gebhart/patrepeval huggingface dataset:
The Design of Reagents for Photochemical and Thermal Multiple Electron Transfer Reactions (1992)

Abstract Most, if not all, electron transfer reactions involving more than one electron can be considered as a series of sequential one electron transfer steps when evaluated on an appropriate timescale. Once the critical activation barrier for the first electron transfer to occur has been surmounted, the ensuing electrons are generally transferred in rapid succession. A number of multiple electron, inorganic systems, particularly those containing platinum, are evaluated; and the underlying principles for the design of these systems are discussed. Both thermally and photochemically activated systems are considered. Additionally, new thermodynamic criteria are proposed for certain inner sphere electron transfer reactions.
ChemInform Abstract: Synthesis of Dipeptides Containing α‐Substituted Amino Acids; Their Use as Chiral Ligands in Lewis Acid Catalyzed Reactions. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Development of a method to analyze the impact of manufacturing systems engineering on product quality (2011)

Product quality is one key performance indicator for manufacturing systems with growing importance. Among others it depends strongly on manufacturing properties and parameters defined within the engineering process of the manufacturing system creating these products. Thus, manufacturing systems engineering quality directly influences product quality. To control the reachable product quality within the engineering process, the dependencies between engineering process, manufacturing system, and product have to be known and used within the engineering process as guidance. Within this paper a method is described which can be used to analyze the dependency of product properties and, thereby, product quality from engineering activities.
POD GENERATOR—A QUANTITATIVE ASSESSMENT OF THE PERFORMANCE OF INSPECTION SYSTEMS (2008)

Process installations and pipelines suffer from degradation like corrosion and cracking. The condition is often determined by off‐line inspections, employing non‐destructive testing techniques. These inspection techniques have their limitations in terms of reliability and effectiveness. In the POD generator project, numerical models are being developed and validated, simulating the physics of the degradation mechanisms and the inspections techniques. Also the human factor is taken into account. These validated numerical models can be used to generate so‐called Probability Of Detection (POD) curves.
A direct role of transcription factor E2F in c-myc gene expression during granulocytic and macrophage-like differentiation of HL60 cells. (1995)

The transcription factor E2F is known to play an important role in cell cycle progression through interaction with retinoblastoma protein. HL60 cells are able to differentiate into a granulocytic lineage by prolonged exposure to retinoids and into a macrophage-like lineage by exposure to tumor promoter 12-O-tetradecanoylphorbol 13-acetate, with a rapid decrease of c-myc gene expression. In this study, we assessed the changes of the E2F-binding pattern to the P2 promoter region of the c-myc gene during differentiation into both lineages. The observed changes of the E2F-binding pattern were a decrease of free E2F and an appearance of retinoblastoma protein-containing E2F complexes in both lineages. The effects of the anti-c-myc antibody and the recombinant c-Myc protein on the E2F-binding patterns suggest that the c-Myc protein is not involved directly in these changes. These changes also led the suppression of transcriptional initiation from the P2 promoter. The results indicate that, in the course of HL60 cell differentiation, E2F plays a direct role in the transcriptional control of the c-myc gene through interaction with the retinoblastoma protein. A potential role for the c-Myc protein is discussed in relation to an existing state of E2F and E2F-RB complexes in the HL60 cells.
In Vitro and In Vivo Proteomic Comparison of Human Neural Progenitor Cell‐Induced Photoreceptor Survival (2018)

Retinal degenerative diseases lead to blindness with few treatments. Various cell-based therapies are aimed to slow the progression of vision loss by preserving light-sensing photoreceptor cells. A subretinal injection of human neural progenitor cells (hNPCs) into the Royal College of Surgeons (RCS) rat model of retinal degeneration has aided in photoreceptor survival, though the mechanisms are mainly unknown. Identifying the retinal proteomic changes that occur following hNPC treatment leads to better understanding of neuroprotection. To mimic the retinal environment following hNPC injection, a co-culture system of retinas and hNPCs is developed. Less cell death occurs in RCS retinal tissue co-cultured with hNPCs than in retinas cultured alone, suggesting that hNPCs provide retinal protection in vitro. Comparison of ex vivo and in vivo retinas identifies nuclear factor (erythroid-derived 2)-like 2 (NRF2) mediated oxidative response signaling as an hNPC-induced pathway. This is the first study to compare proteomic changes following treatment with hNPCs in both an ex vivo and in vivo environment, further allowing the use of ex vivo modeling for mechanisms of retinal preservation. Elucidation of the protein changes in the retina following hNPC treatment may lead to the discovery of mechanisms of photoreceptor survival and its therapeutic for clinical applications.
Hemoglobin polymorphism in adult cutthroat trout, Salmo clarkii (1980)

