gebhart/patrepeval huggingface dataset:
System and method for evaluating wind flow fields using remote sensing devices (2023)

The present invention provides a system and method for obtaining data to determine one or more characteristics of a wind field using a first remote sensing device and a second remote sensing device. Coordinated data is collected from the first and second remote sensing devices and analyzed to determine the one or more characteristics of the wind field. The first remote sensing device is positioned to have a portion of the wind field within a first scanning sector of the first remote sensing device. The second remote sensing device is positioned to have the portion of the wind field disposed within a second scanning sector of the second remote sensing device.
Temperaturabhängigkeit der Phosphor-HFS bei Iminophosphoran- Radikalen / Temperature Dependence of ESR-Phosphorus Coupling Constants of Iminophosphorane Radicals (1975)

ESR-spectra of iminophosphorane radicals exhibit a strong temperature dependent coupling constant of the phosphorus nucleus. This splitting is described by a superposition of π-σ- and hyperconjugative interactions with the free electron. Because of hindered internal rotation of the iminophosphorane group the hyperconjugation term becomes temperature dependent. Differences in the phosphorus data of ortho- and para-iminophosphorane radicals respectively may be explained by a change of the potential barriers hindering the internal rotation
Collaborative model of care between Orthopaedics and allied healthcare professionals trial (CONNACT) – a feasibility study in patients with knee osteoarthritis using a mixed method approach (2020)

Retrospectively registered on 18 January 2019 at http://clinicaltrial.gov ID: NCT03809975 .
Local electrical stimulation of single adherent cells using three-dimensional electrode arrays with small interelectrode distances (2009)

In this paper, we describe the localized and selective electrical stimulation of single cells using a three-dimensional electrode array. The chip consisted of 84 nail-like electrodes with a stimulation surface of 0.8 um and interelectrode distances as small as 3 um. N2A cells were used to compare bipolar stimulation between one electrode in- and one outside the cell on the one hand, and two electrodes in the same cell on the other hand. Selective and localized stimulation of primary embryonic cardiomyocytes showed the possibility to use this chip with excitable cells. The response of the cells to applied electrical fields was monitored using calcium imaging whereas assessment of electroporation was determined following influx of propidium iodide. Arrays of these three-dimensional electrodes could eventually be used as a tool to selectively electroporate the membrane of single cells for genetic manipulation or to obtain electrical access to the inner compartment of the cell.
Surgical outcomes in the treatment of patients with tetralogy of Fallot and absent pulmonary valve☆ (2007)

In contrast to children and adults with TOF/APV, neonates and small infants presenting with respiratory symptoms require prolonged ventilation and additional reinterventions for airway compression. Our current surgical approach which includes reduction and suspension of pulmonary arteries, reconstruction of a competent RVOT, and aggressive postoperative ventilatory management to relieve airway obstruction offers satisfactory outcomes.
Rare Complication of Endourologic Procedure: Urethral Manipulation Syndrome (1988)

Fibrosis of the corpus spongiosum caused by urethral or transurethral manipulations and the resulting ventral deviations of the erect penis were described as urethral manipulation syndrome (UMS) in 1984. Because the transurethral route is used for some endourologic manipulations of the upper urinary tract, complications that can arise from these procedures are the concern of the urologist. All transurethral manipulations cause some degree of urethral inflammation, which is usually transient. When this inflammation does not subside, it may cause fibrosis of the corpus spongiosum, leading to ventral bending of the penis during erections. Surgery is indicated when the curvature causes sexual dysfunction or is accompanied by severe urethral strictures. Four demonstrative cases are presented.
Analysis and design of AlGaInP single-quantum-well LED (1999)

Calculations are done and compared for two AlGaInP single- quantum-well (SQW) LED structures: step separate- confinement-heterostructure (SCH) SQW structure and graded- index (GRIN) SCH-SQW structure. It is found that the latter has better performance in terms of spontaneous lifetime and injection efficiency. This is attributed to greater barrier height to electron leakage and substantial overlap between wavefunctions of different quantum numbers in the GRIN-SCH- SQW structure. Results also show that the GRIN layer thickness has no influence on the QW energy levels. spontaneous lifetime and injection efficiency in a GRIN-SCH- SQW.
Differentially Expressed Proteins in the Pancreas of Diet-induced Diabetic Mice (2005)

