gebhart/patrepeval huggingface dataset:
Reactions of 2-methylene-1,3-cyclopentanedione with electron-rich alkenes (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of 2-methylene-1,3-cyclopentanedione with electron-rich alkenesWilliam H. Bunnelle and Leslie Ann MeyerCite this: J. Org. Chem. 1988, 53, 17, 4038–4042Publication Date (Print):August 1, 1988Publication History Published online1 May 2002Published inissue 1 August 1988https://pubs.acs.org/doi/10.1021/jo00252a029https://doi.org/10.1021/jo00252a029research-articleACS PublicationsRequest reuse permissionsArticle Views352Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
RETROFIT OF OUTDOOR MEDIUM VOLTAGE CIRCUIT BREAKER WITH ECO-FRIENDLY GAS TO REPLACE SF 6 (2021)

In this paper, some stages of the assessment for the replacement of sulphur hexafluoride (SF6) with the fluoronitrile (C4F7N) and carbon dioxide (CO2) mixture in a medium-voltage vacuum interrupting circuit breaker, HORIZON 38kV Outdoor Circuit Breaker manufactured by BRUSH Switchgear, is presented. The circuit breaker volume is filled with the fluorinated gaseous mixture and tested for both basic lightning impulse and short duration power frequency withstand following the recommendations of the relevant standards. It should be noted that some crucial modifications were made to the design to suit the new gas mixture under test. Prior to the test campaign, a series of electric field computations were performed, using a commercial finite element method (FEM) software package, to ensure that a safety margin from the critical electric field values is maintained and identify areas of excessive electric field stress that can be potentially improved. Data on the properties of the fluoronitrile compound and its mixture with CO2 is presented. Initial test results demonstrate that the more environmentally friendly gaseous mixture of 20% fluoronitrile content offers satisfactory insulation withstand performance, indicating its suitability from an insulation performance perspective.
ChemInform Abstract: Basics and Prospective of Magnetic Heusler Compounds (2015)

Abstract Review: 61 refs.
Modeling behavior in a network using event logs (2023)

A framework is provided for modeling the activity surrounding user credentials and/or machine level activity on a computer network using computer event logs by viewing the logs attributed to each user as a multivariate data stream. The methodology performs well in detecting compromised user credentials at a very low false positive rate. Such a methodology may detect both users of compromised credentials by external actors and otherwise authorized users who have begun engaging in malicious activity.
High-Performance Liquid Chromatography of Amphibian Peptides. Selectivity Changes Induced by pH (1984)

Abstract The effect of pH on the retention behavior under reversed- phase liquid chromatography conditions of a series of peptides was examined. Isocratic conditions were used with either methanol or acetonitrile as organic modifiers. The intrinsic hydrophobicity of the peptides was altered by changes in the pH of the eluent mixture. Increased retention at pH 7 relative to pH 4 was correlated with the presence of a histidine residue in a hydrophobic environment. An experimental parameter, αpH, was defined as the positive quotient of capacity factors at pH 4 and pH 7 for a given eluent. These αpH values are interpreted as reflecting changes in peptide hydrophobicity introduced by variations in solvent and pH. Identical αpH values were obtained for homologous peptides, particularly histidine containing peptides. This approach to selectivity effects yielded diagnostic conditions for the analysis of bombesin, a peptide touted as a potential marker for human small-cell lung carcinoma.
Integration and Testing of the Hybrid Gamma Cameras for AdaptiSPECT-C (2021)

