gebhart/patrepeval huggingface dataset:
Metabolic and Genetic Determinants of Glucose Shape After Oral Challenge in Obese Youths: A Longitudinal Study (2020)

The prevalence of T-risk allele for the TCF7L2 rs7903146 prevailed in the late time-to-glucose peak group, which in turn is associated with impaired β-cell responsiveness to glucose (φ), thereby predisposing to prediabetes and diabetes in obese youths.
Stakeholder Engagement With Prototypes During Front-End Medical Device Design: Who Is Engaged With What Prototype? (2020)

Abstract Stakeholder engagement with prototypes during the front-end phases of medical device design can support problem identification, problem definition, and early concept generation. This study examined what prototypes were leveraged to engage specific types of stakeholders during front-end medical device design. Analysis of semi-structured interviews with 22 design practitioners in the medical device industry revealed some common associations of prototype choice for particular stakeholders. A few associations are highlighted: designers engaged users with physical three-dimensional (3D) prototypes, financial decision-makers with physical 3D and two-dimensional (2D) prototypes, government and regulatory stakeholders with 2D prototypes, and expert advisors with digital 3D prototypes. The rationale provided by practitioners revealed the intentional selection of prototype form for specific stakeholder engagements.
Conjugated Polyelectrolyte Blend with Polyethyleneimine Ethoxylated for Thickness-Insensitive Electron Injection Layers in Organic Light-Emitting Devices (2018)

Electron injection layers (EILs) based on a simple polymer blend of polyethyleneimine ethoxylated (PEIE) and poly[(9,9-bis(3'-(( N, N-dimethyl)- N-ethylammonium)-propyl)-2,7-fluorene)- alt-2,7-(9,9-dioctylfluorene)] (PFN-Br) can suppress the dependence of organic light-emitting device (OLED) performance on thickness variation compared with single PEIE or PFN-Br EILs. PEIE and PFN-Br were compatible with each other and PFN-Br uniformly mixed in the PEIE matrix. PFN-Br in PEIE formed more fluorene-fluorene pairs than PFN-Br alone. In addition, PEIE:PFN-Br blends reduced the work function (WF) substantially compared with single PEIE or PFN-Br polymer. PEIE:PFN-Br blends were applied to EILs in fluorescent polymer-based OLEDs. Optimized PEIE:PFN-Br blend EIL-based devices presented lower driving voltages and smaller dependences of device performance on EIL thickness than single PEIE or PFN-Br-based devices. These improvements were attributed to electron-transporting fluorene moieties, increased fluorene-fluorene pairs working as channels of electron transport, and the large WF reduction effect of PEIE:PFN-Br blends.
Matrix modifier and L'vov platform for elimination of matrix interferences in the analysis of fish tissues for lead by graphite furnace atomic absorption spectrometry (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMatrix modifier and L'vov platform for elimination of matrix interferences in the analysis of fish tissues for lead by graphite furnace atomic absorption spectrometryThomas W. May and William G. BrumbaughCite this: Anal. Chem. 1982, 54, 7, 1032–1037Publication Date (Print):June 1, 1982Publication History Published online1 May 2002Published inissue 1 June 1982https://pubs.acs.org/doi/10.1021/ac00244a005https://doi.org/10.1021/ac00244a005research-articleACS PublicationsRequest reuse permissionsArticle Views94Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Energy efficiency, carbon emissions, and thermal comfort comparisons between conventional and proposed clustered open courtyard housing using CEB blocks (2022)

