gebhart/patrepeval huggingface dataset:
Long-Term Cloth-Changing Person Re-identification (2020)

Person re-identification (Re-ID) aims to match a target person across camera views at different locations and times. Existing Re-ID studies focus on the short-term cloth-consistent setting, under which a person re-appears in different camera views with the same outfit. A discriminative feature representation learned by existing deep Re-ID models is thus dominated by the visual appearance of clothing. In this work, we focus on a much more difficult yet practical setting where person matching is conducted over long-duration, e.g., over days and months and therefore inevitably under the new challenge of changing clothes. This problem, termed Long-Term Cloth-Changing (LTCC) Re-ID is much understudied due to the lack of large scale datasets. The first contribution of this work is a new LTCC dataset containing people captured over a long period of time with frequent clothing changes. As a second contribution, we propose a novel Re-ID method specifically designed to address the cloth-changing challenge. Specifically, we consider that under cloth-changes, soft-biometrics such as body shape would be more reliable. We, therefore, introduce a shape embedding module as well as a cloth-elimination shape-distillation module aiming to eliminate the now unreliable clothing appearance features and focus on the body shape information. Extensive experiments show that superior performance is achieved by the proposed model on the new LTCC dataset. The code and dataset will be available at https://naiq.github.io/LTCC_Perosn_ReID.html.
Poly(2-methoxyethyl acrylate) (PMEA) improves the thromboresistance of FRED flow diverters: a thrombogenic evaluation of flow diverters with human blood under flow conditions (2022)

The X Technology surface modification of FRED X demonstrated superior thromboresistant properties over untreated FRED while maintaining comparable cellular adhesion. Taken together, these properties may help mitigate material-related thromboembolic complications.
Detection of phosphorylation states by intermolecular sensitization of lanthanide–peptide conjugates (2012)

The luminescence of a designed peptide equipped with a coordinatively-unsaturated lanthanide complex is modulated by the phosphorylation state of a serine residue in the sequence. While the phosphorylated state is weakly emissive, even in the presence of an external antenna, removal of the phosphate allows coordination of the sensitizer to the metal, yielding a highly emissive supramolecular complex.
MP57-05 DOES A SHORTER INTERVAL BETWEEN THE PERFORMANCE OF PROSTATE BIOPSY AND ROBOT-ASSISTED RADICAL PROSTATECTOMY AFFECT OUTCOMES? (2016)

67%, 7 in 28% and 8 in 5%. Final pathology showed that 11% had pT3a disease, 6% had pT3b disease and 2% had pN1 disease. Regarding the Gleason score, 13% had primary Gleason pattern 4 (4+3 and up), 48% had secondary Gleason pattern 4 (3+4) and 2% had secondary Gleason 5 (3+5 or 4+5). Regarding the maximal tumor diameter 21% had a diameter <10mm, and 55% < 20mm. When limiting the analysis to expert reading only, the numbers improved. No patient had pT3 disease (p<0.05), only 4% had primary Gleason pattern 4, but 57% had secondary Gleason pattern 4 (3+4) (p<0.05). Regarding the maximal tumor diameter, patients showed smaller lesions with 34% having a diameter <10mm, and 84% < 20mm (p<0.05).
Microtubule-associated Proteins 1 (MAP1) Promote Human Immunodeficiency Virus Type I (HIV-1) Intracytoplasmic Routing to the Nucleus (2014)

After cell entry, HIV undergoes rapid transport toward the nucleus using microtubules and microfilaments. Neither the cellular cytoplasmic components nor the viral proteins that interact to mediate transport have yet been identified. Using a yeast two-hybrid screen, we identified four cytoskeletal components as putative interaction partners for HIV-1 p24 capsid protein: MAP1A, MAP1S, CKAP1, and WIRE. Depletion of MAP1A/MAP1S in indicator cell lines and primary human macrophages led to a profound reduction in HIV-1 infectivity as a result of impaired retrograde trafficking, demonstrated by a characteristic accumulation of capsids away from the nuclear membrane, and an overall defect in nuclear import. MAP1A/MAP1S did not impact microtubule network integrity or cell morphology but contributed to microtubule stabilization, which was shown previously to facilitate infection. In addition, we found that MAP1 proteins interact with HIV-1 cores both in vitro and in infected cells and that interaction involves MAP1 light chain LC2. Depletion of MAP1 proteins reduced the association of HIV-1 capsids with both dynamic and stable microtubules, suggesting that MAP1 proteins help tether incoming viral capsids to the microtubular network, thus promoting cytoplasmic trafficking. This work shows for the first time that following entry into target cells, HIV-1 interacts with the cytoskeleton via its p24 capsid protein. Moreover, our results support a role for MAP1 proteins in promoting efficient retrograde trafficking of HIV-1 by stimulating the formation of stable microtubules and mediating the association of HIV-1 cores with microtubules.
Stem-Cell Therapy Mitigates Radiation-Induced Non-Union in Murine Mandibular Distraction Osteogenesis (2011)

