gebhart/patrepeval huggingface dataset:
Test Zone Size Characterization With Measured MIMO Throughput for Simulated MPAC Configurations in Conductive Setups (2017)

This correspondence discusses over-the-air (OTA) testing for multiple-input multiple-output (MIMO) capable terminals, with an emphasis on test zone size characterization for multi-probe anechoic chamber (MPAC) OTA configurations. For an MPAC setup, it is important to understand the test zone size that can be supported by its design. Further, it is desirable that the test zone size should be determined in terms of measured throughput deviation. However, such works have not been reported in the literature yet, due to challenges in practical MPAC setups. In this correspondence, we propose to simulate the MPAC OTA configuration and MS design in a channel emulator and perform MIMO throughput measurements in a conductive setup. With the proposed scheme, we can investigate how large a test zone can be supported for the synthetic MPAC configuration in terms of throughput deviation. This scheme is attractive, since various MS antenna designs and MPAC configurations can be flexibly selected and test zone size in terms of measured MIMO throughput deviation can be achieved. Measurement results show that with a high antenna correlation at the base station (BS) side, measured throughput results would be low, irrelevant to MPAC OTA designs and antenna designs at the MS side. Therefore, the antenna correlation at BS side should be set uncorrelated to ensure that true MS performance can be measured. Further, spatial correlation accuracy at the MS side becomes critical for throughput accuracy only when correlation values are in the high region (e.g., ρ > 0.5).
Robust Satisfaction of Metric Interval Temporal Logic Objectives in Adversarial Environments (2023)

This paper studies the synthesis of controllers for cyber-physical systems (CPSs) that are required to carry out complex time-sensitive tasks in the presence of an adversary. The time-sensitive task is specified as a formula in the metric interval temporal logic (MITL). CPSs that operate in adversarial environments have typically been abstracted as stochastic games (SGs); however, because traditional SG models do not incorporate a notion of time, they cannot be used in a setting where the objective is time-sensitive. To address this, we introduce durational stochastic games (DSGs). DSGs generalize SGs to incorporate a notion of time and model the adversary’s abilities to tamper with the control input (actuator attack) and manipulate the timing information that is perceived by the CPS (timing attack). We define notions of spatial, temporal, and spatio-temporal robustness to quantify the amounts by which system trajectories under the synthesized policy can be perturbed in space and time without affecting satisfaction of the MITL objective. In the case of an actuator attack, we design computational procedures to synthesize controllers that will satisfy the MITL task along with a guarantee of its robustness. In the presence of a timing attack, we relax the robustness constraint to develop a value iteration-based procedure to compute the CPS policy as a finite-state controller to maximize the probability of satisfying the MITL task. A numerical evaluation of our approach is presented on a signalized traffic network to illustrate our results.
False Results Caused by Solvent Impurity in Tetrahydrofuran for MALDI TOF MS Analysis of Amines (2013)

Tetrahydrofuran (THF) is one of the most frequently used solvents in the MALDI TOF MS analysis of synthetic compounds. However, it should be used with caution because a trace amount of 4-hydroxybutanal (HBA) might be generated and accumulated in THF during storage. Since only a tiny amount of analytes is required in MALDI MS measurements, a trace amount of HBA might have a significant effect on the MS results. It was found that HBA will quickly react with primary and secondary amino compounds, leading to false results about the sample composition with an extra series of ions with additional mass of 70 Da in between. The formation of HBA can be inhibited by butylated hydroxytoluene (BHT) antioxidant. Therefore, when THF is required as the solvent for sample preparation, it is strongly recommended to use a BHT-stabilized one, at least for the analysis of compounds with amino groups.
Current Status, Problems, Future Technology for Rechargeable Batteries (2019)

Introduction of natural energy and electric vehicles have been extensively progressed in order to reduce carbon dioxide emission from our human society. The emission of carbon dioxide leads to grovel warming. The electric energy without carbon dioxide emission should be produced from natural energy and utilized in vehicles. Therefore, a smart grid and electric vehicle are very important applications. In both applications, rechargeable batteries play an important role. So far, lithium ion battery has been applied to such applications. However, lithium ion battery may not be enough performances. In order to realize high performance of rechargeable batteries, new next generation batteries have been developed, extensively.
Ultrathin Photo‐Oxidized Siloxane Layer for Extreme Wettability: Anti‐Fogging Layer for Spectacles (2016)

