gebhart/patrepeval huggingface dataset:
Human-Activity Analysis in Multimedia Data (2007)

Many important applications in multimedia revolve around the detection of humans and the interpretation of their behavior. These include surveillance and intrusion detection, video conferencing applications, assisted living applications, and automatic analysis of sports videos, broadcasts, and movies, to name just a few. Success in these tasks often requires the integration of various sensor or data modalities such as video, audio, motion, and accompanying text, and typically hinges on a host of machine-learning methodologies to handle the inherent variability and complexity of the ensuing features. The computational efficiency of the resulting algorithms is critical since the amount of data to be processed in multimedia applications is typically large, and in real-time systems, speed is of the essence. There have been several recent special issues dealing with the dection of humans and the analysis of their activity relying solely on video footage. In this special issue, we have tried to provide a platform to contributions that make use of a broader spectrum of multimedia information, complementing video with audio or text information as well as other types of sensor signals, whenever available. The first group of papers in the special issue addresses the joint use of audio and video data. The paper
Highly efficient high power single-mode fiber amplifier utilizing the distributed mode filtering bandgap rod fiber (2012)

We report on an ytterbium doped single mode distributed mode filtering rod fiber in an amplifier configuration delivering high average output power, up to 292 watts, using a mode-locked 30ps source at 1032nm with good power conversion efficiency. We study the modal stability of the output beam at high average output power levels and demonstrate a 44% power improvement before the threshold-like onset of mode instabilities by operating the rod fiber in a leaky waveguide regime. We investigate the guiding dynamics of the rod fiber and explain the improved performance by thermally induced refractive index profile change.
Theoretical Intrinsic Equivalent Magnetic Noise Evaluation for Magneto (Elasto) Electric Sensors Using Modulation Techniques (2013)

The equivalent magnetic noise of magnetostrictive-piezoelectric composite sensors, in the passive mode or when magnetic modulation techniques are used, has been investigated theoretically and compared with measurements. Several main noise sources and their contributions to the equivalent magnetic noise spectral density have been analyzed using the fluctuation-dissipation theorem and modeled via Nyquist's noise-expression in the linear and non-linear regime. These theoretical analyzes show that the mechanical loss, related to the interfriction of composites, appears as the dominant noise source for such magnetoelectric modulation techniques.
Accelerated Testing of SiC Power Devices (2020)

Power metal-oxide-semiconductor field-effect transistors (MOSFETs) experience conditions of high field during normal operation. During switching conditions, unexpected transient events may occur which force devices into avalanche or short circuit conditions. Moreover, silicon carbide devices typically experience higher fields in the gate oxide and drift regions than comparable Si devices due to channel and drift property differences. A summary of 4H-SiC MOSFET reliability and ruggedness test results are reported here. Reliability tests under high field conditions: positive-bias and negative-bias temperature instability (PBTI, NBTI) to examine threshold stability; time-dependent dielectric breakdown (TDDB) for gate oxide lifetime extrapolation; high-temperature reverse bias (HTRB); and HTRB testing under high neutron flux to determine terrestrial neutron single-event burnout (SEB) rates. High-power ruggedness evaluation is presented for SiC MOSFETs under forced avalanche conditions (unclamped inductive switching (UIS)) and under short-circuit operation to bound device safe operating areas. Overall results demonstrate the intrinsic reliability of SiC MOSFETs.
Cell‐selective intracellular delivery of a foreign enzyme to endothelium in vivo using vascular immunotargeting (2001)

