gebhart/patrepeval huggingface dataset:
<title>Microendoscopy of the eustachian tube and the middle ear</title> (1992)

Progressive miniaturization of flexible fiberoptic instruments has made it possible to perform atraumatic endoscopy of the Eustachian tube and tympanic cavity with an intact ear drum. By means of a special set of carrier- and balloon-catheters which are partly actively steerable, flexible microendoscopes with outside diameters of 290 - 700 micrometers are inserted through the nasal cavity into the nasopharyngeal opening of the Eustachian tube and carefully advanced into the middle ear compartment under permanent direct visual control. Second generation microendoscopes with outside diameters of 750 to 1000 micrometers are equipped with a one- direction tip-steering mechanism which allows deflection up to 90 degrees. In addition to it, the use of two special types of four-function scopes (outside diameter: 1.6 mm and 1.8 mm) fitted with a one-lumen working channel are presented. This new technique of `Transnasal Tubo-Tympanoscopy' (TTT) only needs local anesthesia, normally is performed on an outpatient basis, and is indicated for the diagnosis of any disturbances of the sound conducting apparatus (ear drum and ossicular chain) like chronic otitis media and oto-sclerosis and of those sensorineural hearing disorders on which -- until today -- only the traditional surgical tympanoscopy could provide morphological information on the pathogenesis of the hearing loss, e.g., on assumed round window ruptures. By this minimal invasive and minimal traumatizing method pathological alterations of the ossicular chain as well as obstructions in the cartilaginous and the osseous part of the Eustachian tube can be directly visualized.
Immunologic Inhibition of Ultraviolet Radiation-Induced Tumor Suppressor Cell Activity (1984)

Long-term exposure of C3H mice to ultraviolet radiation resulted in the formation of suppressor T cells that recognize ultraviolet radiation-induced regressor skin cancers as a class before the appearance of overt tumors. Administration of monoclonal antibodies to the product of the I-Jk subregion of the major histocompatibility complex or low doses of cyclophosphamide in vivo inhibited the development or activity of these cells. This activity of the monoclonal antibody was eliminated by adsorption on B10.BR (I-Jk) but not B10.D2 (I-Jd) splenocytes. These findings provide evidence that elements expressing the I-J determinant are important in regulating the host response prior to the overt development of ultraviolet radiation-induced skin cancers and suggest novel therapeutic approaches to malignancies or other diseases involving suppressor T cells in their pathogenesis.
J/ψElliptic Flow in Pb-Pb Collisions atsNN=2.76  TeV (2013)

We report on the first measurement of inclusive J/ψ elliptic flow v2 in heavy-ion collisions at the LHC. The measurement is performed with the ALICE detector in Pb-Pb collisions at √(s(NN))=2.76 TeV in the rapidity range 2.5<y<4.0. The dependence of the J/ψ v2 on the collision centrality and on the J/ψ transverse momentum is studied in the range 0≤p(T)<10 GeV/c. For semicentral Pb-Pb collisions at √(s(NN))=2.76 TeV, an indication of nonzero v2 is observed with a largest measured value of v2=0.116±0.046(stat)±0.029(syst) for J/ψ in the transverse momentum range 2≤p(T)<4 GeV/c. The elliptic flow measurement complements the previously reported ALICE results on the inclusive J/ψ nuclear modification factor and favors the scenario of a significant fraction of J/ψ production from charm quarks in a deconfined partonic phase.
An immunodominant minor histocompatibility alloantigen that initiates corneal allograft rejection1 (2003)

There are minor H alloantigens that terminate ocular immune privilege and initiate corneal allograft rejection. These minor H alloantigens are more immunogenic when expressed in corneal tissue than when they are expressed in skin allografts.
The HiSIM compact models of high-voltage/power semiconductor devices for circuit simulation (2014)

We review the high-voltage/power device models of the HiSIM family of compact models for circuit simulation. The HiSIM-HV model for integrated lateral high-voltage MOSFETs as e. g. the lateral double-diffused MOS (LDMOS) and its extensions to vertical power-device structures like UMOS or SJ-MOS are given a special focus. Additionally extensions to reverse/forward recovery effects and advanced materials like SiC are presented.
Inner ear‐specific autoantibodies (1993)

