gebhart/patrepeval huggingface dataset:
Design and development of the wearable hand exoskeleton system for rehabilitation of hand impaired patients (2014)

In the past decade, the population of disability grew rapidly and became one of main problems in our society. The significant amounts of impaired patients include not only lower limb but also upper limb impairment such as the motor function of arm and hand. However, physical therapy requires high personal expenses and takes long time to complete the rehabilitation. In order to solve the problem mentioned above, a wearable hand exoskeleton system was developed in this paper. The hand exoskeleton system typically designed to accomplish the requirements for rehabilitation. Figure 1 shows the prototype of hand exoskeleton system which can be easily worn on human hand. The developed exoskeleton finger can provide bi-directional movements in bending and extension motion for all joints of the finger through cable transmission. The kinematic relations between the fingertip and metacarpal was derived and verified. Moreover, the construction of control system is presented in this paper. The preliminary experiment results for finger's position control have demonstrated that the proposed device is capable of accommodating to the aforementioned variables.
Lenalidomide/rituximab induces high molecular response in untreated follicular lymphoma: LYSA ancillary RELEVANCE study (2020)

Complete molecular response (CMR) after first-line immunochemotherapy reflects treatment efficacy and may predict prognosis in patients with follicular lymphoma (FL). RELEVANCE is the first phase 3 trial comparing the chemotherapy-free regimen lenalidomide/rituximab (R2) vs rituximab/chemotherapy (R-Chemo) in previously untreated FL patients (ClinicalTrials.gov identifier: NCT01650701). The objective of the minimal residual disease (MRD) analysis was to determine the ability of a chemotherapy-free regimen to induce CMR. Of 440 French patients participating in the Lymphoma Study Association (LYSA) RELEVANCE MRD study, all 222 patients with a BIOMED-2-detectable BCL2-JH translocation at diagnosis were analyzed. MRD was quantified by droplet digital polymerase chain reaction with a sensitivity ≤10-4. At week 24 (end of induction treatment), 98% and 78% of patients achieved CMR in peripheral blood (PB) and bone marrow (BM), respectively. Achievement of CMR (in PB and/or BM) had a significant impact on progression-free survival (PFS), with 3-year PFS of 84% and 55% for patients with CMR and detectable MRD, respectively (P = .015). CMR at week 24 was reached more frequently in the R2 arm (105/117; 90%) than in the R-Chemo arm (70/90; 77%) (P = .022). The poor prognostic value in terms of PFS for the persistence of molecular disease was observed irrespective of treatment arm (interaction test, P = .31). In agreement with the clinical results of the RELEVANCE trial, our results show that R2 immunomodulatory treatment in first-line FL can achieve high rates of CMR.
Auto-Encoder Based Orthogonal Time Frequency Space Modulation and Detection With Meta-Learning (2023)

To tackle a Doppler sensitivity problem of orthogonal frequency division multiplexing (OFDM), orthogonal time frequency space (OTFS) has been investigated, where information is carried over delay-Doppler domain. In this paper, to improve communication reliability in doubly dispersive channel, an auto-encoder (AE)-based OTFS modulation and detection scheme is developed, where the transmit OTFS waveform and its associated detection scheme at the receiver are jointly optimized in a deep learning framework. However, the conventional AE architecture which takes one-hot encoded input vector is hard to be reused in OTFS due to its enormous input dimensionality that increases exponentially on the number of grid points in delay-Doppler domain. To overcome it, we divide the delay-Doppler grid into multiple subblocks and associate the one-hot encoded vector with each subblock. Then, by concatenating them, one multi-hot vector is formed and exploited as the input vector for the proposed AE-based OTFS modulation and detection. We also develop a meta-learning scheme to effectively train the AE-based OTFS transceiver for newly updated channel profile.
An automated approach for verification of onchip interconnect resistance for electrostatic discharge paths (2011)

An automated method to verify low-ohmic interconnects for ESD protection network of a multi-million gate SoC design is demonstrated on full chip level. This closes a critical gap in the ESD verification and supersedes workarounds of the past. A structured breakup and assessment of the discharge paths is discussed.
Doxycycline Prevents Right Ventricular Dysfunction Induced by Pulmonary Embolism (2015)

