gebhart/patrepeval huggingface dataset:
Cabergoline in the Treatment of Hyperprolactinemia: A Study in 455 Patients (1999)

Cabergoline is a new long-acting dopamine agonist that is very effective and well tolerated in patients with pathological hyperprolactinemia. The aim of this study was to examine, in a very large number of hyperprolactinemic patients, the ability to normalize PRL levels with cabergoline, to determine the effective dose and tolerance, and to assess the effect on clinical symptoms, tumor shrinkage, and visual field abnormalities. We also evaluated the effects of cabergoline in a large subgroup of patients with bromocriptine intolerance or -resistance. We retrospectively reviewed the files of 455 patients (102 males and 353 females) with pathological hyperprolactinemia treated with cabergoline in 9 Belgian centers. Among these patients, 41% had a microadenoma; 42%, a macroadenoma; 16%, idiopathic hyperprolactinemia; and 1%, an empty sella. The median pretreatment serum PRL level was 124 microg/L (range, 16-26,250 microg/L). A subgroup of 292 patients had previously been treated with bromocriptine, of which 140 showed bromocriptine intolerance and 58 showed bromocriptine resistance. Treatment with cabergoline normalized serum PRL levels in 86% of all patients: in 92% of 244 patients with idiopathic hyperprolactinemia or a microprolactinoma and in 77% of 181 macroadenomas. Pretreatment visual field abnormalities normalized in 70% of patients, and tumor shrinkage was seen in 67% of cases. Side effects were noted in 13% of patients, but only 3.9% discontinued therapy because of side effects. The median dose of cabergoline at the start of therapy was 1.0 mg/week but could be reduced to 0.5 mg/week once control was achieved. Patients with a macroprolactinoma needed a higher median cabergoline dose, compared with those with idiopathic hyperprolactinemia or a microprolactinoma: 1.0 mg/week vs. 0.5 mg/week, although a large overlap existed between these groups. Twenty-seven women treated with cabergoline became pregnant, and 25 delivered a healthy child. One patient had an intended abortion and another a miscarriage. In the patients with bromocriptine intolerance, normalization of PRL was reached in 84% of cases, whereas in the bromocriptine-resistant patients, PRL could be normalized in 70%. We confirmed, in a large-scale retrospective study, the high efficacy and tolerability of cabergoline in the treatment of pathological hyperprolactinemia, leaving few patients with unacceptable side effects or inadequate clinical response. Patients with idiopathic hyperprolactinemia or a microprolactinoma, on average, needed only half the dose of cabergoline as those with macroprolactinomas and have a higher chance of obtaining PRL normalization. Cabergoline also normalized PRL in the majority of patients with known bromocriptine intolerance or -resistance. Once PRL secretion was adequately controlled, the dose of cabergoline could often be significantly decreased, which further reduced costs of therapy.
ChemInform Abstract: REARRANGEMENTS OF ACYLOXYFURANS AND THIOPHENES (1978)

Abstract Acrylester (III) reagiert mit dem Furan (II) thermisch unter Addition zu (I).
Don't ask, don't tell: It's time to talk about complementary, alternative, and integrative medicine with our patients (2020)

Oncologists need to discuss the use of complementary, alternative, and integrative medicine with patients. Education concerning the topic needs to occur at all levels of medical professionals, starting with medical school.
Additive Manufacturing of Porous Metal (2017)

Currently, helium is obtained through separation from natural gas. The current industrial process incurs significant costs and requires large energy resources to successfully achieve separation. Through utilizing Additive Manufacturing (AM) technologies it is possible to reduce both of these burdens when refining helium gas. The ability to engineer porosity levels within Inconel 718 discs for controlled separation of helium from natural gas was investigated. Arrays of samples fabricated using the electron beam melting process were analyzed for their relative porosity density. Based upon the measurements, full scale discs were fabricated, and subsequently tested to determine their effectiveness in separating helium from liquefied natural gas.
Personal Agents on the Semantic Web (2003)

