gebhart/patrepeval huggingface dataset:
Combinatorial Chemistry And Technologies : Methods And Applications (2018)

Automation in Combinatorial Chemistry. Computational Aspects of Combinatorial Chemistry. High Throughput Combinatorial Methods for Heterogeneous Catalysts Design and Development. Biological Libraries. Peptide Display Libraries: Design and Construction. Making and Selecting from Phage Antibody Libraries. Biopanning. Oligonucleotide Library Preparation and Screening. Application of Selex Technology to Drug and Diagnostic Development. Combinatorial Proteomic. A Combinatorial Approach to Gene Expression Analysis: DNA Microarrays. Economics of Combinatorial Chemistry and Combinatorial Technologies.
Solid state and solution structural investigation of homoleptic tin(IV) alkoxide compounds. Part I. Sn(O—t-Bu)4 and [Sn(O—i-Pr)4•HO—i-Pr]2 (1991)

The crystal and molecular structures of Sn(O—t-Bu) 4 • and [Sn(O—i-Pr) 4 •HO—i-Pr] 2 have been determined by single-crystal X-ray diffraction. Sn(O—t-Bu) 4 crystallizes in the monoclinic crystal system with space group C2/c, where a = 17.382(6) Å, b = 8.742(2) Å, c = 15.518(5) Å, β = 116.44(1)°, Z = 4, and R = 2.5%. Sn(O—t-Bu) 4 is monomeric in the solid state, with a distorted tetrahedral tin coordination environment. [Sn(O—i-Pr) 4 •HO—i-Pr] 2 crystallizes in the monoclinic crystal system with space group P2 1 /n, where a = 11.808(3) Å, b = 14.356(3) Å, c = 12.380(2) Å, β = 95.27(2)°, Z = 2, and R = 4.9%. [Sn(O—i-Pr) 4 •HO—i-Pr] 2 exhibits an edge-shared, bi-octahedral structure in the solid state that is distorted due to the presence of asymmetric hydrogen bonding between axially coordinated alcohol ligands and an isopropoxide ligand. 13 C NMR and IR spectroscopic data have been recorded for Sn(O—t-Bu) 4 and Sn(O—t-Bu-d 9 ) 4 to establish criteria for unambiguous identification of solution structures of tin(IV) alkoxides. It is demonstrated that the two-bond [Formula: see text] coupling constant is larger for terminal alkoxide ligands than for μ 2 -alkoxide bridges, and the ν(Sn—O) stretching frequency has been assigned. The dynamic solution behaviour of [Sn(O—i-Pr) 4 •HO—i-Pr] 2 has been studied using variable temperature 1 H and 13 C NMR spectroscopy. The data obtained are consistent with a process that involves rapid reversible dissociation of isopropanol at room temperature. Upon cooling, the equilibrium concentration of the species with coordinated alcohol increases, and the molecule undergoes rapid intramolecular proton transfer (AG ≠ &lt; 11.9 kcalmol −1 ). Upon further cooling, the 13 C NMR data are consistent with a solution structure analogous to that found in the solid state. Key words: tin, alkoxide, NMR, dynamic, structure.
Supplementary Table S3 from A Very Long-acting Exatecan and Its Synergism with DNA Damage Response Inhibitors (2023)

&lt;p&gt;Synergy of PEG-Exa 3A and the ATRi VX-970.&lt;/p&gt;
An Instrumented Minimally Invasive Surgical Tool: Design and Calibration (2011)

Minimally invasive surgical procedures have improved the standard of patient care by reducing recovery time, chance of infection, and scarring. A recent review estimates that leaks occur in 3% to 6% of bowel anastomoses, resulting in “increased morbidity and mortality and adversely [affecting] length of stay, cost, and cancer recurrence” [23]. Many of these leaks are caused by poor handling and ischemic tissue.
Highly UV‐Sensitive and Responsive Benzothiophene/Dielectric Polymer Blend‐Based Organic Thin‐Film Phototransistor (2015)

