gebhart/patrepeval huggingface dataset:
Prevention of early cell death in peripheral blood lymphocytes of HIV infected individuals by an anti-oxidant: N-Acetyl-Cysteine (1994)

Peripheral blood lymphocytes (PBLs) from HIV seropositive patients, cultured in growth factor free medium for 3 days show an important loss of viability and an apoptosis phenomenon in T cell subsets compared to healthy donor’s PBLs. Different reports describe a decrease of intracellular Glutathione (GSH) in T lymphocyte subsets correlated to the stage of AIDS disease. N-Acetyl-cysteine (NAC) has been described to increase Glutathione level and restore cellular redox pathways. 15 patients were treated with 600 to 1200 mg of NAC per day over a year. Viability and apoptosis profiles were followed over a 10 day period. In a flow cytometry (FCM) test using Acridine Orange, we noted a cell population with low DNA staining intensity in PBLs from HIV seropositive patients. Agarose gel electrophoresis revealed DNA fragmentation correlated to this phenomenon, suggesting apoptosis. With NAC treatment we observed a systematic and stable amelioration of viability results from 2 months to 6 months of NAC treatment. At day 3 no cell death or apoptosis is detected in PBLs from healthy donors and patients treated over 6 months. At day 6 PBLs from healthy donors have up to 30% dead and apoptotic cells (60 to 100% for non or recently treated patients). There is no cell death before day 8 to 10 in PBLs from patients treated over 6 months. N-Acetyl-Cystein administration to HIV seropositive patients seems to prevent early cell death and to lead an “overprotection” of patients’ PBLs.
Seeing Parkinson Disease in the Retina (2020)

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UV- and Thermo-Controllable Azobenzene-Decorated Polycarbodiimide Molecular Springs (2018)

Molecular switches offer wide applicability through conformational changes which can be triggered by external stimuli. Azobenzenes are excellent candidates to contribute toward a rational design of molecular switches because they exist as either cis or trans isomers as a result of the dynamic photoisomerization process. In this study, we leverage the azobenzene stimuli response by attaching it as a pendant group on polycarbodiimides synthesized using screw sense polymerization. The exposure of the polymer sample in solution to UV light induces the transformation of the azobenzene pendant groups to the cis isomer with re-emergence of the trans conformer under visible light or heat. Corroborating experimental and computational data reveal that these events induce spring-like expansion–contraction motions throughout the helical backbone. Our finding suggests the use of polycarbodiimide-derived photoswitches as dynamic materials in biological applications and materials science.
Purcell effect with microwave drive: Suppression of qubit relaxation rate (2014)

We analyze the Purcell relaxation rate of a superconducting qubit coupled to a resonator, which is coupled to a transmission line and pumped by an external microwave drive. Considering the typical regime of the qubit measurement, we focus on the case when the qubit frequency is significantly detuned from the resonator frequency. Surprisingly, the Purcell rate decreases when the strength of the microwave drive is increased. This suppression becomes significant in the nonlinear regime. In the presence of the microwave drive, the loss of photons to the transmission line also causes excitation of the qubit; however, the excitation rate is typically much smaller than the relaxation rate. Our analysis also applies to a more general case of a two-level quantum system coupled to a cavity.
Long-term Stabilization of Aqueous Doxycycline Formulations, in Mucoadhesive Hydrogels for Treatment of Oral Mucosal Conditions (2019)

In conclusion, it is possible to prevent doxycycline from both oxidation and epimerization in an aqueous formulation, for up to 5 years.
Exploring the dielectric polarization and ionic conduction mechanisms in sodium-containing silicate and borosilicate glasses (2023)

The dielectric and electrical behavior of a sodium silicate glass (soda-lime-silica; SLS) and a sodium borosilicate glass (D263T) are systematically and comprehensively characterized by a combination of ac and dc techniques at various temperatures and electric fields. This study reveals that Na+ migration primarily influences the dielectric loss, energy efficiency, and leakage current in these glasses, with a less detrimental effect in D263T due to its higher activation energy for ionic conduction. Moreover, this study identifies an additional relaxation mechanism contributing to the leakage current in D263T which was not observed in SLS. The origin of this mechanism has not been extensively explored, and it is believed to arise from a more limited migration of Na+ ions associated with the short migration and accumulation of a second and less mobile ion near the anode.
GridLAB-D: An agent-based simulation framework for smart grids (2014)

