gebhart/patrepeval huggingface dataset:
One Model to Rule them All: Towards Zero-Shot Learning for Databases (2021)

In this paper, we present our vision of so called zero-shot learning for databases which is a new learning approach for database components. Zero-shot learning for databases is inspired by recent advances in transfer learning of models such as GPT-3 and can support a new database out-of-the box without the need to train a new model. Furthermore, it can easily be extended to few-shot learning by further retraining the model on the unseen database. As a first concrete contribution in this paper, we show the feasibility of zero-shot learning for the task of physical cost estimation and present very promising initial results. Moreover, as a second contribution we discuss the core challenges related to zero-shot learning for databases and present a roadmap to extend zero-shot learning towards many other tasks beyond cost estimation or even beyond classical database systems and workloads.
Molecular Imaging of Cancer Using Fluorescent Probe Technology (2003)

Clinical imaging is the traditional cornerstone of cancer diagnosis. Detailed anatomic, physiologic, and metabolic information can be obtained by conventional techniques, such as X-ray, computed tomography (CT), ultrasound, nuclear, and magnetic resonance imaging (MRI). In our opinion, the next major advance in clinical imaging will be the ability to image specific molecules and molecular function, broadly encompassed in the field of molecular imaging. Molecular imaging couples sensitive clinical imaging systems with “smart” probes that interact with specific molecules. With this approach, image contrast can be directly ascribed to the presence or function of a target molecule. Ultimately, molecular imaging of tumor receptors and enzyme function is expected to have a major impact in the diagnosis and treatment of cancer, as well as in the field of cancer biology (1).
[Regulation of cell growth by retinoids and gene expression]. (1986)

Retinoids are compounds that can elicit specific biological responses by virtue of their binding to and activating a specific receptor or a set of receptors. Retinoids produce various specific biological effects, including induction of terminal differentiation, regulation of cell proliferation, regulation of gene expression and regulation of the activity of specific enzymes in cells. In this article, the effects of retinoids on gene expression are reviewed. Among these effects suppression of myc expression and induction of EGF-receptor mRNA expression are considered to be closely related to regulation of cell proliferation. The effects of retinoids on cell growth are discussed on the basis of these two actions: myc mRNA suppression and EGFR mRNA induction. The mode of retinoidal action seems to be similar to that of steroids, as many investigators suggest. The molecular mechanism of retinoidal action is considered to be the formation of a retinoid-receptor complex and its interaction with regulatory elements of DNA. The possibility of application of the methodology used in the investigation of steroidal action to the study of retinoidal action is also discussed.
Control for autonomous vehicles in collision avoidance maneuvers : LPV modeling and static feedback controller (2021)

This article presents a state feedback control design strategy for the stabilization of a vehicle along a reference collision avoidance maneuver. The stabilization of the vehicle is achieved through a combination of steering, acceleration and braking. A Linear Parameter-Varying (LPV) model is obtained from the linearization of a non-linear model along the reference trajectory. A robust state feedback control law is computed for the LPV model. Finally, simulation results illustrate the stabilization of the vehicle along the reference trajectory.
Infrared mapping of galaxian centers: star forming regions with kiloparsec scale sizes. (1984)

A 1 to 20 micron mapping of the centers of galaxies encompassing the regions that extend out to several kiloparsecs from the nuclei is reviewed. Power emerging at or = 5 microns is a direct measure of the number of young stars present. This conclusion is strongly supported by the large-scale association of the infrared-emitting regions with visual continuum and line emission indicative of young stars, and by the similarity of the energy distributions to those of Galactic HII region/molecular cloud complexes. Much of the young-star activity is completely hidden from view. At shorter wavelengths, a variety of processes, including bremsstrahlung, are evident.
Refined mapping of two regions of loss of heterozygosity on chromosome band 11q23 in lung cancer (1999)

11q23–24 chromosome is a region containing frequent allelic loss (loss of heterozygosity; LOH) in human cancers. To examine cancer-related allelic loss in the region between D11S940 and APOC3, we used 17 polymorphic markers and allotyped 28 lung cancer-derived cell lines and their corresponding matched lymphoblastoid cell lines. LOH was found in 71.4% (20/28) of the lung cancer cell lines and was localized to two distinct minimal regions of loss. One region is bracketed by markers D11S1647 and NCAM2 and contains the gene encoding the β isoform of the A subunit of the human protein phosphatase 2A (PPP2R1B). Recently, mutations in this gene were described in lung and colon cancers, suggesting that PPP2R1B functions as a tumor-suppressor gene. A second minimal region of loss was defined between markers D11S1792 and D11S1885, a region estimated to be less than 1 Mb. Thus, chromosome 11 likely harbors two sites of suppressor oncogene activity in lung cancer, one defined by the PPP2R1B gene and the second located telomeric to PPP2R1B. This study facilitates the identification and cloning of a second critical tumor-suppressor gene involved in lung cancer, and possibly a variety of other cancers, on human chromosome band 11q23. Genes Chromosomes Cancer 25:154–159, 1999. © 1999 Wiley-Liss, Inc.
Regional White Matter Diffusion Changes Associated with the Cumulative Tensile Strain and Strain Rate in Nonconcussed Youth Football Players (2021)

