gebhart/patrepeval huggingface dataset:
121. Specific Targeting of Adenoviral Vectors Using the Reovirus Attachment Protein (2004)

Many primary tumors do not express the adenovirus receptor CAR, which limits the applicability of adenoviral vectors (AdV) for cancer gene therapy. The high affinity of reovirus for cancer cells, in particular malignant gliomas, and the structural homology displayed by reovirus attachment protein σ1 and adenovirus fiber suggests that σ1 could be used to target AdV to cancer cells. To investigate this possibility, we generated a fiber/σ1 fusion protein by exchanging the σ1 capsid anchoring-domain for its analog in fiber, the tail domain. The resulting fusion protein efficiently formed trimers, as shown by immunoblotting, and complemented propagation of the fiberless LacZ-expressing AdV, Ad5.βgal.ΔF (Von Seggern et al. J. Virol. 1999, 73: 1601), resulting in infectious virus. Gene transfer by Ad5.βgal.ΔF complemented with the fiber/σ1 fusion protein was inhibited by neutralizing anti-σ1 antibody but not by neutralizing anti-fiber antibody, confirming that σ1 mediated specific cell binding, most probably by interactions with the reovirus receptor, JAM1. Moreover, fiber/σ1-complemented Ad5.βgal.ΔF transduced a small panel of primary human malignant gliomas about 10-fold more efficiently than did AdV containing native fiber.
Ultracompact RGB laser diode module for near-to-eye displays (2021)

We demonstrate a miniaturized, full-color RGB light source module for near-to-eye display systems, incorporating three semiconductor laser diodes (LDs) that are integrated on a free-space, micro-optical bench together with collimation optics and wavelength filters. The ultra-compact package has a footprint of 4.4 mm x 4.15 mm with a height of 2.9 mm (0.053 cm3) and an optical output window for the collimated and collinearly aligned RGB beams. The light source module delivers up to 10 mW per color at low power dissipation values of 640 mW and provides low-divergent output beams having a high circularity and a diameter of 250-650 μm at a reference distance of 50 mm.
Supplementary Data from Tumor Genomic Testing for >4,000 Men with Metastatic Castration-resistant Prostate Cancer in the Phase III Trial PROfound (Olaparib) (2023)

Supplementary Data from Tumor Genomic Testing for &gt;4,000 Men with Metastatic Castration-resistant Prostate Cancer in the Phase III Trial PROfound (Olaparib)
Evaluating Industrial Relations Systems of OECD Countries from 1993 to 2005: A Two‐Dimensional Approach (2014)

Abstract This article uses both cross‐sectional and longitudinal methods to evaluate the national industrial relations systems of 30 O rganisation for E conomic C o‐operation and D evelopment ( OECD ) countries from 1993 to 2005. We adopt a pluralistic view of industrial relations that gives equal weight to efficiency and equity, along with a general systems model consisting of input, process and output. We rank each country in terms of a combined score of efficiency and equity. We find that the 30 OECD countries can be separated into three distinct groups (high on both equity and efficiency; high on efficiency but low on equity; moderate on equity and low on efficiency), and that these groups exhibit considerable stability over time.
Wire-Scanners with Sub-Micrometer Resolution: Developments and Measurements (2019)

Monitors of the beam transverse profile with ever more demanding spatial resolution and minimal invasivity are required by the FEL community. In order to improve the spatial resolution towards the sub-micrometer limit as well as to decrease the impact on the lasing process, nano-fabricated wire-scanners have been manufactured independently at PSI and FERMI by means of a lithographic technique [1,2]. Experimental tests carried out at SwissFEL at a low emittance demonstrated the capability of such innovative wire-scanner solutions to resolve beam transverse profiles with a size of 400-500 nm without being affected by any resolution limit. Status and outlook of nano-fabricated wire-scanners will be presented.
Oxidative Desulfurization of Crude Oil Incorporating Sulfone Decomposition by Alkaline Earth Metal Oxides (2013)

