gebhart/patrepeval huggingface dataset:
Performance evaluation platform for xDSL deployment in a complex multi-segment environment (2004)

This paper presents a highly flexible simulation platform catering to the easy and rapid evaluation of existing and future digital subscriber line (DSL) deployments as well as DSL modem performance prediction using practical modem implementations in a complex multi-segment environment. The paper outlines the methodology employed to architect and develop the core software, followed by a description of the performance prediction hooks for a variety of current and future DSL modem technologies. The graphical user interface (GUI) abstracting the core software for the user is described in terms of the various configuration options and the quick and easy graphical design of typical and complex deployment scenarios. The proposed simulator's calculations, notably theoretical SNR margin, maximum theoretical capacity and reach, plus performance evaluation using user-designed modem models, are also outlined. To support the accuracy of the new simulator, results for some example scenarios are presented and compared against other available simulators.
Ligamentous structures of the metacarpophalangeal joint: A quantitative anatomic study (1983)

The ligamentous structure of the metacarpophalangeal (MCP) joint of the index finger in human cadavers was studied by gross examination and quantitative measurement. Anatomically, the collateral ligament is separable into two layers, with the precise origin arising from the metacarpal head and inserting on the proximal phalanx. Quantitatively, the change in length of the collateral ligament was studied with biplanar radiographic techniques. The distance between the origin and insertion of the collateral ligament changed in different portions of the ligament when the joint was moved from a position of hyperextension to that of flexion. When the MCP joint was flexed from 0 degree to 80 degrees, the dorsal portions of both the radial and ulnar collateral ligaments were lengthened (3-4 mm). The middle portions of both ligaments were slightly elongated (0.4-1.0 mm), and the volar portions of the ligaments were shortened (1-2 mm). When the MCP joint extended into hyperextension, the dorsal portions of the ligaments shortened 2-3 mm, the middle thirds of the ligaments shortened slightly, and the volar thirds of the ligaments lengthened. The results of this study suggest that the dorsal and volar portions of the collateral ligament provide MCP joint constraint at the flexed and extended positions, respectively.
An investigation of natural circulation decay heat removal from an SP-100 reactor system for a lunar outpost (1992)

A transient thermal‐hydraulic model of the decay heat removal from a 550 kWe SP‐100 power system for a lunar outpost has been developed and used to assess the coolability of the system by natural circulation after reactor shutdown. Results show that natural circulation of lithium coolant is sufficient to ensure coolability of the reactor core after shutdown. Further improvement of the decay heat removal capability of the system could be achieved by increasing the dimensions of the decay heat exchanger duct. A radiator area of 10‐15 m2 would be sufficient to maintain the reactor core safely coolable by natural circulation after shutdown. Increasing the area of the decay heat rejection radiator or the diameter of the heat pipes in the guard vessel wall insignificantly affects the decay heat removal capability of the system.
Unsupervised Link Selection in Networks (2013)

Real-world networks are often noisy, and the existing linkage structure may not be reli-able. For example, a link which connects nodes from different communities may affect the group assignment of nodes in a negative way. In this paper, we study a new problem called link selection, which can be seen as the network equivalent of the traditional feature selection problem in machine learning. More specifically, we investigate unsupervised link selection as follows: given a network, it se-lects a subset of informative links from the original network which enhance the quality of community structures. To achieve this goal, we use Ratio Cut size of a network as the quality measure. The resulting link selection approach can be formulated as a semi-definite programming problem. In order to solve it efficiently, we propose a backward elimina-tion algorithm using sequential optimization. Experiments on benchmark network datasets illustrate the effectiveness of our method. 1
Molecular and Functional Characterization of an Invertase Secreted by Ashbya gossypii (2014)

The repertoire of hydrolytic enzymes natively secreted by the filamentous fungus Ashbya (Eremothecium) gossypii has been poorly explored. Here, an invertase secreted by this flavinogenic fungus was for the first time molecularly and functionally characterized. Invertase activity was detected in A. gossypii culture supernatants and cell-associated fractions. Extracellular invertase migrated in a native polyacrylamide gel as diffuse protein bands, indicating the occurrence of at least two invertase isoforms. Hydrolytic activity toward sucrose was approximately 10 times higher than toward raffinose. Inulin and levan were not hydrolyzed. Production of invertase by A. gossypii was repressed by the presence of glucose in the culture medium. The A. gossypii invertase was demonstrated to be encoded by the AFR529W (AgSUC2) gene, which is highly homologous to the Saccharomyces cerevisiae SUC2 (ScSUC2) gene. Agsuc2 null mutants were unable to hydrolyze sucrose, proving that invertase is encoded by a single gene in A. gossypii. This mutation was functionally complemented by the ScSUC2 and AgSUC2 genes, when expressed from a 2-μm-plasmid. The signal sequences of both AgSuc2p and ScSuc2p were able to direct the secretion of invertase into the culture medium in A. gossypii.
Collaborative Hierarchical Sparse Modeling (2010)