Vascular immunotargeting, the administration of drugs conjugated with antibodies to endothelial surface antigens, has the potential for drug delivery to the endothelium. Our previous cell culture studies showed that biotinylated antibodies to PECAM-1 (a highly expressed endothelial surface antigen) coupled with streptavidin (SA, a cross-linking protein that facilitates anti-PECAM internalization and targeting) may provide a carrier for the intracellular delivery of therapeutic enzymes. This paper describes the PECAM-directed vascular immunotargeting of a reporter enzyme (beta-galactosidase, beta-Gal) in intact animals. Intravenous injection of [125I]SA-beta-Gal conjugated with either anti-PECAM or IgG led to a high 125I uptake in liver and spleen, yet beta-Gal activity in these organs rapidly declined to the background levels, suggesting rapid degradation of the conjugates. In contrast, anti-PECAM/[125I]SA-beta-Gal, but not IgG/[125I]SA-beta-Gal, accumulated in the lungs (36.0+/-1.3 vs. 3.9+/-0.6% injected dose/g) and induced a marked elevation of beta-Gal activity in the lung tissue persisting for up to 8 h after injection (10-fold elevation 4 h postinjection). Using histochemical detection, the beta-Gal activity in the lungs was detected in the endothelial cells of capillaries and large vessels. The anti-PECAM carrier also provided 125I uptake and beta-Gal activity in the renal glomeruli. Predominant intracellular localization of anti-PECAM/SA-beta-Gal was documented in the PECAM-expressing cells in culture by confocal microscopy and in the pulmonary endothelium by electron microscopy. Therefore, vascular immunotargeting is a feasible strategy for cell-selective, intracellular delivery of an active foreign enzyme to endothelial cells in vivo, and thus may be potentially useful for the treatment of acute pulmonary or vascular diseases.
Intravenous administration of mesenchymal stem cells exerts therapeutic effects on parkinsonian model of rats: Focusing on neuroprotective effects of stromal cell-derived factor-1α (2010)

Consequently, MSC transplantation might exert neuroprotection on 6-OHDA-exposed dopaminergic neurons at least partly through anti-apoptotic effects of SDF-1alpha. The results demonstrate the potentials of intravenous MSC administration for clinical applications, although further explorations are required.
Compressed domain stitching of HEVC streams for video conferencing applications (2012)

We present a method for compressed domain stitching of streams coded according to the (draft) High Efficiency Video Coding (HEVC) specification for video conferencing applications. The main challenges for mixing of video streams in the compressed domain are elaborated and divided into pixel processing level, the level of syntax elements, and entropy coding level. A special focus is on the mechanisms of intra- and inter-prediction mismatch and the respective countermeasures. We propose a solution for mixing video streams on tile level enabling light-weight video stitching. This includes a novel approach for avoiding mismatch due to temporal prediction. The simulation results show a significant gain in compression efficiency and computational complexity over pixel domain stitching of video content.
Role of natural killer cell function in dendritic cell-based vaccines (2006)

Recent studies have elucidated the functional links between natural killer (NK) cells and, demonstrating the reciprocal activation of these cell types through NK-DC interactions. The subsets of cells and molecular pathways involved in such interactions have been defined, and the possible anatomical sites of these interactions have also been reported. Murine experiments have demonstrated that injection of mature DCs induces rapid recruitment of NK cells to lymph nodes and that these NK cells provide interferon-gamma for Type 1 priming. Thus, there is an increasing body of in vivo evidence indicating that NK-DC interactions during the early phase of innate immunity can impact the quality and magnitude of the subsequent adaptive immune response. Importantly, these studies imply that NK cells might not serve merely as cytotoxic lymphocytes combating viral pathogens and malignant tumors, but must also be considered as important immunoregulatory cells with a significant influence on adaptive immunity. In contrast to the large volume of knowledge obtained through basic research, there is a relative paucity of information regarding NK cell function in adaptive immunity from clinical trials, as few DC vaccine studies have attempted to evaluate the nonspecific, yet potentially clinically relevant, NK response to immunization. In this article, the authors will review studies focusing on NK-DC interactions and highlight the most recent clinical findings relating to the potential role of NK cells in DC-based vaccine therapy.
Supplementary Table from Tilsotolimod with Ipilimumab Drives Tumor Responses in Anti–PD-1 Refractory Melanoma (2023)

