gebhart/patrepeval huggingface dataset:
Numerical Modeling of Nonlinear Deformation Behavior of Shallow Tunnel by Strain-Softening Analysis (2008)

In NATM tunnel constructions passing through unconsolidated soil and shallow depths, it is inevitable that ground displacement will occur around tunnels, which may significantly affect nearby structures. Experimental and numerical analysis approaches have been undertaken to understand deformation behaviors during tunneling. This paper consists of two phases. In the first phase, a numerical model that can account for reduction of shear stiffness and frictional strength parameters simultaneously was proposed to investigate the effects of key parameters on the deformation mechanisms on key parameters, e.g. nonlinear parameters, horizontal stress ratio, and shotcrete thickness. The second phase was performed to compare model test results with those of numerical modeling, for validating the proposed strain-softening analysis method.
High-frequency ZVS Ćuk converter for automotive LED driver applications using planar integrated magnetics (2017)

This paper presents a high-frequency zero voltage switching (ZVS) (Ćuk converter using planar integrated magnetics. The converter is intended for automotive LED driver applications. The converter switching frequency is above the AM frequency band to reduce radio frequency interference. The input inductor, the output inductor, and the transformer are realized on a single planar integrated magnetic structure, resulting in low input and output current ripples and reduced EMI. The planar integrated magnetics structure is optimized using 3D finite element method (FEM) tools. The transformer leakage inductance is minimized to eliminate the need for snubbers, while the magnetizing inductance is selected to achieve zero voltage switching (ZVS) over a wide range of operating points. Experimental 1.8 MHz-to-2.4 MHz Ćuk converter prototypes are constructed using Silicon MOSFETs or GaN transistors. The prototypes operate over an output voltage range from 3 V to 50 V, while supplying a constant 0.5 A output current to a string of 1-to-15 LEDs. Using Silicon MOSFETs, the prototype achieves a peak efficiency of 92.9%, while the GaN based prototype achieves a peak efficiency of 93.5%. Both prototypes maintain greater than 90% efficiency across a wide output voltage range.
Synthetic Weyl points in generalized parameter space and their topological properties (2016)

Weyl fermions1 do not appear in nature as elementary particles, but they are now found to exist as nodal points in the band structure of electronic and classical wave crystals. Novel phenomena such as Fermi arcs and chiral anomaly have fueled the interest of these topological points which are frequently perceived as monopoles in momentum space. Here, we demonstrate that generalized Weyl points can exist in a parameter space and we report the first observation of such nodal points in one-dimensional photonic crystals in the optical range. The reflection phase inside the band gap of a truncated photonic crystal exhibits vortexes in the parameter space where the Weyl points are defined and they share the same topological charges as the Weyl points. These vortexes guarantee the existence of interface states, the trajectory of which can be understood as "Fermi arcs" emerging from the Weyl nodes.
Synthetic biology projects in vitro (2006)

Advances in the in vitro synthesis and evolution of DNA, RNA, and polypeptides are accelerating the construction of biopolymers, pathways, and organisms with novel functions. Known functions are being integrated and debugged with the aim of synthesizing life-like systems. The goals are knowledge, tools, smart materials, and therapies.
Synthesis, Characterization, and Modeling of Nitrogen-Passivated Colloidal and Thin Film Silicon Nanocrystals (2006)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> We review our main experimental and theoretical results on the optical emission properties of Si-nanocrystals (Si-nc's) fabricated by colloidal and thin film deposition techniques, showing that the surface chemistry of the Si-nc's or the surrounding matrix play a crucial role in determining both the structural stability and the optoelectronic properties of Si-nc. Our results, guided by first-principles simulations indicate that nitrogen, oxygen, and carbon atoms bonded to the surface of nanometer silicon clusters play a crucial role in the emission mechanism of small Si quantum dots. The control and the understanding of the Si-nc surface structure and composition can provide alternative routes toward the fabrication of optically active complementary metal/oxide semiconductor devices. </para>
Glycocalyx regulation of vascular endothelial growth factor receptor 2 activity (2019)

