gebhart/patrepeval huggingface dataset:
Nickel vapor-olefin chemistry. 2. Binary perfluoroethylenenickel complexes (C2F4)nNi (where n = 1, 2, or 3). Evidence for a destabilizing effect in high stoichiometry perfluoroolefin complexes (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNickel vapor-olefin chemistry. 2. Binary perfluoroethylenenickel complexes (C2F4)nNi (where n = 1, 2, or 3). Evidence for a destabilizing effect in high stoichiometry perfluoroolefin complexesG. A. Ozin and W. J. PowerCite this: Inorg. Chem. 1977, 16, 11, 2864–2871Publication Date (Print):November 1, 1977Publication History Published online1 May 2002Published inissue 1 November 1977https://pubs.acs.org/doi/10.1021/ic50177a039https://doi.org/10.1021/ic50177a039research-articleACS PublicationsRequest reuse permissionsArticle Views46Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
S-1360 Shionogi-GlaxoSmithKline. (2003)

Shionogi and GlaxoSmithKline, as the joint venture company Shionogi-GlaxoSmithKline Pharmaceuticals, is developing S-1360, an HIV integrase inhibitor as a potential treatment for HIV infection. As of October 2002, phase II trials were ongoing and launch is expected in 2004/2005.
Characterization of the Mouse β maj Globin Transcription Termination Region: a Spacing Sequence is Required Between the Poly(A) Signal Sequence and Multiple Downstream Termination Elements (1993)

For the majority of mRNA encoding eukaryotic transcription units, there is little or no knowledge of the elements responsible for transcription termination or how they may interact with RNA polymerase. In this report, we have used recombinant adenovirus reporter vectors to characterize the mouse beta maj globin sequence elements that cause transcription termination. Within the globin 3' termination region, we have identified at least three sequence elements which induce significant levels of transcription termination (> 50%). The smallest functionally active element (64% termination) is 69 bp in length. The natural arrangement of these elements results in a cumulative termination which is greater than 90%. Recognition of the termination elements by RNA polymerase II depends on the presence of a functional poly(A) signal sequence. We demonstrate that efficient transcription termination depends on appropriate spacing between the poly(A) signal sequence and the termination element.
High-capacity IF-over-fiber transmission technology for next-generation mobile front-haul links (2019)

This invited paper discusses the potential of the Intermediate Frequency-over-Fiber (IFoF) technology for future mobile fronthaul links. First, we explain the fundamental of IFoF and its advantages over the conventional digital-based schemes such as Common Public Radio Interface (CPRI) from the point view of centralized radio access network (C-RAN) architecture. Then, our recent results including the experimental demonstration of the 1-Tb/s CPRI-equivalent-rate transmission with a transmitter composed of parallel intensity/phase (IM/PM) modulators are presented.
[Angiotensin type 1 receptor blocker reduced proteinuria in patients of focal glomerular sclerosis]. (2004)

We report three cases of focal glomerular sclerosis (FGS) with proteinuria that improved with the administration of angiotensin type 1 receptor blocker (ARB, losartan or valsartan). These three patients were a 41-year-old male (case 1), a 22-year-old male (case 2) and a 47-year-old male (case 3), who showed proteinuria, renal dysfunction, and hyperlipidemia. In case 1, proteinuria and renal dysfunction were improved by losartan administration and low protein diet therapy. In case 2, losartan with steroid and immunosuppressant led to the complete remission of proteinuria, improvement of renal dysfunction and reduction of the glomerular injury score from repeat biopsy specimen by approximately 20%. In case 3, proteinuria was reduced by valsartan administration with steroid and immunosuppressant therapy. ARB treatment with steroid and immunosuppressant might be more effective on the reduction of proteinuria in FGS patients.
Ion Suppression (2016)

