gebhart/patrepeval huggingface dataset:
Calculation of sleeve-shaped filter elements made of the MR material (2014)

The article deals with the calculation of the characteristics of the thin-walled sleeve-type filter elements defined structural properties of the MR material. Existing results on the structural, filter, consumables and hydrodynamic characteristics of wire materials, the impact of their lifetime are fragmented and not linked to the calculation analytically closed form with the structural and technological parameters of the filter elements of the MR material. In the present paper we solve the problem of creating the calculation of the filter elements of the MR material with the specified filtering and hydrodynamic characteristics of the subject to the restrictions on the choice of dimensions and duration of use of the filter as a whole. The solutions of the fundamental problems to determine the structural and hydrodynamic characteristics of the MR material. The paper determines the possibility of creating a filter element, based on a given flow to ensure its performance and service life. We propose an algorithm for calculating the basic characteristics of the filter elements. It includes the solution of the system, and together with them the use of recommendations for selecting parameters of the structure and geometry of the MR material filter elements to ensure their desired filtering and hydrodynamic characteristics. This lets the rational parameters of the material structure with geometric MR material, filter and hydrodynamic characteristics of the filter elements. Such a generalized approach to the calculation of flow characteristics also provides an opportunity to take into account the life of the filter element. The use of the results is essential in the practice of creating high-performance filters based on thin-walled structures rational filter elements of bush type of woven wire MR material.
Suppl. Figure S13 from ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma (2023)

&lt;p&gt;S13: Immunohistochemical analysis of CyTof biomarker panel.&lt;/p&gt;
Functional and Structural Characterization of RsbU, a Stress Signaling Protein Phosphatase 2C (2004)

RsbU is a positive regulator of the activity of sigmaB, the general stress-response sigma factor of Gram+ microorganisms. The N-terminal domain of this protein has no significant sequence homology with proteins of known function, whereas the C-terminal domain is similar to the catalytic domains of PP2C-type phosphatases. The phosphatase activity of RsbU is stimulated greatly during the response to stress by associating with a kinase, RsbT. This association leads to the induction of sigmaB activity. Here we present data on the activation process and demonstrate in vivo that truncations in the N-terminal region of RsbU are deleterious for the activation of RsbU. This conclusion is supported by comparisons of the phosphatase activities of full-length and a truncated form of RsbU in vitro. Our determination of the crystal structure of the N-terminal domain of RsbU from Bacillus subtilis reveals structural similarities to the regulatory domains from ubiquitous protein phosphatases and a conserved domain of sigma-factors, illuminating the activation processes of phosphatases and the evolution of "partner switching." Finally, the molecular basis of kinase recruitment by the RsbU phosphatase is discussed by comparing RsbU sequences from bacteria that either possess or lack RsbT.
Visual programming languages from an object-oriented perspective (abstract) (1992)

Visual programming language research has evolved greatly since its early days. At first, attempts at visual programming mostly took the form of flowchart-like diagrams. But in recent years, a wide number of innovative approaches have been incorporated into visual languages, including object-oriented programming, form-based programming, programming by demonstration, and dataflow programming. Unfortunately, while many of these systems represent important ideas, only a few have been successful as complete visual programming languages. This tutorial explains why this is true, and describes ways in which the problem can be addressed.
Low Threshold Voltage Gate-First pMISFETs with Poly-Si/TiN/HfSiON Stacks Fabricated with PVD-based In-situ Solid Phase Interface Reaction (SPIR) Method (2007)

2007 International Conference on Solid State Devices and Materials,Low Threshold Voltage Gate-First pMISFETs with Poly-Si/TiN/HfSiON Stacks Fabricated with PVD-based In-situ Solid Phase Interface Reaction (SPIR) Method
Chemically Controlled Spatiotemporal Oscillations of Colloidal Assemblies (2017)

