gebhart/patrepeval huggingface dataset:
Search for the suppressed decays B+→K+K+π− and B+→π+π+K− (2016)

A search is made for the highly-suppressed B meson decays B + K + K + -and B + + + K -using a data sample corresponding to an integrated luminosity of 3.0 fb -1 collected by the LHCb experiment in proton-proton collisions at centre-of-mass energies of 7 and 8 TeV. No evidence is found for the decays, and upper limits at 90% confidence level are determined to be B(B + K + K + -) < 1.1 10 -8 and B(B + + + K -) < 4.6 10 -8 .
Thrombotic thrombocytopenic purpura in systemic lupus erythematosus: disease activity and the use of cytotoxic drugs (2002)

Thrombotic thrombocytopenic purpura (TTP) is a rare and occasionally fatal haematologic disorder that can coexist with systemic lupus erythematosus (SLE) and other autoimmune diseases. We identified all cases of TTP seen in our institution over a 3 year period using a computerized database. We found that SLE activity (measured by the SLE Disease Activity Index) and TTP activity ran a parallel course in three patients with coexistent SLE and TTP. TTP in these three patients, although refractory to plasmapheresis, responded to cytotoxic therapy. These observations further support an autoimmune contribution to the pathogenesis of some cases of TTP. A literature review revealed that mortality in SLE patients with more severe, refractory TTP treated with plasmapheresis and cytotoxics, may not be higher than in patients responding to plasmapheresis alone (who are likely to have milder disease). These data suggest that cytotoxics may have a role in treatment of patients with active SLE and TTP refractory to plasmapheresis.
Investigations of GaP for terahertz wave generation using quasi-phasematched difference frequency mixing (2002)

Undoped high-resistivity GaP crystal is being investigated as a nonlinear element in a difference frequency generation (DFG) scheme to generate a tunable, narrow-band, FIR idler wave using near-infrared (NIR) pump and signal sources.
Real-Time Visualization of CO2 Generated by Corrosion of the Carbon Support in a PEFC Cathode (2012)

Start-up and shut-down cycling in PECFs causes severe degradation, because the carbon supports at the cathode catalyst layers are corroded due to the instantaneous reaction with H2O. We developed a new CO2 visualization system using a CO2-sensitive dye for detecting the generation of CO2 during the corrosion processes in real time and with spatial resolution. The corrosion occurring during the shut-down process continued longer near the inlet and produced a more serious effect than during the start-up process, near the outlet. This new CO2 visualization technique should help to minimize the corrosion of carbon supports in all types of PEFCs.
Lysozyme Secretion by Submucosal Glands Protects the Airway from Bacterial Infection (2005)

Submucosal glands are abundant (approximately 1 gland/mm2) secretory structures in the tracheobronchial airways of the human lung. Because submucosal glands express antibacterial proteins, it has been proposed that they contribute to lung defense. However, this concept is challenged by the fact that mice do not have submucosal glands in their bronchial airways, yet are quite resistant to bacterial lung infection. The contribution of airway submucosal glands to host defense is also debated as a pathophysiologic component of cystic fibrosis lung disease. Here, we asked whether submucosal glands protect airways against bacterial infection. By comparing tracheal xenograft airways with and without glands, we found that the presence of glands enhanced bacterial killing in vivo and by airway secretions in vitro. Moreover, immunodepletion studies suggested that lysozyme is a major antibacterial component secreted by submucosal glands. These studies provide evidence that submucosal glands are a major source of antibacterials critical for maintaining sterile airways.
Energy-efficient information collection and dissemination in wireless sensor networks (2009)

