gebhart/patrepeval huggingface dataset:
Politics of Reading: Cultural Politics of Homelessness (2000)

Reading opens up important avenues for political action. Reading is political in the sense that social groups produce and resist, advance and censor readings of key cultural texts, according to their power to do so and their interests in doing so. This paper examines the politics of reading in relation to cultural politics of homeless‐ness. It does so by considering readers and readings of Johnny Go Home (1975), a British television documentary drama about homeless young people, and a cultural text that was open to different readings and political uses. Like many other representations of homeless people, Johnny Go Home revolved around a small number of stereotypes. However, these stereotypes were interpreted and used differently by different readers, according to their power to read and their interests in doing so. Broadly distinct interpretive communities, identified as liberal and conservative, used their respective readings of the programme to advance different solutions to contemporary homelessness. These readings were put to significant legislative use,for they were mobilised in the formal and informal political discourse that culminated in Britain's first direct legislation on behalf of homeless people. More generally, the various readings of Johnny Go Home underline the political significance of the consumption, as well as the production, of representations.
Supplementary Figure 1 from Evaluation and Clinical Analyses of Downstream Targets of the Akt Inhibitor GDC-0068 (2023)

&lt;p&gt;PDF file 285K, Biomarker validation by Western blot&lt;/p&gt;
Gene therapy in combination with tissue engineering to treat epidermolysis bullosa (2006)

In the last 20 years epidermal stem cells have been extensively used for tissue regeneration of epidermis and other epithelial surfaces. The tremendous progress achieved has led to the development of protocols aimed at the correction of rare genetic disorders such as epidermolysis bullosa (EB), a severe, often lethal, blistering disorder of the skin. Approximately 400,000-500,000 people are affected worldwide and no definitive treatments have yet been developed. Gene therapy might represent an alternative therapeutic approach. This paper reviews the different strategies used to genetically modify keratinocytes from EB patients and addresses issues such as the use of in vivo or ex vivo approaches, how to target keratinocytes with stem cell properties in order to have long-term therapeutic gene expression, and which gene transfer agents should be used. The progress made has led the authors' group to submit a request for a Phase I/II ex vivo therapy clinical trial for patients with junctional EB.
Localized Plasmon Field Effect of Gold Clusters Embedded in Nanoporous Silicon (2021)

Abstract Coupling between nanoplasmonics and semiconducting materials can enhance and complement the efficiency of almost all semiconductor technologies. It has been demonstrated that such composites enhance the light coupling to nanowires, increase photocurrent in detectors, enable sub‐gap detection, allow DNA detection, and produce large non‐linearity. Nevertheless, the tailored fabrication using the conventional methods to produce such composites remains a formidable challenge. This work attempts to resolve that deficiency by deploying the immersion‐plating method to spontaneously grown gold clusters inside nano‐porous silicon (np‐Si). This method allows the fabrication of thin films of np‐Si with embedded gold nanoparticles (Au) and creates nanoplasmonic–semiconductor composites, np‐Si/Au, with fractional volume between 0.02 and 0.13 of the metallic component. Optical scattering measurements reveal a distinctive, 200 nm broad, localized surface plasmon (LSP) resonance, centered around 700 nm. Linear and non‐linear properties, and their time evolution are investigated by optically pumping the LSP resonance and probing the optical response with short wavelength infra‐red (2.5 m) light. The ultrafast time‐resolved study demonstrates unambiguously that the non‐linear response is not only directly related to the LSP excitation, but strongly enhanced with respect to bare np‐Si, while its strength can be tuned by varying the metallic component.
supplementary information from Visualization of Breast Cancer Metabolism Using Multimodal Nonlinear Optical Microscopy of Cellular Lipids and Redox State (2023)

&lt;p&gt;additional experiment results, table and figures.&lt;/p&gt;
P01.152 Evaluation of Factor V Leiden variant as risk a factor for venous thromboembolism in glioblastoma patients (2018)

