gebhart/patrepeval huggingface dataset:
Square-Root-Free QRD-LSL Adaptive Algorithm with Improved Numerical Robustness (2008)

The QR-decomposition-based least-squares lattice (QRD-LSL) algorithm is one of the most attractive choices for adaptive filters applications, mainly due to its fast convergence rate and good numerical properties. In practice, the square-root-free QRD-LSL (SRF-QRD-LSL) algorithms are frequently employed, especially when fixed- point digital signal processors (DSPs) are used for implementation. In this context, there are some major limitations regarding the large dynamic range of the algorithm's cost functions. Consequently, hard scaling operations are required, which further reduce the precision of numerical representation and lead to performance degradation. In this paper we propose a SRF-QRD-LSL algorithm based on a modified update of the cost functions, which offers improved numerical robustness. Simulations performed in fixed-point and logarithmic number system (LNS) implementation support the theoretical findings.
The electronic paper prototype with visual interaction enriched windows (2004)

The Visual Interaction Platform (VIP) is an Augmented Reality system that was designed to make better use of well-developed human skills for real world object manipulation. The platform supports several applications in which physical interaction elements are used to control virtual elements. In this demonstration, we specifically discuss two applications that were created on the VIP. The Electronic Paper (EP) prototype offers natural interactions such as sketching and handwriting and two-handed manipulation, which are especially important for applications such as architectural or industrial design. In order to combine the advantages of the EP prototype with the advantages of existing desktop applications, we have also developed and implemented the concept of Visual Interaction Enriched Windows (VIEWs), and have integrated it within the EP tool.
Comparison of response to aerosol drug delivery with mesh and jet nebulizers during non-invasive ventilation (NIV) in acute exacerbation of COPD (2017)

<b>Background:</b> Advances in aerosol technology have improved drug delivery efficiency during NIV. Clinical evaluation of the efficacy of aerosol therapy during NIV in the treatment of acute exacerbation of COPD (AE COPD) is very limited. <b>Aim:</b> To compare efficacy of bronchodilators administered via a vibrating mesh nebulizer (VMN) and jet nebulizer (JN) during NIV in patients with AE COPD. <b>Methods:</b> Prospective randomized cross-over study, included 30 patients treated with NIV for AE COPD. Patients were consented and enrolled after AECOPD stabilization (3-5 days after admission). Subjects were randomly assigned into 2 treatments arms receiving salbutamol (2.5 mg): with VMN (Aerogen Solo) and JN (Sidestream) positioned between the leak port and the non-vented oronasal mask during bi-level ventilation with a single-limb circuit. Measurements (clinical data, pulmonary function tests, arterial blood gases) were performed at baseline, 1, 2 and 4 hours after treatment. <b>Results:</b> A reduction in respiratory rate (baseline to 4h) from 21.9±1.9 to 19.3±1.4 b/min vs 22.3±2.0 to 20.8±1.64 b/min was observed; with VMN and JN, respectively; p=0.0003). Borg dyspnea score was significantly more reduced with VMN (5.9±1.1 to 4.1±1.17) than JN (6.2±1.2 to 5.2±1.2; p=0.0006). All PFTs, SpO<sub>2</sub>, PaO<sub>2</sub> and PaCO<sub>2</sub> improved in both groups, but overall changes were greater with VMN than JN, especially for FVC (110 mL vs 400 mL). <b>Conclusion:</b> Bronchodilator administration in patients with AE COPD during NIV with VMN resulted in clinically significant improvements in FVC and in Borg dyspnea score. Additional studies required to determine impact on clinical outcomes.
An Independent Assessment of the Physiological and Cognitive Effects from the X-26 TASER Device in Volunteer Human Subjects (2009)

Abstract : Exposure to the X-26 TASER was studied in 32 healthy human subjects (police academy cadets who previously volunteered for X-26 TASER exposure as part of their training). Five primary data sets were obtained: (1) blood analysis before, immediately after, and 24 hours after exposure, (2) 12-lead electrocardiogram (ECG) recordings before and after exposure, (3) respiratory function testing before, during, and after exposure, (4) psychomotor function task assessment prior to (audio stimulus) and during exposure, and (5) post-exposure interview. The data analysis of (3) is technically limited because of low confidence in the data. Hence, this report focuses on the blood chemistry analysis, ECG evaluation, psychomotor function assessment, and post-exposure interview findings.
Reconfigurable Multiband Antenna Booster Element under Metallic Environment for IoT Applications (2023)

