gebhart/patrepeval huggingface dataset:
New method for recording digital holograms (2013)

Fourier incoherent single-channel holography can record spatially incoherent digital holograms, avoiding the twin-image problem. This could enable the development of instruments such as holographic telescopes and video cameras.
Luminescence Quenching by O2 of a Ru2+ Complex Attached to Zeolite L (2006)

Photonic antenna: Ru-based stopcocks are electrostatically bound to the negatively charged one-dimensional channels of zeolite L crystals (see figure). The authors show that the quenching of the luminescence of the stopcock molecule is much weaker when it is bound to zeolite L.
You read what you value (2014)

This paper presents an experiment on the relationship between personal values and reading interests of online articles. Results suggest that individuals' values can predict their topical interests. For example, holding stronger universalism values predict interests towards environmental articles, whereas holding stronger achievement values predict interest towards work-related articles. Findings demonstrate the possibility of targeting based on individuals' personal values, but also highlight certain challenges and limitations when applying this approach for online content.
Antibody Targeting of Cathepsin S Inhibits Angiogenesis and Synergistically Enhances Anti-VEGF (2010)

Taken together, this data demonstrates that the antibody-mediated targeting of cathepsin S represents a novel method of inhibiting angiogenesis. Furthermore, when used in combination with anti-VEGF therapies, Fsn0503 has the potential to significantly enhance current treatments of tumour neovascularisation and may also be of use in the treatment of other conditions associated with inappropriate angiogenesis.
Lewis Blood Group Antigens in Salivary Glands and Stratified Epithelium: Lack of Regulation of Lewis Antigen Expression in Ductal and Buccal Mucosal Lining Epithelia (1991)

The expression of Lewis antigens is thought to be controlled by the Secretor and Lewis genes. While secretor status is known to regulate the expression of ABH antigens in many tissues, few studies have attempted to correlate Lewis antigen expression on erythrocytes and saliva with that of epithelial tissues. We examined the expression of Lewis a and b and related antigens in human epithelium of minor salivary glands and labial nonkeratinized oral mucosae from 16 individuals by immunohistology using monoclonal antibodies. The expression of these antigens, as detected by monoclonal antibodies (MAbs) used, was correlated with erythrocyte phenotype and saliva secretor status. In acinar cells of glands, Le^b antigen was expressed only in secretors, and Le^a only in nonsecretors. However, in gland ducts and oral mucosae, Le^b was found in both secretors and nonsecretors, as well as in 2 cases of Le^a-b-, secretors. Thus, antigen expression in acinar cells of minor salivary glands was correlated with the predicted genotypes, whereas inappropriate expression of Le^b antigen was found in epithelial cells of gland ducts and oral mucosae. The present data indicate that the Lewis blood group phenotype is regulated differently in duct cells and stratified epithelium than in saliva and erythrocytes.
Carbon Anode Material from Biomass Pyrolysis Oil (2022)

Lithium-ion batteries (LIB) are an important component of electric vehicles and sodium-ion batteries (SIB) are an attractive alternative for grid electric storage. We are investigating a novel approach to synthesizing the carbon anode materials for these batteries from biomass pyrolysis oil as part of conversion processes to produce biofuels. Graphite is used as anode material in LIB and is exclusively produced from petroleum residue or mined mineral carbon. We have synthesized drop-in graphite by coking the heavy residual oil from the distillation of catalytic fast pyrolysis oil and by catalytic graphitizing raw pyrolysis oil. XRD and Raman spectroscopies were used to verify the production of high purity crystalline graphite. Figure 1 shows typical XRD spectra of the bio-graphite compared to commercial material as well as the charge/discharge cycle. Graphite particle sizes and morphologies were adjusted to improve performance using jet milling and carbon coating. The bio-graphite delivered a high capacity (335 mAh/g) when tested in a graphite half-cell. Full cell coin cell experiments were also conducted to verify the observations from half-cell testing. The high value of graphite (>$9/kg) can positively impact the economics of biofuels production and can be an important part of a future circular carbon economy. We have also investigated synthesizing hard carbon from pyrolysis oil for use as anode material in SIB. These batteries are not commercially mature but have great promise in grid storage and use earth abundant elements. We have demonstrated that pyrolysis oil can be used to synthesize hard carbon, which was subsequently be used in SIB experiments. This material achieved a sodium-ion capacity of 250 mAh/g and a first cycle efficiency of 78%, with opportunities to further optimize this performance from optimizing the composition of the pyrolysis oil to shaping the hard carbon particles. As with graphite, hard carbon is a high value (> $10/kg) material that could facilitate biofuels production.
Predicting patterns of epicardial potentials during ventricular fibrillation (1995)