Personal assistants gather and filter relevant information and compose it into a coherent picture with regard to the user’s preferences. An intrinsic and important prerequisite for a personal assistant or rather any agent is to manipulate information avail- able on the Semantic Web in the form of ontologies, axioms, and rules written in various semantic markup languages. ;the means of information gathering being centralized (event notification services) or decentralized (peer agents). In this paper, a model architecture for such a personal assistant, that deals with real-world semantic markup is described.
Invited paper: Ultra-low energy security circuit primitives for IoT platforms (2017)

Low-area energy-efficient security primitives are key building blocks for enabling end-to-end content protection, user authentication in IoT platforms. This paper describes 3 designs that employ energy-efficient circuit techniques with optimal hardware-friendly arithmetic for seamless integration into area/battery constrained IoT systems: 1) A 2040-gate AES accelerator achieving 289Gbps/W efficiency in 22nm CMOS, 2) Hardened hybrid Physically Unclonable Function (PUF) circuit to generate a 100% stable encryption key. 3) All-digital TRNG to achieve >0.99 min-entropy with 3pJ/bit energy-efficiency.
Focal Erythrocyte Membrane Perturbations Caused by Nitroxide Lipid Analogues (1974)

Three classes of lipoidal nitroxide spin probes reversibly perturb erythrocyte membranes at low concentrations (10 -10 -10 -5 M). This is manifest in ( a ) decreased osmotic fragility and ( b ) alterations of surface topology. At bulk phase nitroxide concentrations providing maximal osmotic stabilization, the erythrocytes exhibit a classic echinocyte morphology. At nitroxide concentrations very slightly higher than those yielding minimal osmotic fragility (10 -5 -10 -4 M), the cellus undergo a sphering reaction and lyse. The morphologic sequence seen in intact cells is not observed in erythrocyte ghosts. We suggest that the spin probes initially concentrate in focal domains, which expand into echinocytic protrusions primarily due to localized weakening of membrane cohesion. We propose that cell lysis involves an irreversible breakdown in membrane domain structure.
Logarithmic moduli of roots of line bundles on curves (2022)

We use the theory of logarithmic line bundles to construct compactifications of spaces of roots of a line bundle on a family of curves, generalising work of a number of authors. This runs via a study of the torsion in the tropical and logarithmic jacobians (recently constructed by Molcho and Wise). Our moduli space carries a `double ramification cycle' measuring the locus where the given root is isomorphic to the trivial bundle, and we give a tautological formula for this class in the language of piecewise polynomial functions (as recently developed by Molcho-Pandharipande-Schmitt and Holmes-Schwarz).
LISP Explicit Locator Path (ELP) Probing (2018)

This document describes a LISP-TE mechanism to probe an Explicit
Locator Path (ELP) for reachability and telemetry data. The mechanism
is called ELP-Probing.
Internal Regularity of D-Glyceraldehide-3-Phosphate Dehydrogenase Genes and Proteins (2011)

Internal Regularity of D -Glyceraldehide-3-Phosphate Dehydrogenase Genes and Proteins Data of analysis of some GAPDH family gene exon and intron length (nt) and intron position coordinates as a sum of preceeding exon dimensions) and their internal regularity were analyzed based on a working hypothesis that primieval gene precursors were regular and periodic polynucleotides formed from oligonucleotides identical in size. The number of nucleotides in a gene repeat unit was denoted by a specific term - gene quantum and symbol Q . The following genes were analyzed: the chicken GAPDH (12 exons/11 introns) gene, the Chlamidomonas reinhardtii gapA (6 exons, 5 introns) and gapC (7 exons, 6 introns) genes. The determined value of Q for all these genes was identical and constituted 9 nucleotides. The sum total of all above-mentioned gene intron dimensions, independently of intron number in a gene, could be precisely quantized - expressed as a product of a gene quantum and a whole number, e.g., for the chicken GAPDH 1628 nt = 9 nt x 292,0. The garden pea Pissum sativum fragment (amino acids 167-219) was partially regular (the repeat unit size 9 aa) and showed translational symmetry. The obtained data supported the model that the precursors of the modern genes were originated by nucleotide multiplication reactions.
Processability, morphology and mechanical properties of wood flour reinforced high density polyethylene composites (2003)

