoperative variables in a total of 679 patients. Of these patients, 277 had their cages implanted with rhBMP-2 on an absorbable collagen sponge and 402 received autograft transferred from the iliac crest. The patients treated with rhBMP-2 had statistically superior outcomes with regard to length of surgery, blood loss, hospital stay, reoperation rate, median time to return to work, and fusion rates at 6, 12, and 24 months. Oswestry Disability Index scores and the Physical Component Scores and Pain Index of the SF-36 scale at 3, 6, 12, and 24 months showed statistically superior outcomes in the rhBMP-2 group.
Ligand Design and Preparation, Photophysical Properties, and Device Performance of an Encapsulated-Type Pseudo-Tris(heteroleptic) Iridium(III) Emitter (2023)

The organic molecule 2-(1-phenyl-1-(pyridin-2-yl)ethyl)-6-(3-(1-phenyl-1-(pyridin-2-yl)ethyl)phenyl)pyridine (<b>H</b><sub><b>3</b></sub><b>L</b>) has been designed, prepared, and employed to synthesize the encapsulated-type <i>pseudo</i>-tris(heteroleptic) iridium(III) derivative Ir(κ<sup>6</sup>-<i>fac-C,C',C″-fac-N,N</i>'<i>,N″-</i>L). Its formation takes place as a result of the coordination of the heterocycles to the iridium center and the <i>ortho</i>-CH bond activation of the phenyl groups. Dimer [Ir(μ-Cl)(η<sup>4</sup>-COD)]<sub>2</sub> is suitable for the preparation of this compound of class [Ir(9h)] (9h = 9-electron donor hexadentate ligand), but Ir(acac)<sub>3</sub> is a more appropriate starting material. Reactions were carried out in 1-phenylethanol. In contrast to the latter, 2-ethoxyethanol promotes the metal carbonylation, inhibiting the full coordination of <b>H</b><sub><b>3</b></sub><b>L</b>. Complex Ir(κ<sup>6</sup>-<i>fac-C,C',C″-fac-N,N</i>'<i>,N″-</i>L) is a phosphorescent emitter upon photoexcitation, which has been employed to fabricate four yellow emitting devices with 1931 CIE (x:y) ∼ (0.52:0.48) and a maximum wavelength at 576 nm. These devices display luminous efficacies, external quantum efficiencies, and power efficacies at 600 cd m<sup>-2</sup>, which lie in the ranges 21.4-31.3 cd A<sup>-1</sup>, 7.8-11.3%, and 10.2-14.1 lm W<sup>1-</sup>, respectively, depending on the device configuration.
Automatic Generation of Optimized Code for Marshalling Routines (1994)

Syntax Specification Notation 1) and the network data format BER (Basic Encoding Rules). These are used in all OSI application layer standards such as X.400 and X.500. However, they are also used outside the realms of OSI, e.g. for the WAIS information retrieval protocol, the SNMP network management protocol and parts of Signaling System 7. This paper is organized as follows: in Section 2, we discuss related work. In Section 3, we motivate the use of a hybrid approach between interpreted and compiled marshalling routines, by giving a detailed explanation and example code for both techiques. In Section 4, we discuss the problems of integrating our new approach into a stub generator, and develop solutions to these problems. Section 5 gives an outlook on future work. 2. Related Work The time spent in marshalling routines has been identified many times as a dominating factor in the overall cost of network communication ([Huit89], [Clar90], [Huit92]). [Lin93] recently challenged this resu...
Highly Efficient Two-Step Synthesis of C-sp3-Centered Geminal Diiodides (2004)

[reaction: see text] Trisubstituted gem-diiodoalkenes of functionalized chains are efficiently reduced to the corresponding terminal geminal diiodides in high yields upon treatment with the diazene precursor, diethyl 4-(hydrazinosulfonyl)-benzyl phosphonate.
Table S1 from First-in-Class ERK1/2 Inhibitor Ulixertinib (BVD-523) in Patients with MAPK Mutant Advanced Solid Tumors: Results of a Phase I Dose-Escalation and Expansion Study (2023)

