gebhart/patrepeval huggingface dataset:
ABCG1 as a novel link between cholesterol homeostasis and tumor immunity (P2031) (2013)

Abstract ATP-binding Cassette Transporter G1 (ABCG1) promotes cholesterol efflux from cells for intracellular cholesterol homeostasis. ABCG1 has been shown to regulate macrophage and lymphocyte immune responses. In this study, we demonstrate a role of ABCG1 as a novel modulator of tumor immunity. MB49 bladder carcinoma or B16 melanoma cells were injected into Abcg1-/- or B6 mice subcutaneously. Both groups of mice were fed with either high-fat diet or chow diet starting a week before injection of tumor cells. Abcg1-/- mice on high-fat diet had dramatically reduced (80 %) tumor growth compared to B6 mice. Abcg1-/- mice on high-fat diet also showed diminished tumor metastasis and prolonged survival. Furthermore, we showed that reduced tumor size in Abcg1-/- mice on high-fat diet was associated with an increase in the frequency of NK cells and T cells and decrease in the frequency of macrophages and Tregs in tumor. Selective inhibition of ABCG1 in myeloid cells, but not in T cells, reduced tumor growth in vivo, demonstrating that impaired tumor growth in the absence of ABCG1 is mediated through myeloid cell-intrinsic factors. Moreover, ABCG1 deficiency caused an increase in apoptosis of macrophages and a shift of macrophages to an M1 phenotype in the tumor under high-fat diet conditions. Overall, our study shows that absence of ABCG1 inhibits tumor growth through regulation of macrophage function within the tumor and provides a link between diet, cholesterol homeostasis, and cancer.
Structural and electronic spectroscopic investigation of [(Me2N)3C3]2[Pt2Cl6] (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructural and electronic spectroscopic investigation of [(Me2N)3C3]2[Pt2Cl6]Charles D. Cowman, Jack C. Thibeault, Ronald F. Ziolo, and Harry B. GrayCite this: J. Am. Chem. Soc. 1976, 98, 11, 3209–3214Publication Date (Print):May 1, 1976Publication History Published online1 May 2002Published inissue 1 May 1976https://pubs.acs.org/doi/10.1021/ja00427a026https://doi.org/10.1021/ja00427a026research-articleACS PublicationsRequest reuse permissionsArticle Views102Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Comparison of electric field dependent activation energy for electroformation in TaO<inf>x</inf> and TiO<inf>x</inf> based RRAMs (2013)

Oxide based resistive switching memories are considered to be one of the front-runners for the next generation non-volatile memories. Forming, the critical one time programming process, is not well understood. In this work, we try to understand the dynamics of forming process in two model systems - TaO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> and TiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> , and compare the similarities and the universality in its control parameters. After comparing the time, voltage and temperature dependent dynamics, we find that a 1/E (E being electric field) dependence causes the activation energy to reduce by more than an order of magnitude.
Towards Confirming Neural Circuit Inference from Population Calcium Imaging (2015)

Vogelstein JT, Mishchenko Y, Packer AM, Machado TA, Yuste R, Paninski L. Towards Confirming Neural Circuit Inference from Population Calcium Imaging. Society forNeuroscience, 2009
Background memory management for dynamic data structure intensive processing systems (2002)

Telecommunication network management applications often require application-specific ICs that use large dynamically allocated stored data structures. Currently available hardware synthesis environments typically do not support dynamic data structure concepts and their associated memory synthesis problems. In this paper we address the background memory management task in a hardware design trajectory, which includes allocation of a distributed memory architecture, assignment and mapping of abstract data structures to memories, and synthesis of dynamic management behavior. With this approach to explore for the optimal memory architecture, the design entry point is lifted to a higher level than currently used for behavioral synthesis, as the specification can be a high-level program using data abstraction. The power of our approach will be substantiated on an industrial high-performance telecommunication ASIC design.
Pattern Recognition by Neural-Network Processing in the Combined Sratial-Orientational Space (2005)

A dual stage neural-network architecture is proposed, for the combined local and global processing of visual dot-patterns, in the spatial-orientational space. Dipoles defining local orientation are first determined by a Hopfield-type network. The second stage, consisting of a layered neural network, is then trained by the back propagation algorithm with a new cost function to discriminate between dipole patterns. The network performance in classification tasks is similar to that of human vision.
Bronchiolitis associated with respiratory syncytial virus (1997)