We have previously shown that knockdown of endomucin (EMCN), an integral membrane glycocalyx glycoprotein, prevents VEGF-induced proliferation, migration, and tube formation <i>in vitro</i> and angiogenesis <i>in vivo</i>. In the endothelium, VEGF mediates most of its angiogenic effects through VEGF receptor 2 (VEGFR2). To understand the role of EMCN, we examined the effect of EMCN depletion on VEGFR2 endocytosis and activation. Results showed that although VEGF stimulation promoted VEGFR2 internalization in control endothelial cells (ECs), loss of EMCN prevented VEGFR2 endocytosis. Cell surface analysis revealed a decrease in VEGFR2 following VEGF stimulation in control but not siRNA directed against EMCN-transfected ECs. EMCN depletion resulted in heightened phosphorylation following VEGF stimulation with an increase in total VEGFR2 protein. These results indicate that EMCN modulates VEGFR2 endocytosis and activity and point to EMCN as a potential therapeutic target.-LeBlanc, M. E., Saez-Torres, K. L., Cano, I., Hu, Z., Saint-Geniez, M., Ng, Y.-S., D'Amore, P. A. Glycocalyx regulation of vascular endothelial growth factor receptor 2 activity.
Development of Novel Functionally Graded Al<sub>2</sub>O<sub>3</sub>-Lanthanum Hexaaluminate Ceramics for Thermal Barrier Coatings (2009)

Lanthanum hexaaluminate (LHA) has superior thermo-chemical stability at temperatures higher than 1000 °C and is a promising competitor to Y-ZrO2-based thermal barrier coatings (TBCs). The yet unresolved problem is control of microstructure of high LHA content ceramics and adjustment of porosity upon, to arrive at a material exhibiting low thermal conductivity at high temperature combined with structural reliability. Therefore, a functionally graded alumina/lanthanum hexaaluminate (FGLHA) with a gradient in composition was developed. The thermal diffusivity and thermal conductivity of FGLHA were compared with the one of the monolithic composite ceramics. The alumina-rich composites showed excellent mechanical properties whereas the LHA-rich composites presented lower thermal conductivity.
Murine Liver Myeloid Cell Isolation Protocol (2015)

In homeostasis, the liver is critical for the metabolism of nutrients including sugars, lipids, proteins and iron, for the clearance of toxins, and to induce immune tolerance to gut-derived antigens. These functions predispose the liver to infection by blood-borne pathogens, and to a variety of diseases ranging from toxin and medication-induced disorders (CCl4, acetaminophen) to metabolic disorders (steatohepatitis, alcoholic liver disease, biliary obstruction, cholestasis) or autoimmunity. Chronic liver injury often progresses to life threatening fibrosis and can end in liver cirrhosis and hepatocellular carcinoma (Pellicoro et al., 2014). The liver contains parenchymal cells or hepatocytes that make up the majority of hepatic cells. It also contains non-parenchymal structural cells such as sinusoidal endothelial cells and a large number of non-parenchymal innate immune cells, mainly monocytes, neutrophils, macrophages, DCs, NK and NKT cells that can trigger an adaptive immune response in the case of infections or other pathogenic insults (Jenne and Kubes, 2013). How this immune response is regulated determines the extent of acute and chronic liver injury (Stijlemans et al., 2014). In this context, liver macrophages have been demonstrated to play central but divergent (from initiating to resolving) functions in liver injury (Sica et al., 2014). It has become clear in the last years that hepatic macrophages consist of two classes, tissue-resident macrophages, the Kupffer cells (KCs) originating from yolk sac/fetal liver progenitors and tissue-infiltrating macrophages originating from bone marrow-derived Ly6CHi monocytes (Jinhoux and Jung, 2014; Tacke and Zimmerman, 2014). Distinguishing the activities of KCs from those of monocyte-derived macrophages during liver injury or repair is currently a frontline research topic in the macrophage field. Indeed, considering that clinical management of liver failure remains problematic, a better understanding of the immune mechanisms regulating liver injury is expected to allow the development of new therapeutic modalities. Here, we describe an isolation technique for liver non-parenchymal polymorphonuclear (PMN) and mononuclear myeloid cells permitting their molecular and functional characterization.
Supplementary Figures 1 - 5 from Prooncogenic Factors miR-23b and miR-27b Are Regulated by Her2/<i>Neu</i>, EGF, and TNF-α in Breast Cancer (2023)

