gebhart/patrepeval huggingface dataset:
Adaptive Rate-Distortion Optimized Multiple Loop Filtering Algorithm (2010)

고해상도 비디오에 대한 압축 성능 향상을 위해 ITU-T VCEG에서는 H.264/AVC 표준을 근간으로 다양한 압축 성능 개선 기법들을 추가해 왔는데, 그중 ALF 기법은 양자화에 의해 발생한 오류를 제거할 수 있는 필터링 방법을 제공함으로써, 고해상도 영상에서 평균 9%의 매우 높은 성능 개선 능력을 보이는 핵심 기술이다. 하지만 기존의 ALF는 한 프레임 내에서 하나의 Wiener 필터만을 사용하므로, 다수의 서로 다른 통계적 특성을 가진 영역이 존재하는 경우에는 능률적인 오류 복원 성능을 제공하기 어려운 한계를 가지고 있다. 따라서 본 논문에서는 한 복호 프레임에 존재하는 다양한 영역 별 통계적 특성을 반영하여 보다 유연한 율-왜곡 관점에서의 ALF 선택이 가능할 수 있도록, 적응적 율-왜곡 최적 다중 루프 필터 기법을 제안한다. 제안 알고리즘을 통해 다양한 영상에 대하여 기존 알고리즘의 성능을 안정적으로 개선할 수 있었으며, 영상에 뚜렷한 특성 차이를 지닌 복수의 오브젝트가 존재할 경우에는 더욱 높은 비트율 감소 이득을 얻을 수 있었다. At 37th VCEG meeting in Jan. 2009, Toshiba proposed Quadtree-based Adaptive Loop Filter (QALF). The basic concept of QALF is to apply Wiener filter to decoded image after the conventional deblocking filter and to represent the filter on/off flag data for each basic filtering unit in a more efficient way of quadtree structure. QALF could enhance the compression performance of around more than 9%, but the structure of one filter for a decoded frame leaves room for further improvement in the sense that optimal filter for one region of a frame could quite different from the optimal filter for other parts of a picture. This paper proposes multiple adaptive loop filters for better utilization of local characteristics of decoded frame to optimize the region-based Wiener filters. Additional filters, proposed in this paper, cover separate spatial area of each decoded frame according to the performance of previously designed filter(s) to provide the flexibility of rate-distortion based selection of the number of filters.
ChemInform Abstract: Potelligent Antibodies as Next Generation Therapeutic Antibodies (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Adducts of Group III trihalides with trimethylamine and trimethylphosphine (1968)

Vibrational spectra are reported for MX3,NMe3(M = Ga, Al; X = Cl, Br, I) and AlCl3,py. Cryoscopic molecular weights in benzene are given for all these trimethylamine adducts, except in the case of GaBr3,NMe3. The results show the presence of a four-co-ordinated monomeric species in all cases. The formation of AlCl3,2Me3P, GaCl3,Me3P, InCl3,2Me3P, and Inl3,2Me3P is shown to result from the interaction of the appropriate halide with excess of trimethylphosphine. The vibrational spectra of these species are closely comparable with those of the related trimethylamine adducts.
Sonochemical Coating of Paper by Microbiocidal Silver Nanoparticles (2011)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionSonochemical Coating of Paper by Microbiocidal Silver NanoparticlesRonen Gottesman, Sourabh Shukla, Nina Perkas, Leonid A. Solovyov, Yeshayahu Nitzan , and Aharon Gedanken*Cite this: Langmuir 2011, 27, 16, 10340Publication Date (Web):July 21, 2011Publication History Published online21 July 2011Published inissue 16 August 2011https://pubs.acs.org/doi/10.1021/la202211phttps://doi.org/10.1021/la202211pcorrectionACS PublicationsCopyright © 2011 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views593Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (597 KB) Get e-Alertsclose Get e-Alerts
Capillary Zone Electrophoresis-Top-Down Tandem Mass Spectrometry for In-Depth Characterization of Hemoglobin Proteoforms in Clinical and Veterinary Samples (2020)

