gebhart/patrepeval huggingface dataset:
Medial unicompartmental arthroplasty after failed high tibial steotomy (2001)

Satisfactory selection criteria are essential for the successful outcome of unicompartmental knee arthroplasty (UCA). We report the frequency of revision of the Oxford medial unicompartmental arthroplasty in knees previously treated for anteromedial osteoarthritis by high tibial osteotomy (HTO). The combined results from three sources were used to allow statistical analysis of this uncommon subgroup. In the combined series of 631 knees (507 patients) which had medial unicompartmental replacement, 613 were primary procedures and 18 were for a failed HTO. The mean follow-up times of the two groups were similar (5.8 years and 5.4 years, respectively). At review, 19 (3.1%) of the primary procedures and five (27.8%) of those undertaken for a failed HTO had been revised to total knee replacement. Survival analysis revealed the ten-year cumulative survivals to be 96% and 66%, respectively. The log-rank comparison of these survivals revealed a highly significant difference (p &lt; 0.0001). We recommend that the Oxford UCA should not be used in knees which have previously undergone an HTO.
Embryonic Consequences of Abnormal Folate Transport: Impact on Congenital Heart Defects (2007)

Recent human epidemiological studies have demonstrated that maternal periconceptional supplementation with folic acid is associated with a significant risk reduction for several complex birth defects, including spina bifida and other neural tube defects, cleft lip and palate, and conotruncal heart defects. To better understand the underlying mechanisms, we have used the folate receptor (Folbp1) knockout mouse as a model for studying the role of folate supplementation in the prevention of congenital heart defects. Folbp1 nullizygous embryos receiving insufficient folate to support normal development present with septation defects of the outflow tract, similar to those observed following cardiac neural crest cell (NCC) ablation. These phenotypic changes include: ventricular septal defects, double‐outlet right ventricle, persistent truncus arteriosus, anomalous aortic arch arteries, and abnormal looping of the heart. There are notable changes in these embryos at both the molecular and cellular levels. Results from DNA microarray studies revealed a significant alteration in the expression of key regulators of NCC migration, for genes related to reactive oxidative stress, and highlighted the importance of genes in the Wnt signaling and Shh pathways. At the cellular level, the data obtained from this mouse model suggest that many of the underlying defects can be traced back to increased apoptosis in cardiac NCC precursors of Folbp1 nullizygotes. High dose maternal folinic acid supplementation restores normal patterns of gene expression and rescues the normal cardiac phenotype. Supported in part by NIH grant HL66398 and The Texas Institute for Genomic Medicine
Corrosion of Modular Junctions in Femoral and Acetabular Components for Hip Arthroplasty and Its Local and Systemic Effects (2015)

This paper reviews findings of previous and ongoing studies in our laboratories concerning the nature of corrosion in femoral and acetabular component modular junctions and its local and potential systemic effects. Corrosion of head-neck and neck-stem junctions generates ionic and particulate metallic products with the potential for adverse local tissue response, including a particle-induced macrophage response and a lymphocyte-dominated response to cobalt or chromium complexes resulting in widespread necrosis of the periprosthetic tissues. In addition to local effects, both particulate corrosion products and metallic ionic complexes can disseminate widely via lymphatic and hematogenous transport to remote organs where their long-term effect are incompletely understood.
Neural Network Simulation of Somatosensory Representational Plasticity (1989)

The brain represents the skin surface as a topographic map in the somatosensory cortex. This map has been shown experimentally to be modifiable in a use-dependent fashion throughout life. We present a neural network simulation of the competitive dynamics underlying this cortical plasticity by detailed analysis of receptive field properties of model neurons during simulations of skin coactivation, cortical lesion, digit amputation and nerve section.
Behavorial modeling of WCDMA transceiver with VHDL-AMS language (2006)

International audience
(Invited) Beyond the Highs and Lows: A Selectively Colorful Yet Chilly Perspective on the Future of Dielectrics in Nanoelectronic Devices (2018)