Low-power sensors, equipped with limited capability of sensing, computation, and communication, and limited battery power, can form an ad hoc network, providing versatile scopes into both the physical world and human spaces. 
For information collection and dissemination in wireless sensor networks (WSNs), a key challenge is the limited energy in each sensor node. Although the sensor hardware platforms have been designed with low-power components, achieving high application performance while minimizing energy consumption is very challenging. 
To meet this challenge, this thesis proposes energy-efficient protocols and systems for WSNs. First, we develop an opportunistic in-network data aggregation scheme for WSNs, which can compensate for communication losses without incurring computation error, and achieve better energy efficiency than other approaches that rely on retransmission. 
Next, we propose a data-centric approach for post-deployment performance debugging in WSNs. It focuses on the data flows a WSN application generates, and relates poor application performance to significant data losses or latencies of some data flows (i.e., problematic flows) as they go through the software modules on individual nodes and through the network. It collects debugging information from only those modules and nodes that the problematic flows go through, and therefore consumes much less energy than collecting debugging information indiscriminately from all nodes. 
WSNs sometimes contain mobile data sinks. Maintaining high packet delivery ratio becomes more difficult as the network gets bigger and mobile moves faster. Thus, we design a distributed location service protocol which can sustain a high packet-delivery ratio in larger networks and at higher mobile speeds, and incur lower energy consumption than other location service protocols. We also determine how to configure the protocol parameters to ensure the scalability of the location service. 
Last, we explore the tradeoff between location privacy protection and energy consumption in people-centric sensing applications. The key idea of our approach is to prevent the distinguishability of a mobile user's points of interest (POIs), therefore weakening attackers' ability to infer the user's private information or mobility patterns. Our evaluation using real-world traces shows that it protects mobile users' location privacy effectively and consumes battery of their handhelds efficiently.
P‐17.2: Automotive multi‐screen with ambient light sensor (2021)

BOE has made a 12.3‐inch automotive multi‐screen module with ambient light sensor. This product integrates the ambient light sensor on the surface of the panel, and the demo can realize 4K high resolution display and can support separate display by screen. At the same time, in order to make the product more beautiful and simple, the ultra narrow splicing design is used.
Third-harmonic injection technique applied to a 5.87-to-7.56GHz 65nm CMOS Class-F oscillator with 192dBc/Hz FOM (2013)

The design of CMOS oscillators for the strict phase noise (PN) requirements of cellular standards, as well as low power consumption and thus high figure-of-merit (FoM), is very challenging. For example, in a GSM mobile station (MS), the PN requirement is -162dBc/Hz at 20MHz offset from a 915MHz carrier for a local oscillator (LO). On the other hand, LO power efficiency is a critical factor for a long-lasting battery life.
Stability of 20S Proteasome Configurations: Preopening the Axial Gate (2023)

Mass spectrometry studies of the stability of the <i>S. cerevisiae</i> 20S proteasome from 11 to 55 °C reveal a series of related configurations and coupled transitions that appear to be associated with opening of the proteolytic core. We find no evidence for dissociation, and all transitions are reversible. A thermodynamic analysis indicates that configurations fall into three general types of structures: enthalpically stabilized, tightly closed (observed as the +54 to +58 charge states) configurations; high-entropy (+60 to +66) states that are proposed as precursors to pore opening; and larger (+70 to +79) partially and fully open pore structures. In the absence of the 19S regulatory unit, the mechanism for opening the 20S pore appears to involve a charge-priming process that loosens the closed-pore configuration. Only a small fraction (≤2%) of these 20S precursor configurations appear to open and thus expose the catalytic cavity.
Carbin-Iridium-Komplexe: Nachweis eines Gleichgewichts zwischen Alkenyliden(hydrido)- und Carbin-Isomeren (1986)

Nicht das ß-C-Atom, sondern das Metallzentrum wird bei der Umwandlung des quadratisch-planaren Alkenyliden-Komplexes 1 in den Carbin-Komplex 3 primär protoniert. Im Festkörper liegt laut IR-Spektrum das Gleichgewicht mehr auf der Seite des Hydrido-Komplexes 2. die Reaktion 1→3 ist reversibel: Mit NaH läßt sich 1 wieder freisetzen.
A stochastic particle-based biological system simulator (2007)

