gebhart/patrepeval huggingface dataset:
AdKDD 2023 (2023)

The digital advertising field has always had challenging ML problems, learning from petabytes of data that is highly imbalanced, reactivity times in the milliseconds, and more recently compounded with the complex user's path to purchase across devices, across platforms, and even online/real-world behavior. The AdKDD workshop continues to be a forum for researchers in advertising, during and after KDD. Our website which hosts slides and abstracts receives approximately 2,000 monthly visits and 1,800 active users during the KDD 2021. In surveys during AdKDD 2019 and 2020, over 60% agreed that AdKDD is the reason they attended KDD, and over 90% indicated they would attend next year. The 2023 edition is particularly timely because of the increasing application of Graph-based NN and Generative AI models in advertising. Coupled with privacy-preserving initiatives enforced by GDPR, CCPA the future of computational advertising is at an interesting crossroads. For this edition, we plan to solicit papers that span the spectrum of deep user understanding while remaining privacy-preserving. In addition, we will seek papers that discuss fairness in the context of advertising, to what extent does hyper-personalization work, and whether the ad industry as a whole needs to think through more effective business models such as incrementality. We have hosted several academic and industry luminaries as keynote speakers and have found our invited speaker series hosting expert practitioners to be an audience favorite. We will continue fielding a diverse set of keynote speakers and invited talks for this edition as well. As with past editions, we hope to motivate researchers in this space to think not only about the ML aspects but also to spark conversations about the societal impact of online advertising.
Electrophoretic resolution of monosaccharide enantiomers in borate-oligosaccharide complexation media (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectrophoretic resolution of monosaccharide enantiomers in borate-oligosaccharide complexation mediaMorgan Stefansson and Milos NovotnyCite this: J. Am. Chem. Soc. 1993, 115, 24, 11573–11580Publication Date (Print):December 1, 1993Publication History Published online1 May 2002Published inissue 1 December 1993https://doi.org/10.1021/ja00077a064RIGHTS & PERMISSIONSArticle Views345Altmetric-Citations97LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (773 KB) Get e-Alerts Get e-Alerts
Sutureless Triplanar Sclerotomy for 23-Gauge Vitrectomy (2011)

It is possible to achieve high rates of unsutured wound closure with triplanar transscleral sclerotomies. No single method of evaluating wound leakage appeared to be the most sensitive. More complex cases requiring longer surgical times, more instrument passes, and increased wound manipulation resulted in higher rates of wound leakage. Leakage can be subtle, and surgeons should use multiple methods to adequately assess sclerotomy closure.
OP02 Ustekinumab versus adalimumab for induction and maintenance therapy in Moderate-to-Severe Crohn’s Disease: The SEAVUE study (2021)

