gebhart/patrepeval huggingface dataset:
Joint interference coordination and relay cell expansion in LTE-Advanced networks (2012)

Deploying relay nodes is foreseen a cost-efficient solution to combat the severe propagation loss at cell edge. However, relay cell coverage is limited by the low transmit power, limited antenna capabilities and wireless backhaul link bottleneck which may lead to load imbalances and hence low resource utilization efficiency. Further challenges in relay deployments are attributed to increased interference levels in the network compared with macrocell-only deployments, causing degradation of the user throughput. In this context, relay cell coverage expansion and interference coordination techniques are expected to improve the performance of relay deployments. In this study, we analyze the impact of the additional interference due to the relay node transmissions. Jointly with our previous study on cell expansion, we show how the interference coordination mitigates the interference from relays and hence optimizes the system performance. Comprehensive system level simulations are carried out within the LTE-Advanced framework. Results confirm that the interference imposed by relay nodes can be reduced. Furthermore, both cell edge throughput gains and cell average throughput gains are observed.
Study of a polarimetric model for diffuse scattering in urban environment (2012)

This work focuses on the polarimetric properties of radio waves scattered off building walls. Two measurement campaigns, the first in a street canyon scenario and the second in a campus scenario, are used to validate an ad-hoc polarimetric diffuse scattering model, suitable to be embedded in Ray-Tracing (RT) prediction tools. The polarization part of the model relies on a single parameter, K <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">xpol</sub> , that sets the polarization coupling between the original polarization and the orthogonal one, caused by a scattering interaction. Results show that between 20% and 30% of the incident field intensity is depolarized, depending on the scenario, in accordance with what found in the experimental parametrization of the model.
Lymphatic endothelial cells induce anergy of β-galactosidase specific CD4 T cells by providing antigen to CD11c cells (P1147) (2013)

Abstract Lymphatic endothelial cells (LEC) express a variety of peripheral tissue antigens (Ags) and induce deletional tolerance of tyrosinase-specific CD8 T cells. LEC express MHC II molecules, suggesting they may tolerize CD4 T cells. We expressed β-galactosidase (β-gal) selectively in LEC using Lyve-1cre x β-galflox mice to investigate the ability of LEC to tolerize β-gal specific CD4 and CD8 T cells (Bg2 and Bg1, respectively). Using in vitro co-cultures and MHC I-/- bone marrow chimeras, we demonstrated that Bg1 CD8 T cells undergo deletional tolerance after recognizing Ag presented by MHC I molecules on LEC. Peptide-pulsed LEC induce Bg2 CD4 T cell proliferation in vitro, indicating LEC express functional MHC II. However, Bg2 cells proliferate when co-cultured with CD11c cells but not with LEC from β-gal+ mice. When Ag presentation is restricted to LEC in MHC II-/- bone marrow chimeras, Bg2 cells do not proliferate or upregulate CD69, CD25 or CD44. However, Bg2 cells do proliferate when transferred into chimeras with MHC II+ β-galneg bone marrow, demonstrating that hematopoietic cells acquire and present Ag from LEC. Bg2 cells activated in vivo by hematopoietic presentation of LEC-derived Ag do not proliferate in response to subsequent rechallenge, demonstrating that they have become anergic. Thus, LEC show a diminished ability to directly present MHC II Ags, but play an important role in CD4 tolerance by serving as a reservoir of Ag used by hematopoietic cells to induce anergy.
Claudin-1 Acts through c-Abl-Protein Kinase Cδ (PKCδ) Signaling and Has a Causal Role in the Acquisition of Invasive Capacity in Human Liver Cells (2009)

