gebhart/patrepeval huggingface dataset:
Dinamica Flessionale di sistemi continui traslanti: modellazione agli elementi finiti (2005)

Sommario Il presente lavoro e dedicato allo sviluppo di una metodologia di analisi numerica basata sulla discretizzazione agli elementi finiti per lo studio del comportamento dinamico flessionale di sistemi continui traslanti. In impianti con nastro flessibile, seghe a nastro, sistemi di trasmissione a cinghia, la dinamica dell’elemento traslante e affetta dalla velocita di traslazione. Tale comportamento e stato studiato in letteratura utilizzando la teoria dei continui oppure ricorrendo ad un approccio multibody. In questo lavoro e descritto un modello di discretizzazione agli elementi finiti che consente di stimare gli effetti considerati con potenze di calcolo limitate. Si evidenzia come la velocita di traslazione genera un effetto giroscopico e di riduzione della rigidezza flessionale. Il confronto con i modelli continui proposti in letteratura conferma l’affidabilita del modello proposto. Nella seconda parte del lavoro e riportato il confronto numerico-analitico di un sistema di trasmissione a cinghia con pulegge e tensionatore automatico. Il relativo diagramma di Campbell mette in luce come la velocita di traslazione comporta una diminuzione delle frequenze proprie flessionali con effetti non trascurabili nel campo di velocita di interesse.
Inactivation of SARS-CoV-2 by 2 commercially available Benzalkonium chloride-based hand sanitizers in comparison with an 80% ethanol-based hand sanitizer (2021)

These findings indicate that a commercial BAK hand hygiene formulation may be another effective means of inactivating the SARS-CoV-2 virus and could be considered as option for pandemic response.
A Qualitative Investigation Into Faith and LGBTQ Identities in a Nonclinical Sample of Readers of the Dear Abby Column (2021)

To better understand the relationship between faith and LGBTQ+ identity, we conducted a qualitative analysis of 86 respondents to a general question posed through the Dear Abby column. Responses were anonymized and analyzed using a grounded theory approach. Analysis revealed six themes, reflecting a diversity of lived experience from community rejection to acceptance, and self-rejection to feelings of acceptance by God. Despite frequent media portrayals of conflict between faith and LGBTQ+ identity, the reality is more complex, and faith and LGBTQ+ identity development can be complementary.
Genetic variants in the LAMA5 gene in pediatric nephrotic syndrome (2018)

We here identify recessive VUS in the gene LAMA5 in patients with partially treatment-responsive NS. More data will be needed to determine the impact of these VUS in disease management. However, familial occurrence of disease, data from genetic mapping and a mouse model that recapitulates the NS phenotypes suggest that these genetic variants may be inherited factors that contribute to the development of NS in pediatric patients.
Error-Recovery Service for the IEEE 802.11b Protocol (2006)

A service that allows the current IEEE 802.11b MAC protocol to perform a dynamic packet sizing and a forward error correction is proposed. This new service, called error recover service medium-access control (ERSMAC), is designed to allow the deployment of the IEEE 802.11b protocol in industrial environments characterized by high bit-error-rate (BER) and fast time variation. ERSMAC uses a maximum likelihood estimate of the BER to solve for the optimal packet size that maximizes the success probability of transmissions while minimizing the overhead cost. ERSMAC also implements an adaptive forward-error-correction scheme using Reed-Solomon (RS) code such that every retransmission attempt has a higher probability of success than the previous attempt due to its association with a stronger RS code. Finally, this paper shows that ERSMAC outperforms the original unmodified IEEE 802.11b protocol in terms of average throughput, average delay and efficiency.
Transforming Growth Factor β Receptor Endoglin Is Expressed in Cardiac Fibroblasts and Modulates Profibrogenic Actions of Angiotensin II (2004)

