gebhart/patrepeval huggingface dataset:
Nanocomposites Prepared by Twin Polymerization of a Single‐Source Monomer (2006)

A common source: In a novel twin polymerization, a single monomer is transformed into an organic–inorganic nanocomposite. For example, tetrafurfuryloxysilane polymerizes to form a dense interpenetrating network of poly(furfuryl alcohol) and SiO2 (see picture). Nanoporous silicate, and potentially other metal oxides, can be obtained when the organic components are removed. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z504327_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
The Fock-State Laser: Macroscopic Quantum States of Light Based on Deep Strong Light-Matter Coupling (2021)

We show that coupled light-matter systems reaching the deep strong coupling regime can be coupled to gain media to form novel types of lasers emitting macroscopic quantum states of light, e.g. many-photon Fock states.
Intracellular Proadrenomedullin-Derived Peptides Decorate the Microtubules and Contribute to Cytoskeleton Function (2008)

Adrenomedullin (AM) and proadrenomedullin N-terminal 20 peptide (PAMP) are secretory hormones, but it is not unusual to find them in intracellular compartments. Using yeast-2 hybrid technology, we found interactions between AM and several microtubule-associated proteins (MAPs), and between PAMP and tubulin. Expression of fluorescent-tagged AM and PAMP as well as immunofluorescence for the native peptides showed a complete decoration of the microtubules and colocalization with other MAPs. PAMP, but not AM, bound to tubulin in vitro and destabilized tubulin polymerization. Down-regulation of the gene coding for both AM and PAMP through small interfering RNA technology resulted in morphological changes, microtubule stabilization, increase in posttranslational modifications of tubulin such as acetylation and detyrosination, reduction in cell motility, and partial arrest at the G2 phase of the cell cycle, when compared with cells transfected with the same vector carrying a scrambled sequence. These results show that PAMP is a novel MAP, whereas AM may be exerting more subtle effects in regulating cytoskeleton function.
Assessing Urine Human Papillomavirus Polymerase Chain Reaction Testing As a Tool for Screening Anal HPV Infection in HIV-Positive MSM (2012)

Multiple types of human papillomavirus (HPV) are responsible for most cervical cancers but also cause anal cancers-especially in HIV-positive patients. Furthermore, men who have sex with men (MSM) are twice as likely to develop anal cancers as non-MSM. A simple screening test for HPV infection would be useful in these patients. The aim of our study was to evaluate the detection of HPV by real-time polymerase chain reaction (PCR) in urine as a marker of anal infection in MSM. The study included 52 HIV-positive MSM treated at Amiens University Hospital (Amiens, France). After obtaining informed consent, we performed an anal swab and gathered 10 mL of first-void urine. Samples were extracted and amplified in a real-time PCR. Genotypes were determined with a PapilloCheck(®) system (Greiner Bio-One, Frickenhausen, Germany). The anal test was the gold standard for calculating the characteristics of the urine test. The sensitivity of the urine test for diagnosing anal HPV infection was 15%, the specificity was 66%, the positive predictive value was 87.5%, and negative predictive value was 4.5%. The prevalence of anal HPV infection in the study population was 94%. Genotype 42 was the most common. The anal HPV viral load was significantly lower in men in a stable relationship than in single men. However, there was no statistically significant relationship between anal viral load and anal intraepithelial lesions. We conclude that urine-based HPV is a poor predictor of anal HPV infection in HIV-positive MSM.
NAD+/NADH Tethering on MWNTs-Bucky Papers for Glucose Dehydrogenase-Based Anodes (2014)

Reagentless and non-reagentless nicotinamide adenine dinucleotide (NAD+)-dependent glucose dehydrogenase (GDH) bioanodes integrating multiwalled nanotubes (WMNTs)-bucky papers are introduced in this study. The NAD+ was tethered by pyrene butanoic acid succinimidyl ester (PBSE) to the wall of the carbonic MWNTs composing the bucky paper by π-π stacking interactions. The designs have been evaluated electrochemically and by X-ray spectroscopy. The electrodes have been assembled to a quasi-2D microfluidic system with capillary driven flow. Michaelis-Menten analysis on CMN-MG-PBSE-NAD+-GDH, reagentless bioanode, in an electrolytic cell shows a limiting current and constant of IMax = 3.252 ± 0.134 mA.cm−2 and KM = 48.3 ± 4.6 mM at 4°C, and IMax = 2.568 ± 0.085 mA.cm−2 and KM = 13.6 ± 1.8 mM at 25°C for 0.1 M glucose. Results demonstrate the enzymatic system, in non-reagentless and reagentless bioanode, has an extraordinary current density generation. In the reagentless bioanode design, the enzyme and its cofactor are highly catalytically active, and the design can be feasible integrated into biofuel cell assembly and later used as a power source for small portable devices.
Message passing-based link configuration in short range millimeter wave systems (2020)

