gebhart/patrepeval huggingface dataset:
Re: Quantification of External Urethral Sphincter and Bladder Activity During Micturition in the Intact and Spinally Transected Adult Rat (2011)

No AccessJournal of UrologyInvestigative Urology1 Nov 2011Re: Quantification of External Urethral Sphincter and Bladder Activity During Micturition in the Intact and Spinally Transected Adult Rat Anthony AtalaM.D. Anthony AtalaAnthony Atala More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.07.054AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Re: Quantification of External Urethral Sphincter and Bladder Activity During Micturition in the Intact and Spinally Transected Adult Rat." The Journal of Urology, 186(5), p. 2124 © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 186Issue 5November 2011Page: 2124 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Anthony Atala More articles by this author Expand All Advertisement PDF downloadLoading ...
Dynamic Lumped Element Response of the Human Fingerpad (1999)

The dynamic response of the fingerpad plays an important role in the tactile sensory response and precision manipulation, as well as in ergonomic design. This paper investigates the dynamic lumped element response of the human fingerpad in vivo to a compressive load. A flat probe indented the fingerpad at a constant velocity, then held a constant position. The resulting force (0-2 N) increased rapidly with indentation then relaxed during the hold phase. A quasilinear viscoelastic model successfully explained the experimental data. The instantaneous elastic response increased exponentially with position, and the reduced relaxation function included three decaying exponentials (with time constants of approximately 4 ms, 70 ms, and 1.4 s) plus a constant. The model was confirmed with data from sinusoidal displacement trajectories.
Antiapoptosis potential of bcl-2 oncogene by dephosphorylation (1994)

The antiapoptosis potential of bcl-2 has now been well established. But the biochemical mechanism of bcl-2 action is still poorly understood. Using the phosphatase inhibitor okadaic acid (OA) or chemotherapeutic agents such as Taxol and 5'-fluorouracil, we found that bcl-2 can be phosphorylated. Since OA or Taxol treatment leads to apoptosis, it seems that phosphorylation of bcl-2 leads to its inactivation. Exposure of several lymphoid cell lines expressing differential amounts of bcl-2 protein to OA resulted in apoptosis of the cells and hyperphosphorylation of bcl-2. Interestingly, the lymphoblastoid cell lines that did not phosphorylate bcl-2 following OA exposure did not undergo apoptosis. Moreover, pro-B cells isolated from patients with acute lymphoblastic leukemias exhibited endogenous phosphorylated forms of bcl-2 and a large number of apoptotic cells, even without OA treatment. Treatment with the phosphatase inhibitor or with chemotherapeutic agents (Taxol, 5'-fluorouracil) led to severe apoptosis of these cells, along with hyperphosphorylation of bcl-2. Phosphoamino acid analysis reveals that bcl-2 is phosphorylated at a serine residue. In summary, our investigation indicates that the phosphorylation pathway involving bcl-2 can be the determinant of cell death in lymphocytes.
Detector size and geometry optimization for the helmet-chin PET (2016)

High sensitivity, high spatial resolution and low cost dedicated brain PET scanners are required for early diagnosis of Alzheimer's disease and brain function studies. As an optimal geometry, we proposed and developed the first prototype of the helmet-chin PET scanner. The scanner was constructed from 4-layer DOI detectors constructed from GSO crystals which were originally developed for our OpenPET. The helmet part of the helmet-chin PET consisted of three ring detectors with different radii arranged on a surface of a hemisphere and a top cover. In this study, for our next development, we optimized the size of the detectors to be arranged on the helmet, and compared two types of geometrical arrangements of the detectors on the hemisphere: a spherical arrangement in which the center of each detector faces toward the center of the hemisphere, and a multi-ring arrangement which has a similar detector arrangement to that of the first prototype. Geant4 simulation toolkit was used to model the scanners. The simulated scanners were constructed from LYSO crystals with a size of 1 × 1 × 5 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> (transaxial × axial × DOI). A dead-space of 2 mm was assumed in the axial and transaxial directions of the detector such as for wrapping. While fixing the number of the DOI layers to 4, the size of the detectors was varied by changing the number of crystals in the transaxial and axial directions. The results showed that, for the helmet detector, a detector with a size of 42 × 42 × 20 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> had the highest sensitivity evaluated using a hemispherical phantom. Then, the helmet-chin PET was modeled based on a detector whose size is 42 × 42 × 20 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> with the two geometrical arrangements and their sensitivities were compared. The respective sensitivities for hemispherical and multi-ring arrangements were 3.4% and 2.9% for a hemispherical phantom.
The unraveling of substrate specificity of histone deacetylase 6 domains using acetylome peptide microarrays and peptide libraries (2018)

