gebhart/patrepeval huggingface dataset:
Behavior Modeling and Digital Predistortion of Mismatched Wireless Transmitters Using Convolutional Neural Networks (2022)

In modern wireless compact transmitters, Power Amplifier (PA) behavior is considerably affected by the impedance mismatch between the PA’s output and the antenna’s input. This PA’s output mismatch results in a reflection at the PA–antenna interface. In this brief, reflection-aware PA modeling and digital predistortion (DPD) techniques are proposed to mitigate the negative impact of this mismatch on the forward and reverse models of the PA. An Augmented Convolutional neural network model <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$(\boldsymbol{\Gamma }$ </tex-math></inline-formula> ACNN) is proposed to linearize a Doherty PA under different values of the output mismatch using a single set of coefficients. The developed DPD shows robust performance metrics like normalized mean square error (NMSE), and adjacent channel power ratio (ACPR) under diverse complex output mismatch levels.
Subgingival microbiome at different levels of cognition (2023)

Oral health and declining cognition may have a bi-directional association. We characterized the subgingival microbiota composition of subjects from normal cognition to severe cognitive decline in two cohorts. Memory and Periodontitis (MINOPAR) include 202 home-living participants (50-80 years) in Sweden. Finnish Oral Health Studies in Older Adults (FINORAL) include 174 participants (≥65 years) living in long-term care in Finland. We performed oral examination and assessed the cognitive level with Mini Mental State Examination (MMSE). We sequenced the 16S-rRNA gene (V3-V4 regions) to analyse the subgingival bacterial compositions. The microbial diversities only tended to differ between the MMSE categories, and the strongest determinants were increased probing pocket depth (PPD) and presence of caries. However, abundances of 101 taxa were associated with the MMSE score. After adjusting for age, sex, medications, PPD, and caries, only eight taxa retained the significance in the meta-analyses of the two cohorts. Especially <i>Lachnospiraceae</i> [XIV] at the family, genus, and species level increased with decreasing MMSE. Cognitive decline is associated with obvious changes in the composition of the oral microbiota. Impaired cognition is accompanied with poor oral health status and the appearance of major taxa of the gut microbiota in the oral cavity. Good oral health-care practices require special deliberations among older adults.
Rectangle FRAP for Measuring Diffusion with a Laser Scanning Microscope (2013)

Fluorescence recovery after photobleaching (FRAP) is one of the most useful microscopy techniques for studying the mobility of molecules in terms of a diffusion coefficient. Here, we describe a FRAP method that allows such measurements, relying on the photobleaching of a rectangular region of any size and aspect ratio. We start with a brief overview of the rectangle FRAP theory, and next we provide guidelines for performing FRAP measurements, including a discussion of the experimental setup and the data analysis. Finally, we discuss how to verify correct use of the rectangle FRAP method using test solutions.
VRFP: On-the-Fly Video Retrieval Using Web Images and Fast Fisher Vector Products (2017)

On-the-fly video retrieval using Web images and fast Fisher Vector products (VRFP) is a real-time video retrieval framework based on short text input queries, which obtains weakly labeled training images from the Web after the query is known. The retrieved Web images representing the query and each database video are treated as unordered collections of images, and each collection is represented using a single Fisher Vector built on CNN features. Our experiments show that a Fisher Vector is robust to noise present in Web images and compares favorably in terms of accuracy to other standard representations. While a Fisher Vector can be constructed efficiently for a new query, matching against the test set is slow due to its high dimensionality. To perform matching in real time, we present a lossless algorithm that accelerates the inner product computation between high-dimensional Fisher Vectors. We prove that the expected number of multiplications required decreases quadratically with the sparsity of Fisher Vectors. We are not only able to construct and apply query models in real time, but with the help of a simple reranking scheme, we also outperform state-of-the-art automatic retrieval methods by a significant margin on TRECVID MED13 (3.5%), MED14 (1.3%), and CCV datasets (5.2%). We also provide a direct comparison on standard datasets between two different paradigms for automatic video retrieval: zero-shot learning and on-the-fly retrieval.
Mature Glycosylation and Trafficking of Nicastrin Modulate Its Binding to Presenilins (2002)

