gebhart/patrepeval huggingface dataset:
Surface-Induced Asymmetries during Spinodal Decomposition in Off-Critical Polymer Mixtures (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSurface-Induced Asymmetries during Spinodal Decomposition in Off-Critical Polymer MixturesGeorg Krausch, Edward J. Kramer, Frank S. Bates, J. F. Marko, G. Brown, and A. ChakrabartiCite this: Macromolecules 1994, 27, 23, 6768–6776Publication Date (Print):November 1, 1994Publication History Published online1 May 2002Published inissue 1 November 1994https://doi.org/10.1021/ma00101a015Request reuse permissionsArticle Views215Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-Alertsclose Get e-Alerts
Supplementary Figure S1 from Oral Iloprost Improves Endobronchial Dysplasia in Former Smokers (2023)

Supplementary Figure S1 from Oral Iloprost Improves Endobronchial Dysplasia in Former Smokers
A sintered nanoparticle p-n junction observed by a Seebeck microscan (2012)

A nanoparticular p-n junction was realized by a field-assisted sintering process, using p-type and n-type doped silicon nanoparticles. A spatially resolved Seebeck microscan showed a broad transition from the positively doped to the negatively doped range. Overshoots on both sides are characteristic for the transition. Despite the tip size being much larger than the mean particle size, information about the dopant distribution between the particles is deduced from modeling the measured data under different assumptions, including the limited spatial resolution of the tip. The best match between measured and modeled data is achieved by the idea of doping compensation, due to the sintering process. Due to a short time at high temperature during the field-assisted sintering process, solid state diffusion is too slow to be solely responsible for the observed compensation of donors and acceptors over a wide range. Therefore, these measurements support a densification mechanism based on (partial) melting and recrystallization.
Chiral germanium micro-gears for tuning orbital angular momentum (2022)

Group IV light sources with vertical emission and non-zero orbital-angular momentum (OAM) promise to unlock many novel applications. In this report, we demonstrate cylindrically symmetrical germanium micro-gear cavities, fabricated by etching a grating around the circumference of standard micro-disks, with periods ranging from 14 to 22. Photoluminescence (PL) measurements were done to identify the confined whispering-gallery modes (WGM). Finite-difference time-domain (FDTD) simulations were conducted to map the resonant modes to their modal profiles and characteristics. Vertical emission of WGMs with non-zero OAM was demonstrated, with a clear dependence of the OAM order ([Formula: see text]) on the WGM azimuthal order and the number of micro-gear grating periods. As the chirality, or the direction of rotation, is not controlled in a symmetrical cavity, we propose introducing staircase or triangular-shaped gear periods resulting in an asymmetry. By choosing the diameter, number of periods, and the asymmetrical direction of the gear-teeth, it is possible to generate OAM signals with certain wavelength, OAM order and chirality.
γ‐Hydroxybutyric acid is not a GABA‐mimetic agent in the spinal cord (1979)

Abstract γ‐Hydroxybutyric acid (GHB), a pharmacologically active central nervous system constituent, has been postulated to function as a γ‐aminobtyric acid (GABA) agonist. This hypothesis was tested directly on GABAergic synapses in isolated, superfused frog spinal cord. Addition of GHB to the superfustate produced effects on primary afferent terminals that were distinctly different from the effects of GABA. Thus, although both compounds depressed dorsal root potentials, GHB hyperpolarized terminals while GABA depolarized the same structures. The GABA responses were antagonized by bicuculline and picrotoxin, but these alkaloids did not change GHB's actions. In addtion, GHB altered neither high‐affinity uptake by cord slices, nor potassium‐evoked release of tritiated GABA from them. GHB did not directly release GABA from spinal slices preloaded with [ 3 H]GABA. These observations suggest that the central nervous system actions of GHB are not dependent upon its ability to activate GABAergic synapses or to modify GABAergic mechanisms.
A photoaffinity scan maps regions of the p85 SH2 domain involved in phosphoprotein binding. (1993)

