gebhart/patrepeval huggingface dataset:
The enhanced mucolytic activity of human pepsin 1 compared with pepsin 3: implications in peptic ulceration (1984)

Conference Article| October 01 1984 The enhanced mucolytic activity of human pepsin 1 compared with pepsin 3: implications in peptic ulceration JEFFREY P. PEARSON; JEFFREY P. PEARSON *Department of Physiological Sciences, University of Newcastle upon Tyne NE1 7RU, U.K. Search for other works by this author on: This Site PubMed Google Scholar NORMAN B. ROBERTS; NORMAN B. ROBERTS †Department of Chemical Pathology and Metabolic Medicine, Royal Liverpool Hospital, Prescot Street, Liverpool L7 8XW, U.K. Search for other works by this author on: This Site PubMed Google Scholar WILLIAM H. TAYLOR WILLIAM H. TAYLOR †Department of Chemical Pathology and Metabolic Medicine, Royal Liverpool Hospital, Prescot Street, Liverpool L7 8XW, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1984) 12 (5): 875. https://doi.org/10.1042/bst0120875 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation JEFFREY P. PEARSON, NORMAN B. ROBERTS, WILLIAM H. TAYLOR; The enhanced mucolytic activity of human pepsin 1 compared with pepsin 3: implications in peptic ulceration. Biochem Soc Trans 1 October 1984; 12 (5): 875. doi: https://doi.org/10.1042/bst0120875 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1984 Biochemical Society1984 Article PDF first page preview Close Modal You do not currently have access to this content.
Immuno‐gold localization of IAA in leaf cells of Prunus persica at different stages of development (1992)

Subcellular localization of indole‐3‐acetic acid (IAA) in leaf cells of peach ( Prunus persica [L.] Batsch ‘Hakuho’) was investigated using imuno‐gold electron microscopy. The distribution pattern of the gold particles, which detected IAA, changed as cells matured. The most prominent feature was the accumulation of the gold label in the chloroplasts and mitochondria of the parenchyma cells of opened leaves. Throughout the development, the cytosol, nuclei, and cell wall were labelled, although the level was low and no significant changes occurred. The density of colloidal gold at each stage of leaf development was well correlated with the analytical data obtained by high‐performance liquid chromatography (HPLC).
Yielding in cohesive suspensions part 1: strain softening. (2014)

Many cohesive suspensions in simple shear flow are seen to behave as Herschel-Bulkeley fluids approximately, or, rather they do so at sufficiently high shear-rates. From that perspective it might be said that yield is only glimpsed in the rear-view mirror. The stress coming from inter-particle interactions can then be lumped into a yield stress parameter, an operational or engineering quantity too often taken to be a true material property. In simple shear flow though, yield can alternatively be considered in terms strainsoftening, as is done briefly in this short informal article intended for the Bulletin of the British Society of Rheology. A subsequent article will consider with the role of strain-rate softening too: strongly cohesive and very concentrated suspensions can show highly non-monotonic flow curves, to the point where the yield stress parameterisation fails completely, whereas a description in terms of strain and strain-rate softening functions seem to be more appropriate.
Microbial renewable feedstock utilization (2010)

Increasingly lignocellulosic biomass hydrolysates are used as the feedstock for industrial fermentations. These biomass hydrolysates consist of complex mixtures of different fermentable sugars, but also contain inhibitors and salts that affect the performance of the product-generating microbes. The performance of six industrially relevant microorganisms, i.e., two bacteria (Escherichia coli and Corynebacterium glutamicum), two yeasts (Saccharomyces cerevisiae and Pichia stipitis) and two fungi (Aspergillus niger and Trichoderma reesei) were compared for their ability to utilize and grow on different feedstock hydrolysates (corn stover, wheat straw, sugar cane bagasse and willow wood). Moreover, the ability of the selected hosts to utilize waste glycerol from the biodiesel industry was evaluated. P. stipitis and A. niger were found to be the most versatile and C. glutamicum, and S. cerevisiae were shown to be the least adapted to renewable feedstocks. Clear differences in the utilization of the more abundant carbon sources in these feedstocks were observed between the different species. Moreover, in a species-specific way the production of various metabolites, in particular polyols, alcohols and organic acids was observed during fermentation. Based on the results obtained we conclude that a substrate-oriented instead of the more commonly used product oriented approach towards the selection of a microbial production host will avoid the requirement for extensive metabolic engineering. Instead of introducing multiple substrate utilization and detoxification routes to efficiently utilize lignocellulosic hydrolysates only one biosynthesis route forming the product of interest has to be engineered.
Modeling and tracking temporal fluctuations for underwater acoustic communications (2011)

