gebhart/patrepeval huggingface dataset:
Unified Buffer: Compiling Image Processing and Machine Learning Applications to Push-Memory Accelerators (2022)

Image processing and machine learning applications benefit tremendously from hardware acceleration. Existing compilers target either FPGAs, which sacrifice power and performance for programmability, or ASICs, which become obsolete as applications change. Programmable domain-specific accelerators, such as coarse-grained reconfigurable arrays (CGRAs), have emerged as a promising middle-ground, but they have traditionally been difficult compiler targets since they use a different memory abstraction. In contrast to CPUs and GPUs, the memory hierarchies of domain-specific accelerators use push memories : memories that send input data streams to computation kernels or to higher or lower levels in the memory hierarchy and store the resulting output data streams. To address the compilation challenge caused by push memories, we propose that the representation of these memories in the compiler be altered to directly represent them by combining storage with address generation and control logic in a single structure—a unified buffer. The unified buffer abstraction enables the compiler to separate generic push memory optimizations from the mapping to specific memory implementations in the backend. This separation allows our compiler to map high-level Halide applications to different CGRA memory designs, including some with a ready-valid interface. The separation also opens the opportunity for optimizing push memory elements on reconfigurable arrays. Our optimized memory implementation, the Physical Unified Buffer, uses a wide-fetch, single-port SRAM macro with built-in address generation logic to implement a buffer with two read and two write ports. It is 18% smaller and consumes 31% less energy than a physical buffer implementation using a dual-port memory that only supports two ports. Finally, our system evaluation shows that enabling a compiler to support CGRAs leads to performance and energy benefits. Over a wide range of image processing and machine learning applications, our CGRA achieves 4.7× better runtime and 3.5× better energy-efficiency compared to an FPGA.
Validating impedance-based methodology for in vitro dynamic analysis of reagents and effector cells efficacy in cancer immunotherapy protocols (2016)

Abstract In vitro characterization of the efficacy of reagents for cancer immunotherapy is a necessary step before moving to more expensive animal models and clinical studies. However, current in vitro assays are difficult to implement in high throughput environment and are mainly based on end point methodologies that are unable to capture the full dynamic of the immune response. Here we present the adaptation of an impedance-based platform to monitoring cytotoxic activity of immune cells activated trough different means. The technology detects cell death and proliferation of adherent cells by measuring changes in conductance of microelectrodes embedded in 96 and 384-wells cell culture plates. We utilized adherent cell lines and primary tumor cells with different expression levels of the EpCAM antigen, which is currently under evaluation as a target for cancer immunotherapy. Using PBMCs and NK92 as effector cells and combinations of EpCAM/CD3 BiTE and anti-EpCAM antibodies, we demonstrated the suitability of the impedance-based approach to quantitatively monitor the efficacy of immune cells-mediated cancer cell killing both under different effector:target ratios and antibody concentrations. We also validated the same approach with suspension cells immobilized on the surface of the electrodes. Overall, our results demonstrate the value of such approach in measuring the cytotoxic response across the temporal scale, an aspect that is otherwise very difficult to assess with more canonical end point assays. Furthermore, the availability of 384-wells format and minimal sample handling place the technology in an ideal spot for applications in personalized medicine, like therapeutic protocol validation directly on patient samples.
Local Distortions in Nanostructured Ferroelectric Ceramics through Strain Tuning (2015)

Ferroelectric materials are highly sensitive to grain size reduction because strain and ferroelectric polarization have a direct connection. Using 15 nm (Ba,Sr)TiO 3 particles obtained by advanced supercritical synthesis and their densification by high‐pressure spark plasma sintering under air, reproducible and dense nanostructured ceramics are achieved. Taking advantage of the high pressure (up to 600 MPa) applied during the sintering step, the internal stress generated at the grain scale can be monitored to compensate for the particle surface stress due to size effect. Both the local dynamics observed by Raman scattering and the overall dielectric behavior consistently indicate a recovery of the ferroelectric properties as the sintering pressure is increased. This unique behavior shows that low‐temperature and high‐pressure processing enables designing nanostructured functional ceramics exhibiting original properties.
DECONVOLUTION OF IMAGES FROM BLAST 2005: INSIGHT INTO THE K3-50 AND IC 5146 STAR-FORMING REGIONS (2011)

