gebhart/patrepeval huggingface dataset:
Calculation of excited-state distortions and the missing-mode effect from the high-resolution emission spectrum of trans-bis[bis(diphenylphosphino)ethane]bis(dinitrogen)tungsten (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCalculation of excited-state distortions and the missing-mode effect from the high-resolution emission spectrum of trans-bis[bis(diphenylphosphino)ethane]bis(dinitrogen)tungstenLonda J. Larson and Jeffrey I. ZinkCite this: Inorg. Chem. 1989, 28, 18, 3519–3523Publication Date (Print):September 1, 1989Publication History Published online1 May 2002Published inissue 1 September 1989https://pubs.acs.org/doi/10.1021/ic00317a025https://doi.org/10.1021/ic00317a025research-articleACS PublicationsRequest reuse permissionsArticle Views82Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Regulated and aberrant glycosylation modulate cardiac electrical signaling (2009)

Millions afflicted with Chagas disease and other disorders of aberrant glycosylation suffer symptoms consistent with altered electrical signaling such as arrhythmias, decreased neuronal conduction velocity, and hyporeflexia. Cardiac, neuronal, and muscle electrical signaling is controlled and modulated by changes in voltage-gated ion channel activity that occur through physiological and pathological processes such as development, epilepsy, and cardiomyopathy. Glycans attached to ion channels alter channel activity through isoform-specific mechanisms. Here we show that regulated and aberrant glycosylation modulate cardiac ion channel activity and electrical signaling through a cell-specific mechanism. Data show that nearly half of 239 glycosylation-associated genes (glycogenes) were significantly differentially expressed among neonatal and adult atrial and ventricular myocytes. The N-glycan structures produced among cardiomyocyte types were markedly variable. Thus, the cardiac glycome, defined as the complete set of glycan structures produced in the heart, is remodeled. One glycogene, ST8sia2, a polysialyltransferase, is expressed only in the neonatal atrium. Cardiomyocyte electrical signaling was compared in control and ST8sia2((-/-)) neonatal atrial and ventricular myocytes. Action potential waveforms and gating of less sialylated voltage-gated Na+ channels were altered consistently in ST8sia2((-/-)) atrial myocytes. ST8sia2 expression had no effect on ventricular myocyte excitability. Thus, the regulated (between atrium and ventricle) and aberrant (knockout in the neonatal atrium) expression of a single glycogene was sufficient to modulate cardiomyocyte excitability. A mechanism is described by which cardiac function is controlled and modulated through physiological and pathological processes that involve regulated and aberrant glycosylation.
Microcolumn Separation Methods and Their Ancillary Techniques (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMicrocolumn Separation Methods and Their Ancillary TechniquesMilos NovotnyCite this: Anal. Chem. 1983, 55, 13, 1308A–1314APublication Date (Print):November 1, 1983Publication History Published online29 May 2012Published inissue 1 November 1983https://pubs.acs.org/doi/10.1021/ac00263a728https://doi.org/10.1021/ac00263a728research-articleACS PublicationsRequest reuse permissionsArticle Views33Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Functional characterization of six SLCO1B1 (OATP1B1) variants observed in Finnish individuals with a psychotic disorder (2022)

