gebhart/patrepeval huggingface dataset:
High power 4H-SiC thyristors (2002)

For very high voltage, high current devices (>3 kV, >100 A), the use of bipolar SiC devices will be required because of their much higher current densities. These devices have applications in the area of traction control and power transmission. In this report, higher voltage and higher current npnp 4H-SiC thyristors have been achieved. The npnp device is the most promising thyristor structure to date because it allows the use of a low resistivity n-type substrate. A mesa structure was utilized, with all of the doping being done in situ during epitaxy. The device periphery was terminated using a reactive ion etched mesa, and the gate was contacted by performing a trench etch, again with reactive ion etching.
Gallane/phosphine adducts: air-stable H3Ga.cntdot.P(C6H11)3 and gallane rich 2H3Ga.cntdot.(PMe2CH2)2 (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGallane/phosphine adducts: air-stable H3Ga.cntdot.P(C6H11)3 and gallane rich 2H3Ga.cntdot.(PMe2CH2)2Jerry L. Atwood, Frederick R. Bennett, Fiona M. Elms, George A. Koutsantonis, Colin L. Raston, Kerry D. Robinson, and David J. YoungCite this: Inorg. Chem. 1992, 31, 13, 2673–2674Publication Date (Print):June 1, 1992Publication History Published online1 May 2002Published inissue 1 June 1992https://pubs.acs.org/doi/10.1021/ic00039a001https://doi.org/10.1021/ic00039a001research-articleACS PublicationsRequest reuse permissionsArticle Views127Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Genome-wide association study identifies 48 common genetic variants associated with handedness (2019)

Abstract Handedness, a consistent asymmetry in skill or use of the hands, has been studied extensively because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and 32 studies from the International Handedness Consortium, we conducted the world’s largest genome-wide association study of handedness (1,534,836 right-handed, 194,198 (11.0%) left-handed and 37,637 (2.1%) ambidextrous individuals). We found 41 genetic loci associated with left-handedness and seven associated with ambidexterity at genome-wide levels of significance (P &lt; 5×10 −8 ). Tissue enrichment analysis implicated the central nervous system and brain tissues including the hippocampus and cerebrum in the etiology of left-handedness. Pathways including regulation of microtubules, neurogenesis, axonogenesis and hippocampus morphology were also highlighted. We found suggestive positive genetic correlations between being left-handed and some neuropsychiatric traits including schizophrenia and bipolar disorder. SNP heritability analyses indicated that additive genetic effects of genotyped variants explained 5.9% (95% CI = 5.8% – 6.0%) of the underlying liability of being left-handed, while the narrow sense heritability was estimated at 12% (95% CI = 7.2% – 17.7%). Further, we show that genetic correlation between left-handedness and ambidexterity is low (r g = 0.26; 95% CI = 0.08 – 0.43) implying that these traits are largely influenced by different genetic mechanisms. In conclusion, our findings suggest that handedness, like many other complex traits is highly polygenic, and that the genetic variants that predispose to left-handedness may underlie part of the association with some psychiatric disorders that has been observed in multiple observational studies.
Prefilter design for low-complexity equalization of MIMO systems (2005)

We focus on the problem of reduced complexity equalization of multi-input, multi-output (MIMO) systems. In particular, we look at a prefilter design that enables the use of methods such as decision feedback sequence estimation (DFSE) while minimizing the effects of error propagation. We show that a well-known spectral factorization approach can be used to obtain a minimum-phase MIMO prefilter that performs energy compaction well, and thus provides a suitable prefilter. Through simulations on a MIMO system, we compare the performance of the minimum-phase MIMO prefilter with other prefilter approaches that have been published in literature, such as the minimum-mean-square (MMSE) and channel shortening prefilters. The minimum-phase MIMO prefilter outperforms the published approaches. In addition, the minimum-phase MIMO prefilter is less complex to compute.
The protein phosphatases involved in cellular regulation. Glycolysis, gluconeogenesis and aromatic amino acid breakdown in rat liver (1984)