Simulation of smart grid technologies requires a fundamentally new approach to integrated modeling of power systems, energy markets, building technologies and the plethora of other resources and assets that are becoming part of modern electricity production, delivery and consumption systems. As a result, the US Department of Energy's Office of Electricity commissioned the development of a new type of power system simulation tool called GridLAB-D(TM) that uses an agent-based approach to simulating smart grids. This paper presents the numerical methods and approach to time-series simulation used by GridLAB-D and reviews applications in power system studies, market design, building control system design, and integration of wind power in a smart grid.
Impaired somatostatin response to orally administered glucose in Type II diabetes entails both somatostatin-28 and -14 and is associated with deranged metabolic control (1989)

lack of somatostatin response to glucose in non-insulin-dependent diabetes mellitus is associated with deranged metabolic control. Unresponsiveness to glucose entails the secretion of both somatostatin-28 and -14.
Activating Mutations of the Noonan Syndrome-Associated SHP2/PTPN11 Gene in Human Solid Tumors and Adult Acute Myelogenous Leukemia (2004)

The SH2 domain-containing protein-tyrosine phosphatase PTPN11 (Shp2) is required for normal development and is an essential component of signaling pathways initiated by growth factors, cytokines, and extracellular matrix. In many of these pathways, Shp2 acts upstream of Ras. About 50% of patients with Noonan syndrome have germ-line PTPN11 gain of function mutations. Associations between Noonan syndrome and an increased risk of some malignancies, notably leukemia and neuroblastoma, have been reported, and recent data indicate that somatic PTPN11 mutations occur in children with sporadic juvenile myelomonocytic leukemia, myelodysplasic syndrome, B-cell acute lymphoblastic leukemia, and acute myelogenous leukemia (AML). Juvenile myelomonocytic leukemia patients without PTPN11 mutations have either homozygotic NF-1 deletion or activating RAS mutations. Given the role of Shp2 in Ras activation and the frequent mutation of RAS in human tumors, these data raise the possibility that PTPN11 mutations play a broader role in cancer. We asked whether PTPN11 mutations occur in other malignancies in which activating RAS mutations occur at low but significant frequency. Sequencing of PTPN11 from 13 different human neoplasms including breast, lung, gastric, and neuroblastoma tumors and adult AML and acute lymphoblastic leukemia revealed 11 missense mutations. Five are known mutations predicted to result in an activated form of Shp2, whereas six are new mutations. Biochemical analysis confirmed that several of the new mutations result in increased Shp2 activity. Our data demonstrate that mutations in PTPN11 occur at low frequency in several human cancers, especially neuroblastoma and AML, and suggest that Shp2 may be a novel target for antineoplastic therapy.
On fracture behaviour of CF/PEKK laminates: Mode I fracture toughness (2023)

View Video Presentation: https://doi.org/10.2514/6.2023-2198.vid The interest regarding the use of thermoplastic composite materials in aeronautical structures is increasing in the last years, nevertheless in literature there are few studies concerning the interlaminar properties of CF/PEKK laminates obtained with out-of-autoclave consolidation process. In this work it is studied the interlaminar mode I fracture behavior of laminates obtained from the stacking of a prepreg tape consolidated by heated press. A particular focus is placed on the effect of the pressure applied during the consolidation process of the prepreg, regarding the interlaminar fracture resistance performances of the consolidated material. Three different pressure levels were investigated by testing ASTM D5528 double cantilever beam testing and by an investigation on the material’s microstructure.
Supermacrochelate Complexes Containing an Artificial Nucleic Acid Backbone and Derived from Excellent Ligands Formed by Treating Platinum Anticancer Agents with Nucleotide Triphosphates (1998)