Hemoglobin (Hb) constitutes an important protein in clinical diagnostics-both in humans and animals. Among the high number of sequence variants, some can cause severe diseases. Moreover, chemical modifications such as glycation and carbamylation serve as important biomarkers for conditions such as diabetes and kidney diseases. In clinical routine analysis of glycated Hb, sequence variants or other Hb proteoforms can cause interference, resulting in wrong quantification results. We present a versatile and flexible capillary zone electrophoresis-mass spectrometry screening method for Hb proteoforms including sequence variants and modified species extracted from dried blood spot (DBS) samples with virtually no sample preparation. High separation power was achieved by application of a 5-layers successive multiple ionic polymer layers-coated capillary, enabling separation of positional isomers of glycated α- and β-chains on the intact level. Quantification of glycated Hb was in good correlation with the results obtained in a clinical routine method. Identification and characterization of known and unknown proteoforms was performed by fragmentation of intact precursor ions. N-Terminal and lysine glycation could be identified on the α- and β-chain, respectively. The versatility of the method was demonstrated by application to dog and cat DBS samples. We discovered a putative new sequence variant of the β-chain in dog (T38 → A). The presented method enables separation, characterization, and quantification of intact proteoforms, including positional isomers of glycated species in a single run. Combined with the simple sample preparation, our method represents a valuable tool to be used for deeper characterization of clinical and veterinary samples.
Linking gene expression and phenotypic changes in the developmental and evolutionary origins of osteosclerosis in the ribs of bowhead whales ( Balaena mysticetus ) (2020)

Bowhead whales are among the longest-lived mammals with an extreme lifespan of about 211 years. During the first 25 years of their lives, rib bones increase in mineral density and the medulla transitions from compact to trabecular bone. Molecular drivers associated with these phenotypic changes in bone remain unknown. This study assessed expression levels of osteogenic genes from samples of rib bones of bowheads. Samples were harvested from prenatal to 86-year-old whales, representing the first third of the bowhead lifespan. Fetal to 2-year-old bowheads showed expression levels consistent with the rapid deposition of the bone extracellular matrix. Sexually mature animals showed expression levels associated with low rates of osteogenesis and increased osteoclastogenesis. After the first 25 years of life, declines in osteogenesis corresponded with increased expression of EZH2, an epigenetic regulator of osteogenesis. These findings suggest EZH2 may be at least one epigenetic modifier that contributes to the age-related changes in the rib bone phenotype along with the transition from compact to trabecular bone. Ancient cetaceans and their fossil relatives also display these phenotypes, suggesting EZH2 may have shaped the skeleton of whales in evolutionary history.
Adenocarcinoma of the head of the pancreas: determination of surgical unresectability with thin-section pancreatic-phase helical CT. (1999)

In patients with adenocarcinoma in the head of the pancreas, the degree of circumferential vessel involvement by tumor as shown by CT is useful in predicting which patients will have surgically unresectable tumors. A dilated gastrocolic trunk should not be used as an independent sign of surgical unresectability.
Design and Implementation of the Data Broadcasting System using Data Piping (2003)

본 논문은 ATSC 디지털데이터 방송 표준을 이용하여 디지털 데이터 방송을 구현하는 시스템을 제안한다. 이 시스템은 MPEG-2 트랜스포트 스트림의 payload 부분에 ATSC 데이터 방송 표준에서 제안하는 데이터 파이핑 기능을 이용하여 사용자에 의해 정의된 URL 정보나 HTML 형태의 데이터를 삽입하고, 이 트랜스포트 스트림이 방송을 통해 DTV set-top에 전송된다. 수신부는 TS 패킷에 있는 데이터를 파싱하여 방송 중에 관련 데이터를 TV에 표시한다. 이 시스템은 기존의 인터넷 컨텐츠를 디지털 데이터 방송에 이용할 수 있는 방안을 제시하며, 기존의 TV나 DTV를 통해 사용자가 쉽게 기존의 인터넷 컨텐츠를 볼 수 있는 시스템을 제안한다. In this paper, we propose a prototype system of digital data broadcasting system based on the ATSC data broadcasting standard. This prototype system uses data piping as a mechanism for delivery of arbitrary user-defined data inserted directly into the payload part of the MPEG-2 Transport Stream packets. This data type includes URL or HTML content. After the contents are inserted into the MPEG-2 Transport Stream, they can be delivered through the broadcasting to the DTV set-top receiver. The 75 packets received in real-time during the TV broadcast are used to start display or switch content. This prototype system describes how to achieve common design goals and integrating digital TV and web pages based on the ATSC data broadcasting standard. The prototype system can be used to display digital data contents - HTML, images-on existing TV or digital TV set-tops.
A Tunable C-plus-L-Band Fiber Ring Laser Based on Hybrid Amplifier (2004)