Angiotensin II (Ang II) is a powerful mediator of adverse cardiac remodeling and fibrosis. However, the mechanisms of Ang II-induced myocardial fibrosis remain to be clarified. We postulated that Ang II alters transforming growth factor beta (TGF-beta) receptor expression, specifically that of endoglin, and thereby modulates cardiac fibroblast (CF) collagen metabolism. Experiments were conducted using CF from adult Sprague Dawley rats to determine the expression of TGF-beta1 receptors including endoglin, and the role of Ang II type 1 (AT1) and type 2 (AT2) receptors, and MAPK p42/44 in this process. The functional role of endoglin in modulating Ang II effects on matrix metalloproteinase-1 (MMP-1) and type I collagen expression was also analyzed. Endoglin gene and protein expression were consistently identified in quiescent CFs. Ang II increased the expression of endoglin mRNA and protein in a concentration and time-dependent manner, with no effect on TGF-beta receptors I and II expression. This effect was AT1 receptor mediated, because AT1 receptor antagonists valsartan, candesartan, and losartan inhibited Ang II-induced endoglin expression, whereas the AT2 receptor antagonist PD123319 had no effect. MAPKp42/44 inhibition attenuated Ang II-induced endoglin expression. Ang II-induced decrease in MMP-1 protein expression and increase in type I collagen protein expression were both blocked by a specific endoglin antibody. Hence, our results indicate that endoglin is upregulated in CFs by Ang II via the AT1 receptor and modulates profibrotic effects of Ang II. These findings provide novel insights into Ang II-induced cardiac remodeling.
Tapered couplers for efficient interfacing between dielectric and photonic crystal waveguides (2001)

We design tapered waveguide junctions for coupling between photonic crystal and traditional dielectric waveguides and evaluate their transmission efficiency. While the transmission efficiency is less than 60% using no taper, the tapered couplers have over 90% power transmission. We show that different types of couplers are needed for efficient coupling into and out of photonic crystal waveguides.
Quantification of Surrogate Monoclonal Antibodies in Mouse Serum Using LC–MS/MS (2021)

<b>Background:</b> Surrogate monoclonal antibodies (mAbs) used in preclinical <i>in vivo</i> studies can be challenging to quantify due to lack of suitable immunoaffinity reagents or unavailability of the mAb protein sequence. Generic immunoaffinity reagents were evaluated to develop sensitive LC-MS/MS assays. Peptides of unknown sequence can be used for selective LC-MS quantification. <b>Results:</b> anti-mouse IgG1 was found to be an effective immunoaffinity reagent, enabling quantification of mouse IgG1 mAbs in mouse serum. Selective peptides of unknown sequence were applied for multiplex LC-MS quantification of two rat mAbs co-dosed in mouse. <b>Conclusion:</b> Generic anti-mouse IgG subtype-specific antibodies can be used to improve assay sensitivity and peptides of unknown sequence can be used to quantify surrogate mAbs when the mAb protein sequence in unavailable.
Translocation of radical sites by intramolecular 1,5-hydrogen atom transfer (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTranslocation of radical sites by intramolecular 1,5-hydrogen atom transferDennis P. Curran, Dooseop. Kim, Hong Tao. Liu, and Wang. ShenCite this: J. Am. Chem. Soc. 1988, 110, 17, 5900–5902Publication Date (Print):August 1, 1988Publication History Published online1 May 2002Published inissue 1 August 1988https://pubs.acs.org/doi/10.1021/ja00225a052https://doi.org/10.1021/ja00225a052research-articleACS PublicationsRequest reuse permissionsArticle Views2363Altmetric-Citations170LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Missing Piece in the Crystal Chemistry of Zn–Sb Secondary Phases in ZnO–Sb2O3–Bi2O3 Varistor Ceramics: Orthorhombic β-Zn7Sb2O12. An Experimental and Theoretical Study of the Crystal Structure and Its Thermal and Vibrational Spectroscopic Characterization (2021)