Deshpande, Sagar BS; Gallagher, Kelly MD; Donneys, Alexis MD; Tchanque-Fossuo, Catherine MD; Nelson, Noah BS; Sarhaddi, Deniz BS; Sun, Hongli PhD; Krebsbach, Paul DDS, PhD; Buchman, Steven MD
Discovery of a Hidden Trypanosoma cruzi Spermidine Synthase Binding Site and Inhibitors through In Silico, In Vitro , and X-ray Crystallography (2023)

In drug discovery research, the selection of promising binding sites and understanding the binding mode of compounds are crucial fundamental studies. The current understanding of the proteins-ligand binding model extends beyond the simple lock and key model to include the induced-fit model, which alters the conformation to match the shape of the ligand, and the pre-existing equilibrium model, selectively binding structures with high binding affinity from a diverse ensemble of proteins. Although methods for detecting target protein binding sites and virtual screening techniques using docking simulation are well-established, with numerous studies reported, they only consider a very limited number of structures in the diverse ensemble of proteins, as these methods are applied to a single structure. Molecular dynamics (MD) simulation is a method for predicting protein dynamics and can detect potential ensembles of protein binding sites and hidden sites unobservable in a single-point structure. In this study, to demonstrate the utility of virtual screening with protein dynamics, MD simulations were performed on <i>Trypanosoma cruzi</i> spermidine synthase to obtain an ensemble of dominant binding sites with a high probability of existence. The structure of the binding site obtained through MD simulation revealed pockets in addition to the active site that was present in the initial structure. Using the obtained binding site structures, virtual screening of 4.8 million compounds by docking simulation, <i>in vitro</i> assays, and X-ray analysis was conducted, successfully identifying two hit compounds.
Supplementary Figure S6 from Preclinical Activity of SAR408701: A Novel Anti-CEACAM5–maytansinoid Antibody–drug Conjugate for the Treatment of CEACAM5-positive Epithelial Tumors (2023)

&lt;p&gt;Supplementary Figure S6&lt;/p&gt;
Gold nanoparticles in the clinical laboratory: principles of preparation and applications (2011)

In order to meet the challenges of effective healthcare, the clinical laboratory is constantly striving to improve testing sensitivity while reducing the required time and cost. Gold nanoparticles (AuNPs) are proposed as one of the most promising tools to meet such goals. They have unique optophysical properties which enable sensitive detection of biomarkers, and are easily amenable to modification for use in different assay formats including immunoassays and molecular assays. Additionally, their preparation is relatively simple and their detection methods are quite versatile. AuNPs are showing substantial promise for effective practical applications and commercial utilization is already underway. This article covers the principles of preparation of AuNPs and their use for development of different diagnostic platforms.
Synthesis, Structure, and Photochemistry of 5,14‐Diketopentacene (2012)

Abstract 5,14‐α‐Diketopentacene, a structural isomer of 6,13‐α‐diketopentacene, was prepared from pentacene in three steps. In addition to the typical n–π* absorption of the diketone moiety at around 468 nm and the anthracene‐like absorption at 333, 349, and 367 nm, a broad absorption was observed at around 386 nm, which could be assigned to an intramolecular charge‐transfer absorption from anthracene to the diketone moiety. 5,14‐α‐Diketopentacene could be converted into pentacene quantitatively by photoirradiation at 405 and 468 nm in toluene with quantum yields of 2.3 and 2.4 %, respectively, and these values are higher than the quantum yield of 1.4 % obtained for 6,13‐α‐diketopentacene irradiated at 468 nm. The quantum yields in acetonitrile were lowered to 0.33 and 0.28 % with irradiation at 405 and 468 nm. The crystal structure of 5,14‐α‐diketopentacene showed a CH–π interaction and π–π stacking between neighbouring anthracene and benzene moieties. The lower solubility of 5,14‐α‐diketopentacene compared with the 6,13‐isomer could be explained by this crystal structure.
Combined Use of Endovascular and Standard Operative Procedures for the Treatment of Multiple Aortoiliac Pseudoaneurysms (1996)

