gebhart/patrepeval huggingface dataset:
Ribophorin II (RPN2) as a novel therapeutic target for cancer stem cells (2011)

The survival rate for women with advanced, metastatic breast cancer has not changed significantly for decades. Regardless of effective therapies, many women still experience recurrences of breast cancer after treatment. Chemotherapy with docetaxel (and other anti-cancer reagents) is widely used for the treatment of breast cancer. Despite an initial response to treatment, the sensitivity to anti-cancer reagents decreased. This leads to progressive disease, normally with fatal consequences. We previously demonstrated that ribophorin II (RPN2), which is part of an N-oligosaccharyl transferase complex, regulates the drug resistance in breast cancer cells and silencing of RPN2 by RNAi-based oligonucleotides is a promising approach to overcome the drug-resistant tumor (Honma K. et al., 2008, Nat Med). In the current study, we examined the role of RPN2 in cancer stem cell (CSC) fraction that is responsible for drugresistance and metastasis. Cell sorting coupled with realtime qPCR analysis showed that RPN2 is highly expressed in CSC fraction. Furthermore, RPN2-knockdown in CSC fraction reduced cancer stem cell frequency, as shown by flow cytometric and in vivo tumorigenicity studies. Thus, these results suggest that RPN2 might be a promising novel target toward the cancer stem cell therapy. L3.2
Dynamic Slice Scaling Mechanisms for 5G Multi-domain Environments (2021)

Network slicing is an essential 5G innovation whereby the network is partitioned into logical segments, so that Communication Service Providers (CSPs) can offer differentiated services for verticals and use cases. In many 5G use cases, network requirements vary over time and CSPs must dynamically adapt network slices to satisfy the contractual network slice QoS, cooperating and using each others’ resources, e.g. when resources of a single CSP are not sufficient or suitable to maintain all it’s current SLAs. While this need for dynamic cross-CSP cooperation is widely recognized, realization of this need is not yet possible due to gaps both in business processes and in technical capabilities.In this paper, we present a 5GZORRO approach to dynamic cross-CSP slice scaling. Our approach both enables CSPs to collaborate, providing security and trust with smart multi-party contracts, and facilitates thus achieved collaboration to enable resource sharing across multiple administrative domains, either during slice establishment or when already existing slice needs to expand or shrink. Our approach allows automating both business and technical processes involved in dynamic lifecycle management of cross-CSP network slices, following ETSI’s Zero-Touch Network and Service Management (ZSM) closed-loop architecture, and relying on resource-sharing Marketplace, Distributed Ledger (DL), and Operational Data Lake. We show how this approach is realized in truly Cloud Naive way, with Kubernetes as both business and technical cross-domain orchestrator. We then showcase applicability of the proposed solution for dynamic scaling of Content Delivery Network (CDN) service.
P4‐203: Expression and characterization of a novel Aβ oligomer and fibril conformer‐specific single‐chain variable fragment (scFv) that was selected using Aβ1‐16 linear sequence (2012)

Alzheimer's disease is a progressive neurodegenerative disorder with devastating effects. Currently, only palliative therapies are available. In recent years, Aβ immunotherapy has become a promising tool for the treatment of AD. Both, entire antibodies as well as antibody fragments, have been shown to reduce amyloid- β (Aβ) plaque burden and ameliorate cognitive deficits in AD mouse models. However, clinical trials with active immunization using Aβ encountered severe complications, for example meningoencephalitis. Alternatively, single-chain variable fragments (scFvs) can be used in therapeutic approaches. These were shown to alter Aβ aggregation and toxicity. We selected an IgG using the N-terminal region of A β in the selection procedure. The corresponding single-chain variable fragment (scFv) was expressed in E. coli, purified and characterized regarding its interaction with different A β species and its influence on A β fibril formation using biophysical and in silico methods. We were able to show that the identified scFv strongly influenced the aggregation behavior of A β. Moreover, it also bound to A β oligomers and fibrils with higher affinity than to Aβ monomers, although it was selected using Aβ1-16. Docking experiments suggest that the scFv binds to His14 und Lys16 of the N-terminal pile of Aβ fibrils. Because the identified scFv specifically targets higher oligomeric species of Aβ and prevents Aβ fibril formation, it would be a valuable candidate for therapeutic approaches.
Evaluation of Composites Containing Hollow Ni/Fe-Co Fibers on Near-Field Electromagnetic Wave Absorbing Properties (2010)

