gebhart/patrepeval huggingface dataset:
Pan and Sentinel Lymph Node Visualization Using a Near-Infrared Fluorescent Probe (2003)

A number of different types of agents have been employed to aid in the visualization of lymph nodes, particularly the sentinel lymph node, and to decrease the tissue destruction associated with the diagnosis of nodal metastases. The current study was performed to see if a novel macromolecular near-infrared fluorescent (NIRF) probe could be used to visualize lymph nodes after intravenous administration (pan-node visualization) or subcutaneous administration (sentinel node visualization), and serve as method for guiding dissection with interventional radiologic and surgical procedures. Cy5.5-PGC, the near-infrared dye Cy5.5 coupled to a protected graft copolymer (PGC), was injected (iv or sc) into nude mice. Twenty-four hours later white light and NIRF images were obtained on (i) the live animal, (ii) a partially dissected animal, and (iii) tissue specimens. With Cy5.5-PGC administered intravenously, axillary nodes were visualized from outside a living mouse. With partial dissection, iliac and aortic nodes were visible as concentrated foci of high-intensity NIRF signals. With subcutaneous injection in the front extremity, axillary and brachial nodes draining the injection site were easily visualized. NIRF imaging provides a nonradioactive method of visualizing lymph nodes through layers of tissue that can be employed with intravenous or subcutaneous injection.
AlignNet: Unsupervised Entity Alignment (2020)

Recently developed deep learning models are able to learn to segment scenes into component objects without supervision. This opens many new and exciting avenues of research, allowing agents to take objects (or entities) as inputs, rather that pixels. Unfortunately, while these models provide excellent segmentation of a single frame, they do not keep track of how objects segmented at one time-step correspond (or align) to those at a later time-step. The alignment (or correspondence) problem has impeded progress towards using object representations in downstream tasks. In this paper we take steps towards solving the alignment problem, presenting the AlignNet, an unsupervised alignment module.
Identification of Interleukin 40, a novel B cell-associated cytokine. (2017)

Abstract We have identified a novel mouse and human cytokine. IL-40 is normally produced in the bone marrow and fetal liver, and by activated B cells. Its sequence predicts a small (~27kDa) secreted protein unrelated to other cytokine gene families, that we have called Interleukin 40 (IL-40). IL40 is only present in mammalian genomes, suggesting a role in mammalian immune responses. Accordingly, IL-40 expression is induced in the mammary gland upon the onset of lactation, and an IL-40−/− mouse exhibits reduced levels of IgA in the serum, gut, feces, and milk. Furthermore, the IL-40−/− mouse has smaller and fewer Peyer’s patches and IgA secreting cells. The gut microbiome of IL-40−/− mice also exhibits altered composition, reflecting the reduced levels of IgA in the gut. We have also determined that B cell precursor populations are altered in the IL-40−/− mouse. Taken together, these observations indicate that IL-40 represents a novel B cell associated cytokine, that plays an important role in the development of humoral immune responses. IL-40 is also expressed by human activated B cells and by several human B cell lymphomas. The latter observation suggests that it may play a role in the pathogenesis of these diseases.
Helicobacter pylori-negative gastric ulcer. (1992)

Causes of Helicobacter pylori (HP)-negative gastric ulcers (GUs) have not previously been systematically studied. In this study we examined possible causes of HP-negative GUs. Among 115 consecutive patients with endoscopic diagnoses of GU, 71 (62%) had HP infection, and 44 (38%) were found to be HP-negative. Of the 71 HP-positive patients, 47 (66%) had no other detectable causal factors, 21 (30%) were regularly taking nonsteroidal antiinflammatory drugs (NSAIDs), and three (4%) had malignant GU. Of the 44 HP-negative patients, 29 (66%) were taking NSAIDs, two (5%) had a malignant GU, whereas 13/44 (30%) (11% of total 115) patients had no identifiable cause. These patients were classified as having "idiopathic GU." Some 38/115 (33%) GUs occurred on the lesser curve, and these were more often (p = 0.012) HP-positive (76%) than prepyloric GUs (60/115 (52%)). We conclude that although most patients have an identifiable cause of GU, around 11% will have no apparent contributing factor. HP-positive GUs are more frequently located on the lesser curve. It is now important to identify the cause of GU, because this may dictate choice of management.
A Kind of Method for Direction of Arrival Estimation Based on Blind Source Separation (2008)

Direction of arrival estimation and signal recovery are the bases of the underwater target tracking and target recog- nition,respectively.Based on the average time-delayed correla- tion matrices,a new kind of complex blind source separation is proposed.Then the DOA estimation and the corresponding signals of targets are calculated based on this method.Experi- mental results show that this method is superior to the multiple signal classification (MUSIC) method for realizing the same res- olution at the same situation.
Detection of influence of brain-stem neurons and intra-cranial field potentials on the diaphragm activity (2002)