Recent advances in scintillation light sensors are enabling new designs for single-photon-emission computed tomography (SPECT) cameras for use in nuclear medicine, achieving higher sensitivity and spatial resolution than previously possible. One such camera is AdaptiSPECT-C: a new stationary and adaptive SPECT system designed for clinical whole-brain imaging. It employs a 24-stationary-camera configuration in conjunction with multi-pinhole apertures, significantly increasing its overall sensitivity to gamma radiation. Each of the five pinholes assigned to a camera can actively select among several different aperture diameters and a shuttered state; the latter function enabling the acquisition of both non-multiplexed and multiplexed image data in a single session.Each 18-cm-square camera in AdaptiSPECT-C houses 25 photomultiplier tubes (PMTs) and 24 multi-pixel photon counters (MPPCs). This combination results in a camera that achieves uniformly high spatial resolution across the entire crystal area. In this work we present the combined MPPC/PMT hybrid camera design, prioritizing modularity and space efficiency. We also cover schematics for the front-end electronics and their hardware integration, specifically highlighting initial test pulses from the two sensor types. The results of said testing show promise for the eventual merging of hybrid signal information into a comprehensive dataset during real world image acquisitions. Finally, we present preliminary calibration results and compare to predictions based on light-transport simulations.
Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells (2017)

Resveratrol (RES), a polyphenol found in natural foods, displays anti-oxidant, anti-inflammatory and anti-proliferative properties potentially beneficial in cancers, in particular in the prevention of tumor growth. However, the rapid metabolism of resveratrol strongly limits its bioavailability. The molecular mechanisms sustaining the potential biological activity of low doses of resveratrol has not been extensively studied and, thus, needs better characterization. Here, we show that resveratrol (10 µM, 48 hr) induces both a cell growth arrest and a metabolic reprogramming in colon cancer cells. Resveratrol modifies the lipidomic profile, increases oxidative capacities and decreases glycolysis, in association with a decreased pentose phosphate activity and an increased ATP production. Resveratrol targets the pyruvate dehydrogenase (PDH) complex, a key mitochondrial gatekeeper of energy metabolism, leading to an enhanced PDH activity. Calcium chelation, as well as the blockade of the mitochondrial calcium uniport, prevents the resveratrol-induced augmentation in oxidative capacities and the increased PDH activity suggesting that calcium might play a role in the metabolic shift. We further demonstrate that the inhibition of the CamKKB or the downstream AMPK pathway partly abolished the resveratrol-induced increase of glucose oxidation. This suggests that resveratrol might improve the oxidative capacities of cancer cells through the CamKKB/AMPK pathway.
Scalable fault management for mobile networks beyond 3G (2005)

The development of future releases of third generation and fourth generation cellular network shows a clear indications that today's ATM-based radio access network (RAN) was replaced by an IP-based RAN particularly for reducing the cost compared to today's RANs. Managing an IP-based RAN with SNMP is a challenge, particularly concerning scalability. Already existing solutions for delegating management functions to managed nodes can achieve the required scalability, but they come with a big overhead of resource consumption and complexity. This paper presents a lean solution for health checking of managed nodes that achieves this goal by restricting itself to this purpose. The CHECK MIB module serves for remote configuration of heath check actions to be performed at a managed node and for retrieving health check results. Resource consumption is very low compared to already existing, more general technologies. Health checks can be specified easily by setting a very small number of objects and the implementation of the MIB module is lightweight.
Anatomic localization of dendritic cells subsets and plasmacytoid-like Th1 T lymphocytes in rheumatoid synovium: correlation with selective chemokine expression (2002)