This document contains recommendations for terminology in mass spectrometry. Development of standard terms dates back to 1974 when the IUPAC Commission on Analytical Nomenclature issued recommendations on mass spectrometry terms and definitions. In 1978, the IUPAC Commission on Molecular Structure and Spectroscopy updated and extended the recommendations and made further recommendations regarding symbols, acronyms, and abbreviations. The IUPAC Physical Chemistry Division Commission on Molecular Structure and Spectroscopy’s Subcommittee on Mass Spectroscopy revised the recommended terms in 1991 and appended terms relating to vacuum technology. Some additional terms related to tandem mass spectrometry were added in 1993 and accelerator mass spectrometry in 1994. Owing to the rapid expansion of the field in the intervening years, particularly in mass spectrometry of biomolecules, a further revision of the recommendations has become necessary. This document contains a comprehensive revision of mass spectrometry terminology that represents the current consensus of the mass spectrometry community.
A Study of Diversion Using Polymer-Based In-Situ-Gelled Acids Systems (2010)

In-situ gelled acids that are based on polymers have been used in the field for several years, and were the subject of many lab studies. These acids used in stages to block the treated zone and forcing the next regular acid stages to the untreated zones. An extensive literature survey reveals that there are conflicting opinions about using these acids. On one hand, these acids were used in the field, with mixed results. On the other hand, recent lab work indicated that these acids can cause damage under certain conditions.The ability of polymer-based in-situ gelled acids to divert regular acids was studied using parallel core flood setup. The sequence of the injection involved In-situ gelled acid at 5 wt% HCl stage followed by regular acid at 15 wt% HCl until acid breakthrough. Experimental results show that even for nearly the same permeability formation (1:1.1), regular acid preferred to flow only through the high permeability zones. Therefore, diversion was needed for all acid treatments. At an injection rate of 1 cm3/min, in-situ gelled acid plugged the two cores. For low permeability contrast (1:2), polymer was able to divert the acid with permeability enhancement in both cores.For high permeability contrast (1: 20 up to 25), in-situ gelled acid was able to divert the acid only at injection rate less than 10 cm3/min. However, at higher injection rates, in-situ gelled acid was not able to build enough pressure that could force the regular acid into the low permeability core. Increasing the injection rate reduced the viscosity of the in-situ gelled acid. Therefore, acid injection rate should be determined based on the expected fluid viscosity in the formation. The results obtained can be used to better design acid treatments in carbonate reservoirs.
Impact of digital miniaturization and networked topologies on access to next generation telecommunication by people with visual disabilities. (1999)

In the past, telecommunication technologies did not present any particular problem for persons with visual disabilities. The telephones themselves were auditory in nature and could be operated by touch. As telecommunication begins to incorporate video and as telecommunication devices become more complex (including the incorporation of visual displays), new barriers are appearing. Fortunately, advancing technologies are also providing new opportunities for access. The rapidly shrinking size and cost of electronics is allowing us to build intelligence and flexibility into telecommunication products. Advances will soon allow voice to be incorporated into most devices. In addition, clever use of networks and network-based services will allow access features to be built directly into the network, providing access to key visual information. As a result, future telecommunication systems can be more accessible than technologies of the past-if they are implemented correctly.
Cytotoxic T lymphocyte-associated antigen 4 blockade with ipilimumab: Long-term follow-up of 179 patients with metastatic melanoma. (2010)