High-rate, phase-coherent communications through the underwater acoustic channel requires implicitly or explicitly tracking the fluctuations of the channel impulse response. Current techniques estimate the time-varying channel impulse response using observations of signals that have propagated through the channel over some averaging interval and often rely on some method of representing the time variability in the channel. For example, the work by Stojanovic that enabled phase-coherent communications through the underwater channel represented the time-variation as a common phase rotation (Doppler shift) of all taps of the channel impulse response. The tracking of channel fluctuations involves a fundamental trade-off between the number of independent parameters used to represent both the channel impulse response coefficients (i.e., the dimensionality of the estimation problem) and their temporal variations, the rate of channel fluctuations that can be tracked, and the signal to noise ratio (SNR). This talk will present new and review established techniques for modeling time variability and reducing dimensionality in underwater acoustic channel. The performance of these approaches as a function of SNR and rate of channel fluctuation will be compared and their computational complexity will be discussed.
Lectin from Erythrina cristagalli Supports Undifferentiated Growth and Differentiation of Human Pluripotent Stem Cells (2012)

Lectins are carbohydrate-binding proteins, which occur ubiquitously in nature and are abundant in all living organisms from bacteria to mammals. They have several biological functions among which cell adhesion is well known and characterized. Based on the characterization of the glycome of human embryonic stem cells (hESCs), we have investigated the properties of glycan-binding lectins as a novel class of culture support matrices supporting hESC culture. We report that an Erythrina cristagalli lectin (agglutinin) (ECA) matrix supported the undifferentiated growth and significantly increased the plating efficiency of both hESC and human induced pluripotent stem cells when used in conjunction with pinacidil, an antihypertensive drug with ROCK inhibition activity. As a matrix, ECA maintained pluripotency, robust proliferation with a normal karyotype, and the ability to differentiate both in vitro and in vivo. Therefore, our findings indicate that lectins are potential candidates for design of culture and differentiation methods, and that ECA is a potent simple defined matrix for human pluripotent stem cells.
Abstract 487: A comprehensive target enrichment panel for fusion detection (2017)

