gebhart/patrepeval huggingface dataset:
Supplementary Data from α<sub>v</sub>β<sub>3</sub> Integrin Mediates Radioresistance of Prostate Cancer Cells through Regulation of Survivin (2023)

&lt;p&gt;SF legend&lt;/p&gt;
Impact of Casimir force on nano accelerometers modeling (2006)

In this article we compute the Casimir force for silicon nanostructures considering conductivity of silicon and material thickness as both most important parameters for NEMS modeling. We quantify the strong impact of this force on the static and dynamic behavior of a nano accelerometer and compare results to classical computations.
DIGITAL TEMPLATING IN TOTAL HIP ARTHROPLASTY IN THE NHS: ‘COMPUTER SAYS NO…’ (2011)

Introduction: Preoperative planning plays an important role in any surgical procedure and total hip replacement (THR) is no exception. Templating of radiographs allows preoperative assessment of the correct size of implant to be used, lowers the risk of periprosthetic fracture, helps restore femoral offset and leg length, facilitates the optimisation of alignment and ensures the correct implants sizes are available. With the wide scale use of Picture Archiving and Communication Systems (PACS) in the National Health Service (NHS), the potential exists for faster and more accurate templating of THRs. Aim: In performing this study, we assessed whether there is adequate provision of the current NHS PACS to allow optimal digital templating for THRs. We also made comparison between the availability and overall ease of conventional versus digital templating. Methods: Data was collected using a telephone questionnaire requesting information from the on-call orthopaedic Specialist Registrar (SpR) in 28 Greater London and surrounding area NHS Hospitals. Data on the availability of PACS and the ability to template using hard-copy or digital templating was collected and analysed. Results: PACS were used in all 28 (100%) hospitals that were contacted. None performed conventional templating regularly and only 8 (28.6%) admitted to occasional templating. The predominant reason for this was difficulty in obtaining hard copies of x-rays in 12 (42.9%) hospitals, as well as lack of availability acetate templates, with 13 (46.4%) claiming that this was the case. Digital templating software was available in 14 (50%) hospitals. Despite this, none of them performed digital templating regularly. In the 50% that did have digital templating, this was not routinely done for the following reasons: only 3 (10.7%) allowed easy access to the software to the SpRs only one SpR received formal training on how to use the system only one hospital regularly used Methods: to accurately allow the software to assess magnification for accurate sizing (e.g. sizing balls) Discussion: Digital PACS systems have made great improvement in the access of radiographs in the NHS. With regards to orthopaedic practice, however, we have shown that the benefit of digital templating is being overlooked within the NHS.
Electron diffraction, X-ray powder diffraction and pair-distribution-function analyses to determine the crystal structures of Pigment Yellow 213, C23H21N5O9 (2009)

The crystal structure of the nanocrystalline alpha phase of Pigment Yellow 213 (P.Y. 213) was solved by a combination of single-crystal electron diffraction and X-ray powder diffraction, despite the poor crystallinity of the material. The molecules form an efficient dense packing, which explains the observed insolubility and weather fastness of the pigment. The pair-distribution function (PDF) of the alpha phase is consistent with the determined crystal structure. The beta phase of P.Y. 213 shows even lower crystal quality, so extracting any structural information directly from the diffraction data is not possible. PDF analysis indicates the beta phase to have a columnar structure with a similar local structure as the alpha phase and a domain size in column direction of approximately 4 nm.
Endogenous Two-Photon Excited Fluorescence Imaging Characterizes Neuron and Astrocyte Metabolic Responses to Manganese Toxicity (2017)

As neurodegenerative conditions are increasingly linked to mitochondrial dysfunction, methods for studying brain cell metabolism at high spatial resolution are needed to elucidate neurodegeneration mechanisms. Two-photon excited fluorescence (TPEF) imaging is a non-destructive, high-resolution technique for studying cell metabolism via endogenous fluorescence of reduced nicotinamide adenine dinucleotide (phosphate) (NAD(P)H) and flavin adenine dinucleotide (FAD). We employed TPEF to study the metabolism of primary rat astrocyte and neuronal cultures under normal growth conditions and in response to manganese (Mn) treatment. Histograms of pixel-wise optical redox ratio, defined as FAD/(FAD + NAD(P)H), revealed three distinct redox distributions and significant differences in their relative weights between astrocytes and neurons. When treated with Mn, both cell types exhibited redox ratio shifts consistent with increased oxidative stress. However, the manner in which the redox distributions was affected was distinct for the two cell types. Furthermore, NAD(P)H fluorescence lifetime imaging revealed an increase in bound NAD(P)H fraction upon Mn treatment for neurons, consistent with enhanced apoptosis. Astrocytes showed a decrease in bound fraction, possibly due to a shift towards glycolytic metabolism in response to impaired respiration. These results exhibit TPEF's utility for characterizing detailed metabolic changes of different brain cell types in response to neurotoxins.
Secretory leukocyte protease inhibitor (SLPI) as a potential target for inhibiting metastasis of triple-negative breast cancers (2017)

