gebhart/patrepeval huggingface dataset:
Correlated Fading in Broadcast MIMO Channels: Curse or Blessing? (2008)

The impact of transmit correlation on the performance of limited feedback multi-user MIMO is investigated. Correlated fading is shown to highly influence the probability of scheduling orthogonal users and the ability to achieve small quantization errors. Correlated fading is indeed beneficial to MU- MIMO performance as it can potentially reduce the quantization error, if an appropriate codebook is used. Grassmanian line packing is very much inappropriate for MU-MIMO in correlated fading environments, while DFT-based codebooks and channel statistics-based codebooks are promising candidates. Additionally correlated fading is very beneficial to the scheduler. User correlation is shown to decrease more quickly in transmit correlated channels than in i.i.d. channels as the number of active users increases. However, correlated fading is also shown to be detrimental to the scheduler performance when the number of active users is rather small and cell sectorization is performed.
Abort-Safe Spacecraft Rendezvous on Elliptic Orbits (2022)

We develop a spacecraft rendezvous policy that ensures safe, collision-free trajectories under various thrust failure scenarios. We use backward reachable sets (RSs) to characterize the unsafe region where, if a failure occurs, a collision between a chaser and a target spacecraft cannot be avoided with the remaining available thrust. The chaser spacecraft is guided toward the target via model predictive control (MPC) that ensures abort safety by avoiding the unsafe region, which is locally convexified with half-spaces. Simulations of the rendezvous policy on various orbits demonstrate that the approach ensures safe aborts in the event of multiple thruster failures, passive abort safety under total thruster failure, and achieves some robustness to unmodeled orbital perturbations.
Photoinduced Energy Transfer Coupled to Charge Separation in a Ru(II)−Ru(II)−Acceptor Triad (2006)

The bichromophoric system Ru-Ru(C)-PI ([(bpy)3Ru-Ph-Ru(dpb)(Metpy-PI)][PF6]3, where bpy is 2,2'-bipyridine, Hdpb is 1,3-di(2-pyridyl)-benzene, Metpy is 4'-methyl-2,2':6',2' '-terpyridine and PI is pyromellitimide) containing two Ru(II) polypyridyl chromophores with a N6 and a N5C ligand set, respectively, was synthesized and characterized. Its photophysical properties were investigated and compared to those of the monochromophoric cyclometalated complexes Ru(C)-PI ([Ru(dpb)(Metpy-PI)][PF6]), Ru(C)-phi-PI ([Ru(dpb)(ttpy-PI)][PF6], ttpy is 4'-p-tolyl-2,2':6',2' '-terpyridine), Ru(C)-phi ([Ru(dpb)(ttpy)][PF6]), and Ru(C) ([Ru(dpb)(Metpy)][PF6]). Excitation of the Ru(C) unit in the dyads leads to oxidative quenching, forming the Ru(C)(III)-phi-PI*- and Ru(C)(III)-Pl.- charge-separated (CS) states with k(f)(ET) = 7.7 x 10(7) s(-1) (CH3CN, 298 K) in the tolyl-linked Ru(C)-phi-PI and k(f)(ET) = 4.4 x 10(9) s(-1) (CH2Cl2, 298 K) in the methylene-linked Ru(C)-PI. In the Ru-Ru(C)-PI triad, excitation of the Ru(C) chromophore leads to dynamics similar to those in the Ru(C)-PI dyad, generating the Ru(II)-Ru(C)(III)-PI*- CS state, whereas excitation of the Ru unit results in an initial energy transfer (k(EnT) = 4.7 x 10(11) s(-1)) to the cyclometalated Ru(C) unit. Subsequent electron transfer to the PI acceptor results in the formation of the same Ru(II)-Ru(C)(III)-PI*- CS state with k(f)(ET) = 5.6 x 10(9) s(-1) that undergoes rapid recombination with k(b)(ET) = 1 x 10(10) s(-1) (CH2Cl2, 298 K). The fate of the Ru(II)-Ru(C)(III)-PI*- CS state upon a second photoexcitation was studied by pump-pump-probe experiments in an attempt to detect the fully charge-separated Ru(III)-Ru(C)(II)-PI*- state.
Software Productivity of Field Experiments Using the Mobile Agents Open Architecture with Workflow Interoperability (2011)