&lt;p&gt;Tumor types and molecular alterations of enrolled patients&lt;/p&gt;
Kallikrein 13: a new player in coronaviral infections (2020)

ABSTRACT Human coronavirus HKU1 (HCoV-HKU1) is associated with respiratory disease and is prevalent worldwide, but in vitro model for virus replication is lacking. Interaction between the coronaviral spike (S) protein and its receptor is the major determinant of virus tissue and host specificity, but virus entry is a complex process requiring a concerted action of multiple cellular elements. Here, we show that KLK13 is required for the infection of the human respiratory epithelium and is sufficient to mediate the entry of HCoV-HKU1 to non-permissive RD cells. We also demonstrated HCoV-HKU1 S protein cleavage by KLK13 in the S1/S2 region, proving that KLK13 is the priming enzyme for this virus. Summarizing, we show for the first time that protease distribution and specificity predetermines the tissue and cell specificity of the virus and may also regulate interspecies transmission. It is also of importance that presented data may be relevant for the emerging coronaviruses, including SARS-CoV-2 and may help to understand the differences in their zoonotic potential.
Mechanistic Studies of Platinum(II)-Catalyzed Ethylene Dimerization:  Determination of Barriers to Migratory Insertion in Diimine Pt(II) Hydrido Ethylene and Ethyl Ethylene Intermediates (2007)

The diimine platinum(II) ethylene hydride complex [(N/\N)Pt(H)(ethylene)][BAr'4] (1, N/\N = [(2,6-Me2C6H3)N=C(An)-C(An)=N(2,6-Me2C6H3)], An = 1,8-naphthalenediyl, Ar' = 3,5-(CF3)2C6H3) was prepared by protonation of the diethyl complex (N/\N)PtEt2 with [H(OEt2)2][BAr'4]. The energy barrier to interchange of the platinum hydride with the olefinic hydrogens in 1 was determined to be 19.2 kcal/mol by spin saturation transfer experiments. Complex 1 initiates ethylene dimerization; the ethyl ethylene complex (N/\N)Pt(Et)(ethylene)+ (2) has been identified as the catalyst resting state. Trapping of 1 by ethylene to yield 2 is a second-order process; kinetic studies suggest this occurs via trapping of a reversibly formed beta-agostic ethyl complex. Complex 2 has been isolated and characterized by X-ray crystallography. The barrier to migratory insertion of 2, the turnover-limiting step in catalysis, was determined to be 29.8 kcal/mol. The 1-butene hydride complex, (N/\N)Pt(H)(1-butene)+ (3), is a key intermediate in the dimerization cycle and has also been isolated and characterized. Surprisingly rapid rates of degenerate associative exchange of free ethylene with bound ethylene in complexes 1 and 2 as well as the rate of degenerate exchange of free nitrile with bound nitrile in (N/\N)Pt(Et)(CH3CN)+ are reported.
Constitutive activity of the metabotropic glutamate receptor 2 explored with a whole-cell label-free biosensor (2018)

Label-free cellular assays using a biosensor provide new opportunities for studying G protein-coupled receptor (GPCR) signaling. As opposed to conventional in vitro assays, integrated receptor-mediated cellular responses are determined in real-time rather than a single downstream signaling pathway. In this study, we examined the potential of a label-free whole cell impedance-based biosensor system (i.e. xCELLigence) to study the pharmacology of one GPCR in particular, the mGlu<sub>2</sub> receptor. This receptor is a target for the treatment of several psychiatric diseases such as schizophrenia and depression. After optimization of assay conditions to prevent interference of endogenous glutamate in the culture medium, detailed pharmacological assessments were performed. Concentration-response curves showed a concentration-dependent increase in impedance for agonists and positive allosteric modulators, whereas receptor inhibition by an antagonist or negative allosteric modulator resulted in a concentration-dependent decrease in cellular impedance. Interestingly, constitutive receptor activity was observed that was decreased by LY341495, which therefore behaved as an inverse agonist here, a property that was heretofore unappreciated. This was confirmed by concentration-dependent modulation of LY341495 potency and efficacy by a allosteric modulators. In summary, the use of the xCELLigence system to study mGlu<sub>2</sub> receptor pharmacology was validated. This is the first class C GPCR to be characterized extensively by such method, opening new avenues to study receptor pharmacology including inverse agonism and demonstrating its value for future drug discovery efforts of mGlu receptors as well as other GPCRs.
An Attack on Privacy in Mobile Devices (2017)

