gebhart/patrepeval huggingface dataset:
Right Ventricular Outflow Obstruction Secondary to Nonpenetrating Blunt Trauma to the Canine Myocardium (1982)

The purpose of this study was to investigate the development of a right ventricular (RV) outflow tract obstruction of sufficient severity to produce a systolic murmur following blunt cardiac trauma. A nonpenetrating impact directly on the anterior surface of the heart was produced in 34 open chest anesthetized dogs. Impact velocity was 12 m/sec in 15 dogs and 18 m/sec in 19 dogs. Seventeen dogs died immediately following impact. Pressures in the pulmonary artery and RV were measured during the control period in all dogs, and intermittently for 90 minutes following impact in ten of the 17 surviving dogs. At 90 minutes following impact a systolic pressure gradient of 9 +/- 2 mm Hg (range, 3 to 22 mm Hg) developed across the RV outflow tract and was associated with a prominent ejection murmur. At autopsy, RV wall thickness measured at the midventricular level was 13.5 +/- 1 mm (mean +/- SEM) which was thicker than in dogs that died immediately following impact, 6 +/- 1 mm (p less than 0.001). Microscopy of the RV myocardium of dogs that survived impact showed interstitial bleeding with prominent accumulations of blood between muscle bundles, whereas dogs that died immediately after impact showed no interstitial bleeding. The obstruction seems to have resulted from the increased RV wall thickness due to interstitial bleeding. In the absence, therefore, of other evidence to explain a new systolic murmur in patients following nonpenetrating cardiac trauma, the possibility of RV outflow obstruction might be considered.
Pyrido[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-diones: Synthesis, Cyclometalation, and Protein Kinase Inhibition (2005)

Synthetic routes to pyrido[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-diones are disclosed and examples for their subsequent transformations into cyclometalated protein kinase inhibitors are presented.
Supplementary Table S11 from Detection of Promoter DNA Methylation in Urine and Plasma Aids the Detection of Non–Small Cell Lung Cancer (2023)

&lt;p&gt;Univariate and multivariate logistic regression analysis for risk of having NSCLC in Black (n=38)&lt;/p&gt;
Techniques for implementation of at-speed testable, high performance, and low cost linear designs (2002)

Linear computations are most widely used type of ASIC computations. Due to their exceptional theoretical tractability and practical importance, numerous schemes for their implementation have been proposed. The canonical schemes have been widely studied and evaluated according to a number of important criteria, including the number of operations, number of bits, area, throughput and latency, and power metrics. However, until now the testability of linear systems was not studied. After we show that all the most widely used implementation structures require a significant testing related cost, we derive a new structure which is amenable for at-speed testing with no additional hardware overhead. Furthermore, the new structure provides a high throughput, low cost, and low power implementation for an arbitrary linear computation. The key technical novelties of the paper is a novel approach for use of transformations and coordinate use of transformations and scheduling for producing highly testable implementations.
Chitosan as a Water-Developable 193 nm Photoresist for Green Photolithography (2022)

International audience
Numerical Simulation of GM Refrigerator Operating at about 4 K. (1999)

This paper describes the numerical simulation of a GM refrigerator operating at about 4 K. The simulation model is composed of a regenerator, an expansion space, and a cooling stage. The volumetric change of the expansion space and the actual thermophysical properties of the working fluid, helium are considered. The basic equations are mode up of one-dimensional fluid equations and an energy equation of the regenerator material and the cooling stage. The fluid equations are expressed in the general coordinate system of which a coordinate axis moves with time to take account of the volumetric change of the expansion space. These basic equations are differentiated by using the TVD MacCormack method. In order to verify the simulation model, the theoretical validity of the calculation results was checked and calculation results were compared with results of experiments. As a result it was confirmed that the simulation model is appropriate.
Frequency-flexible stochastic Gabor filter (2015)