A passive matching network cannot match a device for more than one specific scenario. For this reason, a new approach capable of matching an Internet of things (IoT) device at 698-960 MHz and 1710-2170 MHz for two different environments, free space and on top of a metallic plate, is presented. The proposed method uses an SP4T (Single Pole 4 Throw) switch to provide good impedance matching in both environments. The multiband reconfigurable matching network can mitigate the frequency shifting created by the metallic environment. To validate it, a prototype is implemented and tested in both environments. By using the reconfigurable architecture, total efficiency is maximized in both free-space and on-metal plate cases. The total efficiency is increased by 3 dB for the on-metal condition compared to a passive solution where a single matching network is used for both cases.
Reduction Clitoroplasty Via Ventral Approach (1982)

No AccessJournal of Urology1 Aug 1982Reduction Clitoroplasty Via Ventral Approach Jacob Rajfer, Richard M. Ehrlich, and Willard E. Goodwin Jacob RajferJacob Rajfer , Richard M. EhrlichRichard M. Ehrlich , and Willard E. GoodwinWillard E. Goodwin View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)52916-XAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail We describe an operative technique to reduce the enlarged clitoris that minimizes any potential damage to the dorsal neurovascular bundle of the clitoris. © 1982 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByYang J, Felsen D and Poppas D (2007) Nerve Sparing Ventral Clitoroplasty: Analysis of Clitoral Sensitivity and ViabilityJournal of Urology, VOL. 178, NO. 4S, (1598-1601), Online publication date: 1-Oct-2007.Passerini-Glazel G (2018) A New 1-Stage Procedure for Clitorovaginoplasty in Severely Masculinized Female PseudohermaproditesJournal of Urology, VOL. 142, NO. 2 Part 2, (565-568), Online publication date: 1-Aug-1989.Jones H (2018) Editorial CommentJournal of Urology, VOL. 129, NO. 5, (1026-1026), Online publication date: 1-May-1983. Volume 128Issue 2August 1982Page: 341-343 Advertisement Copyright & Permissions© 1982 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Jacob Rajfer More articles by this author Richard M. Ehrlich More articles by this author Willard E. Goodwin More articles by this author Expand All Advertisement Loading ...
What Experts Think About Prostate Cancer Management During the COVID-19 Pandemic: Report from the Advanced Prostate Cancer Consensus Conference 2021 (2022)

Patients with advanced prostate cancer (APC) may be at greater risk for severe illness, hospitalisation, or death from coronavirus disease 2019 (COVID-19) due to male gender, older age, potential immunosuppressive treatments, or comorbidities. Thus, the optimal management of APC patients during the COVID-19 pandemic is complex. In October 2021, during the Advanced Prostate Cancer Consensus Conference (APCCC) 2021, the 73 voting members of the panel members discussed and voted on 13 questions on this topic that could help clinicians make treatment choices during the pandemic. There was a consensus for full COVID-19 vaccination and booster injection in APC patients. Furthermore, the voting results indicate that the expert's treatment recommendations are influenced by the vaccination status: the COVID-19 pandemic altered management of APC patients for 70% of the panellists before the vaccination was available but only for 25% of panellists for fully vaccinated patients. Most experts (71%) were less likely to use docetaxel and abiraterone in unvaccinated patients with metastatic hormone-sensitive prostate cancer. For fully vaccinated patients with high-risk localised prostate cancer, there was a consensus (77%) to follow the usual treatment schedule, whereas in unvaccinated patients, 55% of the panel members voted for deferring radiation therapy. Finally, there was a strong consensus for the use of telemedicine for monitoring APC patients. PATIENT SUMMARY: In the Advanced Prostate Cancer Consensus Conference 2021, the panellists reached a consensus regarding the recommendation of the COVID-19 vaccine in prostate cancer patients and use of telemedicine for monitoring these patients.
Fault detection and isolation for redundant aircraft sensors (2010)