New endovascular procedures are increasing the options available to the vascular surgeon for the treatment of arterial disease. These techniques, alone or in combination with conventional surgical techniques, may allow the safer treatment of complex aortoiliac pathology, particularly in patients with comorbid medical illnesses who have high morbidity and mortality rates associated with open surgical repair. The authors describe the successful treatment of two noninfected aortoiliac false aneurysms eight years after the original arterial reconstruction with a bifurcated graft. The pseudoaneurysms were treated by use of a combination of endovascular and standard surgical techniques in a patient with significant comorbid medical conditions that limited standard surgical repair.
CAD for the design and evaluation of industrial control systems (1984)

The paper reviews the current state of development of a CAD facility for the design and evaluation of industrial process control systems. The facility is generalised to support multiple control systems and to coordinate their operations. The individual control systems may involve compensation for interaction, disturbance and time delay. The design procedures use least-squares analysis for identification, dynamic programming for control system design and simulation for evaluation of performance. The facility permits a systematic approach for building sets of hierarchical controllers with the objective of supervising the operation of complex processes. Design studies relating to real plant data are presented.
An innovative application of polymer swelling by scCO2 : their nanostructuration with inorganic nanoparticles (2008)

International audience
Selective quantification of cardiac sympathetic and parasympathetic nervous function based on the heart rate baroreflex impulse response (2006)

We introduce an improved technique for selectively quantifying cardiac sympathetic and parasympathetic nervous function based on the identification of the heart rate (HR) baroreflex impulse response from non-invasive cardio-respiratory measurements. We have tested the technique with respect to 24 humans breathing randomly or spontaneously under selective pharmacological autonomic blockade. Our results show that the technique performs much better than traditional HR power spectral indices in terms of predicting the known drug effects and is effective during spontaneous breathing. 1.
Synthesis of silica glasses doped with SiAl ON phosphors by supercritical drying (2016)

Abstract Silica gels and glasses doped with SiAl ON phosphors have been synthesized by the sol‐gel method. Only after half a day of supercritical drying, the dried gels with many mesopores and high surface‐specific area were obtained. The chromaticity of the gels can be controlled to vary widely from blue to yellow by changing the heating temperature, SiAl ON concentration, and sample thickness. The thermal dependence of photoluminescence of the glass is similar to that of SiAl ON powder.
GOTA: GO term annotation of biomedical literature (2015)

GOTA implements a flexible and expandable model for GO annotation of biomedical literature. The current version of the GOTA tool is freely available at http://gota.apice.unibo.it.
Antisense Approaches for the Treatment of Cancer (2000)

(2000). Antisense Approaches for the Treatment of Cancer. Cancer Investigation: Vol. 18, No. 7, pp. 635-650.
<title>Large-scale holographic associative memory controlled by external constraints</title> (1994)

We present a large-scale holographic associative memory system of binary images, with which an electronic digital computer is incorporated to realize a high performance and to combine a logical processing using external constraints. In the system, associative process is performed in two steps, correlation and image synthesis steps. In the correlation step we execute a simple nonlinear operation, and in the image synthesis step we introduce an external input based on the prior knowledge about the expected output. This external input lets us control the output of the system. In the optical implementation we use spatially multiplexed Fourier transformed holograms. Experimental demonstrations are given to illustrate the performance of the system and the effectiveness of the external input.
Electrospray Needle (2016)