A tunable C-plus-L-band fiber ring laser, based on a semiconductor optical amplifier, which directly connects an erbium-doped fiber amplifier with a 16 m long erbium-doped fiber, has been proposed and experimentally investigated. A side-mode suppression ratio of >40 dB/0.1 nm and an output power of >3 dBm in the operating range from 1552 to 1610 nm have been achieved for this ring laser.
Smart impact management devices: experimental validation of impact triggered rapid expansion of aluminum honeycomb (2006)

A major limitation of current dedicated impact energy management structures and passive devices used in the transportation industry is that their starting volume is their maximum volume, i.e. they dissipate energy by crushing or stroking from a larger to a smaller volume. This space so occupied is not available for other uses, including such necessary/desirable functions as vehicle serviceability and repair, operational clearances, and interior spaciousness. This limitation has led to the proposal of a class of "smart" impact energy management devices, based on unexpanded aluminum honeycomb (HOBE), that initially occupy a small volume and based on sensor input are rapidly expanded to a much larger crushable volume (nominally 75 times greater) just prior to or in response to an impact. This paper documents the first portion of an experimental exploration of the viability of this technology. Specific goals of the herein documented test program were the demonstration, starting from blocks of unexpanded aluminum honeycomb, a) of the feasibility (and robustness) of sensor triggered rapid expansion both in terms of the integrity and uniformity of the resulting expanded honeycomb, and b) that expansion mechanisms that were required could be simple and have low energy/force requirements. The test program documented here was successful in both respects, demonstrating and thus validating the feasibility and robustness of low energy rapid expansion of aluminum honeycomb.
Implication de la cascade du complément dans les formes sévères de COVID-19 (2021)

The complement system is an essential component of the innate immune system. Its excessive activation during COVID-19 contributes to cytokine storm, disease-specific endothelial inflammation (endotheliitis) and thrombosis that comes with the disease. Targeted therapies of complement inhibition in COVID-19, in particular blocking the C5a-C5aR1 axis have to be taken into account in the establishment of potential biomarkers and development of therapeutic strategies in the most severe forms of the disease.
Degradation Kinetics of Testosterone by Manure‐Borne Bacteria: Influence of Temperature, pH, Glucose Amendments, and Dissolved Oxygen (2010)

Land application of manure may contribute endocrine disrupting compounds (EDCs) such as steroid hormones to the environment. Little attention has been paid to the potential for degradation of steroid hormones by manure-borne bacteria and their degradation kinetics and pathways. In a laboratory study, the potential for biodegradation of testosterone, 17beta-estradiol (E2) and progesterone by swine (Sus scrofa) manure-borne bacteria was examined. In addition, the impact of temperature, pH (6, 7, and 7.5), glucose amendments (0, 3, and 22 mmol L(-1)), and presence of oxygen on testosterone degradation kinetics was determined. Testosterone, 17beta-estradiol and progesterone were biodegraded within 25 h of reaction initiation under aerobic conditions. The degradation of testosterone followed pseudo first-order and zero-order reaction kinetics under aerobic and anaerobic conditions, respectively, in tryptic soy broth (TSB) pre-enriched systems. The half-life (t1/2) for the degradation of testosterone under anaerobic conditions was six times longer than aerobic conditions. Testosterone degradation was found to significantly increase (- 17%) when incubated at 37 degrees C vs. 22 degrees C. The impact of pH (t1/2 ranged from 4.4-4.9 h) and glucose amendments (t1/2 ranged from 4.6-5.1 h) on the testosterone degradation rate were found to be small. Testosterone was transformed to dehydrotestosterone (DHT) (major degradation product), androstenedione (AD), and androstadienedione (ADD) under aerobic conditions as revealed by liquid chromatography-time-of-flight mass spectrometry (LC/TOF-MS). These results indicate that testosterone is rapidly degraded by manure-borne bacteria under a wide range of environmentally relevant conditions. However, the formed degradation products are still of potential concern due to their endocrine disrupting potential.
Supplementary Figure 1 from Patients with Biallelic BRCA1/2 Inactivation Respond to Olaparib Treatment Across Histologic Tumor Types (2023)