Claudins are identified as members of the tetraspanin family of proteins, which are integral to the structure and function of tight junction. Recent studies showed an increase in expression of claudins during tumorigenesis, which is associated with loss of cell-cell contact, dedifferentiation, and invasiveness. However, the molecular basis for the causal relationship between claudin expression and cancer progression is not fully understood yet. In this study, we show that claudin-1 plays a causal role in the acquisition of invasive capacity in human liver cells and that c-Abl-protein kinase Cdelta (PKCdelta) signaling is critical for the malignant progression induced by claudin-1. Overexpression of claudin-1 clearly induced expression of matrix metalloproteinase-2 (MMP-2) and cell invasion and migration in normal liver cells as well as in non-invasive human hepatocellular carcinoma (HCC) cells. Conversely, small interfering RNA targeting of claudin-1 in invasive HCC cells completely inhibited cell invasion. Both c-Abl and PKCdelta are found to be activated in normal liver cell line clones that stably overexpress claudin-1. Inhibition of either c-Abl or PKCdelta alone clearly attenuated MMP-2 activation and impeded cell invasion and migration in both human HCC and normal liver cells expressing claudin-1. These results indicate that claudin-1 is both necessary and sufficient to induce invasive behavior in human liver cells and that activation of c-Abl-PKCdelta signaling pathway is critically required for the claudin-1-induced acquisition of the malignant phenotype. The present observations raise the possibility of exploiting claudin-1 as a potential biomarker for the spread of liver cancer and might provide pivotal points for therapeutic intervention in HCC.
A hardware and software system for MRI applications requiring external device data (2022)

The performance of the system and its versatile architecture make it suitable for a wide range of MRI applications requiring online or offline use of external device data.
Influence of Carbides Precipitated by Low-temperature Tempering on the Room-temperature Mechanical Properties of Grade 91 Steel (2022)

The precipitation behavior of carbides in modified 9Cr-1Mo steel (Grade 91) subjected to low-temperature tempering and the influence of those carbides on the mechanical properties at room temperature were investigated. An as-quenched sample (AQ) contained a small amount of metal carbide (MC) in its martensite microstructure. On low-temperature tempering at 300–500°C, intended to suppress the recovery and growth of the dislocation substructure, three types of carbide were formed; these were identified as Fe4C, hP8-type Fe3C, and oP16-type Fe3C by using replica samples for transmission electron microscopy and extracted-residue analyses. Samples subjected to double low-temperature tempering at 500°C for 5 min and then at 300°C for 1 h (DLTT) contained large amounts of carbide compared with the AQ sample, but had similar a lath width. The hardness of the DLTT sample was higher than that of the AQ sample, whereas its tensile strength was slightly lower than that of the AQ sample, regardless of the strain rate. The reason that precipitation strengthening did not increase tensile strength is considered to be the early formation of microvoids due to delamination at the carbide/matrix interfaces during tensile testing.
Light propagation and local speed in the linear Sagnac effect (2019)

We investigate rigorously the behaviour of light propagation in the closed contour of the linear Sagnac effect. Assuming that the local light speed is c in a section of the contour, our approach ma...
Micro-organism extraction from biological samples using DEP forces enhanced by osmotic shock (2012)

On the road towards efficient diagnostics of infectious diseases, sample preparation is considered as the key step and remains a real technical challenge. Finding new methods for extraction of micro-organisms from a complex biological sample remains a major challenge prior to pathogen detection and analysis. This paper reports a new technique for capturing and isolating micro-organisms from a complex sample. To achieve the segregation of pathogens and blood cells, dielectrophoretic forces applied to bioparticles previously subjected to an osmotic shock are successfully implemented within a dedicated microfluidic device. Our device involves an electrode array of interdigitated electrodes, coated with an insulating layer, to minimize electrochemical reactions with the electrolyte and to enable long-time use. The electric field intensity inside the device is optimized, considering the insulating layer, for a given frequency bandwidth, enabling the separation of bioparticles by dielectrophoretic forces. Our predictions are based on analytical models, consistent with numerical simulations (using COMSOL Multiphysics) and correlated to experimental results. The method and device have been shown to extract different types of micro-organisms spiked in a blood cell sample. We strongly believe that this new separation approach may open the way towards a simple device for pathogen extraction from blood and more generally complex samples, with potential advantages of genericness and simplicity.
Microelectrode Array Fabrication by Electrical Discharge Machining and Chemical Etching (2004)

