gebhart/patrepeval huggingface dataset:
Thin-film High Voltage Capacitors for Hybrid Electric Vehicle Inverter Applications (2012)

The propulsion system in hybrid electric vehicles (HEVs) requires an alternating current (AC) electric motor in combination with an internal combustion engine. When the HEV is being propelled by the AC motor, the power for the motor is provided by batteries whose direct current (DC) voltage is chopped into an AC waveform via an electronic device called a power inverter. Capacitors known as DC bulk capacitors are placed between the battery and the inverter to “decouple” the AC switching inverter from the power source. Power electronics inverters use several large high voltage discrete DC bulk capacitors, which negatively influence the inverter's size, weight and are a high cost item in the assembly. The use of a high dielectric constant (Dk) ferroelectric material enables smaller, higher temperature capable, lower-cost power capacitors. Ceramic ferroelectrics, such as (Pb,La)(Zr,Ti)O3 [PLZT], offer the highest dielectric constants. Argonne National Laboratory is developing a novel film-on-foil technology for high-power capacitors utilizing PLZT. These capacitors, with an increasing dielectric constant with temperature, low equivalent series resistance and a benign failure mode, are well suited for power applications. The PLZT is deposited onto a metal foil via a chemical deposition process and the top electrode metal (Pt or Al) is then deposited by electron beam evaporation onto the top surface of the dielectric thus creating the capacitor. This project involved the fabrication and electrical evaluation of film-on-foil capacitors for HEV inverter applications. Capacitors utilizing both nickel and platinum-on-silicon as the base substrate, and PLZT as the dielectric material were fabricated. These capacitors were tested for dielectric integrity, capacitance, voltage breakdown, and benign failure mode. Results from these mechanical and electrical evaluation tests will be presented. Key processing challenges and implementation methods will also be described.
Data from Transcriptional Analysis of an E2F Gene Signature as a Biomarker of Activity of the Cyclin-Dependent Kinase Inhibitor PHA-793887 in Tumor and Skin Biopsies from a Phase I Clinical Study (2023)

&lt;div&gt;Abstract&lt;p&gt;A transcriptional signature of the pan–cyclin-dependent kinase (Cdk) inhibitor PHA-793887 was evaluated as a potential pharmacodynamic and/or response biomarker in tumor and skin biopsies from patients treated in a phase I clinical study. We first analyzed the expression of a number of known E2F-dependent genes that were predicted to be modulated after Cdk2 and Cdk4 inhibition in xenograft tumor and skin samples of mice treated with the compound. This panel of 58 selected genes was then analyzed in biopsies from seven patients treated with PHA-793887 in a phase I dose escalation clinical trial in solid tumors. Quantitative real-time PCR or microarray analyses were done in paired skin and tumor biopsies obtained at baseline and at cycle 1. Analysis by quantitative real-time PCR of the signature in skin biopsies of patients treated at three different doses showed significant transcriptional downregulation with a dose-response correlation. These data show that PHA-793887 modulates genes involved in cell cycle regulation and proliferation in a clinical setting. The observed changes are consistent with its mechanism of action and correlate with target modulation in skin and with clinical benefit in tumors. Mol Cancer Ther; 9(5); 1265–73. ©2010 AACR.&lt;/p&gt;&lt;/div&gt;
A New Shared Spectrum Access Paradigm between Cellular Wireless Communications and Radio Astronomy (2016)

This paper proposes a new paradigm of shared spectrum access between cellular wireless communications (CWC) and radio astronomy systems (RAS). Traditionally, most spectrum chunks are separately allocated to CWC and RAS, with a few shared spectrum without guaranteed spectrum access for RAS. Furthermore, RAS sites are generally set up at remote locations, protected by radio quiet zones. In view of growths in spectrum demands from both systems, in population, and in applications and service deployments, the existing paradigm of geographical and spectral isolation between CWC and RAS will become inefficient. This paper develops a three phase spectrum access which enables geographical and spectral coexistence between CWC and RAS. Additionally, traffic statistics based improved spectrum access is developed. Furthermore, a built-in fine tuning mechanism is presented for addressing mismatches between design and practical environments as well as for facilitating service evolutions. Performance evaluation results demonstrate advantages of the proposed paradigm.
From Small X to Large X: Assessment of Space-Filling Criteria for the Design and Analysis of Computer Experiments (2006)