The sera of patients with idiopathic sensorineural hearing loss (SNHL) were examined, using qualitative immunoblotting (Western blotting), for the presence of inner ear (IE)-specific autoantibodies. The water-soluble extracts and the sodium dodecyl sulfate-soluble extracts were prepared as the antigens from bovine IE tissues and several other organs in order to determine the specificity of autoantibodies in their sera to the IE. Some patients (n = 46) tested had autoantibodies that reacted with 68-, 62-, 55-, 50-, or 47-kd antigenic determinants found in all tissues, while others (n = 13) showed IE-specific autoantibodies which reacted with 220-, 60-, 58-, 33-35-, or 32-kd determinants. The presence of these autoantibodies from patients with progressive SNHL may have important implications with regard to their etiology and possibly their sensitivity to therapeutic intervention. It is now necessary to purify these IE-specific antigens and determine their clinical usefulness.
Effects of long-termin vitroincubation of human spermatozoa: functional parameters and catalase effect (2001)

Prolonged incubation of human spermatozoa can have deleterious effects on sperm function. The aim of this paper was to describe the effects of a prolonged in vitro incubation, under similar conditions to those employed in human assisted reproduction, on various sperm functional parameters, and to investigate the effect of an antioxidant (catalase) on this system. Freshly collected ejaculates from 20 healthy donors were studied. Samples were divided into two aliquots: the first was incubated with Ham's F10 containing 3.5% HAS, and the second was incubated in the same medium plus catalase (100 units ml-1). All experiments were carried out with spermatozoa isolated using the swim-up technique. Spermatozoa recovered from the supernatant after 1 h (T1) of incubation in 5% CO2 in air at 37 degrees C, and after 5 h (T6), 23 h (T24) and 47 h (T48), were evaluated for concentration, motion parameters including hyperactivation (computer-assisted analysis), viability, ATP concentration, reactive oxygen species (ROS) generation, DNA integrity (acridine orange), and acrosome reaction (AR). The major alteration observed in sperm function during the prolonged in vitro incubation was a reduction in the number of motile spermatozoa, together with an impairment in the quality of sperm movement. ROS levels increased with the incubation time. No substantial modifications of sperm viability, chromatin condensation and AR inducibility were observed. The addition of catalase to the medium, while keeping ROS values within baseline levels, did not prevent the loss of motility or the corresponding increase in ATP.
Plasminogen Binding and Activation by Mycoplasma fermentans (2001)

The binding of plasminogen to Mycoplasma fermentans was studied by an immunoblot analysis and by a binding assay using iodine-labeled plasminogen. The binding of 125I-labeled plasminogen was inhibited by unlabeled plasminogen, lysine, and lysine analog epsilon-aminocaproic acid. Partial inhibition was obtained by a plasminogen fragment containing kringles 1 to 3 whereas almost no inhibition was observed with a fragment containing kringle 4. Scatchard analysis revealed a dual-phase interaction, one with a dissociation constant (kd) of 0.5 microM and the second with a kd of 7.5 microM. The estimated numbers of plasminogen molecules bound were calculated to be 110 and 790 per cell, respectively. Autoradiograms of ligand blots containing M. fermentans membrane proteins incubated with 125I-labeled plasminogen identified two plasminogen-binding proteins of about 32 and 55 kDa. The binding of plasminogen to M. fermentans enhances the activation of plasminogen to plasmin by the urokinase-type plasminogen activator (uPA), as monitored by measuring the breakdown of chromogenic substrate S-2251. Enhancement was more pronounced with the low-molecular-weight and the single-chain uPA variants, known to have low plasminogen activator activities. The binding of plasminogen also promotes the invasion of HeLa cells by M. fermentans. Invasion was more pronounced in the presence of uPA, suggesting that the ability of the organism to invade host cells stems not only from its potential to bind plasminogen but also from the activation of plasminogen to plasmin.
Hf-Zr interdiffusion in single crystal zircon. (1992)