L'observation L'enfant I.A., 12 jours, est hospitalise du 10 au 19 novembre dans le service de medecine neonatale pour une bronchoalveolite. La veille il avait presente un encombrement rhinopharynge avec toux et des difficultes alimentaires. A son entree dans le service, l'examen clinique met en evidence un tirage intercostal sus-sternal, une toux seche sans cyanose. L'auscultation retrouve des sibilants diffus avec des crepitants. La saturation transcutanee a l'air ambiant est de 93 %. Les mesures des gaz du sang realisees a l'entree sont les suivantes : pH = 7,30 ; PCO2 = 58 ; BE = + 1. Le bilan de coagulation et de biochimie, la proteine reactive C (CRP) et l'hemogramme sont normaux. La radiographie du thorax suggere le diagnostic d'alveolite. La detection positive d'antigenes du virus respiratoire syncytial (VRS) par immunofluorescence indirecte dans les secretions rhinopharyngees identifie l'agent responsable de ce tableau de bronchoalveolite. La prise en charge therapeutique comporte une kinesitherapie respiratoire, trois fois par jour au debut, puis une fois par jour, associee a une antibiotherapie par Augmentin® jusqu'au 19 novembre, date de sortie. Une seance par jour de kinesitherapie respiratoire pendant cinq jours est prescrite.
ChemInform Abstract: Iterative Assembly of Glycals and Glycal Derivatives: Synthesis of Glycosylated Natural Products and Complex Oligosaccharides (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Multistage High-Order Microring-Resonator Filters with a Wide FSR, Low Drop Loss and 30db in-Band Extinction (2005)

We demonstrate that add/drop filter designs comprising cascaded coupled-microring stages permit reduced drop-loss and relaxed tolerances for high through-port extinction. We report on high-index-contrast filters with 20nm FSR, 2.5dB drop loss and 30dB of extinction.
Algorithmes du type gradient à complexité de calcul réduite et à capacité de poursuite et vitesse de convergence accrues : application à l'annulation d'écho acoustique (1991)

Cette these concerne l'amelioration de l'algorithme lms, aussi bien en ce qui concerne son temps de calcul que son comportement adaptatif grace a une nouvelle formulation par bloc. Dans un premier temps, nous montrons comment diminuer le nombre d'operations du lms sans aucune approximation et en travaillant par bloc. Nous donnons deux versions rapides (temporelle-felms et frequentielle-fd-felms). La comprehension de cette formulation par bloc nous permet ensuite d'ameliorer le comportement adaptatif (vitesse de convergence et capacite de poursuite) des algorithmes du type lms. Nous proposons, ainsi, trois nouveaux algorithmes dont nous detaillons les proprietes. Tous les algorithmes obtenus ont ete compares a des algorithmes classiques tels que le lms et le frls dans une situation reelle, a savoir: l'identification d'une reponse impulsionnelle acoustique de salle, d'une part en presence d'une non-stationnarite dans le systeme, et d'autre part avec des signaux non-stationnaires en entree (parole). Pour terminer, nous montrons que les techniques developpees dans le cas du lms s'appliquent a d'autre types d'algorithmes tel que le cma qui semble etre un bon candidat pour l'egalisation aveugle
Rayleigh backscattering from the fundamental mode in step-index multimode optical fibers (2017)

The Rayleigh backscattering produced by an incident fundamental mode in a multimode step-index optical fiber was analyzed using a recently developed diffraction technique. The complete set of backward propagating modes, both radial and azimuthal, was determined and regarded. For this type of fiber, normalized mode functions were constructed in an explicit form, thus providing a unified power scale to characterize the relationships between various excited modes. The dependencies of the mode excitation efficiencies on the technical parameters of the fiber and the frequency of the launched radiation were studied. A comparison of the mode excitation efficiencies was performed with those in the fiber with quadratic refractive index profiles.
Crosslinked polymer materials for nonlinear optics. 2. Polyurethanes bearing azobenzene dyes (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCrosslinked polymer materials for nonlinear optics. 2. Polyurethanes bearing azobenzene dyesJ. A. F. Boogers, P. T. A. Klaase, J. J. de Vlieger, and A. H. A. TinnemansCite this: Macromolecules 1994, 27, 1, 205–209Publication Date (Print):January 1, 1994Publication History Published online1 May 2002Published inissue 1 January 1994https://pubs.acs.org/doi/10.1021/ma00079a030https://doi.org/10.1021/ma00079a030research-articleACS PublicationsRequest reuse permissionsArticle Views253Altmetric-Citations57LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Die Spaltung von Osteopontin durch MMP–7 verändert die Interaktion zwischen zytotoxischen T-Zellen und HepG2-Zellen (2005)

