gebhart/patrepeval huggingface dataset:
5G-ICN: Delivering ICN Services over 5G Using Network Slicing (2017)

The challenging requirements of 5G, from both the applications and architecture perspectives, motivate the need to explore the feasibility of delivering services over new network architectures. As 5G proposes application-centric network slicing, which enables the use of new data planes realizable over a programmable compute, storage, and transport infrastructure, we consider information- centric networking as a candidate network architecture to realize 5G objectives. This can coexist with end-to-end IP services that are offered today. To this effect, we first propose a 5G-ICN architecture and compare its benefits (i.e., innovative services offered by leveraging ICN features) to current 3GPP-based mobile architectures. We then introduce a general application-driven framework that emphasizes the flexibility afforded by network functions virtualization and software defined networking over which 5G-ICN can be realized. We specifically focus on the issue of how mobility as a service (MaaS) can be realized as a 5G-ICN slice, and give an in-depth overview on resource provisioning and inter-dependencies and coordination among functional 5G-ICN slices to meet the MaaS objectives. The article tries to show the flexibility of delivering services over ICN where virtualization of control and data plane can be used by applications to meet complex service logic execution while creating value to its end users.
Colon cancer-derived oncogenic EGFR G724S mutant identified by whole genome sequence analysis is dependent on asymmetric dimerization and sensitive to cetuximab (2014)

The colon-cancer derived G719S and G724S mutants are oncogenic and sensitive in vitro to cetuximab. These data suggest that patients with these mutations may benefit from the use of anti-EGFR antibodies as part of the first-line therapy.
Tumor Suppressor Cylindromatosis (CYLD) Controls HIV Transcription in an NF-κB-Dependent Manner (2014)

HIV transcription is regulated by a number of host cell factors. Here we report that silencing of the lysine 63 deubiquitinase CYLD increases HIV transcription in an NF-κB-dependent manner. We show that CYLD is expressed in HIV target cells and that its silencing increases HIV infection in transformed T cell lines as well as primary CD4(+) T cells. Similarly, reactivation of latent provirus was facilitated in the absence of CYLD. These data suggest that CYLD, which is highly expressed in CD4(+) T cells, can control HIV transcription in productive infection as well as during reactivation from latency.
Retailing (RLE Retailing and Distribution) (2012)

This textbook provides an up-to-date, comprehensive and fully integrated treatment of retailing as a) and industry, b) a force shaping social attitudes and contemporary culture, and c) a force for change in modern townscapes. Unlike other texts which focus on specific topics, this book provides a treatment of retailing which will appeal to geographers, economists, planners and social scientists. First published 1991.
Lysosome Targeting Chimeras (LYTACs) for the Degradation of Secreted and Membrane Proteins (2019)

Targeted protein degradation is a powerful strategy to address the canonically undruggable proteome. However, current technologies are limited to targets with cytosolically-accessible and ligandable domains. Here, we designed and synthesized conjugates capable of binding both a cell surface lysosome targeting receptor and the extracellular domain of a target protein. These lysosome targeting chimeras (LYTACs) consist of an antibody fused to agonist glycopeptide ligands for the cation-independent mannose-6-phosphate receptor (CI-M6PR). LYTACs enabled a CRISPRi knockdown screen revealing the biochemical pathway for CI-M6PR-mediated cargo internalization. We demonstrated that LYTACs mediate efficient degradation of Apolipoprotein-E4, epidermal growth factor receptor (EGFR), CD71, and programmed death-ligand 1 (PD-L1). LYTACs represent a modular strategy for directing secreted and membrane proteins for degradation in the context of both basic research and therapy.
Chromatographic resolution of the antipodes of a helical complex of nickel(II) (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChromatographic resolution of the antipodes of a helical complex of nickel(II)Larry Thomas. Taylor and Daryle H. BuschCite this: J. Am. Chem. Soc. 1967, 89, 21, 5372–5376Publication Date (Print):October 1, 1967Publication History Published online1 May 2002Published inissue 1 October 1967https://pubs.acs.org/doi/10.1021/ja00997a012https://doi.org/10.1021/ja00997a012research-articleACS PublicationsRequest reuse permissionsArticle Views122Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Regulatory Role of Dendritic Cells in Postinfarction Healing and Left Ventricular Remodeling (2012)

These results suggest that the DC is a potent immunoprotective regulator during the postinfarction healing process via its control of monocyte/macrophage homeostasis.
ChemInform Abstract: A Simple Construction of 2‐Phenylimino‐1,3‐thiazolidin‐4‐ones. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Antibodies to meningococcal class 1 outer membrane proteins in South African complement-deficient and complement-sufficient subjects (1992)