This paper introduces an algorithm of a frequency flexible Gabor filter based on stochastic computation. The stochastic Gabor filter provides area-efficient hardware implementation compared to a traditional implementation, but a spacial frequency of the stochastic Gabor filter is restricted by the number of states in an up-down counter used in hardware. In the proposed algorithm, a frequency is determined by two parameters: the number of states and a scaling factor to an input signal. As the input-signal range is scaled down from a stochastic-signal range of [-1:1], a tentative frequency determined by the number of states is precisely controlled to synthesize a flexible frequency desired. The proposed stochastic Gabor filter is modelled and simulated in MATLAB that demonstrates a flexible frequency is synthesized, unlike the conventional method.
Terminology for Policy-Based Management (2001)

This document is a glossary of policy-related terms. It provides abbreviations, explanations
Different cell kinetic changes in rat stomach cancer after treatment with celecoxib or indomethacin: Implications on chemoprevention (2005)

Our findings suggest that the difference in chemopreventive effects of indomethacin and celecoxib in this animal model of gastric carcinogenesis is largely due to the differential cell kinetic changes, which does not correlate with the degree of COX-2 and PG suppression.
APPROCHER LES DEUX INFINIS PAR LES ONDES ELECTROMAGNETIQUES LES STRUCTURES GÉOMÉTRIQUES ÉLÉMENTAIRES DE L'INFORMATION DIGITALE ÉLECTROMAGNÉTIQUE Caractérisation statistique de la mesure digitale des fluctuations spatio-Doppler et polarimétrique de l'onde électromagnétique radar (2019)

Il s'agit de décrire de nouvelles approches géométriques pour définir les statistiques de mesures spatio-temporelles et polarimétrique des états d'une onde électromagnétique, en utilisant les travaux de Maurice Fréchet, Jean-Louis Koszul et Jean-Marie Souriau, avec en particulier la notion d'état « moyen » de cette mesure digitale comme barycentre de Fréchet dans un espace métrique et un modèle issu de la mécanique statistique pour définir et calculer une densité à maximum d'entropie (extension de la notion de gaussienne) pour décrire les fluctuations de l'onde électromagnétique. L'article illustrera ces outils nouveaux avec des exemples d'application en radar pour la mesure Doppler, spatio-temporelle et polarimétrique de l'onde électromagnétique en introduisant une distance sur les matrices de covariance du signal digital électromagnétique, basé sur la métrique de Fisher issue de la Géométrie de l'Information.
Spectroscopic evidence of low-energy gaps persisting up to 120 K in surface-dopedp-terphenyl crystals (2019)

Using high-resolution photoemission spectroscopy on in situ potassium surface-doped para-terphenyl crystals, we uncover a low-energy spectral gap of 12 meV. This spectral gap displays a strong temperature-dependent gap-filling behavior and persists up to 120 K, which is consistent with the onset temperature of a weak steplike diamagnetic transition found in this material. Among a few potential candidates for the origin of the observed gaps, we argue that electron pairing is a plausible origin---a possibility consistent with fluctuating Cooper pairs forming near 120 K.
Nonlinear Predictor-Based Dynamic Resource Allocation Over Point-to-Multipoint (P2MP) Networks: A Control Theoretical Approach (2010)

Most broadband access networks such as passive optical networks (PONs) adopt the point-to-multipoint (P2MP) topology. One critical issue in such networks is the upstream resource management and allocation mechanism. Nonlinear predictor-based dynamic resource allocation (NLPDRA) schemes for improving the P2MP network upstream transmission efficiency have been investigated in an ad hoc manner. In this paper, we establish a general state space model to analyze the controllability and stability of the NLPDRA schemes from the P2MP network system’s point of view and propose controller design guidelines to maintain the system stability under different scenarios. Analytical results show that NLPDRA maintains the P2MP network system controllability even when the loaded network traffic changes drastically. We further prove that a P2MP network system with NLPDRA is stable by proper pole placements as the traffic changes. Finally, we provide guidelines to design a optimal compensator to achieve system accuracy.
18.2: Invited Paper: Semipolar Micro‐LED for Full‐color Display and Visible Light Communication (2021)