Vascular changes are consistent early findings in patients with SSc and often precede the development of fibrosis. Despite a significant reduction in the capillary density, there is paradoxically no sufficient angiogenesis in the skin of SSc patients. By using a pO 2 histograph, we showed that low pO 2 values are overt in involved skin of patients with SSc. In vitro, real-time PCR revealed a 3.7-fold upregulation of the potent angiogenic growth factor VEGF in SSc fibroblasts after hypoxic exposure compared to normoxic controls. In situ hybridization for VEGF in skin biopsies of patients with SSc showed an overexpression of VEGF mRNA by fibroblasts and mononuclear infiltrates, whereas its expression was limited to keratinocytes in healthy control biopsies. In contrast to the SSc skin, HIF-1 alpha protein was found to be coexpressed with VEGF in healthy skin samples, indicating that the constitutive VEGF synthesis in the skin is driven by this transcription factor. Additionally, we showed that the lack of angiogenesis in SSc is not due to a reduced bioavailability of the overexpressed VEGF, since the VEGF receptors Flk-1 and Flt-1 were found to be expressed on endothelial cells of patients with SSc, but not in healthy controls, and since SSc patients had severely elevated serum levels of VEGF compared to healthy controls. Despite the enhanced levels of VEGF, serum samples of SSc patients did not induce angiogenesis in the vivo chorion allantois membrane assay, indicating that the proangiogenic effects of VEGF may be outweighed by angiostatic factors. The hypothesis that VEGF synthesis has to be above an individual threshold in SSc patients to induce angiogenesis was further strengthened by the finding that patients without fingertip ulcers had significantly higher levels than patients with fingertip ulcers. Interestingly, the angiostatic factor endostatin was elevated in a subset of patients and thus may counteract directly the bio-logic effects of VEGF in SSc patients. Serum levels of VEGF were also correlated significantly with disease severity parameters including antitopoisomerase antibodies. These results suggest that therapeutic application of VEGF by either gene transfer or as a recombinant protein might be a novel option in SSc.
Finite Element Approach for Reactive Microfluidic Devices (1998)

We report a finite element method (FEM) based model for simulating microfluidic devices with chemical reactions. The simulation approach incorporates a general mesh generation procedure, which allows us to explore different application-oriented designs of microfluidic devices. Simulations, which have been validated by experiments, are used to characterize temperature and species profiles of a Tshaped microreactor. Predicted results capture the observed complex temperature behavior arising from the heat generation of catalytic reactions. Simulation tools developed in this work are demonstrated to be useful in designing a silicon-membrane based microreactor with improved heat transfer characteristics.
Characteristics of 4/2 Switched Reluctance Motor for a high speed drive by the excitation angle (2009)

Recent interests in reluctance torque assisted motors as high drives, has spurred a great deal of research into their development and practical uses. switched reluctance motor (SRM) is one of them. This paper copes with it. It has simple, and has wide range torque - speed characteristics. Despite the fact that it has many attractive features, it is slow to introduce the motor to many applications because of the difficulty to control. For example, it has the nonlinear inductance characteristics. In addition, the current build-up time is not enough in a high speed region. Hence, it cannot satisfy the motor ability. Therefore, this paper deals with the characteristics of 4/2 SRM (with four stator poles and two rotor poles) by the excitation timing. First, the model is illustrated. Second, the dynamic simulation model with the nonlinear characteristics is defined. Third, the torque-speed characteristics by the excitation angle are discussed from experimental and simulated aspects. Finally, this paper concludes that the excitation angles should be changed at the motor speed.
Stereoisomers of Cyclic Urea HIV-1 Protease Inhibitors:  Synthesis and Binding Affinities (1998)

We have synthesized stereoisomers of cyclic urea HIV-1 protease inhibitors to study the effect of varying configurations on binding affinities. Four different synthetic approaches were used to prepare the desired cyclic urea stereoisomers. The original cyclic urea synthesis using amino acid starting materials was used to prepare three isomers. Three additional isomers were prepared by synthetic routes utilizing L-tartaric acid and D-sorbitol as chiral starting materials. A stereoselective hydroxyl inversion of the cyclic urea trans-diol was used to prepare three additional isomers. In all 9 of the 10 possible cyclic urea stereoisomers were prepared, and their binding affinities are described.
751 Interaction Force analysis between a Machine and Soil by DEM (Distinct Element Method) (2012)

