gebhart/patrepeval huggingface dataset:
Ethanol-induced hypothermia in rats is antagonized by dexamethasone (1997)

The effect of dexamethasone on ethanol-induced hypothermia was investigated in 3.5-month old male Wistar rats (N = 10 animals per group). The animals were pretreated with dexamethasone (2.0 mg/kg, i.p.; volume of injection = 1 ml/kg) 15 min before ethanol administration (2.0, 3.0 and 4.0 g/kg, i.p.; 20% w/v) and the colon temperature was monitored with a digital thermometer 30, 60 and 90 min after ethanol administration. Ethanol treatment produced dose-dependent hypothermia throughout the experiment (-1.84 +/- 0.10, -2.79 +/- 0.09 and -3.79 +/- 0.15 degrees C for 2.0, 3.0 and 4.0 g/kg ethanol, respectively, 30 min after ethanol) but only the effects of 2.0 and 3.0 g/kg ethanol were significantly antagonized (-0.57 +/- 0.09 and -1.25 +/- 0.10, respectively, 30 min after ethanol) by pretreatment with dexamethasone (ANOVA, P < 0.05). These results are in agreement with data from the literature on the rapid antagonism by glucocorticoids of other effects of ethanol. The antagonism was obtained after a short period of time, suggesting that the effect of dexamethasone is different from the classical actions of corticosteroids.
Genomic and Proteomic Analysis of Patients with Reoccurring Discrete Subaortic Stenosis (2023)

Abstract Discrete subaortic stenosis (DSS) is a pediatric condition in which a fibrotic membrane forms within the left ventricular outflow track. The fibrotic membrane is removed surgically; however, there is a high rate of reoccurrence which requires a second surgery. There are currently no tools available to predict the risk of reoccurrence in DSS patients, a limitation addressed by this study. In this study, we analyzed resected fibrotic membranes for DSS patients at the time of first surgery for non-recurrent and recurrent patients, and at the time of second surgery for recurrent patients. RNA-sequencing was conducted to obtain a global screen of changes in RNA expression while mass spectrometry was used to obtain a global screen of changes in protein expression. The results from the RNA-sequencing and mass spectrometry provide valuable insight into genes and the proteins that are differentially regulated in recurrent vs non-recurrent DSS patients.
50.3: Low Power, High Image Quality Color Reflective LCDs Realized by Memory‐in‐Pixel Technology and Optical Optimization Using Newly‐Developed Scattering Layer (2013)

Abstract Reflective color LCDs with high image quality, which have very low power consumption when displaying still images and can also display moving pictures, have been developed. Two key technologies are Memory‐in‐Pixel (MIP) fabrication using LTPS technology, and another is optical property optimization by adopting a newly‐developed scattering layer.
Thermodynamic and Economic Assessment of Oxy-Combustion CCS System Applied to Gas Turbine-Driven Compressor Stations (2010)

Government policies currently in place or in development will require the reduction of greenhouse gas emissions from industry, including gas transmission systems. Most of the natural gas transmission systems are powered by gas turbines of sizes up to 30 MW per unit. A typical gas turbine of this size can emit 6 ktonnes of CO2 per MW-year, equivalent to about 180 ktonnes per year. Reduction in greenhouse gas emissions can be accomplished through post-combustion systems (separation of CO2 from flue gases through chemical absorption, physical adsorption, membrane or cryogenic systems) or through oxy-fuel combustion, where fuel is combusted in pure O2 leading to sequestration of CO2 by compression and dehydration of the exhaust gases. The purpose of the current work is to explore the application of the latter concept, simplify and enhance the cycle, and to provide an economic valuation of the cost per tonne of CO2 abated. Innovations explored for enhancement include elimination of excess power production, simplification of capital equipment requirements, and optimization of the power to the booster produced from the gas turbine and steam turbine. The paper presents various innovation options arrived at, detailed thermodynamic parameters, and a cost and economic evaluation of these options. Particular emphasis was placed on the application of this technology to a typical compressor station on a natural gas transmission system as this application is vastly different than a typical power plant contemplating or employing carbon capture and storage (CCS) systems, most notably from the small power size, the remote location, and the self-containment perspectives.
Colloquium Fundamentale SS 2015 - Aktuelle und zukünftige Anwendungen von Licht in der Medizin (2015)

