gebhart/patrepeval huggingface dataset:
In Vivo gp41 Antibodies Targeting the 2F5 Monoclonal Antibody Epitope Mediate Human Immunodeficiency Virus Type 1 Neutralization Breadth (2009)

The broadly neutralizing human monoclonal antibodies (MAbs) 2F5 and 4E10, both targeting the highly conserved human immunodeficiency virus type 1 (HIV-1) envelope membrane proximal external region (MPER), are among the MAbs with the broadest heterologous neutralizing activity and are of considerable interest for HIV-1 vaccine development. We have identified serum antibodies from an HIV-infected subject that both were broadly neutralizing and specifically targeted MPER epitopes that overlap the 2F5 epitope. These MPER-specific antibodies were made 15 to 20 months following transmission and concomitantly with the development of autoantibodies. Our findings suggest that multiple events (i.e., genetic predisposition and HIV-1 immune dysregulation) may be required for induction of broadly reactive gp41 MPER antibodies in natural infection.
All-Optical Modulation Format Conversion from NRZ-OOK to RZ-QPSK Using Integrated SOA Three-Arm-MZI Wavelength Converter (2009)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text S. M. Nissanka, A. Maruta, S. Mitani, K. Shimizu, T. Miyahara, T. Aoyagi, T. Hatta, A. Sugitatsu, and K. Kitayama, "All-Optical Modulation Format Conversion from NRZ-OOK to RZ-QPSK Using Integrated SOA Three-Arm-MZI Wavelength Converter," in Optical Fiber Communication Conference and National Fiber Optic Engineers Conference, OSA Technical Digest (CD) (Optica Publishing Group, 2009), paper OThM5. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Abstract 3825: Targeting activated PI3K/mTOR signaling overcomes resistance to CDK4/6-based therapies in preclinical ER+ breast cancer models (2019)

Addition of CDK4/6 inhibitors such as palbociclib, ribociclib or abemaciclib to endocrine-based therapies significantly improves progression-free and in some subgroups, overall survival in patients with advanced estrogen receptor-positive (ER+) breast cancer. However, acquired resistance to CDK4/6 inhibitors remains a significant unmet clinical need. It is critical to ascertain the mechanisms by which tumor cells evade CDK4/6 based therapy. In this study we screen multiple in vitro and in vivo models of acquired resistance to CDK4/6 inhibitors to identify potential resistance/escape pathways and targets for pharmaceutical intervention to overcome resistance. ER+ breast cancer cell lines of diverse molecular backgrounds were conditioned to acquire resistance to CDK4/6 inhibitors through either long-term culture in the presence of clinically relevant concentrations of inhibitors or as cell line xenografts treated through progression on a CDK4/6 inhibitor plus fulvestrant. Baseline and pharmacodynamic changes in cell signaling were measured using reverse phase protein array (RPPA) and RNAseq analysis. Acquired resistance to CDK4/6 inhibitors was associated with decreases in phosphorylated-Rb (pRb) and ER-alpha protein and increases in pAKT and pS6 relative to isogenic controls. The p110α-selective PI3K-inhibitor, alpelisib, in combination with fulvestrant or ribociclib/fulvestrant blocked pAKT signaling in xenografts progressing on palbociclib/fulvestrant and induced significant tumor regressions. Apelisib plus fulvestrant also produced robust anti-tumor responses in xenografts progressing on ribociclib/fulvestrant. Triple combination treatment with ribociclib/alpelisib/fulvestrant induced significant regressions in resistant tumors and in treatment naïve models, where complete tumor regressions occurred regardless of PIK3CA mutation status. Regressions were maintained for >9 weeks post withdrawal of treatment, indicating that therapeutic resistance may be prevented by this triple combination approach. RPPA analysis of responding tumors identified sustained inhibition of both PI3K- and CDK4/6:Rb-pathway signaling accompanied by activation of pro-apoptotic proteins. These data support clinical investigation of targeting PI3K with alpelisib in breast cancers progressing on CDK4/6 based therapies and investigation of upfront triple combination therapy prior to acquisition of resistance to CDK4/6.Citation Format: Neil A. O'Brien, Martina SJ McDermott, Dylan F. Conklin, Alex Gaither, Tong Luo, Raul Ayala, Suruchi Salgar, Emmanuelle DiTomaso, Naveen Babbar, Faye Su, Sara A. Hurvitz, Ronald Linnartz, Kristine Rose, Samit Hirawat, Dennis J. Slamon. Targeting activated PI3K/mTOR signaling overcomes resistance to CDK4/6-based therapies in preclinical ER+ breast cancer models [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3825.
Sequential increases in 4F2hc expression during DMBA-induced hamster buccal pouch carcinogenesis. (2004)