The ternary Zn-Sb oxide β-Zn<sub>7</sub>Sb<sub>2</sub>O<sub>12</sub> was prepared by solid state synthesis from ZnO and Sb<sub>2</sub>O<sub>3</sub> at 1250 °C and a reaction time of 168 h. The crystal structure of β-Zn<sub>7</sub>Sb<sub>2</sub>O<sub>12</sub> was solved from powder diffraction data by direct-space methods and was refined by the Rietveld technique. The title compound β-Zn<sub>7</sub>Sb<sub>2</sub>O<sub>12</sub> crystallizes in the orthorhombic space group <i>Cmme</i> with <i>a</i> = 1210.6(1) pm, <i>b</i> = 1856.7(1) pm, <i>c</i> = 852.2(1) pm, <i>V</i> = 1.9154(1) nm<sup>3</sup>, and eight formula units per unit cell. The structure can be described as a distorted cubic closest packing of oxide ions with Zn<sup>2+</sup> and Sb<sup>5+</sup> in the tetrahedral and octahedral interstitial sites. According to group-subgroup relations, the anion packing is directly derived from the spinel structure of α-Zn<sub>7</sub>Sb<sub>2</sub>O<sub>12</sub>; however, the occupation pattern of the interstitials is completely different than in the spinel structure type. The most prominent structural feature in β-Zn<sub>7</sub>Sb<sub>2</sub>O<sub>12</sub> is the clustering of all [ZnO<sub>4</sub>] polyhedra into a [Zn<sub>7</sub>O<sub>20</sub>] moiety representing an excerpt from the sphalerite structure. The structural model is corroborated by vibrational spectroscopy as well as density functional theory calculations. Thermal analysis reveals an irreversible phase transition of β-Zn<sub>7</sub>Sb<sub>2</sub>O<sub>12</sub> into the α-polymorph at 1330 °C.
Optical characterization of a leaky-mode polysilicon photodetector using near-field scaning optical microscopy (2006)

Near-field scanning optical microscopy was used to characterize the light absorption capability of a leaky-mode coupled polysilicon photodetector fabricated for CMOS on-chip optical interconnects. The observed results are in good agreement with modal calculations.
Variation at 2q35 (PNKD and TMBIM1) influences colorectal cancer risk and identifies a pleiotropic effect with inflammatory bowel disease (2016)

To identify new risk loci for colorectal cancer (CRC), we conducted a meta-analysis of seven genome-wide association studies (GWAS) with independent replication, totalling 13 656 CRC cases and 21 667 controls of European ancestry. The combined analysis identified a new risk association for CRC at 2q35 marked by rs992157 (P = 3.15 × 10−8, odds ratio = 1.10, 95% confidence interval = 1.06–1.13), which is intronic to PNKD (paroxysmal non-kinesigenic dyskinesia) and TMBIM1 (transmembrane BAX inhibitor motif containing 1). Intriguingly this susceptibility single-nucleotide polymorphism (SNP) is in strong linkage disequilibrium (r2 = 0.90, D′ = 0.96) with the previously discovered GWAS SNP rs2382817 for inflammatory bowel disease (IBD). Following on from this observation we examined for pleiotropy, or shared genetic susceptibility, between CRC and the 200 established IBD risk loci, identifying an additional 11 significant associations (false discovery rate [FDR]) &lt; 0.05). Our findings provide further insight into the biological basis of inherited genetic susceptibility to CRC, and identify risk factors that may influence the development of both CRC and IBD.
1,2,4-Triazol-3-yl-thiopropyl-tetrahydrobenzazepines:  A Series of Potent and Selective Dopamine D3Receptor Antagonists (2007)

The discovery of new highly potent and selective dopamine D3 receptor antagonists has recently permitted characterization of the role of the dopamine D3 receptor in a wide range of preclinical animal models. A novel series of 1,2,4-triazol-3-yl-thiopropyl-tetrahydrobenzazepines demonstrating a high level of D3 affinity and selectivity with an excellent pharmacokinetic profile is reported here. In particular, the pyrazolyl derivative 35 showed good oral bioavailability and brain penetration associated with high potency and selectivity in vitro. In vivo characterization of 35 confirmed that this compound blocks the expression of nicotine- and cocaine-conditioned place preference in the rat, prevents nicotine-triggered reinstatement of nicotine-seeking behavior in the rat, reduces oral operant alcohol self-administration in the mouse, increases extracellular levels of acetylcholine in the rat medial prefrontal cortex, and potentiates the amplitude of the relative cerebral blood volume response to d-amphetamine in a regionally specific manner in the rat brain.
Colectomy for Ulcerative Colitis in a Large Private Insurance Claims Database (2006)

