gebhart/patrepeval huggingface dataset:
Optimal Transpiration Boundary Control for Aeroacoustics (2003)

We consider the optimal boundary control of aeroacoustic noise, governed by the two-dimensional unsteady compressible Euler equations. The control is the time- and space-varying wall normal velocity on a subset of an otherwise solid wall. The objective functional to be minimized is a measure of acoustic amplitude. Optimal transpiration boundary control of aeroacoustic noise introduces challenges beyond those encountered in direct aeroacoustic simulations or in many other optimization problems governed by compressible Euler equations. One nontrivial issue that arises in the optimal control problem is the formulation and implementation of transpiration boundary conditions. Because suction and blowing on the boundary are allowed, portions of the boundary may change from inflow to outflow, or vice versa, and different numbers of boundary conditions must be imposed at inflow vs outflow boundaries. Another important issue is the derivation of adjoint equations, which are required to compute the gradient of the objective function with respect to the control. Among other things, this is influenced by the choice of boundary conditions for the compressible Euler equations. The approaches to meet these challenges are described and results presented for three model problems. These problems are designed to validate the transpiration boundary conditions and their implementation, study the accuracy of gradient computations, and assess the performance of the computed controls.
Direct and cell signaling-based, geometry-induced neuronal differentiation of neural stem cells (2011)

Neural Stem Cells (NSCs) are multipotent precursors inhabiting the subventricular and hippocampal subgranular regions of the adult mammalian brain, able to self-renew and differentiate into neurons, astrocytes, and oligodendrocytes, the three primary neural cell types of the adult brain. NSC fate is influenced by the physical and chemical microenvironment experienced by the cell, both in vitro and in vivo. Towards characterizing the influence of topographical, geometric cues on NSC fate, we fabricated highly aligned, single- and double-layer polystyrene nanofiber meshes. Seeding of NSCs on laminin-coated fibers induces polarized NSC morphology and cellular elongation in the directions of fiber alignment, with cells extending membranous processes over hundreds of microns along the fiber surfaces. Additionally, these aligned fiber substrates promote neuronal lineage specification of NSCs with an efficiency of 82.3 ± 11.1% within days of seeding. Moreover, not only do cells on fibers yield neurons, but also neighboring cells in close proximity to those differentiating on aligned fibers, with an efficiency of 72.8 ± 9.7%. This neighboring, cell-induced differentiation occurs without cell-cell contact over millimetres away from the fibers, suggesting a paracrine signaling effect not previously reported for NSCs undergoing neurogenesis. In contrast, NSCs farther away from these fiber substrates nearly uniformly yield glia.
An efficient algorithm for the optimization of FIR filters synthesized using the multistage frequency-response masking approach (2004)

A very efficient technique to drastically reduce the number of multipliers and adders in narrow transition-band linear-phase finite-impulse response digital filters is to use the one-stage or multistage frequency-response masking (FRM) approach originally introduced by Y.C. Lim (see ibid.,1986). In the original synthesis techniques developed by Lim and Lian (see ibid.,1993), the subfilters in the overall implementation are separately designed. As shown earlier by the first two authors of this contribution as well as Johansson, the arithmetic complexity in the one-stage FRM filter designs can be considerably reduced by using the following two-stage technique for simultaneously optimizing all subfilters. First, a suboptimal solution is found by using a simple design scheme. Second, this solution is used as a start-up solution for further optimization being carried out by an efficient unconstrained nonlinear optimization algorithm. This paper exploits this approach for synthesizing multistage FRM filters. An example taken from the literature illustrates that both the number of multipliers and the number of adders for the resulting optimized FRM filters are approximately 70 percent compared with those of the filters synthesized using the original multistage FRM filter design schemes.
ChemInform Abstract: New Rhodium Complexes Anchored on Modified USY Zeolites. A Remarkable Effect of the Support on the Enantioselectivity of Catalytic Hydrogenation of Prochiral Alkenes. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Hydroamination of Aromatic Alkynes to Imines Catalyzed by Pd(II)–Anthraphos Complexes (2020)