Micro‐LEDs (μ‐LEDs) are well known to have a thriving future in the next‐generation display field. However, conventional μ‐LEDs grown on c‐plane GaN have a severe wavelength shift due to the quantum confined Stark effect (QCSE), which seriously affects the color quality of μ‐LEDs display. In order to fundamentally solve this problem, we grown blue μ‐LED with a 30 µm diameter on the (20–21) semipolar GaN combined with perovskite quantum dots (PQDs) color conversion layer, to achieve high‐quality full‐color μ‐LED, realizing a wide color gamut with 99.2% National Television Standards Committee (NTSC) space and 93.0% Rec 2020 in the CIE 1931, and the peak wavelength hardly shifts, indicating an excellent inhibitory on QCSE. Meanwhile, the semipolar blue μ‐LED excitation light can achieve a wide 3‐dB bandwidth of 652 MHz due to the faster carrier recombination rate, making semipolar LEDs more attractive in the high‐speed visible light communication (VLC).
A Highly Sensitive Diketopyrrolopyrrole‐Based Ambipolar Transistor for Selective Detection and Discrimination of Xylene Isomers (2016)

An ambipolar poly(diketopyrrolopyrrole-terthiophene)-based field-effect transistor (FET) sensitively detects xylene isomers at low ppm levels with multiple sensing features. Combined with pattern-recognition algorithms, a sole ambipolar FET sensor, rather than arrays of sensors, can discriminate highly similar xylene structural isomers from one another.
Additional file 9 of Cherenkov luminescence measurements with digital silicon photomultipliers: a feasibility study (2015)

Effect of attenuator, p = 10 %. Effect of the attenuation of the chicken breast placed between source and detector, with the setup shown in Fig. 3 in all dies. Labels and legend follow Fig. 13, and plot positions refer to die positions in the die (Fig. 2-center). (PNG 41 kb)
Analysis of a Multi-Cell Converter under Unbalanced AC Source (2006)

Multi-cell converters offer very useful characteristics for instance, it fulfills the input current harmonic content recommendations and presents a high power factor even at low levels of load at the ac system, and a reduced torque pulsations at the motor side. They also feature a high level of modularity and present a high reliability. Moreover, this converter does not produce electromagnetic interference or common-mode voltages and therefore, it is appropriate for large volt-ampere and high voltage motor drives. Surprising, the analysis under amplitude unbalances at the AC supply has not been reported in the literature. This work shows that the input multi-pulse transformer does not amplify the supply input unbalance. Thus, the secondary voltages feature identical unbalance, which in turn produces unbalanced secondary line currents. Similarly, the overall input currents feature an unbalance which is at most equal to the unbalance of the secondary line currents. It is also found that small voltages unbalances at the input of any cell produce large input line current unbalances. On the other hand, the current injected by the rectifier into the DC link produces a distorted DC voltage waveform, which in turn deteriorates the motor voltage. In this work, using symmetrical components, it is possible to analyze the effect in each of these stages by quantifying the amount of unbalance and distortion produced in the current and voltage waveforms. Besides, this analysis provides a design guideline to compute the DC link capacitor size necessary to reject off the effects of unbalances in the AC supply
Beam steerable quartz integrated lens antenna for 60 GHz frequency band (2011)

This paper presents simulation and experimental investigation results of steerable integrated lens antennas (ILAs) operating in the 60 GHz frequency band. The feed array of the ILAs is comprised by four switched aperture coupled microstrip antenna (ACMA) elements that allows steering between four different antenna main beam directions in one plane. The dielectric lenses of the designed ILAs are extended hemispherical quartz (e = 3.8) lenses with the radiuses of 7.5 and 12.5 mm. The extension lengths of the lenses are selected through the electromagnetic optimization in order to achieve the maximum ILAs directivities and also the minimum directivity degradations of the outer antenna elements in the feed array (± 3 mm displacement) relatively to the inner ones (± 1 mm displacement). Simulated maximum directivities of the boresight beam of the designed ILAs are 19.8 dBi and 23.8 dBi that are sufficient for the steerable antennas for the millimeter-wave WLAN/WPAN communication systems. The feed ACMA array together with the waveguide to microstrip transition dedicated for experimental investigations is fabricated on high frequency and low cost Rogers 4003C substrate. Single Pole Double Through (SPDT) switches from Hittite are used in order to steer the ILA prototypes main beam directions. The experimental results of the fabricated electronically steerable quartz ILA prototypes prove the simulation results and show ±35° and ±22° angle sector coverage for the lenses with the 7.5 and 12.5 mm radiuses respectively.
Liposomal Permeation Assay for Droplet-Scale Pharmacokinetic Screening (2023)

