gebhart/patrepeval huggingface dataset:
Kombinatorische Materialforschung und Katalyse (1999)

Nach dem Paradigmenwechsel, der in der pharmazeutischen Industrie stattfand, als durch kombinatorische Methoden der Prozeß zur Entdeckung neuer Wirkstoffe unwiderruflich verändert wurde, werden nun kombinatorische Methoden in zunehmendem Maße auch zur Entdeckung und Optimierung neuer und effizienterer Katalysatoren und Materialien eingesetzt (siehe Abbildung). Mit der Entwicklung und dem Einzug neuer kombinatorischer Synthese- und Screening-Methoden, kombiniert mit integrierter Datenverwaltung, eröffnet die Anwendung dieser Methoden in den Materialwissenschaften und der Katalysatorforschung ein enormes Potential und erweckt hohe Erwartungen in dieser neuen und aufregenden Disziplin.
Investigating the Potential for Long-Term Permeable Reactive Barrier (PRB) Monitoring from the Electrical Signatures Associated with the Reduction in Reactive Iron Performance (2003)

The objective of this project is to quantify the ability of the electrical induced polarization (IP) method to non-invasively monitor the reduction in reactive iron performance that is known to reduce the effectiveness of the permeable reactive barrier (PRB) with time. The primary scientific goals include: (1) fundamental laboratory studies to evaluate the sensitivity of the IP method to: Fe0 total surface area Fe0 surface chemistry physical/chemical changes to the Fe0 surface resulting from oxidation and precipitation (2) monitoring of the electrical tomographic response of the Kansas City PRB over a three-year period and assessment, via correlation with aqueous geochemical data and extracted iron cores, of whether electrical signatures associated with reduced PRB performance are resolvable in field studies (3) optimization of a three-dimensional tomographic imaging algorithm for application to highly conductive, high electrical contrast environments as represented by a PRB IP theory and empirical data resulting from the original development of the method for mineral exploration suggests that the method is highly relevant in the study of reactive iron barriers. Laboratory and field IP studies on mineral deposits illustrate the sensitivity of IP parameters to metal concentration, particle size and metal surface chemistry. IP theory, based on electrical (Warburg) impedance associated with diffusive ion transfer to/from the electrolyte to electron exchange sites on the metal surface, provides a framework for interpreting IP signatures of PRBs as a function of redox chemistry.
Dynamic roles for NF‐κB in HTLV‐I and HIV‐1 retroviral pathogenesis (2012)

Viruses and hosts are involved in a continuing 'arms race'. The body deploys multiple defenses; however, viruses utilize generally superior and more rapidly evolving tactics for negating host immune surveillance and viral clearance. In the case of the two major pathogenic human retroviruses, human immunodeficiency virus-1 (HIV-1) and human T-lymphotrophic virus-I (HTLV-I), the nuclear factor-κB (NF-κB) transcription factor plays a key role in the host's anti-viral responses involving both the innate and adaptive arms of the immune response. Similarly, these retroviruses capably exploit NF-κB for their replication, spread, and pathogenic functions. In this review, we discuss the dynamic and intimate interplay that occurs between NF-κB and the HTLV-I and HIV-1 retroviral pathogens.
Shear Strengthening of Reinforced Concrete with CFRP (2000)

For about 10 years now, composite plates such as CFRP (Carbon Fibre Reinforced Plastic) have been state of the art for post-&lt;em&gt;flexural&lt;/em&gt; strengthening of existing reinforced concrete structures. Thanks to a new innovation called 'L-shaped CFRP plates', it is now possible to &lt;em&gt;shear&lt;/em&gt;-strengthen reinforced concrete structures. This contribution presents tests of L-shaped CFRP plates and CFRP fabrics, and highlights the possibilities and limitations of this new technology.
A study of zinc sulfate decomposition at low heating rates (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA study of zinc sulfate decomposition at low heating ratesRavi Narayan, Ali Tabatabaie-Raissi, and Michael Jerry Antal Jr.Cite this: Ind. Eng. Chem. Res. 1988, 27, 6, 1050–1058Publication Date (Print):June 1, 1988Publication History Published online1 May 2002Published inissue 1 June 1988https://doi.org/10.1021/ie00078a026Request reuse permissionsArticle Views493Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alertsclose Get e-Alerts
Visual Perception and Evaluation of Photo-Realistic Self-Avatars From 3D Body Scans in Males and Females (2018)