In order to develop an effective near-field electromagnetic (EM) wave absorber, we have fabricated polymeric thin films including hollow metallic microfibers. Hydrolyzed polymer micro fibers (~2.5 ㎛) were used as a substrate material for the electroless metal plating. Nickel and subsequent Fe-Co metal layers were coated on the surface of activated polymer fibers and then heat treatment for the hollow structure as well as the densification of metallic layers was performed under the Argon atmosphere. Unlike conventional particulate or flaky metal powders, these fibers can play a significant role in elevating the magnetic property of polymer films, resulting in the increased efficiency of EM absorbing properties. In addition, their hollow structure can also lower their apparent density. SEM and EDS analysis were carried out to verify the morphology and metal compositions. Polymeric thin films containing hollow Ni/Fe-Co micro fibers were prepared to investigate the effect of metal compositions, filler distribution and heat treatment conditions on not only the near-field absorbing performance, but also magnetic properties such as permeability and magnetization. For the measurement of near-field EM absorbance in the frequency range of ~6GHz, micro strip line and network analyzer were used.
Relationships between membrane lipid composition and biological properties of rat myocytes. Effects of aging and manipulation of lipid composition. (1985)

Cultures of newborn rat heart myocytes undergo major age-related alterations as demonstrated by comparing 5-6-day-old cells ("young cells") and 14-15-day-old cells ("old cells"). This includes: changes from spherical to elongated shape; sphingomyelin and cholesterol level/cell increase by 100% and 50%, respectively, while the phosphatidylcholine is reduced by 15-20% with almost no change in content of total phospholipids. There is a 50% increase in total protein content/cell while DNA content remain constant. The specific activity of seven marker enzymes representing most subcellular organelles is increased. Beating rate is reduced from 160 +/- 20 to 20 +/- 20 beats min-1. All the above age-dependent alterations are affected by modification of cellular polar lipid composition. Small unilamellar vesicles of egg phosphatidylcholine added to the growth medium of old cells serve as donor of egg phosphatidylcholine to the cells and as acceptor of cellular sphingomyelin and cholesterol. Sphingomyelin-phospholipid exchange can be separated from cholesterol depletion either by using vesicles of egg phosphatidylcholine/cholesterol mixtures which serve only in the phospholipid exchange process, or by small unilamellar vesicles of sphingomyelin which act only as efficient cholesterol acceptors. Such experiments indicated that the major response of old cells is to alteration in the phosphatidylcholine to sphingomyelin mole ratio, while changes in the cholesterol level induce smaller effects. Thus, reversal of phosphatidylcholine to sphingomyelin mole ratio to the values shown by young cells reverse cellular functions and features which were altered by cell aging to levels found in young cells. This includes: increase in the beating rate back to 160 +/- 20, reduction in the total protein level and in the specific activity per DNA content of seven marker enzymes and reappearance of spherical cell shape. These results suggest that membrane lipid composition has major influence on cellular properties which as described in the accompanying paper (Yechiel, E., Barenholz, Y., and Henis, Y. I. (1985) J. Biol. Chem. 260, 9132-9136), may be mediated through the organization and dynamics of the cell membranes.
Phase-shift soft-switching power amplifier with lower EMI noise (2014)

This work presents detailed analysis for a phase-shift soft switching inverter. The optimum soft switching operation algorithm is proposed based on the maximum soft switching operation range and also the smallest device current stress. Meanwhile, the soft switching control algorithm is proposed to guarantee the zero-voltage-switching (ZVS) within each switching period. A compact coupled circulating inductor based on the spiral structure is utilized to provide circulating current for the soft switching. Other design considerations such as the minimum circulating current for ZVS operation, dead time selection are also included. Finally, a 600V, 300A prototype is demonstrated to show the feasibility of reducing the EMI noise through soft-switching technique.
Finite control set MPC of an AFE rectifier with dynamic references (2010)