The identities of the protein phosphatases involved in the regulation of hepatic glycolysis, gluconeogenesis and aromatic amino acid breakdown were investigated using 6-phosphofructo-1-kinase, fructose-1,6-bisphosphatase, L-pyruvate kinase, phenylalanine hydroxylase and the bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as substrates. Purified preparations of protein phosphatases-1, 2A, 2B and 2C exhibited activity towards all five substrates in vitro, although phosphatases-1 and 2B were only weakly active. Studies in liver extracts using inhibitor-2 and trifluoperazine, which inhibit protein phosphatase-1 and 2B, respectively, confirmed that these phosphatases are unlikely to be important in dephosphorylating these substrates in vivo. Sequential fractionation of rat liver extracts by anion-exchange chromatography and gel-filtration failed to resolve any protein phosphatases acting on each substrate, apart from protein phosphatases-2A and 2C. The present results, together with those described in the following paper (in this journal) indicate that under the assay conditions used, protein phosphatase-2A is the most powerful phosphatase acting on each substrate, although protein phosphatase-2C contributes a significant percentage of the activity towards 6-phosphofructo-1-kinase. No clear evidence was obtained for a role of metabolites in the regulation of dephosphorylation of the five substrates. This study reinforces our contention that only a few serine-specific and threonine-specific protein phosphatase catalytic subunits participate in cellular regulation.
Quantitative Monitoring of BCR / ABL Transcript During STI-571 Therapy (2002)

PCR for the BCR/ABL fusion transcript provides a highly sensitive and specific method for detecting minimal residual disease in patients with chronic myeloid leukemia (CML). We sought to determine if quantitative PCR measurement of peripheral blood BCR/ABL transcript can be used to monitor response in CML patients with clinically evident disease while receiving the protein tyrosine kinase inhibitor STI-571. Serial bone marrow cytogenetics and peripheral blood BCR/ABL mRNA levels were measured in 17 patients [9 with chronic phase (CP) and 8 with accelerated phase or blast crisis (AP/BC)] during 1 year of treatment. Overall, quantitative PCR BCR/ABL transcript level decreased by a median of 0.9 log during the first 3 months, and by 1.6 logs by 12 months. Among cytogenetic responders (6 CP and 2 AP/BC), median BCR/ABL copy number was 0.9 and 2.1 logs lower than baseline after 3 and 12 months of treatment, respectively. No patient became PCR-negative for BCR/ABL. Among cytogenetic non-responders, BCR/ABL transcript level decreased by 0.4 logs after 3 months, with no subsequent reductions. At study entry, BCR/ABL expression in cytogenetic responders and non-responders was similar. However, BCR/ABL expression became significantly different 3 months after treatment (p = 0.02), and increasingly different with continued therapy (p = 0.04, 0.005, 0.0008 at 6, 9 and 12 months, respectively). Our results demonstrate that PBMC BCR/ABL mRNA levels correlate well with response to STI-571. This non-invasive, rapid and sensitive PCR-based assay can be used to monitor response to STI-571.
Discovery of a Novel Pharmacological and Structural Class of Gamma Secretase Modulators Derived from the Extract of Actaea racemosa (2012)

A screen of a library of synthetic drugs and natural product extracts identified a botanical extract that modulates the processing of amyloid precursor protein (APP) in cultured cells to produce a lowered ratio of amyloid-beta peptide (1-42) (Aβ42) relative to Aβ40. This profile is of interest as a potential treatment for Alzheimer's disease. The extract, from the black cohosh plant (Actaea racemosa), was subjected to bioassay guided fractionation to isolate active components. Using a combination of normal-phase and reverse-phase chromatography, a novel triterpene monoglycoside, 1, was isolated. This compound was found to have an IC(50) of 100 nM for selectively reducing the production of amyloidogenic Aβ42 while having a much smaller effect on the production of Aβ40 (IC(50) 6.3 μM) in cultured cells overexpressing APP. Using IP-MS methods, this compound was found to modulate the pool of total Aβ produced by reducing the proportion of Aβ42 while increasing the relative amounts of shorter and less amyloidogenic Aβ37 and Aβ39. Concentrations of 1 sufficient to lower levels of Aβ42 substantially (up to 10 μM) did not significantly affect the processing of Notch or other aspects of APP processing. When 1 (10 μg) was administered to CD-1 normal mice intracerebroventricularly, the level of Aβ42 in brain was reduced. Assays for off-target pharmacology and the absence of overt signs of toxicity in mice dosed with compound 1 suggest a comparatively selective pharmacology for this triterpenoid. Compound 1 represents a new lead for the development of potential treatments for Alzheimer's disease via modulation of gamma-secretase.
Genome-wide association study identifies multiple loci influencing human serum metabolite levels (2012)

