gebhart/patrepeval huggingface dataset:
Negative-tone Photodefinable Underfill Having High Resolution and Appropriate Thermal Fluidity (2017)

Photodefinable wafer level underfill (PWLUF) has been evaluated for chip to substrate stacking. The good fluidity of PWLUF after patterning is required for chip and substrate stacking. PWLUF was designed using polyimide, acrylates, epoxides and some additives. It was difficult to improve the fluidity of patterned PWLUF keeping resolution by changing the composition ratio of acrylates and epoxides. On the other hand, PWLUF using the polyimide oligomer obtained by increasing end capping agent ratio improved the fluidity as well as the resolution. The chip to substrate stacks afford void-free bump soldering without underfill entrapment. We also successfully demonstrated the reflow soldering process using PWLUF.
Inhibition of Sirtuin 2 with Sulfobenzoic Acid Derivative AK1 is Non-Toxic and Potentially Neuroprotective in a Mouse Model of Frontotemporal Dementia (2012)

Tauopathies including tau-associated Frontotemporal dementia (FTD) and Alzheimer's disease are characterized pathologically by the formation of tau-containing neurofibrillary aggregates and neuronal loss, which contribute to cognitive decline. There are currently no effective treatments to prevent or slow this neural systems failure. The rTg4510 mouse model, which expresses a mutant form of the tau protein associated with FTD with Parkinsonism-17, undergoes dramatic hippocampal and cortical neuronal loss making it an ideal model to study treatments for FTD-related neuronal loss. Sirtuins are a family of proteins involved in cell survival that have the potential to modulate neuronal loss in neurodegenerative disorders. Here we tested the hypothesis that sirtuin 2 (SIRT2) inhibition would be non-toxic and prevent neurodegeneration in rTg4510 brain. In this study we delivered SIRT2 inhibitor AK1 directly to the hippocampus with an osmotic minipump and confirmed that it reached the target region both with histological assessment of delivery of a dye and with a pharmacodynamic marker, ABCA1 transcription, which was upregulated with AK1 treatment. AK1 treatment was found to be safe in wild-type mice and in the rTg4510 mouse model, and further, it provided some neuroprotection in the rTg4510 hippocampal circuitry. This study provides proof-of-concept for therapeutic benefits of SIRT2 inhibitors in both tau-associated FTD and Alzheimer's disease, and suggests that development of potent, brain permeable SIRT2 inhibitors is warranted.
Analysis of Dilatant Behavior of Cosmetic Slurries Formed by Mica Powders (2013)

Dilatant behavior of slurries formed by cosmetic powders was analyzed by the rhelogical analysis. The slurry formed by sericite shows dilatant flow at large strain range. In case of sericite slurry, the storage modulus was larger than the loss modulus even when the strain of one hundred percent was added. Flowability depending on the thickness of synthetic micas tended to show dilatant behavior.The reason why the cosmetic slurries showed dilatant behavior was considered that the affinity between these powders in a solution was weaker than the one between ordinal mica powders. The weak affinity of sericite and synthetic micas brought viscoelastic characters. Consequently, it was considered that they could not be easily molded. To get rid of the difficulty in molding, surface treatment of powder were found to be effective. When the surface of sericite was thickly coated by silicone, reduction of the dilatancy was the most significant.
Multiple 6-Bromotryptophan Residues in a Sleep-Inducing Peptide (2004)

We have characterized a novel sleep-inducing peptide comprising 33 amino acids with three residues of the unusual posttranslationally modified amino acid, 6-bromotryptophan. The peptide, termed "light sleeper" or the r7a conotoxin, was purified from the venom of the fish-hunting Conus radiatus. The light sleeper peptide has additional notable biochemical properties; it equilibrates slowly between two distinct conformers, and has four gamma-carboxyglutamate residues. The pattern of posttranslational bromination in the light sleeper peptide suggests that tryptophan residues at N- and C-termini may be preferential sites for posttranslational bromination.
Hyperammonemia alters the modulation by different neurosteroids of the glutamate–nitric oxide–cyclic GMP pathway through NMDA‐ GABAA‐ or sigma receptors in cerebellumin vivo (2012)

