gebhart/patrepeval huggingface dataset:
On Orbit Performance of the Defense Meteorological Satellite Program (DMSP) 5D3 Spacecraft Power System (2011)

Abstract : This report provides an analysis of the orbital performance of the three DMSP 5D3 spacecraft presently on orbit. The mission of the DMSP spacecraft is to collect and disseminate global high-resolution visible and thermal cloud cover imagery for DoD forces and the intelligence community. The present two-satellite constellation (early morning and mid morning) has an inclination of 98.7 with a 458 nmi sun synchronous polar orbit. The orbit period is I0l min with eclipses lasting up to 35 min. The satellites complete 14.2 revolutions around the Earth each day. The report presents data from the satellite telemetry that will allow determination of the spacecraft power demand for the range of sun angles and spacecraft configurations for the three operational 5D3 spacecraft. This is used in determining spacecraft energy balance margins under various operating conditions.
The Receptor with High Affinity for IgE (2007)

The cDNAs for each of the three types of polypeptide that form the high affinity IgE receptor have been cloned and sequenced. Analysis of the predicted amino acid sequence and other data suggests that the four-chained structure (alpha beta gamma 2) contains seven transmembrane segments. The alpha chain resembles the immunoglobulin-binding chain found in other Fc receptors, but the beta and gamma chain sequences do not resemble other known proteins. (The one exception: the transmembrane segment of the gamma chains, which is homologous to the corresponding segment of the zeta chain of the CD3 complex found on T lymphocytes). Efficient expression of IgE binding by the rat receptor in COS cells was observed only when the coding sequences for each of the three chains were co-transfected. So far, only the cDNA for the human alpha chain has been successfully cloned. We attempted to express this chain by co-transfecting its cDNA with those for the rat beta and gamma chains. Surprisingly, co-transfection with the cDNA for the gamma chain was sufficient, although when the beta and gamma chains were both co-transfected, expression of alpha beta gamma oligomers was evident. Approaches being used to define by genetic manipulation the functional role of various parts of the receptor are discussed.
DIFFERENT EFFECTS OF 3 NEGATIVE ALLOSTERIC MODULATORS OF G‐PROTEIN COUPLED HUMAN Ca2+ RECEPTOR (2006)

The human Ca2+ receptor (hCaR) plays a central role in the regulation of extracellular Ca2+ homeostasis. How calcium binding to the extracellular domain leads to activation of the seven-transmembrane domain (7TM) of the receptor is a major unresolved question. Synthetic allosteric modulators of the hCaR targeting the 7TM not only have therapeutic potential but also offer insights into the mechanism of receptor activation. We reported earlier that residue E837 in the 7TM of the receptor plays a pivotal role in the action of structurally related positive modulator NPS R-568 and negative modulator NPS 2143. We speculated that acidic side-chain of E837 forms a critical salt bridge with the positively charged amino group centered in these phenylalkylamines. Recently a novel negative modulator, BMS Compound 1, was reported which shows a unique structure with no positively charged central amine. Our results show that Compound 1 remains capable of negative modulation of the E837A mutant. We further synthesized a novel compound, “JKJ 05”, which is structurally related to Compound 1 but carries a positively charged primary amine. We found that JKJ 05 is also a negative modulator of the wild type hCaR, but less potent than Compound 1. However, very interestingly, JKJ 05 increases calcium response by E837A mutant CaR. These results suggest that the binding pockets of the 3 negative modulators in the hCaR 7TM may partially overlap.
Generation of Human Interferon Gamma and Tumor Necrosis Factor Alpha Chimeric TNT-3 Fusion Proteins (2002)

