gebhart/patrepeval huggingface dataset:
Low-cost active electrode improves the resolution in biopotential recordings (2002)

The accepted models of the origin of interference in body surface potential recordings predict that it would be advantageous to perform signal amplification on the electrode. A suitable circuit for a miniature biopotential amplifier to be manufactured in thick-film technology is described. A prototype series of active electrodes was produced and tested. The high immunity to interference resulted in ECG and EEG recordings of a very high quality.
ChemInform Abstract: Reactions of Arylhydroxylamines and Related Compounds with Benzene. (1977)

Abstract Durch intramolekulare N‐Oxid‐Phenylierung entsteht aus (I) das Azepinon (III) und aus (IV) das Dimethylapoerysopin (V).
STATIC AND DYNAMIC SORPTION OF NUCLEIC ACIDS AND PROTEINS ON SURFACE OF SORBENTS MODIFIED WITH NANOLAYERS OF POLYMERS (2017)

Sorption properties of composite silica sorbents modified with nanolayers of fluoropolymers; polyanilines and polyaramides containing aromatic nitrogen; fluorine; as well as donor and acceptor fragments; with respect to nucleic acids (DNA and RNA) and proteins differing in molecular weight and pI are considered. The use of the investigated sorbents in the sample preparation for molecular diagnostics (in particular; in the PCR analysis) not only provides a one-step isolation of nucleic acids; but also allows the isolation and simultaneous purification of protein compounds from the impurities presented in the initial mixture. For the first time; the properties of these materials are compared in the static sorption regime using the compact spin-columns and in the regime of dynamic sorption by the method of spectral-correlation interferometry. The effect of the chemical composition; morphology; and surface charge of these polymer coatings on their sorption properties was studied. Possible mechanisms of sorption of biopolymers on the investigated sorbents are discussed. The use of the developed approaches to the analysis of properties of the sorbents as well as the obtained data open new possibilities for the synthesis of composite sorbents with specific properties. PANI and polyaramides were shown to demonstrate the similar sorption properties when interacting with nucleic acids; but they differ in a various extent in the retention of various proteins. In a neutral aqueous medium (optimal for separation of biopolymers) polyaramides; although did not retain DNA; had a weaker affinity to proteins as compared to PANI. Since the recovery of DNA passed through the PANI-coated silica was the maximal among the particulate adsorbents; the PANI-modified composites were preferred as the carriers for the single-step isolation of nucleic acids from complex biological mixtures. The article cites the results of systematic studies of the authors in the development of sorbents for one-step separation and isolation of biopolymers from complex biological mixtures.Forcitation:Liaw D.-J.; Zybin D.I.; Prostyakova A.I.; Yagudaeva E.Yu.; Vikhrov A.A.; Ishchenko A.A.; Zubov V.P.; Kapustin D.V. Static and dynamic sorption of nucleic acids and proteins on surface of sorbents modified with nanolayers of polymers. Izv. Vyssh. Uchebn. Zaved. Khim. Khim. Tekhnol. 2018. V. 61. N 1. P. 4-22
EMT markers in lung adenocarcinoma pleural effusion spheroid cells (2012)

Epithelial-to-mesenchymal transition (EMT) is a process in which cells undergo a developmental switch from epithelial to mesenchymal phenotype. This process has been related to embryologic morphogenesis but also to cancer progression and metastasis. The aim of the current study was to investigate the expression of EMT-related markers in adherent and spheroid cell cultures derived from malignant pleural effusions (MPEs) of patients affected by lung adenocarcinoma. On the basis of efficient in vitro propagation, six cases of MPEs were selected and analyzed by immunocytochemistry staining for EMT markers and by RT-PCR for transcription factors known to orchestrate EMT. EMT markers immunostaining showed in spheroids a statistically significant correlation between the loss of E-cadherin immunoreactivity and overexpression of N-cadherin (P < 0.001). Likewise loss of EpCAM epithelial marker was coincident with Vimentin overexpression (P < 0.001). RT-PCR analysis of transcription factors Snail, Slug, and Twist showed a highly variable expression, although a general trend to increase was observed. Importantly, in some selected cases it was possible to establish a precise relationship between spheroid formation, EMT switch and increased upregulation of the marker related to cancer stemness such as ALDH positivity. Therefore, MPE-derived cell cultures, while recapitulating the heterogeneity of lung cancer, are a suitable system to study the mechanisms at the basis of EMT and to understand its relationship with the generation of cancer stem cells.
Computation of mean effective gain from 3D measurements (2003)

