gebhart/patrepeval huggingface dataset:
O1‐05‐08: Targeting the APP secretases improves learning and reduces hippocampal cell death following brain injury (2009)

TBI is a disease process, with an initial injury which induces biochemical and cellular changes that contribute to continuing neuronal damage and death over time. This continuing damage is known as secondary injury, and multiple apoptotic and inflammatory pathways are activated as part of this process. TBI is a significant risk factor for the development of Alzheimer's disease, and studies show that 30% of TBI fatalities have Aβ deposits. Not only does Aβ accumulate after TBI, but so the APP enzymes responsible for Aβ production: BACE1 and the γ-secretase complex protein presenilin-1 (PS-1). In order to understand the role of these secretases in brain trauma, we targeted β- and γ-secretases with genetic knockout and pharmacological inhibition in an experimental model of TBI. Mice were exposed to the controlled cortical impact model of TBI. In this model, a 4 mm craniotomy is performed on the left parietal bone. The impounder tip of the pneumatic injury device impacts the cortical surface at a moderate level. This model induces both necrotic and apoptotic cell death, causing a brain lesion and development of behavioral deficits. Exposure to TBI resulted in accumulation of endogenous mouse Aβ within 1 day, with Aβ levels increased by almost 120% at day 3 before normalizing by day 7. As expected the accumulation of Aβ corresponded with increased protein levels of APP, BACE1, and PS-1. We found that BACE1-/- and DAPT-treated mice had reduced motor deficits and decreased spatial learning impairments following trauma when compared to BACE+/+ and vehicle-treated mice. T2-weighted MRI analysis and histological assessment revealed that BACE-/- and DAPT treatment spared large areas of cortex and subcortical white matter tracks, reduced hippocampal neuron loss and significantly reduced lesion size by 30% and 70% respectively. These data demonstrate that the APP secretases are involved in the onset of secondary injury following TBI, and that blocking either β- or γ-secretases can ameliorate motor and cognitive deficits and reduce cell loss following experimental TBI. Thus, modulation of APP secretases may provide novel therapeutic targets for the treatment of TBI.
Synthesis and resolution of (.+-.)-7-chloro-8-hydroxy-1-(3'-iodophenyl)-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine (TISCH): a high affinity and selective iodinated ligand for CNS D1 dopamine receptor [Erratum to document cited in CA114(13):122017d] (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and resolution of (.+-.)-7-chloro-8-hydroxy-1-(3'-iodophenyl)-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine (TISCH): a high affinity and selective iodinated ligand for CNS D1 dopamine receptor [Erratum to document cited in CA114(13):122017d]Sumalee Chumpradit, Mei Pung Kung, Jeffrey J. Billings, and Hank F. KungCite this: J. Med. Chem. 1991, 34, 12, 3405Publication Date (Print):December 1, 1991Publication History Published online1 May 2002Published inissue 1 December 1991https://pubs.acs.org/doi/10.1021/jm00116a013https://doi.org/10.1021/jm00116a013research-articleACS PublicationsRequest reuse permissionsArticle Views68Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Rosiglitazone elicits in vitro relaxation in airways and precision cut lung slices from a mouse model of chronic allergic airways disease (2015)