Supplementary Table from Tilsotolimod with Ipilimumab Drives Tumor Responses in Anti–PD-1 Refractory Melanoma
Implementing Multi-Agent Systems: Languages, Frameworks, and Standards (1998)

As multi-agent systems research nears the end of its second decade, researchers have moved beyond stand-alone, one-off systems and have begun to create the software infrastructure for quickly creating new, highly interoperable systems. However, the desire for seamless interoperability ("open" systems) brings with it the push to standardize on agent communication languages and related agent service facilities. Although a host of theoretical and practical controversies surround the specification of such standards, some shared, guiding principles have emerged.
Molecular cloning and nucleotide sequence of a cDNA clone coding for the cell attachment domain in human fibronectin. (1983)

A cDNA clone coding for the cell attachment domain in human fibronectin has been isolated using synthetic oligonucleotides. Three sets of mixed tetradecamer oligonucleotides were synthesized based on amino acid sequences in the 108-amino acid cell attachment domain (Pierschbacher, M. D., Ruoslahti, E., Sundelin, J., Lind, P., and Peterson, P. A. (1982) J. Biol. Chem. 257, 9593-9597). One of these sets was made complementary to amino acids located near the COOH terminus of the cell attachment domain and synthesized as a mixture of 24 sequences. This oligonucleotide mixture was used to prime cDNA synthesis with mRNA prepared from a human fibrosarcoma as a template. A cDNA library was constructed with the oligonucleotide-primed sequences in the vector pBR322. Colonies that hybridized with the primer were isolated from the library and further identified by hybridization with oligonucleotides deduced from an amino acid sequence located 45 amino acid residues NH2-terminal of the primer sequence. One clone which hybridized to both probes was characterized in detail. The insert was 380 base pairs long and its nucleotide sequence agreed completely with the corresponding amino acid sequence of human plasma fibronectin, showing that the sequences for this region are identical in plasma fibronectin and fibronectin from a cell line. This clone should be useful for studies on the expression of fibronectins and may also allow for the production of the biologically active cell attachment domain of fibronectin in bacteria.
Clinically Integrated Sequencing Alters Therapy in Children and Young Adults With High-Risk Glial Brain Tumors (2018)

Selection of personalized agents for children and young adults with highrisk brain tumors on the basis of integrative clinical sequencing is feasible and resulted in a change in therapy in more than two thirds of children and young adults with high-risk glial tumors.
A distributed routing protocol for predictable rates in wireless mesh networksy (2012)

Wireless mesh networks hold the promise of rapid and flexible deployments of communication facilities. This potential notwithstanding, the often erratic behavior of multihop wireless transmissions is limiting the range of applications that such networks can target. In this paper we investigate the feasibility and benefits of a routing protocol explicitly aimed at making wireless mesh networks more predictable while preserving their efficiency and flexibility. The protocol's basic premise is the classical idea that a multipath solution can offer resiliency to unexpected link variations. The paper's contributions are in demonstrating how this can be effectively realized in a wireless context, and in offering initial evidences of its efficacy. In particular, the paper illustrates how routing decisions that account for link variability can be computed in a distributed fashion, and the benefits they afford in improving the stability of end-to-end transmission rates even in the presence of random network fluctuations.
An explanation-based-learning approach to knowledge compilation: a Pilot's Associate application (1992)

The use of explanation-based learning as part of a larger knowledge compilation system for automating the development and maintenance of associate knowledge bases is discussed. Specifically, the implemented systems of the Learning Systems for Pilot Aiding (LSPA), which automates portions of the offline process of incorporating new information into the knowledge bases of Pilot's Associate, one of the largest and most thoroughly developed associate systems, and then propagates pertinent changes to other Pilot's Associate modules, are described. The learning algorithm and some modifications to it are also described. It is shown that the general approach should be relevant and easily generalizable to other intelligent associate systems, such as a submarine commander's associate and a helicopter pilot's associate. For substantially different systems, explanation-based learning should be generally valid as a front end for knowledge compilation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Forty years of landmark trials undertaken by the Danish Breast Cancer Cooperative Group (DBCG) nationwide or in international collaboration (2017)

