gebhart/patrepeval huggingface dataset:
A Scalable SiC Device for DC/DC Converters in Future Hybrid Electric Vehicles (2006)

The potential increased power density and high temperature capability of silicon carbide makes it an ideal candidate for use in future hybrid electric vehicle (HEV) technology. A secondary cooling system is required to maintain an 85degC base plate temperature for silicon based power electronics; but by creating a silicon carbide (SiC) based replacement this requirement could be relaxed. One anticipated benefit, among many, is that the secondary cooling loop could be eliminated and instead interfaced with the engine coolant system designed to maintain a maximum temperature of 105degC. The purpose of this paper is to present an all-SiC scaled prototype that is modeled after the DC-DC converter used in the Prius II to establish a high voltage DC bus interconnecting the motor and generator. The design uses a SiC JFET and SiC Schottky diode as the switching pair of a 1 kW scale model that investigates an inherently safe approach for use in future HEVs. The ability to parallel these unipolar devices results in a scalable device technology capable of achieving high-current, 600-V SiC switch technology in the near term that offers a potential 100degC increase in junction temperature above that rated for comparable silicon IGBTs
Spatial resolution in depth for time-resolved diffuse optical tomography using short source-detector separations (2014)

Diffuse optical tomography for medical applications can require probes with small dimensions involving short source-detector separations. Even though this configuration is seen at first as a constraint due to the challenge of depth sensitivity, we show here that it can potentially be an asset for spatial resolution in depth. By comparing two fiber optic probes on a test object, we first show with simulations that short source-detector separations improve the spatial resolution down to a limit depth. We then confirm these results in an experimental study with a state-of-the-art setup involving a fast-gated single-photon avalanche diode allowing maximum depth sensitivity. We conclude that short source-detector separations are an option to consider for the design of probes so as to improve image quality for diffuse optical tomography in reflectance.
Polarization-maintaining performance of large effective area, higher order modes fiber in a coiled configuration (2018)

Scaling the power-level of fiber sources has many practical advantages, while also enabling fundamental studies on the light-matter interaction in amorphous guiding media. In order to scale the power-level of fiber-sources without encountering nonlinear impairments, a strategy is to increase the effective-area of the guided optical-mode. Increasing the effective-area of the fundamental mode in a fiber, however, presents the challenges of increased susceptibility to mode-distortion and effective-area-reduction under the influence of bends. Therefore, higher-order-mode (HOM) fibers, which guide light in large effective-area (A<sub>eff</sub>) Bessel-like modes, are a good candidate for scaling the power-level of robust fiber-sources. Many applications of high-power fiber-sources also demand a deterministic control on the polarization-state of light. Furthermore, a polarization-maintaining (PM)-type HOM fiber can afford the added possibility of coherent-beam combination and polarization multiplexing of high-power fiber-lasers. Previously, we reported polarization-maintaining operation in a 1.3 m length of PM-HOM fiber that was held straight. The PM-HOM fiber guided Bessel-like modes with A<sub>eff</sub> ranging from 1200-2800 &mu;m<sup>2</sup>. In this work, we report, for the first time, that the polarization-extinction-ratio (PER) of the HOM exceeds 10 dB in an 8 m long fiber that is coiled down to a diameter of 40 cm. This opens a path towards compact and polarization-controlled high-power fiber-systems.
One Billion Word Benchmark for Measuring Progress in Statistical\n Language Modeling (2013)

We propose a new benchmark corpus to be used for measuring progress in\nstatistical language modeling. With almost one billion words of training data,\nwe hope this benchmark will be useful to quickly evaluate novel language\nmodeling techniques, and to compare their contribution when combined with other\nadvanced techniques. We show performance of several well-known types of\nlanguage models, with the best results achieved with a recurrent neural network\nbased language model. The baseline unpruned Kneser-Ney 5-gram model achieves\nperplexity 67.6; a combination of techniques leads to 35% reduction in\nperplexity, or 10% reduction in cross-entropy (bits), over that baseline.\n The benchmark is available as a code.google.com project; besides the scripts\nneeded to rebuild the training/held-out data, it also makes available\nlog-probability values for each word in each of ten held-out data sets, for\neach of the baseline n-gram models.\n
Reinduction with Certolizumab Pegol in Patients with Crohnʼs Disease Experiencing Disease Exacerbation (2016)