This document contains recommendations for terminology in mass spectrometry. Development of standard terms dates back to 1974 when the IUPAC Commission on Analytical Nomenclature issued recommendations on mass spectrometry terms and definitions. In 1978, the IUPAC Commission on Molecular Structure and Spectroscopy updated and extended the recommendations and made further recommendations regarding symbols, acronyms, and abbreviations. The IUPAC Physical Chemistry Division Commission on Molecular Structure and Spectroscopy’s Subcommittee on Mass Spectroscopy revised the recommended terms in 1991 and appended terms relating to vacuum technology. Some additional terms related to tandem mass spectrometry were added in 1993 and accelerator mass spectrometry in 1994. Owing to the rapid expansion of the field in the intervening years, particularly in mass spectrometry of biomolecules, a further revision of the recommendations has become necessary. This document contains a comprehensive revision of mass spectrometry terminology that represents the current consensus of the mass spectrometry community.
Statistical modeling of fading and diversity for outdoor 60 GHz channels (2010)

While there is significant ongoing effort in indoor applications of 60 GHz unlicensed wireless communication, the 60 GHz band also has significant potential in providing an easily deployable outdoor broadband infrastructure, using mesh networks with link ranges of the order of hundreds of meters. In this paper, we investigate the statistics of a typical lamppost-to-lamppost 60 GHz link by using ray tracing. Due to the directionality of the link, the multipath is sparse but strong, leading to significant fades that must be combated using multiple antennas. We show that the diversity provided by a 2 by 2 Multiple Input Multiple Output (MIMO) link with moderate antenna separation is sufficient for robust link performance. The two schemes we consider are transmit precoding along the dominant eigenmode (which requires channel state information at the transmitter) and the Alamouti space-time coding (which does not). We also show that the channel coefficients are well modeled as complex Gaussian with nonzero means, but the channel capacity is slightly overestimated by a Gaussian model whose correlations match those obtained from ray tracing.
Test-Retest Reproducibility of Conventional Quantitative Parameters on PSMA-targeted 18F-DCFPyL PET/CT in Patients with Metastatic Prostate Cancer (2021)

1317 Objectives: Prostate-specific membrane antigen (PSMA)-targeted 18F-DCFPyL has proven to detect metastatic prostate cancer (PC) with high accuracy. In this study, we evaluated 18F-DCFPyL test-retest reproducibility of conventional quantitative parameters in widespread disease. Methods: In a prospective clinical trial (NCT03793543), 23 patients with histologically proven PC underwent two 18F-DCFPyL PET scans within 7 days (mean 3.7, range 1 to 7d). Lesions in bone, lymph nodes and other organs were manually segmented on both scans and quantitative parameters were assessed (mean [SUVmean] and maximum [SUVmax] standardized uptake values, PSMA-tumor volume [PSMA-TV] and total lesion PSMA [TL-PSMA, SUV x TV]). Repeatability of quantification was determined using correlations and within-subject coefficient of variation (wCOV, in %; 30% unacceptable reproducibility). Results: In total, 229 lesions (176 bone, 38 lymph nodes, 15 others) were delineated in both scans. For all investigated parameters, a high inter-scan correlation was found (R2≥0.98). Analyzing all lesions, the wCOVs for SUVmax and SUVmean were 12.1% and 7.3%, respectively, indicating good to excellent reproducibility for PSMA expression derived by SUV. The wCOV of LN, however, were significantly lower relative to those derived from osseous lesions (SUVmean: LN, 3.8% vs. skeleton, 7.8%, p
Thermal stability of electrodeposited platinum nanowires and morphological transformations at elevated temperatures (2012)

Pt nanowires were prepared by template electrodeposition using ion track etched polymer membranes and analysed with respect to their thermal stability. Driven by Rayleigh instability, the polycrystalline Pt nanostructures experienced structural transformations and finally fragmented into linear chains of nanospheres at temperatures much below the melting point of bulk Pt. Morphological changes were systematically studied by electron microscopy and compared with previously reported results on other metal nanowires and theoretical predictions. In addition, nanowires could readily be interconnected to two-dimensional assemblies by taking advantage of the rapid diffusion processes. This study will help to predict the durability of integrated nanowires and contributes to the understanding of thermal-induced transformations for polycrystalline nanowires.
Transcript degradation and noise of small RNA-controlled genes in a switch activated network inEscherichia coli (2016)