This work explores a novel approach to desulfurization of whole crude oil where thiophenic sulfur compounds are oxidized to sulfones followed by sulfone decomposition into sulfur-free hydrocarbons. The objective of this work is to study the effect of alkaline earth metal oxides on decomposition of sulfones in oxidized crude oil. About 73% of the sulfones in a preoxidized, medium sour crude oil was decomposed over CaO at 360 °C. SO2 was detected by TPD–MS and also measured by a quantitative method when the spent CaO sorbent was thermally treated in an inert atmosphere with sweep gas. No prominent decomposition of sulfur compounds was observed when untreated crude oil (not oxidized) was treated over CaO at 360 °C. This study demonstrates the feasibility of decomposing sulfones in oxidized crude oil over CaO-based materials.
LIGA microsystems aging : evaluation and mitigation. (2003)

The deployment of LIGA structures in DP applications requires a thorough understanding of potential long term physical and chemical changes that may occur during service. While these components are generally fabricated from simple metallic systems such as copper, nickel and nickel alloys, the electroplating process used to form them creates microstructural features which differ from those found in conventional (e.g. ingot metallurgy) processing of such materials. Physical changes in non-equilibrium microstructures may occur due to long term exposure to temperatures sufficient to permit atomic and vacancy mobility. Chemical changes, particularly at the surfaces of LIGA parts, may occur in the presence of gaseous chemical species (e.g. water vapor, HE off-gassing compounds) and contact with other metallic structures. In this study, we have characterized the baseline microstructure of several nickel-based materials that are used to fabricate LIGA structures. Solute content and distribution was found to have a major effect on the electroplated microstructures. Microstructural features were correlated to measurements of hardness and tensile strength. Dormancy testing was conducted on one of the baseline compositions, nickel-sulfamate. Groups of specimens were exposed to controlled thermal cycles; subsequent examinations compared properties of 'aged' specimens to the baseline conditions. Results of our testing indicate that exposure to ambient temperatures (-54 C to 71 C) do not result in microstructural changes that might be expected to significantly effect mechanical performance. Additionally, no localized changes in surface appearance were found as a result of contact between electroplated parts.
Sistema de recomendación para un uso inclusivo del lenguaje (2009)

"Sistema que procesa un texto escrito en castellano detectando usos del lenguaje no inclusivos. Para cada sintagma nominal sospechoso el sistema propone una serie de alternativas. El sistema permite tambi ́en la adquisici ́on autom ́atica de ejemplos positivos a partir de documentos que hagan un uso inclusivo del lenguaje. ́ Estos ejemplos seran usados, junto a su contexto, en la presentaci ́on de sugerencias."
Insulinotropic Effects of Neprilysin and/or Angiotensin Receptor Inhibition in Mice (2022)

Treatment of heart failure with the angiotensin receptor-neprilysin inhibitor sacubitril/valsartan improved glycemic control in individuals with type 2 diabetes. The relative contribution of neprilysin inhibition versus angiotensin II receptor antagonism to this glycemic benefit remains unknown. Thus, we sought to determine the relative effects of the neprilysin inhibitor sacubitril versus the angiotensin II receptor blocker valsartan on beta-cell function and glucose homeostasis in a mouse model of reduced first-phase insulin secretion, and whether any beneficial effects are additive/synergistic when combined in sacubitril/valsartan. High fat-fed C57BL/6J mice treated with low-dose streptozotocin (or vehicle) were followed for eight weeks on high fat diet alone or supplemented with sacubitril, valsartan or sacubitril/valsartan. Body weight and fed glucose levels were assessed weekly. At the end of the treatment period, insulin release in response to intravenous glucose, insulin sensitivity, and beta-cell mass were determined. Sacubitril and valsartan, but not sacubitril/valsartan, lowered fasting and fed glucose levels and increased insulin release in diabetic mice. None of the drugs altered insulin sensitivity or beta-cell mass, but all reduced body weight gain. Effects of the drugs on insulin release were reproduced in angiotensin II-treated islets from lean C57BL/6J mice, suggesting the insulin response to each of the drugs is due to a direct effect on islets and mechanisms therein. In summary, sacubitril and valsartan each exert beneficial insulinotropic, glycemic and weight-reducing effects in obese and/or diabetic mice when administered alone; however, when combined, mechanisms within the islet contribute to their inability to enhance insulin release.
Common Mode Currents in DC Power Routers (2021)