Pulmonary embolism (PE) is commonly associated to right ventricular (RV) dysfunction, which predict poor outcome. Doxycycline pretreatment has been associated to beneficial effects after PE. However, no previous study has evaluated doxycycline posttreatment. Male Sprague‐Dawley rats (300‐350g) were anaesthetized with ketamine and xylazine. On day 1, the PE group received 85 µm polystyrene microspheres (221.000/100 g body wt, jugular vein) suspended in 0.01% Tween 20 and the Sham group received Tween only. Treatment animals received doxycycline (Doxy, 30mg/kg by gavage) and Controls received volume‐matched saline for 5 days after PE induction. Hearts were then extirpated from anesthetized animals on day 5 and perfused via the aorta using Langendorff technique with Krebs‐Henseleit buffer. We explored the Frank‐Starling relationship of RV contractile function (RV developed pressure, dP/dtmax and dP/dtmin) by increasing RV end diastolic pressures (from 0 to 40 mmHg). P&lt;0.05 was considered significant. In the PE group (n=6), ex vivo RV function was decreased significantly after 5 days compared with the Sham group (n=6), including RV developed pressure (PE, from 14±3.5 to 68±5.1 mmHg) vs (Sham, from 38±1.2 to 88±2.4 mmHg), dP/dtmax (PE, from 516±114 to 1022±201 mmHg/s) vs (Sham, from 1442±113 to 1826±75 mmHg/s), and dP/dtmin (PE, from ‐401±76 to ‐667±108 mmHg/s) vs (Sham, from ‐992±71 to ‐1185±77 mmHg/s). When compared with PE group, Treatment animals (PE+Doxy, n=6) had significantly improved RV function (from 35±4.0 to 89±1.7 mmHg), (from 1411±198 to 2034±149 mmHg/s) and (‐852±126 to ‐1119±87 mmHg/s) respectively. Doxycycline improved the intrinsic RV contractile dysfunction caused by PE. Doxycycline may help preserve RV function and decrease morbidity after PE.
Metabolic ensemble modeling for strain engineers (2011)

Previous mathematical modeling efforts have made significant contributions to the development of systems biology for predicting biological behavior quantitatively. However, dynamic metabolic model construction remains challenging due to uncertainties in mechanistic structures and parameters. In addition, parameter estimation and model validation often require designated experiments conducted only for purpose of modeling. Such difficulties have hampered the progress of modeling in biology and biotechnology. To circumvent these problems, ensemble approaches have been used to account for uncertainties in model structure and parameters. Specifically, this review focuses on approaches that utilize readily available fermentation data for parameter screening and model validation. Time course data for metabolite measurements, if available, can further calibrate the model. The basis for this approach is explained in non-mathematical terms accessible to experimentalists. Information gained from such an approach has been shown to be useful in designing Escherichia coli strains for metabolic engineering and synthetic biology.
Characterization and Optimization of a Real-Time, Parallel, Label-Free, Polypyrrole-Based DNA Sensor by Surface Plasmon Resonance Imaging (2000)

We describe in this paper a methodology to quantify multispot parallel DNA hybridizations and denaturations on gold surfaces by using, on one hand, a polypyrrole-based surface functionalization based on an electrospotting process and, on the other hand, surface plasmon resonance imaging allowing real-time measurements on several DNA spots at a time. Two characterization steps were performed in order to optimize the immobilization of oligonucleotide probes and, thus, to increase the signal-to-noise ratio of monitored hybridization signals: the first step consisted of characterizing the signal dependence upon the density of immobilized 15-mer probes, and, the second step, in analyzing the hybridization response versus spot thickness. We further demonstrated that a surface density of polypyrrole/DNA probes of approximately 130 fmol/ mm2 (590 pg/mm2) optimizes the hybridization signal that can be detected directly. Optimal thickness of the spot was found to be close to 11 nm. Specificity and regeneration steps on each spot have also been demonstrated successfully, showing this method to be very competitive and convenient in use.
A Simple Method to Increase the Transduction Efficiency of Single-Stranded Adeno-Associated Virus Vectors In Vitro and In Vivo (2011)

