gebhart/patrepeval huggingface dataset:
Housefly Maggot Meal (Magmeal): An Emerging Substitute of Fishmeal in Tilapia Diets (2006)

Several feed ingredients have been investigated in an attempt to substitute fishmeal in the diets of fish and livestock. These include both animal protein and plant protein sources. Unfortunately attempts to use these ingredients for complete replacement of the fishmeal component in tilapia diets have not entirely been successful. A major reason is the suboptimal content of essential amino acids in the diets especially methionine. Based on cost effectiveness, availability, crude protein content and amino acid profile, magmeal seem to be a candidate for replacement of fishmeal in fish diets. In this study, seven test diets (36 % crude protein, dry matter) formulated by replacing fishmeal with magmeal were fed to triplicate groups of fifteen fingerlings (initial average weight 2.0±0.1g) for 56 days. Results obtained from growth parameters, protein utilisation, stress indicators and haematological parameters revealed no significant difference among all feeding groups. The observation suggests that magmeal can completely replace fishmeal in the diet of Tilapia Oreochromis niloticus fingerling and can meet the nutrient requirements of this species.
Shoulder arthroplasty in patients with upper extremity lymphedema may result in transient or permanent lymphedema worsening (2019)

Shoulder arthroplasty for an upper extremity with lymphedema provides substantial improvements in pain and motion; however, infection is a concerning complication. Fifty percent of the patients will experience worsening of their lymphedema and in 20% worsening may be permanent.
Structural Activity Relationship Study on Dual PLK1 /BRD4 Inhibitor, BI- 2536 (2020)

Polo-like kinase 1 (PLK1) and BRD4 are two different therapeutic targets in cancer drug discovery. Recently it has been reported that PLK1 inhibitor, BI-2536, is also a potent inhibitor of BRD4. The simultaneous inhibition of PLK1 and BRD4 by a single drug molecule is interesting because this could lead to the development of effective therapeutic strategy for different types of disease conditions in which PLK1 and BRD4 are implicated. Structural activity relationship studies has been carried out on BI-2536 to generate analogs with enhanced dual inhibitory activity against BRD4 and PLK1 as well as to render the molecule selective to one target over the other. UMB101 and 160 have been found to exhibit enhanced dual inhibitory activity with selectivity fold of less than 30, UMB160 being the most potent dual-kinase bromodomain inhibitor (BRD4 IC50 = 28 nM, PLK1 IC50 = 40 nM). UMB131 was found to be the most selective PLK1 inhibitor over BRD4.
The new age of MOFs and of their porous-related solids (2017)

Guest editors Guillaume Maurin, Christian Serre, Andrew Cooper and Gérard Férey introduce the Metal–Organic Frameworks and Porous Polymers – Current and Future Challenges issue of <italic>Chemical Society Reviews</italic>.
Fourier domain beamforming for medical ultrasound (2013)

Sonography techniques use multiple transducer elements for tissue visualization. Signals detected at each element are sampled prior to digital beamforming. The required sampling rates are up to 4 times the Nyquist rate of the signal and result in considerable amount of data, that needs to be stored and processed. A developed technique, based on the finite rate of innovation model, compressed sensing (CS) and Xampling ideas, allows to reduce the number of samples needed to reconstruct an image comprised of strong reflectors. A significant drawback of this method is its inability to treat speckle, which is of significant importance in medical imaging. Here we build on previous work and show explicitly how to perform beamforming in the Fourier domain. Beamforming in frequency exploits the low bandwidth of the beamformed signal and allows to bypass the oversampling dictated by digital implementation of beamforming in time. We show that this allows to obtain the same beamformed image as in standard beamforming but from far fewer samples. Finally, we present an analysis based CS-technique that allows for further reduction in sampling rate, using only a portion of the beamformed signal's bandwidth, namely, sampling the signal at sub-Nyquist rates. We demonstrate our methods on in vivo cardiac ultrasound data and show that reductions up to 1/25 over standard beamforming rates are possible.
Select, Label, and Mix: Learning Discriminative Invariant Feature Representations for Partial Domain Adaptation (2023)