The results suggest that 4F2hc expression is associated with the development of DMBA-induced oral carcinomas. In addition, 4F2hc overexpression in SCC indicates that 4F2hc may play an important role in the development and progression of oral SCC.
Effect of xanthan gum on enhancing the foaming properties of soy protein isolate (1998)

Abstract The foaming properties of soy protein isolate (SPI) in the presence of xanthan gum (XG) were investigated. The XG solution alone did not exhibit any foaming ability. The optimal foaming properties were obtained from the SPI‐XG dispersion that contained 0.1% SPI and 0.2% XG. This SPI‐XG dispersion gave higher foaming capacity than that of SPI or egg white ( P &lt;0.05). The foam stability of SPI‐XG dispersion was nine times higher than that of SPI and egg white ( P &lt;0.05). The SPI‐XG foams were stable over wide ranges of ionic strength (0.1 to 1.0 M NaCl) and pH (4.5 to 9.0), and when heated (85°C, 1 h).
Cascadability study of dispersion-compensated interleaver pairs for metro add/drop applications using a re-circulating loop (2005)

A cascadability study is performed, using a re-circulating loop, of a 50-GHz-spaced dispersion-compensated interleaver pair. After five cascaded nodes, a 2.5-dB sensitivity differential is observed with /spl plusmn/0.07 nm wavelength detuning for with/without dispersion compensation pair.
TARGETING THE CYTOPROTECTIVE CHAPERONE CLUSTERIN AS A STRATEGY TO INCREASE THE ANTICANCER ACTIVITY OF THE HSP90 INHIBITOR 17-ALLYLAMINO-DEMETHOXY GELDANAMYCIN (2008)

You have accessJournal of Urology1 Apr 2008TARGETING THE CYTOPROTECTIVE CHAPERONE CLUSTERIN AS A STRATEGY TO INCREASE THE ANTICANCER ACTIVITY OF THE HSP90 INHIBITOR 17-ALLYLAMINO-DEMETHOXY GELDANAMYCIN Amina Zoubeidi, Eliana Beraldi, Yen TN Nguyen, and Martin E Gleave Amina ZoubeidiAmina Zoubeidi More articles by this author , Eliana BeraldiEliana Beraldi More articles by this author , Yen TN NguyenYen TN Nguyen More articles by this author , and Martin E GleaveMartin E Gleave More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(08)60648-5AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "TARGETING THE CYTOPROTECTIVE CHAPERONE CLUSTERIN AS A STRATEGY TO INCREASE THE ANTICANCER ACTIVITY OF THE HSP90 INHIBITOR 17-ALLYLAMINO-DEMETHOXY GELDANAMYCIN." The Journal of Urology, 179(4S), p. 225 © 2008 by American Urological AssociationFiguresReferencesRelatedDetails Volume 179Issue 4SApril 2008Page: 225 Advertisement Copyright & Permissions© 2008 by American Urological AssociationMetricsAuthor Information Amina Zoubeidi More articles by this author Eliana Beraldi More articles by this author Yen TN Nguyen More articles by this author Martin E Gleave More articles by this author Expand All Advertisement PDF downloadLoading ...
Invasive Pneumococcal Disease in Solid Organ Transplant Recipients—10-Year Prospective Population Surveillance (2007)

