gebhart/patrepeval huggingface dataset:
Function-Oriented Synthesis: Design, Synthesis, and Evaluation of Highly Simplified Bryostatin Analogues (2020)

Using a function-oriented synthesis strategy, we designed, synthesized, and evaluated the simplest bryostatin 1 analogues reported to date, in which bryostatin's A- and B-rings are replaced by a glutarate linker. These analogues, one without and one with a C26-methyl group, exhibit remarkably different protein kinase C (PKC) isoform affinities. The former exhibited bryostatin-like binding to several PKC isoforms with <i>K</i><sub>i</sub>'s < 5 nM, while the latter exhibited PKC affinities that were up to ∼180-fold less potent. The analogue with bryostatin-like PKC affinities also exhibited bryostatin-like PKC translocation kinetics <i>in vitro</i>, indicating rapid cell permeation and engagement of its PKC target. This study exemplifies the power of function-oriented synthesis in reducing structural complexity by activity-informed design, thus enhancing synthetic accessibility, while still maintaining function (biological activity), collectively providing new leads for addressing the growing list of therapeutic indications exhibited by PKC modulators.
Self-Assembly of n-Alkanethiolate Monolayers on Silver Nanostructures: Determination of the Apparent Thickness of the Monolayer by Scanning Tunneling Microscopy (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSelf-Assembly of n-Alkanethiolate Monolayers on Silver Nanostructures: Determination of the Apparent Thickness of the Monolayer by Scanning Tunneling MicroscopyWenjie Li, Jorma A. Virtanen, and Reginald M. PennerCite this: J. Phys. Chem. 1994, 98, 45, 11751–11755Publication Date (Print):November 1, 1994Publication History Published online1 May 2002Published inissue 1 November 1994https://pubs.acs.org/doi/10.1021/j100096a020https://doi.org/10.1021/j100096a020research-articleACS PublicationsRequest reuse permissionsArticle Views273Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
In-Band Spectrum Sensing in IEEE 802.22 WRANs for Incumbent Protection (2010)

In cognitive radios, in-band spectrum sensing is essential for the protection of legacy spectrum users, enabling secondary users to vacate channels immediately upon detection of primary users. For in-band sensing, it is important to meet detectability requirements, such as the maximum allowed detection latency and the probability of misdetection and false alarm. In this paper, we propose key techniques for efficient in-band sensing. We first advocate the use of clustered sensor networks, and propose a periodic in-band sensing algorithm that optimizes sensing period and sensing time to meet the detectability requirements while minimizing sensing overhead. The scheme also determines the better of energy or feature detection incurring less sensing overhead at each SNR level, and derives the threshold aRSS <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">threshold</sub> on the average received signal strength of a primary signal above which energy detection is preferred to feature detection. We consider two key factors affecting aRSS <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">threshold</sub> noise uncertainty and inter-CRN interference. aRSS <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">threshold</sub> appears to lie between -114.6 dBm and -109.9 dBm with noise uncertainty ranging from 0.5 dB to 2 dB, and between -112.9 dBm and -110.5 dBm with 1-6 interfering CRNs. We also investigate how strict the detection requirement must be for efficient reuse of idle channels without incurring unnecessary channel switches due to false detection of primaries.
Long-wavelength vertical-cavity lasers (2002)

In this paper we summarize the latest developments in long-wavelength vertical-cavity lasers fabricated by wafer fusion. Record room-temperature pulsed performance was achieved at both 1.3 and 1.52 /spl mu/m wavelengths using novel vertical-cavity laser structures that utilize InP/InGaAsP active layers and AlAs/GaAs quarter-wave mirrors.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Unveiling the Biosynthetic Pathway of the Ribosomally Synthesized and Post‐translationally Modified Peptide Ustiloxin B in Filamentous Fungi (2016)

Abstract The biosynthetic machinery of the first fungal ribosomally synthesized and post‐translationally modified peptide (RiPP) ustiloxin B was elucidated through a series of gene inactivation and heterologous expression studies. The results confirmed an essential requirement for novel oxidases possessing the DUF3328 motif for macrocyclization, and highly unique side‐chain modifications by three oxidases (UstCF1F2) and a pyridoxal 5′‐phosphate (PLP)‐dependent enzyme (UstD). These findings provide new insight into the expression of the RiPP gene clusters found in various fungi.
Hydride shift in substituted phenyl glyoxals: Interpretation of experimental rate data using electronic structure and variational transition state theory calculations (2001)