Histone deacetylase 6 (HDAC6) is a multidomain cytosolic hydrolase acting mostly on nonhistone protein substrates. Investigations of the substrate specificity of HDAC6 are confounded by the presence of 2 catalytically active deacetylase domains (DD1 and DD2). In this study, acetylome peptide microarrays and peptide libraries were used to map the substrate specificity of DD1 and DD2 of human HDAC6. The results show that DD1 is solely responsible for the deacetylation of substrates harboring the acetyllysine at their C terminus, whereas DD2 exclusively deacetylates peptides with an internal acetyllysine residue. Also, statistical analysis of the deacetylation data revealed amino acid preferences at individual positions flanking the acetyllysine, where glycine and arginine residues are favored at positions N-terminal to the central acetyllysine; negatively charged glutamate is strongly disfavored throughout the sequence. Finally, the deacylation activity of HDAC6 was profiled by using a panel of acyl derivatives of the optimized peptide substrate and showed that HDAC6 acts as a proficient deformylase. Our data thus offer a detailed insight into the substrate preferences of the individual HDAC6 domains at the peptide level, and these findings can in turn help in elucidating the biologic roles of the enzyme and facilitate the development of new domain-specific inhibitors as research tools or therapeutic agents.-Kutil, Z., Skultetyova, L., Rauh, D., Meleshin, M., Snajdr, I., Novakova, Z., Mikesova, J., Pavlicek, J., Hadzima, M., Baranova, P., Havlinova, B., Majer, P., Schutkowski, M., Barinka, C. The unraveling of substrate specificity of histone deacetylase 6 domains using acetylome peptide microarrays and peptide libraries.
ChemInform Abstract: Nanoporous Aluminosilicate Catalyzed Friedel—Crafts Alkylation Reactions of Indoles with Aldehydes and Acetals. (2011)

Abstract An efficient catalyst is used in the presented synthesis.
Guest editors' introduction: on-chip power distribution networks (2003)

Presents the guest editorial for this issue of the publication.
Introduction to real-time ray tracing (2005)

Article Share on Introduction to real-time ray tracing Authors: Philipp Slusallek Saarland University, Saarbrücken, Germany Saarland University, Saarbrücken, GermanyView Profile , Peter Shirley University of Utah, Salt Lake City, UT University of Utah, Salt Lake City, UTView Profile , William Mark University of Texas at Austin, Austin, TX University of Texas at Austin, Austin, TXView Profile , Gordon Stoll Intel Corporation, Santa Clara, CA Intel Corporation, Santa Clara, CAView Profile , Ingo Wald Max-Planck-Institut für Informatik, Saarbrücken, Germany Max-Planck-Institut für Informatik, Saarbrücken, GermanyView Profile Authors Info & Claims SIGGRAPH '05: ACM SIGGRAPH 2005 CoursesJuly 2005 Pages 1–eshttps://doi.org/10.1145/1198555.1198740Online:31 July 2005Publication History 6citation1,008DownloadsMetricsTotal Citations6Total Downloads1,008Last 12 Months22Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Frontispiece: Size independent blue luminescence in nitrogen passivated silicon nanocrystals (Phys. Status Solidi A 10/2012) (2012)

