gebhart/patrepeval huggingface dataset:
Prototyping and Experimentation of a Closed-Loop Wireless Power Transmission with Channel Acquisition and Waveform Optimization (2017)

A systematic design of adaptive waveform for Wireless Power Transfer (WPT) has recently been proposed and shown through simulations to lead to significant performance benefits compared to traditional non-adaptive and heuristic waveforms. In this study, we design the first prototype of a closed-loop wireless power transfer system with adaptive waveform optimization based on Channel State Information acquisition. The prototype consists of three important blocks, namely the channel estimator, the waveform optimizer, and the energy harvester. Software Defined Radio (SDR) prototyping tools are used to implement a wireless power transmitter and a channel estimator, and a voltage doubler rectenna is designed to work as an energy harvester. A channel adaptive waveform with 8 sinewaves is shown through experiments to improve the average harvested DC power at the rectenna output by 9.8% to 36.8% over a non-adaptive design with the same number of sinewaves.
Surface effects in preparation of cell‐size liposomes (1984)

Effects of surface type and area were shown to be important in the yield of cell‐size liposomes, but not in determining their size. The liposomes were prepared by dissolving lipids in a chloroform‐methanol solution and then evaporating the solvent under nitrogen in the presence of glass beads. After evaporation of the solvent, which was rapid due to the increased surface area, the dried lipids were then swollen in water at high temperatures (higher than the phase transition of the lipids), which led to formation of giant liposomes. The number of liposomes prepared in the presence of pyrex glass beads, which increase more than 100‐times the surface area of lipid‐glass contact, is more than 5‐times larger than in the control experiments without glass beads. The yield of liposomes in the presence of another type of glass bead was almost the same as in the control experiments. These effects may be due to long‐ and short‐range intermolecular interactions in the glass/water/lipid system.
Improved Spectral Efficiency in STAR-RIS Aided Uplink Communication Using Rate Splitting Multiple Access (2023)

In this paper, a phase-shift coupled simultaneous transmitting/refracting and reflecting reconfigurable intelligent surface (STAR-RIS)-aided uplink (UL) rate-splitting multiple access (RSMA) system is investigated to achieve improved spectral efficiency. The considered UL RSMA system splits the rate for each user by dividing their message into multiple sub-messages and these sub-messages are transmitted to the base station (BS) via STAR-RIS as direct link between BS and user is absent. In particular, we formulate a resource allocation design problem which aim to maximize the overall rate-throughput of the considered system under the joint optimization of power allocation, decoding order, user-fairness and beamforming design at STAR-RIS for various operating modes of STAR-RIS modes, which is mixed- integer non-linear programming (MINLP). To solve the formulated non-convex complex problem, we first transform the original sum-rate maximization into its simplified form and then solved it using an alternating optimization algorithm where the sub-problems of power allocation and beamforming design under given decoding order are solved alternatively using general convex approximation and fractional programming approaches. Numerical simulation and computational complexity analysis validate that the proposed solution attains fast convergence. Moreover, the proposed RSMA scheme in STAR-RIS aided UL system outperforms the conventional nonorthogonal multiple access and orthogonal multiple access schemes in terms of overall rate-throughput and user-fairness.
Equation-of-motion coupled-cluster methods for ionized states with an approximate treatment of triple excitations (2005)

The accuracy of geometries and harmonic vibrational frequencies is evaluated for two equation-of-motion ionization potential coupled-cluster methods including CC3 and CCSDT-3 triples corrections. The first two Sigma states and first Pi state of the N2 +, CO+, CN, and BO diatomic radicals are studied. The calculations show a tendency for the CC3 variant to overestimate the bond lengths and to underestimate the vibrational frequencies, while the CCSDT-3 variant seems to be more reliable. It is also demonstrated that the accuracy of such methods is comparable to sophisticated traditional multireference approaches and the full configuration interaction method.
ChemInform Abstract: Two New Methods to Form Substituted Oligoethylene Glycols. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Genetic dissection of the biosynthetic route to gentamicin A2by heterologous expression of its minimal gene set (2008)

