gebhart/patrepeval huggingface dataset:
Unidirectional movement of myosin-driven beads on immobilized F-actin arrays in a microfluidic channel (2009)

Actin-myosin system is a basic component to perform nanoscale biological transport in cells. Myosin walks along actin filament using chemical fuel, ATP, and the polarity of F-actin decides the direction of myosin movement. The present paper demonstrates unidirectional transport of microbeads along immobilized F-actin arrays in a microchannel. To transport myosin coated microbeads to the desired direction, polarity of F-actin is oriented using biotinylated actin-capping proteins and a flow field. Streptavidin coated microfluidic channel defines the direction of the flow field and biotinylated F-actin is oriented along the flow field. This technique will lay foundation for the future applications of autonomous transport and actuation systems, whether biological or synthetic in nature at nanoscale.
Metalloporphyrin DNA interactions: insights from NMR studies of oligodeoxyribonucleotides (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMetalloporphyrin DNA interactions: insights from NMR studies of oligodeoxyribonucleotidesJames A. Strickland, Luigi G. Marzilli, W. David Wilson, and Gerald ZonCite this: Inorg. Chem. 1989, 28, 23, 4191–4198Publication Date (Print):November 1, 1989Publication History Published online1 May 2002Published inissue 1 November 1989https://pubs.acs.org/doi/10.1021/ic00322a005https://doi.org/10.1021/ic00322a005research-articleACS PublicationsRequest reuse permissionsArticle Views66Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Relative Strength of Cation-π vs Salt-Bridge Interactions:  The Gtα(340−350) Peptide/Rhodopsin System (2006)

Interactions between cationic and aromatic side chains of amino acid residues, the so-called cation-pi interaction, are thought to contribute to the overall stability of the folded structure of peptides and proteins. The transferred NOE NMR structure of the G(t)alpha(340-350) peptide bound to photoactivated rhodopsin (R*) geometrically suggests a cation-pi interaction stabilizing the structure between the epsilon-amine of Lys341 and the aromatic ring of the C-terminal residue, Phe350. This interaction has been explored by varying substituents on the phenyl ring to alter the electron density of the aromatic ring of Phe350 and observing the impact on binding of the peptide to R*. The results suggest that while a cation-pi interaction geometrically exists in the G(t)alpha(340-350) peptide when bound to R*, its energetic contribution to the stability of the receptor-bound structure is relatively insignificant, as it was not observed experimentally. The presence of an adjacent and competing salt-bridge interaction between the epsilon-amine of Lys341 and the C-terminal carboxylate of Phe350 effectively shields the charge of the ammonium group. Experimental data supporting a significant cation-pi interaction can be regained through a series of Phe350 analogues where the C-terminal carboxyl has been converted to the neutral carboxamide, thus eliminating the shielding salt-bridge. TrNOE NMR experiments confirmed the existence of the cation-pi interaction in the carboxamide analogues. Various literature estimates of the strength of cation-pi interactions, including some that estimate strengths in excess of salt-bridges, are compromised by omission of the relevant anion in the calculations.
Differential role of tissue factor pathway inhibitors 1 and 2 in melanoma vasculogenic mimicry. (2003)