It is reported on drain current modulation by UV light, in an organic thin‐film phototransistor, based on a small molecule semiconductor 2,7‐dipentylbenzo[b]benzo[4,5]thieno[2,3‐d]thiophene (BTBT‐C5) blended with a linear unsaturated polyester (L‐upe) to form the active channel material. The electrical properties of the phototransistor (L‐upe+BTBT‐C5) and physical properties of thin‐films are evaluated by means of two‐ and three‐terminal current–voltage characteristics (in the dark and under UV light) and structure–morphology analysis, respectively. Upon illumination with UV light, a dramatic change in the electrical properties of the L‐upe+BTBT‐C5 transistors is observed, compared to low responsive control transistors based on a blend of poly(methyl methacrylate) and BTBT‐C5. Drain current is increased by more than six orders of magnitude with maximum photosensitivity and responsivity of 4.0 × 10 6 and 11.1 A W −1 , respectively, using a V G = 0 V. Modulated photoelectrical properties are explained by structure–morphology characteristics and efficient charge trapping at the polymer/semiconductor interface due to the presence of electron‐withdrawing groups in the polymer. Fast rise time of 1.80 s and slow relaxation time of 24.27 s, estimated using bi‐exponential fitting models, confirm a charge trapping/releasing mechanism and reveal sensing‐memory properties of the devices.
ChemInform Abstract: A New Hydrazine‐Bridged Thioantimonate Mn2Sb4S8 (N2H4)2: Synthesis, Structure, Optical and Magnetic Properties. (2011)

Abstract The title compound is solvothermally synthesized from a mixture of Sb 2 S 3 , Mn, S, and hydrazine monohydrate (autoclave, 160 °C, 7 d, 70% yield).
Parvovirus B19 Is Inactivated by Pasteurization, a Dedicated Virus Inactivation Step in the Manufacturing Process of Plasma-Derived Products. (2009)

Abstract Abstract 3152 Poster Board III-89 Human parvovirus B19 (B19V), a small non-enveloped virus, is the causative agent of the childhood disease erythema infectiosum (fifth disease) but causes, especially when the disease occurs during adulthood, a number of clinical symptoms as arthralgia, arthritis, (transient) aplastic crisis, anaemia, and hydrops fetalis (during pregnancy). B19V is normally spread via the respiratory route, however, parenteral transmission can occur through blood or blood components and plasma-derived products. In order to demonstrate the safety of plasma-derived products regarding B19V, virus validation studies are performed, using usually animal parvoviruses as models for B19V which indicate that this virus is highly resistant to commonly used inactivation methods as heat. Employing a cell culture infectivity assay for B19V, established at CSL Behring's virology laboratory, a considerable higher sensitivity of B19V to pasteurization (heat treatment in aqueous solution at 60°C for 10 hours) could be demonstrated for B19V in contrast to the animal parvovirus CPV (canine parvovirus). B19V was not only very sensitive to heat in unstabilised product intermediates but also heat sensitive when studying intermediates of various plasma products containing high concentrations of the stabilizers sucrose and glycine. Although these protein stabilizers had also a stabilizing effect on B19V this virus was nevertheless considerably more sensitive to pasteurization than CPV. As shown below, pasteurization results in an effective inactivation of B19V in a wide range of plasma-derived products. Product Mean Virus Reduction Factor [log10] due to Pasteurization B19V CPV VWF / FVIII (Humate-P) ≥3.9 1.1 FVIII (Beriate P) a ≥3.8 0.7 Fibrinogen (RiaSTAP) b ≥4.5 1.6 PCC (Beriplex P/N) a 3.5 0.5 C1-INH (Berinert P) a 3.9 1.4 Human Thrombin a 3.5 0.5 FXIII (Fibrogammin P) a ≥4.0 1.0 scIG (Vivaglobin) ≥5.0c 2.3 Human albumin (different products) ≥4.3 1.6 a product not licensed in USA b Pasteurization time 20 hours c studied in a porcine immunoglobulin intermediate to avoid neutralization by human IgG Based on these experimental data on inactivation of B19V by pasteurization and a plasma pool for fractionation not exceeding 104 IU B19V DNA/ml, the virus safety of plasma-derived products regarding B19V can be assessed more correctly demonstrating an appropriate margin of safety. Disclosures Groener: CSL Behring: Employment. Nowak:CSL Behring: Employment. Schäfer:CSL Behring: Employment.
Analog ESD Circuits (2014)