The trials conducted and implemented by the DBCG appear to have a major impact on the substantial survival improvements in breast cancer.
A Short Synthesis of γ-Lycorane using Ni/AcOH Mediated Radical Cyclisation (1999)

A short synthesis of (±)-γ-lycorane 6 is described using two different radical cyclisations. The key step is the formation of tetrahydroindolone 9 by a nickel-promoted 5-endo radical cyclisation. This is followed by a tributylstannane-mediated 6-endo ring closure to the tetracyclic lactam 10 which is readily reduced to (±)-γ-lycorane 6.
DDRE-07. FATTY ACID SYNTHESIS IS REQUIRED FOR BREAST CANCER BRAIN METASTASIS (2021)

Abstract Brain metastases are refractory to therapies that otherwise control systemic disease in patients with human epidermal growth factor receptor 2 (HER2+) breast cancer, and the unique brain microenvironment contributes to this therapy resistance. Nutrient availability can vary across tissues, therefore metabolic adaptations required for breast cancer growth in the brain microenvironment may also introduce liabilities that can be exploited for therapy. Here, we assessed how metabolism differs between breast tumors growing in the brain versus extracranial sites and found that fatty acid synthesis is elevated in breast tumors growing in the brain. We determine that this phenotype is an adaptation to decreased lipid availability in the brain relative to other tissues, which results in a site-specific dependency on fatty acid synthesis for breast tumors growing at this site. Genetic or pharmacological inhibition of fatty acid synthase (FASN) reduces HER2+ breast tumor growth in the brain, demonstrating that differences in nutrient availability across metastatic sites can result in targetable metabolic dependencies.
Energy-efficient coordinated beamforming with rate dependent processing power (2016)

This paper studies energy-efficient coordinated beamforming in multi-cell multi-user multiple-input single-output (MISO) system. On contrary to the existing approaches where the power consumption of a base station is modeled as a convex or linear function, we consider a more practical model where part of the processing power depends on the rate provided by the base stations. Two optimization criteria are considered, namely network energy efficiency maximization and weighted sum energy efficiency maximization. We develop successive convex approximation based algorithms to tackle these difficult nonconvex problems. The numerical results illustrate that the rate dependent power consumption has a large impact on the energy efficiency, and, thus, has to be taken into account when devising energy-efficient transmission strategies.
Exploiting CMOS Manufacturing to Reduce Tuning Requirements for Resonant Optical Devices (2011)

We present manufacturing tolerances of cascaded silicon microring resonators fabricated in a commercial 130-nm complementary-oxide semiconductor (CMOS) foundry using 193-nm lithography and provide statistics gathered from over 500 four-channel microring arrays over multiple wafers and fabrication lots. We quantify intrawafer and interwafer variation of the position and relative spacing of resonance wavelengths for the microring arrays and confirm prior predictions that the absolute resonance positions of such devices cannot be controlled across wafers or even across reticles within a wafer. However, we show that the free spectral range (FSR) of the microrings can be controlled to within 0.66 nm (83 GHz) across wafers and lots, as can the wavelength spacing between closely spaced microrings. To exploit these findings for low-power optical interconnects, we suggest and demonstrate a synthetic resonant comb with FSR ≈ N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">*</sub> δλ, wherein resonance wavelengths are spaced equally across the FSR in order to minimize postfabrication tuning. The experimental CMOS 1 × 8 microring array requires an average tuning of less than 1.2 nm/channel to align to a 200-GHz wavelength division multiplexing (WDM) grid. Monte Carlo simulations on 100 000 sample runs show that an average tuning of 1.72 nm/channel is sufficient for 99% coverage for this component. This indicates that it is possible, with high statistical confidence, to use high-volume CMOS manufacturing to reduce the tuning range and tuning energy requirements of silicon microrings and, hence, enhance their ability to be used in high-density, energy-efficient computing system applications.
Comparison of clinical and angiographic prognostic risk scores in elderly patients presenting with acute coronary syndrome and referred for percutaneous coronary intervention (2015)

