gebhart/patrepeval huggingface dataset:
Single Image Depth Estimation using Wavelet Decomposition (2021)

We present a novel method for predicting accurate depths from monocular images with high efficiency. This optimal efficiency is achieved by exploiting wavelet decomposition, which is integrated in a fully differentiable encoder-decoder architecture. We demonstrate that we can reconstruct high-fidelity depth maps by predicting sparse wavelet coefficients. In contrast with previous works, we show that wavelet coefficients can be learned without direct supervision on coefficients. Instead we supervise only the final depth image that is reconstructed through the inverse wavelet transform. We additionally show that wavelet coefficients can be learned in fully self-supervised scenarios, without access to ground-truth depth. Finally, we apply our method to different state-of-the-art monocular depth estimation models, in each case giving similar or better results compared to the original model, while requiring less than half the multiply-adds in the decoder network. Code at this https URL
Micro-Encapsulation (2016)

In the past, aggregation and self-assembly have been associated principally with micellar and colloidal systems of molecules; however, with the advent of supramolecular chemistry, molecular self-assembly has been opened to a much wider understanding that has facilitated access to a variety of different shapes and sizes, along with the construction of new and fascinating molecular topologies. This document aims at defining more than 150 terms related to aggregation and self-assembly in the particular case of macromolecules. The list is restricted to the most commonly encountered terms.
Heightened aberrant deposition of hard-wearing elastin in conduit arteries of prehypertensive SHR is associated with increased stiffness and inward remodeling (2008)

Elastin is a major component of conduit arteries and a key determinant of vascular viscoelastic properties. Aberrant organization of elastic lamellae has been reported in resistance vessels from spontaneously hypertensive rats (SHR) before the development of hypertension. Hence, we have characterized the content and organization of elastic lamellae in conduit vessels of neonatal SHR in detail, comparing the carotid arteries from 1-wk-old SHR with those from Wistar-Kyoto (WKY) and Sprague Dawley (SD) rats. The general structure and mechanics were studied by pressure myography, and the internal elastic lamina organization was determined by confocal microscopy. Cyanide bromide-insoluble elastin scaffolds were also prepared from 1-mo-old SHR and WKY aortas to assess their weight, amino acid composition, three-dimensional lamellar organization, and mechanical characteristics. Carotid arteries from 1-wk-old SHR exhibited narrower lumen and greater intrinsic stiffness than those from their WKY and SD counterparts. These aberrations were associated with heightened elastin content and with a striking reduction in the size of the fenestrae present in the elastic lamellae. The elastin scaffolds isolated from SHR aortas also exhibited increased relative weight and stiffness, as well as the presence of peculiar trabeculae inside the fenestra that reduced their size. We suggest that the excessive and aberrant elastin deposited in SHR vessels during perinatal development alters their mechanical properties. Such abnormalities are likely to compromise vessel expansion during a critical period of growth and, at later stages, they could compromise hemodynamic function and participate in the development of systemic hypertension.
Long wavelength high-speed semiconductor lasers with carrier transport effects (1992)

Carrier transport has a significant effect on the high-speed characteristics of semiconductor lasers. The authors show theoretically and experimentally that the low frequency rolloff and excess increase of damping due to carrier transport significantly limits the high-speed modulation bandwidth of long wavelength InGaAs(P)-InP quantum-well lasers. The inherent small conduction band offset and small hole diffusion constant of this material are responsible for the severe carrier transport effects. The authors also discuss the optimum design for the high speed modulation of the long wavelength lasers and the advantages of the InGaAlAs-InP material system.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Probing neuropeptide volume transmission in vivo by a novel all-optical approach (2021)