8544 Background: We have previously shown objective clinical responses in patients with metastatic melanoma treated with CTLA-4 blockade using ipilimumab. We have treated 179 patients in 3 separate clinical trials and now have long-term follow-up to evaluate the durability and unique features of this immunotherapy. Methods: A total of 179 patients with metastatic melanoma were treated in 3 trials: In Protocol 1, 56 patients received ipilimumab with gp100 peptide vaccines. In Protocol 2, 36 patients received ipilimumab with high-dose interleukin-2 (IL-2). In Protocol 3, 87 patients received intra-patient dose escalation of ipilimumab and were randomized to receive gp100 peptides. We have updated and analyzed the follow-up and survival data for these trials. Results: With median follow-up for Protocol 1, 2, and 3 being 80, 71, and 60 months, median survival was 15, 16, and 13 months, respectively. Objective tumor regression was 12% for Protocol 1, 25% for Protocol 2, and 21% for Protocol 3. Patients in Protocol 2 had a 17% complete response rate (6 patients: 77+, 74+, 72+, 71+, 71+, and 69+ months), as compared to 7% in Protocol 1 (4 patients: 82+, 81+, 79+, and 66+ months) and 8% in Protocol 3 (5 patients: 64+, 63+, 62+, 60+, and 55+ months); all complete responses are ongoing. Many patients who eventually became complete responders had continual tumor shrinkage after stopping therapy. Conclusions: CTLA-4 blockade with ipilimumab can achieve durable objective tumor regression in patients with metastatic melanoma. The combination of ipilimumab and IL-2 appears to have an increased complete response rate, although this needs to be tested in a prospective randomized trial. This report represents the largest single-institution experience with the longest follow-up for this agent; our results support its role as a viable treatment option for patients with metastatic melanoma. No significant financial relationships to disclose.
DNA movement in sub-20 nm nanoslits (2007)

The movement of XbaI digested O-DNA in 20 nanometer and O-DNA in 12 nanometer high slits was investigated. We found that DNA moved intermittently and following preferential pathways, indicating an important influence of surface roughness. From these intermittent movements two different mobilities were calculated, the total averaged mobilities and averaged mobilities between the intermittent sticking events. The friction coefficient per unit length was calculated from the latter mobilities. A three order of magnitude increase was found for the 12 nm slits compared to the theoretical value. The mobility furthermore differs less than one order of magnitude between 20 nm and 12 nm slits, and the influence of varying the ionic strength of the buffer was not significant. This work is the first time DNA movement in such shallow constrictions is investigated.
segDeepM: Exploiting Segmentation and Context in Deep Neural Networks for Object Detection (2015)

In this paper, we propose an approach that exploits object segmentation in order to improve the accuracy of object detection. We frame the problem as inference in a Markov Random Field, in which each detection hypothesis scores object appearance as well as contextual information using Convolutional Neural Networks, and allows the hypothesis to choose and score a segment out of a large pool of accurate object segmentation proposals. This enables the detector to incorporate additional evidence when it is available and thus results in more accurate detections. Our experiments show an improvement of 4.1% in mAP over the R-CNN baseline on PASCAL VOC 2010, and 3.4% over the current state-of-the-art, demonstrating the power of our approach.
Enhancement of the Stability and Anti-DPPIV Activity of Hempseed Hydrolysates Through Self-Assembling Peptide-Based Hydrogels (2019)

Although there is an increasing interest for bioactive food protein hydrolysates as valuable ingredients for functional food and dietary supplement formulations, their potential applications are hampered by their insufficient stability in physiological conditions. In this study, an innovative strategy based on nanomaterials was developed in order to increase the hempseed hydrolysate stability and the anti-diabetic properties, through their encapsulation into ionic self-complementary RADA16 peptide based-hydrogels. Atomic force microscope (AFM) morphological analysis indicated that the new nanomaterials were composed of a nanofibril network, whose increased diameter in respect to native RADA16 suggests the presence of transient non-covalent interactions among the RADA16 supramolecular assemblies and the embedded hempseed peptides. Structural analysis by FT-IR spectroscopy indicated typical β-sheet signatures. The RADA16-hempseed protein hydrolysate hydrogel was shown to act as a novel dipeptidyl peptidase IV (DPPIV) inhibitor in different biological assays. Finally, this nanoformulation was used as a drug delivery system of the anti-diabetic drug sitagliptin, helping to reduce its dosage and eventually associated side-effects.
Novel methods for semantic and aesthetic multimedia retrieval (2013)