We have recently shown that co-administration of conventional single-stranded adeno-associated virus 2 (ssAAV2) vectors with self-complementary (sc) AAV2-protein phosphatase 5 (PP5) vectors leads to a significant increase in the transduction efficiency of ssAAV2 vectors in human cells in vitro as well as in murine hepatocytes in vivo. In the present study, this strategy has been further optimized by generating a mixed population of ssAAV2-EGFP and scAAV2-PP5 vectors at a 10:1 ratio to achieve enhanced green fluorescent protein (EGFP) transgene expression at approximately 5- to 10-fold higher efficiency, both in vitro and in vivo. This simple coproduction method should be adaptable to any ssAAV serotype vector containing transgene cassettes that are too large to be encapsidated in scAAV vectors.
ChemInform Abstract: Synthesis of the α‐Methyl Ketoside of 5‐Amino Neuraminic Acid Methyl Ester (VIII) and Its Corresponding 5‐Myristoyl (X) and 5‐ Cyclopropanoyl Derivative (XII). (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
1H NMR-Based Protocol for the Detection of Adulterations of Refined Olive Oil with Refined Hazelnut Oil (2009)

A (1)H NMR analytical protocol for the detection of refined hazelnut oils in admixtures with refined olive oils is reported according to ISO format. The main purpose of this research activity is to suggest a novel analytical methodology easily usable by operators with a basic knowledge of NMR spectroscopy. The protocol, developed on 92 oil samples of different origins within the European MEDEO project, is based on (1)H NMR measurements combined with a suitable statistical analysis. It was developed using a 600 MHz instrument and was tested by two independent laboratories on 600 MHz spectrometers, allowing detection down to 10% adulteration of olive oils with refined hazelnut oils. Finally, the potential and limitations of the protocol applied on spectrometers operating at different magnetic fields, that is, at the proton frequencies of 500 and 400 MHz, were investigated.
B cell maturation antigen–specific CAR T cells are clinically active in multiple myeloma (2019)

University of Pennsylvania-Novartis Alliance and NIH.
Data from X- and Y-Linked Chromatin-Modifying Genes as Regulators of Sex-Specific Cancer Incidence and Prognosis (2023)

&lt;div&gt;Abstract&lt;p&gt;Biological sex profoundly conditions organismal development and physiology, imposing wide-ranging effects on cell signaling, metabolism, and immune response. These effects arise from sex-specified differences in hormonal exposure, and from intrinsic genetic and epigenetic differences associated with the presence of an XX versus XY chromosomal complement. In addition, biological sex is now recognized to be a determinant of the incidence, presentation, and therapeutic response of multiple forms of cancer, including cancers not specifically associated with male or female anatomy. Although multiple factors contribute to sex-based differences in cancer, a growing body of research emphasizes a role for differential activity of X- and Y-linked tumor-suppressor genes in males and females. Among these, the X-linked &lt;i&gt;KDM6A/UTX&lt;/i&gt; and &lt;i&gt;KDM5C/JARID1C/SMCX&lt;/i&gt;, and their Y-linked paralogs &lt;i&gt;UTY&lt;/i&gt;/&lt;i&gt;KDM6C&lt;/i&gt; and &lt;i&gt;KDM5D/JARID1D/SMCY&lt;/i&gt; encode lysine demethylases. These epigenetic modulators profoundly influence gene expression, based on enzymatic activity in demethylating H3K27me3 and H3K4me3, and nonenzymatic scaffolding roles for large complexes that open and close chromatin for transcription. In a growing number of cases, mutations affecting these proteins have been recognized to strongly influence cancer risk, prognosis, and response to specific therapies. However, sex-specific patterns of mutation, expression, and activity of these genes, coupled with tissue-specific requirement for their function as tumor suppressors, together exemplify the complex relationship between sex and cancer vulnerabilities. In this review, we summarize and discuss the current state of the literature on the roles of these proteins in contributing to sex bias in cancer, and the status of clinical agents relevant to their function.&lt;/p&gt;&lt;/div&gt;
Comparative evaluation of carcinoembryonic antigen and gross cystic disease fluid protein as plasma markers for human breast carcinoma (1978)

A comparative evaluation of carcinoembryonic antigen (CEA) and gross cystic disease fluid protein (GCDFP) as plasma markers for human breast carcinoma has been performed. Both assays appear to be useful in patients with metastatic breast carcinoma. Of 216 patients under treatment for metastatic disease, 111 (51%) had abnormal plasma levels of CEA and/or GCDFP. Abnormal plasma levels of CEA were present in 73 patients whereas abnormal GCDFP levels were present in 67. Twenty-nine patients had increased plasma levels of both markers simultaneously, 44 patients had increased CEA levels only and 38 patients had increased GCDFP levels only. Thus, of the 111 patients with elevated levels of either CEA or GCDFP, the two markers varied independently of each other in 74%. Utilizing both assays, abnormal plasma levels were present in 79% of patients with osseous metastasis, 53% of patients with visceral metastasis and 26% with soft tissue metastasis. Both assays, when performed serially in patients treated for metastatic breast carcinoma, were found to have utility in monitoring responsiveness; an increasing CEA or GCDFP plasma level indicated disease progression and a decreasing plasma level indicated regression.
Faraday cage angled-etching of nanostructures in bulk dielectrics (2016)