High-dielectric constant (high- k ) gate oxides and low-dielectric constant (low- k ) interlayer dielectrics (ILD) have dominated the nanoelectronic materials research scene over the past decade, but have recently reached a state of maturity and perhaps the limits of their scaling. Based on this, one may ponder the direction of nanoelectronic dielectric research and the future of the field. However, as we will clarify, the well has fortunately not yet run dry! In this address, we seek to illustrate that high- k gate oxides and low- k ILDs represent just a small fraction of the numerous dielectric materials utilized in nanoelectronic products and that numerous new applications for dielectric materials are emerging as the industry transistions to novel patterning schemes and prepares for life post CMOS scaling. We will begin by briefly exploring the entirety of dielectric materials utilized in advanced nanoelectronic products with a particular focus on often ignored etch stopping, diffusion barrier, and passivation dielectrics and their more specialized requirements relative to high- k and low- k dielectrics. We will then transition to examining the various novel pitch division schemes being developed to cope with the delay of EUV lithography and the abundant new dielectric material applications these schemes create. We will specifically focus on the various new spacer and hard mask dielectrics that pitch division requires, their colorful selectivity requirements, and suggest future research needed to enable even more exotic patterning schemes. We will further examine how what was once old can become new again and specifically explore how both high- k and low- k dielectrics are being utilized to fill the needs of future beyond CMOS devices. In particular, the application of high- k and low- k dielectrics in novel resistive switching, magnetic, and nano-electro-mechanical device and sensor applications will be surveyed along with the research needed to extend these materials into even more diverse applications. We will conclude by reviewing the unique obstacles that dielectric materials present for the realization of advanced cryogenic quantum computing architectures and the necessary associated research vectors to prevent dielectrics from becoming quantum computing’s Achilles heel.
Computer simulation for design of depth encoding multicrystal detector for PET (2003)

A detector proposed by Murayama et al. (IEEE Trans. Nucl. Sci., vol. 45, no.3, p. 1152-7, 1998) for detection of depth-of-interaction (DOI) in PET consists of three-dimensionally arranged crystal blocks with proper optical reflectors and is coupled to an array of photomultiplier tubes. This detector has a great advantage in easiness and cost in fabrication. The authors built a simulator of such a detector which allows them to find appropriate values of parameters such as optical properties of crystal or detector unit geometry before making detectors actually. The simulator is based on the Monte Carlo method which traces the migration of optical photons generated by interaction of a gamma ray with crystal. First, the simulator performance was validated by comparing with the experimental data obtained with some prototype detectors. Then, on some parameters including refractive index of crystal, detector geometry, and light yield per interaction, appropriate values were investigated for accurate block discrimination from PMT output signals.
Flexible, Dopant Free a-Si:H Solar Cell (2019)

Dopant free thin film solar cells with the common structure of ZnO:Al / MoO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> / a- Si:H / LiF / Al are fabricated directly on flexible, transparent substrates. All the layers, except the a-Si:H layer, are deposited by simple, low temperature physical vapour deposition methods. An open circuit voltage of 0.764V and a short circuit current density of 11.31 mA/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> are measured under AM1.5 irradiance. The proof of concept for flexible, dopant free a- Si:H solar cell demonstrated here is a step forward towards processing cost-effective, flexible and lightweight thin film solar cells.
Control Mechanism for Carbon‐Chain Length in Polyunsaturated Fatty‐Acid Synthases (2019)

Abstract Polyunsaturated fatty acids (PUFAs) such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are essential fatty acids. PUFA synthases are composed of three to four subunits and each create a specific PUFA without undesirable byproducts. However, detailed biosynthetic mechanisms for controlling final product profiles have been obscure. Here, the bacterial DHA and EPA synthases were carefully dissected by in vivo and in vitro experiments. In vitro analysis with two KS domains (KS A and KS C ) and acyl‐acyl carrier protein (ACP) substrates showed that KS A accepted short‐ to medium‐chain substrates while KS C accepted medium‐ to long‐chain substrates. Unexpectedly, condensation from C 18 to C 20 , the last elongation step in EPA biosynthesis, was catalyzed by KS A domains in both EPA and DHA synthases. Conversely, condensation from C 20 to C 22 , the last elongation step for DHA biosynthesis, was catalyzed by the KS C domain in DHA synthase. KS C domains therefore determine the chain lengths.
Passive and active acoustics using an autonomous wave glider (2012)

