gebhart/patrepeval huggingface dataset:
Improved transparency-nonlinearity trade-off with boroxine-based octupolar molecules (2004)

Over the last two decades, a substantial effort has been devoted to the design of molecules with enhanced NLO responses. It has become increasingly clear over recent years that multipolar structures offer challenging possibilities in this respect. In particular, the octupolar framework provides an interesting route towards enhanced NLO responses and improved nonlinearity-transparency trade-off. In this perspective, we have implemented an innovative route based on octupolar structures derived from the boroxine ring. By grafting three electron-donating appendices on the electron-deficient boroxine core, octupolar quasi-planar molecules displaying markedly improved nonlinearity-transparency trade-off, as compared to the prototypical octupole (TATB) or the extensively studied triazine derivatives, were designed. This route indeed led to octupolar molecules showing beta(0) values (from calculations and solution measurements) larger than that of TIATB while remaining blue-shifted by nearly 100 nm and totally transparent in the visible region. Combined experimental and theoretical investigations reveal that this behavior is related to a periphery-to-core intramolecular charge transfer phenomenon in relation with the low-aromaticity and electron-withdrawing character of the boroxine ring. This study opens a new route for molecular engineering of transparent octupolar derivatives for NLO, including the design of effective materials for SHG in the visible-blue region.
Validation of convection‐limited cooling of samples for freeze‐fracture electron microscopy (1991)

Rapid freezing is the most important step in sample preparation for freeze-fracture and other cryotechniques for electron microscopy. A simple heat transfer model is experimentally validated to show that convection from the cryogen to the specimen is the limiting step in rapid freezing of small samples [Biot modulus, (hd/k) less than 1] by measuring cooling rates in a variety of samples, materials, and cryogens. In comparison to the commonly accepted conduction-limited model, the convection-limited model predicts, and our experiments show, that cooling rates are proportional to the surface area to volume ratio, independent of the sample thermal conductivity, and inversely proportional to the product of sample density and heat capacity. We show that almost any material can be frozen at similar rates if the sample thickness, the cryogen, and the method and velocity of contact with cryogen are similar. Liquid ethane or propane cooled to liquid nitrogen temperature are shown to give the best results.
The coordinative decentralized control system based on local communications (2002)

Proposes a coordinative decentralized control system architecture (CODA) as a fault-tolerant industrial plant control system. The system can be reconfigured to adapt to its conditions and environment by the coordination of its controllers. To guarantee the appropriate coordination, coordination protocol was designed to be the rules of cooperation among the controllers. The coordination mechanism is a combination of intercontroller activity and intracontroller activity. To verify its coordinatability, a prototype of CODA was tested by simulation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Barley Phenolamides Effectively Scavenge Harmful Methylglyoxal In Vitro and in Mice (2023)

These findings suggest that barley phenolamides may have the potentials to be developed as alternative therapeutics to prevent the development of MGO-associated diabetes and diabetic complications.
RAPID SOLIDIFICATION PROCESSING OF INDIUM GALLIUM ANTIMONIDE ALLOYS (1987)

Solidification from the melt is an essential step in nearly all conventional processes to produce bulk materials for industrial applications. Rapid quenching from the liquid state at cooling rates of 102 to 106K/s or higher has developed into a new technology for processing novel materials. InxGa1 - xSb a ternary III-V compound semiconductor was synthesized by using the rapid spinning cup (RSC) technique. Several compositions of these alloys were batched and cast into ingots in evacuated sealed quartz tubes. These ingots were then melted and ejected onto a rapidly rotating copper disk. This resulted in the generation of flakes or powders depending on the rpm of the disk. Microstructural characterization of the flakes and powders was performed using XRD, SEM and TEM. Efforts were also made to measure the bulk resistivity of the annealed flakes to see the effect of annealing on ordering of the phases.
The role of Neurotransmitters in the Genesis of Uremic Encephalopathy (1984)