Several neurosteroids modulate the glutamate-nitric oxide (NO)-cGMP pathway in cerebellum through modulation of NMDA- GABAA - or sigma receptors. Hyperammonemia alters the concentration of several neurosteroids and impairs the glutamate-NO-cGMP pathway, leading to impaired learning ability. This work aimed to assess whether chronic hyperammonemia alters the modulation by different neurosteroids of GABAA, NMDA, and/or sigma receptors and of the glutamate-NO-cGMP pathway in cerebellum. Neurosteroids were administered through microdialysis probes, and extracellular cGMP and citrulline were measured. Then NMDA was administered to assess the effects on the glutamate-NO-cGMP pathway activation. Hyperammonemia completely modifies the effects of pregnanolone and pregnenolone. Pregnanolone acts as a GABAA receptor agonist in controls, but as an NMDA receptor antagonist in hyperammonemic rats. Pregnenolone does not induce any effect in controls, but acts as a sigma receptor agonist in hyperammonemic rats. Hyperammonemia potentiates the actions of tetrahydrodeoxy-corticosterone (THDOC) as a GABAA receptor agonist, allopregnanolone as an NMDA receptor antagonist, and pregnenolone sulfate as an NMDA receptor activation enhancer. Neurosteroids that reduce the pathway (pregnanolone, THDOC, allopregnanolone, DHEAS) may contribute to cognitive impairment in hyperammonemia and hepatic encephalopathy. Pregnenolone would impair cognitive function in hyperammonemia. Neurosteroids that restore the pathway in hyperammonemia (pregnenolone sulfate) could restore cognitive function in hyperammonemia and encephalopathy.
Abnormal axon guidance signals and reduced interhemispheric connection via anterior commissure in neonates of marmoset ASD model (2019)

In autism spectrum disorder (ASD), disrupted functional and structural connectivity in the social brain has been suggested as the core biological mechanism underlying the social recognition deficits of this neurodevelopmental disorder. In this study, we aimed to identify genetic and neurostructural abnormalities at birth in a non-human primate model of ASD, the common marmoset with maternal exposure to valproic acid (VPA), which has been reported to display social recognition deficit in adulthood. Using a comprehensive gene expression analysis, we found that 20 genes were significantly downregulated in VPA-exposed neonates. Of these, Frizzled3 (FZD3) and PIK3CA were identified in an axon guidance signaling pathway. FZD3 is essential for the normal development of the anterior commissure (AC) and corpus callosum (CC); hence, we performed diffusion tensor magnetic resonance imaging with a 7-Tesla scanner to measure the midsagittal sizes of these structures. We found that the AC size in VPA-exposed neonates was significantly smaller than that in age-matched controls, while the CC size did not differ. These results suggest that downregulation of the genes related to axon guidance and decreased AC size in neonatal primates may be linked to social brain dysfunctions that can happen later in life.
ChemInform Abstract: SILICON‐DIRECTED NAZAROV REACTIONS. III. STEREOCHEMICAL AND MECHANISTIC CONSIDERATIONS (1984)

Abstract Anhand der Cyclisierung der silylsubstituierten Divinylketone (I) zu den cis‐Hexahydroind‐2‐en‐1‐onen (II) und (III) (ca 3:1) werden der Einfluß der Substituenten R 1 ‐R 4 auf den Ringbildungsprozeß, die Natur der Zwischenprodukte und die Gründe für die einzigartige Fähigkeit von Fe‐trichlorid, diese Cyclisierung zu induzieren, diskutiert.
A retransmission scheme for circuit-mode data on wireless links (2002)