Performance evaluation of antennas used in the a mobile radio channel is a non-trivial task because of the multipath propagation inherent to this type of channel. A useful measure of the performance of a given antenna is the mean effective gain (MEG) which is the mean received power relative to some reference. In this paper computation of the MEG is investigated based on measurements of the 3D signal distribution in an indoor environment, where the transmitter is placed outside, as in a typical urban micro cell. A main advantage of the method used is that performance testing of different antenna designs in an environment can be carried out with a single propagation measurement and measurements of the antenna radiation patterns. In the paper MEG results are given for different receiver locations in the building for three typical cellular handset antennas and the results are verified with propagation measurements made directly with the antennas.
Heterologous protein secretion in Lactococcus lactis: a novel antigen delivery system (1999)

Lactic acid bacteria (LAB) are Gram-positive bacteria and are generally regarded as safe (GRAS) organisms. Therefore, LAB could be used for heterologous protein secretion and they are good potential candidates as antigen delivery vehicles. To develop such live vaccines, a better control of protein secretion is required. We developed an efficient secretion system in the model LAB, Lactococcus lactis. Staphylococcal nuclease (Nuc) was used as the reporter protein. We first observed that the quantity of secreted Nuc correlated with the copy number of the cloning vector. The nuc gene was cloned on a high-copy number cloning vector and no perturbation of the metabolism of the secreting strain was observed. Replacement of nuc native promoter by a strong lactococcal one led to a significant increase of nuc expression. Secretion efficiency (SE) of Nuc in L. lactis was low, i.e., only 60% of the synthesized Nuc was secreted. Insertion of a synthetic propeptide between the signal peptide and the mature moiety of Nuc increased the SE of Nuc. On the basis of these results, we developed a secretion system and we applied it to the construction of an L. lactis strain which secretes a bovine coronavirus (BCV) epitopeprotein fusion (BCV-Nuc). BCV-Nuc was recognized by both anti-BCV and anti-Nuc antibodies. Secretion of this antigenic fusion is the first step towards the development of a novel antigen delivery system based on LAB-secreting strains.
Neural Neighborhood Encoding for Classification (2020)

Inspired by the fruit-fly olfactory circuit, the Fly Bloom Filter [Dasgupta et al., 2018] is able to efficiently summarize the data with a single pass and has been used for novelty detection. We propose a new classifier (for binary and multi-class classification) that effectively encodes the different local neighborhoods for each class with a per-class Fly Bloom Filter. The inference on test data requires an efficient {\tt FlyHash} [Dasgupta, et al., 2017] operation followed by a high-dimensional, but {\em sparse}, dot product with the per-class Bloom Filters. The learning is trivially parallelizable. On the theoretical side, we establish conditions under which the prediction of our proposed classifier on any test example agrees with the prediction of the nearest neighbor classifier with high probability. We extensively evaluate our proposed scheme with over $50$ data sets of varied data dimensionality to demonstrate that the predictive performance of our proposed neuroscience inspired classifier is competitive the the nearest-neighbor classifiers and other single-pass classifiers.
LOW-COST RAPID-RESPONSE EMBEDDED ANTENNA DESIGN FOR US ARMY 60MM MORTARS (2007)

ITC/USA 2007 Conference Proceedings / The Forty-Third Annual International Telemetering Conference and Technical Exhibition / October 22-25, 2007 / Riviera Hotel & Convention Center, Las Vegas, Nevada
Allele-specific differences in transcriptome, miRNome, and mitochondrial function in two hypertrophic cardiomyopathy mouse models (2018)