We present an implementation of the iterative flux-conserving Lucy-Richardson (L-R) deconvolution method of image restoration for maps produced by the Balloon-borne Large Aperture Submillimeter Telescope (BLAST). Compared to the direct Fourier transform method of deconvolution, the L-R operation restores images with better-controlled background noise and increases source detectability. Intermediate iterated images are useful for studying extended diffuse structures, while the later iterations truly enhance point sources to near the designed diffraction limit of the telescope. The L-R method of deconvolution is efficient in resolving compact sources in crowded regions while simultaneously conserving their respective flux densities. We have analyzed its performance and convergence extensively through simulations and cross-correlations of the deconvolved images with available high-resolution maps. We present new science results from two BLAST surveys, in the Galactic regions K3-50 and IC 5146, further demonstrating the benefits of performing this deconvolution. We have resolved three clumps within a radius of 4'.5 inside the star-forming molecular cloud containing K3-50. Combining the well-resolved dust emission map with available multi-wavelength data, we have constrained the spectral energy distributions (SEDs) of five clumps to obtain masses (M), bolometric luminosities (L), and dust temperatures (T). The L-M diagram has been used as a diagnostic tool to estimate the evolutionary stages of the clumps. There are close relationships between dust continuum emission and both 21 cm radio continuum and ^(12)CO molecular line emission. The restored extended large-scale structures in the Northern Streamer of IC 5146 have a strong spatial correlation with both SCUBA and high-resolution extinction images. A dust temperature of 12 K has been obtained for the central filament. We report physical properties of ten compact sources, including six associated protostars, by fitting SEDs to multi-wavelength data. All of these compact sources are still quite cold (typical temperature below ~ 16 K) and are above the critical Bonner-Ebert mass. They have associated low-power young stellar objects. Further evidence for starless clumps has also been found in the IC 5146 region.
Online community detection in social sensing (2013)

The proliferation of location and GPS data streams which are collected in a wide variety of participatory sensing applications has created numerous possibilities for analysis of the underlying patterns of activity. Typically, the spatio-temporal patterns arising from such activity can be analyzed in order to determine the latent community structure in the underlying data. In this paper, we will examine the problem of online community detection from the location data collected from such social sensing applications in real time. Such data brings numerous challenges associated with it, in that they can be of a relatively large scale, and can be extremely noisy from the perspective of both data representation and analysis. Furthermore, the community structure in the underlying data cannot be directly inferred from the shape of the underlying trajectories, since a considerable amount of variation may exist in terms of trajectories of individuals belonging to the same community. In this paper, we will design online algorithms for community detection in social sensing applications. Our algorithm uses a robust and efficiently updateable model with the use of Gibbs sampling, and we will show its effectiveness and efficiency for social sensing applications.
Characteristics of Microwave Receivers (2005)

In this chapter, some common terms representing the characteristics and performance of EW receivers will be discussed. These terms include sensitivity, dynamic range, probability of intercept (POI), and throughput rate. Although used on a daily basis, some of these terms are not clearly defined and others have too many definitions. This chapter will discuss the different definitions and try to clarify them. Among all the terms, emphasis will be placed on receiver sensitivity and dynamic range. Important concepts used to design receivers will also be included. In the discussion of receiver sensitivity, the effect of video bandwidth will be included. The sensitivity is a function of the ratio of radio-frequency (RF) bandwidth to video bandwidth. Curves will be provided to predict the receiver sensitivity. Most of the receiver measurements will be discussed in Chapter 12. However, the measurement of false alarm rates will be discussed in this chapter, because it is closely related to the sensitivity of the receiver. The equations used to calculate the sensitivity of a receiver are also used to calculate the false alarm rate. Examples will be presented to demonstrate utilization of the equations and curves.
Supplementary Fig. S1 from PHA-739358, a potent inhibitor of Aurora kinases with a selective target inhibition profile relevant to cancer (2023)

Supplementary Fig. S1 from PHA-739358, a potent inhibitor of Aurora kinases with a selective target inhibition profile relevant to cancer
FCPA System at 2.08 µm and 7 MHz in All-PM Design Delivering Pulses at 10 nJ and 390 fs Pulse Duration (2014)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text H. Hoogland, S. Wittek, W. Hänsel, and R. Holzwarth, "FCPA System at 2.08 µm and 7 MHz in All-PM Design Delivering Pulses at 10 nJ and 390 fs Pulse Duration," in CLEO: 2014, OSA Technical Digest (online) (Optica Publishing Group, 2014), paper SM1O.5. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
5G Radio Access Network Architecture: Design Guidelines and Key Considerations (2016)

While there is clarity on the wide range of applications that are to be supported by 5G cellular communications, and standardization of 5G has now started in 3GPP, there is no conclusion yet on the detailed design of the overall 5G RAN. This article provides a comprehensive overview of the 5G RAN design guidelines, key design considerations, and functional innovations as identified and developed by key players in the field.1 It depicts the air interface landscape that is envisioned for 5G, and elaborates on how this will likely be harmonized and integrated into an overall 5G RAN, in the form of concrete control and user plane design considerations and architectural enablers for network slicing, supporting independent business-driven logical networks on a common infrastructure. The article also explains key functional design considerations for the 5G RAN, highlighting the difference to legacy systems such as LTE-A and the implications of the overall RAN design.
Making a world of difference recruitment of undergraduate students at USU (2003)