Since the first use of streptomycin as an effective antibiotic drug in the treatment of tuberculosis, aminoglycoside antibiotics have been widely used against a variety of bacterial infections for over six decades. However, the pathways for aminoglycoside biosynthesis still remain unclear, mainly because of difficulty in genetic manipulation of actinomycetes producing this class of antibiotics. Gentamicin belongs to the group of 4,6-disubstituted aminoglycosides containing a characteristic core aminocyclitol moiety, 2-deoxystreptamine (2-DOS), and the recent discovery of its biosynthetic gene cluster in Micromonospora echinospora has enabled us to decipher its biosynthetic pathway. To determine the minimal set of genes and their functions for the generation of gentamicin A(2), the first pseudotrisaccharide intermediate in the biosynthetic pathway for the gentamicin complex, various sets of candidate genes from M. echinospora and other related aminoglycoside-producing strains were introduced into a nonaminoglycoside producing strain of Streptomyces venezuelae. Heterologous expression of different combinations of putative 2-DOS biosynthetic genes revealed that a subset, gtmB-gtmA-gacH, is responsible for the biosynthesis of this core aminocyclitol moiety of gentamicin. Expression of gtmG together with gtmB-gtmA-gacH led to production of 2'-N-acetylparomamine, demonstrating that GtmG acts as a glycosyltransferase that adds N-acetyl-d-glucosamine (GLcNA) to 2-DOS. Expression of gtmM in a 2'-N-acetylparomamine-producing recombinant S. venezuelae strain generated paromamine. Expression of gtmE in an engineered paromamine-producing strain of S. venezuelae successfully generated gentamicin A(2), indicating that GtmE is another glycosyltransferase that attaches d-xylose to paromamine. These results represent in vivo evidence elucidating the complete biosynthetic pathway of the pseudotrisaccharide aminoglycoside.
CPW Fed Substrate Integrated Waveguide Packaged Slot Array Antenna for K band Automotive Radar Applications (2019)

This paper presents a high gain planar Substrate Integrated Waveguide slot antenna array which is fed through an optimized Coplanar Waveguide (CPW)-to-SIW transition. The design offers promising response for applications in K band automotive radars at 24 GHz. A back-to-back CPW to SIW transition has been analyzed followed by integration of the transition with the slot array antenna. The effect of aluminum packaging has also been simulated and it has been observed that the gain is slightly increased from 9.4 dBi to 10.9 dBi by adding aluminum walls.
Full-Field Pupillary Light Responses, Luminance Thresholds, and Light Discomfort Thresholds inCEP290Leber Congenital Amaurosis Patients (2015)

The FST thresholds and transient PLRs were cone mediated in our cohort LCA-CEP290 patients. Rod-mediated PLRs were undetectable, whereas melanopsin-mediated sustained responses were detected in all patients, suggesting a relative preservation of inner-retina function. The LDT elevations for the patients are somewhat paradoxical, given their subjective perception of photoaversion. Relative aversion to short-wavelength light suggests influence from melanopsin on LDTs in these patients.
Multimodal, multiplex Raman spectrometry for detection of ethanol in blood and tissue (2004)

We investigate the application of static, multimodal, multiplex spectrometers to the detection of the Raman spectrum of ethanol in blood and tissue. These spectrometers are optimized for use with weak, incoherent sources, and enable relatively high sensitivity in a completely integrated system.
Managing Geologic CO2 Storage with Pre-injection Brine Production in Tandem Reservoirs (2017)

We present an approach for managing geologic CO2 storage using wells that serve three sequential purposes (1) characterization and monitoring, (2) brine production, and (3) CO2 injection. Two reservoirs are deployed in tandem: (1) a CO2-storage reservoir and (2) a brine-storage reservoir. This approach provides data that can be analyzed prior to CO2 injection, enabling proactive reservoir management, which reduces cost and risk. We analyze a range of brine-disposition options, including 100% reinjection in a nearby brine-storage reservoir and cases where a portion of the produced brine is used to generate water, with the residual brine reinjected in the nearby reservoir. We also consider the option of time-shifting the parasitic load of brine production and injection, so that those operations can utilize excess energy from electric grids during periods of over-generation.
Capacity bounds and robustness in multipath networks (2016)

