gebhart/patrepeval huggingface dataset:
Spatio-Temporal Processing in Wireless Communications (1999)

Herein, we provide an overview of the research conducted in the project &amp;quot;Spatio-Temporal Processing in Wireless Communications&amp;quot; supported by NUTEK&amp;apos;s telecommunications program. Spatio-temporal processing at the base stations of a wireless system can provide processing gain which may be used to extend range and improve coverage of the network and/or improve signal quality and lower terminal power requirements. Furthermore, with spatially selective reception and transmission, the capacity in wireless communication systems can be increased without exploiting additional bandwidth. We will give an overview of the results of this research project to date. 1 Introduction There is considerable interest today in finding cost efficiently ways to increase the spectral efficiency and range of wireless networks. One method of achieving this goal is to exploit the spatial dimension in the network. Current wireless systems use the spatial dimension in a rudimentary way by using a given frequency cha...
Kinetics of Interleukin-1 and Tumor Necrosis Factor Secretion by Rabbit Macrophages Recovered from the Peritoneal Cavity after Surgery (1991)

Macrophages play a crucial role in wound healing after surgical injury, both as scavenger cells responsible for wound debridement and as cells that secrete soluble factors such as interleukin-1 (IL-1) and tumor necrosis factor (TNF). IL-1 and TNF alter many of the biological activities of cells that appear in postsurgical wounds. In this study, we determined the kinetics of IL-1 and TNF production by rabbit macrophages harvested from postsurgical peritoneal exudate (postsurgical macrophages) at several time points after peritoneal surgery. To further characterize the level of functional activities of postsurgical macrophages, the IL-1 and TNF levels were determined with or without stimulating the cells with lipopolysaccharide (LPS) and phorbol myristate acetate (PMA). After surgery, the number of macrophages harvested by peritoneal lavage increased, reached peak levels on postsurgical day 3, and then decreased. IL-1 levels secreted by macrophages cultured without stimuli were elevated on postsurgical day 14 compared to the values on day 3 and 7. TNF concentrations peaked on days 1 and 14. In the conditioned culture media from LPS-PMA-stimulated macrophages, the levels of both IL-1 and TNF peaked on postsurgical days 3 and 14. These data suggest that the susceptibility of postsurgical macrophages to stimuli changes during the wound healing process with maximum sensitivity to the stimuli present during the early phase of peritoneal repair (day 3).
Modulation of Macrophage Activity in Tumor Bearing Mice by Cytogenin. (1995)

Cytogenin recovered the reduced mitogenic response to Con A of spleen cells of tumor bearing mice in vitro. The suppressive factor(s) was detected in adherent cell population in spleen cells. The reduced antitumor effector activity of spleen cells taken from tumor bearing mice was also augmented by the treatment with cytogenin in vitro. The effect of cytogenin was neutralized by the treatment with anti-Mac 1 serum. Administration of cytogenin inhibited the production of nitric oxide by macrophages which is known as one of suppressor factors. Results indicate that one possible action of cytogenin exhibiting antitumor activity in tumor bearing mice may be due to modulation of Mac 1 positive cells.
Self-assembly of a hydrogen-bonded 2 + 3 supramolecular complex (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSelf-assembly of a hydrogen-bonded 2 + 3 supramolecular complexChristopher T. Seto and George M. WhitesidesCite this: J. Am. Chem. Soc. 1991, 113, 2, 712–713Publication Date (Print):January 1, 1991Publication History Published online1 May 2002Published inissue 1 January 1991https://pubs.acs.org/doi/10.1021/ja00002a071https://doi.org/10.1021/ja00002a071research-articleACS PublicationsRequest reuse permissionsArticle Views451Altmetric-Citations102LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Table S5. Methylation ratio at each CpG for all samples from Targeted, Deep Sequencing Reveals Full Methylation Profiles of Multiple HPV Types and Potential Biomarkers for Cervical Cancer Progression (2023)