AbstractAbstractWood flour reinforced high density polyethylene (HDPE) composites have been prepared and their rheological properties measured. The melt viscosity decreased as the processing temperature increased and the wood flour content decreased. A power law model was used to describe the pseudoplasticity of these melts. Adding wood flour to HDPE produced an increase in tensile strength and modulus. Composites compounded in a twin screw extruder and treated with a coupling agent (vinyltrimethoxysilane) or a compatibliser (HDPE grafted with maleic anhydride) exhibited better mechanical properties than the corresponding unmodified composites because of improved dispersion and good adhesion between the wood fibre and the polyalkene matrix. Scanning electron microscopy of the fracture surfaces of these composites showed that both the coupling agent and compatibiliser gave superior interfacial strength between the wood fibre and the polyalkene matrix.
Mechanisms Responsible for Cardiac Energetic Impairment in Type 1 Diabetes (2009)

Background Heart failure occurs frequently in individuals with diabetes and is commonly caused by epicardial coronary artery disease (CAD) and/or hypertension. However, in some patients left ventricular dysfunction occurs in the absence of significant epicardial CAD or hypertension. Asymptomatic individuals with diabetes have impaired cardiac energetic status, as reflected in a reduced phosphocreatine/beta adenosine triphosphate (PCr/βATP) ratio on cardiac magnetic resonance spectroscopy (MRS) that may play a significant role in the development of heart failure in diabetes. In this study we assessed the role of metabolic impairment and microvascular dysfunction in the development of impaired cardiac energetics in patients with type1 diabetes (T1D). Methods 25 asymptomatic subjects with T1D (mean ± 1 SD, age 32.6 ± 8.2 years) and 26 age-matched healthy controls (HC) (age 32.3 ± 8.0 years) were recruited into the study. We studied two age-matched groups of T1D. The first group was newly diagnosed (10 subjects with an average of 4 years since diagnosis) and the second group was subjects with long-term diabetes (15 subjects with an average of 18 years since diagnosis). All subjects underwent history, echocardiogram and exercise ECG to rule out significant CAD or heart failure. Following this, subjects had MRS to determine the cardiac energetic status and adenosine stress magnetic resonance imaging (MRI) with gadolinium to determine their myocardial perfusion reserve index, which is a measure of coronary flow reserve. Stress MRI was done only in a subgroup of HC (six subjects). Results Baseline characteristics are summarised in the table. A typical cardiac spectrum in T1D and HC is shown in fig 1. The PCr/βATP ratio was significantly reduced in T1D (1.5 ± 0.3 vs 2.1 ± 0.5 in HC, p Conclusions We demonstrate that young patients with uncomplicated T1D have impaired myocardial energetics and that impaired cardiac energetics is independent of coronary microvascular function. We postulate that impairment of cardiac energetics in these subjects primarily results from metabolic dysfunction rather than microvascular impairment.
Multidimension Potential of Surface Plasmon Resonance Imaging for Dynamic Surface Characterization: Application to Optical Biochip Systems (2005)

We have realized a surface plasmon resonance imaging system allowing accurate characterization of biochips. In this paper, the Rouard approach is extended to absorbing layers to model the reflectivity information contained in the multidimensional data.
Controlling side reactions and self-discharge in high-voltage spinel cathodes: the critical role of surface crystallographic facets (2015)