Sparse modeling is a powerful framework for data analysis and processing. Traditionally, encoding in this framework is done by solving an l_1-regularized linear regression problem, usually called Lasso. In this work we first combine the sparsity-inducing property of the Lasso model, at the individual feature level, with the block-sparsity property of the group Lasso model, where sparse groups of features are jointly encoded, obtaining a sparsity pattern hierarchically structured. This results in the hierarchical Lasso, which shows important practical modeling advantages. We then extend this approach to the collaborative case, where a set of simultaneously coded signals share the same sparsity pattern at the higher (group) level but not necessarily at the lower one. Signals then share the same active groups, or classes, but not necessarily the same active set. This is very well suited for applications such as source separation. An efficient optimization procedure, which guarantees convergence to the global optimum, is developed for these new models. The underlying presentation of the new framework and optimization approach is complemented with experimental examples and preliminary theoretical results.
Dynamic Binary Tree for Hierarchical Clustering of IP Traffic (2007)

This paper proposes a computational and memory-efficient technique for online unidimensional clustering of individual IP addresses in order to detect high-volume traffic clusters (hierarchical heavy hitters). Our technique is based on a Patricia tree and can cope with today's traffic volume. We test our algorithm by using a traffic trace composed of NetFlow records sent by a few tens of routers of the France telecom IP backbone network. We moreover show how our algorithm can be used for network anomaly detection.
Urban political economy beyond convergence (2018)

This chapter discusses the transformations of contemporary European cities and is intellectually influenced by the Italian political economy tradition, which is particularly attentive to territories and cities. This tradition paved the way for sophisticated intellectual arguments about social networks, religion, crime, the role of the middle classes articulated to different processes of non-economic factors of economic development, the welfare state, relations of the labour market and poverty. The chapter reviews the ongoing dynamics of the bulk of European metropolises together with the differentiation processes taking place. The European city model has been rather reinforced in most European metropolises. The chapter argues that both contemporary urbanisation processes and the transformation of cities in Europe might be fruitfully explained in relation to social and political transformations as articulated in the Italian tradition of political economy than in terms of neoliberalisation.
Modulation of the activity and assessment of the receptor selectivity in a series of new RGD‐containing peptides (1993)

We have investigated the structure-activity relationship of a series of new synthetic RGD analogs and their potential use as specific platelet aggregation inhibitors. Twelve short linear peptides showed high potency to inhibit aggregation in ADP-stimulated dog platelets. In order to assess the selectivity of these analogs towards platelet integrin GPIIb-IIIa, a new cell adhesion inhibition system was devised which was able to discriminate between the two closely related beta 3-integrins of the vasculature, GPIIb-IIIa (alpha IIb beta 3), present in platelets, and the vitronectin receptor (alpha v beta 3), expressed in endothelial cells and platelets. As reported for other peptides by Scarborough et al. (1993, J. Biol. Chem. 268, 1066), the analogs containing lysine instead of arginine in position 1 showed increased selectivity towards GPIIb-IIIa. One of them, in which the piperidine carboxylic group was attached to the N-terminus of KGDW, not only strongly inhibited platelet aggregation, but also selectively abolished cell adhesion mediated by GPIIb-IIIa without effect on the vitronectin receptor.
Abstract IA26: Developing effective community and health system partnerships to advance health equity and health disparities research (2018)

Abstract Establishing sustainable and impactful partnerships to advance health equity and health disparities research requires a multipronged approach to assessing and aligning community and organizational priorities toward common goals and objectives. Partnerships to advance health equity and to ensure ongoing and meaningful health disparities research should ideally provide a win-win for community stakeholders and the health system. This often requires a cultural shift regarding how and to what extent academic/medical institutions value and fully engage diverse stakeholders as experts in the research process and delivery of care. At the Duke Cancer Institute, through the Office of Health Equity and Disparities, our intentional stakeholder engagement has led to robust partnerships with diverse community organizations and leaders capitalizing on each other's strengths and expertise. Through this process the DCI, together with the community, has built a sustainable platform to advance health equity through research, capacity building, and open communication. Citation Format: Nadine Barrett, Kearston Ingraham, Kevin Williams, Pao-Hwa Lin, Howard Eisenson, Maritza Chirinos, Demetrius Harvey, Steven Patierno. Developing effective community and health system partnerships to advance health equity and health disparities research [abstract]. In: Proceedings of the Tenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2017 Sep 25-28; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2018;27(7 Suppl):Abstract nr IA26.
The composition effect on the optical properties of aqueous synthesized Cu–In–S and Zn–Cu–In–S quantum dot nanocrystals (2015)