&lt;p&gt;Each sample is listed with methylation ratios at each CpG in the corresponding HPV genome.&lt;/p&gt;
Efficacy and safety of dupilumab with concomitant topical corticosteroids in children 6 to 11 years old with severe atopic dermatitis: A randomized, double-blinded, placebo-controlled phase 3 trial (2020)

Dupilumab + TCS is efficacious and well tolerated in children with severe AD, significantly improving signs, symptoms, and QOL.
Interface and bulk effects for bias—light‐illumination instability in amorphous‐In—Ga—Zn—O thin‐film transistors (2010)

Abstract— Positive‐current‐bias (PB) instability and negative‐bias—light‐illumination (NBL) instability in amorphous‐In—Ga—Zn—O (a‐IGZO) thin‐film transistors (TFTs) have been examined. The channel‐ thickness dependence indicated that the V th instability caused by the PB stress is primarily attributed to defects in the bulk a‐IGZO region for unannealed TFTs and to those in the channel—gate‐insulator interface for wet‐annealed TFTs. The interface and bulk defect densities ( Dit and Nss , respectively) are Dit = 4.8 × 10 11 cm −2 /eV and Nss = 7.0×10 16 cm −3 /eV for the unannealed TFT, which increased to 5.2×10 11 cm −2 /eV and 9.8×10 16 cm −3 /eV, respectively, by the PB stress test. These are reduced significantly to Dit = 0.82×10 11 cm −2 /eV and Nss = 3.2×10 16 cm −3 /eV for the wet‐annealed TFTs and are unchanged by the PB stress test. It was also found that the photo‐response of a‐IGZO TFTs begins at 2.3 eV of photon excitation, which corresponds to subgap states observed by photoemission spectroscopy. The origin of the NBL instability for the wet‐annealed TFTs is attributed to interface effects and considered to be a trap of holes at the channel‐gate—insulator interface where migration of the holes is enhanced by the electric field formed by the negative gate bias.
Circuit synthesis of clock distribution networks based on non-zero clock skew (2002)

A methodology is presented in this paper for synthesizing clock distribution networks by inserting circuit structures to emulate the delay values assigned to specified branches of the clock tree. These clock distribution networks are designed with localized non-zero clock skew so as to improve circuit performance and reliability. The design methodology is targeted for CMOS technology. The clock lines are transformed from distributed resistive-capacitive interconnect lines into purely capacitive interconnect lines by partitioning the RC interconnect lines with inverting repeaters. The inverters are specified by the geometric size of the transistors, the slope of the ramp shaped input/output waveform, and the output load capacitance. The branch delay model integrates both an inverter delay model and an interconnect delay model. Maximum errors of less than 3% for the delay of the clock paths and 6% for the clock skew between any two registers belonging to the same global data path are obtained as compared to SPICE Level-3.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Low Rate Coded Interleave Division Multiple Access on Rician Fading Channels (2007)

The performance of Interleave Division Multiple Access (IDMA) with a new set of low rate turbo codes is evaluated on Additive White Gaussian Noise (AWGN) and Rician fading channels. Despite the simplicity of the scheme and excessive multiuser interference, very good performance close to theoretical limit is demonstrated. The effect of varying number of users, code rate and channel characteristics on the performance is investigated.
Abstract LB-053: VPS4A is a synthetic lethal target in VPS4B-deficient cancers due to co-deletion with SMAD4 (2020)

