gebhart/patrepeval huggingface dataset:
Biomarkers of cavernous angioma with symptomatic hemorrhage (2019)

BACKGROUNDCerebral cavernous angiomas (CAs) with a symptomatic hemorrhage (CASH) have a high risk of recurrent hemorrhage and serious morbidity.METHODSEighteen plasma molecules with mechanistic roles in CA pathobiology were investigated in 114 patients and 12 healthy subjects. The diagnostic biomarker of a CASH in the prior year was derived as that minimizing the Akaike information criterion and validated using machine learning, and was compared with the prognostic CASH biomarker predicting bleeding in the subsequent year. Biomarkers were longitudinally followed in a subset of cases. The biomarkers were queried in the lesional neurovascular unit (NVU) transcriptome and in plasma miRNAs from CASH and non-CASH patients.RESULTSThe diagnostic CASH biomarker included a weighted combination of soluble CD14 (sCD14), VEGF, C-reactive protein (CRP), and IL-10 distinguishing CASH patients with 76% sensitivity and 80% specificity (P = 0.0003). The prognostic CASH biomarker (sCD14, VEGF, IL-1β, and sROBO-4) was confirmed to predict a bleed in the subsequent year with 83% sensitivity and 93% specificity (P = 0.001). Genes associated with diagnostic and prognostic CASH biomarkers were differentially expressed in CASH lesional NVUs. Thirteen plasma miRNAs were differentially expressed between CASH and non-CASH patients.CONCLUSIONShared and unique biomarkers of recent symptomatic hemorrhage and of future bleeding in CA are mechanistically linked to lesional transcriptome and miRNA. The biomarkers may be applied for risk stratification in clinical trials and developed as a tool in clinical practice.FUNDINGNIH, William and Judith Davis Fund in Neurovascular Surgery Research, Be Brave for Life Foundation, Safadi Translational Fellowship, Pritzker School of Medicine, and Sigrid Jusélius Foundation.
Predicting postpartum changes in emotion and behavior via social media (2013)

We consider social media as a promising tool for public health, focusing on the use of Twitter posts to build predictive models about the forthcoming influence of childbirth on the behavior and mood of new mothers. Using Twitter posts, we quantify postpartum changes in 376 mothers along dimensions of social engagement, emotion, social network, and linguistic style. We then construct statistical models from a training set of observations of these measures before and after the reported childbirth, to forecast significant postpartum changes in mothers. The predictive models can classify mothers who will change significantly following childbirth with an accuracy of 71%, using observations about their prenatal behavior, and as accurately as 80-83% when additionally leveraging the initial 2-3 weeks of postnatal data. The study is motivated by the opportunity to use social media to identify mothers at risk of postpartum depression, an underreported health concern among large populations, and to inform the design of low-cost, privacy-sensitive early-warning systems and intervention programs aimed at promoting wellness postpartum.
ChemInform Abstract: β‐Phosphorylated α‐Phenyl‐N‐tert‐butylnitrone (PBN) Analogues: A New Series of Spin Traps for Oxyl Radicals. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Minimum deviation digital controller IC for single and two phase dc-dc switch-mode power supplies (2010)

A digital PWM voltage mode controller integrated circuit (IC) for high-frequency dc-dc switching converters achieving virtually minimum possible, i.e. optimum, output voltage deviation to load transients is introduced. The IC is implemented with simple hardware, requiring small silicon area, and can operate as a single-phase or a two-phase controller. To minimize the area and eliminate known mode transition problems of the optimal response controllers, two novel blocks are combined. Namely, an asynchronous track-and-hold analog-to-digital converter (ADC) and a “large-small” signal compensator are implemented. The ADC utilizes a pre-amplifier and only four comparators having approximately eight times smaller silicon area and power consumption than an equivalent windowed flash architecture. The “large-small” signal compensator consists of two parts, a digital PID minimizing small variations and a zero-current detection-based compensator suppressing large load transients. The large-signal compensator requires no extra calculations and has a low sensitivity to parameter variations. It utilizes a synchronization algorithm and the PID calculation results to obtain a bumpless mode transition and stable response to successive load transients. The IC occupying only 0.26 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> silicon area is implemented in a CMOS 0.18µm process and its minimum deviation response is verified with a single and dual-phase 12 V-to−1.8 V, 500 kHz 60/120 W buck converter.
High Bandwidth Active Gate Driver for Simultaneous Reduction of Switching Surge and Switching Loss of SiC-MOSFET (2022)