Src homology 2 (SH2) domains are modular phosphotyrosine binding pockets found within a wide variety of cytoplasmic signaling molecules. Here we develop a new approach to analyzing protein-protein interfaces termed photoaffinity scanning, and apply the method to map regions of the phosphatidylinositol 3-kinase p85 SH2 domain that participate in phospho-protein binding. Each residue except phosphotyrosine (pY) within a tightly binding, IRS-1-derived phosphopeptide (GNGDpYMPMSPKS) was substituted with the photoactive amino acid, benzoylphenylalanine (Bpa). Whereas most substitutions had little effect on binding affinity, Bpa substitution of either Met (+1 and +3 with respect to pY) reduced affinity 50-100-fold to confirm their importance in the pYMXM recognition motif. In three cases photolysis of SH2 domain/Bpa phosphopeptide complexes led to cross-linking of > 50% of the SH2 domain; cross-link positions were identified by microsequence, amino acid composition, and electrospray mass spectrometric analyses. Bpa-1 cross-links within alpha-helix I, whereas Bpa+1 and Bpa+4 cross-link the SH2 domain within the flexible loop C-terminal to alpha-helix II. Moreover, cross-linking at any position prevents SH2 domain cleavage at a trypsin-sensitive site within the flexible loop between beta-strands 1 and 2. Therefore, at least three distinct SH2 regions in addition to the beta-sheet participate in phosphoprotein binding; the loop cross-linked by phosphopeptide residues C-terminal to pY appears to confer specificity to the phosphoprotein/SH2 domain interaction.
Heterocyclic Synthesis via the Tandem Thionium/N-Acyliminium Ion Cascade (1998)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTHeterocyclic Synthesis via the Tandem Thionium/N-Acyliminium Ion CascadeAlbert Padwa, Todd M. Heidelbaugh, Jeffrey T. Kuethe, and Michael S. McClureView Author Information Department of Chemistry, Emory University, Atlanta, Georgia 30322 Cite this: J. Org. Chem. 1998, 63, 20, 6778–6779Publication Date (Web):September 12, 1998Publication History Received13 July 1998Published online12 September 1998Published inissue 1 October 1998https://pubs.acs.org/doi/10.1021/jo981349whttps://doi.org/10.1021/jo981349wrapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views586Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Alkyls,Amides,Aromatic compounds,Cyclization,Ions Get e-Alerts
Development of TASP0410457 (TASP457), a novel dihydroquinolinone derivative as a PET radioligand for central histamine H3 receptors (2016)

We developed [(11)C]TASP0410457 as a radioligand enabling a robust quantification of H3Rs in all brain regions and demonstrated the utility of ex vivo LC-MS/MS and in vivo PET assays for selecting appropriate imaging tracers. [(11)C]TASP0410457 will help to examine the implication of H3Rs in neuropsychiatric disorders and to characterize emerging therapeutic agents targeting H3Rs.
II-VI Semiconductor Nanocrystals as Isolated Quantum Dots and in Complex Structures (1995)

Semiconductor crystallites which are 10's of Angstroms show a striking evolution of electronic properties with size. 1 These particles (quantum dots) are large enough to exhibit a crystalline core, but small enough that solid state electronic and vibrational band structure is not yet developed. We use a recently developed synthetic method for the fabrication of high quality nanometer size (1-10 nm) II- VI semiconductor crystallites with narrow size distributions (σ&lt;5%), emphasizing CdSe. 2 Optical characterization of their electronic structure reveals both molecular and bulk-like characteristics as well as properties which are unique to nanometer size crystallites. We observe a number of discrete electronic transitions, assign them as coming from the creation of delocalized "particle-in-a- sphere" states using the theory of Ref. 3 , and study their dependence on crystallite diameter. 4
Hybridization of β-Adrenergic Agonists and Antagonists Confers G Protein Bias (2019)

