gebhart/patrepeval huggingface dataset:
Higher risk of death among MEN1 patients with mutations in the JunD interacting domain: a Groupe d’étude des Tumeurs Endocrines (GTE) cohort study (2013)

Multiple endocrine neoplasia syndrome type 1 (MEN1), which is secondary to mutation of the MEN1 gene, is a rare autosomal-dominant disease that predisposes mutation carriers to endocrine tumors. Although genotype-phenotype studies have so far failed to identify any statistical correlations, some families harbor recurrent tumor patterns. The function of MENIN is unclear, but has been described through the discovery of its interacting partners. Mutations in the interacting domains of MENIN functional partners have been shown to directly alter its regulation abilities. We report on a cohort of MEN1 patients from the Groupe d'étude des Tumeurs Endocrines. Patients with a molecular diagnosis and a clinical follow-up, totaling 262 families and 806 patients, were included. Associations between mutation type, location or interacting factors of the MENIN protein and death as well as the occurrence of MEN1-related tumors were tested using a frailty Cox model to adjust for potential heterogeneity across families. Accounting for the heterogeneity across families, the overall risk of death was significantly higher when mutations affected the JunD interacting domain (adjusted HR = 1.88: 95%-CI = 1.15-3.07). Patients had a higher risk of death from cancers of the MEN1 spectrum (HR = 2.34; 95%-CI = 1.23-4.43). This genotype-phenotype correlation study confirmed the lack of direct genotype-phenotype correlations. However, patients with mutations affecting the JunD interacting domain had a higher risk of death secondary to a MEN1 tumor and should thus be considered for surgical indications, genetic counseling and follow-up.
Traumatic brain injury in Africa in 2050: a modeling study (2015)

Projected estimates of TBI in Africa are high, with a burden of anywhere between approximately 6 and 14 million new cases in 2050. This emphasizes the importance of developing accurate surveillance systems of TBI at a population level and public health measures to mitigate the risk and burden of TBI.
Demonstration of two-dimensional photonic crystals based on silicon carbide (2011)

We demonstrate two-dimensional photonic crystals of silicon carbide (SiC)-a wide bandgap semiconductor and one of the hardest materials-at near-infrared wavelengths. Although the refractive index of SiC is lower than that of a conventional semiconductor such as GaAs or Si, we show theoretically that a wide photonic bandgap, a broadband waveguide, and a high-quality nanocavity comparable to those of previous photonic crystals can be obtained in SiC photonic crystals. We also develop a process for fabricating SiC-based photonic crystals that experimentally show a photonic bandgap of 200 nm, a waveguide with a 40-nm bandwidth, and a nanocavity with a high quality factor of 4,500. This demonstration should stimulate further development of resilient and stable photonics at high power and high temperature analogous to SiC power electronics.
Evaluation of Cyantraniliprole and Other Commercial Fly Baits under Laboratory and Field Conditions (2015)

Laboratory and field trials were performed to evaluate the attractiveness and efficacy of commercial baits (cyantraniliprole; methomyl + (Z)-9-tricosene; dinotefuran + (Z)-9-tricosene; imidacloprid granular + (Z)-9-tricosene; and imidacloprid liquid + (Z)-9-tricosene). In choice tests; flies were most attracted to cyantraniliprole bait > dinotefuran + (Z)-9 > methomyl + (Z)-9 bait > imidacloprid granular + (Z)-9 bait > imidacloprid liquid + (Z)-9 bait. Significant degradation in bait efficacy was observed after two weeks of aging excluding imidacloprid granular; which began to degrade in field conditions after one week. Cyantraniliprole; the new fly bait active ingredient in Zyrox(®); had the longest time to knockdown in the laboratory tests; but on susceptible flies; achieved 95%-100% knockdown within an hour of exposure. Zyrox(®) was resistant to weathering for a week; and was more attractive to flies in the field when compared to methomyl + (Z)-9 bait.
Quantification of the α2–6 Sialic Acid Linkage in Branched N-Glycan Structures with Capillary Nanogel Electrophoresis (2019)