The archival magnetic typed data of experiments with cat wakefulness and sleep are analyzed. General goals and possible tools for the analysis of non-linear interactions in the nervous system are discussed The interaction between air-flow data, ponto-geniculo-occipital (PGO) waves, brain-stem neurons and electrical activity recorded in the diaphragm is analyzed. The analysis methods are engineered to meet the data processing requirements and include the analysis of individual potential waves and procedures for treating the non-stationary properties of the signals due to respiration. This analysis has definitely confirmed the existence of inhibition, which PGO waves exert on the diaphragm activity, and patterns of interaction of neurons with the diaphragm.
Viscosity, solubility, density of isopropenyl stearate and isopropenyl acetate (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTViscosity, solubility, density of isopropenyl stearate and isopropenyl acetateMichael F. KozempelCite this: J. Chem. Eng. Data 1971, 16, 3, 345–346Publication Date (Print):July 1, 1971Publication History Published online1 May 2002Published inissue 1 July 1971https://pubs.acs.org/doi/10.1021/je60050a011https://doi.org/10.1021/je60050a011research-articleACS PublicationsRequest reuse permissionsArticle Views88Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Vascular Aging Detected by Peripheral Endothelial Dysfunction Is Associated With ECG‐Derived Physiological Aging (2021)

Background An artificial intelligence algorithm that detects age using the 12-lead ECG has been suggested to signal "physiologic age." This study aimed to investigate the association of peripheral microvascular endothelial function (PMEF) as an index of vascular aging, with accelerated physiologic aging gauged by ECG-derived artificial intelligence-estimated age. Methods and Results This study included 531 patients who underwent ECG and a noninvasive PMEF assessment using reactive hyperemia peripheral arterial tonometry. Abnormal PMEF was defined as reactive hyperemia peripheral arterial tonometry index ≤2.0. Accelerated or delayed physiologic aging was calculated by the Δ age (ECG-derived artificial intelligence-estimated age minus chronological age), and the association between Δ age and PMEF as well as its impact on composite major adverse cardiovascular events were investigated. Δ age was higher in patients with abnormal PMEF than in patients with normal PMEF (2.3±7.8 versus 0.5±7.7 years; <i>P</i>=0.01). Reactive hyperemia peripheral arterial tonometry index was negatively associated with Δ age after adjustment for cardiovascular risk factors (standardized β coefficient, -0.08; <i>P</i>=0.048). The highest quartile of Δ age was associated with an increased risk of major adverse cardiovascular events compared with the first quartile of Δ age in patients with abnormal PMEF, even after adjustment for cardiovascular risk factors (hazard ratio, 4.72; 95% CI, 1.24-17.91; <i>P</i>=0.02). Conclusions Vascular aging detected by endothelial function is associated with accelerated physiologic aging, as assessed by the artificial intelligence-ECG Δ age. Patients with endothelial dysfunction and the highest quartile of accelerated physiologic aging have a marked increase in risk for cardiovascular events.
Zeolite-Based Catalysis for Phenol Production (2021)

Phenol is an important chemical commodity utilized for several applications (e.g., polycarbonate, epoxy–resins, phenolic resins, nylon). Its conventional production starts from benzene and propylene and is based on a series of reaction steps most of which are catalyzed by acid catalysts. Besides this technology other ones have been considered during the last decades, starting from other reactants and catalysts. Looking at the catalyst types both already in use or under evaluation, it is interesting to note that zeolites, as acidic catalysts or red-ox catalysts, were widely investigated. Therefore, the production of phenol represents a fascinating example of how zeolite catalysis contributes to improving the sustainability of these chemical processes by displacing the previous large use of corrosive and dangerous liquid acids and improving overall selectivity, which reduces the side production of wastes. Aromatic alkylation, transalkylation, and disproportionation, oxidations, rearrangements, oligomerization, and cracking are the reactions occurring in phenol production technologies, but also key unit operations in refineries and the chemical industry. A review of the zeolite catalysts utilized and proposed by major licensors and research groups in these technologies is provided as well as a discussion of key process differences and recent advances.
Visit – Visualization And Information Technology A Multi Tier System For Interdisciplinary Experiences In Data Collection And Visualization (2020)

Collaboration on interdisciplinary teams is an important experience for computer science students, and one that is too rarely available. Methods for data collection in the field and subsequent graphing and analysis are important skills for students in many different scientific disciplines. This paper presents a project currently underway by computer science and environmental science faculty at the California State University, Chico to address these needs. A multi-tier system is being developed to serve as a repository for data collected in the field by environmental science students, facilitate graphing and analysis of data, and provide a platform for interdisciplinary teams of students to collaborate on both software development and data analysis tasks.
Mammosomatotropes in human pituitary adenomas as revealed by electron microscopic double gold immunostaining method (1988)