Hypertrophic cardiomyopathy (HCM) stems from mutations in sarcomeric proteins that elicit distinct biophysical sequelae, which in turn may yield radically different intracellular signaling and molecular pathologic profiles. These signaling events remain largely unaddressed by clinical trials that have selected patients based on clinical HCM diagnosis, irrespective of genotype. In this study, we determined how two mouse models of HCM differ, with respect to cellular/mitochondrial function and molecular biosignatures, at an early stage of disease. We show that hearts from young R92W-TnT and R403Q-αMyHC mutation-bearing mice differ in their transcriptome, miRNome, intracellular redox environment, mitochondrial antioxidant defense mechanisms, and susceptibility to mitochondrial permeability transition pore opening. Pathway analysis of mRNA-sequencing data and microRNA profiles indicate that R92W-TnT mutants exhibit a biosignature consistent with activation of profibrotic TGF-β signaling. Our results suggest that the oxidative environment and mitochondrial impairment in young R92W-TnT mice promote activation of TGF-β signaling that foreshadows a pernicious phenotype in young individuals. Of the two mutations, R92W-TnT is more likely to benefit from anti-TGF-β signaling effects conferred by angiotensin receptor blockers and may be responsive to mitochondrial antioxidant strategies in the early stage of disease. Molecular and functional profiling may therefore serve as aids to guide precision therapy for HCM.
Assessment of spurious numerical oscillations in high-order spectral difference solvers for supercritical flows (2018)

International audience
Columnar Processing in Primate pFC: Evidence for Executive Control Microcircuits (2012)

A common denominator for many cognitive disorders of human brain is the disruption of neural activity within pFC, whose structural basis is primarily interlaminar (columnar) microcircuits or "minicolumns." The importance of this brain region for executive decision-making has been well documented; however, because of technological constraints, the minicolumnar basis is not well understood. Here, via implementation of a unique conformal multielectrode recording array, the role of interlaminar pFC minicolumns in the executive control of task-related target selection is demonstrated in nonhuman primates performing a visuomotor DMS task. The results reveal target-specific, interlaminar correlated firing during the decision phase of the trial between multielectrode recording array-isolated minicolumnar pairs of neurons located in parallel in layers 2/3 and layer 5 of pFC. The functional significance of individual pFC minicolumns (separated by 40 μm) was shown by reduced correlated firing between cell pairs within single minicolumns on error trials with inappropriate target selection. To further demonstrate dependence on performance, a task-disrupting drug (cocaine) was administered in the middle of the session, which also reduced interlaminar firing in minicolumns that fired appropriately in the early (nondrug) portion of the session. The results provide a direct demonstration of task-specific, real-time columnar processing in pFC indicating the role of this type of microcircuit in executive control of decision-making in primate brain.
Hormonal Therapy for Prostate Cancer: Toward Further Unraveling of Androgen Receptor Function (2009)

Prostate cancer is a major cause of cancer-related death in men. Prostate cancer is an androgen-responsive tumor and the treatment of advanced prostate cancer involves hormonal therapy. First-line treatment for advanced prostate cancer is androgen deprivation therapy (ADT), usually with agents that suppress gonadotropins through a pituitary mechanism. Gonadotropin-releasing hormone agonists and antagonists both suppress gonadal release of testosterone, although their activity profiles vary. ADT down-regulates androgen receptor (AR) transcriptional activity in the tumor but the response in metastatic disease is transient and tumors progress as castration-resistant prostate cancer (CRPC). Although serum testosterone concentrations decline dramatically with ADT, CRPC growth remains largely dependent on AR activity. Secondary hormonal therapies are then often employed to further dampen AR-driven transcription. These secondary hormonal therapies either further deplete adrenal or intratumoral androgen synthesis, or directly and competitively antagonize AR. New hormonal agents with both of these mechanisms are in clinical trials and show promising activity in patients with CRPC. Abiraterone acetate is an inhibitor of CYP17, which is an enzyme required for the synthesis of all androgens and estrogens. MDV3100 is an AR antagonist that has a higher affinity for AR than any other AR antagonist in clinic use. In phase I and phase II clinical trials, both agents have significant activity. These agents and the promise of the development of others provide hope that more effective hormonal therapies may soon be offered to patients, which will improve clinical outcomes.
Effects of Inlet Swirl Angle on Flow and Heat Transfer in Contoured Turbine Nozzle Guide Vanes (2001)