Multiternary quantum dots (QDs), because of the large degree of freedom in their structure and composition, have a wide tunability in their bandgap but also exhibit an increased uncertainty and complexity in their optical properties. In this work, we synthesized the ternary Cu-In-S (CIS) and quaternary Zn-Cu-In-S (ZCIS) QDs with different composition ratios via a facile aqueous route. The CIS QDs show multi-peak photoluminescence with their peak intensity dependent on the Cu : In ratio, which was illustrated using a donor-acceptor pair recombination process. Upon incorporation of Zn into the CIS QDs under similar conditions, the acquired ZCIS QDs exhibit blue-shifted photoluminescence (PL) spectra with an enhanced emission intensity and a narrowed spectral width (∼100 nm). A comparative study reveals that, reducing the Cu : In ratio in the CIS QDs and increasing the Zn content in the alloyed ZCIS QDs are both feasible strategies for bandgap engineering, although the influences on optical properties of the QDs were different. The XRD and EDX spectra revealed that the widening of the bandgap of the ZCIS QDs was correlated with the alloyed nanostructures and the preferential substitution of Cu by Zn. Compared to the Cu : In ratio variation, incorporation of Zn into CIS QDs is an effective strategy to achieve a more homogeneous absorption band and a wide range of emission wavelength tunability. After ZnS shell coating, the ZCIS/ZnS QDs show a further enhanced PL intensity with a prolonged fluorescence lifetime. Unlike CIS QDs, the blue shift in PL upon the shell growth was not pronounced for ZCIS QDs, for which a surface reconstruction mechanism was proposed and discussed. Finally, the as-prepared ZCIS/ZnS QDs were employed for in vitro cell imaging and exhibited good biocompatibility to macrophage cells.
Allogeneic Stem Cell–Derived “Repair Unit” Therapy and the Barriers to Clinical Deployment (2004)

The development of cellular therapies has been seriously hampered by the paucity of cells available for grafting from living or cadaver donors. This sourcing problem can be resolved, at least in theory, by generating tissue-specific cells from autologous or allogeneic stem cells. Nonetheless, there are formidable barriers to the use of stem cells in the clinic. This review focuses on identifying and surmounting these barriers.
From model to mechanism: lessons of mice and men in the discovery of protein biologicals for the treatment of inflammatory bowel disease (2006)

Successful therapeutics for inflammatory bowel disease (IBD) must be able to reverse effectively the complex processes involved in the manifestation of inflammatory pathology in intact tissues. Although studies of human tissue samples are important to confirm the biological rationale for developing a particular therapeutic, in vivo rodent models of IBD provide a biological 'flask' in which therapeutics can be tested in a more representative setting. Moreover, gene targeting and transgenic technologies in rodents have exponentially increased the repertoire of available IBD models and provided insight into possible contributions that certain genes may have in the pathogenesis of disease. These models have been key in generating the current arsenal of biological therapeutics that are available, or are presently under investigation, for the treatment of IBD patients.
Magnetic Targeting of Particle Transport Under Pulsatile Flow (2006)

Magnetic Drug Targeting (MDT) has been shown to be a promising technique to effectively deliver medicinal drugs via functionalized [1] magnetic particles to target sites during the treatment of cancer and other diseases [2,3,4]. In this paper, we investigate the interaction of steady and pulsatile flows injected with a ferrofluid, which is a colloidal suspension of superparamagnetic nanoparticles in a glass tube under the influence of a magnetic field. Ferrofluids are colloidal suspensions of single domain magnetic nanoparticles that are of the order of 10 nm in diameter. In this experiment, the ferrofluid particles were directed to a particular region of interest within a 10 mm diameter glass vessel by means of an applied localized magnetic field that originated outside of the vessel. The magnetic field was generated using a rare earth sintered permanent magnet which produced the magnetic field gradient required for inducing a body force on the volume of the ferrofluid. The experimental results reveal flows with rich dynamical phenomena. The aggregation of the ferrofluid produces a self-assembled hemispherical structure which dynamically interacts with the host flow. The aggregation generates an occlusion creating a flow field that is similar to that past an obstruction. However, since the structure itself is of a fluidic nature, it is subject to shear forces caused by the host fluid. In addition, the wake of the flow behind the aggregation creates vortices which are critical to study the stability of the ferrofluid aggregate. This paper presents a detailed investigation of the dynamics of the flow using Time-Resolved Digital Particle Image Velocimetry. To the best of the authors’ knowledge, these are the first quantitative, spatiotemporally resolved measurements documenting the interaction of a host fluid with a ferrofluid aggregate under steady or pulsatile flow conditions.
Enantiomeric Separation and Simulation Studies of Pheniramine, Oxybutynin, Cetirizine, and Brinzolamide Chiral Drugs on Amylose‐Based Columns (2014)