Potent metal-ion chelators, cis-A2Pt(5‘-GTP)2 (A2 = two amines or a diamine), form novel “supermacrochelate” cis-A2Pt(5‘-GTP)2M complexes with unusual properties. The artificial metal-linked sugar−phosphate backbone in enPt(5‘-GTP)2La exhibits slow La3+ exchange, is not completely disrupted by EDTA, persists intact even at pH 1.5, and is an informative model of the cross-link formed by cis-A2PtX2 anticancer drugs and the N7 of adjacent G residues in DNA.
Self-consistent calculations of spatial electron densities in quantum dot's using a coupled recursive green's function and poisson solver (2000)

We are utilizing the Recursive Green’s function method to calculate the conductance in quantum dots as a function of Fermi energy, magnetic field and random potentials. We have extended the use of the method to calculate a self-consistent electron charge density and potential profile in the dot. This is accomplished by feeding the imaginary part of the Green’s functions into a Poisson solver and feeding the potential obtained from the solver back into the Green’s functions solver, until self consistency is better satisfied. Obtaining a more realistic density and potential profiles gives a better physical understanding to what happens in the dot, and provides more accurate results. We demonstrate the process with a 0.3 ´ 0.3 mm dot formed at a GaAs/AlGaAs 2DEG.
Two Applications of the Generalized Ptolemy Theorem (2002)

Click to increase image sizeClick to decrease image size Additional informationNotes on contributorsShay GueronSHAY GUERON is a faculty member of the department of mathematics at the University of Haifa, Israel. His research interests are in applied mathematics (mathematical biology, and computations). He is also interested in problem solving and mathematical competitions, and has been the Israeli Team Leader for the International Mathematical Olympiad since 1994.
A Preliminary Study of the Effect of Ionospheric Scintillation on WAAS User Availability in Equatorial Regions (1998)

While Wide Area Augmentation System (WAAS) user
performance is expected meet aviation requirements
under most conditions, infrequent ionospheric anomalies
may result in significant degradation at certain times and
locations. Scintillation, caused by local ionospheric
plasma anomalies that intercept the path of GPS signals,
can cause severe signal fades and phase vacillations that
may lead to loss of signal lock or increased measurement
errors. The degree to which scintillation will affect user
availability is not well known, however, and detailed
models of scintillation phenomena are limited by the
sparse amount of data available.
To evaluate the threat that scintillation may pose to
WAAS users, existing scintillation models have been
adapted to provide probability distributions for signal
amplitude and phase variations. Samples from these
distributions are fed into a simplified receiver simulation
that outputs the probability of losing signal lock given a
specified nominal signal-to-noise ratio. These results are
integrated with an existing WAAS Service Volume
Model (SVM) to assess the resulting user availability for
an example WAAS network covering South America.
The results indicate that in susceptible locations,
moderate scintillation results in a high probability of
loss-of-lock for low-elevation satellites, and strong
scintillation does the same for higher-elevation satellites.
The problem is particularly bad for codeless L2 tracking
used by existing WAAS networks to generate ionosphere
measurements. However, when compared to the case of
large ionosphere delays without scintillation, precision
approach availability is not much worse because these
periods have higher ionosphere errors and thus signifi-cantly
diminished availability relative to nominal
ionosphere conditions. Non-precision applications of WAAS retain high availability even under scintillation.
Better assessments of the effect of scintillation on WAAS
will be possible once data from the upcoming solar peak
in 2000-01 is delivered by the National Satellite Testbed
(NSTB) and by Phase 1 WAAS reference stations.
Chemische und biologische Aspekte von “Nutritional Immunity” – Perspektiven für neue Antiinfektiva mit Fokus auf bakterielle Eisenaufnahmesysteme (2017)