Abstract Hemoglobin polymorphism was detected in a population of adult cutthroat trout by employing starch gel electrophoresis. Variation occurred only in the cathodally migrating hemoglobins. Six electrophoretic patterns were assumed to be present; however, the existence of a greater degree of complexity has not been ruled out. Eight of the 93 adult cutthroat trout sampled displayed a hemoglobin electrophoretic pattern identical to that obtained from adult rainbow trout.
Scalar control: an alternative AC drive philosophy (1988)

A new control philosophy for inverter driven induction motors causes the airgap flux to vary over a wide range in proportion to load-induced changes in the scalar magnitude of the machine current. A controller based on this principle outputs a constant slip frequency at high efficiency under all useful operating conditions. It is stable with good damping factors and good response times, yet it requires no external transducers. It allows for accurate torque estimates, but it can be implemented with low cost microprocessors that can be interfaced to computers for interactive plant control and data analysis. Measured results from a practical inverter are shown to be in close agreement with both the theoretical analysis presented and with computer simulations.
Surface Micromachined Z-Axis Vibratory Rate Gyroscope (1996)

We have designed and tested the first polysilicon surface micromachined vibratory rate gyroscope that is sensitive to angular rotation about an axis normal to the plane of the silicon chip, the Z-axis. The Analog Devices, Inc. BiMEMS technology was used to fabricate the gyroscope, which has as a demonstrated minimum detectable signal of 1 deg/sec/Hz 112 with performance projected to improve to 0.1 deg/sec/Hz 112 in a second-generation BiMEMS design.
Modèles probabilistes pour la recherche d'information (2011)

Chapitre 1
Secondary Ion Mass Spectrometry: A Multidimensional Technique (1985)

This paper discusses SIMS as a multi-dimensional technique for the analysis of inorganic and organic materials. The paper is divided into two parts: inorganic SIMS and organic (molecular) SIMS. The inorganic SIMS part focuses on methods of quantitative analysis and depth profiling applications. In particular, the parameters that makes SIMS difficult to quantify -secondary ion yield, matrix effects, and instrumental effects - are reviewed as well as the various physical models and empirical methods used to quantify SIMS data. The instrumental and experimental parameters that affect SIMS depth profiling are also reviewed. The organic SIMS part discusses the method of ionization and the various sample preparation and matrix-assisted procedures used for analysis. The matrices include various solid-state and liquid matrices such as ammonium chloride, charcoal, glycerol, and gallium. A neutral beam source was developed to analyze thick, insulating films. Various chemical derivatization procedures have been developed to enhance the sensitivity of molecular SIMS and to selectively detect components in mixtures.
Gonadotrophin-induced paracrine regulation of human oocyte maturation by BDNF and GDNF secreted by granulosa cells (2011)

These findings demonstrate that FSH and hCG treatments augment the expression of BDNF and GDNF by granulosa cells and that these granulosa-cell-derived factors are candidate paracrine factors capable of promoting oocyte maturation.
Small-Scale, Local Area, and Transitional Millimeter Wave Propagation for 5G Communications (2017)