Certolizumab pegol was effective in many patients who previously discontinued certolizumab pegol for lack or loss of response. Thus, discontinuation of therapy may not always be necessary. Safety was consistent with previous findings.
Kerr-comb generation in a dispersion engineered coupled thin silicon nitride microresonators (2018)

We numerically demonstrate the first wideband Kerr-comb generation at telecommunication wavelength (1550 nm) using thin silicon nitride platform based on coupled-resonators structure for dispersion engineering.
STUDIES ON NORETHINDRONE COVALENTLY BONDED TO POLY-N**5(3-HYDROXYPROPYL)-L-GLUTAMINE. (1979)

This paper is concerned with the subject of sustained release of drugs from polymeric matrices. Until now only a few examples are available where steroids are covalently bonded to a polymeric system and no data are available about the coupling of steroids to biodegradable polymers. In this paper the authors report a new derivatization of 17 alpha -ethynyl-17 beta -hydroxy steroids which report applicable for attachment to biodegradable poly( alpha -amino acids). The reports covers the following topics - syntheses; in-vivo pharmacokinetic study; in-vitro lability study of carbonate bond between NE and the Spacer Group; in-vitro hydrolysis of compounds VI and VII; in vitro release of drug from compound VIII; immunologic and biocompatibility studies.
Direct synthesis with vanadium atoms. II. Synthesis and characterization of vanadium hexadinitrogen, V(N2)6, in low-temperature matrices (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDirect synthesis with vanadium atoms. II. Synthesis and characterization of vanadium hexadinitrogen, V(N2)6, in low-temperature matricesHelmut Huber, T. A. Ford, W. Klotzbuecher, and G. A. OzinCite this: J. Am. Chem. Soc. 1976, 98, 11, 3176–3178Publication Date (Print):May 1, 1976Publication History Published online1 May 2002Published inissue 1 May 1976https://pubs.acs.org/doi/10.1021/ja00427a019https://doi.org/10.1021/ja00427a019research-articleACS PublicationsRequest reuse permissionsArticle Views76Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
High-speed CMOS circuit testing by 50 ps time-resolved luminescence measurements (2001)

Noninvasive characterization of CMOS ring oscillators with 50 ps resolution is obtained by exploiting the broad-band infrared emission from switching transistors. A fast silicon single-photon avalanche-diode (SPAD) is used to attain high sensitivity and time resolution. Switching transitions of both nand p-channel MOSFETs are measured and the main features in the circuit operation are characterized. Systematic variations and increased jitter of switching transitions due to phase noise are accurately measured.
Immunolocalization of vault particles in cultured cells (1992)

We first reported on the existence of vault ribonucleoprotein particles in 1986, and since this study we have demonstrated that these unusual RNPs are ubiquitously expressed and highly conserved among diverse eukaryotes. These particles are quite large (65 x 35 nm) and distinctly regular in shape and dimensions. The polypeptide composition of vaults is also similar between species, dominated by a∼100 Kd protein which makes up &gt;70% of the particles mass. The RNA component of vaults, which has been sequenced and characterized from both rat and bullfrog, does not appear to serve a structural role, and due to the strong conservation of its secondary structure could serve a functional role.
ChemInform Abstract: TRANSITION METAL SUBSTITUTED VB ELEMENT SYSTEMS, IX. CONFORMATIONAL ISOMERISM OF COMPLEXES WITH ANTIMONY‐TRANSITION METAL BONDS (1976)