Partial domain adaptation which assumes that the unknown target label space is a subset of the source label space has attracted much attention in computer vision. Despite recent progress, existing methods often suffer from three key problems: negative transfer, lack of discriminability, and domain invariance in the latent space. To alleviate the above issues, we develop a novel ‘Select, Label, and Mix’ (SLM) framework that aims to learn discriminative invariant feature representations for partial domain adaptation. First, we present an efficient "select" module that automatically filters out the outlier source samples to avoid negative transfer while aligning distributions across both domains. Second, the "label" module iteratively trains the classifier using both the labeled source domain data and the generated pseudo-labels for the target domain to enhance the discriminability of the latent space. Finally, the "mix" module utilizes domain mixup regularization jointly with the other two modules to explore more intrinsic structures across domains leading to a domain-invariant latent space for partial domain adaptation. Extensive experiments on several benchmark datasets for partial domain adaptation demonstrate the superiority of our proposed framework over state-of-the-art methods. Project page: https://cvir.github.io/projects/slm.
Proteomic profiling of the epithelial and stromal components of matched normal and colonic carcinomas using protein microarrays (2006)

Introduction: Colorectal carcinoma does not have a single specific biomarker that can detect and predict disease behaviour. Consequently, combinations of expression markers may be useful in diagnostics and prognostics. Moreover, it is likely that the complex interaction between tumour epithelium and stroma is a key facilitator in sustaining tumor growth.
Degradation of Sliding Electrical Contacts Submerged in Silicone Fluid. (2014)

Abstract not provided.
Properties of Phosphorus-Doped Poly-SiGe Films for Microelectromechanical System Applications (2002)

P-doped SiGe films were deposited and characterized in terms of their electrical and mechanical properties. with was deposited with deposition rates of 70-100 Å/min at 450-550°C. Films with Ge content of <70% showed a very low etch rate in at 90°C; the etch rate increased significantly for higher Ge content. The resistivity of as-deposited films was about 0.1 Ω cm and could be lowered to after annealing at 900°C. The films exhibited compressive residual stress of up to 270 MPa. After annealing at >600°C, the stress changed to 100-200 MPa tensile due to the intrinsic stress relief and the thermal expansion difference between the films and the silicon substrate. In a cantilevered beam, the stress gradient through the film thickness made the as-deposited films curl downward. The stress could be reduced with appropriate annealing. With optimized deposition and annealing conditions, n-type SiGe microelectromechanical systems structures were fabricated to show feasibility of their integration with underlying multilayer poly-Si microstructures. © 2002 The Electrochemical Society. All rights reserved.
Regulation of neuroendocrine gene expression by alternative RNA processing. Colocalization of calcitonin and calcitonin gene-related peptide in thyroid C-cells. (1985)

The generation of two discrete mRNAs encoding different polypeptide products in expression of the rat calcitonin, CGRP gene provides an example of developmentally determined alternative RNA processing events in the neuroendocrine system. Both mature mRNA transcripts and their peptide products, encoding either calcitonin or calcitonin gene-related peptide (CGRP) are co-produced in identical thyroid C-cells, in a ratio of 95:1, respectively. These data suggest that the generation of the two mRNAs reflect the actions of a factor(s) dictating alternative RNA processing events.
Design of Optically Accessible, Ultra Low-Volume, Tissue Loading Bioreactor (2009)

Given mounting evidence that mechanical force is a critical parameter in the normal development and remodeling of load-bearing tissue, there is a critical need for a new class of bioreactors which can apply controlled loads/strains to tissues or engineered constructs while permitting high-powered optical accessibility. We have developed a novel bioreactor which can be mounted onto the stage of an inverted microscope which permits direct 600× observation of a perfused specimen while the specimen is held in either load or strain control. Further, the chamber has been designed to minimize free volume to reduce the cost of reagents.
On the computation of multidimensional aggregates (1999)

At the heart of all OLAP or multidimensional data analysis applications is the ability to simultaneously aggregate across many sets of dimensions. Computing multidimensional aggregates is a performance bottleneck for these applications. This paper presents fast algorithms for computing a collection of groupbys. We focus on a special case of the aggregation problem -- computation of the CUBE operator. The CUBE operator requires computing group-bys on all possible combinations of a list of attributes, and is equivalent to the union of a number of standard group-by operations. We show howthe structure of CUBE computation can be viewed in terms of a hierarchy of group-by operations. Our algorithms extend sort-based and hash-based grouping methods with several optimizations, like combining common operations across multiple group-bys, caching, and using pre-computed group-bys for computing other group-bys. Empirical evaluation shows that the resulting algorithms give much better performance compared to straightforward methods. This paper combines work done concurrently on computing the data cube by two different teams as reported in [SAG96] and [DANR96].
Probing the Surface Structural Rearrangement of Hydrogels by Sum-Frequency Generation Spectroscopy (1998)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTProbing the Surface Structural Rearrangement of Hydrogels by Sum-Frequency Generation SpectroscopyQing Chen, Dan Zhang, Gabor Somorjai, and Carolyn R. BertozziView Author Information Department of Chemistry University of California at Berkeley Materials Sciences Division Lawrence Berkeley National Laboratory Berkeley, California 94720 Cite this: J. Am. Chem. Soc. 1999, 121, 2, 446–447Publication Date (Web):December 30, 1998Publication History Received2 September 1998Published online30 December 1998Published inissue 1 January 1999https://pubs.acs.org/doi/10.1021/ja9831453https://doi.org/10.1021/ja9831453rapid-communicationACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views932Altmetric-Citations67LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Alkyls,Hydrogels,Interfaces,Nonlinear optics,Polymers Get e-Alerts
PI 3-KINASE KNOCKOUT MICE: ROLE OF p85α IN B CELL DEVELOPMENT AND PROLIFERATION (1999)