This paper studies radio propagation mechanisms that impact handoffs, air interface design, beam steering, and multiple-input multiple-output for 5G mobile communication systems. Knife-edge diffraction (KED) and a creeping wave linear model are shown to predict diffraction loss around typical building objects from 10 to 26 GHz, and human blockage measurements at 73 GHz are shown to fit a double KED model, which incorporates antenna gains. Small-scale spatial fading of millimeter wave (mmWave)-received signal voltage amplitude is generally Ricean-distributed for both omnidirectional and directional receive antenna patterns under both line-of-sight (LOS) and non-line-of-sight (NLOS) conditions in most cases, although the log-normal distribution fits measured data better for the omnidirectional receive antenna pattern in the NLOS environment. Small-scale spatial autocorrelations of received voltage amplitudes are shown to fit sinusoidal exponential and exponential functions for LOS and NLOS environments, respectively, with small decorrelation distances of 0.27-13.6 cm (smaller than the size of a handset) that are favorable for spatial multiplexing. Local area measurements using cluster and route scenarios show how the received signal changes as the mobile moves and transitions from LOS to NLOS locations, with reasonably stationary signal levels within clusters. Wideband mmWave power levels are shown to fade from 0.4 dB/ms to 40 dB/s, depending on travel speed and surroundings.
Concerted Migration Mechanism in the Li Ion Dynamics of Garnet-Type Li7La3Zr2O12 (2013)

The garnet-type Li7La3Zr2O12 (LLZO) belonging to cubic symmetry (space group Ia3̅d) is considered as one of the most promising solid electrolyte materials for all-solid state lithium ion batteries. In this study, the diffusion coefficient and site occupancy of Li ions within the 3D network structure of the cubic LLZO framework have been investigated using ab initio molecular dynamics calculations. The bulk conductivity at 300 K is estimated to be about 1.06 × 10–4 S cm–1 with an energy barrier of 0.331 eV, in reasonable agreement with experimental results. The complex mechanism for self-diffusion of Li ions can be viewed as a concerted migration governed by two crucial features: (i) the restriction imposed for occupied site-to-site interatomic separation, and (ii) the unstable residence of Li ion at the 24d site, which can serve as the trigger for ion mobility and reconfiguration of surrounding Li neighbors to accommodate the initiated movement. Evidence for Li ordering is also found at low temperature for the LLZO system.
Actively controlled super-resolution using graphene-based structure (2014)

A super-resolution (with λ/50 resolution ability at mid-infrared region) device that consists of a monolayer graphene sandwiched between two dielectric materials with two alternate chemical potentials in graphene (which can be obtained by alternately applying two biased voltages to graphene) is proposed and analyzed. When the subwavelength resolution is achieved, the graphene-based device can be viewed as an effective optical medium with alternate arrangement of positive and negative refractive indices. And the isofrequency dispersion curves of the effective optical medium have the hyperbolic form. Furthermore, the super-resolution at different desired frequencies can be reached by merely changing the chemical potentials of graphene. The proposed devices have potential applications in multi-functional material, real-time subwavelength imaging, and high-density optoelectronic components for using the abnormal diffraction feature.
MSW Decontamination: Methods to Improve Biofuel Yields (2022)

MSW is usually contaminated with a variety of undesirable materials (food, chemicals, glass, metal) that can impact downstream applications such as conversion to biofuels. This presentation will showcase two decontamination methods using either a detergent wash or an organic solvent extraction to demonstrate up to 30% increase in biofuel precursor yields for plastic and paper MSW. The economics of the two decontamination methods will also be presented.
Reconciling the Tension Between Hardware Isolation and Data Sharing in Mixed-Criticality, Multicore Systems (2016)

Recent work involving a mixed-criticality framework called MC2 has shown that, by combining hardware-management techniques and criticality-aware task provisioning, capacity loss can be significantly reduced when supporting real-time workloads on multicore platforms. However, as in most other prior research on multicore hardware management, tasks were assumed in that work to not share data. Data sharing is problematic in the context of hardware management because it can violate the isolation properties hardware-management techniques seek to ensure. Clearly, for research on such techniques to have any practical impact, data sharing must be permitted. Towards this goal, this paper presents a new version of MC2 that permits tasks to share data within and across criticality levels through shared memory. Several techniques are presented for mitigating capacity loss due to data sharing. The effectiveness of these techniques is demonstrated by means of a large-scale, overhead-aware schedulability study driven by micro-benchmark data.
BraCoil – preliminary performance evaluation of a wearable breast coil array for 3 T MR mammography (2023)

