gebhart/patrepeval huggingface dataset:
Renal cell carcinoma: basic biology and clinical behavior. (1996)

The incidence of renal cell carcinoma (RCC) has gradually increased, and approximately 40% of all patients diagnosed with this disease will die of it. With the increasing availability of ultrasonography and computed tomography (CT) scanning, incidental renal tumors are more frequently diagnosed. Overall, conflicting evidence still exists to support a trend towards early diagnosis and/or a change in the natural history of the disease. The localization of the von Hippel-Lindau (VHL) tumor suppressor gene and other regions on chromosome 3p have contributed significantly to our understanding of the molecular genetics of both familial and sporadic RCC. Moreover, distinction between different cell types of RCC are being made at the molecular and genetic level. A relationship between environmental factors, such as cigarette smoking, and these genetic disturbances has yet to be determined. Although different determinants of nuclear grading are being proposed as prognostic factors, no convincing evidence has been identified to support the use of other molecular markers, such as the p53 tumor suppressor gene and epidermal growth factor. With regard to treatment, beyond the role of surgery in organ-confined RCC, other therapies for RCC are limited. Furthermore, immunotherapy has shown the best promise by providing durable responses in patients with advanced disease.
ChemInform Abstract: Diazepinone Nucleosides as Inhibitors of Cytidine Deaminase. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Mitigation of Loopback Self-Interference in Full-Duplex MIMO Relays (2011)

Full-duplex relaying is more spectrally efficient than half-duplex relaying as only one channel use is needed per two hops. However, it is crucial to minimize relay self-interference to render full duplex feasible. For this purpose, we analyze a broad range of multiple-input multiple-output (MIMO) mitigation schemes: natural isolation, time-domain cancellation, and spatial suppression. Cancellation subtracts replicated interference signal from the relay input while suppression reserves spatial dimensions for receive and transmit filtering. Spatial suppression can be achieved by antenna subset selection, null-space projection, i.e., receiving and transmitting in orthogonal subspaces, or joint transmit and receive beam selection to support more spatial streams by choosing the minimum eigenmodes for overlapping subspaces. In addition, minimum mean square error (MMSE) filtering can be employed to maintain the desired signal quality, which is inherent for cancellation, and the combination of time- and spatial-domain processing may be better than either alone. Targeting at minimal interference power, we solve optimal filters for each scheme in the cases of joint, separate and independent design. The performance of mitigation schemes is evaluated and compared by simulations. The results confirm that self-interference can be mitigated effectively also in the presence of imperfect side information.
Deterministic bead-in-droplet ejection utilizing an integrated plug-in bead dispenser for single bead–based applications (2017)

This paper presents a deterministic bead-in-droplet ejection (BIDE) technique that regulates the precise distribution of microbeads in an ejected droplet. The deterministic BIDE was realized through the effective integration of a microfluidic single-particle handling technique with a liquid dispensing system. The integrated bead dispenser facilitates the transfer of the desired number of beads into a dispensing volume and the on-demand ejection of bead-encapsulated droplets. Single bead-encapsulated droplets were ejected every 3 s without any failure. Multiple-bead dispensing with deterministic control of the number of beads was demonstrated to emphasize the originality and quality of the proposed dispensing technique. The dispenser was mounted using a plug-socket type connection, and the dispensing process was completely automated using a programmed sequence without any microscopic observation. To demonstrate a potential application of the technique, bead-based streptavidin-biotin binding assay in an evaporating droplet was conducted using ultralow numbers of beads. The results evidenced the number of beads in the droplet crucially influences the reliability of the assay. Therefore, the proposed deterministic bead-in-droplet technology can be utilized to deliver desired beads onto a reaction site, particularly to reliably and efficiently enrich and detect target biomolecules.
Full Duplex MIMO Digital Beamforming with Reduced Complexity AUXTX Analog Cancellation (2020)

In this paper, we present an analog canceller architecture combined with transmit and receive digital beamforming for reduced complexity Full Duplex (FD) Multiple Input Multiple Output (MIMO) systems. Our proposed analog cancellation architecture comprises of AUXiliary (AUX) Transmitters (TX) and a novel use of DEMUltipleXers (DEMUX) that enables flexible signal routing for the signals at the AUXTX outputs. This signal routing allows a reduction in the number of AUXTX that are required for analog cancellation compared to State of the Art (SotA) architectures. We also present a novel transmit and receive beamforming design that takes into account the constraints imposed by the analog canceller architecture. We provide representative simulation results that demonstrate the superiority of our FD MIMO design compared to SotA approaches.
ArabidopsisPEROXIN11c-e, FISSION1b, and DYNAMIN-RELATED PROTEIN3A Cooperate in Cell Cycle–Associated Replication of Peroxisomes (2008)