Abstract Somatic copy number alterations that result in loss of tumor suppressor gene function are important drivers of tumorigenesis. However, few existing therapeutic options to target oncogenic processes evoked by tumor suppressor gene inactivation exist. The discovery of synthetic lethal interactions with genetic drivers of cancer may yield new therapeutic strategies with cancer selective potential. We examined genome-scale CRISPR-SpCas9 and RNA interference screens to uncover new synthetic lethal vulnerabilities associated with the loss of common tumor suppressor genes (TSGs). Vacuolar protein sorting 4 homolog A (VPS4A) scored as a strong, selective dependency in cancer cells with genomic loss of the SMAD4 tumor suppressor due to co-deletion of VPS4A's paralog gene, VPS4B. VPS4B resides 12.3 Mb away from the SMAD4 TSG on chromosome 18q and is lost in approximately 33% of all cancers, suggesting broad clinical applicability. VPS4A and VPS4B function as AAA ATPases forming a multimeric protein complex within the endosomal sorting complex required for transport (ESCRT) pathway to regulate membrane remodeling in a range of cellular processes. VPS4A suppression in cells with VPS4B/SMAD4 loss led to accumulation of ESCRT-III filaments, cytokinesis defects, nuclear deformation and micronucleation, which ultimately resulted in G2/M cell cycle arrest and apoptosis. Furthermore, upon VPS4A suppression, we observerd potent in vivo tumor regression, which led to extended survival, in mouse subcutaneous xenograft models with human cancer cell lines harboring VPS4B loss. Finally, genome-scale CRISPR-SpCas9 loss-of-function screening revealed other ESCRT pathway members and regulators of cellular abscission as modifiers of VPS4A dependency. Using the most comprehensive available CRISPR-SpCas9 and RNA-interference screening datasets to date, we provide a compendium of synthetic lethal vulnerabilities with TSG loss and credential VPS4A as a new and promising therapeutic target in cancers with VPS4B/SMAD4 deletion. Citation Format: Jasper E. Neggers, Brenton R. Paolella, Adhana Asfaw, Michael V. Rothberg, Thomas A. Skipper, Radha L. Kalekar, John M. Krill-Burger, Andrew L. Hong, Guillaume Kugener, Jeremie Kalfon, Annan Yang, Chen Yuan, Nancy Dumont, Alfredo Gonzalez, Mai Abdusamad, Yvonne Y. Li, Liam F. Spurr, Westley W. Wu, Federica Piccioni, Brian M. Wolpin, David E. Root, Jesse S. Boehm, Andrew D. Cherniack, Aviad Tsherniak, Todd R. Golub, Francisca Vazquez, Andrew J. Aguirre. VPS4A is a synthetic lethal target in VPS4B-deficient cancers due to co-deletion with SMAD4 [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr LB-053.
CXCR4 as a novel target in immunology: moving away from typical antagonists (2022)

CXCR4 has been a target of interest in drug discovery for numerous years. However, so far, most if not all studies focused on finding antagonists of CXCR4 function. Recent studies demonstrate that targeting a minor allosteric pocket of CXCR4 induces an immunomodulating effect in immune cells expressing CXCR4, connected to the TLR pathway. Compounds binding in this minor pocket seem to be functionally selective with inverse agonistic properties in selected GPCR signaling pathways (G<sub>i</sub> activation), but additional signaling pathways are likely to be involved in the immunomodulating effects. In depth research into these CXCR4-targeted immunomodulators could lead to novel treatment options for (auto)-immune diseases.
CD28-independent Costimulation of T Cells in Alloimmune Responses (2001)

T cell costimulation by B7 molecules plays an important role in the regulation of alloimmune responses. Although both B7-1 and B7-2 bind CD28 and CTLA-4 on T cells, the role of B7-1 and B7-2 signaling through CTLA-4 in regulating alloimmune responses is incompletely understood. To address this question, we transplanted CD28-deficient mice with fully allogeneic vascularized cardiac allografts and studied the effect of selective blockade of B7-1 or B7-2. These mice reject their grafts by a mechanism that involves both CD4(+) and CD8(+) T cells. Blockade of CTLA-4 or B7-1 significantly accelerated graft rejection. In contrast, B7-2 blockade significantly prolonged allograft survival and, unexpectedly, reversed the acceleration of graft rejection caused by CTLA-4 blockade. Furthermore, B7-2 blockade prolonged graft survival in recipients that were both CD28 and CTLA-4 deficient. Our data indicate that B7-1 is the dominant ligand for CTLA-4-mediated down-regulation of alloimmune responses in vivo and suggest that B7-2 has an additional receptor other than CD28 and CTLA-4 to provide a positive costimulatory signal for T cells.
Reactions of Tin(IV) Enolates and Radicals Derived from the Tin Hydride Scission of Cyclopropyl Ketones (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTReactions of Tin(IV) Enolates and Radicals Derived from the Tin Hydride Scission of Cyclopropyl KetonesEric J. Enholm and Zhaozhong J. JiaView Author Information Department of Chemistry, University of Florida, Gainesville, Florida 32611Cite this: J. Org. Chem. 1997, 62, 16, 5248–5249Publication Date (Web):August 8, 1997Publication History Received23 May 1997Published online8 August 1997Published inissue 1 August 1997https://pubs.acs.org/doi/10.1021/jo970914chttps://doi.org/10.1021/jo970914crapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views402Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Aldol reactions,Bond cleavage,Chemical reactions,Enolates,Ketones Get e-Alerts
Phase Consistent Ecological Domain Adaptation (2020)

