gebhart/patrepeval huggingface dataset:
Hemodynamics of Stent Implantation Procedures in Coronary Bifurcations: an in vitro study (2016)

Stent implantation in coronary bifurcations presents unique challenges and currently there is no universally accepted stent deployment approach. Despite clinical and computational studies, to date, the effect of each stent implantation method on the coronary artery hemodynamics is not well understood. In this study the hemodynamics of stented coronary bifurcations under pulsatile flow conditions were investigated experimentally. Three implantation methods, provisional side branch (PSB), culotte (CUL), and crush (CRU), were investigated using time-resolved particle image velocimetry (PIV) to measure the velocity fields. Subsequently, hemodynamic parameters including wall shear stress (WSS), oscillatory shear index (OSI), and relative residence time (RRT) were calculated and the pressure field through the vessel was non-invasively quantified. The effects of each stented case were evaluated and compared against an un-stented case. CRU provided the lowest compliance mismatch, but demonstrated detrimental stent interactions. PSB, the clinically preferred method, and CUL maintained many normal flow conditions. However, PSB provided about a 300% increase in both OSI and RRT. CUL yielded a 10% and 85% increase in OSI and RRT, respectively. The results of this study support the concept that different bifurcation stenting techniques result in hemodynamic environments that deviate from that of un-stented bifurcations, to varying degrees.
Exploiting Polarization for Spectrum Sensing in Cognitive SatComs (2012)

Exploring new techniques for spectrum sensing (SS), which can detect the weak primary signals instantly, has been an important research challenge. In this paper, the problem of enhancing SS efficiency in cognitive SatComs has been considered. The analysis of different combining techniques has been c
Intracluster Atomic and Electronic Structural Heterogeneities in Supported Nanoscale Metal Catalysts (2015)

This work reveals and quantifies the inherent intracluster heterogeneity in the atomic structure and charge distribution present in supported metal catalysts. The results demonstrate that these distributions are pronounced and strongly coupled to both structural and dynamic perturbations. They also serve to clarify the nature of the dynamic bonding of nanoscale catalytic metal clusters with their supports, and the mediation of these properties due to the presence of adsorbates. These findings are supported by theoretical modeling and experimental data measured for an exemplary supported metal catalyst, Pt supported on silica, using in situ high energy resolution X-ray absorption and emission spectroscopies; in situ diffuse reflectance infrared Fourier transform spectroscopy; and ex situ scanning transmission electron microscopy.
Knee Joint Misalignment in Exoskeletons for the Lower Extremities: Effects on User's Gait (2015)

Due to the complexity of the human musculoskeletal system and intra/intersubjects variability, powered exoskeletons are prone to human-robot misalignments. These induce undesired interaction forces that may jeopardize safe operation. Uncompensated inertia of the robotic links also generates spurious interaction forces. Current design approaches to compensate for misalignments rely on the use of auxiliary passive degrees of freedom that unavoidably increase robot inertia, which potentially affects their effectiveness in reducing undesired interaction forces. Assessing the relative impact of misalignment and robot inertia on the wearer can, therefore, provide useful insights on how to improve the effectiveness of such approaches, especially in those situations where the dynamics of the movement are quasi-periodic and, therefore, predictable such as in gait. In this paper, we studied the effects of knee joint misalignments on the wearer's gait, by using a treadmill-based exoskeleton developed by our group, the ALEX II. Knee joint misalignments were purposely introduced by adjusting the mismatch between the length of the robot thigh and that of the human thigh. The amount of robot inertia reflected to the user was adjusted through control. Results evidenced that knee misalignment significantly changes human-robot interaction forces, especially at the thigh interface, and this effect can be attenuated by actively compensating for robot inertia. Misalignments caused by an excessively long robot thigh are less critical than misalignments of equal magnitude deriving from an excessively short robot thigh.
Adamantyl Ethanone Pyridyl Derivatives: Potent and Selective Inhibitors of Human 11β‐Hydroxysteroid Dehydrogenase Type 1 (2011)