&lt;p&gt;Flow chart of patients with BRCA1/2 alterations submitted to the study team between September 2016 and December 2019, and reasons for drop-out, rejection or screen failure. Abbreviations: VUS = Variant of Unknown Significance, LOH = Loss of Heterozygosity.&lt;/p&gt;
94 High Immunogenicity of the Allergen PHL P 5 Expressed in Transgenic Mice as a Membrane-anchored Protein (2012)

BACKGROUND: Induction of long-term tolerance towards Phl p 5 was previously achieved by transplantation of hematopoetic stem cells (HSCs) genetically modified to express membrane-bound Phl p 5 allergen. To facilitate the further development of tolerogenic cell therapies for allergy, a transgenic mouse expressing Phl p 5 ubiquitously as membrane-anchored protein, was generated. Here we investigated the immunogenicity of the membrane-anchored version of Phl p 5. METHODS: The Phl p 5-transgenic mouse (Balb/c background) was generated by pronuclear injection integrating Phl p 5 fused to a leader peptide and a transmembrane domain under control of a CMV-promotor with a GFP-reporter. Splenocytes (2.5 × 10(6) per mouse), cell extracts containing mainly membrane proteins and recombinant (r) Phl p 5 [5 μg+/− Al(OH)(3) per mouse] were injected subcutaneously into naïve Balb/c mice (n = 8 per group). The amount of Phl p 5 of splenocytes and cell extracts was semi-quantitatively determined via western blotting. Furthermore skin of Phl p 5-transgenic mice was grafted onto naïve Balb/c (n = 13 in 2 independent experiments), a rejection model in allo-transplantation since skin is highly immunogenic and therefore readily rejected. Phl p 5-specific antibody response was determined in sera by ELISAs. For T-cell responses splenocyte-proliferation was assessed in vitro after stimulation with rPhl p 5. RESULTS: Surprisingly, a prompt rejection (within 8-10 days) was elicited, accompanied by a strong Phl p 5 specific antibody response including Phl p 5-specific IgE in wildtype Balb/c after skin rejection of Phl p 5-transgenic mice. Additionally to the skin grafted group, mice receiving splenocytes or rPhl p 5 plus adjuvant showed a comparable response in matters of Phl p 5-specific IgE- and IgG1-levels through the whole follow-up (week 1, 2, 3, 5, 7, 9, 11) suggesting an unusually strong immune response to cell or tissue-bound Phl p 5. Furthermore Phl p 5-specific IgG2a/2b/3, IgA and IgM were induced. Besides in vitro splenocyte-proliferation assays showed Phl p 5 specific T-cell responses in all groups of mice that showed strong humoral responses. CONCLUSIONS: The high immunogenicity of tissue-bound Phl p 5 may represent a new mode of rendering antigens highly immunogenic.
Effects of Mobility Changes and Distribution of Bipolar Ions on Aerosol Nanoparticle Diffusion Charging (2005)

Changes in the mobility of bipolar ions due to water vapor in the medium gas and the effect of the change on the aerosol particle charging states were investigated, both experimentally and theoretically. Particle charging equations regarding the mobility distributions of bipolar ions were also derived from basic particle charging equations (Marlow and Brock, 1975; Adachi et al., 1985; Reischl et al., 1996) and confirmed by comparison with experimentally obtained data. For positive ions, the peak electrical mobility was very stable and independent of water vapor concentration, but for the case of negative ions, a considerable increase with water vapor concentration was found. The change in negative ion mobility had a more significant effect on the positive charging ratio of aerosol particles than a negative one, indicating that negatively charged particles are more amenable than positively charged ones to aerosol particle measurement using a differential mobility analyzer. Since a better agreement was found between experimental and calculated results by the solution for the ion mobility distribution than the basic charging equation, it would be expected that particle charging equations regarding mobility distribution would be applicable to a determination of particle charging ratio when many types of bipolar ions are simultaneously present in a particle charging space.
Emerging Developments in Targeting Proteotoxicity in Neurodegenerative Diseases (2019)