In elderly patients presenting with ACS and referred to PCI within 24 hours of admission, the GRACE score, the EuroSCORE, the AMIS score, and the SYNTAX score predicted 30 day mortality. The predictive value of clinical scores was improved by using them in combination.
Effects of HIV and Early Life Stress on Amygdala Morphometry and Neurocognitive Function (2012)

Abstract Both HIV infection and high levels of early life stress (ELS) have been related to abnormalities in frontal-subcortical structures, yet the combined effects of HIV and ELS on brain structure and function have not been previously investigated. In this study we assessed 49 non-demented HIV-seropositive (HIV+) and 47 age-matched HIV-seronegative healthy control (HC) adults. Levels of ELS exposure were quantified and used to define four HIV-ELS groups: HC Low-ELS ( N = 20); HC High-ELS ( N = 27); HIV+ Low-ELS ( N = 24); HIV+ High-ELS ( N = 25). An automated segmentation tool measured volumes of brain structures known to show HIV-related or ELS-related effects; a brief neurocognitive battery was administered. A significant HIV-ELS interaction was observed for amygdala volumes, which was driven by enlargements in HIV+ High-ELS participants. The HIV+ High-ELS group also demonstrated significant reductions in psychomotor/processing speed compared with HC Low-ELS. Regression analyses in the HIV+ group revealed that amygdala enlargements were associated with higher ELS, lower nadir CD4 counts, and reduced psychomotor/processing speed. Our results suggest that HIV infection and high ELS interact to increase amygdala volume, which is associated with neurocognitive dysfunction in HIV+ patients. These findings highlight the lasting neuropathological influence of ELS and suggest that high ELS may be a significant risk factor for neurocognitive impairment in HIV-infected individuals. ( JINS , 2012, 19 , 1–12)
Control of domain structure and magnetization reversal in thick Co/Pt multilayers (2019)

We present a study of the magnetic properties of ${[\mathrm{Co}(3.0\phantom{\rule{0.16em}{0ex}}\mathrm{nm})/\mathrm{Pt}(0.6\phantom{\rule{0.16em}{0ex}}\mathrm{nm})]}_{N}$ multilayers as a function of Co/Pt bilayer repetitions N. Magnetometry investigation reveals that samples with $N\ensuremath{\ge}15$ exhibit two characteristic magnetization reversal mechanisms, giving rise to two different morphologies of the remanent domain pattern. For applied magnetic field angles near the in-plane field orientation, the magnetization reversal proceeds via a spontaneous instability of the uniform magnetic state resulting in perpendicular stripe domains. Conversely, for field angles close to the out-of-plane orientation, the reversal occurs via domain nucleation and propagation leading to a mazelike domain pattern at remanence. Our measurements further enable the characterization of the N-dependent energy balance between the magnetic anisotropy and magnetostatic energy contributions, revealing a gradual disappearance of the domain nucleation process during magnetization reversal for N 14. This leads to the exclusive occurrence of an instability reversal mechanism for all field orientations as well as alignedlike stripe domains at remanence. Furthermore, a detailed study of the influence of the magnetic history allows the determination of a range of material properties and magnetic field strengths, where a lattice of bubble domains with remarkably high density is stabilized. These modulations of the ferromagnetic order parameter are found to strongly depend on N, in terms of center-to-center bubble distance as well as of bubble diameter. Moreover, such Co/Pt multilayers could be utilized to engineer field reconfigurable bubble domain lattices, which resemble magnonic crystals.