Abstract This research aims to assess a compact economic housing model design proposal using walls constructed of compressed earth blocks as a nucleus for sustainable urban housing in Egypt. This research also aims to evaluate the effect of the direction of the proposed compact building on the building’s internal thermal comfort, energy consumption, and carbon dioxide emissions. According to previous studies, residential buildings represent about 50% of land uses in Egyptian cities, consume about 19% of the energy produced, and are responsible for 10% of carbon dioxide emissions. All previous environmental studies commended the thermal performance of courtyard buildings in the hot-arid climate of which Egypt is a part. As a result, the authors directed many previous studies towards new housing patterns in Egyptian cities using court-yarded clustered housing to improve thermal performance, decrease energy consumption, and reduce carbon dioxide emissions. This research compares two residential buildings using design-builder simulation. The two buildings have the same housing unit area of 90 m 2 to represent the social housing unit area in Egyptian cities. The first comparative building is a conventional residential building surrounded by solar radiation from all sides and uses walls constructed of solid cement bricks (SCB). The second comparative building is a cluster open court-yarded building using walls built of Compressed Earth Blocks (CEB). Results show that both the clustered open courtyard housing model whose main axis is in the (N-S) direction and the use of CEB has improved all of the examined measures.
Emerging trends in plasma‐free manufacturing of recombinant protein therapeutics expressed in mammalian cells (2009)

Mammalian cells are the expression system of choice for therapeutic proteins, especially those requiring complex post-translational modifications. Traditionally, these cells are grown in medium supplemented with serum and other animal- or human-derived components to support viability and productivity. Such proteins are also typically added as excipients and stabilizers in the final drug formulation. However, the transmission of hepatitis B in the 1970s and of hepatitis C and HIV in the 1980s through plasma-derived factor VIII concentrates had catastrophic consequences for hemophilia patients. Thus, due to regulatory concerns about the inherent potential for transmission of infectious agents as well as the heterogeneity and lack of reliability of the serum supply, a trend has emerged to eliminate the use of plasma-derived additives in the production and formulation of recombinant protein therapeutics. This practice began with products used in the treatment of hemophilia and is progressively expanding throughout the entire industry. The plasma-free method of producing recombinant therapeutics is accomplished by the use of both cell culture media and final product formulations that do not contain animal- or human-derived additives. A number of recombinant therapeutic proteins for the treatment of several different diseases have been produced by plasma-free processes, with the objective of improving safety by eliminating blood-borne pathogens or by reducing immunogenicity. This review describes the factors that drove the development of plasma-free protein therapeutics and provides examples of advances in manufacturing that have made possible the removal of human and animal-derived products from all steps of recombinant protein production.
Spectroscopic Observation and Molecular Dynamics Simulation of Ga Surface Segregation in Liquid Pd–Ga Alloys (2017)

Liquid binary Pd-Ga alloys with low Pd contents of 0.8, 1.8, and 4.7 at % of Pd were examined as a function of sample temperature in ultra-high vacuum by using angle-resolved XPS. Upon cooling from 750 to 400 K, a pronounced temperature-dependence of the Pd concentration in the liquid phase was observed, which was explained by the transition from the pure liquid phase to a two-phase system, consisting of a solid Ga<sub>5</sub> Pd phase and a Pd-depleted liquid Pd-Ga alloy. In the liquid Pd-Ga alloy, Pd is always depleted from the topmost interface layer, as deduced from angle-resolved XPS at 0 and 80° emission, independent of temperature and Pd concentration. This observation is interpreted as an inhomogeneous depth distribution function of Pd, that is, the segregation of Ga to the surface of the liquid phase. The results of a DFT-based molecular dynamics simulation (MD) independently show interfacial stratification of Ga and an inhomogeneous Pd distribution along the surface normal. The evaluation of the experimental data with a rigid layer model based on the MD calculations leads to excellent agreement with the simulation.
A Multi-Cluster-Based Distributed CDD Scheme for Asynchronous Joint Transmissions in Local and Private Wireless Networks (2021)