In design of machines that run on non-pavement road or soft ground, it is important to analyze the interaction between a machine and soil. When the machine runs, the machine causes various phenomena such as compression and shear action and so on. Each phenomenon makes the comprehensive movement of the soil complex. Recently, the technique of distinct element method (DEM) has been invented as computer technology developed. We can analyze the movement of the soil quickly by DEM. Therefore, we were able to get way to describe outline of the movement. However, we were not able to make high accurate model yet, because DEM has the problem that the order of the particle radius cannot be made same as that of the real soil. In this paper, we determine particle parameter to obtain the nearer interaction force to real. For this, we examine the effect which change of particle parameter in simulation gives to the interaction force. The result shows that the interaction force with 2.5mm radius and Young's module of 1000MPa in simulation is close to that in experiment. The force with 3.0mm radius is almost same as that with 2.5mm radius. Analytical time with the former is shorter than one with the latter. In my conclusion, 3.0mm radius in the simulation is the best way to understand the movement of the real soil.
Synthesis of 20-<i>N</i>-Methylpurpuramine E, an Antitubercural Metabolite from <i>Pseudoceratina</i> sponge (2010)

0-N-Methylpurpuramine E has been successfully synthesized in 2 steps in good yield from readily available starting materials. Structural elucidation has been confirmed through direct comparison with spectroscopic data of isolated natural product.20-N-Methylpurpuramine E has been shown to have MIC = 5 μg mL-1 against Mycobacterium bovis.
Holographic Antenna with Slotted Yagi Array Antenna as Surface Wave Launcher (2019)

In this paper, the holographic antenna with 4 elements of slotted Yagi array antenna as surface wave launcher is proposed to generate the plane wave holographic pattern within the small size of the antenna. The type of the feeder antenna is chosen to the slotted Yagi antenna for mode which radiates uni-directionally. The main radiator of the feeder antenna is modified to reduce mutual coupling. By arraying 4 elements of the feed antennas, they are able to generate plane wave just in front of themselves. The proposed holographic antenna with 12 metal strips is designed on the substrate of 24.25 x70 mm2 and analyzed the characteristics of the gain and the radiation efficiency.
Continuous Transforming Growth Factor β 1 Secretion by Cell-Mediated Gene Therapy Maintains Chondrocyte Redifferentiation (2005)

One of the most important factors in the production of cartilage is transforming growth factor beta1 (TGF-beta1). To obtain sustained release of TGF-beta1, a cell-mediated gene therapy technique was introduced. We infected chondrocytes with a retroviral vector carrying the TGF-beta1 gene. The single clone derivative showed sustained TGF-beta1 secretion. It also showed constitutive type II collagen expression. Whereas the TGF-beta1 protein itself is unable to induce formation of cartilage in vivo, human chondrocytes engineered to express a retroviral vector encoding TGF-beta1 showed cartilage formation in vivo when cells were injected into nude mice intradermally. These data suggest that cell-mediated gene therapy using TGF-beta1 as a transgene would be a promising treatment for osteoarthritis.
Supplemental Figure Legends from Obesity Contributes to Ovarian Cancer Metastatic Success through Increased Lipogenesis, Enhanced Vascularity, and Decreased Infiltration of M1 Macrophages (2023)

&lt;p&gt;Legends for Supplemental Figures S1-S4&lt;/p&gt;
Microendoscopic discectomy for recurrent disc herniations (2003)

Microendoscopic discectomy for recurrent disc herniation can be safely performed without an increase in surgery related morbidity.
Enhanced High-Harmonic Generation Using 25 fs Laser Pulses (1996)

We present experimental and theoretical results on high-harmonic generation in noble gases using an 805 nm, 25 fs, titanium-doped sapphire laser. The harmonic energies observed are unexpectedly high when compared with experimental and theoretical results to date for longer excitation pulses. We observe that the efficiency of harmonic production is highest for shorter pulses. Furthermore, the wavelength of the harmonics can be tuned by adjusting the sign of the chirp of the excitation pulse, demonstrating a tunable, ultrashort-pulse, $&lt;25\mathrm{fs}$ soft-x-ray source.
Benzofuran Derivatives as Potent, Orally Active S1P1 Receptor Agonists: A Preclinical Lead Molecule for MS (2010)