Elevated levels of active glucocorticoids have been implicated in the development of several phenotypes of metabolic syndrome, such as type 2 diabetes and obesity. 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) catalyses the intracellular conversion of inactive cortisone to cortisol. Selective 11β-HSD1 inhibitors have shown beneficial effects in various conditions, including diabetes, dyslipidemia and obesity. A series of adamantyl ethanone pyridyl derivatives has been identified, providing potent and selective inhibitors of human 11β-HSD1. Lead compounds display low nanomolar inhibition against human and mouse 11β-HSD1 and are selective for this isoform, with no activity against 11β-HSD2 and 17β-HSD1. Structure-activity relationship studies reveal that an unsubstituted pyridine tethered to an adamantyl ethanone motif through an ether or sulfoxide linker provides a suitable pharmacophore for activity. The most potent inhibitors have IC₅₀ values around 34-48 nM against human 11β-HSD1, display reasonable metabolic stability in human liver microsomes, and weak inhibition of key human CYP450 enzymes.
Raw data for 'Fabrication of Ge micro-disks on free-standing SiO2 beams for monolithic light emission' (2015)

This dataset contains the raw data for the fabrication of Ge micro-disks on free-standing SiO2 beams for monolithic light emission. Summary of this dataset in the form of figures were published by IEEE, proceedings of the IEEE NANO 2015 conference, Rome, Italy. 978-1-4673-8156-7/15/$31.00 © 2015 IEEE
Ibm websphere v5.0 security: websphere handbook series (2002)

WebSphere Application Server security in detail End-to-end security design with Patterns for e-business Security integration with Tivoli Access Manager This IBM Redbook provides IT Architects, IT Specialists, application designers, application developers, application assemblers, application deployers and consultants with information necessary to design, develop and deploy secure e-business applications using WebSphere Application Server V5. Part 1, WebSphere security provides a detailed overview of WebSphere Application Server V5 Security. It starts with J2EE security, then goes into details about the modules and components of a J2EE enterprise application; it also covers programmatic security techniques. The last chapter in this part shows all the security-related administrative items in WebSphere Application Server V5. Part 2, End-to-end security offers details about end-to-end security solutions where WebSphere Application Server V5 is part of an enterprise solution. You will find an introduction to Patterns for e-business, in which security is in focus. A very important chapter in this part will discuss the integration between WebSphere Application Server V5 and Tivoli Access Manager. Finally, the Appendixes provide additional information related to chapters in the previous two parts and also describe the sample application available with the book.
A selective agonist of endothelin type B receptor, IRL 1620, stimulates cyclic GMP increase via nitric oxide formation in rat aorta. (1993)

The signal transduction pathways of endothelin (ET)-induced vasorelaxation in rat aorta were investigated. An agonist for ETB receptors, IRL 1620, induced transient increases in cytosolic Ca++ (peak at about 10 sec) and cyclic GMP (peak at about 20 sec) accompanied by transient vasorelaxation (peak at about 60 sec) in aortic strips precontracted with 100 nM norepinephrine. The cyclic GMP content was increased 3- to 6-fold from the basal level (1.6 +/- 0.2 fmol/micrograms of protein) with 1 nM to 1 microM IRL 1620. The cyclic GMP elevation was endothelium-dependent, abolished in the presence of 100 microM NG-monomethyl-L-arginine, an inhibitor of nitric oxide synthase, and recovered after the further addition of 1 mM L-arginine. An ETB receptor antagonist, IRL 1038 (3 microM), inhibited completely the cyclic GMP increase induced by 100 nM IRL 1620 (8.1 +/- 0.6 fmol/micrograms of protein) without affecting the basal level. On the other hand, an ETA receptor antagonist, 3 microM BQ-123, enhanced significantly both the basal level (3.7 +/- 0.6 fmol/micrograms of protein) and the IRL IRL 1620-induced production (12.2 +/- 0.8 fmol/micrograms of protein) of cyclic GMP. Specific binding sites for [125I]IRL 1620 were detected in rat aortic membranes with a dissociation constant of 37.0 pM and maximal binding capacity of 36.6 fmol/mg of protein, which disappeared after removing the endothelium. Unlabeled ET-1, ET-3, IRL 1620 and IRL 1038, but not BQ-123, displaced the binding of [125I]IRL 1620 with inhibitory constants of 38.5 pM, 36.6 pM, 97.8 pM and 8.9 nM, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
FTP access as a user-defined file system (1994)

