gebhart/patrepeval huggingface dataset:
Defect-Mediated Properties of Magnetic Tunnel Junctions (2007)

Defects play an important role in the properties of metal oxides which are currently used as barrier layers in magnetic tunnel junctions (MTJs). We study the effect of O vacancies on the interlayer exchange coupling (IEC) and tunneling magnetoresistance (TMR) in Fe-MgO-Fe tunnel junctions. Measurements of IEC in fully epitaxial Fe-MgO-Fe(001) tunnel junctions show IEC is antiferromagnetic (AFM) for small MgO thickness but changes sign and then vanishes for large barrier thickness. First-principles calculations based on density functional theory demonstrate that the presence of neutral O vacancies (F-centers) in the MgO barrier can explain this behavior. Resonant tunneling through the F-centers makes IEC AFM for thin barriers but with increasing MgO thickness the resonance contribution to IEC is reduced resulting in the ferromagnetic (FM) coupling typical for perfect MgO barriers. First-principles calculations also show that O vacancies can affect TMR. F-centers produce occupied localized s-states and unoccupied resonant p-states in the gap of MgO. We demonstrate that F-centers affect the conductance by either resonant transmission or nonresonant scattering of tunneling electrons both causing a substantial reduction of TMR compared to the ideal case
Core–shell clusters of human haemoglobin A and human serum albumin: artificial O2-carriers having various O2-affinities (2015)

This report describes the synthesis, structure, and O<sub>2</sub>-binding properties of core-shell clusters composed of human haemoglobin A (HbA) in the centre and human serum albumin (HSA) at the periphery (HbA-HSA<sub>m</sub>) as potential O<sub>2</sub>-carriers designed as red blood cell (RBC) substitutes. Protein clusters were prepared by covalent linkages between HbA lysins and HSA cysteine-34 using a heterobifunctional cross-linker, succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate. Major products (m = 2, 3, 4) were isolated using gel filtration chromatography. The low isoelectric points (pI = 5.0-5.2) of the clusters were almost identical to that of HSA, proving the wrapping of HbA by negatively charged HSA. The 3D reconstruction of HbA-HSA<sub>3</sub> based on transmission electron microscopy images revealed a complete triangular structure. The proposed geometries enabled us to assign a possible spatial arrangement of the HbA centre and HSA periphery. The HbA-HSA<sub>m</sub> clusters showed higher O<sub>2</sub>-affinities (P<sub>50</sub> = 8-9 Torr) than the native HbA. The clusters prepared under N<sub>2</sub> atmosphere showed a low O<sub>2</sub>-affinity (P<sub>50</sub> = 26 Torr) resembling those of human RBC. Moreover, the cluster containing an αα-cross-linked HbA with bis(3,5-dibromosalicyl)fumarate showed a markedly low O<sub>2</sub>-affinity (P<sub>50</sub> = 35 Torr). These HbA-HSA<sub>m</sub> clusters with various O<sub>2</sub>-affinities can support a new generation of RBC substitutes, which can be better tuned to play a role in O<sub>2</sub> transport.
Unusual bone metastasis from follicular carcinoma thyroid: presenting as a primary bone malignancy (2014)

Osseous metastasis in patients of thyroid carcinoma is not very common, and appendicular skeleton is very rare. Bone metastasis represents a complication, especially of follicular thyroid carcinoma and severely reduces the quality of life causing pain, and fractures. Diagnosis is typically done by correlating clinical suspicion with imaging. Occult clinical presentations usually delay the detection and management of patients with bone metastasis from thyroid carcinoma. There is limited information about the clinical presentations and prognosis of patients with follicular thyroid carcinoma with bone metastasis. We hereby present a case report of right arm swelling diagnosed as metastatic carcinoma having metastasis from thyroid primary.
BASTION-SGX (2018)

This paper presents work towards realizing architectural support for Bluetooth Trusted I/O on SGX-enabled platforms, with the goal of providing I/O data protection that does not rely on system software security. Indeed, we are primarily concerned with protecting I/O from all software adversaries, including privileged software. In this paper we describe the challenges in designing and implementing Trusted I/O at the architectural level for Bluetooth. We propose solutions to these challenges. In addition, we describe our proof-of-concept work that extends existing over-the-air Bluetooth security all the way to an SGX enclave by securing user data between the Bluetooth Controller and an SGX enclave.
An attempt to understand flicker vertigo: changes in pupil size and choroidal blood flow under flickering conditions (2010)