We analyzed a series of ten systematically developed surface exploration systems that integrated a variety of hardware and software components. Design, development, and testing data suggest that incremental buildup of an exploration system for long-duration capabilities is facilitated by an open architecture with appropriate-level APIs, specifically designed to facilitate integration of new components. This improves software productivity by reducing changes required for reconfiguring an existing system.
The Austrian biodatabase for chronic myelomonocytic leukemia (ABCMML) (2019)

In the Austrian biodatabase for chronic myelomonocytic leukemia (ABCMML) clinicolaboratory real-life data have been captured from 606 CMML patients from 14 different hospitals over the last 30 years. It is the only large biodatabase worldwide in which functional methods such as semisolid in vitro cultures complement modern molecular methods such as next generation sequencing. This provides the possibility to comprehensively study the biology of CMML. The aim of this study was to compare patient characteristics with published CMML cohorts and to validate established prognostic parameters in order to examine if this real-life database can serve as a representative and useful data source for further research. After exclusion of patients in transformation characteristics of 531 patients were compared with published CMML cohorts. Median values for age, leukocytes, hemoglobin, platelets, lactate dehydrogenase (LDH) and circulating blasts were within the ranges of reported CMML series. Established prognostic parameters including leukocytes, hemoglobin, blasts and adverse cytogenetics were able to discriminate patients with different outcome. Myeloproliferative (MP) as compared to myelodysplastic (MD)-CMML patients had higher values for circulating blasts, LDH, RAS-pathway mutations and for spontaneous myelomonocytic colony growth in vitro as well as more often splenomegaly. This study demonstrates that the patient cohort of the ABCMML shares clinicolaboratory characteristics with reported CMML cohorts from other countries and confirms phenotypic and genotypic differences between MP-CMML and MD-CMML. Therefore, results obtained from molecular and biological analyses using material from the national cohort will also be applicable to other CMML series and thus may have a more general significance.
Prolyl Hydroxylase Domain 2 Protein Is a Strong Prognostic Marker in Human Gastric Cancer (2012)

Cytoplasmic PHD2 expression has a strong impact on survival in gastric cancer patients. Therefore, PHD2 represents a useful predictive biomarker in the evaluation of high-risk patients. Furthermore, these results underline the importance of PHD2 in gastric carcinogenesis and may identify PHD2 as a putative target for future gastric cancer therapy.
Degree of substitution of chlorin $e_{6}$ on charged poly- L-lysine chains affects their cellular uptake, localization and phototoxicity towards macrophages and cancer cells (2002)

Macromolecular photosensitizer conjugates are under investigation as improved delivery vehicles for dyes used in photodynamic therapy. We have previously described the use of conjugates between photosensitizers such as chlorin (c) and poly-L-lysine (pL) chains which are versatile molecular species because the size of the chain can be varied, and the overall charge can be altered from cationic through neutral to anionic. We now report on a series of pL-cconjugates in their cationic (native), neutral (acetylated) and anionic (succinylated) forms, where the number of c molecules attached to each chain was varied (pL: c ratios, 1:4, 1:8, 1:12, and 1:16). The fluorescence emissions were measured in both saline and a disaggregating solvent. We studied two cell lines (an epithelial ovarian cancer, OVCAR-5 and a mouse macrophage, J774) and measured cellular uptake, subcellular localization (by confocal fluorescence microscopy) and phototoxicity. The cellular uptake of the conjugates with four substitution ratios all delivered at 2 μM cequivalent concentration showed a maximum at 12 c per chain for both cationic and anionic conjugates, but the uptake of the neutral conjugate was proportional to the substitution ratio. The macrophages took up several times more c than the ovarian cancer cells. Confocal fluorescence micrographs showed more cellular fluorescence with the lower substitution ratios, and more lysosomal localization with the cationic conjugates. The phototoxicity was much higher for the neutral conjugates. For the cationic and neutral conjugates the 12 c per chain was the most effective at killing cells, while for the anionic conjugate it was the 16 c per chain. The anionic conjugate was better at killing OVCAR-5 cells, while the cationic was better for J774 cells, and the neutral was approximately the same. These data will help to optimize the parameters to be used in preparing polymeric-photosensitizer conjugates for photodynamic therapy.
Linkage between cellular communications, energy utilization, and proliferation in metastatic neuroendocrine cancers (2006)

