gebhart/patrepeval huggingface dataset:
Ultrasound characterization of slow precipitating implants for vascular occlusion (2017)

A frequently utilized clinical treatment for liver cancer is the administration of drug eluting microspheres that embolize tumor vasculature depriving it of oxygen and nutrients. However, these beads are fairly large, leading to embolization far away from the tumor and reducing drug penetration. As an alternative, we have developed a slow precipitating in situ forming implant (ISFI) capable of deeper penetration and embolization, which we hypothesize will result in better treatment efficacy. In this study, ultrasound was utilized to determine precipitation kinetics of ISFI formulations formulated with varying solvent polarity and polymer molecular weight. Increasing polymer molecular weight from 15 kDa to 53 kDa led to a significant increase in precipitation rate after 5 minutes. A decrease in solvent polarity also led to a significantly higher precipitation rate, which was unexpected, but may be due to attenuation in polymer-rich and polymer-lean microdomains created with a low polar solvent. Tissue mimicking single channel phantoms were then used to determine occlusion distances. An increase in polymer molecular weight to 53kDa was the best formulation meeting both the aforementioned criteria. This study demonstrates, for the first time, ultrasound can be used non-invasively to monitor precipitation kinetics ISFIs to better predict vascular embolization.
Influence of modularity and economy-of-scale effects on design of mesh-restorable DWDM networks (2000)

This work is motivated by interest in restorable mesh architectures for WDM optical networking DWDM technology is expected to create an extremely modular capacity-planning situation and to produce potentially strong nonlinear economy-of-scale effects in capacity. How will this influence the design of cost-optimized mesh-restorable networks? Will it be essential to do true modular design optimization, or will the traditional rounding-up procedure still be adequate? Can a true modular design method exploit these effects for capital cost savings in the network design? What influence would strong modularity and economy-of-scale have on the evolution of the fiber facilities graph topology for these networks? We address these questions with three mathematical programming formulations that allow a comparative study of these issues in terms of the cost and architectural differences between networks designed with different treatments of the modularity issue. Results show that there are worthwhile savings to be had by bringing modularity aspects directly into the basic design formulation, rather than postmodularizing a continuous integer result, as done in most prior practice. The most significant research finding may be the demonstration of topology reduction (or paring down of the facilities graph) arising spontaneously in optimized designs under the combined effects of high modularity and economy-of-scale. This is the first quantitative indication and explanation of why less highly connected graph topologies may be preferred (at least from an economic standpoint) in future WDM networks, even though the spare capacity efficiency for mesh-based restoration is improved by higher connectivity.
A Home-Proxy Based Wireless Internet Framework in Supporting Mobility and Roaming of Real-Time Services (2001)

Due to the lack of support in mobility and quality of service, today&amp;apos;s IP-based networks have some inherent limitations for delivering multimedia services in a mobile environment. In the past few years, these issues have been addressed in the research community and the resulting techniques are being standardised. However, these developments have been done in isolation and become incompatible to each other. In addition to these technical issues, the future infrastructure for charging and accounting mobile multimedia services is expected to be increasingly complicated. In this paper we present a home-proxy based framework which can facilitate the integration of mobility support and QoS management. Furthermore, it enables centralised accounting, which simplifies the cost recovery processes of roaming services. To prove the viability of our design, we have built and tested this framework on a DiffServ wide-area backbone using an MP3 streaming application.
Digital Archiving of Tapestries of Kyoto Gion Festival Using a High-Definition and Multispectral Image Capturing System (2013)

We report the archiving project of Kyoto Gion Festival using high-resolution multiband imaging camera. We have been developing a two-shot six-band image capturing system for recording the color and physical properties of early modern tapestries. In an experiment, an image of tapestry whose image size was 2700 M-pixel was synthesized. The resolution of the images was 0.02 mm/pixel. Accurate color under an arbitrary illumination and spectral reflectance can be reproduced from the 6-band image using the Wiener estimation.
Combination of Radiotherapy and Adenovirus-Mediated p53 Gene Therapy for MDM2-Overexpressing Hepatocellular Carcinoma (2012)