Rosiglitazone (RGZ), a peroxisome proliferator-activated receptor-γ (PPARγ) ligand, is a novel dilator of small airways in mouse precision cut lung slices (PCLS). In this study, relaxation to RGZ and β-adrenoceptor agonists were compared in trachea from naïve mice and guinea pigs and trachea and PCLS from a mouse model of chronic allergic airways disease (AAD). Airways were precontracted with methacholine before addition of PPARγ ligands [RGZ, ciglitazone (CGZ), or 15-deoxy-(Δ12,14)-prostaglandin J2 (15-deoxy-PGJ2)] or β-adrenoceptor agonists (isoprenaline and salbutamol). The effects of T0070907 and GW9662 (PPARγ antagonists) or epithelial removal on relaxation were assessed. Changes in force of trachea and lumen area in PCLS were measured using preparations from saline-challenged mice and mice sensitized (days 0 and 14) and challenged with ovalbumin (3 times/wk, 6 wk). RGZ and CGZ elicited complete relaxation with greater efficacy than β-adrenoceptor agonists in mouse airways but not guinea pig trachea, while 15-deoxy-PGJ2 did not mediate bronchodilation. Relaxation to RGZ was not prevented by T0070907 or GW9662 or by epithelial removal. RGZ-induced relaxation was preserved in the trachea and increased in PCLS after ovalbumin-challenge. Although RGZ was less potent than β-adrenoceptor agonists, its effects were additive with salbutamol and isoprenaline and only RGZ maintained potency and full efficacy in maximally contracted airways or after allergen challenge. Acute PPARγ-independent, epithelial-independent airway relaxation to RGZ is resistant to functional antagonism and maintained in both trachea and PCLS from a model of chronic AAD. These novel efficacious actions of RGZ support its therapeutic potential in asthma when responsiveness to β-adrenoceptor agonists is limited.
Irrational methods suggest indecomposability and emergence (2023)

Abstract This paper offers a practical argument for metaphysical emergence. The main message is that the growing reliance on so-called irrational scientific methods provides evidence that objects of science are indecomposable and as such, are better described by metaphysical emergence as opposed to the prevalent reductionistic metaphysics. I show that a potential counterargument that science will eventually reduce everything to physics has little weight given where science is heading with its current methodological trend. I substantiate my arguments by detailed examples from biological engineering, but the conclusions are extendable beyond that discipline.
Vasopressor Infusion During Prone Spine Surgery and Acute Renal Injury: A Retrospective Cohort Analysis (2019)

Clinicians should not avoid typical perioperative doses of vasopressors for fear of promoting kidney injury. Tolerating hypotension to avoid vasopressor use would probably be a poor strategy.
AI-Assisted Discovery of Quantitative and Formal Models in Social Science (2022)

In social science, formal and quantitative models, such as ones describing economic growth and collective action, are used to formulate mechanistic explanations, provide predictions, and uncover questions about observed phenomena. Here, we demonstrate the use of a machine learning system to aid the discovery of symbolic models that capture nonlinear and dynamical relationships in social science datasets. By extending neuro-symbolic methods to find compact functions and differential equations in noisy and longitudinal data, we show that our system can be used to discover interpretable models from real-world data in economics and sociology. Augmenting existing workflows with symbolic regression can help uncover novel relationships and explore counterfactual models during the scientific process. We propose that this AI-assisted framework can bridge parametric and non-parametric models commonly employed in social science research by systematically exploring the space of nonlinear models and enabling fine-grained control over expressivity and interpretability.
Answers to Comments/Questions of Referee2 (2016)

Q-However, the organization and motivation needs to be made clearer, both in the introduction and in the atmospheric implications. Both sections read like a "data dump" with little explanation to identify the key discrepancies or limitations in the literature. Why are the authors conducting this study, 20+ years after some of the initial studies were conducted? A-Referee 2 raises an important point: Why unfold the glory of heterogeneous chemistry once more (or once and for all?) after 20 years of (waning) interest? It may have C1
Experimental Identification and Modeling of Dynamic Tire Friction Potential on Slippery Surfaces (2007)

It has been demonstrated previously that the tire-ice friction is characterized by a significant dynamic potential (DTFP) for abrupt transients of the wheel torque. The analysis has shown that the DTFP is predominantly caused by the bristle dwell time, which is defined as the time that the tire bristles (the tire elements) dwell in the tire-road contact patch. The effect is explained by the tire ability to imprint into the ice. Regardless of whether the tire is at standstill or it rotates, the bristles dwell for some time in the contact patch and adhere to fixed road points, thus causing the temporary imprinting effect. The higher the wheel center speed, the shorter the bristle dwell time, and the lower the DTFP. The paper deals with modeling of the Dynamic Tire Friction Potential (DTFP) and further experimental investigation for various road conditions and operating modes. The model is based on the LuGre tire friction model extended with the DTFP effect. The extension relies on the hypothesis that the DTFP is caused by the bristle dwell time effect. The model is parameterized based on the experimental data for tire force vs. slip static curve and DTFP vs. average bristle dwell time curve. The accuracy of the model is proven by experimental validation for various operating conditions. The experimental investigation is further extended for snow surfaces, and also ice surfaces with various ice condition/temperature are considered. The paper also presents an experimental analysis of a sliding contact based on locking tire on ice surface.
Nanoengineered optical resonance sensor for composite material refractive-index measurements (2009)