This chapter provides examples of ESD devices used in analog semiconductor chip design. The ESD device examples include both low-voltage and high-voltage ESD networks from diodes, MOSFETs, LDMOS, and DeMOS devices in parallel and series configurations. The chapter closes with examples of ultrahigh voltage (UHV) devices. In this chapter, the analog ESD design discipline will be introduced, applying both the ESD requirements and the layout concepts of analog circuitry. This will include the digital ESD design discipline, in contrast to the analog ESD design discipline.
Structural Diversity of Host—Guest and Intercalation Complexes of Fullerene C60 (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Electrode|electrolyte interface enhancement in quasi-solid-state zinc–air batteries through an anion conducting polymer electrolyte interlayer by in situ polymerization (2023)

This work introduces a novel concept of UV light-assisted in situ polymerization at the electrode|electrolyte interface in combination with an anion-conducting polymer electrolyte membrane (AEPEM) to improve the performance of quasi-solid-state ZABs.
Serum mesothelin and megakaryocyte potentiating factor in pancreatic and biliary cancers (2011)

Serum mesothelin and MPF concentrations, measured with standard available ELISAs, were not specific for benign or pancreatic disease. Both biomarkers were not elevated in patients with pancreatic or biliary cancers, and consequently do not appear to be useful biomarkers for these malignancies.
Exposure to caffeine and suppression of DNA replication combine to stabilize the proteins and RNA required for premature mitotic events (1987)

Caffeine had been shown to induce mitotic events in Syrian hamster fibroblast (BHK) cells that were arrested during DNA replication (Schlegel and Pardee, Science 232:1264-1266, 1986). Inhibition of protein synthesis blocked these caffeine-induced events, while inhibition of RNA synthesis showed little effect. We now report that the protein(s) that are required for inducing mitosis in these cells were synthesized shortly after caffeine addition, the activity was very labile in the absence of caffeine, and the activity was lost through an ATP-dependent mechanism. Caffeine dramatically increased the stability of these putative proteins while having no effect on overall protein degradation. Experiments with an inhibitor of RNA synthesis indicated that mitosis-related RNA had accumulated during the suppression of DNA replication, and this RNA was unstable when replication was allowed to resume. These results suggest that the stability of RNA needed for mitosis is regulated by the DNA replicative state of the cell and that caffeine selectively stabilizes the protein product(s) of this RNA. Conditions can therefore be selected that permit mitotic factors to accumulate in cells at inappropriate times in the cell cycle. Two-dimensional gel electrophoresis has demonstrated several protein changes resulting from caffeine treatment; their relevance to mitosis-inducing activity remains to be determined.
Modulation on C‐ and N‐Terminal Moieties of a Series of Potent and Selective Linear Tachykinin NK2 Receptor Antagonists (2009)

Herein we describe the synthesis of a series of new potent tachykinin NK(2) receptor antagonists by the modulation of the C- and N-terminal moieties of ibodutant (MEN 15596, 1). The N-terminal benzo[b]thiophene ring was replaced by different substituted naphthalenes and benzofurans, while further modifications were evaluated at the C-terminal tetrahydropyran moiety. Most compounds demonstrated a high affinity for the human NK(2) receptor and high in vitro antagonist potency, indicating that a wide range of substituents at both termini can be incorporated in the molecule without detrimental effects on the interactions with the NK(2) receptor. Selected compounds were tested in vivo confirming their activity as NK(2) antagonists. In particular, after both iv and id administration to guinea pig, compound 61 b was able to antagonize NK(2)-induced colonic contractions with a potency and duration-of-action fully comparable to the reference compound 1 (MEN 15596, ibodutant).
High-risk ACS patients and cardiac biomarkers in the emergency department: any role for new biomarkers of myocardial ischaemia? Reply (2007)