The p53 gene plays a determinant role in radiation-induced cell death and its protein product is negatively regulated by MDM2. We investigated whether adenovirus-mediated modified p53 gene transfer, which blocks p53-MDM2 binding, is effective for radiation-induced cell death in hepatocellular carcinoma (HCC) at different MDM2 cellular levels. Human hepatocellular carcinoma cell lines expressing MDM2 at low levels (Huh7) and high levels (SK-Hep1) were used. Ad-p53 and Ad-p53vp are replication-deficient adenoviral vectors containing human wild-type or modified p53, respectively. The anti-tumor effect was highest for Ad-p53 + radiotherapy (RT) in the low-level MDM2 cells, whereas this effect was highest for Ad-p53vp + RT in the MDM2-overexpressing cells. In Huh-7 cells, Ad-p53 + RT decreased cell viability (32%) in vitro and inhibited tumor growth (enhancement factor, 1.86) in vivo. Additionally, p21 expression and apoptosis were increased. In contrast, in SK-Hep1 cells, Ad-p53vp + RT showed decreased cell viability (51%) in vitro and inhibition of tumor growth (enhancement factor, 3.07) in vivo. Caspase-3 expression and apoptosis were also increased. Adenovirus-expressing modified p53, which blocks p53-MDM2 binding, was effective in killing tumor cells overexpressing MDM2. Furthermore, the combination strategy for disruption of the p53-MDM2 interaction with RT demonstrated enhanced anti-tumor effects both in vitro and in vivo.
Novel role of mortalin in attenuating HIV-1 Tat-mediated astrogliosis (2020)

Overall, our data demonstrated the protective role of mortalin in combating HIV-1 Tat-mediated damage. We also showed that mortalin could degrade Tat through direct binding with HIV-1 Tat. Overexpression of mortalin in the presence of Tat could significantly reduce cytotoxic effects of Tat in astrocytes. Indirect neuronal death was also found to be rescued. Our in vitro findings were validated as we found attenuated expression of mortalin in the autopsy sections of HIV-1 patients.
SUSPECT ACTIVITY RECOGNITION USING IMAGE PROCESSING AND MACHINE LEARNING ALGORITHMS (2020)

There are a set of ATM attacks like physical attack, ATM Fraud, Computer and network attack.Most of the methods as in using the classifier to classify occurrences and doesn't use the video input. These optimization algorithms involve learning time and close attention to the training collection of data. The proposed solution uses a lower resolution USB device, and a prototype webcam. The web camera broadcasts live video, and the images are Recorded for processing the image. Open CV is used and our device's open source image processing algorithms. Suspicious activity throughout the ATM and is identified for the proposed algorithm using the methods described out below. If any suspicious event is occurred then the alarm is heard and the message is sent to the nearest crime stations.
Packaging-related properties of protein- and chitosan-coated paper (2005)

The mechanical and gas-barrier properties of paper and paperboard coated with chitosan–acetic acid salt (chitosan), whey protein isolate, whey protein concentrate and wheat gluten protein were studied. Paper sheets were solution-coated using a hand applicator. In addition, bi-layer composites of wheat gluten and paper or paperboard were produced by compression moulding, and the chitosan solution was also applied on paperboard using curtain coating. Young's modulus, fracture stress, fracture strain, tearing strength, air permeance and oxygen permeability were assessed. The mechanical and air permeance measurements of solution-coated paper showed that chitosan was the most effective coating on a coat weight basis. This was due to its high viscosity, which limited the degree of penetration into the paper. The proteins, however, also enhanced the strength and toughness of the paper. Compression-moulded wheat gluten/paper or paperboard, as well as curtain-coated chitosan paperboard laminates, showed oxygen barrier properties comparable to those of paper and paperboard coated with commercial barrier materials. None of the composites could be delaminated without fibre rupture, indicating good adhesion between the coatings and the substrates. Copyright © 2005 John Wiley & Sons, Ltd.
Fabrication of Al2O3-TiN Micro-composite Derived from TiO2 Precursor (2006)