The recent developments of multipath data transport protocols such as Multipath TCP allow end-systems to explore and share available resources within networks. Through dynamic load balancing over subflows these protocols ensure high levels of robustness to network failures and traffic overloads. In
Methodologies to mitigate package induced stresses in the BEOL (2016)

In this paper we will study different approaches in order to reduce the risk of failures in the Back-End-of-Line (BEOL) going from the reinforcement of the BEOL itself to the design of the under bump pad with soft and stiff materials. This work is done by combining Finite Element Models (FEM) and the analysis of failures after a mechanical shear tests of copper pillars with different under bump pad designs. A dedicated test chip with a BEOL of 4 metal layers is designed and built with a minimum pitch of 90 nm and a metal thickness aspect ratio of 1 for the first two metal layers where advanced low-k materials with k ≤ 2.4 are used. The impact of via densities is assessed. The experimental shear test results demonstrate that a thick passivation, although reduces the stresses in the lower layers of the BEOL, may induce early failures due to a crack in the passivation that propagate towards lower layers of BEOL. This crack growing process can be explained by the numerical modeling where it is found that there is a high residual stress in the base of the aluminum pad due to the deposition of the passivation layer on top of the aluminum.
Large strain actuation in polypyrrole actuators (2004)

A typical limitation of polypyrrole based conducting polymer actuators is the low achievable active linear strains (2 % recoverable at 10 MPa, 7 % max) that these active materials exhibit when activated in a common propylene carbonate / tetraethylammonium hexafluorophosphate electrolyte. Mammalian skeletal muscle, on the other hand, exhibits large recoverable linear strains on the order of 20%. Such large linear strains are desirable for applications in life-like robotics, artificial prostheses or medical devices. We report herein the measurement of recoverable linear strains in excess of 14 % at 2.5 MPa (20 % max) for polypyrrole activated in the 1-butyl-3-methyl imidazolium tetrafluoroborate liquid salt electrolyte. This advancement in conducting polymer actuator technology will impact many engineering fields, where a lightweight, large displacement actuator is needed. Benefits and trade offs of utilizing ionic liquid electrolytes for higher performance polypyrrole actuation are discussed.
Imidazoquinoline-Conjugated Degradable Coacervate Conjugate for Local Cancer Immunotherapy (2020)

Strategies that can reduce the harmful side effects of potent immunomodulatory drugs are in high demand to facilitate clinical translation of the newest generation of immunotherapy. Indeed, uncontrolled triggering of the immune system can lead to life-threatening cascade reactions, such as e.g. cytokine storm. In particular, drug formulations that combine simplicity and degradability are of formidable relevance. Imidazoquinolines are an excellent example of such small molecule immunomodulatory drugs that exhibit in unformulated form a highly undesirable pharmacokinetic profile. Imidazoquinolines are potent inducers of type I interferons that are of great interest in the context of anticancer and antiviral therapy through triggering of Toll like receptors 7 and 8. In this work we aimed to alter the pharmacokinetic profile of imidazoquinolines using a simple, yet efficient, strategy that holds high potential for clinical translation. Hereto, we conjugated an imidazoquinoline to the backbone of poly(aspartate) and further formulated this into a degradable coacervate through complex coacervation with a nontoxic degradable polycation. The intrinsic TLR activity of the imidazoquinoline was well preserved and our formulation strategy offered spatial control over its biological activity in vivo.
Enrichment of a fraction toxic to guinea-pigs from Pachystigma pygmaeum (Schltr.) Robyns. (1985)

Pachystigma pygmaeum is one of several species of rubiaceous plants which cause delayed heart failure among ruminants after their ingestion at relatively high doses. Using guinea-pigs for toxicity determinations, we were able to separate and enrich a toxic fraction from a fermentation extract of the plant material by countercurrent distribution. It contained virtually no potassium salts, passed through a 500 dalton selective membrane, exhibited lability under acid conditions and was toxic at 1 g/kg per os, with a delayed response of 3-4 days.
Design of Electrostatic Aberration Correctors for Scanning Transmission Electron Microscopy (2023)