Starting from the β-adrenoceptor agonist isoprenaline and beta-blocker carvedilol, we designed and synthesized three different chemotypes of agonist/antagonist hybrids. Investigations of ligand-mediated receptor activation using bioluminescence resonance energy transfer biosensors revealed a predominant effect of the aromatic head group on the intrinsic activity of our ligands, as ligands with a carvedilol head group were devoid of agonistic activity. Ligands composed of a catechol head group and an antagonist-like oxypropylene spacer possess significant intrinsic activity for the activation of Gα<sub>s</sub>, while they only show weak or even no β-arrestin-2 recruitment at both β<sub>1</sub>- and β<sub>2</sub>-AR. Molecular dynamics simulations suggest that the difference in G protein efficacy and β-arrestin recruitment of the hybrid ( S)-22, the full agonist epinephrine, and the β<sub>2</sub>-selective, G protein-biased partial agonist salmeterol depends on specific hydrogen bonding between Ser<sup>5.46</sup> and Asn<sup>6.55</sup>, and the aromatic head group of the ligands.
Robust and Accurate Shape Model Matching Using Random Forest Regression-Voting (2014)

A widely used approach for locating points on deformable objects in images is to generate feature response images for each point, and then to fit a shape model to these response images. We demonstrate that Random Forest regression-voting can be used to generate high quality response images quickly. Rather than using a generative or a discriminative model to evaluate each pixel, a regressor is used to cast votes for the optimal position of each point. We show that this leads to fast and accurate shape model matching when applied in the Constrained Local Model framework. We evaluate the technique in detail, and compare it with a range of commonly used alternatives across application areas: the annotation of the joints of the hands in radiographs and the detection of feature points in facial images. We show that our approach outperforms alternative techniques, achieving what we believe to be the most accurate results yet published for hand joint annotation and state-of-the-art performance for facial feature point detection.
CELESTIAL OPTICAL INTERFEROMETRY: A NEW TOOL FOR ULTRAHIGH PRECISION STUDIES IN GRAVITY (2008)

The tremendous progress in the science and technology of timing devices and laser sources has reached a stage where their stability and coherence are sufficient for implementing unbalanced interferometers over a length scale exceeding the Earth–Moon distance. This opens up the possibility of optical homodyne interferometry over such distances, either to the Moon or to artificial satellites that are at large distances from the Earth. The precision of the measurement of changes in the orbital distance would increase by a factor of 10 4 or more, enabling new ultrahigh precision tests of the equivalence principle, study of gravitomagnetism, and of subtle gravitational phenomena, including the constancy of the gravitational constant and possible gravitational expansion of space. It would enable geodesy and tide studies with unprecedented precision. Such interferometers would also be useful for the detection and study of low frequency gravitational waves.
In Situ Thermal Study of Li[sub 1+x][Ni[sub 1∕3]Co[sub 1∕3]Mn[sub 1∕3]][sub 1−x]O[sub 2] Using Isothermal Micro-clorimetric Techniques (2006)

half-cells were investigated using isothermal microcalorimetry (IMC), and the results were quantitatively analyzed. The entropy change (dE/dT) calculated based on the IMC results during the charging process has the small range from , which agrees with the experimental results. The small dE/dT values could explain why has better thermal stability than that of other nickel based layered oxide such as , , and . Furthermore, the heat flow rate during the discharge process was also calculated from the cell's irreversible heat and the cell entropy change. The calculated values fit well the experimental data from the IMC results. This study also suggests the optimum voltage window of the operation of the cell based on cathode is between 4.1 and due to both, the self-discharge of the cell at higher voltages and the higher impedance of the cell in lower voltage regions.
Autologous Tumor-Specific Cytotoxicity of Tumor-Infiltrating Lymphocytes Derived from Human Renal Cell Carcinoma (1991)