We present a model predictive controller for closed loop control of an active front-end rectifier. Our method operates in discrete-time and does not require additional modulators or external control loops. The key novelty of the control algorithm presented lies in the way dynamic references are handled. Simulation studies illustrate that fast and accurate tracking of dynamic dc-voltage and reactive power references can be achieved, while respecting restrictions on maximum power levels of the rectifier.
Motion detection and analysis of matching graphs of intermediate-level primitives (1980)

Introduces a new primitive, the half-chunk, for encoding boundary, region, and surface information in graph form. General graph matching is discussed and a specific graph matching system based on half-chunk graphs is presented. Following matching, bindings are interpreted as object component motion or depth. The half-chunk graph allows scale and coordinate system independent object models to be represented. Half-chunk graphs may encode 2-D or 3-D structure equally well.
Gas transport properties of polymers based on spirobiindane bisphenol (1995)

Abstract Transport properties of pure gases in polycarbonates, polyesters, and polyetherimides based on 6,6′‐dihydroxy‐3,3,3′,3′‐tetramethyl‐1,1′‐spiro biindane (SBI) and bisphenol‐A (BPA) are compared at 35°C. The SBI monomer contains two spiro‐linked five‐membered rings which are fused to the phenyl rings at the meta and para positions to the hydroxyl groups. This molecular structure gives SBI‐based polymers with higher fractional free volume (FFV) and lower intramolecular motions as compared to the BPA‐based analogs. The inhibition of chain packing due to the SBI moiety yields polymers with much higher permeabilities for all the gases studied, despite the hinderance of mobility associated with the SBI structure. Simultaneous increase in selectivity was also observed for some gas pairs. Oxygen permeabilities up to 5.9‐fold higher with increases of up to 13% in O 2 /N 2 selectivities were observed for a polyester based on SBI as compared to its analog based on BPA. Higher permeabilities of up to 4.3‐fold for He and up to 4.8‐fold for CO 2 were observed due to the substitution of SBI for BPA. Not surprisingly, lower values of He/CH 4 and CO 2 /CH 4 selectivities were obtained for the more open SBI‐containing polymers. The changes in fractional free volume and inhibition of small‐scale mobility for some materials caused by the SBI moiety were measured and used in the interpretation of the gas transport properties. The individual contributions of diffusivity and solubility to the overall transport behavior of the polymers are discussed and correlated to the structural alterations caused by the SBI substitution for BPA monomer. © 1995 John Wiley &amp; Sons, Inc.
New NRL glasses for multispectral imagers in visible to LWIR (Conference Presentation) (2020)

NRL is developing new glasses that transmit within the visible to LWIR range for use in multispectral imaging. We had previously developed NRL glasses which transmit in 0.9 to &gt; 12 µm in wavelength, with refractive index ranging from 2.38 to 3.17, to expand the glass map and provide compact solutions to multispectral imaging systems. These glasses were specifically designed to have comparable glass molding temperatures and thermal properties so that they can be laminated and co-molded into optics with reduced number of air-glass interfaces (lower Fresnel reflection losses). These NRL glasses also have negative or very low dn/dT, making it easier to athermalize the optical system. A set of NRL glasses can be diffused to make infrared graded index (IR-GRIN) optics. Our multispectral optics designs using these new materials demonstrate reduced size, complexity and improved performance. The glass database compatible with Zemax and CodeV is available for distribution. We are adding n
IP interpretation in environmental investigations (2002)