This paper describes two creative methods that are used to recruit undergraduate students at Utah State University. The first is "Engineering State", a four-day hands-on immersement in a wide array of engineering disciplines, and the second is a slide show called "Making a World of Difference-Women in Engineering" that was created by a woman engineering student to provide an uplifting, upbeat look at the difference a woman can make in the world if she becomes an engineer, and to encourage young women to take a second look at the opportunities engineering presents for them. The Engineering State program has been inplace since 1992 and has had clear, measurable benefits in the recruitment of students to USU engineering programs. One of the goals of Engineering State is to attract women and minorities to consider an engineering career. The engineering students who have seen the preliminary portions of the new slide show have excited comments, smiles on their faces, and a renewed positive outlook. It is hoped that this exposure will provide much-needed role models, success stories, and a new look at engineering as the people-oriented profession that it can be. This slide show is available free to interested faculty, and is downloadable in Power Point format from the Web.
Mannose 6‐phosphonate labelling: A key for processing the therapeutic enzyme in Pompe disease (2019)

In the search of a better enzyme therapy in Pompe disease, the conjugation of mannose 6-phosphonates to the recombinant enzyme appeared as an enhancer of its efficacy. Here, we demonstrated that the increased efficacy of the conjugated enzyme is partly due to a higher intracellular maturation because of its insensitiveness to acid phosphatases during the routing to lysosomes.
Review: Intensive insulin pump therapy slightly improves glycemic control in type 1 diabetes (2002)

Source Citation Pickup J, Mattock M, Kerry S. Glycaemic control with continuous subcutaneous insulin infusion compared with intensive insulin injections in patients with type 1 diabetes: meta-analysis of randomised controlled trials. BMJ. 2002 Mar 23;324:705-8. 11909787
On the Physical Interpretation of the Saleh–Valenzuela Model and the Definition of Its Power Delay Profiles (2014)

The physical motivation and interpretation of the stochastic propagation channel model of Saleh and Valenzuela are discussed in detail. This motivation mainly relies on assumptions on the stochastic properties of the positions of transmitter, receiver and scatterers in the propagation environment, and on the frequency range that is covered by the model. Some of these assumptions break down when the application of the model is extended from wideband to ultra-wideband propagation channels. Another important difference between these application contexts is the spatial scale over which the stochastic properties of the channel fluctuate when the transmitter or receiver is moved. This is further illustrated by analyzing the average power delay profile and some other channel properties for different levels of ensemble averaging, and discussing the relation between the ensemble averaging levels and the spatial variation scales. The notion of the averaging levels is essential for correct interpretation of the model, and hence for appropriate channel characterization and system design.
S0502-6-1 Stability Problems of Sheet Jets/Film Flows of Liquid Lithium for the Target and Coolant of BNCT using Accelerators (2010)

We tackle the stability problems on the flow upstream both sheet jets / film flows of liquid lithium planned for the target and coolant of BNCT (Boron Neutron Capture Therapy) using accelerators which makes tumors curable with cell-level selections. The object of our research is the thin and high-speed sheet jets / film flows of liquid lithium in a vacuum because of the ambiance using accelerators, and it serves both as a target of accelerators and as a coolant for the target itself. In this paper, we discuss the framework and stabilizing strategies of the above severe stability problems on the flows upper the outlet of the slit-nozzle.
Titelbild: Das Wolframatogermanat [Ce20Ge10W100O376(OH)4(H2O)30]56−: ein Polyoxometallat mit 20 Cer(III)‐Atomen (Angew. Chem. 32/2007) (2007)

Das gigantische Polyoxometallat [Ce20Ge10W100O376(OH)4(H2O)30]56− (1) wurde in einer Eintopfsynthese aus CeIII-Ionen und der trilakunaren Vorstufe [α-GeW9O34]10− in Wasser erhalten, wie U. Kortz et al. in der Zuschrift auf S. 6305 ff. berichten. Das Titelbild zeigt die mögliche Entstehung über eine stufenweise Selbstorganisation, beginnend mit der Bildung von Ce2GeW10-Keggin-Einheiten, der Anordnung jeweils fünf solcher Einheiten zu chiralen, enantiomeren (Ce2GeW10)5-Spezies und der Dimerisierung der R- und S-Formen zu 1.
The variability residual stresses of thick superconductor films during orthorhombic to tetragonal transformation (1992)

YBa{sub 2}Cu{sub 3}O{sub x} thick films have been deposited by spray pyrolysis of a sol-gel on 10 cm diameter polycrystalline MgO wafers. The film thickness was built up in layers of approximately 1 {mu}m thick. The in-plane residual stresses were measured by an optical interferometry (shadow moire) method as a function of film structure. In-plane residual stress maps over the area of the wafer have been obtained. The average stress of the 5 {mu}m orthorhombic phase was 0.84 GPa. As the film transforms from the orthorhombic to the tetragonal structure, the tensile stresses decreased by 0.5 GPa.
Tuning Fructosyl Peptidyl Oxidase into Dehydrogenase and Its Application for the Construction of an Enzyme Electrode (2011)