Millimeter wave (mmWave) communication in typical wearable and data center settings is short range. As the distance between the transmitter and the receiver in short range scenarios can be comparable to the length of the antenna arrays, the common far field approximation for the channel may not be applicable. As a result, dictionaries that result in a sparse channel representation in the far field setting may not be appropriate for short distances. In this paper, we develop a novel framework to exploit the structure in short range mmWave channels. The proposed method splits the channel into several subchannels for which the far field approximation can be applied. Then, the structure within and across different subchannels is leveraged using message passing. We show how information about the antenna array geometry can be used to design message passing factors that incorporate structure across successive subchannels. Simulation results indicate that our framework can be used to achieve better beam alignment with fewer channel measurements when compared to standard compressed sensing-based techniques that do not exploit structure across subchannels.
ChemInform Abstract: Synthesis, Characterization, and Reactivity of the Meridional Isomers of Triphenylmethylphosphonium Triiodotricarbonylruthenate(II) and Triphenylmethylphosphonium Hexaiodotetracarbonyldiruthenate(II). (1987)

Abstract (I), synthesized via a modified literature method, reacts with a phosphonium iodide to yield the complex salts (II) or (III) depending on the reaction conditions.
T-Cell Depleted PBSCT Mitigates Acute GVHD, but Preserves Protective Chronic GVHD. Long Term Follow up of 138 Patients. (2005)

Abstract Between 1997 and 2004, 138 patients with hematological malignancies had an HLA-identical sibling peripheral blood stem cell transplant (PBSCT). Preparative regimen was TBI (12–13.6Gy), cyclophosphamide 120mg/kg +/− fludarabine 125mg/m2. T-cell dose was adjusted to 0.2-1 x 105 CD3+ cells/kg. CD34 dose was 2.7 – 15.9 x 106/kg (median 5.9). Patients without ≥ grade 2 acute GVHD received 1 or 2 donor lymphocyte infusions (DLI) of 107 CD3+ cells/kg between days 45 and 100. For GVHD prophylaxis, all patients received cyclosporine (CSA) following the DLI for a minimum of 6 months. In addition 72 patients received CSA in the first 6 weeks post PBSCT and 66 received no CSA immediately post-transplant. Patients were aged between 10–56 (median 34 years). Seventy-seven patients with CML-CP (42), acute leukemia in first remission (22) or MDS RA (10) were designated as standard risk (SR) for transplant outcome. Sixty-one patients with more advance or refractory disease were designated as high risk (HR) for transplant outcome. Seven patients, distributed in both groups had CLL, NHL, MM and CMML. Overall survival, relapse and TRM were 58 ± 4.5%, 40.2 ± 5.5% and 18.4 ± 3.4% respectively after a median follow up of 4 years. Twenty-two patients did not receive DLI, 70 received one and 46 received two DLI. Twenty-three patients had TRM, 2 from graft failure, 5 from acute or chronic GVHD. Fifty two (37%) developed ≥ grade II, and 21 (15%) patients grade III-IV acute GVHD. Forty two (30%) had limited and 30 (22%) extensive chronic GVHD. In univariate Kaplan-Meier analyses standard risk disease, cGVHD, single DLI and day 30 lymphocyte count (LC30) above median, favorably affected overall survival (DLI p=0.002; LC30 p=0.0002, all other variables p&amp;lt;0.0001). Risk status was the strongest factor predicting relapse (28.8 ± 8% and 58.4 ± 7% in SR and HR patients respectively p&amp;lt;0.0001). Fludarabine, degree of T-cell depletion, age, cyclosporine schedule and CD34 dose were not significant. In a Cox regression analysis, only cGVHD (RR, 4.268; p=0.001; 95% CI=1.77–10.25) and standard risk (RR, 0.146; p&amp;lt;0.001; 95%CI=0.06–0.35) remained as independent predictive factors for outcome (Figure A). On landmark analysis after day +120, cGVHD was associated with better OS (p&amp;lt;0.0001) and DFS (p=0.0006) (Figure B), and relapse (21.7± 6% and 51.5 ± 11% in patients with and without cGVHD p= 0.002). Aggressive T-cell depletion, combined with relatively high doses of CD34+ cells had proven to be a key strategy to minimize TRM and severe aGVHD. Similar to unmanipulated PBSCT this approach appears to provide a protective effect of chronic GVHD, but with low late mortality. Figure Figure
Lasing Dynamics of Optically-Pumped Ultralow-Threshold Raman Silicon Nanocavity Lasers (2018)