Roy et al. have raised an interesting question of the role of additional biomarkers like ischaemia-modulated albumin (IMA) for the early detection of myocyte injury in the setting of acute coronary syndrome. Indeed, many such markers including, unbound free fatty acids, glycogen phosphorylase isoenzyme BB and choline have been proposed for early detection of cardiac ischaemia.1 Everyone is interested in finding …
Fast crystal nucleation induced by surface oxidation in Si-doped GeTe amorphous thin film (2012)

Fast crystallization in the phase change materials (PCMs) used for optical and electrical phase change memory improves their data recording rate. In the present work, it was found that the preferential surface oxidation of Si shortens the nucleation time of Ge46.55Te46.55Si6.9 amorphous films. The nucleation time of a surface-oxidized film was approximately 20% faster than that of a non-oxidized film. This was due to the formation of inhomogeneous nucleation sites at the film surface. These results suggest that preferential surface oxidation of PCM is an effective method to enhance the data recording rate of phase change memory devices.
Supplementary Figure S5 from Direct Detection and Quantification of Neoantigens (2023)

&lt;p&gt;MS/MS analysis of the contamination.&lt;/p&gt;
Computer Quiz Games in General Chemistry for Engineering Majors in an English as a Second Language Environment (2021)

Computer quiz games are introduced to improve teaching and learning in a freshman engineering chemistry course in an English-as-a-Second-Language (ESL) environment. These quiz games are developed and implemented as a supplemental and augmentative tool to enhance traditionally delivered lectures. The paper shows an increase in students’ motivation and compare the performance between students who participated in computer quiz games, a paper-based quiz or neither activity. Assessment of the effectiveness of quiz games in learning is conducted via a proposed novel chemistry achievement test, Freshman Engineering Chemistry Aptitude Test and an attitude questionnaire. The findings contribute to our understanding of the role of game-based learning in students’ achievement in chemistry and their motivation and attitudes towards learning general chemistry at a university within an ESL environment, while the computer games developed are useful in all English based Chemistry classes.
ChemInform Abstract: Enantioselective Heterogeneous Synergistic Catalysis for Asymmetric Cascade Transformations. (2015)

Abstract A silica‐supported chiral amine and diaminopalladium complex is synthesized.
5,11-Dihydro-5,11-di-1-naphthylindolo[3,2-b]carbazole:  Atropisomerism in a Novel Hole-Transport Molecule for Organic Light-Emitting Diodes (1999)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXT5,11-Dihydro-5,11-di-1-naphthylindolo[3,2-b]carbazole: Atropisomerism in a Novel Hole-Transport Molecule for Organic Light-Emitting DiodesNan-Xing Hu, Shuang Xie, Zoran Popovic, Beng Ong, Ah-Mee Hor, and Suning WangView Author Information Xerox Research Center of Canada 2660 Speakman Drive Mississauga, Ontario, Canada L5K 2L1 Department of Chemistry, Queen's University Kingston, Ontario, Canada K7L 3N6 Cite this: J. Am. Chem. Soc. 1999, 121, 21, 5097–5098Publication Date (Web):May 14, 1999Publication History Received1 March 1999Published online14 May 1999Published inissue 1 June 1999https://pubs.acs.org/doi/10.1021/ja9906554https://doi.org/10.1021/ja9906554rapid-communicationACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views1970Altmetric-Citations118LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Amorphous materials,Diodes,Layers,Molecular structure,Molecules Get e-Alerts
Frank Partial Dislocation in 4H-SiC Epitaxial Layer by MSE Method (2012)

We have been trying to improve a quality of crystal, using the metastable solvent epitaxy (MSE) method, one of the solution methods. In MSE, a Frank-type fault is formed by conversion of a threading screw dislocation (TSD) in the substrate. To study the status of the growth, we performed plane-viewed TEM observation. Analysis of Burgers vectors in the TEM image showed Frank PDs (Partial Dislocations) which do not include a components and Frank PDs which include a components. The total Burgers vectors of Frank-type fault including a components are represented as b=a/3+c, which indicates some TSDs in the substrate also include a components.
Mobile VR on edge cloud (2019)