In a scanning transmission electron microscope (STEM), producing a high-resolution image generally requires an electron beam focused to the smallest point possible. However, the magnetic lenses used to focus the beam are unavoidably imperfect, introducing aberrations that limit resolution. Modern STEMs overcome this by using hardware aberration correctors comprised of many multipole lenses, but these devices are complex, expensive, and can be difficult to tune. We demonstrate a design for an electrostatic phase plate that can act as an aberration corrector. The corrector is comprised of annular segments, each of which is an independent two-terminal device that can apply a constant or ramped phase shift to a portion of the electron beam. We show the improvement in image resolution using an electrostatic corrector. Engineering criteria impose that much of the beam within the probe-forming aperture be blocked by support bars, leading to large probe tails for the corrected probe that sample the specimen beyond the central lobe. We also show how this device can be used to create other STEM beam profiles such as vortex beams and beams with a high degree of phase diversity, which improve information transfer in ptychographic reconstructions.
Ligand-Free Suzuki–Miyaura Coupling Reactions Using an Inexpensive Aqueous Palladium Source: A Synthetic and Computational Exercise for the Undergraduate Organic Chemistry Laboratory (2014)

An inexpensive procedure for introducing the Suzuki–Miyaura coupling reaction into a high-enrollment undergraduate organic chemistry laboratory course is described. The procedure employs an aqueous palladium solution as the catalyst and a range of para-substituted aryl bromides and arylboronic acids as substrates. The coupling reactions proceed rapidly at room temperature using standard glassware and do not require ligands, an inert atmosphere, or specialized equipment. Computational chemistry is used to explore the molecular and electronic structures of typical starting materials and products of the Suzuki–Miyaura coupling.
Evolution dynamics of Helmholtz Bessel beams (2013)

We study the dynamics of accelerating Bessel beams and their corresponding apodized version. Presenting a closed analytical form for the intensity profile, we investigate the contribution of evanescent fields during the evolution for both cases.
Springback prediction of sheet metals using improved material models (2017)

Accurate springback prediction by finite element simulation requires the use of accurate material models to describe the deformation behavior of the sheet metal that are properly calibrated with data from mechanical property tests. In this work, in-plane biaxial tensile tests of cruciform specimens were conducted to obtain the yield loci of a 980 MPa grade multiphase steel (MP980). Yield criteria including the Hill48, Barlat89 and Barlat2000 functions were applied and compared to model the yield behavior of MP980. Tension-compression tests were conducted to obtain true stress vs. true strain curves under loading and reverse loading paths in order to determine parameters of the Yoshida-Uemori nonlinear dynamic hardening model. Finite element simulations with LS-DYNA were performed to predict springback behavior for comparison with measurements of stamped U-shaped specimens. It is shown that the selection of accurate yield criteria (e.g. Barlat2000 with order of 8) combined with the Y-U model increases the accuracy of springback prediction of the side-wall curl for the U-shaped specimens.
Immunohistochemistry for the imprinted gene product IPL/PHLDA2 for facilitating the differential diagnosis of complete hydatidiform mole. (2004)

Immunohistochemistry for PHLDA2 serves as a practical and reliable diagnostic marker for the discrimination of complete mole from partial mole and hydropic abortion. Since the immunohistochemical diagnosis of complete mole is based on a negative result, absence of staining, the use of both markers (PHLDA2 and p57KIP2) together could increase the level of confidence when making this prognostically important distinction.
Fucoidan Promotes Early Step of Cardiac Differentiation from Human Embryonic Stem Cells and Long-Term Maintenance of Beating Areas (2013)

