gebhart/patrepeval huggingface dataset:
Differentiation of human CD34+CD38- cord blood stem cells into B cell progenitors in vitro. (1997)

Umbilical cord blood CD34+CD38- cells are a rare, quiescent, primitive progenitor subpopulation lacking expression of lymphoid and myeloid lineage specific antigens. Although myeloid, erythroid, and megakaryocytic differentiation from these cells has been described, B lineage differentiation has not been demonstrated previously. We report here that highly enriched human B cell progenitors can be consistently generated from CD34+CD38- cord blood cells using long-term culture on the murine stromal line, S17, in the absence of added cytokines. After 6-8 weeks, cell numbers increased up to 160-fold, and cultures contained > 80-90% CD10+CD19+ B progenitors. Consistent with previous reports describing delayed myeloid cell differentiation from CD34+CD38- cells, production of B cell progenitors from CD34+CD38- cord blood cells was delayed 2-4 weeks relative to cultures initiated with either CD34+CD38bright or CD34+CD38dim progenitors. Addition of Flt3 ligand to long-term cultures resulted in a 2-3-fold greater increase in the number of CD19+ cells generated after 4-8 weeks. The selective outgrowth of B cell progenitors using this culture model will be useful for a range of in vitro studies using primitive hematopoietic progenitors.
Potential asbestos exposure among patients with primary lung cancer in Japan (2018)

In a Japanese population representing more workers than general Japanese, 12.8% of patients with primary lung cancer may have experienced asbestos exposure at some time in the past. Special medical attention should be paid to individuals with a history of employment in construction-related occupations, as workers in this sector showed the highest prevalence of pleural plaques.
Predicting the pathogenesis of influenza from genomic response: a step toward early diagnosis (2011)

Infection with influenza virus does not always lead to symptomatic illness, but it is not currently possible to predict who will be severely affected and who will have mild or no symptoms. Gene expression profiling of biofluids might unlock the complex dynamics of response to acute respiratory virus infections such as influenza. A recent article by Alfred Hero and colleagues used transcriptional microarray analyses to follow the response to symptomatic and asymptomatic influenza infection over time, and revealed a role for type I IFN (IFNβ and IFNα) signaling and the NLRP3 inflammasome in determining the outcome in human infections.
A texture-based method for identificaiton of retinal vasculature (2011)

Noting the advantages of texture-based features over the structural descriptors of vascular trees, we investigated texture-based features from gray level cooccurrence matrix (GLCM) and various wavelet packet energies to classify retinal vasculature for biometric identification. Wavelet packet energy features were generated by Daubechies, Coiflets and Reverse Biorthogonal wavelets. Two different entropy methods, Shannon and logarithm of energy, were used to prune wavelet packet decomposition trees. Next, wrapper methods were used for classification-guided feature selection. Features were ranked based on area under the receiver operating curves, Bhattacharya, and t-test metrics. Using the ranked lists, wrapper methods were used in conjunction with Naïve Bayesian, k-nearest neighbor (k-NN), and Support Vector Machine (SVM) classifiers. Best results were achieved by using features from Reverse Biorthogonal 2.4 wavelet packet decomposition in conjunction with a nearest neighbor classifier, yielding a 3-fold cross validation accuracy of 99.42% with a sensitivity and specificity of 98.33% and 99.47% respectively.
The Val279Phe Variant of the Lipoprotein-Associated Phospholipase A2 Gene Is Associated with Catalytic Activities and Cardiovascular Disease in Korean Men (2006)

The association of the F279 loss of function variant with the reduced risk of CVD supports the concept that Lp-PLA(2) plays a proatherogenic and causative role in CVD.
Integrated and Spectrally Selective Thermal Emitters Enabled by Layered Metamaterials (2020)

