gebhart/patrepeval huggingface dataset:
A model for HSDPA cell load and its applications (2005)

In this paper we discuss the application of HSDPA load control, which is required in order to preserve the quality of service (QoS) for the connected users. We present a novel HSDPA load model, which is an enhancement of the DSCH system level model that has been presented in J. Mueckenheim, et al (2004). We show by means of dynamic system level simulations how well the model fits to simulation results. Furthermore, we discuss the load control principles for HSDPA, which can be derived from the model. The meaning of HSDPA overload is described and it is shown that the model allows similar handling of the load control problem for the scheduled HSDPA system as for the regular CDMA system.
High-performance superconducting quantum processors via laser annealing of transmon qubits (2022)

Scaling the number of qubits while maintaining high-fidelity quantum gates remains a key challenge for quantum computing. Presently, superconducting quantum processors with >50 qubits are actively available. For these systems, fixed-frequency transmons are attractive because of their long coherence and noise immunity. However, scaling fixed-frequency architectures proves challenging because of precise relative frequency requirements. Here, we use laser annealing to selectively tune transmon qubits into desired frequency patterns. Statistics over hundreds of annealed qubits demonstrate an empirical tuning precision of 18.5 MHz, with no measurable impact on qubit coherence. We quantify gate error statistics on a tuned 65-qubit processor, with median two-qubit gate fidelity of 98.7%. Baseline tuning statistics yield a frequency-equivalent resistance precision of 4.7 MHz, sufficient for high-yield scaling beyond 10<sup>3</sup> qubit levels. Moving forward, we anticipate selective laser annealing to play a central role in scaling fixed-frequency architectures.
A Practical Guide to the Combinatorial Clock Auction (2017)

The combinatorial clock auction (CCA) is an important recent innovation in auction design that has been utilised for many spectrum auctions worldwide. While the theoretical foundations of the CCA are described in a growing literature, many of the practical implementation choices are neglected. In this article, we examine some of the most critical practical decisions for a regulator implementing the CCA. Topics include: implementation of reserve prices; endogenous band plans; supplementary round activity rules; competition policy; bidding languages; and allocation of the core burden. We illustrate our discussion with examples from recent spectrum auctions that used the CCA format.
Resonant Optics (2017)

The general class of devices called resonant optics is periodic or quasi-periodic and consists of metallic unit cells arranged in a 2D array on a dielectric substrate.We generally used 2D structures in our investigations, with multilayer structures used on occasion. Some embodiments used metallic ground planes and some did not, restricting or allowing their use in reflective or transmissive modes. In this chapter we describe three subclasses of device architectures: frequency-selective surfaces (FSSs), optical retarders, and reflectarrays.
TCP1 complex proteins interact with phosphorothioate oligonucleotides and can co-localize in oligonucleotide-induced nuclear bodies in mammalian cells (2014)

Phosphorothioate (PS) antisense oligonucleotides (ASOs) have been successfully developed as drugs to reduce the expression of disease-causing genes. PS-ASOs can be designed to induce degradation of complementary RNAs via the RNase H pathway and much is understood about that process. However, interactions of PS-ASOs with other cellular proteins are not well characterized. Here we report that in cells transfected with PS-ASOs, the chaperonin T-complex 1 (TCP1) proteins interact with PS-ASOs and enhance antisense activity. The TCP1-β subunit co-localizes with PS-ASOs in distinct nuclear structures, termed phosphorothioate bodies or PS-bodies. Upon Ras-related nuclear protein (RAN) depletion, cytoplasmic PS-body-like structures were observed and nuclear concentrations of PS-ASOs were reduced, suggesting that TCP1-β can interact with PS-ASOs in the cytoplasm and that the nuclear import of PS-ASOs is at least partially through the RAN-mediated pathway. Upon free uptake, PS-ASOs co-localize with TCP1 proteins in cytoplasmic foci related to endosomes/lysosomes. Together, our results indicate that the TCP1 complex binds oligonucleotides with TCP1-β subunit being a nuclear PS-body component and suggest that the TCP1 complex may facilitate PS-ASO uptake and/or release from the endocytosis pathway.
A REVERSIBLE THERMOSENSITIVE ADHESIVE FOR RETINAL IMPLANTS (2008)

ppNIPAM coated implants may provide retinal adhesion in vivo without measurable ocular toxicity in the short term. Covering a retinal tear, the ppNIPAM coated implants may prevent retinal detachment.
SEVOFLURANE SELECTIVELY DILATES CORONARY COLLATERAL VESSELS IN VIVO (1998)

