gebhart/patrepeval huggingface dataset:
High-power highly efficient wavelength stabilized pumps operating in 8xx-9xx nm range (2022)

Solid State and Fiber Lasers performance benefits from utilizing highly efficient high brightness wavelength-stabilized pumps. Full wavelength locking in the wide range of operating current and heatsink temperature significantly simplifies overall construction of the Solid State and Fiber Lasers. Thus, stability of lasing wavelength against current and temperature variation has recently become an additional imperative requirement. We report on high power multimode pumps that operate at 878.6nm and 975nm. We discuss on chips’ and packaged pumps’ performance that features high power conversion efficiency (PCE) (up to 60% ex-fiber) and full wavelength locking (40-45 dB) in the wide range of driving current. Laser diode chip and packaged pump devices are produced by high-volume scalable technology which ensures full wavelength stabilization in the wide range of heatsink temperatures (10°C to 50°C range). We present performance of several 878.6nm pump models rated to operate reliably in 30W-120W power range as well as performance of 975nm pumps designed for high efficiency operation at elevated temperature.
Global assessment of arteriolar, venular and capillary changes in normal tension glaucoma (2020)

Microcirculatory insufficiency has been hypothesized in glaucoma pathogenesis. There is a scarcity of data to comprehensively examine the changes in retinal microvasculature and its role in normal tension glaucoma (NTG). We conducted a cross-sectional case-control study and included 168 eyes from 100 NTG patients and 68 healthy subjects. Quantitative retinal arteriolar and venular metrics were measured from retinal photographs using a computer-assisted program. Radial peripapillary capillary network was imaged with OCT-A and quantitative capillary metrics (circumpapillary vessel density (cpVD) and circumpapillary fractal dimension (cpFD)) were measured with a customized MATLAB program. We found that NTG was associated with decreased arteriolar and venular tortuosity, arteriolar branching angle, cpVD and cpFD. Decreased venular caliber, arteriolar and venular branching angles, cpVD and cpFD were associated with thinner average RNFL thickness. Decreased arteriolar and venular branching angles, cpVD and cpFD were also associated with worse standard automated perimetry measurements (mean deviation and visual field index). Compared with retinal arteriolar and venular metrics, regression models based on OCT-A capillary metrics consistently showed stronger associations with NTG and structural and functional measurements in NTG. We concluded that NTG eyes showed generalized microvascular attenuations, in which OCT-A capillary metrics attenuations were more prominent and strongly associated with NTG.
Figure S3 from Whole-Exome Sequencing of Metaplastic Breast Carcinoma Indicates Monoclonality with Associated Ductal Carcinoma Component (2023)

&lt;p&gt;Supplemental figure S3&lt;/p&gt;
Two different R gene loci co-evolved with Avr2 of Phytophthora infestans and confer distinct resistance specificities in potato (2018)

Late blight, caused by the oomycete pathogen <i>Phytophthora infestans,</i> is the most devastating disease in potato. For sustainable management of this economically important disease, resistance breeding relies on the availability of resistance (<i>R</i>) genes. Such <i>R</i> genes against <i>P. infestans</i> have evolved in wild tuber-bearing <i>Solanum</i> species from North, Central and South America, upon co-evolution with cognate avirulence (<i>Avr</i>) genes. Here, we report how effectoromics screens with <i>Avr2</i> of <i>P. infestans</i> revealed defense responses in diverse <i>Solanum</i> species that are native to Mexico and Peru. We found that the response to AVR2 in the Mexican <i>Solanum</i> species is mediated by <i>R</i> genes of the <i>R2</i> family that resides on a major late blight locus on chromosome IV. In contrast, the response to AVR2 in Peruvian <i>Solanum</i> species is mediated by <i>Rpi-mcq1,</i> which resides on chromosome IX and does not belong to the <i>R2</i> family. The data indicate that AVR2 recognition has evolved independently on two genetic loci in Mexican and Peruvian <i>Solanum</i> species, respectively. Detached leaf tests on potato cultivar 'Désirée' transformed with <i>R</i> genes from either the <i>R2</i> or the <i>Rpi-mcq1</i> locus revealed an overlapping, but distinct resistance profile to a panel of 18 diverse <i>P. infestans</i> isolates. The achieved insights in the molecular <i>R - Avr</i> gene interaction can lead to more educated exploitation of <i>R</i> genes and maximize the potential of generating more broad-spectrum, and potentially more durable control of the late blight disease in potato.
Culture-Dependent and -Independent Identification of Polyphosphate-Accumulating <i>Dechloromonas</i> spp. Predominating in a Full-Scale Oxidation Ditch Wastewater Treatment Plant (2016)

