gebhart/patrepeval huggingface dataset:
A study of genetic diversity among Brassica napus and Brassica juncea germplasm collections using simple sequence repeat (SSR) molecular markers. (2003)

Brassica species represent a broad range of crops. This reflects the high degree of genetic diversity and related phenotypic plasticity. An understanding of the genetic basis of Brassica diversity aids both breeding and the discovery of rare alleles and traits. Simple sequence repeat (SSR) molecular markers are popular tools for assessing genetic diversity due to their high degree of polymorphism and their transferability across related species. We have applied public SSR markers to genotype international germplasm collections of B. napus and B. juncea as well as commercial Brassica lines grown in Australia. Results illustrate the genetic relationship between these lines and also provide a measure of the level of genetic uniformity within lines.
AI at the Edge, 2021 EPoSS White Paper (2021)

In this paper members of the European Platform on Smart Systems Integration (EPoSS) have collected their views on the benefits of incorporating Artificial Intelligence in future Smart devices and defined the actions required to achieve this to implement "AI at the Edge".
Handbook of Plastic Embedding (1970)

The middle and latter thirds of the book comprise a detailed dictionary, occupying another 650 pages, of analytical data from Acepifylline to Yohimbine, with MP and Rf values, u-v maxima, i-v peaks and char- acteristic spectra, reagent data-and a very full bibliography.It is a remarkable book: a vade mecum every analytical chemist and toxicologist must have at his elbow.It is, indeed, the only really full and authoritative guide in this difficult field, of equal importance to both clinical and postmortem toxicologists.The price is immaterial.
Opportunities for Biorenewables in Petroleum Refineries (2006)

A presentation by UOP based on collaborative work from FY05 using some results from PNNL for upgrading biomass pyrolysis oil to petroleum refinery feedstock
Antifolate-resistant Chinese hamster cells. Evidence for dihydrofolate reductase gene amplification among independently derived sublines overproducing different dihydrofolate reductases. (1980)

Purification of a cDNA probe specific for dihydrofolate reductase mRNA has allowed the relative quantification of dihydrofolate reductase gene numbers and mRNA levels between a line of Chinese hamster lung fibroblasts sensitive to the antifolate drugs methotrexate and methasquin and sublines which by virtue of their overproduction of the target enzyme dihydrofolate reductase are cross-resistant to these site-specific inhibitors. Previous results have shown that resistant sublines could overproduce one of two molecular weight forms of dihydrofolate reductase, one parental-like (Mr = 21,000) and one nonparental-like (Mr = 20,000), each encoded by a different mRNA present in elevated amounts in resistant cells (Melera, P. W., Wolgemuth, D., Biedler, J. L., and Hession, C. (1980). J. Biol. Chem. 255, 319--322). The cDNA-RNA and cDNA-DNA hybridization experiments reported here confirm the elevated levels of dihydrofolate reductase-specific mRNA in resistant cells and show that the overproduction of either molecular weight form of dihydrofolate reductase is accompanied by amplification in dihydrofolate reductase gene number.
Identification of toxic alkaloids from the calcaratus subspecies of Lupinus arbustus (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIdentification of toxic alkaloids from the calcaratus subspecies of Lupinus arbustusGeorge M. Hatfield, David J. Yang, Paul W. Ferguson, and William J. KellerCite this: J. Agric. Food Chem. 1985, 33, 5, 909–912Publication Date (Print):September 1, 1985Publication History Published online1 May 2002Published inissue 1 September 1985https://pubs.acs.org/doi/10.1021/jf00065a034https://doi.org/10.1021/jf00065a034research-articleACS PublicationsRequest reuse permissionsArticle Views61Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Polymerization of Ionized Acetylene Clusters into Covalent Bonded Ions:  Evidence for the Formation of Benzene Radical Cation (2006)

Since the discovery of acetylene and benzene in protoplanetary nebulae under powerful ultraviolet ionizing radiation, efforts have been made to investigate the polymerization of ionized acetylene. Here we report the efficient formation of benzene ions within gas-phase ionized acetylene clusters (C2H2)n+ with n = 3-60. The results from experiments, which use mass-selected ion mobility techniques, indicate that the (C2H2)3+ ion has unusual stability similar to that of the benzene cation; its primary fragment ions are similar to those reported from the benzene cation, and it has a collision cross section of 47.4 A2 in helium at 300 K, similar to the value of 47.9 A2 reported for the benzene cation. In other words, (C2H2)3+ structurally looks like benzene, it has stability similar to that of benzene, it fragments such as benzene, therefore, it must be benzene!
Primary reconstruction for spinal infections (1997)