Abstract Neuropeptides are essential signaling molecules in the nervous system involved in modulating neural circuits and behavior. Although hypothesized to signal via volume transmission through G-protein coupled receptors (GPCR), remarkably little is known about their extrasynaptic diffusion. Here, we developed an all-optical approach to probe neuropeptide volume transmission in mouse neocortex. To control neuropeptide release, we engineered photosensitive nanovesicles with somatostatin-14 (SST) that is released with near-infrared light stimulation. To detect SST, we created a new cell-based neurotransmitter fluorescent engineered reporter (CNiFER) using the SST2 GPCR. Under two-photon imaging, we determined the time to activate SST2R at defined distances as well as the maximal distance and loss rate for SST volume transmission in neocortex. Importantly, we determined that SST transmission is significantly faster in neocortex with a chemically degraded extracellular matrix, a diseased condition indicated in neuroinflammation and Parkinson’s disease. These new neurotechnologies can reveal important biological signaling processes previously not possible, and provide new opportunities to investigate volume transmission in the brain.
EVIDENCE THAT THERAPEUTIC STRATEGIES TARGETED AT CD4+ CELLS MODULATE ACCELERATED REJECTION OF CARDIAC ALLOGRAFTS IN SENSITIZED RATS BY DIFFERENT MECHANISMS (1992)

(LEW x BN)F1 cardiac allografts are rejected within 36 hr in LEW rats presensitized with BN skin grafts 7 days earlier (acute rejection occurs within 8 days). We have previously described the effects of individual CD4 (BWH-4), CD25 (IL-2R, ART-18) mAbs, and CsA therapeutic regimens upon cardiac allograft survival in sensitized hosts. The present studies were designed to probe an adjunctive use of ART-18 or CsA upon BWH-4-mediated suppression of accelerated graft injury. Sequential therapy with BWH-4 and ART-18 in the sensitization phase (days -7 to -1) and effector phase (from day 0, the day of cardiac transplant), respectively, prolonged graft survival additively to c. 22 days. Treatment with BWH-4 markedly diminished host humoral response against ART-18 preparation. BWH-4 given in concert with subtherapeutic dose of CsA produced graft survival comparable to that induced by mAb alone (c. 13 days) with concomitant decreased host anti-BWH-4 response. None of the combined regimens affected the frequency of circulating CD4+ cells, as compared with that exerted by BWH-4 monotherapy. Thus this study defines principles and some mechanistic aspects of optimal immunosuppressive strategies potentiating the effects of CD4-targeted therapy.
Dactylolide, a New Cytotoxic Macrolide from the Vanuatu SpongeDactylospongia sp. (2001)

Dactylolide (1), a new cytotoxic 20-membered macrolide, was isolated from a marine sponge of the genus Dactylospongia collected off the coast of the Vanuatu islands. It co-occurred with other known bioactive macrolides: latrunculin A (2), laulimalide (3), isolaulimalide (4) and with the anthelminthic mycothiazole (5). The structure of 1, which is a minor metabolite, was elucidated by spectroscopy (mainly by 1D/2D NMR and MS techniques). It showed cytotoxic activity against the L1210 and SK-OV-3 tumor cell lines (63% and 40% inhibition at 3.2 μg/mL).
Lysozyme-catalysed hydrolysis of some β-aryl di-N-acetylchitobiosides (1967)

1. Four beta-aryl di-N-acetylchitobiosides and beta-S-phenyl di-N-acetylthiochitobioside have been prepared and shown to be substrates for hen's-egg-white lysozyme. 2. The lysozyme-catalysed hydrolysis of these substrates obeys Michaelis-Menten kinetics. 3. The Michaelis constants, K(m), for the beta-aryl di-N-acetyl-chitobiosides are almost independent of the aglycone, whereas the catalytic constants, k(cat.), show a marked dependence, giving a Hammett reaction constant, rho, equal to 1.2; this suggests the rate-determining step involves concerted acid-base or acid-nucleophilic catalysis. 4. This conclusion is supported by the Michaelis-Menten constants found for beta-S-phenyl di-N-acetylthiochitobioside. 5. A three-step reaction pathway is proposed, and mechanisms are suggested that would account for the evidence currently available.
SUCCESSFUL REVERSAL OF SPONTANEOUS DIABETES IN DOGS BY INTRAPERITONEAL MICROENCAPSULATED ISLETS (1992)

