gebhart/patrepeval huggingface dataset:
Reversible switching of the first hyperpolarisability of an NLO-active donor–acceptor molecule based on redox interconversion of the octamethylferrocene donor unit (2001)

Compound 1, containing an octamethylferrocene donor linked to a nitrothiophene acceptor via an ethenyl linker, shows a static first hyperpolarisability β0 of 95(±10) × 10−30 esu, which is reduced to 10(±2) × 10−30 esu on oxidation of the octamethylferrocene unit; this provides for a simple redox-based switching of the NLO characteristics of the compound.
(Invited) Non-Volatile Resistive Memory: Technology Capable of Revolutionary Compromises (2016)

Non-Volatile Resistive Memory (NVRM) such as Phase-Change Memory, Oxide-based Memory and Conductive Bridging Memory has rapidly increased in maturity in the last decade. In a memory market context dominated by DRAM and Flash technologies, the evolving memory hierarchy and the strong differentiation of the applications portfolio represent a real opportunity for NVRM to emerge. The real revolution of this technology resides in its versatility made possible by general trade-offs existing between the different NVRM performances, highlighted in the last years by the research and the development in several fields (e.g. materials science, engineering, etc.). We present here some of these trade-offs, and how they can be used to target specific applications.
Converging theories on dreaming: Between Freud, predictive processing, and psychedelic research (2023)

Dreams are still an enigma of human cognition, studied extensively in psychoanalysis and neuroscience. According to the Freudian dream theory and Solms' modifications of the unconscious derived from it, the fundamental task of meeting our emotional needs is guided by the principle of homeostasis. Our innate value system generates conscious feelings of pleasure and unpleasure, resulting in the behavior of approaching or withdrawing from the world of objects. Based on these experiences, a hierarchical generative model of predictions (<i>priors</i>) about the world is constantly created and modified, with the aim to optimize the meeting of our needs by reducing prediction error, as described in the <i>predictive processing</i> model of cognition. Growing evidence from neuroimaging supports this theory. The same hierarchical functioning of the brain is in place during sleep and dreaming, with some important modifications like a lack of sensual and motor perception and action. Another characteristic of dreaming is the predominance of <i>primary process thinking</i>, an associative, non-rational cognitive style, which can be found in similar altered states of consciousness like the effect of psychedelics. Mental events that do not successfully fulfill an emotional need will cause a prediction error, leading to conscious attention and adaptation of the priors that incorrectly predicted the event. However, this is not the case for <i>repressed priors</i> (RPs), which are defined by the inability to become reconsolidated or removed, despite ongoing error signal production. We hypothesize that Solms' RPs correspond with the <i>conflictual complexes</i>, as described by Moser in his dream formation theory. Thus, in dreams and dream-like states, these unconscious RPs might become accessible in symbolic and non-declarative forms that the subject is able to <i>feel</i> and make sense of. Finally, we present the similarities between dreaming and the psychedelic state. Insights from psychedelic research could be used to inform dream research and related therapeutic interventions, and vice versa. We propose further empirical research questions and methods and finally present our ongoing trial "Biological Functions of Dreaming" to test the hypothesis that dreaming predicts intact sleep architecture and memory consolidation, <i>via</i> a lesion model with stroke patients who lost the ability to dream.
Toward Single Molecule Detection with Photonic Crystal Microcavity Biosensors (2006)

Time resolved biomolecular binding events were measured using photonic crystal microcavity resonators integrated with microfluidics. The optical field is confined to a volume of 33 /spl times/ 10/sup -18/ liters, which enables monitoring of single binding events.
Temperature-Sensitive Mutants of Mycoplasma pneumotuae. II. Response of Hamsters (1971)

For development of an attenuated live vaccine strain of Mycoplasma pneumoniae, temperature-sensitive (ts) mutants were produced by treatment of the PI 1428 strain with N-methyl-N′-nitro-nitrosoguanidine. Eight of the nine mutants studied infected the hamster's respiratory tract, but these mutants were recovered significantly less often than wild-type organisms which were studied for comparative purposes. The ts mutants as a group were attenuated since they produced virtually no pneumonia, whereas wild-type organisms produced pneumonia in 50%–65% of inoculated animals. The ts mutants did not revert to wild type in vivo during a six-week period of observation. Infection with the mutants induced significant resistance to subsequent challenge with wild-type organisms. These findings offer some hope for eventual control of illness due to M. pneumoniae with a live vaccine.
Bee-gent: bonding and encapsulation enhancement agent framework for development of distributed systems (2000)