Combinatorial library screening increasingly explores chemical space beyond the Ro5 (bRo5), which is useful for investigating "undruggable" targets but suffers compromised cellular permeability and therefore bioavailability. Moreover, structure-permeation relationships for bRo5 molecules are unclear partially because high-throughput permeation measurement technology for encoded combinatorial libraries is still nascent. Here, we present a permeation assay that is scalable to combinatorial library screening. A liposomal fluorogenic azide probe transduces permeation of alkyne-labeled molecules into small unilamellar vesicles via copper-catalyzed azide-alkyne cycloaddition. Control alkynes (e.g., propargylamine, various alkyne-labeled PEGs) benchmarked the assay. Cell-permeable macrocyclic peptides, exemplary bRo5 molecules, were alkyne labeled and shown to retain permeability. The assay was miniaturized to microfluidic droplets with high assay quality (<i>Z</i>' ≥ 0.5), demonstrating excellent discrimination of photocleaved known membrane-permeable and -impermeable model library beads. Droplet-scale permeation screening will enable pharmacokinetic mapping of bRo5 libraries to build predictive models.
Natural Perspiration Sampling and in Situ Electrochemical Analysis with Hydrogel Micropatches for User-Identifiable and Wireless Chemo/Biosensing (2019)

Recent advances in microelectronics, microfluidics, and electrochemical sensing platforms have enabled the development of an emerging class of fully integrated personal health monitoring devices that exploit sweat to noninvasively access biomarker information. Despite such advances, effective sweat sampling remains a significant challenge for reliable biomarker analysis, with many existing methods requiring active stimulation (e.g., iontophoresis, exercise, heat). Natural perspiration offers a suitable alternative as sweat can be collected with minimal effort on the part of the user. To leverage this phenomenon, we devised a thin hydrogel micropatch (THMP), which simultaneously serves as an interface for sweat sampling and a medium for electrochemical sensing. To characterize the performance of the THMP, caffeine and lactate were selected as two representative target molecules. We demonstrated the suitability of the sampling method to track metabolic patterns, as well as to render sample-to-answer biomarker data for personal monitoring (through coupling with an electrochemical sensing system). To inform its potential application, this biomarker sampling and sensing system is incorporated within a distributed terminal-based sensing network, which uniquely capitalizes on the fingertip as a site for simultaneous biomarker data sampling and user identification.
Fluorescent and Electroactive Low-Viscosity Tetrazine-Based Organic Liquids (2016)

New fluorescent molecular liquids with a tetrazine core have been prepared. These compounds remain liquid at least down to -60 °C and display very low viscosities (28 mPa.s for liquid 1, 58 mPa.s for liquid 2). Both compounds remain fluorescent in the condensed phase. For liquid 1, intermolecular quenching is observed to a certain extent, whereas liquid 2 displays similar photophysical properties in dilute solution and in neat film.
Do Breast Cancer Cell Lines Provide a Relevant Model of the Patient Tumor Methylome? (2014)

It is well documented that tumor cells undergo dramatic genetic and epigenetic changes during initial establishment as cell lines and in subsequent serial passaging, and that the resultant cell lines may have evolved significantly from the primary tumors from which they were derived. This has potential implications due to their widespread use in drug response experiments and studies of genomic function. One approach to optimizing the design of such cell line studies is to identify and use the cell lines that faithfully recapitulate critical features of primary tumors. To evaluate the epigenetic fidelity of breast cancer cell lines in the context of primary tumors, we performed methylation profiling of 55 well-characterized breast cancer cell lines on the Illumina HumanMethylation27 BeadChip platform, and compared them to publicly available methylation profiles of primary breast tumors. We found that the DNA methylation profiles of breast cancer cell lines largely retain the features that characterize primary tumors, although there are crucial differences as well. We describe these similarities and differences between primary tumors and breast cancer cell lines in detail, and develop a quantitative measure of similarity that is used to score each cell line with respect to how faithfully its methylation profile mirrors that of primary tumors.
Structure‐property relationships for a series of amorphous partially aliphatic polyimides (2002)