This paper investigates an active gate driver (AGD) for an SiC-MOSFET. The source current feedback type active gate driver utilizes the reactive voltage of the source wire inductance as a negative feedback signal to regulate the source current di/dt. Recently, the improvement of the switching performance of the AGD is limited due to the feedback system bandwidth. In this paper, a high bandwidth current feedback type power operational amplifier is applied as the gate drive circuit. Switching characteristics of the conventional resistive gate driver and the active gate driver are experimentally investigated by a double pulse test setup. The switching setup condition is 700 V / 80 A. This paper describes the construction of the AGD circuit and the experimental results. The over-shoot and ringing of the Vds and Is are reduced by using the active gate driver. In addition, the switching loss is simultaneously reduced.
Vascular Neointimal Formation and Signaling Pathway Activation in Response to Stent Injury in Insulin-Resistant and Diabetic Animals (2005)

Diabetes and insulin resistance are associated with increased disease risk and poor outcomes from cardiovascular interventions. Even drug-eluting stents exhibit reduced efficacy in patients with diabetes. We now report the first study of vascular response to stent injury in insulin-resistant and diabetic animal models. Endovascular stents were expanded in the aortae of obese insulin-resistant and type 2 diabetic Zucker rats, in streptozotocin-induced type 1 diabetic Sprague-Dawley rats, and in matched controls. Insulin-resistant rats developed thicker neointima (0.46+/-0.08 versus 0.37+/-0.06 mm2, P=0.05), with decreased lumen area (2.95+/-0.26 versus 3.29+/-0.15 mm2, P=0.03) 14 days after stenting compared with controls, but without increased vascular inflammation (ED1+ tissue macrophages). Insulin-resistant and diabetic rat vessels did exhibit markedly altered signaling pathway activation 1 and 2 weeks after stenting, with up to a 98% increase in p-ERK (anti-phospho ERK) and a 54% reduction in p-Akt (anti-phospho Akt) stained cells. Western blotting confirmed a profound effect of insulin resistance and diabetes on Akt and ERK signaling in stented segments. p-ERK/p-Akt ratio in stented segments uniquely correlated with neointimal response (R2=0.888, P=0.04) in insulin-resistant and type 1 and 2 diabetic rats, but not in lean controls. Transfemoral aortic stenting in rats provides insight into vascular responses in insulin resistance and diabetes. Shifts in ERK and Akt signaling related to insulin resistance may reflect altered tissue repair in diabetes accompanied by a shift in metabolic:proliferative balance. These findings may help explain the increased vascular morbidity in diabetes and suggest specific therapies for patients with insulin resistance and diabetes.
SURG-28NEUROSURGICAL INTRAOPERATIVE SPECTROSCOPY: TOWARDS REAL-TIME CNS TUMOUR BIOPSIES (2015)

Immediate, real-time accurate tissue characterisation is a crucial unmet need during surgery for the maximal resection of CNS tumours whilst causing minimum damage to surrounding functioning brain tissue. We describe the first ever use of mass spectrometry and Raman spectroscopy to immediately characterize brain tumours during surgery with accuracy rivaling that of traditional histopathological techniques. A prospective observational study was designed consisting of 40 patients undergoing Neurosurgical resection of a range of WHO grade I-IV brain tumours and metastases. A Neuronavigational platform was devised combining advanced spectrometry technologies together with intraoperative imaging to allow accurate 3D spectral acquisition during surgery taking into account brain shift. The resulting data from 40 cases consists of over 1,500 brain spectra acquired during surgery with high spatial localization. Analysis shows unique spectra for each type of tumour with sensitivity and specificity comparable to the current gold standard of histopathological analysis. The spatial heterogeneity of tumour spectra sheds important light into underlying genomic and metabolomic profiles of the tumours studied including IDH-1 mutation and MGMT status. We have demonstrated that the use of molecular data with high spatial resolution obtained through mass spectral and Raman spectral analysis shows that real-time biopsies are obtainable and represent an invaluable resource in the decision making process during surgery. This also represents an opportunity to fast track vital post surgical therapies currently offered to high grade brain tumours and investigate novel aspects of in-vivo tumour biology through a new modality with the possibility of novel biomarker discovery. This sets the stage for a formal clinical trial looking into the benefits of spectral guided resection in terms of safer and more complete resection, rapid progress to further treatment and improved overall survival.
A meta-analysis of Early Results to predict Vaccine efficacy against Omicron (2021)