The creation or streaming of photo-realistic self-avatars is important for virtual reality applications that aim for perception and action to replicate real world experience. The appearance and recognition of a digital self-avatar may be especially important for applications related to telepresence, embodied virtual reality, or immersive games. We investigated gender differences in the use of visual cues (shape, texture) of a self-avatar for estimating body weight and evaluating avatar appearance. A full-body scanner was used to capture each participant's body geometry and color information and a set of 3D virtual avatars with realistic weight variations was created based on a statistical body model. Additionally, a second set of avatars was created with an average underlying body shape matched to each participant’s height and weight. In four sets of psychophysical experiments, the influence of visual cues on the accuracy of body weight estimation and the sensitivity to weight changes was assessed by manipulating body shape (own, average) and texture (own photo-realistic, checkerboard). The avatars were presented on a large-screen display, and participants responded to whether the avatar's weight corresponded to their own weight. Participants also adjusted the avatar's weight to their desired weight and evaluated the avatar's appearance with regard to similarity to their own body, uncanniness, and their willingness to accept it as a digital representation of the self. The results of the psychophysical experiments revealed no gender difference in the accuracy of estimating body weight in avatars. However, males accepted a larger weight range of the avatars as corresponding to their own. In terms of the ideal body weight, females but not males desired a thinner body. With regard to the evaluation of avatar appearance, the questionnaire responses suggest that own photo-realistic texture was more important to males for higher similarity ratings, while own body shape seemed to be more important to females. These results argue for gender-specific considerations when creating self-avatars.
Abstract 833: Anti-tumor efficacy of BA3021, a novel Conditionally Active Biologic (CAB) anti-ROR2 ADC (2018)

Abstract ROR2 is a developmentally regulated member of the receptor tyrosine kinase orphan receptor (ROR) family and is a non-canonical receptor for selected Wnt family members. Many of the activities associated with ROR2 in development have also been implicated in cancer including cell migration and invasion. In many cancer types, expression of ROR2 correlates with advanced disease or poor prognosis. The high level of expression on the cancer cell surface has made it an attractive target for antibody-drug-conjugates (ADC). The Conditionally Active Biologics (CAB) technology is a patented, proprietary platform that selects antibodies that reversibly bind to target antigen in the context of diseased tissues, but not normal tissues, by taking advantage of the unique cancer microenvironment that is produced largely as a result of the Warburg effect. Using our CAB technology, we have identified anti-ROR2 selective Abs that reversibly bind to recombinant ROR2 and ROR2 expressing cells under conditions that are present in the tumor microenvironment, but not in normal tissues. BA3021 is a CAB-ROR2-ADC. The pharmacological properties of BA3021 were characterized in a number of in vitro and in vivo pharmacology studies. BA3021 binds selectively to human and cyno ROR2 in conditions reflective of the tumor microenvironment, but has reduced binding under normal tissue conditions. BA3021 demonstrated ability to induce cytotoxicity of cell lines expressing ROR2 in vitro and inhibit tumor growth in LCLC-103H (lung), MDA-MB-436 (breast), HT1080 (sarcoma) and SK-MEL-5 (melanoma) human tumor xenografts and in selected sarcoma cancer patient derived xenograft models in vivo. In conclusion, our data is consistent with our work on CAB-EGFR-ADC, CAB-AXL-ADC, CAB-PD-1 and other CAB programs and suggests that ADCs generated using the CAB technology provide biologics with increased therapeutic index. Specifically, the CAB-ROR2-ADC is an excellent candidate for evaluation as a treatment for human cancers that are ROR2 positive. Citation Format: Leslie L. Sharp, Cathy Chang, Gerhard Frey, Jing Wang, Haizhen Liu, Charles Xing, Safak Yalcin, Marlena Walls, Yong Ben, William J. Boyle, Jay M. Short. Anti-tumor efficacy of BA3021, a novel Conditionally Active Biologic (CAB) anti-ROR2 ADC [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 833.
Challenges associated with three dimensional phase field modeling of ferroelectric single crystal phase transformations (2009)

