gebhart/patrepeval huggingface dataset:
Influence of dietary vitamin K intake on subtherapeutic oral anticoagulant therapy (2010)

It is unclear what advice should be given to patients using vitamin K antagonists with respect to dietary vitamin K intake. We performed a nested case-control study in patients attending a Dutch anticoagulation clinic, to determine the association between vitamin K intake and subtherapeutic International Normalized Ratio (INR) values and the interaction between usual and recent vitamin K intake. Compared to patients with a normal usual vitamin K intake, those with a high vitamin K intake had a decreased risk of a subtherapeutic INR [Hazard Ratio (HR) 0.80, 95% confidence interval (CI): 0.56-1.16] and patients with a low vitamin K intake an increased risk (HR 1.33, 95% CI: 0.79-2.25). In patients with a low usual vitamin K intake, recent vitamin K intake was twice as high in cases as in controls (164 vs. 85 microg/d). Such a difference was not observed in patients with a normal or high usual vitamin K intake. Our results suggest that a high vitamin K intake reduces the risk of a low INR by lessening the influence of incidental consumption of vitamin K rich food on the INR. These findings support the recommendation for patients on vitamin K antagonists to eat a sufficient amount of vitamin-K containing foods.
Thermoreversible Cross-Linking of Furan-Containing Ethylene/Vinyl Acetate Rubber with Bismaleimide (2017)

A proof of principle for the use of Diels⁻Alder (DA) chemistry as a thermoreversible cross-linking tool for ethylene⁻vinyl acetate (EVA) rubber is demonstrated using two differently prepared amorphous furan-functionalized EVA rubbers. The first is an EVFM terpolymer of ethylene, vinyl acetate, and furfuryl methacrylate. The second is an EVA-<i>g</i>-furan product, resulting from the reaction of maleated EVA with furfurylamine. Both furan-containing EVA rubbers have been cross-linked with bismaleimide (BM) via a DA coupling reaction to yield final products with similar cross-link density. The BM cross-linked EVFM terpolymer products display rubber properties similar to the ones of peroxide-cured EVA rubbers with similar cross-link densities, whereas the rubber properties of the BM cross-linked EVA-<i>g</i>-furan correspond to those of a rubber with a higher cross-link density. The preparation of the EVA-<i>g</i>-furan was up-scaled to a small internal mixer, which also allowed compounding with carbon black and mineral oil in the same step. Compounding with carbon black results in reinforcement of the EVA rubber (i.e., enhanced strength), and does not interfere with the reprocessing via the retro DA reaction.
Molecular Cytogenetics Guides Massively Parallel Sequencing of a Radiation-Induced Chromosome Translocation in Human Cells (2018)

Chromosome rearrangements are large-scale structural variants that are recognized drivers of oncogenic events in cancers of all types. Cytogenetics allows for their rapid, genome-wide detection, but does not provide gene-level resolution. Massively parallel sequencing (MPS) promises DNA sequence-level characterization of the specific breakpoints involved, but is strongly influenced by bioinformatics filters that affect detection efficiency. We sought to characterize the breakpoint junctions of chromosomal translocations and inversions in the clonal derivatives of human cells exposed to ionizing radiation. Here, we describe the first successful use of DNA paired-end analysis to locate and sequence across the breakpoint junctions of a radiation-induced reciprocal translocation. The analyses employed, with varying degrees of success, several well-known bioinformatics algorithms, a task made difficult by the involvement of repetitive DNA sequences. As for underlying mechanisms, the results of Sanger sequencing suggested that the translocation in question was likely formed via microhomology-mediated non-homologous end joining (mmNHEJ). To our knowledge, this represents the first use of MPS to characterize the breakpoint junctions of a radiation-induced chromosomal translocation in human cells. Curiously, these same approaches were unsuccessful when applied to the analysis of inversions previously identified by directional genomic hybridization (dGH). We conclude that molecular cytogenetics continues to provide critical guidance for structural variant discovery, validation and in "tuning" analysis filters to enable robust breakpoint identification at the base pair level.
Morphofunctional correlations of the forearm muscle at sheep and dog. (2012)