Fructosyl valyl-histidine, which is released from protease digestion of the major diabetes indicator HbA1c, is recognized as a target molecule for HbA1c sensors. The flavoenzyme fructosyl amino acid oxidase (FAOD) is an enzyme catalyzing the oxidative deglycation of fructosyl amino acids, with those also possessing high activity towards fructosyl dipeptides being referred to as fructosyl peptidyl oxidases (FPOXs). The high oxygen reactivity of FAODs and FPOXs limits their potential utility in amperometric enzyme sensors employing artificial electron mediators. We successfully modified the proton relay system of Pichia N1-1 FAOD, significantly decreasing its catalytic ability to employ oxygen as the electron acceptor, while having little effect on the dye-mediated dehydrogenase activity employing artificial electron acceptors instead of oxygen. We expect that similar engineering of a recently discovered FPOX will produce an enzyme that is ideally suited for HbA1c sensing.
Inside Cover: Identification of Anchor Points for Chemical Modification of a Small Cysteine‐Rich Protein by Using a Cysteine Scan (ChemBioChem 16/2011) (2011)

The inside cover picture shows the cysteine scanning mutagenesis of insulin in yeast resulting in expression of post-translationally modified insulin analogues. On p. 2448 ff, F. Hubálek et al. show how selective reduction and subsequent alkylation of the introduced cysteine residues allow for chemoselective modification of insulin, as illustrated by a PEGylated insulin variant.
A New and Efficient Access to Oxazoline-5-carboxylates and Amino Acid Derivatives with Cyclopropyl Groups1 (2000)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTA New and Efficient Access to Oxazoline-5-carboxylates and Amino Acid Derivatives with Cyclopropyl Groups1Marcus W. Nötzel, Markus Tamm, Thomas Labahn, Mathias Noltemeyer, Mazen Es-Sayed, and Armin de MeijereView Author Information Institute für Organische und Anorganische Chemie der Georg-August-Universität Göttingen, Tammannstrasse 2−4, D-37077 Göttingen, Germany and Bayer AG, Landwirtschaftszentrum, Alfred-Nobel-Strasse 50, Geb. 6510, D-40789 Monheim, Germany Cite this: J. Org. Chem. 2000, 65, 12, 3850–3852Publication Date (Web):May 23, 2000Publication History Received29 January 1999Published online23 May 2000Published inissue 1 June 2000https://doi.org/10.1021/jo990170yCopyright © 2000 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views263Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (52 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Alkyls,Amides,Monomers,Peptides and proteins,Reaction products Get e-Alerts
Genetic markers of male infertility: Y chromosome microdeletions and cystic fibrosis transmembrane conductance gene mutations. (2001)

Today, approximately 15% of couples have reduced fertility. In most cases the reason is male infertility, usually of genetic origin. Thus, in the context of research in genes involved in reproduction and sex determination, genetic defects in gametogenesis are being extensively studied. The most frequent pathogenic causes of male infertility are Y chromosomal microdeletions and obstructive azoospermia due to congenital absence of the vas deferens (CAVD) in the presence of mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. We have investigated the most common CFTR gene alterations in Croatian men with CAVD, using Roche research prototype assays. Results revealed that the 5T variant was present in 27% of the subjects. The F508 deletion was found in 21% of the subjects. It was the most frequent mutation, although its incidence was much lower than among patients with cystic fibrosis. The prevalence of microdeletions in the azoospermia factor region (AZF) of the Y chromosome in Croatia was 4.5%. This is the first report of Y microdeletions in the Croatian population. Genetic counseling of all couples with the diagnosis of male infertility is recommended before intrauterine insemination, in vitro fertilization, and intracytoplasmic sperm injection, and should also include AZF and CFTR genotyping. Couples requesting assisted reproductive treatment should be offered molecular analysis of the CFTR gene, if male infertility due to obstructive azoospermia is the underlying cause. Also, men with severe oligozoospermia or non-obstructive azoospermia seeking assisted reproductive treatment should be screened for deletions in the Y chromosome.
Characterization of Transient Effects in the S-Parameters of GaAs MESFETs by Means of Pulsed Measurements (1994)

This paper presents a characterization of the main transient phenomena affecting the S-parameters of GaAs MESFETs, carried out by means of an innovative Six Port Network Analyzer operated in burst mode. The results, interpreted using established models of the small signal MESFET behavior, indicate that the transient effects observed in the S-parameters must be attributed to changes in the device transconductance and output conductance, while minor anomalies affect the input, output and feedback capacitance.