Vasculogenic mimicry (VM), the formation of matrix-rich vascular-like networks in three-dimensional culture corresponding with the expression of vascular cell-associated genes, and the lining of matrix-rich networks in situ, has been observed in highly aggressive and malignant melanoma. However, little is known about the molecular underpinnings of this phenomenon. On the basis of gene profiling, protein detection, and immunohistochemistry, aggressive relative to poorly aggressive melanoma showed up-regulation of tissue factor (TF), TF pathway inhibitor 1 (TFPI-1) and 2 (TFPI-2), critical genes that initiate and regulate the coagulation pathways. The procoagulant function of TF on highly aggressive melanoma is shown to be regulated by TFPI-1 but not by TFPI-2. Thus, aggressive melanoma exhibits endothelial cell-like anticoagulant mechanisms that may contribute to the fluid-conducting potential of melanoma cell-lined networks, as studied by correlative in vivo Doppler flow measurements. Antibody inhibition experiments reveal that TFPI-2 is required for VM in vitro, but plasmin is an unlikely target protease of TFPI-2. Blockade of TFPI-2 suppressed matrix metalloproteinase-2 activation, and, therefore, TFPI-2 appears to regulate an essential pathway of VM. TFPI-2 is synthesized by endothelial and tumor cells, which deposit TFPI-2 into extracellular matrices. Culturing poorly aggressive melanoma cells on three-dimensional matrix containing recombinant TFPI-2 produces some of the phenotypic changes associated with aggressive, vasculogenic melanoma cells. Thus, TFPI-2 contributes to VM plasticity, whereas TFPI-1 has anticoagulant functions of relevance for perfusion of VM channels formed by TF-expressing melanoma cells.
Toward Comprehensive Industrial Computed Tomography Image Quality Assessment: I. Phantom Design (2020)

Abstract When comparing the performance of different industrial X-ray computed tomography (CT) systems, reconstruction algorithms, or scan protocols, it is important to assess how well the required inspection and measurement tasks can be performed. Furthermore, it can be very informative to quantify image quality (IQ) metrics that can provide insight into the IQ characteristics that lead to the resulting inspection or measurement task performance. Inspection and measurement task performance is determined by basic characteristics such as spatial resolution; feature contrast, size, and shape; random noise (noise due to statistical uncertainty in measurements); and image artifacts. In this report, we describe a modular phantom set that enables robustly quantifying these characteristics and also enables assessing the performance of the inspection or measurement tasks themselves. The phantom set includes two phantom bodies and several insert types that can be optionally installed in the bodies. Phantom body extensions can be optionally included to increase scatter. The phantom bodies combined with the available insert types can comprehensively evaluate all important IQ metrics and inspection or measurement tasks. The precisely-known phantom body geometry and insert location, geometry, and orientation supports automatic analysis of large, complex experiments of multiple variables. This phantom set, with the associated image analysis software, could potentially serve as a general evaluation method for non-destructive testing (NDT) CT.
ChemInform Abstract: Terminal Olefin Cross‐Metathesis with Acrolein Acetals. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Measurement of the cross-section for electroweak production of dijets in association with a Z boson in pp collisions at s=13 TeV with the ATLAS detector (2017)

The cross-section for the production of two jets in association with a leptonically decaying Z boson (Z j j) is measured in proton-proton collisions at a centre-of-mass energy of 13 TeV, using data recorded with the ATLAS detector at the Large Hadron Collider, corresponding to an integrated luminosity of 3.2 fb -1 . The electroweak Z j j cross-section is extracted in a fiducial region chosen to enhance the electroweak contribution relative to the dominant Drell-Yan Z j j process, which is constrained using a data-driven approach. The measured fiducial electroweak cross-section is Zjj EW = 119 16 (stat.) 20 (syst.) 2 (lumi.) fb for dijet invariant mass greater than 250 GeV, and 34.2 5.8 (stat.) 5.5 (syst.) 0.7 (lumi.) fb for dijet invariant mass greater than 1 TeV. Standard Model predictions are in agreement with the measurements. The inclusive Z j j cross-section is also measured in six different fiducial regions with varying contributions from electroweak and Drell-Yan Z j j production.
Induction of Interleukin (IL)-8 Gene Expression by Respiratory Syncytial Virus Involves Activation of Nuclear Factor (NF)- B and NF-IL-6 (1996)

Respiratory syncytial virus (RSV) preferentially infects respiratory epithelium and is an important cause of lower respiratory tract infections in young children. RSV induces the production of interleukin (IL)-8 in airway epithelial cells; however, the mechanism of this induction is not known. To define the mechanism by which RSV induces IL-8 gene activation, A549 epithelial cells were transfected with plasmids containing serial deletions of the 5'-flanking region of the IL-8 gene and then exposed to RSV for 24 h. A positive cooperative effect of the binding sites for the transcription factors, nuclear factor (NF)-kappa B and NF-IL-6, was observed. Mutations in either region abates responsiveness of the promoter to RSV infection. RSV also increases activation of the NF-kappa B and NF-IL-6 transcription factors. These data suggest that RSV may increase IL-8 production in airway epithelium partly via activation of the transcription factors NF-kappa B and NF-IL-6.
Genetic control of immune response to myoglobin. Ir gene function in genetic restriction between T and B lymphocytes. (1982)