This paper discusses phase field modeling of tetragonal and rhombohedral ferroelectric domain structures using three dimensional grids. The work is based on the time dependent Ginsberg-Landau (TDGL) equation in which the free energy of the system is minimized subject to constraints on the boundaries of the system. Details are presented regarding the determination of energy functions and the effects of stress and electric field on these functions.
Paroxysmal Sympathetic Hyperactivity in Pediatric Rehabilitation: Pathological Features and Scheduled Pharmacological Therapies (2016)

Results should be interpreted carefully regarding causal relationships and drug doses and combinations, but they encourage further studies on the use of propranolol and diazepam to favor PSH remission.
The Peer Obervation: "Mentore" Project at the University of Palermo (2019)

During the last six years, at the University of Palermo, a group of academics has been involved in a project called “MENTORE” (“Modifying and ENhancing Teaching through peer Observation and Reflections with Experts”). The objectives of the project are: to help teachers improve their teaching, through the help of two mentors; to experiment new approaches in pilot courses to extend, if useful, to other ones; and to change the traditional model of academic teaching based on one single teacher with the class to go towards a model where there is a group of teachers working together in search of improvements. &#13;\nAll the participants of the MENTORE project attend to lectures/workshops on teaching and learning and participate to meetings where they share experiences and ideas. In the program, each participant has two mentors that help him/her to improve the quality of his/her teaching. The two mentors are other academics that participate to the program. Indeed, each participant is both mentor and mentee during the same year. Mentors follow some of the lectures of the mentee, meet the students in the final part of the course in order to collect their opinion and, finally, meet the mentee in order to discuss the actions to carry out for improving the quality of his/her teaching. This chapter describes the aforementioned peer observation practice adopted at the University of Palermo and focuses on the role of mentors describing their activities during the peer observation process
A Virtual Pyrogram Generator to Resolve Complex Pyrosequencing Results (2012)

We report a freely available software program, Pyromaker, which generates simulated traces for pyrosequencing results based on user inputs. Simulated pyrograms can aid in the analysis of complex pyrosequencing results in which various hypothesized mutations can be tested, and the resultant pyrograms can be matched with the actual pyrogram. We validated the software using the actual pyrograms for common KRAS gene mutations as well as several mutations in the BRAF, GNAS, and p53 genes. We demonstrate that all 18 possible single-base mutations within codons 12 and 13 of KRAS generate unique pyrosequencing traces and highlight the distinctions between them. We further show that all reported codon 12 and 13 complex mutations produce unique pyrograms. However, some complex mutations are indistinguishable from single-base mutations. For complicated pyrograms, Pyromaker was used in two modes, one in which hypothesis-based simulated pyrograms were pattern-matched with the actual pyrograms. In a second strategy with only the pyrogram, Pyromaker was used to identify the underlying mutation by iteratively reconstructing the mutant pyrogram. Either strategy was able to successfully identify the complex mutations, which were confirmed by cloning and sequencing. Using two examples of KRAS codon 12 mutations (specifically GGT→TTT, G12F and GGT→GAG, G12E), we report which combinations of five approaches permit unambiguous mutation identification. The most efficient approach was found to be pyrosequencing with Pyromaker.
Central serous chorioretinopathy imaging biomarkers (2020)