Surface chemistry can play an important role in determining the optical properties of silicon nanocrystals. On this page, referring to the article by Mita Dasog and Jonathan G. C. Veinot (pp. 1844–1846) it is shown that by changing the surface of silicon nanocrystals, their emission color can be tuned. Hydride surface terminated silicon nanocrystals emit red/orange whereas, when surface groups attached through nitrogen atoms are present they emit blue. Chloride atoms quench the photoluminescence. The photoluminescence properties are shown as a background together with a transmission electron micrograph image of silicon nanocrystals.
Introduction (2007)

No AccessCo-Rotating Twin-Screw ExtruderNov 2007IntroductionKlemens KohlgrüberKlemens Kohlgrüberhttps://doi.org/10.3139/9783446433410.001SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2007Pages: 1-7Print ISBN: 978-3-446-41372-6eISBN: 978-3-446-43341-0 Copyright & Permissions© 2008 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
Rigorous coupled-wave analysis calculus of submicrometer interference pattern and resolving edge position versus signal-to-noise ratio (2002)

Universita¨t StuttgartInstitut fu¨r Technische OptikPfaffenwaldring 970569 Stuttgart, DeutschlandE-mail: tavrov@ito.uni-stuttgart.deAbstract. The signal-to-noise ratio required to obtain 10-nm accuracy inthe measurement of lateral position is studied with an interference mi-croscope. Evaluations are performed using the rigorous coupled-waveanalysis (RCWA) modal approach and Hopkins image formation theory.
New Total Ossicular Replacement Prostheses With a Resilient Joint (2011)

Hypothesis New flexible total ossicular prostheses with an integrated microjoint can compensate for large static displacements in the reconstructed ossicular chain. When properly designed, they can mimic the function of the joints of the intact chain and ensure good vibration transfer in both straight and bent conditions. Background Prosthesis dislocations and extrusions are frequently observed after middle ear surgery. They are mainly related to the altered distance between the coupling points because of large static eardrum displacements. Methods The new prostheses consist of 2 titanium shafts, which are incorporated into a silicone body. The sound transfer function and stapes footplate displacement at static loads were evaluated in human temporal bones after ossicular reconstruction using prostheses with 2 different silicones with different hardness values. The stiffness and bending characteristics of the prostheses were investigated with a quasi-static load. Results The sound transfer properties of the middle ears with the prostheses inserted under uncompressed conditions were comparable with those of ears with intact ossicular chains. The implant with the soft silicone had improved acoustic transfer characteristics over the implant with the hard silicone in a compressed state. In the quasi-static experiments, the minimum medial footplate displacement was found with the same implant. The bending characteristics depended on the silicone stiffness and correlated closely with the point and angle of the load incidence. Conclusion The titanium prostheses with a resilient joint that were investigated in this study had good sound transfer characteristics under optimal conditions as well as in a compressed state. As a result of joint bending, the implants compensate for the small changes in length of the ossicular chain that occur under varying middle ear pressure. The implants require a stable support at the stapes footplate to function properly.
Current control method for distributed generation power generation plants under grid fault conditions (2011)

The operation of distributed power generation systems under grid fault conditions is a key issue for the massive integration of renewable energy systems. Several studies have been conducted to improve the response of such distributed generation systems under voltage dips. In spite of being less severe, unbalanced fault cause a great number of disconnections, as it may produce the injection of unbalanced currents that can easily conduct to the tripping of the converter. In this paper a current control strategy for power converters able to deal with these grid conditions, without exceeding the current ratings of the converter is introduced. Moreover, a novel flexible algorithm has been proposed in order to regulate easily the injection of positive and negative currents for general purpose applications.
Multi-parametric magnetic resonance imaging as a management decision tool (2017)