Post-transcriptional regulatory processes may change transcript levels and affect cell-to-cell variability or noise. We study small-RNA downregulation to elucidate its effects on noise in the iron homeostasis network of Escherichia coli In this network, the small-RNA RyhB undergoes stoichiometric degradation with the transcripts of target genes in response to iron stress. Using single-molecule fluorescence in situ hybridization, we measured transcript numbers of the RyhB-regulated genes sodB and fumA in individual cells as a function of iron deprivation. We observed a monotonic increase of noise with iron stress but no evidence of theoretically predicted, enhanced stoichiometric fluctuations in transcript numbers, nor of bistable behavior in transcript distributions. Direct detection of RyhB in individual cells shows that its noise is much smaller than that of these two targets, when RyhB production is significant. A generalized two-state model of bursty transcription that neglects RyhB fluctuations describes quantitatively the dependence of noise and transcript distributions on iron deprivation, enabling extraction of in vivo RyhB-mediated transcript degradation rates. The transcripts' threshold-linear behavior indicates that the effective in vivo interaction strength between RyhB and its two target transcripts is comparable. Strikingly, the bacterial cell response exhibits Fur-dependent, switch-like activation instead of a graded response to iron deprivation.
Modern Management of Spinal Tuberculosis Clinical Study (1995)

The resurgence of pulmonary tuberculosis in the United States has been paralleled by a concomitant rise in tuberculosis of the spine (Pott's disease). The appearance of drug-resistant strains of tuberculosis, infection in large numbers of immunocompromised hosts, newer imaging modalities, and the development of more effective spinal reconstruction techniques have raised important issues regarding the management of Pott's disease. In spite of this, there has been little published recently on the modern management of Pott's disease in developed countries. We report our experience with the management of 20 patients with Pott's disease in the past 5 years, 16 of whom were admitted during the last 18 months of this retrospective study. The mean patient age was 49 years. Sixteen (80%) were men. Nineteen (95%) had a positive tuberculin skin test, and 13 (65%) had pulmonary tuberculosis. Symptoms consisted of spinal pain, weakness, sensory complaints, and flank mass in order of decreasing frequency. Ten patients were neurologically intact; the remainder had motor deficits of variable severity. The thoracic spine was involved in 13 patients, the lumbar spine was involved in 4, the cervical spine was involved in 2, and the thoracolumbar spine was involved in 1. Spinal deformity was present in 11 patients, spinal epidural compression was present in 13, and a paraspinal mass was present in 18. Operative indications included motor deficits, spinal deformity, nondiagnostic computer tomographic-guided needle biopsy, and noncompliance with, or lack of, response to medical therapy. Eleven patients underwent operations. Six patients had vertebrectomy and bone grafting with posterior instrumentation when indicated; three had laminectomy, debridement, and abscess drainage; one had laminectomy and posterior instrumentation; and one had paraspinal abscess drainage. Two patients have died; the remainder have been monitored for at least 1 year and are neurologically improved or normal without residual infection. The average angulation decreased from 31 to 24 degrees by the follow-up examination. In selected patients, early operative treatment with instrumentation, when indicated, minimizes neurological deterioration and spinal deformity, allows early ambulation, and results in excellent neurological outcome.
Fine tuning of surface CRLF2 expression and its associated signaling profile in childhood B-cell precursor acute lymphoblastic leukemia (2015)

Genomic rearrangements of the cytokine receptor-like factor 2 (CRLF2) gene,[1][1],[2][2] which is part of the thymic stromal lymphopoietin receptor (TSLPR), result in overexpression of CRLF2 itself leading to JAK2-mediated activation of STAT5, which regulates cell proliferation, survival, and
Capillary zone electrophoresis for bottom‐up analysis of complex proteomes (2015)

Capillary zone electrophoresis (CZE) is emerging as a useful tool in proteomic analysis. Interest arises from dramatic improvements in performance that result from improvements in the background electrolyte used for the separation, the incorporation of advanced sample injection methods, the development of robust and sensitive electrospray interfaces, and the coupling with Orbitrap mass spectrometers with high resolution and sensitivity. The combination of these technologies produces performance that is rapidly approaching the performance of UPLC-based methods for microgram samples and exceeds the performance of UPLC-based methods for mid- to low nanogram samples. These systems now produce over 10 000 peptide IDs in a single 100-min analysis of the HeLa proteome.