Abstract The recently developed wave glider has the potential to be an effective unmanned platform for acoustic applications. We present the results of a variety of experiments that quantify this potential. The radiated self‐noise of the autonomous platform is evaluated using an integrated passive acoustic recorder during a set of field trials off the coast of Hawaii. We present the radiated noise spectra from these trials to illustrate the dependence on hydrophone location and sea state. Using the same instrumentation, we demonstrate the ability of a modified wave glider to detect marine mammals using passive acoustic monitoring techniques. We also evaluate the performance of the wave glider operating as an active acoustic gateway, highlighting the potential of this platform to serve as a navigation reference and communications relay for scientific, industrial, and military subsea assets. To demonstrate the potential of the wave glider platform to support acoustic navigation, we assess the performance of time‐of‐flight range estimation and seafloor transponder localization. These tests were performed using commercial off‐the‐shelf acoustic positioning hardware integrated with the wave glider to illustrate that the low self‐noise of the wave glider makes it possible to achieve acoustic positioning performance similar to previously reported results. Finally, we show that the glider can operate as a station‐keeping surface communications gateway and provide recommendations for its use. © 2012 Wiley Periodicals, Inc.
Study of the conformation of cyclosporine in aqueous medium by means of monoclonal antibodies (1988)

The three-dimensional structure of the immunosuppressive cyclic peptide cyclosporine (Cs), determined in crystal by X-ray analysis and in solution in aprotic solvents by n.m.r., differs mainly by the orientation of the 7 carbon side chain of residue 1. Because of its poor solubility in water, the conformation of Cs in aqueous medium cannot be studied by n.m.r. methods, which require concentrations of the substance of the order of milligram/mL but can be analyzed by immunochemical methods in which concentrations in the nanogram/mL range are detected. In the present study, the ability of a series of monoclonal antibodies (McAbs) raised against Cs to recognize different parts of residue 1 of Cs was determined from the cross-reactivity of different Cs-analogues modified in residue 1. The results show that when Cs is dissolved in aqueous buffer, the terminal atoms of residue 1 side chain are not available for binding to antibodies recognizing the face of the molecule defined by residues 1, 2, 3, 10, 11, suggesting that the chain is probably folded back under the molecule, as observed in the crystal structure. Binding of McAbs to Cs was also affected by conformational modifications of the peptide ring that occur in some Cs-analogues. The results illustrate the potential of McAbs for probing the conformation of Cs-derivatives for which no structural data are available.
Perioperative haemostasis and coagulation management in cardiac surgery (2007)

Background and objectives: During the last decade many aspects of haemostasis and coagulation management greatly changed in cardiac surgery. On one side, new anti-platelet agents entered the market and became more and more widely used; on the other one, point-of-care monitoring tools are nowadays available for perioperative use. The present survey is aimed to investigate the perioperative haemostasis and coagulation management in European Cardiac Surgery Institutions. Methods: A questionnaire exploring different aspects of perioperative haemostasis and coagulation management was sent to 320 Cardiac Surgery Institutions in Europe. Results: 82 Institutions replied to the survey. Due to the poor quality of the data collection, 9 Institutions were excluded. A pool of 73 questionnaires coming from 24 different Countries was analyzed. Non-routine coagulation tests (antithrombin activity) are done in 34% of the Institutions before the operation and in 23% after the operation. Point-of-care tests are applied as a preoperative routine in 9.9% of the Institutions (thromboelastography, 5.7%; PFA-100, 1.4%; others, 2.8%) and in selected patients in 50% of the Institutions. Postoperative point-of-care test are applied in 17.9% of the Institutions (thromboelastography, 2.7%; PFA-100, 1.4%; others, 13.8%). Allogeneic blood products use widely differs among Institution: packed red cells are used in 47.5% of the patients (range 8%-90%), fresh frozen plasma in 29% (2%-100%) and platelets in 12.4% (0%-50%). Conclusions: Perioperative haemostasis and coagulation management is widely different among European Institutions. Point-of-care coagulation and platelet function tests are gaining a significant role. Transfusional policy appears strongly Institution-dependent.
Abstract 56: Growth Hormone Releasing Hormone Improves Sarcomere Relaxation and Calcium Decline in Cardiomyocyte From a Mouse Model of Heart Failure With Preserved Ejection Fraction (2016)

