gebhart/patrepeval huggingface dataset:
Evolving Therapies for the Treatment of HCV Viral Hepatitis (2014)

ADVERTISEMENT RETURN TO ISSUEPREVEditorialNEXTEvolving Therapies for the Treatment of HCV Viral HepatitisGeorge PainterView Author Information CEO, DRIVE—Drug Innovation Ventures at Emory, LLC.Cite this: ACS Med. Chem. Lett. 2014, 5, 3, 212–213Publication Date (Web):March 13, 2014Publication History Published online13 March 2014Published inissue 13 March 2014https://pubs.acs.org/doi/10.1021/ml500064yhttps://doi.org/10.1021/ml500064yeditorialACS PublicationsCopyright © 2014 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views598Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (132 KB) Get e-AlertscloseSUBJECTS:Anatomy,Hepatitis,Infectious diseases,Pharmaceuticals,Viruses Get e-Alerts
Pt-Ru Alloys Deposited by Sputtering as Catalysts for Methanol Oxidation (2008)

Using rf co-sputtering, we have successfully deposited Pt-Ru catalysts of well controlled Ru content over a wide range of compositions. The surface morphology of the films, acquired from scanning electron microscopy studies, is very rough and nanoporous. The structure of the films has been verified as polycrystalline by x-ray diffraction analysis. The electrochemical behavior of the electrodes has been characterized using chronoamperometry with methanol oxidation as the probe reaction in a H2SO4/MeOH electrolyte at room temperature. The results indicate that the optimal stoichiometry of the alloys measured in 1 M MeOH and 16.6 M MeOH is Ru0.24Pt0.76 and Ru0.46Pt0.54, respectively. These alloys have an onset potential 0.2 volt lower than pure Pt.
Reflection-type diffractive optical element employing SiC and Si for application to high power laser material processing (2020)

We successfully prepared reflection-type diffractive optical elements (R-DOEs) using SiC and Si wafers for application to high-power laser material processing. SiC and Si, whose thermal conductivity are 200 W/mꞏK, are preferred materials to be cooled by water to prevent thermal lens effect. Our calculation revealed that these R-DOEs achieved 30-kW laser processing by using water cooling on the backside of these R-DOEs. Measured energy conversion efficiencies were 75% using a single-mode laser with a wavelength of 1.064 &mu;m. Moreover, the integrated intensities of a reconstructed image measured using both single-mode and multi-mode lasers were almost the same. We also succeeded in designing a simple cooling unit. Distortion of these R-DOEs caused by water pressure was also measured to prevent any change in focusing length and distortion of the shaped beam. The measured curvature radius was 100 mm, in which there was a -0.3-mm change in focusing length. The measured reconstructed image was not distorted. We experimentally confirmed that the laser irradiation tolerance of the combined R-DOE and cooling unit was more than 10-kW. These results corresponded well with our theoretical estimation. These results suggest reflection-type DOEs are a good beam shaper for high power laser processing using more-than-10-kW laser sources.
Visualizing Native Cell Nano-architecture During Early Carcinogenesis Using Scanning Transmission Electron Microscopy (2012)

Extended abstract of a paper presented at Microscopy and Microanalysis 2012 in Phoenix, Arizona, USA, July 29 – August 2, 2012.
A pore-scale study of bacterial chemotaxis with segregated and controlled nutrient sources (2022)

&amp;lt;p&amp;gt;Natural porous systems, like soils and aquifers, are physically and chemically highly heterogeneous. Microorganisms inhabiting these environments are therefore exposed to heterogeneous fluid flow velocities and nutrient landscapes. Bacteria capable of biasing their motion to swim along chemical gradients &amp;amp;#8211; known as chemotaxis &amp;amp;#8211; profit from their ability to localize and navigate towards nutrient hot spots, such as soil aggregates or plant roots.&amp;lt;br&amp;gt;We propose a novel experimental microfluidic platform to study chemotaxis at the pore-scale, allowing full optical access to the pore space and simultaneously enabling control over the spatio-temporal availability of nutrients. The microfluidic device contains hydrogel features, acting as nutrient hotspots, embedded in a porous medium, made out of transparent polydimethylsiloxane (PDMS) pillars. Nutrients are transported by diffusion from the access channels through the hydrogel into the porous medium, where they are released. The generated nutrient gradients downstream of the hotspots under flow conditions drive the swimming of chemotactic bacteria.&amp;lt;br&amp;gt;This approach enables the study of subsurface processes at the pore-scale under more realistic conditions, and shed new light onto the influence of physical and chemical heterogeneity on bacterial dispersion and residence time in the subsurface.&amp;lt;/p&amp;gt;&amp;lt;p&amp;gt;Keywords: porous media, soil, chemotaxis, microfluidics, heterogeneity&amp;lt;/p&amp;gt;
High-Speed Optical Communications Systems for Future WDM Centralized Radio Access Networks (2021)