Wire electrical discharge machining (EDM), with a complementary chemical etching process, is explored and assessed as a method for developing microelectrode array assemblies for intracortically recording brain activity. Assembly processes based on these methods are highlighted, and results showing neural activity successfully recorded from the brain of a mouse using an EDM-based device are presented. Several structures relevant to the fabrication of microelectrode arrays are also offered in order to demonstrate the capabilities of EDM.
Trajectories of Clinical and Laboratory Characteristics Associated with COVID-19 in Hemodialysis Patients by Survival (2021)

Abstract Introduction The clinical impact of COVID-19 has not been established in the dialysis population. We evaluated the trajectories of clinical and laboratory parameters in hemodialysis (HD) patients. Methods We used data from adult HD patients treated at an integrated kidney disease company who received a RT-PCR test to investigate suspicion of a SARS-CoV-2 infection between 01 May and 01 Sep 2020. Nonparametric smoothing splines were used to fit data for individual trajectories and estimate the mean change over time in patients testing positive or negative for SARS-CoV-2 and those who survived or died within 30 days of first suspicion or positive test date. For each clinical parameter of interest, the difference in average daily changes between COVID-19 positive versus negative group and COVID-19 survivor versus non-survivor group was estimated by fitting a linear mixed effects model based on measurements in the 14 days before (i.e., day-14 to day 0) day 0. Results There were 12,836 HD patients with a suspicion of COVID-19 who received RT-PCR testing (8,895 SARS-CoV-2 positive). We observed significantly different trends (p&lt;0.05) in pre-HD systolic blood pressure (SBP), pre-HD pulse rate, body temperature, ferritin, lymphocytes, albumin, and interdialytic weight gain (IDWG) between COVID-19 positive and negative patient. For COVID-19 positive group, we observed significantly different clinical trends (p&lt;0.05) in pre-HD pulse rate, lymphocytes, albumin and neutrophil-lymphocyte ratio (NLR) between survivors and non-survivors. We also observed that, in the group of survivors, most clinical parameters returned to pre-COVID-19 levels within 60-90 days. Conclusion We observed unique temporal trends in various clinical and laboratory parameters among HD patients who tested positive versus negative for SARS-CoV-2 infection and those who survived the infection versus those who died. These trends can help to define the physiological disturbances that characterize the onset and course of COVID-19 in HD patients
51 CYP2D6 PHENOTYPING BY AN AUTOMATED DETERMINATION OF DEXTROMETHORPHAN AND ITS MAIN METABOLITES IN HUMAN PLASMA (1995)

Härtter, S.; Hiemke, C.; Ziegler, G.; Bauer, J.; Frei-Ziegler, S.; Baier, D.; Dingemanse, J. Author Information
Development of a Village-Scale, Solar-Powered Reverse Osmosis System (2016)

This paper details the development of a photovoltaic reverse osmosis water desalination system for a groundwater well in Bercy, Haiti. The well was constructed to provide potable drinking and agricultural water for the 300-person community. However, its water has a salinity level of 5,290 ppm, rendering it harmful for both human consumption and soil fertility. This reverse osmosis system is designed to be low-cost and operational off-grid while providing 900 gallons per day of desalinated water for the community. The system is composed of a photovoltaic power system, a submersible solar pump, and three reverse osmosis membranes. The system is designed to have a material cost significantly below that of any commercially-available system of similar scale. Furthermore, it has an average water production cost of $1.21/m3 and an average specific energy of 1.2 kWh/m3. Its performance was tested in the laboratory by connecting the desalination module to a DC power supply, demonstrating good agreement with its modeled performance. The installation of the full system with the PV module will take place on-site in the summer of 2016. Following implementation, the system will be monitored and compared against predicted performance. The first attempt is meant to serve as a verification and validation of the system as a whole. However, successful operation within the given cost target could pave the way for wider use of off-grid reverse osmosis systems at many remote locations with limited freshwater access around the world.
Current and emerging biologics for the treatment of hereditary angioedema (2019)

The advent of biologic therapies dramatically improved the lives of patients with C1-INH-HAE although further improvement is still needed. Whether this is cost/effective will be answered in the next years when we will see if these major advances will benefit the majority of the patients.
Alibi Routing (2015)