We report an autonomous oscillatory micromotor system in which active colloidal particles form clusters, the size of which changes periodically. The system consists of an aqueous suspension of silver orthophosphate microparticles under UV illumination, in the presence of varying concentrations of hydrogen peroxide. The colloid particles first attract each other to form clusters. After a short delay, these clusters abruptly disperse and oscillation begins, alternating between clustering and dispersion of particles. After a cluster oscillation initiates, the oscillatory wave propagates to nearby clusters and eventually all the clusters oscillate in phase-shifted synchrony. The oscillatory behavior is governed by an electrolytic self-diffusiophoretic mechanism which involves alternating electric fields generated by the competing reduction and oxidation of silver. The oscillation frequency is tuned by changing the concentration of hydrogen peroxide. The addition of inert silica particles to the system results in hierarchical sorting and packing of clusters. Densely packed Ag<sub>3</sub> PO<sub>4</sub> particles form a non-oscillating core with an oscillating shell composed largely of silica microparticles.
RETRACTED: Controlled Light Cross-Linking Technique to Prepare Healable Materials (2017)

Detection of defects, damages and cracks in structural polymers is very difficult, and even if they are detected, they will be very hard to be repaired. This is because different kinds of stress can reduce the mechanical efficiency of structural and functional thermosetting composite materials and they can damage the polymer matrix, thus reducing the purposed properties. General healing processes use thermal energy "alone" to heal these materials, thus impairing the intended properties of the materials. Therefore, we present a thermal healing ability that can be switched-on and/or -off at desire using illumination by photon energy (visible and ultra violet). By this technique, one can control local heal while keeping the efficiency of the material nearly unchanged. Furan-based cross-linker chemically reacts (forward- and reverse-reaction) with short-chains of maleimide-substituted poly(lauryl methacrylate) to form robust chemical bonds. This permits us to perform local control over thermally induced de- and/or re-cross-linking techniques. One can extend and apply this technique to cover micro-devices, coating-techniques, fine lithography, micro- and nano-fabrication processes, etc. Therefore, the present work developed a suitable technology with structural polymeric material, which has the ability to self-heal cracks (and damages) and recover structural function.
Neonatal Hypoglycaemia and Visual Development: A Review (2017)

The effect of NH on visual development is unclear. It is currently unknown whether NH affects visual function in mid-to-late childhood when many visual functions reach adult levels.
2-D Analytical Model of Heat and Moisture Diffusion in Bonded Single Lap Joints (2022)

Abstract A two-dimensional elastic analytical model for bonded single lap joints subjected to heat and moisture diffusion is presented. The distributions of peel and shear stress in the bond area are calculated. Local moisture concentration and bondline temperature determine the properties of the adhesive layer, which vary in the space and time coordinates. Adhesive diffusivity coefficient and absolute saturated concentration are affected by the material temperature, and scenarios of individual and combined heat and moisture diffusion are analyzed. The governing partial differential equations are solved numerically, and a simplified shear stress formulation is introduced for low-modulus adhesives. Two-dimensional gradients in the adhesive properties affect the peel and shear stress in the bondline. Diffusive patterns in the direction of the loading axis of the joint can contribute to a positive stress redistribution along the overlap, while the results of this study show that softening patterns in the transverse direction may severely impact the joint performance. In the initial stages of environmental exposure, significant increases in peak shear stress are observed in the innermost portions of the bond area. Less significant gradients are observed for the peel stress distribution, under the same conditions. A 3-D Finite Elements Analysis is used to compute adhesive peel and shear stresses, and the results are in reasonable agreement with the proposed analytical model.
Synthesis and properties of new Si—H‐containing polymers (1998)

Poly[(methylsilylene)ethynylene] (1) and poly[2,5-thiophenediyl(methylsilylene)] (2) are prepared in good yields. Thermogravimetric analysis and differential scanning calorimetry indicate the SiH group to increase the pyrolysis residue yields. Gelation was achieved from polymer 1 to get improved preceramic materials. © 1998 John Wiley & Sons, Inc. J. Polym. Sci. A Polym. Chem. 36: 2275–2282, 1998
Live Demonstration: Unobtrusive and Continuous Monitoring of Respiration Employing a Dual CW Radar Assembly (2020)