There has been much written about the use of -filling designs for the design and analysis of computer experiments. These designs are generally considered a more appropriate alternative to traditional orthogonal designs, which are optimal for constructing pure 2 nd order polynomial models, since there is no assumed underlying model f orm. However, much of the literature has focused on assessment of these designs where the number of input variables is typically 10 -20 (or less). In addition, the notion of space - is not clearly defined in the sense that it is purely correlated w ith a single specific uniformity criterion. In this paper, we describe simulation comparisons of different - filling designs of up to 100 input X's using different assessment critieria.
The Upcoming Epidemic of Heart Failure in South Asia (2020)

Currently, South Asia accounts for a quarter of the world population, yet it already claims ≈60% of the global burden of heart disease. Besides the epidemics of type 2 diabetes mellitus and coronary heart disease already faced by South Asian countries, recent studies suggest that South Asians may also be at an increased risk of heart failure (HF), and that it presents at earlier ages than in most other racial/ethnic groups. Although a frequently underrecognized threat, an eventual HF epidemic in the densely populated South Asian nations could have dramatic health, social and economic consequences, and urgent interventions are needed to flatten the curve of HF in South Asia. In this review, we discuss recent studies portraying these trends, and describe the mechanisms that may explain an increased risk of premature HF in South Asians compared with other groups, with a special focus on highly relevant features in South Asian populations including premature coronary heart disease, early type 2 diabetes mellitus, ubiquitous abdominal obesity, exposure to the world's highest levels of air pollution, highly prevalent pretransition forms of HF such as rheumatic heart disease, and underdevelopment of healthcare systems. Other rising lifestyle-related risk factors such as use of tobacco products, hypertension, and general obesity are also discussed. We evaluate the prognosis of HF in South Asian countries and the implications of an anticipated HF epidemic. Finally, we discuss proposed interventions aimed at curbing these adverse trends, management approaches that can improve the prognosis of prevalent HF in South Asian countries, and research gaps in this important field.
Parallel alignment of bacteria using near-field optical force array for cell sorting (2017)

This paper presents a near-field approach to align multiple rod-shaped bacteria based on the interference pattern in silicon nano-waveguide arrays. The bacteria in the optical field will be first trapped by the gradient force and then rotated by the scattering force to the equilibrium position. In the experiment, the Shigella bacteria is rotated 90 deg and aligned to horizontal direction in 9.4 s. Meanwhile, ~150 Shigella is trapped on the surface in 5 min and 86% is aligned with angle &lt;; 5 deg. This method is a promising toolbox for the research of parallel single-cell biophysical characterization, cell-cell interaction, etc.
Table S5 from Anti-PSMA/CD3 Bispecific Antibody Delivery and Antitumor Activity Using a Polymeric Depot Formulation (2023)

&lt;p&gt;Blood count parameters quantification in BALB/c mice after injection of TB1/DB4&lt;/p&gt;
RETRACTED: Effect of antenatal magnesium sulphate on MRI biomarkers of white matter development at term equivalent age: The magnum study (2020)

Health Research Council of New Zealand.
Supplementary Figure 4 from XPO1 (CRM1) Inhibition Represses STAT3 Activation to Drive a Survivin-Dependent Oncogenic Switch in Triple-Negative Breast Cancer (2023)

&lt;p&gt;PDF file - 51K, Knockdown of XIAP has no effect on survivin degradation.&lt;/p&gt;
Redistribution of Total Temperature Through an Annular Turbine Nozzle Cascade (2018)