At both ovines and canines, the carpal, metacarpophalangeal and interphalangeal joints are predominantly organized in order for flexion and extension to be possible.cSince these movements are made in the same way for all joints mentioned, extensor muscles are grouped on the back and flexor muscles are on the palmar. At dogs, supinator muscles are framed in terms of topography, in extensor, dorsal muscle group and the pronator muscle in flexor, palmar muscle group.
The human dendritic cell marker CD83 maps to chromosome 6p23 (1999)

The chromosomal localization of the human CD83 gene was determined using somatic cell hybrids, a radiation hybrid mapping panel and FISH analysis on human metaphase chromosomes. PCR-based analysis of a single chromosome hybrid panel identified the presence of the CD83 gene on human chromosome 6 and subsequent analysis of the Genebridge4 radiation panel located the gene between AFMa192wg9 and AFMb322wd1 with a lod score of 9.2. Finally, using FISH analysis the CD83 gene was localized to chromosome 6 band p23.
A Novel Semi-Automated Paramagnetic Microparticle Based Enzyme Immunoassay for Hepatitis C Virus: Its Application to Serologic Testing (1992)

A new rapid serologic enzyme immunoassay for antibodies to hepatitis C virus (HCV) is described. The assay combines synthetic peptide and recombinant antigens representing putative structural and non structural HCV gene products with paramagnetic microparticle assay (MP assay) technology. Assay readout is based upon an enzymatically generated fluorescent product which is quantified with a novel semi-automated washer/reader instrument system. Assay sensitivity and specificity was determined to be greater than the first generation HCV C-100 EIA using a non-A, non-B hepatitis disease panel, an HCV performance panel, an HCV seroconversion panel, dilutions of HCV reactive sera, and random volunteer blood donor specimens.
The inheritance of four mutants in early-flowering Brassica campestris L. (1978)

Four mutants were isolated from S1 progenies of early-flowering B. campestris plants and were described as dwarf plant, tucked petal, jagged petal margin, and male sterile. All were inherited as monogenic recessives. Genetic concepts that can be demonstrated by using these mutants include segregation. pleiotropy, penetrance, expressivity, and epistasis.
Supplementary Figure and Table Legends from Spliced Peptides and Cytokine-Driven Changes in the Immunopeptidome of Melanoma (2023)

&lt;p&gt;Supplementary figure legends and tables descriptors&lt;/p&gt;
Detection and quantitation of human papillomavirus DNA in the plasma of patients with cervical carcinoma. (2002)

Human papillomaviruses (HPVs) play a central role in the development of cervical carcinoma. Plasma DNA from 232 patients taken at diagnosis or after treatment for invasive cervical cancer (n = 175) or carcinoma in situ (n = 57) and 60 normal controls were examined for HPV-16 or HPV-18 E7 DNA by conventional and real-time quantitative PCR assays. We found HPV-16 or HPV-18 E7 DNA in 6.9% (11 of 175) of invasive cervical cancer cases (18.1% of cases positive for HPV-16 or HPV-18 at the genital tract), 1.8% (1 of 57) of carcinoma in situ, and 1.7% (1 of 60) of normal controls by conventional PCR. Quantitative PCR identified the highest concentrations of HPV DNA (copy number of HPV/ml of plasma) in patients with invasive cervical cancer (mean, 11,163; median, 183.5), followed by a level of 8 in the single carcinoma in situ case and 0 copies in the normal control initially positive by conventional PCR. HPV DNA can be detected in the plasma of some patients with HPV-positive cervical tumors. It remains to be demonstrated whether quantitative PCR analysis of HPV DNA in plasma may have utility in patients at high risk of recurrent disease.
Active pitch control of tethered wings for airborne wind energy (2014)