The simulation and visualization of biological systems is expected to enhance our understanding of biological processes towards the development of effective therapeutic treatments. Biological systems are inherently stochastic at the molecular level, exhibit modified behavior under crowded conditions and may be affected by spatial locality. Common simulation approaches fail to account for these important aspects of biological systems, in part because they are computationally expensive. Here, we describe a stochastic, particle-based simulator that takes spatial locality into account. Each particle in the system is represented explicitly on a 3D grid where only one particle can occupy a grid location. The grid structure and stochastic approach removes the need for distance calculation and particle search. We demonstrate the effect of molecular crowding and spatial locality for a simple biological system. We anticipate that this system will be useful in examining more complex systems. Finally, this system is expected to be suitable for acceleration with parallel customizable hardware, a necessary requirement towards the simulation of an entire cell.
Transition Metal—Catalyzed Cross Coupling Reactions (1998)

Transition metal-catalyzed cross-coupling reactions have proved to be powerful tools for carbon–carbon as well as carbon–heteroatom bond formation in the development of synthetic methodologies for applications ranging from pharmaceuticals to materials. This book, consisting of an editorial, two reviews and two articles, focuses on recent promising research and novel trends in the field of cross-coupling reactions, employing a range of different catalysts. A review by Kostas and Steele provides a survey of the research in the area of cross-coupling catalytic reactions with transition metal complexes based on the thiosemicarbazone unit and a discussion of the prospects for future developments. Another review by Polychronopoulou, Shaya and co-authors describes the progress made over the 21st century concerning the utilization of C(sp3)–organoboranes as partners in metal-catalyzed C(sp3)–C(sp2) cross-couplings, such as B-alkyl Suzuki–Miyaura reactions. The article by Waldvogel, Breinbauer and co-authors demonstrates for the first time the synthetic potential of combining the electro-oxidative dehydrogenative cross coupling of ortho-substituted phenols with Pd-catalyzed cross-coupling reactions. In the second article, Štĕpnička and co-workers describe the preparation of palladium catalysts deposited over silica gel-bearing composite amide-donor functional moieties on the surface, which were evaluated in the Sonogashira-type cross-coupling of acyl chlorides with terminal alkynes.
Clonidine added to bupivacaine enhances and prolongs analgesia after brachial plexus block via a local mechanism in healthy volunteers (2004)

The admixture of clonidine to bupivacaine plus epinephrine prolongs and enhances brachial plexus blockade. Lower clonidine plasma concentrations for block treatment strongly suggest a local effect.
Condensation of Lactones with Primary Diamines (2021)

The condensation of dehydroacetic acid and 4-hydroxy-6-methylpyran-2-one with primary diamine derivatives such as hydrazine, 1,2-diaminoethane and 1,6-diaminohexane yielded bispyrone and bispyridone derivatives has been reported. The condensation of 4-hydroxy-6-methylpyran-2-one with hydrazine in acetonitrile generated another bispyrazole product but in n-butanol, this reaction afforded the bispyridones. The structures of the synthesized bispyrazoles were examined by spectroscopy and X-ray diffraction analysis, while those of bispyridones were established by spectroscopy data (NMR, mass). Some new complexes were also synthesized in order to show the behaviour of ligands with suitable crystals for X-ray analysis.
Fluorescence lifetime imaging microscopy (2000)

We demonstrate the application of a time-domain 2D fluorescence lifetime imaging (FLIM) system to microscopy of biological tissue. We report the extension of this work to 3D FLIM microscopy.
Supplementary Figure S4 from A Novel Sulforaphane-Regulated Gene Network in Suppression of Breast Cancer–Induced Osteolytic Bone Resorption (2023)

&lt;p&gt;Runt-related transcription factor 2 (RUNX2) occupancy at the promoter of matrix metallopeptidase 9 (MMP9).&lt;/p&gt;
Computation of Aerodynamic Noise Emitted From a Door Mirror of a Passenger Car and its Synthesis (1996)