Abstract Background We studied the efficacy and safety of ustekinumab (UST) vs adalimumab (ADA) through 1 year in biologic-naïve patients (pts) with moderate-to-severe Crohn’s disease. Methods SEAVUE was a multicenter, randomized, blinded, parallel-group, active-controlled study in adults with CD Activity Index (CDAI) scores ≥220/≤450. Biologic-naïve pts failing/intolerant to conventional therapy with any size ulcer on baseline (BL) ileocolonoscopy were eligible. Pts were randomized 1:1 to UST (⁓6mg/kg IV at BL then 90mg SC every 8 weeks [Ws]) or ADA (160/80mg SC at BL/W2, then 40mg SC every 2 Ws) per US-approved regimens (no dose modifications). Primary endpoint was clinical remission at W52 (CDAI &amp;lt;150). Major secondary endpoints were corticosteroid-free remission, clinical response (≥100-point CDAI decrease from BL), remission in pt-reported CDAI components (PRO-2 symptom remission: abdominal pain mean daily score ≤1 and stool frequency mean daily score ≤3), and endoscopic remission (SES-CD score ≤3/0 for pts with BL score=3) at W52 and clinical remission at W16. Results 386 pts were randomized to UST or ADA. BL demographics and disease characteristics were balanced between groups and indicative of pts with early, moderate-to-severe CD (median CD duration, 2.58 years; CDAI, 289.5; SES-CD, 8.0). At W52, 65% of UST-treated and 61% of ADA-treated pts achieved clinical remission (Δ=4.0%; 95% CI, -5.5%, 13.5%; p=0.417). Major secondary endpoints, including endoscopic remission, were similar between groups (Table 1), as were remission rates at assessment points through W52. Some other secondary endpoints showed numerical (not statistical) differences between UST and ADA (Table 1). Key safety events are summarized in Table 2. Among UST-treated and ADA-treated pts, 34.0% and 40.5% had infections, 2.6% and 7.2% had serious adverse events (AEs) of worsening CD, and 6.3% and 11.3% had AEs that led to discontinuation (DC) of study drug, respectively. One ADA-treated pt had active pulmonary TB. Injection-site reactions associated with active treatment occurred in 1.0% of UST-treated and 10.3% of ADA-treated pts. Overall, 15.2% of UST-treated and 23.6% of ADA-treated pts DC before W52. Reasons for DC were primarily lack of efficacy (UST, 2.1% vs ADA, 5.1%), AEs (UST, 5.7% vs ADA, 10.7%), and withdrawal of consent (UST, 5.8% vs ADA, 5.1%). Time to treatment DC was longer with UST vs ADA (post hoc analysis). Conclusion Both UST and ADA were highly effective in this population of biologic-naïve pts. Rates of clinical remission at W52 were not statistically significantly different between treatment groups. DC rates were numerically lower for UST. Safety results were consistent with prior experience for both treatments.
Dammarane Triterpenes from Gardenia aubryiVieill. (2011)

Abstract Three new dammarane triterpenoids, gardaubryones A–C ( 1 – 3 ), were isolated from the gum collected on the aerial parts of Gardenia aubryi Vieill ., together with the known compounds hydroxydammarenone II ( 4 ), ocotillone ( 5 ), cabraleone, and hollongdione. The structures of the novel compounds were established on the basis of mass spectrometry, NMR experiments, and chemical‐correlation reactions.
Superprism phenomenon in three-dimensional macroporous polymer photonic crystals (2003)

The superprism phenomenon is the extremely large angular dispersion experienced by a light beam when entering a photonic crystal. This arises from the anisotropy of the photonic band structure. Strong anisotropy can be present even in systems without a complete photonic band gap. Here, we describe a theoretical investigation of the superprism effect in three-dimensional macroporous polymer photonic crystals formed from colloidal crystal templates. From the complete photonic band structure, an equal-energy surface (dispersion surface) is obtained. The propagation direction inside the photonic crystal is determined by the gradient of this surface. Using this formalism, we explore the extreme sensitivity of the propagation direction to various input parameters, including the input angle, the light frequency, and the composition of the photonic lattice. Such effects can be exploited for sensing and filtering applications.
EP3/FP dual receptor agonist ONO-9054 administered morning or evening to patients with open-angle glaucoma or ocular hypertension: results of a randomised crossover study (2015)

NCT01670266.
How To Measure Work of Adhesion and Surface Tension of Soft Polymeric Materials (2018)

Knowledge of the work of adhesion and surface tension directs the design of new materials for coatings, adhesives, and lubricants. We develop an approach to determine both properties from analysis of equilibrium indentations of rigid particles in contact with soft polymeric materials. In accord with coarse-grained molecular dynamics simulations, the indentation depth is described by the crossover expression combining together the adhesion and wetting models, which takes into account both the elastic energy of the contact and full surface free energy change outside and inside the contact area. The crossover expression is applied to obtain the work of adhesion and substrate surface tension for polystyrene (PS), carboxyl-modified polystyrene (PS-COOH), and poly(methyl methacrylate) (PMMA) particles in contact with poly(dimethylsiloxane) (PDMS) networks made of brush-like and linear chains. This analysis results in the work of adhesion W = 48.0 ± 2.9 mN/m for PS/PDMS, W = 268.4 ± 27.0 mN/m for PS-COOH/PDMS, and W = 56.2 ± 2.4 mN/m for PMMA/PDMS and the surface tension of the PDMS substrate to be γs = 23.6 ± 2.1 mN/m.
Convenient Synthesis of Novel Phenylpyrimido[1,2-c]thienopyrimidinones as IL-6/STAT3 Inhibitors (2015)