A l'ère d'Internet, la classification informatisée des images est d'une importance cruciale pour l’utilisation efficace de l'énorme quantité de données visuelles qui sont disponibles. Mais comment les ordinateurs peuvent-ils comprendre la signification d'une image? La Recherche d’Information Multimédia (RIM) est un domaine de recherche qui vise à construire des systèmes capables de reconnaître automatiquement le contenu d’une image. D'abord, des caractéristiques de bas niveau sont extraites et regroupées en signatures visuelles compactes. Ensuite, des techniques d'apprentissage automatique construisent des modèles qui font la distinction entre les différentes catégories d'images à partir de ces signatures. Ces modèles sont finalement utilisés pour reconnaître les propriétés d'une nouvelle image. Malgré les progrès dans le domaine, ces systèmes ont des performances en général limitées. Dans cette thèse, nous concevons un ensemble de contributions originales pour chaque étape de la chaîne RIM, en explorant des techniques provenant d'une variété de domaines qui ne sont pas traditionnellement liés avec le MMIR. Par exemple, nous empruntons la notion de saillance et l'utilisons pour construire des caractéristiques de bas niveau. Nous employons la théorie des Copulae étudiée en statistique économique, pour l'agrégation des caractéristiques. Nous réutilisons la notion de pertinence graduée, populaire dans le classement des pages Web, pour la récupération visuelle. Le manuscrit détaille nos solutions novatrices et montre leur efficacité pour la catégorisation d'image et de vidéo, et l’évaluation de l'esthétique.
Interactions between cancer cells and normal cells via miRNAs in extracellular vesicles (2015)

MicroRNAs (miRNAs) exhibit many functions in biological activities. Recent studies have shown that miRNAs exist outside cells and are transferred between cells. Extracellular miRNAs are protected from ribonucleases found in body fluids through binding to specific proteins or by being encapsulated in lipid bilayer vesicles. Here, we review the mechanisms of the secretion and uptake as well as the functions of extracellular miRNAs, particularly those encapsulated in extracellular vesicles. Extracellular vesicles are related to cancer progression, and some miRNAs in extracellular vesicles are associated with cancer cells. We describe the transfer of cancer-related miRNAs between cancer cells and non-cancerous cells. Finally, we discuss the anticipated applications of miRNAs present in extracellular vesicles in diagnostics and therapeutics.
Macrophages – Controlling the Bifurcation Between Tumor Existence or Regression (2023)

Macrophages are multifunctional cells that are employed by the tumor to further its growth and adaptation. While tumor-associated macrophages (TAMs) have widely diverse phenotypes, tumors coevolve with the ones that can promote tumorigenesis. Functionally, TAMs/myeloid cells constitute the largest negative influence on the tumor microenvironment and need to be reprogrammed in order to enable successful anti-tumor response in most tumors. It is predicted that successful TAM repolarization has the potential to become a staple of immuno-oncology across most indications.
Urolithiasis, Endourology and Laparoscopy (2008)

No AccessJournal of UrologyAdult Urology1 Dec 2008Urolithiasis, Endourology and Laparoscopy Ralph V. ClaymanM.D. Ralph V. ClaymanRalph V. Clayman More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2008.08.094AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Trunk Muscle Training, Posture Fatigue, and Performance in Laparoscopic Surgery 1 : Comparison of neuromuscular injuries to the surgeon during hand-assisted and standard laparoscopic urologic surgery. J Endourol2005; 19: 377. Google Scholar 2 : Surgeons' perceptions and injuries during and after urologic laparoscopic surgery. Urology2008; 71: 404. Google Scholar © 2008 by American Urological AssociationFiguresReferencesRelatedDetails Volume 180Issue 6December 2008Page: 2512-2514 Advertisement Copyright & Permissions© 2008 by American Urological AssociationMetricsAuthor Information Ralph V. Clayman More articles by this author Expand All Advertisement PDF downloadLoading ...
Nonspeculative Bubbles in Experimental Asset Markets: Lack of Common Knowledge of Rationality vs. Actual Irrationality (2001)