Nanophotonic engineering of light-matter interaction at subwavelength scale allows thermal radiation that is fundamentally different from that of traditional thermal emitters and provides exciting opportunities for various thermal-photonic applications. We propose a new kind of integrated and electrically controlled thermal emitter that exploits layered metamaterials with lithography-free and dielectric/metallic nanolayers. We demonstrate both theoretically and experimentally that the proposed concept can create a strong photonic bandgap in the visible regime and allow small impedance mismatch at the infrared wavelengths, which gives rise to optical features of significantly enhanced emissivity at the broad infrared wavelengths of 1.4-14 um as well as effectively suppressed emissivity in the visible region. The electrically driven metamaterial devices are optically and thermally stable at temperature up to ~800 K with electro-optical conversion efficiency reaching ~30%. We believe that the proposed high efficiency thermal emitters will pave the way towards integrated infrared light source platforms for various thermal-photonic applications and particularly provide a novel alternative for cost-effective, compact, low glare, and energy-efficient infrared heating.
Semi-Analytical Model for the Performance Estimation of 100Gb/s PDM-QPSK Optical Transmission Systems without Inline Dispersion Compensation and Mixed Fiber Types (2013)

We propose a simple semi-analytical model to predict the performance of transmission systems without in-line dispersion compensation and mixed fiber types. Comparing with numerical simulations we show that our model predicts the Q2 factor with an accuracy of 0.2 dB.
Bithiopheneimide–Dithienosilole/Dithienogermole Copolymers for Efficient Solar Cells: Information from Structure–Property–Device Performance Correlations and Comparison to Thieno[3,4-c]pyrrole-4,6-dione Analogues (2012)

Rational creation of polymeric semiconductors from novel building blocks is critical to polymer solar cell (PSC) development. We report a new series of bithiopheneimide-based donor-acceptor copolymers for bulk-heterojunction (BHJ) PSCs. The bithiopheneimide electron-deficiency compresses polymer bandgaps and lowers the HOMOs--essential to maximize power conversion efficiency (PCE). While the dithiophene bridge progression R(2)Si→R(2)Ge minimally impacts bandgaps, it substantially alters the HOMO energies. Furthermore, imide N-substituent variation has negligible impact on polymer opto-electrical properties, but greatly affects solubility and microstructure. Grazing incidence wide-angle X-ray scattering (GIWAXS) indicates that branched N-alkyl substituents increased polymer π-π spacings vs linear N-alkyl substituents, and the dithienosilole-based PBTISi series exhibits more ordered packing than the dithienogermole-based PBTIGe analogues. Further insights into structure-property-device performance correlations are provided by a thieno[3,4-c]pyrrole-4,6-dione (TPD)-dithienosilole copolymer PTPDSi. DFT computation and optical spectroscopy show that the TPD-based polymers achieve greater subunit-subunit coplanarity via intramolecular (thienyl)S···O(carbonyl) interactions, and GIWAXS indicates that PBTISi-C8 has lower lamellar ordering, but closer π-π spacing than does the TPD-based analogue. Inverted BHJ solar cells using bithiopheneimide-based polymer as donor and PC(71)BM as acceptor exhibit promising device performance with PCEs up to 6.41% and V(oc) > 0.80 V. In analogous cells, the TPD analogue exhibits 0.08 V higher V(oc) with an enhanced PCE of 6.83%, mainly attributable to the lower-lying HOMO induced by the higher imide group density. These results demonstrate the potential of BTI-based polymers for high-performance solar cells, and provide generalizable insights into structure-property relationships in TPD, BTI, and related polymer semiconductors.
Abstract 219: Acyloxy Nitroso Compounds Inhibit LIF Signaling in Endothelial Cells and Cardiac Myocytes: Evidence That STAT3 Signaling is Redox-Sensitive (2012)

Nitroxyl donors have positive inotropic and lusitropic effects that may have therapeutic potential for treating heart failure, but their effects on other signaling pathways are not well studied. Previously we showed that leukemia inhibitory factor (LIF)-induced signaling is inhibited by oxidative stress, which targets JAK1 activation. In addition, we recently reported evidence for a cysteine-based redox switch in the JH1 catalytic domain of JAK 1 and 2. Since nitroxyl is thiophylic, we postulated that nitroxyl donors would inhibit LIF-induced JAK-STAT3 activation. Pretreatment of human microvascular endothelial cells (HMEC-1) or neonatal rat ventricular myocytes with the nitroxyl donors Angeli’s salt and the recently-described nitrosocyclohexyl acetate (NCA) inhibited LIF-induced STAT3 activation as indexed by Y705 phosphorylation. Pretreatment of HMEC-1 with NCA also blocked LIF-induced expression of the inflammation-related genes, ICAM-1 and CEBPD. The related acyloxy nitroso compound 1-nitrosocyclohexyl pivalate (NCP), which is not a nitroxyl donor, was equally effective in inhibiting STAT3 activation, suggesting that these compounds were acting as electrophiles on a thiolate residue. NCA had no effect on the catalytic activity of JAK1 and modestly affected JAK1-induced tyrosine phosphorylation of the LIF receptor. Thus, the JH1 redox switch is not a direct target of the acyloxy nitroso compound. However, pretreatment of recombinant human STAT3 with NCA or NCP reduced the labeling of free sulfhydryl residues with fluorescein-5-maleimide. In addition, we document by dimedone labeling that oxidation of STAT3 is associated with formation of sulfenic acid residues, a hallmark of redox-sensitive proteins. Altogether our evidence indicates that STAT3 has redox-sensitive cysteines that regulate its activation and are targeted by nitroxyl donors and related acyloxy nitroso compounds. These findings raise the possibility of new therapeutic strategies to target STAT3 signaling.
Modélisation d'antennes en VHDL-AMS pour systèmes RFID intégrés (2003)