With the recent fast expansion of networks, interconnection of heterogeneous systems via networks is drawing increasing attention. In this context, the authors propose the Bee-gent (Bonding and Encapsulation Enhancement aGENT) agent framework, whose objective is to allow flexible interconnection between legacy systems, databases, and other existing systems by providing coordination and communication functions for distributed system components. With the proposed network, interaction protocols describing interactions between system components are divided between global processing related to problem solving, and component-specific local processing. Coordination between system components in the global processing is ensured through consistent control by mobile mediation agents. This facilitates design and maintenance if the system is modified or extended. In the paper the practical implementation of the proposed system is discussed and specific practical examples are presented to demonstrate the effectiveness of the system. © 2000 Scripta Technica, Syst Comp Jpn, 31(13): 42–56, 2000
Fluorinated triphenylphosphonium analogs improve cell selectivity and in vivo detection of mito-metformin (2022)

Triphenylphosphonium (TPP<sup>+</sup>) conjugated compounds selectively target cancer cells by exploiting their hyperpolarized mitochondrial membrane potential. To date, studies have focused on modifying either the linker or the cargo of TPP<sup>+</sup>-conjugated compounds. Here, we investigated the biological effects of direct modification to TPP<sup>+</sup> to improve the efficacy and detection of mito-metformin (MMe), a TPP<sup>+</sup>-conjugated probe we have shown to have promising preclinical efficacy against solid cancer cells. We designed, synthesized, and tested trifluoromethyl and methoxy MMe analogs (<i>p</i>CF<sub>3</sub>-MMe, <i>m</i>CF<sub>3</sub>-MMe, and <i>p</i>MeO-MMe) against multiple distinct human cancer cells. <i>p</i>CF<sub>3</sub>-MMe showed enhanced selectivity toward cancer cells compared to MMe, while retaining the same signaling mechanism. Importantly, <i>p</i>CF<sub>3</sub>-MMe allowed quantitative monitoring of cellular accumulation via <sup>19</sup>F-NMR <i>in vitro</i> and <i>in vivo</i>. Furthermore, adding trifluoromethyl groups to TPP<sup>+</sup> reduced toxicity <i>in vivo</i> while retaining anti-tumor efficacy, opening an avenue to de-risk these next-generation TPP<sup>+</sup>-conjugated compounds.
Low-energy high-flux ion bombardment-induced interfacial mixing during Al2O3 plasma-enhanced atomic layer deposition (2020)

We investigated the formation mechanism of interfacially mixed AlSiOx films on Si surfaces under low-energy (&amp;lt;15 eV), high-flux (&amp;gt;4 × 1015 cm−2 s−1) O2+ ion bombardment during Al2O3 plasma-enhanced atomic layer deposition. When high-dose O2+ ions (&amp;gt;1 × 1017 cm−2 cycle−1) were incident on the growing film surface during the oxidation steps in Al2O3 atomic layer deposition (ALD), interfacially mixed films with thin (∼0.8 nm) SiOx interlayers were formed on Si surfaces. The deposited films possessed a layered structure of Al2O3/AlSiOx/AlOx layers. In order to reveal the formation mechanism, films deposited during the early stages of ALD were evaluated using an angle-resolved x-ray photoelectron spectroscope. In the first oxidation step, thin, low-density SiOx films with weak Si–O bonds containing excess oxygen were formed on the Si surface. In subsequent oxidation steps, adsorbed Al atoms on the surface were knocked on by the energetic ions and penetrated into the SiOx film. As a result, Al atoms were taken into SiOx. Some of the Al atoms accumulated near the interface. After several tens of cycles, ordinary Al2O3 films were deposited on the Si-rich layers. Thus, the films with a layered structure of Al2O3/AlSiOx/AlOx layers were formed on the Si substrate.
ΕΛΕΥΘΕΡΕΣ ΡΙΖΕΣ: ΟΡΙΣΜΟΣ ΚΑΙ ΧΗΜΙΚΕΣ ΙΔΙΟΤΗΤΕΣ (2015)