We introduce two criteria to regularize the optimization involved in learning a classifier in a domain where no annotated data are available, leveraging annotated data in a different domain, a problem known as unsupervised domain adaptation. We focus on the task of semantic segmentation, where annotated synthetic data are aplenty, but annotating real data is laborious. The first criterion, inspired by visual psychophysics, is that the map between the two image domains be phase-preserving. This restricts the set of possible learned maps, while enabling enough flexibility to transfer semantic information. The second criterion aims to leverage ecological statistics, or regularities in the scene which are manifest in any image of it, regardless of the characteristics of the illuminant or the imaging sensor. It is implemented using a deep neural network that scores the likelihood of each possible segmentation given a single un-annotated image. Incorporating these two priors in a standard domain adaptation framework improves performance across the board in the most common unsupervised domain adaptation benchmarks for semantic segmentation.
Mechanically Flexible Interconnects and TSVs (2017)

A through-silicon via (TSV) generally consists of a metal conductor in vertical direction through silicon and thin dielectric liner between the metal and the silicon. Various materials such as copper, tungsten, nickel, and aluminum can be used as metal in TSVs. Copper is mostly used for the TSV metal part because of the ease of fabricating high-aspect ratio TSVs in chips as well as in silicon interposer packages using electroplating, better electromigration resistance, and comparatively lower resistivity. Large-diameter TSVs that result due to the thick chips create a fabrication challenge. The mechanical characteristics of the flexible I/O for microelectromechanical system (MEMS) integration required were very different and a new flexible I/O technology was needed. The steady growth of the MEMS industry has been nothing short of incredible. However, three-dimensional integration of complementary metal–oxide-semiconductor and MEMS has potential to do more than just addressing the problems of conventional integration methods—it can provide new features.
Data from MI130004, a Novel Antibody–Drug Conjugate Combining Trastuzumab with a Molecule of Marine Origin, Shows Outstanding <i>In Vivo</i> Activity against HER2-Expressing Tumors (2023)

&lt;div&gt;Abstract&lt;p&gt;In the search for novel payloads to design new antibody–drug conjugates (ADC), marine compounds represent an interesting opportunity given their unique chemical features. PM050489 is a marine compound that binds β-tubulin at a new site and disrupts the microtubule network, hence leading to mitotic aberrations and cell death. PM050489 has been conjugated to trastuzumab via Cys residues through a noncleavable linker, and the resulting ADC, named MI130004, has been studied. Analysis of MI130004 delivered data consistent with the presence of two molecules of PM050489 per antibody molecule, likely bound to both sides of the intermolecular disulfide bond connecting the antibody light and heavy chains. The antitumor activity of MI130004 was analyzed &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt; in different cell lines of diverse tumor origin (breast, ovary, and gastric cancer) expressing different levels of HER2. MI130004 showed very high &lt;i&gt;in vitro&lt;/i&gt; potency and good selectivity for tumor cells that overexpressed HER2. At the cellular level, MI130004 impaired tubulin polymerization, causing disorganization and disintegration of the microtubule network, which ultimately led to mitotic failure, mirroring the effect of its payload. Treatment with MI130004 in mice carrying histologically diverse tumors expressing HER2 induced a long-lasting antitumor effect with statistically significant inhibition of tumor growth coupled with increases in median survival time compared with vehicle or trastuzumab. These results strongly suggest that MI130004 is endowed with remarkable anticancer activity and confirm the extraordinary potential of marine compounds for the design of new ADCs. &lt;i&gt;Mol Cancer Ther; 17(4); 786–94. ©2018 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Doxycycline-Mediated Inhibition of Matrix Metalloproteinases Improves Healing after Rotator Cuff Repair (2009)