Abstract Durch Umsetzung von Dimethylantimonbromid bzw. Antimontribromid mit dem Fe‐Komplex (I) werden die Übergangsmetallkomplexe (II) und durch Weiterreaktion von (IIb) mit (I) das Derivat (III) dargestellt.
Image-derived arterial input function for quantitative fluorescence imaging of receptor-drug bindingin vivo (2015)

Receptor concentration imaging (RCI) with targeted-untargeted optical dye pairs has enabled in vivo immunohistochemistry analysis in preclinical subcutaneous tumors. Successful application of RCI to fluorescence guided resection (FGR), so that quantitative molecular imaging of tumor-specific receptors could be performed in situ, would have a high impact. However, assumptions of pharmacokinetics, permeability and retention, as well as the lack of a suitable reference region limit the potential for RCI in human neurosurgery. In this study, an arterial input graphic analysis (AIGA) method is presented which is enabled by independent component analysis (ICA). The percent difference in arterial concentration between the image-derived arterial input function (AIFICA ) and that obtained by an invasive method (ICACAR ) was 2.0 ± 2.7% during the first hour of circulation of a targeted-untargeted dye pair in mice. Estimates of distribution volume and receptor concentration in tumor bearing mice (n = 5) recovered using the AIGA technique did not differ significantly from values obtained using invasive AIF measurements (p = 0.12). The AIGA method, enabled by the subject-specific AIFICA , was also applied in a rat orthotopic model of U-251 glioblastoma to obtain the first reported receptor concentration and distribution volume maps during open craniotomy.
Microcavity white‐emitting OLED devices (2009)

Abstract— Microcavity designs for OLED devices with an unpatterned white emitter have the potential to provide greater brightness and larger color gamut than non‐microcavity designs while still enabling lower‐cost large‐format manufacturing. In this paper, such microcavity and non‐microcavity designs are compared. Color filters must still be employed to provide an adequate color gamut. Top‐emitter structures have somewhat greater on‐axis luminance and color gamut, but increased angular change, than bottom‐emitter designs. In a single‐stack bottom‐emitter active‐matrix TFT device using an RGBW format, the use of microcavities is estimated to reduce the average power usage by 35% and the peak power by 58%, while increasing the NTSC ratio for color gamut area by about 10%. Angular luminance and color change is likely to be acceptable, especially for hand‐held applications. Tandem devices employing multiple emitter stacks increase the lifetime of OLED devices but require larger driving voltages; for such devices, microcavity structures are useful although the percentage reduction obtained in power usage is not quite as large. Generally, tandem devices with microcavities have a slightly stronger cavity effect yielding slightly larger color gamut, but also greater angular color and luminance shift. Therefore, microcavity architectures are less appealing for tandem devices.
Challenges of porous SiCOH dielectric material integration for advanced interconnect technology nodes (2011)

International audience
Video-Correlated Real-Time Optical Coherence Tomography for Clinical Dermatology (2002)

An OCT system appropriate for evaluation in clinical dermatology is presented. Normal and a variety of diseased skin are imaged for demonstration. Correlated video enables accurate location of the OCT scan with respect to the skin surface.
Molecular Dynamics of Poly(ethylene glycol) and Poly(propylene glycol) Copolymer Networks by Broadband Dielectric Spectroscopy (2007)

The dynamic relaxation properties of amorphous rubbery networks prepared by the UV photopolymerization of poly(ethylene glycol) diacrylate [PEGDA] and poly(propylene glycol) diacrylate [PPGDA] cross-linkers have been investigated using broadband dielectric spectroscopy. Effective cross-link density in the networks was controlled by copolymerization of the diacrylate cross-linkers with monofunctional acrylates of similar chemical composition. For all of the networks examined, three motional transitions were detected with increasing temperature, including an intermediate “fast” relaxation located between the typical sub-glass and glass−rubber processes and corresponding to a subset of constrained segmental motions that were more local and less cooperative in nature as compared to those associated with the glass transition. The properties of the intermediate relaxation were sensitive to the degree of constraint imposed by the cross-link junctions: the dielectric intensity of the fast process decreased with decreasing effective cross-link density, and the characteristic relaxation broadening associated with this transition was less pronounced in networks containing a lower degree of cross-linking. The intermediate process detected in the cross-linked networks was comparable to a distinct sub-glass dispersion measured in crystalline poly(ethylene oxide) [PEO] and which has been attributed to constrained motions originating in the vicinity of the crystal−amorphous interface.
Structure–Activity Relationships of JMV4463, a Vectorized Cathepsin D Inhibitor with Antiproliferative Properties: The Unique Role of the AMPA‐Based Vector (2015)