New phenylpyrimido[1,2-c]thienopyrimidinones 4A and 4B were easily prepared in good yields by the one-pot reaction of formamidine derivatives 2 of 4-aminothienopyrimidine 1 with phenylacetyl chlorides. The application of this convenient and reliable method could be used for the synthesis of a variety of pyrimido[1,2-c]thienopyrimidinone derivatives of biological importance. Some of the compounds synthesized showed strong IL-6/STAT3 inhibition.
Rational Design and Theoretical Optimization of a Cryopreservation Protocol (1995)

Abstract A cryopreservation protocol for mouse oocytes was developed by rational design and theoretical optimization using a physicochemical model of the intracellular ice formation process. Theoretical models of freeze-induced cell dehydration, homogeneous and heterogeneous nucleation of intracellular ice, and diffusion-limited crystal growth of intracellular ice were coupled and solved numerically to obtain predictions of cell response to freezing. A two-step, piecewise linear cooling protocol was chosen based on simulation results, and protocol parameters were then optimized using the mathematical model. The predicted optimal parameters were an initial cooling rate of Bdehydration = 0.59°C/min and a plunge temperature of Tplunge = −67°C. Experimental testing showed that optimal survival (78% cells morphologically normal) was obtained at Bdehydration = 0.5°C/min and Tplunge = −80°C. The fertilization rate and blastocyst formation rate of oocytes cryopreserved using the optimized protocol were 65% and 49%, respectively.
PLATELET-DEPENDENT GENERATION OF CHEMOTACTIC ACTIVITY IN SERUM (1973)

A protein fraction extracted from the lysosomal granules of human platelets generated chemotactic activity for polymorphonuclear leukocytes when incubated with fresh serum. The platelet factor was also released during platelet aggregation with collagen or epinephrine and appeared to be released during blood clotting. Heated serum did not support the platelet-dependent generation of chemotactic activity. Treatment of fresh serum with antibody to the fifth component of complement also prevented development of activity. Purified human C5 but not C3 yielded chemotactic activity upon incubation with the platelet factor. Thus, human platelets are capable of stimulating chemotaxis via complement activation in a manner similar to leukocytes, and may therefore participate in the early stages of inflammation.
All-optical frequency division on-chip using a single laser (2023)

The generation of spectrally pure high-frequency microwave signals is a critical functionality in fundamental and applied sciences, including metrology and communications. The development of optical frequency combs has enabled the powerful technique of optical frequency division (OFD) to produce microwave oscillations of the highest quality. The approaches for OFD demonstrated to date demand multiple lasers with space- and energy-consuming optical stabilization and electronic feedback components, resulting in device footprints incompatible with integration into a compact and robust photonic platform. Here, we demonstrate all-optical OFD on a single photonic chip driven with a single continuous-wave laser. We generate a dual-point frequency reference using the beat frequency of the signal and idler fields from a microresonator-based optical parametric oscillator (OPO), which achieves high phase stability due to the inherently strong signal-idler frequency correlations. We implement OFD by optically injecting the signal and idler fields from the OPO to a Kerr-comb microresonator on the same chip. We show that the two distinct dynamical states of Kerr cavities can be passively synchronized, allowing broadband frequency locking of the comb state, which transfers the stability of the OPO frequencies to the repetition rate of the Kerr comb. A 630-fold phase-noise reduction is observed when the Kerr comb is synchronized to the OPO, which represents the lowest noise generated on the silicon-nitride platform. Our work demonstrates a simple, effective approach for performing OFD and provides a pathway toward chip-scale devices that can generate microwave frequencies comparable to the purest tones produced in metrological laboratories. This technology can significantly boost the further development of data communications and microwave sensing.
365-OR: Interruption of Glucagon Signaling Increases Delta-Cell Proliferation in Mouse and Human Islets (2022)