Heart failure with preserved ejection fraction (HFpEF) is characterized by impaired relaxation, ventricular stiffening and fibrosis. Growth hormone releasing hormone (GHRH) agonists reduce fibrosis in rat and swine models of ischemic myocardial injury. However, their effect on cardiomyocytes is not known. We hypothesized that activation of GHRH receptor signaling improves impaired cardiomyocyte relaxation in a mouse model of HFpEF. C57BL6N mice (n=4-5) were implanted with a mini-osmotic pump to deliver angiotensin-II (Ang-II: 0.8 mg/kg/day) for 4 weeks and received daily injections of GHRH-Agonist (GHRH-A [MR-409]: 100 μg/kg) or vehicle (DMSO+propylene-glycol). Cardiomyocytes were isolated and calcium and sarcomere shortening assessed. Ang-II-treated cardiomyocytes exhibited reduced sarcomere length, indicating an inability to completely relax, despite lower resting calcium. These cardiomyocytes also exhibited impaired ability to contract with no changes in calcium transient amplitude, deficient relaxation and delayed calcium decay. MR-409 treatment restored resting calcium and resting sarcomere length; improved sarcomere shortening and completely abrogated Ang-II-induced delay in calcium decline and relaxation (see figure 1). Our findings demonstrate that chronic administration of Ang-II mediates structural and functional changes consistent with HFpEF and suggest that activation of the GHRH receptor signaling pathways prevents HFpEF-associated cardiomyocyte performance alterations.
Effects of insulin-like growth factors I and II on tumour-necrosis-factor-a-induced apoptosis in early murine embryos (2002)

The proposition that members of the insulin-like growth factor superfamily act as rescue factors from apoptosis in murine preimplantation embryos was tested. The cytokine tumour necrosis factor alpha (TNFalpha) was used to induce apoptosis. Zygotes were cultured for 5 days to the blastocyst stage in the presence or absence of TNFalpha and in the presence or absence of the insulin-like growth factors, IGF-I or IGF-II. Tumour necrosis factor alpha significantly increased the percentage of apoptotic cells and reduced the total cell count in Day 5 blastocysts. When IGF-I or IGF-II were added to the culture medium in the presence of TNFalpha, the cell number and apoptotic dead cell index (DCI) were restored to control values. Insulin-like growth factor-I alone had a greater effect on total cell number than IGF-II alone, but did not significantly decrease the apoptotic DCI. In contrast, IGF-II significantly reduced the number of apoptotic cells. This study shows that IGFs may play a role as apoptotic survival factors in the early mouse embryo.
Efficient Parameter Optimization by Applying Estimation Error Reduction to Design of Experiments for Image Processing (2012)

An efficient method for optimizing the parameters used for image processing is described that applies estimation error reduction to design of experiments (DOE). The traditional DOE optimization method is used to estimate the evaluation scores of all parameter sets and to rank them using a small number of actual scores. Because the search for the optimal parameter set is done in the order of the estimated scores for all parameter sets, the ranking accuracy, which strongly depends on the estimation error, is important. We introduce a function for reducing the estimation errors for the higher ranked parameter sets. The proposed parameter optimization method was evaluated by applying it to parameter optimization for industrial image defect area extraction. Evaluation using three datasets showed that the parameter sets selected by the proposed method had close to the highest actual score and that the number of image processings was 1/57 that of a full search procedure.
Alkyl‐ und Alkylidin‐Komplexe des Rheniums (1989)