Aktuelle und zukünftige Anwendungen von Licht in der Medizin Prof. Dr. med. Norbert Gretz, sprach in einem weiteren Vortrag des Colloquium Fundamentale „Spektrum des Lichts“, über das "Licht in der Medizin". Welche Rolle spielt das Licht in der Medizin? Welche Anwendungen gibt es aktuell und wie sieht es in der Zukunft aus? Sind diese neuen Methoden zuverlässig und vertrauenswürdig? Diesen und weiteren Fragen ging der Direktor des Instituts für Medizintechnologie und des Zentrums für Medizinische Forschung der Medizinischen Fakultät Mannheim (Universität Heidelberg) in seinem Vortrag nach. Die Veranstaltung fand am 18. Juni 2015 im Rahmen des Colloquium Fundamentale am ZAK | Zentrum für Angewandte Kulturwissenschaft und Studium Generale statt. Weitere Informationen: http://www.zak.kit.edu/cf_ss15.php
Computational Prediction of Boron-Based MAX Phases and MXene Derivatives (2020)

Conventional MAX phases (M is an early transition metal, A represents a p-block element or Cd, and X is carbon or nitrogen) have so far been limited to carbides and/or nitrides. In the present work, a series of stable layered ternary borides were predicted by combining variable-composition evolutionary structure search and first-principles calculations. The predicted Hf2InB2, Hf2SnB2, Zr2TlB2, Zr2PbB2, and Zr2InB2 show a Ti2InB2 type of structure (space group P6̅m2, No. 187, Nat. Commun. 2019, 10, 2284), and the structures of Hf3PB4 and Zr3CdB4 share the same space group with Ti2InB2 but belong to a new structure type. These two structural prototypes, M2AB2 and M3AB4 (M is Zr or Hf), have the composition and local structures of MAB phases, but inherit a hexagonal symmetry of MAX phases. Moreover, Hf2BiB and Hf2PbB exhibit a typical structure of conventional MAX phases (Mn+1AXn, space group P63/mmc, No. 194). These findings suggest that boron-based ternary compounds may be a new platform of MAX phases. The functionalized two-dimensional (2D) borides derived from the predicted ternary phases are calculated to be with improved mechanical flexibility and adjustable electronic properties relative to the parent ones. In particular, the 2D Hf2B2T2 and Zr2B2T2 (T = F, Cl) can transform from metal to semiconductor or semimetal under appropriate compressive biaxial strains. Moreover, the 2D Zr2B2 exhibits a high theoretical lithium-ion (Li+) storage capacity and low Li+ migration energy barriers. These novel properties render 2D boron-based materials promising candidates for applications in flexible electronic devices and Li+ battery anode materials.
Soluble, Highly Conjugated Polyenes via the Molybdenum-Catalyzed Copolymerization of Acetylene and Diethyl Dipropargylmalonate (1996)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTSoluble, Highly Conjugated Polyenes via the Molybdenum-Catalyzed Copolymerization of Acetylene and Diethyl DipropargylmalonateFlorian J. Schattenmann and Richard R. SchrockView Author Information Department of Chemistry, 6-331, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 Cite this: Macromolecules 1996, 29, 27, 8990–8991Publication Date (Web):December 30, 1996Publication History Received25 July 1996Revised31 October 1996Published online30 December 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/ma9611026https://doi.org/10.1021/ma9611026rapid-communicationACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views315Altmetric-Citations54LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Aromatic compounds,Copolymers,Hydrocarbons,Physical and chemical properties,Polymers Get e-Alerts
Evaluation of harmonized alert sensing technology (HASTE) for a hemodynamic monitoring during hemodialysis (2003)

血液透析療法施行中における急激な血圧変化を早期に発見するための手段として, 日本コーリン社製生体情報モニタ 「Moneo BP-88si) に搭載されている循環モニタリング機能 (harmonized alert sensing technology; HASTE) の有効性を検討した. HASTEとは, 定期的な非観血式血圧測定 (non-invasive blood pressure; NIBP) と, 連続する心電図 (ECG) およびプレシスモグラフの波形情報から, 推定収縮期血圧 (estimated systolic blood pressure; Esys) を連続的に監視し, 急激な循環動態の変化を検知した場合, 自動的にNlBP測定を開始 (HASTEトリガ機能) するものである.今回の評価では当院入院患者5例を対象とし, HASTEによるEsysと, 観血式収縮期血圧 (invasive systolic blood pressure; Isys) を比較検討することによりその精度を評価した. その結果, EsysとIsysには強い相関関係が認められた (r=0.81±0.07). また, Isysの血圧変化を基準としたHASTEトリガの起動率を調べたところ, sensitivity 85.7%, specificity 84.6%であった. さらに, NIBP測定点からHASTEトリガ作動点までのIsysとEsysのBP変化率を調べたところ, 両者間において有意な正の相関が認められた (r=0.62, p<0.01). これらの結果から, HASTEは血液透析中の急激な血圧変化を早期に発見するための手段として有効であると思われる.
The Effect of Nonporous PTFE-Covered Stents on Intimal Hyperplasia following Balloon Arterial Injury in Minipigs (1998)