We present an optical resonance sensor capable of measurement of refractive index in highly nonhomogeneous materials. Traditional optical resonance sensors fail when the size of particles is comparable with the wavelength (100 nm and larger). Our new nanoengineered design allows incorporation of a highly delocalized mode into a resonance structure. The sensing depth of the device was measured to be 1 mum, the largest reported in the literature as far as we know, with a quality factor of 500. We demonstrate two applications.
Electrochemical and Surface Properties of Solid-Supported, Mobile Phospholipid Bilayers on a Polyion/Alkylthiol Layer Pair Used for Detection of Antimicrobial Peptide Insertion (2002)

Successive layer properties and peptide insertion in an assembly of supported mobile phospholipid bilayers on polyion/alkylthiol layer pairs were investigated in a combined optical, electrochemical, and surface topography study using surface plasmon resonance (SPR), cyclic voltammetry (CV), and atomic force microscopy (AFM). The use of a long-chain alkylthiol in this assembly was too insulating, and thus, a short-chain alkylthiol was used to probe membrane electrochemical properties. Using AFM, we found that the insulating properties of long-chain and short-chain alkylthiol layers are associated with a continuous layer and domain formation, respectively. Increased insulating properties of the supported bilayers were observed when mixtures of negatively charged and zwitterionic/neutral lipids were used. By attempting to obtain high-resolution images and make depressions in the surface using AFM, we found that this bilayer was more mobile than a bilayer composed completely of negatively charged lipid. A pore-forming antimicrobial and antiviral peptide from porcine leukocytes, protegrin-1, increased the charge transfer through the supported biomembranes. The peptide's influence on the electrochemical and topological properties of the membrane depended on the lipid compositions, although comparable amounts of the peptide were associated with the various membranes. The multilayer surface morphology is quantitatively characterized by using roughness measurements for a large set of data involving root-mean-square roughness (RMS) and power spectra density analysis (PSD). The RMS values obtained for each deposited layer reveal that the surface roughness is characterized in the nanometer and subnanometer range. Surface roughness decreased with each deposited layer in the supported bilayer system but increased with peptide adsorption to the lipid bilayer. A decreased degree of association between the lipid membrane and a mutant protegrin further demonstrates the model membrane as a sensitive tool for studying the mechanisms of antimicrobial peptides.
Studies of Frictional Properties on TN mode Alignment Film Surfaces with AFM/FFM (2009)

The surface characteristics of hybrid type twisted nematic (TN) mode alignment film (AF) were studied with atomic force microscopy (AFM) and frictional force microscopy (FFM). As a result, the contrast of friction on FFM image had changed when the probe was scanned in rubbing directions. In the friction loop, the frictional asymmetry was detected differently according to the drying temperature conditions. The difference was explained by pretilt uniformity of side chain molecules arrangement on polyimide (PI) layer surface. The measured data of surface energy and pretilt angle after liquid crystal (LC) injection couldn't represent realistic layer frictional characteristics of AF surface.
A Practical Recycle of a Ligand-Free Palladium Catalyst for Heck Reactions (2002)

Ligand-free palladium can be recovered almost quantitatively from Heck reaction mixtures by filtration after its deposition on a carrier such as silica or celite. Subsequently, it is re-activated to its original activity by adding a small amount of iodine or bromine prior to the next reaction cycle. The catalyst results in excellent yields and selectivities, even for the less reactive aryl bromides. A catalytic cycle based on anionic palladium intermediates is proposed.
Metal Gate Technology using a Dy<inf>2</inf>O<inf>3</inf> Dielectric Cap Approach for multiple-V<inf>T</inf> in NMOS FinFETs (2007)