Abstract Growing interest in cancer classification and progression has accelerated the rate of novel gene fusions discovery with increasing recognition of their roles as biomarkers. RNA-Seq is an attractive method for expressed fusion discovery and detection because of its ability to provide unbiased fusion sequencing information. The ability to detect low expressing fusion transcripts, however, require high sequencing depth and represents a significant financial barrier and identification of clinically relevant fusion sequences from a large data set can be a bioinformatics challenge. To address these challenges we have tested the Ovation® Fusion Panel Target Enrichment System V2, a targeted RNA sequencing method using the Single Primer Enrichment Technology (SPET), with a number of control and clinical samples. Initial studies were performed using a comprehensive target enrichment panel targeting 502 genes with three samples from Horizon DX containing known fusions. Target enriched libraries were constructed with 10 ng and 100 ng inputs and the data was analyzed using the NuFuseD pipeline (available as a point and click BaseSpace application or downloadable linux package) which has been optimized for fusion analysis from this data. Expected fusions were identified at both input levels, even when down sampled to 500K reads, with fewer fusion calls compared to other publically available fusion detection software (Chimerascan and SOAPFuse), suggesting a lower false positive rate. NuFuseD fusion calls are provided with a P-value to help prioritize the identified fusions for subsequent validation. Additionally, NuFuseD detected novel fusions in the control samples demonstrating the advantage of a comprehensive panel compared to more restricted panels. We further validated the target panel using control RNA (UHR and Human Brain) and fresh or FFPE cell lines (NCI-H2228, HCC1937) to further demonstrate our ability to identify known fusions. Finally, the system was evaluated at an external site using patient FFPE samples. These samples (N=8) were from a set of breast, liver and ovarian cancers, containing a unique fusion in 4 of the samples based on DNA based sequencing. Only 1 of the 4 expected fusions were identified using whole transcriptome data (100 million reads) while 3 of the 4 fusions were detected with this assay (10 million reads) demonstrating its ability to generate targeted RNA sequencing libraries with increased sensitivity of gene fusion detection and reduced sequencing costs compared to standard RNA-Seq methods. Citation Format: Ashesh Saraiya, Brandon Young, Tobias Meißner, Brian L. Jones, Stephanie C. Huelga, Doug A. Amorese. A comprehensive target enrichment panel for fusion detection [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 487. doi:10.1158/1538-7445.AM2017-487
Novel antifungal antibiotics octacosamicins A and B. I. Taxonomy, fermentation and isolation, physico-chemical properties and biological activities. (1988)

Two antifungal antibiotics octacosamicins A and B were isolated from the culture broth of a strain of actinomycetes, which was identified as a strain of Amycolatopsis. These antibiotics were isolated by resin adsorption and purified by column chromatography and preparative HPLC. Both antibiotics were found to be new substances from their physico-chemical properties. They showed broad antifungal spectra.
Design and construction of an optimal illumination system for quantitative wide‐field multi‐dimensional microscopy (1993)

A new modular transmission and fluorescence illumination system has been designed and built. The approach utilizes fiber optics to scramble the spatial intensity variations and digital monitoring of light intensity to allow accurate correction for inherent temporal instability. The illumination system has been characterized by a variety of methods and is shown to have an evenly filled objective back focal plane for maximal resolution in all three axes. The use of this illumination system in conjunction with a scientific grade CCD camera and pixel-by-pixel correction makes possible data of such high quality as to be only limited by the photon counting statistics. This illumination approach has proven to be particularly important for three-dimensional imaging coupled with image processing to remove out-of-focus information.
ChemInform Abstract: Amperometric Gas Sensors — A Review (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Sensitive detection of nanomechanical motion using piezoresistive signal downmixing (2005)

We have developed a method of measuring rf-range resonance properties of nanoelectromechanical systems (NEMS) with integrated piezoresistive strain detectors serving as signal downmixers. The technique takes advantage of the high strain sensitivity of semiconductor-based piezoresistors, while overcoming the problem of rf signal attenuation due to a high source impedance. Our technique also greatly reduces the effect of the cross-talk between the detector and actuator circuits. We achieve thermomechanical noise detection of cantilever resonance modes up to 71MHz at room temperature, demonstrating that downmixed piezoresistive signal detection is a viable high-sensitivity method of displacement detection in high-frequency NEMS.
Development and Characterization of an Inclined Air-Curtain (IAC) Fume Hood (2015)