OCT parameters such as changes in both CMT and SFCT along with subfoveal EZ damage can be predictive of disease resolution whereas changes in CMT and baseline SRF height correlate well with changes in BCVA through 12 months.
Abstract 3849: HNO Induces a Disulfide Bond Between Cysteine Residues on Actin (Cys 257) and Tropomyosin (Cys 190) Increasing Cardiac Force Development: A Novel, Redox-based Mechanism for Contractile Regulation (2009)

Background: Nitroxyl (HNO) donors increase cardiac inotropy via combined enhancement of SR Ca2+ cycling and myofilament sensitization to Ca2+. HNO reacts with thiols, but the critical -SH targets o...
Automatic workload generation for system-level exploration based on modified GCC compiler (2010)

Future embedded system products, e.g. smart hand-held mobile terminals, will accommodate a large number of applications that will partly run sequentially and independently, partly concurrently and interacting on massively parallel computing platforms. Already for systems of moderate complexity, the design space will be huge and its exploration requires that the system architect is able to quickly evaluate the performances of candidate architectures and application mappings. The mainstream evaluation technique today is the system-level performance simulation of the applications and platforms using abstracted workload and processing capacity models, respectively. These virtual system models allow fast simulation of large systems at an early phase of development with reasonable modeling effort and time. The accuracy of the performance results is dependent on how closely the models used reflect the actual system. This paper presents a compiler based technique for automatic generation of workload models for performance simulation, while exploiting an overall approach and platform performance capacity models developed previously. The resulting workload models are experimented using x264 video and JPEG encoding application examples.
Efficient Analysis of Electromagnetic Scattering in Post-Wall Waveguides and Its Application to Optimization of Millimeter Wave Filters (2020)

Functional post-wall waveguides and waveguide based compact passive circuits - namely bandpass filters - that are formed by introducing additional metallic or dielectric posts inside the post-wall waveguide are analyzed. Scattering parameters (S-parameters) of the waveguide-based bandpass filters are calculated using the method of images combined with the lattice sums technique. The developed formulation is numerically very fast, hence it can be considered as one of the best-suited approaches for the analysis of multiple scattering in post-wall waveguides and for numerical structural optimization. A breeder genetic algorithm is employed as a global search heuristic in order to track down the optimal geometrical parameters for the introduced posts yielding a bandpass filter characteristic in the desired frequency bands. Comparison with other references validates the correctness and utility of our formalism. Different configurations for the specifications of post-wall waveguide-based bandpass filters are discussed.
Cholesterol sulfotransferase (Sult2b1) inactivates oxysterol ligands of LXR (2006)

Sult2b1b catalyzes the sulfation of cholesterol, oxysterols, and dehydoepiandrosterone (DHEA). Oxysterols are ligands of the liver X receptor (LXR), a member of the nuclear receptors. We utilized in vitro and in vivo systems to show that over‐expression of Sult2b1b inactivates oxysterol ligands of LXR. In transfected HEK293 cells, oxysterols and a non‐sterol agonist of LXR (T0901317) stimulate the transcription of LXR‐responsive promoters. Co‐transfection of a cDNA encoding Sult2b1b led to partial inactivation of the stimulation mediated by the oxysterols 22‐hydroxylcholesterol and 24, 25‐epoxycholesterol but not that by T0901317. In stable cell lines expressing Sult2b1 from an inducible promoter, oxysterols and T0901317 induced the expression of an endogenous LXR target gene, ABCA1. Induction of Sult2b1b partially inactivated oxysterol but not T0901317 stimulation of ABCA1. In RAW macrophages, oxysterols and T0901317 induced two LXR target genes, ABCA1 and SREBP1c. Infection of these cells with an adenovirus expressing Sult2b1b inactivated stimulation by oxysterols but not that by T0901317. In primary rat hepatocytes, insulin and T0901317 stimulate expression of SREBP1c via LXR. Infection of these cells with the Sult2b1b adenovirus inactivated the insulin effect but not the T0901317 effect. Feeding mice a diet containing 1% cholesterol or T0901317 induced the expression of multiple LXR target genes, and the induction mediated by cholesterol but not that affected by T0901317 was inactivated by infection with the Sult2b1 expressing adenovirus. We conclude that oxysterols may be endogenous ligands for LXR and that their effects can be ameliorated by over‐expression of a catabolic enzyme. (This research was support by NIH grant AR51943).
Compressing and Querying Integer Dictionaries Under Linearities and Repetitions (2022)