The pancreas is a heterogeneous organ mixed with both exocrine and endocrine cells. The pancreas is involved in metabolic activities with the endocrine cells participating in the regulation of blood glucose, while the exocrine portion provides a compatible environment for the pancreatic islets and is responsible for secretion of digestive enzymes. The purpose of this study was to identify pancreatic proteins that are differentially expressed in normal mice and those with diet-induced type 2 diabetes (T2DM). In this study, C57BL/6J male mice fed a high fat diet became obese and developed T2DM. The pancreatic protein profiles were compared between control and diabetic mice using two-dimensional gel electrophoresis. Differentially expressed protein "spots" were identified by mass spectrometry. REG1 and REG2 proteins, which may be involved in the proliferation of pancreatic beta cells, were up-regulated very early in the progression of obese mice to T2DM. Glutathione peroxidase, which functions in the clearance of reactive oxidative species, was found to be down-regulated in the diabetic mice at later stages. The RNA levels encoding REG2 and glutathione peroxidase were compared by Northern blot analysis and were consistent to the changes in protein levels between diabetic and control mice. The up-regulation of REG1 and REG2 suggests the effort of the pancreas in trying to ameliorate the hyperglycemic condition by stimulating the proliferation of pancreatic beta cells and enhancing the subsequent insulin secretion. The down-regulation of glutathione peroxidase in pancreas could contribute to the progressive deterioration of beta cell function due to the hyperglycemia-induced oxidative stress.
Effect of surface and intracellular pH on hepatocellular fatty acid uptake (1996)

Fatty acids enter hepatocytes, at least in part, by a carrier-mediated uptake mechanism. The importance of driving forces for fatty acid uptake is still controversial. To evaluate possible driving mechanisms for fatty acid transport across plasma membranes, we examined the role of transmembrane proton gradients on fatty acid influx in primary cultured rat hepatocytes. After hepatocytes were loaded with SNARF-1 acetoxymethyl ester, changes in intracellular pH (pHi) under different experimental conditions were measured and recorded by confocal laser scanning microscopy. Fatty acid transport was increased by 45% during cellular alkalosis, achieved by adding 20 mM NH4Cl to the medium, and a concomitant paracellular acidification was observed. Fatty acid uptake was decreased by 30% during cellular acidosis after withdrawal of NH4Cl from the medium. Cellular acidosis activates the Na+/H+ antiporter to export excessive protons to the outer cell surface. Inhibition of Na+/H+ antiporter activity by amiloride diminishes pHi recovery and thereby accumulation of protons at the outer surface of the plasma membrane. Under these conditions, fatty acid uptake was further inhibited by 57% of control conditions. This suggests stimulation of fatty acid influx by an inwardly directed proton gradient. The accelerating effect of protons at the outer surface of the plasma membrane was confirmed by studies in which pH of the medium was varied at constant pHi. Significantly higher fatty acid influx rates were observed at low buffer pH. Recorded differences in fatty acid uptake appeared to be independent of changes in membrane potential, because BaCl2 did not influence initial uptake velocity during cellular alkalosis and paracellular acidosis. Moreover, addition of oleate-albumin mixtures to the NH4Cl incubation buffer did not change the observed intracellular alkalinization. In contrast, after cells were acid loaded, addition of oleate-albumin solutions to the recovery buffer increased pHi recovery rates from 0.21 +/- 0.02 to 0.36 +/- 0.05 pH units/min (P < 0.05), indicating that fatty acids further stimulate Na+/H+ antiporter activity during pHi recovery from an acid load. It is concluded that carrier-mediated uptake of fatty acids in hepatocytes follows an inwardly directed transmembrane proton gradient and is stimulated by the presence of H+ at the outer surface of the plasma membrane.
CMOS Integration of Capacitive, Optical, and Electrical Interconnects (2007)

We present a 90 nm test chip integrating proximity communication, optics using external lasers and photodiodes, and CML electronics on a single CMOS chip which can route data at multi-Gb/s rates through any combination of its three interconnect interfaces. A robust and flexible unclocked datapath allows independent timing and margin characterization of each path.
Volatile Fatty Acid-Sensing System Involving Coenzyme-A Transferase (2006)