The oxidation ditch process is one of the most economical approaches currently used to simultaneously remove organic carbon, nitrogen, and also phosphorus (P) from wastewater. However, limited information is available on biological P removal in this process. In the present study, microorganisms contributing to P removal in a full-scale oxidation ditch reactor were investigated using culture-dependent and -independent approaches. A microbial community analysis based on 16S rRNA gene sequencing revealed that a phylotype closely related to Dechloromonas spp. in the family Rhodocyclaceae dominated in the oxidation ditch reactor. This dominant Dechloromonas sp. was successfully isolated and subjected to fluorescent staining for polyphosphate, followed by microscopic observations and a spectrofluorometric analysis, which clearly demonstrated that the Dechloromonas isolate exhibited a strong ability to accumulate polyphosphate within its cells. These results indicate the potential key role of Dechloromonas spp. in efficient P removal in the oxidation ditch wastewater treatment process.
Photoelectron spectroscopy of AlnS1− clusters (n=1−9) (1995)

Photoelectron spectra of AlnS−1 (1≤n≤9) cluster anions were measured at the photon energies of 3.49 and 4.66 eV, using a magnetic bottle electron spectrometer having ∼60 meV resolution. AlS− has an electron affinity of as large as 2.6 eV, attributed to large stability by six bonding electrons. A new electronic state, A′ 2Π, was found 0.4 eV above the AlS ground state, which is in agreement with theoretical calculations. AlnS−1 cluster anions are produced efficiently up to n=5, but the production of larger cluster sizes is found difficult. The mass distribution of AlnS−1 cluster anions and electron binding energy can be explained by a geometric structure obtained by theoretical calculation.
Low-frequency limitations in saturated and delayed networked control (2015)

The paper analyzes a continuous time nonlinear networked control system where delay and saturation are main effects. These effects occur e.g. in control of flow of a general quantity from a source node to a sink node. The flow is one-directional, meaning that there is a saturation between the nodes that limits the flow to be positive and below a maximum value. The controlled plant is located in the sink node and the controller is located in the source node. The plant and the controller are modeled by linear filters parameterized with poles and zeros. Feed-forward control from a measured disturbance is included. Delays affect both the downlink control signal and the uplink measurement signals. The paper proves that for large delays, L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> -stability does not follow from the Popov criterion unless the quotient of the products of all zeros and the product of all poles in the feedback path is less than 1/kG <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">p</sub> , where k is the slope of the saturation and G <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">p</sub> is the gain constant of the loop gain. In case the plant models a leaky reservoir, the conclusion is that the amount of low frequency gain of the controller cannot be arbitrarily high at the same time as the amount of leakage of the reservoir is arbitrarily low. For data flow control in communications this means that an increased requirement to regulate static errors of the data queue needs to be accompanied by a reduced capacity.
Structures and Functions of Four Anabolic 2‐Oxoacid Oxidoreductases in Methanobacterium Thermoautotrophicum (1997)

Methanobacterium thermoautotrophicum (strain Marburg), which grows autotrophically on H2 and CO2, was found to contain 2-oxoisovalerate oxidoreductase (Vor) and indolepyruvate oxidoreductase (Ior) besides pyruvate oxidoreductase (Por) and 2-oxoglutarate oxidoreductase (Kor). So far, Vor and Ior have only been detected in peptide-utilizing hyperthermophilic Archaea. The four 2-oxoacid oxidoreductases were purified and characterized with respect to their subunit composition, N-terminal amino acid sequences, and catalytic properties. Por and Kor were composed of four different subunits, Vor was composed of three different subunits, and Ior of two different subunits. Comparisons of the N-terminal amino acid sequences revealed that the four enzymes are structurally related to each other and to the respective enzymes from Pyrococcus and Thermococcus sp. Vor from M. thermoautotrophicum differed from Vor from Pyrococcus furiosus in being composed of only three instead of four different subunits. Evidence is presented that in the autotrophic methanogen the four 2-oxoacid oxidoreductases have anabolic functions, Vor and Ior being involved in the biosynthesis of amino acids from fatty acids taken up from the growth medium, as shown by 14C-labelling studies.
Dynamic Channel Model With Overhead Line Poles for High-Speed Railway Communications (2018)