An inclined air-curtain (IAC) fume hood was developed and characterized using the laser-assisted smoke flow visualization technique and tracer-gas (sulphur hexafluoride) concentration detection method. The IAC fume hood features four innovative design elements: (i) an elongated suction slot installed at the hood roof with an offset towards the rear wall, (ii) an elongated up-blowing planar jet issued from the work surface near the hood inlet, (iii) two deflection plates installed at the left and right side walls, and (iv) a boundary-layer separation controller installed at the sash bottom. Baffles employed in conventional hoods were not used. The suction slot and the up-blowing planar jet formed a rearward-inclined push-pull air curtain. The deflection plates worked with the inclined air curtain to induce four rearward-inclined counter-rotating 'tornados.' The fumes generated in the hood were isolated behind the rearward-inclined air curtain, entrained by the low pressure within the vortical flows, moved up spirally, and finally exhausted through the suction slot. The risk of containment leakage due to the large recirculation vortex that usually exists behind the sash of conventional hoods was reduced by the boundary-layer separation controller. The results of the tracer-gas concentration detection method based on the EN-14175 method showed that the flow field created by the geometric configurations of the IAC hood presented characteristics of low leakage and high resistance to dynamic disturbances at low face velocities. The leakage levels measured by the static, sash movement, and walk-by tests were negligible at a face velocity of 0.26 m s(-1).
Simulated annealing algorithms: an overview (1989)

A brief introduction is given to the actual mechanics of simulated annealing, and a simple example from an IC layout is used to illustrate how these ideas can be applied. The complexities and tradeoffs involved in attacking a realistically complex design problem are illustrated by dissecting two very different annealing algorithms for VLSI chip floorplanning. Several current research problems aimed at determining more precisely how and why annealing algorithms work are examined. Some philosophical issues raised by the introduction of annealing are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Supplementary Table 1 from Alterations of the Tumor Suppressor Gene <i>ARLTS1</i> in Ovarian Cancer (2023)

Supplementary Table 1 from Alterations of the Tumor Suppressor Gene &lt;i&gt;ARLTS1&lt;/i&gt; in Ovarian Cancer
Task scheduling using intertask dependencies in Carnot (1993)

The Carnot Project at MCC is addressing the problem of logically unifying physically-distributed, enterprise-wide, heterogeneous information. Carnot will provide a user with the means to navigate information efficiently and transparently, to update that information consistently, and to write applications easily for large, heterogeneous, distributed information systems. A prototype has been implemented which provides services for (a) enterprise modeling and model integration to create an enterprise-wide view, (b) semantic expansion of queries on the view to queries on individual resources, and (c) inter-resource consistency management. This paper describes the Carnot approach to transaction processing in environments where heterogeneous, distributed, and autonomous systems are required to coordinate the update of the local information under their control. In this approach, subtransactions are represented as a set of tasks and a set of intertask dependencies that capture the semantics of a particular relaxed transaction model. A scheduler has been implemented which schedules the execution of these tasks in the Carnot environment so that all intertask dependencies are satisfied.
Optimized protocol for multiplex nested polymerase chain reaction to detect and differentiate Haemophilus parasuis, Streptococcus suis, and Mycoplasma hyorhinis in formalin-fixed, paraffin-embedded tissues from pigs with polyserositis. (2012)

An optimized protocol was developed for the simultaneous detection and differentiation of Haemophilus parasuis, Streptococcus suis, and Mycoplasma hyorhinis in formalin-fixed, paraffin-embedded (FFPE) tissues with multiplex nested polymerase chain reaction (PCR). This method also determines the prevalence of these bacteria in pigs with polyserositis. DNA extraction with a combination of a commercial reagent and proteinase K resulted in more frequent detection of the pathogens than DNA extraction with proteinase K alone. Among FFPE tissue samples from 312 cases of polyserositis in which at least 1 bacterial species was detected, multiplex nested PCR detected H. parasuis in 239 (77%), S. suis in 124 (40%), and M. hyorhinis in 40 (13%). The disease was caused by a single pathogen in 224 (72%) of the cases and multiple pathogens in 88 (28%). Among the pigs positive for H. parasuis, S. suis, and M. hyorhinis by multiplex nested PCR, the pathogen was isolated from only 11%, 35%, and 28%, respectively. Therefore, the PCR protocol developed in this study is a useful diagnostic method when samples are negative after isolation methods and even for samples in which only 1 pathogen was isolated.
Voxel-based discriminant map classification on brain ventricles for Alzheimer's disease (2009)