On-site monitoring of volatile fatty acids (VFAs), such as propionate, is industrially and medically important. The present study developed a VFA biosensing system comprised of two recombinant enzymes, propionate coenzyme A (CoA) transferase (PCT) from Clostridium propionicum and acyl-CoA oxidase from Arabidopsis thaliana. This system produced hydrogen peroxide in the presence of acetyl-CoA, oxygen, and VFA substrates, which could be quantified by colorimetric methods using peroxidase and dye reagents (e.g., p-aminobenzoic acid plus 4-aminoantipyrine or Amplex Red). The use of PCT and acetyl-CoA, rather than acyl-CoA synthetases (ACS) and CoA-SH, obviated a background reaction of dye reagents with CoA-SH and enabled very sensitive detection of VFAs (down to 1 microM propionate, more than 100-fold more sensitive compared to previously developed ACS biosensors). We demonstrated its utility by measuring propionate concentrations in serum and fermentation samples. Results suggest that our biosensing system is applicable to the detection of propionate in medical and fermentation samples.
13C NMR Studies on Zr(ansa-Fluorenyl) Complexes. Molecules with Flexible Bonding Modes (2000)

13C NMR spectra for the zirconium−fluorenyl complexes ZrCl2(η5-C5H4CR2- η5-C13H8), R = Ph, Me, 3 and 4, respectively, have been recorded. Analyses of the chemical shift data suggest that the hapticity is strongly distorted from that indicated above and that η3 and η1, respectively, would be better, but still not exact descriptions. Long-range (multiple bond) 13C,1H correlations are shown to be important, in that without a complete 13C assignment one can easily be mislead.
Alcohol-Metabolizing Genes and Alcohol Phenotypes in an Israeli Household Sample (2013)

This study adds support for the relationship of ADH1B and ADH1C and alcohol phenotypes in non-Asians. Further, these findings help clarify the mixed results from previous studies by showing that ADH1B and ADH1C jointly effect AUDs, but not consumption. Studies of the association between alcohol phenotypes and either ADH1B or ADH1C alone may employ an oversimplified model, masking relevant information.
Search for the Standard Model Higgs Boson in the Diphoton Decay Channel with4.9  fb−1ofppCollision Data ats=7  TeVwith ATLAS (2012)

A search for the standard model Higgs boson is performed in the diphoton decay channel. The data used correspond to an integrated luminosity of 4.9 fb(-1) collected with the ATLAS detector at the Large Hadron Collider in proton-proton collisions at a center-of-mass energy of √s=7 TeV. In the diphoton mass range 110-150 GeV, the largest excess with respect to the background-only hypothesis is observed at 126.5 GeV, with a local significance of 2.8 standard deviations. Taking the look-elsewhere effect into account in the range 110-150 GeV, this significance becomes 1.5 standard deviations. The standard model Higgs boson is excluded at 95% confidence level in the mass ranges of 113-115 GeV and 134.5-136 GeV.
Performance and Deployment Status of MUSCAT: a 1500-Pixel LEKID-Based mm-Wave Camera for the Large Millimeter Telescope (2020)

The Mexico-UK Sub-Millimetre Camera for AsTronomy (MUSCAT) is a 1.1-mm band receiver consisting of 1,500 single-colour lumped-element kinetic inductance detectors and is scheduled for deployment to the Large Millimeter Telescope (LMT) after the ongoing COVID-19 pandemic. MUSCAT is designed to utilise the full field of view of the LMT's upgraded 50-m primary mirror (approximately 4'). Here we will present the as-measured performance of MUSCAT from the final lab-verification testing prior to shipping to the LMT. We will also explain the overall design of MUSCAT including the novel technologies utilised-such as continuous cooling using sorption coolers and a miniature dilutor, and horn-coupled LEKIDs-for which MUSCAT will provide a first on-sky demonstration.
Serotonin receptor expression in hippocampus and temporal cortex of temporal lobe epilepsy patients by postictal generalized electroencephalographic suppression duration (2022)

Higher hippocampal 5HT2A receptor protein and potassium channel transcripts may reflect underlying mechanisms contributing to or resulting from prolonged PGES. Future studies with larger cohorts should assess functional analyses and additional brain regions to elucidate mechanisms underlying PGES and SUDEP risk.
Massively multiplexed microbial identification using resequencing DNA microarrays for outbreak investigation (2011)