Abstract In the studies to date, the estimated fold-drop in neutralisation titre against Omicron ranges from 2- to over 20-fold depending on the study and serum tested. Collating data from the first four of these studies results in a combined estimate of the drop in neutralisation titre against Omicron of 9.7-fold (95% CI 5.5-17.1). We use our previously established model to predict that six months after primary immunisation with an mRNA vaccine, efficacy for Omicron is estimated to have waned to around 40% against symptomatic and 80% against severe disease. A booster dose with an existing mRNA vaccine (even though it targets the ancestral spike) has the potential to raise efficacy for Omicron to 86.2% (95% CI: 72.6-94) against symptomatic infection and 98.2% (95% CI: 90.2-99.7) against severe infection.
A new adaptive frequency oscillator for gait assistance (2015)

To control exoskeletons for walking gait assistance, it is of primary importance to control them to act synchronously with the gaits of users. To effectively estimate the gait cycle (or the phase within a stride) of users, we propose a new adaptive frequency oscillator (AFO). While previous AFOs successfully estimated the walking frequency from joint angles as inputs, the new AFO, called particularly-shaped adaptive oscillator (PSAO) can estimate gait cycle from the same inputs, which would have required foot contact sensors in previous approaches. To predict the effects of PSAO-based gait assistance on human walking, it has been tested with neuromuscular walking simulation. In the simulation, the gait assistance system reduced the metabolic cost of walking for some assistance patterns. The walk ratio (step length per step rate) also changed as assistance patterns shifted in phase, which is meaningful because metabolic cost of walking in general is minimal at specific walk ratio. For a prototype exoskeleton we developed, the effect of gait assistance was experimented on a human subject walking on level ground and inclining slopes to verify the predictions from the simulation: (1) physiological cost index computed from heart rate significantly decreased indicating reduction in metabolic energy expenditure; (2) walk ratio was in fact controllable to an extent.
Developmental Plasticity in Tenebrio molitor (Coleoptera: Tenebrionidae): Analysis of Instar Variation in Number and Development Time under Different Diets (2010)

The variation in instar number and the pattern of sequential instar development time of Tenebrio molitor L. (Coleoptera: Tenebrionidae) was studied under 4 different diet regimes. Addition of dietary supplements consisting of dry potato or a mix of dry potato and dry egg whites significantly reduced the number of larval instars and total development time. The pattern of sequential stadia length showed regularity and low variability in instars 5 - 9. Stadia length continuously increased between instar 10 and the last instar before pupation (P−1). Instar number significantly impacted total development time and was also significantly correlated with stadia length. The length of the 1st, 2nd, 3rd, and 4th stadia was not significantly affected by diet indicating that they may represent a stable part of the life cycle of T. molitor. The length of the last stadium (P−1) was regular within food treatments regardless of sequential instar number, but P−1 was also significantly affected by nutrition in a similar way as all the sequential stadia. The pattern of instar variation is discussed in regard to the insertion of new instars based on variation of stadia length.
Investigating the impact of in-vehicle transients on diesel soot emissions (2008)