Long-term euglycemia by intraperitoneal transplantation of microencapsulated islets has not been described in the diabetic large animal model. In this study, we report the successful long-term reversal of diabetes by this method in spontaneous diabetic dogs. We have identified fundamental mechanism(s) associated with alginate-based microcapsule fibrosis, and have devised methods to ameliorate this problem. These include the use of purified alginate of low mannuronic acid content and cytokine suppression. Ten insulin-dependent, spontaneous diabetic dogs (insulin requirement 1-4 units/kg/day; absence of circulating C-peptide and diabetic K-values of 0.6 +/- 0.4) were entered into the study. Islets from mongrel donor pancreata were isolated and transplanted intraperitoneally either as free islet controls (n = 3) or as microencapsulated islet allografts (n = 7). In all seven encapsulated islet recipients, euglycemia was achieved within 24 hr (serum glucose failing from 304 +/- 117 to 116 +/- 72 mg/dl). IVGTT performed 14 days after islet transplant demonstrated normalization of K-values changing from a pretransplant level of 0.6 +/- 0.4 to 2.6 +/- 0.6. All animals receiving encapsulated islets remained euglycemic, free of the need for exogenous insulin, for a period of 63-172 days, with a median insulin-independence for 105 days. In contrast, recipients receiving free islets rejected their graft within seven days of implantation. In conclusion, this is the first report of long-term successful reversal of spontaneous diabetes in the large animal model by an intraperitoneal injection of encapsulated islets. The potential exists for this form of therapy to be explored in the treatment of type I diabetes in man.
The State and Optical Properties of Crystalline BaTiO<sub>3</sub> Nanoparticles Dispersed in Various Suspension Media (2007)

An investigation has been made on the state of barium titanate (BaTiO3; BTO, hereafter) nanoparticles of 10-15 nm in diameter dispersed in various suspension media, such as 2-methoxyethanol (ethylene glycol monomethyl ether: EGMME) with and without acetylacetone (Acac), ethanol, and isopropanol. The state of the nanoparticles dispersed in these suspension media is deduced from the behavior pattern of their optical transmittance (T), in the wavelength (λ) range of 300-900 nm; the concentration (c) of BTO nanoparticles in the suspensions was varied from 0.01 to 0.25 mol/L. T-c plots obtained for EGMME+Acac and EGMME suspensions at various wavelengths indicate that BTO nanoparticles take two and three different states in the suspensions, respectively, from mono-dispersed to agglomerated states with increasing c.
Maximal postextrasystolic potentiation following multiple extrasystoles: A simple means of myocardial assessment (1983)

To obtain consistent, reproducible postextrasystolic potentiation (PESP), a single closely coupled extrasystole (ES) must be introduced using transvenous pacing. We hypothesized that multiple ES (spontaneous or catheter induced) produce maximal PESP at all coupling intervals (CI). Differences in PESP between single and double ES were assessed in dogs at varying CI by two different methods [systolic time intervals--PEP/LVET, and endocardial markers--ejection fraction (EF)]. Single ES produced variable decreases in PEP/LVET (-8.6 +/- 2.7% (SE) to -22.9 +/- 4.0%) depending on the CI duration. Double ES produced maximal decreases (-26.0 +/- 1.2%) at all CI. A similar relationship was noted for EF following single ES (8.6 +/- 2.7% to 43.0 +/- 4.0%) and double ES (42.9 +/- 1.3%). Double ES produced maximal PESP at all CI. This finding may allow simple myocardial assessment during routine left ventricular catheterization without simultaneous right ventricular catheterization.
Path-Normalized Optimization of Recurrent Neural Networks with ReLU Activations (2016)

We investigate the parameter-space geometry of recurrent neural networks (RNNs), and develop an adaptation of path-SGD optimization method, attuned to this geometry, that can learn plain RNNs with ReLU activations. On several datasets that require capturing long-term dependency structure, we show that path-SGD can significantly improve trainability of ReLU RNNs compared to RNNs trained with SGD, even with various recently suggested initialization schemes.
In vitro evaluation of carboxymethylcellulose effectiveness in releasing Candida albicans from skin strips. (2014)