Although participation of PEROXIN11 (PEX11), FISSION1 (FISl), and DYNAMIN-RELATED PROTEIN (DRP) has been well established during induced peroxisome proliferation in response to external stimuli, their roles in cell cycle-associated constitutive replication/duplication have not been fully explored. Herein, bimolecular fluorescence complementation experiments with Arabidopsis thaliana suspension cells revealed homooligomerization of all five PEX11 isoforms (PEX11a-e) and heterooligomerizations of all five PEX11 isoforms with FIS1b, but not FIS1a nor DRP3A. Intracellular protein targeting experiments demonstrated that FIS1b, but not FIS1a nor DRP3A, targeted to peroxisomes only when coexpressed with PEX11d or PEX11e. Simultaneous silencing of PEX11c-e or individual silencing of DRP3A, but not FIS1a nor FIS1b, resulted in approximately 40% reductions in peroxisome number. During G2 in synchronized cell cultures, peroxisomes sequentially enlarged, elongated, and then doubled in number, which correlated with peaks in PEX11, FIS1, and DRP3A expression. Overall, these data support a model for the replication of preexisting peroxisomes wherein PEX11c, PEX11d, and PEX11e act cooperatively during G2 to promote peroxisome elongation and recruitment of FIS1b to the peroxisome membrane, where DRP3A stimulates fission of elongated peroxisomes into daughter peroxisomes, which are then distributed between daughter cells.
ChemInform Abstract: The Chemistry and Occurrence of Taxane Derivatives. Part 17. New Taxoids from Taxus baccata L. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Membrane insertion of the pore‐forming domain of colicin A (1991)

In order to gain some insight into the mechanism of insertion into membranes of the pore-forming domain of colicin A and the structure of its membrane-bound form, circular dichroism (in the near and far ultraviolet), fluorescence and ultraviolet spectroscopy experiments were carried out. Because the structure of the water-soluble form of this fragment has been determined by X-ray crystallography, these spectroscopic methods provided valuable information on the secondary structure and the environment of aromatic residues within the two forms of the peptide. These results strongly suggest that the pore-forming domain of colicin A does not undergo drastic unfolding upon insertion into membrane. The conformational change associated with this process is triggered by the negatively charged lipids and probably consists of a reorientation of helix pairs with respect to each other. Exposure of the aromatic residues to the aqueous phase decreases on binding to lipids whilst the exposure of the tryptophans to the membrane phase increases. This cannot occur without a reorientation of helices 3-10. All data from this study support the model presented previously in which the known crystal structure opens like an 'umbrella' inserting the hydrophobic hairpin (helix 8-9) perpendicular to the membrane plane and the helical pair 1-2 and the domain containing the three tryptophans (helices 3-7) lying more or less parallel to the membrane plane. Lipids are bound more tightly to the protein at acidic pH than at neutral pH although a similar lipid protein complex is formed with 1,2-dimyristoyl-sn-glycero(3)-phospho(1)- -sn-glycerol at both pH values.
Double Recessed GaAs pHEMTs for 20-50 V Power Switching (2013)

A normally-OFF RF pHEMT process is optimized for a blocking voltage in the 20-50V range for power switching ICs. Due to their superior material properties, the intrinsic figure of merit for pHEMT switching devices show an order of magnitude improvement over the state-of-the-art Silicon NMOS transistors and in the same range as lateral GaN HEMTs. In a scenario where innovations in silicon based low voltage power transistors have saturated, this approach is a new way of breaking the paradigm and making large leaps in performance.
Whole genome sequencing delineates regulatory and novel genic variants in childhood cardiomyopathy (2020)

ABSTRACT Cardiomyopathy (CMP) is a heritable genetic disorder. Protein-coding variants account for 20-30% of cases. The contribution of variants in non-coding DNA elements that regulate gene expression has not been explored. We performed whole-genome sequencing (WGS) of 228 unrelated CMP families. Besides pathogenic protein-coding variants in known CMP genes, 5% cases harbored rare loss-of-function variants in novel cardiac genes, with NRAP and FHOD3 being strong candidates. WGS also revealed a high burden of high-risk variants in promoters and enhancers of CMP genes in an additional 20% cases (Odds ratio 2.14, 95% CI 1.60-2.86, p=5.26×10 −7 vs 1326 controls) with genes involved in α-dystroglycan glycosylation ( FKTN, DTNA ) and desmosomal signaling ( DSC2, DSG2 ) specifically enriched for regulatory variants (False discovery rate &lt;0.03). These findings were independently replicated in the Genomics England CMP cohort (n=1266). The functional effect of non-coding variants on transcription was functionally validated in patient myocardium and reporter assays in human cardiomyocytes, and that of novel gene variants in zebrafish knockouts. Our results show that functionally active variants in novel genes and in regulatory elements of CMP genes contribute strongly to the genomic etiology of childhood-onset CMP.
Definition and clinical validation of Pain Patient States from high-dimensional mobile data: application to a chronic pain cohort (2022)