Instabilities resulting from side reactions between the high-voltage cathode and the electrolyte are major barriers to meeting the calendar and cycle life requirements in lithium-ion batteries for vehicular applications. The present study reports a new approach for minimizing the effect of these reactions. LiMn1.5Ni0.5O4 (LMNO) with two distinct morphologies, octahedron with (111) and plate with (112) surface facets, were synthesized in a similar size and investigated for structural changes and electrochemical stability during long-term cycling and storage in the presence of a liquid carbonate electrolyte. Bulk and surface analyses using ICP, XRD, FTIR, soft and hard XAS revealed that in the charged state, the high-valent transition metals in Mn1.5Ni0.5O4 (MNO) oxidatively decompose the electrolyte which results in electron transfer from the electrolyte to the cathode. As a compensation mechanism, Li(+) ions are re-inserted into MNO and the cathode self-discharges. Surface facets where the local redox reactions occur heavily influence the reaction kinetics and selectivity which ultimately determine the nature of the products and rate of self-discharge. Significantly lower self-discharge was observed on octahedra with the (111) facets, benefiting from their ability for promoting sufficient passivation after the initial interaction with the electrolyte. The importance of particle engineering reported in this work has a broad implication in the development of next generation cathode materials with improved performance.
Radiolabeling and PET–MRI microdosing of the experimental cancer therapeutic, MN-anti-miR10b, demonstrates delivery to metastatic lesions in a murine model of metastatic breast cancer (2021)

Our results demonstrate that PET-MRI following a microdose injection of the agent will accurately reflect the innate biodistribution of the therapeutic. The tools developed in the present study lay the groundwork for the clinical testing of MN-anti-miR10b and other similar therapeutics in patients with cancer.
CMOS technologies for retinal prosthesis (2015)

This chapter describes retinal prosthetic devices that are used with complementary metal oxide semiconductor (CMOS) technologies or large-scale integration (LSI) circuit technologies. The introduction of CMOS technologies has made retinal prosthesis systems compact and versatile. Moreover, CMOS technology is particularly effective for increasing the number of stimulus electrodes with limited wiring. The remainder of this chapter is organized as follows. In Section 25.1, the principle of the retinal prosthesis and its basic components are discussed. In Section 25.2, various types of retinal prostheses are described. In Section 25.3, multiple microchip architectures that can realize a large number of stimulus electrodes are introduced and demonstrated in detail. In Section 25.4 integration of a photosensing function in a retinal stimulator is discussed. Finally, Section 25.5 proposes a smart electrode as an avenue for future research in retinal prostheses. A preliminary demonstration is described.
Assay of von Willebrand Factor (vWF)-cleaving Protease Based on Decreased Collagen Binding Affinity of Degraded vWF (1999)

Patients with thrombotic thrombocytopenic purpura (TTP) have a deficiency of von Willebrand factor (vWF)-cleaving protease, whereas patients with hemolytic-uremic syndrome (HUS) show normal activity of this protease. Present methods for assaying vWF-cleaving protease by immunoblotting are time-intensive and cumbersome. We therefore developed a new functional assay based on the preferential binding of high-molecular-weight forms of vWF to collagen. In this assay, the diluted plasma sample to be tested is added to normal human plasma in which protease activity had been abolished. The vWF present in the protease-depleted plasma is digested by the vWF-cleaving protease in the test plasma. The proteolytic degradation leads to low-molecular-weight forms of vWF, which show impaired binding to microtiter plates coated with human collagen type III. The collagen-bound vWF is quantified using a peroxidase-conjugated rabbit antibody against human vWF. The values of vWF-cleaving protease activity in tested plasma samples are read from a calibration curve achieved by incubating the vWF-substrate with dilutions of a normal human plasma pool (NHP). Testing of plasma from patients with TTP and HUS showed that the assay can be used to distinguish between these two syndromes. The presence of an inhibitor can be detected by carrying out the test after incubation of NHP with the patient plasma sample, thus enabling differentiation of patients with familial TTP from those with nonfamilial TTP.
Synthesis of Fused Triazolo‐Imidazole Derivatives by Sequential van Leusen/Alkyne—Azide Cycloaddition Reactions. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Inhibition of Glutamate Carboxypeptidase II by Phosphonamidothionate Derivatives of Glutamic Acid (2001)