Prospective population-based surveillance to assess the incidence and impact of invasive pneumococcal disease (IPD) in organ transplant patients is lacking. By using a population-based Invasive Bacterial Diseases Network surveillance program, we studied the incidence, clinical significance, serotypes and antimicrobial resistance pattern of IPD in a large cohort of adult transplant patients and the general population. Streptococcus pneumoniae isolates and patient data were collected prospectively from 1995 to 2004. We identified 21 cases of IPD (based on sterile-site isolates) in our organ transplant population over a 10-year period. This translated to an incidence rate of 146 infections per 100,000 persons per year. This compared to an incidence of 11.5 per 100,000 persons per year in the general population (R(R)=12.8; 95% CI 8.1-19.9, p<0.00001). If nonsterile-site isolates (respiratory tract) were included, the incidence rate in transplant patients was 419 of 100 000 persons per year. Serotypes 23F and 22F were most common, and 85.0% had a serotype included in the 23-valent pneumococcal vaccine. The antimicrobial resistance rates were high, especially for penicillin and trimethoprim-sulfamethoxazole (TMP/SMX), but were not significantly different from the general population. Solid organ transplant recipients are at significantly greater risk for IPD than the general population. Preventative strategies are necessary.
Optimization for Production of Exo-β-1,3-glucanase (Laminarinase) from Aspergillus oryzae in Saccharomyces cerevisiae (2011)

In this study, a EXGA gene code for exo-&#x03B2;-1,3-glucanase from Aspergillus oryzae was overexpressed and secretory produced in Saccharomyces cerevisiae. To overexpress the &#x03B2;-1,3-glucanase, pGInu-exgA and pAInu-exgA plasmids having GAL10 and ADH1 promoter, respectively, and exoinulinase signal sequence (Inu s.s) were constructed and introduced in S. cerevisiae SEY2102 and 2805. The recombinant &#x03B2;-1,3-glucanase was successfully expressed and secreted into the medium and the &#x03B2;--1,3-glucanase activity in 2102/pGInu-exgA and 2102/pAInu-exgA strain were 5.01 unit/mL and 4.09 unit/mL, respectively. In the 2805/pGInu-exgA and 2805/pAInu-exgA strain, the &#x03B2;-1,3-glucanase activity showed 3.23 unit/mL and 3.22 unit/mL, respectively. Secretory efficiency in each strain reached 95% to 98%. Subsequently, the recombinant &#x03B2;1,3-glucanase was used for ethanol production. Ethanol productivity in 2102/pAInu-exgA strain was 0.83 g/L when pre-treated Laminaria japonica which has initial reducing sugar of 1.4 g/L was used as substrate. It is assumed that the polysaccharides of Laminaria japonica was effectively saccharified by recombinant &#x03B2;-1,3-glucanase, resulting in increase of ethanol productivity. These results suggested that recombinant &#x03B2;-1,3-glucanase was efficiently overexpressed and secreted in S. cerevisiae SEY2102 as host strain by using ADH1 promoter-Inu s.s system.
Automated Stateful Protocol Verification (2020)

In protocol verification we observe a wide spectrum from fully automated methods to interactive theorem proving with proof assistants like Isabelle/HOL. In this AFP entry, we present a fully-automated approach for verifying stateful security protocols, i.e., protocols with mutable state that may span several sessions. The approach supports reachability goals like secrecy and authentication. We also include a simple user-friendly transaction-based protocol specification language that is embedded into Isabelle.
Coupling waveguide array for a patch array calibration scanner (2010)

This document presents the developmentof novel coupling devices for the verification and the calibration of each patch element in a largew patch array antenna. Different options have been compared. This results in an array of waveguides with an integrated planar circuit board feed.
Premalbrancheamide: Synthesis, Isotopic Labeling, Biosynthetic Incorporation, and Detection in Cultures of Malbranchea aurantiaca (2008)

An advanced metabolite, named premalbrancheamide, involved in the biosynthesis of malbrancheamide (1) and malbrancheamide B (2) has been synthesized in double (13)C-labeled form and was incorporated into the indole alkaloid 2 by Malbranchea aurantiaca. In addition, premalbrancheamide has been detected as a natural metabolite in cultures of M. aurantiaca. The biosynthetic implications of these experiments are discussed.
Ion bombardment effects in the sputtering of single‐ and two‐phase brass alloys; Cu: 18–48% Zn (1987)