Abstract The aerodynamic noise caused by an outside door mirror of a passenger car was calculated and synthesized. Flows around the car including the mirror were computed using a finite-difference method and an overlapping grid technique. Sound pressure of the aerodynamic noise in far field from the car was computed with Curie’s formula using unsteady pressure distribution on the mirror which is numerically solved from the incompressible Navier-Stokes equations. The sound is then synthesized for engineers to evaluate. We investigate the relation between noise sources and the flow field, and find that the strong noise sources are distributed along sepalation lines. This means it possible to reduce the noise if we can avoid separation or fix sepalation lines. Considering it, we modified the mirror shape and succeeded to reduce the aerodynamic noise.
Study of Target Value Determination Method for Feedback Control during Shifting in an Automatic Transmission. (2000)

Target value determination method for feedback control during gear shifting has been investigated in order to improve drivability for a vehicle with an automatic transmission. Feature of the method is to equalize target value with estimated driven shaft torque until starting time of feedback control and to set up target value from torque changing point which occurs at the beginning of inertia phase. Therefore, deviation of the estimated torque and target value when starting time of feedback control becomes almost zero and smoth gear shift by feedback control can be realized. Moreover, smooth gear shift control method based on the estimated torque during accelerator pedal operating has been proposed and the effectiveness of the proposed control method has been verified.
Molecular dynamics simulations of nanoparticle growth… and beyond (2020)

Invited seminar : PLASMANT group and Nanolab Center of Excellence, University of ANvers, given 28 February 2020
Measurement of Thin Oxide Films on Implanted Si-Substrate by Ellipsometry (1994)

In this study, the thickness of oxide film which is deposited by low-temperature chemical vapor deposition (LTCVD) on an implanted silicon substrate was measured by multiple-angle incident (MAI) ellipsometry. By using this method, the refractive index, thickness, and the effective index of the substrate can be calculated simultaneously. It is found that the thickness of oxide film on an implanted silicon substrate is only 4% different from that on a nonimplanted silicon substrate under the same deposition conditions. The result shows that a higher implantation energy results in a higher effective substrate index. Even with a high temperature and long annealing process, the refractive index of the implanted silicon substrate cannot recover to the value of nonimplanted silicon substrate.
Supplementary Methods from Expression Profiling in Progressive Stages of Fumarate-Hydratase Deficiency: The Contribution of Metabolic Changes to Tumorigenesis (2023)

Supplementary Methods from Expression Profiling in Progressive Stages of Fumarate-Hydratase Deficiency: The Contribution of Metabolic Changes to Tumorigenesis
Kallikrein-induced uterine contraction independent of kinin formation. (1981)

Responses of smooth muscle to kallikreins (EC 3.4.21.8) are generally considered to result from kinin formation. This premise was reexamined with the isolated rat uterus. Rat urinary kallikrein or bradykinin produced dose-dependent contractions of rat uterus but kallikrein was 5-fold more potent than bradykinin. Kallikrein caused an immediate series of rhythmic contractions which could be increased gradually with subsequent addition of kininogen substrate. Kallikrein-induced contractions were unaffected by carboxypeptidase B or a bradykinin antiserum whereas bradykinin-induced contractions were attenuated or abolished. Other serine proteinases, including trypsin, either did not induce contraction in the absence of added kininogen or did so minimally. Although small amounts of kininogen-like substrate were found in uterine tissue, detectable kinin levels (greater than 4 pg) could not be found in bathing media during maximal kallikrein-induced contractions or after uterine tissue was incubated with high concentrations of the enzyme in the presence of SQ 20881, a kininase II inhibitor. The data suggest that uterine contraction produced by a homologous kallikrein does not involve kinin formation but results from an action of this serine proteinase upon other accessible systems coupled to the contractile response.
Second-order radiometric ray tracing (1996)