The ultrathin low-molecular-weight (LMW) polydimethylsiloxane (PDMS) layer clearly provides chemical extreme wettability without any change of physical parameters. Contact printing of a PDMS stamp can easily achieve a layer, which induces numerous hydroxyl groups via photochemical oxidation. The layer-induced extreme wettability exhibits a superior antifogging performance on spectacle lenses without any effects on the optical prescription. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
A new isomaneonene derivative from the red alga Laurencia cf. mariannensis (2022)

Determining the structures of new natural products from marine species not only enriches our understanding of the diverse chemistry of these species, but can also lead to the discovery of compounds with novel and/or important biological activities. Herein, we describe the isolation of isomaneonene C (<b>1</b>), a new halogenated C<sub>15</sub> acetogenin, and three known compounds, <i>α</i>-snyderol (<b>2</b>), <i>cis</i>-maneonene D (<b>3</b>), and isomaneonene B (<b>4</b>), from the organic extract obtained from the red alga <i>Laurencia</i> cf. <i>mariannensis</i> collected from Iheya Island, Okinawa, Japan. The structures of these secondary metabolites were elucidated spectroscopically. All compounds were inactive at 30 μg/disc against methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) in combination treatment with a β<b>-</b>lactam drug, meropenem.
Isorhamnetin induces ROS-dependent cycle arrest at G2/M phase and apoptosis in human hepatocarcinoma Hep3B cells (2019)

Isorhamnetin is a 3'-O-methylated metabolite of quercetin that is found predominantly in a variety of medicinal plants. Although many previous studies have reported that this flavonol has diverse health-promoting effects, evidence for the underlying molecular mechanism of anti-cancer efficacy is still lacking. In this study, it was examined the anti-proliferative effect of isorhamnetin on human hepatocarcinoma Hep3B cells, and found that isorhamnetin induced cell cycle arrest at G2/M phase and apoptosis. Isorhamnetin-induced G2/M arrest was associated with decreased expression of proliferating cell nuclear antigen as well as cyclin A and cyclin B1. However, isorhamnetin increased expression of p21WAF1/CIP1, a cyclin-dependent kinase (Cdk) inhibitor, and increased p21 complexed with Cdk2 and Cdc2. In addition, Isorhamnetin-induced apoptosis was associated with increased expression of Fas/Fas ligand, reduced ratio of Bcl-2/Bax expression, truncation of Bid, cytosolic release of cytochrome c, and activation of caspase-8, -9 and -3. Isorhamnetin also enhanced intracellular levels of reactive oxygen species (ROS), while the addition of N-acetyl cysteine (NAC), a ROS inhibitor, significantly diminished isorhamnetin-induced mitochondrial dysfunction. Furthermore, the interruption of ROS generation using NAC significantly attenuated isorhamnetin-mediated G2/M arrest and apoptosis. Collectively, this is the first report to show that isorhamnetin inhibited the proliferation of human hepatocarcinoma cells by ROS-dependent arrest of the cell cycle at the G2/M phase and induction of apoptosis.
GenCos' participation in the unbundled energy market (2005)

In this document we analyze market producers' participation in the new unbundled energy market. The electricity market is in the process of unbundling the ancillary services. In a fully unbundled electricity market more extensive analysis needs to be performed given that market participation is not restricted to electricity production. Ancillary services were bundled within the integrated generation and transmission services in the vertical integrated industry. Instead of being bundled with generation and transmission, the individual services are now uniquely identified in the competitive markets. In this new market environment, the decision making process can be seen as an activity analysis problem. Market participants will need to determine the most probable and profitable future market actions based on the last known market data and market projection.
Synthesis of Novel Mammalian Metabolites of the Isoflavonoid Phytoestrogens Daidzein and Genistein (1998)