A study on the aerodynamics and on the active pitch control of curved tethered wings for airborne wind energy is presented. Computational fluid dynamics techniques, previously validated with experimental data, are used to derive the aerodynamic coefficients of a curved kite as a function of the angle of attack. In contrast with previous results, such analysis indicates that the kite efficiency is quite flat over a wide range of values of the angle of attack. Based on such analysis, an active pitch control strategy is proposed, which is able to maximize the generated traction force during operation without requiring neither an estimate of the angle of attack, nor an accurate model of the system's dynamics.
Preface (2009)

ADVERTISEMENT RETURN TO BOOKPREVPrefaceNEXTPrefaceR. NagarajanR. NagarajanMolecular Sciences and Engineering Team Natick Soldier Research, Development & Engineering Center Natick, MAMore by R. Nagarajan, Walter ZukasWalter ZukasChemical Technology Team Natick Soldier Research, Development & Engineering Center Natick, MAMore by Walter Zukas, T. Alan HattonT. Alan HattonDepartment of Chemical Engineering Massachusetts Institute of Technology Cambridge, MAMore by T. Alan Hatton, and Stephen LeeStephen LeeU.S. Army Research Office Research Triangle Park, NCMore by Stephen LeeDOI: 10.1021/bk-2009-1016.pr001 This publication is free to access through this site. Learn MorePublication Date (Web):December 11, 2009Publication History Published online11 December 2009Published inprint 24 December 2009Request reuse permissions Copyright © 2009 American Chemical Society. This publication is available under these Terms of Use. Nanoscience and Nanotechnology for Chemical and Biological Defensepp xi-xivACS Symposium SeriesVol. 1016ISBN13: 9780841269811eISBN: 9780841225213Chapter Views750Citations-LEARN ABOUT THESE METRICSChapter Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (151 KB) Get e-Alerts
Advantages at network level of contentionless N×M adWSS (2019)

When connected to bundle of transponders, 8×24 adWSS can insert/extract more traffic than 8×32 MCS in contentionless OXCs. We quantify this advantage for an Indian core WDM elastic networks transporting 75 GHz-spaced 64 GBaud carriers.
Deposition of Hydrogenated Si Clusters on Si(111)-(7×7)Surfaces (1998)

We have studied surface structures arising from the deposition of stable hydrogenated Si cluster ions, ${\mathrm{Si}}_{6}{\mathrm{H}}_{13}^{+}$ on $\mathrm{Si}(111)\ensuremath{-}(7\ifmmode\times\else\texttimes\fi{}7)$, using scanning tunneling microscopy. The ${\mathrm{Si}}_{6}{\mathrm{H}}_{13}^{+}$ clusters, which have a ring structure with ${\mathrm{sp}}^{3}$ bonding, have been deposited on Si(111) with a deposition energy of 18 eV at room temperature. The clusters preferentially adsorbed at the lower terrace of the steps. Few clusters were observed on the flat surfaces, showing that the cluster is mobile on the surface due to its weak interaction with Si(111). Hexagonal-type ordering with the $(\sqrt{7}\ifmmode\times\else\texttimes\fi{}\sqrt{7})R\ifmmode\pm\else\textpm\fi{}19.1\ifmmode^\circ\else\textdegree\fi{}$ configuration consisting of ${\mathrm{Si}}_{6}{\mathrm{H}}_{12}$, which was converted from ${\mathrm{Si}}_{6}{\mathrm{H}}_{13}^{+}$ after landing, was observed partially.
The Development of Delivery Agents that Facilitate the Oral Absorption of Macromolecular Drugs (2000)

Macromolecules comprise a growing group of new drugs with great clinical promise. To date, the therapeutic application of these drugs has been limited, because they are effective only when administered parenterally. Unfortunately, macromolecular drugs are not absorbed following nonparenteral dosing, because the mechanisms of the human body are designed to degrade and/or exclude them. To overcome the numerous obstacles to the noninvasive delivery of these drugs, various approaches are under investigation including the use of delivery agents to promote drug absorption. This review provides a summary of the novel approaches currently in progress in the areas of transdermal, transmucosal, and oral delivery of macromolecular drugs facilitated by delivery agents. We review our own novel work in this area in some detail, including the methods developed for the synthesis of the delivery agents, in vitro screening techniques developed to select compounds for in vivo testing, and the results of in vivo screening in both rats and primates, including preliminary safety and efficacy studies. Finally, the results of Phase I clinical studies showing the oral delivery of heparin are presented.
Expanding the indication spectrum: renal denervation in diabetes (2013)