&lt;p&gt;PDF file - 131K, Supplementary Figure S1. Luciferase reporter assay and expression levels of miR-23b and miR-27b and their putative targets. Supplementary Figure S2. Antisense miR-23b and miR-27b inhibited cell invasion. Supplementary Figure S3. The expression of miR-23b/27b and Nischarin in knockdown cells. Supplementary Figure S4. MEK1 inhibitor (U0126) did not affect expression of miR-23b/27b in SKBR3 cells. Supplementary Figure S5. EGF and TNF enhanced miR-23b and miR-27b expression in MDA-MB-231 cells.&lt;/p&gt;
Microelectromechanical (MEMS)-Based Data Storage (2003)

Abstract : This project developed and demonstrated design and fabrication technologies required to enable mass production of MEMS micromovers and electrostatic motors required to actuate these structures, including suspension systems of unprecedented high aspect ration by Hewlett Packard. Single and multiple level electrical interconnect fabrication techniques were developed and refined by Cornell University. A technique to fabricate large arrays of field emission tips was developed by U.C. Davis.
Applying attention investment to end-user programming (2003)

Attention investment is a model to help the designers of end-user programmable systems understand the cognitive drivers for users deciding how to interact with their products. We present the attention investment model through examples drawn from an actual design project. This project is developing new functionality within Forms/3, a research test-bed for a concept called "end-user software engineering". As the examples show, our experience is that attention investment provides a useful design tool for the development of end-user programming features.
A Perspective on the Development of Intelligent Robots for Manipulation in Space (2005)

NASA has had a long involvement with robot systems for the exploration of space. From space probes to soil samplers to the Shuttle Remote Manipulator, robotic devices have proven themselves useful in many different tasks. Robotic devices are characterized by the ability to be reprogrammed, to change their operation through commands generated locally or remotely. The future exploration and exploitation of space will the current generation of robots as well as future intelligent robots. Intelligent robots in space include a wide variety of machines and devices which have a much higher range of capabilities than those used today. These robots will have the capability not only to be reprogrammed, but to reprogram themselves. The robots have the means to plan and schedule tasks independently, if necessary, and to execute these tasks. Intelligent robotic systems have their uses in all phases of the space effort. This includes intelligent probes used to gather information, intelligent exploration vehicles for planetary surfaces, and intelligent manipulators for operations in-orbit and beyond.
Specificity of Coupling of Muscarinic Receptor Isoforms to a Novel Chick Inward-rectifying Acetylcholine-sensitive K+ Channel (1996)

The G-protein-gated inward-rectifying K+ channel GIRK1 has been demonstrated in heart and brain. These tissues also both express the M2, M3, and M4, muscarinic acetylcholine receptors (mAChR) (Gadbut, A.P., and Galper, J.B. (1994),J. Biol. Chem. 269,25823-25829). Only the M2 mAChR has been demonstrated to couple to GIRK1 (Kubo, Y., Reuveny, E., Slesinger, P. A., Jan, Y. N., and Jan, L. Y. (1993) Nature 264, 802-806). In this study we determined the specificity of coupling of the M3 and M4 mAChR to a new GIRK1 cloned from a chick brain cDNA library. This clone codes for a 492-amino acid protein that is 93% identical to rat GIRK1 and is expressed in brain, atrium, and ventricle, but not skeletal muscle. In Xenopus laetis oocytes co-expression of GIRK1 with either the chick M2 or M4 mAChR gave carbamylcholine (10 microm)-stimulated K+ currents of 308 +/-26 nA and 298 +/-29 nA, respectively, which were both Ba2+- and pertussis toxin-sensitive. Activation of the M3 receptor produced 2382 +/-478 nA of current which was insensitive to Ba2+ and pertussis toxin, but was 85% inhabitable by the Cl channel blocker 5-nitro-2-(3-phenylpropylamino)benzoic acid (10-20 microm) consistent with coupling to an endogenous Ca2+-activated Cl- channel via a phosphatidylinositol-dependent mechanism. Co-expression of the cardiac inward rectifier CIR with chick M2 or M4 mAChR and GIRK1 increased currents more than 10-fold, but had no effect on specificity of coupling. These data demonstrate a new function for the M4 mAChR and a high degree of specificity for coupling of each receptor subtype to GIRK1.
Co-active Learning to Adapt Humanoid Movement for Manipulation (2016)