The synthesis of novel mammalian metabolites of dietary isoflavones, dihydrodaidzein (4',7-dihydroxyisoflavanone) 7, dihydrogenistein (4',5,7-trihydroxyisoflavanone) 9, 6'-hydroxy-O-demethylangolensin [1-(2,4,6-trihydroxyphenyl)-2-(4-hydroxyphenyl)propan-1-one] 10, and cis- and trans-4',7-dihydroxyisoflavan-4-ols 11, 12 is described, and their characteristics by physical and chemical constants given for the first time.
An exercise trial targeting posterior shoulder strength in manual wheelchair users: pilot results and lessons learned (2014)

There is biomechanical reason to believe that rowing exercises may improve shoulder muscle balance in this population, which could reduce the risk of impingement. This may be of benefit to manual wheelchair users, who are at high risk for shoulder injury. Implications for Rehabilitation Regular exercise improves cardiorespiratory fitness and did not exacerbate shoulder pain in this group of manual wheelchair users. Exercises that target posterior shoulder muscle groups, such as rowing, may improve muscle balance and reduce the risk of shoulder impingement. Participation in exercise is hindered in this population by a high rate of secondary health conditions and difficulty accessing facilities and equipment.
Multiple Anti-Interferon Actions of the Influenza A Virus NS1 Protein (2007)

The replication and pathogenicity of influenza A virus (FLUAV) are controlled in part by the alpha/beta interferon (IFN-alpha/beta) system. This virus-host interplay is dependent on the production of IFN-alpha/beta and on the capacity of the viral nonstructural protein NS1 to counteract the IFN system. Two different mechanisms have been described for NS1, namely, blocking the activation of IFN regulatory factor 3 (IRF3) and blocking posttranscriptional processing of cellular mRNAs. Here we directly compare the abilities of NS1 gene products from three different human FLUAV (H1N1) strains to counteract the antiviral host response. We found that A/PR/8/34 NS1 has a strong capacity to inhibit IRF3 and activation of the IFN-beta promoter but is unable to suppress expression of other cellular genes. In contrast, the NS1 proteins of A/Tx/36/91 and of A/BM/1/18, the virus that caused the Spanish influenza pandemic, caused suppression of additional cellular gene expression. Thus, these NS1 proteins prevented the establishment of an IFN-induced antiviral state, allowing virus replication even in the presence of IFN. Interestingly, the block in gene expression was dependent on a newly described NS1 domain that is important for interaction with the cleavage and polyadenylation specificity factor (CPSF) component of the cellular pre-mRNA processing machinery but is not functional in A/PR/8/34 NS1. We identified the Phe-103 and Met-106 residues in NS1 as being critical for CPSF binding, together with the previously described C-terminal binding domain. Our results demonstrate the capacity of FLUAV NS1 to suppress the antiviral host defense at multiple levels and the existence of strain-specific differences that may modulate virus pathogenicity.
Spread spectrum slot reservation multiple access (2002)

A new method of data transmission is proposed for mobile communications. It is similar to the traditional split channel reservation multiple access (SRMA): a mobile user (MU) reserves transmission slots from a base station (BS) and then transmits according to the BS scheduling. However, in the proposed method a number of MUs can transmit concurrently using the direct sequence spread spectrum (DS-SS) technique. The DS-SS technique is also used at the reservation stage where a multiple-slotted-ALOHA (m-S-ALOHA) technique allows multiple users to simultaneously reserve service. Theoretical and simulation results show significant increases in throughput efficiency for the proposed method compared with the traditional SRMA technique.
Platelets Having a W127X Mutation in GPIX Express Sufficient Residual Amounts of the GPIbα Chain to Support Ristocetin-Mediated Agglutination and Adhesion to VWF and Collagen Under Conditions of Flow. (2008)