Background Recent studies demonstrate a potentially critical role of matrix metalloproteinases (MMPs) and their inhibitors in the pathophysiology of rotator cuff tears. Hypothesis Doxycycline-mediated MMP inhibition after rotator cuff repair will improve tendon-to-bone healing. Study Design Controlled laboratory study. Methods Rats (n = 183) underwent acute detachment and repair of the supraspinatus tendon and the animals were divided into 4 groups: In controls (n = 66), the supraspinatus was repaired to its anatomical footprint. In experimental groups, an identical surgery was performed with doxycycline (130 mg/kg/d) administered orally at (1) preoperative day 1 (n = 66), (2) postoperative day (POD) 5 (n = 28), or (3) POD 14 (n = 23). Animals were sacrificed at 5 days, 8 days, 2 weeks, and 4 weeks. Tendon-bone interface was evaluated with histomorphometry. Enzyme-linked immunosorbent assay for local MMP-13 activity was performed at 8 days and 4 weeks. Biomechanical testing of the healing enthesis was performed at 8 days, 2 weeks, and 4 weeks. Serum doxycycline levels were measured at sacrifice. Statistical analysis was performed using unpaired t tests and 2-way analysis of variance (P &lt; .05). Results Serum doxycycline levels were significantly higher in all treated groups compared with controls (1830 ± 835 vs 3 ± 3 ng/mL, respectively; P &lt; .001). Doxycycline-treated animals demonstrated greater metachromasia and improved collagen organization at the healing enthesis at POD 5 (P &lt; .06), POD 8 (P &lt; .03), and 2 weeks (P &lt; .04). The MMP-13 activity was significantly reduced in doxycycline-treated compared with control animals at POD 8 (6740 ± 2770 vs 10400 ± 2930 relative fluorescent units [RFU], respectively; P &lt; .02) but not at 4 weeks (3600 ± 3280 vs 4530 ± 2720 RFU, respectively). The healing enthesis of animals started on doxycycline preoperatively or at POD 5 had an increased load to failure compared to controls at 2 weeks (13.6 ± 1.8 and 13.2 ± 1.94 N vs 9.1 ± 2.5 N, respectively; P &lt; .01). Conclusion/Clinical Relevance Modulation of MMP-13 activity after rotator cuff repair may offer a novel biological pathway to augment tendon-to-bone healing.
Design and fabrication strategy in the world of functional gradation (2010)

The concept of Functionally Graded Materials, FGM, was introduced in 1980s for the development of reliable thermal shock resistant components for high temperature applications. Later on biomimetic approaches were included, to arrive at multifunctional, multiscale FGM's for numerous applications, including abrasion resistant materials and materials for implants. The paper briefly reviews the past achievements and highlights future trends in multi-scale graded materials science and technology, with the aim at utilisation of bio-inspired methods in design and fabrication strategy. Examples are given for systems with hierarchically graded porosity for application in hard tissue implants and in diesel engine filters, respectively.
The Role of CGRP in the Development of Morphine Tolerance and Physical Dependence (2001)

This article has no abstract.
The diversity of MMSE receiver over frequency-selective MIMO channel (2011)

This paper analyzes the MMSE receiver in MIMO frequency-selective channels. This expands our understanding of the MMSE MIMO channel, whose diversity was only recently characterized in the MIMO flat-fading regime. Specifically, in this paper lower and upper bounds on the diversity of the MMSE receiver operating over frequency selective MIMO channel under block transmission with zero-padding (ZP) or cyclic-prefix (CP) are produced. The tightness of the bounds is demonstrated for both ZP/CP for the special case of SIMO channel.