International audience
Abstract 1775: Characterization of new highly selective and potent PARP-1 inhibitors (2012)

Abstract Poly (ADP-ribose) polymerase 1 (PARP-1) is a key nuclear enzyme that is activated by DNA-strand breaks; activation of PARP-1 protects DNA breaks and chromatin structure and recruits DNA repair and checkpoint proteins to the sites of damage, by modification with poly(ADP-ribose) (PAR) polymers. PARP-2, another nuclear member of the PARP family with largely unknown functions, shares homology with PARP-1 and is also activated by DNA breaks. Embryonic knock out of either PARP-1 or PARP-2 is well tolerated; however, double knockout is embryonic lethal suggesting that inhibiting both PARPs could enhance toxicity. PARP inhibitors in clinical development generally inhibit more than one PARP isoforms. These compounds are synthetic lethal with defects in homologous recombination (HR), and are currently being tested in combination as well as in monotherapy for hereditable cancers deficient in the BRCA1 or BRCA2 genes. Here we describe the in vitro and in vivo properties of a novel class of potent and selective PARP-1 small molecule inhibitors. Starting from a series of derivatives that were found to be active against PARP-1 and PARP-2, an expansion and optimization program was undertaken. This led to the identification of inhibitors with single digit nM affinity for PARP-1 and negligible crossreactivity against PARP-2. Members of this sub-series display single agent cytotoxicity with IC50s below 1 μM in cell lines harboring BRCA mutations, or in cells stably transfected with BRCA-1 short harpin RNA, and more than 100 times selectivity against BRCA wild-type tumor cell lines. Furthermore, these compounds are highly active in other repair deficient backgrounds such as ATM and Mre11 mutated acute leukemias and lymphomas and they compared favorably with reference PARP inhibitors which are in clinical development. Expected mechanism of action was confirmed by observed modulation of PAR induction, in vitro and in vivo. These compounds show high oral bioavailability, good ADME properties and high tolerability. Selection of the candidate most suitable for further development is underway. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1775. doi:1538-7445.AM2012-1775
Effect of Ceria on Hydrogen Production by Auto-Thermal Reforming of Propane Over Supported Nickel Catalysts (2013)

Autothermal reforming of propane was studied with respect to the addition of ceria to the supported Ni catalysts. Ni/Al2O3 catalysts showed a higher activity than Ni/MgAl catalysts. It was related to the ease of the catalyst reduction. Ni/Ce/MgAl and Ni/Ce/Al2O3 catalysts showed higher propane conversions and higher hydrogen yields. These were related to the particle size and the reducibilities of the catalysts. XRD analysis showed that the added CeO2 decreased the particle sizes of the supported Ni, but increased the amount of NiO on the catalyst surface, thus it improved the resistance to coking.
Heterogeneity of cancer‐associated fibroblasts: Opportunities for precision medicine (2020)

Despite marked development in cancer therapies during recent decades, the prognosis for advanced cancer remains poor. The conventional tumor-cell-centric view of cancer can only explain part of cancer progression, and thus a thorough understanding of the tumor microenvironment (TME) is crucial. Among cells within the TME, cancer-associated fibroblasts (CAFs) are attracting attention as a target for cancer therapy. However, CAFs present a heterogeneous population of cells and more detailed classification of CAFs and investigation of functions of each subset is needed to develop novel CAF-targeted therapies. In this context, application of newly developed approaches to single-cell analysis has already made an impact on our understanding of the heterogeneity of CAFs. Here, we review the recent literature on CAF heterogeneity and function, and discuss the possibility of novel therapies targeting CAF subsets.
Abundant Expression of Granzyme A, but Not Perforin, in Granules of CD8+ T Cells in GALT: Implications for Immune Control of HIV-1 Infection (2004)