Eλeύθeρeς ρίζeς:Βιοχημeία και Παθολογική Βιοχημeία [ΠΑΝEΠΙΣΤΗΜΙΟ ΙΩΑΝΝΙΝΩΝ, ΣΧΟΛΗ EΠΙΣΤΗΜΩΝ ΥΓEΙΑΣ, ΤΜΗΜΑ ΙΑΤΡΙΚΗΣ]
87 W, narrow-linewidth, linearly-polarized 1178 nm photonic bandgap fiber amplifier (2015)

High-power narrow-linewidth photonic bandgap fiber amplifier was demonstrated. In order to suppress stimulated Brillouin scattering, the seed linewidth was broadened by applying a random phase noise with an electro-optical modulator. A factor of 15 in terms of Brillouin gain suppression can be theoretically expected. An 87 W linearly-polarized (11 dB PER) and narrow-linewidth (780 MHz FWHM) output was obtained.
Coronary artery bypass surgery versus coronary stenting: risk-adjusted survival rates in 5,619 patients. (2002)

We used the Texas Heart Institute Cardiovascular Research Database to retrospectively identify patients who had undergone their 1st revascularization procedure with coronary artery bypass surgery (CABG; n=2,826) or coronary stenting (n=2,793) between January 1995 and December 1999. Patients were classified into 8 anatomic groups according to the number of diseased vessels and presence or absence of proximal left anterior descending coronary artery disease. Mortality rates were adjusted with proportional hazards methods to correct for baseline differences in severity of disease and comorbidity. We found that in-hospital mortality was significantly greater in patients undergoing CABG than in those undergoing stenting (3.6% vs 0.75%; adjusted OR 8.4; P < 0.0001). At a mean 2.5-year follow-up, risk-adjusted survival was equivalent (CABG 91%, stenting 95%; adjusted OR 1.26; P = 0.06). When subgroups matched for severity of disease were compared, no differences in risk-adjusted survival were seen. A survival advantage of stenting was noted in 3 categories of patients: those >65 years of age (OR 1.33, P = 0.049), those with non-insulin-requiring diabetes (OR 2.06, P = 0.002), and those with any noncoronary vascular disease (OR 1.59, P = 0.009). In this nonrandomized observational study, CABG had a higher periprocedural mortality rate than did percutaneous stenting. At 2.5 years, however, the survival advantage of stenting was no longer evident. These data suggest that there is no intermediate-term survival advantage of CABG over stenting in patients who have multivessel disease with lesions that can be treated percutaneously.
Advanced Ethanol Production with Acetic Acid Fermentation from Lignocellulosics (2019)

A novel process of bioethanol production from lignocellulosics was developed by acetic acid fermentation followed by hydrogenolysis of acetic acid to ethanol. This process includes a two-step hot-compressed water treatment of lignocellulosics to C6 and C5 sugars, decomposed products and lignin-derived compounds. In the subsequent fermentation, most of these products are to be anaerobically fermented into acetic acid in form of sodium acetate by free and/or immobilized co-culturing system (Clostridium thermocellum and C. thermoaceticum) by batch or fed-batch fermenter with pH controlled by NaOH or Ca(OH)2 to be 6.5-7.0. The obtained acetate aqueous solution was then converted and concentrated into acetic acid up to 200 g/L by bipolar membrane electrodialysis. The acetic acid was then converted to bioethanol without emitting CO2 via hydrogenolysis with Lewis acid-supported catalyst (Ru–Sn/TiO2). To evaluate a potential of this process, it was compared with the conventional alcoholic fermentation process, and found that, although conventional process can produce only 200-300 L bioethanol from one dried ton of Japanese cedar, this process can produce double in amount. In addition, energy recovery is higher than the conventional process, with CO2 emission unit (kg/GJ) being lower. Consequently, this process can be promising to reduce CO2 so as to mitigate environmental loading.
Fast-scanning, dispersion-adjustable reference delay for OCT using fiber Bragg gratings. (2003)