Flow exiting the combustor is highly turbulent and contains significant spatial gradients of pressure and temperature. The high pressure turbine nozzle vanes operating in this environment redistribute these spatial gradients and impact the inflow characteristics of the turbine rotor blades. The present study investigates the redistribution of total temperature through a turbine nozzle vane. Numerical investigation was performed using three-dimensional RANS analysis. Simulations were conducted using the Wilcox k–ω turbulence model and Shear Stress Transport (SST) with and without γ–Reθ transition model. Experimental measurements were obtained in an annular nozzle cascade facility. Two sets of inlet conditions were considered. The first was a nominally uniform total temperature. The second had a span-wise variation of total temperature. Both sets of inlet conditions had nominally the same inlet total pressure and inlet Mach number. Span-wise redistribution was evaluated using the circum-ferentially averaged total temperature profile at a plane downstream of the nozzle. Physical arguments about the influence of nozzle secondary flows on this redistribution are presented.
Synthesis and Membrane Properties of Sulfonated Poly(arylene ether sulfone) Statistical Copolymers for Electrolysis of Water: Influence of Meta- and Para-Substituted Comonomers (2017)

Two series of high molecular weight disulfonated poly(arylene ether sulfone) random copolymers were synthesized as proton exchange membranes for high-temperature water electrolyzers. These copolymers differ based on the position of the ether bonds on the aromatic rings. One series is comprised of fully para-substituted hydroquinone comonomer, and the other series incorporated 25 mol % of a meta-substituted comonomer resorcinol and 75 mol % hydroquinone. The influence of the substitution position on water uptake and electrochemical properties of the membranes were investigated and compared to that of the state-of-the-art membrane Nafion. The mechanical properties of the membranes were measured for the first time in fully hydrated conditions at ambient and elevated temperatures. Submerged in water, these hydrocarbon-based copolymers had moduli an order of magnitude higher than Nafion. Selected copolymers of each series showed dramatically increased proton conductivities at elevated temperature in fully hydrated conditions, while their H<sub>2</sub> gas permeabilities were well controlled over a wide range of temperatures. These improved properties were attributed to the high glass transition temperatures of the disulfonated poly(arylene ether sulfone)s.
AT-Cut Quartz Piezoelectric Transformers for Passive Voltage Gain in an RF Front-End (2019)

The purpose of this work is to assess the performance of an AT-cut quartz device as a two-port resonant transformer for near-zero power-consuming wake-up receiver applications. The device consists of two, coupled thickness-shear mode trapped-energy ~50 MHz resonators on a single quartz substrate. Passive voltage gain up to 84 V/V (referenced to 50Ω) is observed when the device is driven by a low-power signal (≤ -30 dBm) at resonance. This transformer offers high voltage gain suitable for use in the front-end of a near-zero-power wake-up receiver. Additionally, this work shows that connecting two coupled-resonator quartz devices in a parallel-input, series-output (PISOT) configuration provides improvements in voltage gain. A 17% increase in gain is demonstrated for PISOT over that of a single coupled resonant transformer for various load impedances. This work is the first use of quartz piezoelectric transformers (PTs) for passive voltage gain, and the highest open-circuit gain demonstrated in a two-port micromechanical PT.
Split immunoglobulin genes and human heavy chain deletion-mutants. (1979)

In 1965, the “two gene-one polypeptide” theory for the synthesis of antibody chains was first proposed (1). Since then, amino acid sequence studies and genetic analyses of the variable (V) 2 and constant (C) regions of light (L) and heavy (H) chains have been consistent with this hypothesis (2). A direct demonstration of the existence of separate genetic units was achieved in 1977 (3), when it was shown that the DNA segments (exon DNA) coding for V and C regions of mouse L chains (λ type) are separated from one another by a large DNA segment (intron or intervening sequence or IVS) that is missing from the mRNA that serves as the template for the L chain. In addition, in DNA derived from embryonic cells, the V gene is shorter than expected (4, 5), ending at the codon specifying position 98 instead of 112 commonly accepted at the VC joining region.
Ultra long-term sodium balance studies during the Mars500 campaign (2012)

Continuous Glucose Monitoring Following Consumption of Everyday Foods and their Effect on Postprandial Glucose and Insulin Levels
Classic Meets Modern (2020)

These days, taking the revolutionary approach of using clean-slate learning-based designs to completely replace the classic congestion control schemes for the Internet is gaining popularity. However, we argue that current clean-slate learning-based techniques bring practical issues and concerns such as overhead, convergence issues, and low performance over unseen network conditions to the table. To address these issues, we take a pragmatic and evolutionary approach combining classic congestion control strategies and advanced modern deep reinforcement learning (DRL) techniques and introduce a novel hybrid congestion control for the Internet named Orca1. Through extensive experiments done over global testbeds on the Internet and various locally emulated network conditions, we demonstrate that Orca is adaptive and achieves consistent high performance in different network conditions, while it can significantly alleviate the issues and problems of its clean-slate learning-based counterparts.
The 5S rRNA and the rRNA intergenic spacer of the two varieties ofCryptococcus neoformans (1995)