The cellular radio link is characterized by deep fades leading to long error bursts (lasting hundreds of msec). Data transmission over such links results in large packet error rates (in the range 10/sup -3/ to 10/sup -1/). The authors have designed a radio link protocol (RLP) to achieve high throughput on such links. The RLP is based on frequent, complete or partial feedback of the receiver state. Performance results for the US digital cellular TDMA standard show that the scheme can provide the equivalent of 9.6 kbps service per full-rate TDMA channel above a carrier to interference ratio of 18 dB.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Flow environment and matrix structure interact to determine spatial competition in Pseudomonas aeruginosa biofilms (2017)

Bacteria often live in biofilms, which are microbial communities surrounded by a secreted extracellular matrix. Here, we demonstrate that hydrodynamic flow and matrix organization interact to shape competitive dynamics in <i>Pseudomonas aeruginosa</i> biofilms. Irrespective of initial frequency, in competition with matrix mutants, wild-type cells always increase in relative abundance in planar microfluidic devices under simple flow regimes. By contrast, in microenvironments with complex, irregular flow profiles - which are common in natural environments - wild-type matrix-producing and isogenic non-producing strains can coexist. This result stems from local obstruction of flow by wild-type matrix producers, which generates regions of near-zero shear that allow matrix mutants to locally accumulate. Our findings connect the evolutionary stability of matrix production with the hydrodynamics and spatial structure of the surrounding environment, providing a potential explanation for the variation in biofilm matrix secretion observed among bacteria in natural environments.
Measurement of cell motility and morphology with an automated microscope system (1988)

A method is presented which provides quantitative descriptions of the morphology and motility behaviour of a large number of unperturbed individual cells. For that, a microscope system has been developed that performs automated tracking of motile mammalian cells in tissue culture and the concurrent measurement of cell morphology. Experiments using 3T3 mouse fibroblasts show that simple global morphological features, such as degree of cell elongation, correlate with the motile behaviour of individual cells. Combined data from many cells following trypsinization and replating show the time course of the spreading of cells, measured by increase in average cell area, and the onset of cell polarization, measured by change in average cell circularity. Methods for describing fibroblast morphology and changes in morphology are discussed.
Compartmentalization and Trafficking in Endoplasmic Reticulum Protein Quality Control (2023)

Following translocation into the rough endoplasmic reticulum (ER), secretory proteins undergo a series of folding, maturation, compartmentalization and trafficking events. These are finely tuned to avoid misfolded protein accumulation and the consequent ER stress. Misfolded proteins and components of the ER quality control and ER-associated degradation (ERAD) machineries concentrate in mammalian cells in the pericentriolar ER-derived quality control compartment (ERQC), a staging ground for ERAD. We have recently determined that, surprisingly, trafficking to the ERQC and delivery to ERAD are dependent on COPII-coated vesicle transport and that they can be retrieved to the peripheral ER in COPI-coated vesicles.
The Modern Strategy for Cardiogenic Shock (2003)

Although emergency cardiac care resources are oriented toward rapid implementation of reperfusion therapy with resultant myocardial salvage and improvement in survival, cardiogenic shock remains the leading cause of death among hospitalized patients with acute myocardial infarction (Fig. 1) (1–5).
Configurations of Modified SEPIC Converter with Switched Inductor Module (MSCsI) for Photovoltaic Application: Part-II (2018)

The proposed work is extended configurations of Modified SEPIC Converter (MSC) and Modified SEPIC Converter with Switched Module (MSC <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">SI</sub> ). The proposed three configurations are derived by replacing two inductor of MSC by two Switched Inductor (SI) modules, namely Modified SEPIC Converter with XYL configuration (MSC <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">SI</sub> -XYL), Modified SEPIC Converter with LYZ configuration (MSC <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">SI</sub> -LYZ) and Modified SEPIC Converter with XLZ configuration (MSC <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">SI</sub> -XLZ) to improve or increase the overall gain of the converter. The key feature of proposed configuration is: (i) single switch topologies, (ii) no reverse current flow from load to source due to large inductor at the input side, (iii) high voltage conversion ratio. The detailed analysis of three configurations is done in terms of component count, voltage conversion ratio and efficiency. The mathematical analysis and simulation results validates the functionality of three configurations.
One, two, three—p53, p63, p73 and chemosensitivity (2006)