In this paper we address the problem of robot movement adaptation under various environmental constraints interactively. Motion primitives are generally adopted to generate target motion from demonstrations. However, their generalization capability is weak while facing novel environments. Additionally, traditional motion generation methods do not consider the versatile constraints from various users, tasks, and environments. In this work, we propose a co-active learning framework for learning to adapt robot end-effector's movement for manipulation tasks. It is designed to adapt the original imitation trajectories, which are learned from demonstrations, to novel situations with various constraints. The framework also considers user's feedback towards the adapted trajectories, and it learns to adapt movement through human-in-the-loop interactions. The implemented system generalizes trained motion primitives to various situations with different constraints considering user preferences. Experiments on a humanoid platform validate the effectiveness of our approach.
Unusual chromic and doping behavior of ether substituted polythiophenes (2004)

Poly[3-(oligoethylene oxide)-4-methylthiophene] is doped by HCl in aqueous solution in the absence of oxygen and undergoes dramatic solvatochromism in water-ethanol mixtures.
O-linked mucin-type glycosylation regulates the transcriptional programme downstream of EGFR in breast cancer (2019)

ABSTRACT Aberrant mucin type O-linked glycosylation is a common occurrence in cancer. This type of O-linked glycosylation is not limited to mucins but can occur on many cell surface glycoproteins where only a small number of sites may be present. Upon EGF ligation, EGFR induces a signaling cascade but can also translocate to the nucleus where it can directly regulate gene transcription. Here we show that upon EGF binding, human breast cancer cells carrying different O-linked glycans respond by transcribing different gene expression signatures. This is not a result of changes in signal transduction but due to the differential nuclear translocation of EGFR in the two glyco-phenotypes. This is regulated by the formation of an EGFR/galectin-3/MUC1/β-catenin complex at the cell surface that is present in cells carrying short core-1-based O-glycans characteristic of tumour cells but absent in core-2-carrying cells.
Monolithic integration of Magneto-Optical Plasmonic Waveguides with GaAs/Al-GaAs Waveguides on GaAs Substrate and with Si Nanowire Waveguides on Si sub-strate for Integrated Non-reciprocal Optical Devices (2014)

2014 International Conference on Solid State Devices and Materials,Monolithic integration of Magneto-Optical Plasmonic Waveguides with GaAs/Al-GaAs Waveguides on GaAs Substrate and with Si Nanowire Waveguides on Si sub-strate for Integrated Non-reciprocal Optical Devices
Supplementary Methods, Figure Legends 1-6 from An Oncogenic Role for <i>ETV1</i> in Melanoma (2023)

Supplementary Methods, Figure Legends 1-6 from An Oncogenic Role for &lt;i&gt;ETV1&lt;/i&gt; in Melanoma
Privacy preservation of aggregates in hidden databases (2009)

Many websites provide form-like interfaces which allow users to execute search queries on the underlying hidden databases. In this paper, we explain the importance of protecting sensitive aggregate information of hidden databases from being disclosed through individual tuples returned by the search queries. This stands in contrast to the traditional privacy problem where individual tuples must be protected while ensuring access to aggregating information. We propose techniques to thwart bots from sampling the hidden database to infer aggregate information. We present theoretical analysis and extensive experiments to illustrate the effectiveness of our approach.
Identification of mcl-1 as a BCR/ABL-dependent target in chronic myeloid leukemia (CML): evidence for cooperative antileukemic effects of imatinib and mcl-1 antisense oligonucleotides (2004)

Antiapoptotic members of the bcl-2 family have recently been implicated in the pathogenesis of chronic myeloid leukemia (CML), a hematopoietic neoplasm associated with the BCR/ABL oncogene. We have examined expression of MCL-1 in primary CML cells and BCR/ABL-transformed cell lines. Independent of the phase of disease, isolated primary CML cells expressed myeloid cell leukemia-1 (mcl-1) mRNA and the MCL-1 protein in a constitutive manner. The BCR/ABL inhibitor imatinib (=STI571) decreased the expression of MCL-1 in these cells. Correspondingly, BCR/ABL enhanced mcl-1 promoter activity, mcl-1 mRNA expression, and the MCL-1 protein in Ba/F3 cells. BCR/ABL-dependent expression of MCL-1 in Ba/F3 cells was counteracted by the mitogen-activated protein-kinase/extracellular signal-regulated kinase (MEK) inhibitor, PD98059, but not by the phosphoinositide 3-kinase inhibitor, LY294002. Identical results were obtained for constitutive expression of MCL-1 in primary CML cells and the CML-derived cell lines K562 and KU812. To investigate the role of MCL-1 as a survival-related target in CML cells, mcl-1 siRNA and mcl-1 antisense oligonucleotides (ASOs) were applied. The resulting down-regulation of MCL-1 was found to be associated with a substantial decrease in viability of K562 cells. Moreover, the mcl-1 ASO was found to synergize with imatinib in producing growth inhibition in these cells. Together, our data identify MCL-1 as a BCR/ABL-dependent survival factor and interesting target in CML.
DCLK1 is a broadly dysregulated target against epithelial-mesenchymal transition, focal adhesion, and stemness in clear cell renal carcinoma (2014)