Studies have shown that cytokines can effectively treat solid tumors by a direct cytotoxic effect as well as by immunomodulation. Both human interferon gamma (IFNgamma) and tumor necrosis factor alpha (TNFalpha) have been used to treat a variety of colon carcinoma cell lines and tumors in patients. These cytokines, however, are dose limited by their toxicity and fast clearance rates when given intravenously. To improve their therapeutic value, we now report on the generation of two new fusion proteins consisting of human IFNgamma and TNFalpha genetically linked to the C-terminal portion of chTNT-3, a monoclonal antibody (MAb), which targets human solid tumors by binding to intracellular antigens exposed in degenerating cells associated with tumor necrosis. In vitro characterization studies demonstrate that both the IFNgamma and TNFalpha fusion proteins are able to maintain their binding affinity to antigen as well as their direct cytotoxic effect and immunomodulatory functions. When both fusion proteins are combined at optimal doses, they demonstrate a 30% direct cellular cytotoxicity of human colon carcinoma cells of which approximately 14% can be attributed to apoptosis. In vivo, these agents were studied for their pharmakocinetic clearance rates and their ability to target human colon carcinomas heterotransplanted in nude mice. The results of these studies show that, compared with chTNT-3 parental antibody, both fusion proteins have a substantially shorter whole body half-life, yet are able to target tumor in a similar manner. As each of these fusion proteins are cleared from the circulation and normal tissues, tumor-to-normal-tissues ratios rise demonstrating the retention of these reagents in tumor. The generation of long-acting and targeted human IFNgamma and TNFalpha antibody fusion proteins will enable investigators to study the role of these potent immunostimulatory cytokines in the treatment of human solid tumors.
Supplementary Tables 1 - 4 from Activation of the <i>NOTCH</i> Pathway in Head and Neck Cancer (2023)

&lt;p&gt;PDF file - 88K, Supplementary Table I. Baseline characteristics of the HNSCC patients for microarray analysis. Supplementary Table II. Short Tandem Repeat Profile of the 2 HNSCC Cell Lines. Supplementary Table III. NOTCH Signaling Pathway Genes assigned in KEGG pathway database and shown on expression microarrays. Supplementary Table IV. Summary of the mRNA levels of NOTCH signaling pathway genes in the cohort of 44 HNSCC tumors and 25 normal mucosas measured by Affymetrix expression array.&lt;/p&gt;
qConut: A mobile geospatial application for promoting sustainable and climate-smart Pacific Island agricultural landscapes (2020)

&amp;lt;p&amp;gt;Successful &amp;amp;#8216;smart&amp;amp;#8217; agricultural interventions provide mutually positive impacts to inhabitants&amp;amp;#8217; livelihoods, landscape sustainability, and the capacity of a system to respond effectively to climate variability. Geospatial technological tools have the potential for accurate and timely locational monitoring within multifunctional landscapes. Information derived from using such tools can substantially inform environmental management, policy, and climate-resilient practice. Our research is developing a mobile geospatial application for contemporary data collection and monitoring, allowing the dynamic capture of landscape information. Through community consultations, stakeholder engagement activities, and Information and Communications Technologies for Development (ICT4D) user requirements analysis, we have mapped government data flows and information needs of smallholder farmers in the Pacific Island nations of Fiji and Tonga. Subsequently, the barriers experienced by landscape users to access and understand relevant, reliable and usable environmental data and information were identified. We then designed an open-source mobile geospatial application to facilitate knowledge sharing between different landscape stakeholders. Our multi-user open source application &amp;amp;#8211; qConut &amp;amp;#8211; is being co-developed with the Ministry of Forests in Fiji and the Ministry of Agriculture, Food and Forests in Tonga, alongside collaborative participatory contributions from the wider farming communities. Here we present the methodological approach, application functionality, and prototype usability outcomes from field testing undertaken in the Ba Catchment, Fiji, and Tongatapu, Tonga. The qConut application has a current target user focus on agricultural extension officers who are trialling the application within cropping and forestry sectors. Results of trial usage highlight the importance of understanding the specific needs and capacities of all stakeholder groups in developing effective digitally-enabled climate information services. By utilising mobile geospatial technologies our research is helping to address shortcomings in location-targeted information delivery, environmental monitoring, and data sharing within Pacific Island agricultural communities. See www.livelihoodsandlandscapes.com for further information.&amp;lt;/p&amp;gt;
Product System Families at Rolls‐Royce: A Case Study in Enterprise Transformation (2016)