The present demonstration exhibits a standalone system for non-contact monitoring of a subject's respiration rate using a dual continuous wave radar (CW) radar setup. The monitoring system which includes a dual radar set-up, a preamplifier circuit, a Raspberry pi Board (RPi v3B+) for processing and interfacing tasks, and a screen for visual inspection of the respiration signal and rate. The algorithm running on the RPi board selects the optimum channel from the dual radar setup and displays the breathing rate.
Discovering selective antiferroptotic inhibitors of the 15LOX/PEBP1 complex noninterfering with biosynthesis of lipid mediators (2023)

Programmed ferroptotic death eliminates cells in all major organs and tissues with imbalanced redox metabolism due to overwhelming iron-catalyzed lipid peroxidation under insufficient control by thiols (Glutathione (GSH)). Ferroptosis has been associated with the pathogenesis of major chronic degenerative diseases and acute injuries of the brain, cardiovascular system, liver, kidneys, and other organs, and its manipulation offers a promising new strategy for anticancer therapy. This explains the high interest in designing new small-molecule-specific inhibitors against ferroptosis. Given the role of 15-lipoxygenase (15LOX) association with phosphatidylethanolamine (PE)-binding protein 1 (PEBP1) in initiating ferroptosis-specific peroxidation of polyunsaturated PE, we propose a strategy of discovering antiferroptotic agents as inhibitors of the 15LOX/PEBP1 catalytic complex rather than 15LOX alone. Here we designed, synthesized, and tested a customized library of 26 compounds using biochemical, molecular, and cell biology models along with redox lipidomic and computational analyses. We selected two lead compounds, FerroLOXIN-1 and 2, which effectively suppressed ferroptosis in vitro and in vivo without affecting the biosynthesis of pro-/anti-inflammatory lipid mediators in vivo. The effectiveness of these lead compounds is not due to radical scavenging or iron-chelation but results from their specific mechanisms of interaction with the 15LOX-2/PEBP1 complex, which either alters the binding pose of the substrate [eicosatetraenoyl-PE (ETE-PE)] in a nonproductive way or blocks the predominant oxygen channel thus preventing the catalysis of ETE-PE peroxidation. Our successful strategy may be adapted to the design of additional chemical libraries to reveal new ferroptosis-targeting therapeutic modalities.
Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device (2016)

Here, we describe a protocol to perform long-term co-culture of multi-species human gut microbiome with microengineered intestinal villi in a human gut-on-a-chip microphysiological device. We recapitulate the intestinal lumen-capillary tissue interface in a microfluidic device, where physiological mechanical deformations and fluid shear flow are constantly applied to mimic peristalsis. In the lumen microchannel, human intestinal epithelial Caco-2 cells are cultured to form a 'germ-free' villus epithelium and regenerate small intestinal villi. Pre-cultured microbial cells are inoculated into the lumen side to establish a host-microbe ecosystem. After microbial cells adhere to the apical surface of the villi, fluid flow and mechanical deformations are resumed to produce a steady-state microenvironment in which fresh culture medium is constantly supplied and unbound bacteria (as well as bacterial wastes) are continuously removed. After extended co-culture from days to weeks, multiple microcolonies are found to be randomly located between the villi, and both microbial and epithelial cells remain viable and functional for at least one week in culture. Our co-culture protocol can be adapted to provide a versatile platform for other host-microbiome ecosystems that can be found in various human organs, which may facilitate in vitro study of the role of human microbiome in orchestrating health and disease.
Cholestasis Induced by Parabolan Successfully Treated with the Molecular Adsorbent Recirculating System (2006)

We describe a case of a 21-year-old male bodybuilder who overdosed on Parabolan (trenbolone acetate) because of its anabolic activity. The patient, with no previous medical history, experienced pruritus and yellow discoloration of the skin and sclerae. Basic biochemical laboratory examination revealed signs of cholestasis with a serum bilirubin level of up to 65.5 mg/dl. Because supportive medical treatment was ineffective, the patient was treated with the molecular adsorbent recirculating system (MARS). Five MARS cycles lasting from 8 to 12 hours were performed every second day. The procedure was well tolerated by the patient and resulted in a sustained relief of pruritus. At the 2-month follow-up visit the plasma bilirubin level had decreased to 2 mg/dl.
Server Location Verification and Server Location Pinning: Augmenting TLS Authentication (2016)