Light flickering at a rate of 4- 20 cycles per second can produce unpleasant reactions such as nausea and vertigo. In this paper, the possibility of achieving an objective evaluation/prediction of the physiological effects induced by flicker is investigated using a new imaging method based on the pupil size determination. This method is also compared with the blood flow analysis in the choroid.
57. A DECADE OF NIPPLE-SPARING MASTECTOMY AND IMMEDIATE IMPLANT-BASED BREAST RECONSTRUCTION: LESSONS LEARNED (2022)

PURPOSE: Nipple-sparing mastectomy is commonly performed for breast cancer treatment or prevention. Prior outcomes research is limited by small sample size and conflicting data. We present one of the largest series in the literature for analysis. METHODS: Retrospective single institution review was conducted from 2007-2018. RESULTS: Our query found 2260 implant-based breast reconstructions after nipple-sparing mastectomy including 1508 direct-to-implant and 752 tissue expander-implant reconstructions. The average age was 47 and body mass index 24. The direct-to-implant cohort had more radiotherapy (17.6% vs. 13.2%, p=0.007) and chemotherapy (33.1% vs. 25.8%, p<0.001) while the tissue expander-implant group had more smokers (9.0% vs. 3.3%, p<0.001). Overall complications and nipple necrosis were higher in tissue expander reconstructions compared to direct to implant reconstruction (p<0.02 for each). Multivariable regression analysis revealed preoperative radiotherapy (OR 2.99, 95% C.I. 1.827-4.892, p<0.001), active smoking (OR 1.86, 95% C.I. 1.132-3.084), and periareolar incision (OR 3.528, 95% C.I. 1.399-8.893, p<0.001) to be the strongest predictors of overall complications and predictors of nipple necrosis (p<0.05). Tissue expander reconstruction had a significantly higher odds ratio for complications compared to direct-to-implant (OR 1.488, 95% C.I. 1.106-2.002, p=0.009). There was no difference in overall complications between reconstruction with acellular dermal matrix/ mesh compared to total or partial muscle coverage without ADM/mesh (OR 0.866, 95% C.I. 0.648-1.157, p=0.332). CONCLUSION: In this large series, radiation, smoking, and incision choice strongly predicted overall complications and nipple necrosis. Direct-to-implant reconstruction and reconstruction with acellular dermal matrix or mesh were not associated with an elevated risk of complications.
Highly Ordered Nanosphere Imprinted Nanochannel Alumina (NINA) (2004)

A nanoimprinting technique (not requiring nanoscale lithography) that is applied to the synthesis of highly ordered nanosphere imprinted nanochannel alumina (NINA) films (see Figure) is reported. The synthesis is effected by the anodic oxidation of nanoimprinted aluminum in phosphoric acid. Films with inter-pore distances ranging between 80 nm and 500 nm are produced using this approach.
Abstract 1908: The Wnt-target Prox1 promotes colorectal cancer stem cell survival to fuel tumor growth (2014)