Hormone production was studied in situ by immunocytochemical methods in 20 pituitary adenomas. Special attention was given to 13 adenomas removed from acromegalic patients. Out of them, 6 had mild to moderate hyperprolactinemia. Immunohistochemistry revealed PRL-containing cells without any close relationship with high PRL serum level in 6 patients. Double immunogold staining revealed mammosomatotrope cells characterized by simultaneous presence of GH and PRL in the same granules in 2 patients. Since mammosomatotropes have never been demonstrated in the normal pituitary, our results probably signify gene dysregulation in pituitary cells of those acromegalic patients.
Probing for requirements knowledge to stimulate architectural thinking (2016)

Software requirements specifications (SRSs) often lack the detail needed to make informed architectural decisions. Architects therefore either make assumptions, which can lead to incorrect decisions, or conduct additional stakeholder interviews, resulting in potential project delays. We previously observed that software architects ask Probing Questions (PQs) to gather information crucial to architectural decision-making. Our goal is to equip Business Analysts with appropriate PQs so that they can ask these questions themselves. We report a new study with over 40 experienced architects to identify reusable PQs for five areas of functionality and organize them into structured flows. These PQ-flows can be used by Business Analysts to elicit and specify architecturally relevant information. Additionally, we leverage machine learning techniques to determine when a PQ-flow is appropriate for use in a project, and to annotate individual PQs with relevant information extracted from the existing SRS. We trained and evaluated our approach on over 8,000 individual requirements from 114 requirements specifications and also conducted a pilot study to validate its usefulness.
R-Storm (2015)

The era of big data has led to the emergence of new systems for real-time distributed stream processing, e.g., Apache Storm is one of the most popular stream processing systems in industry today. However, Storm, like many other stream processing systems lacks an intelligent scheduling mechanism. The default round-robin scheduling currently deployed in Storm disregards resource demands and availability, and can therefore be inefficient at times. We present R-Storm (Resource-Aware Storm), a system that implements resource-aware scheduling within Storm. R-Storm is designed to increase overall throughput by maximizing resource utilization while minimizing network latency. When scheduling tasks, R-Storm can satisfy both soft and hard resource constraints as well as minimizing network distance between components that communicate with each other. We evaluate R-Storm on set of micro-benchmark Storm applications as well as Storm applications used in production at Yahoo! Inc. From our experimental results we conclude that R-Storm achieves 30-47% higher throughput and 69-350% better CPU utilization than default Storm for the micro-benchmarks. For the Yahoo! Storm applications, R-Storm outperforms default Storm by around 50% based on overall throughput. We also demonstrate that R-Storm performs much better when scheduling multiple Storm applications than default Storm.
Synthesis and Characterization of a New Three‐Dimensional Organically Templated Nickel‐Zinc Phosphate. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Evaluation of Flow-Injection Tandem Mass Spectrometry for Rapid and High-Throughput Quantitative Determination of B Vitamins in Nutritional Supplements (2012)

The use of flow-injection electrospray ionization tandem mass spectrometry for rapid and high-throughput mass spectral analysis of selected B vitamins, viz., B1, B2, B3, B5, and B6, in nutritional formulations was demonstrated. A simple and rapid (~5 min) in-tube sample preparation was performed. Automated flow injection introduced 1 μL of the extracts directly into the mass spectrometer ion source without chromatographic separation. Sample-to-sample analysis time was 60 s. Quantitative capabilities of the flow-injection analysis were tested using the method of standard additions and SRM 3280. The quantity determined for each B vitamin in SRM 3280 was within the statistical range provided for the respective certified values. This approach was also applied to two different commercial vitamin supplement tablets and proved to be successful in the quantification of the selected B vitamins, as evidenced by an agreement with the label values and the results obtained using isotope dilution liquid chromatography/mass spectrometry.
Network architectures and research issues in cooperative cellular wireless networks (2011)

The systematic study of relaying and cooperation in the context of digital communication goes back to the work of Van der Meulen and Cover and El Gamal. The basic relay channel of consists of a source, a destination, and a relay node. The system models in are either discrete memoryless channels (DMC), or continuous-valued channels which are characterized by constant (nonrandom) links and additive white Gaussian noise.
Abstract 4850: Paired-end RNA-sequencing based identification of 24 novel fusion genes in breast cancer (2011)