The determinants of delta cell mass are not known. As part of studies showing interruption of glucagon signaling (IGS) stimulates alpha cell proliferation in an amino acid (AA) -dependent manner, we noted an increase in delta cells. To investigate, we examined delta cell proliferation and mass in 3 mouse models and a human islet xenograft model. Adult mice with deletion of glucagon (Gcg-/- ) had a 4.7-fold increase in Ki67-positive delta cells (1.50±0.14% vs. 0.32±0.12%, P&amp;lt;0.001, n=8) and a 3.1-fold increase in delta cell mass (0.49±0.vs. 0.16±0.mg, P=0.003, n=10) . Treatment of adult C57BL/6J mice with a Gcg receptor antibody (GCGR Ab) elicited a 6.3-fold increase in delta cell proliferation (2.01±0.4% vs. 0.32±0.07%, P=0.002, n=10) and a 2.6-fold increase in delta cell mass (0.20±0.03 vs. 0.078±0.mg, P=0.001, n=10) , respectively, compared to IgG-treated controls. Since hyperaminoacidemia is necessary for alpha cell proliferation in response to IGS, we investigated the requirement for Slc7a2, a cationic AA transporter, in delta cell growth. Indeed, Slc7a2+/+ mice, but not Slc7a2-/- mice, treated with GCGR Ab had a 3.8-fold increase in delta cell proliferation (3.29±0.14% vs. 0.86±0.05%, P&amp;lt;0.001) and 1.6-fold increase in delta cell mass (0.20±0.02 vs. 0.126±0.mg, P=0.016, n=8) . Given that mTOR is a known intracellular mediator of AA-regulated cellular growth, we evaluated phospho-ribosomal protein S6 (pS6) expression in situ and found a marked increase in pS6 labeling of delta cells in Gcg-/- , but not Gcg+/+ , mice. We also observed a 3.6-fold increase in delta cell proliferation (1.75±0.25% vs. 0.49±0.06%, P=0.004, n=3 adult normal donors) in human islets transplanted into immunodeficient mice treated with GCGR Ab. Taken together, these data indicate that IGS promotes delta cell proliferation and mass through mechanisms involving Slc7a2 and the mTOR signaling pathway and that AAs may be a determinant of delta cell mass. Disclosure C.Dai: None. A.Bradley: None. E.Spears: None. A.K.Singh: None. F.O.Oladipupo: None. R.Jenkins: None. K.C.Coate: None. A.C.Powers: None.
<title>Number Theoretic Processors, Optical And Electronic</title> (1979)

An inner product processor is presented which is capable of performing 3.3 million inner products a second, where each vector consists of 100 elements each 20 bits wide. This is equivalent to more than 660 million 40 bit arithmetic operations a second. The latency of a particular calculation is 12.3 microseconds. The processor can be constructed entirely from 1024 by 6 bit ROMs with 300 ns cycle times and latchable inputs or outputs. Modular arithmetic is used internally; the input and output are binary. The specifications of the architecture are compatible with the stricter structural requirements needed by an optical implementation.
Speed and acceleration controllers for a light electric two-wheeled vehicle (2011)

Environmental concerns and the steadily decreasing oil supplies have promoted a significant interest in electric vehicles (EVs) as a solution for the mobility of the near future, especially in urban environments. The correct handling of the energy behavior on board is one of the most critical problems to be addressed, particularly in urban driving scenarios where the speed profiles - even on fixed routes - are a priori unknown since they are affected by significant unpredictable external factors. The high-level control of the energy flows requires an accurate knowledge of the vehicle dynamics, as speed and acceleration directly affect the battery power. To cope with these issues, this paper addresses the modeling and identification of the longitudinal dynamics of an electric two-wheeled vehicle, based on which a model-based motion control strategy is designed. The controller goal is to confine speed and accelerations within desired bounds while guaranteeing a good driving feeling. The approach is experimentally validated on an instrumented light electric two-wheeled vehicle.
Abstract P3033: Sodium Induced Dopamine D1 Receptor (D1R) Plasma Membrane Recruitment Involves Protein Phosphatase 2a (PP2A) and Aminopeptidase N (APN) (2019)