Current methods of accessing services provided in the internet require users to know several interfaces. We show that integrating these services into the file naming spaces brings considerable benefits: users are able to use different services by a simple file access. This mechanism is general enough so that all applications can use the available services. Our idea is demonstrated by the implementation of a file server which handles ftp access transparently. This server was integrated into the regular file name space by using the NFS interface, thus avoiding the need to relink the kernel and ensuring portability.
Investigation of piezoresistive effect in p-channel metal–oxide–semiconductor field-effect transistors fabricated on circular silicon-on-insulator diaphragms using cost-effective minimal-fab process (2018)

P-channel metal–oxide–semiconductor field-effect transistors (PMOSFETs) with the 〈110〉 or 〈100〉 channel direction have been successfully fabricated on circular silicon-on-insulator (SOI) diaphragms using a cost-effective minimal-fab process, and their electrical characteristics have been systematically investigated before and after the SOI diaphragm formation. It was found that almost the same subthreshold slope (S-slope) and threshold voltage (Vt) are observed in the fabricated PMOSFETs before and after the SOI diaphragm formation, and they are independent of the channel direction. On the other hand, significant variations in drain current were observed in the fabricated PMOSFETs with the 〈110〉 channel direction after the SOI diaphragm formation owing to the residual mechanical stress-induced piezoresistive effect. It was also confirmed that electrical characteristics of the fabricated PMOSFETs with the 〈100〉 channel direction are almost the same before and after the SOI diaphragm formation, i.e., not sensitive to the mechanical stress. Moreover, the drain current variations at different directions of mechanical stress and current flow were systematically investigated and discussed.
Nanotechnology in Stroke: New Trails with Smaller Scales (2023)

Stroke is a leading cause of death, long-term disability, and socioeconomic costs, highlighting the urgent need for effective treatment. During acute phase, intravenous administration of recombinant tissue plasminogen activator (tPA), a thrombolytic agent, and endovascular thrombectomy (EVT), a mechanical intervention to retrieve clots, are the only FDA-approved treatments to re-establish cerebral blood flow. Due to a short therapeutic time window and high potential risk of cerebral hemorrhage, a limited number of acute stroke patients benefit from tPA treatment. EVT can be performed within an extended time window, but such intervention is performed only in patients with occlusion in a larger, anatomically more proximal vasculature and is carried out at specialty centers. Regardless of the method, in case of successful recanalization, ischemia-reperfusion injury represents an additional challenge. Further, tPA disrupts the blood-brain barrier integrity and is neurotoxic, aggravating reperfusion injury. Nanoparticle-based approaches have the potential to circumvent some of the above issues and develop a thrombolytic agent that can be administered safely beyond the time window for tPA treatment. Different attributes of nanoparticles are also being explored to develop a multifunctional thrombolytic agent that, in addition to a thrombolytic agent, can contain therapeutics such as an anti-inflammatory, antioxidant, neuro/vasoprotective, or imaging agent, i.e., a theragnostic agent. The focus of this review is to highlight these advances as they relate to cerebrovascular conditions to improve clinical outcomes in stroke patients.
Fluid shear stress inhibits vascular inflammation by decreasing thioredoxin-interacting protein in endothelial cells (2005)