Abstract High molecular weight, soluble, amorphous, partially aliphatic polyimides were successfully synthesized using an ester acid high‐temperature solution imidization route, which allows one to control desired glass‐transition ( T g ) and processing temperatures. This method involves the prereaction of aromatic dianhydrides with ethanol and a tertiary amine catalyst to form ester acids, followed by the addition of diamines. Subsequent thermal reaction forms fully cyclized polyimides. This reaction pathway eliminates the need for anhydrous solvents and overcomes the problem of salt formation commonly observed for nucleophilic, more‐basic aliphatic amines when utilizing the traditional polyamic acid synthesis route. The molar ratio of aromatic‐to‐aliphatic diamines was varied to generate a series of copolyimides with the chosen dianhydride and tailor the physical properties for specific adhesive applications. This series of copolyimides was characterized by their molecular weight, T g , thermal stability, coefficient of thermal expansion, refractive index, and dielectric constant. Structure‐property relationships were established. The γ and β sub‐ T g viscoelastic properties were researched to understand their molecular origins. © 2002 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 40: 1503–1512, 2002
New Perfluoroalkyl‐Substituted Bisoxazolines as Chiral Ligands in Asymmetric CuII‐Catalyzed Reactions (2004)

Abstract Two new enantiomerically pure perfluoroalkyl‐substituted bisoxazolines (F‐Box) have been prepared by a reaction sequence that involves formation of the properly functionalized Box followed by introduction of one or two n ‐C 8 F 17 residues. These ligands were employed for the first time in the Mukaiyama aldol addition of silylketene thioacetals to methylpyruvate promoted by Cu(OTf) 2 (up to 85% ee ) and in the ene reaction between α‐methylstyrene and ethylglyoxalate in the presence of Cu(OTf) 2 (up to 74% ee ). We compared the reactivities of the new ligands with those of two other chiral fluorous bisoxazolines that we have reported previously. In both cases, the F‐Box that has the lower fluorine content performed better, in terms of chemical yield and enantioselectivity, than the more‐fluorinated one. The recovery and recycling of the ligands is realized either by phase separation of the reaction solvents or by filtration through a short plug of fluorous silica gel. (© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2004)
Optical Limiter using Epsilon-Near-Zero Grating (2019)

Fast optical limiters are needed to protect sensors from intense short laser pulses. An optical limiter design based on a conducting-oxide grating with a large nonlinear refractive index at the plasma frequency is proposed and investigated.
Digital holography microscopy (DHM) operating in pulsed stroboscopic mode: a versatile metrology instrument for micro and nano technology (2007)

Process engineering and failure analysis of MEMS and MOEMS require static and dynamical characterization of both their in-plane and out of plane response to an excitation. A remarkable characteristic of Digital Holography Microscopes (DHM) is the extremely short acquisition time required to grab the whole information necessary to provide 3D optical topography of the sample: a unique frame grab, without any vertical or lateral scan provides the information over the full field of view. First, it ensures DHM measurements to be insensitive to vibrations. Second, it opens the door to fast dynamical characterization of micro-systems. For periodic movement analysis, DHM can operate in two stroboscopic modes with standard cameras. The first one enables precise characterization up to excitation frequencies of 100 kHz with recovery cycle of 10% simply by triggering properly the camera. The second one uses a pulsed source for investigation of higher excitation frequencies. For non periodic movement analysis fast acquisition cameras and postponed treatment are used. DHM are therefore unique and very efficient tool for dynamical characterization of in&hyphen;plane and out-of-plane response. In this paper we illustrate the two stroboscopic modes with an example of a high frequency micro mirror.
Enhanced light extraction efficiency of AlGaN-based deep-ultraviolet light-emitting diodes by utilizing strong sidewall emission (2015)

We demonstrate new design of Deep-UV LEDs extracting strong sidewall-emission redirect top direction. We observe considerably enhanced optical and improved electrical properties and expect this model can provide key idea in current DUV LEDs for enhancing light extraction efficiency.
Supplementary Figure 1 from Nuclear–Cytoplasmic Transport Is a Therapeutic Target in Myelofibrosis (2023)

&lt;p&gt;Supplementary Figure 1&lt;/p&gt;