A limited series of N-thiophosphonyl-glutamates were found to be inhibitors of the prostate-specific membrane antigen (PSMA) form of glutamate carboxypeptidase II. Comparative inhibitory profiles of an analogous O-thiophosphonyl-2-hydroxyglutarate revealed that the amido-linkage of the N-thiophosphonyl-glutamate provides a significant enhancement of inhibitory potency presumably due to significant hydrogen-bonding interactions with acceptor groups in the active-site of PSMA resulting in tighter binding. An analogous N-phosphonyl-glutamate exhibited significantly greater inhibitory potency than the parent N-thiophosphonyl-glutamate indicating that the sulfur ligand of the N-thiophosphonyl-glutamates is responsible for less favorable active-site interactions than oxygen, potentially due to steric crowding from the longer P-S bond or as a result of active-site metal substitution of Co(II) for Zn(II) arising from assay conditions.
1H1348 Cavity hydration as a gateway to internal mobility : A high pressure ^<13>C and ^<15>N-NMR study of T4 lysozyme(Protein: Property 2,The 49th Annual Meeting of the Biophysical Society of Japan) (2011)

IncorporatedAssociationef ubiquitni) at low and high pregsure
Detection of Colistin Resistance in Escherichia coli by Use of the MALDI Biotyper Sirius Mass Spectrometry System (2019)

Polymyxin antibiotics are a last-line treatment for multidrug-resistant Gram-negative bacteria. However, the emergence of colistin resistance, including the spread of mobile <i>mcr</i> genes, necessitates the development of improved diagnostics for the detection of colistin-resistant organisms in hospital settings. The recently developed MALDIxin test enables detection of colistin resistance by matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) in less than 15 min but is not optimized for the mass spectrometers commonly found in clinical microbiology laboratories. In this study, we adapted the MALDIxin test for the MALDI Biotyper Sirius MALDI-TOF MS system (Bruker Daltonics). We optimized the sample preparation protocol by using a set of 6 mobile colistin resistance (MCR) protein-expressing <i>Escherichia coli</i> clones and validated the assay with a collection of 40 <i>E. coli</i> clinical isolates, including 19 confirmed MCR protein producers, 12 colistin-resistant isolates that tested negative for commonly encountered <i>mcr</i> genes (i.e., likely chromosomally resistant isolates), and 9 polymyxin-susceptible isolates. We calculated polymyxin resistance ratio (PRR) values from the acquired spectra; PRR values of 0, indicating polymyxin susceptibility, were obtained for all colistin-susceptible <i>E. coli</i> isolates, whereas positive PRR values, indicating resistance to polymyxins, were obtained for all resistant strains, independent of the genetic basis of resistance. Thus, we report a preliminary feasibility study showing that an optimized version of the MALDIxin test adapted for the routine MALDI Biotyper Sirius system provides an unbiased, fast, reliable, cost-effective, and high-throughput way of detecting colistin resistance in clinical <i>E. coli</i> isolates.
Nuclear fuels technologies: Thermally induced gallium removal system (TIGRS), fiscal year 1998 research and development test plan (1997)

This document details the research and development (R and D) activities that will be conducted in Fiscal Year 1998 (FY98) by the Thermally Induced Gallium Removal System (TIGRS) team for the Department of Energy Office of Fissile Materials Disposition. This work is a continuation and extension of experimental activities that have been conducted in support of using weapons-derived plutonium in the fabrication of mixed-oxide (MOX) nuclear fuel for reactor-based plutonium disposition. The ultimate purpose of this work is to demonstrate adequate Thermally Induced Gallium Removal with a prototypic system. This Test Plan presents more than the FY98 R and D efforts in order to frame the Task in its entirety. To achieve the TIGRS Program objectives, R and D activities during the next two years will be focused on (1) process development leading to a prototypic TIGRS design, and (2) prototypic TIGRS design and testing leading to and including a prototypic demonstration of TIGRS operation. Both the process development and system testing efforts will consist of a series of surrogate-based cold tests and plutonium-based hot tests. Some of this testing has already occurred and will continue into FY99.