Molecular links between apoptosis, tumorigenesis and drug resistance provide starting points for new therapeutic approaches and for a targeted cancer therapy. The discovery of the p53-related genes p63 and p73 raised the possibility that they may be cancer-associated genes and as a consequence that p53 is not the only component in predicting prognosis and response to chemotherapy, but instead the status of a network that contains p53, p73 and p63. This review focuses on the status and interrelationship of the p53 family members in human cancer as critical elements for tumor progression and response to therapy. Literature up to December 2006 is reviewed. p63 and p73--as well as p53--each use multiple promoters and alternative splicing to generate an array of isoforms, including full-length isoforms with a transactivation (TA-) domain homologous to that of full-length p53, and amino-terminally truncated (DeltaN-) isoforms. Whereas the full-length TA isoforms of p63 and p73 can activate downstream target genes and induce apoptosis, the DeltaN isoforms which lack the transactivation domain can act as dominant inhibitors of the full-length forms of p53, p63 and p73, inhibiting transactivation of target genes and induction of apoptosis. Deregulated dominant negative p63 and p73 isoforms play an oncogenic role in human cancer and contribute to chemoresistance. Thus, therapeutic modulation of TAp63/DeltaNp63, TAp73/DeltaNp73 and mutant p53 levels might be used to target the large percentage of human tumors that harbor p53 mutations and/or overexpress DeltaNp63 or DeltaNp73. Interfering with the expression or function of DeltaNp63 and/or DeltaNp73 and/or mutant p53 in tumor cells may render such tumors more responsive to therapy and reduce their aggressiveness and metastatic capacity.
The chemical biology of IL-12 production via the non-canonical NFkB pathway (2020)

Interleukin-12 (IL-12) has emerged as an attractive cytokine for cancer therapy because it has direct anti-cancer effects and additionally plays a critical role in enhancing checkpoint inhibitors. Given these multiple modes of actions, identifying means to pharmacologically induce IL-12 production in the tumor microenvironment has become important. In this review, we highlight therapeutics that promote IL-12 induction in tumor-associated myeloid cells through the non-canonical NFkB pathway. We discuss existing clinical trials and briefly examine the additional pathway targets that warrant further exploration for drug discovery.
Self Correspondence Distillation for End-to-End Weakly-Supervised Semantic Segmentation (2023)

Efficiently training accurate deep models for weakly supervised semantic segmentation (WSSS) with image-level labels is challenging and important. Recently, end-to-end WSSS methods have become the focus of research due to their high training efficiency. However, current methods suffer from insufficient extraction of comprehensive semantic information, resulting in low-quality pseudo-labels and sub-optimal solutions for end-to-end WSSS. To this end, we propose a simple and novel Self Correspondence Distillation (SCD) method to refine pseudo-labels without introducing external supervision. Our SCD enables the network to utilize feature correspondence derived from itself as a distillation target, which can enhance the network's feature learning process by complementing semantic information. In addition, to further improve the segmentation accuracy, we design a Variation-aware Refine Module to enhance the local consistency of pseudo-labels by computing pixel-level variation. Finally, we present an efficient end-to-end Transformer-based framework (TSCD) via SCD and Variation-aware Refine Module for the accurate WSSS task. Extensive experiments on the PASCAL VOC 2012 and MS COCO 2014 datasets demonstrate that our method significantly outperforms other state-of-the-art methods. Our code is available at https://github.com/Rongtao-Xu/RepresentationLearning/tree/main/SCD-AAAI2023.
IL-1α is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity (2015)

