gebhart/patrepeval huggingface dataset:
Expression of two aldolase A mRNA species in different human and rat tissues (1986)

Conference Article| August 01 1986 Expression of two aldolase A mRNA species in different human and rat tissues F. SCHWEIGHOFFER; F. SCHWEIGHOFFER 1Inserm U 129, 24 rue du Fg St Jacques, 75674 Paris Cedex 14, France Search for other works by this author on: This Site PubMed Google Scholar F. MENNECIER; F. MENNECIER 1Inserm U 129, 24 rue du Fg St Jacques, 75674 Paris Cedex 14, France Search for other works by this author on: This Site PubMed Google Scholar P. MAIRE; P. MAIRE 1Inserm U 129, 24 rue du Fg St Jacques, 75674 Paris Cedex 14, France Search for other works by this author on: This Site PubMed Google Scholar L. BACHNER; L. BACHNER 1Inserm U 129, 24 rue du Fg St Jacques, 75674 Paris Cedex 14, France Search for other works by this author on: This Site PubMed Google Scholar A. KAHN A. KAHN 1Inserm U 129, 24 rue du Fg St Jacques, 75674 Paris Cedex 14, France Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1986) 14 (4): 718–719. https://doi.org/10.1042/bst0140718 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation F. SCHWEIGHOFFER, F. MENNECIER, P. MAIRE, L. BACHNER, A. KAHN; Expression of two aldolase A mRNA species in different human and rat tissues. Biochem Soc Trans 1 August 1986; 14 (4): 718–719. doi: https://doi.org/10.1042/bst0140718 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1986 Biochemical Society1986 Article PDF first page preview Close Modal You do not currently have access to this content.
P-Type Doping Effects on Band-Gap Energy for Ga0.5In0.5P Grown by Metalorganic Vapor Phase Epitaxy (1988)

Photoluminescence properties of Mg- or Zn-doped Ga 0.5 In 0.5 P grown by metalorganic vapor phase epitaxy were studied as a function of hole concentration ( p ). The band-gap energy ( E g ) value for Mg- or Zn-doped Ga 0.5 In 0.5 P, grown under a condition in which undoped Ga 0.5 In 0.5 P shows an anomalously low E g , showed a steep increase for p ∼&gt;1×10 18 cm -3 . This anomalous behavior was attributed to the Mg or Zn diffusion-enhanced randomization of the previously observed naturally formed monolayer {1/2, 1/2, 1/2} superlattices on the column III sublattice.
Comment on: An update on cefepime and its future role in combination with novel β-lactamase inhibitors for MDR Enterobacterales and Pseudomonas aeruginosa (2021)

We read with interest the publication by Isler et al.,1 reviewing four cefepime-based β-lactam/β-lactamase inhibitor combinations, i.e. cefepime/zidebactam, cefepime/taniborbactam, cefepime/enmetazobactam and cefepime/tazobactam. We commend the authors for attempting to derive the therapeutic range of these agents from their microbiology and pharmacodynamic (PD) profiles. While the authors have comprehensively reviewed publications on these combinations, their conclusion with respect to cefepime/zidebactam’s animal PD profile is misplaced. The authors conclude that the clinical efficacy of cefepime/zidebactam is doubtful for clinical isolates with high MICs, especially those that are greater than the cefepime susceptibility breakpoint (i.e. 8 mg/L), as the backbone β-lactam is the main determinant of the clinical efficacy of β-lactam/β-lactamase inhibitor combinations. We respectfully disagree with this assertion, as cefepime/zidebactam is not a classical β-lactam/β-lactamase inhibitor combination, rather its unconventional PD profile is derived from zidebactam’s ‘β-lactam enhancer’ action in addition to its inhibitory activity against Ambler class A and...
ChemInform Abstract: Expedient Synthesis of Biologically Important Sulfonylmethyl Pyrimidines. (2014)

Abstract Two novel strategies for the synthesis of sulfonylmethyl pyrimidines are presented.
Structural Features of the CytochromecMolten Globule Revealed by Fluorescence Energy Transfer Kinetics (2002)

