gebhart/patrepeval huggingface dataset:
Adaptive subband video coding using bivariate generalized Gaussian distribution model (2002)

A multidimensional probabilistic modeling technique is proposed and its applications to video coding is presented. The probability distribution of two adjacent pixels in subband signals are modeled by bivariate generalized Gaussian distributions (GGD). Quantizer design, bit allocation and entropy coding is based on this probability distribution function (PDF) model. We show that use of bivariate generalized Gaussian PDF models yields a significant improvement in rate-distortion performance over univariate GGD models.
Adaptive modulation packet radio communication system using NP-CSMA/TDD scheme (2002)

This paper proposes an adaptive modulation packet radio communication system using nonpersistent carrier sense multiple access/time division duplex (NP-CSMA/TDD) scheme. This system controls the modulation parameters such as symbol rate, modulation level and packet length according to the channel conditions to improve the throughput and the average delay performances in heavy traffic conditions. Computer simulation confirms that the proposed system can achieve higher throughput and shorter average delay performances.
Equid Herpesvirus 1 Targets the Sensitization and Induction Steps To Inhibit the Type I Interferon Response in Equine Endothelial Cells (2019)

Equid herpesvirus 1 (EHV-1) is a viral pathogen of horse populations worldwide spread by the respiratory route and is known for causing outbreaks of neurologic syndromes and abortion storms. Previously, we demonstrated that an EHV-1 strain of the neuropathogenic genotype, T953, downregulates the beta interferon (IFN-β) response <i>in vitro</i> in equine endothelial cells (EECs) at 12 h postinfection (hpi). In the present study, we explored the molecular correlates of this inhibition as clues toward an understanding of the mechanism. Data from our study revealed that EHV-1 infection of EECs significantly reduced both Toll-like receptor 3 (TLR3) and TLR4 mRNA expression at 6 hpi and 12 hpi. While EHV-1 was able to significantly reduce IRF9 mRNA at both 6 hpi and 12 hpi, the virus significantly reduced IFN regulatory factor 7 (IRF7) mRNA only at 12 hpi. EHV-1 did not alter the cellular level of Janus-activated kinase 1 (JAK1) at any time point. However, EHV-1 reduced the cellular level of expression of tyrosine kinase 2 (TYK2) at 12 hpi. Downstream of JAK1-TYK2 signaling, EHV-1 blocked the phosphorylation and activation of signal transducer and activator of transcription 2 (STAT2) when coincubated with exogenous IFN, at 12 hpi, although not at 3 or 6 hpi. Immunofluorescence staining revealed that the virus prevented the nuclear translocation of STAT2 molecules, confirming the virus-mediated inhibition of STAT2 activation. The pattern of suppression of phosphorylation of STAT2 by EHV-1 implicated viral late gene expression. These data help illuminate how EHV-1 strategically inhibits the host innate immune defense by limiting steps required for type I IFN sensitization and induction.<b>IMPORTANCE</b> To date, no commercial vaccine label has a claim to be fully protective against the diseases caused by equid herpesvirus 1 (EHV-1), especially the neurologic form. The interferon (IFN) system, of which type I IFN is of great importance, still remains a viable immunotherapeutic option against EHV-1 infection. The type I IFN system has been exploited successfully to treat other viral infections, such as chronic hepatitis B and C in humans. The current state of research on how EHV-1 interferes with the protective effect of type I IFN has indicated transient induction of type I IFN production followed by a rapid shutdown <i>in vitro</i> in equine endothelial cells (EECs). The significance of our study is the identification of certain steps in the type I IFN signaling pathway targeted for inhibition by EHV-1. Understanding this pathogen-host relationship is essential for the long-term goal of developing effective immunotherapy against EHV-1.
Slurry Phase Hydrogenation of CO2 to Methanol Using Supported In2O3 Catalysts as Promising Approach for Chemical Energy Storage (2020)

Abstract A promising approach for chemical energy storage from fluctuating renewable electricity is methanol synthesis from CO 2 and hydrogen in a slurry reactor concept, due to efficient heat storage and easy reactor control. In combination with a promising In 2 O 3 /ZrO 2 catalyst and mineral oil as carrier liquid, efficient methanol production under a wide range of changing process conditions is shown for the first time. A maximum methanol productivity of 2.1 g MeOH g In −1 h −1 and multiple recycling stability of the catalyst and the carrier liquid was achieved, showing no significant decrease in methanol yields.
Photodynamic therapy induces an immune response against a bacterial pathogen (2012)