To identify metabolic features that support the aggressive behavior of human neuroendocrine (NE) cancers, we examined metastatic prostate NE tumors and derived prostate NE cancer (PNEC) cell lines from a transgenic mouse model using a combination of magic angle spinning NMR spectroscopy, in silico predictions of biotransformations that observed metabolites may undergo, biochemical tests of these predictions, and electrophysiological/calcium imaging studies. Malignant NE cells undergo excitation and increased proliferation when their GABA(A), glutamate, and/or glycine receptors are stimulated, use glutamate and GABA as substrates for NADH biosynthesis, and produce propylene glycol, a precursor of pyruvate derived from glycine that increases levels of circulating free fatty acids through extra-NE cell effects. Treatment of nude mice containing PNEC tumor xenografts with (i) amiloride, a diuretic that inhibits Abp1, an enzyme involved in NE cell GABA metabolism, (ii) carbidopa, an inhibitor of dopa decarboxylase which functions upstream of Abp1, plus (iii) flumazenil, a benzodiazepine antagonist that binds to GABA(A) receptors, leads to significant reductions in tumor growth. These findings may be generally applicable: GeneChip data sets from 471 human neoplasms revealed that components of GABA metabolic pathways, including ABP1, exhibit statistically significant increases in their expression in NE and non-NE cancers.
Conformational Solvation Studies of LIGNOLs with Molecular Dynamics and Conductor-Like Screening Model (2012)

Molecular dynamics (MD) simulations were performed on sterically hindered α-conidendrin-based chiral 1,4-diols (LIGNOLs) from the naturally occurring lignan hydroxymatairesinol (HMR) using the GROMACS software. The aim of this study was to explore the conformational behaviour of the LIGNOLs in aqueous solution adopting the TIP4P model. The topologies of the LIGNOLs were constructed manually and they were modeled with the OPLS-AA force field implemented in GROMACS. The four most relevant torsional angles in the LIGNOLs were properly analyzed during the simulations. The determining property for the conformation preferred in aqueous solution was found to be the lowest energy in gas phase. The solvation effects on the LIGNOLs were also studied by quantum chemical calculations applying the COnductor-like Screening MOdel (COSMO). The hydration studies of the MD simulations showed that several of these LIGNOLs, produced from a renewable source, have a great potential of acting as chiral catalysts.
Reducing the contact time of droplet impact by active control of substrate motion (2018)

We report a method to reduce the contact time of a droplet impacting a superhydrophobic surface by typically 50%, which is achieved by controlling the substrate motion. In our method, the substrate motion is sinusoidal and triggered by a detection of the moment of impact with a piezoresistive force sensor which is fabricated on the substrate. This force sensor allows us to precisely move the substrate as the droplet comes into contact with it. We investigated the effect of the period of the substrate motion on the contact time and found that the most efficient reduction of the contact time was reached when moving the substrate with a period that is comparable to the spreading time of the droplet.
Experimental Study on Flexural Behavior of Reinforced Concrete Walls (2013)

Design codes prescribe equations for the ultimate state design of RC walls with flange walls as boundary elements. These codes consider part of the length of the flange wall as a width that will effectively resist lateral loads. However, wall damage and the accuracy of the effective width used in the calculations have not been sufficiently discussed. Therefore, a loading test is carried out at Yokohama National University on two 1/3 scale specimens in order to evaluate the strength, damage, energy dissipation, and behavior of RC structural walls in flexure. One specimen without flange walls and one with flange walls are tested. The strength and response of each specimen are described, and the prediction accuracy of the design flexural strengths given by design codes ACI, Eurocode, and AIJ are examined. Experimental strain data are used to describe the behavior of the flange wall in order to understand the mechanism and to confirm the accuracy of the effective width prescribed by the design codes in terms of tension and compression. The result of the experimental study reveals that design prescriptions given by ACI, Eurocode, and AIJ guidelines can conservatively estimate the flexural strength for RC walls without flanges, but they underestimate the flexural strength for flanged walls. This underestimation is due to a lack of knowledge of the mechanism that develops at the flange. It is not possible to determine a specific value for flexural effective width. However, according to the results of calculations, a portion larger than the width proposed by the aforementioned design codes serves to resist the stresses imposed by lateral loads. Therefore, it is confirmed that the flange width is underestimated by the design codes, and it increases with the imposed drift level. The stress distribution at the flange in the out-of-plane direction is found not to be uniform, a fact that is at odds with design assumptions.
Lipoic acid in animal models and clinical use in diabetic retinopathy (2013)