Nonnative states of proteins are involved in a variety of cellular processes, including translocation of proteins across membranes and formation of amyloid fibrils. Probes that report on the structural heterogeneity of a polypeptide ensemble could resolve ambiguities in the classification of these states. Employing fluorescence energy transfer kinetics, we have shown that added anions shift the equilibrium between the compact and extended polypeptide structures that are present during refolding of Saccaromyces cerevisiae iso-1 cytochrome c. Specifically, at high salt concentrations (>/=700 mM), all of the polypeptides are compact with a mean C-terminal fluorophore-heme separation quite close to that in the native protein (25 A).
Hydroboration of Arynes with N‐Heterocyclic Carbene Boranes (2014)

Abstract Arynes were generated in situ from ortho ‐silyl aryl triflates and fluoride ions in the presence of stable N‐heterocyclic carbene boranes (NHCBH 3 ). Spontaneous hydroboration ensued to provide stable B‐aryl‐substituted NHC‐boranes (NHCBH 2 Ar). The reaction shows good scope in terms of both the NHC‐borane and aryne components and provides direct access to mono‐ and disubstituted NHC‐boranes. The formation of unusual ortho regioisomers in the hydroboration of arynes with an electron‐withdrawing group supports a hydroboration process with hydride‐transfer character.
Waveguide biosensor with integrated detector array for tuberculosis testing (2011)

A label-free immunoassay using a local evanescent array coupled (LEAC) biosensor is reported. Complementary metal oxide semiconductor chips with integrated photoconductor arrays are used to detect an antibody to a M. tuberculosis protein antigen, HspX. The metrology limits of the LEAC sensor using dc and ac measurement systems correspond to average film thicknesses of 28 and 14 pm, respectively. Limits of detection are 87 and 108 pm, respectively, for mouse immunoglobulin G antibody patterning and antigen detection.
Fates of imine intermediates in radical cyclizations of N-sulfonylindoles and ene-sulfonamides (2015)

Two new fates of imine intermediates formed on radical cyclizations of ene-sulfonamides have been identified, reduction and hydration/fragmentation. Tin hydride-mediated cyclizations of 2-halo-N-(3-methyl-N-sulfonylindole)anilines provide spiro[indoline-3,3'-indolones] or spiro-3,3'-biindolines (derived from imine reduction), depending on the indole C2 substituent. Cyclizations of 2-haloanilide derivatives of 3-carboxy-N-sulfonyl-2,3-dihydropyrroles also presumably form spiro-imines as primary products. However, the lactam carbonyl group facilitates the ring-opening of these cyclic imines by a new pathway of hydration and retro-Claisen-type reaction, providing rearranged 2-(2'-formamidoethyl)oxindoles.
Gold nanoparticles cellular toxicity and recovery: Effect of size, concentration and exposure time (2010)

Gold nanoparticles (AuNPs) are used in many applications; however, their interactions with cells and potential health risk(s) are not fully known. In this manuscript, we describe the interactions of AuNPs with human dermal fibroblasts and show that they can penetrate the plasma membrane and accumulate in large vacuoles. We also demonstrate that the uptake of the AuNPs is a function of time, their size and concentration. Specifically, we demonstrate that 45 nm AuNPs penetrate cells via clathrin-mediated endocytosis, while the smaller 13 nm enter mostly via phagocytosis. Furthermore, we provide evidence of cytoskeleton filament disruption as a result of AuNPs exposure and reconstitution during recovery (following AuNP removal), despite no changes in actin or beta-tubulin protein levels. In contrast, the expression of the extracellular matrix (ECM) proteins, collagen and fibronectin, was diminished in the cells exposed to AuNPs. We also examined the proliferation rates of cells exposed to AuNPs and show that its diminution is a function of apoptosis and speculate that apoptosis results from the number of vacuoles present in the cells, which is probably the main factor that disrupts the cytoskeleton causing cell area contraction and decreases in motility. Lastly, we also present data that indicates that AuNPs' damage to cells is not permanent and that the cells can completely recover as a function of AuNPs' size, concentration and exposure time. Taken together, our data suggest that AuNPs exert detrimental effects on cell function that could reverse following AuNPs removal.
Advanced Data Storage Materials and Characterization Techniques: Volume 803 2003 MRS Proceedings (2014)