Purpose: To describe the surgical and medical complications occurring within 180 days of colectomy in a population of privately insured individuals with ulcerative colitis (UC). Methods: This was a retrospective analysis of claims data of employees and dependents from several large corporations in the US (MarketScan) for the years 2001–2004 inclusive. The database included 357.5 million outpatient claims and 1.4 million inpatient admissions. We identified a cohort of patients (pts) with a diagnosis of UC who underwent colectomy. Colectomy types were classified into five categories: (1) total proctocolectomy (TPC) with ileal pouch-anal anastomosis (IPAA); (2) subtotal colectomy (SC) with ileostomy and Hartmann pouch or ileorectal anastomosis; (3) TPC with ileostomy; (4) segmental colectomy with ileal or colonic anastomosis; or (5) other partial colectomy (OPC). Pts were classified into those experiencing surgical/medical complications or not during the 180 days following their colectomy date. Procedures and diagnoses examined included: treatment of fistulas, abscess, sepsis/pneumonia/bacteremia, and revision of ileostomy or colostomy. Results: A total of 25586 UC pts were identified. The study sample includes 215 UC pts who had a CPT4 procedure code for colectomy and at least 180 days of pre- and post-colectomy follow-up. The pt group was 52% male (mean age 42.6 years). Pts were most often insured by a PPO (39%). UC colectomy pts (n = 215) experienced a variety of complications, including: fistulas (8.8%), abscesses (20.9%), sepsis/pneumonia/bacteremia (11.6%), and revision of ileostomy or colostomy (2.3%).Table: Complications by type of colectomy for 215 UC pts.Conclusions: This retrospective study of privately insured UC pts treated with a colectomy suggests frequent occurrence of complications post-colectomy. These results highlight the burden of post-operative complications in UC pts undergoing colectomy. Supported by Schering-Plough.
Phase noise mitigation in OFDMA uplink (2014)

This paper addresses the problem of the phase noise induced spectral spread in an OFDMA uplink scenario. Accompanied with power differences between the users at the receiver in a multiuser case, the phase noise induced spread causes performance degradation for users with low signal powers. This paper proposes a receiver-side digital signal processing methods to estimate and mitigate the spread caused by the transmitter-side phase noise. The introduced methods show a significant gain when compared with other conventional phase noise estimation and mitigation methods that are not designed especially for the multiuser scenario.
ChemInform Abstract: CHIRAL 1,4‐BENZODIAZEPINES PART 5, SYNTHESIS AND PROPERTIES OF 1,4‐BENZODIAZEPIN‐2‐ONES CONTAINING ALPHA‐AMINO ACIDS AS A PART OF THE 1,4‐DIAZEPINE RING (1974)

Abstract Aus dem Amino‐benzophenon (I) erhält man mit den geschützten Aminosäuren (II) die Substitutionsprodukte (III) bei der Kondensation in Gegenwart von Dicyclohe; xylcarbodiimid.
Increasing the Affinity Between Carbon-Coated LiFePO4/C Electrodes and Conventional Organic Electrolyte by Spontaneous Grafting of a Benzene-Trifluoromethylsulfonimide Moiety (2015)

The grafting of benzene-trifluoromethylsulfonimide groups on LiFePO4/C was achieved by spontaneous reduction of in situ generated diazonium ions of the corresponding 4-amino-benzene-trifluoromethylsulfonimide. The diazotization of 4-amino-benzene-trifluoromethylsulfonimide was a slow process that required a high concentration of precursors to promote the spontaneous grafting reaction. Contact angle measurements showed a hydrophilic surface was produced after the reaction that is consistent with grafting of benzene-trifluoromethylsulfonimide groups. Elemental analysis data revealed a 2.1 wt % loading of grafted molecules on the LiFePO4/C powder. Chemical oxidation of the cathode material during the grafting reaction was detected by X-ray diffraction and quantified by inductively coupled plasma atomic emission spectrometry. Surface modification improves the wettability of the cathode material, and better discharge capacities were obtained for modified electrodes at high C-rate. In addition, electrochemical impedance spectroscopy showed the resistance of the modified cathode was lower than that of the bare LiFePO4/C film electrode. Moreover, the modified cathode displayed superior capacity retention after 200 cycles of charge/discharge at 1 C.
ChemInform Abstract: Novel Entry to the Ergot Alkaloids via Ring Closing Metathesis. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Evolution of Stimulated Raman into Stimulated Compton Scattering of Laser Light via Wave Breaking of Plasma Waves (1995)

Experimental evidence for the evolution of stimulated Raman backscatter instability of laser light into stimulated Compton scattering in an initially cold plasma is presented using time and wave number resolved spectra, $w(t)$ and $w(k)$, of Thomson scattered light from plasma fluctuations. Supporting particle simulations show that the key to the spectral evolution is wave breaking of Raman plasmons, which accelerates some electrons up to 4 times the phase velocity, and the consequent return current of the bulk plasma electrons in the opposite direction.
1Tb/s and 800 Gb/s real-time transmission at 138 GBd over a deployed ROADM network with live traffic (2023)

