gebhart/patrepeval huggingface dataset:
Effects of Carbonyl Bond, Metal Cluster Dissociation, and Evaporation Rates on Predictions of Nanotube Production in High-Pressure Carbon Monoxide (2003)

The high-pressure carbon monoxide (HiPco) process for producing single-wall carbon nanotubes (SWNTs) uses iron pentacarbonyl as the source of iron for catalyzing the Boudouard reaction. Attempts using nickel tetracarbonyl led to no production of SWNTs. This paper discusses simulations at a constant condition of 1300 K and 30 atm in which the chemical rate equations are solved for different reaction schemes. A lumped cluster model is developed to limit the number of species in the models, yet it includes fairly large clusters. Reaction rate coefficients in these schemes are based on bond energies of iron and nickel species and on estimates of chemical rates for formation of SWNTs. SWNT growth is measured by the conformation of CO2. It is shown that the production of CO2 is significantly greater for FeCO because of its lower bond energy as compared with that of NiCO. It is also shown that the dissociation and evaporation rates of atoms from small metal clusters have a significant effect on CO2 production. A high rate of evaporation leads to a smaller number of metal clusters available to catalyze the Boudouard reaction. This suggests that if CO reacts with metal clusters and removes atoms from them by forming MeCO, this has the effect of enhancing the evaporation rate and reducing SWNT production. The study also investigates some other reactions in the model that have a less dramatic influence.
Optical gate action of a molecular thin film probed with femtosecond near-field optical microscopy (2000)

We have combined a near-field scanning optical microscope with a two-color time-resolved pump–probe measurement system. The sample was a molecular thin film that revealed an excitonic resonance and also had a characteristic domain structure. The measurement system has a noise-equivalent transmittance change as small as 5.0×10−5 for a probe pulse with an intensity of 30 nW, which allows us to detect an optical gate action of a single domain. The results suggest that the film composition is uniform over a distance of several microns while it may vary on a greater scale.
Histamine and histamine H1- and H2-receptor antagonists in acute inflammation (1980)

Review Article| February 01 1980 Histamine and histamine H1- and H2-receptor antagonists in acute inflammation D. A. A. OWEN; D. A. A. OWEN 1Department of Pharmacology, The Research Institute, Smith Kline and French Laboratories Ltd., Welwyn Garden City, Herts., U.K. Search for other works by this author on: This Site PubMed Google Scholar D. F. WOODWARD D. F. WOODWARD 1Department of Pharmacology, The Research Institute, Smith Kline and French Laboratories Ltd., Welwyn Garden City, Herts., U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1980) 8 (1): 150–155. https://doi.org/10.1042/bst0080150 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation D. A. A. OWEN, D. F. WOODWARD; Histamine and histamine H1- and H2-receptor antagonists in acute inflammation. Biochem Soc Trans 1 February 1980; 8 (1): 150–155. doi: https://doi.org/10.1042/bst0080150 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1980 Biochemical Society1980 Article PDF first page preview Close Modal You do not currently have access to this content.
Rational Synthesis of Contra-Thermodynamic Spiroacetals by Reductive Cyclizations (2004)

A synthesis of spiroacetals was developed using a reductive cyclization strategy that leads stereoselectively to spiroacetals with a single anomeric stabilization. The method begins with the synthesis of spiro ortho esters. The ortho ester is converted to a cyano acetal. Reductive lithiation of the cyano acetal generates an axial dialkoxylithium reagent, and intramolecular cyclization produces a new ring with retention of configuration. The strategy is convergent and produces complex spiro acetals in only a few steps. The method will be useful in the synthesis of natural products and will facilitate the synthesis of previously inaccessible contra-thermodynamic acetals.
Novel CXCL13 transgenic mouse: inflammation drives pathogenic effect of CXCL13 in experimental myasthenia gravis (2016)