This book unites two symposia from the 2003 MRS Fall Meeting in Boston to address data storage. As the size of material objects approaches nanometer dimensions, the material's structural and electronic properties change. The investigation of factors such as quantum size effects and the impact on next-generation recording media will become even more crucial in the near future, when recording densities approach Terabit/square inch. Therefore, the development of novel instrumentation to explore physical properties at these length scales are becoming more important. Results published here from Symposium GG, Advanced Characterization Techniques for Data Storage Materials, feature characterization techniques including imaging, manipulation and chemical imaging of magnetic, phase change and oxide materials. Symposium HH, Phase Change and Nonmagnetic Materials for Data Storage, gathers researchers working on materials issues related to electronic and optical phase change storage media. From a materials perspective, similar issues are researched in both types of storage technologies. The results published here focus on both applied and fundamental aspects of storage properties.
Autoreactive T cells with atypical MHC restriction from MRL-lpr/lpr mice: forbidden clones revisited. (1988)

MRL-lpr/lpr mice spontaneously develop a lethal form of systemic lupus erythematosus associated with massive lymphadenopathy, polyclonal B-cell activity, autoantibody production and antibody-dependent tissue injury. The sequence of events leading to B-cell proliferation and pathogenic autoantibody production are not clearly defined--abnormalities of both B and T cells have been observed. Isolation of individual T-cell clones would facilitate analysis of the cellular events involving both B and T cells that lead to autoantibody production. For this purpose, an autoreactive T-cell line (ARTC-1) was derived from the splenocytes of an unimmunized MRL-lpr/lpr mouse and maintained in culture by stimulation with syngeneic antigen presenting cells, without exogenous antigens. By T-cell receptor analysis it was demonstrated that ARTC-1 cells developed as a clone even through no attempt was made to clone them in vitro: Southern blot analysis of ARTC-1 revealed a single rearrangement of the TcR beta chain locus with the other TcR beta chain gene remaining in the germline configuration. Northern blot analysis confirmed these findings and demonstrated that ARTC-1 utilized C beta 1 J beta 1.3 exclusively. ARTC-1 had atypical MHC requirements for activation: antigen-presenting cells bearing both I-Ak and I-Ek major histocompatibility complex class II antigens were required for maximal proliferation of the ARTC-l clone. Activated ARTC-l secreted soluble factors that induced B-cell proliferation, immunoglobulin secretion, and anti-DNA antibody production. Unregulated cells of the AR-TC1 type could, therefore, lead to polyclonal B-cell activation and autoantibody production in vivo in the absence of exogenous antigenic stimulation.
Electromagnetic transient simulation of large-scale electrical power networks using graphics processing units (2012)

In this paper electromagnetic transient (EMT) simulation of large scale power systems using graphics processing unit (GPU) based computing is demonstrated. As the size of power system networks increases, the simulation time using conventional central processing units (CPUs) based simulation increases drastically. This paper proposes a hybrid CPU-GPU environment for fast large scale power systems simulation. In this scheme the GPU is mainly deployed to perform the computationally intensive part of the simulation in parallel on its built-in multiple processing cores, and the CPU is assigned for other sequential jobs like flow control of the simulation and storing output data, etc. The GPU-based approach is used to simulate a network with 900 Buses, and it is shown that the CPU-GPU based implementation is 70 times faster than the conventional CPU-based implementations.
ANTIBODIES AGAINST HAEMOPHILUS INFLUENZAE TYPE b CAPSULAR POLYSACCHARIDE AND TETANUS TOXOID BEFORE AND AFTER A BOOSTER DOSE OF THE CARRIER PROTEIN NINE YEARS AFTER PRIMARY VACCINATION WITH A PROTEIN CONJUGATE VACCINE (2005)

IgG antibodies against Haemophilus influenzae type b (Hib) capsular polysaccharide (CPS) and tetanus toxoid (TT) were measured for 53 children, 10 years of age, before and 1 month after a booster dose of diphtheria-tetanus vaccine (DT). All children had been vaccinated at 3, 5 and 12 months of age with DT and a Hib-TT conjugate. Geometric mean concentrations of Hib CPS serum IgG antibody were 4.16 and 4.30 microg/mL before and after the DT booster, respectively. The geometric mean concentration of TT IgG antibody increased from 0.09 IU/mL to 4.58 IU/mL (P < 0.001). Hib CPS IgG levels remained well above protective titers for 9 years after 3 doses of Hib-TT appropriately spaced in infancy. A booster dose of TT did not affect Hib CPS antibody concentrations but induced a pronounced IgG response against TT.
Phosphorylation and Processing of the Quorum-Sensing Molecule Autoinducer-2 in Enteric Bacteria (2007)