This memo outlines an attack against the privacy of the Identities of
mobile devices with all the IETF secure enveloping technologies. It
describes necessary steps to be taken with those technologies, the
underlying address assignment strategies, and role of secure 3rd party
introducers.
High levels of DEK autoantibodies may predict early flare following cessation of anti-TNF therapy in juvenile idiopathic arthritis (2014)

The nuclear oncoprotein DEK is a biochemically distinct, pro-inflammatory protein that is a chemoattractant for neutrophils and T-cells. High levels of DEK autoantibodies have been found in several autoimmune diseases including juvenile idiopathic arthritis (JIA), but their role in disease pathogenesis is unclear.
Preparation and Properties of Proteinaceous Microspheres Made Sonochemically (2008)

In 1990, Suslick and co-workers developed a method in which they used high-intensity ultrasound to make aqueous suspensions of proteinaceous microcapsules filled with water-insoluble liquids, and demonstrated the chemical mechanism of their formation. Suslick's paper opened up a new field that is reviewed in the current manuscript, and this article will attempt to review the experiments that have been conducted since the discovery of this phenomenon. It will answer questions regarding the mechanism of the formation of the microspheres, whether the sonication denaturates the protein or if its biological activity is maintained, and, finally, will address possible applications of the proteinaceous microspheres. Proteinaceous microbubbles will be referred to as proteinaceous microspheres (PM) throughout this review, although they may not have a perfect spherical shape in all cases. This review will start with a short introduction to sonochemistry, although this topic is, and has been reviewed frequently. The review covers literature published until December 2006.
Interactions of Mammalian Cells with Collagen (1984)

Isolated stationary cells recognize and adhere to immobilized extracellular matrix (ECM) components. These processes are mediated by specific receptor-ligand types of interaction. The formation of cell-ECM contacts influences subsequent cellular behaviour, such as the promotion of cell survival, epithelial cell polarization, and cell differentiation. The binding reaction between cells and collagen is discussed in this paper in terms of findings from studies with two cell systems, adult rat hepatocytes and rat cardiac myocytes. Isolated adult rat hepatocytes adhere to or bind laminin, fibronectin, heparan sulphate and collagen. We have characterized the interaction of hepatocytes with collagen and have isolated a glycoprotein fraction from rat liver membranes that contains collagen-binding components. The ability of rat cardiac myocytes to recognize ECM components depends on the state of cell maturation. Myocytes isolated from neonatal rats adhere to the interstitial collagens (types I-III), to collagen types IV and V, to fibronectin and to laminin. In contrast, myocytes isolated from adult rats bind effectively only to collagen type IV and laminin and bind much less effectively to fibronectin. Furthermore, antibodies raised against neonatal myocyte membranes inhibit the adhesion of both neonatal myocytes and hepatocytes to interstitial collagens, but antibodies raised against adult myocyte membranes lack these effects. These observations indicate that similar collagen-binding molecules are present on such diverse cells as hepatocytes and neonatal myocytes and that these components might be lost during cell maturation.
Suzuki–Miyaura Diversification of Amino Acids and Dipeptides in Aqueous Media (2015)

Abstract The Suzuki–Miyaura derivatisation of free amino acids, peptides and proteins is an attractive area with considerable potential utility for medicinal chemistry and chemical biology. Here we report the modification of unprotected and Boc‐protected aromatic amino acids and dipeptides in aqueous media, enabling heteroarylation and vinylation. We systematically investigate the impact of the peptide backbone and adjacent amino acid residues upon the reaction. Our studies reveal that although asparagine and histidine hinder the reaction, by utilising dppf, a ferrocene‐based bidentate phosphine ligand, cross coupling of halophenylalanine or halotryptophan adjacent to such a residue could be enabled. Our studies reveal dppf to have good compatibility with all unprotected, proteinogenic amino acid side chains.