Experimental rate data for hydride transfer in some p-substituted phenyl glyoxals in 80: 20 dioxan:water are presented including kinetic hydrogen isotope effects. The roles of different substituents are discussed using electronic structure calculations of the potential energy surfaces at the SM5.4/PM3 level together with calculations employing variational transition state theory and multidimensional tunneling. p-NO2 substitution has the most pronounced effect on the rate parameters, which can be understood in terms of the relative destabilisation of the reactant and reduced quantum mechanical tunneling through the barrier. The use of different models for tunneling suggests that when coupled with the SM5.4/PM3 method, the higher level of theories tend to overestimate the degree of tunneling.
Studies on the etiologic agent of turkey coryza / (1985)

This reproduction w as m ade from a copy of a m an u scrip t sen t to u s for publication and m icrofilm ing.While th e m o st advanced technology h a s b een u se d to p h o tograph an d reproduce th is m an u scrip t, th e quality of th e reproduction is heavily dependent u p o n th e quality of the m aterial subm itted.Pages in any m an u scrip t may have in d istin ct p rin t.In all cases th e b est available copy h as been filmed.The following explanation of techniques is provided to help clarify n o tatio n s w hich may appear on th is reproduction.1. M anuscripts may n o t always be complete.When it is n o t possible to obtain m issing pages, a note appears to indicate this. 2. When copyrighted m aterials are removed from th e m anuscript, a note ap pears to indicate th is. 3. Oversize m aterials (m aps, draw ings, an d charts) are photographed by sec tioning th e original, beginning a t the up p er left h an d com er an d co n tin u ing from left to rig h t in equal sections w ith small overlaps.E ach oversize page is also film ed a s one exposure an d is available, for a n ad d itio n al charge, as a stan d ard 35m m slide or in black an d w hite paper format.*4. Most photographs reproduce acceptably on positive microfilm or micro fiche b u t lack clarity on xerographic copies m ade from the microfilm.For a n a d d itio n al ch arg e, all p h o to g rap h s are available in black a n d w hite stan d ard 35m m slide format.
Comparative in vitro and in vivo studies with four radiolabelled somatostatin analogues in patients with endocrine tumours (1995)

Li, S. R.; Yang, Q.; Leimer, M.; Raderer, M.; Kurtaran, A.; Angelberger, P.; Niederle, B.; Scheithauer, W.; Valent, P.; Virgolini, I. Author Information
Bleeding Esophageal Varices and Hepatic Dysfunction in Adult Polycystic Kidney Disease (1984)

No AccessJournal of Urology1 Dec 1984Bleeding Esophageal Varices and Hepatic Dysfunction in Adult Polycystic Kidney Disease P.J. Ratcliffe, S. Reeders, and J.M. Theaker P.J. RatcliffeP.J. Ratcliffe More articles by this author , S. ReedersS. Reeders More articles by this author , and J.M. TheakerJ.M. Theaker More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)50152-4AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Bleeding Esophageal Varices and Hepatic Dysfunction in Adult Polycystic Kidney Disease." The Journal of Urology, 132(6), p. 1290 © 1984 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 132Issue 6December 1984Page: 1290 Advertisement Copyright & Permissions© 1984 by The American Urological Association Education and Research, Inc.MetricsAuthor Information P.J. Ratcliffe More articles by this author S. Reeders More articles by this author J.M. Theaker More articles by this author Expand All Advertisement PDF DownloadLoading ...
Radiation induces an antitumour immune response to mouse melanoma (2009)

The present study suggests that neoadjuvant irradiation of cutaneous melanoma tumours prior to surgical resection can stimulate an endogenous anti-melanoma host immune response.
Electrochemical Synthesis of Mesoporous Architectured Ru Films Using Supramolecular Templates (2020)

The electrochemical synthesis of mesoporous ruthenium (Ru) films using sacrificial self-assembled block polymer micelles templates, and its electrochemical surface oxidation to RuO<sub>x</sub> is described. Unlike standard methods such as thermal oxidation, the electrochemical oxidation method described here retains the mesoporous structure. Ru oxide materials serve as high-performance supercapacitor electrodes due to their excellent pseudocapacitive behavior. The mesoporous architectured film shows superior specific capacitance (467 F g<sup>-1</sup><sub>Ru</sub> ) versus a nonporous Ru/RuO<sub>x</sub> electrode (28 F g<sup>-1</sup><sub>Ru</sub> ) that is prepared via the same method but omitting the pore-directing polymer. Ultrahigh surface area materials will play an essential role in increasing the capacitance of this class of energy storage devices because the pseudocapacitive redox reaction occurs on the surface of electrodes.
Beam Steering and Signal Amplification Through Feedforward Networks. Part I: Transmission (2022)