In order to develop reliable communication links for high-speed railway (HSR) systems, accurate models for the propagation channel are required. The radio channel properties in HSR scenarios are different from those in cellular scenarios not only due to the high velocity, but also due to the special construction elements and the type of surroundings along the train lines. This letter focuses on the influence of overhead line poles along the railway on the HSR communication channel. The overhead line poles affect the line-of-sight communication path periodically, and also act as static and periodic scatterers along railway lines. We performed a measurement campaign at a carrier frequency of 2.4 GHz on the Guangzhou-Shenzhen dedicated high-speed train line in China. Based on the measurement result we propose a dynamic channel model considering periodic poles for HSR communication.
Real-Time Grasp Planning for Multi-Fingered Hands by Finger Splitting (2018)

Grasp planning for multi-fingered hands is computationally expensive due to the joint-contact coupling, surface nonlinearities and high dimensionality, thus is generally not affordable for real-time implementations. Traditional planning methods by optimization, sampling or learning work well in planning for parallel grippers but remain challenging for multi-fingered hands. This paper proposes a strategy called finger splitting, to plan precision grasps for multi-fingered hands starting from optimal parallel grasps. The finger splitting is optimized by a dual-stage iterative optimization including a contact point optimization (CPO) and a palm pose optimization (PPO), to gradually split fingers and adjust both the contact points and the palm pose. The dual-stage optimization is able to consider both the object grasp quality and hand manipulability, address the nonlinearities and coupling, and achieve efficient convergence within one second. Simulation results demonstrate the effectiveness of the proposed approach. The simulation video is available at: http://me.berkeley.edu/\%7Eyongxiangfan/IROS2018/fingersplit.html
Using Heart Rate and Accelerometry to Define Quantity and Intensity of Physical Activity in Older Adults (2018)

These findings suggest that time spent in moderate or higher intensity activities may not be lower with age after considering changes in physiology, functional ability, and subclinical disease burden and highlight the need for more age- and ability-specific PA research to inform future interventions and public health guidelines.
Supplementary Figure 1 from Brain Tumor Cells in Circulation Are Enriched for Mesenchymal Gene Expression (2023)

&lt;p&gt;GBM8 and GBM24 growth in culture.&lt;/p&gt;
Phenotypic Analysis of Arrhythmogenic Cardiomyopathy in the Hutterite Population: Role of Electrocardiogram in Identifying High‐Risk Desmocollin‐2 Carriers (2014)

The ECG reliably identifies homozygous p.Gln554X carriers and may be useful as an initial step in the screening of high-risk Hutterites. The cardiac phenotype of heterozygotes appears benign, but further prospective follow-up of their arrhythmic risk is needed.
Early Loss of Splenic Tfh Cells in SIV-Infected Rhesus Macaques (2015)

Follicular T helper cells (Tfh), a subset of CD4 T lymphocytes, provide crucial help to B cells in the production of antigen-specific antibodies. Although several studies have analyzed the dynamics of Tfh cells in peripheral blood and lymph nodes (LNs) during Aids, none has yet addressed the impact of SIV infection on the dynamics of Tfh cells in the spleen, the primary organ of B cell activation. We show here a significant decrease in splenic Tfh cells in SIVmac251-infected rhesus macaques (RMs) during the acute phase of infection, which persists thereafter. This profound loss is associated with lack of sustained expression of the Tfh-defining transcription factors, Bcl-6 and c-Maf but with higher expression of the repressors KLF2 and Foxo1. In this context of Tfh abortive differentiation and loss, we found decreased percentages of memory B cell subsets and lower titers of SIV-specific IgG. We further demonstrate a drastic remodeling of the lymphoid architecture of the spleen and LNs, which disrupts the crucial cell-cell interactions necessary to maintain memory B cells and Tfh cells. Finally, our data demonstrated the early infection of Tfh cells. Paradoxically, the frequencies of SIV DNA were higher in splenic Tfh cells of RMs progressing more slowly suggesting sanctuaries for SIV in the spleen. Our findings provide important information regarding the impact of HIV/SIV infection on Tfh cells, and provide new clues for future vaccine strategies.
Analytical prediction of spectral regrowth and correlated and uncorrelated distortion in multicarrier wireless transmitters exhibiting memory effects (2010)