The intergenic spacers (IGS) separating the 23S-like and 16S-like rDNAs of the two varieties of the human pathogenic fungus Cryptococcus neoformans were amplified, cloned and sequenced. The C. neoformans var. neoformans IGS was 2421 nt with 5S rRNA at positions 1228-1345 3' of the 23S-like rRNA. The C. neoformans var. gattii IGS was 2480 nt with 5S rRNA at positions 1268-1385 3' of the 23S-like rRNA. For both varieties the 5S rDNA genes were in the same orientation as the 16S-5.8-23S genes and encode a 118 nt molecule of identical sequence. Phylogenetic comparison of C. neoformans 5S rDNA with that of other fungi placed this fungus in close relationship with other basidiomycetes including Tremella mesenterica, Bullera alba, and Cryptococcus laurentii. A secondary structure model for the deduced 5S rRNA was constructed by comparative sequence analysis. Polymerase chain reaction-amplified IGS of 12 C. neoformans var. neoformans strains revealed extensive size variation ranging from 100 to 300 nt. Size variation between strains in the length of the IGS may be useful for distinguishing strains. Structurally, the IGS were characterized by the presence of occasional short direct GC-rich 19-nt repeats. Overall IGS sequence identity between the C. neoformans varieties was only 78.5%, in sharp contrast to the identical or nearly identical sequences for the rDNA genes, and suggests rapid evolution for IGS sequences.
Amphiphilic Co-Solvents Modulate the Structure of Membrane Domains (2023)

Biofuels are an increasing part of the sustainable energy picture. This makes it a societal and economic imperative to optimize biofuel production. Mitigating the toxic effects of amphiphilic co-solvents is one way to improve the efficiency of biofuel production. Amphiphiles partition into cellular membranes, leading to membrane thinning, destabilization, loss of membrane potential, and, ultimately, cell death. However, this picture of solvent toxicity misses the disruptive impact of co-solvents on lateral membrane organization, which is increasingly recognized as critical for membrane protein sorting and oligomerization. The alteration or disruption of membrane domains has deleterious effects on cellular processes. In this work, we pursue the hypothesis that membrane lateral organization is disrupted by the presence of co-solvents at concentrations lower than those which lead to full membrane destabilization. The disruption occurs due to an increasing interfacial tension between the co-existing phases, resulting in conformational changes to minimize the interfacial length-to-area ratio. This represents an unrecognized mode of solvent-induced stress and a new target for interventions to improve fermentation yields.
Genetic Diagnosis and the Severity of Cardiovascular Phenotype in Patients With Elastin Arteriopathy (2020)

Patients with nonsyndromic SVAS require early and more frequent vascular and valvular interventions and reinterventions, in particular for concomitant valvar aortic stenosis compared with patients with WBS. This provides important prognostic information to guide counseling of affected families with cardiovascular disease and may guide primary intervention strategies based on predicted risk of restenosis.
Tunable Bandpass Filter With Two Adjustable Transmission Poles and Compensable Coupling (2014)

In this paper, tunable microstrip bandpass filters with two adjustable transmission poles and compensable coupling are proposed. The fundamental structure is based on a half-wavelength (λ/2) resonator with a center-tapped open-stub. Microwave varactors placed at various internal nodes separately adjust the filter's center frequency and bandwidth over a wide tuning range. The constant absolute bandwidth is achieved at different center frequencies by maintaining the distance between the in-band transmission poles. Meanwhile, the coupling strength could be compensable by tuning varactors that are side and embedding loaded in the parallel coupled microstrip lines (PCMLs). As a demonstrator, a second-order filter with seven tuning varactors is implemented and verified. A frequency range of 0.58-0.91 GHz with a 1-dB bandwidth tuning from 115 to 315 MHz (i.e., 12.6%-54.3% fractional bandwidth) is demonstrated. Specifically, the return loss of passbands with different operating center frequencies can be achieved with same level, i.e., about 13.1 and 11.6 dB for narrow and wide passband responses, respectively. To further verify the etch-tolerance characteristics of the proposed prototype filter, another second-order filter with nine tuning varactors is proposed and fabricated. The measured results exhibit that the tunable fitler with the embedded varactor-loaded PCML has less sensitivity to fabrication tolerances. Meanwhile, the passband return loss can be achieved with same level of 20 dB for narrow and wide passband responses, respectively.
Evolution and outcome in malignant astroglial neoplasms of the cerebellum (1985)