The ability to image the prostate accurately and better characterize cancerous lesions makes multiparametric magnetic resonance imaging (mpMRI) an invaluable tool to improve management of localized prostate cancer (PCa). Improved risk stratification is warranted given the evidence of significant overtreatment of indolent PCa. mpMRI can more accurately rule out clinically significant PCa in men deciding between surveillance and definitive treatment to reduce overtreatment. mpMRI improves detection of clinically significant PCa, which helps minimize sampling error, a major limitation of the traditional diagnostic paradigm. Aside from helping determine candidacy for initial surveillance <i>vs</i>. treatment, mpMRI is a useful tool for following men on active surveillance (AS) with the potential to reduce the need for serial biopsies. When definitive treatment is warranted, mpMRI can be used to determine the local extent of disease. This provides information that is useful in the treatment decision, counseling about outcomes, and surgical planning. While mpMRI is a significant step forward in PCa management, it is necessary to understand its limitations. mpMRI and MRI-guided fusion biopsy techniques still do not detect all clinically significant tumors. The utility of current mpMRI techniques is limited by the multifocal nature of PCa with poor detection of non-index lesions, inaccurate estimation of tumor size and geometry, and the need for interpretation by specialized radiologists. The role of mpMRI will continue to expand as improvements in technology and experience help overcome these limitations.
Recent developments in solid state lasers (1989)

The field of solid state lasers has experienced a renascence of research interest and advancement in recent years. Novel or significantly improved laser source capabilities (wavelength tunability, ultrashort pulse duration, efficiency, energy, power, etc.) have been realized through a combination of factors: (1) increased fundamental knowledge of the spectrokinetic phenomena involving the laser and sensitizer ions embedded in the host solid state material; (2) the identification, synthesis, and development of new laser materials, (3) the development and application of high performance semiconductor laser diode pump sources in several critical wavelength regions; and (4) the introduction of novel pumping and output beam mode control strategies.
Light propagation within N95 filtered face respirators: A simulation study for UVC decontamination (2020)

This study presents numerical simulations of UVC light propagation through seven different filtered face respirators (FFR) to determine their suitability for Ultraviolet germicidal inactivation (UVGI). UV propagation was modeled using the FullMonte program for two external light illuminations. The optical properties of the dominant three layers were determined using the inverse adding doubling method. The resulting fluence rate volume histograms and the lowest fluence rate recorded in the modeled volume, sometimes in the nW cm<sup>-2</sup> , provide feedback on a respirator's suitability for UVGI and the required exposure time for a given light source. While UVGI can present an economical approach to extend an FFR's useable lifetime, it requires careful optimization of the illumination setup and selection of appropriate respirators.
Tissue-type imaging (TTI) based on ultrasonic spectral and clinical parameters for detecting, evaluating, and managing prostate cancer (2005)

This study seeks to develop more-sensitive and -specific ultrasonic methods of imaging cancerous prostate tissue and thereby to improve means of guiding biopsies and planning, targeting, and monitoring treatment. Ultrasonic radio-frequency, echo-signal data, and clinical variables, e.g., PSA, voiding function, etc., during biopsy examinations were acquired. Spectra of the radio-frequency signals were computed in each biopsied region, and used to train neural networks; biopsy results served as the gold standard. A lookup table gave scores for cancer likelihood on a pixel-by-pixel basis from locally computed spectral-parameter and global clinical-parameter values. ROC curves used leave-one-patient- and leave-one-biopsy-out approaches to minimize classification bias. Resulting ROC-curve areas were 0.80±0.03 for neural-networks versus 0.66±0.03 for conventional classification. TTIs generated from data acquired pre-surgically showed tumors that were unrecognized in conventional images and during surgery. 3-D renderings of prostatectomy histology and TTIs showed encouraging correlations, which shows promise for improving the detection and management of prostate cancer, e.g., for biopsy guidance, planning dose-escalation and tissue-sparing options for radiation or cryotherapy, and assessing the effects of treatment. Combining MRS parameters with US spectral parameters appears capable of further improving prostate-cancer imaging. [Work supported by NIH.]
A new device concept for directly modulating spinal cord pathways: initialin vivoexperimental results (2012)