The grid reinforcement and energy redirection needs have led to the emergence of Back-To-Back Voltage Source Converter (BTB-VSC) based dc power routers. This paper investigates the low frequency Common Mode Currents (CMCs) that arise in the system if the employed BTB-VSCs have an un-isolated ac path connected in parallel to their output ports. Simulation results are presented to show a sensitivity analysis of lower order harmonics in CMC with respect to the operating active and reactive power of the dc router, dc link voltage, link resistance, modulation method and pole capacitance. Experimental results are shared to show existance of lower order CMC in 3-wire ac link operating in parallel with the dc power router and these are mitigated using zero sequence controller.
Inverse-designed optical link for chip-to-chip communication (2021)

We experimentally demonstrate a chip-to-chip optical interconnect using inverse-designed silicon photonic circuits. Inverse design optimizes mode-division multiplexing and grating coupler structures in a compact footprint with low insertion loss.
The Promotion of  V Region Hypermutation (1997)

Higher organisms have evolved unusual molecular and genetic mechanisms to generate high affinity and highly specific antibodies to a seemingly infinite number of foreign antigens (([1][1])). Even though a highly diverse germline encoded antibody repertoire is created, most of the antibodies have low
Full Immunologic Reconstitution Following Nonconditioned Bone Marrow Transplantation for Canine X-Linked Severe Combined Immunodeficiency (1997)

Bone marrow transplantation in human X-linked severe combined immunodeficiency (XSCID) without pretransplant conditioning results in engraftment of donor T cells and reconstitution of T-cell function but engraftment of few, if any, donor B cells and poor reconstitution of humoral immune function. Since bone marrow transplantation remains the most effective treatment of XSCID patients, better strategies are necessary to achieve optimum long-term results. Canine XSCID, like human XSCID, is due to mutations in the common gamma chain (gamma c) gene and has clinical and immunologic features identical to those of human XSCID, making it a true homolog of the human disease. We have successfully performed bone marrow transplantation in three XSCID dogs without pretransplant conditioning, using untreated bone marrow cells from mixed lymphocyte culture-nonreactive normal littermates. Unlike the experience in human XSCID patients, all three dogs engrafted both donor B and T cells and attained full reconstitution of immunologic function. Normal percentages of T cells and T-cell mitogenic responses were attained by 3 months posttransplant. CD3+ T cells after transplantation expressed the CD45RA isoform indicating that the cells were recent thymic emigrants derived from immature progenitors. Serum IgG levels were within normal range by 5 months posttransplant. Immunization with the T-dependent antigen, bacteriophage phiX174, demonstrated normal antibody titers, immunologic memory, and class-switching. Polymerase chain reaction (PCR) analysis of the gamma c locus showed that 100% of circulating T cells and 30% to 50% of circulating B cells were donor-derived. None of the dogs developed clinically evident graft-versus-host disease (GVHD). Thus, canine XSCID provides a model to determine the optimal conditions for bone marrow transplantation in human patients, and to develop and test strategies for somatic gene therapy.
Energy Recovery in Supercritical Water Oxydation Process (2008)

This paper focuses on the energy recovery within a supercritical water oxidation process. Such a process might be used for the treatment of aqueous waste or directly for the processing of liquid biomass to recover energy. In the first section of this paper, the main features of such a process are given. It leads to the conclusion that the use of a Rankine's cycle is necessary if electricity production is looked for. In the second section, the technical constraints linked to the use of water at high pressure and high temperature are presented and translated into operating limits that should not be exceeded. Finally, the software ProSimPlus© is used to compute an optimal set of operating parameter, maximizing the electrical efficiency of the whole process. The optimal value of 1.75% was obtained for this parameter, leading to the conclusion that electricity cannot be produced from such a process, but instead, the energy released by the oxidation of the organic compounds should be recovered as heat.
Detection and monitoring of repetitions using an mHealth-enabled resistance band (2018)