Because GALT is a major portal of entry for HIV-1 and reservoir for viral replication, we hypothesized that an ineffective cellular immune response in intestinal mucosa might partially explain the failure of immune control in AIDS. In this study, we demonstrate that the vast majority of CD8+ T cells in rectal tissue, including HIV-1-specific cells, fail to express the cytolytic protein, perforin. However, rectal CD8+ T cells do express granzyme A, and are also capable of releasing IFN-gamma upon stimulation with cognate peptide. Confocal microscopy showed that granzyme A was located in intracellular granules in the absence of perforin. The majority of rectal CD8+ T cells exhibit an effector memory phenotype, expressing CD45RO but not CCR7. Quantitative real-time PCR analysis demonstrated that perforin RNA is expressed in rectal CD8+ T cells from healthy and HIV-1-positive individuals. In HIV-1-positive individuals, similar amounts of perforin RNA were detected in CD8+ T cells from rectal tissue and PBMC, despite a relative absence of perforin protein in rectal tissue. These findings demonstrate an important difference in perforin expression between CD8+ T cells in blood and mucosa. Furthermore, the relative absence of armed effector cells may serve to protect the integrity of rectal mucosa under normal conditions, but might also provide an early advantage to HIV-1 and other sexually transmitted viruses.
In situ SEM Study and Microstructural Evolution of Nano Si anode for Li-ion Technology (2014)

International audience
Anagrelide for Gastrointestinal Stromal Tumor (2018)

PDE3A and PDE3B are frequently expressed in GIST. Anagrelide had anticancer efficacy in GIST xenograft models and warrants further testing in clinical trials.
An vector automatic matching system designed for wireless medical telemetry (2008)

A novel adaptive antenna impedance matching system based on vector detection method for medical telemetry is proposed. The system controls a pi matching network tunable components by detecting the antenna complex impedance. The antenna complex impedance is extracted in order to set the proper state configuration of the tunable matching network with basic calculation. Only 10 mus tuning time is required and 30 dB improvement of return loss is obtained. The emitterpsilas power and the receiverpsilas sensitivity can be optimized whatever the perturbations on the wireless link. The whole system has been simulated on a 2.4 GHz ISM emitter.
Figure S2 from Stimulation of Oncogene-Specific Tumor-Infiltrating T Cells through Combined Vaccine and αPD-1 Enable Sustained Antitumor Responses against Established HER2 Breast Cancer (2023)

&lt;p&gt;Supplementary Figure 2&lt;/p&gt;
A System for MRI-guided Prostate Interventions (2006)

Numerous studies have demonstrated the efficacy of image-guided needle-based therapy and biopsy in the management of prostate cancer. Magnetic resonance imaging (MRI) is an ideal modality for guiding and monitoring such interventions due to its excellent visualization of the prostate, its sub-structure and surrounding tissues. However, the accuracy of needle placement is limited by image fidelity, needle template guides, needle deflection and tissue deformation. We present a preliminary study of the key sources of needle placement error in actual clinical cases. To address these errors, we have designed a comprehensive robotic assistant system with the following features: high-fidelity MRI imaging, advanced planning and targeting with statistical anatomical atlases and multi-parametric imaging, improved navigation based on direct image feedback, and steady needle placement with a robotic manipulator. The prostate biopsy and brachytherapy procedures are to be performed entirely inside a 3T closed-bore MRI scanner. We present a detailed design of the robotic manipulator and associated planning and targeting systems
Cable suspended planar robots with redundant cables: controllers with positive tensions (2005)

Cable-suspended robots are structurally similar to parallel actuated robots but with the fundamental difference that cables can only pull the end-effector but not push it. From a scientific point of view, this feature makes feedback control of cable-suspended robots more challenging than their counterpart parallel-actuated robots. In the case with redundant cables, feedback control laws can be designed to make all tensions positive while attaining desired control performance. This paper presents approaches to design positive tension controllers for cable suspended robots with redundant cables. Their effectiveness is demonstrated through simulations and experiments on a three degree-of-freedom cable suspended robots.
Influenza vaccination in the elderly boosts antibodies against conserved viral proteins and egg-produced glycans (2021)

