gebhart/patrepeval huggingface dataset:
Iminosugar idoBR1 Isolated from Cucumber Cucumis sativus Reduces Inflammatory Activity (2020)

Cucumbers have been anecdotally claimed to have anti-inflammatory activity for a long time, but the active principle was not identified. idoBR1, (2<i>R</i>,3<i>R</i>,4<i>R</i>,5<i>S</i>)-3,4,5-trihydroxypiperidine-2-carboxylic acid, is an iminosugar amino acid isolated from fruits of certain cucumbers, <i>Cucumis sativus</i> (Cucurbitaceae). It has no chromophore and analytically behaves like an amino acid making detection and identification difficult. It has anti-inflammatory activity reducing lipopolysaccharide (LPS)-induced tumor necrosis factor alpha (TNF-α) in THP-1 cells and <i>ex vivo</i> human blood. It showed selective inhibition of human α-l-iduronidase and sialidases from both bacteria (<i>Tannerella forsythia</i>) and human THP-1 cells. idoBR1 and cucumber extract reduced the binding of hyaluronic acid (HA) to CD44 in LPS-stimulated THP-1 cells and may function as an anti-inflammatory agent by inhibiting induced sialidase involved in the production of functionally active HA adhesive CD44. Similar to the related iminosugars, idoBR1 is excreted unchanged in urine following consumption. Its importance in the diet should be further evaluated.
ChemInform Abstract: Applications of 17O NMR Spectroscopy to Natural Products Chemistry (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Limitations imposed by Fabry-Perot sliding filters on soliton WDM transmission (2005)

Summary form only given. In a soliton transmission line with Fabry-Perot etalons as sliding-frequency guiding filters, the channel spacing is determined by the separation between the frequencies at the peaks of the filter transmission function. By changing the free spectral range of the filter one may bring the wavelength-division multiplexing (WDM) channels closer. On the other hand, the filter characteristics cannot be changed arbitrarily because at some parameter values the soliton cease to propagate stably. We analyze how closely one can bring WDM channels with Fabry Perot etalons while maintaining stable soliton propagation.
Alkenylsilane Effects on Organotitanium-Catalyzed Ethylene Polymerization. Toward Simultaneous Polyolefin Branch and Functional Group Introduction (2006)

The comonomer 5-hexenylsilane is introduced into organotitanium-mediated ethylene polymerizations to produce silane-terminated ethylene/5-hexenylsilane copolymers. The resulting polymers were characterized by 1H and 13C NMR, GPC, and DSC. High activities (up to 107 g polymer/(mol Ti.atm ethylene.h)) and narrow polydispersities are observed in the polymerization/chain transfer process. Ethylene/5-hexenylsilane copolymer molecular weights are found to be inversely proportional to 5-hexenylsilane concentration, supporting a silanolytic chain transfer mechanism. Control experiments indicate that chain transfer mechanism by 5-hexenylsilane is significantly more efficient than that of n-hexylsilane for organotitanium-mediated ethylene polymerization. The present study represents the first case in which a functionalized comonomer is efficiently used to effect both propagation and chain transfer chemistry during olefin polymerization.
ChemInform Abstract: Reaction of 4‐Cyano‐1,3‐dihydroxy‐5,6,7,8‐tetrahydroisoquinolines with Vilsmeier Reagent: Structure and Mechanism of Formation of (2,7) Naphthyridines. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Fabrication of tissue‐engineered cell sheets by automated cell culture equipment (2019)

Most cells for regenerative medicine are currently cultured manually. In order to promote the widespread use of regenerative medicine, it will be necessary to develop automated culture techniques so that cells can be produced in greater quantities at lower cost and with more stable quality. In the field of regenerative medicine technology, cell sheet therapy is an effective tissue engineering technique whereby cells can be grafted by attaching them to a target site. We have developed automated cell culture equipment to promote the use of this cell sheet regenerative treatment. This equipment features a fully closed culture vessel and circuit system that avoids contamination with bacteria and the like from the external environment, and it was designed to allow 10 cell sheets to be simultaneously cultured in parallel. We used this equipment to fabricate 50 sheets of human oral mucosal epithelial cells in five automated culture tests in this trial. By analyzing these sheets, we confirmed that 49 of the 50 sheets satisfied the quality standards of clinical research. To compare the characteristics of automatically fabricated cell sheets with those of manually fabricated cell sheets, we performed histological analyses using immunostaining and transmission electron microscopy. The results confirmed that cell sheets fabricated with the automated cell culture are differentiated in the same way as cultures fabricated manually.
The Power-Saving Mechanism With Periodic Traffic Indications in the IEEE 802.16e/m (2009)