Inhibition assays were used to investigate human serum antibodies to the meningococcal class 1 outer membrane proteins. We adapted the whole-cell enzyme-linked immunosorbent assay technique to determine the ability of sera to inhibit the binding of murine subtyping monoclonal antibodies. Serum samples from 33 South African subjects with a deficiency in the sixth component of complement as well as serum samples from various groups of complement-sufficient subjects were investigated. Subjects were subdivided according to whether they were (i) convalescent from Neisseria meningitidis infections, (ii) nonconvalescent, or (iii) controls. Preliminary subtyping investigations had shown that P1.2 was present on 36% of meningococcal clinical isolates from Cape Province, South Africa. Assays with the anti-P1.2 antibodies showed the presence of high antibody levels in many deficient sera and moderately elevated levels in some sera from the complement-sufficient convalescent patients. P1.2, P1.4, P1.15, and P1.16 are epitopes situated on loop 4 of the class 1 outer membrane proteins, whereas P1.7 is on loop 1. Inhibition assays showed that human sera that inhibited binding by P1.2 monoclonal antibodies tended to inhibit the other monoclonal antibodies directed to loop 4 epitopes. This suggests that the epitopes recognized by the human antibodies are not exactly the same as the epitopes recognized by the murine monoclonal antibodies and raises the possibility of the importance of other epitopes.
RSA Can Measure ACL Graft Stretching and Migration (2006)

Diagnostic Level II. See Guidelines for Authors for a complete description of levels of evidence.
Supplementary Data from Reorganization of the 3D Genome Pinpoints Noncoding Drivers of Primary Prostate Tumors (2023)

&lt;p&gt;Supplementary Figures and descriptions for Supplementary Tables&lt;/p&gt;
Tumor burden, inflammation, and product attributes determine outcomes of axicabtagene ciloleucel in large B-cell lymphoma (2020)

ZUMA-1 demonstrated a high rate of durable response and a manageable safety profile with axicabtagene ciloleucel (axi-cel), an anti-CD19 chimeric antigen receptor (CAR) T-cell therapy, in patients with refractory large B-cell lymphoma. As previously reported, prespecified clinical covariates for secondary end point analysis were not clearly predictive of efficacy; these included Eastern Cooperative Oncology Group performance status (0 vs 1), age, disease subtype, disease stage, and International Prognostic Index score. We interrogated covariates included in the statistical analysis plan and an extensive panel of biomarkers according to an expanded translational biomarker plan. Univariable and multivariable analyses indicated that rapid CAR T-cell expansion commensurate with pretreatment tumor burden (influenced by product T-cell fitness), the number of CD8 and CCR7+CD45RA+ T cells infused, and host systemic inflammation, were the most significant determining factors for durable response. Key parameters differentially associated with clinical efficacy and toxicities, with both theoretical and practical implications for optimizing CAR T-cell therapy. This trial was registered at www.clinicaltrials.gov as #NCT02348216.
Preparation of a Stably Transfected Cell Line with an Expression Vector for the 1,25D 3 -MARRS Receptor (2008)

Commercially available bacterial and mammalian expression systems often don’t work with avian plasmids due to codon bias associated with bird proteins. My colleagues and I developed an expression system for chicken Membrane Associated Rapid Response to Steroid (MARRS) binding protein using a commercially available quail sarcoma cell line (QT-6) and a jointly prepared plasmid containing chicken MARRS (chMARRS). The QT-6 cells transfected with chMARRS showed similar morphology to parental cells and were able to bind 1a,25 (OH) 2 vitamin D 3 , the active form of vitamin D. Although there were differences in the growth curves between parent and transfected cells, transfection did not adversely affect cell growth. These cells make an excellent expression vector for chMARRS, and have provided protein for binding studies.
Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates (2020)

Abstract The induction of broad and potent immunity by vaccines is the key focus of research efforts aimed at protecting against HIV-1 infection. Soluble native-like HIV-1 envelope glycoproteins have shown promise as vaccine candidates as they can induce potent autologous neutralizing responses in rabbits and non-human primates. In this study, monoclonal antibodies were isolated and characterized from rhesus macaques immunized with the BG505 SOSIP.664 trimer to better understand vaccine-induced antibody responses. Our studies reveal a diverse landscape of antibodies recognizing immunodominant strain-specific epitopes and non-neutralizing neo-epitopes. Additionally, we isolated a subset of mAbs against an epitope cluster at the gp120-gp41 interface that recognize the highly conserved fusion peptide and the glycan at position 88 and have characteristics akin to several human-derived broadly neutralizing antibodies.
Application of New Fracturing Technique Improves Stimulation Success for Openhole Horizontal Completions (2004)