SLPI has been implicated in the progression and metastasis of certain cancers. However, the effects of SLPI seem to be tumor-specific and the mechanisms remain poorly defined. Here, we demonstrate that highly metastatic, triple-negative breast cancer (TNBC) 4T1 cells secreted more SLPI compared to their non-metastatic counterparts. Furthermore, SLPI secretion directly correlated with spontaneous lung metastasis from 4T1 tumors orthotopically implanted in mice. Consistent with our experimental results, we also found that higher SLPI expression levels correlate with worse clinical outcome in basal/TNBC patients. Using high-throughput screening we identified a novel compound, C74, which significantly inhibits SLPI secretion. C74 administration in our mouse model slows the growth of primary 4T1 tumors and inhibits their dissemination to the lung. We also discovered that SLPI physically interacts with the retinoblastoma tumor suppressor protein (Rb) and releases FoxM1 from the Rb-FoxM1 complex, which may activate FoxM1 target genes involved in breast cancer metastasis.
Abstract LB-257: Immunoadjuvant ISG15 enhances human papillomavirus 16 antigen-specific cell-mediated antitumor immunity (2014)

Abstract Adjuvants are critical components of most clinically used vaccines and act as substances to enhance adaptive immune responses to an antigen. Here we examine a new immunoadjuvant, interferon stimulated gene 15 (ISG15), for its adjuvant effects in an HPV-associated cancer immune therapy model where cell-mediated immunity is crucial for protection. ISG15 is an ubiquitin-like protein induced by type I interferon and associated with antiviral activity. Recent studies of ISG15 have re-established that ISG15 is also a secreted molecule with cytokine-like properties. However, the potential ability of ISG15 to influence the Th1 and CD8 T cell immune responses and act a vaccine adjuvant, has not been well defined. To this end, we developed a highly optimized DNA-vector encoding the ISG15 protein and evaluated its immunogenicity to increase the cellular immune responses in combination with a DNA consensus-based fusion HPV16 E6/E7 construct. We demonstrate that ISG15 can enhance Ag-specific Th1 memory responses to HPV16 E6/E7 antigen by IFN-γ ELISpot analysis. Moreover, ISG15 elicited strong HPV16 Ag-specific polyfunctional CD8+ T cells that secrete both anti-viral IFN-γ and/or TNF-α cytokines. Vaccination conferred remarkable 100% protection against challenge with HPV E6 and E7-expressing tumors. Overall, these findings lay the groundwork of ISG15 as a new immunoadjuvant candidate in the context of cancer immunotherapy. Citation Format: Daniel Villarreal, Megan C. Wise, Jian Yang, David B. Weiner. Immunoadjuvant ISG15 enhances human papillomavirus 16 antigen-specific cell-mediated antitumor immunity. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr LB-257. doi:10.1158/1538-7445.AM2014-LB-257
Tau positron emission tomography, cerebrospinal fluid and plasma biomarkers of neurodegeneration, and neurocognitive testing: an exploratory study of participants with myotonic dystrophy type 1 (2022)