We describe a novel spinal cord (SC) stimulator that is designed to overcome a major shortcoming of existing stimulator devices: their restricted capacity to selectively activate targeted axons within the dorsal columns. This device overcomes that limitation by delivering electrical stimuli directly to the pial surface of the SC. Our goal in testing this device was to measure its ability to physiologically activate the SC and examine its capacity to modulate somatosensory evoked potentials (SSEPs) triggered by peripheral stimulation. In this acute study on adult sheep (n = 7), local field potentials were recorded from a grid placed in the subdural space of the right hemisphere during electrical stimulation of the left tibial nerve and the spinal cord. Large amplitude SSEPs (>200 µV) in response to SC stimulation were consistently obtained at stimulation strengths well below the thresholds inducing neural injury. Moreover, stimulation of the dorsal columns with signals employed routinely by devices in standard clinical use, e.g., 50 Hz, 0.2 ms pulse width, produced long-lasting changes (>4.5 h) in the SSEP patterns produced by subsequent tibial nerve stimulation. The results of these acute experiments demonstrate that this device can be safely secured to the SC surface and effectively activate somatosensory pathways.
Telomerase Inhibition, Telomere Shortening, and Decreased Cell Proliferation by Cell Permeable 2‘-O-Methoxyethyl Oligonucleotides (2002)

Telomerase is an attractive target for chemotherapy. Testing this hypothesis will require potent inhibitors with favorable pharmacokinetic properties. We report that 2'-methoxyethyl oligonucleotides complementary to the telomerase RNA component diffuse across cell membranes without the need for cationic carrier lipid, inhibit telomerase, and cause telomeres to shorten. The ability of antitelomerase oligomers to enter cells without the need to add lipid will simplify preclinical studies and may suggest advantages for clinical use.
<title>Polarimetric sensor strain sensitivity in different thermal operating conditions</title> (1991)

This communication deals with the experimental verification of the change of strain sensitivity of a polarimetric fiber optic sensor with temperature. Samples of bow-tie HB fiber were submitted to tensile tests by means of a mechanical testing machine at different temperatures. The experimental results confirm that the observed variations on the strain sensitivity can be correlated to the thermal sensitivity change by means of the expansion coefficient.
Abstract 606: Inhibition of Anastomotic Intimal Hyperplasia Using a Chimeric Decoy Strategy Against NFκB and E2F in a Rabbit Model (2007)

Neointimal formation remains a major limitation after arterial reconstruction including prosthetic graft implantation. To overcome this problem, we focused on two important transcription factors, N...
HEART SOUNDS CHARACTERISTICS FROM A 3D ACCELEROMETER IN HEART FAILURE PATIENTS (2022)

Heart sounds (HS) are an important cardiac hemodynamic marker. The capability of a miniaturized three-dimensional (3D) accelerometer (AXL) present in cardiac implantable electronic devices (CIED) to detect HS in clinical setting, especially in heart failure (HF) patients (pts), has not been performed yet.
The discovery of a new structural class of cyclin-dependent kinase inhibitors, aminoimidazo[1,2-a]pyridines (2004)

The protein kinase family represents an enormous opportunity for drug development. However, the current limitation in structural diversity of kinase inhibitors has complicated efforts to identify effective treatments of diseases that involve protein kinase signaling pathways. We have identified a new structural class of protein serine/threonine kinase inhibitors comprising an aminoimidazo[1,2-a]pyridine nucleus. In this report, we describe the first successful use of this class of aza-heterocycles to generate potent inhibitors of cyclin-dependent kinases that compete with ATP for binding to a catalytic subunit of the protein. Co-crystal structures of CDK2 in complex with lead compounds reveal a unique mode of binding. Using this knowledge, a structure-based design approach directed this chemical scaffold toward generating potent and selective CDK2 inhibitors, which selectively inhibited the CDK2-dependent phosphorylation of Rb and induced caspase-3-dependent apoptosis in HCT 116 tumor cells. The discovery of this new class of ATP-site-directed protein kinase inhibitors, aminoimidazo[1,2-a]pyridines, provides the basis for a new medicinal chemistry tool to be used in the search for effective treatments of cancer and other diseases that involve protein kinase signaling pathways.