Cathepsin D (CathD) is overexpressed and secreted by several solid tumors and stimulates their growth, the mechanism of which is still not understood. In this context, the pepstatin bioconjugate JMV4463 [Ac-arg-O2 Oc-(Val)3-Sta-Ala-Sta-(AMPA)4-NH2; O2 Oc=8-amino-3,6-dioxaoctanoyl, Sta=statine, AMPA=ortho-aminomethylphenylacetyl], containing a new kind of cell-penetrating vector, was previously shown to exhibit potent antiproliferative effects in vitro and to delay the onset of tumors in vivo. In this study, we performed a structure-activity relationship analysis to evaluate the significance of the inhibitor and vector moieties of JMV4463. By modifying both statine residues of pepstatin we found that the antiproliferative activity is correlated with CathD inhibition, supporting a major role of the catalytic activity of intracellular CathD in cancer cell proliferation. Replacing the vector composed of four AMPA units with other vectors was found to abolish cytotoxicity, although all of the conjugates enabled pepstatin transport into cells. In addition, the AMPA4 vector must be localized at the C terminus of the bioconjugate. The unexpected importance of the vector structure and position for cytotoxic action suggests that AMPA4 enables pepstatin to inhibit the proteolysis of critical CathD substrates involved in cell proliferation via a unique mechanism of action.
16.1 A 340mV-to-0.9V 20.2Tb/s source-synchronous hybrid packet/circuit-switched 16&#x00D7;16 network-on-chip in 22nm tri-gate CMOS (2014)

Energy-efficient networks-on-chip (NoCs) are key enablers for exa-scale computation by shifting power budget from communication toward computation. As core counts scale into the 100s, on-chip interconnect fabrics must support increasing heterogeneity and voltage/clock domains. Synchronous NoCs require either a single clock distributed globally or clock-crossing data FIFOs between clock domains [1]. A global clock requires costly full-chip margining and significant power and area for clock distribution, while synchronizing data FIFOs add power, performance, and area overhead per clock crossing. Source-synchronous NoCs mitigate these penalties by forwarding a local clock along with each packet, but still suffer from high data storage power due to packet switching. Circuit switching removes intra-route data storage, but suffers from low network utilization due to serialized channel setup and data transfer [2]. Hybrid packet/circuit switching parallelizes these operations for higher network utilization. A 16×16 mesh, 112b data, 256 voltage/clock domain NoC with source-synchronous operation, hybrid packet/circuit-switched flow control, and ultra-low-voltage optimizations is fabricated in 22nm tri-gate CMOS [3] to enable: i) 20.2Tb/s total throughput at 0.9V, 25°C, ii) a 2.7× increase in bisection bandwidth to 2.8Tb/s and 93% reduction in circuit-switched latency at 407ps/hop through source-synchronous operation, iii) a 62% latency improvement and 55% increase in energy efficiency to 7.0Tb/s/W through circuit switching, iv) a peak energy efficiency of 18.3Tb/s/W for near-threshold operation at 430mV, 25°C, and v) ultra-low-voltage operation down to 340mV with router power scaling to 363μW.
A Technology for Reducing Flicker Noise for ULSI Applications (2003)