Ventricular fibrillation (VF) is a fatal cardiac arrhythmia, characterized by uncoordinated propagation of activation wavefronts in the ventricular myocardium. Short-term predictions of epicardial potential fields during VF in pigs were attempted using linear techniques, and prediction accuracy was measured at various stages during sustained episodes. VF was induced in five pigs via premature electrical stimulation. Unipolar electrograms were recorded from an epicardial array of 506 electrodes in a 22 x 23 array with 1-mm spacing. Optimal spatial basis functions (modes) and time-varying weighting coefficients were found using the Karhunen-Loeve decomposition. Linear autoregressive (AR) models incorporating the dynamics of only a few spatial modes led to predicted patterns that were qualitatively similar to observed patterns. Predictions were made 0.256 s into the future, based on 0.768 s of past data, over an area of approximately 5 cm2 on the ventricular epicardium. The mean squared error of predictions varied from as much as 1.23 to as little as 0.14, normalized to the variance of the actual data. Inconsistency in long-term forcasts is partly due to the limitations of linear AR models. Changes in predictability, however, were consistent. Predictability varied inversely with spatial complexity, as measured by the mean squared error of a five-mode approximation. Predictability also increased significantly during the first minute of VF.
Humidity dependency of the thermal phase transition of a cyano bridged Co–W bimetal assembly (2014)

A three-dimensional cyano-bridged Co–W bimetal assembly shows the humidity-dependent phase transition due to desorption or absorption of water molecules.
Spt4 selectively regulates the expression of C9orf72 sense and antisense mutant transcripts (2016)

An expanded hexanucleotide repeat in C9orf72 causes amyotrophic lateral sclerosis and frontotemporal dementia (c9FTD/ALS). Therapeutics are being developed to target RNAs containing the expanded repeat sequence (GGGGCC); however, this approach is complicated by the presence of antisense strand transcription of expanded GGCCCC repeats. We found that targeting the transcription elongation factor Spt4 selectively decreased production of both sense and antisense expanded transcripts, as well as their translated dipeptide repeat (DPR) products, and also mitigated degeneration in animal models. Knockdown of SUPT4H1, the human Spt4 ortholog, similarly decreased production of sense and antisense RNA foci, as well as DPR proteins, in patient cells. Therapeutic targeting of a single factor to eliminate c9FTD/ALS pathological features offers advantages over approaches that require targeting sense and antisense repeats separately.
Evolutionary mechanism leading to the multi-cagA genotype in Helicobacter pylori (2019)

Infection with CagA+ Helicobacter pylori strains is linked to an increased risk for gastric diseases, including gastric cancer. Recent evidence indicates that dynamic expansion and contraction of cagA copy number may serve as a novel mechanism to enhance disease development. Herein, comparative genomic analysis divided hpEurope into two groups: hpEurope/type-A and type-B. Only hpEurope/type-B displayed the multi-cagA genotype. Further analysis showed that cagPAI appears to have been independently introduced into two different H. pylori types, termed pre-type-A and pre-type-B, which consequently evolved to cagPAI type-A and type-B, respectively; importantly, all multi-cagA genotype strains displayed cagPAI type-B. Two direct cagA-flanking repeats of a genetic element termed CHA-ud were essential for the multi-cagA genotype in strain PMSS1 (hpEurope/type-B and cagPAI type-B). Furthermore, introduction of this genetic element into strain G27 (hpEurope/type-A and cagPAI type-A) was sufficient to generate the multi-cagA genotype. The critical steps in the evolution of the multi-cagA genotype involved creation of CHA-ud at cagA upstream in cagPAI type-B strains followed by its duplication to cagA downstream. En masse, elucidation of the mechanism by which H. pylori evolved to carry multiple copies of cagA helps to provide a better understanding of how this ancient pathogen interacts with its host.
Deep learning enables fast, gentle STED microscopy (2023)

