gebhart/patrepeval huggingface dataset:
Modulation of brain NMDA receptors: common mechanism of sigma/PCP receptors and their exogenous and endogenous ligands. (1986)

Quantitative autoradiographic distribution patterns of sigma/PCP and NMDA receptors show striking similarities but not in all brain areas. We have identified an endogenous ligand of brain PCP receptors which noncompetitively antagonizes NMDA-induced neurotransmitter release from brain slices. These data support the concept that the sigma/PCP receptor ligands may exert their unique behavioral effects by indirect modulation of NMDA-mediated transmission.
ChemInform Abstract: NUCLEOSIDES AND NUCLEOTIDES. PART 21. SYNTHESIS OF A TRIDECANUCLEOSIDE DODECAPHOSPHATE INCORPORATING THE UNNATURAL BASE 2(1H)‐PYRIDONE (1983)

Abstract Durch Kondensation schrittweise aufgebauter entsprechender Unterfragmente bzw. Fragmente (Triester‐ Verfahren; die Diester‐Methode ist unbefriedigend) wird das Titelnucleotid (I) synthetisiert.
On‐line measurement of chlorobenzene in waste incineration flue gas as a surrogate for the emission of polychlorinated dibenzo‐p‐dioxins/furans (I‐TEQ) using mobile resonance laser ionization time‐of‐flight mass spectrometry (1999)

Mobile resonance-enhanced multiphoton ionization time-of-flight mass spectrometry (REMPI-TOFMS) was applied for on-line detection of surrogates for polychlorinated dibenzo-p-dioxins/furans (PCDD/F) in the flue gas of an industrial hazardous waste incineration plant (thermal power: 22 MW). Conventional gas chromatography/mass spectrometry (GC/MS) measurements have been performed to establish an indicator relation between the best suited surrogate (monochlorobenzene) and the PCDD/F concentration in the flue gas (measured in international toxicity equivalents, I-TEQ). The indicator relation allows the estimation of the actual PCDD/F emission from the on-line registered MCBz signal. Furthermore, several other aromatic components have been measured on-line. During transient instabilities of the combustion conditions, e.g. due to barrel uptake, highly dynamic changes in the emission profiles of substituted benzenes and polycyclic aromatic hydrocarbons (PAH) were observed. Copyright © 1999 John Wiley & Sons, Ltd.
On the Capacity ofNon-Coherent Network Coding (2009)

bits. However, this resultassumes that the receivers know perfectly the operations thatthe network nodes perform. In practical networks, where suchdeterministic knowledge is not sustainable, the most popularapproach is to append coding vectors at the headers of thepackets to keep track of the linear combinations of the sourcepackets they contain. This results in a loss of information ratewith respect to the min-cut value. In a sense, this is akin totraining symbols to learn the transformation induced by thenetwork. Recently, algebraic subspace coding constructionshave been proposed as a method that allows to achieve higherinformation rates by dispensing of the need for the codingvector overheads [3]. In this paper we examine what are theinformation theoretical rates that can be achieved in a networkwhere the intermediate node operations are unknown.We consider a network where neither the source nor thereceivers have knowledge of the network topology or of thelinear coding operations the network nodes perform. In [6] weproposed a model to capture this communication, where thesource inserts in the network m packets of length T over somefinite field IF
Porous Silicon Nanoparticles Targeted to the Extracellular Matrix for Therapeutic Protein Delivery in Traumatic Brain Injury (2022)

Traumatic brain injury (TBI) is a major cause of disability and death among children and young adults in the United States, yet there are currently no treatments that improve the long-term brain health of patients. One promising therapeutic for TBI is brain-derived neurotrophic factor (BDNF), a protein that promotes neurogenesis and neuron survival. However, outstanding challenges to the systemic delivery of BDNF are its instability in blood, poor transport into the brain, and short half-life in circulation and brain tissue. Here, BDNF is encapsulated into an engineered, biodegradable porous silicon nanoparticle (pSiNP) in order to deliver bioactive BDNF to injured brain tissue after TBI. The pSiNP carrier is modified with the targeting ligand CAQK, a peptide that binds to extracellular matrix components upregulated after TBI. The protein cargo retains bioactivity after release from the pSiNP carrier, and systemic administration of the CAQK-modified pSiNPs results in effective delivery of the protein cargo to injured brain regions in a mouse model of TBI. When administered after injury, the CAQK-targeted pSiNP delivery system for BDNF reduces lesion volumes compared to free BDNF, supporting the hypothesis that pSiNPs mediate therapeutic protein delivery after systemic administration to improve outcomes in TBI.
CLAMP-ON, SONAR-BASED ENTRAINED AIR MEASURMENT FOR PULP AND PAPER APPLICATIONS (2004)

