gebhart/patrepeval huggingface dataset:
A prothrombogenic phenotype is exhibited in sickle cell transgenic mice (2008)

Sickle cell disease (SCD) is a chronic genetic and lifelong disease, affecting the vasculature of different organs (1). This study, investigated the effects of SCD on thrombus formation. Intravital microscopy was performed in the cerebral microcirculation of wild‐type (WT), sickle cell transgenic (SCD; ƒÒs) and WT/ƒÒs chimeric (positive control) mice (as previously described: 1). Thrombus formation was formed using the light/dye model in arterioles and venules. Flow cessation time was recorded. Thrombus formation was reduced by 50% in SCD mice vs. WT in venules and arterioles. However, no difference was seen in WT/ƒÒs chimeric mice, suggesting the SCD mice response was not due to how they were generated. The clinical implication of anti‐coagulant therapy in SCD mice was investigated. Both Hirudin and anti‐thrombin III were administered. Although Hirudin increased the time required for thrombus formation, the anti‐thrombin III inhibitor was more effective in SCD venules, suggesting thrombus formation is effected via thrombin, but is dependent upon the anti‐thrombin III pathway in venules. These data further support the growing evidence for a pro‐inflammatory and pro‐thrombogenic microcirculation in SCD mice, which may lead to the identification of potential therapeutic targets in this painful and life‐threatening disease. Supported by the BBSRC
Synthesis of WO3 Nanorods by Reacting WO(OMe)4 under Autogenic Pressure at Elevated Temperature Followed by Annealing. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Systematic integrative analysis of gene expression identifies HNF4A as the central gene in pathogenesis of non-alcoholic steatohepatitis (2017)

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the Western world, and encompasses a spectrum from simple steatosis to steatohepatitis (NASH). There is currently no approved pharmacologic therapy against NASH, partly due to an incomplete understanding of its molecular basis. The goal of this study was to determine the key differentially expressed genes (DEGs), as well as those genes and pathways central to its pathogenesis. We performed an integrative computational analysis of publicly available gene expression data in NASH from GEO (GSE17470, GSE24807, GSE37031, GSE89632). The DEGs were identified using GEOquery, and only the genes present in at least three of the studies, to a total of 190 DEGs, were considered for further analyses. The pathways, networks, molecular interactions, functional analyses were generated through the use of Ingenuity Pathway Analysis (IPA). For selected networks, we computed the centrality using igraph package in R. Among the statistically significant predicted networks (p-val < 0.05), three were of most biological interest: the first is involved in antimicrobial response, inflammatory response and immunological disease, the second in cancer, organismal injury and development and the third in metabolic diseases. We discovered that HNF4A is the central gene in the network of NASH connected to metabolic diseases and that it regulates HNF1A, an additional transcription regulator also involved in lipid metabolism. Therefore, we show, for the first time to our knowledge, that HNF4A is central to the pathogenesis of NASH. This adds to previous literature demonstrating that HNF4A regulates the transcription of genes involved in the progression of NAFLD, and that HNF4A genetic variants play a potential role in NASH progression.
Tumoral BRD4 expression in lymph node-negative breast cancer: association with T-bet+ tumor-infiltrating lymphocytes and disease-free survival (2018)

The association of BRD4 expression with T-bet+ TILs, and T-bet+ TIL-dependent disease-free survival suggests a potential link between BRD4-mediated tumor development and tumor immune surveillance, possibly through BRD4's regulation of Jagged1 signaling pathways. Further understanding BRD4's role in different immune contexts may help to identify an appropriate subset of breast cancer patients who may benefit from BET inhibitors without the risk of diminishing the anti-tumoral immune activity.
Frequency comb referenced displacement interferometry for the NIST calculable capacitor (2012)