Abnormal overexpression of CXCL13 is observed in many inflamed tissues and in particular in autoimmune diseases. Myasthenia gravis (MG) is a neuromuscular disease mainly mediated by anti-acetylcholine receptor autoantibodies. Thymic hyperplasia characterized by ectopic germinal centers (GCs) is a common feature in MG and is correlated with high levels of anti-AChR antibodies. We previously showed that the B-cell chemoattractant, CXCL13 is overexpressed by thymic epithelial cells in MG patients. We hypothesized that abnormal CXCL13 expression by the thymic epithelium triggered B-cell recruitment in MG. We therefore created a novel transgenic (Tg) mouse with a keratin 5 driven CXCL13 expression. The thymus of Tg mice overexpressed CXCL13 but did not trigger B-cell recruitment. However, in inflammatory conditions, induced by Poly(I:C), B cells strongly migrated to the thymus. Tg mice were also more susceptible to experimental autoimmune MG (EAMG) with stronger clinical signs, higher titers of anti-AChR antibodies, increased thymic B cells, and the development of germinal center-like structures. Consequently, this mouse model finally mimics the thymic pathology observed in human MG. Our data also demonstrated that inflammation is mandatory to reveal CXCL13 ability to recruit B cells and to induce tertiary lymphoid organ development.
ChemInform Abstract: Vinylogous Mannich Reactions. The Asymmetric Total Synthesis of (+)‐ Croomine. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
PEDS6: Virtual Anatomic Fit Study of PediaFlow Implantable VAD in Infants (4 Kg To 8 Kg) (2022)

Study: Because of the limited anatomic space available for an implantable VAD in infants, anatomic compatibility in infants is a critical design challenge. Unfortunately, there is limited anatomic data available for infants in the first six months of life. Yet the weight of the child nearly doubles during this period (4 kg to 8 kg for the 50 percentile). Therefore the goals of this research was to create a broad 3D anatomic database for the infant, derived from a limited set of serial CT scans of infants (4 kg – 8 kg) and to conduct a virtual fit study of the PediaFlow PF5 pediatric VAD, including inflow and outflow cannula. Methods: The series of axial images and two orthogonal images of 4 kg and 8 kg infants were imported into commercially available reconstruction software (Mimics) to create a 3-D surface model of the chest cavity. The clipping tool in Mimics was used to perform qualitative validation on two patients to assess the accuracy of the reference models for the database. The tool allowed the superimposition of axial, coronal, and sagittal CT imaging views onto 3D models, as shown in Figure 1. Interpolation of anatomic data from two reference patients resulted in an animation of the growth of the thoracic cavity and internal organs from 4 kg to 8 kg. Results: Figure 2 displays the virtual fitting of the PediaFlow PF5 in 5 intermediate anatomic models interpolated between 4 kg and 8 kg. Based on this analysis, we can appreciate the lower limit of patients for whom the PediaFlow and cannula can be fully implanted. Conclusion: Three-dimensional anatomic data for virtual fit studies in infants is limited. This study produced a scalable 3D model, derived from two reference CT scan data of two patients, that can be used for virtual fit studies, and can also be exported for 3D printing and 4D reconstruction. Figure 1. Qualitative validation was performed on the reconstructed anatomy of a 4-day-old patient infant. Figure 2. Results of virtual fit studies in 5 different anatomic models
Photochemical Activation of a Metal–Organic Framework to Reveal Functionality (2010)

„Blitzschnell“ zu neuen MOFs: In einer ungewöhnlichen postsynthetischen Entschützungsreaktion wurden zwei hochporöse Metall-organische Gerüste (MOFs) durch Bestrahlung mit UV-Licht in MOFs mit freien Hydroxy- und Catecholgruppen überführt (siehe Schema). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Energy-Eﬃcient Management of Campus PCs (2012)

Energy consumption has become a key challenge in the last few years. According to several studies [1, 2], the Information and Communication Technology (ICT) sector alone is responsible of a percentage which varies widely from 2% to 10% of the worldwide energy consumption, and several projects, both from industries and universities, are trying to reduce the power consumption of electronic devices.
Parallel Ping-Pong: Demonstrating Parallel Interaction through Multiple Bodies by a Single User (2021)

