gebhart/patrepeval huggingface dataset:
Circumventricular Organ Apelin Receptor Knockdown Decreases Blood Pressure and Sympathetic Drive Responses in the Spontaneously Hypertensive Rat (2021)

The central site(s) mediating the cardiovascular actions of the apelin-apelin receptor (APJ) system remains a major question. We hypothesized that the sensory circumventricular organs (CVOs), interfacing between the circulation and deeper brain structures, are sites where circulating apelin acts as a signal in the central nervous system to decrease blood pressure (BP). We show that APJ gene (<i>aplnr</i>) expression was elevated in the CVOs of spontaneously hypertensive rats (SHRs) compared to normotensive Wistar Kyoto (WKY) controls, and that there was a greater mean arterial BP (MABP) decrease following microinjection of [Pyr<sup>1</sup>]apelin-13 to the CVOs of SHRs compared to WKY rats. Lentiviral APJ-specific-shRNA (LV-APJ-shRNA) was used to knockdown <i>aplnr</i> expression, both collectively in three CVOs and discretely in individual CVOs, of rats implanted with radiotelemeters to measure arterial pressure. LV-APJ-shRNA-injection decreased <i>aplnr</i> expression in the CVOs and abolished MABP responses to microinjection of [Pyr<sup>1</sup>]apelin-13. Chronic knockdown of <i>aplnr</i> in any of the CVOs, collectively or individually, did not affect basal MABP in SHR or WKY rats. Moreover, knockdown of <i>aplnr</i> in any of the CVOs individually did not affect the depressor response to systemic [Pyr<sup>1</sup>]apelin-13. By contrast, multiple knockdown of <i>aplnr</i> in the three CVOs reduced acute cardiovascular responses to peripheral [Pyr<sup>1</sup>]apelin-13 administration in SHR but not WKY rats. These results suggest that endogenous APJ activity in the CVOs has no effect on basal BP but that functional APJ in the CVOs is required for an intact cardiovascular response to peripherally administered apelin in the SHR.
Stereoselective syntheses of 3‐mercaptoproline derivatives protected for solid phase peptide synthesis (1996)

The incorporation of cis- and trans-3-mercaptoproline (3-MPc and 3-MPt) into analogs of biologically active peptides has been shown to be an effective means for reducing the conformational mobility of the peptide backbone. We report herein a novel stereoselective synthetic route to L-1 and L-2, derivatives of 3-MPt and 3-MPc suitably protected for solid phase peptide synthesis. The optically active starting material was the previously reported cis-3-hydroxyprolinol derivative L-3. Oxidation of the C1 alcohol to the carboxylic acid, formation of the methyl ester and deprotection of the C3 alcohol yielded L-6 in an overall yield of 68%. Reaction of the secondary alcohol with thiolacetic acid under Mitsunobu conditions gave the thiolacetate L-7 in 77% yield with clean inversion of configuration. Conversion of L-7 to L-1 was accomplished in a one-pot sequence consisting of three steps: hydrolysis of the thiolacetate, formation of the thioether and hydrolysis of the methyl ester. The overall yield of L-1 from L-3 was 38%. Synthesis of L-2 required an epimerization of L-6, which was accomplished using a standard Mitsunobu inversion to give the trans-3-hydroxyproline derivative L-8. Transformation of L-8 to L-2 followed that described for overall yield of L-2 from L-3 was 18%. The availability of pure enantiomers of 3-MPt and 3-MPc protected for SPPS will greatly facilitate their use as conformational constraints for studying peptide-receptor interactions.
Enabling "hinge" model by slow dynamics in variable DGD based PMD emulator (2005)

By slow polarization coupling and re-organizing applied DGD to each section of variable DGD based PMD emulator, we realize slow dynamics with negligible distortion of generated PMD statistics to enable "hinge" model for system evaluation. (2 pages)
Spinal Cord Stimulation Electrode Design: A Prospective, Randomized, Controlled Trial Comparing Percutaneous with Laminectomy Electrodes: Part II–Clinical Outcomes (2005)

Laminectomy electrode placement, although more invasive than percutaneous placement, yields significantly better clinical results in patients with failed back surgery syndrome at mean 1.9 years follow-up. In our small sample, however, the statistical significance of this advantage disappeared at mean 2.9 years follow-up.
Dual-mode patch antenna switched by PIN diode (2004)