Purpose: To report an experimental study investigating the ability of nonporous polytetrafluoroethylene (PTFE) covering on a metallic stent to retard the development of neointimal hyperplasia (NIH). Methods: Three groups of Hanford miniature swine underwent standardized balloon injury to both external iliac arteries. Group I animals (control) received balloon injuries only. Group II had the site of balloon injury supported by a properly sized, balloon-expandable Palmaz stent placed directly over the injury site. Group III animals received a Palmaz stent covered with PTFE graft. All animals underwent arteriography immediately after intervention and again prior to sacrifice and specimen harvest at 4 weeks. The specimens were examined grossly and histologically at the proximal, middle, and distal segments for NIH development. Results: Uncovered stents developed significantly more NIH (p &lt; 0.0001) and greater luminal narrowing (p &lt; 0.001) than the controls. PTFE-covered stents (group III) exhibited less NIH (p &lt; 0.001) and luminal reduction (p &lt; 0.01) than bare stents (group II) at the middle portion of the stent-graft, but the PTFE cover had no effect on NIH and lumen reduction at the proximal or distal ends of the prosthesis. Conclusions: PTFE-covered stents retarded NIH at 4 weeks, but only at the midportion of the devices; the covering did not prevent neointimal pannus ingrowth at the proximal and distal ends.
Correction: Adipic acid production from lignin (2022)

Correction for ‘Adipic acid production from lignin’ by Derek R. Vardon et al. , Energy Environ. Sci. , 2015, 8 , 617–628, https://doi.org/10.1039/C4EE03230F.
Sensors, Sampling, and Simulation for Process Control (2011)

Foreword. Organizing Committee. Editors. Sensors, Sampling, and Simulation for Process Control. Liquid Metal Sensing and Online Measurement. In-Situ Sensors for Liquid Metal Quality (R. Guthrie, and M. Isac). Sensors for On-Line Monitoring of Molten Metal Quality (J. Fergus). Development of an Aqueous Particle Sensor (APSIII) System as a Research Tool for Studying the Behavior of Inclusions in Water Models of Tundish Operations (M. Isac, A. Chakraborty, L. Calzado, and R. Guthrie). The Development of a Sensor to Determine the Direction of Velocity in Liquid Aluminum (M. Sukhram, and S. Argyropoulos). New Sensors for the Velocity Measurement in Liquid Metal Processes (K. Timmel, S. Eckert, T. Wondrak, F. Stefani, and G. Gerbeth). Measurement of Molten Steel Surface Velocity with SVC and Nail Dipping during Continuous Casting Process (J. Sengupta, R. Liu, D. Crosbie, S. Chung, M. Trinh, and B. Thomas). Measurement of Transient Meniscus Flow in Steel Continuous Casters and Effect of Electromagnetic Braking (S. Cho, H. Lee, S. Kim, R. Chaudhary, B. Thomas, D. Lee, Y. Kim, W. Choi, S. Kim, and H. Kim). Temperature-Related Process Monitoring Systems. Dynamic Run-Out Table Cooling Simulator and Temperature Controllers (N. Pethe, K. Zheng, D. Huin, C. Moretto, and E. Poliak). Implementation of a Real-time Model-based Spray-cooling Control System for Steel Continuous Casting (B. Petrus, K. Zheng, X. Zhou, B. Thomas, J. Bentsman, and R. O'Malley). Measurement of the Solidification Front inside a Metallurgical Reactor (C. Bertrand, M. Marois, M. Desuets, and G. Soucy). Inverse Prediction and Control of the Bank Thickness in High Temperature Metallurgical Reactors (M. LeBreux, M. Desuets, and M. Lacroix). Online Imaging Pyrometer for Laser Deposition Processing (J. Craig, T. Wakeman, R. Grylls, and J. Bullen). Optimization of Continuous Hot Dipped Galvanization Lines through the Addition of a Hot Coating Weight Sensor (C. Burnett, and A. Quick). Monitoring of Meniscus Thermal Phenomena with Thermocouples in Continuous Casting of Steel (B. Thomas, M. Wells, andD. Li). Implementation of Temperature and Strain Micro-Sensors into a Casting Mold Surface (B. Thomas, and M. Okelman). Skelp Temperature Profile Control during Laminar Cooling using Genetic Algorithms (B. Binesh, J. Wiskel, A. Ben-Zvi, and H. Henein). Steel Processing: Online Sensors. Comprehensive Integrated Level 2 Melt Shop Management Systems (J. Middleton). Analysis of the Transient Phenomena during Steel Continuous Casting through the On-line Detection Data (L. Zhang, A. Dong, and S. Li). Author Index. Subject Index.
Ceria Nanoparticles Decrease UVA-Induced Fibroblast Death Through Cell Redox Regulation Leading to Cell Survival, Migration and Proliferation (2020)