We explore a “Parallel Interaction”, where a user controls several bodies concurrently. To demonstrate this type of interaction we developed “Parallel Ping-Pong”. The user plays ping-pong by controlling 2 robot arms with a Virtual Reality (VR) controller, and while looking from the viewpoint of one of the 2 robot arms with a Head Mounted Display (HMD). The HMD view switches between the 2 robot arms’ viewpoints according to the ping-pong ball position and direction. To keep the sense of agency over the robot arms (hindered by the system latency), the robot arms calculate the balls’ paths and position themselves to hit the balls back; all while integrating the controller motion. Throughout this demonstration, we investigate a real-life design of Parallel Interaction with multiple bodies by a single user.
Relationship of endoscopic lesions of the renal papilla with type of renal stone and 24 h urine analysis (2020)

There are certain specific relationships between the different types of papillary calcifications that were endoscopically detected with stone chemistry and urine analysis. COD and CP stones were associated with endoscopic tubular calcifications and papillary craters. Hypercalciuria was associated with tubular calcification, and hypocitraturia was associated with Randall's plaque.
Inorganic capping layers in advanced photosensitive polymer based RDL processes: processing and reliability (2023)

In this work, thin inorganic ALD-deposited capping layers are integrated into polymer-based redistribution layer (RDL) processes with 2–4 <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$\mu \mathrm{m}$</tex> line/space. The primary objective of enhanced reliability is shown, with secondary process improvements detailed. Impact and respective mitigation on Lithography process reviewed and the introduction of the capping etch are further detailed.
Abstract 2323: ZGGS18, a bispecific drug candidate of anti-VEGF and TGFbeta-trap, inhibiting tumor proliferation and improving tumor microenvironment with I/O therapy (2023)

Abstract ZGGS18 is a bifunctional fusion protein targeting both human vascular endothelial growth factor (VEGF) and transforming growth factor-β (TGF-β), which consist of a monoclonal antibody against VEGF and an engineered extracellular domain of TGF-β receptor II (TGF-βRII ECD). In vitro studies show ZGGS18 specifically and simultaneously binding towards various VEGFs and capturing different TGF-β isoforms by trap domains that play a synergistic role to block signaling of VEGF/TGF-β with their receptors. For instance, ZGGS18 inhibits human VEGF121 and 165 induced HUVEC proliferation; ZGGS18 also neutralizes TGF-β1 and -β3 related growth arrest of HT-2 cells. Further studies show that ZGGS18 does not induce ADCC- or CDC-dependent killing tumor cells expressing two soluble targets, suggesting its binding affinities towards Fc-gamma and complement C1q receptors without effector functions. These results support functional depletion of VEGF/TGF-β in tumor microenvironment (TME) by ZGGS18 essentially for its MOA to inhibit tumor growth. A dose-dependent in vivo anti-tumor efficacy of ZGGS18 (1, 3 and 15 mg/kg) has been found in PBMC humanized H460 lung cancer xenograft model. In addition, ZGGS18 has enhanced efficacies to kill tumor growth in MC38 xenograft models when it is combined with anti-PD-1 antibodies (keytruda), support the improvement of TME for I/O reagents by ZGGS18 in cooperation with its role in anti-proliferation and anti-angiogenesis. Toxicity and safety pharmacology studies with weekly repeat doses for four weeks in cynomolgus monkeys indicate that ZGGS18 is well tolerated over the dose range 13, 40 and 120 mg/kg without obviously toxic or adverse effects (NOAEL =120 mg/kg). PK/TK analyses indicate that ZGG18 has a prolonged half-life in plasma, attribute to its human neonatal Fc receptor (FcRn) binding and pH-dependent interaction for mAb recycling. The IND application of ZGGS18 has been approved by both FDA and Chinese NMPA for clinical trials in treatment of advanced tumors as monotherapy and/or in combined with PD-1/PD-L1 based I/O therapies. Citation Format: Ruifeng Liu, Alfonso Suarez, Tyler Liban, Bin Zhang, Tongcheng Dai, Margaret Karow, Jackie Sheng, Zelin Sheng, Binhua Lv, Bing Zhu. ZGGS18, a bispecific drug candidate of anti-VEGF and TGFbeta-trap, inhibiting tumor proliferation and improving tumor microenvironment with I/O therapy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 2323.
A Robust Music Searching Method Using an Audio Signal Query Received in the Real World (2003)