Abstract The induced polarization (IP) response of rocks and soils is a function of lithology and fluid conductivity. IP measurements are sensitive to the low-frequency capacitive properties of rocks and soils, which are controlled by diffusion polarization mechanisms operating at the grain-fluid interface. IP interpretation typically is in terms of the conventional field IP parameters: chargeability, percentage frequency effect, and phase angle. These parameters are dependent upon both surface polarization mechanisms and bulk (volumetric) conduction mechanisms. Consequently, they afford a poor quantification of surface polarization processes of interest to the field geophysicist. A parameter that quantifies the {magnitude} of surface polarization is the normalized chargeability, defined as the chargeability divided by the resistivity magnitude. This parameter is proportional to the quadrature conductivity measured in the complex resistivity method. For nonmetallic minerals, the quadrature conductivity and normalized chargeability are closely related to lithology (through the specific surface area) and surface chemistry. Laboratory and field experiments were performed to determine the dependence of the standard IP parameters and the normalized chargeability on two important environmental parameters: salinity and clay content. The laboratory experiments illustrate that the chargeability is strongly correlated with the sample resistivity, which depends on salinity, porosity, saturation, and clay content. The normalized chargeability is shown to be independent of the sample resistivity and it is proportional to the quadrature conductivity, which is directly related to the surface polarization processes. Laboratory-derived relationships between conductivity and salinity, and normalized chargeability and clay content, are extended to the interpretation of 1-D and 2-D field-IP surveys. In the 2-D survey, the apparent conductivity and normalized chargeability data are used to segment the images into relatively clay-free and clay-rich zones. A similar approach can eventually be used to predict relative variations in the subsurface clay content, salinity and, perhaps, contaminant concentrations.
First-principles study of the adsorption ofC2H2andC2H4on Si(100) (2001)

The adsorption of acetylene and ethylene on the Si(100) surface is studied by first-principles density-functional calculations within the generalized gradient approximation. Both molecules are found to adsorb identically on the top of Si dimers, forming two \ensuremath{\sigma} bonds between C and Si atoms. This result does not support a recent photoelectron imaging observation where the adsorption sites of the two molecules differ from each other. Controversial issues, such as the intactness of the Si dimer bond and the saturation coverages of both adsorbed molecules, are discussed.
バナジウム-リン系複合酸化物(P/V=2)触媒のブタンからの無水マレイン酸合成能 (1997)

Vanadium-phosphorus mixed oxide catalysts (V-P-O) having P/V ratio of 2 have been investigated for the synthesis of maleic anhydride (MA) from butane. The V-P70 catalyst consisted of amorphous phase and/or (VO) 2P4012 phase when the precursor VO (H2PO4)2 was calcined in the temperature range of 500-780℃. The V-P-O catalyst exhibited a good MA selectivity of 45-53 mol% in the butane oxidation at 470-500℃although butane conversion remained at a low level (&lt;40mol%) because of the small specific surface area of the catalyst (1-2.5m2・g-1). The addition of metal cations modified the catalytic properties of amorphous V-P-O catalyst. Particularly, the MA yield was enhanced for the Co-added amorphous catalyst. On the other hand, metal cations could not be incorporated into the crystal lattice of (VO)2P4012 so that their addition hardly improved the catalytic properties of crystalline (VO)2P4012 catalyst.
The Homoaromatic 1-Hydroxyhomotrophylium Cation (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Homoaromatic 1-Hydroxyhomotrophylium CationM. Brookhart, M. Ogliaruso, and S. WinsteinCite this: J. Am. Chem. Soc. 1967, 89, 8, 1965–1966Publication Date (Print):April 1, 1967Publication History Published online1 May 2002Published inissue 1 April 1967https://pubs.acs.org/doi/10.1021/ja00984a045https://doi.org/10.1021/ja00984a045research-articleACS PublicationsRequest reuse permissionsArticle Views73Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Figure S2 from Regulation of eIF4F Translation Initiation Complex by the Peptidyl Prolyl Isomerase FKBP7 in Taxane-resistant Prostate Cancer (2023)

&lt;p&gt;FKBP7 upregulation at mRNA and protein levels&lt;/p&gt;
Protein phosphorylation and protein kinase activities in BC3H-1 myocytes. Differences between the effects of insulin and phorbol esters. (1986)