Primary reconstruction using bone grafts and instrumentation for spinal infections remains controversial. Between 1991 and 1993, 27 infections of the spinal column were treated at the Department of Neurosurgery of the University of Florida. Of the 27 cases 20 (six cervical, eight thoracic, and six lumbar spine) required surgical debridement and spinal reconstruction to maximize eradication of the infection and maintenance of spinal alignment. All of the cervical and lumbar cases were caused by bacterial infections, and two of eight thoracic cases were caused by tuberculous infections. Spinal arthrodesis was performed in all cases: interbody grafts were used in 18 procedures and posterolateral onlay grafts in 14. Interbody grafts were autologous in 10 cases (six rib and four iliac crest) and homoplastic in eight (six fibular and two humerus). All of the posterolateral onlay grafts were autologous (three rib and 11 iliac crest). Spinal instrumentation was used in 15 cases: four with Caspar plates and 11 with posterior segmental fixation (five hook/rod constructs and six screw/rod constructs). Seventeen of 20 patients achieved improved clinical status postoperatively and 18 of 20 showed radiographic evidence of bone fusion. Antibiotic drugs were administered parenterally for an average of 6 weeks followed by a 3-month course of oral antibiotic medications. Tuberculous infections were treated for 1 year with antibiotic therapy. The average follow-up period was 37 months from surgery and 31 months after completion of treatment with antibiotic drugs. The authors conclude that primary arthrodesis and instrumentation can be performed in acute spinal infections; however, successful management depends on aggressive debridement of infectious foci and prolonged treatment with parenteral antibiotic drugs.
Electrical Biomolecule Detection Using Nanopatterned Silicon via Block Copolymer Lithography (2013)

An electrical biosensor exploiting a nanostructured semiconductor is a promising technology for the highly sensitive, label-free detection of biomolecules via a straightforward electronic signal. The facile and scalable production of a nanopatterned electrical silicon biosensor by block copolymer (BCP) nano-lithography is reported. A cost-effective and large-area nanofabrication, based on BCP self-assembly and single-step dry etching, is developed for the hexagonal nanohole patterning of thin silicon films. The resultant nanopatterned electrical channel modified with biotin molecules successfully detects the two proteins, streptavidin and avidin, down to nanoscale molarities (≈1 nm). The nanoscale pattern comparable to the Debye screening length and the large surface area of the three-dimensional silicon nanochannel enable excellent sensitivity and stability. A device simulation confirms that the nanopatterned structure used in this work is effective for biomolecule detection. This approach relying on the scalable self-assembly principle offers a high-throughput manufacturing process for clinical lab-on-a-chip diagnoses and relevant biomolecular studies.
Supplementary Table S5 from Integrating RAS Status into Prognostic Signatures for Adenocarcinomas of the Lung (2023)

&lt;p&gt;Supplementary Table S5. Complete list of Entrez GeneIDs and Gene Symbols for all signatures.&lt;/p&gt;
Phosphorylation of CREB at Ser-133 Induces Complex Formation with CREB-Binding Protein via a Direct Mechanism (1996)

We have characterized a phosphoserine binding domain in the coactivator CREB-binding protein (CBP) which interacts with the protein kinase A-phosphorylated, and hence activated, form of the cyclic AMP-responsive factor CREB. The CREB binding domain, referred to as KIX, is alpha helical and binds to an unstructured kinase-inducible domain in CREB following phosphorylation of CREB at Ser-133. Phospho-Ser-133 forms direct contacts with residues in KIX, and these contacts are further stabilized by hydrophobic residues in the kinase-inducible domain which flank phospho-Ser-133. Like the src homology 2 (SH2) domains which bind phosphotyrosine-containing peptides, phosphoserine 133 appears to coordinate with a single arginine residue (Arg-600) in KIX which is conserved in the CBP-related protein P300. Since mutagenesis of Arg-600 to Gln severely reduces CREB-CBP complex formation, our results demonstrate that, as in the case of tyrosine kinase pathways, signal transduction through serine/threonine kinase pathways may also require protein interaction motifs which are capable of recognizing phosphorylated amino acids.
Preparation of Negamycin Ointments. I (1986)

To prepare the ointment of antibiotic negamycin (NGM), the release behavior from various ointment bases, antimicrobial activity, and chemical stability of NGM were investigated. In vitro release of NGM from gel base was greater than that from hydrophilic ointment JPX and white petrolatum containing 5 w/w% liquid paraffin. The release rate and the amount of NGM released from the gel base were found to increase in proportion to the content of Hiviswako No.104 in the ointment. NGM was much more stable in gel base than in hydrophilic ointment JPX, though it was decomposed under pseudo-first-order kinetics in both ointment bases. Antimicrobial activity of NGM ointment was evaluated by the cup-plate method, suggesting a sufficient efficacy of NGM for the treatment of infectious diseases caused by gram-positive or gram-negative bacterium. The present data suggest the possible utility of gel base in preparation of NGM ointment.
Cisvariants identified in F508del complex alleles modulate CFTR channel rescue by small molecules (2017)