Sialylation and sialic acid linkage in N-glycans are markers of disease but are analytically challenging to quantify. A capillary electrophoresis method is reported that integrates a unique combination of enzymes and lectins to modify sialylated N-glycans in real time in the capillary so that N-glycan structures containing α2-6-linked sialic acid are easily separated, detected, and quantified. In this study, N-glycans were sequentially cleaved by enzymes at the head of the separation capillary so that the presence of α2-6-linked sialic acids corresponded to a shift in the analyte migration time in a manner that enabled interpretation of the N-glycan structure. Following injection, only afucosylated N-glycan structures were passed through enzyme zones that contained α2-3 sialidase, followed by β1-3,4 galactosidase, which cleaved any terminal α2-3-linked sialic acid and underlying galactose yielding a terminal N-acetyl glucosamine. With this treatment complete, a third zone of α2-3,6,8 sialidase converted the remaining α2-6-linked sialic acid to terminal galactose. With these enzyme processing steps the α2-6-linked sialic acid residues on an N-glycan correlated directly to the number of terminal galactose residues that remained. The number of terminal galactose residues could be interpreted as a stepwise decrease in the migration time. Complex N-glycans from α-1-acid glycoprotein were analyzed using this approach, revealing that a limited number of α2-6-linked sialic acids were present with biantennary, triantennary, and tetraantennary N-glycans of α-1-acid glycoprotein generally containing 0 or 1 α2-6-linked sialic acid.
Diversity-Oriented Synthesis Catalyzed by DAST – Preparation of New Antitumor Ecdysteroid Derivatives (2022)

Fluorine represents a privileged building block in pharmaceutical chemistry. Diethylaminosulfur-trifluoride (DAST) is a reagent commonly used for replacement of alcoholic hydroxyl groups with fluorine and is also known to catalyze water elimination and cyclic Beckmann-rearrangement type reactions. In this work we aimed to use DAST for diversity-oriented semisynthetic transformation of natural products bearing multiple hydroxyl groups to prepare new bioactive compounds. Four ecdysteroids, including a new constituent of Cyanotis arachnoidea, were selected as starting materials for DAST-catalyzed transformations. The newly prepared compounds represented combinations of various structural changes DAST was known to catalyze, and a unique cyclopropane ring closure that was found for the first time. Several compounds demonstrated in vitro antitumor properties. A new 17-N-acetylecdysteroid (13) exerted potent antiproliferative activity and no cytotoxicity on drug susceptible and multi-drug resistant mouse T-cell lymphoma cells. Further, compound 13 acted in significant synergism with doxorubicin without detectable direct ABCB1 inhibition. Our results demonstrate that DAST is a versatile tool for diversity-oriented synthesis to expand chemical space towards new bioactive compounds.
pNLP-Mixer: an Efficient all-MLP Architecture for Language (2023)

Large pre-trained language models based on transformer architectureƒhave drastically changed the natural language processing (NLP) landscape. However, deploying those models for on-device applications in constrained devices such as smart watches is completely impractical due to their size and inference cost. As an alternative to transformer-based architectures, recent work on efficient NLP has shown that weight-efficient models can attain competitive performance for simple tasks, such as slot filling and intent classification, with model sizes in the order of the megabyte. This work introduces the pNLP-Mixer architecture, an embedding-free MLP-Mixer model for on-device NLP that achieves high weight-efficiency thanks to a novel projection layer. We evaluate a pNLP-Mixer model of only one megabyte in size on two multi-lingual semantic parsing datasets, MTOP and multiATIS. Our quantized model achieves 99.4% and 97.8% the performance of mBERT on MTOP and multiATIS, while using 170x less parameters. Our model consistently beats the state-of-the-art of tiny models (pQRNN), which is twice as large, by a margin up to 7.8% on MTOP.
Cross-Sectional Assessment of SARS-CoV-2 Viral Load by Symptom Status in Massachusetts Congregate Living Facilities (2021)

Transmission of coronavirus disease 2019 (COVID-19) from people without symptoms confounds societal mitigation strategies. From April to June 2020, we tested nasopharyngeal swabs by reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) from 15 514 staff and 16 966 residents of nursing homes and assisted living facilities in Massachusetts. Cycle threshold (Ct) distributions were very similar between populations with (n = 739) and without (n = 2179) symptoms at the time of sampling (mean Ct, 25.7 vs 26.4; ranges 12-38). However, as local cases waned, those without symptoms shifted towards higher Ct. With such similar viral load distributions, existing testing modalities should perform comparably regardless of symptoms, contingent upon time since infection.
Magnetic agglomeration method for size control in the synthesis of magnetic nanoparticles (2023)