Abstract Aim Variants in the SLCO1B1 (solute carrier organic anion transporter family member 1B1) gene encoding the OATP1B1 (organic anion transporting polypeptide 1B1) protein are associated with altered transporter function that can predispose patients to adverse drug effects with statin treatment. We explored the effect of six rare SLCO1B1 single nucleotide variants (SNVs) occurring in Finnish individuals with a psychotic disorder on expression and functionality of the OATP1B1 protein. Methods The SUPER-Finland study has performed exome sequencing on 9,381 individuals with at least one psychotic episode during their lifetime. SLCO1B1 SNVs were annotated with PHRED-scaled Combined Annotation-Dependent (CADD) scores and the Ensembl variant effect predictor (VEP). In vitro functionality studies were conducted for the SNVs with PHRED-scaled CADD score &gt;10 and predicted to be missense. To estimate possible changes in transport activity caused by the variants, transport of 2’,7’-dichlorofluorescein (DCF) in OATP1B1 expressing HEK293 cells was measured. The amount of OATP1B1 in crude membrane fractions was quantified with a LC–MS/MS-based quantitative targeted absolute proteomics analysis. Results Six rare missense variants of SLCO1B1 were identified in the study population located in transmembrane helix 3: c.317T&gt;C (p.106I&gt;T), intracellular loop 2: c.629G&gt;T (p.210G&gt;V), c.633A&gt;G (p.211I&gt;M), c.639T&gt;A (p.213N&gt;L), transmembrane helix 6: 820A&gt;G (p.274I&gt;V), and the C-terminal end: 2005A&gt;C (p.669N&gt;H). Of these variants, SLCO1B1 c.629G&gt;T (p.210G&gt;V) resulted in protein loss of function, abolishing the uptake of DCF and reducing membrane protein expression to 31% of reference OATP1B1. Conclusions Of the six rare missense variants, SLCO1B1 c.629G&gt;T (p.210G&gt;V) causes loss-of-function of OATP1B1 transport and severely decreases membrane protein abundance. Carriers of SLCO1B1 c.629G&gt;T may be susceptible to altered pharmacokinetics of OATP1B1 substrate drugs and may have increased likelihood of adverse drug effects such as statin-associated musculoskeletal symptoms. Abstract Figure
The Science of Minimally Invasive Total Hip Arthroplasty (2007)

Minimally invasive hip surgery has stimulated a new process in hip arthroplasty. There is consensus among surgeons about the benefits of anesthesia, pain management, and rapid recovery protocols. The benefits of the surgical technique for small incision surgery remain controversial. Some patients influence this controversy because they prefer minimally invasive hip surgery: they associate less body violation and better cosmesis with smaller incisions. Small incision surgery is associated with a learning curve and requires specialized instruments for favorable outcomes. Despite being a more difficult operation to perform, in skilled hands it is a safe procedure that does not increase complication rates as shown by recent prospective, randomized studies. Correct component positioning has been achieved consistently with these procedures and short-term results of small incision surgery are the same as with long incisions. New anesthesia and pain management techniques have led to remarkable early functional results, making same-day surgery possible. With improved instrumentation such as computer navigation, minimally invasive total hip arthroplasty will become more prevalent.
Reconfigurable optical inter-channel interference compensation of 20/25-Gbaud QPSK signals using nonlinear wave mixing (2015)

A reconfigurable optical inter-channel interference compensation method without channel spacing estimation and relative time delay calibration is proposed for a high density multi-carrier transmission system. Experiments demonstrate the effectiveness for both 20/25-Gbaud dual-carrier QPSK systems with different channel spacing conditions.
100 GHz optical-to-radio converter module and its application in radio and power over fiber transmission through multi-core fiber (2017)

We developed a 100 GHz optical-to-radio converter module integrated with a 100 GHz amplifier, which was applied in radio (12-Gbps, OFDM, 16-QAM, IF = 92-GHz) and power over fiber transmission through a multi-core fiber.
Catheter Ablation of Ventricular Tachycardia: Role of the Underlying Etiology and the Site of Energy Delivery (1992)

The role of DC catheter ablation (CA) to treat patients with sustained monomorphic ventricular tachycardia (VT) is still debated. To assess the efficacy of VT CA, we studied the follow‐up of 49 patients with VT who underwent CA. There were 33 patients with an old myocardial infarction [MI] (group G I) and 16 patients had noncoronary VT (group G II): CA was performed at the earliest endocardial activation (EEA)(20 patients in G I, 14 patients in G II) or at the area of slow conduction (ASC) (13 patients in GI, 2 patients in GII). During the mean follow‐up of 35 ± 25 (1–79) months, there were 17 patients in G I (52%) and 12 patients in G II (75%) with VT recurrences (P &lt; 0.05). Recurrences of VT was observed in 4 of 15 patients (27%) when CA was performed at the ASC, compared to 25 of 34 patients (74%) with CA at the EEA (P &lt; 0.01). These data show that DC CA is more successful in patients with coronary artery disease, particularly when CA is performed at the ASC.
An Automated Grading System for Detection of Vision-Threatening Referable Diabetic Retinopathy on the Basis of Color Fundus Photographs (2018)