Multiplexed microbial diagnostic assays are a promising method for detection and identification of pathogens causing syndromes characterized by nonspecific symptoms in which traditional differential diagnosis is difficult. Also such assays can play an important role in outbreak investigations and environmental screening for intentional or accidental release of biothreat agents, which requires simultaneous testing for hundreds of potential pathogens. The resequencing pathogen microarray (RPM) is an emerging technological platform, relying on a combination of massively multiplex PCR and high-density DNA microarrays for rapid detection and high-resolution identification of hundreds of infectious agents simultaneously. The RPM diagnostic system was deployed in Sierra Leone, West Africa in collaboration with Njala University and Mercy Hospital Research Laboratory located in Bo. We used the RPM-Flu microarray designed for broad-range detection of human respiratory pathogens, to investigate a suspected outbreak of avian influenza in a number of poultry farms in which significant mortality of chickens was observed. The microarray results were additionally confirmed by influenza specific real-time PCR. The results of the study excluded the possibility that the outbreak was caused by influenza, but implicated Klebsiella pneumoniae as a possible pathogen. The outcome of this feasibility study confirms that application of broad-spectrum detection platforms for outbreak investigation in low-resource locations is possible and allows for rapid discovery of the responsible agents, even in cases when different agents are suspected. This strategy enables quick and cost effective detection of low probability events such as outbreak of a rare disease or intentional release of a biothreat agent.
Wave Packet Transmission in a ZnO Nanorod under the Influence of Repulsive/Attractive Scattering Center (2004)

We study electron wave packet propagation and scattering in ZnO nanorods. By solving the time-dependent three-dimensional Schrödinger equation, we were able to describe propagation and dynamics of the scattering process of the wave packet by ionized impurities. Scattering behavior of the wave packet by an attractive/repulsive scattering center is clearly demonstrated.
Improvement of wind turbine blade aerodaynamics (2010)

Recently there has been an increase in the demand for the utilization of clean renewable energy sources. This is a direct result of a rise in oil prices and an increased awareness of human induced climate change. Wind energy has been shown to be one of the most promising sources of renewable energy. With current technology, the low cost of wind energy is competitive with more conventional sources of energy such as coal. This paper explores the possibility of increasing the number of profitable sites by optimizing wind turbine blade design for low wind speed areas.
Multicenter Clinical Trials Using 18F-FDG PET to Measure Early Response to Oncologic Therapy: Effects of Injection-to-Acquisition Time Variability on Required Sample Size (2015)

Uptake-time deviations from standardized protocols occur frequently, potentially decreasing the performance of (18)F-FDG PET response biomarkers. Correcting SUV for uptake time improves sensitivity, but algorithm refinement is needed. Stricter uptake-time control and effective correction algorithms could improve power and decrease costs for clinical trials using (18)F-FDG PET endpoints.
Optical trapping forces on biological cells on a waveguide surface (2011)

A three dimensional finite element method is used to model the forces acting on red blood cells trapped on an optical waveguide surface. The parameters are chosen to correspond to strip waveguides made of tantalum pentoxide (Ta<sub>2</sub>O<sub>5</sub>). A wavelength of 1070 nm is used and the cells are taken to be spherical. Gradient and scattering forces experienced by the cells are studied and found to be highly dependent on the refractive index of the cells. Gradient forces are found to be one order of magnitude larger than scattering forces. Only the lower part of the cells is in contact with the evanescent field of the waveguide. For low refractive indices, we find that the lower 0.5-1 &mu;m of the cells is sufficient to determine the optical forces. For the cell sizes considered, all forces increase with the size.
Notch Signaling is Associated with ALDH Activity and an Aggressive Metastatic Phenotype in Murine Osteosarcoma Cells (2013)