Abstract Eine der Verteidigungsstrategien eines Wirtes gegen bakterielle Infektionen ist der Entzug essentieller Metallionen, insbesondere von Eisenionen, durch Komplexierung. Dies wird als Nährstoffimmunität (“nutritional immunity”) bezeichnet. Bakterien haben jedoch Strategien zur Anpassung an den Eisenmangel entwickelt. Sie “stehlen” zum Beispiel Eisen vom Wirt oder von anderen Bakterien durch spezifische Chelatoren mit einer hohen Affinität für Eisen. Die komplexen Wechselwirkungen zwischen Wirt und Pathogen zur Homöostase von Metallionen bieten zahlreiche Angriffspunkte für die Entwicklung neuer antibakterieller Wirkstoffe. Dieser Aufsatz ist auf Prozesse mit Eisenbeteiligung fokussiert. Es werden die neuesten Entwicklungen und mögliche Perspektiven für die Entwicklung von Antibiotikaresistenzen diskutiert.
SINR Analysis of a Narrowband Interference Cancellation Scheme in OFDM Communication Systems (2014)

Narrowband interference (NBI) is a significant impairment for multi-carrier modulation systems in both wireless and wireline channels. NBI may be generated by switching power supplies and legacy communication systems, and in many instances may be tonal in nature [1]. Recently, a novel method for mitigating the effect of NBI was proposed in [2] which works on minimizing the NBI spectral leakage by downconvering, nulling, and upconverting the received signal. In this paper we address the key question of how the algorithm performs as the number of interferers scales. We perform a distortion analysis on the received signal and obtain the following results under the assumption of an idealized analog front end: a) the distortion scales linearly with the number of interferers b) the distortion is independent of interferer frequency and amplitude. We also carry out a signal-to-interference noise ratio (S!NR) analysis of the proposed algorithm and show a good match between theory and simulation results.
Single-frame measurement of ultrafast spatiotemporal vortex pulses (2022)

We demonstrated a simple method to quantitatively characterize the spatiotemporal orbital angular momentum (ST-OAM) of light. Our method can measure the presence of ST-OAM, space-time topological charges, OAM helicity, pulse dispersion, and beam divergence.
Accessible Nearfields by Nanoantennas on Nanopedestals for Ultrasensitive Vibrational Spectroscopy (2014)

A plasmonic nanoring antenna system on a nanopedestal, providing larger and more accessible local electromagnetic fields, enables higher surface-enhanced fluore­scence IR absorption (SEIRA) signals than conventional designs on dielectric substrates. Experimental results and finite difference time domain (FDTD) simulations demonstrate that such an improvement in the absorption signal of protein vibrational modes is directly proportional to the overlap between the optical fields and the biomolecules in the vicinity of the antenna. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
PROTEIN PATTERNS DURING GERMINATION OF Lactuca sativa `Empire'. (1990)

Lettuce seeds were germinated at 20 C in the dark in water and sampled at various intervals during the first 18h of germination to determine quantitative and qualitative differences in proteins. The soluble protein fraction was partitioned into albumins and globulins by dialysis and the proteins of the globulin fraction were visualized by SDS-PAGE. Heat stable proteins were obtained by boiling the proteins, cooling on ice, and resuspending in buffer. The soluble protein content remained constant during the first 8h of germination. Thereafter protein content decreased and was 6% of the amount present in unimbibed seed in 21 day old seedlings. The ratio of heat stable to heat unstable proteins decreased during the germination process. No differences in banding patterns were observed when the soluble protein fraction were run on SDS-PAGE. However, on gels run with the globulin fraction a 57 kD protein appeared 4 and 8 h after imbibition and had disappeared by 12 h after imbibition. The role of proteins and heat-stable proteins during germination and prevention of dessication during early seedling growth is discussed.
Agrobacterium-mediated Transformation of Torenia (Torenia fournieri). (1995)