Development of more effective products for cleansing the skin of microorganisms is enhanced by improved understanding of the mechanisms of attachment, as well as potential removal strategies. This paper describes an in vitro method for use of the cationic exchanger carboxymethylcellulose (CMC) to enhance the removal of the yeast Candida albicans as measured in vitro using human skin tape strippings. Several negatively charged and cationic exchanger compounds were evaluated using a visual release method to determine their ability to prompt release of C. albicans from human skin strips. CMC was further tested using a viable count method to assess its ability to effectively release the yeast from skin strips and to evaluate the effects of pH on CMC performance. CMC microparticles were found to release greater than 95% of bound C. albicans from the skin strips over a broad range of pH values. Interaction of CMC with the overall skin charge appears to result in detachment of C. albicans, a response suggesting that anionic particles may facilitate C. albicans removal from skin.
Fast, sensitive dual-comb CARS spectroscopy with a quasi-dual-comb laser (2021)

Dual-comb coherent anti-Stokes Raman scattering (DC-CARS) spectroscopy is an effective tool for high-speed acquisition of vibrational spectra in the fingerprint region. DC-CARS spectroscopy also provides high spectral resolution by virtue of its ability to cover a large time delay between the pump and probe pulses, from two optical frequency combs with slightly different, fixed pulse repetition rates. However, less than 1% of the incident pulse energy is used to acquire the CARS signal because the repetition interval of the laser pulses (&lt;1 ns) is much longer than the coherence lifetime of molecular vibrations (~3 ps). This results in a low spectral acquisition rate and a low signal-to-noise ratio. Here, we introduce a novel method for DC-CARS spectroscopy with a nearly 100% energy efficiency using a “quasi”-dual-comb laser. Specifically, one of the repetition rates of the two lasers is rapidly modulated by controlling the pumping intensity of a Ti:sapphire laser, so that the group delay between two pulses is shorter than the coherence lifetime of molecular vibrations, while the group delay is monitored with two-color interferometry to calibrate the time-domain CARS signal. With this method, we realized a spectral acquisition rate of 100,000 spectra/s, which is 10x higher than conventional DC-CARS spectroscopy. Due to its ~100% energy efficiency, sensitivity at this record high acquisition rate is even higher than conventional DC-CARS spectroscopy operating at a slower acquisition rate of 10,000 spectra/s. Our method holds promise for diverse applications in fields ranging from materials science to life science, such as high-throughput screening, flow cytometry, and live-cell imaging.
Endemic Water and Storm Trash to energy via in-situ processing (2020)

Significant capital is spent removing and disposing of biomass detritus produced by natural disasters and invasive species infestations. This presents an opportunity to turn the cleanup of these endemic wastes into cost-effective, sustainable bioenergy. Using hurricane debris and invasive water hyacinth as case studies, the results of the presented analysis show that carefully designed, relocatable biofuel facilities that produce energy from biowaste can be cost-competitive and carbon-negative compared to status quo baselines. Techno-economic and carbon accounting analyses show that bioenergy can be economical and sustainable over a range of debris scenarios and facility parameters. Transportation modeling shows that by integrating collection, volume reduction, and transportation, delivered feedstock costs can be reduced by 30–87% compared to status quo costs. For the case of hurricane debris, electricity from biomass boilers and pyrolysis generators with 70% capital utilization are competitive with diesel generators at 4 MW and 1.5 MW scales, respectively. For water hyacinth, anaerobic digestion paired with a harvester that gathers, crushes, and bags plants directly on the water could produce useful heat for a net profit of $9/GJ while offsetting 3 tons CO2e per GJ. Ultimately, the present work shows that careful design and evaluation of bioenergy systems could enable an endemic Water and Storm Trash to Energy Via In situ Processing (WASTE VIP) system that reduces cleanup costs, increases energy security, and converts costly biomass waste into cleaner, cheaper energy.
High precision hybrid RF and ultrasonic chirp-based ranging for low-power IoT nodes (2020)