This paper describes the ongoing work on measuring the variable spacing between two electrodes in the next-generation NIST calculable capacitor. The spacing measurement is based on a high finesse Fabry-Perot interferometer system where displacements are inferred from optical frequency measurements. Using a frequency comb referenced to an atomic clock as an optical frequency standard, we achieve a fractional uncertainty of δν/ν ~ 2·10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-11</sup> at 2 seconds. This corresponds to a stabilization of the spacing at the picometer level.
Cutting the Gordian Helix — Regulating Genomic Testing in the Era of Precision Medicine (2015)

The new Precision Medicine Initiative will require advances in our regulatory frameworks, especially for genomic testing. The FDA has been exploring radical new approaches, aiming to promote rapid innovation while ensuring safety and efficacy.
Faldaprevir combined with peginterferon alfa-2a and ribavirin in chronic hepatitis C virus genotype-1 patients with prior nonresponse: SILEN-C2 trial (2013)

Faldaprevir 240 mg QD with PegIFN/RBV was safe and tolerable and produced substantial SVR rates in prior null and partial responders. The 240 mg QD dose is currently undergoing phase 3 evaluation.
Effect of Resistive Invasion on Resistivity Logs (2001)

Abstract One of the more difficult decisions facing the petrophysicist is deciding which resistivity tool to use. Induction tools are best suited for low-resistivity formations drilled with fresh or nonconductive mud. Laterolog or resistivity tools are best in the opposite conditions. An important effect to consider when choosing the tool is the contrast of flushed zone resistivity (Rxo) to true formation resistivity (Rt). Laterolog tools have a difficult time estimating true formation resistivity when Rxo is greater than Rt. This effect, though well known, still seems to catch petrophysicists by surprise and can cause serious errors in the formation analysis. In this paper we demonstrate the potential problems by examining three case studies where both induction and laterolog tools were run. Comparing measured tool response to forward modeling results helps explain the measurements. The first case study could be considered a classic case of resistive invasion. The mud resistivity was 0.78 ohm-m at bottom hole temperature. In a wet sand, the deep laterolog resistivity measurement is affected by the higher flushed zone resistivity and consequently reads much higher than the deep induction measurement. The resistive invasion is clearly seen on either the laterolog resistivity or induction measurements and can therefore be detected, although it is easier to estimate Rt with the induction. Resistive invasion effects are much more difficult to see on our second case study. A fractured carbonate with high formation resistivity of around 100 ohm-m was drilled with fresh mud. The fresh mud invasion in a wet zone results in Rxo greater than Rt, and the deep laterolog resistivity was consequently higher than the deep induction by almost one decade. However, the natural fractures resulted in the deep laterolog resistivity reading being greater than the shallow resistivity, which is typical of pay zones, and made detection of the shallow resistive invasion difficult using only a deep and shallow laterolog resistivity. Forward modeling suggests that the deep induction provides the best estimate of Rt in wet zones, while the deep laterolog resistivity measurement is best in hydrocarbon intervals. The final case study demonstrates this effect on a laterolog resistivity measurement made while drilling. The measurement was to be used to stop drilling at the top of a water leg. Unfortunately, the fresh mud filtrate and rapid mud spurt losses resulted in a flushed zone resistivity higher than formation resistivity in the water leg. Comparison between the laterolog bit resistivity (earliest measurement on the tool) and later measurements provided an indication of the effect. However, the difference is subtle and difficult to see on the field logs. Comparisons with the induction data clearly demonstrate the effects of resistive invasion on laterolog measurement in this environment.
SEARCHES FOR HIGH-FREQUENCY VARIATIONS IN THE8B SOLAR NEUTRINO FLUX AT THE SUDBURY NEUTRINO OBSERVATORY (2010)

We have performed three searches for high-frequency signals in the solar neutrino flux measured by the Sudbury Neutrino Observatory, motivated by the possibility that solar g-mode oscillations could affect the production or propagation of solar 8B neutrinos. The first search looked for any significant peak in the frequency range 1-144day-1, with a sensitivity to sinusoidal signals with amplitudes of 12% or greater. The second search focused on regions in which g-mode signals have been claimed by experiments aboard the Solar and Heliospheric Observatory satellite, and was sensitive to signals with amplitudes of 10% or greater. The third search looked for extra power across the entire frequency band. No statistically significant signal was detected in any of the three searches. © 2010. The American Astronomical Society.
Delayed aortic rupture after radiochemotherapy and esophagectomy for esophageal cancer (2003)