Abstract The effect of ion bombardment on the near‐surface composition of brass has been investigated over a bulk composition range including single‐phase α (fcc) brass and two‐phase, α + β (bcc) brass. Auger electron spectroscopy has been used to determine the equilibrium near‐surface composition after ion sputtering with argon and xenon at ion energies between 1 and 4 keV. Preferential removal of the zinc was found under all conditions. X‐ray photoelectron spectroscopy has been used to investigate variations in composition in the first atomic layers by comparison of the intensities and escape depths of the 2p and 3p photoemission peaks. The near‐surface composition was primarily a function of ion energy in the single α phase, with higher ion energy increasing the preferential removal of zinc; no change was detected comparing data from information depths of 5 vs. 10 monolayers. In the mixed α + β phase, surface zinc concentration decreased with increasing ion energy and mass, and depletion of zinc was greater nearer to the surface.
A Case Study of Truncated Electrostatics for Simulation of Polyelectrolyte Brushes on GPU Accelerators (2012)

Numerous issues have disrupted the trend for increasing computational performance with faster CPU clock frequencies. In order to exploit the potential performance of new computers, it is becoming increasingly desirable to re-evaluate computational physics methods and models with an eye toward approaches that allow for increased concurrency and data locality. The evaluation of long-range Coulombic interactions is a common bottleneck for molecular dynamics simulations. Enhanced truncation approaches have been proposed as an alternative method and are particularly well-suited for many-core architectures and GPUs due to the inherent fine-grain parallelism that can be exploited. In this paper, we compare efficient truncation-based approximations to evaluation of electrostatic forces with the more traditional particle-particle particle-mesh (P(3)M) method for the molecular dynamics simulation of polyelectrolyte brush layers. We show that with the use of GPU accelerators, large parallel simulations using P(3)M can be greater than 3 times faster due to a reduction in the mesh-size required. Alternatively, using a truncation-based scheme can improve performance even further. This approach can be up to 3.9 times faster than GPU-accelerated P(3)M for many polymer systems and results in accurate calculation of shear velocities and disjoining pressures for brush layers. For configurations with highly nonuniform charge distributions, however, we find that it is more efficient to use P(3)M; for these systems, computationally efficient parametrizations of the truncation-based approach do not produce accurate counterion density profiles or brush morphologies.
Meniscectomized Knees Regain Normal Walking Flexion Range of Motion With Time Past Surgery (2013)

Meniscal tears are one of the most common knee injuries with an incidence rate of 60–70 per 100,000 person-years [1]. Although arthroscopic partial meniscectomy, the leading treatment for meniscal tears, decreases pain, the risk of knee osteoarthritis (OA) is four times higher for a meniscectomized knee compared to an uninjured knee [2]. Prior research has shown that meniscectomized knees have reduced sagittal-plane range of motion in the early period following surgery (6 to 18 months) [3–5]. These observations suggest a mechanical pathway to knee OA, in which alteration in ambulatory knee function causes shifts in tibiofemoral cartilage location to unprepared cartilage regions, thus causing damage to the maladapted tissue [6]. While such a mechanical pathway is well documented for knees with reconstruction of the anterior cruciate ligament [7], the paucity of information regarding the walking mechanics of meniscectomized knees at longer term post-operation limits our understanding of the pathway to OA in this population. Particularly, it is unknown whether meniscectomized knees regain normal dynamic range of motion (ROM) in knee flexion with time past surgery. Because regaining ROM alters the mechanical function in the meniscectomized knee, understanding the changes in this gait variable over time may help elucidate the various pathways to OA development in meniscectomized knees.
Synthesis and characterization of a new biodegradable semi-solid poly(ortho ester) for drug delivery systems (1993)

Since the late 1970s, three families of poly(ortho esters) (POE) were synthesized to provide bioerodible carriers for drug delivery devices. The most recent POE is a semi-solid polymer with a viscous behavior at room temperature. Polymer synthesis by a transesterification reaction between a triol and a trialkyl ortho ester is described. The structure of the polymer was confirmed by conventional methods such as 1H-NMR, 13C-NMR and FT-IR. Information concerning average molecular weight and intrinsic viscosity was obtained respectively by GPC and viscosimetry. Residual solvents in the polymer were determined using gas chromatography. The chromatographic conditions were optimized to enable the quantification of the solvents in concentrations of a few percent. The mechanical behavior of the semi-solid POE was determined by rheometric measurements. Hydrolysis of the polymer leads to the formation of the original triol and the carboxylic acid derived from the trialkyl ortho ester used in the transesterification step. No toxicological problems associated with these compounds are anticipated.
Phage P22 tail protein: gene and amino acid sequence (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhage P22 tail protein: gene and amino acid sequenceRobert T. Sauer, William Krovatin, Anthony R. Poteete, and Peter B. BergetCite this: Biochemistry 1982, 21, 23, 5811–5815Publication Date (Print):November 9, 1982Publication History Published online1 May 2002Published inissue 9 November 1982https://pubs.acs.org/doi/10.1021/bi00266a014https://doi.org/10.1021/bi00266a014research-articleACS PublicationsRequest reuse permissionsArticle Views105Altmetric-Citations65LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Robust high speed tracking servo system for optical disk system (2000)