Regions in the vasculature that are exposed to steady laminar blood flow are protected from atherosclerosis as compared with regions where flow is disturbed. We found that flow decreased TNF-mediated VCAM1 expression by inhibiting JNK and p38. JNK inhibition correlated with inhibition of apoptosis signal-regulating kinase 1 (ASK1), a JNK and p38 activator. Thioredoxin-interacting protein (TXNIP) is a stress-responsive protein that inhibits thioredoxin (TRX) activity. Since thioredoxin inhibits ASK1, we hypothesized that changes in TXNIP-TRX-ASK1 interactions mediate the antiinflammatory effects of flow. To explore this, we used perfused vessels and cultured ECs. Exposure of rabbit aortae or ECs to normal flow (12 dyn/cm2, 24 hours) was associated with decreased TXNIP expression and increased TRX activity compared with exposure to low flow (0.4 dyn/cm2). Normal flow inhibited TNF activation of JNK/p38 and VCAM1 expression. In cultured ECs, reduction of TXNIP expression by small interfering RNA increased TRX binding to ASK1 and inhibited TNF activation of JNK/p38 and VCAM1 expression. Conversely, overexpression of TXNIP stimulated JNK and p38. In aortae from TXNIP-deficient mice, TNF-induced VCAM1 expression was inhibited. The data suggest that TXNIP and TRX are key components of biomechanical signal transduction and establish them as potentially novel regulators of TNF signaling and inflammation in ECs.
Synthesis of D-lysine8-cyclosporine A. Further characterization of BOP-Cl in the 2-7 hexapeptide fragment synthesis (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of D-lysine8-cyclosporine A. Further characterization of BOP-Cl in the 2-7 hexapeptide fragment synthesisWilliam J. Colucci, Roger D. Tung, John A. Petri, and Daniel H. RichCite this: J. Org. Chem. 1990, 55, 9, 2895–2903Publication Date (Print):April 1, 1990Publication History Published online1 May 2002Published inissue 1 April 1990https://pubs.acs.org/doi/10.1021/jo00296a061https://doi.org/10.1021/jo00296a061research-articleACS PublicationsRequest reuse permissionsArticle Views765Altmetric-Citations49LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
An Orally Available Tubulin Inhibitor, VERU-111, Suppresses Triple-Negative Breast Cancer Tumor Growth and Metastasis and Bypasses Taxane Resistance (2019)

Abstract Triple-negative breast cancer (TNBC) accounts for approximately 15% of breast cancer cases in the United States. TNBC has poorer overall prognosis relative to other molecular subtypes due to rapid onset of drug resistance to conventional chemotherapies and increased risk of visceral metastases. Taxanes like paclitaxel are standard chemotherapies that stabilize microtubules, but their clinical efficacy is often limited by drug resistance and neurotoxicities. We evaluated the preclinical efficacy of a novel, potent, and orally bioavailable tubulin inhibitor, VERU-111, in TNBC models. VERU-111 showed potent cytotoxicity against TNBC cell lines, inducing apoptosis and cell-cycle arrest in a concentration-dependent manner. VERU-111 also efficiently inhibited colony formation, cell migration, and invasion. Orally administered VERU-111 inhibited MDA-MB-231 xenograft growth in a dose-dependent manner, with similar efficacies to paclitaxel, but without acute toxicity. VERU-111 significantly reduced metastases originating from the mammary fat pad into lung, liver, and kidney metastasis in an experimental metastasis model. Moreover, VERU-111, but not paclitaxel, suppressed growth of luciferase-labeled, taxane-resistant, patient-derived metastatic TNBC tumors. In this model, VERU-111 repressed growth of preestablished axillary lymph node metastases and lung, bone, and liver metastases at study endpoint, whereas paclitaxel enhanced liver metastases relative to vehicle controls. Collectively, these studies strongly suggest that VERU-111 is not only a potent inhibitor of aggressive TNBC phenotypes, but it is also efficacious in a taxane-resistant model of metastatic TNBC. Thus, VERU-111 is a promising new generation of tubulin inhibitor for the treatment of TNBC and may be effective in patients who progress on taxanes. Results presented in this study demonstrate the efficacy of VERU-111 in vivo and provide strong rationale for future development of VERU-111 as an effective treatment for metastatic breast cancer.
LASER FLASH PHOTOLYSIS STUDY OF PHENYLCARBENE,o-TOLYLCARBENE AND MESITYLCARBENE (1997)