Abstract Fusion genes have recently been described in common solid tumors, revealing an important class of mutations that contribute to cancer development and progression. Next-generation sequencing technologies allow systematic characterization of cancer cell transcriptomes, including the fusion genes resulting from underlying chromosomal translocations. Using paired-end RNA-sequencing in conjunction with high-resolution chromosomal copy number analyses we characterized 24 novel and 3 previously known fusion genes in breast cancer cell lines. An improved bioinformatic approach allowed fusion gene validation with a 95% success rate by RT-PCR, Sanger sequencing and FISH. Among the identified fusions, partner genes were found to contribute both promoters (5′UTR; e.g. TATDN1-GSDMB), coding sequences (e.g. ACACA-STAC2) as well as 3′UTRs (e.g. CSE1L-ENSG00000236127). Most fusion genes (82%) were associated with copy number transitions, such as high level amplifications at e.g. 8q21, 17q12, 17q23 and 20q13, implying that fusion gene formation may contribute to the selective advantage provided by copy number amplifications. Although no prevalent single fusion gene was detected, the functional importance of the multiple fusion genes is supported by several lines of evidence. First, some of the fusion partner genes were expressed exclusively as fusion transcripts, e.g. TATDN1-GSDMB, indicating that the fusion event lead to the activation of a latent gene. Second, several fusion gene partners, including ACACA, NOTCH1 and RARA, have been previously found to be involved in oncogenic fusions in leukemias and lymphomas. Third, functional analysis using RNAi-mediated knockdown suggested a potential role for two fusion genes in controlling cancer cell proliferation. In conclusion, using RNA-sequencing together with improved bioinformatics and genomic copy number profiling, we have discovered multiple novel fusion genes in breast cancer, which may provide new insights on breast cancer, and provide therapeutic and diagnostic clues. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4850. doi:10.1158/1538-7445.AM2011-4850
http://microarrays.nki.nl/ from Gene Expression Profiles of Primary Breast Carcinomas from Patients at High Risk for Local Recurrence after Breast-Conserving Therapy (2023)

http://microarrays.nki.nl/ from Gene Expression Profiles of Primary Breast Carcinomas from Patients at High Risk for Local Recurrence after Breast-Conserving Therapy
Bacteriophage λ RexA and RexB Functions Assist the Transition from Lysogeny to Lytic Growth (2021)

Summary The CI and Cro repressors of bacteriophage λ create a bistable switch between lysogenic and lytic growth. In λ lysogens, CI repressor expressed from the P RM promoter blocks expression of the lytic promoters P L and P R to allow stable maintenance of the lysogenic state. When lysogens are induced, CI repressor is inactivated and Cro repressor is expressed from the lytic P R promoter. Cro repressor blocks P RM transcription and CI repressor synthesis to ensure that the lytic state proceeds. RexA and RexB proteins, like CI, are expressed from the P RM promoter in λ lysogens; RexB is also expressed from a second promoter, P LIT , embedded in rexA. Here we show that RexA binds CI repressor and assists the transition from lysogenic to lytic growth, using both intact lysogens and defective prophages with reporter genes under control of the lytic P L and P R promoters. Once lytic growth begins, if the bistable switch does return to the immune state, RexA expression lessens the probability that it will remain there, thus stabilizing the lytic state and activation of the lytic P L and P R promoters. RexB modulates the effect of RexA and may also help establish phage DNA replication as lytic growth ensues.
Complete Genome Sequence of Methanolinea tarda NOBI-1 T , a Hydrogenotrophic Methanogen Isolated from Methanogenic Digester Sludge (2014)

Here, we report a 2.0-Mb complete genome sequence of Methanolinea tarda NOBI-1(T), a methanogenic archaeon isolated from an anaerobic digested sludge. This is the first genome report of the genus Methanolinea isolate belonging to the family Methanoregulaceae, a recently proposed novel family within the order Methanomicrobiales.
Search for Pair Production of a Heavy Up-Type Quark Decaying to aWBoson and abQuark in thelepton+jetsChannel with the ATLAS Detector (2012)

A search is presented for production of a heavy up-type quark (t') together with its antiparticle, assuming subsequent decay to a W boson and a b quark, t't[over ¯]'→W(+)bW(-)b[over ¯]. The search is based on 1.04 fb(-1) of proton-proton collisions at √[s]=7 TeV collected by the ATLAS detector at the CERN Large Hadron Collider. Data are analyzed in the lepton+jets final state, characterized by a high transverse momentum isolated electron or muon, high missing transverse momentum, and at least three jets. No significant excess of events above the background expectation is observed. A 95% C.L. lower limit of 404 GeV is set for the mass of the t' quark.
Some experiments with array data collected in actual urban and suburban environments (2002)

We compare the performance of several algorithms for signal separation based on actual mobile cellular radio data. The data were collected by base stations in two different environments: using an eight element linear array on a hillside overlooking a suburban area, and using a four element square array at the top of a ten story building in a dense urban area. Calibration data were available for one of the arrays used for the suburban data, allowing for performance comparisons between DOA-based and blind signal separators. Experiments were conducted with three different types of signal waveforms: sinewaves, simple FM waveforms, and /spl pi//4-DQPSK signals, each of which necessitated the use of a different performance metric. We focus on the results obtained for cases where the data were approximately low rank, with little delay spread (although not all data sets from the urban environment were of this type).