Proposal A relatively new technique for applying fractures (both proppant fracs and acid fracs)1–3 in horizontal openhole and uncemented liner completions is giving operators a more effective method for stimulation of underachieving wells. The process incorporates the known technologies of hydrajetting and fracturing in a novel way to achieve individual fracture placement at several selected locations along the lateral without the need for mechanical isolation methods, usually with only one service trip to the location. Depending on the number of fracturing stages desired, most job times vary from 6 to 12 hr if there are no hole-entry, tool, or logistic problems. Use of this new stimulation process continues to expand in the USA and Canada, and during the fourth quarter of 2002 and the first half of 2003, application of this process was successfully expanded beyond these original development areas to include offshore South America and a region of northern Asia. Before the end of 2003, numerous other locations around the globe are also planning to implement this stimulation technology on underperforming horizontal completions. Although this stimulation technique can also be used for cemented liners, its unique ability to control fracture placement in openhole and uncemented liner applications will be the focus of this paper. Only a brief review the basic technology is presented here, as numerous earlier publications provide more detail. New case histories will be presented wherein the application of this process has provided the operator with a distinct improvement in well completion economics.
Green Fluorescent Protein Retroviral Vector: Generation of High-Titer Producer Cells and Virus Supernatant (2003)

Genes-encoding marker proteins, which are easily assayable, are useful to monitor cell lineage, gene expression, or promoter activities. In gene-transfer technology such marker genes allow a direct and simple detection of successfully transduced cells. The detection of marker gene products such as β-galactosidase (β-gal), chloramphenicol acetyltransferase (CAT), alkaline phosphatase, or luciferase involves either cell fixation, which kills the cells or antibody-mediated detection, which is time consuming. Drug-resistance genes such as neomycin, puromycin, hygromycin, or zeocin allow a positive selection of transduced cells, but require days to weeks of growth in selective media. Moreover, these genes can change the growth characteristics of the transduced cells through terminal differentiation or can interfere with the expression of the gene of interest (1). Therefore, a marker gene system that provides timely, accurate, and nontoxic detection of successfully transduced living cells would be of great advantage. One interesting candidate gene that fulfills these requirements is the gene-encoding green fluorescent protein (GFP). It was originally isolated from the jellyfish Aquorea victoria. The GFP cDNA consists of 730 bp, which encode a 238 amino acid protein with a molecular weight of 27 kD (2). Wild-type GFP emits a vibrant green fluorescence upon exposure to blue light (450-490 nm). The signal is detectable by fluorescence microscopy and fluorescence-activated cell sorting (FACS) (3). Because the fluorescence of wild-type GFP after excitation is not strong enough for many applications, different variants of GFP have been developed. In one such variant, a point mutation was introduced at amino acid 65 (GFP-S65T) leading to a "red-shifted" excitation maximum with an approximately five-fold stronger fluorescent intensity (4). In a further variant, the "red-shifted" GFP was "humanized" by the introduction of numerous silent mutations that alter the codons to those more commonly used in human genes resulting in the improved translation of the gene (5-7). An additional point mutation at amino acid 64 in which phenylalanine was altered to leucine (F64L) further enhances gene expression (8). GFP has been expressed without cytotoxic effects in different organisms and is of special interest as a marker for monitoring cell lines and gene expression (3). The application of GFP in gene-transfer protocols allows the simple detection of transduced cells and offers the possibility for immediate enrichment of viable transduced cells by FACS (3,9,10). This is of great interest in gene transfer into poorly transducable cells, e.g., hematopoietic stem and progenitor cells.
Numerical analysis of nanowire surface recombination using a three-dimensional transient model (2018)

To characterize surface recombination of nanowires, time-resolved photoluminescence (TRPL) is commonly implemented to correlate measured lifetime with the nonradiative effect at surface. In this work, we develop a threedimensional transient model to perform a numerical analysis of surface recombination for InGaAs nanowires on GaAs substrates. By mimicking a complete TRPL measurement process, we computationally calculate optical generation and emission of InGaAs nanowires, and numerically probe the carrier dynamics inside nanowires. It is found that the TRPL spectra are determined by a complex convolution of surface recombination velocity and incident wavelengths. In addition, we show that due to the three-dimensional geometry of nanowire, using a typical analytical equation to extract surface recombination velocity might be no longer valid. We believe these results provide an alternative approach for the computational analysis of TRPL measurements and surface properties for three-dimensional nanostructured devices.
Early Opportunities for Commercialization of TV Whitespace in the U.S (2008)

We propose the use of IP-based broadband wireless protocols to address many of the applications needs in the Television White Space (TVWS) frequencies that will be available for secondary usage in the U.S. beginning in 2009. The work includes a discussion of TVWS physical and regulatory characteristic and a view of the TVWS usage models that may be applied in various market spaces, including the home, the enterprise, public safety and wireless mobile service providers. We show that a protocol based on IEEE 802.16e or a similar broadband wireless protocol could be adapted to meet many of the needs in this space.
Abstract P17. Ability to Cope with Chronic Pain Puts Migraine Surgery Patients in Perspective (2017)