ANESTHESIOLOGY is the highest-impact, peer-reviewed medical journal that publishes trusted evidence that transforms the practice of perioperative, critical care, and pain medicine along with clinical reviews, editorials, podcasts, infographics, and videos.
Diamond-silver apertures with plasmonic gratings (2012)

We have designed plasmonic gratings to improve collection and modify the far field profile of the enhanced single photon emission from a diamond-silver aperture. We implemented a fabrication procedure to realize such structures.
Pre-training of Hidden-Unit CRFs (2015)

Young-Bum Kim, Karl Stratos, Ruhi Sarikaya. Proceedings of the 53rd Annual Meeting of the Association for Computational Linguistics and the 7th International Joint Conference on Natural Language Processing (Volume 2: Short Papers). 2015.
Design of Pyridopyrazine-1,6-dione γ-Secretase Modulators that Align Potency, MDR Efflux Ratio, and Metabolic Stability (2015)

Herein we describe the design and synthesis of a series of pyridopyrazine-1,6-dione γ-secretase modulators (GSMs) for Alzheimer's disease (AD) that achieve good alignment of potency, metabolic stability, and low MDR efflux ratios, while also maintaining favorable physicochemical properties. Specifically, incorporation of fluorine enabled design of metabolically less liable lipophilic alkyl substituents to increase potency without compromising the sp(3)-character. The lead compound 21 (PF-06442609) displayed a favorable rodent pharmacokinetic profile, and robust reductions of brain Aβ42 and Aβ40 were observed in a guinea pig time-course experiment.
Integrated compact optical current sensors with high sensitivity (2016)

We demonstrate a Sagnac based fiber optic current sensor using only 10cm of terbium doped fiber with a high Verdet constant of 15.5 rad/Tm at a wavelength of 1300nm. Measurements of the fiber inside a solenoid show over 40dB of open loop dynamic range as well as a minimum detectable current of 0.1mA. In order to decrease size while increasing sensitivity even further, we consider integrated magneto-optic waveguides as the sensing element. Using silicon waveguides alongside magneto-optic material such as cerium doped yttrium iron garnet (Ce:YiG), we model the Verdet constant to be as high as 10,000 rad/Tm. This improvement by three orders of magnitude shows potential for magnetooptic waveguides to be used in ultra-high sensitivity optical magnetometers and current sensors. Finally, we propose a fully integrated optical current sensor using heterogeneous integration for silicon photonics.
Correction to Fragment-Based Identification of Influenza Endonuclease Inhibitors (2017)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to Fragment-Based Identification of Influenza Endonuclease InhibitorsCy V. Credille, Yao Chen, and Seth M. Cohen*Cite this: J. Med. Chem. 2017, 60, 23, 9912Publication Date (Web):December 1, 2017Publication History Published online1 December 2017Published inissue 14 December 2017https://doi.org/10.1021/acs.jmedchem.7b01683Copyright © 2017 American Chemical SocietyRIGHTS & PERMISSIONSACS AuthorChoiceArticle Views1350Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (343 KB) Get e-Alerts Get e-Alerts
Morphine inhibits human microglial cell production of, and migration towards, RANTES (2000)

The beta-chemokine RANTES has recently been implicated in the neuropathogenesis of the human immunodeficiency virus. Based upon previous studies of the effects of morphine on microglial cell production of cytokines and chemotaxis towards the activated complement component C5a, we tested the hypothesis that this opiate would alter the production of and migration towards RANTES by human microglia. Treatment of highly purified microglial cell cultures with morphine (10(-8)-10(-6) M) potently inhibited RANTES production by lipopolysaccharide- and interleukin-1beta-stimulated cells. Using a chemotaxis chamber to assess directed migration towards RANTES, treatment of microglial cells with morphine (10(-10)-10(-6) M) was found to suppress chemotaxis. The inhibitory effects of morphine on RANTES production and on chemotaxis were blocked by naloxone and beta-funaltrexamine, indicating that morphine mediated its suppressive effects via activation of microglial p-opioid receptors. Morphine's inhibitory effect on chemotaxis did not appear to be associated with an alteration in RANTES-induced [Ca2+]i mobilization. While the clinical significance of these in-vitro findings is unknown, they suggest that mu-opioid receptor agonists could alter certain neurodegenerative and inflammatory processes within the brain.
Synthesis of Fluoro‐, Monofluoromethyl‐, Difluoromethyl‐, and Trifluoromethyl‐Substituted Three‐Membered Rings (2020)