This paper describes development of a test cell setup for concurrent running of a real engine and a simulation of the vehicle system, and its use for investigating highly-dynamic engine-in-vehicle operation and its effect on diesel engine emissions. Running an engine in the test cell under conditions experienced in the vehicle enables acquiring detailed insight into dynamic interactions between power train sub-systems, and the impact of it on fuel consumption and transient emissions. This type of data may otherwise be difficult and extremely costly to obtain from a vehicle prototype test. In particular, engine system response during critical transients and the effect of transient excursions on emissions are investigated using advanced, fast-response test instrumentation and emissions analyzers. Main enablers of the work include the highly dynamic AC electric dynamometer with the accompanying computerized control system and the computationally efficient simulation of the driveline/vehicle system. The latter is developed through systematic energy-based proper modeling that tailors the virtual model to capture critical powertrain transients while running in real time. Coupling the real engine with the virtual driveline/vehicle offers a chance to easily modify vehicle parameters, and even study different power train configurations. In particular, the paper describes the engine-in-the-loop study of a V-8, 6l engine coupled to a virtual 4?4 off road vehicle. This engine is considered as a high-performance option for this truck and the real prototype of the complete vehicle does not exist yet. The results shed light on critical transients in a conventional powertrain and their effect on NOx and soot emissions. Measurements demonstrate very large spikes of particulate concentration at the initiation of vehicle acceleration events. Characterization of transients and their effect on particulate emission provides a basis for devising engine-level or vehicle level strategies, and direct guidance for developing drive-by-wire systems and/or hybrid supervisory control.
Early transvaginal embryo aspiration: a safer method for selective reduction in high order multiple gestations (1999)

Assisted reproduction technologies and ovulation induction for treatment of infertility continue to cause high order multiple gestations. Increased perinatal morbidity and mortality, as well as maternal morbidity, may complicate these pregnancies. Selective fetal reduction, an acceptable therapeutic approach in these cases, is usually performed at or after the ninth week of gestation, with KCl injected in the vicinity of the fetal heart, and is associated with a total pregnancy loss rate of 11.7%. We report our experience with 90 women who underwent early (mean 7.5 weeks gestation, range 7. 0-8.0 weeks) transvaginal selective embryo aspiration. The mean number of viable embryos before and after reduction was 3.5 and 2.1 respectively. Six (6.7%) pregnancies were lost before 24 gestational weeks. One miscarriage occurred at the tenth gestational week. The other five pregnancies were aborted at 17.3-21.6 weeks gestation. Additional interventions were performed in three of these pregnancies: genetic amniocentesis in two cases and cervical suture in one case. In the subset of 39 patients with>/=4 embryos, only one (2.6%) pregnancy loss was recorded. This loss rate is significantly lower (P < 0.05) than the 15.3% loss rate in patients with >/=4 fetuses calculated from other work. Four (4.4%) other pregnancies were complicated by premature delivery (25-28 weeks gestation). Mean gestational age of delivered pregnancies in our series was 35.7 weeks. In conclusion, early transvaginal embryo aspiration is a simple and relatively safe method for multiple pregnancy reduction. The overall pregnancy loss rate associated with early embryo aspiration is similar to that of procedures performed at later gestational age, but is significantly lower when the initial number of embryos is four or greater.
Direct Fabrication of Monodisperse Silica Nanorings from Hollow Spheres – A Template for Core–Shell Nanorings (2016)

We report a new type of nanosphere colloidal lithography to directly fabricate monodisperse silica (SiO2) nanorings by means of reactive ion etching of hollow SiO2 spheres. Detailed TEM, SEM, and AFM structural analysis is complemented by a model describing the geometrical transition from hollow sphere to ring during the etching process. The resulting silica nanorings can be readily redispersed in solution and subsequently serve as universal templates for the synthesis of ring-shaped core-shell nanostructures. As an example we used silica nanorings (with diameter of ∼200 nm) to create a novel plasmonic nanoparticle topology, a silica-Au core-shell nanoring, by self-assembly of Au nanoparticles (<20 nm) on the ring's surface. Spectroscopic measurements and finite difference time domain simulations reveal high quality factor multipolar and antibonding surface plasmon resonances in the near-infrared. By loading different types of nanoparticles on the silica core, hybrid and multifunctional composite nanoring structures could be realized for applications such as MRI contrast enhancement, catalysis, drug delivery, plasmonic and magnetic hyperthermia, photoacoustic imaging, and biochemical sensing.
Temporal shaping of optical pulses using beam coupling in a photorefractive crystal (1993)

We coupled trains of subpicosecond laser pulses in a photorefractive crystal to confirm that such coupling alters the temporal shapes of the optical pulses. Our measured pulse shapes are in good agreement with theory.
Effects of Angiotensin II on the Action Potential Durations of Atrial Myocytes in Hypertensive Rats (2005)