In this paper we design and implement MEC-VR, a mobile VR system that uses a Mobile Edge Cloud (MEC) to deliver high quality VR content to today's mobile devices using 4G/LTE cellular networks. Our main contribution is in realizing a low latency control loop that streams VR scenes containing only the user's Field of View (FoV) and a latency-adaptive margin area around the FoV. This allows the clients to render locally at a high refresh rate to accommodate and compensate for the head movements before the next motion update arrives. Compared with prior approaches, our MEC-VR design requires no viewpoint prediction, supports dynamic and live VR content, and adapts to the real-world latency experienced in cellular networks between the MEC and mobile devices. We implement a prototype of MEC-VR and evaluate its performance on a MEC node connected to an LTE testbed. We demonstrate that MEC-VR can effectively stream live VR content up to 8K resolution over 4G/LTE networks and achieve more than 80% of bandwidth savings.
Sensing Behavior of Atomically Thin-Layered MoS2 Transistors (2013)

Most of recent research on layered chalcogenides is understandably focused on single atomic layers. However, it is unclear if single-layer units are the most ideal structures for enhanced gas-solid interactions. To probe this issue further, we have prepared large-area MoS2 sheets ranging from single to multiple layers on 300 nm SiO2/Si substrates using the micromechanical exfoliation method. The thickness and layering of the sheets were identified by optical microscope, invoking recently reported specific optical color contrast, and further confirmed by AFM and Raman spectroscopy. The MoS2 transistors with different thicknesses were assessed for gas-sensing performances with exposure to NO2, NH3, and humidity in different conditions such as gate bias and light irradiation. The results show that, compared to the single-layer counterpart, transistors of few MoS2 layers exhibit excellent sensitivity, recovery, and ability to be manipulated by gate bias and green light. Further, our ab initio DFT calculations on single-layer and bilayer MoS2 show that the charge transfer is the reason for the decrease in resistance in the presence of applied field.
Olfactory Response of Larval Diamondback Moth (Lepidoptera: Plutellidae) to Permethrin Formulations (1993)

Odor-mediated behavioral response to permethrin formulations was investigated for two populations (Celeryville, OH, and Geneva, NY)of the diamondback moth, Plutella xylostella (L.). In three-choice olfactory assays, odors from formulations containing 1% or more Ambush or Ambush Blank were significantly avoided by third instars from both populations. The repellent effect was not significant when the concentrations were 0.1% or less. However, 0.01% Ambush Blank was significantly attractive for both populations. Two-choice olfactory assays confirmed the repellent effects of Ambush and Ambush Blank and also showed that 1% Pounce wettable powder formulation was significantly repellent. Technical permethrin did not significantly affect the distribution of larvae from either population. Analyses of how quickly larvae left the arena in the two-choice assays revealed that the permethrin formulations were affecting the speed of larval movement. Larvae moving away from Ambush and, in the case of Celeryville, Ambush Blank, were significantly slower to leave the arena than larvae in corresponding controls. On the other hand, Celeryville larvae that moved toward Pounce wettable powder and larvae from either population that moved toward technical permethrin odors left the test arena significantly more quickly than larvae in corresponding controls. This study indicates that odors from both the active and inert components of permethrin formulations affect larval behavior in ways that could increase the probability of survival in a treated area. Furthermore, contact with deposits is not necessary to elicit these behavioral changes.
Comparing Partial Sums with Their Penultimate Terms: 10433 (1998)

Daniel R. L. Brown, Kenneth R. Davidson, Jeffrey Shallit, Kiran S. Kedlaya, Richard Holzsager, Comparing Partial Sums with Their Penultimate Terms: 10433, The American Mathematical Monthly, Vol. 105, No. 5 (May, 1998), pp. 466-468