Al2O3-TiN micro-composite powder was prepared by reduction and nitridation of mixed Al2O3-TiO2 powder. By adding Ti-isopropoxide as TiO2 source, TiO2-coated Al2O3 grain was obtained. A suitable condition for the reduction and nitridation was determined at 950-1450°C in a flowing mixed N2-H2 gas, with suppressed grain growth and sufficient nitridation. A partial coating was observed in Al2O3-TiN composite powder as well as in the Hot-pressed sintered body, which enhances the electric conductivity. Therefore, this method is promising for preparing materials for electric discharge machining.
Molecular Beam Epitaxial Growth of GaN Nanocolumns and Related Nanocolumn Emitters (2017)

This chapter reviews studies on Gallium nitride (GaN)-based nanocolumns performed at Sophia University are systematically. It addresses the first self-organization of nanocolumns, visible-light-emitting InGaN-based nanocolumns, and the nanocrystal effects of such nanocolumns, controlled growth of regularly arranged nanocolumns by molecular beam epitaxy (MBE), and application of GaN nanocolumns to nanocolumn light emitters. GaN nanocolumns, which are one-dimensional nanocrystals with diameters of less than several hundred nanometers, have been self-organized by radio-frequency-plasma-assisted MBE and subsequently extensively studied. Nanocolumn light-emitting diodes consist of a huge number of GaN-based nanocolumns, spontaneously nucleated during their self-organization. A technique for selective-area growth of nanocolumns on GaN templates has been developed to achieve precise control in the size and position of nanocolumns, resulting in uniform arrays of GaN nanocolumns. GaN nanocolumn templates with heights of 150–200 nm were employed to enhance the nucleation of Aluminium GaN nanocrystals on them, which was essential to forming the nanocolumn structure of the Aluminium GaN.
Peptides from Conus Venoms which Affect Ca ++ Entry into Neurons (1990)

The venoms of fish-hunting Conus contain paralytic conotoxins and an unprecedented variety of other biologically-active peptides. Particularly noteworthy are peptides which inhibit calcium entry into neurons, the conantokins and w-conotoxins which target NMDA receptors and voltage-sensitive Ca channels respectively.The conantokins contain at least four residues of γ-carboxyglutamate (Gla), a post-translationally modified amino acid. Conantokins are folded into an α-helical conformation and bind acidic membranes in a calcium-dependent manner. Upon envenomation, conantokins may concentrate on appropriate membranes and target to peripheral fish NMDA receptors located on such membranes.The w-conotoxins are disulfide bonded peptides; a comparison of several w-conotoxin sequences reveals considerable sequence variability. Recent studies with w-conotoxins have also revealed a developmental specificity in mice. The results suggest that elements controlling breathing in neonatal mammals, but not in adults, are w-conotoxin sensitive.
Reevaluating cell wraparound techniques for 3D channel model based system-level simulations (2015)

Current wireless system-level simulation frameworks utilize cell wraparound in order to reduce boundary effects and provide an accurate evaluation of system performance. The current wraparound technique is purely distance based, where UEs always pick the closest cells, ignoring the radio propagation characteristics of the channel. While this wraparound methodology works well for a 2D channel model, it fails to account for the enhancements and spatial characteristics of the 3D channel model. In this paper we investigate the use of a radio distance based wraparound scheme for 3D channel models. This new wraparound methodology uses received downlink signal power to perform wraparound cell selection, allowing it to account for the radio propagation characteristics of the 3D channel model. We compare the performance of these two wraparound techniques with respect to coupling gain and other key metrics when considering a 3D channel model. Our results demonstrate the differences between the two schemes and highlight the improved accuracy offered by the radio distance based wraparound scheme.
Quantitative study of two indirubin derivatives: 6-Bromoindirubin-3′-oxime (6BIO) and 6-Bromoindirubin-3′-[O-(2-piperazine-1-ylethyl) oxime] (6BIO-pip) in mice plasma by LC-MS/MS. Application in a pharmacokinetic study (2014)