There are several mechanisms by which users can gain insight into where their packets have gone, but no mechanisms allow users undeniable proof that their packets did not traverse certain parts of the world while on their way to or from another host. This paper introduces the problem of finding "proofs of avoidance": evidence that the paths taken by a packet and its response avoided a user-specified set of "forbidden" geographic regions. Proving that something did not happen is often intractable, but we demonstrate a low-overhead proof structure built around the idea of what we call "alibis": relays with particular timing constraints that, when upheld, would make it impossible to traverse both the relay and the forbidden regions. We present Alibi Routing, a peer-to-peer overlay routing system for finding alibis securely and efficiently. One of the primary distinguishing characteristics of Alibi Routing is that it does not require knowledge of--or modifications to--the Internet's routing hardware or policies. Rather, Alibi Routing is able to derive its proofs of avoidance from user-provided GPS coordinates and speed of light propagation delays. Using a PlanetLab deployment and larger-scale simulations, we evaluate Alibi Routing to demonstrate that many source-destination pairs can avoid countries of their choosing with little latency inflation. We also identify when Alibi Routing does not work: it has difficulty avoiding regions that users are very close to (or, of course, inside of).
Telepresence across the Ocean (2010)

We describe the development and deployment of a system for long-distance remote observation of robotic operations. The system we have developed is targeted to exploration, multi-participant interaction, and tele-learning. In particular, we used this system with a robot deployed in an underwater environment in order to produce interactive web-casts of scientific material. The system used a combination of robotic and networking technologies and was deployed and evaluated in a context where students in a classroom were able to observe and participate to a limited degree in the operation of a distant robot being used for environmental assessment.
EGFR-Targeted Granzyme B Expressed in NK Cells Enhances Natural Cytotoxicity and Mediates Specific Killing of Tumor Cells (2013)

Natural killer (NK) cells are highly specialized effectors of the innate immune system that hold promise for adoptive cancer immunotherapy. Their cell killing activity is primarily mediated by the pro-apoptotic serine protease granzyme B (GrB), which enters targets cells with the help of the pore-forming protein perforin. We investigated expression of a chimeric GrB fusion protein in NK cells as a means to augment their antitumoral activity. For selective targeting to tumor cells, we fused the epidermal growth factor receptor (EGFR) peptide ligand transforming growth factor a (TGFa) to human pre-pro-GrB. Established human NKL natural killer cells transduced with a lentiviral vector expressed this GrB-TGFa (GrB-T) molecule in amounts comparable to endogenous wildtype GrB. Activation of the genetically modified NK cells by cognate target cells resulted in the release of GrB-T together with endogenous granzymes and perforin, which augmented the effector cells' natural cytotoxicity against NK-sensitive tumor cells. Likewise, GrB-T was released into the extracellular space upon induction of degranulation with PMA and ionomycin. Secreted GrB-T fusion protein displayed specific binding to EGFRoverexpressing tumor cells, enzymatic activity, and selective target cell killing in the presence of an endosomolytic activity. Our data demonstrate that ectopic expression of a targeted GrB fusion protein in NK cells is feasible and can enhance antitumoral activity of the effector cells.
Molecular characterization of class 1 integrons in clinical strains of Salmonella typhimurium isolated in Slovakia. (2007)

The presence of class 1 integrons was investigated in 156 epidemiologically unrelated Salmonella Typhimurium isolates. Of these 156 isolates, 70 were of definitive phage type DT104 and 86 were strains of various phage type, RDNC and untypable, designated here as non-DT104 strains. Integrons were found in 47 of DT104 isolates (67.1%), while in all strains with characteristic pentaresistance (R-type ACSSuT) two integrons 1.0 kb and 1.2 kb in size were found. Among 86 non-DT104 strains, integrons with sizes of 1.6 kb and 1.9 kb in four multidrug-resistant strains DT193 and U302 were found. The integrons from selected strains were further sequenced and the aadA1, aadA2, dhfr1, dhfr12 and bla(PSE) genes were found embedded in cassettes.
Comparison of CGH Testing To CMM Point Cloud Measurements for Freeform Surfaces (2013)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text R. Johnston and J. M. Tamkin, "Comparison of CGH Testing To CMM Point Cloud Measurements for Freeform Surfaces," in Renewable Energy and the Environment: Postdeadline Papers, OSA Postdeadline Paper Digest (online) (Optica Publishing Group, 2013), paper FW2B.7. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Supplementary Figure S2 from Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance (2023)

