gebhart/patrepeval huggingface dataset:
Experimental and Computational Investigations of Carboplatin Supramolecular Complexes (2020)

Supramolecular systems (macromolecules), such as calix[<i>n</i>]arenes (SCn), cyclodextrins (CDs), and cucurbiturils (CBs), are promising vehicles for anticancer drugs. In this work, guest-host complexes of carboplatin, a second-generation platinum-based anticancer drug, and p-4-sulfocalix[<i>n</i>]arenes (<i>n</i> = 4 and 6; PS4 and PS6, respectively) were prepared and studied using <sup>1</sup>H NMR, UV, Job's plot analysis, HPLC, and density-functional theory calculations. The experimental and the computational studies suggest the formation of 1:1 complexes between carboplatin and each of PS4 and PS6. The stability constants of the formed complexes were estimated to be 5.3 × 10<sup>4</sup> M<sup>-1</sup> and 9.8 × 10<sup>4</sup> M<sup>-1</sup>, which correspond to free energy of complexation of -6.40 and -6.81 kcal mol<sup>-1</sup>, in the case of PS4 and PS6, respectively. The interaction free energy depends on the different inclusion modes of carboplatin in the host cavities. UV-vis findings and atoms in molecules analysis showed that hydrogen bond interactions stabilize the host-guest complexes without the full inclusion in the host cavity. The in vitro anticancer study revealed that both complexes exhibited stronger anticancer activities against breast adenocarcinoma cells (MCF-7) and lung cancer cells (A-549) compared to free carboplatin, preluding to their potential use in cancer therapy.
Search for triboson $$W^{\pm }W^{\pm }W^{\mp }$$ W ± W ± W ∓ production in pp collisions at $$\sqrt{s}=8$$ s = 8 $$\text {TeV}$$ TeV with the ATLAS detector (2017)

This paper reports a search for triboson [Formula: see text] production in two decay channels ([Formula: see text] and [Formula: see text] with [Formula: see text]) in proton-proton collision data corresponding to an integrated luminosity of 20.3 [Formula: see text] at a centre-of-mass energy of 8 [Formula: see text] with the ATLAS detector at the Large Hadron Collider. Events with exactly three charged leptons, or two leptons with the same electric charge in association with two jets, are selected. The total number of events observed in data is consistent with the Standard Model (SM) predictions. The observed 95% confidence level upper limit on the SM [Formula: see text] production cross section is found to be 730 fb with an expected limit of 560 fb in the absence of SM [Formula: see text] production. Limits are also set on <i>WWWW</i> anomalous quartic gauge couplings.
Three-Dimensional Self-Assembly of Complex, Millimeter-Scale Structures through Capillary Bonding (2001)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTThree-Dimensional Self-Assembly of Complex, Millimeter-Scale Structures through Capillary BondingScott R. J. Oliver, Thomas D. Clark, Ned Bowden, and George M. WhitesidesView Author Information Department of Chemistry and Chemical Biology Harvard University, 12 Oxford Street Cambridge, Massachusetts 02138 Cite this: J. Am. Chem. Soc. 2001, 123, 33, 8119–8120Publication Date (Web):July 25, 2001Publication History Received2 April 2001Published online25 July 2001Published inissue 1 August 2001https://pubs.acs.org/doi/10.1021/ja010845qhttps://doi.org/10.1021/ja010845qrapid-communicationACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views527Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Alloys,Chemical structure,Copper,Molecular structure,Self organization Get e-Alerts
Transfer of vascularized lymph node tissue (2020)

In contrast to more conventional treatments such as extensive skin resection and liposuction, recent focus has been on techniques for lymphatic bypass, transfer of lymphatic groin tissue attached to abdominal free flaps used for breast reconstruction, or transfer of vascularized lymph nodes. Vascularized lymph node flap transfer is a surgical therapy for lymphedema, which can be applied after conservative therapies have been attempted. Histologic findings of progressive reduction of lymphatic function and decrease of distal lymph-collecting ducts following proximal injury are due to loss of contractility within the lymphatic vasculature9 and disruption of valve system function. The greater number of lymph nodes in a vascularized lymph node flap results in a more efficient reduction of lymphedema. The transfer of a vascularized groin or submental lymph node flap is an evidence-based approach for the effective treatment of persistent extremity lymphedema which has not responded to conservative therapy.
ChemInform Abstract: New Polymer‐Supported Cinchona Alkaloids for Heterogeneous Catalytic Asymmetric Dihydroxylation of Olefins. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Expression of integrins and E-cadherin in squamous cell carcinomas of the head and neck (2004)