We studied the genetic restrictions on the interaction between T cells, B cells, and antigen-presenting cells (APC) involved in the H-2-linked Ir gene control of the in vitro secondary antibody response to sperm whale myoglobin (Mb) in mice. The B cells in this study were specific for Mb itself, rather than for a hapten unrelated to the Ir gene control, as in many previous studies. Low responder mice immunized in vivo with Mb bound to an immunogenic carrier, fowl gamma globulin (F gamma G), produced B cells competent to secrete anti-Mb antibodies in vitro if they received F gamma G-specific T cell help. However, (high-responder X low responder) F1 T cells from Mb-immune mice did not help these primed low responder (H-2k or H-2b) B cells in vitro, even in the presence of various numbers of F1 APC that were demonstrated to be component to reconstitute the response of spleen cells depleted by APC. Similar results were obtained with B6 leads to B6D2F1 radiation bone marrow chimeras. Genotypic low responder (H-2b) T cells from these mice helped Mb-primed B6D2F1B cells plus APC, but did not help syngeneic chimeric H-2b B cells, even in the presence of F1 APC. In contrast, we could not detect any Ir restriction on APC function during these in vitro secondary responses. Moreover, in the preceding paper, we found that low responder mice neonatally tolerized to higher responder H-2 had competent Mb-specific helper T cells capable of helping high responder but not low responder B cells and APC. Therefore, although function Mb-specific T cells and B cells both exist in low responder mice, the Ir gene defect is a manifestation of the failure of syngeneic collaboration between these two cell types. This genetic restriction on the interaction between T cells and B cells is consistent with the additional new finding that Lyb-5-negative B cells are a major participant in ths vitro secondary response because it is this Lyb-5-negative subpopulation of B cells that have recently been shown to require genetically restricted help. The Ir gene defect behaves operationally as a failure of low responder B cells to receive help from any source of Mb-specific T cells either high responder, low responder, or F1. The possible additional role of T cell-APC interactions, either during primary immunization in vivo or in the secondary culture is discussed.
Debio-025, a novel non-immunosuppressive cyclosporine analog with potent anti-human immunodeficiency virus type I activity: Pharmacological properties and mode of action (2005)

Reference LCBP-ARTICLE-2005-005View record in Web of Science Record created on 2006-02-09, modified on 2016-08-08
<title>Emission mechanism in molecularly doped light-emitting diodes</title> (1997)

The emission mechanisms of rubrene doped molecular organic light-emitting diodes (MOLEDs) is discussed in terms of energy transfer and direct carrier recombination at the dopant. The emission mechanism is investigate by using single layer devices composed of 5,6,11,12- tetraphenylnapthacene (rubrene) as the dopant and N,N'- diphenyl-N,N'-bis(3-methylphenyl)-1,1'-biphenyl- 4,4'-diamine (TPD) as the host. Efficient energy transfer form TPD to rubrene is suggested by current-voltage and drift mobility measurements of the doped and undoped TPD films in single layered devices. It is found that electrons can be injected into the hole transporter, TPD. The spatial distribution of the creation of rubrene excitons is studied by change in the thickness sand location of the doped TPD layer in multilayered devices. In rubrene doped TPD, the width of the emission zone extends about 20 nm form the Alq<SUB>3</SUB> interface. In undoped TPD, the diffusion length of TPD exciton is found to be no wider than 5 nm. The penetration depth of the electron injection into undoped TPD is found to be &lt;EQ 5 nm from the Alq<SUB>3</SUB> interface. By rubrene doping, the penetration depth of electron injection seems to be extended beyond 5 nm. The dominant emission mechanism for rubrene-doped TPD is attributed to the electron-hole recombination on rubrene molecules.
The Digital Audio Processing Station: A New Concept in Audio Postproduction (1986)