This Minireview describes recent advances toward the synthesis of fluoro-, monofluoromethyl-, difluoromethyl-, and trifluoromethyl-substituted three-membered rings such as cyclopropanes, aziridines, epoxides, episulfides, cyclopropenes, and 2 H-azirines. The main synthetic methodologies since 2016 for cyclopropanes and since 2010 for the other three-membered rings are reported.
Promoting Search Diversity in Ant Colony Optimization with Stubborn Ants (2012)

In ant colony optimization (ACO) methods, including Ant System and MAX-M IN Ant System, each ant stochastically generates its candidate solution, in a given iteration, based on the same pheromone T and heuristic η information as every other ant. Stubborn ants is an ACO variation in which if an ant generates a particular candidate solution in a given iteration, then the components of that solution will have a higher probability of being selected in the candidate solution generated by that ant in the next iteration. In previous work, we evaluated this variation with the M M AS Ant System model and the Traveling Salesman Problem (TSP), and found that it can both improve solution quality and reduce execution-time. In this paper, we evaluate stubborn ants with Ranked Ant System, and find that performance also improves in terms of solution quality and execution time.
A blocker-tolerant RF front end with harmonic-rejecting N-path filtering (2014)

A 0.2-1 GHz RF front end with a harmonic-rejecting N-path filter (HR-NPF) features tunable narrow band filtering as well as high attenuation at the 3rd and 5th order LO harmonics at the LNA output. The B1dB-CP is -2.4dBm at a 20MHz offset, and remains high at the 3rd and 5th LO harmonics thanks to the HR-NPF configuration. The reverse isolation of the LNA helps to keep the LO emission below -90dBm. The two-stage harmonic rejection approach offers >51dB harmonic rejection ratio at the 3rd and 5th LO harmonics without calibration. The front end consumes 26-32mA while occupying an area of 0.77mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .
Antioxidant and Cytotoxic Activity of a New Ferruginan A from Olea ferruginea: In Vitro and In Silico Studies (2022)

Studies of the ethyl acetate extract bark extract of <i>Olea ferruginea</i> led to the isolation of one new compound Ferruginan A (1) in addition to two known compounds, Ferruginan (2) and cycloolivil (3). Structures of the isolated compounds were confirmed by mass spectrometry (MS) and NMR spectral data. The ethyl acetate fraction and compounds (1-3) were evaluated against breast cancer cell line (MCF-7) and as antioxidants using the free radical scavenging assay. Results revealed that compound 2 exhibits significant antioxidant activity with an IC<sub>50</sub> value of 21.74 <i>μ</i>g/mL. In addition, the ethyl acetate fraction showed good cytotoxic activity (79.31% inhibition at 250 <i>μ</i>g/mL), whereas compounds 1-3 exerted mild cytotoxic activity (IC<sub>50</sub> = 8.03-12.01 <i>μ</i>g/mL) as compared to the standard (IC<sub>50</sub> = 4.41 <i>μ</i>g/mL) against MCF-7. Docking studies suggested that antioxidant activity is due to the chelation of compounds with copper present in the active site of tyrosinase. These results suggest that the extract exhibits considerable antioxidant activity, and the isolated compounds exert moderate anticancer activity.
The NEDD8 E3 ligase DCNL5 is phosphorylated by IKK alpha during Toll-like receptor activation (2018)

The activity of Cullin-RING ubiquitin E3 ligases (CRL) is regulated by NEDD8 modification. DCN-like proteins promote Cullin neddylation as scaffold-like E3s. One DCNL, DCNL5, is highly expressed in immune tissue. Here, we provide evidence that DCNL5 may be involved in innate immunity, as it is a direct substrate of the kinase IKKα during immune signalling. We find that upon activation of Toll-like receptors, DCNL5 gets rapidly and transiently phosphorylated on a specific N-terminal serine residue (S41). This phosphorylation event is specifically mediated by IKKα and not IKKβ. Our data for the first time provides evidence that DCNL proteins are post-translationally modified in an inducible manner. Our findings also provide the first example of a DCNL member as a kinase substrate in a signalling pathway, indicating that the activity of at least some DCNLs may be regulated.
OS0111 Behavior of water flow on rotating wafer in cleaning process (2016)

