gebhart/patrepeval huggingface dataset:
Development of a CaO-Based CO2 Sorbent with Improved Cyclic Stability (2008)

The carbonation of CaO is an attractive method for removing CO2 from hot gas mixtures. However, regeneration and reuse of a CaO-based sorbent causes a gradual decline in absorption capacity, which ultimately limits the life of the material. Various methods have been proposed for increasing the life cycle performance of a CaO-based sorbent. Two of these methods were selected for further investigation. One method incorporates an “inert” material in the sorbent, while a second method stabilizes the sorbent through controlled sintering. Promising results were achieved with both methods when they were applied separately to a sorbent derived from a natural limestone. In one case MgO was finely dispersed within the sorbent, where it served as an “inert” material in the sense that it did not absorb CO2. A concentration of approximately 20 wt % appeared to be nearly optimal. In a second case the sorbent was stabilized by calcining the material at 1100 °C for 5 h. Although neither method produced a completely stable material, the stability of the sorbents was improved sufficiently so that by the end of a 1200-cycle test the absorption capacity of either of the treated sorbents was 45% greater than that of an untreated sorbent and the rate of decline was very small.
A relevant in vitro rat model for the evaluation of blood-brain barrier translocation of nanoparticles (2005)

Poly(MePEG2000cyanoacrylate-co-hexadecylcyanoacrylate) (PEG-PHDCA) nanoparticles have demonstrated their capacity to reach the rat central nervous system after intravenous injection. For insight into the transport of colloidal systems across the blood-brain barrier (BBB), we developed a relevant in vitro rat BBB model consisting of a coculture of rat brain endothelial cells (RBECs) and rat astrocytes. The RBECs used in our model displayed and retained structural characteristics of brain endothelial cells, such as expression of P-glycoprotein, occludin and ZO-1, and immunofluorescence studies showed the specific localization of occludin and ZO1. The high values of transendothelial electrical resistance and low permeability coefficients of marker molecules demonstrated the functionality of this model. The comparative passage of polyhexadecylcyanoacrylate and PEG-PHDCA nanoparticles through this model was investigated, showing a higher passage of PEGylated nanoparticles, presumably by endocytosis. This result was confirmed by confocal microscopy. Thanks to a good in vitro/in vivo correlation, this rat BBB model will help in understanding the mechanisms of nanoparticle translocation and in designing new types of colloidal carriers as brain delivery systems.
Abstract LB-302: Inhibition of STAT3 following systemic delivery of STAT3 antisense oligonucleotide results in target inhibition in tumor and tumor-associated stromal cells and dramatic reduction in circulating pro-tumorigenic cytokines (2011)

Abstract Constitutive activation of STAT3 has been documented in a broad range of neoplastic tissues. STAT3 is a transcription factor that regulates the expression of numerous genes involved in the proliferation, survival, and metastasis of tumor cells. In addition, STAT3 contributes to tumorigenesis by modulating immune responses mediated by tumor stromal cells in the tumor microenvironment. The immuno-suppressive, pro-tumorigenic effects of STAT3 are regulated by induction or inhibition of several key cytokines. However STAT3 remains a difficult target to drug with conventional approaches. Here, we have studied the effects of selective downregulation of STAT3 in various cancer settings by optimized antisense oligonucleotides (ASOs). We assessed the effects of STAT3 downregulation on the expression of cytokines and the progression of cancer. Initially, the safety of inhibiting STAT3 was demonstrated in tolerability studies, where no notable toxicities were observed despite near complete abrogation of STAT3 expression in the liver following systemic delivery of ASO in both rodents and in non-human primate. ASO treatment led to STAT3 inhibition in tumor cells and several non-tumor stromal cell populations of the tumor. In addition, dramatic reduction in key pro-tumorigenic cytokines including IL-6 and IL-1b was observed in C26 colon cancer-bearing animals, which correlated with the decrease of STAT3 level in tumor and stromal cells. This result suggests that STAT3 might not only transmit the IL-6 signal from upstream pathway, but regulates IL-6 level possibly in an auto-feedback manner. Downregulation of STAT3 also led to the inhibition of IL-6-induced C-reactive protein (CRP) expression, which was recently reported to play a key role in the progression of multiple myeloma (MM). Moreover, inhibition of STAT3 resulted in a significant delay in tumor growth in STAT3-dependent MDA-MB-231 breast cancer and U251 glioblastoma xenograft models following systematic ASO treatment. The results from this study collectively suggest that STAT3 expression can be specifically modulated by ASOs in vivo tumor models and that in addition to effects in tumor cells STAT3 ASOs regulate the balance of tumorigenic cytokines in the tumor microenvironment. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr LB-302. doi:10.1158/1538-7445.AM2011-LB-302
Qualification of behavioral level design validation for AMS &#x00026; RF SoCs (2007)