Several modulation techniques aimed at ensuring high capacity and low latency for next generation of mobile transport networks are discussed. Centralized radio access networks are considered based on WDM transmission to ensure long distance, sufficient number of antenna sites and segregation of heterogeneous connectivity services over the same fiber infrastructure. Of all the proposed techniques, attention is paid to those allowing for low-cost transceivers. With increasing bit-rate, when considering distances in the order of 20&#x00A0;km, the most significant impairment is the fiber chromatic dispersion. The reasons dispersion compensating fiber modules are to be avoided in a mobile transport network are discussed and modulation formats resilient to fiber chromatic dispersion are examined to check for the highest achievable bit-rate when using direct-detection receivers. It is shown that, when using binary formats, the combined amplitude-phase shift (CAPS) codes allow to bridge a distance of 15&#x00A0;km or more with a significant power budget advantage over PAM-4. However, higher modulation formats such as PAM-4 allow for slower electronics speed. When halving the speed of electronics is desirable and optical amplification is employed, a bipolar PAM-4 format allows for an improved power budget. One of the results of this paper is that, without any signal processing or dispersion compensators and without exploiting polarization modulation, direct-detection formats cannot be employed to bridge distances of the order of 20&#x00A0;km at a bit-rate greater than about 50&#x00A0;Gb/s. To achieve higher rates, coherent detection is needed and we also discuss a low-cost implementation avoiding a local oscillator for detection.
Estimation of Geomechanical Failure Parameters from Well Logs Using Artificial Intelligence Techniques (2017)

Abstract Geomechanical failure parameters are best estimated from core samples, which are not always available. To address this, numerous relationships have been proposed that relate rock strength to parameters measurable with geophysical well logs, but they tend to have limited accuracy or low range of applicability. This paper aims at overcoming the limitations of the existing techniques by using different artificial intelligence techniques (AI). The data used in this study are usually available from the commonly conducted well log surveys (neutron porosity, gamma ray and bulk density) as well as the sonic log. Data sets from 10 wells in carbonate formations and 30 core samples were used to build a simple, yet powerful, model that can predict the rock failure parameters from well logs. The derived model is working because it considers many factors that affect both the rock strength and elastic moduli. Three artificial intelligence techniques; Artificial Neural Networks (ANNs), Adaptive Neuro-Fuzzy Inference System (ANFIS), and Support Vector Machines (SVM) were used to predict three geomechanical failure parameters, namely: the angle of internal friction (friction angle or FANG), unconfined compressive strength (UCS) and tensile strength (TSTR). For each parameter, the three AI techniques were implemented to train AI models and then unseen data was used to validate the models. From the three tested AI techniques, ANN model gave the best results and out-performed the other models obtained using ANFIS and SVM for the FANG prediction, with correlation coefficient of 0.98 and AAPE around 5.8%. The ANN model was programmed in a (white box) manner, which allowed the successful extraction of the weights and biases from the network to be easily used. For TSTR and UCS prediction, ANFIS models performed better than ANN and SVM. The two ANFIS models had correlation coefficients of 0.99 and Average Absolute Percentage Errors (AAPE) of 4.9% and 3.7% respectively.
Low-via-resistance and low-cost PVD-TiZrN barrier for Cu/low-K interconnects (2016)

In this work, a low-resistance and low-cost PVD-TiZrN barrier is evaluated for BEOL interconnect. Comparing to conventional PVD barrier, comparable Cu barrier and Cu wetting properties are obtained. Moreover, up to 55% of via resistance reduction is achieved, with comparable voltage breakdown performance comparing to conventional one.
Modeling and synthesis of wide-band switched-resonators for VCOs (2008)

A two-level switched resonator model for synthesizing a wide-tuning range LC VCO is described. Viable resonator design styles are selected for achieving broadband frequency synthesis. A simple, generalized model is developed for design space exploration. Using this model, based on the performance specifications, a resonator style is selected. Also, the performance specifications are translated to individual resonator components. At the second level, detailed models for the resonator components are developed. The resonator is then designed and simulated based on these models. As an example, a wideband VCO using a new inductor switching technique is explored. Simulations performed in a 0.18 mum CMOS process achieved a tuning range from 3.35 to 8.34 GHz while exhibiting phase noise between -107 and -119 dBc/Hz at 1 MHz offset over the entire range. The VCO core dissipated 1.9 to 8.3 mW power using a 1.8-V supply.
Negative Index Metamaterials for Visible Wavelengths (2009)

We report on a metamaterial sample that demonstrates double-negative index behavior at the shortest wavelength to date. We also discuss the controlled resonance tuning of optical magnetism in materials by using of liquid crystals.
Cone Voltage Dissociation (2016)