Abstract Computations, based on the ensemble-averaged compressible Navier-Stokes equations closed by the shear-stress transport (SST) model of turbulence, were performed to investigate the effects of inlet swirl angle on the three-dimensional flow and heat transfer in two contoured endwall configurations. Swirl angles investigated include three constant angles (0°, 15°, 30°) and a linearly varying angle from +30° at one endwall to −30° at the other. For all swirl angles, the mass-flow rate through the nozzle was fixed so that the higher the swirl angle, the higher is the velocity magnitude. Of the two endwalls investigated, one has all of the contouring upstream of the airfoil (C1), and another has contouring that starts upstream of the airfoil and continues until the airfoil’s trailing edge (C2). Computed results show that at all swirl angles investigated, the C2 configuration was able to reduce significantly secondary flows on the contoured endwall. Results also show that with reduced secondary flows, the heat-transfer coefficients are also reduced on the suction surface next to the juncture, where the airfoil meets the contoured endwall. On aerodynamics, the C2 configuration was found to produce essentially the same lift as the C1 configuration, but does so with less loss in stagnation pressure. For the C1 configuration, secondary flows are quite pronounced, and they increase slightly in size and in magnitude when swirl angle is increased. However, aerodynamic loss and surface heat transfer were found to decrease with increase in swirl angle. One explanation is that increasing the swirl angle shifted the stagnation zone downstream on the pressure surface to a flatter portion of the airfoil, producing a thicker boundary layer at the stagnation zone, and this changed considerably the evolution of the turbulent boundary layer. When the swirl angle varied linearly from +30° to −30°, increasing the velocity component towards the pressure surface was found to enhance instead of suppress the formation of secondary flows.
Coupled FEM and lumped circuit model of the electromagnetic response of coaxially insulated windings in two slot cores (2007)

Abstract This paper presents a coupled FEM and lumped circuit modelling approach that is primarily intended for high‐frequency and overvoltage simulations of rotating electric machines with coaxially insulated windings, such as Powerformer and Motorformer. The magnetic fields and their interaction with the conductors of the winding are simulated with the aid of a FEM‐program. The displacement current and its losses are modelled with an external lumped circuit. To consider eddy current losses, the stranded conductors and the laminated steel cores are replaced by homogeneous bodies with similar losses over a wide frequency range. The approach is illustrated and experimentally verified for a set‐up with a cable wound around two slot cores. The model agrees well with measurements up to 1 MHz. Copyright © 2007 John Wiley &amp; Sons, Ltd.
A General Theory Of Time-sequential Sampling (2005)

In this paper, we consider the problem of optimum sampling of spatiotemporal signals. Recently, there has been increasing interest in this topic partly due to the advent of next generation television systems, and partly due to the growing need for sophisticated real time vision modules used in a variety of motion estimation and tracking tasks. Time-sequential sampling is a sampling paradigm in which samples are taken from the signal, one at a time, according to a prescribed ordering which is repeated after one complete frame of data is acquired. This paper extends previous work on time-sequential sampling [l] to include sampling on lattices with arbitrary geometries as well as sampling patterns which are replicated with arbitrary periodicities on these lattices. As a result, a unifying theory is developed which includes such classical field-instantaneous patterns as field-quincunx (body-centered orthorhombic lattice) and line-quincunx (hexagonal lattice with four field periodicity), proposed for downsampling of high-definition television signals, as specific examples. In this context, downsampling, e.g. from 2:l line-interlaced to one of the above patterns, can be analyzed in a straightforward manner. Such a treatment of downsampling also provides a systematic way for studying the aliasing effects of the ordering in which a signal is downsampled. The design and analysis of time-sequential sampling patterns is facilitated by introducing a powerful technique from the geometry of numbers which permits these tasks to be carried out in a coordinate system where the time-sequential patterns are rectangularly periodic. The resulting anti-aliasing patterns have a congruential structure. By further extending the theory to include time-sequential sampling on selected cosets of a lattice, we can analyze those sampling strategies for which the spectral replications are not confined to a geometrical lattice. This is the case with the bit-reversed sampling pattern.
Direct determination of Burgers vector sense and magnitude of elementary dislocations by synchrotron white x-ray topography (2008)