To classify the influence of neurotransmitters in the genesis of uremic encephalopathy we studied cerebrospinal fluid (CSF) and plasma (P) amino acid (AA) concentration, in patients undergoing various dialytic treatments (hemodialysis = HD, intermittent and continuous peritoneal dialysis = IPD and CAPD). HD causes a significant decrease in CSF/P ratios of branched chain AA (BCAA) and a significant increase in CSF Glycine/Valine ratio, suggesting an augmented brain uptake of Glycine at detriment of Valine. In IPD the general trend of Aromatic AA/BCAA ratio suggests a preferential transport of Aromatic AA through the blood brain barrier. The differences between IPD and HD are confirmed by data concerning metabolites of Serotonin and Dopamine: CSF concentrations of 5- Hydroxyindoleacetic acid and Homovanillic acid are low in HD but high in IPD. So, a reduced (in HD) and an increased (in IPD) activity of monoamine systems could be at the basis of some neurological disturbances appearing in uremia.
Genetic analysis of influenza B viruses isolated in Uganda during the 2009–2010 seasons (2013)

In general there was limited variation among the Ugandan isolates but they were interestingly closer to viruses from West and North Africa than from neighboring Kenya. Our isolates closely matched the World Health Organization recommended vaccines for the seasons.
Overcurrent Simulation Test for High-Temperature Superconducting Generator (2008)

A small high-temperature superconductor (HTS) coil was designed and tested at the General Electric Global Research Center to evaluate the overcurrent capability for the HTS generator rotor. The superconducting rotor coil is a layer-wound racetrack coil using the BSCCO 2223 conductor. Overcurrent simulation tests have been done to simulate the fault operation condition for the generator based on previous analysis work. The obtained data are used to evaluate the performance of the HTS material in generator applications.
Conjugated Oligoelectrolyte Electron Transport/Injection Layers for Organic Optoelectronic Devices (2008)

The function of a conjugated oligoelectrolyte (COE) as the electron transport layer (ETL) in polymer light emitting diodes is demonstrated. Current density−luminance−voltage characteristics demonstrate that insertion of the COE adjacent to an Al electrode yields higher device efficiencies than those obtained using the low work function cathode Ba. Furthermore, the temporal response of the electroluminescence is faster than that observed when using conjugated polyelectrolytes as the ETL. That COEs have better defined structures than their polymeric counterparts may make them more attractive materials for the fabrication of efficient PLEDs prepared by spin coating methods.
Glucose concentration during equine in vitro maturation alters mitochondrial function (2020)

The use of in vitro embryo production in the horse is increasing in clinical and research settings; however, protocols are yet to be optimised. Notably, the two most commonly used base media for in vitro maturation (IVM) supply glucose at markedly different concentrations: physiological (5.6 mM, M199) or supraphysiological (17 mM, DMEM/F-12). Exposure to high glucose has detrimental effects on oocytes and early embryos in many mammalian species, but the impact has not yet been examined in the horse. To address this, we compared the energy metabolism of equine COCs matured in M199-based maturation medium containing either 5.6 or 17 mM glucose, as well as expression of key genes in oocytes and cumulus cells. Oocytes were fertilised by ICSI and cultured. Analysis of spent medium revealed that COC glucose consumption and production of lactate and pyruvate were similar between treatments. However, the glycolytic index was decreased at 17 mM and analysis of mitochondrial function of COCs revealed that IVM in 17 mM glucose was associated with decreased ATP-coupled respiration and increased non-mitochondrial respiration compared to that for 5.6 mM glucose. We also found that the metabolic enzyme lactate dehydrogenase-A (LDHA) was downregulated in cumulus cells of oocytes that completed IVM in 17 mM glucose. There was no difference in maturation or blastocyst rates. These data indicate that COC mitochondrial function and gene expression are altered by high glucose concentration during IVM. Further work is needed to determine if these changes are associated with developmental changes in the resulting offspring.
An open-label, multiple ascending dose study of the anti-CTLA-4 antibody ipilimumab in viremic HIV patients (2018)