Venous thromboembolic events (VTE) are common complications in patients with glioblastoma (GBM). Factor V Leiden (FVL) polymorphism (rs6025, c.1601 G>A) is a known risk factor for VTE, evaluated in cancer associated thrombosis (CAT) in different tumor types. Little is known about the role of this variant in development of CAT in patients with GBM. A cohort of 116 GBM patients (73 males and 43 females) all treated with concomitant temozolomide and radiotherapy, were genotyped for FVL using PCR- pyrosequencing. Of the cohort, 40 patients were diagnosed with and 76 without VTE. Allele frequencies of respective variant were also compared with data from the SweGen Variant Frequency Browser (https://swegen-exac.nbis.se/). Statistical analyses in regard to VTE and its association with FVL and prognostic factors were performed. The variant A/G of FVL was carried by 17 (15%) of the patients and 99 (85%) were wild type, G/G. Chi2 test including the prognostic factors age, type of surgery, gender and blood group showed that these were evenly distributed between those with G/G and A/G, except for blood group in relation to FVL variant, which showed a borderline significance (p=0.07). Among the patients having blood group 0, 32% (n= 32) were G/G and 59% (n= 10) were A/G. Statistical tests did not reveal any correlation between blood group and FVL variant. In the logistic regression analysis apart from FVL, age, gender and blood group were included. This showed a significant difference for blood group 0 versus non-0 (A, B or AB) for decreased risk of VTE (P=0.014). There was no significant difference between heterozygous FVL (A/G) versus the G/G genotype in VTE risk (p=0.09). There were no differences in survival in relation to VTE or not or variant of FVL. The FVL AG variant is slightly overrepresented among GBM compared to the normal Swedish population, but does not reach statistical significance, OR 1.63 (0.93–2.84). We examined the influence of FVL variants together with clinical factors in a homogenously treated cohort of GBM patients for the risk to develop a VTE. We confirmed blood group 0 versus non-0 as reducing the VTE risk. For FVL c.1601 G>A variant, the differences between AG vs GG did not reach statistical significance. In our cohort we found a trend towards increased risk of developing GBM for the A/G variant. We plan to further study other factors involved in coagulation for their potential role in GBM patients.
End-to-Side Anastomosis Using a New Sutureless Vascular Prosthesis (2001)

Performing a conventional vascular anastomosis during minimally invasive surgery remains a technically difficult and time-consuming task. The purpose of our study was to assess the efficacy of a new sutureless vascular prosthesis. Through a left thoracotomy, a short segment of the descending aorta was bypassed in eight sheep. Our Dacron prosthesis had a cuff at one extremity. The cuff was introduced into the artery through an arteriotomy and attached to the arterial wall with clips. Surgery was performed on the sheep again 12-15 weeks later, and the prosthesis was retrieved for macroscopic and microscopic examination. At surgery, insertion of the prosthesis was easy, fast, and safe. A 3-4 mm space between each clip was required for proper attachment. At the second surgery, all prostheses were completely patent and there were no anastomotic stenoses or aneurysms. This new sutureless vascular prosthesis was easy and safe in its placement and might prove useful for video assisted vascular aortic surgery.
Fabrication of poly-Si/Au nano-gaps using atomic-layer-deposited Al2O3as a sacrificial layer (2005)

We propose a new process of fabricating nano-gap electrode pairs using an atomic-layer-deposited (ALD) thin film as a sacrificial layer. In this technique, we can control the width of a gap precisely by varying the number of deposition cycles of the ALD layer, and produce many identical gaps simultaneously. Using ALD Al2O3 as a sacrificial layer, we have fabricated poly-Si/Au nano-gaps of 10 nm width successfully. This new approach can provide a useful tool for the massive production of integrated molecular device circuits.
Microwave Synthesis of Core−Shell Gold/Palladium Bimetallic Nanoparticles (2004)