A method for failure detection and isolation for redundant aircraft sensors is presented. The outputs of the concerned sensors are involved in the computation of flight law controls, and the objective is to eliminate any perturbation before propagation in the control loop when selecting a unique flight parameter among a set (generally 3) of redundant measurements. The particular case of an oscillatory failure is investigated. The proposed method allows an accurate fault detection and isolation of erroneous sensor and computes a consolidated parameter based on the fusion of data from remaining valid sensors. The benefits of the presented method are to enhance the data fusion process with FDI techniques which improves the performance of the fusion when only few sources (less than three) are valid.
The AKT modulator A-443654 reduces α-synuclein expression and normalizes ER stress and autophagy (2021)

Accumulation of α-synuclein is a main underlying pathological feature of Parkinson's disease and α-synucleinopathies, for which lowering expression of the α-synuclein gene (SNCA) is a potential therapeutic avenue. Using a cell-based luciferase reporter of SNCA expression we performed a quantitative high-throughput screen of 155,885 compounds and identified A-443654, an inhibitor of the multiple functional kinase AKT, as a potent inhibitor of SNCA. HEK-293 cells with CAG repeat expanded ATXN2 (ATXN2-Q58 cells) have increased levels of α-synuclein. We found that A-443654 normalized levels of both SNCA mRNA and α-synuclein monomers and oligomers in ATXN2-Q58 cells. A-443654 also normalized levels of α-synuclein in fibroblasts and iPSC-derived dopaminergic neurons from a patient carrying a triplication of the SNCA gene. Analysis of autophagy and endoplasmic reticulum stress markers showed that A-443654 successfully prevented α-synuclein toxicity and restored cell function in ATXN2-Q58 cells, normalizing the levels of mTOR, LC3-II, p62, STAU1, BiP, and CHOP. A-443654 also decreased the expression of DCLK1, an inhibitor of α-synuclein lysosomal degradation. Our study identifies A-443654 and AKT inhibition as a potential strategy for reducing SNCA expression and treating Parkinson's disease pathology.
Electrical Communication Between Graphite Electrodes and Glucose Oxidase/Redox Polymer Complexes (1990)

Abstract Redox polymers can fold along the glycoproteins of glucose oxidase (MW 160,000) at low electrolyte concentrations and thereby penetrate the enzyme. Upon penetration, the distance between the redox centers of the polymer and the FADH2 centers of the reduced enzyme is reduced sufficiently for electrons to be transferred and, therefore, for the mediated electro-oxidation of glucose on conventional electrodes. At high (1M) electrolyte (NaCl) concentrations the redox polymers coil. Such coiling prevents the penetration of the enzyme by the redox polymers. Consequently, electron transfer does not take place and glucose is not electro-oxidized. When an appropriate polycationic redox polymer is covalently bound to the enzyme, the electro-oxidation of glucose occurs even at high electrolyte concentrations. Electron transfer from the enzyme's FADH2 centers to copolymers of poly(N-methyl-4-vinylpyridinium) chloride with either poly(vinylferrocene), E° = 0.25V (SCE), or with poly(4-vinylpyridine) complexes of Os(bpy)2Cl, E° = 0.25V (SCE), or of Os(4,4′-dimethylbpy)2Cl, E° = 0.15V (SCE) is rapid. The polycationic poly(4-vinylpyridine) complex of Os(bpy)2Cl can be covalently bound to glucose oxidase by preparing the terpolymer with 4-aminostyrene, diazotization and reaction of the diazonium cations with tyrosine or tryptophane residues of the enzyme. Glucose electrodes made with the redox polymer modified enzyme are relatively stable and sensitive. Furthermore, simple and fast amperometric glucose electrodes can be made by adsorbing either non-quaternized or quaternized poly(vinylpyridine) complexes of [Os(bipyridine)2Cl]2+ (MW 300,000) on graphite, and adsorbing on these polymer films glucose oxidase. These electrodes do not require diffusing redox mediators or membranes to contain the enzyme and the redox polymer. The redox polymer is shown to electrically “wire” the enzyme's redox centers to the electrode. The glucose response of the electrodes is faster than 1 sec; their current increases linearly with glucose concentration through the 0–10 mM range. At 60 mM glucose, their current density is about 20 μA/cm2.
A Discontinuous Galerkin Time Domain Solver with Generalized Dispersion Model and its Application to the Analysis of Thin Pixelized Optical Metasurfaces (2020)