Interdiffusivity of Hf and Zr in the zircon (ZrSi04)-hafnon (HfSi04) solid solution system was measured by (1) coupled annealing of synthetic hafnon and natural zircon and (2) heating of zircon crystal with a layer of hafnon epitaxially grown over the surface of zircon crystal.
Strong-Field Few-Cycle 2-µm Pulses via Kagome-Fiber Compression of Picosecond Ho:YLF Laser Pulses (2016)

We present strong-field few-cycle 2-µm pulses based on air-filled Kagome-fiber compression of 140-µJ, 3.3-ps pulses from Ho:YLF amplifier to 48 fs and 11 µJ energy.This is the first demonstration of 70-fold compression from Kagome fibers at 2 µm.
Abstract 1236: ONC201 sensitivity profiling indicates pronounced sensitivity in lymphoid, prostate, colon and brain tumors (2016)

Abstract ONC201 is a first-in-class small molecule inducer of the integrated stress response that is currently in phase II clinical trials in select advanced cancers and exhibits a benign safety profile and promising early clinical results. The efficacy of this novel agent has been demonstrated in a variety of preclinical advanced cancer models in multiple indications with an exceptional safety profile that has translated well to the clinic. To better characterize the differential sensitivity of tumor cells to ONC201 we performed in vitro efficacy assays in the Genomic of Drug Sensitivity in Cancer collection of cell lines (&amp;gt;1,000 cell lines), in addition to profiling in NCI60 panel. Sensitivity profiling was assessed by cell viability assays using dose responses curves at concentrations up to 20uM and at 72 hours post-treatment. Ranking the sensitivity dataset by tumor type revealed that lymphoma, colon, prostate and brain cancers were highly responsive to ONC201. The strongest predictor of sensitivity to ONC201 was tumor type, with lymphoma being the strong predictor. Within lymphomas, diffuse histiocytic lymphoma was the most sensitive subtype. Mutations that are frequent in lymphoma were not associated with ONC201 sensitivity. Recent mechanistic studies have implicated the ER stress response in the early stage mechanism of ONC201 that triggers its downstream antitumor effects. The mutation-agnostic efficacy that is pronounced in lymphomas, prostate, colon, and brain cancers is in accordance with the recent findings that ONC201 induces the integrated stress response through a novel target to trigger is downstream late apoptotic effects. Cancers of the prostate and brain (glioblastoma multiforme) are among some of the solid tumors that are susceptible to induction of apoptosis via the integrated stress response, as they have relatively high basal activation of this pathway due to ER stress. Confirmatory studies revealed that brain cancer cell lines and ex vivo samples indeed possess pronounced sensitivity with nanomolar GI50s, unlike most other tumor types, which is particularly encouraging given the systemic concentrations observed in the first-in-man study. Together, these studies suggest specific advanced cancer indications, such as non-Hodgkin's lymphoma, multiple myeloma, and glioblastoma as promising lead indications for this novel agent that are being evaluated in phase II clinical trials. Citation Format: Rohinton Tarapore, Mathew Garnett, Ultan McDermott, Cyril Benes, Joshua Allen. ONC201 sensitivity profiling indicates pronounced sensitivity in lymphoid, prostate, colon and brain tumors. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 1236.
Discovery of a Highly Potent and Broadly Effective Epidermal Growth Factor Receptor and HER2 Exon 20 Insertion Mutant Inhibitor (2018)