Expression of cytotoxic T-lymphocyte antigen 4 (CTLA-4), a negative regulator of T-cell function, is increased in chronic HIV-1 infection. It was hypothesized that CTLA-4 blockade may enhance immune response to HIV-1 and result in better control of viremia. This open-label, multiple ascending dose study (NCT03407105)-the first to examine ipilimumab in participants with HIV-1 infection-assessed the safety, tolerability, and pharmacokinetics of ipilimumab, as well as whether ipilimumab enhanced immune response to HIV-1 and improved control of viremia. Twenty-four participants received 2 or 4 doses of ipilimumab (0.1, 1, 3, or 5 mg/kg) every 28 days. No serious adverse events (AEs) or dose-limiting toxicities were reported; one participant discontinued ipilimumab for an AE of grade 2 facial palsy. Twenty participants (83.3%) had ≥1 AE; all but 1 were grade 1 or 2. Eight participants (33.3%) had potentially immune-related AEs (7 had grade 1 diarrhea not requiring corticosteroids; 1 who had diarrhea also had transient antinuclear antibody positivity; 1 had grade 2 facial palsy requiring corticosteroids). Two participants (8.3%), one each in the 0.1- and 1-mg/kg dose groups, had a decrease from baseline HIV-1 RNA of 0.85 and 1.36 log10 copies/mL. Fourteen participants (58.3%) had an increase from baseline HIV-1 RNA (mean, 0.87 log10 copies/mL; range, 0.59-1.29). Of these 14 participants, all but 1 were in the higher ipilimumab dose groups (3 or 5 mg/kg). No pattern was noted regarding change from baseline in CD4 or CD8 T cells; ex vivo assessments of immune response were precluded because of inadequate cell viability. Serum concentration data for ipilimumab showed biphasic disposition, with steady state reached by dose 3. Ipilimumab treatment was well tolerated and was associated with variations in HIV-1 RNA in excess of expected repeat measures in most participants, but these were not related to combination antiretroviral therapy status or CD4 counts. The mechanism(s) underlying the increased variation in HIV-1 RNA is unclear and needs further study.
Publisher's Note: Integrated nanoplasmonic quantum interfaces for room-temperature single-photon sources [Phys. Rev. B 96, 235151 (2017)] (2018)

Received 5 January 2018DOI:https://doi.org/10.1103/PhysRevB.97.039902©2018 American Physical SocietyPhysics Subject Headings (PhySH)Research AreasNanophotonicsPlasmonicsQuantum description of light-matter interactionSingle photon sourcesPhysical SystemsQuantum cavitiesTechniquesJaynes-Cummings modelQuantum theoryAtomic, Molecular & Optical
ChemInform Abstract: Enzyme‐Catalyzed Synthesis of Carbohydrates (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Validation of Novel Bifacial Photovoltaic Performance Model with 3D shading for Fixed-Tilt and Single-Axis Tracked Systems (2022)

Existing bifacial photovoltaic (PV) performance models fall primarily into two categories: (1) ray tracing models that capture complex shading but lack the computational efficiency required for optimization applications; and (2) view factor (VF) models that efficiently simulate energy transfer but rely on user-defined losses which neglect temporal variation in phenomena such as shading and electrical mismatch. Hybrid VF / ray tracing models selectively employ ray tracing while balancing computational efficiency. This paper describes the validation of a novel hybrid model, DUET, which combines a 3D VF model with deterministic ray-object intersections. The software provides 2D irradiance profiles and mismatch-inclusive current-voltage curves for each scale of components: from cells to the full array. Validation against open-access data from Denmark shows that DUET predicts bifacial energy yield at 0.76% and 0.65% lower than measured yield for fixed-tilt and horizontal single-axis tracked (HSAT) rows, respectively, over 3370 and 2731 daylight hours. Monthly relative error in bifacial energy ranges from < 1% to ~4.5% for both systems. The mean absolute error (MAE) in hourly bifacial power is 18.1 mW/Wp for fixed-tilt and 18.4 mW/Wp for HSAT. These errors fall below the lowest previously reported MAE for six software at the same field site by ~0.77 mW/Wp for fixed-tilt and ~1.1 mW/Wp for HSAT. Modelled average rear insolation agrees with pyranometer data within +4.4% for fixed-tilt and -0.76% for HSAT. For both configurations, rear irradiance MAE aligns with the lowest error previously reported for other software at the site.
Pro/Con debate: the calculation on calcium balance in dialysis lowers the dialysate calcium concentrations (pro part) (2009)