The cooperative relationship between the dopamine type 1 receptor (D 1 R) and the angiotensin type 2 receptor (AT 2 R) signaling pathway in renal proximal tubule cells (RPTCs) is known as a significant mediator of natriuresis and systemic sodium (Na + ) homeostasis. The degree of Na+ induced D 1 R plasma membrane recruitment correlates with the degree of salt sensitivity of blood pressure in urine-derived RPTCs collected from clinical study participants. We recently published that the Protein Phosphatase 2A (PP2A) pathway is a common and necessary pathway for D 1 R and AT 2 R cooperativity and function. Here, we extend these studies by examining the autocrine signaling in previously published model RPTCs that are normally D 1 R cAMP coupled (i22) and D 1 R cAMP uncoupled (i19). D 1 R and aminopeptidase N (APN) plasma membrane expression was measured by flow cytometry, and an elevated NaCl solution (PBS + 50 mM NaCl, 1 hour) was used for increased salt exposure. The addition of FTY720 (2.5 μM, 1 hour) activated PP2A. Normally coupled i22 cells in the presence of increased Na + significantly increase plasma membrane D 1 R (1.41±0.10 fold vs VEH, n=3 p&lt;0.05), but uncoupled i19 cells did not. FTY720 alone did not significantly increase plasma membrane D 1 R in uncoupled i19 cells; however, FTY720 along with increased Na + did significantly increase i19 plasma membrane D 1 R (1.61±0.17 fold vs VEH, n=9 p&lt;0.001). In order to inhibit local production of dopamine, BCH (2-aminobicyclo(2,2,1)-heptane2-carboxylic acid, 1 mM), a LAT2 inhibitor, and Carbidopa (100 μM), a dopamine decarboxylase inhibitor, were used and completely blocked the plasma membrane recruitment of D 1 R. We next looked at enzymes involved in the regulation of AngIII peptide, the preferred agonist of the AT 2 R. APN is the enzyme that converts AngIII to AngIV. Under elevated Na + conditions levels of APN significantly decreased in normally coupled i22 but not in the uncoupled i19 cells (-7.3 ±0.01% vs VEH, n=6 p&lt;0.01). In summary, the data presented suggests that PP2A and enzymes involved in the local production of dopamine and AngIII, may be involved in the Na+ induced plasma membrane recruitment of D 1 R.
Kinetic Parameters of the Initiator Decomposition in Microwave and in Conventional Batch Reactors – KPS and V50‐Case Studies (2015)

Different values of the kinetic rate constants have been reported for initiator decompositions carried out in microwave and conventional batch reactors. The present work analyzes the confidence regions of kinetic parameters estimated for the thermal decomposition of two initiators, potassium persulfate (KPS) and 2‐2′‐azobis(2‐methylpropionamidine) dihydrochloride (V‐50), which confirm the difference between the parameters obtained in microwave and conventional reactors. Moreover, by assuming no changes in kinetics under microwave heating, the temperature and volume of hot spots required to explain the apparent increase of kinetic rate constants are calculated. The results suggest that formation of hot spots may explain the observed effects without the occurrence of additional phenomena.
Capillary electrophoretic and micellar electrokinetic separations of asymmetric dimethyl‐L‐arginine and structurally related amino acids: Quantitation in human plasma (2004)

We report the development of efficient electrophoretic methods for the separation and quantification of L-arginine and six naturally occurring derivatives that are structurally and functionally related. Capillary electrophoresis (CE) employing a concentrated borate buffer at pH 9.4 achieves the separation of mixtures containing dimethyl-L-arginine, NG-monomethyl-L-arginine, L-arginine, L-homoarginine, L-ornithine, and L-citrulline as 4-fluoro-7-nitrobenzofurazan derivatives. In addition, the separation of the isomeric dimethyl-L-arginine derivatives (symmetric and asymmetric) is attained with baseline resolution by micellar electrokinetic chromatography (MEKC) when a high concentration of deoxycholic acid is added as a surfactant to the same running buffer. The influence of buffer type, concentration, and pH on the separation was studied to optimize separation conditions. The limit of quantitation (LOQ) for asymmetric dimethyl-L-arginine in aqueous solution was determined to be 20 microM using UV absorption in a CE separation and 0.1 microM using laser induced fluorescence (LIF) detection in an MEKC separation. This newly developed method was successfully applied for the quantitation of asymmetric dimethyl-L-arginine and L-arginine in human plasma samples at levels that might be used as a clinical diagnostic for cardiovascular disease (0.125 microM LOQ).