Quorum sensing is a process of chemical communication that bacteria use to assess cell population density and synchronize behavior on a community-wide scale. Communication is mediated by signal molecules called autoinducers. The LuxS autoinducer synthase produces 4,5-dihydroxy-2,3-pentanedione (DPD), the precursor to a set of interconverting molecules that are generically called autoinducer-2 (AI-2). In enteric bacteria, AI-2 production induces the assembly of a transport apparatus (called the LuxS regulated (Lsr) transporter) that internalizes endogenously produced AI-2 as well as AI-2 produced by other bacterial species. AI-2 internalization is proposed to be a mechanism enteric bacteria employ to interfere with the signaling capabilities of neighboring species of bacteria. We have previously shown that Salmonella enterica serovar Typhimurium binds a specific cyclic derivative of DPD. Here we show that following internalization, the kinase LsrK phosphorylates carbon-5 of the open form of DPD. Phosphorylated DPD (P-DPD) binds specifically to the repressor of the lsr operon, LsrR, consistent with P-DPD being the inducer of the lsr operon. Subsequently, LsrG catalyzes the cleavage of P-DPD producing 2-phosphoglycolic acid. This series of chemical events is proposed to enable enteric bacteria to respond to the presence of competitor bacteria by sequestering and destroying AI-2, thereby eliminating the competitors' intercellular communication capabilities.
All-Wet, Metal-Compatible High-Dose-Implanted Photoresist Strip (2012)

An all-wet process based on a novel chemistry has been developed to enable the removal of high-dose implanted photoresist in the presence of exposed metal layers and other materials typical of advanced gate stacks.
On acceptance criterion for efficient successive errors-and-erasures decoding of Reed-Solomon and BCH codes (1997)

We describe an efficient algorithm for successive errors-and-erasures decoding of BCH codes. The decoding algorithm consists of finding all necessary error locator polynomials and errata evaluator polynomials, choosing the most appropriate error locator polynomial and errata evaluator polynomial, using these two polynomials to compute a candidate codeword for the decoder output, and testing the candidate for optimality via an originally developed acceptance criterion. Even in the most stringent case possible, the acceptance criterion is only a little more stringent than Forney's (1966) criterion for generalised minimum distance (GMD) decoding. We present simulation results on the error performance of our decoding algorithm for binary antipodal signals over an AWGN channel and a Rayleigh fading channel. The number of calculations of elements in a finite field that are required by our algorithm is only slightly greater than that required by hard-decision decoding, while the error performance is almost as good as that achieved with GMD decoding. The presented algorithm is also applicable to efficient decoding of product RS codes.
An Energy Framework for the Network Simulator 3 (ns-3) (2011)

The Network Simulator-3 (ns-3) is rapidly developing into a flexible and easy-to-use tool suitable for wireless network simulation. Since energy consumption is a key issue for wireless devices, wireless network researchers often need to investigate the energy consumption at a battery powered node or
ChemInform Abstract: Synthesis and Structure of a Novel Lewis Acid‐Base Adduct, (H3C)3SiN3. times.GaCl3, en Route to Cl2GaN3 and Its Derivatives: Inorganic Precursors to Heteroepitaxial GaN. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Complexation of samarium ion with poly(acrylic acid) grafted onto polyethylene by radiation‐induced method (1984)

Abstract Acrylic acid was graft‐polymerized onto polyethylene powder by preirradiation method. The grafted powder (PE‐ g ‐AA) rapidaly adsorbed Sm 3− ion in high efficiency. The poly(acrylic acid) grafted to the surface region of PE acted as an effective chelating site for the relatively large Sm ion. The complex formation constant of Sm ion with PE‐ g ‐AA was much larger than those of Sm ion with poly(acrylic acid) and propionic acid and of Cu 2+ ion with PE‐ g ‐AA.
New challenges in optical materials development (1993)