Conditions for generating and expanding cytotoxic tumor-specific, tumor-infiltrating lymphocytes (TIL) were studied to improve the efficacy of adoptive cancer immunotherapy. Thus, we have examined the growth and cytolytic patterns of bulk culture TIL from human renal cell carcinoma (RCC) cultured in low (20 U/ml) or high (1,000 U/ml) dose interleukin (IL)-2, with or without irradiated autologous tumor stimulation. By 55 days in culture, TIL grown in the presence of IL-2 without tumor stimulation lost their lytic activity, whereas those exposed to tumor stimulation maintained high levels of cytotoxicity against autologous and/or nonautologous tumor targets. Only TIL grown with low dose IL-2 and autologous tumor maintained long-term (over 4 months in culture) specific cytotoxicity against the autologous tumor, even upon cryopreservation and regrowth. These TIL were 88-97% and 80% positive for CD3 and CD8, with a persistent subset exhibiting CD4+ CD8+ double positive staining. Their specific cytotoxic activity was major histocompatibility complex Class I-restricted and inhibited by pretreating the TIL with anti-CD3 monoclonal antibody. TIL exposed to the four types of culture conditions, low or high dose IL-2, with or without irradiated autologous tumors, and exhibiting different lytic specificities, all expressed mRNA for interferon-gamma and tumor necrosis factor (TNF)-alpha, but not for IL-1-beta, IL-4, IL-6, and granulocyte-macrophage colony stimulating factor. The degree of TNF-alpha mRNA expression correlated with the degree of autologous tumor-specific cytotoxicity of these TIL. This initial report demonstrates that antigen-specific cytotoxicity against the autologous tumor does, in fact, exist within the RCC tumors.(ABSTRACT TRUNCATED AT 250 WORDS)
Colorectal cancer screening and surveillance in Crohn's colitis (2012)

We detected cancer or dysplasia in 5.6% of patients with long-standing Crohn's colitis enrolled in a screening and surveillance program. Younger age at diagnosis of CD, longer disease course, and greater interval between exams were risk factors for the development of dysplasia.
WST11, A Novel Water‐soluble Bacteriochlorophyll Derivative; Cellular Uptake, Pharmacokinetics, Biodistribution and Vascular‐targeted Photodynamic Activity Using Melanoma Tumors as a Model¶ (2005)

ABSTRACT WST11 is a novel negatively charged water‐soluble palladiumbacteriochlorophyll derivative that was developed for vascular‐targeted photodynamic therapy (VTP) in our laboratory. The in vitro results suggest that WST11 cellular uptake, clearance and phototoxicity are mediated by serum albumin trafficking. In vivo , WST11 was found to clear rapidly from the circulation ( t 1/2 = 1.65 min ) after intravenous bolus injection in the mouse, whereas a longer clearance time ( t 1/2 = 7.5 min ) was noted in rats after 20 min of infusion. The biodistribution of WST11 in mouse tissues indicates hepatic clearance ( t 1/2 = 20 min ), with minor (kidney, lung and spleen) or no intermediary accumulation in other tissues. As soon as 1 h after injection, WST11 had nearly cleared from the body of the mouse, except for a temporal accumulation in the lungs from which it cleared within 40 min. On the basis of these results, we set the VTP protocol for a short illumination period (5 min), delivered immediately after WST11 injection. On subjecting M2R melanoma xenografts to WST11‐VTP, we achieved 100% tumor flattening at all doses and a 70% cure with 9 mg/kg and a light exposure dose of 100 mW/cm 2 . These results provide direct evidence that WST11 is an effective agent for VTP and provide guidelines for further development of new candidates.
The action spectra of cone photoreceptors in the turtle (Mauremys caspica) retina (1994)

Cone photoreceptors in the turtle retina are involved in intricate neuronal interactions with other retinal neurons that modify the responses of the cones to photons absorbed in their outer segments. Therefore, the action spectra of cones strongly depend upon the conditions of measurements. This study describes an attempt to derive the action spectra of turtle cones which are the least distorted by neuronal interactions. To achieve this goal, the photoresponses of cones and horizontal cells were recorded from the turtle retina under different conditions of adaptation using different patterns of the stimulating test flashes. The sensitivity action spectra, derived from small-amplitude (<1 mV) photoresponses, were strongly affected by the recording conditions indicating the contributions of multiple neuronal inputs. Action spectra, constructed from large criterion photoresponses, were less distorted by neuronal interactions and better described the spectral properties of the "isolated" cones. The action spectra of the hyperpolarizing inputs to chromaticity-type horizontal cells were derived by stimulating these cells with mixtures of a saturating red light and a monochromatic light of different wavelength and intensity. The action spectra were constructed from the intensity of the addend component needed to "pull down" the depolarizing response to the red component by a fixed criterion. These spectra, measured in red/green and yellow/blue C-type horizontal cells, are suggested to best represent the "isolated" M-cones and S-cones, respectively.
Highly Efficient Membraneless Glucose Bioanode Based on Corynascus thermophilus Cellobiose Dehydrogenase on Aryl Diazonium‐Activated Single‐Walled Carbon Nanotubes (2014)