SONARtrac flow meters represent a new class of clamp-on flow monitoring technology well-suited for paper and pulp applications. Separate and distinct from ultrasonic technology, SONARtrac devices utilize clamp-on, strain-based sensors combined with sonar processing techniques to simultaneously measure the percent of entrained air present in a paper or pulp slurry as well as measure the volumetric flow rate of that slurry on a real time basis. To measure entrained air, the meter utilizes the sensor array to determine the speed at which naturally occurring, process-generated sound propagates through the process fluid. The speed of sound measurement is then used to determine entrained air levels accurate to within 0.01 % for typical paper and pulp applications. In addition to entrained air measurement, sonar-based meters can also provide volumetric flow measurement by tracking the speed at which naturally occurring turbulent structures convect with the flow past the same sensor array. By utilizing these two, first-principles based measurements to track the naturally occurring pressure field within process piping, sonar-based flow monitoring systems provide new insight to multi-phase flow for the pulp and paper industry.
Borderline Resectable and Locally Advanced Pancreatic Cancer: FDG PET/MRI and CT Tumor Metrics for Assessment of Pathologic Response to Neoadjuvant Therapy and Prediction of Survival (2020)

<b>BACKGROUND.</b> Imaging biomarkers of response to neoadjuvant therapy (NAT) for pancreatic ductal adenocarcinoma (PDA) are needed to optimize treatment decisions and long-term outcomes. <b>OBJECTIVE.</b> The purpose of this study was to investigate metrics from PET/MRI and CT to assess pathologic response of PDA to NAT and to predict overall survival (OS). <b>METHODS.</b> This retrospective study included 44 patients with <sup>18</sup>F-FDG-avid borderline resectable or locally advanced PDA on pretreatment PET/MRI who also underwent post-NAT PET/MRI before surgery between August 2016 and February 2019. Carbohydrate antigen 19-9 (CA 19-9) level, metabolic metrics from PET/MRI, and morphologic metrics from CT (<i>n</i> = 34) were compared between pathologic responders (College of American Pathologists scores 0 and 1) and nonresponders (scores 2 and 3). AUCs were measured for metrics significantly associated with pathologic response. Relation to OS was evaluated with Cox proportional hazards models. <b>RESULTS.</b> Among 44 patients (22 men, 22 women; mean age, 62 ± 11.6 years), 19 (43%) were responders, and 25 (57%) were nonresponders. Median OS was 24 months (range, 6-42 months). Before treatment, responders and nonresponders did not differ in CA 19-9 level, metabolic metrics, or CT metrics (<i>p</i> > .05). After treatment, responders and nonresponders differed in complete metabolic response (CMR) (responders, 89% [17/19]; nonresponders, 40% [10/25]; <i>p</i> = .04], mean change in SUV<sub>max</sub> (ΔSUV<sub>max</sub>; responders, -70% ± 13%; nonresponders, -37% ± 42%; <i>p</i> < .001), mean change in SUV<sub>max</sub> corrected to serum glucose level (ΔSUV<sub>gluc</sub>) (responders, -74% ± 12%; nonresponders, -30% ± 58%; <i>p</i> < .001), RECIST response on CT (responders, 93% [13/14]; nonresponders, 50% [10/20]; <i>p</i> = .02)], and mean change in tumor volume on CT (ΔTvol) (responders, -85% ± 21%; nonresponders, 57% ± 400%; <i>p</i> < .001). The AUC of CMR for pathologic response was 0.75; ΔSUV<sub>max</sub>, 0.83; ΔSUV<sub>gluc</sub>, 0.87; RECIST, 0.71; and ΔTvol 0.86. The AUCs of bivariable PET/MRI and CT models were 0.83 (CMR and ΔSUV<sub>max</sub>), 0.87 (CMR and ΔSUV<sub>gluc</sub>), and 0.87 (RECIST and ΔTvol). OS was associated with CMR (<i>p</i> = .03), ΔSUV<sub>max</sub> (<i>p</i> = .003), ΔSUV<sub>gluc</sub> (<i>p</i> = .003), and RECIST (<i>p</i> = .046). <b>CONCLUSION.</b> Unlike CA 19-9 level, changes in metabolic metrics from PET/MRI and morphologic metrics from CT after NAT were associated with pathologic response and OS in patients with PDA, warranting prospective validation. <b>CLINICAL IMPACT.</b> Imaging metrics associated with pathologic response and OS in PDA could help guide clinical management and outcomes for patients with PDA who undergo emergency therapeutic interventions.
The ROX coupler: Creation of a fixed iliac arteriovenous anastomosis for the treatment of uncontrolled systemic arterial hypertension, exploiting the physical properties of the arterial vasculature (2014)