Nuclear magnetic resonance assays allow for measurement of a wide range of metabolic phenotypes. We report here the results of a GWAS on 8,330 Finnish individuals genotyped and imputed at 7.7 million SNPs for a range of 216 serum metabolic phenotypes assessed by NMR of serum samples. We identified significant associations (P &amp;lt; 2.31 × 10(-10)) at 31 loci, including 11 for which there have not been previous reports of associations to a metabolic trait or disorder. Analyses of Finnish twin pairs suggested that the metabolic measures reported here show higher heritability than comparable conventional metabolic phenotypes. In accordance with our expectations, SNPs at the 31 loci associated with individual metabolites account for a greater proportion of the genetic component of trait variance (up to 40%) than is typically observed for conventional serum metabolic phenotypes. The identification of such associations may provide substantial insight into cardiometabolic disorders.
Microstructure and Electrical Properties of PZT Thin films Deposited by Laser Ablation on Template Layer (2002)

Thin films of Pb(Zr 0.52 Ti 0.48 )O 3 (PZT) were prepared by pulsed laser deposition technique on Pt/Ti/SiO 2 /Si substrates using a template layer derived by sol-gel processing. Crystalline phases and microstructure of the PZT films were investigated by X-ray diffraction analysis and scanning electron microscopy, respectively. The use of the template layer favored the obtaining of (111) oriented crystalline PZT film with perovskite phase at relatively low temperature. Electrical properties of the films were evaluated by measuring their P-E hysteresis loops and dielectric constants. The PZT films fabricated by laser ablation on the template layer exhibited better ferroelectric properties than those derived directly on Pt/Ti/SiO 2 /Si. The remanent polarization and the coercive field of the film fabricated on the template layer and annealed at 650C were 31.28 w C/cm 2 and 45.29 kV/cm, while the dielectric constant and loss values measured at 1 kHz were approximately 1069 and 0.06, respectively.
STUDIES WITH TRIMIX GEL IN MEN WHO FAILED PHOSPHODIESTERASE INHIBITORS (2008)

You have accessJournal of Urology1 Apr 2008STUDIES WITH TRIMIX GEL IN MEN WHO FAILED PHOSPHODIESTERASE INHIBITORS Joel L Marmar, Thomas J Harkins, and John Riordan Joel L MarmarJoel L Marmar More articles by this author , Thomas J HarkinsThomas J Harkins More articles by this author , and John RiordanJohn Riordan More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(08)61264-1AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "STUDIES WITH TRIMIX GEL IN MEN WHO FAILED PHOSPHODIESTERASE INHIBITORS." The Journal of Urology, 179(4S), p. 431 © 2008 by American Urological AssociationFiguresReferencesRelatedDetails Volume 179Issue 4SApril 2008Page: 431 Advertisement Copyright & Permissions© 2008 by American Urological AssociationMetricsAuthor Information Joel L Marmar More articles by this author Thomas J Harkins More articles by this author John Riordan More articles by this author Expand All Advertisement PDF downloadLoading ...
Genome-Wide Array Analysis of Normal and Malformed Human Hearts (2003)

Our findings propose that array analysis of malformed human hearts opens a new window to understand the complex genetic network of cardiac development and adaptation. For detailed access, see the online-only Data Supplement.
Comparison of an Er: YAG laser osteotome versus a conventional drill for the use in osteo‐ odonto‐keratoprosthesis (OOKP) (2019)

The laser cut holes were as strong as bur-drilled holes, although SEM pictures showed a smoother surface of the laser cut holes. Hence, laser osteotomes open the possibility to custom fit the hole exactly to the width of the cylinder, which represents a potential advantage of the laser over the conventional bur. Lasers Surg. Med. 51:531-537, 2019. © 2019 Wiley Periodicals, Inc.
The Cormatrix Cor™ Patch for Epicardial Infarct Repair (2021)