A dedicated radio frequency coil design for MR mammography needs to optimize sensitivity, reduce scan time, and improve patient comfort to ultimately facilitate diagnosis. We investigate signal-to-noise ratio and parallel imaging performance differences between widely used commercial 16-/18-channel receive coils for breast MRI at 3 T in prone and supine position and an in-house developed 28-channel wearable coil array (&amp;ldquo;BraCoil&amp;rdquo;). An SNR gain of up to a factor of 6 with BraCoil was found in this phantom study.
A Low Power Frequency Synthesizer for 60-GHz Wireless Personal Area Networks (2011)

In this brief, a 60-GHz frequency synthesizer for wireless personal area networks is designed using 0.13- μm CMOS technology. The synthesizer operates at 60 GHz with phase noises of -98, -117, and -128 dBc/Hz at 1-, 10-, and 40-MHz frequency offsets, respectively. The 60-GHz clock is generated by combining a phase-locked loop (PLL) and an injection-locked oscillator. The PLL provides frequency tuning of the 60-GHz voltage-controlled oscillator (VCO) using replica tuning. A pulse train is generated using a novel passive delay-locked loop and a CMOS pulse generator. This pulse train is then used for filtering the phase noise of 60-GHz VCO up to a high offset frequency. The total power consumption of the frequency synthesizer is 57 mW with a 1.2-V power supply.
Berkeley Lab Scientist Co-Leads Breast Cancer Dream Team (2009)

An $16.5 million, three-year grant to develop new and more effective therapies to fight breast cancer was awarded today to a multi-institutional Dream Team of scientists and clinicians that is co-led by Joe Gray, a renowned cancer researcher with the U.S. Department of Energys Lawrence Berkeley National Laboratory. http://newscenter.lbl.gov/
Characterization of antipsychotic medications, amino acid signatures, and platelet-activating factor in first-episode psychosis (2021)

First-episode psychosis refers to individuals early in the course of psychotic illness. Identifying the underlying biological processes, including biomarkers, is essential for improving diagnosis and treatment. We performed metabolomics profiling of plasma from a group of first-episode psychosis patients and matched neurotypical controls. Using global metabolomics profiling, we identified antipsychotic or antidepressant medication in 22 individuals diagnosed with first-episode psychosis, closely matching the drug prescription history. There were significant differences in levels of amino acids or their derivatives, including decreases in DL-arginine, L-histidine, DL-serine and threonine as well as increases in L-glutamic acid, ornithine, and proline. Using targeted metabolomics profiling of 408 compounds in plasma samples we identified significant differences in six compounds including decreases in serotonin and arginine as well as increased levels of sarcosine, proline, cis-4-hydroxyproline and trans-4-hydroxyproline. Platelet-activating factor levels were significantly elevated in the FEP cohort. These findings suggest potential biomarkers that require validation in independent cohorts, and in several cases provide supporting evidence for previously reported observations.
Correlates of Nontransmission in US Women at High Risk of Human Immunodeficiency Virus Type 1 Infection through Sexual Exposure (2002)

Seventeen women who were persistently uninfected by human immunodeficiency virus type 1 (HIV-1), despite repeated sexual exposure, and 12 of their HIV-positive male partners were studied for antiviral correlates of non-transmission. Thirteen women had > or = 1 immune response in the form of CD8 cell noncytotoxic HIV-1 suppressive activity, proliferative CD4 cell response to HIV antigens, CD8 cell production of macrophage inflammatory protein-1 beta, or ELISPOT assay for HIV-1-specific interferon-gamma secretion. The male HIV-positive partners without AIDS had extremely high CD8 cell counts. All 8 male partners evaluated showed CD8 cell-related cytotoxic HIV suppressive activity. Reduced CD4 cell susceptibility to infection, neutralizing antibody, single-cell cytokine production, and local antibody in the women played no apparent protective role. These observations suggest that the primary protective factor is CD8 cell activity in both the HIV-positive donor and the HIV-negative partner. These findings have substantial implications for vaccine development.
Autoantibody Production by Human B Lymphocytes which Spontaneously Proliferate (1987)