Sarcopenia is defined as an age-related loss of muscle mass and strength which impairs physical function leading to disability and frailty. Resistance exercises are effective treatments for sarcopenia and are critical in mitigating weight-loss induced sarcopenia in older adults attempting to lose weight. Yet, adherence to home-based regimens, which is a cornerstone to lifestyle therapies, is poor and cannot be ascertained by clinicians as no objective methods exist to determine patient compliance outside of a supervised setting. Our group developed a Bluetooth connected resistance band that tests the ability to detect exercise repetitions. We recruited 6 patients aged 65 years and older and recorded 4 specific, physical therapist-led exercises. Three blinded reviewers examined the findings and we also applied a peak Ending algorithm to the data. There were 16.6 repetitions per exercise across reviewers, with an intraclass correlation of 0.912 (95%CI: 0.853-0.953, p<0.001) between reviewers and the algorithm. Using this novel resistance band, we feasibly detected repetition of exercises in older adults.
Optimization of the seismic modeling with the time-domain finite-difference method (2014)

We present several strategies to optimize the modeling of the acoustic wavefield with the time-domain finite-difference method. An efficient vectorization of the computations is achieved on the Intel xeon computing core via the modification of the implementation concerning the absorbing layers. We propose also to increase the computational speed by using high orders in space and by solving the second-order wave equation instead of the first-order formulation. These strategies combined together allow for a reduction of the computation time by a factor of 27 for the modeling in the SEG SEAM II model. We show that the optimized algorithm has a quasi-perfect scalability on one dual-socket node.
Ultrahigh-speed DNA sequencing using capillary array electrophoresis chips (1995)

Capillary electrophoresis arrays have been fabricated on planar glass substrates using photolithographic masking and chemical etching. The photolithographically defined channel patterns were first etched in a glass substrate, and then capillaries were formed by thermally bonding the etched substrate to a second glass slide. High-speed separations of restriction fragment digests were performed on these chips in under 1 minute. Multiple separations in the same channel demonstrated excellent reproducibility. Rapid genetic typing of short tandem repeats on the HUMTHO1 locus have also been performed. Finally, separations with single- base resolution have been successful, indicating that these microfabricated devices will also be useful for high-speed DNA sequencing.
Cost Comparisons Of Endoscopic And Surgical Resection Of T1 Rectal Cancer (2021)

Aims The aim of this study was to compare costs of endoscopic and surgical resection and to investigate hypothetical cost scenarios for the treatment of T1 rectal cancer (RC).
A 0.40pJ/cycle 981 μm2 voltage scalable digital frequency generator for SoC clocking (2017)

This work presents an area-efficient voltage and frequency scalable clock generator for low-power digital SoC clocking. Named Direct Digital Sampling and Synthesis (DDSS), the open-loop generator implemented in 28 nm FD-SOI operates from 0.45 V to 1.1V with measured jitter from 1.7% to 5.1% UI. Its low power consumption of 0.40pJ/cycle at 57 MHz 0.5 V combined with the ability to perform fast frequency changes makes this circuit an alternative to PLLs for fast Dynamic Voltage and Frequency Scaling (DVFS) strategies in low power SoCs.
Demonstration of nanoparticle detection using a local evanescent array coupled biosensor (2010)