Conference Abstract| June 01 1999 PI 3-KINASE KNOCKOUT MICE: ROLE OF p85α IN B CELL DEVELOPMENT AND PROLIFERATION David A. Fruman; David A. Fruman *Division of Signal Transduction, Beth Israel Deaconess Medical Center and Department of Cell Biology, Harvard Medical School, Boston, MA, USA Search for other works by this author on: This Site PubMed Google Scholar Scott B. Snapper; Scott B. Snapper **Center for Blood Research and Children's Hospital, Boston, MA, USA Search for other works by this author on: This Site PubMed Google Scholar Claudine M. Yballe; Claudine M. Yballe *Division of Signal Transduction, Beth Israel Deaconess Medical Center and Department of Cell Biology, Harvard Medical School, Boston, MA, USA Search for other works by this author on: This Site PubMed Google Scholar Franck Mauvais-Jarvis; Franck Mauvais-Jarvis ***Joslin Diabetes Center, Boston, MA, USA Search for other works by this author on: This Site PubMed Google Scholar C. Ronald Kahn; C. Ronald Kahn ***Joslin Diabetes Center, Boston, MA, USA Search for other works by this author on: This Site PubMed Google Scholar Frederick W. Alt; Frederick W. Alt **Center for Blood Research and Children's Hospital, Boston, MA, USA Search for other works by this author on: This Site PubMed Google Scholar Lewis C. Cantley Lewis C. Cantley *Division of Signal Transduction, Beth Israel Deaconess Medical Center and Department of Cell Biology, Harvard Medical School, Boston, MA, USA Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1999) 27 (3): A73. https://doi.org/10.1042/bst027a073c Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation David A. Fruman, Scott B. Snapper, Claudine M. Yballe, Franck Mauvais-Jarvis, C. Ronald Kahn, Frederick W. Alt, Lewis C. Cantley; PI 3-KINASE KNOCKOUT MICE: ROLE OF p85α IN B CELL DEVELOPMENT AND PROLIFERATION. Biochem Soc Trans 1 June 1999; 27 (3): A73. doi: https://doi.org/10.1042/bst027a073c Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search nav search search input Search input auto suggest search filter All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1999 Biochemical Society1999 Article PDF first page preview Close Modal You do not currently have access to this content.
<title>Laser-pumped Yb:Er:glass laser</title> (1994)

There is a growing need for compact efficient and eye-safe lasers. Diode pumping is normally used to produce compact and efficient lasers when the required pumping wavelength and power are available. This paper presents the characteristics of an eye-safe Yb:Er:glass laser at 1.54 micrometers pumped by a Ti:Sapphire laser tuned between 905 and 980 nm.
Kinetics and substituent effects in the formation of zirconocene thioaldehyde complexes: .beta.-hydride elimination versus cyclometalation (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetics and substituent effects in the formation of zirconocene thioaldehyde complexes: .beta.-hydride elimination versus cyclometalationStephen L. Buchwald and Ralph B. NielsenCite this: J. Am. Chem. Soc. 1988, 110, 10, 3171–3175Publication Date (Print):May 1, 1988Publication History Published online1 May 2002Published inissue 1 May 1988https://pubs.acs.org/doi/10.1021/ja00218a027https://doi.org/10.1021/ja00218a027research-articleACS PublicationsRequest reuse permissionsArticle Views829Altmetric-Citations51LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Compression and interpolation of 3D stereoscopic and multiview video (1997)