A method for controlling the size of chemically synthesized magnetic nanoparticles that employs magnetic interaction between particles to control particle size and does not rely on conventional kinetic control of the reaction to control particle size. The particles are caused to reversibly agglomerate and precipitate from solution; the size at which this occurs can be well controlled to provide a very narrow particle size distribution. The size of particles is controllable by the size of the surfactant employed in the process; controlling the size of the surfactant allows magnetic control of the agglomeration and precipitation processes. Agglomeration is used to effectively stop particle growth to provide a very narrow range of particle sizes.
Search for the doubly charmed baryon $$ {\varXi}_{cc}^{+} $$ in the $$ {\varXi}_c^{+}{\pi}^{-}{\pi}^{+} $$ final state (2021)

A bstract A search for the doubly charmed baryon $$ {\varXi}_{cc}^{+} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msubsup><mml:mi>Ξ</mml:mi><mml:mi>cc</mml:mi><mml:mo>+</mml:mo></mml:msubsup></mml:math> is performed in the $$ {\varXi}_c^{+}{\pi}^{-}{\pi}^{+} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msubsup><mml:mi>Ξ</mml:mi><mml:mi>c</mml:mi><mml:mo>+</mml:mo></mml:msubsup><mml:msup><mml:mi>π</mml:mi><mml:mo>−</mml:mo></mml:msup><mml:msup><mml:mi>π</mml:mi><mml:mo>+</mml:mo></mml:msup></mml:math> invariant-mass spectrum, where the $$ {\varXi}_c^{+} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msubsup><mml:mi>Ξ</mml:mi><mml:mi>c</mml:mi><mml:mo>+</mml:mo></mml:msubsup></mml:math> baryon is reconstructed in the pK − π + final state. The study uses proton-proton collision data collected with the LHCb detector at a centre- of-mass energy of 13 TeV, corresponding to a total integrated luminosity of 5.4 fb − 1 . No significant signal is observed in the invariant-mass range of 3.4–3.8 GeV/ c 2 . Upper limits are set on the ratio of branching fractions multiplied by the production cross-section with respect to the $$ {\varXi}_{cc}^{++} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msubsup><mml:mi>Ξ</mml:mi><mml:mi>cc</mml:mi><mml:mrow><mml:mo>+</mml:mo><mml:mo>+</mml:mo></mml:mrow></mml:msubsup></mml:math> → ( $$ {\varXi}_c^{+} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msubsup><mml:mi>Ξ</mml:mi><mml:mi>c</mml:mi><mml:mo>+</mml:mo></mml:msubsup></mml:math> → pK − π + ) π + decay for different $$ {\varXi}_{cc}^{+} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msubsup><mml:mi>Ξ</mml:mi><mml:mi>cc</mml:mi><mml:mo>+</mml:mo></mml:msubsup></mml:math> mass and lifetime hypotheses in the rapidity range from 2.0 to 4.5 and the transverse momentum range from 2.5 to 25 GeV/ c . The results from this search are combined with a previously published search for the $$ {\varXi}_{cc}^{+} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msubsup><mml:mi>Ξ</mml:mi><mml:mi>cc</mml:mi><mml:mo>+</mml:mo></mml:msubsup></mml:math> → $$ {\varLambda}_c^{+} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msubsup><mml:mi>Λ</mml:mi><mml:mi>c</mml:mi><mml:mo>+</mml:mo></mml:msubsup></mml:math> K − π + decay mode, yielding a maximum local significance of 4.0 standard deviations around the mass of 3620 MeV/ c 2 , including systematic uncertainties. Taking into account the look-elsewhere effect in the 3.5–3.7 GeV/ c 2 mass window, the combined global significance is 2.9 standard deviations including systematic uncertainties.
Outcome and Complications of Long Fusions to the Sacrum in Adult Spine Deformity (2002)

Attention to sagittal balance is critical in these patients. Revision surgery is as safe and effective as primary surgery. According to the current findings, the Luque-Galveston fixation technique has an unacceptably high rate of pseudarthrosis, and this method is not recommended for adult deformities. Currently, the authors are using bicortical and triangulated sacral screws with an anterior interbody support in patients with good bone stock, but only when the spine balance is restored. Otherwise, they recommend using iliac fixation, although there is a higher rate of painful hardware, requiring removal.
OUES from submaximal cardiopulmonary exercise (2022)