Abstract Objective To investigate Tau pathology using multimodal biomarkers of neurodegeneration and neurocognition in participants with myotonic dystrophy type 1 (DM1). Methods We recruited twelve participants with DM1 and, for comparison, two participants with Alzheimer’s Disease (AD). Participants underwent cognitive screening and social cognition testing using the Dépistage Cognitif de Québec (DCQ), among other tests. Biomarkers included Tau PET with [18F]-AV-1451, CSF (Aβ, Tau, phospho-Tau), and plasma (Aβ, Tau, Nf-L, GFAP) studies. Results Of the twelve DM1 participants, seven completed the full protocol (Neurocognition 11/12; PET 7/12, CSF 9/12, plasma 12/12). Three DM1 participants were cognitively impaired (CI). On average, CI DM1 participants had lower scores on the DCQ compared to cognitively unimpaired (CU) DM1 participants (75.5/100 vs. 91.4/100) and were older (54 vs. 44 years old) but did not differ in years of education (11.3 vs. 11.1). The majority (6/7) of DM1 participants had no appreciable PET signal. Only one of the CI participants presented with elevated Tau PET SUVR in bilateral medial temporal lobes. This participant was the eldest and most cognitively impaired, and had the lowest CSF Aβ 1-42 and the highest CSF Tau levels, all suggestive of co-existing AD. CSF Tau and phospho-Tau levels were higher in the 3 CI compared to CU DM1 participants, but with a mean value lower than that typically observed in AD. Nf-L and GFAP were elevated in most DM1 participants (9/11 and 8/11, respectively). Finally, CSF phospho-Tau was significantly correlated with plasma Nf-L concentrations. Conclusions and relevance We observed heterogenous cognitive and biomarker profiles in individuals with DM1. While some participants presented with abnormal PET and/or CSF Tau, these patterns were highly variable and only present in a small subset. Although DM1 may indeed represent a non-AD Tauopathy, the Tau-PET tracer used in this study was unable to detect an in vivo Tau DM1 signature in this small cohort. Interestingly, most DM1 participants presented with elevated plasma Nf-L and GFAP levels, suggestive of other, possibly related, central brain alterations which motivate further research. This pioneering study provides novel insights towards the potential relationship between biomarkers and neurocognitive deficits commonly seen in DM1.
NOVEL DETECTION AND PREDICTION TOOL FOR BEARING DAMAGES ON HEAVY HAUL VEHICLES USING WAY-SIDE DETECTORS (2020)

Incipient bearing damages on heavy haul vehicles can lead to detrimental disruptions in heavy haul operation and even to derailment of trains. The consequences are damage of the railway infrastruct ...
Crystallization Mechanism of Cage-Based, Small-Pore Molecular Sieves: A Case Study of CHA and LEV Structures (2017)

Here we have investigated the crystallization mechanisms of SSZ-13 and SAPO-34 with the CHA topology and NU-3 and SAPO-35 with the LEV topology using 1H–13C CP MAS NMR and IR spectroscopies. The nucleation of these cage-based, small-pore molecular sieves begins with the formation of large 20-hedral cha or 17-hedral lev cages, with incorporation of organic structure-directing agents (SDAs) alone or together with inorganic cations, in both aluminosilicate and silicoaluminophosphate compositions. The next two steps are the construction of multiple-cha or multiple-lev cages in an appropriate arrangement by sharing 8-rings and their subsequent coupling to form smaller 8-hedral double 6-ring units, leading to viable nuclei of CHA or LEV molecular sieves. The initial formation of the large cages, especially in the presence of large SDA molecules, can in our view be generalized to other cage-based zeolite systems.
Turning theory to practice in model-based FDI: Successful application to new generation Airbus aircraft (2017)

International audience
Secure Biometrics Via Syndromes (2005)

We consider the secure biometric storage problem and develop a solution using syndrome codes. Specifically, biometrics such as fingerprints, irises, and faces are often used for authentication, access control, and encryption instead of passwords. While it is well known that passwords should never be stored in the clear, current systems often store biometrics in the clear and are easily compromised. We describe the secure biometric storage problem by discussing the insecurities in current systems, the reasons why password hashing/encryption algorithms are unsuitable for biometrics, and propose a secure biometric storage framework based on syndrome codes and the Slepian-Wolf theorem. 1
Vertical enhancement-mode InP MISFET's fabricated on n-type substrate (1986)

We report a new vertical structure InP enhancement-mode MISFET. These transistors are made on an Fe-doped semi-insulating InP epitaxial layer grown by organometallic vapor-phase epitaxy (OMVPE) on an n-type InP substrate. Thermally evaporated borosilicate is used as the gate insulator. Transconductances as high as 100 mS/mm have been achieved with a gate length of approximately 2.8µm. The novelty and potential advantages of the vertical structure are discussed.
Proliferation is a requirement for differentiation of oligodendrocyte progenitor cells during CNS remyelination (2020)