To determine whether insulin activates protein kinase C in BC3H-1 myocytes, we evaluated changes in protein phosphorylation, protein kinase activities, and the intracellular translocation of protein kinase C activity in response to insulin and phorbol esters. Phorbol 12-myristate 13-acetate (PMA), but not insulin, stimulated the phosphorylation of an acidic Mr 80,000 protein which has been shown to be an apparently specific marker for protein kinase C activation. In addition, PMA, but not insulin, stimulated the rapid association of protein kinase C activity with a cellular particulate fraction. In contrast to these differences, both insulin and PMA stimulated the phosphorylation of ribosomal protein S6 and activated a ribosomal protein S6 kinase in cell-free extracts from cells exposed to these agents. In cells exposed to high concentrations of PMA for 16 h, protein kinase C activity and immunoreactivity were abolished, without changes in cellular morphology. Under these conditions, insulin, but not PMA, stimulated phosphorylation of the ribosomal protein S6 in intact cells and activated the S6 kinase in cell-free extracts derived from insulin-treated intact cells. We conclude that: insulin does not appear to activate protein kinase C in BC3H-1 myocytes, at least as assessed by phosphorylation of the Mr 80,000 protein; both insulin and PMA activate an S6 protein kinase in these cells; and insulin can promote S6 phosphorylation and activate the S6 kinase normally in protein kinase C-deficient cells. Activation of the S6 kinase by insulin and PMA, although apparently proceeding through different mechanisms, may explain some of the similar biological actions of these compounds in BC3H-1 myocytes.
Identification of Interleukin-8-Reducing Lead Compounds Based on SAR Studies on Dihydrochalcone-Related Compounds in Human Gingival Fibroblasts (HGF-1 cells) In Vitro (2020)

<b>Background:</b> In order to identify potential activities against periodontal diseases, eighteen dihydrochalcones and structurally related compounds were tested in an established biological in vitro cell model of periodontal inflammation using human gingival fibroblasts (HGF-1 cells). Methods: Subsequently to co-incubation of HGF-1 cells with a bacterial endotoxin (<i>Porphyromonas gingivalis</i> lipopolysaccharide, <i>pg</i>LPS) and each individual dihydrochalcone in a concentration range of 1 µM to 100 µM, gene expression of interleukin-8 (IL-8) was determined by qPCR and cellular interleukin-8 (IL-8) release by ELISA. <b>Results</b>: Structure-activity analysis based on the dihydrochalcone backbone and various substitution patterns at its aromatic ring revealed moieties 2',4,4',6'-tetrahydroxy 3-methoxydihydrochalcone (<b>7</b>) to be the most effective anti-inflammatory compound, reducing the <i>pg</i>LPS-induced IL-8 release concentration between 1 µM and 100 µM up to 94%. In general, a 2,4,6-trihydroxy substitution at the A-ring and concomitant vanilloyl (4-hydroxy-3-methoxy) pattern at the B-ring revealed to be preferable for IL-8 release inhibition. Furthermore, the introduction of an electronegative atom in the A,B-linker chain led to an increased anti-inflammatory activity, shown by the potency of 4-hydroxybenzoic acid <i>N</i>-vanillylamide (<b>13</b>). <b>Conclusions:</b> Our data may be feasible to be used for further lead structure designs for the development of potent anti-inflammatory additives in oral care products.
Reliable and Large Area Organic Solar Cells on Flexible Foil Substrates (Final Report) (2019)

Mature solar technologies are now providing energy in a growing number of locales across the US at costs below that of fossil fuels. In short, solar energy is delivering on its promise of over 60 years as a source of low cost, clean and literally infinite renewable energy. However, basing all solar solutions on existing materials systems, such as silicon, is insufficient. To be impactful, new solutions must enable the ubiquitous presence of solar power generation.
ChemInform Abstract: Total Synthesis and Stereochemistry of Mycolactone F (I). (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Superparamagnetic imposed diatom frustules for the effective removal of phosphates (2013)

Diatom frustules coated with magnetite nanoparticles 21 nm in size were synthesised without the requirement of stabilisers, or prior functionalisation of the frustule surface, with the resulting material exhibiting superparamagnetic behaviour, and with a high capacity for phosphate ion adsorption.