The expansion of Wireless Systems-on-Chip leads to a rapid development of design and manufacturing methods In this paper, the test vectors used for design validation of AMS & RF SoCs are evaluated and optimized. This qualification is based on a fault injection method. A fault model based on variation of behavioral parameters and a related qualification metric are proposed. This approach is used in the receiver’s design of a WCDMA transceiver. A test set defined by verification engineers during the validation of this system is qualified and optimized. Then, this test set is compared with a second test set automatically generated by a developed tool.
Tortuosity Model of a Three-Dimensional Stacked Cylindrical Particles Porous Medium for Using with the Thin Film Solid Oxide Fuel Cell Electrodes (2012)

This work is precisely intended to derive an analytical model for tortuosity of streamlines in a three dimensional porous material of fuel cell electrodes, especially for the thin film electrode of solid oxide fuel cells. The arrangement of the particles that form the electrodes as the cylindrical particles stack, only arrange together in the vertical direction. The model is derived assuming and averaging over some possible streamlines around the particles and for the different particle configuration arrangements, and focuses only on the flow of a streamline passing the vertical stack cylinders. The present model is only dependent on distance between particles and particle sizes. The model predictions are successfully compared to the correlation obtained from available experiments in the literature, especially at high cylinder height to diameter ratios. There is agreement on the thin film electrode characteristics of solid oxide fuel cells. Keywords: analytical model, cylindrical particles stack, fuel cells, porous material, thin film
A Consultation in Workplace Incivility: The Deadly Inappropriate Smile (2020)

A deadly inappropriate smile is the focus in a consultation prompted by a public conflict between a heart surgeon and a patient's spouse. Following a failed heart-surgery the surgeon delivers the devastating news of the patient's death with a broad smile on his face. Outraged and deeply offended the wife of the deceased aggressively vows to purse formal grievances and a medical malpractice suit against the surgeon and the medical corporation. Concerned over the workplace incivility charges and the potential for damage to stellar professional reputations and the brand - HR and the executive board retains an external consultant. The consultant utilizes executive coaching, negotiations and conflict resolution in an effort to provide alternatives to litigation. The consultant unmasks unexpected cross-cultural origins of the deadly inappropriate smile. An innovative negotiation method transforms adversaries into allies.
C1 DISSOCIATION IN SERUM: ESTIMATION OF FREE C1q BY ELECTROIMMUNOASSAY (1985)

A two-stage electroimmunoassay was developed for measuring macromolecular C1 (C1qrs) and free C1q. The method was based on Ca2+ dependent fixation of C1qrs to agarose, followed by immune precipitation of dissociated C1s in the presence of EDTA. Free C1q was estimated from the increase in C1qrs resulting from saturation of C1q in the samples with purified C1r-C1s. The assay system was studied under various experimental conditions. Combined analysis by electroimmunoassay and crossed immunoelectrophoresis indicated that part of the free C1q in undiluted normal serum could be attributed to physiological C1 activation. Owing to concentration dependent C1qrs dissociation the proportion of free C1q increased with the dilution of serum. Results obtained with serum and with purified C1qrs were consistent with the formation of an equimolar C1q:C1r-C1s complex. However, the capacity for C1r-C1s binding appeared to be higher in the purified system than in serum. Serum concentrations of free C1q were high in some of the patients with disease conditions characterized by increased C1 activation, such as systemic lupus erythematosus or primary biliary cirrhosis.
Scaling hybrid-integration of silicon photonics in Freescale 130nm to TSMC 40nm-CMOS VLSI drivers for low power communications (2012)