Since various wireless communication services are available, it is required to make a mobile terminal which can handle several such services. Therefore, it is necessary to design a multimode, multifrequency antenna which has different polarization and radiation patterns at each band; the switching of the resonant modes should be controlled electronically. We propose a dual-mode patch antenna where a PIN diode switch is used to change the resonant mode of the antenna. The basic structure of the antenna is a planar inverted F-shape antenna (PIFA) with a PIN diode at the open terminal of the patch. The PIN diode is switched by the DC bias which is provided at the RF feed. When the PIN diode is biased forward (ON), the antenna operates as a loop antenna, while when the PIN diode is biased backward (OFF), the antenna works as a PIFA. The characteristics of the antenna, such as resonant frequency, radiation pattern, and radiation efficiency are investigated experimentally and numerically. The antenna's resonant frequency and radiation characteristics can be changed by using the PIN diode switch, and the radiation efficiency degrades when forward-bias is added to the diode. The degradation of the radiation efficiency is mainly caused by high forward-bias resistance, which indicates that it is necessary to use a PIN diode with low forward-bias resistance.
bFGF induces S1P1 receptor expression and functionality in human pulmonary artery smooth muscle cells (2008)

Sphingosine-1-phosphate (S1P), acting through five closely related G-protein coupled receptors termed S1P1-5, has recently emerged as a possible regulator of smooth muscle cell (SMC) physiology with the potential to induce contraction, proliferation and stress fiber formation. In the present study, real-time quantitative PCR was used to determine the expression patterns of S1P receptor subtypes in human primary pulmonary artery smooth muscle cells (PASMC). We report here that subconfluent PASMC express predominantly S1P2 and S1P3 receptors and we show that S1P1 receptor mRNA levels are significantly up-regulated following basic fibroblast growth factor (bFGF) treatment. As a consequence, increased responsiveness, as measured by impedance and ERK1/2 phosphorylation, was observed upon stimulation with a specific S1P1 receptor agonist SEW2871. We therefore demonstrate, for the first time, that a growth factor that was previously shown to be involved in physiological and pathological changes of SMC function induced S1P1 receptor expression and we propose that S1P1 receptor up-regulation could contribute to vascular remodeling.
Soil indigenous microbiome and plant genotypes cooperatively modify soybean rhizosphere microbiome assembly (2019)

This comprehensive comparison of the soybean microbiome between soil types and genotypes expands our understanding of rhizosphere microbe assembly in general and provides foundational information for soybean as a legume crop for this assembly process. The cooperative modulating role of the soil type and host genotype emphasizes the importance of integrated consideration of soil condition and plant genetic variability for future development and application of synthetic microbiomes. Additionally, the detection of the tuning role by soybean genotype in rhizosphere microbiome assembly provides a promising way for future breeding programs to integrate host traits participating in beneficial microbiota assembly.
Preferred Conformation of C-Glycosides. 13. A Comparison of the Conformational Behavior of Several C-, N-, and O-Furanosides (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreferred Conformation of C-Glycosides. 13. A Comparison of the Conformational Behavior of Several C-, N-, and O-FuranosidesDaniel J. O'Leary and Yoshito KishiCite this: J. Org. Chem. 1994, 59, 22, 6629–6636Publication Date (Print):November 1, 1994Publication History Published online1 May 2002Published inissue 1 November 1994https://pubs.acs.org/doi/10.1021/jo00101a022https://doi.org/10.1021/jo00101a022research-articleACS PublicationsRequest reuse permissionsArticle Views442Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Ultrafast molecular frame electronic coherences from lab frame scattering anisotropies (2020)

Abstract Electronic coherences in molecules are ultrafast charge oscillations on the molecular frame (MF) and their direct observation and separation from electronic population dynamics is challenging. Here we present a valence shell lab frame (LF) scattering method suited to probing electronic coherences in isolated systems. MF electronic coherences lead to LF electronic anisotropies observable by ultrafast angle-resolved scattering. Moment analysis of the LF anisotropy completely separates electronic coherences from population dynamics, demonstrated in excited state NH 3 using ultrafast time-energy-angle-resolved photoelectron spectroscopy. This general approach applies equally to attosecond/femtosecond electronic coherences in isolated systems.
A result on the existence of quadratic Lyapunov functions for state-dependent switched systems with uncertainty (2010)

Recent results on quadratic stability of state-dependent switched linear systems are reviewed and applied to the problem of state-dependent switching with parameter uncertainty. Several examples are provided to illustrate the method, both as a means of determining stability of such systems, and also as a tool for designing stable switched systems in the presence of uncertainty.
Large area holograpic surface relief micropatterns by embossing of thixotropic nanocomposite layers on plastic substrates (2000)