In this paper, a multiple cluster-based transmission diversity scheme is proposed for asynchronous joint transmissions (JT) in private networks. The use of multiple clusters or small cells is adopted to reduce the transmission distance to users thereby increasing data-rates and reducing latency. To further increase the spectral efficiency and achieve flexible spatial degrees of freedom, we consider that a distributed remote radio unit system (dRRUS) is installed in each of the clusters. A key characteristic of deploying the dRRUS in private networks is the associated multipath-rich and asynchronous delay propagation environment. Therefore, we consider asynchronous multiple signal reception at the remote radio units and propose an intersymbol interference free distributed cyclic delay diversity (dCDD) scheme for JT to achieve the full transmit diversity gain without requiring full channel state information of the private network. The spectral efficiency of the proposed dCDD-based JT is analyzed by deriving a new closed-form expression, and then compared with link-level simulations for non-identically distributed frequency selective fading over the entire network. Due to its distributed structure, the dRRUS relies on backhaul communications between the private network server and cluster master (CM), which is the main backhaul connection, and between the CM to remote radio units, which are the secondary backhaul connections. Thus, it is important for us to investigate the impact of reliability of main and secondary backhaul connections on the system. Our results show that the resulting composite backhaul connections can be accurately modeled by our proposed product of independent Bernoulli processes.
Dualsteric GPCR targeting: a novel route to binding and signaling pathway selectivity (2008)

Selective modulation of cell function by G protein-coupled receptor (GPCR) activation is highly desirable for basic research and therapy but difficult to achieve. We present a novel strategy toward this goal using muscarinic acetylcholine receptors as a model. The five subtypes bind their physiological transmitter in the highly conserved orthosteric site within the transmembrane domains of the receptors. Orthosteric muscarinic activators have no binding selectivity and poor signaling specificity. There is a less well conserved allosteric site at the extracellular entrance of the binding pocket. To gain subtype-selective receptor activation, we synthesized two hybrids fusing a highly potent oxotremorine-like orthosteric activator with M(2)-selective bis(ammonio)alkane-type allosteric fragments. Radioligand binding in wild-type and mutant receptors supplemented by receptor docking simulations proved M(2) selective and true allosteric/orthosteric binding. G protein activation measurements using orthosteric and allosteric blockers identified the orthosteric part of the hybrid to engender receptor activation. Hybrid-induced dynamic mass redistribution in CHO-hM(2) cells disclosed pathway-specific signaling. Selective receptor activation (M(2)>M(1)>M(3)) was verified in living tissue preparations. As allosteric sites are increasingly recognized on GPCRs, the dualsteric concept of GPCR targeting represents a new avenue toward potent agonists for selective receptor and signaling pathway activation.
Identification of Antiradical Hop Compounds (2008)

The radical scavenging capacity of pure hop compounds and their derivatives, including humulone (I) (α-acid), tetrahydrocohumulone (II), colupulone (III) (β-acid), hexahydro colupulone (IV), tetrahydrodesoxycohumulone (V), trans-iso-α-acids (VI), cis-ρ-iso-α-acids (VII), tetrahydroiso-α-acids (VIII), polyphenol fractions, and commercial hop products (hop pellets, CO2 hop extract, preisomerized hop pellets, and liquid/supercritical CO2-extracted hop solids from variety Galena), were assessed using a 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging method and validated using ESR-PBN spectroscopy (electron spin resonance with a spin trap of tert-butyl-phenylnitrone) during mashing and wort boiling and in finished beer. The DPPH radical assay revealed that pure hop compounds and the components of hop products having a six-member ring configuration (semi-quinone or quinoid) had the strongest radical suppression activity. The ESR-PBN technique results indicated that humulone (I), hop pellets, and CO2 hop extract had a distinctive heat protection property (radical suppression) during wort boiling and in finished beer.
Electrophoretic Deposition for Nanostructural Design of Catalyst Layers on Nafion Membrane (2007)