Measurement of non-linearity effects in wireless transmitters had been always difficult under complex digitally modulated signals. On the other hand, blind time domain simulation of these effects is generally time consuming and insufficient. In this study, the authors present new frequency domain closed-form formulas for predicting the spectral regrowth in wireless communication systems/subsystems with fifth-order non-linearity exhibiting memory effects. Particularly, the suggested formulas estimate the power spectral density, as well as the undesirable adjacent-channel and co-channel emissions of the modelled device, under phase-aligned and randomly phase-modulated multitone excitations. In addition, they are able to predict the correlated and uncorrelated distortion powers separately. The efficiency and robustness of the proposed approach has been demonstrated by predicting the output of a laterally diffused metal oxide semiconductor Doherty-based power amplifier. The obtained results have been compared to measurements and those of time-domain simulators and have revealed good accuracy and time efficiency.
The Future of Satellite TV: The Wide Range of Applications of the DVB-S2 Standard and Perspectives (2011)

The first two generations of TV broadcasting are almost history, at least from the standardization perspective. Analog and digital satellite distributions both have addressed mass markets. The next-generation TV systems are close to primetime deployments: HDTV, 3DTV, interactive services, hybrid services, and additional innovations will dominate the next-generation TV. With the efficiency and maturity of DVB-S2, satellite distribution is a cost-efficient and well-established broadcast technology with significant potential for extensions. In this paper, the future perspectives of digital TV and HDTV broadcasting will be first explored, considering ongoing and future standardization activities that will be carried out. Particular attention to innovative solutions based on adaptive modulation and coding, source and channel coding, and error resilience techniques for satellite TV transmission is paid. In addition to broadcast TV, also the perspectives of hybrid and IPTV will be considered in a satellite scenario with their pros and cons, trying to understand if satellite IPTV will be in competition with “conventional” broadcast satellite TV services (like it already happens in terrestrial scenarios).
A quantitative approach to development and validation of synthetic benchmarks for behavioral synthesis (1998)

We present a quantitative approach to development and v~ldation of synthetic benchmarks for behavioral synth=is systems. me approach is built on the idea of qwntitative benchrk selection. We briefly explain the idea and pr~ent experimental results on the quantitative selection and vfidation of benchmarks. We develop a synthetic design example generator which composes the behavioral level specification of a d~ign having the propertiw given by a set of numencd parameters. Experimental generation and application of synthetic design examples demonstrate the effwtiveness of the proposal approach and the develo@ algorithms.
Small molecule mimetics of GHRP-6 (1997)

In 1981, Bowers reported that xenobiotic peptides, derived from the Leu- and Met- enkephalins, demonstrated novel growth hormone (GH) secretory activity. The most potent peptide reported, GH releasing peptide-6 (GHRP-6), was shown to release GH by a different pathway to the known signalling peptide, growth hormone releasing hormone (GHRH). The discovery of a peptidyl GH secretagogue laid the foundation for the search for smaller, orally active mimetics of GHRP-6, as well as for its mechanism of action. This review focuses on the recent developments in the field of small molecule GH secretagogues from a medicinal chemistry perspective, and discusses various structural classes of mimetics recently reported in the literature.
Using New 3D CLEM Imaging Technique to Investigate the Effects of Substrate Mechanics on Cellular Uptake of Nanoparticle (2017)