Abstract This case study describes the initial stages of Product System Families, a project to develop generic, reusable system design artefacts applicable to the complex systems with which Rolls‐Royce equips its aerospace products. Using the example of a gas turbine tip clearance control system, the system thinking behind Product System Families is outlined and the development of the generic artefacts themselves is described, together with the challenges of developing them within the fast‐moving, complex enterprise that is Rolls‐Royce's engineering function. The ultimate aim is to have much of the product design captured in a series of ‘house styles’ which represent the most advanced, optimized solution and can then be customized quickly and cost‐effectively to specific customer needs.
An analysis of queries intended to search information for children (2010)

\n Contains fulltext :\n 227306.pdf (Publisher’s version ) (Closed access)\n
The relationship between lymphocyte transformation and immune response. 3. Kinetics of production of antibody forming cells and transforming cells. (1970)

Rabbits immunized with a single dose of sheep erythrocytes were used to compare the kinetics of production of antibody forming cells (both rosette and plaque forming cells) and lymphocytes that transform in culture in the presence of the specific antigen. The latter activity is assumed to represent immunological memory. Low levels of the three cellular activities were detected in most unimmunized animals. The first response to be found in the immunized animals was an increase in number of PFC in the spleen, 3 days after injection, while rosette forming and transforming cells increased a day or two later. Active cells were detected in the blood of most animals about 1 day after they were found in the spleen. High levels of all activities were present 5–17 days after immunization. Spleen cells from rabbits tested 84–360 days after immunization showed remarkable levels of transformation activity, while the values of plaque and rosette-forming cells fell as low as in unimmunized (`background' levels). On the other hand, blood lymphocytes exhibited almost no transformation or antibody formation activity. Lymph node cells, tested in a few rabbits, exhibited intermediate degrees of transformation response.
Multiplexed Amino Acid Array Utilizing Bioluminescent Escherichia coli Auxotrophs (2010)

We describe a novel multiplex "amino acid array" for simultaneously quantifying different amino acids based on the rapid growth of amino acid auxotrophic E. coli. First, we constructed genetically engineered amino acid auxotrophs of E. coli containing a bioluminescence reporter gene, yielding concomitant luminescence as a response to cell growth, and then immobilized the reporter cells within individual agarose of respective wells in a 96-well plate serving as a mimic of a biochip. Using the amino acid array, we were able to determine quantitatively the concentrations of 16 amino acids in biological fluid by simply measuring bioluminescent signals from the immobilized cells within 4 h without pre- and post-treatment. The clinical utility of this method was verified by quantifying different amino acids in dried blood spot specimens from clinical samples for the diagnosis of metabolic diseases of newborn babies. This method serves as a convenient route to the rapid and simultaneous analysis of multiple amino acids from complex biological fluids and represents a new analytical paradigm that can replace conventional, yet laborious methods currently in use.
Structural Weaknesses in the Open Smart Grid Protocol (2015)

The Open Smart Grid Protocol (OSGP) is currently deployed in various countries in large-scale Smart Metering projects. The protocol was developed by the OSGP Alliance and published as a standard by the European Telecommunications Standards Institute (ETSI). We identify several security issues in the OSG Protocol, primarily the use of a weak digest function and the way the protocol utilizes the RC4 algorithm for encryption. A straight-forward oracle attack triggers the leakage of key material of the digest function. We outline how an attacker can make use of the simple protocol structure to send maliciously altered messages with valid authentication tags to the meters.
An Analysis of Likely Scalants in the Treatment of Produced Water From Nova Scotia (2014)

A significant barrier to further use of hydraulic fracturing to recover shale oil and/or gas is the treatment and/or disposal of hypersaline produced water. This work is an analysis of produced water from Nova Scotia, with the aim of understanding how scale impacts the choice of desalination system used in its treatment. Four water samples are presented, and for a representative case, the supersaturation of some likely scalants is estimated as a function of temperature, recovery ratio, and pH. This supersaturation map is then compared to conditions representative of common desalination systems, allowing the identification of limitations imposed by the water's composition. In contrast to many natural waters, it is found that sodium chloride is the most likely first solid to form at high recovery ratios, and that the top temperature of thermal desalination systems is unlikely to be scale-limited in the treatment of these waters.
Plasmonic waveguide coupling at terahertz frequencies (2012)