Spontaneous rupture of major vessels is a known though rare complication in treatment of patients with esophageal cancer, but its pathophysiology is not very well understood. We herein report about the sudden death of a 42-year-old man due to spontaneous aortic rupture, 11 days after transthoracic esophagectomy. Because of a locally advanced squamous cell carcinoma of the distal esophagus, which was considered irresectable at the time of presentation, the patient had received one course of chemotherapy followed by synchronous chemoradiation (60 Gy, 5-fluorouracil and cisplatin) prior to surgery. We discuss the patho-anatomic findings of the postmortem examination concerning alterations of the aortic wall and the potential correlations with aggressive radiochemotherapy protocols.
Intermodal injection locking and gain profile measurement of GaAlAs lasers (1984)

Injection locking of a GaAlAs laser by coupling light into a nonlasing Fabry-Perot mode separated by up to 22 mode spacings (60 Å) from the free-running lasing mode is demonstrated. The gain spectra for operation above threshold are determined from measurements of the wavelength dependence of the injected power required for locking. These results are compared to gain curves deduced from spontaneous emission spectra measured slightly below threshold. For the greatest wavelength separation, the gain difference was found to be about 4 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> , with injected power levels of 1 percent of the total slave laser power required to obtain 75 percent of the total energy at the master laser frequency.
Amplification of chirality in benzene tricarboxamide helical supramolecular polymers (2006)

The chirality of benzene tricarboxamides is expressed and amplified into the helicity of self-assembled columnar aggregates according to 'sergeants and soldiers' and 'majority rules' principles; the strength of the amplification is analysed quantitatively and the effect of the number of chiral groups in the sergeants is studied.
LOCAL ELECTRONIC PROPERTIES OF DOMAIN BOUNDARIES ON c(2 × 2) Fe(001) THIN FILM SURFACES (2006)

Scanning tunneling microscopy (STM) and spectroscopy have been performed on a nanostructure "line-like pattern" appearing on atomically flat terraces of bcc-Fe (001) with a c(2 × 2) reconstructed structure. Atomically resolved STM reveals that the line-like pattern consists of regularly aligned surface atoms that have a similar symmetry to the (1 × 1) structure of Fe (001). The line-like pattern plays a role of domain boundaries of c(2 × 2) domains. The patterns exhibit bias-voltage dependent image contrast in the STM topographic images. In negative sample bias-voltage range the patterns appear lower than the c(2 × 2) domains and higher in positive range. In dI/dV tunneling spectra taken on the patterns a shoulder is observed around +0.2 V. On the other hands, a small salient is distinguished around +0.4 V in the spectra taken on the c(2 × 2) domains. These features are originated from surface states existing on bcc-Fe (001) surfaces with (1 × 1) structure and c(2 × 2) reconstructed structure, respectively. Emergence of the line-like patterns results in the difference of tunneling conductance.
Absorption of Valproic Acid Suppositories in Human Volunteers (1989)

The absorption of valproic acid administered by rectal suppository was studied in six male volunteers. Valproic acid was incorporated into a synthetic lipid base in our pharmacy. Each subject received 500 mg of valproic acid by rectal suppository and 500 mg of oral valproate sodium syrup one week apart; 13 blood samples were drawn to determine serum concentrations over 48 hours after administration of each formulation. Significant differences were evident in the amount absorbed, maximum serum concentration, and time to achieve maximum serum concentration between the oral and rectal formulations. Mean absorption after rectal suppository was 80%. Maximum serum concentration was 43.4 mg/L after oral administration and 29.2 mg/L after rectal suppository. The time to achieve maximum serum concentration was 1.0 hour after oral syrup and 3.1 hours after rectal suppository. Absorption of the rectal suppository was consistent and complete within 3 hours. The use of valproate sodium in rectal suppository form can be a more convenient and satisfactory method of administering valproic acid when the oral route is impossible. Dosage increases may be necessary, and serum concentrations should be monitored.
Techniques for System Information Broadcast in Cell-Free Massive MIMO (2018)

