gebhart/patrepeval huggingface dataset:
Evaluation of absorption and emission properties of Yb/sup 3+/ doped crystals for laser applications (1993)

The emission and absorption properties of numerous host crystals doped with Yb/sup 3+/ ions have been studied. The hosts which have been selected include LiYF/sub 4/, LaF/sub 3/, SrF/sub 2/, BaF/sub 2/, KCaF/sub 3/, KY/sub 3/F/sub 10/, Rb/sub 2/NaYF/sub 6/, BaY/sub 2/F/sub 8/, Y/sub 2/SiO/sub 5/, Y/sub 3/Al/sub 5/O/sub 12/, YAlO/sub 3/, LuPO/sub 4/, Ca/sub 5/(PO/sub 4/)/sub 3/F, LiYO/sub 2/, and ScBO/sub 3/. Spectral determinations have been made of the resonant absorption and emission cross sections between 850 and 1100 nm, and the emission decay times of the upper laser level have been measured. The emission cross sections have been evaluated using the absorption cross section and principle of reciprocity, and again using the Fuchtbauer-Ladenberg formula. Agreement between the two methods is within 20% for most materials. The results are discussed in the framework of requirements for an effective diode-pumped Yb/sup 3+/ laser system. Ca/sub 5/(PO/sub 4/)/sub 3/F:Yb is predicted to exhibit the most useful laser properties and is expected to be far superior to Y/sub 3/Al/sub 5/O/sub 12/:Yb in many key microscopic parameter values.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The mTOR Inhibitor Temsirolimus Added to Rituximab Combined With Dexamethasone, Cytarabine, and Cisplatinum (R-DHAP) for the Treatment of Patients With Relapsed or Refractory DLBCL – Results From the Phase-II STORM Trial (2021)

There is a high need for novel treatment options in relapsed and refractory diffuse large B-cell lymphoma. Single agent mammalian target of rapamycin (mTOR) inhibitor treatment has shown promising efficacy in this entity. Here, we report on the results of the mTOR-inhibitor temsirolimus combined to standard rituximab-DHAP salvage regimen in a prospective, multicenter, phase II, open-label study. The STORM regimen consisted of rituximab 375 mg/m<sup>2</sup> (day 2) and DHAP (dexamethasone 40 mg day 3-6, cisplatinum 100 mg/m<sup>2</sup> day 3, cytarabine 2 × 2 g/m<sup>2</sup> day 4) with temsirolimus added on day 1 and 8 of a 21-day cycle, with 2 to 4 cycles planned. In part I, dose levels of 25, 50, 75, and 100 mg for temsirolimus were predefined. Based on the observed toxicity profile, a temsirolimus dose of 25 mg was defined as recommended dose for the part II extension cohort of the trial. The intention-to-treat cohort comprised 53 patients. Median age was 63 years and median number of prior regimen was 1. All but 1 patient had prior rituximab exposure. Temsirolimus dose was 50 mg on day 1 and 8 in 6 patients from the part I of the trial and 25 mg in the remaining 47 patients. In general, treatment was well tolerated with leucopenia and thrombocytopenia as most frequent severe adverse events. The overall response rate after the last cycle of temsirolimus R-DHAP was 66% with 24% complete responses. The ability to mobilize stem cells was not impaired by the treatment regimen. Twenty-eight patients received consolidation treatment with high-dose therapy (HDT) and stem cell transplantation. Median duration of response was not reached. The total 2-year progression-free survival (PFS) and overall survival (OS) were 53% and 59%. Patients who were consolidated with HDT achieved a 2-year PFS and a 2-year OS of 77.8% and 82.1%, respectively. We conclude that temsirolimus can be safely added to rituximab and DHAP with promising activity.
ChemInform Abstract: REACTION OF DICARBONYL COMPOUNDS WITH DIMETHYL 3‐KETOGLUTARATE. INFLUENCE OF STERIC EFFECTS ON SUCCESS OF THE CONDENSATION (1982)

Abstract Bei der Kondensation von Acetondicarbonsäuredimethylester (II) mit dem Ketoaldehyd (I) entsteht das bicyclische Diketon (III).
블랙박스 영상용 자동차 번호판 인식을 위한 최소 자승법 기반의 번호판 영상 이진화 알고리즘 (2018)