Seasonal influenza vaccination elicits a diminished adaptive immune response in the elderly, and the mechanisms of immunosenescence are not fully understood. Using Ig-Seq, we found a marked increase with age in the prevalence of cross-reactive (CR) serum antibodies that recognize both the H1N1 (vaccine-H1) and H3N2 (vaccine-H3) components of an egg-produced split influenza vaccine. CR antibodies accounted for 73% ± 18% of the serum vaccine responses in a cohort of elderly donors, 65% ± 15% in late middle-aged donors, and only 13% ± 5% in persons under 35 years of age. The antibody response to non-HA antigens was boosted by vaccination. Recombinant expression of 19 vaccine-H1+H3 CR serum monoclonal antibodies (s-mAbs) revealed that they predominantly bound to non-HA influenza proteins. A sizable fraction of vaccine-H1+H3 CR s-mAbs recognized with high affinity the sulfated glycans, in particular sulfated type 2 N-acetyllactosamine (Galβ1-4GalNAcβ), which is found on egg-produced proteins and thus unlikely to contribute to protection against influenza infection in humans. Antibodies against sulfated glycans in egg-produced vaccine had been identified in animals but were not previously characterized in humans. Collectively, our results provide a quantitative basis for how repeated exposure to split influenza vaccine correlates with unintended focusing of serum antibody responses to non-HA antigens that may result in suboptimal immunity against influenza.
Substrate-aware mixed-signal macrocell placement in WRIGHT (1995)

We describe a set of placement algorithms for handling substrate coupled switching noise. A typical mixed-signal IC has both sensitive analog and noisy digital circuits, and the common substrate parasitically couples digital switching transients into the sensitive analog regions of the chip. To preserve the integrity of sensitive analog signals, it is thus necessary to electrically isolate the analog and digital. We argue that optimal area utilization requires such isolation be designed into the system during first-cut chip-level placement. We present algorithms that incorporate commonly used isolation techniques within an automatic placement framework. Our substrate-noise evaluation mechanism uses a simplified substrate model and simple electrical representations for the noisy digital macrocells. The digital/analog interactions determined through these models are incorporated into a simulated annealing macrocell placement framework. Automatic placement results indicate these substrate-aware algorithms allow efficient mixed-signal placement optimization.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Isolation of Bis-Indole Alkaloids with Antileishmanial and Antibacterial Activities fromPerschiera van heurkii(Syn.Tabernaemontana van heurkii) (1994)

Extracts from leaves and stem bark of Peschiera van heurkii (Muell. Arg.) L. Allorge (syn. Tabernaemontana van heurkii Muell. Arg., Apocynaceae) have been assayed for antileishmanial and antibacterial activities. The activities were concentrated in the alkaloid fractions which yielded 20 indole and bisindole alkaloids. The strongest leishmanicidal and antibacterial activities were observed with the dimeric alkaloids conodurine (1), N-demethylconodurine (= gabunine) (2), and conoduramine (3). Weak toxicity towards macrophage host cells and strong activity against the intracellular amastigote form of Leishmania were observed for compounds 1 and 2. In vivo, 1 was less active than glucantime (= N-methylglucamine antimonate), the drug of reference, while 2 was devoid of activity at 100 mg/kg.
Preparo de nanocompósitos de poli(succinato de butileno) (PDS) e argila motmorilonita organofílica via polimerização in situ (2014)

Nanocompósitos de poli(succinato de butileno) (PBS) e argila montmorilonita organofílica foram sintetizados via polimerização in situ, em três diferentes concentrações (4, 6 e 8% em massa). Os produtos obtidos foram caracterizados por diversas técnicas. Entre elas, a difração de raios X foi útil para comprovar o aumento do espaçamento interlamelar da argila devido à incorporação das cadeias de polímero. As técnicas de análise térmica mostraram que o método de polimerização in situ gerou materiais com menores estabilidades térmicas, comparadas ao polímero puro, devido à dificuldade de crescimento das cadeias de polímero na presença da argila. A técnica de RMN de baixo campo permitiu identificar que a estrutura esfoliada predomina nos nanocompósitos.