Behavior of water flow on rotating wafer were experimentally investigated. Liquid film thickness were measured by using a laser displacement meter. Shear force at the wafer surface by liquid film flow was estimated from the liquid film thickness. Removable diameter of the fine particles was estimated from the shear force. It was confirmed that the minimum removable diameter of fine particle become large around the area of hydraulic jump.
Conversion of grass pollen allergen-specific human IgE into a protective IgG1 antibody (2002)

More than 100 million individuals exhibit IgE-mediated allergic reactions against Phl p 2, a major allergen from timothy grass pollen. We isolated cDNA coding for three Phl p 2-specific human IgE antibodies from a combinatorial library, which was constructed from lymphocytes of a grass pollen-allergic patient. Recombinant Phl p 2-specific IgE antibody fragments (Fab) recognized a fragment comprising the 64 N-terminal amino acids of Phl p 2 and cross-reacted with group 2 allergens from seven grass species. cDNA coding for the variable regions of one of the IgE Fab were cloned into aplasmid vector expressing the constant region of human IgG(1) to obtain a complete, recombinant Phl p 2-specific human IgG(1). This antibody blocked the binding of grass pollen-allergic patients IgE (n=26; mean inhibition: 58%) to Phl p 2 and caused a 100-fold reduction of Phl p 2-induced basophil histamine release. The recombinant human Phl p 2-specific IgG(1) may be used for environmental allergen detection, for standardization of diagnostic as well as therapeutic grass pollen allergen preparations and for passive therapy of grass pollen allergy.
ChemInform Abstract: SYNTHESIS OF (3′,5′‐13C2)TYROSINE AND ITS USE IN THE SYNTHESIS OF SPECIFICALLY LABELED TYROSINE ANALOGS OF OXYTOCIN AND ARGININE VASOPRESSIN AND THEIR 2‐D‐TYROSINE DIASTEREOISOMERS (1979)

Abstract Ausgehend von dem 13 C‐markierten Aceton (I) erhält man das entsprechende markierte Tyrosin (II), das in verschiedene Peptide der Oxytocinund Arginin‐Vasopressin‐Reihe eingebaut wird.
Assessing climate change impacts, sea level rise and storm surge risk in port cities: A case study on Copenhagen (2009)

This study illustrates a methodology to assess economic impacts of climate change at city scale, focusing on sea level rise and storm surge. It is based on a statistical analysis of past storm surges in the studied city, matched to a geographical-information analysis of the population and asset exposure in the city, for various sea levels and storm surge characteristics. An assessment of direct losses in case of storm surge (i.e. of the damages to buildings and building content) can then be computed and the corresponding indirect losses – in the form of production and job losses, reconstruction duration, amongst other loses – deduced, allowing a risk analysis of the effectiveness of coastal flood protections, including risk changes due to climate change and sea level rise. This methodology is applied in the city of Copenhagen, capital of Denmark, which is potentially vulnerable to the effects of variability in sea level, as a low lying city....
Using biomarkers to stage disease progression in a lethal mousepox model treated with CMX001. (2008)

A single dose regimen of CMX001 is efficacious at treating mousepox. Disease progression and antiviral efficacy can be monitored using several biomarkers that could readily be used in the case of a human monkeypox or smallpox outbreak.
Deuteron NMR investigation of a photomechanical effect in a smectic-Aliquid crystal (2000)