Catheter-based renal denervation (RDN) has been shown to reduce sympathetic nerve activity and blood pressure in patients with resistant hypertension. Increased central sympathetic activity is a main contributor to the pathophysiology of several important chronic cardiovascular diseases, including diabetes and the metabolic syndrome. Indeed several recently published pilot studies and case reports suggest beneficial effects of RDN on glucose metabolism in patients with resistant hypertension. This review highlights the background of approaching the renal sympathetic nerves as a potential new therapeutic option to improve glycaemic control in patients with resistant hypertension.
Designed, Folded Polypeptide Scaffolds That Combine Key Biosensing Events of Recognition and Reporting (2002)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTDesigned, Folded Polypeptide Scaffolds That Combine Key Biosensing Events of Recognition and ReportingKarin Enander, Gunnar T. Dolphin, Linda K. Andersson, Bo Liedberg, Ingemar Lundström, and Lars BaltzerView Author Information Department of Chemistry-IFM and Department of Applied Physics-IFM, Linköping University, 581 83 Linköping, Sweden, and Department of Organic Chemistry, Göteborg University, 412 96 Göteborg, Sweden [email protected].Cite this: J. Org. Chem. 2002, 67, 9, 3120–3123Publication Date (Web):April 2, 2002Publication History Received26 September 2001Published online2 April 2002Published inissue 1 May 2002https://pubs.acs.org/doi/10.1021/jo010954nhttps://doi.org/10.1021/jo010954nbrief-reportACS PublicationsCopyright © 2002 American Chemical SocietyRequest reuse permissionsArticle Views324Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Biosensing,Fluorescence,Ligands,Monomers,Peptides and proteins Get e-Alerts
Correlating military operators' visual demands with multi-spectral image fusion (2008)

Multi-spectral image portrayal using several sensors is a revolutionary way to increase the amount of useful visual information to the end user. However, for maximum usability, the information from multiple sensors must be fused into a single image that can be understood. The decisions about which sensors are delivering the most important information for a given viewing situation and what manipulations should be done to the acquired data are complex. To better examine this complexity, information was obtained from aviators about which visual tasks are deemed to be most important. This information was gathered from discussions with pilots and other aircrew members as well as from relevant publications. The important visual task information was then used to develop a matrix that included specific visual aspects of the task (e.g., detection or identification). The matrix also included other parameters that could affect or alter the ability to "see" the desired target or perform the task. These other parameters include ambient lighting, environmental conditions (e.g., clear or hazy atmospheres), man-made impediments to vision (camouflage or smoke), and which image enhancing algorithms should be applied (e.g., contrast enhancement or noise reduction). This top-down evaluation was then used to determine which image enhancement algorithms are most important and which will be employed most often for the identified visual tasks.
Experiences with BOWL: managing an outdoor WiFi network (or how to keep both internet users and researchers happy?) (2011)

The Berlin Open Wireless Lab (BOWL) project at Technische Universitt Berlin (TUB) maintains an outdoor WiFi network which is used both for Internet access and as a testbed for wireless research.From the very beginning of the BOWL project, we experienced several development and operations challenges to keep Internet users and researchers happy.Development challenges included allowing multiple researchers with very different requirements to run experiments in the network while maintaining reliable Internet access.On the operations side, one of the recent issues we faced was authentication of users from different domains, which required us to integrate with various external authentication services.In this paper, we present our experience in handling these challenges on both development and operations sides and the lessons we learned.
Differenzreflektometrie an NiAl- und CoGa-Legierungen nach einer Belichtung mit intensiver UV-Strahlung / Differential Reflectometry of NiAl and CoGa Alloys Subsequent to an Exposure to Intensive UV Radiation (1990)