In IEEE Standards 802.16e (air interface standard for MWiMAX) and 802.16m (evolution of MWiMAX for IMT-Advanced), power saving is one of the important issues for battery-powered mobile stations (MSs) due to mobility. According to the IEEE 802.16e standard, when an MS switches from awake mode to sleep mode, the MS is required to send a sleep request (MOB-SLP-REQ) message and to receive a sleep response (MOB-SLP-RSP) message. In this paper, we propose a new sleep mode scheme called the <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">power-saving mechanism with periodic traffic indications</i> , where the MOB-SLP-REQ/RSP messages are omitted, and a traffic indication (TRF-IND) message is <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">periodically</i> sent at the beginning of every constant TRF-IND interval. The merits of the proposed scheme are simple implementation, reduction of energy consumption, and saving of the resource compared with the sleep mode in the IEEE 802.16e standard. The proposed scheme in this paper is well aligned with the design policy of sleep mode in discussion at IEEE 802.16m in the sense that it tries to minimize the state transition overhead between the awake and sleep modes, and hence, it can reduce the delay for state transition and enhance the power-saving efficiency. We investigate the performance of the proposed scheme in two ways: simulation and analytical methods. Using the performance evaluation, we find the optimal TRF-IND interval, which minimizes the average power consumption of the MS while satisfying the quality of service (QoS) on the mean delay. Numerical results show that the proposed scheme has 20%-50% reduction of the energy compared with the power-saving class (PSC) of type I, which is one of three operations for sleep mode in IEEE 802.16e.
Prophylactic antibiotics or G(M)-CSF for the prevention of infections and improvement of survival in cancer patients receiving myelotoxic chemotherapy (2015)

As we only found two small trials with 195 patients altogether, no conclusion for clinical practice is possible. More trials are necessary to assess the benefits and harms of G(M)-CSF compared to antibiotics for infection prevention in cancer patients receiving chemotherapy.
Large-Scale Learning to Rank Using Boosted Decision Trees (2011)

The web search ranking task has become increasingly important because of the rapid growth of the internet. With the growth of the web and the number of web search users, the amount of available training data for learning web ranking models has also increased. We investigate the problem of learning to rank on a cluster using web search data composed of 140,000 queries and approximately 14 million URLs. For datasets much larger than this, distributed computing will become essential, because of both speed and memory constraints. We compare a baseline algorithm that has been carefully engineered to allow training on the full dataset using a single machine, in order to evaluate the loss or gain incurred by the distributed algorithms we consider. The underlying algorithm we use is a boosted tree ranking algorithm called LambdaMART, where a split at a given vertex in each decision tree is determined by the split criterion for a particular feature. Our contributions are twofold. First, we implement a method for improving the speed of training when the training data fits in main memory on a single machine by distributing the vertex split computations of the decision trees. The model produced is equivalent to the model produced from centralized training, but achieves faster training times. Second, we develop a training method for the case where the training data size exceeds the main memory of a single machine. Our second approach easily scales to far larger datasets, that is, billions of examples, and is based on data distribution.
Xylanase Impact beyond Performance: Effects on Gut Structure, Faecal Volatile Fatty Acid Content and Ammonia Emissions in Weaned Piglets Fed Diets Containing Fibrous Ingredients (2022)