We report new developments on hybrid integration that attaches CMOS driver circuits to silicon photonic (SiPhotonic) devices built in Silicon on Insulator (SOI) technology. This low-parasitic hybrid integration approach enables energy efficient links based on aggressive silicon photonic devices and low power, high speed circuits. The silicon photonic components are fabricated in the 130 nm Cu node of Freescale's SOI-CMOS technology while the CMOS driver circuits are fabricated in 40 nm TSMC ELK technology. The two types of chips are using 20 μm diameter solder bumps. We further present progress on scaling these solder bumps to 10 micron diameter and below as well as developing a wafer scale microsolder process module. Finally, we report progress integrating hybrids that include SOI chips with a partially removed backside. Under full SOI handler removal this bonding geometry is akin to the extreme limit of wafer thinning used in today's vertical chip stacking (3D) approaches.
The TV is Smart and Full of Trackers: Measuring Smart TV Advertising and Tracking (2020)

Abstract In this paper, we present a large-scale measurement study of the smart TV advertising and tracking ecosystem. First, we illuminate the network behavior of smart TVs as used in the wild by analyzing network traffic collected from residential gateways. We find that smart TVs connect to well-known and platform-specific advertising and tracking services (ATSes). Second, we design and implement software tools that systematically explore and collect traffic from the top-1000 apps on two popular smart TV platforms, Roku and Amazon Fire TV. We discover that a subset of apps communicate with a large number of ATSes, and that some ATS organizations only appear on certain platforms, showing a possible segmentation of the smart TV ATS ecosystem across platforms. Third, we evaluate the (in)effectiveness of DNS-based blocklists in preventing smart TVs from accessing ATSes. We highlight that even smart TV-specific blocklists suffer from missed ads and incur functionality breakage. Finally, we examine our Roku and Fire TV datasets for exposure of personally identifiable information (PII) and find that hundreds of apps exfiltrate PII to third parties and platform domains. We also find evidence that some apps send the advertising ID alongside static PII values, effectively eliminating the user’s ability to opt out of ad personalization.
Correlation of the structural and optical properties of luminescent, highly oxidized porous silicon (1994)

The light-emitting properties of rapid thermally oxidized porous Si are studied by both photoluminescence and cathodoluminescence methods. The structure of the material is examined by transmission electron microscopy, while its oxygen content is determined by x-ray microanalysis. These investigations show that crystalline Si nanostructures remain in the heavily oxidized porous material and account for its ∼750 nm red photo- and cathodoluminescence. The work demonstrates that the previously speculated possible importance of either Si-based amorphous phases or the interesting material, siloxene, in this regard is unrealistic. Furthermore, it is shown that the luminescence properties of silicon oxides are of paramount importance in interpreting the many additional (shorter wavelength) emission bands observed.
Obstructive sleep apnea syndrome (OSAS) in acromegaly: does the gender matter? (2022)

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
Testing of Alternative Supporting Materials for Portable Roll-Up Signs Used for Maintenance Work Zones (2014)

Report describing research on portable roll-up transportation signs used to identify short-term work zones, which frequently fail due to gusting wind. The project focused on understanding the effects of wind on the signs, identifying alternative sign frame materials, and developing modified designs for this kind of signage.
Src family protein tyrosine kinase (PTK) modulates the effect of SGK1 and WNK4 on ROMK channels (2009)