We introduce the first known mechanism providing realtime server location verification. Its uses include enhancing server authentication (e.g., augmenting TLS) by enabling browsers to automatically interpret server location information. We describe the design of this new measurement-based technique, Server Location Verification (SLV), and evaluate it using PlanetLab. We explain how SLV is compatible with the increasing trends of geographically distributed content dissemination over the Internet, without causing any new interoperability conflicts. Additionally, we introduce the notion of (verifiable) "server location pinning" within TLS (conceptually similar to certificate pinning) to support SLV, and evaluate their combined impact using a server-authentication evaluation framework. The results affirm the addition of new security benefits to the existing SSL/TLS-based authentication mechanisms. We implement SLV through a location verification service, the simplest version of which requires no server-side changes. We also implement a simple browser extension that interacts seamlessly with the verification infrastructure to obtain realtime server location-verification results.
Micro‐community cytometry: sensing changes in cell health and glycoconjugate expression by imaging and flow cytometry (2013)

Discerning the extent of biologically relevant heterogeneity presents unique challenges to both microscopy and flow cytometry. Micro-environmental influences and stochastic changes in cellular behaviour can act to mask the origins of both progression and therapeutic resistance in tumour cell systems. In part the dimensionality of different and frequently metastable states can be assessed by multi-parameter flow cytometry with unparalleled statistical robustness. Complementary application of imaging can provide valuable insights into the complex temporal changes that can occur in cell micro-communities either spontaneously or in response to selection pressure. With an extensive range of methodologies for the labelling of cells there are multiple options for tracking cells, defining fate and the re-construction of provenance and behavioural history. The challenge is highlighted by attempts to identify the critical glycosylation events modifying the function of cell surface proteins. Central to a cytometric approach is the availability of methods that reveal cell health and are compatible with the detection of cell surface changes within dynamic micro-communities. The review briefly addresses the options for sensing cell health and the co-application of an antibody mimetic for detection of cell surface glycoconjugate expression accessible for both imaging and flow cytometry.
Preclinical and clinical testing of radiolabelled monoclonal antibodies for immunoscintigraphy. (1990)

Immunoscintigraphy is a new method for in vivo diagnosis of diseases using monoclonal antibodies. Emphasis is placed on diagnosis of malignant tumors although the range of application includes a number of non-malignant diseases. To date, no European country has issued clear guidelines on the testing and registration of those monoclonal antibodies labelled with a radionuclide and used for diagnostic. This involves the risk of overregulation which would considerably reduce the applicability of the method. This holds particularly true since the complications initially anticipated with the use of such compounds did not occur. The conduct of immunoscintigraphy has evolved during the last few years. For reasons of applicability, but also and mainly for reasons of radiation hygiene, I-131 and finally also In-111 were abandoned as labelling nuclides and replaced by Tc-99m. The protein amount involved was reduced. Some false estimations, which were due to particularities or artifacts of the iodinated antibodies used at the beginning, had to be corrected: the representation of the liver in a scintigram is part of the physiological distribution of antibodies; and fragments of antibodies normally do not present the anticipated kinetic advantages. The clinical results obtained with colon carcinomas show that not only recurrencies and metastases, but also primary tumors can be detected with equally high sensitivity. In contrast, radioimmunotherapy does not yet seem as successful, at least against solid tumors.
Voltage shift phenomena introduced by reverse-bias application in multilayer organic light emitting diodes (2000)