The microwave-assisted polyol reduction method was applied to the synthesis of core-shell gold/palladium bimetallic nanoparticles by the simultaneous reduction of the AuIII and PdII ions. The thickness of the palladium shell was calculated to be approximately 3 nm, and the gold core diameter is 9 nm. The structure and composition of the bimetallic particles were characterized by high-resolution transmission electron microscopy equipped with a nanoarea energy-dispersive X-ray spectroscopy attachment, transmission electron microscopy, X-ray diffraction, and X-ray photoelectron spectroscopy.
Bcl-xL Antisense Oligonucleotides Chemosensitize Human Glioblastoma Cells (2002)

Combination treatment using Bcl-xL antisense oligonucleotides and paclitaxel may qualify as a promising strategy to ultimately improve the clinical outcome of glioblastoma.
Wavelength Adjustment of Upstream Signal using AMCC with Power Monitoring for WDM-PON in 5G Mobile Era (2018)

We propose the wavelength adjustment method of the upstream signal using the AMCC complied with G.989.3 against the wavelength drift in WDM-PON and demonstrate it in the evaluation platform implementing the AMCC processor.
Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker (2017)

Inhibition of neuronal nitric oxide synthase (nNOS) is a promising therapeutic approach to treat neurodegenerative diseases. Recently, we have achieved considerable progress in improving the potency and isoform selectivity of human nNOS inhibitors bearing a 2-aminopyridine scaffold. However, these inhibitors still suffered from too low cell membrane permeability to enter into CNS drug development. We report herein our studies to improve permeability of nNOS inhibitors as measured by both PAMPA-BBB and Caco-2 assays. The most permeable compound (12) in this study still preserves excellent potency with human nNOS (K<sub>i</sub> = 30 nM) and very high selectivity over other NOS isoforms, especially human eNOS (hnNOS/heNOS = 2799, the highest hnNOS/heNOS ratio we have obtained to date). X-ray crystallographic analysis reveals that 12 adopts a similar binding mode in both rat and human nNOS, in which the 2-aminopyridine and the fluorobenzene linker form crucial hydrogen bonds with glutamate and tyrosine residues, respectively.
Rubber Emissivity and the Thermal State of Tires (1979)

Abstract An experimental procedure is described for obtaining accurate values of emissivity for materials of low thermal conductivity such as rubber. This procedure is then used to obtain data for the emissivity of tire tread, white sidewall, black sidewall, and inner‐liner surfaces. The significance of these results to infrared (IR) temperature measurement and to the analytical modeling of the thermal state of a tire is discussed.
Compositional verification of an ATM switch module using interface recognizer/suppliers (IRS) (2002)

We propose an approach to compositional verification of complex systems based on the interactions at the interfaces of the components. Interactions at an interface are first recognized by a finite automaton called interface recognizer/supplier (IRS). Programming IRS as supplier of the interactions allows us to simulate inter-actions of one side of the interface while model checking the other side. We formulate the composition rule and illustrate the method on an ATM switch module.
MP40-16 RISK FACTORS OF BIOCHEMICAL RECURRENCE IN LOCALLY ADVANCED PROSTATE CANCER PATIENTS WITH PREOPERATIVE GLEASON GRADE OF 4 OR 5 AFTER ROBOT-ASSISTED RADICAL PROSTATECTOMY (2016)

ORP. However, ORP was associated with advanced PCa than RARP in resection margin, pathologic tumor volume, clinical and pathologic T stage (P<0.049). A multivariate Cox proportional hazards model for BCR showed that preoperative PSA (HR1.007, p0.010), RALP (vs. ORP, HR1.115, p0.057), Gleason score ( 8, HR3.996, p<0.001) were significant predictors.
Pixel-based pipeline hardware architecture for high-performance Haar-like feature extraction (2016)

Feature extraction, which is one of the basic tasks for pattern recognition, has often high computational cost and large memory usage. In this work, we propose a pixel-based pipeline hardware architecture for Haar-like feature extraction, implemented in 0.18 μm CMOS technology with 1.76 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> core area. Pixel-input speed relies on the working frequency of the image sensor so that features are extracted in real time without on-chip image buffer and complex computational procedures. The fabricated chip consumes 4.78 mW power at 1.8 V supply voltage and 12.5 MHz frequency during 30 fps VGA video input. Furthermore, a processing time of 3.07 ms per VGA frame with power dissipation of 36.25 mW at 100 MHz frequency is possible.
Robust Performance Enhancement Using Disturbance Observers for Hysteresis Compensation Based on Generalized Prandtl–Ishlinskii Model (2013)