Nanostructural design of catalyst layers on 117 membrane was carried out by electrophoretic deposition (EPD) method. An ethanol suspension containing catalyst composite particles of Vulcan XC72 fine carbon-supported Pt catalyst and ionomer was utilized. The catalyst layers prepared were well attached to both sides of the membrane without mechanical pressing and heating processes, and their thicknesses were easily controlled in a submicrometer scale by the EPD duration and applied electric field intensity. As well, loading in the catalyst layer was controllable by content in the suspension. We applied transmission electron microscopy to characterize catalyst layers and revealed that those prepared by EPD method had porous structures compared to the hot-pressed one. These structures were favorable for fuel gas diffusion and formation of triple-phase boundaries, resulting in improvement of Pt utilization up to 76%. Accordingly, the membrane electrode assembly prepared by EPD method exhibited higher cell performance with less than half the amount of Pt loading compared with the hot-pressed membrane electrode assembly.
Synthesis and coplanarity-dependent HOMO–LUMO separation of π-conjugated dimers (2000)

Three series of dimers containing pyrrolo[3,4-e][2,1,3]benzothiadiazole units have been prepared by application of the Pd-catalyzed Suzuki coupling. The dependence of the HOMO–LUMO separation on coplanarity has been evaluated by means of electronic absorption spectra and cyclic voltammetry. The pyrrole dimer 5c shows a narrow HOMO–LUMO separation owing to its intrinsically planar structure, as confirmed by 1H NMR.
Consecutive case series with long-term follow-up of full macular translocation for myopic choroidal neovascularisation (2014)

FMT for mCNV maintained the improvement in VA for more than 5 years. However, postoperative complications and progression of chorioretinal atrophy due to myopia still seem to limit the visual improvement after FMT for mCNV.
Viral RNA polymerase complex promotes optimal growth of 1918 virus in the lower respiratory tract of ferrets (2008)

The 1918 influenza pandemic was the most devastating outbreak of infectious disease in human history, accounting for about 50 million deaths worldwide. In addition to a significant number of cases of secondary bacterial pneumonia, this highly pathogenic strain of influenza A virus caused fatal primary viral pneumonia. To identify the viral gene(s) chiefly responsible for the high virulence of the 1918 virus, we generated a series of reassortants between the 1918 virus and a contemporary human H1N1 virus (A/Kawasaki/173/2001; K173) using reverse genetics. We then assessed their virulence properties in ferrets, a model closely resembling humans in terms of sensitivity to influenza virus infection and pattern of spread after intranasal inoculation. Substitution of single genes from the 1918 virus in the genetic background of K173 virus did not markedly alter the pattern of infection. That is, the reassortants grew well in nasal turbinates, but only sporadically (if at all) in the trachea and lungs. One exception was the 1918PB1/K173 reassortant, which replicated efficiently in lung tissues as well as the upper respiratory tract. A reassortant virus expressing the 1918 viral RNA polymerase complex (PA, PB1, and PB2) and nucleoprotein showed virulence properties in the upper and lower respiratory tracts of ferrets that closely resembled those of wild-type 1918 virus. Our findings strongly implicate the viral RNA polymerase complex as a major determinant of the pathogenicity of the 1918 pandemic virus. This new insight may aid in identifying virulence factors in future pandemic viruses that could be targeted with antiviral compounds.
A 3.5-GHz band 140-W-class wideband feed-forward power amplifier for mobile base stations (2011)

This paper analyzes the characteristics when compensating for wideband intermodulation distortion (IMD) components of a fabricated 3.5-GHz band 140-W class feed-forward power amplifier (FFPA) for mobile base stations. The fabricated FFPA achieves the bandwidths of 160 MHz and 120 MHz when compensating for the IMD components for LTE signals with the bandwidths of 5 MHz and 20 MHz, respectively, when the output power is 40 dBm and the adjacent channel leakage power ratio is -45 dBc. Experimental and analysis results show that the FFPA compensates for the wideband IMD components when the IMD component compensation level is reduced. This paper shows that the FFPA is a worthwhile linearizer that compensates for 3.5-GHz band wideband IMD components.
Reinforcement learning on complex visual stimuli (2009)