This artificial intelligence-based DLA can be used with high accuracy in the detection of vision-threatening referable DR in retinal images. This technology offers potential to increase the efficiency and accessibility of DR screening programs.
CO Oxidation and Site Speciation for Alloyed Palladium–Platinum Model Catalysts Studied by in Situ FTIR Spectroscopy (2017)

In situ Fourier transform infrared spectroscopy was used to study transient CO oxidation over a series of bimetallic Pd–Pt catalysts with different Pd:Pt molar ratios. The catalysts were found to contain both alloyed PdPt nanoparticles (particle sizes 25–35 nm) and monometallic Pd nanoparticles (sizes below 10 nm). For oxygen-free conditions, CO reduces the surface while simultaneously function as a chemical probe molecule whereby the CO adsorption sites can be characterized. Under these conditions, it is shown that adsorbed carbonyl species form both on the Pd and Pt. On platinum, CO adsorbs predominantly linearly on top, whereas on palladium it adsorbes in bridged configurations. This behavior is used for site speciation of the catalysts. The spectra from the bimetallic Pd–Pt catalysts are more complicated than a direct superposition of the spectra for the monometallic catalysts as a consequence of alloy formation and enrichment of Pd at the surface of the reduced catalysts. The temperature-programmed CO oxidation results show that the addition of Pd to the Pt catalyst supported on alumina shifts the CO-poisoned state to lower temperatures, therefore increasing the temperature range for the CO oxidation at low temperatures.
High T/sub c/ YBa/sub 2/Cu/sub 3/O/sub 7-x/ superconducting thin films by rf magnetron sputtering (1988)

Thin films of YBa/sub 2/Cu/sub 3/O/sub 7-x/ were deposited by RF magnetron sputtering onto BaTiO/sub 3/, Al/sub 2/O/sub 3/, MgO, and SrTiO/sub 3/ substrates at ambient temperature to 500/sup 0/C from a sintered powder target having the same nominal composition. Four point AC resistivity measurements indicate that these films (approx.2..mu..m thick) are superconducting after annealing in flowing oxygen at approx.900/sup 0/C for several minutes. While the onset T/sub c/ remains fairly constant at approx.88--91 K, the ending T/sub c/ depends strongly on the deposition and annealing conditions, and substrates used. The films deposited at 300/sup 0/C and annealed at 900/sup 0/C for 1min., for example, have an ending T/sub c/ of 45--53, 70--83, and 80--86.5 K when deposited, respectively, on Al/sub 2/O/sub 3/, BaTiO/sub 3/ and MgO, and SrTiO/sub 3/. Electron microprobe analyses show that these films have a spatially homogeneous composition of typically approx.YBa/sub 2/Cu/sub 3/O/sub 8/. X-ray diffraction data also reveal that the annealed films have the characteristics orthorhombic structure with lattice constants practically identical to those of the bulk YBa/sub 2/Cu/sub 3/O/sub 7-x/, although minor phases (e.g., BaCuO/sub 2/) with concentration of up to 15% can also be detected. These effects of ion bombardment during deposition andmore » of interdiffusion of film and substrate during annealing are also presented, with emphasis on the film composition and T/sub c/, and stability in room ambient.« less
A JWST Near- and Mid-Infrared Nebular Spectrum of the Type Ia Supernova 2021aefx (2022)