Nanoparticles with diameter and refractive index similar to viruses were detected by using a local evanescent array coupled biosensor with an integrated photodetector array on a CMOS chip.
Data from An Anti–CLL-1 Antibody–Drug Conjugate for the Treatment of Acute Myeloid Leukemia (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;The treatment of acute myeloid leukemia (AML) has not significantly changed in 40 years. Cytarabine- and anthracycline-based chemotherapy induction regimens (7 + 3) remain the standard of care, and most patients have poor long-term survival. The reapproval of Mylotarg, an anti-CD33–calicheamicin antibody–drug conjugate (ADC), has demonstrated ADCs as a clinically validated option to enhance the effectiveness of induction therapy. We are interested in developing a next-generation ADC for AML to improve upon the initial success of Mylotarg.&lt;/p&gt;Experimental Design:&lt;p&gt;The expression pattern of CLL-1 and its hematopoietic potential were investigated. A novel anti–CLL-1-ADC, with a highly potent pyrrolobenzodiazepine (PBD) dimer conjugated through a self-immolative disulfide linker, was developed. The efficacy and safety profiles of this ADC were evaluated in mouse xenograft models and in cynomolgus monkeys.&lt;/p&gt;Results:&lt;p&gt;We demonstrate that CLL-1 shares similar prevalence and trafficking properties that make CD33 an excellent ADC target for AML, but lacks expression on hematopoietic stem cells that hampers current CD33-targeted ADCs. Our anti–CLL-1-ADC is highly effective at depleting tumor cells in AML xenograft models and lacks target independent toxicities at doses that depleted target monocytes and neutrophils in cynomolgus monkeys.&lt;/p&gt;Conclusions:&lt;p&gt;Collectively, our data suggest that an anti–CLL-1-ADC has the potential to become an effective and safer treatment for AML in humans, by reducing and allowing for faster recovery from initial cytopenias than the current generation of ADCs for AML.&lt;/p&gt;&lt;/div&gt;
SDSAT: Tight Integration of Small Domain Encoding and Lazy Approaches in Solving Difference Logic (2007)

Existing difference logic (DL) solvers can be broadly classified as eager or lazy , each with its own merits and de-merits. We propose a novel difference logic solver SDSAT that combines the strengths of both these approaches and provides a robust pe
Diagnostic Ionizing Radiation Exposure in a Population-Based Cohort of Patients with Inflammatory Bowel Disease (2008)

Annualizing our data, the radiation exposure in the inflammatory bowel disease population was equivalent to the average annual background radiation dose from naturally occurring sources in the U.S. (3.0 mSv). However, a subset of patients had substantially higher doses. The development of imaging management guidelines to minimize radiation dose, dose-reduction techniques in computed tomography, and faster, more robust magnetic resonance techniques are warranted.
Agile Wideband Light Source forOptical Coherence Tomography UsingOptical SSBFrequency SweepTechnique (2007)

per, weusedtwotypes ofmulti-wavelength sources: 1)a Wepropose anagile wideband light source, whichtargeted laser array and2)anoptical combgenerator based onEO onoptical coherence tomography (OCT), consists ofanop- modulation [3]. Generation ofa1.6nm wideband signal tical single-sideband modulation (SSB) frequency sweeper with2MHzrepetition rate (500 nssweeptime) wasdemoncascaded withanoptical frequency combgenerator anda strated bytheSSBmodulation withcombgeneration techmulti-wavelength light source. nique.
Effect of oral branched chain amino acids on behavior and brain serotonin metabolism in portacaval shunted rats (1988)

Abstract It has been suggested that administration of branched chain amino acids (BCAA) can reverse some of the alterations in metabolism and behavior seen in patients with portal‐systemic encephalopathy (PSE). We investigated the effects of a diet enriched in BCAA on serotonin metabolism in the central nervous system (CNS) and on behavior in rats with a chronic portacaval shunt (PCS) . In a first trial (trial 1), an increased CNS serotonin synthesis rate and impaired behavior were observed in PCS rats given a standard laboratory diet. Thereafter, the rats in the trial were given an equicaloric and equinitrogenous diet with (36% BCAA) or without (21% BCAA) BCAA enrichment for an additional 2 weeks. Intake of the BCAA‐enriched diet resulted in normalization of CNS serotonin metabolism, similar to shamoperated rats (with unaltered CNS serotonin metabolism given BCAA enrichment or not), in comparison with PCS rats without BCAA enrichment in their food. The behavioral alterations following PCS were, however, not reversed by BCAA feeding . In a second trial (trial 2), we investigated the behavioral effects of 4 weeks of oral BCAA. From the results, we could state only minor effects of this treatment on impaired behavior following PCS, when compared with PCS without BCAA‐enriched diet . In both trial 1 and 2, the high plasma ammonia levels of the PCS rats were unaffected by the oral treatment of BCAA. The overall nitrogen balance remained comparable between all groups . The present study demonstrates that a BCAA‐enriched diet normalizes CNS serotonin metabolism in the PCS rat. The impaired behavioral performances could not, however, be completely reversed, suggesting that factors other than brain serotonin may also be involved in the development of PSE .