A new embossing technique for the fabrication of holographic surface relief micropatterns on plastic substrates has been developed.For state-of-the art embossing techniques with UV curable polymers or ormocers, the curing step has to be performed under the stamper or embossing roll.This leads to rather long processing times and restrictions to fast curing materials like methacrylates.This general drawback could be overcome by embossing of nanocomposite layers with thixotropic behaviour.In these layers, the viscosity decreases with increasing shear rate (imprinting step) and decreases again with degreasing shear rate (removing of the stamper or embossing roll).This allows to perform the UV curing after the removal of the embossing tool.This new principle for micropatterning is demonstrated with organic-inorganic nanocomposite (Nanomer) layers, prepared from methacrylsilane (MPTS), fluorosilane and ZrO 2 nanoparticles in MPTS : ZrO 2 ratios between 10:1 and 1:2.Wet films of 15 m in thickness have been prepared by doctor blade coating.After drying at 80C for 3 minutes, holographic and CD-ROM like pitch patterns have been embossed using an embossing roll of 24 cm in diameter and 35 cm in width with a patterned Ni foil using embossing speeds between 1 m/min and 30 m/min and a final UV curing with about 100 W/cm 2 for 30 s.By this method, picture holographic patterns with structural depths of up to 350 nm have been prepared on areas of 180 mm x 300 mm and CD-ROM-like pitch patterns with depths of 140 nm have been generated on areas with 120 mm diameter.The rheology of the dried gel layers, the refractive index and the UV-curing behaviour of the Nanomer material are discussed as a function of the size and concentration of the ZrO 2 nanoparticles.This new technique offers very interesting prospects to cut down the processing time of CD-ROM-patterns, prepared by injection moulding by more than 1 order of magnitude.
Faculty Opinions recommendation of Modulation of Cav1.3 Ca2+ channel gating by Rab3 interacting molecule. (2010)

Neurotransmitter release and spontaneous action potentials during cochlear inner hair cell (IHC) development depend on the activity of Ca(v)1.3 voltage-gated L-type Ca(2+) channels. Their voltage- and Ca(2+)-dependent inactivation kinetics are slower than in other tissues but the underlying molecular mechanisms are not yet understood. We found that Rab3-interacting molecule-2alpha (RIM2alpha) mRNA is expressed in immature cochlear IHCs and the protein co-localizes with Ca(v)1.3 in the same presynaptic compartment of IHCs. Expression of RIM proteins in tsA-201 cells revealed binding to the beta-subunit of the channel complex and RIM-induced slowing of both Ca(2+)- and voltage-dependent inactivation of Ca(v)1.3 channels. By inhibiting inactivation, RIM induced a non-inactivating current component typical for IHC Ca(v)1.3 currents which should allow these channels to carry a substantial window current during prolonged depolarizations. These data suggest that RIM2 contributes to the stabilization of Ca(v)1.3 gating kinetics in immature IHCs. PMID: 20363327 Funding information This work was supported by: Austrian Science Fund FWF, Austria Grant ID: W 1101 Austrian Science Fund FWF, Austria Grant ID: P 20670 Austrian Science Fund FWF, Austria Grant ID: P 17807
Rose bengal and nonpolar derivatives (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRose bengal and nonpolar derivativesJoseph J. M. Lamberts and D. C. NeckersCite this: J. Am. Chem. Soc. 1983, 105, 25, 7465–7467Publication Date (Print):November 1, 1983Publication History Published online1 May 2002Published inissue 1 November 1983https://pubs.acs.org/doi/10.1021/ja00363a056https://doi.org/10.1021/ja00363a056research-articleACS PublicationsRequest reuse permissionsArticle Views599Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Cooling Efficiency Concept — A Tool for Fast Thermal Analysis of PCBs (1993)

Thermal analyses of printed circuit boards (PCBs) based on the finite element or finite difference methods are frequently used in the electronics industry, the major reason for this being the geometrical complexity of the thermal problems. Correctly used and with access to all relevant data, these methods are very accurate. In the early stages of the PCB design process, it is often necessary to make temperature estimations based on data which are very uncertain and sometimes mere guesswork. Any temperature prediction based on such assumptions will, regardless of the method used, always be of a preliminary nature. A fast and approximate method can then offer advantages over a complex but accurate method. The cooling efficiency for a PCB is defined as the heat dissipation for the PCB over the heat dissipation for a flat smooth isothermal plate of the same size and with a temperature which equals the maximum temperature of the PCB. This definition makes it possible to derive the maximum temperature on a PCB from the well‐defined isothermal case. The cooling efficiency for a particular PCB can be calculated or measured. The experience of the author is that the values for most multilayer PCBs are in the range 50–85%. For PCBs which have a few concentrated heat sources, the cooling efficiency could be considerably lower. For PCBs with any form of surface extension, the cooling efficiency could be higher. The cooling efficiency concept is particularly useful as a fast front‐end thermal analysis tool. The concept can also be used in conjunction with thermal specifications of PCBs and at the PCB enclosure level.
Incremental Delta Sigma Modulation with Dynamic Weighted Integration (2018)