DOAJ is a unique and extensive index of diverse open access journals from around the world, driven by a growing community, committed to ensuring quality content is freely available online for everyone.
Estimation of Interpersonal Relationships in Movies (2015)

In many movies, social conditions and awareness of the issues of the times are depicted in any form. Even if fantasy and science fiction are works far from reality, the character relationship does mirror the real world. Therefore, we try to understand social conditions of the real world by analyzing the movie. As a way to analyze the movies, we propose a method of estimating interpersonal relationships of the characters, using a machine learning technique called Markov Logic Network (MLN) from movie script databases on the Web. The MLN is a probabilistic logic network that can describe the relationships between characters, which are not necessarily satisfied on every line. In experiments, we confirmed that our proposed method can estimate favors between the characters in a movie with F-measure of 58.7%. Finally, by comparing the relationships with social indicators, we discussed the relevance of the movies to the real world.
Light‐Activation of DNA‐Methyltransferases (2021)

5-Methylcytosine (5mC), the central epigenetic mark of mammalian DNA, plays fundamental roles in chromatin regulation. 5mC is written onto genomes by DNA methyltransferases (DNMT), and perturbation of this process is an early event in carcinogenesis. However, studying 5mC functions is limited by the inability to control individual DNMTs with spatiotemporal resolution in vivo. We report light-control of DNMT catalysis by genetically encoding a photocaged cysteine as a catalytic residue. This enables translation of inactive DNMTs, their rapid activation by light-decaging, and subsequent monitoring of de novo DNA methylation. We provide insights into how cancer-related DNMT mutations alter de novo methylation in vivo, and demonstrate local and tuneable cytosine methylation by light-controlled DNMTs fused to a programmable transcription activator-like effector domain targeting pericentromeric satellite-3 DNA. We further study early events of transcriptome alterations upon DNMT-catalyzed cytosine methylation. Our study sets a basis to dissect the order and kinetics of diverse chromatin-associated events triggered by normal and aberrant DNA methylation.
Adaptive Ultrasound-Based Tractor Localization for Semi-Autonomous Vineyard Operations (2021)

Autonomous driving is greatly impacting intensive and precise agriculture. Matter-of-factly, the first commercial applications of autonomous driving were in autonomous navigation of agricultural tractors in open fields. As the technology improves, the possibility of using autonomous or semi-autonomous tractors in orchards and vineyards is becoming commercially profitable. These scenarios offer more challenges as the vehicle needs to position itself with respect to a more cluttered environment. This paper presents an adaptive localization system for (semi-) autonomous navigation of agricultural tractors in vineyards that is based on ultrasonic automotive sensors. The system estimates the distance from the left vineyard row and the incidence angle. The paper shows that a single tuning of the localization algorithm does not provide robust performance in all vegetation scenarios. We solve this issue by implementing an Extended Kalman Filter (EKF) and by introducing an adaptive data selection stage that automatically adapts to the vegetation conditions and discards invalid measurements. An extensive experimental campaign validates the main features of the localization algorithm. In particular, we show that the Root Mean Square Error (RMSE) of the distance is 16 cm, while the angular RMSE is 2.6 degrees.
Memory-based face recognition for visitor identification (2002)

We show that a simple, memory-based technique for appearance-based face recognition, motivated by the real-world task of visitor identification, can outperform more sophisticated algorithms that use principal components analysis (PCA) and neural networks. This technique is closely related to correlation templates; however, we show that the use of novel similarity measures greatly improves performance. We also show that augmenting the memory base with additional, synthetic face images results in further improvements in performance. Results of extensive empirical testing on two standard face recognition datasets are presented, and direct comparisons with published work show that our algorithm achieves comparable (or superior) results. Our system is incorporated into an automated visitor identification system that has been operating successfully in an outdoor environment since January 1999.