The most common neurodegenerative diseases are Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease, frontotemporal lobar degeneration, and the motor neuron diseases, with AD affecting approximately 6% of people aged 65 years and older, and PD affecting approximately 1% of people aged over 60 years. Specific proteins are associated with these neurodegenerative diseases, as determined by both immunohistochemical studies on post-mortem tissue and genetic screening, where protein misfolding and aggregation are key hallmarks. Many of these proteins are shown to misfold and aggregate into soluble non-native oligomers and large insoluble protein deposits (fibrils and plaques), both of which may exert a toxic gain of function. Proteotoxicity has been examined intensively in cell culture and in in vivo models, and clinical trials of methods to attenuate proteotoxicity are relatively new. Therapies to enhance cellular protein quality control mechanisms such as upregulation of chaperones and clearance/degradation pathways, as well as immunotherapies against toxic protein conformations, are being actively pursued. In this article, we summarize the common pathophysiology of neurodegenerative disease, and review therapies in early-phase clinical trials that target the proteotoxic component of several neurodegenerative diseases.
Interpretation of Real-Time PCR Results for Hepatitis C Virus RNA When Viral Load Is Below Quantification Limits (2011)

Hepatitis C virus RNA quantification results obtained in 18 laboratories using real-time PCR methods with 10 negative samples and 22 sample dilutions (viral loads of 0.5 to 500 IU/ml) showed a score of correct results of up to 93.5%. However, 55.6% of the laboratories did not follow the recommendations for the interpretation of their results, leading to ambiguous conclusions.
External Quality Assessment 2.0: The Importance of a Standardized Implementation of TILs for Daily and Trial Practices (2022)

Increasing data suggests that an intact immune system is required for improvedoutcomes in patients with Human Epidermal Growth Factor Receptor 2 (HER2+) and Triple Negative Breast Cancer (TNBC) [...].
Piles à combustible : principes et quelques effets non linéaires (2010)

Mini-colloque 2010 : Le non-linéaire, une clé des énergies de demain ?
Ptychographic amplitude and phase reconstruction of bichromatic vortex beams (2018)

We experimentally demonstrate that ptychographic coherent diffractive imaging can be used to simultaneously characterize the amplitude and phase of bichromatic orbital angular momenta-shaped vortex beams, which consist of a fundamental field, together with its copropagating second-harmonic field. In contrast to most other orbital angular momentum characterization methods, this approach solves for the complex field of a hyperspectral beam. This technique can also be used to characterize other phase-structured illumination beams, and, in the future, will be able to be extended to other complex fields in the extreme ultraviolet or X-ray spectral regions, as well as to matter waves.
Structural Characterization of Picket-fence Porphyrinatoiron with .OMEGA.-Hydroxy-2,2-dimethylicosanoyl Side-chains vs. .OMEGA.-Cholinephosphoryl-2,2-dimethylicosanoyl Side-chains by FAB High-energy-CID MS/MS. (1998)

Applicability of FAB high-energy-CID MS/MS to structural characterization of two types of tetraphenylporphyrin (TPP)-derivatives was examined. These tetraphenylporphyrin (TPP)-derivatives, 20-hydroxy-2,2-dimethylicosanoyl picket-fence porphyrinatoiron and 20-cholinephosphoryl-2,2-dimethylicosanoyl picket-fence porphyrinatoiron have four 2,2-dimethylicosanamido long-chains in common in their structures, which keep a balance between hydrophobic and hydrophilic properties. The structural difference between the two compounds is that the former has a hydroxyl group at the remote end of the 2,2-dimethylicosanamido long-chain, while the latter has a phosphocholine ester functional group at the remote-end. This structural difference gives rise to different features as well as some analogies in their FAB and the high-energy-CID MS/MS spectra. Differences and analogies in those spectra were also noted between the long-chain porphyrin derivatives we are describing here and the pivaloyl-type porphyrins we reported previously [T. Shibue, H. Kambe, H. Nishide, S. Akashi, N. Dohmae, and Y. Ohashi, Eur. Mass Spectrom., 3, 291-299 (1997)]. By selecting a precursor ion at m/z 476, which corresponds to the 20-cholinephosphoryl-2,2-dimethylicosanoyl group, charge-remote fragmentation was observed. This observation reminded us our previous study on the imidazole-tailed picket-fence porphyrin fragmentations.
Compact and efficient laser-wavelength converters for domiciliary treatment (2007)

レーザーの波長変換デバイスは過去10年の間に劇的な進歩をとげ，小型光源用のシングルパス変換や多波長発生の設計が可能になった．分極反転を用いた高効率擬似位相整合波長変換デバイスにより，光源から複雑な共振器構造が省かれて光源の形態が大きく変わろうとしており，在宅治療用具として適した安定なツールに飛翔する可能性がある．中赤外発生用波長変換デバイスの最近の進歩についてここでは報告する．