WNK4 (with no lysine kinase 4) inhibits ROMK channel activity in the distal nephron by stimulating clathrin-dependent endocytosis, an effect attenuated by SGK1 (serum-glucocorticoids-induced kinase)-mediated phosphorylation. It has been suggested that increased ROMK activity because of SGK1-mediated inhibition of WNK4 plays a role in promoting renal K secretion in response to elevated serum K or high K (HK) intake. In contrast, intravascular volume depletion also increases SGK1 activity but fails to stimulate ROMK channels and K secretion. Because HK intake decreases Src family protein tyrosine kinase (PTK) activity an inhibitor of ROMK channels, it is possible that Src family PTK may modulate the effects of SGK1 on WNK4. Here, we show that c-Src prevents SGK1 from attenuating WNK4's inhibition of ROMK activity. This effect of c-Src was WNK4-dependent because c-Src had no effect on ROMK harboring mutation at the site of c-Src phosphorylation (R1Y337A) in the absence of WNK4. Moreover, expression c-Src diminished the SGK1-mediated increase in serine phosphorylation of WNK4, suggesting that c-Src enhances WNK4-mediated inhibition of ROMK channels by suppressing the SGK1-induced phosphorylation. This notion is also supported by the observation that c-Src was not able to modulate the interaction between SGK1 and WNK4 mutants (WNK4(S1169A) or WNK4(S1169D)) in which an SGK1-phosphorylation site (serine 1169) was mutated by alanine or aspartate. We conclude that c-Src inhibits SGK1-mediated phosphorylation hereby restoring the WNK4-mediated inhibition of ROMK channels thus suppressing K secretion.
Multi-view object pose distribution tracking for pre-grasp planning on mobile robots (2022)

The ability to track the 6D pose distribution of an object when a mobile manipulator robot is still approaching the object can enable the robot to pre-plan grasps that combine base and arm motion. However, tracking a 6D object pose distribution from a distance can be challenging due to the limited view of the robot camera. In this work, we present a framework that fuses observations from external stationary cameras with a moving robot camera and sequentially tracks it in time to enable 6D object pose distribution tracking from a distance. We model the object pose posterior as a multi-modal distribution which results in a better performance against uncertainties introduced by large camera-object distance, occlusions and object geometry. We evaluate the proposed framework on a simulated multi-view dataset using objects from the YCB data set. Results show that our framework enables accurate tracking even when the robot camera has poor visibility of the object.
ChemInform Abstract: Versatile Stereoselective Synthesis of Completely Protected Trifunctional α‐Methylated α‐Amino Acids Starting from Alanine. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A Comprehensive Multi-Modal NDE Data Fusion Approach for Failure Assessment in Aircraft Lap-Joint Mimics (2013)

Multi-modal data fusion techniques are commonly used to enhance decision-making processes. In previous research, a comprehensive structural analysis process was developed for quantizing and evaluating characteristics of defects in aircraft lap-joint mimics using eddy current (EC) nondestructive evaluation (NDE) data collected for structural health monitoring. In this research, a comprehensive multi-modal structural analysis process is presented that includes intra- and inter-modal NDE data fusion based on EC, millimeter wave (MW), and ultrasonic (UT) data obtained from five lap-joint mimic test panels. The process includes defect detection, defect characterization, and finite-element modeling-based simulated fatigue loading for structural analysis. The multi-modal structural analysis process is evaluated using four test panels with corroded patches at different layers of the lap joints and one painted pristine panel used as a reference. The test panels are subjected to two rounds of mechanical loading, preceded by multi-modal NDE data obtained before each round. Different NDE modality combinations are examined for test panel modeling, including: 1) EC, 2) UT, 3) MW, 4) EC and UT, 5) EC and MW, and 6) EC, UT, and MW. Experiments are performed to compare the simulated fatigue loading, based on models determined from the different modality combinations, and the mechanical loading results to find susceptible-to-failure areas in the test panels. Experimental results showed that the EC and UT modality combination yielded a correct vulnerable (crack) location recognition rate of 98.8%, an improvement of 14.7% over any individual modality, demonstrating the potential for multi-modal data fusion for characterizing corrosion and defects.
Iron-based Superconductors (2012)