Nicastrin is an integral component of the high molecular weight presenilin complexes that control proteolytic processing of the amyloid precursor protein and Notch. We report here that nicastrin is most probably a type 1 transmembrane glycoprotein that is expressed at moderate levels in the brain and in cultured neurons. Immunofluorescence studies demonstrate that nicastrin is localized in the endoplasmic reticulum, Golgi, and a discrete population of vesicles. Glycosidase analyses reveal that endogenous nicastrin undergoes a conventional, trafficking-dependent maturation process. However, when highly expressed in transfected cells, there is a disproportionate accumulation of the endo-beta-N-acetylglucosaminidase H-sensitive, immature form, with no significant increase in the levels of the fully mature species. Immunoprecipitation revealed that presenilin-1 interacts preferentially with mature nicastrin, suggesting that correct trafficking and co-localization of the presenilin complex components are essential for activity. These findings demonstrate that trafficking and post-translational modifications of nicastrin are tightly regulated processes that accompany the assembly of the active presenilin complexes that execute gamma-secretase cleavage. These results also underscore the caveat that simple overexpression of nicastrin in transfected cells may result in the accumulation of large amounts of the immature protein, which is apparently unable to assemble into the active complexes capable of processing amyloid precursor protein and Notch.
Integrated cardio-behavioral responses to threat define defensive states (2023)

Fear and anxiety are brain states that evolved to mediate defensive responses to threats. The defense reaction includes multiple interacting behavioral, autonomic and endocrine adjustments, but their integrative nature is poorly understood. In particular, although threat has been associated with various cardiac changes, there is no clear consensus regarding the relevance of these changes for the integrated defense reaction. Here we identify rapid microstates that are associated with specific behaviors and heart rate dynamics, which are affected by long-lasting macrostates and reflect context-dependent threat levels. In addition, we demonstrate that one of the most commonly used defensive behavioral responses-freezing as measured by immobility-is part of an integrated cardio-behavioral microstate mediated by Chx10<sup>+</sup> neurons in the periaqueductal gray. Our framework for systematic integration of cardiac and behavioral readouts presents the basis for a better understanding of complex neural defensive states and their associated systemic functions.
Outcomes of a technique combining diaphyseal impaction grafting and metaphyseal cones for severe bone loss in revision total knee arthroplasty (2020)

When presented with a sclerotic diaphysis and substantial metaphyseal bone loss, this technique combining diaphyseal impaction grafting with a metaphyseal cone provided near universal success in relation to implant fixation. Moreover, radiographs revealed incorporation of the bone graft and biological fixation of the cone. While long-term follow-up will be important, this technique provides an excellent option for the management of complex revision TKAs. Cite this article: <i>Bone Joint J</i> 2020;102-B(6 Supple A):116-122.
Efficacy of vaccination with recombinant vaccinia and fowlpox vectors expressing NY-ESO-1 antigen in ovarian cancer and melanoma patients (2012)

Recombinant poxviruses (vaccinia and fowlpox) expressing tumor-associated antigens are currently being evaluated in clinical trials as cancer vaccines to induce tumor-specific immune responses that will improve clinical outcome. To test whether a diversified prime and boost regimen targeting NY-ESO-1 will result in clinical benefit, we conducted two parallel phase II clinical trials of recombinant vaccinia-NY-ESO-1 (rV-NY-ESO-1), followed by booster vaccinations with recombinant fowlpox-NY-ESO-1 (rF-NY-ESO-1) in 25 melanoma and 22 epithelial ovarian cancer (EOC) patients with advanced disease who were at high risk for recurrence/progression. Integrated NY-ESO-1-specific antibody and CD4(+) and CD8(+) T cells were induced in a high proportion of melanoma and EOC patients. In melanoma patients, objective response rate [complete and partial response (CR+PR)] was 14%, mixed response was 5%, and disease stabilization was 52%, amounting to a clinical benefit rate (CBR) of 72% in melanoma patients. The median PFS in the melanoma patients was 9 mo (range, 0-84 mo) and the median OS was 48 mo (range, 3-106 mo). In EOC patients, the median PFS was 21 mo (95% CI, 16-29 mo), and median OS was 48 mo (CI, not estimable). CD8(+) T cells derived from vaccinated patients were shown to lyse NY-ESO-1-expressing tumor targets. These data provide preliminary evidence of clinically meaningful benefit for diversified prime and boost recombinant pox-viral-based vaccines in melanoma and ovarian cancer and support further evaluation of this approach in these patient populations.
Cationic Polysaccharides for Gene Delivery (2002)