Abstract Colorectal cancer (CRC) is one of the leading causes of cancer mortality in the Western countries. In most of the CRC patients, an initial mutation occurs in the APC or CTNNB1 genes, leading to the ligand-independent activation of the canonical Wnt pathway. Besides having a central role in the development of CRC, the Wnt pathway plays a critical role also in the maintenance of the normal intestine. Attempts at therapeutic inhibition of this pathway could thus lead to serious side effects in CRC patients. We have previously shown that the Prox1 transcription factor is induced in the intestinal epithelium by mutations activating the Wnt pathway and it critically contributes to CRC progression via an unknown mechanism. Here we provide evidence that Prox1 expression is induced in the Lgr5+ adenoma stem cells early after Apc deletion. Our in vivo models and ex vivo organoid experiments suggest that Prox1 silencing or deletion restricts the expansion of the Lgr5+ adenoma stem cell population both in humans and in mice. Interestingly, silencing the phospholipid binding protein Annexin A1 (Anxa1), a gene suppressed by Prox1, is responsible for several of the effects of Prox1 on adenoma cells, such as the re-organization of the actin cytoskeleton, enhanced stem cell activity and tumor growth. Furthermore, Prox1 deletion abnormally increases the mTORC1 pathway activity, which results in decreased survival of the adenoma stem cells. Since Prox1 is expressed at low level only in rare neuroendocrine cells and in some Paneth cells in the wild type intestinal epithelium, furthermore, its genetic deletion in the adult gut does not lead to obvious phenotypes, Prox1 may serve as an attractive therapeutic target for restricting the progression of early intestinal adenomas. Citation Format: Zoltan Wiener, Ville Hyvönen, Jenny Högström, Tanja Holopainen, Arja Band, Pauliina Kallio, Olli Dufva, Caj Haglund, Olli Kruuna, Guillermo Oliver, Yinon Ben-Neriah, Kari Alitalo. The Wnt-target Prox1 promotes colorectal cancer stem cell survival to fuel tumor growth. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1908. doi:10.1158/1538-7445.AM2014-1908
Laser surface preparation for bonding of aerospace composites (2011)

Adhesive bonds are critical to the integrity of built-up structures. Disbonds can often be detected but the strength of adhesion between surfaces in contact cannot be determined without destructive testing. Typically the major problem in a bonded structure is surface contamination, and by extension, surface preparation. Standard surface preparation techniques, including grit blasting, manual abrasion, and peel ply, are not ideal because of variations in their application. Etching of carbon-fibre-reinforced plastic (CFRP) panels using a neodymium-doped yttrium aluminum garnet (Nd:YAG) laser appears to be a highly precise, controlled, and reliable way to both clean a composite surface prior to bonding and provide a bond-promoting patterned surface akin to peel ply without the inherent drawbacks from the same (i.e. debris and curvature). CFRP surfaces prepared using laser patterns conducive to adhesive bonding were compared with typical pre-bonding surface treatments through optical microscopy, contact angle goniometry and post-bonding mechanical testing. This paper is the work of the US Government and is not subject to copyright protection in the USA.
Enzymic cyclization of hydroxylated surrogate squalenoids with bakers' yeast (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnzymic cyclization of hydroxylated surrogate squalenoids with bakers' yeastJulio C. Medina and Keith S. KylerCite this: J. Am. Chem. Soc. 1988, 110, 14, 4818–4821Publication Date (Print):July 1, 1988Publication History Published online1 May 2002Published inissue 1 July 1988https://pubs.acs.org/doi/10.1021/ja00222a046https://doi.org/10.1021/ja00222a046research-articleACS PublicationsRequest reuse permissionsArticle Views176Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Reduction of Influence of Inter-core Cross-talk in MCF with Bidirectional Assignment between Neighboring Cores (2013)

We evaluated the effects of bidirectional signal assignment between neighboring cores in MCF for the reduction of inter-core cross-talk with 98-km MCF. We clarify its advantage and several specific limiting factors.
Antimelanoma CTL recognizes peptides derived from an ORF transcribed from the antisense strand of the 3′ untranslated region of TRIT1 (2014)

Noncoding regions of the genome play an important role in tumorigenesis of cancer. Using expression cloning, we have identified a cytotoxic T lymphocyte (CTL)-defined antigen that recognizes a protein sequence derived from an open reading frame transcribed from the reverse strand in the 3' untranslated region of tRNA isopentenyltransferase 1 (TRIT1). A peptide derived from this open reading frame (ORF) sequence and predicted to bind to HLA-B57, sensitized HLA-B57(+) tumor cells to lysis by CTL793. The peptide also induced a CTL response in peripheral blood mononuclear cells (PBMC) of patient 793 and in two other melanoma patients. The CTL lysed peptide-pulsed HLA-B57(+) target cells and melanoma cells with endogenous antigen expression. The recognition of this antigen is not limited to HLA-B57-restricted CTLs. An HLA-A2 peptide derived from the ORF was able to induce CTLs in PBMC of 2 HLA-A2(+) patients. This study describes for the first time a CTL-defined melanoma antigen that is derived from an ORF on the reverse strand of the putative tumor suppressor gene TRIT1. This antigen has potential use as a vaccine or its ability to induce CTLs in vitro could be used as a predictive biomarker.
p38 MAP Kinase Regulation of AP‐2 Binding in TGF‐β1‐Stimulated Chondrogenesis of Human Trabecular Bone‐Derived Cells (2002)