Malignant astroglial neoplasms of the cerebellum are rare and the clinical behavior of these tumors is unpredictable. The authors describe the histological characteristics and clinical outcome in 10 patients; eight had malignant cerebellar astrocytomas, and one each had an astroblastoma and a true polar spongioblastoma. Malignant glial tumors involving the cerebellum usually behave very aggressively. Cerebellar astroblastomas and polar spongioblastomas are too rare to predict their natural history. Some hypotheses are proposed concerning the evolution and interrelationship of malignant glial tumors of the cerebellum.
Visualizing the Effect of Microenvironment on the Spatiotemporal RhoA and Src Activities in Living Cells by FRET (2009)

The cell-microenvironment interaction is critical for cells to perceive environmental cues and co-ordinate signaling cascades to regulate physiological functions. Herein, a soft-lithography technique, micropattern via micromolding in capillaries (MIMIC), is explored to create cell-adhesive micropatterns on glass coverslips. Genetically encoded Src and RhoA fluorescence resonance energy transfer (FRET) biosensors are used to monitor the Src and RhoA activities in nonpatterned cells (stochastically migrating cells, SMCs) and those constrained to grow on micropatterned surfaces (restrictedly migrating cells, RMCs). The results reveal that epidermal growth factor (EGF) induces a decrease of RhoA and an increase of Src activities with biphasic time courses in RMCs. In contrast, the time courses of such activities in SMCs upon EGF stimulation are relatively monophasic. The inhibition of Src activity, actin network, or myosin machinery abolishes the biphasic RhoA response upon EGF stimulation in RMCs. The results indicate that this microenvironment effect on the biphasic RhoA activation in RMCs is mediated by Src and actomyosin machinery. Through the integration of FRET and micropatterning technologies, it is demonstrated that the microenvironment impacts significantly on cell shapes and subsequently the spatiotemporal signaling network of RhoA and Src in living cells. The results help to advance mechanistic understanding of how cells perceive and interpret microenvironments to co-ordinate intracellular molecular signals and ultimately physiological responses.
Examining platelet–fibrin interactions during traumatic shock in a swine model using platelet contractile force and clot elastic modulus (2011)

A significant proportion of severely injured patients develop early coagulopathy, characterized by abnormal clot formation, which impairs resuscitation and increases mortality. We have previously demonstrated an isolated decrease in clot strength by thrombelastography in a swine model of nonresuscitated traumatic shock. In order to more closely examine platelet-fibrin interactions in this setting, we define the observed decrease in clot strength in terms of platelet-induced clot contraction and clot elastic modulus using the Hemostasis Analysis System (HAS) (Hemodyne Inc., Richmond, Virginia, USA). Whole blood was sampled for HAS measurements, metabolic measurements, cell counts, and fibrinogen concentration at baseline prior to injury and again at a predetermined level of traumatic shock defined by oxygen debt. Male swine (N=17) received femur fracture and controlled arterial hemorrhage to achieve an oxygen debt of 80 ml/kg. Platelet counts were unchanged, but fibrinogen concentration was reduced significantly during shock (167.6 vs. 66.7 mg/dl, P=0.0007). Platelet contractile force generated during clot formation did not change during shock (11.7 vs. 10.4 kdynes, P=0.41), but clot elastic modulus was dynamically altered, resulting in a lower final value (22.9 vs. 17.3 kdynes/cm, P<0.0001). In this model of traumatic shock, platelet function was preserved, whereas terminal clot elastic modulus was reduced during shock in a manner most consistent with early changes in the mechanical properties of the developing fibrin fiber network.