This paper presents an approach employing disturbance observers to enhance the performance of inverse-based hysteresis compensation based on the generalized Prandtl–Ishlinskii model in feedback control reference-tracking applications. It is first shown that the error resulting from inexact hysteresis compensation is an L∞-bounded signal. Hence, a disturbance observer (DOB) is designed to cancel its effect and improve the closed loop robust tracking performance in the presence of plant dynamics uncertainty. The design of the DOB makes use of an equivalent internal model-based estimation of exogenous disturbances, where the internal model dynamics is designed to have at least an eigenvalue at the origin. The synthesis is then formulated as an H∞ weighted-sensitivity optimization for static output feedback (SOF) gain of a Luenberger observer. A linearization heuristic is then implemented to solve the bilinear-matrix-inequality (BMI) constrained semidefinite program (SDP) for a (sub)optimal static gain. Simulation results indicate that tracking performance is indeed improved using the combined inversion-based compensation and the DOB.
Ultrasound imaging and contrast agents: A safe alternative to MRI? (2006)

Microbubble contrast media are used to enhance ultrasound images. Because ultrasound is a real-time investigation, contrast-enhanced ultrasound offers possibilities for perfusion imaging. This review is conducted to evaluate the safety of contrast-enhanced ultrasound and its possible role in medical imaging. The safety of diagnostic ultrasound is still an important field of research. The wanted and unwanted effects of ultrasound and microbubble contrast media as well as the effects of ultrasound on these microbubbles are described. Furthermore, some of the possible applications and indications of contrast-enhanced ultrasound will be discussed. The shared advantages of MRI and ultrasound are the use of non-ionizing radiation and non-nephrotoxic contrast media. From this review it can be concluded that, for certain indications, contrast enhanced ultrasound could be a safe alternative to MRI and a valuable addition to medical imaging.
Genes of the Renin-Angiotensin System and the Genetics of Human Hypertension (2018)

Despite intensive investigation of the physiology of blood pressure regulation, the primary abnormalities contributing to the pathogenesis of this common disorder remain unknown in the overwhelming majority of patients. An alternative approach to pure physiologic analysis would be to identify mutations contributing to the pathogenesis of hypertension. Since such genetic abnormalities cannot be simply a consequence of hypertension, their identification should provide a useful starting point from which to elucidate pathophysiology. Aldosterone synthase is normally expressed only in the adrenal glomerulosa, where it catalyzes the final two steps in the biosynthesis of aldosterone from corticosterone. Genetic approaches to hypertension remain in their infancy. Only a few loci have been carefully studied in hypertensive subjects; even within the renin-angiotensin system, linkage studies with the angiotensin and angiotensin II receptor genes have not as yet been performed. No inference regarding populations of different ethnic and racial backgrounds can be made.
GCN-Based Structure-Activity Relationship and DFT Studies of Staphylococcus aureus FabI Inhibitors (2022)

The enoyl-[acyl-carrier-protein] reductase (FabI) is an important enzyme in the fatty acid metabolism of Gram-positive bacteria, such as Staphylococcus aureus. FabI is also a potential target for the development of novel antibacterials. Several machine learning-driven studies were reported to develop FabI inhibitors, describing robust and predictive models. Herein, the authors applied the kGCN, a graph convolutional network framework, to generate classification models to select potential S. aureus FabI inhibitors. The most predictive model showed robustness for both active and inactive class prediction, according to statistical validation. Finally, the chemical interpretation of the model was consistent with prior experimental and theoretical works. The SAR analysis highlighted the importance of the occupation of hydrophobic pockets and polar interactions with Tyr-156 and NADPH cofactor present in the FabI catalytic site by potential inhibitors. A density functional theory study endorsed the SAR, where the electrostatic surfaces were consistent with the expected interactions with the pocket.
A 1 Tb/s 3 W Inductive-Coupling Transceiver for 3D-Stacked Inter-Chip Clock and Data Link (2007)