Abstract Introduction Cardiopulmonary exercise testing (CPEX) provides valuable diagnostic and prognostic cardiopulmonary function data. However, in clinical setting a maximal test is not always achievable. The Oxygen Efficiency Uptake Slope (OUES) has been proposed as a possible submaximal measure of cardiopulmonary function as it remains relatively stable during the final quartile of the exercise test. This study explored the validity of OUES as a surrogate marker for cardiopulmonary function in the event of a submaximal test. Methods Four groups of subjects [128 healthy controls (73 M), 44 asymptomatic hypertensive (HT) patients (26 M), 67 adult cardiac congenital heart disease (ACHD) patients (44 M) and 35 Heart Failure with preserved Ejection Fraction (HFpEF) (10M) patients] were recruited after informed consent. All subjects underwent clinical assessment, resting ECG, blood pressure and spirometry prior to a treadmill CPEX to volitional exhaustion and a respiratory exchange ratio (RER) of at least 1.1 using the same testing protocol. Peak VO2 (ml/min) was recorded from the last 5s of the maximal test (RER=1.1) and OUES was calculated from complete (RER=1.1) and truncated (RER=0.9) gas exchange data. The linear relationships between absolute peak VO2 and OUES from complete and truncated gas exchange data were assessed using Pearson's correlation coefficient. Subsequently, the two correlations obtained in each patient group were compared. Statistical significance was set at p&amp;lt;0.01. Results Mean and 95% confidence intervals of the peak VO2 for males and females in each decile of life examined in the 4 subject groups are shown in the Figure. Peak VO2 values achieved in each of the patient groups were significantly lower when matched for age and sex compared to healthy participants (HT p=0.006, ACHD patients p&amp;lt;0.001 and HFpEF patients p&amp;lt;0.001). In all 4 groups there was a good correlation between absolute peak VO2 and the OUES at RER 1.1 (healthy volunteers r=0.910, p&amp;lt;0.001, HT r=0.899, p&amp;lt;0.001, ACHD r=0.816, p&amp;lt;0.001 and HFpEF r=0.846, p&amp;lt;0.001). Correlations were inferior for absolute peak VO2 and OUES at RER 0.9 (healthy volunteers r=0.74, p&amp;lt;0.001, HT r=0.780, p&amp;lt;0.001, ACHD r=0.651, p&amp;lt;0.001 and HFpEF r=0.817, p&amp;lt;0.001). Correlations between absolute peak VO2 vs OUES at RER of 1.1 and 0.9 were significantly different only for healthy controls (p=0.001, Z-score = −4.649), but not for HT (p=0.05, Z-score = −1.909), ACHD (p=0.04, Z-score = −2.080) or HFpEF (p=0.7, Z-score = −0.377) patients. Conclusion Our data support the use of submaximal OUES at an RER of 0.9 as a surrogate marker for absolute peak VO2 obtained at an RER of 1.1, especially in patients, in whom it can often be difficult to achieve maximal exercise. Funding Acknowledgement Type of funding sources: None.
Pharmacokinetics of Eplerenone After Single and Multiple Dosing in Subjects With and Without Renal Impairment (2005)

The influence of renal impairment on the pharmacokinetics of eplerenone following single and multiple dosing was evaluated. Subjects (n = 64) were stratified based on creatinine clearance values as follows: renal impairment (mild, moderate, severe), hemodialysis, and normal matches. Subjects received a single dose of eplerenone 100 mg on day 1 and then received 100 mg once daily on days 3 to 8. There were no statistically significant differences between any of the renal impairment groups and their matched-normal groups for area under the curve (AUC), C(max), or CL/F or CL/F/WT following either single or multiple dosing (P > or = .093). The inactive metabolite and inactive ring-opened form displayed greater AUCs in renal impairment. Hemodialysis removed approximately 10% of the eplerenone dose. Eplerenone 100 mg once daily was well tolerated in all groups. Considering that renal function had no significant effects on eplerenone CL/F and that eplerenone metabolites are inactive, no dose adjustment appears necessary in patients with renal dysfunction.
On the Minimax Capacity Loss Under Sub-Nyquist Universal Sampling (2017)