Contemporary management of ischemic heart disease lacks strategies to directly access the heart and promote reparative cellular mechanisms to improve postinfarct cardiac remodeling. Epicardial infarct repair (EIR) is an emerging technique whereby bioactive materials are sewn over ischemic areas of the heart at the time of surgical revascularization to promote adaptive cardiac repair. The CorMatrix Cor™ PATCH (CorMatrix Cardiovascular Inc., GA, USA) is an acellular bioactive material compatible with EIR. Herein, we review current preclinical and clinical data for the CorMatrix Cor PATCH and its use in EIR.
Spotlight (2005)

We describe a new interaction technique, called a spotlight, for directing the visual attention of an audience when viewing data or presentations on large wall-sized displays. A spotlight is simply a region of the display where the contents are displayed normally while the remainder of the display is somewhat darkened. In this paper we define the behavior of spotlights, show unique affordances of the technique, and discuss design characteristics. We also report on experiments that show the benefit of using the spotlight a large display and standard desktop configuration. Our results suggest that the spotlight is preferred over the standard cursor and outperforms it by a factor of 3.4 on a wall-sized display.
Targeted detection of murine colonic dysplasia in vivo with flexible multispectral scanning fiber endoscopy (2012)

Gastrointestinal cancers are heterogeneous and can overexpress several protein targets that can be imaged simultaneously on endoscopy using multiple molecular probes. We aim to demonstrate a multispectral scanning fiber endoscope for wide-field fluorescence detection of colonic dysplasia. Excitation at 440, 532, and 635 nm is delivered into a single spiral scanning fiber, and fluorescence is collected by a ring of light-collecting optical fibers placed around the instrument periphery. Specific-binding peptides are selected with phage display technology using the CPC;Apc mouse model of spontaneous colonic dysplasia. Validation of peptide specificity is performed on flow cytometry and in vivo endoscopy. The peptides KCCFPAQ, AKPGYLS, and LTTHYKL are selected and labeled with 7-diethylaminocoumarin-3-carboxylic acid (DEAC), 5-carboxytetramethylrhodamine (TAMRA), and CF633, respectively. Separate droplets of KCCFPAQ-DEAC, AKPGYLS-TAMRA, and LTTHYKL-CF633 are distinguished at concentrations of 100 and 1 μM. Separate application of the fluorescent-labeled peptides demonstrate specific binding to colonic adenomas. The average target/background ratios are 1.71 ± 0.19 and 1.67 ± 0.12 for KCCFPAQ-DEAC and AKPGYLS-TAMRA, respectively. Administration of these two peptides together results in distinct binding patterns in the blue and green channels. Specific binding of two or more peptides can be distinguished in vivo using a novel multispectral endoscope to localize colonic dysplasia on real-time wide-field imaging.
Lazy constraints and SAT heuristics for proof-based abstraction (2005)

SAT proof analysis techniques have been used recently with BMC in order to generate proof-based abstractions that preserve the correctness of the property up to a certain depth. In this paper, we propose various techniques for handling BMC constraints that are targeted at reducing the size of the abstract model while preserving bounded correctness. We propose lazy constraints, where the idea is to delay propagation of certain implied values without modifying a standard SAT solver. We propose different methods for automatic use of lazy constraints in SAT-based BMC. Their use can be regarded as a heuristic, which typically leads to significant reduction in the size of the abstract model, frequently accompanied by an overall performance improvement. We also use SAT proof analysis to loosen the user-specified environmental constraints, in order to generate smaller abstract models for conservative verification. We briefly describe other SAT-based heuristics for reducing the size of the abstract model. We have implemented our techniques in a prototype verification platform, and demonstrate their effectiveness on several large industry designs.
Avalanche gain in InAs<sub>y</sub>P/sub 1-y/ (0.1<y<0.3) photodetectors (1995)