Abstract Hybrid acoustic-RF systems offer excellent ranging accuracy, yet they typically come at a power consumption that is too high to meet the energy constraints of mobile IoT nodes. We combine pulse compression and synchronized wake-ups to achieve a ranging solution that limits the active time of the nodes to 1 ms. Hence, an ultra low-power consumption of 9.015 µW for a single measurement is achieved. The operation time is estimated on 8.5 years on a CR2032 coin cell battery at a 1 Hz update rate, which is over 250 times larger than state-of-the-art RF-based positioning systems. Measurements based on a proof-of-concept hardware platform show median distance error values below 10 cm. Both simulations and measurements demonstrate that the accuracy is reduced at low signal-to-noise ratios and when reflections occur. We introduce three methods that enhance the distance measurements at a low extra processing power cost. Hence, we validate in realistic environments that the centimeter accuracy can be obtained within the energy budget of mobile devices and IoT nodes. The proposed hybrid signal ranging system can be extended to perform accurate, low-power indoor positioning.
Structure of DL-dichloro(trans-1,2-diamino-trans-3,6-cyclohexanediol)platinum(II) monohydrate, [PtCl2(C6H14N2O2)].H2O (1991)

Cristallisation dans P2 1 /c avec a=10,919, b=10,520, c=9,789 A, β=103,26 o , Z=4; affinement jusqu'a R=0,0310. Le compose est d'un interet biologique en tant que agent antitumeur. L'analyse aux rayons X a permis d'etablir la configuration des substituants. Une molecule d'eau est liee par l'hydrogene a l'un des hydroxyls
Serum soluble interleukin-2 receptor levels in rheumatoid arthritis: correlation with clinical and immunological parameters and with the response to auranofin treatment. (1994)

Serum sIL-2R level is not a good index of activity in RA patients and is not a useful marker of response to AU therapy.
The Apoptosome: Heart and Soul of the Cell Death Machine (1999)

Apoptosis is a fundamental biologic process by which metazoan cells orchestrate their own self-demise. Genetic analyses of the nematode C elegans identified three core components of the suicide apparatus which include CED-3, CED-4, and CED-9. An analogous set of core constituents exists in mammalian cells and includes caspase-9, Apaf-1, and bcl-2/xL, respectively. CED-3 and CED-4, along with their mammalian counterparts, function to kill cells, whereas CED-9 and its mammalian equivalents protect cells from death. These central components biochemically intermingle in a ternary complex recently dubbed the "apoptosome." The C elegans protein EGL-1 and its mammalian counterparts, pro-apoptotic members of the bcl-2 family, induce cell death by disrupting apoptosome interactions. Thus, EGL-1 may represent a primordial signal integrator for the apoptosome. Various biochemical processes including oligomerization, adenosine triphosphate ATP/dATP binding, and cytochrome c interaction play a role in regulating the ternary death complex. Recent studies suggest that cell death receptors, such as CD95, may amplify their suicide signal by activating the apoptosome. These mutual associations by core components of the suicide apparatus provide a molecular framework in which diverse death signals likely interface. Understanding the apoptosome and its cellular connections will facilitate the design of novel therapeutic strategies for cancer and other disease states in which apoptosis plays a pivotal role.
Synchronization and Channel Estimation in Wireless CDMA Systems (2006)

Wireless CDMA (code division multiple access) systems need proper synchronization and channel estimation to provide a desirable transmission quality. Here, the authors will discuss techniques which are suitable for the application in the UMTS (Universal Mobile Telecom-munications System) FDD (Frequency Domain Duplex) mode WCDMA (Wideband Code Division Multiple Access). In particular, the manuscript will focus on the implementation of sliding correlation based novel fast iterative tap amplitude and delay estimation for RAKE receivers required for the downlink. This algorithm shall be abbreviated by CITADE. Texas Instruments' TMS320C6416 DSP (Digital Signal Processor), operating at 720 MHz clock rate, will be taken as the target hardware for the implementation of CITADE, exploiting both the hierarchical structure of the primary synchronization channel (PSC) code and the tailored instructions of the TMS32OC6416 DSP. The demand on computational power of the discussed CITADE algorithm is smaller by a factor of approx. 3.6 than the minimum requirements of the algorithm presented in [1], which was implemented on StarCoreTM SC140 DSP. Furthermore, this communication will give a detailed discussion about the authors' view on software defined and cognitive radio applicable to WCDMA. The authors will first consider important aspects of software radio and then present a novel approach on cognitive radio. As proof of concept a demonstrator termed "FALCON" which has been realized by the authors, will be illustrated.