Two approaches for coupling terahertz radiation to surface plasmonic waveguides are proposed and simulated. The first approach utilizes a rectangular waveguide with a tapered plasmonic feed, which allows for the gradual confinement of terahertz waves into a plasmonic structure. The second method employs a ribbon dielectric waveguide, which edge couples terahertz radiation onto a surface plasmonic structure. Coupling designs are presented along with simulation results.
Scalable Synthesis of the Potent HIV Inhibitor BMS‐986001 by Non‐Enzymatic Dynamic Kinetic Asymmetric Transformation (DYKAT) (2015)

Described herein is the synthesis of BMS-986001 by employing two novel organocatalytic transformations: 1) a highly selective pyranose to furanose ring tautomerization to access an advanced intermediate, and 2) an unprecedented small-molecule-mediated dynamic kinetic resolution to access a variety of enantiopure pyranones, one of which served as a versatile building block for the multigram, stereoselective, and chromatography-free synthesis of BMS-986001. The synthesis required five chemical transformations and resulted in a 44% overall yield.
Evidence for Higgs boson decay to a pair of muons (2021)

A bstract Evidence for Higgs boson decay to a pair of muons is presented. This result combines searches in four exclusive categories targeting the production of the Higgs boson via gluon fusion, via vector boson fusion, in association with a vector boson, and in association with a top quark-antiquark pair. The analysis is performed using proton-proton collision data at $$ \sqrt{s} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msqrt><mml:mi>s</mml:mi></mml:msqrt></mml:math> = 13 TeV, corresponding to an integrated luminosity of 137 fb − 1 , recorded by the CMS experiment at the CERN LHC. An excess of events over the back- ground expectation is observed in data with a significance of 3.0 standard deviations, where the expectation for the standard model (SM) Higgs boson with mass of 125.38 GeV is 2.5. The combination of this result with that from data recorded at $$ \sqrt{s} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msqrt><mml:mi>s</mml:mi></mml:msqrt></mml:math> = 7 and 8 TeV, corresponding to integrated luminosities of 5.1 and 19.7 fb − 1 , respectively, increases both the expected and observed significances by 1%. The measured signal strength, relative to the SM prediction, is $$ {1.19}_{-0.39}^{+0.40}{\left(\mathrm{stat}\right)}_{-0.14}^{+0.15}\left(\mathrm{syst}\right) $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msubsup><mml:mn>1.19</mml:mn><mml:mrow><mml:mo>−</mml:mo><mml:mn>0.39</mml:mn></mml:mrow><mml:mrow><mml:mo>+</mml:mo><mml:mn>0.40</mml:mn></mml:mrow></mml:msubsup><mml:msubsup><mml:mfenced><mml:mtext>stat</mml:mtext></mml:mfenced><mml:mrow><mml:mo>−</mml:mo><mml:mn>0.14</mml:mn></mml:mrow><mml:mrow><mml:mo>+</mml:mo><mml:mn>0.15</mml:mn></mml:mrow></mml:msubsup><mml:mfenced><mml:mtext>syst</mml:mtext></mml:mfenced></mml:math> . This result constitutes the first evidence for the decay of the Higgs boson to second generation fermions and is the most precise measurement of the Higgs boson coupling to muons reported to date.
Update onActinobacillus pleuropneumoniae-knowledge, gaps and challenges (2017)

Porcine pleuropneumonia, caused by the bacterial porcine respiratory tract pathogen Actinobacillus pleuropneumoniae, leads to high economic losses in affected swine herds in most countries of the world. Pigs affected by peracute and acute disease suffer from severe respiratory distress with high lethality. The agent was first described in 1957 and, since then, knowledge about the pathogen itself, and its interactions with the host, has increased continuously. This is, in part, due to the fact that experimental infections can be studied in the natural host. However, the fact that most commercial pigs are colonized by this pathogen has hampered the applicability of knowledge gained under experimental conditions. In addition, several factors are involved in development of disease, and these have often been studied individually. In a DISCONTOOLS initiative, members from science, industry and clinics exchanged their expertise and empirical observations and identified the major gaps in knowledge. This review sums up published results and expert opinions, within the fields of pathogenesis, epidemiology, transmission, immune response to infection, as well as the main means of prevention, detection and control. The gaps that still remain to be filled are highlighted, and present as well as future challenges in the control of this disease are addressed.
PDGFR TK assay for screening inhibitory compound-libararies (2004)