Cationic polysaccharides based on spermine−dextran conjugates were synthesized and tested as vectors for gene transfection. Dextrans of 10−380 kDa were oxidized under mild conditions by potassium periodate to obtain the respective polyaldehydes in 90% overall yield. The oxidized dextrans were reacted by reductive amination with increasing amounts of spermine, and the efficacy of conjugation between the oligoamine and polysaccharides was studied as a function of spermine/aldehyde mole ratio, pH, and temperature of medium. The optimal conjugation yields were obtained at 1.25 mole ratio (spermine/aldehyde groups) and pH 11 at room temperature. Under these conditions, ∼2 μmol/mg (spermine/polysaccharide) conjugation was achieved with 25−30% of the spermine moieties were conjugated in both sides to form branched polymers. The water-soluble polymers obtained were interacted with pCMV-GFP plasmid to form nanoparticles that were introduced to HEK293 and NIH3T3 cells in vitro for transfection efficacy assessment. Out of about 50 different polymer structures, only spermine−dextran of 6000−8000 Da, spermine content of ∼2 μmol/mg, and degree of branching of 25−30% was active in transfecting about 50% of the cells while all other polymers were significantly less active.
Structure of uracil-DNAN-glycosylase (UNG) fromVibrio cholerae: mapping temperature adaptation through structural and mutational analysis (2010)

The crystal structure of Vibrio cholerae uracil-DNA N-glycosylase (vcUNG) has been determined to 1.5 A resolution. Based on this structure, a homology model of Aliivibrio salmonicida uracil-DNA N-glycosylase (asUNG) was built. A previous study demonstrated that asUNG possesses typical cold-adapted features compared with vcUNG, such as a higher catalytic efficiency owing to increased substrate affinity. Specific amino-acid substitutions in asUNG were suggested to be responsible for the increased substrate affinity and the elevated catalytic efficiency by increasing the positive surface charge in the DNA-binding region. The temperature adaptation of these enzymes has been investigated using structural and mutational analyses, in which mutations of vcUNG demonstrated an increased substrate affinity that more resembled that of asUNG. Visualization of surface potentials revealed a more positive potential for asUNG compared with vcUNG; a modelled double mutant of vcUNG had a potential around the substrate-binding region that was more like that of asUNG, thus rationalizing the results obtained from the kinetic studies.
Suicide After Mohs Surgery (2020)

*University of California, Irvine, School of Medicine, Irvine, California †Private Practice, Child and Adult Psychiatry, Newport Beach, California ‡Department of Dermatology, University of California, Irvine, Irvine, California §Private Practice, Newport Skin Cancer, Newport Beach, California The authors have indicated no significant interest with commercial supporters.
Singlemode operation over range –40 –85°C in1.55 µm gain-coupled DFB lasers (1995)

Singlemode operation of 1.55 µm gain-coupled DFB lasers with a large sidemode suppression ratio over a wide temperature range of –40 – 85°C is reported. The structure was based on eight compressively strained multiquantum wells for high temperature operations and a first-order grating partially etched into the quantum wells for lasing wavelength control.
A Multitask Deep-Learning System to Classify Diabetic Macular Edema for Different Optical Coherence Tomography Devices: A Multicenter Analysis (2021)