Prior to the advent of calcitriol therapy, haemodialysis (HD) patients were often in negative calcium (Ca) balance between dialyses because of severely impaired Ca absorption [1] that led to the recommendation of dialysate inlet Ca concentration (CdiCa++) 3.0–3.5 mEq/L, higher than plasma concentration [2]. Over the past 25 years since the advent of calcitriol, virtually all haemodialysis patients absorbed a substantial portion of dietary and phosphate binder calcium ingested between dialyses and yet CdiCa++ 3.0 mEq/L has continued to be widely used. The total Ca absorbed between dialyses (CaAbsT) must be removed by the dialyser (JdCaT) to achieve net zero Ca mass balance over the dialysis cycle and prevent chronic Ca overload that likely contributes to the high rate of vascular calcification in haemodialysis patients [3–5]. From this perspective, it follows that the CdiCa++ prescribed should result in neutral Ca mass balance and thus total Ca removed during dialysis (JdCa++), the sum of diffusive (JDiffCa++) and convective Ca++ (JConvCa++) removal, should equal CaAbs in accordance with
An Experimental Model of Adult-Onset Slip Progression in Isthmic Spondylolisthesis (2001)

Abstract Spondylolisthesis is defined as a slippage of a vertebral body on the one below. Isthmic spondylolisthesis, caused by stress fracture or a developmental anomaly at the pars interarticularis, is the most common type of lumbar spondylolisthesis with a 6% incidence in adults. Isthmic lumbar spondylolisthesis is a frequent cause of disabling low-back and leg pain. The goal of this study is to improve the quality of treatment of these patients.
An enclosed in-gel PCR amplification cassette with multi-target, multi-sample detection for platform molecular diagnostics (2013)

This work describes a self-contained, simple, disposable, and inexpensive gel capillary cassette for DNA amplification in near point of care settings. The cassette avoids the need for pumps or valves during raw sample delivery or polymerase chain reaction (PCR) amplification steps. The cassette contains capillary reaction units that can be stored at room temperature for up to 3 months. The current cassette configuration format simultaneously tests up to 16 patients for two or more targets, accommodates different sample types on the same cassette, has integrated positive and negative controls and allows flexibility for multiple geometries. PCR reagents in the cassette are desiccated to allow storage at room temperature with rehydration by raw sample at the time of testing. The sample is introduced to the cassette via a transfer pipette simply by capillary force. DNA amplification was carried out in a portable prototype instrument for PCR thermal cycling with fluorescence detection of amplified products by melt curve analysis (MCA). To demonstrate performance, raw genital swabs and urine were introduced to the same cassette to simultaneously detect four sexually transmitted infections. Herpes Simplex Viruses (HSV-1 and HSV-2) were detected from raw genital swabs. Ureaplasma urealyticum (UU) and Mycoplasma homonis (MH) were detected from raw urine. Results for multiple patients were obtained in as little as 50 min. This platform allows multiparameter clinical testing with a pre-assembled cassette that requires only the introduction of raw sample. Modification of the prototype device to accommodate larger cassettes will ultimately provide high throughput simultaneous testing of even larger numbers of samples for many different targets, as is required for some clinical applications. Combinations of wax and/or polymer cassettes holding capillary reaction units are feasible. The components of the cassette are suited to mass production and robotic assembly to produce a readily manufactured disposable reaction cassette that can be configured for disease-specific testing panels. Rapid testing with a disposable reaction cassette on an inexpensive instrument will enable on the spot evaluation of patients in the clinic for faster medical decision-making and more informed therapeutic choices.
Characterization of the capsaicin‐sensitive component of cyclophosphamide‐induced inflammation in the rat urinary bladder (1994)