Integrins and cadherins are cell adhesion molecules suggested to play an important role in malignant progression and tumour differentiation. Our aim was to characterise the pattern of expression and the relations between integrin beta1, beta4, beta6 and E-cadherin and the different histopathological features important when judging tumour differentiation, using a well-defined scoring system. Formalin-fixed paraffin-embedded pre-irradiation biopsies from 85 patients with head and neck squamous cell carcinomas (HNSCC) were stained and evaluated for the expression of integrin beta1, beta4 and beta6 and E-cadherin. The integrins were upregulated in carcinomas compared to the adjacent mucosa and E-cadherin was downregulated. However, differences were found within the tumour: Expression of E-cadherin was lost and the three integrins were upregulated at the tumour borders, compared to central parts of the tumour biopsy. Expression of the integrins did not correlate with tumour or histopathological parameters, whereas expression of E-cadherin was correlated with high degree of keratinisation, high nuclear maturation and few mitoses - factors that characterise well-differentiated carcinomas -and E-cadherin can therefore be considered as a marker of differentiation. Furthermore, loss of adhesion expressed by low E-cadherin and integrin beta4 correlated with the presence of nodal metastases at the time of diagnosis.
1712 Fundamental study of multiple measurement system using ultrasound, electrical conduction and image processing for two-phase flow measurement(2) (2006)

To measure the main parameter of the gas-liquid two-phase flow at the same time, the compound measurement system was developed. The compound measurement system is composed of Ultrasonic Time-Domain Correlation method (UTDC), Wire Mesh Tomography (WMT), and Digital Image Processing (DIP). UTDC and high-speed camera were introduced for a more detailed measurement of the gas-liquid two-phase flow. As a result, the monitor of the gas-liquid two-phase flow became possible. The bubbly flow adapts the compound measurement system in this research. Furthermore, the each parameter effects for bubbly flow structures are clarified using the compound measurement system.
Theoretical model for a background noise limited laser-excited optical filter for doubled Nd lasers (1990)

A simple theoretical model for the calculation of the dependence of filter quantum efficiency versus laser pump power in an atomic Rb vapor laser-excited optical filter is reported. Calculations for Rb filter transitions that can be used to detect the practical and important frequency-doubled Nd lasers are presented. The results of these calculations show the filter's quantum efficiency versus the laser pump power. The required laser pump powers required range from 2.4 to 60 mW/cm/sup 2/ of filter aperture.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Enhanced Optical Sensitivity in Thermoresponsive Photonic Crystal Hydrogels by Operating Near the Phase Transition (2017)

Photonic crystal hydrogels composed of analyte-responsive hydrogels and crystalline colloidal arrays have immense potential as reagentless chemical and biological sensors. In this work, we investigated a general mechanism to rationally tune the sensitivity of photonic crystal hydrogels consisting of stimuli-responsive polymers to small molecule analytes. This mechanism was based on modulating the demixing temperature of such hydrogels relative to the characterization temperature to in effect maximize the extent of phase separation behavior; thus, the volume changes in response to the target analytes. Using ethanol as a model analyte, we demonstrated that this mechanism led to a dramatic increase in the sensitivity of optically diffracting poly(N-isopropylacrylamide) (pNIPAM) hydrogel films that exhibit a lower critical solution temperature (LCST) behavior. The demixing temperature of the pNIPAM films was modulated by copolymerization of the films with relatively hydrophobic and hydrophilic comonomers, as well as by varying the ionic strength of the characterization solution. Our results showed that copolymerization of the films with 2.5 mol % of N-tert-butylacrylamide, which is hydrophobic relative to pNIPAM, enabled the detection limit of the pNIPAM films to ethanol to be lowered ∼2-fold at 30 °C. Additionally, increasing the ionic strength of the characterization solution above 200 mM resulted in a dramatic increase in the extent of contraction of the films in the presence of ethanol. Ultimately, it was demonstrated that as little as 16 g/L or 2 vol % of ethanol in water could reliably be detected, and that the sensitivity of the films to ethanol was predictably greatest when operating near the phase transition, such that even small additions of the analyte induced the start of demixing and the collapse of the hydrogel. Such a mechanism may be extended to photonic crystal hydrogel sensors prepared from other stimuli-responsive polymers and more broadly exploited to enhance the utility of these sensors for a broad range of analytes.
Optical Bragg Diffraction of the Helical Smectic A Liquid Crystal (1992)