A Raman laser based on a high-$Q$ nanocavity in silicon has potential as a light source in photonic integrated circuits, but it is unclear how the significant enhancement of nonlinear optical effects by the cavity affects the lasing dynamics. Spectrally resolved time-domain measurements reveal that free carriers generated by two-photon absorption induce various dynamical effects during the initial lasing process, even at very low threshold power. Surprisingly, the Raman laser signal exhibits large oscillations at high excitation power. This insight will be useful for incorporating such Raman nanocavity lasers into device designs.
ICAM-1 and P-selectin expression in a model of NSAID-induced gastropathy (1998)

A growing body of experimental evidence suggests that neutrophilic polymorphonuclear leukocyte (PMN)-endothelial cell interactions play a critical role in the pathophysiology of nonsteroidal anti-inflammatory drug (NSAID)-induced gastropathy. The objective of this study was to directly determine whether the expression of endothelial cell adhesion molecules is enhanced in a model of NSAID-induced gastropathy. Gastropathy was induced in male Sprague-Dawley rats via oral administration of indomethacin (Indo, 20 mg/kg). Lesion scores, blood-to-lumen clearance of 51Cr-EDTA (mucosal permeability), and histological analysis (epithelial necrosis) were used as indexes of gastric mucosal injury. Gastric mucosal vascular expression of intercellular adhesion molecule 1 (ICAM-1) or P-selectin were determined at 1 and 3 h after Indo administration using the dual radiolabeled monoclonal antibody (MAb) technique. For some experiments, a blocking MAb directed at either ICAM-1 (1A29) or P-selectin (RMP-1) or their isotype-matched controls was injected intravenously 10 min before Indo administration. We found that P-selectin expression was significantly increased at 1 h but not 3 h after Indo administration, whereas ICAM-1 expression was significantly increased at both 1 and 3 h after Indo treatment. The blocking ICAM-1 and P-selectin MAbs both inhibited Indo-induced increases in lesion score, mucosal permeability, and epithelial cell necrosis. However, the Indo-induced gastropathy was not associated with significant PMN infiltration into the gastric mucosal interstitium, nor did Indo reduce gastric mucosal blood flow. We propose that NSAID-induced gastric mucosal injury may be related to the expression of P-selectin and ICAM-1; however, this mucosal injury does not appear to be dependent on the extravasation of inflammatory cells or mucosal ischemia.
Distinct Chemical and Physical Properties of Janus Nanosheets (2017)

Janus particles have recently garnered significant attention for their distinct properties compared to particles that are homogeneously functionalized. Moreover, high aspect ratio Janus particles that are rod-like or planar (i.e., nanosheets) are especially intriguing considering their interfacial properties as well as their ability to assemble into higher order and hybrid structures. To date, major challenges facing the exploration and utilization of 2D Janus particles are scalability of synthesis, characterization of tailored chemical functionalization, and ability to introduce a diverse set of functionalities. Herein, a facile method to access Janus 2D graphene oxide (GO) nanosheets by combining a Pickering-type emulsion and grafting-from polymerization via ATRP is reported. Janus GO nanosheets bearing PMMA on one face as well as the symmetrically functionalized analogue are prepared, and the chemical, thermal, structural, surface, and interfacial properties of these materials are characterized. Time-of-flight secondary ion mass spectrometry coupled with Langmuir-Blodgett films is shown to be an ideal route to conclusively establish asymmetric functionalization of 2D materials. This work not only provides a facile route for the preparation of Janus nanosheets but also demonstrates the direct visualization of polymer grown from the surface of GO.
The human factor: does the operator performing the embryo transfer significantly impact the cycle outcome? (2020)