We revisit the fundamental problem of compressing an integer dictionary that supports efficient rank and select operations by exploiting simultaneously two kinds of regularities arising in real data: <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">repetitiveness</i> and <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">approximate linearity</i> . We attack this problem by proposing two novel compressed indexing approaches that extend the classic Lempel-Ziv compression scheme and the more recent block tree data structure with new algorithms and data structures that allow them to also capture regularities in terms of the approximate linearity in the data. Finally, we corroborate these theoretical results with a wide set of experiments on real and synthetic datasets, which allow us to show that our approaches achieve new interesting space-time trade-offs that characterise them as more robust in most practical scenarios compared to the known data structures that exploit only one of the two regularities.
Discovery of BMS-986251: A Clinically Viable, Potent, and Selective RORγt Inverse Agonist (2020)

Novel tricyclic analogues were designed, synthesized, and evaluated as RORγt inverse agonists. Several of these compounds were potent in an IL-17 human whole blood assay and exhibited excellent oral bioavailability in mouse pharmacokinetic studies. This led to the identification of compound <b>5</b>, which displayed dose-dependent inhibition of IL-17F production in a mouse IL-2/IL-23 stimulated pharmacodynamic model. In addition, compound <b>5</b> was studied in mouse acanthosis and imiquimod-induced models of skin inflammation, where it demonstrated robust efficacy comparable to a positive control. As a result of this excellent overall profile, compound <b>5</b> (BMS-986251) was selected as a clinically viable developmental candidate.
Comparison of calibrated and uncalibrated bone mineral density by CT to DEXA in menopausal women (2011)

Uncalibrated measures of thoracic spine vBMD obtained from CT scans of the heart may provide clinically relevant information about bone health and osteoporosis/osteopenia risk in recently menopausal women.
Provenance for nested subqueries (2009)

Data provenance is essential in applications such as scientific computing, curated databases, and data warehouses. Several systems have been developed that provide provenance functionality for the relational data model. These systems support only a subset of SQL, a severe limitation in practice since most of the application domains that benefit from provenance information use complex queries. Such queries typically involve nested subqueries, aggregation and/or user defined functions. Without support for these constructs, a provenance management system is of limited use.
Zone-specific collagen alignment in porous polymer scaffolds for articular cartilage tissue engineering (2016)

Frontiers Events is a rapidly growing calendar management system dedicated to the scheduling of academic events. This includes announcements and invitations, participant listings and search functionality, abstract handling and publication, related events and post-event exchanges. Whether an organizer or participant, make your event a Frontiers Event!
Holographic Encoding of Permanent Gratings Embedded in Diamond by Two Beam Interference of a Single Femtosecond Near-Infrared Laser Pulse (2000)

It is reported on the first demonstration that non-erasable gratings may be holographically encoded in diamonds by colliding a pair of pulses split from a single high peak power femtosecond laser pulse using a Ti: sapphire laser. Confocal microscopic observation revealed that gratings are formed beneath the top surface at ∼0.5 to ∼1.5 µm. Conversion of diamond into diamond-like or amorphous carbon occurs in the encoded portion, resulting in the refractive index modulation. The present method is applicable for encoding volume holograms for all crystalline and amorphous transparent dielectrics including sapphire, LiNbO 3 , SiC, ZnSe and various types of glass.