MMP–7, das kleinste Mitglied aus der Familie der Metalloproteasen, ist eine Zink-abhängige Protease, die im Hepatozellulären Karzinom und anderen humanen Tumoren exprimiert wird. Neben dem Einfluss auf die Progression und Metastasierung von Tumoren spielt MMP–7 eine fundamentale Rolle im frühen Stadium der Tumorentstehung. Die genauen Mechanismen sind bisher jedoch nicht geklärt.
Photo-Actuation Stress of Ultra-Drawn, Chain-Extended Polyethylene (2021)

The influence of solid-state drawing on the photo-actuation stress of oriented semi-crystalline polymers is explored experimentally and theoretically. Photo-responsive and ultra-drawn linear polyethylenes (PEs) containing a commercial benzotriazole dye (BZT) are studied as a model material. In accordance with previous studies, it is found that the actuation stress as a function of draw ratio exhibits an optimum and that the stress first increases and then decreases again slightly. A semi-empirical model is presented that describes the photo-actuation stress as a function of the draw ratio, Young’s modulus, thermal expansion coefficient, and temperature difference between the illuminated and non-illuminated state. The Young’s modulus and thermal expansion coefficient versus draw ratio curves are described using models based on the pseudo-affine deformation scheme in combination with a two-phase structural model in which highly oriented elements are connected in series with a disordered phase. Rather surprisingly, it is found that the model predicts that the photo-actuation stress is virtually independent of the draw ratio and the degree of chain orientation and extension. An excellent agreement is observed between model predictions and experimental results if the actuation stress is corrected for temperature effects related to the conversion of light into heat. The structure–property relationships derived here provide guidelines for the design of light-driven artificial muscle systems based on ultra-drawn polymers. For instance, it is predicted that ultra-drawn polyamides and polyesters are potentially excellent candidates for producing photo-actuators provided that suitable additives are used and this despite their low maximum attainable draw ratio, Young’s modulus and strength.
Synthesis of 9-[cis-3-(hydroxymethyl)cyclobutyl]-adenine and -guanine (1995)

2,2-Dichloro-3-(benzyloxymethyl)cyclobutanone 15, which was prepared in 50% yield by the cycloaddition of dichloroketene to allyl benzyl ether 14, was converted in four steps and in ∼ 40% overall yield into trans-3-(benzyloxymethyl)cyclobutanol 11b. The latter alcohol 11b was coupled under Mitsunobu conditions with 6-(4-chlorophenylsulfanyl)-9H-purine 21b and 6-(4-chlorophenylsulfanyl)-2-(phenylacetamido)-9H-purine 21c to give the 9-cyclobutylpurine derivatives 22 and 24, respectively, in 88 and 60% yield. The former product 22 was converted in three steps and in 39% overall yield into 9-[cis-3-(hydroxymethyl)cyclobutyl]adenine 6, and the latter product was converted in four steps and in 42% overall yield into 9-[cis-3-(hydroxymethyl)cyclobutyl]guanine 7. X-Ray crystallographic data relating to compounds 22 and 24 are also reported.
A Mobile Alert System for Preparing the Delivery of Radiation Mitigators. (2016)

Our observations suggest this mobile system is a potential pre-hospital arrival tool allowing for rapid preparation of radiation mitigators.
Toward a common semantics between media and languages (2006)

For a computer to recognize objects, persons, situations or actions in multimedia, it needs to have learned models of each thing beforehand. For the moment, no large, general collection of training examples exists for the wide variety of things that we would want to automatically recognize in multimedia, video and still images. We believe that the WWW and current technology can allow us to automatically build such a resource. This paper describes a methodology for the construction of a grounded, general purpose, multimedia ontology that is instantiated through web processing. In this hierarchically organized ontology, concepts corresponding to concrete objects, persons, situations and actions are linked with still images, videos and sounds that represent exemplars of each concept. These examples are necessary resources for computing discriminating signatures for the recognition of the concepts in still images or videos. Since images retrieved using existing image search engines contain much noise hand are not always representative, we also present here our methodology for finding good representative for each concept.
Strategies for Reduced NOx Emissions in Pilot-Ignited Natural Gas Engines (2003)