&lt;p&gt;Supplementary Figure S2. Correlation between plasma RTK changes with MAPKi, PFS, and initial tumor shrinkage (using RECIST) in melanoma patients.&lt;/p&gt;
Bone Marrow Mastocytosis Associated with IgM Kappa Plasma Cell Myeloma (2003)

An association between mastocytosis and monoclonal gammopathy is a relatively rare but well recognized clinical finding. In the majority of cases, however, overt myeloma or lymphoma is not detectable morphologically. Here we describe the case of a 51 year-old male patient first presenting with paresis of the right facial nerve and the serological finding of IgM kappa paraproteinemia. The patient did not have organomegaly, lytic bone lesions, or urticaria pigmentosa-type skin lesions. Histological examination of a trephine biopsy specimen revealed the unusual coexistence of plasma cell myeloma and mastocytosis. Immunohistochemically, plasma cells were found to exhibit a monotypic staining for Ig heavy chain mu and Ig light chain kappa, thus confirming their neoplastic nature. Mast cells showed prominent spindling and formed dense multifocal infiltrates, thus enabling the diagnosis of bone marrow mastocytosis. Immunohistochemically, mast cells expressed tryptase, chymase, and KIT (CD117). In addition, aberrant expression of CD25 on mast cells was detected, confirming the coexistence of a neoplastic mast cell-proliferative disorder. According to the WHO proposal for classification of hematopoietic malignancies, this unique case, showing the association of two very rare haematologic neoplasms, can therefore best be referred to as bone marrow mastocytosis associated with IgM kappa plasma cell myeloma (SM-AHNMD).
Adenosine Triphosphate Production by Bovine Spermatozoa and Its Relationship to Semen Fertilizing Ability (2008)

This article's objectives are to investigate the relationship between adenosine triphosphate (ATP) production (oxidative phosphorylation and glycolysis) and fertility of bovine spermatozoa, determine the proportion of oxygen consumption devoted to proton leak and that due to nonmitochondrial processes, and discover whether freeze/thawing affects sperm oxygen consumption. Oxygen consumption of bovine spermatozoa was measured using a standard Clark electrode and, for the first time, in an Oxygen Biosensor System (OBS). Total ATP formation by bovine spermatozoa was calculated from the oxygen consumption and lactate production (glycolysis) by the same spermatozoa sample. ATP production varied from 1.99 to 8.09 mumol ATP per 10(8) spermatozoa per hour; glycolysis accounted for 16% to 38% of ATP. Nonmitochondrial oxygen consumption could not be detected in bovine spermatozoa using these methods. A significant proportion (16%-43%) of oxygen consumption was insensitive to oligomycin and was due to "proton leak." There was no significant difference between oxygen consumption of frozen/thawed and fresh spermatozoa for 2 of the 3 bulls tested. However, oxygen consumption of frozen/thawed spermatozoa was significantly higher (P < .05) than fresh spermatozoa for the third bull. When ZO(2) of frozen/thawed spermatozoa from 20 bulls was compared with their 49 day nonreturn rates (NRRs), oxygen consumption was correlated positively with NRR (ie, fresh spermatozoa with a higher ZO(2) were more fertile). Moreover, total ATP production correlated with NNR better than ZO(2). Bulls with a lower NRR produce spermatozoa that are susceptible to damage during the freeze/thawing process, causing an increase in ZO(2), possibly due to mitochondrial membrane damage resulting in more energy being expended in maintaining the proton gradient, or capacitation-like changes causing hyperactivation. Oxygen consumption measured in the OBS may be useful in assessing bovine sperm fertility.
Selective Alkylation of a 6,7‐Dihydroxyquinazoline. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access the actual ChemInform Abstract, please click on HTML or PDF.