In this work, we investigate the possibility of achieving low V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> nMOS FinFETs with single metal gate by using a dysprosium oxide (Dy <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> ) cap layer inserted between gate dielectric and metal. We determine an optimum ratio between Dy <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> and SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> gate dielectric thicknesses for low nMOS V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> with good process margin and no loss in performance and reliability.
Characterization of laser-annealed magnetic garnet films by scanning probe microscopes (1999)

A design of the waveguide magneto-optic isolator for the integrated optics requires the adjoining areas with in-plane magnetization (Faraday area) and out-of-plane magnetization (Cotton-Mouton area) in a single iron garnet film[l].
An Articulating Tool for Endoscopic Screw Delivery (2011)

This paper describes the development of an articulating endoscopic screw driver that can be used to place screws in osteosynthetic plates during thoracoscopic surgery. The device is small enough to be used with a 12 mm trocar sleeve and transmits sufficient torque to fully secure bone screws. The articulating joint enables correct screw alignment at obtuse angles, up to 60 deg from the tool axis. A novel articulating joint is presented, wherein a flexible shaft both transmits torque and actuates the joint; antagonist force is provided by a superelastic spring. Screws are secured against the driver blade during insertion with a retention mechanism that passively releases the screw once it is securely seated in the bone. The prototype has been fitted with a blade compatible with 2.0 and 2.3 mm self-drilling screws, though a different driver blade or drill bit can be easily attached. Efficacy of the tool has been demonstrated by thoracoscopically securing an osteosynthetic plate to a rib during an animal trial. This tool enables minimally invasive, thoracoscopic rib fixation.
2A1-B07 Development and Control of Master-Slave Hand with Pneumatic Actuator (2007)

Recently, robot research that coexists with people and is helpful for them is active. Such a robot needs both safety and flexibility. Then, we use a pneumatic actuator as driving source of robot hand. We originally develop a pneumatic actuator driven by low pressure because we consider that conventional pneumatic actuator is inadequate for driving source of robot hand. We develop five fingered robot hand using the pneumatic actuator. The robot hand has both safety and flexibility. We construct master-slave system to let the robot hand do the same movement as man. Next, we make a joint model that has one degree of freedom using a pneumatic actuator. We construct control system for the joint model and verify its control performance.
High‐frequency performance of AlGaN channel HEMTs with high breakdown voltage (2014)

The high‐frequency characteristics of high electron mobility transistors applying AlGaN for a channel layer (AlGaN channel HEMTs) with greater impacts of alloy disorder scattering than those in conventional HEMTs with a GaN channel layer (GaN channel HEMTs) are investigated. The obtained electron saturation velocity was 4.7 × 10 6 cm/s and the cutoff frequency was 7 GHz in the AlGaN channel HEMTs with a gate length of 1 μm. These results are promising for several gigahertz band operations of AlGaN channel HEMTs.
Application of Soft Independent Method of Class Analogy (SIMCA) in Isomer Specific Analysis of Polychlorinated Biphenyls (1985)

A principal components multivariate statistical approach (SIMCA) was evaluated and applied to interpretation of isomer specific analysis of polychlorinated biphenyls (PCBs) using both a microcomputer and a main frame computer. Capillary column gas chromatography was employed for separation and detection of 69 individual PCB isomers. Computer programs were written in ANSII MUMPS to provide a laboratory data base for data manipulation. This data base greatly assisted the analysts in calculating isomer concentrations and data management. Applications of SIMCA for quality control, classification, and estimation of the composition of multi-Aroclor mixtures are described for characterization and study of complex environmental residues.
Changing Activation Pattern of the Coronary Sinus during Ongoing Perimitral Flutter (2011)