Exposure to ultraviolet radiation is a major contributor to premature skin aging and carcinogenesis, which is mainly driven by overproduction of reactive oxygen species (ROS). There is growing interest for research on new strategies that address photoaging prevention, such as the use of nanomaterials. Cerium oxide nanoparticles (nanoceria) show enzyme-like activity in scavenging ROS. Herein, our goal was to study whether under ultraviolet A rays (UVA)-induced oxidative redox imbalance, a low dose of nanoceria induces protective effects on cell survival, migration, and proliferation. Fibroblasts cells (L929) were pretreated with nanoceria (100 nM) and exposed to UVA radiation. Pretreatment of cells with nanoceria showed negligible cytotoxicity and protected cells from UVA-induced death. Nanoceria also inhibited ROS production immediately after irradiation and for up to 48 h and restored the superoxide dismutase (SOD) activity and GSH level. Additionally, the nanoceria pretreatment prevented apoptosis by decreasing Caspase 3/7 levels and the loss of mitochondrial membrane potential. Nanoceria significantly improved the cell survival migration and increased proliferation, over a 5 days period, as compared with UVA-irradiated cells, in wound healing assay. Furthermore, it was observed that nanoceria decreased cellular aging and ERK 1/2 phosphorylation. Our study suggests that nanoceria might be a potential ally to endogenous, antioxidant enzymes, and enhancing the redox potentials to fight against UVA-induced photodamage and consequently modulating the cells survival, migration, and proliferation.
5G enabled cooperative collision avoidance: System design and field test (2017)

We explore the feasibility of 5G for enhancing cooperative automated driving. A V2X solution for enhancing road safety through connected cars based on 5G radio technology is shown. Based on a flexible, re-configurable software defined radio test-bed, we examine the benefit of ultra low latency and high reliability (URLLC) profile for enhanced emergency brake maneuver. This use case reveals the advantages and additional requirements of using 5G for automated emergency braking based on vehicle-to-vehicle communication. We analyze the impact of communication latency and reliability on the maneuver performance and associated safety aspect. The results provide insights into the joint-design of a V2X communication system for enhancing road safety through cooperative automated driving.
Continuously tunable 116 μs optical delay of 100 Gbit/s DQPSK and 50 Gbit/s DPSK signals using wavelength conversion and chromatic dispersion (2010)

We demonstrate a variable optical delay element that uses tunable wavelength conversion and phase conjugation in highly nonlinear fiber and uses chromatic dispersion in dispersion-compensating fiber. A continuous delay of up to 1.16mus, equaling a >110,000 time-delay bit-rate product for 100 Gbit/s non-return-to-zero differential quadrature phase-shift-keying (NRZ-DQSPK) and >55,000 for 50 Gbit/s NRZ differential phase-shift-keying (NRZ-DPSK) modulation formats, is demonstrated. Bit error rates <10(-9) are demonstrated for each waveform at various delay settings.
Experimental verification of a 3D scaling principle for low V<inf>ce(sat)</inf> IGBT (2016)

Three dimensionally (3D) scaled IGBTs that have a scaling factor of 3 (k=3) with respect to current commercial products (k=1) were fabricated for the first time. The scaling was applied to the lateral and vertical dimensions as well as the gate voltage. A significant decrease in ON resistance, - Vce(sat) reduction from 1.70 to 1.26 V - was experimentally confirmed for the 3D scaled IGBTs.
Corrigendum: An Extremely Long‐Lived Singlet 4,4‐Dimethoxy‐3,5‐diphenylpyrazolidine‐3,5‐diyl Derivative: A Notable Nitrogen‐Atom Effect on Intra‐ and Intermolecular Reactivity (2012)