We have discovered novel benzofuran-based S1P1 agonists with excellent in vitro potency and selectivity. 1-((4-(5-Benzylbenzofuran-2-yl)-3-fluorophenyl)methyl) azetidine-3-carboxylic acid (18) is a potent S1P1 agonist with >1000× selectivity over S1P3. It demonstrated a good in vitro ADME profile and excellent oral bioavailability across species. Dosed orally at 0.3 mg/kg, 18 significantly reduced blood lymphocyte counts 24 h postdose and demonstrated efficacy in a mouse EAE model of relapsing MS.
A Novel DC Ice-melting Equipment Based on Modular Multilevel Cascade Converter (2013)

In view of the problems such as huge bulk,harmonic pollution,and complicated switching with the currently widely used ice-melting equipment based on the state var compensator(SVC),a new design based on the modular multilevel cascade converter is proposed.The double-star bridge-cells modular multilevel cascade converter(DSBC-MMC)discussed in this paper is a combination of H-bridge static synchronous compensator(STATCOM)and half bridge modular multilevel converter(MMC),which can be used as a reactive power compensator and high voltage DC source.Thus it is suitable for DC ice-melting application.A control method which takes into account both the DC ice-melting and reactive power compensation is proposed.The simulation performed has verified the effectiveness of the solution and control method proposed.
High-efficiency carbon dioxide capture using an algal amino acid salt solution (2023)

This study developed a novel, high-efficiency, and bio-based CO2 absorbent – microalgal amino acid salt solution (MAASS). The MAASS was prepared by hydrolyzing microalgal biomass with potassium hydroxide. Alanine, glutamic acid, glycine, aspartic acid, leucine, lysine, and proline are the primary amino acids in the MAASS with a total amino acid concentration of 0.592 mol/L. The absorption and desorption results on a synthetic flue gas with 10 %(v/v) CO2 and 90 %(v/v) air showed that the MAASS had an absorption capacity of 1.27 mol CO2/mol amine, which is 3.4 and 3.1 times higher than monoethanolamine (MEA) and the reported pure amino acid salt solution, respectively. The MAASS was regenerable, showing no signs of deterioration in the absorption capacity after eight consecutive absorption and desorption cycles. The mass and energy balance analysis concluded that combining algal cultivation and MAASS absorption would lead to a technically feasible and environmentally friendly CO2 capture technology.
Droplet generating device for droplet-based μTAS using electro-conjugate fluid (2017)

Droplet-based μTAS, which carries out biochemical inspection and synthesis by handling samples as droplets on a single chip, has been attracting attentions in recent years. Although miniaturization of a chip is progressed, there are some problems in miniaturization of a whole system because of the necessity to connect syringe pumps to the chip. Thus, this study aims to realize a novel droplets generating device for droplet-based μTAS using electro-conjugate fluid (ECF). The ECF is a dielectric liquid generating a powerful flow when subjected to high DC voltage. The ECF flow generation allows us to realize a tiny hydraulic power source. Using the ECF flow, we can develop a droplet generating device for droplet-based μTAS by placing minute electrode pairs in flow channels. The device contains two channels filled with the ECF, which are dispersed and continuous phases meeting at a T-junction. When a sample in the dispersed phase is injected by the ECF flow to the continuous phase at T-junction, droplets are generated by shearing force between the two phases. We conducted droplet generating experiment and confirmed that droplets are successfully generated when the flow rate of the continuous phase is between 90 and 360 mm3 s−1, and the flow rate of the dispersed phase is between 10 and 40 mm3 s−1. We also confirmed that the droplet diameter and the droplet production rate are controllable by tuning the applied voltage to the electrode pairs.
31.2: Invited Paper: High Efficiency Red and Green InP‐Quantum Dot Light‐Emitting Diodes (2021)

We demonstrate high‐efficiency red and green indium phosphide (InP) quantum dot light‐emitting diodes (QLEDs) comprising low mobility electron transport layer and high mobility hole transport layer with deep HOMO level. Red and green InP‐QLEDs show maximum external quantum efficiency of 21.8% and 13.5%, respectively, and high device stability.