Photodynamic therapy (PDT) employs the triple combination of photosensitizers, visible light and ambient oxygen. When PDT is used for cancer, it has been observed that both arms of the host immune system (innate and adaptive) are activated. When PDT is used for infectious disease, however, it has been assumed that the direct antimicrobial PDT effect dominates. Murine arthritis caused by methicillin-resistant Staphylococcus aureus in the knee failed to respond to PDT with intravenously injected Photofrin(®). PDT with intra-articular Photofrin produced a biphasic dose response that killed bacteria without destroying host neutrophils. Methylene blue was the optimum photosensitizer to kill bacteria while preserving neutrophils. We used bioluminescence imaging to noninvasively monitor murine bacterial arthritis and found that PDT with intra-articular methylene blue was not only effective, but when used before infection, could protect the mice against a subsequent bacterial challenge. The data emphasize the importance of considering the host immune response in PDT for infectious disease.
Lessons from a Restricted Turing Test (1994)

We report on the recent Loebner prize competition inspired by Turing's test of intelligent behavior. The presentation covers the structure of the competition and the outcome of its first instantiation in an actual event, and an analysis of the purpose, design, and appropriateness of such a competition. We argue that the competition has no clear purpose, that its design prevents any useful outcome, and that such a competition is inappropriate given the current level of technology. We then speculate as to suitable alternatives to the Loebner prize.
Variant of Bartter’s Syndrome with a Distal Tubular rather than Loop of Henle Defect (1988)

A 19-year-old normotensive patient had all of the clinical features of Bartter's syndrome: hypokalemia, elevated renin and aldosterone levels and increased excretion of prostaglandin E. In contrast to the patients described by Bartter, the patient had a normal capacity to form solute-free water, suggesting intact loop of Henle function. Baseline potassium and chloride excretion rates were higher than those observed in 5 normal subjects, but the response to intravenous chlorothiazide, a drug which acts in the early distal convolute tubule, was abnormal. While chloride excretion rose by only 61% in this patient, it increased sixfold in the normal subjects. Sodium excretion quadrupled in the controls but less than doubled in this patients. Roughly equivalent increments in potassium excretion occurred in normals and controls, suggesting that the patient's distal potassium-secretory mechanism was intact. Review of the literature indicates that whether the site of the abnormal renal tubular potassium (chloride) leak is the proximal tubule, the loop of Henle or the distal convoluted tubule, patients may achieve features indistinguishable from those previously reported as characteristic for Bartter's syndrome. If loop of Henle malfunction is required to diagnose classical Bartter's syndrome, then our patient (and several reported elsewhere) has a variant form.
Integration of 150 Gbps/fiber optical engines based on multicore fibers and 6-channel VCSELs and PDs (2016)

Multicore fiber enables a parallel optic data link with a single optical fiber, thus providing an attractive way to increase the total throughput and the integration density of the interconnections. We study and present photonics integration technologies and optical coupling approaches for multicore transmitter and receiver subassemblies. Such optical engines are implemented and characterized using multimode 6-core fibers and multicore-optimized active devices: 850-nm VCSEL and PD arrays with circular layout and multi-channel driver and receiver ICs. They are developed for bit-rates of 25 Gbps/channel and beyond, i.e. &lt;150 Gbps per fiber, and also optimized for ruggedized transceivers with extended operation temperature range, for harsh environment applications, including space.
Stilbene disulfonic acids. CD4 antagonists that block human immunodeficiency virus type-1 growth at multiple stages of the virus life cycle (1991)