자동차 블랙박스 영상용 자동차 번호판 인식 시스템에서는 수시로 변하는 도로 주변의 외부 환경에 의해 자동차 번호판에 그림자가 존재하는 경우가 많이 발생한다. 이러한 그림자는 번호판의 문자와 숫자의 개별 문자 분할 과정에서 예상하지 않은 오류를 발생시키게 되고, 그 결과 전체적인 자동차 번호판 인식률을 저하...
Acute Dialysis Quality Initiative (ADQI) XIV Sepsis Phenotypes and Targets for Blood Purification in Sepsis (2016)

Despite widespread use, there is currently no consensus on how extracorporeal blood purification therapies should be applied or studied in patients with sepsis. One major obstacle has been the lack of clear descriptions of specific sepsis phenotypes tied to mechanisms that would permit the identification of molecular targets. Current evidence suggests that sepsis-related morbidity and mortality involve widely different clinical phenotypes that variably include mitochondrial dysfunction, abnormalities of vascular biology including endothelial dysfunction and coagulopathy, epithelial dysfunction, and immune suppression and dysregulation. While most cases of sepsis involve some element of all of these pathobiologic processes, the magnitude of each varies greatly from patient to patient in part as a result of the pathogen and in part related to host-specific factors. Thus, the purpose of the fourteenth international consensus conference of acute dialysis quality initiative was to develop consensus for a conceptual model of sepsis-induced organ failure that can be treated by extracorporeal blood purification and possibly also with drugs or other therapies. We assembled a group of experts from around the world and used a modified Delphi method to reach consensus. Specific findings and recommendations for future research are provided in the four accompanying papers.
Deep learning acceleration in 14nm CMOS compatible ReRAM array: device, material and algorithm co-optimization (2022)

We show for the first time in hardware that in contrast to conventional stochastic gradient descent (SGD), our modified SGD algorithm (TTv2) together with a co-optimized ReRAM material achieves respectable accuracy (98%) on reduced MNIST classification (0 & 1), approaching a floating point (FP) baseline. To extrapolate these insights towards larger DNN training workloads in simulations, we establish an analog switching test sequence and extract key device statistics from 6T1R ReRAM arrays (up to 2k devices) built on a 14nm CMOS baseline. With this, we find that for larger DNN workloads, device and algorithm co-optimization shows dramatic improvements in comparison to standard SGD and baseline ReRAM. The gap to the reference floating-point accuracy across various tested DNNs indicates that further material and algorithmic optimizations are still needed. This work shows a pathway for scalable in-memory deep learning training using ReRAM crossbar arrays.
Supplementary Figure 2 from A Diverse Array of Cancer-Associated <i>MTOR</i> Mutations Are Hyperactivating and Can Predict Rapamycin Sensitivity (2023)

&lt;p&gt;PDF file 106K, S2215Y mTOR activates mTORC1 signaling similar to WT and mutant PI3K-p110alpha&lt;/p&gt;
Graph Feature Gating Networks (2021)

Graph neural networks (GNNs) have received tremendous attention due to their power in learning effective representations for graphs. Most GNNs follow a message-passing scheme where the node representations are updated by aggregating and transforming the information from the neighborhood. Meanwhile, they adopt the same strategy in aggregating the information from different feature dimensions. However, suggested by social dimension theory and spectral embedding, there are potential benefits to treat the dimensions differently during the aggregation process. In this work, we investigate to enable heterogeneous contributions of feature dimensions in GNNs. In particular, we propose a general graph feature gating network (GFGN) based on the graph signal denoising problem and then correspondingly introduce three graph filters under GFGN to allow different levels of contributions from feature dimensions. Extensive experiments on various real-world datasets demonstrate the effectiveness and robustness of the proposed frameworks.
REMOVED: Filtration Properties of Activated Sludge Filter Cakes (2012)

This article has been removed: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been removed at the request of the Executive Publisher. This article has been removed because it was published without the permission of the author(s).
Simurgh: A Framework for Cad-Driven Deep Learning Based X-Ray CT Reconstruction (2022)

High-resolution X-ray computed tomography (XCT) is an important technique for the inspection of additively manufactured (AM) parts. While XCT is typically used off-line to inspect a subset of manufactured parts, significantly accelerating measurement speed while retaining accuracy would enable use of XCT for in-line inspection to rapidly identify defects in each part as it is manufactured. Here, we propose a deep learning (DL) based approach that uses computer aided design (CAD) models of the AM parts and physics-based information to rapidly produce high-quality reconstructions from sparse XCT measurements without high quality ground truth data. Our approach uses a generative adversarial neural network (GAN) to produced realistic training data from the CAD-based simulations and a deep neural network that is trained using data from the first stage to produce accurate 3D reconstructions. Using experimental XCT data of metal parts, we demonstrate enhanced defect detection capabilities while dramatically reducing the scan time.
The non‐proteolytic house dust mite allergen Der p 2 induce NF‐κB and MAPK dependent activation of bronchial epithelial cells (2009)