Indirubins represent a group of natural and synthetic products with bio-activities against numerous human cancer cell lines by inhibiting protein kinases. The natural sources of indirubins are plants of Isatis sp., Indigofera sp., and Polygonum sp., recombinant bacteria, mammalian urine and some marine mollusks [1]. Specifically, the halogenated derivative 6-bromo indirubin-3′-oxime (6BIO) possesses an increased selectivity against GSK-3 and 6-Bromoindirubin-3′-[O-(2-piperazine-1-ylethyl) oxime] (6BIO-pip) demonstrates dual JAK/Src inhibitory activity and suppresses tumor cell growth both in vitro and in vivo [2,3]. However, to our knowledge, no analytical method to determine 6BIO and 6BIO-pip in biological fluids has been developed till now. Therefore, rapid, sensitive and high throughput UHPLC-MS/MS methods were developed and validated to evaluate the concentrations of 6BIO and 6BIO-pip in mice plasma. Plasma samples were pre-treated by protein precipation using cold mixture of methanol: acetonitrile (9: 1, v/v) and separations were carried out on a Hypersil Gold C18 column (50 × 2.1 mm i.d.; 1.9 µm p.s.) using 0.1% acetic acid and methanol as mobile phase at a flow rate of 500 mL/min in a gradient mode. For quantitation, a hybrid LTQ-Orbitrap MS equipped with an electro-spray ionization source was used applying a selected reaction monitoring (SRM) option. The monitored transitions were m/z 354→324 in negative mode for 6BIO and m/z 468→356 in positive mode for 6BIO-pip. Following the guidelines of EMA, the assay methods were fully validated in terms of selectivity, linearity, recovery, matrix effect, accuracy, precision and stability. The validated methods were successfully applied to the pharmacokinetic studies of 6BIO and 6BIO-pip following their oral administration to mice at the dose of 50 mg/kg. The results indicated that the higher solubility of 6BIO-pip provided it a higher plasma bioavailability and stability as compared to 6BIO.
Lipid composition of aorta of Watanabe heritable hyperlipemic and comparably hypercholesterolemic fat-fed rabbits. Plasma lipid composition determines aortic lipid composition of hypercholesterolemic rabbits. (1988)

Aortic and plasma lipid compositions were compared during a 12-month period in Watanabe heritable hyperlipemic (WHHL), comparably hypercholesterolemic fat-fed, and age-matched control normolipidemic rabbits to determine whether exposure to equivalent degrees of endogenous or exogenous hypercholesterolemia led to differences in the composition and concentration of lipids deposited in the artery wall. Although there were marked differences in the distribution of cholesterol among the lipoproteins in the WHHL versus the fat-fed rabbits, the contents of both free and esterified cholesterol were elevated to an equivalent degree in the aorta and plasma. In contrast, the triglyceride content of both the plasma and aorta were elevated only in the WHHL rabbits. However, aortic total phospholipids were increased in both the WHHL and fat-fed animals as compared to control rabbits. In the control rabbits, there was an age-dependent enrichment in aortic relative to plasma cholesteryl-oleate consistent with low density lipoprotein (LDL) receptor-directed intracellular cholesteryl ester processing. In contrast, enrichment in cholesteryl-oleate in aortae relative to plasma was not detected in either WHHL or fat-fed groups, suggesting that the plasma cholesteryl ester composition was the primary determinant of the aortic cholesterol composition. Thus, during chronic hypercholesterolemia, deposition of lipids in the artery wall appears to be determined by plasma lipoprotein levels and composition if the LDL receptor is either absent on a genetic basis or suppressed due to a high-fat, high-cholesterol diet.
The Transition Metal-Catalyzed Intermolecular [5+2] Cycloaddition:  The Homologous Diels−Alder Reaction (1998)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTThe Transition Metal-Catalyzed Intermolecular [5+2] Cycloaddition: The Homologous Diels−Alder ReactionPaul A. Wender, Heiko Rieck, and Masahiro FujiView Author Information Department of Chemistry, Stanford University Stanford, California 94305 Cite this: J. Am. Chem. Soc. 1998, 120, 42, 10976–10977Publication Date (Web):October 13, 1998Publication History Received24 June 1998Published online13 October 1998Published inissue 1 October 1998https://doi.org/10.1021/ja982196xCopyright © 1998 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views2692Altmetric-Citations133LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (83 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Addition reactions,Catalysts,Cyclization,Hydrocarbons,Ketones Get e-Alerts
Influence of surface microstructure on the electric and spectroscopic characteristics of dielectric surface flashover (1994)