The diverse beneficial effects of ALA, many of which have only recently been uncovered, suggest that it acts by multiple mechanisms on oxidative stress parameters. Consequently, ALA supplementation is an achievable adjunct therapy to help prevent vision loss in diabetic patients. Finally, further research to better understand the mechanism of ALA will be useful for the development of more effective therapies in patients affected by DR.
ChemInform Abstract: Substituted Alkyne Synthesis under Nonbasic Conditions: Copper Carboxylate‐Mediated, Palladium‐Catalyzed Thioalkyne—Boronic Acid Cross‐Coupling. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Geophysics Dissertation Abstracts (2011)

Abstract Geophysics publishes abstracts of dissertations and titles of master’s theses both in print and online. Recent graduates are invited to submit their abstracts or titles by completing and submitting the appropriate form found at http://seg.org/dissertationabstracts. Abstracts and titles will be reviewed and accepted or rejected based on their relevance to the readers of Geophysics. Abstracts must be written in English and defended in 2009 or later.
Capacity of Coherent Frequency-Hop Spread-Spectrum Communications (2005)

The capacity of a coherent frequency-hopped (C-FH) spread-spectrum system is investigated, The channel comprises an M-ary phase-shift keying (M-PSK) modulator, a frequency hopper with phase-continuous carrier, the transmission medium, a nonideal phase-coherent frequency dehopper, an M-PSK demodulator, and a carrier tracking system. Additive white Gaussian noise is considered. The analysis focuses on the effect of imperfect recovery of the carrier phase on the demodulation process. The carrier tracking system includes a maximum likelihood estimator of the phase error and a first-order digital phase-lock loop. The phase error is modeled as a Markov process. An expression for the state transition probabilities of the phase error process is given. Using bounds on the entropy of a function of a Markov process, lower bounds to the capacity of C-FH channels are derived. The input symbols are assumed uniformly distributed and the encoding process independent of the frequency slot selected to send each symbol. Numerical results obtained for various values of M and of the number of frequency slots are presented.
Validation and Characterization Database Supporting Two-Phase 1+1D PEMFC Model Development (2011)

Abstract not Available.
Development of a production worthy copper CMP process (2002)

A chemical mechanical polishing (CMP) process for copper damascene structures has been developed and characterized on a second generation, multiple platen polishing tool. Several formulations of experimental copper slurries containing alumina abrasive particles were evaluated for their selectivity of copper to Ta, TaN and PETEOS films. The extent of copper dishing and oxide erosion of these slurries is investigated with various process parameters such as slurry flow rate, platen speed and wafer pressure. The amount of dishing and erosion is found to be largely dependent on process parameters as well as the slurry composition. It is shown that the extent of oxide erosion and copper dishing can be significantly reduced by using a two slurry copper polish process (one slurry to polish copper and another to polish barrier layers) in conjunction with an optical end-point detection system.
Dendritic cell vaccination and immune monitoring (2008)

We exploited dendritic cells (DC) to vaccinate melanoma patients. We recently demonstrated a statistical significant correlation between favorable clinical outcome and the presence of vaccine-related tumor antigen-specific T cells in delayed type hypersensitivity (DTH) skin biopsies. However, favorable clinical outcome is only observed in a minority of the treated patients. Therefore, it is obvious that current DC-based protocols need to be improved. For this reason, we study in small proof of principle trials the fate, interactions and effectiveness of the injected DC.
Supplementary Figure 5 from <i>De novo</i> Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation (2023)