&lt;a&gt;&lt;b&gt;Objective:&lt;/b&gt;&lt;/a&gt; Diabetic macular edema (DME) is the primary cause of vision loss among individuals with diabetes mellitus (DM). We developed, validated, and tested a deep-learning (DL) system for classifying DME using images from three common commercially available optical coherence tomography (OCT) devices. &lt;p&gt;&lt;b&gt;Research Design and Methods:&lt;/b&gt; We trained and validated two versions of a multi-task convolution neural network (CNN) to classify DME (center-involved DME [CI-DME], non-CI-DME, or absence of DME) using three-dimensional (3D) volume-scans and two-dimensional (2D) B-scans respectively. For both 3D and 2D CNNs, we employed the residual network (ResNet) as the backbone. For the 3D CNN, we used a 3D version of ResNet-34 with the last fully connected layer removed as the feature extraction module. A total of 73,746 OCT images were used for training and primary validation. External testing was performed using 26,981 images across seven independent datasets from Singapore, Hong Kong, the US, China, and Australia. &lt;/p&gt; &lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; In classifying the presence or absence of DME, the DL system achieved area under the receiver operating characteristic curves (AUROCs) of 0.937 (95% CI 0.920–0.954), 0.958 (0.930–0.977), and 0.965 (0.948–0.977) for primary dataset obtained from Cirrus, Spectralis, and Triton OCTs respectively, in addition to AUROCs greater than 0.906 for the external datasets. For the further classification of the CI-DME and non-CI-DME subgroups, the AUROCs were 0.968 (0.940–0.995), 0.951 (0.898–0.982), and 0.975 (0.947–0.991) for the primary dataset and greater than 0.894 for the external datasets. &lt;/p&gt; &lt;p&gt;&lt;b&gt;Conclusion:&lt;/b&gt; We demonstrated excellent performance with a DL system for the automated classification of DME, highlighting its potential as a promising second-line screening tool for patients with DM, which may potentially create a more effective triaging mechanism to eye clinics. &lt;/p&gt;
Transgenes expressing the Wnt-1 and int-2 proto-oncogenes cooperate during mammary carcinogenesis in doubly transgenic mice. (1992)

The Wnt-1 and int-2 proto-oncogenes are transcriptionally activated by mouse mammary tumor virus insertion mutations in virus-induced tumors and encode secretory glycoproteins. To determine whether these two genes can cooperate during carcinogenesis, we have crossed two previously characterized lines of transgenic mice to obtain bitransgenic animals carrying both Wnt-1 and int-2 transgenes under the control of the mouse mammary tumor virus long terminal repeat. Mammary carcinomas appear earlier and with higher frequency in the bitransgenic animals, especially the males, than in either parental line. Nearly all bitransgenic males develop mammary neoplasms within 8 months of birth, whereas only 15% of Wnt-1 transgenic males and none of the int-2 transgenic males have tumors. In virgin bitransgenic females, tumors occur approximately 2 months earlier than in their Wnt-1 transgenic siblings; int-2 transgenic females rarely exhibit tumors. Preneoplastic glands from the bitransgenic animals of either sex demonstrate pronounced epithelial hyperplasia similar to that seen in Wnt-1 transgenic virgin females and males, and both transgenes are expressed in the hyperplastic glands and mammary tumors. RNA from the int-2 transgene is more abundant in mammary glands from bitransgenic animals than from int-2 transgenic animals; the increase is associated with high levels of RNA specific for keratin genes 14 and 18, suggesting that Wnt-1-induced epithelial hyperplasia is responsible for the observed increase in expression of the int-2 transgene.
Active plasmonic optoelectronics (2021)

In this talk I will discuss our group’s work on the design, growth, fabrication and characterization of a new class of all-epitaxial plasmonic optoelectronic devices with enhanced performance when compared to state-of-the-art infrared optoelectronics. Specifically, we demonstrate that highly doped semiconductors, serving as ‘designer’ plasmonic materials, can be monolithically integrated with a range of infrared optoelectronic device architectures to provide strong field confinement, and enhanced emission, detection, and potentially modulation capabilities in the mid-infrared. We will present results from long-wave infrared detectors with thickness of only 350 nm, capable of over 50% external quantum efficiency and state-of-the-art detectivity, as well as dual color detectors, spectrally-selective detectors, and enhanced efficiency emitters leveraging our designer plasmonic materials with a range of novel device architectures.
Automated polarization control demonstrated in a 1.28 Tbit/s (16×2×40 Gbit/s) polarization multiplexed DWDM field trial (2002)