Conventional and modern methods for beam steering in antennas and radar systems have one goal in common: to manipulate the phase shift between oscillating components, so that the direction of a radiating intensity pattern can be controlled. Typical components include arrays of nonlinear oscillators connected in a chain configuration. Modern methods for beam steering take advantage of the inherent nonlinearities of the individual components and of the collective dynamics of the array of oscillators to successfully manipulate phase shift. None of those methods include, however, signal amplification. In this manuscript, we introduce a novel array configuration: a feedforward network, which allows, simultaneously, for beam steering and signal amplification capabilities. We show that the amplitudes of certain bifurcating solutions in a feedforward network of nonlinear oscillators exhibit growth rates that are significantly larger than in other type of networks that operate near the onset of a Hopf bifurcation. Those branches of oscillations have the potential to lead to significant signal amplification of a radiating beam.
Chaotic mixing in crystalline granular media (2019)

We study the Lagrangian kinematics of steady three-dimensional Stokes flow over simple cubic (SC) and body-centred cubic (BCC) lattices of close-packed spheres, and uncover the mechanisms governing chaotic mixing in these crystalline structures. Due to the cusp-shaped sphere contacts, the topology of the skin friction field is fundamentally different to that of continuous (non-granular) media, such as open pore networks, with significant implications for fluid mixing. Weak symmetry breaking of the flow orientation with respect to the lattice symmetries imparts a transition from regular to strong chaotic mixing in the BCC lattice, whereas the SC lattice only exhibits weak mixing. Whilst the SC and BCC lattices posses the same symmetry point group, these differences are explained in terms of their space groups. This insight is used to develop accurate predictions of the Lyapunov exponent distribution over the parameter space of mean flow orientation. These results point to a general theory of mixing and dispersion based upon the inherent symmetries of arbitrary crystalline structures.
Robust Mesoporous CoMo/γ-Al2O3 Catalysts from Cyclodextrin-Based Supramolecular Assemblies for Hydrothermal Processing of Microalgae: Effect of the Preparation Method (2018)

Hydrothermal liquefaction (HTL) is a promising technology for the production of biocrude oil from microalgae. Although this catalyst-free technology is efficient under high-temperature and high-pressure conditions, the biocrude yield and quality can be further improved by using heterogeneous catalysts. The design of robust catalysts that preserve their performance under hydrothermal conditions will be therefore very important in the development of biorefinery technologies. In this work, we describe two different synthetic routes (i.e., impregnation and cyclodextrin-assisted one-pot colloidal approach), for the preparation in aqueous phase of six high surface area CoMo/γ-Al<sub>2</sub>O<sub>3</sub> catalysts. Catalytic tests performed on the HTL of Nannochloropsis gaditana microalga indicate that solids prepared by the one-pot colloidal approach show higher hydrothermal stability and enhanced biocrude yield with respect to the catalyst-free test. The positive effect of the substitution of the block copolymer Tetronic T90R4 for Pluronic F127 in the preparation procedure was evidenced by diffuse reflectance UV-visible spectroscopy, X-ray diffraction, N<sub>2</sub>-adsorption-desorption, and H<sub>2</sub>-temperature-programmed reduction measurements and confirmed by the higher quality of the obtained biocrude, which exhibited lower oxygen content and higher-energy recovery equal to 62.5% of the initial biomass.
ChemInform Abstract: A Simple Preparation of Several New 2,3‐ and 1,2,3‐Substituted Buta‐1,3‐dienes from 1,4‐Dichlorobutyne. The Diels‐Alder Reactivity of Some New Sulfur (Selenium) Substituted Halobutadienes. (1983)

Abstract 1,4‐Dichlor‐2‐butin (I) reagiert mit Phenylsulfenyl‐ und ‐selenyl‐halogeniden (II) zu den Addukten (III), die mit Aluminium‐ Amalgam zu den Dienen (IV) reduziert werden.
A Concise Synthesis of an Indenopyrrolidine-based Dual avb3/avb5 Integrin Antagonist (2004)

A new class of dual α V β 3 /α V β 5 integrin antagonists containing a central cis-fused cyclopentane ring was identified.Because of its increased structural rigidity, the indenopyrrolidine ring system provides insight into the active conformation of other α V β 3 ligands.A concise synthesis of the indenopyrrolidine ring system was accomplished by 1,3-dipolar cycloaddition.Individual isomers of the most active compound were separated by chiral HPLC and their biological activities were compared.
Towards reliable directed self-assembly lithography for future CMOS scaling: A study on variability of cylindrical patterns (2015)