The purpose of this study is to assess the relationship between regional white matter diffusion imaging changes and finite element strain measures in nonconcussed youth football players. Pre- and post-season diffusion-weighted imaging was performed in 102 youth football subject-seasons, in which no concussions were diagnosed. The diffusion data were normalized to the IXI template. Percent change in fractional anisotropy (%ΔFA) images were generated. Using data from the head impact telemetry system, the cumulative maximum principal strain one times strain rate (CMPS1<b> ×</b> SR), a measure of the cumulative tensile brain strain and strain rate for one season, was calculated for each subject. Two linear regression analyses were performed to identify significant positive or inverse relationships between CMPS1<b> ×</b> SR and %ΔFA within the international consortium for brain mapping white matter mask. Age, body mass index, days between pre- and post-season imaging, previous brain injury, attention disorder diagnosis, and imaging protocol were included as covariates. False discovery rate correction was used with corrected alphas of 0.025 and voxel thresholds of zero. Controlling for all covariates, a significant, positive linear relationship between %ΔFA and CMPS1<b> ×</b> SR was identified in the bilateral cingulum, fornix, internal capsule, external capsule, corpus callosum, corona radiata, corticospinal tract, cerebral and middle cerebellar peduncle, superior longitudinal fasciculus, and right superior fronto-occipital fasciculus. <i>Post hoc</i> analyses further demonstrated significant %ΔFA differences between high-strain football subjects and noncollision control athletes, no significant %ΔFA differences between low-strain subjects and noncollision control athletes, and that CMPS1<b> ×</b> SR significantly explained more %ΔFA variance than number of head impacts alone.
Validation of picogram- and femtogram-input DNA libraries for microscale metagenomics (2016)

High-throughput sequencing libraries are typically limited by the requirement for nanograms to micrograms of input DNA. This bottleneck impedes the microscale analysis of ecosystems and the exploration of low biomass samples. Current methods for amplifying environmental DNA to bypass this bottleneck introduce considerable bias into metagenomic profiles. Here we describe and validate a simple modification of the Illumina Nextera XT DNA library preparation kit which allows creation of shotgun libraries from sub-nanogram amounts of input DNA. Community composition was reproducible down to 100 fg of input DNA based on analysis of a mock community comprising 54 phylogenetically diverse Bacteria and Archaea. The main technical issues with the low input libraries were a greater potential for contamination, limited DNA complexity which has a direct effect on assembly and binning, and an associated higher percentage of read duplicates. We recommend a lower limit of 1 pg (∼100-1,000 microbial cells) to ensure community composition fidelity, and the inclusion of negative controls to identify reagent-specific contaminants. Applying the approach to marine surface water, pronounced differences were observed between bacterial community profiles of microliter volume samples, which we attribute to biological variation. This result is consistent with expected microscale patchiness in marine communities. We thus envision that our benchmarked, slightly modified low input DNA protocol will be beneficial for microscale and low biomass metagenomics.
The origin of cellular life (2000)

This essay presents a scenario of the origin of life that is based on analysis of biological architecture and mechanical design at the microstructural level. My thesis is that the same architectural and energetic constraints that shape cells today also guided the evolution of the first cells and that the molecular scaffolds that support solid-phase biochemistry in modern cells represent living microfossils of past life forms. This concept emerged from the discovery that cells mechanically stabilize themselves using tensegrity architecture and that these same building rules guide hierarchical self-assembly at all size scales (Sci. Amer 278:48-57;1998). When combined with other fundamental design principles (e.g., energy minimization, topological constraints, structural hierarchies, autocatalytic sets, solid-state biochemistry), tensegrity provides a physical basis to explain how atomic and molecular elements progressively self-assembled to create hierarchical structures with increasingly complex functions, including living cells that can self-reproduce.
Negotiable Auction Based on Mixed Graph: A Novel Spectrum Sharing Framework (2017)