Supplementary Figure 5 from &lt;i&gt;De novo&lt;/i&gt; Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation
Novel vacuum packaged 384×288 broadband bolometer FPA with enhanced absorption in 3-14μm wavelength (2017)

This paper reports on the development of a fully packaged focal plane array of broadband microbolometers. The detector makes use of a gold black thin film to expand its absorption range from 3 to 14 &mu;m. A low temperature packaging process was developed to minimize sintering of the gold black absorber during vacuum sealing of the bolometer array package. The gold black absorber was also laser trimmed to prevent lateral diffusion of heat and promote a better MTF. The resulting FPAs show a NETD lower than 25 mK at a frame rate of 50 Hz
Acinar Cell Carcinoma With Prominent Intraductal Growth Pattern (2009)

Acinar cell carcinoma of the pancreas is rare, accounting for less than 1% of carcinomas arising in the exocrine pancreas. Patients are typically between the fifth and seventh decade of life and show a 2:1 male predominance. Symptoms tend to be nonspecific, and approximately 50% of the patients have metastases at the time of presentation. There have been recent case reports of acinar cell carcinoma showing both intraductal and/or papillary patterns of growth that could potentially be mistaken for intraductal neoplasia. The cases reported up to date presented as solitary nodules. The authors describe the first case of acinar cell carcinoma with both intraductal and tubuloglandular growth diffusely involving the pancreas. In addition, the authors review the published cases reporting acinar cell carcinoma with intraductal and/or papillary growth patterns.
The Neuroscience Information Framework: A Data and Knowledge Environment for Neuroscience (2008)

With support from the Institutes and Centers forming the NIH Blueprint for Neuroscience Research, we have designed and implemented a new initiative for integrating access to and use of Web-based neuroscience resources: the Neuroscience Information Framework. The Framework arises from the expressed need of the neuroscience community for neuroinformatic tools and resources to aid scientific inquiry, builds upon prior development of neuroinformatics by the Human Brain Project and others, and directly derives from the Society for Neuroscience's Neuroscience Database Gateway. Partnered with the Society, its Neuroinformatics Committee, and volunteer consultant-collaborators, our multi-site consortium has developed: (1) a comprehensive, dynamic, inventory of Web-accessible neuroscience resources, (2) an extended and integrated terminology describing resources and contents, and (3) a framework accepting and aiding concept-based queries. Evolving instantiations of the Framework may be viewed at http://nif.nih.gov , http://neurogateway.org , and other sites as they come on line.
Mise en oeuvre d'une commmande temps réel de transmission hybride sur banc d'essai moteur (2004)

2ème Congrès Européen des Alternatives énergétiques dans l'automobile, POITIERS, FRANCE, 07-/04/2004 - 08/04/2004
In-Silico Algorithms for the Screening of Possible microRNA Binding Sites and Their Interactions (2013)

MicroRNAs (miRNAs) comprise a recently discovered class of small, non-coding RNA molecules of 21-25 nucleotides in length that regulate the gene expression by base-pairing with the transcripts of their targets i.e. protein-coding genes, leading to down-regulation or repression of the target genes. However, target gene activation has also been described. miRNAs are involved in diverse regulatory pathways, including control of developmental timing, apoptosis, cell proliferation, cell differentiation, modulation of immune response to macrophages, and organ development and are associated with many diseases, such as cancer. Computational prediction of miRNA targets is much more challenging in animals than in plants, because animal miRNAs often perform imperfect base-pairing with their target sites, unlike plant miRNAs which almost always bind their targets with near perfect complementarity. In the past years, a large number of target prediction programs and databases on experimentally validated information have been developed for animal miRNAs to fulfil the need of experimental scientists conducting miRNA research. In this review we first succinctly describe the prediction criteria (rules or principles) adapted by prediction algorithms to generate possible miRNA binding site interactions and introduce most relevant algorithms, and databases. We then summarize their applications with the help of some previously published studies. We further provide experimentally validated functional binding sites outside 3'-UTR region of target mRNAs and the resources which offer such predictions. Finally, the issue of experimental validation of miRNA binding sites will be briefly discussed.