We have demonstrated automatic polarization control in a field trial over 116 km of SSMF with 16 channel DWDM (100 GHz spacing) based on polarization multiplexed 2/spl times/40 Gbit/s NRZ signals for a total capacity of 1.28 Tbit/s after FEC decoding.
Evidence-based trust (2010)

An evidence-based account of trust is essential for an appropriate treatment of application-level interactions among autonomous and adaptive parties. Key examples include social networks and service-oriented computing. Existing approaches either ignore evidence or only partially address the twin challenges of mapping evidence to trustworthiness and combining trust reports from imperfectly trusted sources. This article develops a mathematically well-formulated approach that naturally supports discounting and combining evidence-based trust reports. This article understands an agent Alice's trust in an agent Bob in terms of Alice's certainty in her belief that Bob is trustworthy. Unlike previous approaches, this article formulates certainty in terms of evidence based on a statistical measure defined over a probability distribution of the probability of positive outcomes. This definition supports important mathematical properties ensuring correct results despite conflicting evidence: (1) for a fixed amount of evidence, certainty increases as conflict in the evidence decreases and (2) for a fixed level of conflict, certainty increases as the amount of evidence increases. Moreover, despite a subtle definition of certainty, this work (3) establishes a bijection between evidence and trust spaces, enabling robust combination of trust reports and (4) provides an efficient algorithm for computing this bijection.
Synthesis and Antimicrobial Screening of Some Novel 2‐(5‐(4‐(1H‐Benzo[d][1,2,3]triazol‐1‐yl)phenyl)‐4,5‐dihydro‐1H‐pyrazol‐3‐yl)phenols Incorporated by Triazole Moiety (2013)

A novel series of 2‐(5‐(4‐(1 H ‐benzo[ d ][1,2,3]triazol‐1‐yl)phenyl)‐4,5‐dihydro‐1 H ‐pyrazol‐3‐yl)phenols derivative has been synthesized from ( E )‐3‐(4‐(1 H ‐benzo[ d ][1,2,3]triazol‐1‐yl)phenyl)‐1‐(2‐hydroxyphenyl)prop‐2‐en‐1‐ones in ethanol and hydrazine hydrate under reflux condition. The synthesized compounds were screened for antibacterial activity against Gram‐positive bacteria viz Staphylococcus aureus and Bacillus subtilis and Gram‐negative bacteria viz Escherichia coli and Salmonella typhi , respectively. Some of the tested compounds showed significant antimicrobial activity. IR, 1 H NMR, mass spectral data, and elemental analysis elucidated the structures of all the newly synthesized compounds.
Achievements of NEDO Durability Projects on SOFC Stacks in the Light of Physicochemical Mechanisms (2019)

Abstract Achievements of NEDO durability projects on SOFC mode are summarized with a focus on the physicochemical mechanisms characterized by diffusion properties of cell components and chemical reactions of cell components with gaseous impurities. Ni sintering and depletion including impurity (P, B, S) effects have been examined in terms of the surface/interface energies of Ni/oxide cermet anodes. The conductivity degradation due to the transformation of the cubic YSZ electrolyte was found to be characterized in terms of two time constants for the reductive and the oxidative regions to be determined by the Y‐diffusivity and its enhancement on NiO internal reduction in YSZ, while observed gaps in conductivity degradation behavior between stacks and button cells were ascribed to differences in those physicochemical properties involved, namely cation diffusion and kinetics associated with NiO internal reduction. The cathode performance degradation due to sulfur poisoning exhibits a variety of dependences on the microstructure (dense or porous) of doped‐ceria interlayers, the thickness of YSZ electrolyte and the humidity in the anode atmosphere, suggesting effects of protons in the cathode vicinity and the SrO activity changes during fabrication the LSCF/GDC/YSZ multilayers. Some defect chemical considerations were made on how such defects are affected by fabrication processes.