Auction-based spectrum sharing is a promising solution to improve the spectrum utilization in 5G networks. Along with the spatial reuse, we observe that the ability to adjust the coverage of a spectrum bidder can provide room to itself for further negotiation while auctioning. In this paper, we propose a novel economic tool, size-negotiable auction mechanism (SNAM), which provides a hybrid solution between auction and negotiation for multi-buyers sharing spectrum chunks from a common database. Unlike existing auction-based spectrum sharing models, each bidder of the SNAM submits its bid for using the spectrum per unit space and a set of coverage ranges over which the bidder is willing to pay for the spectrum. The auctioneer then coordinates the interference areas (or coverage negotiation) to ensure no two winners interfere with each other while aiming to maximize the auction's total coverage area or revenue. In this scenario, the undirected graph used by existing auction mechanisms fails to model the interference among bidders. Instead, we construct a mixed interference graph and prove that SNAM's auctioning on the mixed graph is truthful and individually rational. Simulation results show that, compared with existing auction approaches, the proposed SNAM dramatically improves the spatial efficiency, hence leads to significantly higher seller revenue and buyer satisfaction under various setups. Thanks to its low complexity and low overhead, SNAM can target fine timescale trading (in minutes or hours) with a large number of bidders and requested coverages.
Toward Clinically Compatible Phase-Contrast Mammography (2015)

Phase-contrast mammography using laboratory X-ray sources is a promising approach to overcome the relatively low sensitivity and specificity of clinical, absorption-based screening. Current research is mostly centered on identifying potential diagnostic benefits arising from phase-contrast and dark-field mammography and benchmarking the latter with conventional state-of-the-art imaging methods. So far, little effort has been made to adjust this novel imaging technique to clinical needs. In this article, we address the key points for a successful implementation to a clinical routine in the near future and present the very first dose-compatible and rapid scan-time phase-contrast mammograms of both a freshly dissected, cancer-bearing mastectomy specimen and a mammographic accreditation phantom.
63.1: Invited Paper : Liquid Crystal Devices Based on Photo‐Alignment and Photo‐Patterning Materials (2011)

Abstract Liquid crystal devices based on photo‐alignment and photo‐patterning materials, were proposed, including patterned retarders for 3D applications, lenses with electrically tunable focal distance, LC based sensors, switchable q‐plates, and optically rewritable E‐paper. The photoalignment materials were mostly photosensitive azo‐dye layers. The combination of azo‐dye layers and liquid crystal polymers were also used for photo patterned phase retarders. The practical applications of new LC elements in 3D displays and other LC technology areas are envisaged.
Pharmacokinetics of the Antiviral Agent β- l -3′-Fluoro-2′,3′-Didehydro-2′,3′-Dideoxycytidine in Rhesus Monkeys (2005)

beta-L-3'-Fluoro-2',3'-didehydro-2',3'-dideoxycytidine (L-3'-Fd4C) is a potent and selective antiretroviral nucleoside with activity against lamivudine-resistant human immunodeficiency virus type 1 (HIV-1) and hepatitis B virus (HBV) in vitro. The pharmacokinetics of L-3'-Fd4C were characterized in three rhesus monkeys given single intravenous and oral doses. A two-compartment open model was fitted to the plasma and urine data. Plasma concentrations declined in a biexponential fashion with an average beta half-life of 12.45 h and central and steady-state volumes of distribution of 0.43 and 1.90 liters/kg, respectively. The average systemic and renal clearance values were 0.23 and 0.08 liters/kg, respectively, and the apparent mean terminal half-life of the oral dose was 12.5 h. The serum concentrations exceeded the 90% effective concentration value for lamivudine-resistant and wild-type HIV-1 after oral administrations. A large variation was observed in the oral bioavailability, which ranged from 15 to 31%. To determine whether the bioavailability may be improved by using a basic buffer solution, the oral dose was repeated to the same animals in a sodium bicarbonate solution. The bioavailability of L-3'-Fd4C administered with sodium bicarbonate was not significantly different from the bioavailability when the oral dose was administered in the absence of buffer (P = 0.49), suggesting that further development of this compound may warrant other approaches, such as development of a prodrug to improve its oral absorption.
<title>System approach to remote illumination design</title> (1998)

System concept implementation for the remote illumination system (RIS) design has been discussed. The relationship between application criteria and system specifications is formulated based on the RIS configuration. An engineering approach to RIS design, evaluation and optimization using system efficiency calculation is described.
Coherent Transfer Function* (1972)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text D. A. Tichenor and J. W. Goodman, "Coherent Transfer Function*," J. Opt. Soc. Am. 62, 293-295 (1972) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
AC-SONOS: a single-poly, assist-charge induced source-side-injection SONOS low power nonvolatile memory (2005)

A novel SONOS memory with an assist-charge (AC) structure is proposed to achieve both fast cell programming time of 0.1/spl mu/s and low programming current (<10/spl mu/).The assist-charge serves the function of a split gate and it electrically emulates programming by source-side injection (SSI). This very simple single-poly structure shows good promise for future low power, high speed and high-density applications.
Toward Biphasic Computed Tomography (CT) Enteric Contrast (2012)