Osteosarcoma (OS) is the most common primary malignancy of bone, and pulmonary metastatic disease accounts for nearly all mortality. However, little is known about the biochemical signaling alterations that drive the progression of metastatic disease. Two murine OS cell populations, K7M2 and K12, are clonally related but differ significantly in their metastatic phenotypes and therefore represent excellent tools for studying metastatic OS molecular biology. K7M2 cells are highly metastatic, whereas K12 cells display limited metastatic potential. Here we report that the expression of Notch genes (Notch1, 2, 4) are up-regulated, including downstream targets Hes1 and Stat3, in the highly metastatic K7M2 cells compared to the less metastatic K12 cells, indicating that the Notch signaling pathway is more active in K7M2 cells. We have previously described that K7M2 cells exhibit higher levels of aldehyde dehydrogenase (ALDH) activity. Here we report that K7M2 cell ALDH activity is reduced with Notch inhibition, suggesting that ALDH activity may be regulated in part by the Notch pathway. Notch signaling is also associated with increased resistance to oxidative stress, migration, invasion, and VEGF expression in vitro. However, Notch inhibition did not significantly alter K7M2 cell proliferation. In conclusion, we provide evidence that Notch signaling is associated with ALDH activity and increased metastatic behavior in OS cells. Both Notch and ALDH are putative molecular targets for the treatment and prevention of OS metastasis.
Regulatory region of the metA gene of Escherichia coli K-12 (1984)

Transcription of the metA gene of Escherichia coli K-12 is from a promoter which is under methionine control and is located next to a region which has an extensive sequence homology with the operator regions of the metBL and metF genes. However, in the metA gene there is a second transcription start point which is located 74 base pairs upstream and which is independent of the intracellular methionine concentration.
CMOS-Integrated 40GHz Germanium Waveguide Photodetector for On-chip Optical Interconnects (2009)

Compact (0.7μmx20μm) germanium waveguide photodetector operating at 40Gbps is demonstrated. Monolithic integration of high-quality Ge-on-insulator single-crystalline layer into the CMOS stack was achieved by lateral seeded crystallization during CMOS wells activation anneal above germanium melting temperature.
A case study of negative pressure wound therapy to manage acute necrotizing fasciitis. (2006)

Acute necrotizing fasciitis is a devastating infectious process that requires immediate surgical debridement. Intravenous antibiotic treatment, hyperbaric oxygen therapy, and wound management are considered the standard of care. Subsequent wound closure is achieved with split-thickness skin grafting, delayed surgical closure, or healing by secondary intention. When a patient refuses additional surgical treatment or is no longer a surgical candidate, as was the case with a patient who presented with acute necrotizing fasciitis caused by Clostridium perfringens in the upper extremity, secondary intention healing is the only treatment option. Following surgery and intravenous antibiotic treatment, her wounds were managed with topical negative pressure wound therapy. No adverse events occurred and the wounds were almost completely healed 63 weeks following surgery. Research to develop evidence-based protocols of care for the closure of these wounds is needed.
T‐Lymphocytes Contribute to Hepatic Leukostasis and Hypoxic Stress Induced by Gut Ischemia‐Reperfusion (1999)

Although neutrophils have been implicated in the hepatic injury elicited by gut ischemia/reperfusion (I/R), the contribution of other leukocyte populations to this injury process remains unclear. The objective of this study was to determine whether lymphocytes contribute to gut I/R-induced microvascular dysfunction and inflammatory responses in the liver. Intravital videomicroscopy was used to monitor leukocyte recruitment, the number of nonperfused sinusoids and pyridine nucleotide (NADH) autofluorescence in livers of wild-type, SCID, and interferon-gamma (IFN-gamma) knockout mice exposed to 15 min of gut ischemia and 1 h of reperfusion. In wild-type mice, gut I/R elicited significant increases in the number of stationary leukocytes, nonperfused sinusoids, NADH autofluorescence (indicating hypoxia), and elevated plasma alanine aminotransferase (ALT) and TNF-alpha levels. All of these responses were profoundly attenuated in SCID mice, while only some of the responses (in the midzonal region) were blunted in IFN-gamma knockout mice. Reconstitution (24 h before ischemia) of the circulating lymphocyte pool with T-cell enriched splenocytes, but not T cell deficient (from nude mice), CD4+ T-cell depleted splenocytes or splenocytes derived from IFN-gamma knockout mice, allowed the SCID mice to respond to gut I/R in a manner similar to wild-type mice. Some of the responses were restored following reconstitution with CD8+ T-cell depleted splenocytes. These findings implicate CD4+ T-lymphocytes and IFN-gamma in the hepatic microvascular dysfunction and inflammatory cell accumulation elicited by gut I/R.