A novel arteriovenous coupler for percutaneous placement in the iliac vasculature is under clinical investigation as a potential treatment modality for selected patients with uncontrolled hypertension. Initial results from patients with uncontrolled hypertension are expected in Autumn 2014.
Predicting Speech Intelligibility from a Population of Neurons (2003)

A major issue in evaluating speech enhancement and hearing compensation algorithms is to come up with a suitable metric that predicts intelligibility as judged by a human listener. Previous methods such as the widely used Speech Transmission Index (STI) fail to account for masking effects that arise from the highly nonlinear cochlear transfer function. We therefore propose a Neural Articulation Index (NAI) that estimates speech intelligibility from the instantaneous neural spike rate over time, produced when a signal is processed by an auditory neural model. By using a well developed model of the auditory periphery and detection theory we show that human perceptual discrimination closely matches the modeled distortion in the instantaneous spike rates of the auditory nerve. In highly rippled frequency transfer conditions the NAI’s prediction error is 8 % versus the STI’s prediction error of 10.8%. 1
A noninvasive postoperative clinical score to identify patients at risk for postoperative pulmonary complications: the Air-Test Score (2020)

The simple, non-invasive and inexpensive bedside air-test score, evaluating pre- and postoperatively SpO2 measured on room-air, helps to predict the risk for PPCs.
Both CXCR3 and CXCL10/IFN-Inducible Protein 10 Are Required for Resistance to Primary Infection by Dengue Virus (2006)

We examined the extent to which CXCR3 mediates resistance to dengue infection. Following intracerebral infection with dengue virus, CXCR3-deficient (CXCR3(-/-)) mice showed significantly higher mortality rates than wild-type (WT) mice; moreover, surviving CXCR3(-/-) mice, but not WT mice, often developed severe hind-limb paralysis. The brains of CXCR3(-/-) mice showed higher viral loads than those of WT mice, and quantitative analysis using real-time PCR, flow cytometry, and immunohistochemistry revealed fewer T cells, CD8(+) T cells in particular, in the brains of CXCR3(-/-) mice. This suggests that recruitment of effector T cells to sites of dengue infection was diminished in CXCR3(-/-) mice, which impaired elimination of the virus from the brain and thus increased the likelihood of paralysis and/or death. These results indicate that CXCR3 plays a protective rather than an immunopathological role in dengue virus infection. In studies to identify critical CXCR3 ligands, CXCL10/IFN-inducible protein 10-deficient (CXCL10/IP-10(-/-)) mice infected with dengue virus showed a higher mortality rate than that of the CXCR3(-/-) mice. Although CXCL10/IP-10, CXCL9/monokine induced by IFN-gamma, and CXCL11/IFN-inducible T cell alpha chemoattractant share a single receptor and all three of these chemokines are induced by dengue virus infection, the latter two could not compensate for the absence of CXCL10/IP-10 in this in vivo model. Our results suggest that both CXCR3 and CXCL10/IP-10 contribute to resistance against primary dengue virus infection and that chemokines that are indistinguishable in in vitro assays differ in their activities in vivo.
Cloning of Phospholipid Hydroperoxide Glutathione Peroxidase (PHGPx) as an anti‐apoptotic and growth promoting gene of Burkitt Lymphoma cells (2001)

Burkitt Lymphoma (BL) cells are highly sensitive to suboptimal growth conditions and undergo apoptosis when seeded at low cell density or reduced serum concentration. Irradiated fibroblasts or a mix of pruvate, alpha-thioglycerol, and bathocuproine disulfonate can protect BL cells from apoptosis induced by lowering cell density or serum concentration by promoting cystine uptake in the cells. The availability of cystine is the limiting factor for glutathione biosynthesis in BL cells and thus for the ability of the cells to cope with oxidative stress. We have set up an expression cloning strategy to clone genes that protect BL cells from apoptosis induced by low cell density and/or serum. Using this approach we have cloned among others the cDNA for Phospholipid Hydroperoxide Glutathione Peroxidase (PHGPx).
Role of Platelets in Hypercholesterolemia‐Induced Leukocyte Recruitment and Arteriolar Dysfunction (2006)

The findings indicate that platelet-associated P-selectin contributes to the recruitment of leukocytes and platelets in venules of hypercholesterolemic mice and that the P-selectin-mediated adhesive interactions also contribute to the impaired arteriolar function induced by hypercholesterolemia.
Coupling strategy between high-index and mid-index micro-metric waveguides for O-band applications (2022)