Laser flash photolysis (LFP, XeCl, 308 nm, 20 ns) of phenyldiazomethane (PDM), o-tolydiazomethane (TDM) and mesitydiazomethane (MDM) produces phenylcarbene (PC), o-tolycarbene (TC) and mesitylcarbene (MSC), respectively. Transient spectra of PC and TC could not be detected in pentane at ambient temperature; however, these carbenes could be trapped with pyridine to form UV–Vis-active ylides. The rate of formation of these ylides was resolved in CF2ClCFCl2 (Freon-113) and yields, after analysis, values of kpyr and τ, where kpyr is the absolute rate constant of the reaction of the spin equilibrated carbene with pyridine and τ is the carbene lifetime in Freon-113 in the absence of pyridine. LFP of MDM produces the transient spectra of both triplet MSC and 3,5-dimethyl-1,2-benzoquinodimethane (3,5-BQM). The lifetime of 3MSC in pentane is ca 500 ns. 3MSC reacts with pyridine with an apparent rate constant of kpyr=1·35×107 M−1 s−1. The decay of 3MSC in a variety of solvents does not lead to increased absorption of 3,5-BQM in solution, nor does the presence of a carbene scavenger (methanol) lead to a reduction in yield of 3,5-dimethyl-1,2-benzoquinodimethane upon LFP of precursor. Thus, the decay of 3MSC in solution does not lead to the formation of quinodimethane. This species (3,5-BQM) is formed, instead, by a hydrogen atom transfer in the excited state of the precursor. Product analysis reveals that the excited state rearrangement which forms xylylene is a minor process. Photolysis of MDM in a nitrogen matrix at 10 K leads to the UV–Vis spectra of matrix-isolated triplet mesitylcarbene and 3,5-BQM. The carbene rearranges slowly to 3,5-BQM in the cryogenic matrix, in contrast to its behavior in solution. © 1997 John Wiley & Sons, Ltd.
Fine self-tuning method of both current sensor offset and electrical parameter variations for SPM motor (2010)

The servo system of a permanent magnet (PM) motor is always required to maintain fine torque and speed response. The current-control system is designed by using the electric parameters of the PM motor. However, motor parameters vary and the current sensors have offset values. When each U-phase and V-phase current sensor has an offset value, the PM motor servo system has the torque ripple and cannot accurately identify the motor parameters. In this paper, we propose a new online-estimation method for both current-sensor offsets and electrical parameters for PM motors by using a current simulator. The experimental results confirm that the proposed method accurately estimates both the U-phase and V-phase current sensor offsets, the motor resistance R <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">a</sub> , the motor inductance L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">a</sub> , and carries out the fine self-tuning for the current controller of PM motor servo system.
Activated carbon cloth filled pipette tip for solid phase extraction of nickel(II), lead(II), cadmium(II), copper(II) and cobalt(II) as 1,3,4-thiadiazole-2,5-dithiol chelates for ultra-trace detection by FAAS (2018)

A solid phase extraction method is established for preconcentration of nickel, lead, cadmium, copper and cobalt using pipette tip solid phase extraction. The presented process was dependent on chelation of analytes with 1,3,4-thiadiazole-2,5-dithiol, then allowing the solution to flow through an activated carbon cloth packed pipette tip. The adsorbed metal chelates on the surface of activated carbon cloth were eluted by 5 mL of 3 M HNO3. The concentrations of nickel, lead, cadmium, copper and cobalt were detected using a flame atomic absorption spectrometer (FAAS). The pipette tip solid phase extraction exhibit a preconcentration factor of 120. The limit of detection values were 2.7, 1.7, 1.3, 2.0 and 2.9 µg L−1 for Ni(II), Pb(II), Cd(II), Cu(II) and Co(II), respectively. Validation of the method was checked by the analysis of TMDA-53.3 and TMDA-64.2 certified reference materials. The method was successfully applied for water and fertiliser samples.