Angiotensin II (Ang II) has been reported to indirectly influence atrial electrical activity and to play a critical role in atrial arrhythmias in hypertensive patients. However, it is unclear whether Ang II has direct effects on the electrophysiological activity of the atrium affected by hypertension. We examined the effects of Ang II on the action potentials of atrial myocytes enzymatically isolated from spontaneous hypertensive rats (SHRs). The action potentials were recorded by the perforated patch-clamp technique and the atrial expression of the receptors AT1a and AT2 was measured by radioimmunoassay. Ang II significantly shortened the action potential durations (APDs) of SHRs without changes in the resting membrane potentials (RMPs). Pretreatment with selective AT1a blockers abolished the Ang II-induced reduction of atrial APDs of SHRs; however, a selective AT2 blocker did not, which was consistent with the results of the receptor assay. Pretreatment with phosphatidylinositol 3 (PI3)-kinase inhibitor, phospholipase C inhibitor, or protein kinase C (PKC) inhibitor abolished the Ang II-induced shortening of atrial APDs, but pertussis toxin and protein kinase A (PKA) inhibitor did not. To study the effects of chronic AT1a inhibition on Ang II-induced shortening of atrial APD, SHRs were treated with AT1a blocker for 4 weeks. AT1a blocker abolished the Ang II-induced reduction of atrial APDs of SHRs and also significantly lowered their blood pressure. In conclusion, Ang II shortened atrial APDs of SHRs via AT1a coupled with the Gq-mediated inositol triphosphate (IP3)-PKC pathway. Our findings indicated that Ang II caused atrial arrhythmias in hypertensive patients by shortening the effective refractory period of the atrium.
Transcription factor Egr-1 is required for long-term fear memory and anxiety. (2005)

The zinc finger transcription factor Egr-1 is critical for coupling extracellular signals to changes in cellular gene expression. In the hippocampus and amygdala, two major central regions for memory formation and storage, Egr-1 is up-regulated by long-term potentiation (LTP) and learning paradigms. Using Egr-1 knockout mice, we showed that Egr-1 was selectively required for late auditory fear memory while short term, trace and contextual memory were not affected. Additionally, synaptic potentiation induced by theta burst stimulation in the amygdala and auditory cortex was significantly reduced or blocked in Egr-1 knockout mice. Our study suggests that the transcription factor Egr-1 plays a selective role in late auditory fear memory.
Confidentiality in the Face of Pervasive Surveillance: A Threat Model and Problem Statement (2015)

Since the initial revelations of pervasive surveillance in 2013,
several classes of attacks on Internet communications have been
discovered. In this document, we develop a threat model that describes
these attacks on Internet confidentiality. We assume an attacker that
is interested in undetected, indiscriminate eavesdropping. The threat
model is based on published, verified attacks.
Play-Along Mapping of Musical Controllers. (2009)

We describe our tool for interactively creating musical controller mappings using a “play-along ” paradigm, in which a user pretends to play along with a musical score in real-time using an arbitrary input control modality. As the user “performs, ” a supervised machine learning system builds a training dataset from the user’s gestures and the synthesis engine’s current parameters. After one or more training stages, the algorithm learns a mapping from user inputs to synthesis parameters. Control is transferred to the user, who can then control the synthesis in real-time. 1.
Conformational study of a somatostatin analogue by high‐field n.m.r. spectroscopy, in aqueous solution (1987)

The cyclic analogue of somatostatin (SRIF), D-Phe-Cys-Tyr-D-Trp-Lys-Thr-Cys-Thr-NH2 (CTC), exhibits good affinity for both opioid and SRIF receptor systems. Its conformational properties were examined in water by high-field proton n.m.r. spectroscopy and compared with results previously obtained with structurally related analogues SMS 201-995 and Sandoz 204-090 in the same solvent. The assignments were made using 2 D-n.m.r. methods, especially long-range connectivities between neighbouring alpha protons, and between beta and aromatic protons. The 3JNH-C alpha H and delta delta/delta T values are compatible with an equilibrium between two gamma turns involving residues 2, 3 and 4 and residues 3, 4, and 5, respectively.