Exon 20 insertion (Ex20Ins) mutations are the third most prevalent epidermal growth factor receptor (EGFR) activating mutation and the most prevalent HER2 mutation in non-small cell lung cancer (NSCLC). Novel therapeutics for the patients with Ex20Ins mutations are urgently needed, due to their poor responses to the currently approved EGFR and HER2 inhibitors. Here we report the discovery of highly potent and broadly effective EGFR and HER2 Ex20Ins mutant inhibitors. The co-crystal structure of compound 1 b in complex with wild type EGFR clearly revealed an additional hydrophobic interaction of 4-fluorobenzene ring within a deep hydrophobic pocket, which has not been widely exploited in the development of EGFR and HER2 inhibitors. As compared with afatinib, compound 1 a exhibited superior inhibition of proliferation and signaling pathways in Ba/F3 cells harboring either EGFR or HER2 Ex20Ins mutations, and in the EGFR P772_H773insPNP patient-derived lung cancer cell line DFCI127. Our study identifies promising strategies for development of EGFR and HER2 Ex20Ins mutant inhibitors.
Indoor Location Competition 2.0 Dataset (2023)

This is the dataset of our Mobicom 2023 paper titled "The Wisdom of 1,170 Teams: Lessons and Experiences from a Large Indoor Localization Competition". We organized an indoor location competition in 2021. 1446 contestants from more than 60 countries making up 1170 teams participated in this unique global event. In this competition, a first-of-its-kind large-scale indoor location benchmark dataset (60 GB) was released. The dataset for this competition consists of dense indoor signatures of WiFi, geomagnetic field, iBeacons etc. as well as ground truth locations collected from hundreds of buildings in Chinese cities. Here we upload a sample data to Zenodo, and the whole dataset can be found at https://www.kaggle.com/c/indoor-location-navigation.
ChemInform Abstract: Synthesis and Biological Evaluation of N‐(7‐Indolyl)‐3‐pyridinesulfonamide Derivatives as Potent Antitumor Agents. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Hypertensive retinopathy and cardiovascular disease risk: 6 population-based cohorts meta-analysis (2023)

In persons with hypertension, both mild and moderate hypertensive retinopathy were associated with higher CVD risk.
ZUPT-aided INS Bypassing Stance Phase Detection by Using Foot-Instability-Based Adaptive Covariance (2021)

&lt;p&gt;In this paper, we propose a Foot-Instability-Based Adaptive (FIBA) covariance to dynamically adjust the covariance matrix for the pseudo-zero-velocity measurements in the Zero velocity UPdaTe (ZUPT)-aided Inertial Navigation Systems (INS). The proposed ZUPT-aided INS using the FIBA covariance is implemented in an Adaptive Extended Kalman Filter (AEKF) framework, where the measurement covariance matrix is updated in each iteration according to the FIBA covariance. The FIBA covariance is designed to have a very high value during the swing phases in a gait cycle, and the value significantly decreases during the stance phases. As a result, the proposed method eliminates a need to use a binary stance phase detector in implementation of the ZUPT-aided INS. Two series of indoor pedestrian navigation experiments were conducted to investigate the navigation performance of the algorithm. In the first series of experiments, which included cases of walking and running, localization solutions produced by the system using the FIBA covariance demonstrated 36% and 64% improvements in navigation accuracy along the horizontal and vertical directions, respectively. In the second series of experiments, which included a pedestrian walking on different indoor terrains, such as flat planes, stairs, and ramps, the navigation accuracy of the system using the FIBA covariance reduced horizontal and vertical position errors by 12% and 45%, respectively, as compared to the conventional ZUPT-aided INS.&lt;/p&gt;
A tiny lensless position sensing device for the tracking of active markers (2013)

International audience
Stimulation of Tryptophanase Synthesis in Escherichia coli by Cyclic 3′,5′-Adenosine Monophosphate (1969)

Abstract Cyclic 3',5'-AMP stimulates the rate of tryptophanase synthesis in Escherichia coli treated with tris(hydroxymethyl)aminomethane and ethylenediaminetetraacetic acid and induced with tryptophan. A maximal effect occurs at 4 x 10-4 m cyclic 3',5'-AMP and a half-maximal response at 1.5 x 10-4 m. The action of cyclic 3',5'-AMP is specific for tryptophanase since the over-all rate of protein and RNA synthesis and the synthesis of the biosynthetic enzyme tryptophan synthetase are unaffected. One site of cyclic 3',5'-AMP action appears to be after the transcription of DNA into messenger RNA since increased enzyme synthesis is observed in induced cells in which cyclic 3',5'-AMP is added after messenger RNA synthesis is arrested by actinomycin D, proflavine, or inducer removal. The half-life of the messenger RNA for tryptophanase is 3 min and is unaffected by cyclic 3',5'-AMP. Cyclic 3',5'-AMP also fails to stimulate the conversion of tryptophanase precursor into active enzyme. Thus cyclic 3',5'-AMP appears to act at the level of the polysome to increase the rate of polypeptide synthesis.
Atom efficient synthesis of pyrimidine and purine nucleosides by ball milling (2015)