The ability of spontaneously proliferating lymphocytes to produce autoantibodies was examined. Peripheral blood lymphocytes from autoimmune patients and normal individuals were maintained in culture. In many cases lymphocytes grew spontaneously resulting in stable cell lines. Most of the cell lines secreted immunoglobulins. Supernatants were tested for the presence of autoantibodies by screening against normal tissues. Autoantibodies were present in supernatants derived from cells cultured from both autoimmune and normal individuals.
A Microfluidic Diluter Based on Pulse Width Flow Modulation (2009)

We demonstrate that pulse width flow modulation (PWFM) can be used to design fast, accurate, and precise multistage dilution modules for microfluidic devices. The PWFM stage unit presented here yields 10-fold dilution, but several PWFM stages can be connected in series to yield higher-order dilutions. We have combined two stages in a device thus capable of diluting up to 100-fold, and we have experimentally determined a set of rules that can be conveniently utilized to design multistage diluters. Microfabrication with resist-based molds yielded geometrical channel height variances of 7% (22.9(16) μm) with corresponding hydraulic resistance variances of ∼20%. Pulsing frequencies, channel lengths, and flow pressures can be chosen within a wide range to establish the desired diluter properties. Finally, we illustrate the benefits of on-chip dilution in an example application where we investigate the effect of the Ca&lt;sup&gt;2+&lt;/sup&gt; concentration on a phospholipid bilayer spreading from a membrane reservoir onto a SiO&lt;sub&gt;2&lt;/sub&gt; surface. This is one of many possible applications where flexible concentration control is desirable.
Prevention of Acute Inducible Atrial Flutter in Dogs by Using an Ibutilide-Polymer-Coated Pacing Electrode (1998)

Atrial arrhythmias (atrial fibrillation or atrial flutter) after coronary artery bypass graft surgery are difficult to prevent or treat and often result in significant morbidity. Prior experimental studies by our group showed improved therapeutic efficacy for antiarrhythmic drugs delivered via controlled-release polymeric matrices implanted on the epicardial surface. These experiments were conducted to test the hypothesis that direct atrial epicardial administration of ibutilide from a controlled-release system (compared with intravenous administration) can reduce the inducibility of atrial flutter in the acute postoperative atrial myocardium. Polymeric sustained-release preparations were formulated by solvent casting of an ibutilide and polyurethane (Pellathane) solution in tetrahydrofurane. Multilayer solvent-casted coatings on pacing electrode wires were carried out to fabricate a sustained-release electrode system. In animal model studies, each dog underwent a thoracotomy, followed by a right atriotomy that was repaired. Induction of atrial flutter was attempted by burst pacing with the bipolar pacing catheter. Sinus rhythm was restored with overdrive pacing. After determining the induction rate (percentage) of atrial flutter in the baseline state, a stainless-steel wire coated with the drug-delivery system, 10% ibutilide/90% polyurethane (n = 7), or without drug (polyurethane coating without ibutilide, n = 5; control) was sewn onto the right atrium. Systemic intravenous administration of ibutilide (1.2 microg/kg/h) also was carried out in a separate group of animals after atriotomy (n = 5). For ibutilide (at an estimated dose of 1.2 microg/kg/h), the atrial-flutter results were 41.85 +/- 2.21% induction for baseline compared with 12.42 +/- 5.26% (p = 0.02) after the ibutilide wire implant. In the control dogs, atrial flutter was induced 29.4 +/- 4.7% at baseline and 25.2 +/- 5.1% after implantation of the control wire (p = 0.4). Ibutilide coronary venous serum concentrations at the end of the ibutilide-polyurethane electrode experiments were 2.25 +/- 0.2 ng/ml (mean +/- SEM) versus systemic levels that were below the limits of detection. Systemic intravenous ibutilide infusions had no effect on the inducibility of atrial flutter. In conclusion, an epicardial implantable electrode coating with an ibutilide controlled drug-release system significantly reduced the inducibility of atrial flutter in an experimental atriotomy model. These results suggest that atrial arrhythmias occurring after coronary bypass surgery may be prevented by local atrial administration of ibutilide from a controlled-release pacing electrode.
Supplementary Table S1.3 from Metabolic and Functional Genomic Studies Identify Deoxythymidylate Kinase as a Target in <i>LKB1</i>-Mutant Lung Cancer (2023)

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