Abstract A W127X mutation in platelet glycoprotein (GP)IX is the most common genetic defect in Japanese Bernard-Soulier Syndrome (BSS). Patients having this mutation are often misdiagnosed as having immune thrombocytopenia (ITP) because of residual expression of GPIbα on the platelet surface. The purpose of the present investigation was to determine whether the residual amount of GPIbα present on the surface of GPIXW127X BSS platelets might be sufficient to support adhesive functions of the GPIb complex. Flow cytometric analysis of platelets from our GPIXW127X BSS patient revealed 7–11% of the normal level of GPIbα (3,700 receptors/platelet), although the expression of GPIbα estimated by western blot analysis was only 1% of normal. Expression levels of other receptors such as GPIIb, GPVI, and α2 integrin were 3–4 times higher per platelet than that of normal controls–probably due to the increased size of the BSS platelets. To characterize the ability of GPIXW127X BSS platelets to bind VWF, we evaluated their agglutination in the presence of various concentrations of ristocetin, and found that ristocetin-induced agglutination was absent at 1.2 and 1.5 mg of ristocetin/ml, but present at 2.0 mg/ml. We then evaluated the ability of GPIXW127X BSS platelets to adhere under conditions of flow to immobilized VWF, type 1 collagen, and type III collagen. Whereas platelets derived from a Type I BSS patient having a TGTG deletion within the GPIbα gene in which GPIbα is completely absent (Thrombosis and Haemost 77:1055,1997) were unable to adhere to immobilized VWF under conditions of high shear, GPIXW127X BSS platelets bound well, demonstrating that the residual amount of GPIbα present GPIXW127X BSS platelets is sufficient to mediate adhesion to VWF. Finally, recent studies (J Thromb Haemost 5:797,2007) have shown that platelet adhesion to Type III collagen can be mediated by either interaction of GPIbα with VWF, or by interaction of the integrin α2β1 with collagen under high shear flow. In support of this notion, adhesion of GPIbαTGTG del BSS platelets to immobilized Type III collagen could be completely inhibited by addition of the anti-α2β1 blocking mAb, Gi9, while adhesion of GPIXW127X BSS platelets to Type III collagen was only marginally affected. Taken together, we conclude that platelets having a W127X mutation in GPIX express residual amounts of functional GPIbα, and both GPIb-VWF and integrin α2β1-collagen interactions are physiologically important under conditions of high shear stress. Residual expression of GPIbα in GPIXW127X platelets, therefore, likely accounts for the relatively mild bleeding phenotype in this variant form of BSS.
Wide spectrum of neuronal and network phenotypes in human stem cell-derived excitatory neurons with Rett syndrome-associated MECP2 mutations (2022)

Rett syndrome (RTT) is a severe neurodevelopmental disorder primarily caused by heterozygous loss-of-function mutations in the X-linked gene MECP2 that is a global transcriptional regulator. Mutations in the methyl-CpG binding domain (MBD) of MECP2 disrupt its interaction with methylated DNA. Here, we investigate the effect of a novel MECP2 L124W missense mutation in the MBD of an atypical RTT patient with preserved speech in comparison to severe MECP2 null mutations. L124W protein had a limited ability to disrupt heterochromatic chromocenters due to decreased binding dynamics. We isolated two pairs of isogenic WT and L124W induced pluripotent stem cells. L124W induced excitatory neurons expressed stable protein, exhibited increased input resistance and decreased voltage-gated Na<sup>+</sup> and K<sup>+</sup> currents, and their neuronal dysmorphology was limited to decreased dendritic complexity. Three isogenic pairs of MECP2 null neurons had the expected more extreme morphological and electrophysiological phenotypes. We examined development and maturation of L124W and MECP2 null excitatory neural network activity using micro-electrode arrays. Relative to isogenic controls, L124W neurons had an increase in synchronous network burst frequency, in contrast to MECP2 null neurons that suffered a significant decrease in synchronous network burst frequency and a transient extension of network burst duration. A biologically motivated computational neural network model shows the observed changes in network dynamics are explained by changes in intrinsic Na<sup>+</sup> and K<sup>+</sup> currents in individual neurons. Our multilevel results demonstrate that RTT excitatory neurons show a wide spectrum of morphological, electrophysiological and circuitry phenotypes that are dependent on the severity of the MECP2 mutation.
ChemInform Abstract: Total Syntheses of Enantiomerically Pure D‐ and L‐Glycosyl Donors as Components of Sannamycin‐Type Aminoglycoside Antibiotics. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Automatic Identification of Important Segments and Expressions for Mining of Business-Oriented Conversations at Contact Centers (2007)