Molecules correcting the trafficking (correctors) and gating defects (potentiators) of the cystic fibrosis causing mutation c.1521_1523delCTT (p.Phe508del) begin to be a useful treatment for CF patients bearing p.Phe508del. This mutation has been identified in different genetic contexts, alone or in combination with variants in cis. Until now, 21 exonic variants in cis of p.Phe508del have been identified, albeit at a low frequency. The aim of this study was to evaluate their impact on the efficacy of CFTR-directed corrector/potentiator therapy (Orkambi). The analysis by minigene showed that two out of 15 cis variants tested increased exon skipping (c.609C > T and c.2770G > A). Four cis variants were studied functionally in the absence of p.Phe508del, one of which was found to be deleterious for protein maturation c.1399C > T (p.Leu467Phe). In the presence of p.Phe508del, this variant was the only to prevent the response to Orkambi treatment. This study showed that some patients carrying p.Phe508del complex alleles are predicted to poorly respond to corrector/potentiator treatments. Our results underline the importance to validate treatment efficacy in the context of complex alleles.
c-Abl Inhibitors Enable Insights into the Pathophysiology and Neuroprotection in Parkinson’s Disease (2016)

Parkinson's disease (PD) is a progressive neurodegenerative disorder causing movement disabilities and several non-motor symptoms in afflicted patients. Recent studies in animal models of PD and analyses of brain specimen from PD patients revealed an increase in the level and activity of the non-receptor tyrosine kinase Abelson (c-Abl) in dopaminergic neurons with phosphorylation of protein substrates, such as α-synuclein and the E3 ubiquitin ligase, Parkin. Most significantly inhibition of c-Abl kinase activity by small molecular compounds used in the clinic to treat human leukemia have shown promising neuroprotective effects in cell and animal models of PD. This has raised hope that similar beneficial outcome may also be observed in the treatment of PD patients by using c-Abl inhibitors. Here we highlight the background for the current optimism, reviewing c-Abl and its relationship to pathophysiological pathways prevailing in PD, as well as discussing issues related to the pharmacology and safety of current c-Abl inhibitors. Clearly more rigorously controlled and well-designed trials are needed before the c-Abl inhibitors can be used in the neuroclinic to possibly benefit an increasing number of PD patients.
Sinus Node Region as an Ultimate Source Driving Chronic Atrial Fibrillation (2005)

A 39-year-old male was referred to our institution for catheter ablation of chronic atrial fibrillation (AF) with worsening dyspnea. AF was first diagnosed 25 years ago concomitant to an episode of myocarditis. He had failed treatment using antiarrhythmics, multiple cardioversions, and maze procedure; with AF being permanent over the last 21 years. Electrophysiological study demonstrated no electrical activity in all pulmonary veins, the posterior left atrium (LA), a part of the anterior LA, and the posterior and the lateral right atrium (RA), presumably as a consequence of myocarditis, the maze procedure, and long-lasting AF. Catheter ablation started with a linear lesion between the postero-lateral mitral annulus and the left inferior pulmonary vein, and then targeted the regions with short cycle length and/or fractionated activity in the septum, the roof, and the inferior wall of the LA. This procedure resulted in nearly total abolition of LA activity except in the antero-septal wall and the coronary sinus. Then, mapping was performed in the RA and demonstrated shorter cycle length activity than in the LA. Disconnection of the superior vena cava and ablation of the cavotricuspid isthmus was performed without effect on the fibrillatory cycle length. Using two multielectrode catheters, mapping identified the activity with the shortest cycle length in the sinus node region. Radiofrequency ablation was performed from the anterior RA laterally to an electrically silent area in the posterior RA. After 15 minutes of radiofrequency energy delivery, AF terminated suddenly simultaneous with electrical isolation of the sinus node region (Fig. 1). The earliest atrial activity was mapped in the septal RA. Local firing with a cycle length of 210 msec persisted in the sinus node region continuously for >30 minutes after ablation. The estimated surface area of isolated region with persistent firing was 2 × 3 cm. The remaining RA was activated by septal automatic rhythm, which had occasional pauses relayed by an escape junctional rhythm. This atrial rhythm was maintained after the procedure with a mean of 50 beats/min; however, AF recurred 3 weeks later and remained persistent. This case demonstrated that fibrillatory sources can be localized in the sinus node region, thus implicating an extensive distribution of the critical substrate maintaining chronic AF.
Second-order rate-control based transport protocols (2005)