あらまし 実環境で収録された楽曲の断片をキーとし,膨大な楽曲データからそれと同一の楽曲を探索する手 法を提案する.本手法は,時系列探索,すなわち,ある信号の断片がそれとは別の長時間の信号のどの時点にあ るかを探索するという枠組みに基づく.時系列探索についてこれまで,時系列アクティブ探索法など高速性に主 眼をおいた手法が提案されているが,実環境で収録された音のように,様々なひずみを含んだ信号を精度良く探 索する手法については検討されていなかった.本手法の基本的なアイデアは,時間周波数空間上で局所領域ごと に正規化を行った後,機器特性や環境雑音などによるひずみに対して頑健な部分空間に射影して照合を行うとい うものである.本手法を用いて,実環境でマイクや PHS で収録した 10 秒の音響信号の断片が,116 時間分の CD 品質の蓄積信号のどの曲のどの時刻に対応するかを調べる課題について実験を行ったところ,単純なパワー による正規化とスペクトル照合を用いた場合に 12.8%であった探索精度が,71.2%にまで改善し,本手法の有効 性が確認された.本手法により,様々なひずみに対して頑健な音響信号探索が可能になると考えられる. キーワード 音響信号探索,正規化,部分空間,ノイズ,検索
Characteristics of Hb-Vesicles and Encapsulation Procedure (1994)

The performance of Hb-vesicles depends on the weight ratio of Hb to lipid ([Hb]/[Lipid]). This value is improved by lowering the number of bilayer membrane of the vesicle and raising the concentration of Hb in the interior of the vesicle. Maximum [Hb]/[Lipid] ratio was obtained at ca. pH 7, that would relate to the isoelectric point (pI) of Hb at 25 degrees C. On the other hand, the [Hb]/[Lipid] ratio decreased with ionic strength and increased with lowering temperature. The Hb-vesicles encapsulating 40 g/dl Hb with only one bilayer membrane were isolated by using the difference in the density of the vesicles.
Object recognition for an intelligent room (2002)

Intelligent rooms equipped with video cameras can exhibit compelling behaviors, many of which depend on object recognition. Unfortunately, object recognition algorithms are rarely written with a normal consumer in mind, leading to programs that would be impractical to use for a typical person. These impracticalities include speed of execution, elaborate training rituals, and setting adjustable parameters. We present an algorithm that can be trained with only a few images of the object, that requires only two parameters to be set, and that runs at 0.7 Hz on a normal PC with a normal color camera. The algorithm represents an object's features as small, quantized edge templates, and it represents the object's geometry with kernels. The Hough kernels implement a variant of the generalized Hough transform using simple, 2D image correlation. The algorithm also uses color information to eliminate parts of the image from consideration. We give our results in terms of ROC curves for recognizing a computer keyboard with partial occlusion and background clutter. Even with two hands occluding the keyboard, the detection rate is 0.885 with a false alarm rate of 0.03.
Author Correction: Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation (2022)

LPS), by subcutaneous injection, with PBS or 0.75 mg kg -1 of porcine CSF-1 fused to the Fc region of porcine IgG1a (generated by David Hume), prior to cull on day 5" in the HTML and PDF versions of the article.
Another look at HMQV (2007)

The HMQV protocols are 'hashed variants' of the MQV key agreement protocols. They were introduced at CRYPTO 2005 by Krawczyk, who claimed that the HMQV protocols have very significant advantages over their MQV counterparts: (i) security proofs under reasonable assumptions in the (extended) Canetti-Krawczyk model for key exchange; and (ii) superior performance in some situations. In this paper we demonstrate that the HMQV protocols are insecure by presenting realistic attacks in the Canetti-Krawczyk model that recover a victim's static private key. We propose HMQV-1, patched versions of the HMQV protocols that resists our attacks (but do not have any performance advantages over MQV). We also identify some fallacies in the security proofs for HMQV, critique the security model, and raise some questions about the assurances that proofs in this model can provide.
Effect of the conditions of anodizing on the morphology of nanotitania (2017)