This paper investigates the information rate loss in analog channels, when the sampler is designed to operate independent of the instantaneous channel occupancy. Specifically, a multiband linear time-invariant Gaussian channel under universal sub-Nyquist sampling is considered. The entire channel bandwidth is divided into n subbands of equal bandwidth. At each time, only k constant-gain subbands are active, where the instantaneous subband occupancy is not known at the receiver and the sampler. We study the information loss through an information , that is, the gap of achievable rates caused by the lack of instantaneous subband occupancy information. We characterize the minimax information rate loss for the sub-Nyquist regime, provided that the number n of subbands and the SNR are both large. The minimax limits depend almost solely on the band sparsity factor and the undersampling factor, modulo some residual terms that vanish as n and SNR grow. Our results highlight the power of randomized sampling methods (i.e., the samplers that consist of random periodic modulation and low-pass filters), which are able to approach the minimax information rate loss with exponentially high probability.
Cofacial assembly of partially oxidized metallamacrocycles as an approach to controlling lattice architecture in low-dimensional molecular solids. Chemical and architectural properties of the "face-to-face" polymers [M(phthalocyaninato)O]n, where M = Si, Ge, and Sn (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCofacial assembly of partially oxidized metallamacrocycles as an approach to controlling lattice architecture in low-dimensional molecular solids. Chemical and architectural properties of the "face-to-face" polymers [M(phthalocyaninato)O]n, where M = Si, Ge, and SnCarl W. Dirk, Tamotsu Inabe, Karl F. Schoch Jr., and Tobin J. MarksCite this: J. Am. Chem. Soc. 1983, 105, 6, 1539–1550Publication Date (Print):March 1, 1983Publication History Published online1 May 2002Published inissue 1 March 1983https://pubs.acs.org/doi/10.1021/ja00344a022https://doi.org/10.1021/ja00344a022research-articleACS PublicationsRequest reuse permissionsArticle Views997Altmetric-Citations227LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Dysregulation of reg gene expression occurs early in gastrointestinal tumorigenesis and regulates anti-apoptotic genes (2006)

Expression of anti-apoptotic genes is frequently elevated in tumors, where they increase resistance to chemotherapeutic agents and predict poor patient outcomes. However, key cellular factors regulating anti-apoptotic genes in tumors remain unknown. Increased expression of the regenerating (Reg) genes is commonly observed in gastrointestinal (GI) malignancies including colorectal cancer (CRC). We therefore examined Reg gene expression and associated changes in anti-apoptotic genes in an animal model of GI tumorigenesis. Using real time RT-PCR, we measured expression of Reg genes in human colorectal adenocarcinoma specimens, colon adenocarcinoma cell lines and adenomas from multiple intestinal neoplasia (min) mice heterozygous for a germ-line mutation of the adenomatous polyposis coli (APC) gene. Expression of Reg genes is increased in human colorectal adenocarcinomas and in the intestine of APCmin/+ mice at four weeks of age, a time preceding the spontaneous second mutation in the APC gene. Individual Reg genes exhibited regional expression profiles across the GI tract in mice. Adenomas from 14-week old mice had significant increases in at least one member of the Reg gene family, most commonly Reg IV and an associated increase in expression of the anti-apoptotic gene, Bcl-2. Addition of exogenous recombinant human Reg IV to human colon adenocarcinoma cells significantly increased Bcl-2 and Bcl-xL expression and induced resistance to ionizing radiation. These results show that dysregulation of Reg genes occur early in tumorigenesis. Furthermore, increased expression of Reg genes, specifically Reg IV contribute to adenoma formation and lead to increased resistance to apoptotic cell death in CRC.
EFFECTS OF ELCATONIN ON PLASMA AND URINE ELECTROLYTES IN INFANT BEAGLES (1982)

The effects of elcatonin (ECT) on the renal hemodynamics and electrolyte levels in plasma and urine were investigated in anesthetized infant beagles (3 months old) and adult beagles (9-10 months old). Intravenous injections of 50 MRC U/kg ECT did not alter the systemic blood pressure, renal blood flow, glomerular filtration rate, and urine flow in intact puppies as well as in puppies and adult dogs subjected to extirpation of the thyroid and parathyroid glands (TPTX). One hundred and twenty min after ECT injection, the plasma calcium concentration decreased by 1.06±0.15 mEq/l in intact puppies and 0.94±0.10 mEq/l in TPTX puppies, but decreased only by 0.38±0.22 mEq/l in adult TPTX dogs. The urinary calcium excretion decreased in all the puppies. The plasma phosphorus concentration decreased by 1.02±0:10 mg/dl, and the phosphorus excretion rate increased 63.6±26.4% in intact puppies; whereas the plasma phosphorus and phosphorus excretion were not altered in TPTX puppies. Diuresis and natriuresis were not obtained. These data suggest that the acute hypocalcemie effect of ECT is dependent on age and is not associated with its action on kidneys.