Collagenase-treated, explanted human trabecular-bone chips are an excellent source of osteoblast-like cells. We have recently shown the multiple differentiation potential of these cells; in addition to osteogenesis and adipogenesis, these cells also undergo chondrogenesis when maintained as high-density pellet cultures (250,000 cells/pellet) in a serum-free, chemically defined medium stimulated with TGF-beta1 (10 ng/mL). In this investigation, we have analyzed how transactivating nuclear transcription factors, specifically AP-2 and SP-1, may interact with common cis-acting elements found in the regulatory region of cartilage-specific genes as part of the signal transduction mechanism of TGF-beta1 and p38 during chondrogenesis of human trabecular bone-derived multipotential cells. Both TGF-beta1 stimulation and p38 MAP kinase activation affect the binding of AP-2 as well as SP-1 to oligonucleotides with sequence similarity to the overlapping AP-2/SP-1 sites found in the putative 52-bp immediate upstream regulatory region and the 5'-untranslated region of the human aggrecan gene. Electrophoretic mobility shift assays show that TGF-beta1 treatment of the bone-derived cells inhibits AP-2 DNA binding but enhances the DNA binding ability of SP-1. Additionally, treatment of these TGF-beta1-stimulated cells with p38 MAP kinase inhibitor, SB203580, rescued the AP-2 DNA binding but did not affect SP-1 DNA binding. These findings indicate that AP-2 DNA binding is the target of both TGF-beta1 and p38 MAP kinase signaling pathways and suggest a possible signal transduction cascade whereby TGF-beta1 induction of chondrogenesis involves the activation of p38 MAP kinase and the subsequent inhibition of DNA binding by AP-2, thereby preventing the transcriptional repression of the aggrecan gene.
Dynamic-focusing microscope objective for optical coherence tomography (2006)

Optical Coherence Tomography (OCT) is a novel optical imaging technique that has assumed significant importance in bio-medical imaging in the last two decades because it is non-invasive and provides accurate, high resolution images of three dimensional cross-sections of body tissue, exceeding the capabilities of the current predominant imaging technique - ultrasound. In this paper, the application of high resolution OCT, known as optical coherence microscopy (OCM) is investigated for <i>in vivo</i> detection of abnormal skin pathology for the early diagnosis of cancer. A main challenge in OCM is maintaining invariant resolution throughout the sample. The technology presented is based on a dynamic focusing microscope imaging probe conceived for skin imaging and the detection of abnormalities in the epithelium. A novel method for dynamic focusing in the biological sample is presented using variable-focus lens technology to obtain three dimensional images with invariant resolution throughout the cross-section and depth of the sample is presented and discussed. A low coherence broadband source centered at near IR wavelengths is used to illuminate the sample. The design, analysis and predicted performance of the dynamic focusing microscope objective designed for dynamic three dimensional imaging at 5&#956;m resolution for the chosen broadband spectrum is presented.
Footprint coverage comparison between knotted and knotless techniques in a single-row rotator cuff repair: biomechanical analysis (2019)

Basic Science Study, Biomechanics.
Influence of Pore Size and Pore Size Distribution of Polymer-Based Packing Materials on Chromatographic Separation of Carbon Clusters (1993)

Abstract Size monodispersed poly(styrene-divinylbenzene) particles with a variety of pore size and pore size distribution were prepared by a multi-step swelling and polymerization method and utilized as packing materials in high performance liquid chromatography (HPLC). As an application of these packing materials, separation of carbon clusters C60 and C70 were examined in a mixture of hexane and benzene and an influence of the pore size and the pore size distribution of the polymer-based packing materials on the separation was investigated. Although carbon clusters are sterically bulky molecules, packing materials with smaller pores showed better separation than those with larger pores. Completely separated peaks and the good peak shape suggest possible isolation of carbon clusters on relatively cheap polymer-based packing materials.
Oxygen-Carrying Cobaltporphyrin Complexed with Electroconductive Poly(3,4-azopyridylene) (1999)