It is demonstrated that the formation of the atomic scale flattened Si/SiO2 interface is effective in reducing the Flicker noise in n-channel metal oxide semiconductor field effect transistors (n-MOSFETs). The atomic scale flattened Si/SiO2 interface is realized, the atomic scale flattened silicon surface is obtained by the HF/HCl wet-etching process, and then the silicon surface is oxidized by radicals generated in Kr/O2 mixed high-density microwave-excited plasma at 400°C. Applying these techniques, the trap density at the Si/SiO2 interface is markedly reduced since the surface roughness is minimized and Flicker noise is markedly reduced as compared with the conventional process.
Inhibition of cyclin D1 expression in human pancreatic cancer cells is associated with increased chemosensitivity and decreased expression of multiple chemoresistance genes. (1999)

Cyclin D1 belongs to a family of protein kinases that have been implicated in cell cycle regulation. Inhibition of cyclin D1 expression has been recently shown (M. Kornmann, et al., J. Clin. Invest, 101: 344-352, 1998) to suppress pancreatic cancer cell growth and increase cytotoxic actions of cisplatinum. The aim of the present study was to determine whether inhibition of cyclin D1 expression also modulates the effects of other antineoplastic drugs and whether it is associated with alterations in the level of expression of drug resistance genes. The suppression of cyclin D1 expression after the stable transfection of a cyclin D1 antisense construct in PANC-1 and COLO-357 human pancreatic cancer cells resulted in a significant increase in sensitivity to the fluoropyrimidines 5-fluorouracil and 5-fluoro-2'-deoxyuridine and to mitoxantrone. All of the antisense-expressing dones exhibited a decrease in thymidylate synthase and an increase in thymidine phosphorylase mRNA expression as determined by reverse transcription-PCR analysis and decreased levels of MDR-1 and MRP mRNA as determined by Northern blotting. These findings demonstrate that the inhibition of cyclin D1, in addition to suppressing the growth of pancreatic cancer cells, enhances their responsiveness to multiple chemotherapeutic agents and suggest that this effect may be due to the altered expression of several chemoresistance genes.
Supplementary Table 3 from Molecular Profiling Establishes Genetic Features Predictive of the Efficacy of the p110β Inhibitor KIN-193 (2023)

&lt;p&gt;5 PTEN WT cell-lines from CCLE that are predicted to be resistant to KIN-193. Columns 1-6 give information on the prediction status of the cell-lines using MIA-RNMI and MIA-Eqwt models. Columns 7-9 give information on experimental validations based on published datasets.&lt;/p&gt;
Self-Rolling of Monolayer Graphene for Ultrasensitive Molecular Sensing (2021)

The controllable manipulation of graphene to create three-dimensional (3D) structures is an intriguing approach for favorably tuning its properties and creating new types of 3D devices. However, due to extremely low bending stiffnesses, it is rather challenging to construct monolayer graphene into stable 3D structures. Here, we demonstrate the stable formation of monolayer graphene microtubes with accompanying pre-patterned strain layers. The diameter of graphene microtubes can be effectively tuned by changing the thickness of the strain layers. Benefiting from a high surface-to-volume ratio of the tubular geometry, the 3D geometry leads to a prominent Raman enhancement, which was further applied to molecular sensing. The R6G molecules on graphene microtubes can be detected even for a concentration as low as 10<sup>-11</sup> M. We believe that this method can be a generalized way to realize the 3D tubular structure of other 2D materials.
SP-3 New frontiers in Urology (2004)

Locally, Grow GEobally" means reaching out tQ the world in clinical urology, discovery, and training.Remote and computer assisted surgery, int.ernational research and special training programs will be requirecl.Toward these goals a presentation will be made of the new biological concepts and molecular and computer technologies that are provicling new approaches to how we understand, prevent, and treat many urological diseases and how they can illteract globally.For the past one hundred and sixty years, (1840'L2000) there has been a linear in- crease in global life expectancy with a gain of a quarter of a year for every year.In this period there has been an increase of 40 years in life expectancy.As the population ages, the incidence of urological problems such as benign and malignant diseases rise rapidly in an almost exponential manner.Prevention will become important.In addition to aging, life styles change and populations adapt to Western types of diet, the risk of many cancers increases, It is now apparent