International audience
3-D Integrated Chiplet Encapsulation (3-D ICE): High-Density Heterogeneous Integration Using SiO2-Reconstituted Tiers (2021)

We propose a 3-D heterogeneous integration technology called three-dimensional integrated chiplet encapsulation (3-D ICE). The proposed 3-D ICE architecture encapsulates chiplets into a reconstituted tier using low-temperature (100 °C) inductively coupled plasma-enhanced chemical vapor deposition (ICP-PECVD) SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> deposition. The SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> -reconstituted tier in this work is 10- <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\mu \text{m}$ </tex-math></inline-formula> thick with through-oxide vias (TOVs) that are <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$2 ~\mu \text{m}$ </tex-math></inline-formula> in diameter and <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$10 ~\mu \text{m}$ </tex-math></inline-formula> in pitch (10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sup> /mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> via density), which exceeds vias in conventional fan-out packaging. Tier transferring using KOH wet etch is also reported. Finally, the four-point Kelvin resistance measurements are performed for Cu-filled TOVs of various dimensions. The resistance of a 50- <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\mu \text{m}$ </tex-math></inline-formula> -diameter single via is 36 <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\text{m}\Omega $ </tex-math></inline-formula> and that of a 2- <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\mu \text{m}$ </tex-math></inline-formula> -diameter via is <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$1.14 \Omega $ </tex-math></inline-formula> .
Intersectin, an Adaptor Protein Involved in Clathrin-mediated Endocytosis, Activates Mitogenic Signaling Pathways (2000)

Intersectin is a member of a growing family of adaptor proteins that possess conserved Eps15 homology (EH) domains as well as additional protein recognition motifs. In general, EH domain-containing proteins play an integral role in clathrin-mediated endocytosis. Indeed, intersectin functions in the intermediate stages of clathrin-coated vesicle assembly. However, recent evidence suggests that components of the endocytic machinery also regulate mitogenic signaling pathways. In this report, we provide several lines of evidence that intersectin has the capacity to activate mitogenic signaling pathways. First, intersectin overexpression activated the Elk-1 transcription factor in an MAPK-independent manner. This ability resides within the EH domains, as expression of the tandem EH domains was sufficient to activate Elk-1. Second, intersectin cooperated with epidermal growth factor to potentiate Elk-1 activation; however, a similar level of Elk-1 activation was obtained by expression of the tandem EH domains suggesting that the coiled-coil region and SH3 domains act to regulate the EH domains. Third, intersectin expression was sufficient to induce oncogenic transformation of rodent fibroblasts. And finally, intersectin cooperated with progesterone to accelerate maturation of <i>Xenopus laevis</i> oocytes. Together, these data suggest that intersectin links endocytosis with regulation of pathways important for cell growth and differentiation.
Detection and removal of binocular luster in compressed 3D images (2011)

Binocular luster is an extremely salient effect seen in 3D when an object in each stereo image exhibits a different contrast polarity relative to the background. The object appears to shimmer, a phenomenon seen in nature and on 3D displays, which the Human Visual System rapidly detects. This binocular luster is also induced by compression of stereo imagery where corresponding blocks are quantized to different values. In this paper, we discuss the psychovisual background of binocular luster, introduce the "shine" artifact induced by compression, and present an algorithm for detection and removal of shine from JPEG compressed stereo images without introducing additional bitrate.
Erratum (2010)

a miniature electronic biosensor for glycan biomarker detection (Nanomedicine 5[
The detection of loose bodies in the elbow (2005)