Textual records of business-oriented conversations between customers and agents need to be analyzed properly to acquire useful business insights that improve productivity. For such an analysis, it is critical to identify appropriate textual segments and expressions to focus on, especially when the textual data consists of complete transcripts, which are often lengthy and redundant. In this paper, we propose a method to identify important segments from the conversations by looking for changes in the accuracy of a categorizer designed to separate different business outcomes. We extract effective expressions from the important segments to define various viewpoints. In text mining a viewpoint defines the important associations between key entities and it is crucial that the correct viewpoints are identified. We show the effectiveness of the method by using real datasets from a car rental service center. 1
Stable long-term BCI-enabled communication in ALS and locked-in syndrome using LFP signals (2018)

Restoring communication for people with locked-in syndrome remains a challenging clinical problem without a reliable solution. Recent studies have shown that people with paralysis can use brain-computer interfaces (BCIs) based on intracortical spiking activity to efficiently type messages. However, due to neuronal signal instability, most intracortical BCIs have required frequent calibration and continuous assistance of skilled engineers to maintain performance. Here, an individual with locked-in syndrome due to brain stem stroke and an individual with tetraplegia secondary to amyotrophic lateral sclerosis (ALS) used a simple communication BCI based on intracortical local field potentials (LFPs) for 76 and 138 days, respectively, without recalibration and without significant loss of performance. BCI spelling rates of 3.07 and 6.88 correct characters/minute allowed the participants to type messages and write emails. Our results indicate that people with locked-in syndrome could soon use a slow but reliable LFP-based BCI for everyday communication without ongoing intervention from a technician or caregiver. NEW & NOTEWORTHY This study demonstrates, for the first time, stable repeated use of an intracortical brain-computer interface by people with tetraplegia over up to four and a half months. The approach uses local field potentials (LFPs), signals that may be more stable than neuronal action potentials, to decode participants' commands. Throughout the several months of evaluation, the decoder remained unchanged; thus no technical interventions were required to maintain consistent brain-computer interface operation.
<title>Visualizing multiattribute Web transactions using a freeze technique</title> (2003)

Web transactions are multidimensional and have a number of attributes: client, URL, response times, and numbers of messages. One of the key questions is how to simultaneously lay out in a graph the multiple relationships, such as the relationships between the web client response times and URLs in a web access application. In this paper, we describe a <i>freeze</i> technique to enhance a physics-based visualization system for web transactions. The idea is to freeze one set of objects before laying out the next set of objects during the construction of the graph. As a result, we substantially reduce the force computation time. This technique consists of three steps: automated <i>classification</i>, a <i>freeze operation</i>, and <i>a graph layout</i>. These three steps are iterated until the final graph is generated. This iterated-freeze technique has been prototyped in several e-service applications at Hewlett Packard Laboratories. It has been used to visually analyze large volumes of service and sales transactions at online web sites.
Evolution of Intracellular Pathogens (2008)

The evolution of intracellular pathogens is considered in the context of ambiguities in basic definitions and the diversity of host-microbe interactions. Intracellular pathogenesis is a subset of a larger world of host-microbe interactions that includes amoeboid predation and endosymbiotic existence. Intracellular pathogens often reveal genome reduction. Despite the uniqueness of each host-microbe interaction, there are only a few general solutions to the problem of intracellular survival, especially in phagocytic cells. Similarities in intracellular pathogenic strategies between phylogenetically distant microbes suggest convergent evolution. For discerning such patterns, it is useful to consider whether the microbe is acquired from another host or directly from the environment. For environmentally acquired microbes, biotic pressures, such as amoeboid predators, may select for the capacity for virulence. Although often viewed as a specialized adaptation, the capacity for intracellular survival may be widespread among microbes, thus questioning whether the intracellular lifestyle warrants a category of special distinctiveness.