For many emerging optoelectronic materials, heteroepitaxial growth techniques do not offer the same high material quality afforded by bulk, single-crystal growth. However, the need for optical, electrical, or mechanical isolation at the nanoscale level often necessitates the use of a dissimilar substrate, upon which the active device layer stands. Faraday cage angled-etching (FCAE) obviates the need for these planar, thin-film technologies by enabling in situ device release and isolation through an angled-etching process. By placing a Faraday cage around the sample during inductively coupled plasma reactive ion etching, the etching plasma develops an equipotential at the cage surface, directing ions normal to its face. In this article, the effects that Faraday cage angle, mesh size, and sample placement have on etch angle, uniformity, and mask selectivity are investigated within a silicon etching platform. Simulation results qualitatively confirm experiments and help to clarify the physical mechanisms at work. These results will help guide FCAE process design across a wide range of material platforms.
ChemInform Abstract: THERMOCHEMISCHE UNTERSUCHUNG DER PROTONIERUNG VON 1,3,5‐TRIAMINO‐BENZOL (1970)

Abstract Die Protonierung der Titelverbindung bei 6, l4 und 24°C ergibt bei einem pH‐ Wert von 5,5 ein Gleichgewicht zwischen einer N‐protonierten und einer C‐protonierten Form, dessen Lage von der Stabilität der beiden Formen bei denverschiedenen Temperaturen abhängt.
Colorectal Cancer Vaccines: Antiidiotypic Antibody, Recombinant Protein, and Viral Vector (2000)

The colorectal cancer antigen GA733 (also termed CO17-1A, KSI-4, Ep-CAM, KSA) has proved to be a useful target in passive immunotherapy with monoclonal antibody and in active immunotherapy with antiidiotypic antibodies in cancer patients. The GA733 antigen was molecularly cloned and expressed in baculovirus (BV), adenovirus (AV), and vaccinia virus (VV). Recombinant BV-, VV-, and AV-GA733 induced antigen-specific cytotoxic antibodies and proliferative and delayed-type hypersensitive lymphocytes. However, only the AV recombinant induced antigen-specific cytolytic T lymphocytes and regression of established tumors. Cured mice were protected against challenge with antigen-negative tumors, indicating antigen spreading of immune responses. In a model of active immunotherapy against the murine homologue of the human GA733 antigen, murine epithelial glycoprotein (mEGP), BV-derived mEGP protein in various adjuvants did not protect mice against a challenge with mEGP-positive tumors. AV mEGP, only when combined with interleukin-2, significantly inhibited growth of established mEGP-positive tumors. This is in contrast to the same vaccine expressing the human antigen that was effective without interleukin-2. AV GA733, in combination with interleukin-2, is a candidate vaccine for colorectal cancer patients.
Discovering dynamic patterns from infectious disease data using dynamic mode decomposition (2015)

We demonstrate how DMD can aid in the analysis of spatial-temporal disease data. DMD is poised to be an effective and efficient computational analysis tool for the study of infectious disease.
Traffic Aware Beamformer Design for Integrated Access and Backhaul with Flexible TDD (2020)

Integrated access and backhaul (IAB) networks consist of IAB-donor, IAB-nodes, and user-equipments (UEs). Both IAB-donor and IAB-node provide access to UEs while IAB-donor and IAB-nodes exchange UEs data via wireless in-band backhaul using the same frequency-time resources shared with access links. Multi-antenna beamformer techniques can be used to mitigate the complicated cross-link interference scenarios arising from IAB systems. In this paper, an iterative beamformer design with the weighted queue minimization (WQM) objective is proposed for the time-division-duplexed (TDD) based IAB system. In the considered TDD based IAB model, in a given timeslot, IAB-nodes and IAB-donor are assumed to be different uplink (UL)/downlink (DL) transmission modes to mitigate conventional half-duplex loss. Also, the beamformer design is carried out over two timeslots, considering both UL and DL transmission at each node. Specifically, user-specific UL/DL queues are introduced at the IAB-nodes to guarantee the BS to/from UE data delivery. The proposed beamformer solution is based on the iterative evaluation of Karush-Kuhn-Tucker (KKT) conditions of the optimization problem, which can practically be implemented in both centralized and decentralized manner. The numerical examples illustrate the superior system performance of the proposed method in comparison to the conventional half-duplex relaying system.
Channel Modeling for V2V Communications (2006)