Our aim was to determine the clinical value of MRI and CT arthrography in predicting the presence of loose bodies in the elbow. A series of 26 patients with mechanical symptoms in the elbow had plain radiography, MRI and CT arthrography, followed by routine arthroscopy of the elbow. The location and number of loose bodies determined by MRI and CT arthrography were recorded. Pre-operative plain radiography, MRI and CT arthrography were compared with arthroscopy. Both MRI and CT arthrography had excellent sensitivity (92% to 100%) but low to moderate specificity (15% to 77%) in identifying posteriorly-based loose bodies. Neither MRI nor CT arthrography was consistently sensitive (46% to 91%) or specific (13% to 73%) in predicting the presence or absence of loose bodies anteriorly. The overall sensitivity for the detection of loose bodies in either compartment was 88% to 100% and the specificity 20% to 70%. Pre-operative radiography had a similar sensitivity and specificity of 84% and 71%, respectively. Our results suggest that neither CT arthrography nor MRI is reliable or accurate enough to be any more effective than plain radiography alone in patients presenting with mechanical symptoms in the elbow.
Tn and STn are members of a family of carbohydrate tumor antigens that possess carbohydrate–carbohydrate interactions (2018)

The mucin-type O-glycome in cancer aberrantly expresses the truncated glycans Tn (GalNAcα1-Ser/Thr) and STn (Neu5Acα2,6GalNAcα1-Ser/Thr). However, the role of Tn and STn in cancer and other diseases is not well understood. Our recent discovery of the self-binding properties (carbohydrate-carbohydrate interactions, CCIs) of Tn (Tn-Tn) and STn (STn-STn) provides a model for their possible roles in cellular transformation. We also review evidence that Tn and STn are members of a larger family of glycan tumor antigens that possess CCIs, which may participate in oncogenesis.
Development of a second generation linkage map for almond using RAPD and SSR markers (2000)

Fifty-four RAPD (random amplified polymorphic DNA) markers and 6 SSRs (simple sequence repeats) were included in a molecular marker map with 120 RFLPs (restriction fragment length polymorphisms) and 7 isozyme genes previously constructed using the offspring of a cross between the almond (Prunus amygdalus) cultivars 'Ferragnès' and 'Tuono'. Only highly reproducible RAPDs segregating 1:1 were used. To identify these markers, a total of 325 primers were screened, from which 41 produced RAPDs useful for mapping. Polymorphism was detected in six of the eight Prunus SSRs (simple sequence repeats) studied, thus enabling these to be mapped. All markers were placed on the 8 linkage groups previously identified. The number of new markers included in the map of 'Ferragnès' was 33 for a total of 126, and 30 in the map of 'Tuono' for a total of 99. The sizes of the maps of 'Ferragnès' (415 cM) and 'Tuono' (416 cM) were similar, representing a 5% increase over the maps constructed solely with isozymes and RFLPs. The estimated total size of the almond map was of 457 cM. Some markers were placed in zones with low density of markers and others in the extreme of linkage groups. The use of RAPD markers to complete genetic maps constructed with transferable markers is discussed.
The parallel, time-dependent, bimodal change in lymphocyte cholinergic binding activity and cholinergic influence upon lymphocyte-mediated cytotoxicity after lymphocyte activation. (1981)

The potent muscarinic cholinergic antagonist 3-quinuclidinyl benzilate has been used to detect muscarinic acetylcholine receptors on rodent and human lymphocytes. Binding to B lymphocytes was minimal and was not saturable or ligand specific. Half-maximal binding of (3H)-quinuclidinyl benzilate to T lymphocytes occurred at concentrations comparable to those described in other systems, and was displaceable at physiologic concentrations by muscarinic but not nicotinic agonists and antagonists. Binding to T lymphocytes was both saturable and specific, and was found to rapidly increase significantly after mitogen activation. Activation of T lymphocytes or the Lyt 1+ subset produces an early increase and later fall in muscarinic binding, and the ability od cholinergic agonists to augment the effector function of cytotoxic T lymphocytes harvested from alloimmune rat spleen is directly related to the magnitude of muscarinic binding.
Immunomodulation of experimental colitis: the role of NK1.1 liver lymphocytes and surrogate antigens – bystander effect (2001)