A 68-year-old man without any structural heart disease underwent ablation of persistent atrial fibrillation in 2008 (isolation of 4 pulmonary veins and electrogram-based ablation of the posteroinferior left atrium) and 2009 (left pulmonary vein reisolation and linear ablation of the left atrial [LA] roof with demonstration of bidirectional block).Recently, he was referred for the ablation of recurrent sustained atrial tachycardia (AT) with stable cycle length of 230 ms (Fig. 1A).A steerable decapolar catheter was inserted into the coronary si-
Minimization of the kWh cost by optimization of an all-electric chain for the SEAREV Wave Energy Converter. (2008)

International audience
Supplementary Figure 1 from Tasquinimod Modulates Suppressive Myeloid Cells and Enhances Cancer Immunotherapies in Murine Models (2023)

&lt;p&gt;Supplementary Figure 1. Survivin peptide vaccine, SurVaxM, induced antigen-specific CD8 effector cells in the tumor bearing animals.&lt;/p&gt;
Golden Exosomes Selectively Target Brain Pathologies in Neurodegenerative and Neurodevelopmental Disorders (2019)

Exosomes, nanovesicles that are secreted by different cell types, enable intercellular communication at local or distant sites. Alhough they have been found to cross the blood brain barrier, their migration and homing abilities within the brain remain unstudied. We have recently developed a method for longitudinal and quantitative in vivo neuroimaging of exosomes based on the superior visualization abilities of classical X-ray computed tomography (CT), combined with gold nanoparticles as labeling agents. Here, we used this technique to track the migration and homing patterns of intranasally administrated exosomes derived from bone marrow mesenchymal stem cells (MSC-exo) in different brain pathologies, including stroke, autism, Parkinson's disease, and Alzheimer's disease. We found that MSC-exo specifically targeted and accumulated in pathologically relevant murine models brains regions up to 96 h post administration, while in healthy controls they showed a diffuse migration pattern and clearance by 24 h. The neuro-inflammatory signal in pathological brains was highly correlated with MSC-exo accumulation, suggesting that the homing mechanism is inflammatory-driven. In addition, MSC-exo were selectively uptaken by neuronal cells, but not glial cells, in the pathological regions. Taken together, these findings can significantly promote the application of exosomes for therapy and targeted drug delivery in various brain pathologies.
Supplementary Figure S4 from Preclinical Activity of SAR408701: A Novel Anti-CEACAM5–maytansinoid Antibody–drug Conjugate for the Treatment of CEACAM5-positive Epithelial Tumors (2023)

&lt;p&gt;Supplementary Figure S4&lt;/p&gt;
Aminophylline suppresses stress-induced visceral hypersensitivity and defecation in irritable bowel syndrome (2017)

Pharmacological therapy for irritable bowel syndrome (IBS) has not been established. In order to find candidate drugs for IBS with diarrhea (IBS-D), we screened a compound library of drugs clinically used for their ability to prevent stress-induced defecation and visceral hypersensitivity in rats. We selected the bronchodilator aminophylline from this library. Using a specific inhibitor for each subtype of adenosine receptors (ARs) and phosphodiesterases (PDEs), we found that both A<sub>2B</sub>ARs and PDE4 are probably mediated the inhibitory effect of aminophylline on wrap restraint stress (WRS)-induced defecation. Aminophylline suppressed maternal separation- and acetic acid administration-induced visceral hypersensitivity to colorectal distension (CRD), which was mediated by both A<sub>2A</sub>ARs and A<sub>2B</sub>ARs. We propose that aminophylline is a candidate drug for IBS-D because of its efficacy in both of stress-induced defecation and visceral hypersensitivity, as we observed here, and because it is clinically safe.
Panobinostat consolidation in patients with Hodgkin lymphoma at risk for relapse after high dose chemotherapy and autologous stem cell transplant: final results after early trial discontinuation (2016)

High-dose chemotherapy with autologous stem cell transplant (ASCT) is the treatment of choice for Hodgkin lymphoma (HL) patients suffering from relapse or progression after first line therapy.[1] H...