In order to efficiently analyze planar photonic devices, we propose a discontinuous Galerkin time domain (DGTD) method with a generalized dispersive material (GDM) model. By integrating the GDM model into a full-wave DGTD formulation, we develop a general framework that includes a universal model for the analysis of arbitrary dispersive materials. As an example application, we utilize the new DGTD-GDM solver to analyze the response of a thin pixelized metasurface. The metasurface's optical responses are computed and compared to results obtained using CST, which provides validation of the efficiency improvement as well as accuracy of the proposed algorithm.
Model-based orientation-independent 3-D machine vision techniques (1988)

Orientation-dependent techniques for the identification of a three-dimensional (3-D) object by a machine vision system are represented in parts. In the first part, the data consist of intensity images of polyhedral objects obtained by a single camera, while in the second part, the data consist of range images of curved objects obtained by a laser scanner. In both cases, the attributed graph representation of the 3-D object surface is used to drive the respective algorithm. In this representation, a graph node represents a surface path and a link, the adjacency between two patches. The attributes assigned to nodes are moment invariants of the corresponding face for polyhedral objects. For range images, the Gaussian curvature is used as a segmentation criterion for providing symbolic shape attributes. Identification is achieved by an efficient graph-matching algorithm used to match the graph obtained from the data to a subgraph of one of the model graphs stored in the computer memory.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Role of the support and reaction conditions on the vapor-phase deoxygenation of M-cresol over Pt/C and Pt/TiO2 catalysts (2016)

The catalytic deoxygenation of biomass fast pyrolysis vapors offers a promising route for the sustainable production of liquid transportation fuels. However, a clear understanding of the mechanistic details involved in this process has yet to be achieved, and questions remain regarding the role of the catalyst support and the influence of reaction conditions. In order to gain insight into these questions, the deoxygenation of m-cresol was investigated over Pt/C and Pt/TiO2 catalysts using experimental and computational techniques. The performance of each catalyst was evaluated in a packed-bed reactor under two conditions (523 K, 2.0 MPa and 623 K, 0.5 MPa), and the energetics of the ring hydrogenation, direct deoxygenation, and tautomerization mechanisms were calculated over hydrogen-covered Pt(111) and oxygen vacancies on the surface of TiO2(101). Over Pt(111), ring hydrogenation to 3-methylcyclohexanone and 3-methylcyclohexanol was found to be the most energetically favorable pathway. Over TiO2(101), ta...
Anomalous polarization switching in organic ferroelectric field effect transistors (2007)

The authors demonstrate organic ferroelectric field effect transistors using poly(vinylidene fluoride-trifluoroethylene) as dielectric in bottom common gate and patterned gate devices. Drain current hysteresis is resulted from the dipole switching at channel region due to gate-source bias. For common gate device, an additional anomalous polarization switching is observed due to gate-drain bias. This switching has no effect on the hysteresis direction yet incurs a strong peak in the off drain current leading to unstable and uncontrollable off state in memory device. Reduction of gate-drain overlapping using patterned metal gate shows diminishing the anomalous switching hence improves performance of the ferroelectric transistors.
The combination of milatuzumab, a humanized anti‐CD74 antibody, and veltuzumab, a humanized anti‐CD20 antibody, demonstrates activity in patients with relapsed and refractory B‐cell non‐Hodgkin lymphoma (2015)