The imbalance between Th1 pro-inflammatory and Th2 anti-inflammatory cytokine-producing cells plays a major role in the pathogenesis of inflammatory bowel disease (IBD). Induction of oral tolerance to colitis-extracted proteins was previously shown to down-regulate the anti-colon immune response, thereby alleviating experimental colitis. Immune bystander effect and liver-associated lymphocytes expressing the NK1.1 marker (NK1.1(+) LAL) have been suggested as being important in tolerance induction. The aims of the present study were to determine whether oral administration of inflammatory and non-inflammatory colon-extracted proteins of different species can induce peripheral immune tolerance and alleviate experimental colitis; and to examine the role of NK1.1(+) LAL in oral tolerance induction. Colitis was induced in C57/B6 mice by intracolonic instillation of trinitrobenzene sulphonic acid (TNBS). Mice received six oral doses of colonic proteins extracted from TNBS-colitis colonic wall, or normal colonic wall, from four different species. Standard clinical, macroscopic, and microscopic scores were used for colitis assessment. Serum interferon gamma (IFNgamma) and interleukin 10 (IL10) levels were measured by ELISA. To evaluate the role of NK1.1(+) LAL in maintaining the balance between immunogenic and tolerogenic subsets of cells, their cytotoxicity functions were tested in tolerized and non-tolerized-mice. The administration of mouse-derived colitis-extracted proteins, or of surrogate proteins extracted from normal mouse colon, or from rat or human inflammatory colons, was found to alleviate experimental colitis. Tolerized mice had less diarrhoea; showed a marked reduction of colonic ulceration, intestinal and peritoneal adhesions, wall thickness, and oedema; and demonstrated a significant improvement of all microscopic parameters for colitis. Induction of tolerance led to an increase in IL10 and a decrease in IFNgamma serum levels. NK1.1(+) LAL cytotoxicity function increased markedly in tolerized mice. In contrast, mice fed with proteins extracted from normal rat, rabbit, and human colon, or from rabbit inflammatory colon, developed severe colitis, with a marked increase in IFNgamma and a decrease in IL10 serum levels, and down-regulation of NK1.1(+) LAL function. This study has shown that oral tolerance can be induced in experimental colitis by means of the feeding of surrogate antigens; this alleviates experimental colitis. NK1.1(+) LAL cytotoxicity function is associated with peripheral tolerance induction and may help to maintain the Th1/Th2 immune balance.
Absence of oncogenic canonical pathway mutations in aggressive pediatric rhabdoid tumors (2012)

The absence of mutations in canonical pathways critical for development and progression of adult cancers suggests that distinct mechanisms drive these highly malignant pediatric tumors. This may limit the therapeutic utility of available targeted therapies and require a refocusing toward developmental and epigenetic pathways.
Influence of plasminogen activator inhibitor type 1 on choroidal neovascularization (2001)

ABSTRACT High levels of the plasminogen activators, but also their inhibitor, plasminogen activator inhibitor 1 (PAI‐1), have been documented in neovascularization of severe ocular pathologies such as diabetic retinopathy or age‐related macular degeneration (AMD). AMD is the primary cause of irreversible photoreceptors loss, and current therapies are limited. PAI‐1 has recently been shown to be essential for tumoral angiogenesis. We report here that deficient PAI‐1 expression in mice prevented the development of subretinal choroidal angiogenesis induced by laser photocoagulation. When systemic and local PAI‐1 expression was achieved by intravenous injection of a replication‐defective adenoviral vector expressing human PAI‐1 cDNA, the wild‐type pattern of choroidal angiogenesis was restored. These observations demonstrate the proangiogenic activity of PAI‐1 not only in tumoral models, but also in choroidal experimental neovascularization sharing similarities with human AMD. They identify therefore PAI‐1 as a potential target for therapeutic ocular anti‐angiogenic strategies.—Lambert, V., Munaut, C., Noel, A., Frankenne, F., Bajou, K., Gerard, R., Carmeliet, P., Defresne, M. P., Foidart, J.‐M., Rakic, J.‐M. Influence of plasminogen activator inhibitor type 1 on choroidal neovascularization. FASEB J. 15, 1021–1027 (2001).
SpeckleEye (2012)