Architecture de la station de traitement de l'enregistrement du son. Operations de studio basees sur le processeur de signal dans le domaine des audiofrequences
CD36 Is Not Involved in Scavenger Receptor–Mediated Endocytic Uptake of Glycolaldehyde- and Methylglyoxal-Modified Proteins by Liver Endothelial Cells (2005)

Circulating proteins modified by advanced glycation end-products (AGE) are mainly taken up by liver endothelial cells (LECs) via scavenger receptor-mediated endocytosis. Endocytic uptake of chemically modified proteins by macrophages and macrophage-derived cells is mediated by class A scavenger receptor (SR-A) and CD36. In a previous study using SR-A knockout mice, we demonstrated that SR-A is not involved in endocytic uptake of AGE proteins by LECs [Matsumoto et al. (2000) Biochem. J. 352, 233-240]. The present study was conducted to determine the contribution of CD36 to this process. Glycolaldehyde-modified BSA (GA-BSA) and methylglyoxal-modified BSA (MG-BSA) were used as AGE proteins. 125I-GA-BSA and 125I-MG-BSA underwent endocytic degradation by these cells at 37 degrees C, and this process was inhibited by several ligands for the scavenger receptors. However, this endocytic uptake of 125I-GA-BSA by LECs was not inhibited by a neutralizing anti-CD36 antibody. Similarly, hepatic uptake of (111)In-GA-BSA after its intravenous injection was not significantly attenuated by co-administration of the anti-CD36 antibody. These results clarify that CD36 does not play a significant role in elimination of GA-BSA and MG-BSA from the circulation, suggesting that the receptor involved in endocytic uptake of circulating AGE proteins by LEC is not SR-A or CD36.
Methods of preparing flexible photovoltaic devices using epitaxial liftoff, and preserving the integrity of growth substrates used in epitaxial growth (2023)

There is disclosed methods of making photosensitive devices, such as flexible photovoltaic (PV) devices, through the use of epitaxial liftoff. Also described herein are methods of preparing flexible PV devices comprising a structure having a growth substrate, wherein the selective etching of protective layers yields a smooth growth substrate that us suitable for reuse.
Extremely low-amplitude modulation in a subharmonically hybrid mode-locked monolithic semiconductor laser (1996)

Negligibly small amplitude modulation and sufficiently low timing jitter are achieved simultaneously in a passively mode-locked monolithic semiconductor laser stabilized by applying an electrical signal at the second subharmonic of the pulse repetition frequency. Nearly transform-limited 33 GHz pulse trains with 0.56 ps timing jitter and -23 dBc amplitude modulation are obtained with 23 dBm driving signals at 16.5 GHz. Detailed investigations are carried out on the dependence of the amplitude modulation and timing jitter on RF driving power for the second- and third-order subharmonic cases. The excellent amplitude modulation property of the second subharmonic case with the specific laser used in this work is ascribed to the frequency response characteristics of the device.
Antigen-Microarray Profiling of Antibodies in SLE: A Personal View ofTranslation from Basic Science to the Clinic (2016)

In October of 2015, the startup company ImmunArray announced the launch of a microarray platform – the iChip® – to profile repertoires of serum antibodies and autoantibodies. The first iChip® product – the SLE-key® RuleOut test – is designed to help the physician rule out a diagnosis of systemic lupus erythematosus (SLE) in suspected patients. The aim of this review is threefold: the first aim is to describe how basic observations and a philosophical notion led me to undertake the development of what has turned out to be a clinically useful aid in dealing with complex diseases; the second aim is to describe the role of a company in overcoming the technological and informatics challenges involved in translating basic research into patient welfare; the third aim is to discuss why SLE, like other complex medical problems, can be better managed using immune profiling. Basic scientist readers might learn here about the path to clinical application; clinician readers might learn here about the complicated origins of seemingly simple tests.
5G multi-RAT multi-connectivity architecture (2016)