The effect the current density, treatment time, surface pretreatment, and electrolyte composition have on the morphology of titania obtained via electrochemical treatment in such ionic liquids (ILs) as 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide [BMIM][NTf2] and 1-butyl-3-methylimidazolium chloride [BMIM]Cl is studied. The anodic formation of titania nanostructures in the form of nanotubes or nanorods is found to occur in times of up to 100 s. The role of water in the formation of these titania nanostructures is shown. Pretreatment has no effect on the morphology of the formed oxide. The formation of products that are poorly soluble in ILs (e.g., hydrated oxides) results in the emergence of a layer partially covering the open parts of nanotubes, preventing their further growth.
Reactive MBE growth of GaN and GaN: H on GaN/SiC substrates (1997)

Reactive N and H, created using rf plasma sources, were used to grow undoped GaN along with p-type GaN:Mg and p-type GaN:Mg:H thin films. By comparing the optical emission spectra from several rf sources with observed GaN grow rates, we deduce that nitrogen atoms and I stpositive series nitrogen molecules (3.95 eV binding energy) are the reactive species responsible for GaN film growth. A Mg ground state acceptor binding energy of about 224 meV was determined from low temperature photoluminescence (PL) experiments for both p-type GaN:Mg and p-type GaN:Mg:H films.
Influence of compound structure on affinity, sequence selectivity, and mode of binding to DNA for unfused aromatic dications related to furamidine (2002)

In the course of a program aimed at developing sequence-specific gene-regulatory small organic molecules, we have investigated the DNA interactions of a new series of nine diphenylfuran dications related to the antiparasitic drug furamidine (DB75). Two types of structural modifications were tested: the terminal amidine groups of DB75 were shifted from the para to the meta position, and the amidines were replaced with imidazoline or dimethyl-imidazoline groups, to test the importance of both the position and nature of positively charged groups on DNA interactions. The interactions of these compounds with DNA and oligonucleotides were studied by a combination of biochemical and biophysical techniques. Absorption and CD measurements suggested that the drugs bind differently to AT and GC sequences in DNA. The para-para dications, like DB75, bind into the minor groove of poly(dAT)(2) and intercalate between the base pairs of poly(dGC)(2), as revealed by electric linear dichroism experiments. In contrast, the meta-meta compounds exhibit a high tendency to intercalate into DNA whatever the target sequence. The lack of sequence selectivity of the meta-meta compounds containing amidines or dimethyl-imidazoline groups was also evident from DNase I footprinting and surface plasmon resonance (SPR) experiments. Accurate binding measurements using the BIAcore SPR method revealed that all nine compounds bind with similar affinity to an immobilized GC sequence DNA hairpin but exhibit very distinct affinities for the corresponding AT hairpin oligonucleotide. The minor groove-binding para-para compounds have a high specificity for AT sequences. The biophysical data clearly indicate that shifting the cationic substituents from the para to the meta position results in a loss of specificity and change in binding mode. The strong AT selectivity of the para-para compounds was independently confirmed by DNase I footprinting experiments performed with a range of DNA restrictions fragments. In terms of AT selectivity, the compounds rank in the order para-para > para-meta > meta-meta. The para dications bind preferentially to sequences containing four contiguous AT base pairs. Additional footprinting experiments with substrates containing the 16 possible [A.T](4) blocks indicated that the presence of a TpA step within an [A.T] (4) block generally reduces the extent of binding. The diverse methods, from footprinting to SPR to dichroism, provide a consistent model for the interactions of the diphenylfuran dications with DNA of different sequences. Altogether, the results attest unequivocally that the binding mode for unfused aromatic cations can change completely depending on substituent position and DNA sequence. These data provide a rationale to explain the relationships between sequence selectivity and mode of binding to DNA for unfused aromatic dications related to furamidine.
Numerical predictions of oscillatory combustion in reactive multilayers (1999)

Current analytical models and recent experimental studies assume that exothermic formation reactions self-propagate in multilayer foils with steady temperature and composition profiles and uniform velocities. The numerical study presented here shows that in addition to steady propagation, oscillatory combustion can also exist in certain parameter regimes. The oscillatory regimes are characterized by superadiabatic temperature excursions and large variations in the reaction zone width, the flame thermal width, and the instantaneous flame velocity. The magnitudes of the oscillations are shown to increase as bilayer period decreases, as premixing in the as-deposited state increases, and as ambient temperature decreases.