Wegen der Vielfalt seiner Oxidationsstufen ermöglicht das Element Rhenium die Fixierung zahlreicher Ligandentypen in stabilen Komplexen. Durch die Synthese von [Cp*ReClMe 3 ] ist jetzt die Reihe der Re v ‐Komplexe [Cp*ReCl n Me 4‐n ] komplett. Der Neopentyl‐Komplex 1 reagiert mit C 5 H 5 TiCl 3 zum paramagnetischen Carbin‐Komplex 2 , der sich glatt zum diamagnetischen Komplex 3 oxidieren läßt. 2 und 3 sind die ersten π‐Cyclopentadienyl‐Carbinkomplexe mit hohen Oxidationsstufen des Rheniums (Re VI bzw. Re VII ). Cp* = η 5 ‐C 5 (CH 3 ) 5 . magnified image
Formant-based technique for automatic filled-pause detection in spontaneous spoken english (2009)

Detection of filled pauses is a challenging research problem which has several practical applications. It can be used to evaluate the spoken fluency skills of the speaker, to improve the performance of automatic speech recognition systems or to predict the mental state of the speaker. This paper presents an algorithm for filled pause detection that is based on the premise that the vocal tract characteristics, and hence the formants, are stable during the production of a filled pause. The performance of the proposed algorithm is evaluated on real-life recordings of call center agents where the locations of the filled pauses are hand labeled. The proposed algorithm outperforms a standard cepstral stability based filled pause detection algorithm and a standard pitch-based detection technique.
Optimal Number Of Measurements For Compressed Sensing With Quadratically Decreasing Snr (2018)

Publication in the conference proceedings of EUSIPCO, Kos island, Greece, 2017
A Dual Inductor Current fed dc/dc converter with ZVS active clamping, for fuel cell based plant (2008)

The paper deals with dc / dc converter suitable to be coupled with fuel cells sources. The spreading of fuel cells has impelled a deep study of dc / dc converter structures properly designed to solve problems connected with the use of fuel cells as primary energy source. A good solution is represented by DIC (dual input inductor converter). The paper focuses on this kind of converter proposing a modification of the base structure in order to achieve ZVS operation. Moreover, in the paper, designing and dimensioning guidelines, for the proposed structure, are presented. Finally, a whole fuel cell based energy source has been simulated and simulation results are reported.
Functional organization of spectral receptive fields in the primary auditory cortex of the owl monkey (1999)

Recent experiments in the cat have demonstrated that several response parameters, including frequency tuning, intensity tuning, and FM selectivity, are spatially segregated across the isofrequency axis. To investigate whether a similar functional organization exists in the primate, we have studied the spatial distribution of pure-tone receptive field parameters across the primary auditory cortex (AI) in six owl monkeys (Aotus trivirgatus). The distributions of binaural interaction types and onset latency were also examined. Consistent with previous studies, the primary auditory cortex contained a clear cochleotopic organization. We demonstrate here that several other properties of the responses to tonal stimuli also showed nonrandom spatial distributions that were largely independent from each other. In particular, the sharpness of frequency tuning to pure tones, intensity tuning and sensitivity, response latency, and binaural interaction types all showed spatial variations that were independent from the representation of characteristic frequency and from each other. Statistical analysis confirmed that these organizations did not reflect random distributions. The overall organizational pattern of overlaying but independent functional maps that emerged was quite similar to that seen in AI of cats and, in general, appears to reflect a fundamental organization principle of primary sensory cortical fields.
Do patient and proxy agree? Long-term changes in multiple sclerosis physical impact and walking ability on patient-reported outcome scales (2014)

In the majority of the patient-proxy couples there was agreement. Proxies can serve as a valuable source of information, but caution remains essential when using scores from proxies.