We present JWST near- and mid-infrared spectroscopic observations of the nearby normal Type Ia supernova SN 2021aefx in the nebular phase at $+255$ days past maximum light. Our Near Infrared Spectrograph (NIRSpec) and Mid Infrared Instrument (MIRI) observations, combined with ground-based optical data from the South African Large Telescope (SALT), constitute the first complete optical $+$ NIR $+$ MIR nebular SN Ia spectrum covering 0.3$-$14 $μ$m. This spectrum unveils the previously unobserved 2.5$-$5 $μ$m region, revealing strong nebular iron and stable nickel emission, indicative of high-density burning that can constrain the progenitor mass. The data show a significant improvement in sensitivity and resolution compared to previous Spitzer MIR data. We identify numerous NIR and MIR nebular emission lines from iron-group elements and as well as lines from the intermediate-mass element argon. The argon lines extend to higher velocities than the iron-group elements, suggesting stratified ejecta that are a hallmark of delayed-detonation or double-detonation SN Ia models. We present fits to simple geometric line profiles to features beyond 1.2 $μ$m and find that most lines are consistent with Gaussian or spherical emission distributions, while the [Ar III] 8.99 $μ$m line has a distinctively flat-topped profile indicating a thick spherical shell of emission. Using our line profile fits, we investigate the emissivity structure of SN 2021aefx and measure kinematic properties. Continued observations of SN 2021aefx and other SNe Ia with JWST will be transformative to the study of SN Ia composition, ionization structure, density, and temperature, and will provide important constraints on SN Ia progenitor and explosion models.
Vinylidene transition-metal complexes. Part 13. The reactivity of [IrH5(PPri3)2] and [IrH2Cl(PPri3)2] toward Alk-1-ynes: synthesis of four-, five- and six-co-ordinate iridium complexes containing alkynyl, vinyl and vinylidene ligands (1991)

Reaction of [IrH5(PPri3)2]2 with excess of phenylacetylene in pentane gives the tris(alkynyl) complex [Ir(C2Ph)3(PPri3)2]3, whereas with acetylene and propyne the bis(alkynyl) vinyl compounds [Ir(C2R)2(CRCH2)(PPri3)2](R = H, 4; or Me 5) are obtained. Complexes 3–5 react smoothly with H2 to give 2 and the corresponding alkene and thus are supposed to be intermediates in the hydrogenation of alk-1-ynes catalysed by 2. Reaction of [IrH2Cl(PPri3)2]8 with PhC2H occurs stepwise leading to the formation of the mono-, bis- and tris-(alkynyl) iridium(III) derivatives [IrH(Cl)(C2Ph)(PPri3)2]9, [IrCl(C2Ph)2(PPri3)2]10 and 3. From 8 and acetylene, the vinylidene complex [IrCl(CCH2)(PPri3)2]11 is obtained. Treatment of 8 with an equimolar amount of HC2CO2Me gives first the alkynyl hydrido compound [IrH(Cl)(C2CO2Me)(PPri3)2]12 which on warming to 80 °C in benzene rearranges to give the substituted vinylidene isomer [IrCl(CCHCO2Me)(PPri3)2]13 in virtually quantitative yield. The reaction of 8 with 2 equivalents of HC2CO2Me leads to the formation of the bis(alkynyl) complex [IrCl(C2CO2Me)2(PPri3)2]14.
A new carbon–carbon bond forming reaction using O-methyl (S)-prop-2-ynyl dithiocarbonate (1996)

M. Poelert, W. Roger and S. Z. Zard, Chem. Commun., 1996, 743 DOI: 10.1039/CC9960000743
An investigation on the cutoff characteristics of sub-quarter-micron SOI MOSFET (1991)

The influence of DIBL on the latch condition for subquarter-micron SOI (silicon-on-insulator) MOSFETs is investigated. It is found that the main effect of DIBL is lowering the minimum hole current for latch. Simulated results on device structures proposed to improve cutoff characteristics are also shown. The cutoff characteristics of an SOI MOSFET (L=0.2 mu m) for which higher acceptor concentration (Na=2*10/sup 17/ cm/sup -3/) SOI film and LDD (lightly doped drain) structure are adopted are shown. These design options are effective for reducing DIBL at the SOI bottom.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Impacts of magnesium ions on the unzipping of λ-phage DNA (2006)