The technical capacity to monitor patients with a mobile device has drastically expanded, but data produced from this approach are often difficult to interpret. We present a solution to produce a meaningful representation of patient status from large, complex data streams, leveraging both a data-driven approach, and use clinical knowledge to validate results. Data were collected from a clinical trial enrolling chronic pain patients, and included questionnaires, voice recordings, actigraphy, and standard health assessments. The data were reduced using a clustering analysis. In an initial exploratory analysis with only questionnaire data, we found up to 3 stable cluster solutions that grouped symptoms on a positive to negative spectrum. Objective features (actigraphy, speech) expanded the cluster solution granularity. Using a 5 state solution with questionnaire and actigraphy data, we found significant correlations between cluster properties and assessments of disability and quality- of-life. The correlation coefficient values showed an ordinal distinction, confirming the cluster ranking on a negative to positive spectrum. This suggests we captured novel, distinct Pain Patient States with this approach, even when multiple clusters were equated on pain magnitude. Relative to using complex time courses of many variables, Pain Patient States holds promise as an interpretable, useful, and actionable metric for a clinician or caregiver to simplify and provide timely delivery of care.
Selective hydrodeoxygenation of acetophenone derivatives using a Fe25Ru75@SILP catalyst: a practical approach to the synthesis of alkyl phenols and anilines (2022)

Fe 25 Ru 75 @SILP acts as a highly active and selective catalyst for the hydrodeoxygenation of readily available hydroxy-, amino-, and nitro-acetophenone derivatives to valuable alkyl phenols and anilines.
SI Model to Hardware Correlation on a 44 Gb/s HLGA Socket Connector (2020)

A comprehensive signal integrity model to hardware correlation study on an improved, 44 Gb/s capable, hybrid land grid array (HLGA) socket connector design is presented. The connector only design SI performance is shown through 3D electromagnetic (EM) modelling. Details of the test vehicle designed to carry out the connector hardware evaluation are shown. Simulation modelling and experimental results of the test vehicle inclusive of the connector are presented and compared. The systematic testing ensures that the new component performs up to its required specifications which ensures successful operation at the system level.
Feasibility study on a prototype of vestibular implant using MEMS gyroscopes (2003)

This paper presents a feasibility study on an MEMS-based implantable vestibular prosthesis. Our end-goal is to design a prosthesis that will replace the function of the damaged vestibular end-organ by providing an MEMS chip that will accurately sense, extract, and transmit 3-dimensional motion information for people who have permanently lost peripheral vestibular function. The prosthesis prototype includes orthogonal triads of accelerometers and gyroscopes on-a-single fingernail sized chip. Based on physiological data on perceptual thresholds of linear acceleration and angular velocity in humans, we conclude that the MEMS technology is a viable candidate for such an implant. Functional architecture for the vestibular prosthesis is introduced.
Hard magnetism in structurally engineered silica nanocomposite (2016)

Creation of structural complexity by simple experimental control will be an attractive approach for the preparation of nanomaterials, as a classical bottom-up method is supplemented by a more efficient and more direct artificial engineering method. In this study, structural manipulation of MCM-41 type mesoporous silica is investigated by generating and imbedding hard magnetic CoFe2O4 nanoparticles into mesoporous silica. Depending on the heating rate and target temperature, mesoporous silica undergoes a transformation in shape to form hollow silica, framed silica with interior voids, or melted silica with intact mesostructures. Magnetism is governed by the major CoFe2O4 phase, and it is affected by antiferromagnetic hematite (α-Fe2O3) and olivine-type cobalt silicate (Co2SiO4), as seen in its paramagnetic behavior at the annealing temperature of 430 °C. The early formation of Co2SiO4 than what is usually observed implies the effect of the partial substitution of Fe in the sites of Co. Under slow heating (2.5 °C min(-1)) mesostructures are preserved, but with significantly smaller mesopores (d100 = 1.5 nm). In addition, nonstoichiometric CoxFe1-xO with metal vacancies at 600 °C, and spinel Co3O4 at 700 °C accompany major CoFe2O4. The amorphous nature of silica matrix is thought to contribute significantly to these structurally diverse and rich phases, enabled by off-stoichiometry between Si and O, and accelerated by the diffusion of metal cations into SiO4 polyhedra at an elevated temperature.
Salicylamide-lanthanide complexes for use as luminescent markers (2023)