The x-ray topography by using highly coherent beam obtained at third-generation synchrotron facilities can provide higher spatial resolution and higher lattice-distortion sensitivity than those by former-generation facilities. Here, we report the direct determination of the Burgers vector senses and magnitudes of elementary dislocations in a high-quality silicon carbide single crystal using white x-ray section topography with a long sample-to-film distance. Our data strongly indicate that there are very weak but extraordinarily long-range elastic interactions between elementary screw dislocations. Those interactions govern dislocation-propagation behavior and the distribution of dislocations. Moreover, we found that white x-ray projection topography with a long sample-to-film distance can also be a powerful tool to effectively examine the detailed structure of elementary dislocations in single crystals.
<title>Robust registration method for interventional MRI-guided thermal ablation of prostate cancer</title> (2001)

We are investigating methods to register live-time interventional magnetic resonance imaging (iMRI) slice images with a previously obtained, high resolution MRI image volume. The immediate application is for iMRI-guided treatments of prostate cancer. We created and evaluated a slice-to-volume mutual information registration algorithm for MR images with special features to improve robustness. Features included a multi-resolution approach and automatic restarting to avoid local minima. We acquired 3D volume images from a 1.5 T MRI system and simulated iMRI images. To assess the quality of registration, we calculated 3D displacement on a voxel-by-voxel basis over a volume of interest between slice-to-volume registration and volume-to- volume registrations that were previously shown to be quite accurate. More than 500 registration experiments were performed on MR images of volunteers. The slice-to-volume registration algorithm was very robust for transverse images covering the prostate. A 100% success rate was achieved with an acceptance criterion of &lt;1.0 mm displacement error over the prostate. Our automatic slice-to-volume mutual information registration algorithm is robust and probably sufficiently accurate to aid in the application of iMRI- guided thermal ablation of prostate cancer.
Further characterization of CSAP, an antigen associated with gastrointestinal and ovarian tumors (1978)

Colon-specific antigen-p, or CSAp, was originally extracted from GW-39 tumors, which are human colonic carcinomas serially transplanted in golden hamsters, and antibodies to CSAp have been produced in the same animal hosts. By means of immunodiffusion and a hemagglutination-inhibition assay, CSAp has been found to be restricted to adult and fetal small intestine, neoplastic gastric and colonic tissues, inflamed colon, and cystic mucinous tumors of the ovary. CSAp was shown to be distinct from blood group antigens, including Lea and Leb blood group substances, liver ferritin, AFP, CEA, CSA, CMA, ZGM, and BOFA, and to have the electrophoretic mobility of an alpha2-globulin. Gel filtration studies indicated that CSAp in GW-39 tumor, primary human colonic carcinoma, and ovarian cancer mucinous cyst fluid had a peak molecular size range of 70,000--110,000. Quantitation of CSAp in 214 tissue specimens by the hemagglutination-inhibition assay revealed a progressive increase in fetal, inflamed, and neoplastic intestine, such that CSAp in colonic tumors was increased over normal colon tissue. Thus, CSAp appears to be an organ-specific antigen showing increased levels in some gastrointestinal and ovarian neoplasms, as well as in specimens with colitis.
Dielectric analysis of intergrated ceramic thin film capacitors (1997)

Abstract The paper presents a survey on the dielectric analysis of integrated ceramic capacitors. The thin film examples are based on high–permittivity paraelectric SrTiO3, solid–solution (Ba,Sr)TiO3, ferroelectric Pb(Zr,Ti)O3, and superparaelectric BaTiO3. The current state of knowledge concerning the temperature dependence, the voltage dependence, and the frequency dependence of the permittivity and the losses is reviewed. The relation of the dielectric properties to the processing and microstructure of the ceramic thin films is outlined. With respect to the understanding of the leakage mechanism, further evidence for a complete depletion of the titanate films is presented and a refined quantitative model of the field dependence is sketched.