STED microscopy is widely used to image subcellular structures with super-resolution. Here, we report that restoring STED images with deep learning can mitigate photobleaching and photodamage by reducing the pixel dwell time by one or two orders of magnitude. Our method allows for efficient and robust restoration of noisy 2D and 3D STED images with multiple targets and facilitates long-term imaging of mitochondrial dynamics.
Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers (2008)

clinicaltrials.gov identifier: NCT00006392.
The Val192Leu mutation in the alpha-subunit of beta-hexosaminidase A is not associated with the B1-variant form of Tay-Sachs disease. (1996)

Substitution mutations adversely affecting the alpha-subunit of beta-hexosaminidase A (alphabeta) (EC 3.2.1.52) result in Tay-Sachs disease. The majority affect the initial folding of the pro-alpha chain in the endoplasmic reticulum, resulting in its retention and degradation. A much less common occurrence is a mutation that specifically affects an "active-site" residue necessary for substrate binding and/or catalysis. In this case, hexosaminidase A is present in the lysosome, but it lacks all alpha-specific activity. This biochemical phenotype is referred to as the "B1-variant form" of Tay-Sachs disease. Kinetic analysis of suspected B1-variant mutations is complex because hexosaminidase A is heterodimeric and both subunits possess similar active sites. In this report, we examine a previously identified B1-variant mutation, alpha-Val192Leu. Chinese hamster ovary cells were permanently cotransfected with an alpha-cDNA-construct encoding the substitution and a mutant beta-cDNA (beta-Arg211Lys), encoding a beta-subunit that is inactive but normal in all other respects. We were surprised to find that the Val192Leu substitution, produced a pro-alpha chain that did not form alpha-beta dimers and was not transported to the lysosome. Finally, we reexamined the hexosaminidase activity and protein levels in the fibroblasts from the original patient. These data were also not consistent with the biochemical phenotype of the B1 variant of Tay-Sachs disease previously reported to be present. Thus, we conclude that the Val192Leu substitution does not specifically affect the alpha-active site.
Stochastic Game for Wireless Network Virtualization (2012)

We propose a new framework for wireless network virtualization. In this framework, service providers (SPs) and the network operator (NO) are decoupled from each other: The NO is solely responsible for spectrum management, and SPs are responsible for quality-of-service (QoS) management for their own users. SPs compete for the shared wireless resources to satisfy their distinct service objectives and constraints. We model the dynamic interactions among SPs and the NO as a stochastic game. SPs bid for the resources via dynamically announcing their value functions. The game is regulated by the NO through: 1) sum-utility optimization under rate region constraints; 2) enforcement of Vickrey-Clarke-Groves (VCG) mechanism for pricing the instantaneous rate consumption; and 3) declaration of conjectured prices for future resource consumption. We prove that there exists one Nash equilibrium in the conjectural prices that is efficient, i.e., the sum-utility is maximized. Thus, the NO has the incentive to compute the equilibrium point and feedback to SPs. Given the conjectural prices and the VCG mechanism, we also show that SPs must reveal their truthful value functions at each step to maximize their long-term utilities. As another major contribution, we develop an online learning algorithm that allows the SPs to update the value functions and the NO to update the conjectural prices iteratively. Thus, the proposed framework can deal with unknown dynamics in traffic characteristics and channel conditions. We present simulation results to show the convergence to the Nash equilibrium prices under various dynamic traffic and channel conditions.
Porcine oocytes denuded before maturation can develop to the blastocyst stage if provided a cumulous cell-derived coculture system1 (2010)