The integration of fast and power efficient electro-absorption modulators on silicon is of utmost importance for a wide range of applications. To date, Franz-Keldysh modulators formed of bulk Ge or GeSi have been widely adopted due to the simplicity of integration required by the modulation scheme. Nevertheless, to obtain operation for a wider range of wavelengths (O to C band) a thick stack of Ge/GeSi layers forming quantum wells is required, leading to a dramatic increase in the complexity linked to sub-micron waveguide coupling. In this work, we present a proof-of-concept integration between micro-metric waveguides, through the butt-coupling of a [Formula: see text] thick N-rich silicon nitride (SiN) waveguide with a [Formula: see text] thick silicon waveguide for O-band operation. A numerical analysis is conducted for the design of the waveguide-to-waveguide interface, with the aim to minimize the power coupling loss and back-reflection levels. The theoretical results are compared to the measured data, demonstrating a coupling loss level of [Formula: see text] for TE and TM polarisation. Based on the SiN-SOI interconnection simulation strategy, the simulation results of a quantum-confined Stark effect (QCSE) stack waveguide coupled to a SiN waveguide are then presented.
Influence of dental amalgam and heavy metal cations onin vitro interleukin-1? production by human peripheral blood mononuclear cells (2000)

The influence of dental amalgam and heavy metal cations on interleukin-1beta (IL-1beta) expression by peripheral blood mononuclear cells from healthy donors was studied. A marked decrease in the production of IL-1beta was caused by freshly prepared amalgam or amalgam-conditioned culture medium, but not by amalgam aged for 6 weeks. When metal cations were added as salts, Cu(2+), Hg(2+), and Ag(+) at high concentrations (33.3 and 333.3 microM) were highly inhibitory. Among other heavy metal cations, Au(3+), Pt(4+), Ni(2+), Pd(2+), but not Ga(3+) or Sn(2+), inhibited IL-1beta production in a concentration-dependent manner. Flow cytometry studies indicated that Hg(2+) and Ag(+) strongly reduced the percentage of CD14(+) cells containing IL-1beta intracellularly. As shown by Northern blot analysis, Hg(2+) inhibited the level of IL-1beta-specific mRNA by 28% at 3.3 microM and completely at 33.3 microM. Only slight inhibitory effects were induced by Cu(2+) at 33.3 microM. Interestingly, Ag(+) at a concentration of 3.3 microM increased twofold the amount of IL-1beta-specific mRNA. Our data show that IL-1beta production is altered at protein and mRNA levels by components released from fresh amalgam and by other heavy metal cations, suggesting a role of these cations in changes in the cell phenotype and IL-1-mediated cell functions.
Formation of titanium nitride by annealing Ag/Ti structures in ammonia ambient (1997)

Titanium nitride thin films have been formed in the temperature range of 400–600 °C by annealing Ag/Ti bilayer films on oxidized Si substrates in an ammonia ambient. Rutherford backscattering spectrometry and Auger depth profiling have shown the segregation of Ti at the surface and at interface. Ti diffused out through the silver layer and reacted with ammonia to form a TiN layer that self-encapsulated the silver film. A near-bamboo structure in the encapsulated Ag films was observed using cross-sectional transmission electron microscopy. Such a structure is expected to improve the electromigration resistance of the silver metallization. The kinetics of the Ti-nitride growth was studied by investigating its dependence on time, temperature, and Ag/Ti bilayer thicknesses. We also found that two processes govern the nitridation reaction. A dominant nitridation process takes place initially at fast growth rates. After 15 min anneals the nitride growth can be described by x2=B t, where B is a parabolic rate constant for the growing nitride phase. The parabolic rate constants follow an Arrhenius behavior with an apparent activation energy of ∼0.4 eV. These observations led to further discussion regarding the diffusion mechanism as well as the rate-limiting step.
X-Ray and Fast Neutron Radiographic Performance of an Ir-Bi-Plastic Array (2022)