Environmental signals can be translated into chromatin changes, which alter gene expression. Here we report a novel concept that cells can signal chromatin damage from the nucleus back to the surrounding tissue through the cytokine interleukin-1alpha (IL-1α). Thus, in addition to its role as a danger signal, which occurs when the cytokine is passively released by cell necrosis, IL-1α could directly sense DNA damage and act as signal for genotoxic stress without loss of cell integrity. Here we demonstrate localization of the cytokine to DNA-damage sites and its subsequent secretion. Interestingly, its nucleo-cytosolic shuttling after DNA damage sensing is regulated by histone deacetylases (HDAC) and IL-1α acetylation. To demonstrate the physiological significance of this newly discovered mechanism, we used IL-1α knockout mice and show that IL-1α signaling after UV skin irradiation and DNA damage is important for triggering a sterile inflammatory cascade in vivo that contributes to efficient tissue repair and wound healing.
A bibliography of higher-order spectra and cumulants (1994)

The interest in higher-order spectra and cumulants was renewed in the early 1980s due, in part, to the need to solve detection, estimation, and identification problems when the interfering noise source was non-Gaussian. The bibliography is a list of refereed journal papers. An effort was made to include all relevant papers, though the focus of the search was the IEEE journals, the optics journals, and the statistical journals. The bibliography is intended to be a research tool. Tutorials detail discussions of higher-order spectra and cumulants, and books cover the more advanced topics.
Cryopreservation of virulent Acinetobacter baumannii to reduce variability of in vivo studies (2015)

Frozen stocks require considerably less time to prepare and enhance reproducibility of in vivo experimental results when infecting with A. baumannii.
Myelomastocytic Leukemia: Evidence for the Origin of Mast Cells from the Leukemic Clone and Eradication by Allogeneic Stem Cell Transplantation (2005)

These data suggest that mast cells directly derive from the leukemic clone in patients with myelomastocytic leukemia.
Directed Self-Assembly of Silicon-Containing Block Copolymer Thin Films (2015)

The directed self-assembly (DSA) of lamella-forming poly(styrene-block-trimethylsilylstyrene) (PS-PTMSS, L0=22 nm) was achieved using a combination of tailored top interfaces and lithographically defined patterned substrates. Chemo- and grapho-epitaxy, using hydrogen silsesquioxane (HSQ) based prepatterns, achieved density multiplications up to 6× and trench space subdivisions up to 7×, respectively. These results establish the compatibility of DSA techniques with a high etch contrast, Si-containing BCP that requires a top coat neutral layer to enable orientation.
Superexchange-pathway model for long-distance electronic couplings (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSuperexchange-pathway model for long-distance electronic couplingsConrad A. Naleway, Larry A. Curtiss, and John R. MillerCite this: J. Phys. Chem. 1991, 95, 22, 8434–8437Publication Date (Print):October 1, 1991Publication History Published online1 May 2002Published inissue 1 October 1991https://pubs.acs.org/doi/10.1021/j100175a005https://doi.org/10.1021/j100175a005research-articleACS PublicationsRequest reuse permissionsArticle Views550Altmetric-Citations119LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Metal/molecule/p-type GaAs heterostructure devices (2006)

Molecular devices in a metal/molecule/p-type GaAs configuration were fabricated, electrically characterized, and analyzed using an electrostatic model. Various alkane and aromaticthiols were self-assembled on GaAs substrates and the top metal contact was formed by a low energy, indirect path technique. Spectroscopic and surface characterization results indicate the formation of a nonpenetrative, robust metal contact on smooth, uniform, and crystalline monolayers. Molecular devices with a Au top contact exhibit increased conductivity and less rectification than the control Schottky devices. The observed temperature and voltage dependence of the current is consistent with direct tunneling transport in the case of all the molecular samples. An electrostatic model which considers the dielectric constant and dipole charge of the molecular layer has been developed to estimate the GaAs depletion barrier at the molecule-GaAs interface. A semiquantitative model has been developed for device conductivity, which assumes that the conductivity is proportional to the product of the molecular density of states and the strength of molecular coupling to the GaAs contact. It uses an analytical thermionic-field emission model for the semiconductor depletion barrier to estimate the strength of molecular coupling to the GaAs contact. The relative conductances of the molecules, after accounting for the effects of the semiconductor portion of the barrier, are in line with reported values for the densities of states of the molecules and calculated conductances for corresponding metal-molecule-metal devices.