Summary Background House dust mites (HDM) are well‐known as a source of indoor aeroallergens and for causing allergic airway diseases. Some proteolytic HDM allergens are known to activate respiratory epithelial cells to produce pro‐inflammatory mediators, while there is limited knowledge regarding such activity among non‐proteolytic HDM allergens. Objective To investigate whether Der p 2, a major non‐proteolytic allergen of Dermatophagoides pteronyssinus , activates respiratory epithelial cells to produce mediators involved in asthma pathogenesis and to elucidate the mechanism of such activation. Methods The human bronchial epithelial cell line BEAS‐2B, normal human bronchial epithelial (NHBE) cells and the alveolar epithelial cell line A549 were exposed to recombinant Der p 2. Following exposure, we analysed a panel of soluble mediators and cell adhesion receptors involved in asthma pathogenesis by promoting recruitment, survival and binding of inflammatory cells. The involvement of nuclear factor (NF)‐κB and mitogen‐activated protein kinases (MAPKs) was studied using specific inhibitors. Results Der p 2 activated bronchial BEAS‐2B and NHBE cells, but not alveolar A549 cells. In BEAS‐2B cells Der p 2 induced dose‐dependent up‐regulation in both mRNA level and protein secretion of granulocyte‐macrophage colony‐stimulating factor, IL‐6, IL‐8, monocyte‐chemotactic protein‐1 and macrophage inflammatory protein‐3α. Secretion as well as surface expression of intercellular adhesion molecule (ICAM)‐1 was also up‐regulated, which was associated with increased adhesion of monocytes to the epithelial cells. The release of cytokines and chemokines was regulated by NF‐κB and MAPK activation in different ways, while expression of ICAM‐1 was solely dependent on NF‐κB activation. Conclusion These results show that Der p 2 activates respiratory epithelial cells, indicating that this non‐proteolytic allergen, in addition to its immunogenic properties, can aggravate respiratory airway disease by adjuvant‐like activation of the lung epithelium.
Threshold saturation on BMS channels via spatial coupling (2010)

We consider spatially coupled code ensembles. A particular instance are convolutional LDPC ensembles. It was recently shown that, for transmission over the binary erasure channel, this coupling increases the belief propagation threshold of the ensemble to the maximum a-priori threshold of the underlying component ensemble. We report on empirical evidence which suggests that the same phenomenon also occurs when transmission takes place over a general binary memoryless symmetric channel. This is confirmed both by simulations as well as by computing EBP GEXIT curves and by comparing the empirical BP thresholds of coupled ensembles to the empirically determined MAP thresholds of the underlying regular ensembles. We further consider ways of reducing the rate-loss incurred by such constructions.
Supplementary Tables 1, 3, 5-7 from Vaccination with Designed Neopeptides Induces Intratumoral, Cross-reactive CD4<sup>+</sup> T-cell Responses in Glioblastoma (2023)

&lt;p&gt;Supplementary Table 1. Somatic mutations of the patient's glioblastoma; Supplementary Table 2. See Excel File; Supplementary Table 3. Literature-derived, glioblastoma-associated TAAs; Supplementary Table 4. See Excel File; Supplementary Table 5. Over-/highly expressed genes that were chosen for the design of vaccine peptides; Supplementary Table 6. Peptide cocktails for vaccination; Supplementary Table 7. Antibodies for imaging mass cytometry.&lt;/p&gt;
The Effect of Limiting Impact Force on Abdominal Injury: A Preliminary Study (1986)