We propose an efficient flow and error control scheme for high-throughput transport protocols by using a second-order rate control, called the /spl alpha/-control, and a new sliding-window scheme for error control. The /spl alpha/-control minimizes the packet retransmissions by adjusting the rate-gain parameter to the variations in the number and round-trip times (RTTs) of cross-traffic flows that share the bottleneck. Using selective retransmission, the sliding-window scheme guarantees lossless transmission. By applying the /spl alpha/-control, the proposed scheme can drive the flow-controlled system to a retransmission-less equilibrium state. Using the fluid analysis, we establish the flow-control system model, obtain the greatest lower bound for the target buffer occupancy, and derive closed-form expressions for packet losses, loss rate, and link-transmission efficiency. We prove that the /spl alpha/-control is feasible and optimal linear control in terms of efficiency and fairness. Also presented are the extensive simulation results that confirm the analytical results, and demonstrate the superiority of the proposed scheme to others in dealing with the variations of cross-traffic flows sharing the same bottleneck and their RTTs, controlling packet losses/retransmissions, and achieving buffer-usage fairness as well as high throughput.
System performance evaluation in terrestrial systems with high polarization mode dispersion and the effect of chirping (2001)

We evaluate the system power penalty for different modulation formats-nonreturn-to-zero (NRZ), return-to-zero (RZ), dispersion-managed solitons, and prechirped RZ-in the presence of polarization mode dispersion (PMD) for 10-Gb/s terrestrial systems. All orders of PMD are considered by simulating the fiber using the coarse-step method, and a statistical approach is used to estimate the occasional fading of the signals. We show that pulses with lower duty-cycles perform better in general, and the system performance is improved if appropriate prechirping interacts with the residual chromatic dispersion of the fiber.
Monte Carlo convergence of rival samplers (2013)

It is often necessary to make sampling-based statistical inference about many probability distributions in parallel. Given a finite computational resource, this article addresses how to optimally divide sampling effort between the samplers of the different distributions. Formally approaching this decision problem requires both the specification of an error criterion to assess how well each group of samples represent their underlying distribution, and a loss function to combine the errors into an overall performance score. For the first part, a new Monte Carlo divergence error criterion based on Jensen-Shannon divergence is proposed. Using results from information theory, approximations are derived for estimating this criterion for each target based on a single run, enabling adaptive sample size choices to be made during sampling.
Photonic integrated circuits for nanoscopy (2018)

Photonic chips have the potential to cause a paradigm shift in super-resolution optical microscopy. Here we discuss geometry optimization of high refractive index waveguides for bioimaging and the implementation of super-resolution methods.
A 0.5-4GHz Programmable-Bandwidth Fractional-N PLL for Multi-protocol SERDES in 28nm CMOS (2016)

A 0.5-4GHz fractional-N phase locked loop (PLL) capable of spread-spectrum clock (SSC) generation in low leakage 28nm CMOS process is presented. A novel technique of bandwidth control enables the PLL to be used for clocking multi-protocol SERDES PHYs. The PLL has a voltage controlled ring oscillator and achieves a phase noise of-86dBc/Hz at 1MHz offset for 4GHz operation. It supports an input frequency range of 10MHz to 100MHz, occupies an area of 0.092mm2 and consumes 9.56mW power.
A Simple Magnetic Charge Model for Classification of Multiple Buried Metallic Objects in Cases with Overlapping Signals (2005)

This paper presents an application of a simple surface magnetic charge model to discriminate between objects of interest such as unexploded ordnance (UXO) and innocuous items, in cases when signals from buried objects are a mixture of responses from two or more items. In the low frequency (ten's of Hertz up to several hundred's of kHz) electromagnetic induction (EMI) sensing considered here, both conduction and displacement currents may be neglected within the medium surrounding a metallic object. Therefore, the scattered magnetic field outside the object is represented in terms of scalar potential fields, from which one can obtain all scattered magnetic fields. While these are time dependent by virtue of forcing functions or boundary conditions, they correspond in structure to static fields. Such fields are appropriately, and readily, produced mathematically by equivalent elementary magnetic charges placed on a convenient fictitious closed surface [1, 2, 3]. This forward model is physically complete in the sense that all heterogeneity, near and far field, and internal interaction effects within the object are included. It is very fast; in particular it can be implemented in inversion calculations on a PC. According to the Gauss's law, , the net flux of magnetic field through any closed surface equals the total (equivalent) magnetic charge inside the surface. The frequency spectrum of this total induced equivalent charge is used here as a discriminant. Based on measured data from two scatterers together, an iterative two step procedure is used in conjunction with the differential evolution (DE) algorithm [4, 5]. One step determines of each object's location and orientation and the other determines the amplitudes of the responding fictitious magnetic charges. Once the objects are isolated, the total magnetic charge for each is calculated as a function of frequency and compared to cataloged/library data. Finally, blind classification analyses are performed for a single object as well as for multiple subsurface scatterers, when two objects appear simultaneously within the field of view of the sensor.