The 5th generation of mobile networks is envisioned to unify different access types under one system in order to enable efficient and performant operations. We propose a radio network architecture for tight integration of multiple radio access technologies supporting traffic steering, link selection, and aggregation of traffic flows from and to different sources. This enables the radio network architecture to support better throughput, and increased reliability with different levels of mobility. Specifically, we propose a common user plane and control plane across different radio technologies utilizing similar principles, such that the joint operation of radio technologies can be optimized.
A fully packaged multi-channel cryogenic module for optical quantum memories (2023)

Realizing a quantum network will require long-lived quantum memories with optical interfaces incorporated into a scalable architecture. Color centers quantum emitters in diamond have emerged as a promising memory modality due to their optical properties and compatibility with scalable integration. However, developing a scalable color center emitter module requires significant advances in the areas of heterogeneous integration and cryogenically compatible packaging. Here we report on a cryogenically stable and network compatible quantum-emitter module for memory use. This quantum-emitter module is a significant development towards advanced quantum networking applications such as distributed sensing and processing.
Porosity, underfill and magnesium loss during continuous wave Nd:YAG laser welding of thin plates of aluminum alloys 5182 and 5754 (1999)

The influence of various welding parameters on porosity and underfill formation and magnesium loss during continuous wave Nd:YAG laser beam welding of thin plates of aluminum-magnesium Alloys 5182 and 5754 was investigated. The porosity within the welds was characterized by radiography, optical microscopy and SEM. The compositional change in the welds was measured by electron microprobe analysis. The experimental results showed that the instability of the keyhole was the dominant cause of macro-porosity formation during laser welding of thin plates of aluminum Alloys 5182 and 5754. Hydrogen did not play a significant role in porosity formation. Although underfill was commonly observed at the root of full-penetration welds, sharp or deep notches, which are harmful to the mechanical properties of the welds, were not present. Reduction in magnesium concentration was more pronounced during conduction mode welding. Welding in keyhole mode resulted in much larger weld pool and less pronounced composition change. The extent of defocusing of the laser beam greatly affected the stability of the keyhole, weld pool geometry, pore formation and composition change.
Ten-year all-cause death after percutaneous or surgical revascularization in diabetic patients with complex coronary artery disease (2021)

SYNTAX: ClinicalTrials.gov reference: NCT00114972 and SYNTAX Extended Survival: ClinicalTrials.gov reference: NCT03417050.
Effective strategies for translating basic research into clinical success in Alzheimer's disease (2014)

David Cameron held a summit of G8 ministers in December 2013 to shape an international response to the global dementia challenge. WHO director general Margaret Chan declared: “In terms of a cure, or even a treatment that can modify the disease, we are empty handed.” The health ministers’ response was: “The ambition to identify a cure or a disease-modifying therapy for …
Preparation of Glucose Sensor Using Polydimethylsiloxane / Polypyrrole Complex (2003)

New glucose oxidase (GOD) immobilized glucose sensors were prepared by the electropolymerization of 1-(6-D-gluconamidohexyl) pyrrole (GHP) on the platinum wire electrode precoated with the mixture solution of pyrrole derivative GHP, polydimethylsiloxane (PDS) and Nafion. The addition of Nafion into the precoating mixture solution was essential to obtain suitable sensor sensitivity. However, the sensitivity was about the half of that of the electrode without PDS precoating. Although, the introduction of Nafion was effective to improve the long-term stability of the enzyme-immobilized electrode, the electrode prepared using Nafion, PDS and GHP performed excellent long-term stability even at the measurement and storage temperatures of 40°C. Relatively constant response current was obtained over 30 days under the condition of 40°C and over 9 months measured at 25°C. Moreover, the GOD-immobilized GHP polymer film prepared on the electrode precoated with GHP, PDS and Nafion solution, was found to have excellent hemocompatibility from the result of platelet rich plasma contacting test.