In Scheme 1 of this Communication, formation of the MeO-migrated compound 10 a was reported for the photochemical denitrogenation of azoalkane AZ in benzene. 2D NMR spectroscopic analyses (HMBC, HMQC) of this reaction have now revealed that the product is not compound 10 a but compound 10 a'.
Imaging alveolar–capillary gas transfer using hyperpolarized 129 Xe MRI (2006)

Effective pulmonary gas exchange relies on the free diffusion of gases across the thin tissue barrier separating airspace from the capillary red blood cells (RBCs). Pulmonary pathologies, such as inflammation, fibrosis, and edema, which cause an increased blood-gas barrier thickness, impair the efficiency of this exchange. However, definitive assessment of such gas-exchange abnormalities is challenging, because no methods currently exist to directly image the gas transfer process. Here we exploit the solubility and chemical shift of (129)Xe, the magnetic resonance signal of which has been enhanced by 10(5) with hyperpolarization, to differentially image its transfer from the airspaces into the tissue barrier spaces and RBCs in the gas exchange regions of the lung. Based on a simple diffusion model, we estimate that this MR imaging method for measuring (129)Xe alveolar-capillary transfer is sensitive to changes in blood-gas barrier thickness of approximately 5 microm. We validate the successful separation of tissue barrier and RBC images and show the utility of this method in a rat model of pulmonary fibrosis where (129)Xe replenishment of the RBCs is severely impaired in regions of lung injury.
A Fine Structure Stimulation Strategy and Related Concepts (2012)

The auditory system provides a natural frequency-to-place mapping which is designated as tonotopic organisation of the cochlea. In the normal-hearing system, the acoustic signal causes a fluid pressure wave which propagates into the cochlea. At particular positions within the cochlea, most of the energy of the wave is absorbed causing mechanical oscillations of the basilar membrane. The oscillations are transduced into electrical signals (action potentials) in neurons by the action of the inner hair cells. Waves caused by low input frequencies travel further into the cochlea than those caused by high frequencies. Thus, each position of the basilar membrane can be associated with a particular frequency of the input signal (Greenwood, 1990). This natural form of frequency-to-place mapping, together with the fact that the positioning and fixation of an intrascalar electrode array is comparatively simple, is likely one of the most important factors for the success of cochlear implants as compared to other sensory neural prostheses.
Identification of the PDZ3 Domain of the Adaptor Protein PDZK1 as a Second, Physiologically Functional Binding Site for the C Terminus of the High Density Lipoprotein Receptor Scavenger Receptor Class B Type I (2011)

The normal expression, cell surface localization, and function of the murine high density lipoprotein receptor scavenger receptor class B type I (SR-BI) in hepatocytes in vivo, and thus normal lipoprotein metabolism, depend on its four PDZ domain (PDZ1-PDZ4) containing cytoplasmic adaptor protein PDZK1. Previous studies showed that the C terminus of SR-BI ("target peptide") binds directly to PDZ1 and influences hepatic SR-BI protein expression. Unexpectedly an inactivating mutation in PDZ1 (Tyr(20) → Ala) only partially, rather than completely, suppresses the ability of PDZK1 to control hepatic SR-BI. We used isothermal titration calorimetry to show that PDZ3, but not PDZ2 or PDZ4, can also bind the target peptide (K(d) = 37.0 μm), albeit with ∼10-fold lower affinity than PDZ1. This binding is abrogated by a Tyr(253) → Ala substitution. Comparison of the 1.5-Å resolution crystal structure of PDZ3 with its bound target peptide ((505)QEAKL(509)) to that of peptide-bound PDZ1 indicated fewer target peptide stabilizing atomic interactions (hydrogen bonds and hydrophobic interactions) in PDZ3. A double (Tyr(20) → Ala (PDZ1) + Tyr(253) → Ala (PDZ3)) substitution abrogated all target peptide binding to PDZK1. In vivo hepatic expression of a singly substituted (Tyr(253) → Ala (PDZ3)) PDZK1 transgene (Tg) was able to correct all of the SR-BI-related defects in PDZK1 knock-out mice, whereas the doubly substituted [Tyr(20) → Ala (PDZ1) + Tyr(253) → Ala (PDZ3)]Tg was unable to correct these defects. Thus, we conclude that PDZK1-mediated control of hepatic SR-BI requires direct binding of the SR-BI C terminus to either the PDZ1 or PDZ3 domains, and that binding to both domains simultaneously is not required for PDZK1 control of hepatic SR-BI.