A 1 Tb/s 3 W inter-chip transceiver transmits clock and data by inductive coupling at a clock rate of 1 GHz and data rate of 1 Gb/s per channel. 1024 data transceivers are arranged with a pitch of 30 mum in a layout area of 1 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . The total layout area including 16 clock transceivers is 2 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> in 0.18 mum CMOS and the chip thickness is reduced to 10 mum. Bi-phase modulation (BPM) is employed for the data link to improve noise immunity, reducing power in the transceiver. Four-phase time division multiple access (TDMA) reduces crosstalk and the bit-error rate (BER) is lower than 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-13</sup>
Design and implementation of an inverter output LC filter used for dv/dt reduction (1999)

This paper presents the design and analysis of a LC output filter for use with IGBT-based motor drive inverters. The LC filter is used to limit the rate of rise of the inverter output voltage and reduce common mode noise to the motor. In typical applications where dv/dt is limited to 100-500 V//spl mu/sec, the resonant frequency of the filter is above the switching frequency. A diode bridge must therefore be used to clamp the resonant voltage. Resistors are also used to help dissipate the energy stored in the resonant circuit. Crucial to the design of the filter is the handling of the additional losses in the filter. The paper describes the design considerations for such a filter for use in a 460 V induction motor drive. The losses in each of the elements are estimated to show the limitations of the filter. Experimental results illustrate the control of dv/dt at the inverter terminals, and the reduced peak voltage at the motor end of a long cable.
ChemInform Abstract: Synthesis of Dihydro‐1,4‐oxathiins by Rearrangement of 1,3‐Oxathiolane Sulfoxides. (1987)

Abstract The oxathiolanes (I) are oxidized to produce mixtures of cis‐(II) and trans‐sulfoxides (III) which rearrange on treatment with acids in the presence of DMF to yield the oxathiins (IV).
Dynamics of Centrifugal Compression Systems (2013)

Compression systems employed in gas processing plants and in gas pipeline transmission systems provide vital function to the overall operation of both systems, and therefore, must be vigilantly attended to in order to ensure a high level of operational reliability. The majority of these compression systems employ centrifugal compressors, either single- or multi-staged, driven by either gas turbines or electric motors with/without gearboxes. These compression systems are required to not only withstand uninterrupted operation for extended periods of time but also be able to cope with flow and pressure transients associated with surge control, startup and emergency shutdown (ESD) [1–8]. During these transients, the centrifugal compressors interact dynamically with system components around them, i.e. piping, fittings and equipment, drivers, as well as the associated control protocols. Fluid inertias and compressor/driver rotor inertias play an important role in either stabilizing or destabilizing the system dynamics [9]. The compressors' performance characteristics have also an important role in the system dynamics behaviour [10]. Ensuring reliable and safe operation of the various aspects of these compression systems requires a good understanding of their dynamic behavior, which enables sound system design, operation and control.
Overcoming Data Sparsity in Automatic Transcription of Dictated Medical Findings (2022)

This paper presents a method for introducing class n-gram language models as a means for overcoming data sparsity in the training of an automatic speech recognition (ASR) system aimed at transcription of dictated medical findings composed predominantly in the Serbian language, including occasional phrases in Latin. The classes used by the model are defined with the specific aim of avoiding the need of identifying an appropriate orthographic expansion of each abbreviation, number or other non-orthographic element in a particular context. Generated language models are decoded in Kaldi using token passing, and lattices generated in this way are rescored using recurrent neural network language models (RNNLM). Although the proposed approach requires extensive effort for initial definition of classes based on existing text corpora of medical findings, it improves the quality of the model and increases the degree of automation in the processing of future training corpora. As such, the proposed method is particularly suitable for training on noisy data, full of misspel-lings and other errors, such as medical findings. The feasibility of the approach has been tested on a corpus of medical findings in the domain of radiology, where a perplexity score of 59.55 and word error rate of 1.4% have been achieved.