Article Differenzreflektometrie an NiAl- und CoGa-Legierungen nach einer Belichtung mit intensiver UV-Strahlung / Differential Reflectometry of NiAl and CoGa Alloys Subsequent to an Exposure to Intensive UV Radiation was published on October 1, 1990 in the journal International Journal of Materials Research (volume 81, issue 10).
Fluorine–Protein Interactions and 19F NMR Isotropic Chemical Shifts: An Empirical Correlation with Implications for Drug Design (2010)

An empirical correlation between the fluorine isotropic chemical shifts, measured by ¹⁹F NMR spectroscopy, and the type of fluorine-protein interactions observed in crystal structures is presented. The CF, CF₂, and CF₃ groups present in fluorinated ligands found in the Protein Data Bank were classified according to their ¹⁹F NMR chemical shifts and their close intermolecular contacts with the protein atoms. Shielded fluorine atoms, i.e., those with increased electron density, are observed primarily in close contact to hydrogen bond donors within the protein structure, suggesting the possibility of intermolecular hydrogen bond formation. Deshielded fluorines are predominantly found in close contact with hydrophobic side chains and with the carbon of carbonyl groups of the protein backbone. Correlation between the ¹⁹F NMR chemical shift and hydrogen bond distance, both derived experimentally and computed through quantum chemical methods, is also presented. The proposed "rule of shielding" provides some insight into and guidelines for the judicious selection of appropriate fluorinated moieties to be inserted into a molecule for making the most favorable interactions with the receptor.
Self-Aligned N-Polar GaN/InAlN MIS-HEMTs With Record Extrinsic Transconductance of 1105 mS/mm (2012)

In this letter, we demonstrate state-of-the-art performance from N-polar GaN/InAlN metal-insulator-semiconductor high-electron mobility transistors (MIS-HEMTs). Self-aligned gate-first process was used for the fabrication of transistors. Graded InGaN and InN contact layers were used to achieve a low ohmic contact resistance of 25 Ω · μm. Excellent dc performance with the highest extrinsic g <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m</sub> of 1105 mS/mm, lowest R <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">on</sub> of 0.29 Ω · mm, and maximum current of 2.77 A/mm was achieved for L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">g</sub> = 60 nm. The dc performance was found to scale well with the gate length. The highest f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> of 155 GHz was obtained for L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">g</sub> = 30 nm.
Supplementary Table 12 from Cancer-Associated Fibroblasts Promote Aggressive Gastric Cancer Phenotypes via Heat Shock Factor 1–Mediated Secretion of Extracellular Vesicles (2023)

&lt;p&gt;Univariate and multivariate analysis of the gastric cancer patient cohort&lt;/p&gt;
Joint linear and non-linear adaptive pre-distortion of high baud rate transmitters for high-order modulation formats (2016)

We review a digital pre-distortion technique to mitigate linear and nonlinear impairments from analog components. We assess the technique's effectiveness and accuracy for high baud rate signals and high-order modulation formats.
Is achieving optimal spinopelvic parameters necessary to obtain substantial clinical benefit? An analysis of patients who underwent circumferential minimally invasive surgery or hybrid surgery with open posterior instrumentation (2019)

Achieving optimal spinopelvic parameters was not a predictor for achieving an MCID or SCB. Since spinopelvic parameters are correlated with clinical outcomes, the authors' findings suggest that the presently accepted optimal spinopelvic parameters may require modification. Other factors, such as improvement in neurological symptoms and/or segmental instability, also likely impacted the clinical outcomes.
Supplementary Figure Legends 1-7 from <i>miR-152</i> Is a Tumor Suppressor microRNA That Is Silenced by DNA Hypermethylation in Endometrial Cancer (2023)

&lt;p&gt;PDF file - 111K&lt;/p&gt;