We demonstrate real-time transmission using a single-carrier coherent pluggable at 138-GBd in a deployed network. We show 800 Gb/s over a record 2220 km and over 1422 km with 24 WSSs, and a record 1 Tb/s over 869 km.
Differential cytotoxicity, ER/oxidative stress, dysregulated AMPKα signaling, and mitochondrial stress by ethanol and its metabolites in human pancreatic acinar cells (2021)

EtOH and its metabolites, acetaldehyde and FAEEs, caused cytotoxicity, ER/oxidative and mitochondrial stress, and dysregulated AMPKα signaling, suggesting a key role of EtOH metabolism in the etiopathogenesis of ACP. Because oxidative EtOH metabolism is negligible in the exocrine pancreas, the pathogenesis of ACP could be attributable to the formation of FAEEs and related pancreatic acinar cell injury.
Optimization of the electromagnetic fields at the aperture of a wave guide horn by using a "floating" dielectric insert, in foam technology (2004)

This paper presents an innovative low cost solution to symmetrize E-plane and H-plane radiation patterns of conical waveguide horns. This solution takes benefit from the flexibility brought by foam technology. The design methodology, practical implementation and measurement results are presented.
The Effect of Vortex Formation on Left Ventricular Filling and Mitral Valve Efficiency (2006)

A new mechanism for quantifying the filling energetics in the left ventricle (LV) and past mechanical heart valves (MHV) is identified and presented. This mechanism is attributed to vortex formation dynamics past MHV leaflets. Recent studies support the conjecture that the natural healthy left ventricle (LV) performs in an optimum, energy-preserving manner by redirecting the flow with high efficiency. Yet to date, no quantitative proof has been presented. The present work provides quantitative results and validation of a theory based on the dynamics of vortex ring formation, which is governed by a critical formation number (FN) that corresponds to the dimensionless time at which the vortex ring has reached its maximum circulation content, in support of this hypothesis. Herein, several parameters (vortex ring circulation, vortex ring energy, critical FN, hydrodynamic efficiencies, vortex ring propagation speed) have been quantified and presented as a means of bridging the physics of vortex formation in the LV. In fact, the diastolic hydrodynamic efficiencies were found to be 60, 41, and 29%, respectively, for the porcine, anti-anatomical, and anatomical valve configurations. This assessment provides quantitative proof of vortex formation, which is dependent of valve design and orientation, being an important flow characteristic and associated to LV energetics. Time resolved digital particle image velocimetry with kilohertz sampling rate was used to study the ejection of fluid into the LV and resolve the spatiotemporal evolution of the flow. The clinical significance of this study is quantifying vortex formation and the critical FN that can potentially serve as a parameter to quantify the LV filling process and the performance of heart valves.
Metabolic engineering of Saccharomyces cerevisiae for the overproduction of short branched-chain fatty acids (2015)

Short branched-chain fatty acids (SBCFAs, C4-6) are versatile platform intermediates for the production of value-added products in the chemical industry. Currently, SBCFAs are mainly synthesized chemically, which can be costly and may cause environmental pollution. In order to develop an economical and environmentally friendly route for SBCFA production, we engineered Saccharomyces cerevisiae, a model eukaryotic microorganism of industrial significance, for the overproduction of SBCFAs. In particular, we employed a combinatorial metabolic engineering approach to optimize the native Ehrlich pathway in S. cerevisiae. First, chromosome-based combinatorial gene overexpression led to a 28.7-fold increase in the titer of SBCFAs. Second, deletion of key genes in competing pathways improved the production of SBCFAs to 387.4 mg/L, a 31.2-fold increase compared to the wild-type. Third, overexpression of the ATP-binding cassette (ABC) transporter PDR12 increased the secretion of SBCFAs. Taken together, we demonstrated that the combinatorial metabolic engineering approach used in this study effectively improved SBCFA biosynthesis in S. cerevisiae through the incorporation of a chromosome-based combinatorial gene overexpression strategy, elimination of genes in competitive pathways and overexpression of a native transporter. We envision that this strategy could also be applied to the production of other chemicals in S. cerevisiae and may be extended to other microbes for strain improvement.