Journal Article Using New 3D CLEM Imaging Technique to Investigate the Effects of Substrate Mechanics on Cellular Uptake of Nanoparticle Get access Ya-Chen Chuang, Ya-Chen Chuang Department of Materials Science and Engineering, Stony Brook University, Stony Brook, NY 11794, USAThINC Facility, Advanced Energy Center, Stony Brook University, Stony Brook, NY 11794, USA Search for other works by this author on: Oxford Academic Google Scholar Wan-Yi Yen, Wan-Yi Yen Stem Cell Facility, Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA Search for other works by this author on: Oxford Academic Google Scholar Linxi Zhang, Linxi Zhang Department of Materials Science and Engineering, Stony Brook University, Stony Brook, NY 11794, USAThINC Facility, Advanced Energy Center, Stony Brook University, Stony Brook, NY 11794, USA Search for other works by this author on: Oxford Academic Google Scholar Wadie Bahou, Wadie Bahou Stem Cell Facility, Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA Search for other works by this author on: Oxford Academic Google Scholar Marcia Simon, Marcia Simon Department of Oral Biology and Pathology, Stony Brook University, Stony Brook, NY 11794, USA Search for other works by this author on: Oxford Academic Google Scholar Miriam Rafailovich, Miriam Rafailovich Department of Materials Science and Engineering, Stony Brook University, Stony Brook, NY 11794, USA Search for other works by this author on: Oxford Academic Google Scholar Chung-Chueh Chang Chung-Chueh Chang ThINC Facility, Advanced Energy Center, Stony Brook University, Stony Brook, NY 11794, USA Search for other works by this author on: Oxford Academic Google Scholar Microscopy and Microanalysis, Volume 23, Issue S1, 1 July 2017, Pages 1302–1303, https://doi.org/10.1017/S1431927617007176 Published: 04 August 2017
115. Tumor Microenvironment-Targeting Hybrid Vector System Utilizing Oncolytic Adenovirus Complexed with pH-Sensitive and Bioreducible Polymer (2016)

Oncolytic adenoviruses (Ads) have shown great promise in cancer gene therapy but their efficacy has been compromised by potent immunological, biochemical, and specific tumor-targeting limitations. To take full advantage of the innate cancer-specific killing potency of oncolytic Ads but also exploit the subtleties of the tumor microenvironment, we have generated a pH-sensitive and bio-reducible polymer (PPCBA)-coated oncolytic Ad. Ad-PPCBA complexes showed higher cellular uptake at pH 6.0 than pH 7.4 in both high and low coxsackie and adenovirus receptor-(CAR)-expressing cells, thereby demonstrating Ad-PPCBA's ability to target the low pH hypoxic tumor microenvironment and overcome CAR dependence for target cell uptake. Endocytic mechanism studies indicated that Ad-PPCBA internalization is mediated by macropinocytosis instead of the CAR-dependent endocytic pathway that internalizes naked Ad. VEGF-specific shRNA-expressing oncolytic Ad complexed with PPCBA (RdB/shVEGF-PPCBA) elicited much more potent suppression of U87 human brain cancer cell VEGF gene expression in vitro, and human breast cancer MCF7 cell/Matrigel plug vascularization in a mouse model, when cancer cells had been previously infected at pH 6.0 versus pH 7.4. Moreover, intratumorally and intravenously injected RdB/shVEGF-PPCBA nanocomplexes elicited significantly higher therapeutic efficacy than naked virus in U87-tumor mouse xenograft models, reducing IL-6, ALT, and AST serum levels. These data demonstrated PPCBA's biocompatibility and capability to shield the Ad surface to prevent innate immune response against Ad after both intratumoral and systemic administration. Taken together, these results demonstrate that smart, tumor-specific, oncolytic Ad-PPCBA complexes can be exploited to treat both primary and metastatic tumors.
Femto-Macro Cellular Interference Control with Subband Scheduling and\n Interference Cancelation (2010)

A significant technical challenge in deploying femtocells is controlling the\ninterference from the underlay of femtos onto the overlay of macros. This paper\npresents a novel interference control method where the macrocell bandwidth is\npartitioned into subbands, and the short-range femtocell links adaptively\nallocate their power across the subbands based on a load-spillage power control\nmethod. The scheme can improve rate distribution in the macro network while\nalso providing opportunities for short-range communication as well. Moreover,\nthe proposed scheme requires minimal interference coordination communication\nbetween the femtos and macros, which is one of the main challenges in femtocell\nsystems. Also, simulations show certain advantages over simpler\northogonalization schemes or power control schemes without subband\npartitioning. Further modest gains may also be possible with interference\ncancelation.\n
ChemInform Abstract: Synthesis of Some 13‐Oxaprostanoids. (1990)

Abstract Key step in the new preparation of 13‐oxaprostaglandins, biologically interesting compounds, is the reaction of Dps‐Cl (II) with an encumbered secondary hydroxy group in the presence of an adjacent hindered secondary hydroxy group to give the synthon (V).