This document contains recommendations for terminology in mass spectrometry. Development of standard terms dates back to 1974 when the IUPAC Commission on Analytical Nomenclature issued recommendations on mass spectrometry terms and definitions. In 1978, the IUPAC Commission on Molecular Structure and Spectroscopy updated and extended the recommendations and made further recommendations regarding symbols, acronyms, and abbreviations. The IUPAC Physical Chemistry Division Commission on Molecular Structure and Spectroscopy’s Subcommittee on Mass Spectroscopy revised the recommended terms in 1991 and appended terms relating to vacuum technology. Some additional terms related to tandem mass spectrometry were added in 1993 and accelerator mass spectrometry in 1994. Owing to the rapid expansion of the field in the intervening years, particularly in mass spectrometry of biomolecules, a further revision of the recommendations has become necessary. This document contains a comprehensive revision of mass spectrometry terminology that represents the current consensus of the mass spectrometry community.
Planning wafer allocation for CMOS process development. A nonparametric approach (1998)

In this paper, we present techniques that can be used to answer the following two questions: (1) how many wafers need to be allocated per treatment to detect a given difference in a device performance metric and (2) how can one determine if a given treatment significantly improved a performance metric? The approach presented here does not make any assumptions regarding the shape of the distribution or the spatial dependency structure for the within-wafer performance measurements and remains applicable for a variety of performance metrics, such as mean, variance, and median. The analysis method can be used in decisions regarding the appropriateness of allocating half or quarter wafer splits to a treatment. Furthermore, the approach allows us to evaluate and compare within-wafer sampling strategies for comparing performance metrics from competing flows.
Analysis of Volatile Mouse Pheromones by Gas Chromatography Mass Spectrometry (2013)

High-precision quantitative profiling of volatile organic constituents in rodent physiological fluids and glandular secretions is needed to relate olfactory signals to physiology and behavior. Whereas capillary gas chromatography-mass spectrometry (GC-MS) analysis has become the most widely applied in such investigations, the extraction and preconcentration of volatile organics is arguably the most critical step in the overall analytical task. In this chapter, we describe technical details of two main sample extraction procedures used in our laboratory: dynamic headspace trapping, and stir bar sorptive extraction (SBSE). They have been demonstrated here for the chromatographic analysis of mouse urine, serum, saliva, and preputial gland specimens.
A multicenter, open-label phase 3 study of emicizumab prophylaxis in children with hemophilia A with inhibitors (2019)

Emicizumab, a bispecific humanized monoclonal antibody, bridges activated factor IX (FIX) and FX to restore the function of missing activated FVIII in hemophilia A. Emicizumab prophylaxis in children with hemophilia A and FVIII inhibitors was investigated in a phase 3 trial (HAVEN 2). Participants, previously receiving episodic/prophylactic bypassing agents (BPAs), were treated with subcutaneous emicizumab: 1.5 mg/kg weekly (group A), 3 mg/kg every 2 weeks (group B), or 6 mg/kg every 4 weeks (group C). Pharmacokinetics, safety, and efficacy (including an intraindividual comparison of participants from a noninterventional study) were evaluated. Eighty-five participants aged <12 years were enrolled. In group A (n = 65), the annualized rate of treated bleeding events (ABRs) was 0.3 (95% confidence interval [CI], 0.17-0.50), and 77% had no treated bleeding events. Intraindividual comparison of 15 participants who previously took BPA prophylaxis showed that emicizumab prophylaxis reduced the ABR by 99% (95% CI, 97.4-99.4). In groups B (n = 10) and C (n = 10), ABRs were 0.2 (95% CI, 0.03-1.72) and 2.2 (95% CI, 0.69-6.81), respectively. The most frequent adverse events were nasopharyngitis and injection-site reactions; no thrombotic events occurred. Two of 88 participants developed antidrug antibodies (ADAs) with neutralizing potential, that is, associated with decreased emicizumab plasma concentrations: 1 experienced loss of efficacy, and, in the other, ADAs disappeared over time without intervention or breakthrough bleeding. All other participants achieved effective emicizumab plasma concentrations, regardless of the treatment regimen. Emicizumab prophylaxis has been shown to be a highly effective novel medication for children with hemophilia A and inhibitors. This trial was registered at www.clinicaltrials.gov as #NCT02795767.
Predicting Temperature Field in Powder-Bed Fusion (PBF) Additive Manufacturing Process Using Radial Basis Neural Network (RBNN) (2022)