The addition of xylanase to piglet diets is known to improve performance and nutrient digestibility. The present study aimed to assess the impact of new xylanase on the growth performance, nutrient digestibility, and gut function of weaned piglets. A total of 144 pigs, weaned at 28 days (7.48 kg initial body weight, IBW), were assigned to 36 pens and 9 pens per treatment. Dietary treatments were a basal complex control diet, and the basal diet supplemented with 45,000, 90,000 and 135,000 U/kg xylanase. Performance was measured at days 0, 14 and 35. At day 35, samples were collected for assessment of intestinal histology, and volatile fatty acid and ammonia concentrations. After two weeks post-weaning, additional 12 piglets (11.34 kg IBW) were placed in metabolic crates for assessment of apparent total tract nutrient digestibility using a dietary marker. The addition of xylanase at 90,000 and 135,000 U/kg significantly improved average daily gain (333.6 g/day control, 364.86 g/day, 90,000 U/kg, 405.89 g/day, 135,000 U/kg, p < 0.05), G:F (0.557 control, 0.612 90,000 U/kg, 0.692 135,000 U/kg, p < 0.05), and reduced diarrhoea. This was driven improved nutrient digestibility and villus height in the jejunum (372.87 µm control, 432.53 µm 45,000 U/kg, 465.80 µm 90,000 U/kg, 491.28 µm 135,000 U/kg, p < 0.05). Xylanase supplementation also linearly increased faecal butyrate levels and had a quadratic relationship with propionate concentrations. 135,000 U/kg xylanase also reduced ammonia emissions. In conclusion, dietary supplementation with xylanase improved growth performance and feed efficiency in weaning piglets, likely driven by improvements to gut structure and function.
Computational Predictions of Stable 2D Arrays of Bidisperse Particles (2005)

We study computationally the stability of various 2D arrays of bidisperse mixtures of stabilized nanoparticles through a melting simulation employing the Metropolis algorithm for determining surface diffusion. In our previous work [Langmuir 2004, 20, 9408], we studied computationally the stability of bidispersed monolayers of thiol-stabilized gold nanoparticles with a size ratio (sigma) of 0.375. We found that interparticle forces were essential to stabilize the LS (the two-dimensional NaCl analogue) lattice at the experimentally determined surface coverage. In this paper, we extend our study to determine the conditions necessary to form stable LS(2), LS(4), and LS(6) lattices, which have yet to be observed. Using a simple design rule that involves matching the distances between either large-large particles and large-small particles or large-small particles and small-small particles to correspond to the respective potential minima leads to predictions for size ratios that will form each desired lattice, given other parameters characterizing the systems' physical properties. We predict and verify computationally LS(2), LS(4), and LS(6) lattices at relatively low surface coverages. Additional simulations show that the LS, LS(2), and LS(6) lattices are indeed stable structures at their predicted surface coverage, whereas the LS(4) lattice is a metastable structure; however, a modest increase in the surface coverage of the LS(4) lattice converts it to a stable rather than long-lived metastable structure. This study may be used as a guide for experimentalists in their search for these novel structures.
1444: Efficacy of Intravesical Ropivacaine Injection on Urinary Symptoms following Ureteral Stenting: A Randomized, Controlled Study (2007)

You have accessJournal of UrologyModerated Poster 44, Tuesday, May 22, 2007, 1:00 - 3:00 pm1 Apr 20071444: Efficacy of Intravesical Ropivacaine Injection on Urinary Symptoms following Ureteral Stenting: A Randomized, Controlled Study George E. Haleblian, Roger L. Sur, Sean A. Pierre, Mamie R. Robinson, David M. Albala, and Glenn M. Preminger George E. HaleblianGeorge E. Haleblian More articles by this author , Roger L. SurRoger L. Sur More articles by this author , Sean A. PierreSean A. Pierre More articles by this author , Mamie R. RobinsonMamie R. Robinson More articles by this author , David M. AlbalaDavid M. Albala More articles by this author , and Glenn M. PremingerGlenn M. Preminger More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)31645-8AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "1444: Efficacy of Intravesical Ropivacaine Injection on Urinary Symptoms following Ureteral Stenting: A Randomized, Controlled Study." The Journal of Urology, 177(4S), p. 477 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 177Issue 4SApril 2007Page: 477 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information George E. Haleblian More articles by this author Roger L. Sur More articles by this author Sean A. Pierre More articles by this author Mamie R. Robinson More articles by this author David M. Albala More articles by this author Glenn M. Preminger More articles by this author Expand All Advertisement PDF DownloadLoading ...
Ring-Opening Metathesis Polymerization of (+)- and (.+-.)-endo,exo-5,6-Dimethylbicyclo[2.2.1]hept-2-ene by Mo(CH-t-Bu)(N-2,6-C6H3-i-Pr2)(OR)2 (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRing-Opening Metathesis Polymerization of (+)- and (.+-.)-endo,exo-5,6-Dimethylbicyclo[2.2.1]hept-2-ene by Mo(CH-t-Bu)(N-2,6-C6H3-i-Pr2)(OR)2Tadahiro Sunaga, Kenneth J. Ivin, Gretchen E. Hofmeister, John H. Oskam, and Richard R. SchrockCite this: Macromolecules 1994, 27, 15, 4043–4050Publication Date (Print):July 1, 1994Publication History Published online1 May 2002Published inissue 1 July 1994https://pubs.acs.org/doi/10.1021/ma00093a003https://doi.org/10.1021/ma00093a003research-articleACS PublicationsRequest reuse permissionsArticle Views299Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Oligopeptides as catalysts for asymmetric epoxidation (2005)