Summary Oligodendrocytes that generate new myelin sheaths around demyelinated axons in the regenerative process of remyelination are generally derived from oligodendrocyte progenitor cells (OPCs). During this process, OPCs become activated, populate the area of myelin loss, and finally differentiate. Although much is known about the individual stages of remyelination, the exact sequence of events and whether a dependency of each individual stage on each other exists is unknown. Understanding the biology behind these questions is important for the development of remyelination therapies to overcome the age-related decline in remyelination efficiency observed in the chronic phase of multiple sclerosis (MS). Here we show that, following toxin-induced demyelination, all re-populating OPCs first migrate into the site of damage, undergo relatively few rounds of division and eventually differentiate. We further show that OPC proliferation is a requirement for differentiation. Together, our results reveal an unexpected link between OPC proliferation and differentiation, and opens up the possibility of novel regenerative strategies in MS focussing on stimulating OPC proliferation.
Supplemental Figure Legends from CXCL12γ Promotes Metastatic Castration-Resistant Prostate Cancer by Inducing Cancer Stem Cell and Neuroendocrine Phenotypes (2023)

&lt;p&gt;Figure Legends&lt;/p&gt;
A pulsatile flow phantom for image-guided high-intensity focused ultrasound studies on blood vessels (2005)

A pulsatile flow phantom has been developed for controlled studies of acoustic hemostasis and high intensity focused ultrasound (HIFU) effects on blood vessels. The flow phantom consists of an excised carotid artery attached to a pulsatile pump and embedded in an optically and acoustically transparent gel to create an ex vivo model of a human artery. The artery was punctured with a needle to simulate percutaneous vascular injury. A HIFU transducer with a focal distance of 6 cm and a frequency of 3.33 MHz was used to treat the puncture. B-mode and power-Doppler ultrasound were used to locate the site of the puncture, target the HIFU focus, and monitor treatment. Also, the effects of vascular flow on HIFU lesions were studied by treating vessels in the phantom for different times at a variety of flows. In both studies, histology was done on the artery. In nine trials, HIFU was able to provide complete hemostasis in 55 ± 31 s. It is feasible to use the flow phantom to study acoustic hemostasis of blood vessels. Histology shows that the flow in the phantom appears to diminish the vascular damage from HIFU.
CNN-based multi-class multi-label classification of sound scenes in the context of wind turbine sound emission measurements (2021)

Within the scope of the interdisciplinary project WEA-Akzeptanz, measurements of the sound emission of wind turbines were carried out at the Leibniz University Hannover. Due to the environment there are interfering components (e. g. traffic, birdsong, wind, rain, ...) in the recorded signals. Depending on the subsequent signal processing and analysis, it may be necessary to identify sections with the raw sound of a wind turbine, recordings with the purest possible background noise or even a specific combination of interfering noises. Due to the amount of data, a manual classification of the audio signals is usually not feasible and an automated classification becomes necessary. In this paper, we extend our previously proposed multi-class single-label classification model to a multi-class multi-label model, which reflects the real-world acoustic conditions around wind turbines more accurately and allows for finer-grained evaluations. We first provide a short overview of the data acquisition and the dataset. We then briefly summarize our previous approach, extend it to a multi-class multi-label formulation, and analyze the trained convolutional neural network regarding different metrics. All in all, the model delivers very reliable classification results with an overall example-based F1-score of about 80 % for a multi-label classification of 12 classes.
Religiosity is a protective factor against self-injurious thoughts and behaviors in Jewish adolescents: Findings from a nationally representative survey (2014)

This is the first study demonstrating religiosity to have a direct independent protective effect against self-injurious thoughts and behaviors in Jewish adolescents. This finding has clinical implications regarding risk assessment and suicide prevention. Further research can potentially elucidate the complex relationship between religiosity, self-injury and suicide in this population.
Antitumor activity of a novel, human anti-epidermal growth factor receptor (EGFR) monoclonal antibody (IMC-11F8) in human tumor xenograft models (2004)