The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one salicylamidyl moiety. Also provided are probes incorporating the salicylamidyl ligands of the invention and methods utilizing the ligands of the invention and probes comprising the ligands of the invention.
Regional localization of the human transferrin receptor gene to 3q26.2----qter. (1985)

Transport of iron across the cell membrane is mediated by the iron-binding serum protein, transferrin, and its cell-surface receptor. Transferrin receptor is required for cell proliferation and may play a functional role in the pathogenesis of iron-storage disorders and some neoplasias. To better understand the possible involvement of transferrin receptor in such disorders, we have determined the chromosomal locus of the receptor gene by in situ hybridization. The human transferrin receptor gene was thus mapped to 3q26.2----qter, a region of chromosome 3 that appears to be involved in metal transport and that is subject to nonrandom structural rearrangements associated with neoplasia.
This Month in Investigative Urology (2006)

No AccessJournal of UrologyThis month in investigative urology1 May 2006This Month in Investigative Urology Anthony Atala Anthony AtalaAnthony Atala More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(06)00433-2AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "This Month in Investigative Urology." The Journal of Urology, 175(5), pp. 1595–1596 © 2006 by American Urological AssociationFiguresReferencesRelatedDetails Volume 175Issue 5May 2006Page: 1595-1596 Advertisement Copyright & Permissions© 2006 by American Urological AssociationMetricsAuthor Information Anthony Atala More articles by this author Expand All Advertisement Loading ...
Supplementary Figure 4 from CUL4A Induces Epithelial–Mesenchymal Transition and Promotes Cancer Metastasis by Regulating ZEB1 Expression (2023)

&lt;p&gt;PDF file - 275K, Supplemental Figure 4. Representative images of immunostaining and quantification of Ki67 positive cells in xenograft tumors formed from MDA-MB 468 CUL4 (A) and MDA-MB 231 shCUL4A (B) cells.&lt;/p&gt;
ChemInform Abstract: AN UNUSUALLY FACILE THIOALLYLIC REARRANGEMENT ‐ STEREOCHEMICAL EVIDENCE FOR A FREE RADICAL CHAIN MECHANISM (1982)

Abstract Bei der Diels‐Alder‐Reaktion des Diens (Ia) mit dem Chinon (II) läßt sich′eine Allylumlagerung beobachten, die nach anschließender Hydrolyse das Addukt (III) liefert.
Supplementary Figure 4 from PI3K Inhibition Impairs BRCA1/2 Expression and Sensitizes BRCA-Proficient Triple-Negative Breast Cancer to PARP Inhibition (2023)

&lt;p&gt;PDF file - 3.4MB, Concordance in ER, PR, HER2, and PTEN expression between original patient tumors and the derived tumor grafts&lt;/p&gt;
All-Metal Graded Index Gutman Lens Antenna - A More Compact Luneburg Lens (2020)

The present work introduces an all-metal Gutman lens antenna in a parallel plate waveguide (PPW) technology for space applications at Ku band. Compared to the Luneburg lens, the Gutman lens provides more compact size up to 35%. To achieve this compactness an optimized unit cell with glide symmetry is utilized. Single ridge waveguides are proposed to excite the lens along its focal arc to obtain a field of view with high beam overlap level between adjacent beams. Finally, the antenna presents broadband performance up to 40% with low losses and high directivity which makes it an excellent candidate for satellite missions.
Perceptual Quality Assessment of Immersive Images Considering Peripheral Vision Impact (2018)

Conventional images/videos are often rendered within the central vision area of the human visual system (HVS) with uniform quality. Recent virtual reality (VR) device with head mounted display (HMD) extends the field of view (FoV) significantly to include both central and peripheral vision areas. It exhibits the unequal image quality sensation among these areas because of the non-uniform distribution of photoreceptors on our retina. We propose to study the sensation impact on the image subjective quality with respect to the eccentric angle $θ$ across different vision areas. Often times, image quality is controlled by the quantization stepsize $q$ and spatial resolution $s$, separately and jointly. Therefore, the sensation impact can be understood by exploring the $q$ and/or $s$ in terms of the $θ$, resulting in self-adaptive analytical models that have shown quite impressive accuracy through independent cross validations. These models can further be applied to give different quality weights at different regions, so as to significantly reduce the transmission data size but without subjective quality loss. As demonstrated in a gigapixel imaging system, we have shown that the image rendering can be speed up about 10$\times$ with the model guided unequal quality scales, in comparison to the the legacy scheme with uniform quality scales everywhere.