We consider transmission of system information in a cell-free massive MIMO system, when the transmitting access points do not have any channel state information and the receiving terminal has to estimate the channel based on downlink pilots. We analyze the system performance in terms of outage rate and coverage probability and use space-time block codes to increase performance. We propose a heuristic method for pilot/data power optimization that can be applied without any channel state information at the access points. We also analyze the problem of grouping the access points, which is needed when the single-antenna access points jointly transmit a space-time block code.
3D in vivo brain elasticity mapping in small animals using ultrasound (2009)

Supersonic Shear Imaging (SSI) is an ultrasound based technique for elasticity imaging that has been successfully tested on several organs in the framework of cancer diagnosis. In this work, the potential of this technique to map brain elasticity in vivo on trepanned small animals is investigated. From a SSI scan in the sagittal plane of the brain, a 3D elasticity map is reconstructed. A good correlation between the elasticity map and anatomy is observed. The values of dynamic modulus lie between 1 and 16 kPa and grey matter appears softer than white matter. The propagation of shear waves is found to be anisotropic in the cortex, which could be a consequence of the fiber orientation. Moreover, the good temporal resolution of this technique allows a dynamic estimation of brain elasticity within one single cardiac cycle. In the cortex, it is shown that the passage of the arterial pulse do not transiently modify elasticity. Next experiments will focus on applying this new technique in small animal models of neurological pathologies to estimate the effect of damaged tissues on elasticity.
Analysis and evaluation of harmonic suppression of lumped-element networks suitable for high-frequency class-E operation condition approximation (2008)

The harmonic output of microwave lumped-element class-E load-coupling topologies is assessed. Measurement results on fabricated C-band class-E power amplifiers with either a modified lowpass and an optimised second-harmonic impedance network show that the latter provides better performance not only in terms of output power, gain and efficiency, but also in regard to harmonic suppression. Compared with the common modified lowpass network, harmonic content in the load of the optimised second-harmonic impedance topology at the second-, third- and fourth-harmonic frequencies are lower by more than 5.8, 10 and 5.8 dB, respectively.
Broadband undersampled synthetic aperture arrays: Targets stay sharp, aliases smear (1990)

Synthetic aperture sonars (SAS) or radars (SAR) that transmit narrow-band signals are sampled arrays and therefore must satisfy sampling requirements to avoid aliasing. The sampling requirements for a narrow-band SAS or SAR may be relaxed if a broadband signal is used. From a beamforming view, broadband transmit signals result in a mainlobe that always points in the same direction and has a width that varies as the transmit signal sweeps through the broadband, but having aliasing lobes that change in both width and direction. A composite broadband beam pattern would show constructive mainlobes but smeared aliasing lobes. Broadband undersampled synthetic aperture images similarly show a target image having the same x–y image space position for all frequencies, but alias target images that have azimuth positions that vary with frequency. A synthetic aperture image uses the entire transmit band, and so, targets appear sharp and aliases become smeared. An approximate relation for the level of smearing of the alias targets may be shown, which depends on the signal bandwidth, the platform speed, the sonar along-track length, center frequency, and the pulse rate. This allows the design of broadband undersampled synthetic aperture sonars with higher speeds and greater mapping rates. [Work supported by the Charles Stark Draper Laboratory, Cambridge, MA.]
Surface-Functionalized Particles: From their Design and Synthesis to Materials Science and Bio-Applications (2013)