We used magnetic tweezers to exert a constant force to separate double stranded λ-phage DNA as a function of temperature and buffer content. The separation was performed at temperatures ranging from 20 to 50 °C in various Mg2+ buffers, including a T4 ligase buffer and a PCR buffer. At 30 °C and pH 7.4 (10 mM Tris), we measured the unzipping force as a function of concentration for Mg2+ concentrations between 0.2 and 50 mM, and determined that the unzipping force is proportional to the logarithm of concentration. For comparison, we performed the analogous experiment as a function of Na+ concentration and found that the unzipping force is also proportional to the log of concentration, but requires a much higher cation concentration to achieve the same unzipping force as in Mg2+ buffer. We also constructed the phase diagram in the force–temperature plane for the unzipping in 10 and 50 mM MgCl2 at pH 7.4 (10 mM Tris). The phase diagram for 10 mM Mg2+ is similar to the one measured previously for phosphate buffer saline (PBS) but the phase diagram for 50 mM Mg2+ deviates significantly from those for 10 mM Mg2+ and PBS at temperatures between 20 and 35 °C.
Application of MR-guided focused pulsed ultrasound for destroying clots in vitro using thrombolytic drugs (2011)

In this paper an MR‐guided focused pulsed ultrasound system for the treatment of stroke using thrombolytic drugs in a model in vitro is presented. A single element spherically focused transducer of 5 cm diameter; focusing at 10 cm and operating at 0.5 MHz or 1 MHz was used. The transducer was mounted in an MR compatible robot. The artery was modelled using a silicone tube. Tissue was modelled using polyaclylimide gel. Coagulated blood was used to model thrombus. A thermocouple was placed in the thrombus in order to measure the thrombus temperature. The effect of power, beam, and frequency was investigated. The goal was to maintain a temperature increase of less than 1 °C during the application of pulse ultrasound (called safe temperature). With the application of ultrasound alone there was no notable destruction of the thrombus. With the combination of ultrasound and thrombolytic drugs destruction occurred after 60 mins of pulse exposure (PRF = 1 s, duty factor = 10%, and with thrombus placed at 1 cm deep in the tissue). This simple in vitro model was proven very successful for evaluating MRgFUS as a modality for treating stroke. In the future we plan to apply this treatment protocol in live animals and humans.
Phase reorganization leads to transient β-LFP spatial wave patterns in motor cortex during steady-state movement preparation (2018)

Previous studies on the origin and properties of spatial patterns in motor cortex β-local field potential (β-LFP) oscillations have focused on planar traveling waves. However, it is unclear 1) whether β-LFP waves are limited to plane waves, or even 2) whether they are propagating waves of excito-excitatory activity, i.e., primarily traveling waves in excitable media; they could reflect, instead, reorganization in the relative phases of transient oscillations at different spatial sites. We addressed these two problems in β-LFPs recorded via microelectrode arrays implanted in three adjacent motor cortex areas of nonhuman primates during steady-state movement preparation. Our findings are fourfold: 1) β-LFP wave patterns emerged as transient events, despite stable firing rates of single neurons concurrently recorded during the same periods. 2) β-LFP waves showed a richer variety of spatial dynamics, including rotating and complex waves. 3) β-LFP wave patterns showed no characteristic wavelength, presenting instead a range of scales with global zero-lag phase synchrony as a limiting case, features surprising for purely excito-excitatory waves but consistent with waves in coupled oscillator systems. 4) Furthermore, excito-excitatory traveling waves induced by optogenetic stimulation in motor cortex showed, in contrast, a characteristic wavelength and reduced phase synchrony. Overall, β-LFP wave statistics differed from those of induced traveling waves in excitable media recorded under the same microelectrode array setup. Our findings suggest phase reorganization in neural coupled oscillators contribute significantly to the origin of transient β-LFP spatial dynamics during preparatory steady states and outline important constraints for spatially extended models of β-LFP dynamics in motor cortex. NEW & NOTEWORTHY We show that a rich variety of transient β-local field potential (β-LFP) wave patterns emerge in motor cortex during preparatory steady states, despite stable neuronal firing rates. Furthermore, unlike optogenetically induced traveling waves, β-LFP waves showed no characteristic wavelength, presenting instead a range of scales with global phase synchrony as a limiting case. Overall, our statistical analyses suggest that transient phase reorganization in neural coupled oscillators, beyond purely excito-excitatory traveling waves, contribute significantly to the origin of motor cortex β-LFP wave patterns.