This paper proposes a new high speed robust tracking control system based on both "zero phase error tracking" (ZPET) control system and disturbance observer for an optical disk recording system. In optical disk recording systems (for example CD-R), the tracking servo system must have a precise tracking response whose error is less than 0.1 [/spl mu/m] for a reference input signal with an amplitude of 100 [/spl mu/m]. Moreover, the tracking servo system can detect only the tracking error, i.e. the position difference between the optical spot and the track to be followed. For this purpose, the tracking servo system proposed in this paper estimates the reference input signal from the tracking error, and realizes the high speed robust tracking control based on ZPET control. Numerical simulation results point out that the proposed system has a quick and robust tracking response.
Surgical Treatment of Focal Epilepsy in Children; Results in 37 Patients (1997)

This report concerns 37 children and teenagers operated upon for intractable seizures between 1990 and 1994. Follow-up is at least 3 years. Fourteen children underwent pure temporal lobe resections; 71% are seizure free, and 93% have a better than 90% decrease in seizure frequency. The presence of a lesion on magnetic resonance imaging, the side of the lesion, or the presence of abnormal pathology had no influence on the result of resection. 28% of the children who had extratemporal resections are seizure free, and 83% have a greater than 90% decrease in seizure frequency. There was a trend to better results in those with a lesion on magnetic resonance imaging. In the small group with temporal plus extratemporal foci, the results were poor with only 60% showing a greater than 90% reduction in seizure frequency.
AirMixML: Over-the-Air Data Mixup for Inherently Privacy-Preserving Edge Machine Learning (2021)

Wireless channels can be inherently privacy preserving by distorting the received signals due to channel noise, and superpositioning multiple signals over-the-air. By harnessing these natural distortions and superpositions by wireless channels, we propose a novel privacy-preserving machine learning (ML) framework at the network edge, coined over-the-air mixup ML (AirMixML). In AirMixML, multiple workers transmit analog-modulated signals of their private data samples to an edge server who trains an ML model using the received noisy-and-superpositioned samples. AirMixML coincides with model training using mixup data augmentation achieving comparable accuracy to that with raw data samples. From a privacy perspective, AirMixML is a differentially private (DP) mechanism limiting the disclosure of each worker's private sample information at the server, while the worker's transmit power determines the privacy disclosure level. To this end, we develop a fractional channel-inversion power control (PC) method, a-Dirichlet mixup PC (DirMix(a)-PC), wherein for a given global power scaling factor after channel inversion, each worker's local power contribution to the superpositioned signal is controlled by the Dirichlet dispersion ratio a. Mathematically, we derive a closed-form expression clarifying the relationship between the local and global PC factors to guarantee a target DP level. By simulations, we provide DirMix(α)-PC design guidelines to improve accuracy, privacy, and energy-efficiency. Finally, AirMixML with DirMix(a)-PC is shown to achieve reasonable accuracy compared to a privacy-violating baseline with neither superposition nor PC.
Smart textiles for healthcare and medicine applications (WG1): state-of-the art report, CONTEXT Project (2020)

The aim of this document is to provide information on the state-of-the-art related to the topics covered by each working group within the CONTEXT project. It provides information on materials and technologies used to develop smart textiles with targeted performance, general applications of smart textiles in the field, case-studies on the use of smart textiles, opportunities for smart textiles considering the needs of each field, trends on the development of smart textiles in terms of market and technical expectations. This paper gives an overview of the potential of smart textiles for healthcare &amp; medicine, ongoing developments, state-of-the-art products and future developments.