We report on the use of two matched linearly chirped fiber Bragg grating (FBG) in the reference arm of a Michelson interferometer as a means to achieve variable optical delay. We demonstrate that the properties of a linearly chirped FBG can be exploited to achieve millimeters of optical delay with physical stretches of the FBG on the order of tens of microns; this allows for optical delay line configurations that are easily driven by piezo-electric actuators.
Sequestration of a β‐Hairpin for Control of α‐Synuclein Aggregation (2014)

The misfolding and aggregation of the protein α-synuclein (α-syn), which results in the formation of amyloid fibrils, is involved in the pathogenesis of Parkinson's disease and other synucleinopathies. The emergence of amyloid toxicity is associated with the formation of partially folded aggregation intermediates. Here, we engineered a class of binding proteins termed β-wrapins (β-wrap proteins) with affinity for α-synuclein (α-syn). The NMR structure of an α-syn:β-wrapin complex reveals a β-hairpin of α-syn comprising the sequence region α-syn(37-54). The β-wrapin inhibits α-syn aggregation and toxicity at substoichiometric concentrations, demonstrating that it interferes with the nucleation of aggregation.
A Quantitative Analysis of Surgical Smoke Exposure as an Occupational Hazard (2021)

The air we breathe during surgery has negligible quantities of PM and mutagenic potential, likely due to low frequency of diathermy use coupled with high airflow. This suggests that exposure to surgical smoke is associated with minimal occupational risk.
Reversible long-range electron transfer in ruthenium-modified sperm whale myoglobin (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReversible long-range electron transfer in ruthenium-modified sperm whale myoglobinCharles M. Lieber, Jennifer L. Karas, and Harry B. GrayCite this: J. Am. Chem. Soc. 1987, 109, 12, 3778–3779Publication Date (Print):June 1, 1987Publication History Published online1 May 2002Published inissue 1 June 1987https://pubs.acs.org/doi/10.1021/ja00246a043https://doi.org/10.1021/ja00246a043research-articleACS PublicationsRequest reuse permissionsArticle Views184Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Supplementary Table 1 from Characterization of an Oxaliplatin Sensitivity Predictor in a Preclinical Murine Model of Colorectal Cancer (2023)

&lt;p&gt;PDF file - 63K, Oxaliplatin sensitivity data to the NCI-60 cell lines.&lt;/p&gt;
A Spatially Adaptive Antenna Array for Mm-Wave Wireless Channel Control With Microfluidics Based Reconfiguration (2020)

Spatially adaptive antenna array (SAA) is an electronically scanned antenna array with capability of changing its physical location. This new capability allows SAA to control the wireless channel environment to increase link capacity without employing an increased number of antenna elements. Compact and cost-effective implementation of SAA requires a strategically designed RF feed network that can allow the radiating antenna elements to be repositioned while other RF and digital electronics remain stationary. This manuscript introduces a novel RF feed network and demonstrates the first experimental verification of SAA by using microfluidic based reconfiguration. The presented microfluidically reconfigurable SAA (MRSA) exhibits the best possible compact form - a total footprint that is approximately equal to the spatial adaptation range. MRSA operates at 28 GHz with 45 mm ($4.2~\lambda _{0}$ ) spatial adaptation capability. Evaluating MRSA in communication systems using its measured realized gain patterns show that link level performance of the wireless channel is improved by 24% from 8.5 bps/Hz to 10.5 bps/Hz. Additionally, spectral efficiency is improved by 100% with 5 dB improvement in average signal to interference ratio.
Reduced white matter venous density is associated with neurodegeneration and cognitive impairment: a susceptibility weighted imaging study (2023)

High resolution SWI images provide unique contrast to small venous vasculature. The conspicuity of small veins on SWI venography, such as deep medullary vein in white matter (WM), is susceptible to venous blood oxygenation level changes. This study demonstrates a significant association between WM venous density and neurodegenerative feature characterized by brain atrophy in the elderly, but no significant association of WM venous density to white matter hyperintensities (WMHs) load. Further clinical correlative analysis revealed a significant correlation of WM venous density to semantic fluency and different stages of cognitive status.
Supplementary Table S1 from First-in-Human Study of the Radioligand <sup>68</sup>Ga-N188 Targeting Nectin-4 for PET/CT Imaging of Advanced Urothelial Carcinoma (2023)