Oligopeptides are versatile catalysts for the enantioselective epoxidation of electron deficient alkenes, (e.g. alpha,beta-unsaturated ketones) with alkaline hydrogen peroxide. This review describes optimisation of the catalyst, substrate range, synthetic applications of the products and rationalisation of the stereoselectivity by an active site model.
A candidate approach for optical in-network computation (2016)

Issues in developing support for in-network computation on optical signals are presented. Key challenges and concerns with past attempts are addressed, including difficulties supporting high-level computational models. A candidate approach using frequency mixing of M-PSK signals for both computation and transmission is presented.
Metyrapone Treatment in Endogenous Cushing’s Syndrome: Results at Week 12 From PROMPT, a Prospective International Multicenter, Open-Label, Phase III/IV Study (2021)

Abstract Background: Metyrapone is a steroidogenesis inhibitor approved in Europe for the treatment of endogenous Cushing’s syndrome (CS) based on observational retrospective studies published over more than 50 years. We present data from the first prospective study designed to confirm metyrapone efficacy and good tolerance in patients with CS. Methods: This single arm, open-label, multicenter, international trial enrolled 50 patients with CS who had three baseline 24 hours urine free cortisol (UFC) values at least 50% above the upper limit of normal (ULN=165 nmol/24h). Metyrapone was titrated over 12 weeks (W12) to achieve normal urine (mean of 3 values, mUFC) and serum cortisol levels. Patients whose mUFC did not exceed 2-fold the ULN could enter a 6-month extension period. The primary efficacy endpoint was the proportion of patients with mUFC ≤ ULN at W12 assessed in a central laboratory using LC-MS/MS. The most important secondary endpoint was mUFC decrease of ≥ 50% at W12. Results: At baseline: mean age was 47 years, median mUFC (range) was 570 (291 - 8476) nmol/24h (3.5 x ULN). Hypercortisolism was in 96% of patients either moderate (mUFC ≥ 2xULN; &amp;lt; 5x ULN) in 63% or severe (≥5 x ULN) in 33%. Hypertension (69%) and diabetes mellitus (47%) were the most common comorbidities. At W12: 47% (23/ 49) met primary endpoint. Another 40% (19 / 49) had mUFC ≤ 2xULN. Median percentage decrease in mUFC from baseline to W12 was -74%. Secondary endpoint was met by 80% of patients who had a mUFC decrease of 50%. Final median metyrapone dose was 1500 (250; 5500) mg/day. Physical signs and symptoms were normalized or improved in 66% of patients. Circulating cholesterol, HbA1C and fasting glucose and insulin improved with median decrease of 12%, 3%, 5% and 9% respectively and median systolic and diastolic blood pressure also decreased by 4 and 5mmHg respectively. Among patients with antihypertensive treatments, 10 (31%) had a decrease in number of drugs and 5 (16%) had an increase in number of drugs during the study. Median ACTH increased by 11 % from baseline. Twenty six (52%) patients experienced mild to moderate study drug related adverse events (AEs). One patient discontinued before W12 because of an unrelated SAE on day 2 (pneumonia with septic shock). The most common AEs were nausea (24%), decreased appetite (18%), fatigue (14%), headache (10%), peripheral edema (6.0%), hypokalemia (6.0%) and hypertension (6.0%). Reversible adrenal insufficiency occurred in 6 (12%) patients. Few patients 14% (7/50) experienced at least one AE that led to a dose interruption or dose adjustment. Cushing Quality of Life Questionnaire increased of 10 points from baseline which is close to minimal clinically important difference = 10.1. Conclusions: This prospective study in patients with CS confirms that metyrapone effectively lowers UFC levels with a tolerability profile similar to the previously reported safety profile and improves QoL, at Week 12.
PROFILING OF SELECTED MICRONUTRIENTS AND HEAVY METAL ELEMENTS IN OCIMUM SANCTUM BY ATOMIC ABSORPTION SPECTROSCOPY (2018)