A range of nucleosides have been synthesised utilising a solventless approach to Vorbrüggen glycosylations aided by mechanochemistry.
Optimum design of a single-phase Power Pulsating Buffer (PPB) with PCB-integrated inductor technologies (2018)

This paper presents the design procedure for a Buck Power Pulsating Buffer, aimed at optimising the power density of a single phase AC/DC converter. It compares different technologies for the buffer capacitor and for the inductor with printed-circuit board (PCB) integration in mind. As ceramic capacitors are considered (X6S and Ceralink technologies), a non-linear model was developed for the capacitance and ESR variations. This differs from existing literature because film capacitors are usually used and simple models are appropriate for such technologies. Two low-cost, highly integrated inductor technologies are compared. Results allow a fair comparison of these different capacitor and inductor technologies, and it found that the design based on X6S capacitors and planar inductors offers the smaller volume and best efficiency. Moreover, the optimisation procedure favours an original approach, where the converter operates at zero voltage switching (ZVS) along the entire mains period at fixed switching frequency.
Conception sismique des murs de refend couplés (1997)

The paper presents the different steps involved in the design of coupled walls located in seismic regions. Three aspects have been considered : (i) a review of the relevant specifications of the Canadian standards and National Building Code of Canada governing the design of coupled walls, (ii) a proposal for a classification method that avoids the need for any analysis during the calculation of the degree of coupling, and (iii) the development of a strategy for a step-by-step design, in compliance with the National Building Code of Canada and the new CSA/CAN3-A23.3-M94 standard for the design of concrete structures. The new National Building Code of Canada classifies henceforth ductile coupled walls as a function of their degree of coupling in two categories : (i) ductile partially coupled walls and (ii) fully ductile coupled walls. In this regard, this paper presents a method to evaluate the degree of coupling without need for analysis, which is particularly advantageous during predesign. This is followed by a step-by-step presentation of the design stages of partially as well as fully coupled walls. A design example is fully treated thereafter. The paper is intended for the practicing engineer and is motivated by the new aspects introduced in the new standard and the difficulties encountered by designers facing the study of systems including coupled walls.
A framework for resilient remote monitoring (2014)

Today's activities in cyber space are more connected than ever before, driven by the ability to dynamically interact and share information with a changing set of partners over a wide variety of networks. To support dynamic sharing, computer systems and network are stood up on a continuous basis to support changing mission critical functionality. However, configuration of these systems remains a manual activity, with misconfigurations staying undetected for extended periods, unneeded systems remaining in place long after they are needed, and systems not getting updated to include the latest protections against vulnerabilities. This environment provides a rich environment for targeted cyber attacks that remain undetected for weeks to months and pose a serious national security threat. To counter this threat, technologies have started to emerge to provide continuous monitoring across any network-attached device for the purpose of increasing resiliency by virtue of identifying and then mitigating targeted attacks. For these technologies to be effective, it is of utmost importance to avoid any inadvertent increase in the attack surface of the monitored system. This paper describes the security architecture of Gestalt, a next-generation cyber information management platform that aims to increase resiliency by providing ready and secure access to granular cyber event data available across a network. Gestalt's federated monitoring architecture is based on the principles of strong isolation, least-privilege policies, defense-in-depth, crypto-strong authentication and encryption, and self-regeneration. Remote monitoring functionality is achieved through an orchestrated workflow across a distributed set of components, linked via a specialized secure communication protocol, that together enable unified access to cyber observables in a secure and resilient way.