Iron-Based Superconductors: Discovery and Progress in Materials Hideo Hosono Introduction Small History on Discovery and Progress in Parent Materials Crystal Structure of Parent Materials Parent Material and Superconductivity Unique Characteristics of FeSCs Single Crystal Thin Film Summary and Relevant New Superconductors Synthesis and Physical Properties of the New Potassium Iron Selenide Superconductor R. Hu, E. D. Mun, D. H. Ryan, K. Cho, H. Kim, H. Hodovanets, W. E. Straszheim, M. A. Tanatar, R. Prozorov, W. N. Rowan-Weetaluktuk, J. M. Cadogan, M.M. Altarawneh, C. H. Mielke, V. S. Zapf, S. L. Budko, and P. C. Canfield Introduction Experimental Methods Crystal Growth and Stoichiometry Physical Properties of Single Crystals of K0.80Fe1.76Se2 Summary Angle-Resolved Photoemission Spectroscopy of Iron Pnictides Takafumi Sato, Pierre Richard, Kosuke Nakayama, Takashi Takahashi, and Hong Ding Introduction Experimental Results Concluding Remarks and Summary Quantum Oscillations in Iron Pnictide Superconductors Suchitra E. Sebastian Quantum Oscillations Magnetic Field Dependence Temperature Dependence Iron Pnictide Superconductors Quantum Oscillations in Antiferromagnetic Parent Iron Pnictides Quantum Oscillations in Overdoped Paramagnetic Iron Pnictides Cuprates and Iron Pnictides: Electronic Structure Comparison Conclusion Optical Investigation on Iron-Based Superconductors Nan-LinWang and Zhi-Guo Chen Introduction Introduction About Optical Properties of Solids Optical Studies on the Parent Compounds Multi-Components vs. Extended Drude Model Analysis of Optical Conductivity Electron Correlations in the Fe-Pnictides/Chalcogenides Anisotropic Charge Dynamics Optical Properties of Iron-Based Superconductors Below Tc Antiferromagnetic Spin Fluctuations in the Fe-Based Superconductors Shiliang Li and Pengcheng Dai Introduction Antiferromagnetism in Parent Compounds Magnetic Excitations in the Superconducting State Magnetic Excitations in the Normal State Conclusion Review of NMR Studies on Iron-Based Superconductors Kenji Ishida and Yusuke Nakai Introduction NMR Basics NMR Experimental Results on Iron-Based Superconductors Summary Material Specific Model Hamiltonians and Analysis on the Pairing Mechanism Kazuhiko Kuroki Introduction Model Hamiltonian Construction Spin Fluctuations and Antiferromagnetism Superconductivity Material Dependence Concluding Remarks and Perspectives The Antiferromagnetic Phase of Iron-Based Superconductors: An Itinerant Approach Johannes Knolle and Ilya Eremin Introduction A Primer: Single-Band Hubbard Model Magnetic Order in Ferropnictides SpinWaves in Itinerant Multiorbital Systems Discussion and Conclusion Magnetism in Parent Compounds of Iron-Based Superconductors Jiangping Hu Introduction Experimental Results on the Parent Compounds of Iron-Based Superconductors Theoretical Models Electronic Nematism and the Interplay Between Lattice, Spin and Orbital Discussion
Design and Systems Engineering of AFRL's Demonstration and Sciences Experiment (2005)

This conference features the work of authors from: Georgia Tech’s Space Systems Design Lab, Aerospace Systems Design Lab, School of Aerospace Engineering, Georgia Tech Research Institute; NASA’s Jet Propulsion Laboratory, Marshall Space Flight Center, Goddard Space Flight Center, Langley Research Center; and other aerospace industry and academic institutions