Compression and interpolation each require, given part of an image, or part of a collection or stream of images, being able to predict other parts. Compression is achieved by transmitting part of the imagery along with instructions for predicting the rest of it; of course, the instructions are usually much shorter than the unsent data. Interpolation is just a matter of predicting part of the way between two extreme images; however, whereas in compression the original image is known at the encoder, and thus the residual can be calculated, compressed, and transmitted, in interpolation the actual intermediate image is not known, so it is not possible to improve the final image quality by adding back the residual image. Practical 3D-video compression methods typically use a system with four modules: (1) coding one of the streams (the main stream) using a conventional method (e.g., MPEG), (2) calculating the disparity map(s) between corresponding points in the main stream and the auxiliary stream(s), (3) coding the disparity maps, and (4) coding the residuals. It is natural and usually advantageous to integrate motion compensation with the disparity calculation and coding. The efficient coding and transmission of the residuals is usually the only practical way to handle occlusions, and the ultimate performance of beginning-to-end systems is usually dominated by the cost of this coding. In this paper we summarize the background principles, explain the innovative features of our implementation steps, and provide quantitative measures of component and system performance.
The London Position Statement of the World Congress of Gastroenterology on Biological Therapy for IBD With the European Crohn's and Colitis Organisation: Safety (2011)

This paper in the series from the World Congress of Gastroenterology addresses the safety and immunogenicity of biological therapy. The safety profile in randomized controlled studies of all biological agents in Crohn's disease (CD) and ulcerative colitis has been generally favorable, but a small percentage of patients experience severe side effects on biological therapy, including pneumonia, tuberculosis, lymphoma, demyelination, drug-induced lupus, or hepatotoxicity. Although there is unequivocal evidence of an increased risk of serious infection among patients with rheumatoid arthritis treated with anti-tumor necrosis factor therapy, the evidence is less clear in CD. The risk of infection may be increased by combination therapy with steroids and/or immunomodulators. There is a specific risk of the rare γ δ hepatosplenic lymphoma that appears to have a predeliction for young males on combination therapy. The α4 integrin antagonist natalizumab also carries a specific risk of progressive multifocal leucoencephalopathy and reactivation of JC virus infection. The immunogenicity of biological therapy is complex: all agents are potentially immunogenic and this can be reduced by combination with immunomodulators. This may enhance both therapeutic efficacy and the risk of infection or malignancy, so the balance of risk and benefit must be judged for individual patients.
An NQO1- and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by β-lapachone (2007)

Lung cancer is the number one cause of cancer-related deaths in the world. Patients treated with current chemotherapies for non-small-cell lung cancers (NSCLCs) have a survival rate of approximately 15% after 5 years. Novel approaches are needed to treat this disease. We show elevated NAD(P)H:quinone oxidoreductase-1 (NQO1) levels in tumors from NSCLC patients. beta-Lapachone, an effective chemotherapeutic and radiosensitizing agent, selectively killed NSCLC cells that expressed high levels of NQO1. Isogenic H596 NSCLC cells that lacked or expressed NQO1 along with A549 NSCLC cells treated with or without dicoumarol, were used to elucidate the mechanism of action and optimal therapeutic window of beta-lapachone. NSCLC cells were killed in an NQO1-dependent manner by beta-lapachone (LD50, approximately 4 microM) with a minimum 2-h exposure. Kinetically, beta-lapachone-induced cell death was characterized by the following: (i) dramatic reactive oxygen species (ROS) formation, eliciting extensive DNA damage; (ii) hyperactivation of poly(ADP-ribose)polymerase-1 (PARP-1); (iii) depletion of NAD+/ATP levels; and (iv) proteolytic cleavage of p53/PARP-1, indicating mu-calpain activation and apoptosis. Beta-lapachone-induced PARP-1 hyperactivation, nucleotide depletion, and apoptosis were blocked by 3-aminobenzamide, a PARP-1 inhibitor, and 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid acetoxymethyl ester (BAPTA-AM), a Ca2+ chelator. NQO1- cells (H596, IMR-90) or dicoumarol-exposed NQO1+ A549 cells were resistant (LD50, >40 microM) to ROS formation and all cytotoxic effects of beta-lapachone. Our data indicate that the most efficacious strategy using beta-lapachone in chemotherapy was to deliver the drug in short pulses, greatly reducing cytotoxicity to NQO1- "normal" cells. beta-Lapachone killed cells in a tumorselective manner and is indicated for use against NQO1+ NSCLC cancers.
Application of a Preformed Pd-BIDIME Precatalyst to Suzuki–Miyaura Cross-Coupling Reaction in Flow (2019)

The application of a Buchwald's third generation palladacycle containing a dihydrobenzooxaphosphole-based ligand (e.g., BIDIME) was reported in the Suzuki cross-coupling reaction. Using flow technology, high yield and reproducible Suzuki cross-coupling reaction for one of our key intermediates was achieved with Pd loadings as low as 0.5 mol %. This continuous flow approach overcomes catalyst deactivation and scale dependence issues that can be a problem in some traditional batch-mode operations and responds to the challenge of improving process greenness.