Abstract Optical properties of the mixture of cholesteryl-n-nonanoate (CN) and n-nonyloxybenzoic acid (NOBA) in weight proportion 7:3 have been investigated. As it was early found by us (Ukranian Fiz. Zhurn., 35, 221 (1990)) this mixture possesses a new liquid-crystalline helical smectic A (SmA*) phase between the low-temperature smectic A (SmA) and high-temperature cholesteric (Ch) phases. It is shown experimentally that there are three temperature regions of the optical Bragg diffraction for the mixture. The first two regions correspond to the different states of the SmA* phase and the third one corresponds to the Ch phase. Inside each region the temperature dependence of the Bragg reflection wavelength γ is in exellent agreement with an empirical formula γ = γ0 + a/(T − T*)2, where T* = 82.4°C is the temperature of the SmA − SmA* transition and γ0 as well as a are constant within each region but differ for different regions.
β-Arrestin 1 down-regulation after insulin treatment is associated with supersensitization of β2 adrenergic receptor Gαs signaling in 3T3-L1 adipocytes (2002)

beta-Arrestin 1 is required for internalization and mitogen-activated protein (MAP) kinase activation by the beta2 adrenergic receptor (beta2AR). Our previous studies have shown that chronic insulin treatment down-regulates cellular beta-arrestin 1 levels, leading to a marked impairment in G protein-coupled receptor and insulin-like growth factor-1 receptor-mediated MAP kinase and mitogenic signaling. In this study, we show that chronic insulin-treated, beta-arrestin 1depleted 3T3-L1 adipocytes display (i) increased isoproterenol-induced cAMP generation (53 +/- 38% at 1.5 min, 25 +/- 19% at 5 min, 63 +/- 14% at 30 min, and 59 +/- 2% at 60 min), a Galpha(s)-associated pathway; (ii) impaired isoproterenol-induced beta2AR internalization (reduced by 98 +/- 4%), which is required for MAP kinase signaling, a Galpha(i)-associated pathway; and (iii) increased beta-arrestin 1 phosphorylation at Ser-412. Taken together, these findings represent a hitherto unknown mechanism (degradation and phosphorylation of beta-arrestin, whereby the activation of the insulin receptor, belonging to the family of receptor tyrosine kinases, causes supersensitization of Galpha(s)-associated signaling and inhibition of Galpha(i)-associated signaling by the beta2AR, a prototypical G protein-coupled receptor.
Using Local Information in a Non-Local Way for Mapping Graph-Like Worlds. (1993)

This paper describes a technique whereby an autonomous agent such as a mobile robot can explore an unknown environment and make a topological map of it. It is assumed that the environment can be represented as a graph, that is, as a fixed set of discrete locations or regions with an ordered set of paths between them. In previous work, it has been shown that such worlds can be fully explored and described using a single movable marker even if there are no spatial metrics and almost no sensory ability on the part of the robot. Here we present an approach to the exploration of unknown worlds without such a movable marker which is simply based on the structure of the world itself. Locations in the world are identified by a nonunique &amp;quot;signature&amp;quot; that serves as an abstraction for a percept that might be obtained from a robotic sensor. While the signature of any single location may not be unique, under appropriate conditions the distinctiveness of a particular set of signatures in a neighborh...
Structural Study of Hydrated Organic Mixed Ionic Electronic Conductors Using Cryogenic 4D-STEM (2023)

Journal Article Structural Study of Hydrated Organic Mixed Ionic Electronic Conductors Using Cryogenic 4D-STEM Get access Yael Tsarfati, Yael Tsarfati National Center for Electron Microscopy, Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA, USADepartment of Materials Science and Engineering, University of California, Berkeley, CA, USADepartment of Materials Science and Engineering, Stanford University, CA, USA Search for other works by this author on: Oxford Academic Google Scholar Karen C Bustillo, Karen C Bustillo National Center for Electron Microscopy, Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA, USA Search for other works by this author on: Oxford Academic Google Scholar Benjamin H Savitzky, Benjamin H Savitzky National Center for Electron Microscopy, Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA, USA Search for other works by this author on: Oxford Academic Google Scholar Colin Ophus, Colin Ophus National Center for Electron Microscopy, Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA, USA Search for other works by this author on: Oxford Academic Google Scholar Iain McCulloch, Iain McCulloch University of Oxford, Department of Chemistry, UK Search for other works by this author on: Oxford Academic Google Scholar Alberto Salleo, Alberto Salleo Department of Materials Science and Engineering, Stanford University, CA, USA Corresponding authors: aminor@berkeley.edu, asalleo@stanford.edu Search for other works by this author on: Oxford Academic Google Scholar Andrew M Minor Andrew M Minor National Center for Electron Microscopy, Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA, USADepartment of Materials Science and Engineering, University of California, Berkeley, CA, USA Corresponding authors: aminor@berkeley.edu, asalleo@stanford.edu Search for other works by this author on: Oxford Academic Google Scholar Microscopy and Microanalysis, Volume 29, Issue Supplement_1, 1 August 2023, Pages 264–265, https://doi.org/10.1093/micmic/ozad067.119 Published: 22 July 2023
Cooperative capacity-achieving precoding design for multi-user VFDM transmission (2014)