NCT03561129.
Material platforms for integrated quantum photonics (2016)

On-chip integration of quantum optical systems could be a major factor enabling photonic quantum technologies. Unlike the case of electronics, where the essential device is a transistor and the dominant material is silicon, the toolbox of elementary devices required for both classical and quantum photonic integrated circuits is vast. Therefore, many material platforms are being examined to host the future quantum photonic computers and network nodes. We discuss the pros and cons of several platforms for realizing various elementary devices, compare the current degrees of integration achieved in each platform and review several composite platform approaches.
Abstract 4970: Mutational and functional analysis reveals ADAMTS18 metalloproteinase as a novel driver in melanoma (2011)

Abstract An important feature of cellular signaling and migration involves the proteolytic cleavage of extracellular matrix and/or pro-ligands involved in signal transduction. Proteins called proteases are responsible for this action and include the matrix-metalloproteinase family and the A Disintegrin and Metalloproteinases family to name a few. The A Disintegrin and Metalloproteinases with Thrombospondin domains (ADAMTS) have been suggested to function as tumor suppressors as several have been found to be epigenetically silenced in various cancers. Thus further analysis is warranted in determining if ADAMTS genes/proteins play a role in melanoma genesis. In the present study we performed a mutational analysis of 19 ADAMTS gene family members in human melanoma and identified a large fraction of melanomas to harbor somatic mutations. To evaluate the functional consequences of the most commonly mutated gene, ADAMTS18, six of its mutations were biologically examined. ADAMTS18 mutations had little effect on melanoma cell growth under standard conditions, but reduced cell dependence on growth factors. ADAMTS18 mutations also reduced adhesion to Laminin-I and increased migration in vitro and metastasis in vivo. Melanoma cells expressing mutant ADAMTS18 had reduced cell migration after shRNA-mediated knockdown of ADAMTS18, suggesting that ADAMTS18 mutations are growth-, migration- and metastasis- promoting in melanoma. These results demonstrate that the ADAMTS18 is a major target for mutational activation in melanoma and may be a useful diagnostic and/or therapeutic target. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4970. doi:10.1158/1538-7445.AM2011-4970
Surgical Technique Arthroscopic Posterior Glenoidplasty for Posterosuperior Glenoid Impingement in Throwing Athletes (2012)

Level IV, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.
Vaccination with type III secreted proteins leads to decreased shedding in calves after experimental infection with Escherichia coli O157. (2011)

Escherichia coli O157:H7 remains a threat to humans via cattle-derived fecal contamination of food and water. Preharvest intervention strategies represent a means of reducing the pathogen burden before harvest. In this study, the efficacy of a commercially produced type III secreted protein (TTSP) vaccine was evaluated with the use of a commingled experimental calf infection model (30 placebo-treated animals and 30 vaccinates). The calves were vaccinated on days 0, 21, and 42 and infected with 10(9) colony-forming units (CFU) of E. coli O157 by oral-gastric intubation on day 56. Fecal shedding was monitored daily for 14 d. Serologic assessment revealed a robust immune response to vaccination; the serum titers of antibodies against EspA, Tir, and total TTSPs were significantly higher in the vaccinates than in the placebo-treated animals on days 21, 42, 56, and 70. Significantly less (P = 0.011) of the challenge organism was shed by the vaccinates than by the placebo-treated animals on days 3 to 10. Peak shedding occurred in both groups on days 3 to 6; during this period the vaccinates showed a mean log reduction of 1.4 (P = 0.002) and a mitigated fraction of 51%. The number of animals shedding was significantly lower among the vaccinates compared with the placebo group on days 3 to 6 (P ≤ 0.05), with a mean prevented fraction of 21%. No differences in the duration of shedding were observed. Owing to the low challenge shedding in both groups on days 11 to 14 (mean CFU/g < 10; median = 0), no significant differences were observed. These data indicate that TTSP vaccination had protective effects through significant reductions in the number of animals shedding and the number of challenge organisms shed per animal and provides evidence that TTSP vaccination is an effective preharvest intervention strategy against E. coli O157.
Cavity optomechanics with sub-wavelength grating mirrors (2012)