Somatic stem cells require specific niches and three-dimensional scaffolds provide ways to mimic this microenvironment. Here, we studied a scaffold based on Fucoidan, a sulfated polysaccharide known to influence morphogen gradients during embryonic development, to support human embryonic stem cells (hESCs) differentiation toward the cardiac lineage. A macroporous (pore 200 μm) Fucoidan scaffold was selected to support hESCs attachment and proliferation. Using a protocol based on the cardiogenic morphogen bone morphogenic protein 2 (BMP2) and transforming growth factor (TGFβ) followed by tumor necrosis factor (TNFα), an effector of cardiopoietic priming, we examined the cardiac differentiation in the scaffold compared to culture dishes and embryoid bodies (EBs). At day 8, Fucoidan scaffolds supported a significantly higher expression of the 3 genes encoding for transcription factors marking the early step of embryonic cardiac differentiation NKX2.5 (p<0.05), MEF2C (p<0.01), and GATA4 (p<0.01), confirmed by flow cytometry analysis for MEF2C and NKX2.5. The ability of Fucoidan scaffolds to locally concentrate and slowly release TGFβ and TNFα was confirmed by Luminex technology. We also found that Fucoidan scaffolds supported the late stage of embryonic cardiac differentiation marked by a significantly higher atrial natriuretic factor (ANF) expression (p<0.001), although only rare beating areas were observed. We postulated that absence of mechanical stress in the soft hydrogel impaired sarcomere formation, as confirmed by molecular analysis of the cardiac muscle myosin MYH6 and immunohistological staining of sarcomeric α-actinin. Nevertheless, Fucoidan scaffolds contributed to the development of thin filaments connecting beating areas through promotion of smooth muscle cells, thus enabling maintenance of beating areas for up to 6 months. In conclusion, Fucoidan scaffolds appear as a very promising biomaterial to control cardiac differentiation from hESCs that could be further combined with mechanical stress to promote sarcomere formation at terminal stages of differentiation.
TLR9 Is Critical for Glioma Stem Cell Maintenance and Targeting (2014)

Understanding supports for cancer stem-like cells in malignant glioma may suggest therapeutic strategies for their elimination. Here, we show that the Toll-like receptor TLR9 is elevated in glioma stem-like cells (GSC) in which it contributes to glioma growth. TLR9 overexpression is regulated by STAT3, which is required for GSC maintenance. Stimulation of TLR9 with a CpG ligand (CpG ODN) promoted GSC growth, whereas silencing TLR9 expression abrogated GSC development. CpG-ODN treatment induced Frizzled4-dependent activation of JAK2, thereby activating STAT3. Targeted delivery of siRNA into GSC was achieved via TLR9 using CpG-siRNA conjugates. Through local or systemic treatment, administration of CpG-Stat3 siRNA to silence STAT3 in vivo reduced GSC along with glioma growth. Our findings identify TLR9 as a functional marker for GSC and a target for the delivery of efficacious therapeutics for glioma treatment. Cancer Res; 74(18); 5218-28. ©2014 AACR.
ChemInform Abstract: Oleum and Sulfuric Acid as Reaction Media: Structural Features and Thermal Behavior of Ln2[W2O3(SO4)6] (Ln: Sm—Gd, Ho), Ln2Nb2O2(SO4)3‐ [H(SO4)2]2 (Ln: Y, Ce—Nd, Sm—Er), Sm2Nb2O2(SO4)5 (S2O7), and M2Nb4O5(SO4)8 (M: Bi, Eu). (2011)

Abstract The title compounds are solvothermally prepared and structurally characterized by single crystal XRD.
Vapor Pressure Characterization of Several Phenolics and Polyhydric Compounds by Knudsen Effusion Method (2006)

The vapor pressures of anthracene, catechol, hydroquinone, caffeic acid, ferulic acid, gentisic acid, and myoinositol have been measured by an isothermal Knudsen effusion method. The vapor pressure correlations fit to the following linear equations: anthracene, ln(p/Pa) = (31.886 ± 0.440) to (11496 ± 149) T/K (from 320 K to 354 K); catechol, ln(p/Pa) = (31.05 ± 0.18) to (9618 ± 56) T/K (from 295 K to 310 K); hydroquinone, ln(p/Pa) = (34.595 ± 0.455) to (12102 ± 150) T/K (from 327 K to 348 K); caffeic acid, ln(p/Pa) = (45.122 ± 1.320) to (20466 ± 550) T/K (from 409 K to 424 K); ferulic acid, ln(p/Pa) = (39.454 ± 0.402) to (15925 ± 153) T/K (from 369 K to 390 K); gentisic acid, ln(p/Pa) = (36.297 ± 0.454) to (14184 ± 168) T/K (from 362 K to 379 K); and myoinositol, ln(p/Pa) = (44.366 ± 0.702) to (20931 ± 315) T/K (from 438 K to 458 K). The sublimation enthalpies and entropies of these samples are calculated.