We introduce SpeckleEye, design and implementation of an embedded gesture and real-time motion tracking system using laser speckle. SpeckleEye is a low-cost, scalable, open source toolkit for embedded speckle sensing and gestural interaction with ubiquitous devices in the environment. We describe embedded speckle sensing hardware and firmware, a cross-platform gesture recognition library optimized to run on embedded processors, and a set of prototypes that illustrate the flexibility of our platform.
Cyclostationary feature detection from sub-Nyquist samples (2011)

Wideband spectrum sensing which requires detecting the presence or absence of signals in a wideband channel faces multiple practical issues. Current bandwidth limitations of state-of-the-art analog to digital converters require alternative approaches to be considered for wideband sensing. Cyclostationary feature detection is a promising sensing tool which is robust to noise, and takes advantage of the noise stationarity. In this paper, we propose a cyclostationary feature detector that operates on sub-Nyquist samples obtained via either multicoset sampling or the modulated wideband converter analog front-end, and present the receiver's detection performance at low SNRs.
PLC/PRF/5 (Alexander) hepatoma cell line: further characterization and studies of infectivity (1980)

The Alexander hepatoma cell line, PLC/PRF/5, was studied for evidence of hepatitis B virus markers and alpha-fetoprotein. Only hepatitis B surface antigen and alpha-fetoprotein were detected. Induction experiments with 5-iodo-2'-deoxyuridine and inoculation of chimpanzees with whole cells or tissue culture fluid did not reveal evidence of synthesis of additional hepatitis B virus markers or of production of infectious virus.
Synchronization of environmentally coupled, passively mode-locked fiber lasers (1996)

Summary form only given. Synchronization of mode-locked lasers has become a subject of increasing interest lately due to the utilization of ultrafast lasers in communications systems, pump-probe measurements, and other applications. Commercial systems have been developed for synchronizing mode-locked Ti:sapphire lasers to an external source or to other mode-locked lasers. Here, we report the synchronization of two passively mode-locked Er:fiber lasers to an accuracy of 5 psec RMS.
Set-up and experimental validation of a peak torque feeding algorithm for electrical drives (2004)

This paper is mainly devoted to the analysis of feeding algorithms, that can be successfully used for road vehicles. Based on the assumption that traction drives for those vehicles must privilege saving of energy and high energy recovery capability, authors compare performances of traditional FO with another feeding algorithm defined as PT (peak torque). For exhaustive exemplification, reference is made to saturated operations of traditionally designed asynchronous traction motors. Results of numerical and theoretical analysis show that PT algorithm is more profitable for application in traction drives for road vehicles. Experimental results, carried out by a sample drive, support theoretical results.
pyGenClean: efficient tool for genetic data clean up before association testing (2013)

pyGenClean is an open source Python 2.7 software and is freely available, along with documentation and examples, from http://www.statgen.org.
Low-power continuous-wave four-wave mixing in silicon coupled-resonator optical waveguides (2011)

We demonstrate four-wave mixing in silicon-on-insulator coupled-resonator optical waveguides consisting of 35 and 65 microring resonators, using a cw pump with coupled power below 20 mW and observed parametric conversion across more than 10 THz. The conversion efficiency is enhanced by +16 dB relative to a silicon straight waveguide of equivalent length, due to the slowing factor of the coupled-resonator structure.
Melody recognition by two-month-old infants (2009)

Music is part of an infant's world even before birth, and caregivers around the world sing to infants. Yet, there has been little research into the musical abilities or preferences of infants younger than 5 months. In this study, the head turn preference procedure used with older infants was adapted into an eye-movement preference procedure so that the ability of 2-month-old infants to remember a short melody could be tested. The results show that with minimal familiarization, 2-month-old infants remember a short melody and can discriminate it from a similar melody.