&lt;div class="htmlview paragraph"&gt;This report describes a series of experiments using Hexcel(TM) to limit the impact force in lateral abdominal impacts. Two hundred fourteen (214) anesthetized New Zealand White rabbits were impacted at 5 to 15 m/s using a pneumatic impactor. Injury responses from tests with a force-limiting impact interface (94 tests) were compared with the responses from tests with a rigid impact interface (120 tests) having the same level of lateral abdominal compression. The Hexcel had a length of 3 inches, the same diameter as the rigid impactor, and crushed at a constant force (pressure level of 232 kPa (33 psi)) once deformation was initiated.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;The results of these tests showed that the probability of serious abdominal injury did not change significantly with the Hexcel, even though peak pressures were reduced to as little as one third of their previous values. The overall abdominal injury severity was dominated by hepatic injuries which remained as severe with Hexcel as the interface, although the probability of sustaining a renal laceration was three times lower with Hexcel. As seen in previous studies, the biomechanics of soft tissue injury appear to be dominated by the Viscous response.&lt;/div&gt;
Frequency-super-mixing in dielectric metasurfaces (2017)

Using III-V dielectric metasurfaces, we experimentally demonstrate resonantly enhanced nonlinear optical processes up to fifth-order including sum-frequency generation, four-wave mixing, 2nd-, 3rd-, and 4th-harmonic generations, etc., with spectra spanning the UV to the near-IR.
Comparison of AUC in clinical trials with follow up censoring: Application to HIV therapeutic vaccines (2020)

International audience
Synthesis of Densely Packaged, Ultrasmall Pt02 Clusters within a Thioether‐Functionalized MOF: Catalytic Activity in Industrial Reactions at Low Temperature (2018)

The gram-scale synthesis, stabilization, and characterization of well-defined ultrasmall subnanometric catalytic clusters on solids is a challenge. The chemical synthesis and X-ray snapshots of Pt<sup>0</sup><sub>2</sub> clusters, homogenously distributed and densely packaged within the channels of a metal-organic framework, is presented. This hybrid material catalyzes efficiently, and even more importantly from an economic and environmental viewpoint, at low temperature (25 to 140 °C), energetically costly industrial reactions in the gas phase such as HCN production, CO<sub>2</sub> methanation, and alkene hydrogenations. These results open the way for the design of precisely defined catalytically active ultrasmall metal clusters in solids for technically easier, cheaper, and dramatically less-dangerous industrial reactions.
A Virtual World Web Client Utilizing an Entity-Component Model (2013)

The popularity of virtual worlds has increased considerably in recent years. Currently, many service providers are trying to make it easier for users to access their virtual worlds. However, accessing a virtual world typically requires a client application that needs to be versioned for each device platform and operating system configuration. Using WebGL, an interactive 3D environment can be used on a cross-platform supported web browser. In this paper, we present a system architecture that utilizes an entity-component model, and a prototype implementation of a WebGL-based virtual world client to provide a plug-in free, extensible and open source web client for 3D virtual worlds. The performance of the web client was evaluated in terms of frame rate, CPU load, memory consumption and scene processing speed. Based on the results, the performance of the web client was good on a desktop PC, but mobile hardware specific optimizations are required to provide a good user experience on mobile devices.
Blade Plate Compared with Locking Plate for Tibiotalocalcaneal Arthrodesis: A Cadaver Study (2008)

Use of a locking plate may be an effective fixation technique in tibiotalocalcaneal arthrodesis, especially in complex hindfoot reconstructions with bone loss or deformity.
SELF-TESTING OF SIGMA-DELTA MEMS SENSORS USING BIMBO (2007)

International audience
Synthesis and characterization of novel amphiphilic block copolymers di-, tri-, multi-, and star blocks of PEG and PIB (2000)

A simple but efficient strategy has been developed for the synthesis of novel di-, tri-, multi-, and star-block copolymers comprising poly(ethylene glycol) (PEG) and polyisobutylene (PIB) blocks. The synthesis principle involves the coupling of appropriately terminally functionalized PEG and PIB sequences, specifically the hydrosilation of mono-, di-, and tetra-allyl-telechelic PEGs (PEG-allyl, allyl-PEG-allyl, and C(-PEG-allyl)4 by mono- and di-Si(CH3)2H telechelic PIBs (PIB-SiH and HiS-PIB-SiH). Representative block copolymers, for example, PEG-PIB, PIB-PEG-PIB, (-PIB-PEG-)n, and C(-PEG-PIB)4 have been assembled and their structures determined by 1H and 13C NMR spectroscopy. The bulk and surface morphology of select triblocks have been investigated by DSC and AFM and the findings interpreted in terms of phase-separated PEG and PIB microdomains. The swelling behavior in water of various block copolymers also has been studied. Block copolymers containing 50–70 wt % PIB produce hydrogels, the integrity of which is maintained by physical crosslinks by PIB segments. © 2000 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 38: 3200–3209, 2000
Decapod-inspired pigment modulation for active building facades (2022)