Spectroscopic investigations were performed on high purity polycrystalline alumina in vacuum to understand the effect of surface microstructure as altered by mechanical surface treatment, on the optical as well as the electrical characteristics of dielectric surface flashover. HV pulses were applied to unpolished samples as well as to samples subjected to mechanical polishing by using SiC (268 to 16 /spl mu/m) and diamond abrasives (15 to 0.25 /spl mu/m). The samples finished using diamond paste exhibited lower conditioned voltages and holdoff strength than those prepared with SiC abrasive finish. The spectrum of diamond-finished samples showed early development of molecular bands associated with the dielectric material. This behavior could be due to a larger density of defects developed on the surface during final polishing with diamond paste. There seems to be a correlation between the electrical performance of a sample, the polishing medium used for its surface finish, and the development of some of the spectral lines from flashover. The experimentally-observed phenomena in the studies point to different phases of surface conditioning, in which the dominating factors for the origin of surface flashover seem to depend on the surface state of the insulator.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Cooperating Layered Architecture for SDN (2015)

Software Defined Networking proposes the separation of the control
plane from the data plane in the network nodes and its logical
centralization on a control entity. Most of the network intelligence
is moved to this functional entity. Typically, such entity is seen as
a compendium of interacting control functions in a vertical, tight
integrated fashion. The relocation of the control functions from a
number of distributed network nodes to a logical central entity
conceptually places together a number of control capabilities with
different purposes. As a consequence, the existing solutions do not
provide a clear separation between transport control and services that
relies upon transport capabilities. This document describes a proposal
named Cooperating Layered Architecture for SDN. The idea behind that
is to differentiate the control functions associated to transport from
those related to services, in such a way that they can be provided and
maintained independently, and can follow their own evolution path.
Microcystic Serous Cystadenoma of the Pancreas With Subtotal Cystic Degeneration (2012)

Most pancreatic serous cystadenomas display characteristic morphology, including a glycogen-rich epithelial lining and prominent subepithelial capillaries; however, extensive degenerative macrocystic change can obscure these classic features. This phenomenon is to be distinguished from macrocystic serous cystadenoma, in which thin-walled macrocystic spaces are epithelium lined. Thus, serous cystadenoma should be included in the differential diagnosis of pancreatic masses with extensive degenerative cystic change.
Why a New Anesthesia Journal? (2023)

Anesthesia Research (ISSN 2813-5806) is the new open-access journal published by MDPI [...]
Fungal Polysaccharides: Biological Activity Beyond the Usual Structural Properties (2011)

Studies on structure and function of polysaccharides in biological systems classically involve sequence and compositional analyses, anomeric configuration, type of glycosidic linkage, and presence of substituents. Recent studies, however, indicates that other structural parameters, so far little explored, can directly influence the biological activity of microbial polysaccharides. Among these parameters, we highlight the molecular dimensions of Cryptococcus neoformans polysaccharides, which appear to be inversely correlated with their immunobiological activity. These recent observations raise new concepts about the structure and function of polysaccharides, which stimulates the design of new experimental approaches and suggests previously unknown applications.