Introduction: Changes in the expression of platelet-derived growth factor receptor (PDGFR) have been described in gastrointestinal tumors, and correlated with more aggressive behaviour. This finding suggests that blockade of PDGF-dependent growth pathways may be an effective strategy to inhibit growth of these tumors.
AVXS-101 Phase 1 Gene Therapy Clinical Trial in SMA Type 1: Correlation between CHOP-INTEND and Motor Milestone achievements (S13.002) (2017)

Spinal muscular atrophy is a devastating, monogenic neurodegenerative disease that in its most severe form, SMA Type 1 (SMA1), afflicted children never sit unassisted, this inability being the hallmark of SMA1. Natural history studies of SMA1 children reported that almost none achieved a CHOP-INTEND score of >40. Here we report the apparent correlation between achievement of CHOP-INTEND scores ≥50 and sitting unassisted.
Increased interleukin-6 and macrophage chemoattractant protein-1 are associated with respiratory failure in COVID-19 (2020)

In SARS-CoV-2 infection there is an urgent need to identify patients that will progress to severe COVID-19 and may benefit from targeted treatment. In this study we analyzed plasma cytokines in COVID-19 patients and investigated their association with respiratory failure (RF) and treatment in Intensive Care Unit (ICU). Hospitalized patients (n = 34) with confirmed COVID-19 were recruited into a prospective cohort study. Clinical data and blood samples were collected at inclusion and after 2-5 and 7-10 days. RF was defined as PaO2/FiO2 ratio (P/F) < 40 kPa. Plasma cytokines were analyzed by a Human Cytokine 27-plex assay. COVID-19 patients with RF and/or treated in ICU showed overall increased systemic cytokine levels. Plasma IL-6, IL-8, G-CSF, MCP-1, MIP-1α levels were negatively correlated with P/F, whereas combinations of IL-6, IP-10, IL-1ra and MCP-1 showed the best association with RF in ROC analysis (AUC 0.79-0.80, p < 0.05). During hospitalization the decline was most significant for IP-10 (p < 0.001). Elevated levels of pro-inflammatory cytokines were present in patients with severe COVID-19. IL-6 and MCP-1 were inversely correlated with P/F with the largest AUC in ROC analyses and should be further explored as biomarkers to identify patients at risk for severe RF and as targets for improved treatment strategies.
A Mixed-Initiative Interface for Animating Static Pictures (2018)

We present an interactive tool to animate the visual elements of a static picture, based on simple sketch-based markup. While animated images enhance websites, infographics, logos, e-books, and social media, creating such animations from still pictures is difficult for novices and tedious for experts. Creating automatic tools is challenging due to ambiguities in object segmentation, relative depth ordering, and non-existent temporal information. With a few user drawn scribbles as input, our mixed initiative creative interface extracts repetitive texture elements in an image, and supports animating them. Our system also facilitates the creation of multiple layers to enhance depth cues in the animation. Finally, after analyzing the artwork during segmentation, several animation processes automatically generate kinetic textures that are spatio-temporally coherent with the source image. Our results, as well as feedback from our user evaluation, suggest that our system effectively allows illustrators and animators to add life to still images in a broad range of visual styles.
Fabrication of uniform porous CNTs/activated carbon composite spheres by oil-drop method in stratified oils and their adsorption of VB12 (2015)

Uniform porous CNTs/activated carbon composite spheres were prepared by oil-drop method followed by gradual suspension curing in stratified oils.
Multicomponent polymer coating to block photocatalytic activity of TiO2 nanoparticles (2007)

Chemical grafting of anti-oxidant molecules with an additional hydrophobic polymer coating directly onto TiO(2) particle surfaces, using sonochemistry, is found to eliminate photocatalytic degradation enabling highly effective screening against UV radiation.