1. Cyclophosphamide (CYP) (150 mg kg-1, i.p. 0.5-48 h before) caused a time-dependent plasma protein extravasation in the rat urinary bladder with the maximal extravasation occurring at between 2 and 4 h after administration of the drug. 2. Prior capsaicin desensitization of capsaicin-sensitive primary afferent neurones (CSPANs) (50 mg kg-1, s.c., 4 days before) resulted in approximately 50% inhibition of the magnitude of the extravasation response at the 2 h time-point. 3. Intraperitoneal (i.p.) pretreatment with the tachykinin NK1 receptor antagonist, RP 67,580 (0.44 mg kg-1) or the bradykinin B2 receptor antagonist, Hoe 140 (0.13 mg kg-1) had significant inhibitory effects, giving responses of 56 +/- 6% and 39 +/- 4% of the control extravasation response to CYP treatment after 2 h. Pretreatment with the tachykinin NK2 receptor antagonist, SR 48,968 (0.3 mg kg-1, i.p.), the histamine H1 receptor blocker, chlorpheniramine (10 mg kg-1, i.p.), the 5-HT receptor blocker, methysergide (6 mg kg-1, i.p.) or the cyclo-oxygenase inhibitor indomethacin (5 mg kg-1, i.p.) had no significant effect upon the development of the extravasation response at this same time-point. 4. In rat isolated urinary bladder strips, the active metabolite of CYP, acrolein (1-300 microM) produced a concentration-dependent contraction that was significantly reduced by in vitro capsaicin desensitization (10 microM for 15 min) indicating direct stimulation of CSPANs. CYP was without appreciable effect. 5. The effect of acrolein in vitro was significantly reduced by pretreatment of the bladder with a combination of tachykinin NK1 and NK2 receptor antagonists, RP 67,580 (3 microM) and SR 48,968 (1 microM). The dose-response curve to acrolein was also significantly inhibited by treatment with indomethacin (10 microM) and slightly affected by Hoe 140 (1 microM). 6. These findings demonstrate the contribution of CSPANs to the development of CYP-induced cystitis.Plasma protein extravasation involves activation of tachykinin NKI and bradykinin B2 receptors.Activation of CSPANs in the urinary bladder is likely to be due to the conversion of CYP into its active metabolite, acrolein, and not to a direct effect of CYP upon these nerve-endings.
The effect of soil surfactants on soil hydrological behavior, the plant growth environment, irrigation efficiency and water conservation (2010)

The effect of soil surfactants on soil hydrological behavior, the plant growth environment, irrigation efficiency and water conservation Soil water repellency causes at least temporal changes in the hydrological properties of a soil which result in, among other things, suboptimal growing conditions and increased irrigation requirements. Water repellency in soil is more widespread than previously thought and has been identified in many soil types under a wide array of climatic conditions worldwide. Consequences of soil water repellency include loss of wettability, increased runoff and preferential flow, reduced access to water for plants, reduced irrigation efficiency, increased requirement for water and other inputs, and increased potential for non-point source pollution. Research indicates that certain soil surfactants can be used to manage soil water repellency by modifying the flow dynamics of water and restoring soil wettability. This results in improved hydrological behavior of those soils. Consequently, the plant growth environment is also improved and significant water conservation is possible through more efficient functioning of the soil.
An FBAR Driven −261dB FOM Fractional-N PLL (2021)

A 1mW −261dB FOM PLL with 91fs jitter is presented that combines a low-noise, high-frequency FBAR reference with the unity-gain harmonic-mixing (HM) PLL to minimize reference noise gain and avoid entirely the amplification of sigma-delta modulator quantization noise and fractional spurs, which, in turn, allows for a substantially larger loop bandwidth to suppress the VCO noise and speed settling.
Use of a dual-pulse lithotripter to generate a localized and intensified cavitation field (2001)

Localizing cavitation to the kidney stone in extracorporeal shock wave lithotripsy may be desirable since cavitation appears to play a major role in both stone comminution and renal tissue damage. A method has been developed to localize and intensify cavitation damage in vitro. Cavitation fields in water were filmed with a high-speed digital video camera. In a conventional lithotripter (CL), the shock wave produced by a single source creates a 2 x 10 cm cylindrical cloud of bubbles in water. Bubbles in the CL field collapse simultaneously along the focal axis to produce a nearly uniform 1-mm x 8-cm line of pits in 25-microm-thick aluminum foil. Our dual-pulse lithotripter (DPL) uses two shock wave sources, facing each other, confocal, and triggered simultaneously to create a 4 x 5 cm cylindrical cloud of bubbles that collapse over a range of times and strengths such that the greatest pit damage on foils is contained within a few square millimeters of the focus. The time for bubbles to grow and collapse was measured with a focused hydrophone and compared with calculations based on the Gilmore equation. Pressure doubling due to synchronous arrival of the two pulses at the focus created increased bubble growth and increased foil pit depth. Asynchronous timing between the two pulses elsewhere in the DPL field resulted in disruption of radial dynamics and negligible pitting to foils. Translation of bubbles was also investigated, both numerically and experimentally. While net translation was calculated to be <0.3 mm in all cases, the rapid acceleration of bubbles in a small region may contribute to their premature destruction in that region. Overall, radial dynamics were found to be largely responsible for the observed pattern of cavitation in the dual-pulse lithotripsy field.