Renal clear cell carcinoma (RCC) is the most common type of kidney cancer and the 8th most common cancer overall in the US. RCC survival rates drop precipitously with regional and distant spread and recent studies have demonstrated that RCC presents an epithelial-mesenchymal transition (EMT) phenotype linked to increased recurrence and decreased survival. EMT is a key characteristic of tumor stem cells (TSCs) along with chemo-resistance and radio-resistance, which are also phenotypic of RCC. Targeting these factors is key to increasing the survival of RCC patients. Doublecortin-like kinase 1 (DCLK1) marks TSCs in pancreatic and colorectal cancer and regulates EMT and stemness. Analysis of the Cancer Genome Atlas' RCC dataset revealed that DCLK1 is overexpressed and dysregulated on the mRNA and epigenetic level in more than 93% of RCC tumors relative to adjacent normal tissue. Immunohistochemistry using α-DCLK1 antibody confirmed overexpression and demonstrated a major increase in immunoreactivity in stage II-III tumors compared to normal kidney and stage I tumors. Small-interfering RNA (siRNA) mediated knockdown of DCLK1 resulted in decreased expression of EMT and pluripotency factors and significantly reduced invasion, migration, focal adhesion, drug-resistance, and clonogenic capacity. These findings suggest that DCLK1 is a novel, overexpressed factor in RCC progression that may be targeted to suppress EMT, metastasis, and stemness in early-stage and advanced RCC to increase patient survival. Moreover, the possibility that DCLK1 may mark a population of tumor stem-like cells in RCC should be further investigated in light of these findings.
Effects of Grain Refinement and Predeformation Impact by Severe Plastic Deformation on Creep in P92 Martensitic Steel (2019)

Creep testing is conducted on an advanced martensitic‐ferritic creep‐resistant P92 steel (ASME Grade 92) to evaluate the effects of grain refinement and the predeformation impact after processing by severe plastic deformation (SPD), namely, by high‐pressure torsion and high‐pressure sliding. Constant‐load tensile creep tests are carried out in an argon atmosphere at 600 °C and under an applied stress ranging from 50 to 200 MPa. The results show that under the same creep loading conditions, the ultrafine‐grained (UFG) microstructure states after SPD processing exhibit higher minimum creep rate m and creep fracture plasticity , but significantly shorter creep lives in comparison with the coarse‐grained (as‐received) state of the steel. These distinct differences between the coarse‐grained and UFG states are explained by the different deformation mechanisms that operate; creep behavior in a coarse‐grained state is controlled by the intragranular climb of dislocations, while creep in UFG states can be interpreted as the synergistic action of the dynamic recovery of free dislocations at high‐angle grain boundaries and grain boundary‐mediated deformation processes.
Ship‘s PTO / PTI Torque Field Oriented Control scheme, with optimization strategy, for EEDI index improvement (2018)

The following work introduces the implementation of a Torque Field Oriented Control scheme with a selective optimization strategy, in driven Permanent Magnet Synchronous Machine (PMSM), within a marine diesel engine propulsion system. The optimization strategy forces the electric drive to operate in power take-off or take-in modes, in order to ensure a minimum emissions operating point (MEOP) for the diesel engine prime mover. Simulation results were obtained for different operation conditions for the diesel engine, based on the Energy Efficiency Design Index (EEDI).
Size and spatial distributions of precipitates in the Ostwald ripening in some alloys (1992)

The radii and the three‐dimensional coordinates of the centers of spherical precipitates were determined in Al‐Li and Cu‐Co alloys by the stereographic method under an electron microscope. The distribution of the radii and that of the interparticle distances to the first nearest neighbors were obtained on isothermal aging. The size distributions normalized by the average radius were consistent with any of the existing theoretical predictions without consideration of elastic interaction between precipitates. The spatial distribution can be accounted for by the assumption of an isotropic random distribution of particles of finite size. In the analysis the effect of the volume fraction of precipitates plays an essential role.