Purpose: Migraine surgery candidates are chronic pain patients. However, chronic pain analysis tools are not typically applied to migraine surgery patients. This is the first migraine study to include the Pain Self Efficacy Questionnaire (PSEQ), which is used to determine patients’ pain coping abilities. It is an important predictor of pain intensity/disability in patients with musculoskeletal pain. Methods: Forty patients prospectively completed Migraine Headache Index, Migraine Disability Assessment Score (MIDAS) and PSEQ preoperatively, and 12 months postoperatively. Scores were evaluated using paired t-tests and Pearson correlation. PSEQ scores were compared to other chronic pain conditions. Results: All scores improved significantly from baseline. Mean preoperative migraine PSEQ score was 19 ± 11, the poorest pain coping score reported in the literature. Mean postoperative migraine PSEQ improvement was 105%(39 ± 22), which was the highest of those compared. Conclusion: MIDAS is suboptimal to describe disability in our patients due to a mean preoperative score of 102, as severe disability is defined as 21+. PSEQ successfully demonstrates extent of disability in this patient population and puts migraine surgery in perspective to other known pain treatments. It further evaluates functional outcome, rather than just improvement in symptoms. This significantly adds to our understanding of this patient population.
Data from Intratumoral Plasmid IL12 Expands CD8<sup>+</sup> T Cells and Induces a CXCR3 Gene Signature in Triple-negative Breast Tumors that Sensitizes Patients to Anti–PD-1 Therapy (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;Triple-negative breast cancer (TNBC) is an aggressive disease with limited therapeutic options. Antibodies targeting programmed cell death protein 1 (PD-1)/PD-1 ligand 1 (PD-L1) have entered the therapeutic landscape in TNBC, but only a minority of patients benefit. A way to reliably enhance immunogenicity, T-cell infiltration, and predict responsiveness is critically needed.&lt;/p&gt;Patients and Methods:&lt;p&gt;Using mouse models of TNBC, we evaluate immune activation and tumor targeting of intratumoral IL12 plasmid followed by electroporation (tavokinogene telseplasmid; Tavo). We further present a single-arm, prospective clinical trial of Tavo monotherapy in patients with treatment refractory, advanced TNBC (OMS-I140). Finally, we expand these findings using publicly available breast cancer and melanoma datasets.&lt;/p&gt;Results:&lt;p&gt;Single-cell RNA sequencing of murine tumors identified a CXCR3 gene signature (CXCR3-GS) following Tavo treatment associated with enhanced antigen presentation, T-cell infiltration and expansion, and PD-1/PD-L1 expression. Assessment of pretreatment and posttreatment tissue from patients confirms enrichment of this CXCR3-GS in tumors from patients that exhibited an enhancement of CD8&lt;sup&gt;+&lt;/sup&gt; T-cell infiltration following treatment. One patient, previously unresponsive to anti–PD-L1 therapy, but who exhibited an increased CXCR3-GS after Tavo treatment, went on to receive additional anti–PD-1 therapy as their immediate next treatment after OMS-I140, and demonstrated a significant clinical response.&lt;/p&gt;Conclusions:&lt;p&gt;These data show a safe, effective intratumoral therapy that can enhance antigen presentation and recruit CD8 T cells, which are required for the antitumor efficacy. We identify a Tavo treatment-related gene signature associated with improved outcomes and conversion of nonresponsive tumors, potentially even beyond TNBC.&lt;/p&gt;&lt;/div&gt;
TAG (2022)

Analog and mixed-signal (AMS) circuit designs still rely on human design expertise. Machine learning has been assisting circuit design automation by replacing human experience with artificial intelligence. This paper presents TAG, a new paradigm of learning the circuit representation from layouts leveraging Text, self Attention and Graph. The embedding network model learns spatial information without manual labeling. We introduce text embedding and a self-attention mechanism to AMS circuit learning. Experimental results demonstrate the ability to predict layout distances between instances with industrial FinFET technology benchmarks. The effectiveness of the circuit representation is verified by showing the transferability to three other learning tasks with limited data in the case studies: layout matching prediction, wirelength estimation, and net parasitic capacitance prediction.
Highly tunable large-core single-mode liquid-crystal photonic bandgap fiber (2006)

We demonstrate a highly tunable photonic bandgap fiber, which has a large-core diameter of 25 microm and an effective mode area of 440 microm2. The tunability is achieved by infiltrating the air holes of a photonic crystal fiber with an optimized liquid-crystal mixture having a large temperature gradient of the refractive indices at room temperature. A bandgap tuning sensitivity of 27 nm/degrees C is achieved at room temperature. The insertion loss is estimated to be less than 0.5 dB and caused mainly by coupling loss between the index-guided mode and the bandgap-guided mode.