In this paper, we study cooperative precoder design in two-tier networks, consisting of a macro cell (MC) and small cells (SCs). By exploiting multi-user Vandermonde-subspace frequency division multiplexing (VFDM) transmission, a MC downlink can co-exist with cognitive SCs. In this paper, we first propose a cooperative cross-tier precoder (CTP) among the transmitters in the SCs to increase the transmit dimension. Moreover, the cooperative CTP allows us to use more efficient intra-tier precoder (ITP) in the SCs to handle intra-cell interference and improve the throughput of the cognitive system. And then, a capacity-achieving (CA) ITP is developed. Numerical results are presented to demonstrate the throughput improvement of the proposed scheme and the robustness to the channel estimation error.
High-Speed Bolometry Based on Johnson Noise Detection of Hot Electrons in Cavity-Coupled Graphene (2017)

Since the invention of the bolometer, its main design principles relied on efficient light absorption into a low-heat-capacity material and its exceptional thermal isolation from the environment. While the reduced thermal coupling to its surroundings allows for an enhanced thermal response, it in turn strongly reduces the thermal time constant and dramatically lowers the detector's bandwidth. With its unique combination of a record small electronic heat capacity and a weak electron-phonon coupling, graphene has emerged as an extreme bolometric medium that allows for both, high sensitivity and high bandwidths. Here, we introduce a hot-electron bolometer based on a novel Johnson noise readout of the electron gas in graphene, which is critically coupled to incident radiation through a photonic nanocavity. This proof-of-concept operates in the telecom spectrum, achieves an enhanced bolometric response at charge neutrality with a noise equivalent power NEP < 5pW/ Sqrt(Hz), a thermal relaxation time of {\tau} < 34ps, an improved light absorption by a factor ~3, and an operation temperature up to T=300K.
Advanced Nanostructured Catalysts For Efficient In-Cabin Air Purification (2019)

Tanya Shirman, Harvard University, USA
DSP technologies in the Stokes vector receivers for short-reach optical transmission systems (2018)

Stokes vector receivers have attracted attention for their ability to enhance spectral efficiency due to the increase in the number of dimensions compared to conventional intensity-modulation and direct-detection (IM-DD) systems. One of the technical advantages of the Stokes receiver is that the original state-of-polarization (SOP) of a transmitted signal can be retrieved with digital signal processing (DSP) even if it is fluctuated during fiber transmission. In this paper, we review DSP technologies for SOP recovery, focusing on the modified constant modulus algorithm (CMA), and the radius directed equalization (RDE) algorithm in the Stokes space. Using computer simulations, we show that these algorithms can track random SOP fluctuations without any penalties.
David Ogilvie White (2005)

Medical virologist, 30 August 1931 ? 7 November 2004
Field Evaluation of Transmit Diversity Code Filter Sets in ATSC 3.0 Single Frequency Networks (2021)

Advanced Television Systems Committee (ATSC) 3.0, a recently developed terrestrial broadcasting standard, supports a Single Frequency Network (SFN), which extends service coverage and enhances received field strength without additional frequency resources. In SFN, multiple transmitters emit identical ATSC 3.0 broadcasting signals, which may cause constructive or destructive interference on a receiver side. The worst situation occurs when two signals from different transmitters are received with the opposite phase and similar power within a sample time, causing the cancellation of the received signal. In order to prevent such signal cancellation, ATSC 3.0 adopted transmitter diversity code filter sets (TDCFS), which is a frequency domain pre-distortion scheme to minimize cross-correlation among multiple transmitter signals in SFN. This paper sets up an ATSC 3.0 SFN consisting of two transmitter sites, transmitting high definition (HD) for mobile service and 4K ultra high definition (UHD) for fixed service. Layered division multiplexing (LDM) and time division multiplexing (TDM) are used to simulcast the two services with different robustness in the same radio frequency (RF) channel. Then, performance is evaluated using a threshold of visibility (ToV) and a successful reception rate. The time and frequency channel responses are changed at the same reception area when TDCFS is applied so the results show that reception performance is improved in the worst situation in SFN.
<title>Stereo Texture Facades</title> (1996)

This paper describes new ways of using textures to substitute for complex geometric models. A stereo texture is a stereo pair of images mapped onto geometry and presented in a stereo display. The viewer sees the stereo pair and can thus perceive depth information in the textured image. This technique can be used to replace large parts of a complex model with simple base geometry and a stereo texture. The stereo textures can replace the scene beyond a frame or portal. If the stereo texture is placed some distance behind the frame, the viewer gets motion parallax, between the frame and the scene. The textures may also contain information in association with the image for tasks such as picking.