We design, fabricate and study a novel platform for cavity optomechanics: a silicon nitride membrane patterned as a sub-wavelength diffraction grating. Using the grating as one mirror of a Fabry–Perot cavity, we realize an optical finesse of F = 2830 ± 60, corresponding to a grating reflectivity of R = 0.998. The finesse we achieve appears to be within a factor of two of the limit set by material absorption. We study the finesse as a function of wavelength and optical spot size in order to elucidate various optical loss mechanisms. We find that the cavity exhibits birefringence, and establish that it, too, is a source of optical loss. We then characterize the mechanical motion. We observe hundreds of normal modes, and find the fluctuating amplitude of one of them to be very well described by a Boltzmann distribution. By injecting a red-detuned cooling laser, we optically cool all of the modes that we observe. The lowest effective temperature we achieve is T _eff ≈ 1 K.
Supplementary Figure 1 from Progressive Chromatin Repression and Promoter Methylation of <i>CTNNA1</i> Associated with Advanced Myeloid Malignancies (2023)

Supplementary Figure 1 from Progressive Chromatin Repression and Promoter Methylation of &lt;i&gt;CTNNA1&lt;/i&gt; Associated with Advanced Myeloid Malignancies
CHARACTERIZATION APPROACH FOR COMPRESSION MOLDED DISCONTINUOUS FIBER THERMOPLASTIC COMPOSITES (2023)

Click on the link to access this conference paper (may not be free).
The Space of Possible Theories of Vagueness (2008)

Abstract This chapter presents the main existing theories of vagueness, as well as some possible theories which have not yet found advocates. Each theory is presented not necessarily as it was first presented in the literature, but rather as it looks from the point of view of the classical semantic picture. That is, the chapter examines whether, and if so how exactly, different theories of vagueness depart from that picture.
Metabolic Tumor Volume for Response Prediction in Advanced-Stage Hodgkin Lymphoma (2018)

<b>Rationale:</b> (<sup>18</sup>F)fluoro-2-deoxy-D-glucose (<sup>18</sup>F-FDG) positron emission tomography (PET)/computed tomography (CT) for staging Hodgkin lymphoma may allow for accurate and reliable assessment of the metabolic tumour volume (MTV) as baseline risk factor. Our aim was to analyse the prognostic impact of MTV measurements, obtained by different means in advanced-stage Hodgkin lymphoma patients treated within the German Hodgkin Study Group HD18 trial. <b>Methods:</b> Within the German Hodgkin Study Group trial HD18, 310 patients underwent <sup>18</sup>F-FDG PET/CT scanning for staging which was available to the central review panel for quantitative analysis. We calculated the MTV by four different thresholding methods and performed receiver operating characteristic (ROC) analysis to evaluate the potential for prediction of early response determined by PET after two cycles (PET-2) dose-escalated bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone (eBEACOPP). Logistic regression was used to evaluate its prognostic value concerning progression-free survival (PFS) and overall survival (OS). <b>Results:</b> All different MTV calculations used predicted PET-2 response to a moderate and comparable degree (area under the curve = 0.62-0.63, <i>P</i> = 0.01-0.06). With none of the measuring methods did the ROC curves point to any unique cut-off values, but indicated a wide range of possible cut-offs. However, none of the MTV measurements was prognostic for PFS (Hazard ratio 1.2-1.5, <i>P</i> = 0.15-0.52) or OS (Hazard ratio 1.0-1.5, <i>P</i> = 0.95 - 0.27). <b>Conclusion:</b> Baseline MTV as determined by different means, is a predictive factor for early response to eBEACOPP after two cycles. However, value as a prognostic factor after highly effective PET-2 adapted treatment strategy could not be observed.
Cytokine Gene Polymorphisms and Risks of Acute Rejection and Delayed Graft Function after Kidney Transplantation (2004)

Our results confirm that cytokine gene polymorphisms influence the outcome of kidney transplantation. Our data especially identify the TNF-alpha -308AA-genotype as a factor predisposing for AR episodes.
CCDC 1548670: Experimental Crystal Structure Determination (2017)

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.