Deuteron quadrupole-perturbed NMR is used to study the perturbation of orientational order in a smectic-A liquid crystal (octylcyanobiphenyl or 8CB) caused by photoinduced trans-to-cis isomerization of a photosensitive dopant (diheptylazobenzene or 7AB). The time and temperature dependences of the orientational order were independently studied for 8CB, 7AB, and their mixtures. Upon UV irradiation that causes trans-to-cis isomerization of 7AB, the orientational order parameter of the smectic-A phase is reduced. Relaxation in the dark exponentially restores the equilibrium value of the order parameter. The characteristic time for this process closely matches the lifetimes of the 7AB excited state. While in the 8CB smectic-A matrix, the cis-isomerized 7AB molecules retain a uniaxial orientational order with the director oriented along the normal to the smectic layers. The highly bent 7AB cis molecules act as a disorienting factor, decreasing the orientational order in the layers and causing a small increase in layer spacing. This disorder-induced increase in layer spacing is much smaller than the actual increase as observed by in situ x-ray experiments on UV-irradiated mixtures of 8CB:7AB. Concomitant with the experimental observation that only a fraction of 7AB molecules are converted to the cis state, this work provides indirect evidence for a nanophase segregation with the 7AB cis-isomers arranged within the interlayer space, thus significantly increasing the smectic layer spacing.
Origins of threshold voltage shifts in room-temperature deposited and annealed a-In–Ga–Zn–O thin-film transistors (2009)

Threshold voltage (Vth) stability was examined under constant current stress for a-In–Ga–Zn–O thin film transistors (TFTs) deposited at room temperature and annealed at 400 °C in dry or wet O2 atmospheres. All the TFTs exhibited positive Vth shifts (ΔVth) and the ΔVth value was reduced by the thermal annealing to &amp;lt;2 V for 50 h. TFT simulations revealed that the ΔVth for the annealed TFTs is explained by increase in deep charged defects. Large ΔVth over 10 V and deterioration in subthreshold voltage swing were observed in the unannealed TFTs, which are attributed to the increase in shallow trap states.
BBF RFC 38: RFC 38: Building Blocks - Standard Large DNA/Genome Construction (2009)

The physical assembly of standard parts is currently a non-standard process, which can either come from direct genome PCR with restriction enzyme sites incorporated into the PCR primers, or overlap assembly PCR. Furthermore, current Biobrick construction standards [RFC 10,11,12 etc.] rely heavily on restriction enzyme based methods, which can be sequence, cost and time restrictive. This is especially true of large DNA assembly, where 100% control of over DNA sequence may be mandatory, such as in whole genome assembly. We propose a novel standard, The Building Block Method, for both the construction of standard parts and their assembly This Building Block standard can be either A) an interchangeable or B) a non-interchangeable format, based on the desired use of the part.
Ribosome-catalyzed synthesis of protein/oligopeptides with unnatural backbone (2005)

Nonsense suppression method was used to probe the allowable modification of substrate (amino acid) backbone in the prokaryotic ribosomal system. Dihydrofolate reductase (DHFR) with an amber mutation was translated in the RF1-diminished prokaryotic cell free translation system in the presence of chemically-misacylated yeast tRNA(Phe)CUA. The prokaryotic ribosome showed a restricted tolerance to the backbone modification. Although natural-type alpha-amino acid was accepted as a good substrate for the ribosome, incorporation of beta-aminopropionic acid was not detected under our experimental conditions. Interestingly, we found that the homologous beta-hydroxyalkanoic acid with elongated methylene (backbone) chain-length can be a substrate for the ribosome, giving an important implication for the chemical mechanism of the ribosome-catalyzed peptide bond forming reaction.
S100A9 Interaction with TLR4 Promotes Tumor Growth (2012)

By breeding TRAMP mice with S100A9 knock-out (S100A9(-/-)) animals and scoring the appearance of palpable tumors we observed a delayed tumor growth in animals devoid of S100A9 expression. CD11b(+) S100A9 expressing cells were not observed in normal prostate tissue from control C57BL/6 mice but were readily detected in TRAMP prostate tumors. Also, S100A9 expression was observed in association with CD68(+) macrophages in biopsies from human prostate tumors. Delayed growth of TRAMP tumors was also observed in mice lacking the S100A9 ligand TLR4. In the EL-4 lymphoma model tumor growth inhibition was observed in S100A9(-/-) and TLR4(-/-), but not in RAGE(-/-) animals lacking an alternative S100A9 receptor. When expression of immune-regulating genes was analyzed using RT-PCR the only common change observed in mice lacking S100A9 and TLR4 was a down-regulation of TGFβ expression in splenic CD11b(+) cells. Lastly, treatment of mice with a small molecule (ABR-215050) that inhibits S100A9 binding to TLR4 inhibited EL4 tumor growth. Thus, S100A9 and TLR4 appear to be involved in promoting tumor growth in two different tumor models and pharmacological inhibition of S100A9-TLR4 interactions is a novel and promising target for anti-tumor therapies.