The effects of reverse-bias on the current–voltage (I–V) and luminance–voltage (L–V) properties of organic light-emitting diodes (OLEDs) were systematically measured. Shifts toward lower voltage both in I–V and L–V curves were observed for the OLEDs treated by reverse-bias application. The voltage-shift phenomena were discussed based on the effective drive voltage change induced by reverse bias application and the voltage-shift process was analyzed by using a relaxation model. Good consistency between experimental results and model calculations was obtained. It was found that the voltage shift process has several time constants. For example, three time constants (t01=17.9 s, t02=507 s, t03=7169 s) exist in the voltage shift process for ITO/TPD/Alq3/Mg:Ag diodes. The voltage shifts are assumed to be closely related to the movement of ionic impurities and rotations of permanent dipoles in organic layers.
Physiological and morphological changes in bovine mammary glands following intramammary infusion of recombinant interferon-gamma. (1992)

Eleven lactating dairy cows were used to evaluate the response of bovine mammary glands to increasing doses of recombinant bovine interferon (rBoIFN)-gamma. Right front and rear quarters were intramammarily infused with eight different doses (10(2) U to 2 x 10(8) U/quarter) of rBoIFN-gamma; each dose was tested in at least two quarters. Left udder halves served as within animal controls in which quarters were injected with a saline placebo or were not infused at all. Milk secretion samples for compositional analysis were collected from each quarter prior to infusion and at 6, 24, 36 and 48 h following infusion. Animals were slaughtered immediately following the 48 h sampling period and mammary tissue was obtained for morphometric analyses. Milk composition was similar between control quarters and those quarters infused with up to 10(5) U of rBo-IFN-gamma during the entire sampling period. Quarters infused with 10(6) U and 10(7) U of rBoIFN-gamma had higher milk somatic cell counts (SCC) following treatment compared with preinfusion values. Changes in the composition of mammary secretion were most dramatic in quarters infused with greater than or equal to 10(8) U of rBoIFN-gamma as indicated by the significant increase in SCC and milk pH with a concomitant decrease in lactose concentration when compared with pre-infusion values or with control quarters. Morphometric analysis of tissue demonstrated an increase in stroma, a decrease in luminal area, and a marked increase in the number of infiltrating leukocytes in those quarters infused with the higher doses of rBoIFN-gamma.(ABSTRACT TRUNCATED AT 250 WORDS)
On the capacity of multisource non-coherent network coding (2009)

We consider multisource non-coherent network coding, where multiple sources send information to one or multiple receivers. We prove that this is equivalent to a ldquosubspacerdquo channel, that takes subspaces as inputs and outputs. We then show that the rate of each individual receiver is upper bounded as delta <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">i</sub> (T - delta <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> - delta <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> ), where delta <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">i</sub> is what we define to be the ldquodominatingrdquo dimension in the subspace codebook of source i, and T is the ldquocoherencerdquo time of the network.
Measurement of the flavour composition of dijet events in pp collisions at $\sqrt{s}=7\ \mbox{TeV}$ with the ATLAS detector (2013)

This paper describes a measurement of the flavour composition of dijet events produced in pp collisions at s = 7 TeV using the ATLAS detector. The measurement uses the full 2010 data sample, corresponding to an integrated luminosity of 39 pb -1 . Six possible combinations of light, charm and bottom jets are identified in the dijet events, where the jet flavour is defined by the presence of bottom, charm or solely light flavour hadrons in the jet. Kinematic variables, based on the properties of displaced decay vertices and optimised for jet flavour identification, are used in a multidimensional template fit to measure the fractions of these dijet flavour states as functions of the leading jet transverse momentum in the range 40 GeV to 500 GeV and jet rapidity |y| < 2.1. The fit results agree with the predictions of leading-and next-to-leading-order calculations, with the exception of the dijet fraction composed of bottom and light flavour jets, which is underestimated by all models at large transverse jet momenta. The ability to identify jets containing two b-hadrons, originating from e.g. gluon splitting, is demonstrated. The difference between bottom jet production rates in leading and subleading jets is consistent with the next-to-leading-order predictions.
Olive oil and its main phenolic micronutrient (oleuropein) prevent inflammation-induced bone loss in the ovariectomised rat (2004)

International audience