As a result of the anti-tumour activity observed in vitro and in vivo with combined anti-CD20 and anti-CD74 antibodies, we initiated a phase I/II trial of veltuzumab and milatuzumab in patients with relapsed or refractory B-cell non-Hodgkin lymphoma (NHL). Patients received an induction of veltuzumab 200 mg/m(2) weekly combined with escalating doses of milatuzumab at 8, 16 and 20 mg/kg weekly for 4 weeks. Patients without disease progression could receive an extended induction with treatment on weeks 12, 20, 28 and 36. A total of 35 patients enrolled on the study. Median age was 63 years, median number of prior therapies was 3, and 63% of patients were rituximab refractory. No dose-limiting toxicities were observed in the phase I study. Related grade 3-4 toxicities included lymphopenia, leucopenia, neutropenia, anaemia, infusion reactions, hyperglycaemia, fatigue and atrial tachycardia. Median weeks of therapy was 12 and 29% of patients completed all 36 weeks of therapy. The overall response rate was 24%, median duration of response was 12 months, and responses were observed at all dose levels and in 50% of patients refractory to rituximab. Combination therapy with veltuzumab and milatuzumab demonstrated activity in a population of heavily pre-treated patients with relapsed or refractory indolent NHL.
Generating Residue Number System Bases (2021)

Residue number systems provide efficient techniques for speeding up calculations and/or protecting against side channel attacks when used in the context of cryptographic engineering. One of the interests of such systems is their scalability, as the existence of large bases for some specialized systems is often an open question. In this paper, we present highly optimized methods for generating large bases for residue number systems and, in some cases, the largest possible bases. We show their efficiency by demonstrating their improvement over the state-of-the-art bases reported in the literature. This work make it possible to address the problem of the scalability issue of finding new bases for a specific system that arises whenever a parameter changes, and possibly open new application avenues.
Effects of Novel Manufacturing Technology on Blood and Dialysate Flow Distribution in a New Low Flux “α Polysulfone” Hemodialyzer (2003)

The main target for low flux hemodialyzers is an efficient low molecular weight solutes clearance. Such efficiency is largely dependent on the optimization of diffusion between blood and dialysis solution. The diffusion process can be impaired if there is a mismatch between blood and dialysate flow distribution in the dialyzer. Thus optimized flow distribution both in the blood and dialysate compartment becomes quintessential for the maximal efficiency of the diffusion process within the hemodialyzer. The present paper describes the distribution of the blood and dialysate flows in a new low flux polysulfone hollow fiber hemodialyzer characterized by a specific undulation of the fibers and a new cutting technology of the fibers for an improved micro-flow condition in the blood compartment headers. Twelve Diacap alpha Polysulfone LO PS 15 (1.5 sqm) (B. Braun Medizintechnologie, Melsungen Germany) were employed for the study. Six were analyzed in vitro and six were studied in vivo. Blood flow distribution was studied in vitro by dye injection in the blood compartment during experimental extracorporeal circulation utilizing human blood with hematocrit adjusted at 33%. Sequential images were obtained with a helical scanner in a fixed longitudinal section of the dialyzer 1 cm thick. Average and regional blood flow velocities were measured utilizing the reconstructed imaging sequence. The method allowed the calculation of single fiber blood flow (SF Qb) and the mass transfer zone (MTR) definition in digitally subtracted images. The patterns 20-10 and 40-30 were utilized. The same technology was used to evaluate flow distribution in the dialysate compartment after dye injection in the Hansen's connector. Regional dialysate flow was calculated in central and peripheral sample areas of 1 cm2. Six in vivo hemodialysis treatments on patients with end stage renal disease were performed at three different blood flow rates (250-350 and 450 ml/min) in order to measure urea, creatinine and phosphate clearance. Macroscopic and densitometrical analysis revealed that flow distribution was homogeneous in the blood compartment while in the dialysate compartment a slight difference between the peripheral and central regions in terms of flow velocity was observed. This however was not generating channeling phenomena. Urea creatinine and phosphate clearances were remarkably high and so were the Kt/V observed in all sessions, especially in relation to the studied blood flows. In conclusion, a significant blood to dialysate flow match with optimized countercurrent flow condition was observed in the studied hollow fiber hemodialyzers. Such optimization might be due both to the improved dialyzer design at the level of the blood header and to the specific fiber undulation that prevents dialysate channeling.
Asymmetric Catalytic Coupling of Organoboranes, Alkynes, and Imines with a Removable (Trialkylsilyloxy)ethyl Group — Direct Access to Enantiomerically Pure Primary Allylic Amines. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.