The stilbene disulfonic acids 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS), 4,4'-diisothiocyanatodihydrostilbene-2,2'-disulfonic acid and, 4-acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic acid bound the variable-1 immunoglobulin-like domain of CD4 on JM cells. The interaction blocked the binding of the anti-CD4 monoclonal antibody OKT4A and the envelope glycoprotein gp120 of the human immunodeficiency virus type-1 (HIV-1). DIDS inhibited the acute infection of CD4+ cells by HIV-1 with a potency (IC50 approximately 30 microM) similar to that which blocked gp120 binding (IC50 approximately 20 microM) to the cellular antigen. Pretreating uninfected CD4+ C8166 cells with DIDS blocked their fusion with chronically infected gp120+ cells. DIDS covalently and selectively modified lysine 90 of soluble CD4 and abolished the gp120-binding and antiviral properties of the recombinant protein. When added to cells productively infected with HIV-1, DIDS blocked virus growth and cleared cultures of syncytia without inhibiting cellular proliferation. The stilbene disulfonic acids are a novel class of site-specific CD4 antagonists that block multiple CD4-dependent events associated with acute and established HIV-1 infections.
Effect of Magnesium Ion on the Radical-Scavenging Rate of Pterostilbene in an Aprotic Medium: Mechanistic Insight into the Antioxidative Reaction of Pterostilbene (2022)

Pterostilbene (PTS), a methylated analog of resveratrol (RSV), has recently attracted much attention due to its enhanced bioavailability compared to RSV. However, little is known about the radical-scavenging mechanism of PTS. In this study, we investigated the effect of Mg(ClO<sub>4</sub>)<sub>2</sub> on the scavenging reaction of galvinoxyl radical (GO<sup>•</sup>) by PTS in acetonitrile (MeCN). GO<sup>•</sup> was used as a model for reactive oxygen radicals. The second-order rate constant (<i>k</i><sub>H</sub>) for the GO<sup>•</sup>-scavenging reaction by PTS was more than threefold larger than that by RSV, although thermodynamic parameters, such as the relative O-H bond dissociation energies of the phenolic OH groups, ionization potentials, and HOMO energies calculated by the density functional theory are about the same between PTS and RSV. The oxidation peak potential of PTS determined by the cyclic voltammetry in MeCN (0.10 M Bu<sub>4</sub>NClO<sub>4</sub>) was also virtually the same as that of RSV. On the other hand, no effect of Mg (ClO<sub>4</sub>)<sub>2</sub> on the <i>k</i><sub>H</sub> values was observed for PTS, in contrast to the case for RSV. A kinetic isotope effect of 3.4 was observed when PTS was replaced by a deuterated PTS. These results suggest that a one-step hydrogen-atom transfer from PTS to GO<sup>•</sup> may be the rate-determining step in MeCN.
The Histamine H4 Receptor and Potential Therapeutic Uses for H4 Ligands (2004)

Histamine is a biogenic amine that plays a host of physiological roles and the three major functions for histamine have been largely defined by the activity of three receptors. The inflammatory wheal and flare response is driven by the H1 receptor [1]. The H2 receptor controls gastric acid secretion in the gut [2]. The H3 receptor is involved in neurotransmitter release in the central nervous system [3]. The recent discovery of the histamine H4 receptor by several groups has lead to the re-evaluation of the physiological role for histamine.
Competitive cAMP Antagonists for cAMP-Receptor Proteins (1984)

The two exocyclic oxygen atoms at phosphorus of cAMP have been replaced by a sulfur atom or by a dimethylamino group. These substitutions introduce chirality at the phosphorus atom; therefore, two diastereoisomers are known for each derivative: (SP)-cAMPS, (RP)-cAMPS, (SP)-cAMPN(CH3)2, and RP-cAMPN(CH3)2. We have investigated the agonistic and antagonistic activities of these compounds in four cAMP-dependent reactions: activation of the cellular slime mold Dictyostelium discoideum via its cell surface cAMP receptor, and phosphorylation by cAMP-dependent protein kinases type I, type II (both mammalian enzymes), and type D (derived from D. discoideum). The results show that 1) the compounds (SP)-cAMPS and (Sp)-cAMPN(CH3)2 are (mostly full) agonists for the four proteins. Half-maximal activation is at micromolar concentrations (0.8-7 µM). 2) (RP)-cAMPS is a full antagonist for the cell surface receptor and protein kinases type I and II, with apparent inhibition constants between 0.8 and 8 µM. This compound is a partial agonist for protein kinase type D, where it induces maximally 50% activation of the enzyme if compared with cAMP. 3) (RP)-cAMPN(CH3)2 is a full antagonist for the cell surface receptor, and for protein kinase type II. This compound is a partial agonist for protein kinase type I (at least 50% activation if compared with cAMP), and inactive for protein kinase type D. This derivative is at least 25-fold less active as an antagonist than (RP)-cAMPS. 4) The activity of mixtures of different concentrations of the antagonist (RP)-cAMPS with different concentrations of cAMP reveals that the compound is a competitive antagonist of cAMP at micromolar concentrations.
Facile, Solvent‐Free Preparation of High Density, High Mass Loading Sulfur Cathodes Enabled by Dry‐Pressable Holey Graphene Scaffolds (2019)