In this paper we describe results of a channel measurement campaign for modeling the V2V channel. After review of applications, potential frequency bands, and related work, we describe the measurements and results for delay spreads and multipath component fading amplitudes and correlations, made in multiple V2V environments. We also note how the V2V channel can differ appreciably from other common terrestrial (e.g., cellular) channels. We describe considerations used in developing the statistical channel models for these environments, and provide some example measurement and modeling results that should be useful for system designers in future V2V applications.
A nuclear plant design for the 1990'S ― Meeting tomorrow's needs (1983)

This paper describes the Advanced Pressurized Water Reactor (PWR) Model Development Program initiated by Westinghouse in 1977. The design objectives of the program are reduced economic risk to the utility and risk to the public, 90% plant availability and improved component reliability, significant reduction in uranium ore requirements and separative work units (SWUs), reduced construction costs, reduced occupational radiation exposure (ORE), and increased design margins. Reduced economic and public risk have been accomplished in the design of the plant by ensuring no core uncovery occurs during small break loss of coolant accidents (LOCA). It is predicted that the Japanese will build the described advanced plant.
Granulocyte-macrophage colony-stimulating factor synergizes with interleukin-6 in supporting the proliferation of human myeloma cells [see comments] (1990)

The role of granulocyte-macrophage colony-stimulating factor (GM-CSF) in the growth of multiple myeloma (MM) was investigated in 21 patients with MM. In 17 patients with proliferating myeloma cells in vivo, recombinant GM-CSF significantly increased the endogenous-IL-6-mediated spontaneous myeloma cell proliferation occurring in 5-day cultures of tumor cells in vitro (P less than .01). Furthermore, GM-CSF was detected in 5-day culture supernatants of myeloma bone marrow cells. This endogenous GM-CSF was produced by the myeloma bone marrow microenvironment but not by myeloma cells and contributed to the spontaneous myeloma-cell proliferation observed in 5-day cultures. In fact, this proliferation was partially blocked (67%) by anti-GM-CSF monoclonal antibodies. The stimulatory effect of rGM-CSF was mediated through IL-6 because it was abrogated by anti-IL-6 monoclonal antibodies. rGM-CSF did not reproducibly increase the endogenous IL-6 production in short-term cultures of bone marrow cells of MM patients. Using an IL-6-dependent myeloma cell line (XG-1 cell line), rGM-CSF was shown to act directly on myeloma cells stimulating by twofold their IL- 6 responsiveness. rGM-CSF did not induce any IL-6 production in XG-1 cells, nor was it able to sustain their growth alone. Although no detectable GM-CSF levels were found in the peripheral or bone marrow blood of MM patients, it is possible that GM-CSF, produced locally by the tumoral environment, enhances the IL-6 responsiveness of myeloma cells in vivo in a way similar to that reported here in vitro.
Modulating G-Protein Coupled Receptor/G-Protein Signal Transduction by Small Molecules Suggested by Virtual Screening (2008)

Modulation of interactions between activated GPCRs (G-protein coupled receptors) and the intracellular (IC) signal transducers, heterotrimeric G-proteins, is an attractive, yet essentially unexplored, paradigm for treatment of certain diseases. Regulating downstream signaling for treatment of congenital diseases due to constitutively active GPCRs, as well as tumors where GPCRs are often overexpressed, requires the development of new methodologies. Modeling, experimental data, docking, scoring, and experimental testing (MEDSET) was developed to discover inhibitors that target the IC loops of activated GPCRs. As proof-of-concept, MEDSET developed and utilized a model of the interface between photoactivated rhodopsin (R*) and transducin (Gt), its G-protein. A National Cancer Institute (NCI) compound library was screened to identify compounds that bound at the interface between R* and its G-protein. High-scoring compounds from this virtual screen were obtained and tested experimentally for their ability to stabilize R* and prevent Gt from binding to R*. Several compounds that modulate signal transduction have been identified.