5353 Molecular inhibition of epidermal growth factor receptor (EGFR) function is a promising approach to cancer therapy. In this report, we describe the in vivo activity of a novel, high affinity human anti-EGFR monoclonal antibody, designated IMC-11F8. Antitumor activity of IMC-11F8 was evaluated in models of established (0.20 cm3) epidermoid (A431), pancreatic (BxPC-3) or colon (HT-29 and DLD-1) human tumor xenografts in athymic mice. Dose-dependent inhibition of tumor growth in all models was observed in mice treated with IMC-11F8 (1mg or 0.3mg; 3x/week) with T/C values ranged from 3% to 17% for the 1mg dose and from 38% to 81% for the 0.3mg dose. Histological examination of tumor xenografts demonstrated a significant decrease in the neoplastic cell compartment compared to controls. Combination therapy experiments were performed in colon xenograft models where established DLD-1, GEO, or HT-29 tumors were treated with IMC-11F8, irinotecan (100mg/kg; q7dx5), or the combination. Treatment with combination therapy significantly inhibited the growth of these tumors compared to IMC-11F8 or CPT-11 therapy alone. Combination therapy with the high dose of IMC-11F8 and CPT-11 resulted in synergistic anti-tumor effect in all three tumor models with T/C% values of 8%, 3%, and 10% for DLD-1, GEO and HT-29, respectively. Combination therapy produced tumor regressions in 50% of the DLD-1 and HT-29 animals and in 90% of the GEO tumors. Histological examination of residual tumors after combination treatment showed an increase in pyknotic nuclei and a decrease in mitotic figures; this resulted in a substantial decrease in viable tumor compartment with near elimination of neoplastic cells. The present study shows that IMC-11F8 may be an effective therapy in the treatment of EGFR-positive tumors and warrants clinical evaluation of this agent.
Azeotrope enabled polymerization of ethylene oxide (2016)

We report a synthetic route for poly(ethylene oxide) (PEO) using azeotropic distillation to remove water and drive the equilibrium of an alkyl hydroxide and potassium hydroxide to potassium alkoxide, avoiding the use of pyrophoric organometallics.
Comparative Therapy Evaluation of Intravitreal Bevacizumab and Triamcinolone Acetonide on Persistent Diffuse Diabetic Macular Edema (2008)

Purpose To compare the effect of an intravitreal injection of bevacizumab, an anti-vascular endothelial growth factor (VEGF) antibody, with that of triamcinolone acetonide, a corticosteroid for reduction of diabetic macular edema (DME). Design Prospective, comparative interventional case series. Methods Twenty-eight eyes of 14 patients with bilateral DME participated in this study. In each patient, one eye received an intravitreal injection of 4 mg triamcinolone acetonide and the other eye received 1.25 mg bevacizumab. The clinical course of best-corrected visual acuity (VA) with a logarithm of the minimum angle of resolution chart and averaged foveal thickness using optical coherence tomography was monitored for up to 24 weeks after the injection. Results Before the injection, foveal thickness and VA were 522.3 ± 91.3 μm and 0.64 ± 0.28 μm in the triamcinolone-injected eye, and 527.6 ± 78.8 μm and 0.61 ± 0.18 μm in the bevacizumab-injected eye, respectively; there was no significant difference between the eyes. One week after the injection, both eyes showed significant regression of macular edema. The triamcinolone-injected eye (342.6 ± 85.5 μm and 0.33 ± 0.21 μm) showed significantly better results than the bevacizumab-injected eye (397.6 ± 103.0 μm and 0.37 ± 0.17 μm). However, both eyes showed the recurrence of macular edema with time, even at 24 weeks. Triamcinolone (410.4 ± 82.4 μm and 0.47 ± 0.25 μm) kept better results than bevacizumab (501.6 ± 92.5 μm and 0.61 ± 0.17 μm). Conclusions With the generally used concentration, intravitreal injection of triamcinolone acetonide showed better results in reducing DME and in the improvement of VA than that of bevacizumab, suggesting that the pathogenesis of DME is not only attributable to VEGF-dependency, but is also attributable to other mechanisms suppressed by corticosteroid.
Rehabilitation and Medical Management of the Adult with Spina Bifida (2008)

.As the life expectancy of individuals with spina bifida increases, a lifelong need for management of many health issues in a rehabilitation setting has emerged in recent years. Physiatrists, in consultation with a variety of adult specialists, are particularly well suited to manage the common musculoskeletal, skin, bowel, bladder, renal, neurological, and other issues that arise in the adult population. This article reviews the last 20 yrs of literature pertinent to the rehabilitative care of this population, summarizes current evidence-based practice, and identifies key areas in which scientific evidence is lacking and future research is needed.
Figure S8 from A Phase II Trial of Guadecitabine plus Atezolizumab in Metastatic Urothelial Carcinoma Progressing after Initial Immune Checkpoint Inhibitor Therapy (2023)

&lt;p&gt;Supplementary Figure 8: PD-L1 levels in tumor or tumor microenvironment does not associate with tumor progression or control.&lt;/p&gt;