The physiological role of cumulus cells (CC) surrounding oocytes is particularly important for normal cytoplasmic maturation of oocytes. However, removal of CC from oocytes is inevitable for some embryo manipulation techniques, such as germinal vesicle (GV) transfer, somatic cell haploidization, and oocyte cryopreservation. The present study was designed to determine an optimal method to culture porcine denuded oocytes (DO). The results indicated CC from cumulus-oocyte complexes at the GV stage (GVCC) or at the metaphase II stage, and mural granulosa cells could not improve the maturation of DO. However, GVCC could enhance the development of matured porcine DO after fertilization; the percentage of blastocysts was increased from 1.1 to 17.2% (P < 0.05), and the relative value of the x-axis and y-axis of spindles was also increased (P < 0.05). Coculture with GVCC had no effect on the distribution of mitochondria and cortical granules. The results contribute to our understanding of the mechanisms by which CC promote oocyte maturation and contribute to optimization of protocols for in vitro maturation of DO.
The PLEX Cards and its techniques as sources of inspiration when designing for playfulness (2012)

Playfulness can be observed in all areas of human activity. It is an attitude of making activities more enjoyable. Designing for playfulness involves creating objects that elicit a playful approach and provide enjoyable experiences. In this paper, we introduce the design and evaluation of the PLEX Cards and its two related idea generation techniques. The cards were created to communicate the 22 categories of a playful experiences framework to designers and other stakeholders who wish to design for playfulness. We have evaluated the helpfulness of both the cards and their associated techniques in two studies. The results show that the PLEX Cards and its associated techniques are valuable sources of inspiration when designing for playfulness.
Lasing and reflectance measurement on a photonic band gap laser (2002)

We report the realization of photonic band gap (PBG) edge-emitting-laser in the optical regime. We not only observe lasing but also establish that the PBG structure, built in the sample, exhibits high reflectance at the lasing wavelength. We believe that we are the first one to do so.
A Novel Grid-forming Voltage Control Strategy for Supplying Unbalanced Microgrid Loads Using Inverter-based Resources (2022)

This paper presents a novel grid-forming voltage control strategy for a battery energy storage system to maintain balanced three-phase output voltages when serving unbalanced loads. A stationary reference frame <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$(\alpha\beta)$</tex> based control scheme is proposed to regulate positive-sequence and negative-sequence voltages. Compared with the conventional rotating reference frame <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$(dq)$</tex> based control scheme, the proposed scheme shows better dynamic performance. Then, we analyze the system zero-sequence network and propose adding a grounding transformer to the <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$\mathbf{Y}/\mathbf{Yg}$</tex> connected output transformer to further reduce the voltage unbalance at the point of common coupling. The simulation results demonstrate the effective performance of the proposed voltage control scheme. Based on the results, the power-voltage unbalance curve is derived for different output transformer configurations to establish the relationship between the power unbalance limit and the voltage unbalance limit for microgrid power scheduling.
Volatile Profile Comparison of USDA Sweet Orange-like Hybrids versus ‘Hamlin’ and ‘Ambersweet’ (2014)