The purpose of this highlight is to demonstrate the importance of the surface functionalization of nanoparticles toward the design of high-tech (nano)materials. These (nano)materials are “nano-tools” for the already established interdisciplinary research fields of nanoscience and nanotechnology, which find an enormous variety of applications in different areas. In many cases, the particle-forming material, shape, and size determine the applicability of the desired nanoparticle. Nevertheless, in most of the cases other parameters must also be accurately adjusted to transform those nano-objects into functional nanoparticles, such as dispersibility, stability, reactivity, ability to recognize (or to be recognized by) other systems, and the interaction between these parameters and a matrix or dispersing medium. Most of these parameters are mainly depending on the surface characteristics of the nanoparticles. Thus, this highlight focuses not only on the importance of the surface functionalization of the nanoparticles to render them applicable, but also on the different strategies to design and obtain surface-functionalized nanoparticles (SF-NPs) and on their successful exploitation in materials science, formulation of organic–inorganic hybrid nanostructures and bio-applications. Keywords: Surface-Functionalized Nanoparticles, Surfmer, Self-healing, Miniemulsion, Bio-application, Stimuli Responsive Materials.
Cycloheximide sensitivity in regulation of acyl coenzyme A:cholesterol acyltransferase activity in Chinese hamster ovary cells. 2. Effect of sterol endogenously synthesized (1986)

We reported in another paper [Chang, C. C. Y., Doolittle, G. M., & Chang, T. Y. (1986) Biochemistry (preceding paper in this issue)] that in Chinese hamster ovary (CHO) cells activation of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity by treating cells with cycloheximide was abolished by providing exogenous sterol in the medium. We now report that providing 20 mM DL-mevalonate to cells grown in sterol-free medium increases the ACAT activity by approximately 6-fold and diminishes the cycloheximide activation effect. The mevalonate supplement has no significant effect on the rate of triglyceride or polar lipid synthesis, [3H]cholesterol efflux, or bulk protein degradation in cells. The activation of ACAT by mevalonate is prevented by adding a specific squalene oxide cyclase inhibitor to cells, indicating the requirement for endogenous sterol synthesis to mediate the mevalonate effect. In sterol-free medium, if sterol synthesis is blocked by specific enzyme inhibitors or through mutation, the ACAT activation by cycloheximide is again abolished. These results support the hypothesis that there may exist a short-lived factor(s) serving directly or indirectly as an endogenous ACAT inhibitor(s), the inhibitory action of this (these) factor(s) is (are) abolished, and its (their) turnover rate(s) is (are) increased by either exogenous sterol or by sterol endogenously synthesized. Conversely, removing exogenous sterol coupled with blocking endogenous sterol synthesis decreases the turnover rate(s) of the inhibitor(s), rendering its (their) action insensitive to intracellular degradation over the time period studied.
Ultra wideband tapered slot antenna with band-stop characteristic (2004)

This paper proposes a novel ultra wideband (UWB) tapered slot antenna (TSA) to achieve both enhanced impedance bandwidth for UWB RF front-ends and band-stop characteristics in the 5 GHz WLAN band, limited by IEEE802.11a and HIPERLAN/2. To obtain these two characteristics of wideband and band-stop in the TSA, a broadband microstrip-slotline transition with multi-arm stubs and /spl lambda//4 short stubs are used respectively. From the measured results, it can be shown that a wide bandwidth of 1.99 octaves from 2.8 to 11.09 GHz for a VSWR<2 is obtained while the 5.0 /spl sim/5.93 GHz band is rejected.
Correction to Nonlinear Microfluidics (2019)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to Nonlinear MicrofluidicsDaniel StoeckleinDaniel StoeckleinMore by Daniel Stoecklein and Dino Di Carlo*Dino Di CarloMore by Dino Di CarloCite this: Anal. Chem. 2019, 91, 19, 12596Publication Date (Web):September 10, 2019Publication History Published online10 September 2019Published inissue 1 October 2019https://pubs.acs.org/doi/10.1021/acs.analchem.9b03985https://doi.org/10.1021/acs.analchem.9b03985correctionACS PublicationsCopyright © 2019 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views1206Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (171 KB) Get e-Alertsclose Get e-Alerts