The recent emergence of high performance semiconductor laser diodes and diode arrays emitting at wavelengths between 630 and 2300 nm has enabled the demonstration of several novel diode-pumped solid state laser materials. Narrowly, laser diode arrays may be viewed as simple replacements for conventional flash or arc lamp pumps in solid state lasers. The examples discussed in this paper illustrate that laser diode array pumps are considerably more versatile, enabling novel high performance lasers that are technically not feasible using conventional flashlamps. Additionally, several relatively new nonlinear optical materials, possessing high nonlinearities and excellent phase-matching properties, offer good prospects for the development of efficient, compact, wavelength-diverse all-solid-state laser sources.
A single-ended CMOS chopper amplifier for 1/f noise reduction of n-channel MOS transistors (2012)

This paper describes a single-ended CMOS chopper amplifier for 1/f noise reduction of n-channel MOS transistors and its application to a low-noise high-gain switched-capacitor (SC) amplifier for sensor interface circuits. Since the chopping is used inside of the operational transconductance amplifier (OTA), this amplifier can be used for high output impedance sensors. To investigate the effect of the proposed chopping technique, a test chip was fabricated using 0.25µm mixed-signal CMOS process. The total input-referred noise is greatly reduced by using a high chopping frequency of 256kHz to 20µVrms from 295µVrms without chopping.
Stomach cancer risk following radiotherapy for testicular cancer. (2013)

4536 Background: Testicular cancer (TC) is a highly curable malignancy occurring most commonly among men aged 15-34 years. Survivors are at increased risk for adverse late effects of therapy. Previous studies have reported more than 4-fold risks of stomach cancer after TC, although the potential role of radiotherapy and chemotherapy for TC in these associations is unclear. Methods: We evaluated stomach cancer risk in an international cohort of 23,982 men diagnosed with TC during 1959-1987. Using detailed radiotherapy records, doses to the stomach tumor location were estimated for 92 stomach cancer patients and 180 individually matched controls. Chemotherapy drugs and doses also were recorded. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using conditional logistic regression. Results: Fifty-seven percent of patients with stomach cancer were diagnosed with TC before age 40 years, 65% had seminoma, 95% had stage I or II disease, and 37% were diagnosed with stomach cancer ≥20 years after TC diagnosis. Patients who received radiotherapy [87 (95%) cases, 151 (84%) controls] had a 5.9-fold (95%CI 1.6-21.3) increased risk of stomach cancer compared with patients who did not receive radiotherapy. Risk increased with increasing radiation dose to the stomach (P-trend&lt;0.001), with ORs of 3.6 (95%CI 1.3-10.6), 4.4 (1.2-16.4) and 13.3 (2.5-70.0) after 20-39.9 Gy, 40-49.9 Gy, and ≥50 Gy radiation to the stomach, respectively, compared with &lt;10 Gy. Radiation-related stomach cancer risk did not vary by calendar year of treatment, age at exposure, or TC histology. The OR for having received any chemotherapy was 1.3 (14 cases, 23 controls, 95% CI 0.6-2.8). Stomach cancer risk was not significantly elevated among patients given cisplatin-based chemotherapy (7 cases, 10 controls, OR=1.7, 95% CI 0.6-5.1). Conclusions: Patients administered radiotherapy for TC in the past are at increased risk of developing stomach cancer, particularly those who received ≥20 Gy to the stomach. The study results warrant consideration in radiation risk assessment and long-term follow-up. Future studies should further investigate a possible role for chemotherapy in stomach cancer risk.
Mode Division Multiplexed Transmission with Waveguide Mode Multi/Demultiplexer (2013)

We demonstrated mode multi/demultiplexing with an asymmetric parallel waveguide for mode division multiplexed transmission, which we designed and fabricated to multiplex the LP01 and LP11 modes. Our fabricated mode multi/demultiplexer realized a low insertion loss of &lt 0.8dB for the LP01 and LP11 modes. We achieved a 2 mode × 4 wavelength × 10 Gbps MDM-WDM transmission in the C-band over a 9 km-long two-mode ﬁ ber using a waveguide mode multi/demultiplexer with a low insertion loss and highly efﬁ cient mode conversion.
What Is The Optimal Concentration Of Ropivacaine For Continuous Epidural Infusion For Labor Pain? (1999)

ANESTHESIOLOGY is the highest-impact, peer-reviewed medical journal that publishes trusted evidence that transforms the practice of perioperative, critical care, and pain medicine along with clinical reviews, editorials, podcasts, infographics, and videos.