Six ‘Ambersweet’-derived hybrids, similar to sweet orange fruit size, color, and taste and potential as new sweet orange cultivars, were selected to determine their fruit categorization by comparison of their volatile profiles with the parent and ‘Hamlin’, a typical sweet orange. All hybrids are at least ½ sweet orange and varying amounts of mandarin, grapefruit, Poncirus trifoliata , and sour orange in each pedigree. In total, 135 volatiles were detected in the eight hybrid lines/commercial cultivars over two harvests, and 20 compounds were detected in all samples, including terpenes (limonene, β-myrcene, α-pinene, α-terpinene, α-terpineol, and linalool), esters (ethyl butanote, ethyl pentanoate, and ethyl acetate), aldehydes (acetaldehyde, hexanal, and nonanal), and alcohols (ethanol and hexanol). Total abundance of volatiles in January-harvested fruits averaged 30% higher than for fruits of the same trees harvested in November. ‘Ambersweet’ contained the highest total amount of volatiles (mainly as a result of very high levels of monoterpenes), and of them, nootkatone and six other compounds were not detected in any of the hybrids, and some of them were also not detected in ‘Hamlin’. On the other hand, 12 compounds, including pentanal, ethyl 2-butenoate, and ethyl nonanoate, were not detected in ‘Ambersweet’ but were found in ‘Hamlin’ and some of the hybrids. Cluster analysis separated the cultivar/hybrid and harvest time combinations into three clusters. FF-1-76-50, FF-1-76-52 and January FF-1-75-55, all with the same parents (‘Ambersweet’ × FF-1-30-52), were close to FF-1-65-55, but they were separated from ‘Hamlin’ and further separated from ‘Ambersweet’. The cluster containing ‘Hamlin’ has three subclusters: January ‘Hamlin’ and November FF-1-74-14, a hybrid with one-eighth P. trifoliata , which includes a slight off-flavor frequently found in P. trifoliata hybrids, independent of each other, and both were separated from a group of November ‘Hamlin’, FF-1-64-97, and FF-1-75-55. The cluster containing ‘Ambersweet’ included January FF-1-64-97. A principle component analysis (PCA) separated ‘Ambersweet’ from all hybrids and ‘Hamlin’ along the PC1 axis and separated November harvests from January harvests along PC2. This volatile analysis supports the classification of the hybrids as sweet orange.
A Bi-Criteria DSS Dedicated to Location Problems (2008)

In location problems we want to determine the best way to serve a set of clients, or communities, whose location and demand are known. This implies to decide the number and location of the facilities, the size or capacity of each facility, and the allocation of the demand points to the open facilities in order to optimize some objective function. The type of optimality criterion depends on the nature of the activities or of the equipment to be installed. Most location models deal with desirable facilities, such as warehouses, service and transportation centers, emergency services, and so forth, which interacts with the customers and where usually travel is involved. The typical criteria for such decisions include minimizing some function of the distances between facilities and/or clients. However, during the last two or three decades, those responsible for the areas overall development, where the new equipment is going to be located (i.e., central government, local authorities) as well as those living there, are showing an increasing interest in preserving the area’s quality of life.
Metal Nanoparticle-Decorated Germanane for Selective Photocatalytic Aerobic Oxidation of Benzyl Alcohol (2022)

Two dimensional materials such as germanane have attracted substantial research interest due to their unique chemical, optical, and electronic properties. A variety of methods for introducing diverse functionalities to their surfaces have been reported and these materials have been exploted as photocatalysts. Herein, we report the preparation of metal nanoparticle (Au, Ag, Cu, Pd, Pt) decorated germanane (M@GeNSs) via a facile surface mediated reduction and investigate their structure, composition, as well morphology using X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS) and transmission electron microscopy (TEM). These functional materials were subsequently explored as photocatalysts for selective visible light-induced oxidation of benzyl alcohol to benzaldehyde as freestanding nanosystems and thin films and a reaction mechanism of the photocatalytic oxidation of benzyl alcohol is proposed.
Collaboration, workshops, and symposia (2017)

Readers may have noticed the presence of a March issue of Neurology ® Genetics that added to the customary bimonthly publication schedule. The March issue is a supplement focused on research presented by the International Stroke Genetics Consortium (ISGC).
A photonic-plasmonic mode converter using mode-coupling-based polarization rotation for metal-inserted silicon platform (2016)

We present a photonic-plasmonic mode converter using modecoupling-based polarization rotation for connecting a silicon wire and hybrid plasmonic waveguides on a metal-inserted silicon platform. By using the polarization rotator based on defect-introduced silicon wire waveguide, the proposed mode converter can convert the photonic TE mode into the hybrid plasmonic TM mode. At the beginning, to identify a cross-sectional structure for polarization conversion, we investigate the hybrid parameters that determine the degree of mode rotation using the two-dimensional vector finite element method. Next, using the three-dimensional vector finite element method, we investigate the conversion characteristics of the whole device including input and output ports. Numerical results show that the extinction ratio of 46 dB and the insertion loss of 0.36 dB are achieved. The tolerance of the defect is also numerically evaluated. Our proposed mode converter can reduce insertion losses compared to conventional mode converters based on a taper-introduced butt joint structure.