Avoiding or eliminating thermal abnormalities in powder bed fusion (PBF) is critical since the abnormalities can lead to a higher failure rate of printing complex parts, a longer manufacturing lead time, and/or additional post-processing. Controlling the thermal evolution of the process can hinder or minimize some of the most frequently encountered thermal abnormalities. To achieve such an objective, the prediction and control of temperature distribution throughout an exposure layer is a crucial step. The generation of uniform temperature distribution throughout the printed layers and the avoidance of overheated zones are two primary sub-objectives for controlling the thermal evolution of the process. However, the complex and non-linear nature of the process has limited the ability to derive a universal analytical equation to correlate the process parameters with the thermal distribution of a printed layer. Laser specifications such as laser power and scanning speed are among the main process parameters that predominantly govern the temperature distribution throughout the layer. In this paper, we employ an artificial neural network (ANN) to correlate laser power with the temperature of the printed area around the melt pool in Inconel 718. In our first variant, we investigate the effectiveness of using the multilayer perceptron Radial Basis Neural Network (RBNN) to model the function for predicting the temperature distribution for various laser power. We use the Rosenthal equation to generate adequate inputs-outputs for training our function. We then compare the output with the simulation results for five different laser powers. The results show that the function was trained successfully with a low mean square root error of 9.7157 using 2000 samples, a wider gap exists between the trained function and the simulated data. In the second variant, we use a recurrent neural network (RNN), which enables temporal histories to be used for training. To fulfill such objective, we acquire real thermal data using a photon-counting IR camera for different printed layers. This step allows the training of a function to predict the temperature distribution precisely for different laser power and thermal history. As future work, we will employ the function to adjust the laser power to minimize the overheated zones and distribute the temperature uniformly throughout each exposure layer.
Supplementary Table 2 from Elimination of IL-10–Inducing T-Helper Epitopes from an IGFBP-2 Vaccine Ensures Potent Antitumor Activity (2023)

&lt;p&gt;PDF file - 65KB, Bacterial sequence homologies for IGFBP-2 C-terminus.&lt;/p&gt;
Detailed analysis of generator emulation control impedance network of microgrid inverters (2011)

Microgrids are self contained, small-scale versions of the centralized electric power system, where power is produced, transmitted, consumed, and managed locally. They can operate as part of a host electrical power system (grid tie) or as stand alone when the main power grid is not available. Achieving a smooth mode transition from grid tie to standalone operation is an important aspect of microgrid operation. The concept of Generator Emulation Control (GEC) has already been proposed as a suitable control strategy for inverters, which offers a seamless and fast transient response especially during mode changes. This paper will present a detailed analysis of the GEC control scheme.
A Low-Complexity Iterative Mimo Sphere Decoding Algorithm (2009)

Publication in the conference proceedings of EUSIPCO, Glasgow, Scotland, 2009
ChemInform Abstract: Unconventional Methods for Fabricating and Patterning Nanostructures (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Measurement of diffractive dissociation cross sections inppcollisions ats=7  TeV (2015)

Measurements of diffractive dissociation cross sections in pp collisions at ffiffi ffi s p 7 TeV are presented in kinematic regions defined by the masses M X and M Y of the two final-state hadronic systems separated by the largest rapidity gap in the event. Differential cross sections are measured as a function of X M 2 X =s in the region -5.5 < log 10 X < -2.5, for log 10 M Y < 0.5, dominated by single dissociation (SD), and 0.5 < log 10 M Y < 1.1, dominated by double dissociation (DD), where M X and M Y are given in GeV. The inclusive pp cross section is also measured as a function of the width of the central pseudorapidity gap for > 3, log 10 M X > 1.1, and log 10 M Y > 1.1, a region dominated by DD. The cross sections integrated over these regions are found to be, respectively, 2.99 AE 0.02stat 0.32 -0.29 syst mb, 1.18 AE 0.02stat AE 0.13syst mb, and 0.58 AE 0.01stat 0.13 -0.11 syst mb, and are used to extract extrapolated total SD and DD cross sections. In addition, the inclusive differential cross section, d=d F , for events with a pseudorapidity gap adjacent to the edge of the detector, is measured over F 8.4 units of pseudorapidity. The results are compared to those of other experiments and to theoretical predictions and found compatible with slowly rising diffractive cross sections as a function of center-of-mass energy.
TOTAL KNEE ARTHROPLASTY AFTER VARUS OSTEOTOMY OF THE DISTAL PART OF THE FEMUR (2003)

Total knee arthroplasty following distal femoral varus osteotomy decreases pain and improves knee function, but the procedure is technically demanding and is associated with inferior results when compared with those of primary arthroplasty performed in a patient without a prior femoral osteotomy. In the present series, the use of an intramedullary femoral alignment guide increased the tendency to place the femoral component in relative varus angulation (that is, in <5 degrees of valgus). We recommend checking the alignment of the femoral component with an extramedullary guide in knees that have had a previous distal femoral varus osteotomy.