Abstract Poly(3,4-azopyridylene) was prepared and complexed with picket-fence cobaltporphyrin; the polymer complex displayed both the selective and reversible oxygen-binding and the electroconductivity of 10−5 S cm−1.
Development of a silicon carbide radiation detector (1998)

The radiation detection properties of semiconductor detectors made of 4H silicon carbide were evaluated. Both Schottky and p-n junction devices were tested. Exposure to alpha particles from a /sup 238/Pu source led to robust signals from the detectors. The resolution of the Schottky SiC detector was 5.8% (FWHM) at an energy of 294 keV, while that of the p-n junction was 6.6% (FWHM) at 260 keV. No effect of temperature in the range of 22 to 89/spl deg/C was observed on the characteristics of the /sup 238/Pu alpha-induced signal from the SiC detector. In addition, testing in a gamma field of 10,000 rad-Si h/sup -1/ showed that the alpha-induced signal was separable from the gamma signal.
Does surgery for metastatic spinal tumors improve functional outcomes in patients without spinal cord compression but with potentially unstable spines (SINS 7–12)? (2023)

Patients with SINS values of 7-12 who underwent surgery had greater improvement in KPS scores-but not in ECOG scores-than patients undergoing radiation alone. In patients treated with radiation, treatment was converted to a procedural intervention such as surgery only in patients who sustained fractures. Of the patients with fractures after radiation (21 of 99), 5 patients underwent an invasive procedure and 16 did not.
ChemInform Abstract: IMINOPHOSPHORANE‐BENZOXAZAPHOSPHOLINE VALENCE TAUTOMERISM (1978)

Abstract Für das früher angenommene Gleichgewicht zwischen den beiden valenztautomeren Formen (I) und (II) in Lösung werden durch quantitative Untersuchung der temperaturabhängigen NMR‐ Spektren die Gleichgewichtskonstanten und die thermodynamischen Parameter ΔH, ΔG und ΔS bestimmt.
New visions for IC yield detractor detection (2017)

The observability of conventional electrical test site and imaging techniques needs to be extended and coupled with all of the actual product layout attributes in order to reflect the relevant yield detractors of the current technologies in production and development. This paper discusses new electrical test site strategies that have been recently developed and deployed developed for parametric yield detection and systematic hard defect detection by layout attribute. Such test structures are derived from the actual product and in some key cases also embedded in the product utilizing available space between the active circuitry and detected in-line with non-contact techniques.
Bis-penicillamine enkephalins possess highly improved specificity toward delta opioid receptors. (1983)

The conformationally restricted, cyclic, disulfide-containing, enkephalin analogs [2-D-penicillamine, 5-L-penicillamine]enkephalin [(D-Pen2,L-Pen5]enkephalin) and [2-D-penicillamine, 5-D-penicillamine]enkephalin [(D-Pen2,D-Pen5]enkephalin) were synthesized by solid-phase methods. Selectivities of these analogs for a single class of opioid receptor were investigated by examining relative potencies in the mouse vas deferens assay, in which the functional receptor is the delta receptor, versus the guinea pig ileum assay, in which the mu receptor is the functional receptor, and by determining their relative abilities to displace the prototypical delta receptor ligand [D-Ala2, D-Leu5]enkephalin and the prototypical mu receptor ligand naloxone from rat brain membrane preparations. Based on these comparisons [D-Pen2,L-Pen5]- and [D-Pen2,D-Pen5]enkephalin exhibited delta receptor selectivities of 1,088 and 3,164, respectively, in the bioassays, and 371 and 175, respectively, in the binding assays. Compared with the previously reported delta receptor selective analogs, [D-Ala2,D-Leu5]enkephalin, [D-Ser2,Leu5,Thr6]enkephalin, and [D-Thr2,Leu5,Thr6]enkephalin, the bis-Pen-containing analogs provide an order of magnitude increase in delta receptor selectivity.