We report the results of an experiment designed to study the role of speculation in the formation of bubbles and crashes in laboratory asset markets. In a setting in which speculation is not possible, bubbles and crashes are observed. The results suggest that the departures from fundamental values are not caused by the lack of common knowledge of rationality leading to speculation, but rather by behavior that itself exhibits elements of irrationality. Much of the trading activity that accompanies bubble formation, in markets where speculation is possible, is due to the fact that there is no other activity available for participants in the experiment.
Growth of Triple Negative and Progesterone Positive Breast Cancer Causes Oxidative Stress and Down-Regulates Neuroprotective Transcription Factor NPAS4 and NPAS4-Regulated Genes in Hippocampal Tissues of TumorGraft Mice—an Aging Connection (2018)

While the refinement of existing and the development of new chemotherapeutic regimens has significantly improved cancer treatment outcomes and patient survival, chemotherapy still causes many persistent side effects. Central nervous system (CNS) toxicity is of particular concern, as cancer patients experience significant deficits in memory, learning, cognition, and decision-making. These chemotherapy-induced cognitive changes are termed chemo brain, and manifest in more than half of cancer survivors. Moreover, recent studies have emerged suggesting that neurocognitive deficits manifest prior to cancer diagnosis and treatment, and thus may be associated with tumor presence, a phenomenon recently termed "tumor brain." To dissect the molecular mechanisms of tumor brain, we used TumorGraft<sup>TM</sup> models, wherein part of a patient's tumor is grafted into immune-deficient mice. Here, we analyzed molecular changes in the hippocampal tissues of mice carrying triple negative (TNBC) or progesterone receptor positive (PR+BC) xenografts. TNBC growth led to increased oxidative damage, as detected by elevated levels of 4-hydroxy-2-nonenal, a product of lipid peroxidation. Furthermore, the growth of TNBC and PR+BC tumors altered global gene expression in the murine hippocampus and affected multiple pathways implicated in PI3K-Akt and MAPK signaling, as well as other pathways crucial for the proper functioning of hippocampal neurons. TNBC and PR+BC tumor growth also led to a significant decrease in the levels of neuronal transcription factor NPAS4, a regulator that governs the expression of brain-derived neurotrophic factor (BDNF), and several other key brain neurotrophic factors and pro-survival molecules. The decreased expression of ERK1/2, NPAS4, and BDNF are also seen in neurodegenerative conditions and aging, and may constitute an important tumor brain mechanism.
Towards optimal ESD diodes in next generation bulk FinFET and GAA NW technology nodes (2017)

Beyond dimensional scaling, new process options in CMOS roadmap often result in degradation of ESD device performance. Using 3D TCAD and ESD characterization, the impacts of device architecture, middle-of-line contact scheme, and S/D epitaxy process options are explored on ESD diode performance in next generation bulk FF and GAA technologies.
Bioorthogonal Chemistries for Glycoprofiling and Beyond (2012)

The glycome is dynamically regulated during development and disease progression. The ability to detect changes in protein glycosylation, in tissue and serum samples as well as in vivo, is of considerable interest for biomarker identification and disease monitoring. This presentation will focus on our work toward profiling glycomic changes using proteomics and in vivo imaging techniques. Bioorthogonal chemistry is central to our approaches, which involve metabolic labeling of glycans with bioorthogonal functional groups followed by chemical tagging with affinity reagents, mass spectrometry tags or imaging probes. Fundamental principles of bioorthogonal reaction development will be discussed, along with applications in cancer biomarker discovery and glycan imaging during embryonic development.
Supplementary Figure 1 from Adoptive Transfer of Autologous Natural Killer Cells Leads to High Levels of Circulating Natural Killer Cells but Does Not Mediate Tumor Regression (2023)

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