Organic plastic scintillators offer the potential for exciting improvements in particle interaction efficiency, light yield (LY), and pulse shape discrimination (PSD). An area of particular application for select plastics exists in portable dual-particle imaging (DPI) systems supporting nuclear safety, security, and safeguards missions. One promising material, an Ir-Bi-Plastic, is experimentally evaluated within separate 370 kVp X-ray and 14.1 MeV neutron fields in the form of a pixelated array, which was fabricated by Lawrence Livermore National Laboratory (LLNL). Ir-Bi-Plastics pair high bismuth loadings with iridium-complex fluorophores to provide high intrinsic efficiencies for both photoelectric absorption and fast neutron detection, as well as improved LYs from the triplet-harvesting capabilities of the iridium-complex. These attributes make Ir-Bi-Plastics ideal candidates for DPI applications. Radiographic performance results for the Ir-Bi-Plastic array are compared against similar evaluations of smaller arrays made from EJ-200 and EJ-256, both industry standard materials. Measurements were recorded by pressure-coupling the three arrays to a commercial a-Si digital radiographic panel, and ASTM standard test methods and practices were utilized to calculate the modulation transfer function (MTF) and limits of spatial resolution for all three arrays. The results suggest the Ir-Bi-Plastic array, despite its larger pixel pitch, provides significantly improved performance over equivalent arrays made from either EJ-200 or EJ-256 for all X-ray and fast neutron environments practical for portable DPI.
Low-Yellowing Phosphor-in-Glass for High-Power Chip-on-board White LEDs by Optimizing a Low-Melting Sn-P-F-O Glass Matrix (2018)

We introduce a low-melting-point (MP) Sn-P-F-O glass ceramic material into the phosphor-in-glass (PIG) material to realize an 'on-chip' chip-on-board (COB) type of phosphor-converted (pc) white light-emitting diode (WLED) with green (BaSr)<sub>2</sub>SiO<sub>4</sub>:Eu<sup>2+</sup> and red (SrCa)AlSiN<sub>3</sub>:Eu<sup>2+</sup> (SCASN) phosphors. The optimum Sn-P-F-O-based ceramic components can be sintered into the glass phase with a facile one-step heating process at 285 °C for 1 min. Specifically, these soft-fabrication conditions can be optimized to minimize the degradation of the luminescent properties of the red SCASN phosphor as well as the green silicate phosphor in PIG-based white COB-type pc-LEDs owing to the low thermal loss of the phosphors at low fabrication temperatures below 300 °C. Moreover, the constituents of the COB package, in this case the wire bonding and plastic exterior, can be preserved simultaneously from thermal damage. That is, the low sintering temperature of the glass ceramic encapsulant is a very important factor to realize excellent optical qualities of white COB LEDs. The optical performances of low-MP Sn-P-F-O-based PIG on-chip COB-type pc-WLEDs exhibit low yellowing phenomena, good luminous efficacy of 70.9-86.0 lm/W, excellent color rendering index of 94-97 with correlated color temperatures from 2700 to 10000 K, and good long-term stability.
Design and Implementation of IoT Collaboration Module Supporting User Context Management (2015)

Various personalized services are provided based on user context these days, and IoT(Internet of Things) devices provides effective ways to collect user context. For example, user's activity such as walking steps, calories, and sleeping hours can be collected using smart activity tracker. Smart scale can sense change of user's weight or body fat percentage. However, these services are independent to each other and not easy to make them collaborate. Many standard bodies are working on the documents for this issue, but due to diversity of IoT use case scenarios, it seems that multiple IoT technologies co-exist for the time being. This paper propose a framework to collaborate heterogeneous IoT services. The proposed framework provides methods to build application for heterogeneous IoT devices and user context management in more intuitive way using HTTP. To improve compatibility and usability, gathered user contexts are based on MPEG-UD. Implementation of framework and service with real-world devices are also presented.
Hydrogen storage in carbon nanotubes: Residual metal content and pretreatment temperature (2003)

Abstract Hydrogen storage in MWNT was enhanced via the catalytic activity of NiMgO. The magnitude of the hydrogen to metal ratio for the MWNT/NiMgO system, combined with temperature programmed adsorption and desorption studies, showed hydrogen spillover from the catalyst to the carbon surface. Metal doping combined with temperature activation studies showed that both nickel and magnesium are active in the catalytic process. The yield, quality, and carbon‐metal contact were shown to affect hydrogen uptake. Higher pretreatment temperatures enhanced uptake, for both low‐ and high‐pressure measurements, due to increased carbon‐metal contact and activation of the catalyst. At 69 bar (or 1,000 psia), the hydrogen adsorption and desorption of the MWNT/NiMgO system were 3.7% and 3.6%, respectively.
Reliability Issues in Photovoltaic Power Processing Systems (2008)

Power processing systems will be a key factor of future photovoltaic (PV) applications. They will play a central role in transferring, to the load and/or to the grid, the electric power produced by the high-efficiency PV cells of the next generation. In order to come up the expectations related to the use of solar energy for producing electrical energy, such systems must ensure high efficiency, modularity, and, particularly, high reliability. The goal of this paper is to provide an overview of the open problems related to PV power processing systems and to focus the attention of researchers and industries on present and future challenges in this field.