&lt;p&gt;Representativeness of study participants&lt;/p&gt;
Experimental development of nuclear pumped laser candidate for inertial confinement fusion driver (1990)

A report is given on progress made during the second year of a three year contract studying the feasibility of nuclear pumping the atomic iodine laser. Experimental results are presented showing efficiencies of 25--38% at converting neutron-induced nuclear reaction energy in the excimer XeBr into UV photons which can be used to pump the laser. Parametric studies were done utilizing the {sup 10}B(n,{alpha}){sup 7}Li reaction, with three bromine donor chemicals, over a range of pressures and mix ratios, to optimize the fluorescence efficiency.
Effects of Process Time and Thread on Tensile Shear Strength of Al Alloy Lap Joint Produced by Friction Stir Spot Welding (2008)

Friction Stir Spot Welding (FSSW) has been practically used to the construction of aluminum car-body in the automotive application. In this study, the weld strength and factors governing the weld strength in friction stir spot welded aluminum alloy 6061-T6 was examined. The weld strength increased with the process time during FSSW up to 3 s, beyond which it decreased. The fracture path changed from the lapped interface into the shoulder edge as the process time increased, and the maximum strength was obtained at the process time when the transition of the fracture path occurred. The cross-sectional microstructure depended on the threads on the probe surface, i.e. the elliptical zone was formed in the stir zone by the threads, but effect of the thread on the weld strength was hardly found. The present study suggests that the weld strength was strongly related with size of the well-consolidated region which was larger than the elliptical zone observed in the vicinity of the exit hole.
Integrated Dynamic Modeling of Reformer - SOFC Systems: Novel Approaches for Fundamental Micro Scale and System Level Simulations (2005)

Novel approaches for the rigorous dynamic modeling of reformer – fuel cell systems are presented in this paper. Detailed analysis of various micro-scale transport phenomena accounting for mass and energy transport with coupled chemical reactions is carried out for modeling a methane reformer-combustor unit as part of an integrated fuel processing system currently under development at Nu Element for on-board reforming of logistics fuels for the U. S. Navy. Results from the implementations of these models in FEMLAB® are presented, followed by discussions of recent work on exporting of these models into Simulink® within MATLAB® for carrying out detailed dynamic studies. The Simulink interface is compatible with a broad range of programming tools and thus allows for integration of the models of different parts of the complete reformer – fuel cell system. This allows the user complete flexibility over the choice of the most appropriate simulation platform for each individual module. This approach also permits the seamless integration of existing SOFC models coded directly into Simulink® with the detailed reformer models described in this paper, thus opening the path for a truly flexible simulation platform for the dynamic study of reformer based fuel cell power systems.
Novel techniques for low noise microwave generation and transfer of spectral purity with optical frequency combs (2014)

International audience
Early appearance and long-term persistence of the submicroscopic extrachromosomal elements (amplisomes) containing the amplified DHFR genes in human cell lines. (1990)

Submicroscopic extrachromosomal elements (amplisomes) containing amplified dihydrofolate reductase (DHFR) genes have been investigated in a methotrexate-resistant derivative of the human cell line HeLa BU25, 10B3, by field-inversion gel electrophoresis. The amount and kinetics of formation of these elements have been correlated with the level and time course of overall DHFR gene amplification. The amplisomes account for the great majority and possibly the totality of the amplified DHFR genes in 10B3 cells. They appear very early during the development of methotrexate resistance and increase in parallel with the amplified genes. These observations suggest that these elements are involved in an early event, possibly the first event, of gene amplification in this system. Amplisomes tend to be lost from 10B3 cells in the absence of selective pressure, although much more slowly than expected from simple dilution of nonreplicating elements. Surprisingly, under selective pressure, these elements have shown no tendency to become integrated into chromosomes or to generate minute chromosomes over a period of almost 1 year, in contrast to what has been described in other systems.