Conventional ray-tracing methods fail for non-Lambertian sources. To address this deficiency, we introduce a radiometric ray-tracing (R2T) method, applicable to quasi-homogeneous sources of arbitrary spatial coherence. Based on Fourier optics, applied to physical radiometry in the radiance transfer function second-order approximation, the R2T method retains the standard ray-tracing codes but modifies them to include phase-space weighting factors attached to conventional geometric rays.
Development of an Immunoaffinity Process for Factor IX Purification (1990)

An immunoaffinity process based on monoclonal antibody (MAb) to factor IX (FIX) has been developed. Initially, vitamin-K-dependent proteins from cryoprecipitate-poor plasma are isolated on DEAE-Sephadex. The eluate is applied to an immunoaffinity column that utilizes a divalent metal-ion-dependent MAb directed against FIX. After washing the column with high salt in the presence of magnesium ion, the FIX is eluted using a citrate- or EDTA-containing buffer. Coagulation assays and Western blots show no detectable amounts of any contaminating proteins. Purity of the FIX product is established using reduced and nonreduced Coomassie-stained SDS-PAGE and HPLC. The N-terminal 20 amino acids of the single peak of the HPLC were shown to be identical to those reported for FIX. The process shows no detectable leakage of monoclonal antibodies (MAb), efficient utilization of MAb, and provides yields greater than 95%. The use of solvent/detergent treatment as a potential viral inactivation methods is incorporated in the process. Studies with tritiated Triton X-100 indicate that the detergent can be washed out of the MAb column so that less than 1 ppm (total) Triton X-100 coelutes with the FIX.
Data from Medium-throughput Drug Screening of Patient-derived Organoids from Colorectal Peritoneal Metastases to Direct Personalized Therapy (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;Patients with colorectal cancer with peritoneal metastases (CRPMs) have limited treatment options and the lowest colorectal cancer survival rates. We aimed to determine whether organoid testing could help guide precision treatment for patients with CRPMs, as the clinical utility of prospective, functional drug screening including nonstandard agents is unknown.&lt;/p&gt;Experimental Design:&lt;p&gt;CRPM organoids (peritonoids) isolated from patients underwent parallel next-generation sequencing and medium-throughput drug panel testing &lt;i&gt;ex vivo&lt;/i&gt; to identify specific drug sensitivities for each patient. We measured the utility of such a service including: success of peritonoid generation, time to cultivate peritonoids, reproducibility of the medium-throughput drug testing, and documented changes to clinical therapy as a result of the testing.&lt;/p&gt;Results:&lt;p&gt;Peritonoids were successfully generated and validated from 68% (19/28) of patients undergoing standard care. Genomic and drug profiling was completed within 8 weeks and a formal report ranking drug sensitivities was provided to the medical oncology team upon failure of standard care treatment. This resulted in a treatment change for two patients, one of whom had a partial response despite previously progressing on multiple rounds of standard care chemotherapy. The barrier to implementing this technology in Australia is the need for drug access and funding for off-label indications.&lt;/p&gt;Conclusions:&lt;p&gt;Our approach is feasible, reproducible, and can guide novel therapeutic choices in this poor prognosis cohort, where new treatment options are urgently needed. This platform is relevant to many solid organ malignancies.&lt;/p&gt;&lt;/div&gt;
Numerical and experimental investigations of tip clearance effects in a high-flow-coefficient centrifugal compressor (2022)

Abstract This paper focuses on the investigation of the blade deformation and tip clearance effects of a high-flow-coefficient centrifugal compressor. Blade deformation caused by the pressure load and centrifugal load under operating condition is considered by fluid/solid interaction method to simulate the stage performance accurately. Hence the numerical results are in good agreement with the experimental data. The blade deformation is then analyzed in detail. Also, the effect of the size of tip clearance is studied by evaluating the performance with five various gaps. The result shows that the increment of the tip clearance from 0 to 2.0 mm leads to a 5.14% peak efficiency decline. However, increasing tip gap contributes to enlarge the stable operating range in terms of stall margin and choke margin.