Abstract For lithium‐sulfur (Li−S) batteries to be practically applicable in large scale, high mass loading and high S content are required for the sulfur (S) cathodes. Most reported S cathode preparation procedures, such as melt infiltration of S into carbon scaffolds followed by conventional solvent‐based slurry casting, are time‐consuming, costly, and lack control with respect to the electrode composition and quality. Here we report the use of a facile room‐temperature procedure that is especially useful in the preparation of high density, high mass loading S cathodes with convenient control of S content and electrode architecture. The solvent‐free and binder‐free procedure is enabled by the use of holey graphene (hG) as a unique dry‐pressable electrode scaffold host to effectively encapsulate S in the conductive matrix. The entire process can be completed within just a few minutes at room temperature, in comparison to much longer time required for most other methods. With effective S utilization, the high mass loadings and high densities of the dry‐pressed hG‐hosted S cathodes result in excellent areal (up to 20 mAh/cm 2 ) and volumetric performance (1787 mAh/cm 3 is the highest reported to date), respectively. The hG‐enabled dry‐press method therefore offers an attractive processing option for S composite cathode fabrication toward practical applications.
Abstract 425: Linked Target Capture: Rapid and high-performance NGS target enrichment for clinical sequencing applications (2018)

Abstract With the continued decrease of DNA sequencing costs, targeted next-generation sequencing (NGS) is seeing broad adoption in many research, commercial and clinical settings. However, current target capture methods typically have long, multiday workflows that can limit their clinical utility. In addition, small panels for applications such as liquid biopsy typically have high off-target rates or low uniformity, resulting in an increased cost of sequencing required to reach the desired coverage for variant detection. We have developed a novel library preparation and enrichment method named “Linked Target Capture” that replaces typical multiday "PCR-capture-PCR" workflows with a single, linked "PCR/capture" step. This approach, which uses physically linked capture probes and universal PCR primers, enables users to work from extracted DNA to loaded sequencer in less than a single day with minimal hands-on time. The linked PCR and capture step is cycled multiple times to reduce off-target DNA and increase uniformity, ultimately reducing the cost of sequencing. Additionally, the universal primers and captures probes can be combined to enable detection of DNA fusions with unknown partners. Using this method, we evaluated the ability to detect multiple mutation types from both tissue and cell free DNA, as a function of sequencing usage. Unique Molecular Identifiers (UMIs) were integrated and enabled the detection of variants below 0.1%, represented on both senses of the starting DNA (duplex sequencing). Fusion detection was also demonstrated without a priori knowledge of the fusion partner. Using a 30-gene pan-cancer panel, on-target fraction was measured to be above 95%, and the fraction of the panel covered at greater than 25% of the mean depth was greater than 99%. In summary, we have developed a method that enables rapid and cost-effective detection of clinically relevant cancer variants, such as SNVs and gene fusions. This method holds promise for many NGS areas, including clinical applications requiring rapid and simple workflows, or groups new to NGS where simple workflows and repeatable performance help remove barriers to technology adoption. Citation Format: Joel Pel, Wendy Choi, Milenko Despotovic, Laura Gelinas, Amy Leung, Lloyd Ung, Andre Marziali. Linked Target Capture: Rapid and high-performance NGS target enrichment for clinical sequencing applications [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 425.
Applications of emerging molecular technologies in glioblastoma multiforme (2008)

Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults. Median survival from the time of diagnosis is less than a year, with less than 5% of patients surviving 5 years. These tumors are thought to arise through two different pathways. Primary GBMs represent de novo tumors, while secondary GBMs represent the malignant progression of lower-grade astrocytomas. Moreover, despite improvements in deciphering the complex biology of these tumors, the overall prognosis has not changed in the past three decades. The hope for improving the outlook for these glial-based malignancies is centered on the successful clinical application of current high-throughput technologies. For example, the complete sequencing of the human genome has brought both genomics and proteomics to the forefront of cancer research as a powerful approach to systematically identify large volumes of data that can be utilized to study the molecular and cellular basis of oncology. The organization of these data into a comprehensive view of tumor growth and progression translates into a unique opportunity to diagnose and treat cancer patients. In this review, we summarize current genomic and proteomic alterations associated with GBM and how these modalities may ultimately impact treatment and survival.
Obesity and Cancer Mechanisms: Cancer Metabolism (2016)

Obesity is a risk factor for cancer development and is associated with poor prognosis in multiple tumor types. The positive energy balance linked with obesity induces a variety of systemic changes including altered levels of insulin, insulin-like growth factor-1, leptin, adiponectin, steroid hormones, and cytokines. Each of these factors alters the nutritional milieu and has the potential to create an environment that favors tumor initiation and progression. Although the complete ramifications of obesity as it relates to cancer are still unclear, there is convincing evidence that reducing the magnitude of the systemic hormonal and inflammatory changes has significant clinical benefits. This review will examine the changes that occur in the obese state and review the biologic mechanisms that connect these changes to increased cancer risk. Understanding the metabolic changes that occur in obese individuals may also help to elucidate more effective treatment options for these patients when they develop cancer. Moving forward, targeted clinical trials examining the effects of behavioral modifications such as reduced carbohydrate intake, caloric restriction, structured exercise, and/or pharmacologic interventions such as the use of metformin, in obese populations may help to reduce their cancer risk.
Resource allocation in the downlink of cellular multi‐hop networks (2007)

Abstract The growth of high‐data rate services on mobile cellular networks necessitates more efficient use of the finite bandwidth/power resources available. Ideally this should be achieved with minimum additional infrastructure since it is expensive both in terms of capital outlay and also network redesign. One such evolutionary path which is currently fuelling a lot of interest is multi‐hop. This scheme uses one or more relays to forward transmissions between the base station (BS) and the target user equipment (UE). Given a large enough density of relays, there will always be a more path loss efficient multi‐hop route between the BS and target UE than the direct hop one. However, it is not so obvious how this will translate into realizable improvements in cell throughput and coverage. The actual benefits of multi‐hop are dependent upon a number of key system choices such as the scheduling algorithm and type of antenna array processing used. This paper considers through simulation how the benefits of multi‐hop vary for systems that employ combinations of round robin or equal throughput scheduling with either 2 or 4 element maximal ratio combining. Copyright © 2007 John Wiley &amp; Sons, Ltd.
Analytic Review: Treatment of Coronary Artery Spasm and Variant Angina (1986)

Coronary artery spasm is an abnormal constriction of the conductive arteries that produces myocardial ischemia in the absence of any marked increase in heart rate or blood pressure. Ischemia is a transient phenomenon and is promptly reversed spontaneously or by nitroglycerine. The so-called "hallmark of spasm"—ST segment elevation—is evidence for severe myocardial ischemia rather than conclusive evidence for coronary artery spasm. Any process that transiently or permanently restricts coronary blood flow (e.g., transient occlusion by thrombus) will produce similar electrocardiogram (EKG) abnormalities. Most patients with symptoms and EKG changes related to coronary artery spasm respond to sublingual nitrates. Thus, their use for relief of the acute ischemic episode remains the initial treatment of choice. When symptoms are moderate in severity or unacceptably controlled in frequency using nitrates alone, other pharmacologic measures are needed. When spasm is superimposed upon hemodynamically important atherosclerotic obstruction, the favorable response to calcium antagonist may not be as great as that seen when spasm occurs alone. One possible explanation is that spasm is not really occurring. The ST segment elevation may be related to transient total occlusion from platelet aggregation or thrombosis. Thus, aspirin may be the drug of choice. However, if spasm is the culprit, recommendations for surgery and angioplasty require proof that spasm is occurring in and around the area of fixed atherosclerotic obstruction and not in other vessels or over the entire course of the distal vessel.