Directed self-assembly (DSA) of block co-polymers (BCP) is a promising candidate for frequency\nmultiplication below 20nm half-pitch. In this study we will focus on the generation of holes using\ncylindrical phase BCP materials. One way to do so, is by means of grapho-epitaxy where physical\nconfinement is used. Grapho-epitaxy is preferentially used for generating more random patterns\ncompared to chemo-epitaxy making it of particular interest for logic applications. Conventional\nlithography techniques are used to create a pre-patterned template. After surface energy\nmodification, the BCP is deposited in the pre-patterned holes and annealed at elevated temperature.\nDuring the anneal the polymer phase separates and forms the desired cylindrical patterns.\nSubsequently, the minority block is removed by a wet development step (Figure 1). [1]\nIssues that need to be tackled before DSA can be implemented in device manufacturing are\nplacement accuracy and dimensional variability of the contact holes. This problem is complicated\nby the fact that the metrology for pattern placement accuracy for DSA applications is not fully\ndeveloped. Current methods mainly depend on simultaneous observation of the template and the\nBCP structure. The drawback of this approach is that the template contour is often impacted by\nthe BCP processing, resulting in increased metrology noise for measuring the template position.\nThis work focusses on the origin and impact of different parameters on the CD and placement\nvariability. First, novel metrology structures are evaluated for the characterization of DSA pattern\nplacement accuracy. Second, experiments are set up to determine the parameters that need to be\ncontrolled for high fidelity pattern formation. These include the geometry and substrate surface\nenergy of the physical confinement well, the impact of BCP material related properties, and the\nimpact of processing conditions.
Plasma Fibronectin Promotes Lung Metastasis by Contributions to Fibrin Clots and Tumor Cell Invasion (2010)

The attachment of circulating tumor cells to the blood vessels of distant organs is an important step in metastasis. We show here that experimental lung metastasis by two cell lines, B16F1 melanoma and 3LL lung carcinoma, is greatly reduced in transgenic mice that lack plasma fibronectin. This multifunctional adhesive glycoprotein becomes cross-linked to fibrin during clotting. Here, we report that eliminating plasma fibronectin from the blood circulation reverses the prometastatic effects of blood clotting and tumor cell integrin alphavbeta3. In vitro studies showed that fibrin-fibronectin complexes, but not purified fibrin, supported tumor cell attachment and invasion. These functions correlate with the ability of fibrin-fibronectin complexes to induce the activation of integrin alphavbeta3. Our findings reveal an important contribution of plasma fibronectin in lung metastasis. Furthermore, they suggest that the previously noted effects of blood clotting on lung metastasis might be mediated in part by a fibronectin-alphavbeta3 integrin axis, in which plasma fibronectin has to be incorporated into the blood clot.
Do Stereo Display Deficiencies Affect 3D Pointing? (2018)

Previous work has documented that limitations of current stereo display systems affect depth perception. We performed an experiment to understand if such stereo display deficiencies affect 3D pointing for targets in front of a screen and close to the user, i.e., in peri-personal space. Our experiment compares isolated movements with and without a change in visual depth for virtual targets. Results indicate that selecting targets along the depth axis is slower and has less throughput than laterally positioned targets.
Ionic conductivity of NASICON through aliovalent cation substitution (2023)

The present invention is directed to solid NASICON electrolytes in which the zirconium site is doped with a 2+ oxidation state cation. The present invention is also directed to methods of making the solid electrolytes and methods of using the solid electrolytes in batteries and other electrochemical technologies.
Use of Fillers as Adjunct Therapy for the Treatment of Lower Face Hemifacial Spasm (2013)

The treatment of hemifacial spasm with periorbital injections of higher doses of botulinum toxin can create disfiguring and undesirable weakness in the lower face during active facial movements. The use of asymmetric hyaluronidate filler injections to the lower face provides a refinement allowing for a lowered neurotoxin dose. The filler creates a ballasting effect and involuntary facial movement. The conventional filler effect also further reduces asymmetric nasolabial folds and marionette lines. Fifteen of 18 patients with lower facial spasms found the filler toxin combination an improvement over neurotoxin alone.
Immersion graded index optics for passive solar concentrators (2015)

Immersion graded refractive index optics enable passive optical concentrators, but also present challenges in design, fabrication, and integration. In this paper, we describe two simple and scalable fabrication techniques and report on the performance of prototypes. We present two tileable designs and demonstrate a passive concentration of 3 Suns.