Solid phase extraction (SPE)-chiral separation of the important drugs pheniramine, oxybutynin, cetirizine, and brinzolamide was achieved on the C18 cartridge and AmyCoat (150 x 46 mm) and Chiralpak AD (25 cm x 0.46 cm id) chiral columns in human plasma. Pheniramine, oxybutynin, cetirizine, and brinzolamide were resolved using n-hexane-2-PrOH-DEA (85:15:0.1, v/v), n-hexane-2-PrOH-DEA (80:20:0.1, v/v), n-hexane-2-PrOH-DEA (70:30:0.2, v/v), and n-hexane-2-propanol (90:10, v/v) as mobile phases. The separation was carried out at 25 ± 1 ºC temperature with detection at 225 nm for cetirizine and oxybutynin and 220 nm for pheniramine and brinzolamide. The flow rates of the mobile phases were 0.5 mL min(-1). The retention factors of pheniramine, oxybutynin, cetirizine and brinzolamide were 3.25 and 4.34, 4.76 and 5.64, 6.10 and 6.60, and 1.64 and 2.01, respectively. The separation factors of these drugs were 1.33, 1.18, 1.09 and 1.20 while their resolutions factors were 1.09, 1.45, 1.63 and 1.25, and 1.15, respectively. The absolute configurations of the eluted enantiomers of the reported drugs were determined by simulation studies. It was observed that the order of enantiomers elution of the reported drugs was S-pheniramine > R-pheniramine; R-oxybutynin > S-oxybutynin; S-cetirizine > R-cetirizine; and S-brinzolamide > R-brinzolamide. The mechanism of separation was also determined at the supramolecular level by considering interactions and modeling results. The reported SPE-chiral high-performance liquid chromatography (HPLC) methods are suitable for the enantiomeric analyses of these drugs in any biological sample. In addition, simulation studies may be used to determine the absolute configuration of the first and second eluted enantiomers.
Additions and Corrections - Stereoselective Synthesis and Biological Activity of β -and α-D-Arabinose 1,5-Diphosphate: Analogues of a Potent Metabolic Regulator (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAdditions and Corrections - Stereoselective Synthesis and Biological Activity of β -and α-D-Arabinose 1,5-Diphosphate: Analogues of a Potent Metabolic RegulatorBruce Maryanoff, Allen Reitz, Gene Tutwiler, Stephen Benkovic, Patricia Benkovic, and Simon PilkisCite this: J. Am. Chem. Soc. 1985, 107, 17, 5025Publication Date (Print):August 1, 1985Publication History Published online31 March 2004Published inissue 1 August 1985https://pubs.acs.org/doi/10.1021/ja00303a602https://doi.org/10.1021/ja00303a602research-articleACS PublicationsRequest reuse permissionsArticle Views20Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A 96-channel full data rate direct neural interface in 0.13µm CMOS (2011)

A power and area efficient sensor interface consumes 6.5 mW from 1.2 V supplies while occupying 5 mm × 5 mm in 0.13 µm CMOS. The interface enables full bandwidth access to 96 channels of data acquired from cortical microelectrodes as part of a head-mounted wireless recording system for unconstrained primate neuroscience experiments. Open loop amplification and switched-capacitor (SC) filtering with 2.2 µVrms input referred noise conditions the signals before conversion by 10-bit SAR ADCs with 60.3 dB SNDR and 41.5 fJ/conv step.
Structural Modification of the 3,4,5-Trimethoxyphenyl Moiety in the Tubulin Inhibitor VERU-111 Leads to Improved Antiproliferative Activities (2018)

Colchicine binding site inhibitors (CBSIs) hold great potential in developing new generations of antimitotic drugs. Unlike existing tubulin inhibitors such as paclitaxel, they are generally much less susceptible to resistance caused by the overexpression of drug efflux pumps. The 3,4,5-trimethoxyphenyl (TMP) moiety is a critical component present in many CBSIs, playing an important role in maintaining suitable molecular conformations of CBSIs and contributing to their high binding affinities to tubulin. Previously reported modifications to the TMP moiety in a variety of scaffolds of CBSIs have usually resulted in reduced antiproliferative potency. We previously reported a potent CBSI, VERU-111, that also contains the TMP moiety. Herein, we report the discovery of a VERU-111 analogue 13f that is significantly more potent than VERU-111. The X-ray crystal structure of 13f in complex with tubulin confirms its direct binding to the colchicine site. In addition, 13f exhibited a strong inhibitory effect on tumor growth in vivo.
Physical Activity into the Meal Glucose—Insulin Model of Type 1 Diabetes: In Silico Studies (2009)

A type 1 diabetes model also describing physical activity is proposed. The model represents a step forward to accurately describe glucose homeostasis in normal life conditions; however, further studies are needed to validate it against data.