One major hallmark of the Alzheimer's disease (AD) is the loss of neurons in the brain. In many cases, medical experts use magnetic resonance imaging (MRI) to qualitatively measure the neuronal loss by the shrinkage or enlargement of the structures-of-interest. Brain ventricle is one of the popular choices. It is easily detectable in clinical MR images due to the high contrast of the cerebro-spinal fluid (CSF) with the rest of the parenchyma. Moreover, atrophy in any periventricular structure will directly lead to ventricle enlargement. For quantitative analysis, volume is the common choice. However, volume is a gross measure and it cannot capture the entire complexity of the anatomical shape. Since most existing shape descriptors are complex and difficult-to-reproduce, more straightforward and robust ways to extract ventricle shape features are preferred in the diagnosis. In this paper, a novel ventricle shape based classification method for Alzheimer's disease has been proposed. Training process is carried out to generate two probability maps for two training classes: healthy controls (HC) and AD patients. By subtracting the HC probability map from the AD probability map, we get a 3D ventricle discriminant map. Then a matching coefficient has been calculated between each training subject and the discriminant map. An adjustable cut-off point of the matching coefficients has been drawn for the two classes. Generally, the higher the cut-off point that has been drawn, the higher specificity can be achieved. However, it will result in relatively lower sensitivity and vice versa. The benchmarked results against volume based classification show that the area under the ROC curves for our proposed method is as high as 0.86 compared with only 0.71 for volume based classification method.
Kunststoffe im Vergleich (2022)

No AccessSaechtling Kunststoff-HandbuchOct 2022Kunststoffe im VergleichErwin Baur, Dietmar Drummer, Tim A. Osswald, Natalie RudolphErwin Baur, Dietmar Drummer, Tim A. Osswald, Natalie Rudolphhttps://doi.org/10.3139/9783446473614.008SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2022Pages: 803-849Print ISBN: 978-3-446-46514-5eISBN: 978-3-446-47361-4 Copyright & Permissions© 2022 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
Linear Technique for Discrimination of Optically Coded Waveforms Using Optical Frequency Combs (2012)

We have demonstrated a novel coherent optical detection architecture that serves as a matched filter and successfully discriminates between various encoded optical waveforms with high confidence. The waveforms are produced by encoding the spectral phase of an optical frequency comb with codes from a Walsh-Hadamard set. The encoded optical waveforms are decoded with a coherent detection technique implemented using an optical frequency comb as a set of local oscillators, an interferometer, and a pair of differential balanced photodetectors. The use of only linear optical devices in the receiver results in a higher sensitivity compared to the use of nonlinear optical thresholding and gating techniques. Decoding is demonstrated at power levels of ~ 25 μW, which are much lower than previously reported. Possible applications of the receiver architecture include laser radar and optical communications in an optical code-division multiple access network.
Validation of SCT Methylation as a Hallmark Biomarker for Lung Cancers (2015)

Our findings demonstrated that SCT methylation is a highly discriminative biomarker for lung and other malignant tumors, is less frequent in low-grade malignant tumors (including lung carcinoids), and appears at the carcinoma in situ stage.
Measurement of the relative rate of prompt χ c0, χ c1 and χ c2 production at $ \sqrt{s}=7 $ TeV (2013)

A bstract Prompt production of charmonium χ c 0 , χ c 1 and χ c 2 mesons is studied using proton-proton collisions at the LHC at a centre-of-mass energy of $ \sqrt{s}=7 $ TeV. The χ c mesons are identified through their decay to J/ ψγ, with J/ ψ → μ + μ − using photons that converted in the detector. A data sample, corresponding to an integrated luminosity of 1.0 fb −1 collected by the LHCb detector, is used to measure the relative prompt production rate of χ c 1 and χ c 2 in the rapidity range 2 . 0 &lt; y &lt; 4 . 5 as a function of the J/ ψ transverse momentum from 3 to 20 GeV /c . First evidence for χ c 0 meson production at a high-energy hadron collider is also presented.