This paper presents a technique to reduce the required number of cycles to reach a given quantization resolution of conversion performed by incremental ΔΣ ADCs. Thanks to a specifically designed dynamic weighting of the modulator's coefficients combined with a dedicated digital filter, the OverSampling Ratio (i.e., OSR) can be reduced compared to conventional structures thanks to a more efficient quantization noise shaping. This Dynamic Weighted Integration (DWI) technique is first motivated in the context of a first order modulator supported with a mathematical proof. In the second part, the proposed technique is extended to the specific case of a complex fourth order modulator with four different examples of topology regarding the position of the dynamic weighting.
An investigation of the hydrophobic property stability of grafted polymeric coatings on a cellulose material surface (2016)

Modification of cotton fabric surface by random or block copolymers of glycidyl methacrylate and lauryl methacrylate is studied. It is shown that a cotton fabric surface modified in such a way takes on superhydrophobic properties and differs in stability under long-term contact with aqueous media.
User-Generated Content (2008)

Pervasive user-generated content takes the traditional idea of user-generated content and expands it off the desktop into our everyday world. The six articles in this special issue give innovative examples of gathering and using such content.
AlP/GaP quantum wells for implementing intersubband devices in the 30-60 µm wavelength region. (2009)

International audience
Vacancy-modulated conductive oxide resistive RAM (VMCO-RRAM): An area-scalable switching current, self-compliant, highly nonlinear and wide on/off-window resistive switching cell (2013)

We report a novel self-compliant and self-rectifying resistive switching memory cell, with area-scalable switching currents, featuring a set current density of ~5nA/nm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> (<;9uA for a 40nm-size cell), high on-state half-bias nonlinearity of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and low reset current density of <;0.6nA/nm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> (<;1uA@40nm size). The cell can be operated at below ±4V/10ns, with a large on/off window of >10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and retention extrapolates to 10yr at 101°C. The switching stack is fully based on ALD processes, using common high-k dielectrics and has a thickness of <;10nm, meeting the 3D Vertical RRAM requirements. Moreover, we point out the nonlinearity-low-current operation interdependence and discuss the scaling potential of the areal switching RRAM for reliable sub-μA current operation in the 10nm-cell size realm.
Repopulation of primary renal cells for whole organ engineering (2012)

Agcaoili, Sigrid M. MD; Aboushwareb, Tamer MD, PhD; Jackson, John D. PhD; Yoo, James J. MD, PhD; Atala, Anthony MD, FACS Author Information
Path-based shadow removal (2005)

It has been shown that by thresholding the image gradient at the location of shadow edges and then reintegrating, shadow-free images can be obtained. Unfortunately, the current methods are computationally expensive and also create artifacts in the reintegrated image. Our proposed method uses non-intersecting random paths (also called Hamiltonian paths) to allow for fast 1D reintegration. Because the artifacts are due to missing gradient information, we further improve the results by inpainting the detected shadow edges as to prevent the occurrence of unwanted artifacts.
Bayesian Optimization for Online Management in Dynamic Mobile Edge Computing (2022)

Recent years have witnessed the emergence of mobile edge computing (MEC), on the premise of a cost-effective enhancement in the computational ability of hardware-constrained wireless devices (WDs) comprising the Internet of Things (IoT). In a general multi-server multi-user MEC system, each WD has a computational task to execute and has to select binary (off)loading decisions, along with the analog-amplitude resource allocation variables in an online manner, with the goal of minimizing the overall energy-delay cost (EDC) with dynamic system states. While past works typically rely on the explicit expression of the EDC function, the present contribution considers a practical setting, where in lieu of system state information, the EDC function is not available in analytical form, and instead only the function values at queried points are revealed. Towards tackling such a challenging online combinatorial problem with only bandit information, novel Bayesian optimization (BO) based approaches are put forth by leveraging the multi-armed bandit (MAB) framework. Per time slot, the discrete offloading decisions are first obtained via the MAB method, and the analog resource allocation variables are subsequently optimized using the BO selection rule. By exploiting both temporal and contextual information, two novel BO approaches, termed time-varying BO and contextual time-varying BO, are developed. Numerical tests validate the merits of the proposed BO approaches compared with contemporary benchmarks under different MEC network sizes.
Improving disk cache hit-ratios through cache partitioning (1992)

An adaptive algorithm for managing fully associative cache memories shared by several identifiable processes is presented. The on-line algorithm extends an earlier model due to H.S. Stone et al. (1989) and partitions the cache storage in disjoint blocks whose sizes are determined by the locality of the processes accessing the cache. Simulation results of traces for 32-MB disk caches show a relative improvement in the overall and read hit-ratios in the range of 1% to 2% over those generated by a conventional least recently used replacement algorithm. The analysis of a queuing network model shows that such an increase in hit-ratio in a system with a heavy throughput of I/O requests can provide a significant decrease in disk response time.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Mixture Regression Estimation (1998)

validation are a single “best” models. In conta:st, validated mixtures binations of all We empirically mixtures (both sion estimation.