Typical buildings are static structures, unable to adjust to dynamic temperature and daylight fluctuations. Adaptive facades that are responsive to these unsteady solar conditions can substantially reduce operational energy inefficiencies, indoor heating, cooling, and lighting costs, as well as greenhouse-gas emissions. Inspired by marine organisms that disperse pigments within their skin, we propose an adaptive building interface that uses reversible fluid injections to tune optical transmission. Pigmented fluids with tunable morphologies are reversibly injected and withdrawn from confined layers, achieving locally-adjustable shading and interior solar exposure. Multicell arrays tiled across large areas enable differential and dynamic building responses, demonstrated using both experimental and simulated approaches. Fluidic reconfigurations can find optimal states over time to reduce heating, cooling, and lighting energy in our models by over 30% compared to current available electrochromic technologies.
An Evaluation of Real-Time Cognitive State Classification in a Harsh Operational Environment (2007)

This paper describes an evaluation conducted with a full platoon of 32 Soldiers at Aberdeen Proving Grounds' MOUT site in Aberdeen, MD. The objective was to assess the cognitive workload classification techniques driven by neuro-physiological (EEG) and physiological (ECG) sensors. In a first ever evaluation of real-time cognitive monitoring in the harsh operational environment, the assessment culminated in a three phase, 24-hour mission consisting of a coordinated Route Reconnaissance, a Cordon and Search of a village, and a Hasty Defense operation. Task load levels were manipulated by introducing unexpected and unplanned events requiring re-planning and extensive coordination by the leadership (high task load) as well as lulls in the activity in which part missions were executed flawlessly with little variations on the preplanned, well versed drill (low task load). Four leaders (Platoon Leader, Platoon Sergeant, Squad Leader 1, and Squad Leader 2) were equipped with sensors to measure and output cognitive state in real-time. The fused EEG and ECG workload classification approach reached 95% accuracy depending on the individual and the amount of data used to train the classifier. This level of success implies that Augmented Cognition workload assessment tools enable the ability to move beyond subjective workload rating scales, such as NASA TLX and Cooper Harper ratings, to more objective measurements of real-time cognitive state metrics in almost any conceivable operational environment.
Neuroblast protuberances in the subventricular zone of the regenerative MRL/MpJ mouse (2006)

The MRL mouse is unique in its capacity for regenerative healing of wounds. This regenerative ability includes complete closure, with little scarring, of wounds to the ear pinna and repair of cardiac muscle, without fibrosis, following cryoinjury. Here, we examine whether neurogenic zones within the MRL brain show enhanced regenerative capacity. The largest neurogenic zone in the adult brain, the subventricular zone (SVZ), lies adjacent to the lateral wall of the lateral ventricle and is responsible for replacement of interneuron populations within the olfactory bulb. Initial gross observation of the anterior forebrain in MRL mice revealed enlarged lateral ventricles; however, little neurodegeneration was detected within the SVZ or surrounding tissues. Instead, increased proliferation within the SVZ was observed, based on incorporation of the thymidine analogue bromodeoxyuridine. Closer examination using electron microscopy revealed that a significant number of SVZ astrocytes interpolated within the ependyma and established contact with the ventricle. In addition, subependymal, protuberant nests of cells, consisting primarily of neuroblasts, were found along the anterior SVZ of MRL mice. Whole mounts of the lateral wall of the lateral ventricle stained for the neuroblast marker doublecortin revealed normal formation of chains of migratory neuroblasts along the entire wall and introduction of enhanced green fluorescent protein-tagged retrovirus into the lateral ventricles confirmed that newly generated neuroblasts were able to track into the olfactory bulb.
Chromatography‐Free Multicomponent Synthesis of Thioureas Enabled by Aqueous Solution of Elemental Sulfur (2020)

The development of a new three-component chromatography-free reaction of isocyanides, amines and elemental sulfur allowed us the straightforward synthesis of thioureas in water. Considering a large pool of organic and inorganic bases, we first optimized the preparation of aqueous polysulfide solution from elemental sulfur. Using polysulfide solution, we were able to omit the otherwise mandatory chromatography, and to isolate the crystalline products directly from the reaction mixture by a simple filtration, retaining the sulfur in the solution phase. A wide range of thioureas synthesized in this way confirmed the reasonable substrate and functional group tolerance of our protocol.