Background: Ocimum sanctum commonly called as Tulsi, sacred to Hindus and possess various biological activities. Medicinal plant raw materials will be checked for the presence of heavy metals and trace elements concentration. Beyond permissible level is mater of great concern to public safety all over the world. Usually accumulation of essential elements may also lead to toxic at high levels. Aim: The present study emphasises on the levels of some selected essential micro nutrients and heavy metal concentrations in Ocimum sanctum. Method: Profiling of trace elements was done by Atomic Absorption Spectroscopy. Zinc, Copper, Manganese, Chromium, iron, lead and cadmium element levels were estimated. Results: All the selected elements were within the permissible levels of World Health Organization. Lead and cadmium were not found in both varieties Conclusion: From the results it is concluded that intake of Ocimum sanctum as in the raw form will be safe as there is no accumulation of micronutrients and toxic elements
Functionalization of tactile sensation for robot based on haptograph and model decomposition (2011)

Abstract In the real world, robots should be able to recognize the environment in order to be of help to humans. A video camera and a laser range finder are devices that can help robots recognize the environment. However, these devices cannot obtain tactile information from environments. Future human‐assisting robots should have the ability to recognize haptic signals, and a disturbance observer can possibly be used to provide the robot with this ability. In this study, a disturbance observer is employed in a mobile robot to functionalize the tactile sensation. This paper proposes a method that involves the use of the haptograph and modal decomposition for the haptic recognition of road environments. The haptograph presents a graphic view of the tactile information. It is possible to classify road conditions intuitively. The robot controller is designed by considering the decoupled modal coordinate system, which consists of translational and rotational modes. Modal decomposition is performed by using a quarry matrix. Once the robot is provided with the ability to recognize tactile sensations, its usefulness to humans will increase. © 2011 Wiley Periodicals, Inc. Electr Eng Jpn, 177(2): 49–57, 2011; Published online in Wiley Online Library ( wileyonlinelibrary.com ). DOI 10.1002/eej.21169
Optical frequency comb spectroscopy at 3-5.4 {\mu}m with a doubly resonant optical parametric oscillator (2016)

We present a versatile mid-infrared frequency comb spectroscopy system based on a doubly resonant optical parametric oscillator tunable in the 3-5.4 {\mu}m range and two detection methods, a Fourier transform spectrometer (FTS) and a Vernier spectrometer. Using the FTS with a multipass cell we measure high-precision broadband absorption spectra of CH$_4$ and NO at ~3.3 {\mu}m and ~5.2 {\mu}m, respectively, and of atmospheric species (CH$_4$, CO, CO$_2$ and H$_2$O) in air in the signal and idler wavelength range. The figure of merit of the system is on the order of 10$^{-8}$ cm$^{-1}$ Hz$^{-1/2}$ per spectral element, and multiline fitting yields minimum detectable concentrations of 10-20 ppb Hz$^{-1/2}$ for CH$_4$, NO and CO. For the first time in the mid-infrared, we perform continuous-filtering Vernier spectroscopy using a low finesse enhancement cavity, a grating and a single detector, and measure the absorption spectrum of CH$_4$ and H$_2$O in ambient air at ~3.3 {\mu}m.