The performance and emissions of a single-cylinder natural gas fueled engine using a pilot ignition strategy have been investigated. Small diesel pilots (2–3% on an energy basis), when used to ignite homogeneous natural gas-air mixtures, are shown to possess the potential for reduced NOx emissions while maintaining good engine performance. The effects of pilot injection timing, intake charge pressure, and charge temperature on engine performance and emissions with natural gas fueling were studied. With appropriate control of the above variables, it was shown that full-load engine-out brake specific NOx emissions could be reduced to the range of 0.07–0.10 g/kWh from the baseline diesel (with mechanical fuel injection) value of 10.5 g/kWh. For this NOx reduction, the decrease in fuel conversion efficiency from the baseline diesel value was approximately one to two percentage points. Total unburned hydrocarbon (HC) emissions and carbon monoxide (CO) emissions were higher with natural gas operation. The nature of combustion under these conditions was analyzed using heat release schedules predicted from measured cylinder pressure data. The importance of pilot injection timing and inlet conditions on the stability of engine operation and knock are also discussed.
ChemInform Abstract: Ring Transformation of 4‐Amino‐1H‐1,5‐benzodiazepine‐3‐carbonitrile and Ethyl 4‐Amino‐1H‐1,5‐benzodiazepine‐3‐carboxylate into Benzimidazole Derivatives with Amines. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Sensor Based on a Poly[2-(Dimethylamino)ethyl Methacrylate-Co-Styrene], Gold Nanoparticles, and Methylene Blue-Modified Glassy Carbon Electrode for Melamine Detection (2021)

Melamine has been used as a non-protein nitrogenous additive in food products to artificially increase the apparent "false" protein content. Melamine is known as a dangerous and poisonous substance for human health and it causes diverse diseases. An electrochemical sensor for melamine detection has been developed by modification of a glassy carbon electrode using copolymer poly[DMAEMA-<i>co</i>-styrene], gold nanoparticles, and methylene blue. The characterization of the modified electrode was conducted using several analysis techniques including cyclic voltammetry (CV), differential pulse voltammetry (DPV), chronoamperometry (CA), and electrochemical impedance spectroscopy (EIS). The electrochemical detection of melamine was performed by impedance spectroscopy. Obtained results revealed that the developed sensor has a large detection range from 5.0 × 10<sup>-13</sup> to 3.8 × 10<sup>-8</sup> M with a low detection limit of 1.8 × 10<sup>-12</sup> M (at S/N = 3). Various interfering species such as phenol, hydroquinone, and bisphenol A have been used and their behavior on modified electrode has been studied.
Technique to reheat cores improves analysis (1991)

This paper reports on a temperature-compensated gas measurement technique which reheats coalbed methane cores to downhole temperature, thereby allowing more accurate gas measurements. With the cores at bottom hole pressure and temperature, the true volume and nature of gas can be measured to help predict overall coal seam gas reserves with much greater accuracy.
From Protein Complexes to Subunit Backbone Fragments: A Multi-stage Approach to Native Mass Spectrometry (2013)

Native mass spectrometry (MS) is becoming an important integral part of structural proteomics and system biology research. The approach holds great promise for elucidating higher levels of protein structure: from primary to quaternary. This requires the most efficient use of tandem MS, which is the cornerstone of MS-based approaches. In this work, we advance a two-step fragmentation approach, or (pseudo)-MS(3), from native protein complexes to a set of constituent fragment ions. Using an efficient desolvation approach and quadrupole selection in the extended mass-to-charge (m/z) range, we have accomplished sequential dissociation of large protein complexes, such as phosporylase B (194 kDa), pyruvate kinase (232 kDa), and GroEL (801 kDa), to highly charged monomers which were then dissociated to a set of multiply charged fragmentation products. Fragment ion signals were acquired with a high resolution, high mass accuracy Orbitrap instrument that enabled highly confident identifications of the precursor monomer subunits. The developed approach is expected to enable characterization of stoichiometry and composition of endogenous native protein complexes at an unprecedented level of detail.
EXPLORING DYNAMICAL EFFECTS OF BEND EXCITATION ON THE Cl + CH$_4$ REACTION (2005)

{Present address: Department of Chemistry; Massachusetts Institute of Technology; Cambridge; MA 02139
Fiber amplifiers under thermal loads leading to transverse mode instability (2014)

Transverse mode instability (TMI) in rare-earth doped fiber amplifiers operating above an average power threshold is caused by intermodal stimulated thermal Rayleigh scattering due to quantum defect heating. We investigate thermally induced longitudinal waveguide perturbations causing power transfer from the fundamental mode (FM) to the higher order mode (HOM) by a nonlinear gain, which depends on the FM-HOM frequency shift and position along the fiber. We take temperature and mode profile evolution along the fiber into consideration to engineer fiber designs with increased TMI threshold and operation stability at higher average powers.
Diode-pumped 214.8-nm Nd:YAG/Cr4+:YAG microchip-laser system for the detection of NO (2001)

A passively (2-switched Nd:YAG/Cr4+:YAG microchip laser at 214.8-nm (46556 cm−1, the fifth harmonic of 1.074-µm) was developed. NO was detected by laser-induced fluorescence at a sensitivity of −15 ppbv in a simple, compact optical system.
CCDC 1054956: Experimental Crystal Structure Determination (2017)

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.