Uniform avalanche gains of 40 to 80 are observed in InAs/sub y/P/sub 1-y/ (0.1<y<0.3) grown on p-type InP substrates, with lattice strains as high as 1%. These devices have a primary dark current as low as 200 pA, with the dark current increasing, in some cases, to only 1 nA at 90% of the breakdown voltage. The ionization coefficients for both electrons and holes are approximately equal, and the generation of secondary carriers is primarily via ionization of defect levels. The InAs/sub yx/P/sub 1-y/ layers have the same lattice parameter as compositions of In/sub x/Ga/sub 1-x/ which absorb light wavelengths /spl les/2.1 &#x003BC;m, suggesting that this material combination has potential for use in avalanche photodiodes that detect moisture in LIDAR and gas-sensing applications in the mid-IR spectral range.
Synthesis, Cytotoxicity, and Anti-Trypanosoma cruzi Activity of New Chalcones (2008)

Synthesis of a cytotoxic dihydrochalcone, first isolated from a traditional Amazonian medicinal plant Iryanthera juruensis Warb (Myristicaceae), followed by a comprehensive SAR analysis of saturated and unsaturated chalcone synthetic intermediates, led to the identification of analogues with selective and significant in vitro anti- Trypanosoma cruzi activity. Further SAR studies were undertaken with the synthesis of 21 new chalcones containing two allyloxy moieties that resulted in the discovery of 2',4'-diallyloxy-6'-methoxy chalcones with improved selectivity against this parasite at concentrations below 25 microM, four of which exhibited a selectivity index greater than 12.
Improvements in a chemiluminescent ozone analyzer for respiratory applications (1990)

The performance characteristics of a previously developed analyzer utilizing the homogeneous chemiluminescent reaction of ozone (O3) with a stoichiometric excess of 2-methyl-2-butene were improved with the eventual goal of measuring the distribution of O3 in a single human breath. By increasing the sampling flow from 200 to 400 mℓ/min and utilizing a combination of analog and digital filtering, it was possible to improve the signal-to-noise ratio at 0.5 ppm O3 from 5.5 to 28, the minimum detection limit from 0.02 to 0.01 ppm, the sensitivity from 1.5 to 2.3 na/ppm, and the 10%–90% step-response time from 200 to 100 ms. Humidity, temperature, and inlet gas composition interferences were also evaluated. While temperature and humidity have no influence on the analyzer output, the substitution of carbon dioxide for oxygen increased the analyzer sensitivity by 3.8% for each percent of CO2 that was present. Thus, provided that an appropriate correction for carbon dioxide is made, these improvements allow the instrument to monitor inhaled and exhaled O3 concentrations with a rapid dynamic response and over a broad range of physiologically relevant values.
Supplementary Data from Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRAS<sup>G12C</sup> (2023)

Supplementary Data from Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRAS&lt;sup&gt;G12C&lt;/sup&gt;
Marine Bacteria. Part 25. Himalomycin A and B: Isolation and Structure Elucidation of New Fridamycin Type Antibiotics from a Marine Streptomyces Isolate. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Enhanced detection of neoantigen-reactive T cells targeting unique and shared oncogenes for personalized cancer immunotherapy (2018)

Adoptive cell transfer (ACT) of tumor-infiltrating lymphocytes (TILs) targeting neoantigens can mediate tumor regression in selected patients with metastatic epithelial cancer. However, effectively identifying and harnessing neoantigen-reactive T cells for patient treatment remains a challenge and it is unknown whether current methods to detect neoantigen-reactive T cells are missing potentially clinically relevant neoantigen reactivities. We thus investigated whether the detection of neoantigen-reactive TILs could be enhanced by enriching T cells that express PD-1 and/or T cell activation markers followed by microwell culturing to avoid overgrowth of nonreactive T cells. In 6 patients with metastatic epithelial cancer, this method led to the detection of CD4+ and CD8+ T cells targeting 18 and 1 neoantigens, respectively, compared with 6 and 2 neoantigens recognized by CD4+ and CD8+ T cells, respectively, when using our standard TIL fragment screening approach. In 2 patients, no recognition of mutated peptides was observed using our conventional screen, while our high-throughput approach led to the identification of 5 neoantigen-reactive T cell receptors (TCRs) against 5 different mutations from one patient and a highly potent MHC class II-restricted KRASG12V-reactive TCR from a second patient. In addition, in a metastatic tumor sample from a patient with serous ovarian cancer, we isolated 3 MHC class II-restricted TCRs targeting the TP53G245S hot-spot mutation. In conclusion, this approach provides a highly sensitive platform to isolate clinically relevant neoantigen-reactive T cells or their TCRs for cancer treatment.