Dual-energy CT and a bismuth-containing enteric contrast permitted simultaneous identification of hyperenhancing, hypoenhancing, and nonenhancing polyps over a range of patient sizes.
Nitsche-type Mortaring for Maxwell's Equations (2010)

We propose a new method for treating transmission conditions on non-matching meshes. The basic method is a hybrid version of Nitsche’s method. By introducing a scalar potential on the interface we obtain a robust method for the low frequency limit. In order to simplify numerical integration, we use smooth B-spline basis functions on the interface. We present the formulation for scalar potential problems and for time-harmonic Maxwell’s equations. A simple well logging example is used to benchmark the algorithm. 1.
Anti-LINGO-1 has no detectable immunomodulatory effects in preclinical and phase 1 studies (2017)

This study provides Class II evidence that in patients with MS, opicinumab does not have immunomodulatory effects detected by changes in immune gene transcript expression.
A novel metamaterial CRLH ZOR circular patch antenna capacitively coupled to a circular ring (2011)

In this paper, a novel circular patch antenna is proposed to have Zeroth Order Resonance(ZOR) generated based on the Metamaterial Composite Right- and Left-Handed(CRLH) structure. Making the in-phase electric field over the entire antenna other than a half-wavelength as the fundamental resonance mode of a ordinary microstrip patch or its positive multiple, the metallic patch is suggested to be capacitively coupled with only one surrounding circular ring, different from the previous 1D ZOR antennas commonly having several metal cells in line. The performance of the proposed antenna is simulated by a 3D field solver that inputs the sizes of the physical structure corresponding to the equivalent circuit designed to have ZOR at 2.4 GHz. Consequently, the resonance frequency, the gain and the antenna efficiency are observed 2.4 GHz, 5 dB and 98%, respectively. Besides, the important property of the proposed antenna is addressed as the combination of the low-cost low-profile as an advantage of microstrip patch antennas, and the omni-directional field pattern typical of monopole antennas.
Ceramic column grid array (CCGA) module for a high performance work station application (2002)

A multi-layer ceramic (MLC) substrate has been developed to package a 335 mm/sup 2/ silicon chip with a large number of transistors (15 million). The flip-chip required a package which can support a large number of I/O, and ability to cool 30 watts of power at 135 MHz. The large package pincount of 1088 led to the choice of a 42.5 mm substrate with a 1.27 mm pitch solder column grid array. In this paper, the chip and package attributes are described. A highly conductive thermal paste with a conductivity of 3.8 watt/m-deg. has been developed to provide an efficient thermal path from the flip-chip to the Al cap used on this package. Finally, the excellent reliability achieved by the column grid array connection to the second level organic card is discussed.
Defining the Role of Academic Advising in the Industrial Setting: The Next Phase (1981)

The turning of the calendar to 1981, in itself not an unexpected event, has been nevertheless the occasion for peering into the future to see what our world is becoming. On the basis of sound statistical indicators as well as more philosophical musings, higher education professionals have come to believe that higher education's viability depends on predicting oncoming events and developments. We have become a profession of futurists. If one accepts the proposition that anticipating the future is indeed a vital necessity in managing our programs and our institutions in the 1980's, we must become more skilled at describing the probable future, at assessing implications for today's decisions, and at integrating an evolving view of the future into evolving programs and institutions. Furthermore, we need to distinguish accurately those forces more or less inevitable and those forces that we may shape or alter through shrewd planning and decision-making. In effect, we need a conceptual framework for thinking about the future even a crudely formed one and a set of criteria for guiding our decisions. In an important, though neglected, area of higher education, academic advising, we will apply the logic of futuristic thinking. What environmental factors will affect academic advising in the 1980's? What areas are susceptible to shaping through our decision? What goals are the most realistic and the most appropriate? How d o we affect change?
Piezoceramic Electrodynamic Wireless Power Receiver Using Torsion Mode Meandering Suspension (2019)

This paper reports the design, fabrication and experimental characterization of an electrodynamic wireless power transmission (WPT) receiver that utilizes a meander-shaped suspension and two piezo-ceramic transducers to achieve up to 8.2 mW/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> · mT <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> normalized power density (NPD). The system operates at its torsion mode mechanical resonance of 211 Hz. The 2.5 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> prototype generates 3.3 mW average power (1.3 mW/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> power density) at a distance of 3 cm from a transmitter coil that is operating at the maximum allowable human exposure limit (a maximum 2 mT <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rms</sub> field generated at the center of the coil). Compared to prior works, the proposed design affords the use of multiple piezo transducers within a compact footprint while maintaining a form factor suitable for low-profile system implementation for bio-implantable and wearable applications.