A method for Agrobacterium -mediated transformation of torenia (Scrophulariaceae) is reported. Leaf segments of torenia plants grown in vitro were infected with the Agrobacterium strain LBA4404 harboring a binary vector containing the neomycin phosphotransferase IIgene, P -glucuronidase (GUS) gene lvith an intron and hygromycin phosphotransferase gene. The infected explants were cultured on Murashige and Skoog medium supplemented with 1 mg/l benzyladenine, 100 mgfl carbenicillin and 300 mg/l kanamycin (selection medium) for regeneration. Twelve shoots out of 67 shoots which regenerated from green compact calli on the selection medium were GLTS-positive. Polymerase chain reaction analysis confirmed the presence of the GUS gene in the GUS-positive plants. Mendelian inheritance of the GUS activity in the progenies of the transformed plants was demonstrated.
ChemInform Abstract: Asymmetric Hetero Diels‐Alder Reactions of Danishefsky′s Diene and Glyoxylate Esters Catalyzed by Chiral Bisoxazoline Derived Catalysts. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Does Transendocardial Injection of Mesenchymal Stem Cells Improve Myocardial Function Locally or Globally? (2014)

These findings illustrate a dichotomy in regional responses to TESI. Although scar size reduction was evident in all scar segments, scar size reduction and ventricular functional responses preferentially occurred at the sites of TESI versus non-TESI sites. Furthermore, improvement was greatest when segmental left ventricular dysfunction was severe.
Patterns of healthcare resource utilization prior to anterior cervical decompression and fusion in patients with radiculopathy (2017)

In the two years prior to ACDF, healthcare resource utilization is extremely high. Given that these patients ultimately undergo surgical intervention, opportunities to reduce charges of conservative care exist.
Study of the influence of material properties and geometric parameters on warpage for Fan-Out Wafer Level Packaging (2018)

Fan-out wafer level packaging (FO-WLP) has increased interest for a wide range of applicationsHowever, wafer warpage is one big challenge during wafer process, which needs to be addressed for successful process integration. In this study, the warpage of molded wafer with and without temporary bonding material (TBM) is investigated. Finite Element (FE) modeling was used to identify the key parameters influencing wafer warpage using virtual experiments. Design of Experiments (DOE) were performed for different geometrical parameters (such as mold compound (MC) and die thicknesses, die size) and thermal-mechanical properties of the MC and TBM materials (Young's modulus, CTE, Tg...). Finally, some important parameters affecting the warpage of molded wafers are recommended. Based on FE modeling, guidelines for material selection and geometric design are generated.
Materials-Process Interactions in Ternary Alloy Semiconductors. (1984)

Properties of InGaAs,implantation doping of InGaAs, Photoluminescence Properties of InGaAs, surface studies on InGaAs, X-ray photoelectron spectroscopy and electron energy loss spectroscopy studies in InGaAs. The report describes the electrical and optical properties of In(0.53)Ga(0.47)As layers grown by liquid phase epitaxy on InP substrates. The report also describes on implantation doping experiments to form n- and p-type layers in In(0.53)Ga(0.47)As. High degree of n-type electrical activation can be achieved in Si-implanted samples. Formation of p-type layers by Be- or Mg-ion implantation is much more difficult. X-ray photoemission (ELS) studies show that the native oxides present on chemically etched In(0.53)Ga(0.47)As consist predominantly of As2O3 and oxides of In. Plasma enhanced deposition of SiO2 at 300 deg C does not significantly change the thickness of the native oxide. Although capacitance-voltage measurements on the MIS capacitors on In(0.53)Ga(0.47)As exhibit high, the surface potential can be modulated, PECVD SiO2 appears to be a viable candidate as a gate dielectric for In(0.53)Ga(0.47)As MISFETs.
A finite-element model with closed-form solutions to workpiece deflections in turning (1999)

Simulation models for workpiece deflections play an important role in determining conditions to maximize the part accuracy in machining processes as well as in analysing the dynamic response of the machining system. In this paper, the crosssectional deflection of the workpiece due to all cutting force components (radial, axial and tangential) is determined using the finite-element method. Three workpiece mounting types generally used in industrial practice are considered. The change in the workpiece diameter during machining can easily be taken into account with this model. Furthermore, the finite-element reponses are derived in closed form which enables rapid and continuous solutions along the part length. Numerical examples are treated for which the workpiece deflections calculated from this model are compared with those computed only from the radial cutting force component as usually done by several simplified models. From the results obtained, the proposed model is generally recommended to improve turning simulations.