Abstract We present an approach for electrode modification by using the oxidoreductase cellobiose dehydrogenase from the ascomycete Corynascus thermophilus ( Ct CDH). Ct CDH is a two‐domain enzyme, in which the catalytic dehydrogenase domain (DH CDH ) hosts flavin adenine dinucleotide (FAD) as cofactor and is connected through a flexible linker to a small cytochrome domain with a heme b cofactor (CYT CDH ). This domain is responsible for the electron transfer from DH CDH to macromolecular electron acceptors, and is capable of direct electron transfer (DET) with electrode surfaces. Ct CDH is optimal at pH values between 7 and 9 and exhibits one of the lowest apparent K M values for glucose (2.4×10 4 μ M ) in contrast to the majority of other CDHs, which have acidic optimal pH values and have very low or no activity for glucose. Glassy carbon (GC) electrodes were modified by drop‐casting single‐walled carbon nanotubes (SWCTs) and further modifying with aryl diazonium salts (DS). When adsorbed on such GC‐SWCT‐DS electrodes, CYT CDH showed efficient DET in the presence of a substrate. Six different functional groups for the aryl amines were studied and compared to non‐DS modified GC‐SWCT electrodes. The charge of the grafted aryl amines was investigated and it was found that surfaces modified with aniline, 4‐aminophenol, and 4‐aminobenzoic acid (ABA) contain negative charges at pH 7.4. On the other hand, surfaces modified with p ‐phenylenediamine (PD), N,N ‐dimethyl‐ p ‐phenylenediamine, and N,N ‐diethyl‐ p ‐phenylenediamine remain uncharged. To date, the highest DET current density ( J MAX =32.5 μA cm −2 for lactose and J MAX =16.2 μA cm −2 for glucose) for a CDH‐modified electrode at human physiological pH can be obtained by using a GC‐SWCT‐ABA Ct CDH modified electrode. The use of glutaraldehyde (GA) in GC‐SWCT‐PD‐modified electrodes increases the J MAX twofold. The modified electrodes with DS showed a more negative onset potential for the catalytic current. For GC‐SWCT‐ABA modified electrodes and GC‐SWCT‐PD with GA, a change in the onset potential of −62 and −66 mV, respectively, was found compared with non‐DS modified electrodes. The prepared bioanodes show a loss in response current of 15 % after 9 days of continuous measurements from the original signal in 5 m M glucose, using 50 m M phosphate buffer solution at pH 7.40 at 37 °C.
A Novel Type of Deubiquitinating Enzyme (2003)

A previous report from this laboratory described two novel proteins that have sequence similarity to A20, a negative regulator of NF-kappaB (Evans, P. C., Taylor, E. R., Coadwell, J., Heyninck, K., Beyaert, R., and Kilshaw, P. J. (2001) Biochem. J. 357, 617-623). One of these molecules, cellular zinc finger anti-NF-kappaB (Cezanne), a 100-kDa cytoplasmic protein, also suppressed NF-kappaB. Here we demonstrate that Cezanne is a novel deubiquitinating enzyme, distinct from the two known families of deubiquitinases, Types I and II. We show that Cezanne contains an N-terminal catalytic domain that belongs to the recently discovered ovarian tumor protein (OTU) superfamily, a group of proteins displaying structural similarity to cysteine proteases but having no previously described function. Recombinant Cezanne cleaved ubiquitin monomers from linear or branched synthetic ubiquitin chains and from ubiquitinated proteins. Mutation of a conserved cysteine residue in the catalytic site of the proteolytic domain caused Cezanne to co-precipitate polyubiquitinated cellular proteins. We also provide evidence for an additional ubiquitin binding site in the C-terminal part of the molecule. Our data provide the first demonstration of functional activity among OTU proteins.