gebhart/patrepeval huggingface dataset:
Susceptibility of swine cells and domestic pigs to SARS-CoV-2 (2020)

The emergence of SARS-CoV-2 has resulted in an ongoing global pandemic with significant morbidity, mortality, and economic consequences. The susceptibility of different animal species to SARS-CoV-2 is of concern due to the potential for interspecies transmission, and the requirement for pre-clinical animal models to develop effective countermeasures. In the current study, we determined the ability of SARS-CoV-2 to (i) replicate in porcine cell lines, (ii) establish infection in domestic pigs via experimental oral/intranasal/intratracheal inoculation, and (iii) transmit to co-housed naive sentinel pigs. SARS-CoV-2 was able to replicate in two different porcine cell lines with cytopathic effects. Interestingly, none of the SARS-CoV-2-inoculated pigs showed evidence of clinical signs, viral replication or SARS-CoV-2-specific antibody responses. Moreover, none of the sentinel pigs displayed markers of SARS-CoV-2 infection. These data indicate that although different porcine cell lines are permissive to SARS-CoV-2, five-week old pigs are not susceptible to infection via oral/intranasal/intratracheal challenge. Pigs are therefore unlikely to be significant carriers of SARS-CoV-2 and are not a suitable pre-clinical animal model to study SARS-CoV-2 pathogenesis or efficacy of respective vaccines or therapeutics.
On the Feasibility of Electrification for Large Mobile Cranes (2020)

Trends towards vehicle electrification to reduce dependence on fossil fuels and increase drive train efficiency have led vehicle manufacturers to seek out paths towards gradual hybridization. For heavy duty construction vehicles, electrification consists of two principle components: electric hybridization of the vehicle carrier and the vehicle's auxiliary function. Economic and physical feasibility for the transition to electrical replacements for critical system components is important for the gradual development of electrified systems. In this paper, we present an investigation into multiple pathways for the hybridization of mobile cranes paired with simulations that analyze the feasibility of system electrification. ADVISOR was used to compare the feasibility of hybrid topologies for the vehicle carrier of a crane using approximate emissions, fuel economy, and efficiency. Analysis of the feasibility of transitioning to an electric motor for the crane's auxiliary function was performed using ANSYS TwinBuilder. Issues concerning satisfying the current draw of electric motors for both simulations point to currently available energy storage systems as the main factor hindering the electrification of mobile crane systems without significant redesign due to the initial cost, upkeep, and lack of energy density.
An ab Initio and Photoelectron Spectroscopic Study of the Trichloromethyl Radical and Cation (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAn ab Initio and Photoelectron Spectroscopic Study of the Trichloromethyl Radical and CationEric S. J. Robles and Peter ChanCite this: J. Phys. Chem. 1994, 98, 28, 6919–6923Publication Date (Print):July 1, 1994Publication History Published online1 May 2002Published inissue 1 July 1994https://pubs.acs.org/doi/10.1021/j100079a006https://doi.org/10.1021/j100079a006research-articleACS PublicationsRequest reuse permissionsArticle Views70Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Supplementary Figures from Changes in CT Radiomic Features Associated with Lymphocyte Distribution Predict Overall Survival and Response to Immunotherapy in Non–Small Cell Lung Cancer (2023)

&lt;p&gt;Supplemental Figures&lt;/p&gt;
ASSESSMENT OF NATURAL RADIONUCLIDE CONTENTS AND IMPACTS IN THE MUD SOIL OF IDO-IJESA, SOUTH- WESTERN NIGERIA (2016)

There has been great concern about the health risks associated with exposure to natural radioactivity present in soil and building materials, which could be traceable to either natural or artificial sources. Thus in this work, the natural radionuclide contents of the mud soil of Ido-Ijesa in South West Nigeria; which is commonly used as building material were analyzed . The analysis was carried out by means gamma ray spectrometry using NaI (TI) as the detector. The radioisotopes identified in the samples of the material include those of the series headed by 238U and 232Th as well as the singly occurring radioisotope 40K. The mean activity concentrations of the radionuclides were found to be 23.39±3.20, 19.37±2.60 and 165.14±7.10 Bq/kg for 226Ra, 232Th and 40K respectively. The activity index of this material was found to be 0.24±0.03. This is less than the requirement of 1 for material used in bulk amounts. Assessment of the radiological impact was made by calculating the radium equivalent activity, external and internal hazard indices and the annual effective dose equivalent and all were found to be within acceptable limit.
A deep learning image-based intrinsic molecular subtype classifier of breast tumors reveals tumor heterogeneity that may affect survival (2020)

Here, we present a method for minimizing manual work required to identify cancer-rich patches among all multiscale patches in H&E-stained WSIs that can be generalized to any indication. These results suggest that advanced deep machine learning methods that use only routinely collected whole-slide images can approximate RNA-seq-based molecular tests such as PAM50 and, importantly, may increase detection of heterogeneous tumors that may require more detailed subtype analysis.
Evaluation of de novo transcriptome assemblies from RNA-Seq data (2014)

Abstract De novo RNA-Seq assembly facilitates the study of transcriptomes for species without sequenced genomes, but it is challenging to select the most accurate assembly in this context. To address this challenge, we developed a model-based score, RSEM-EVAL, for evaluating assemblies when the ground truth is unknown. Our experiments show that RSEM-EVAL correctly reflects assembly accuracy, as measured by REF-EVAL, a refined set of ground-truth-based scores that we also developed. With the guidance of RSEM-EVAL, we assembled the transcriptome of the regenerating axolotl limb; this assembly compares favorably to a previous assembly.
Operational Amplifier Based Test Structure for Quantifying Transistor Threshold Voltage Variation (2009)

A new test structure has been developed, which is comprised of MOSFET arrays and an on-chip operational amplifier feedback loop for measuring threshold voltage variation. The test structure also includes an on-chip clock generator and address decoders to scan through the arrays. It can be used in an inline test environment to provide rapid assessment of Vt variation for technology development and chip manufacturing. Hardware results in a 65-nm technology are presented. The significance of the bias dependence of Vt variation is discussed for SRAM product designs.
System design and performance of reconfigurable and simultaneous 2D multiple-plane WDM optical interconnects (1997)

System design and performance for reconfigurable and simultaneous 2-D multiple-plane WDM optical interconnects has been investigated. Device characteristics such as detector responsivity shape, efficiency, and complexity impact design requirements on wavelength separation and channel power. For reconfigurable interconnects, signal power penalties impact system design whereas for simultaneous interconnects, power penalties as well as optical crosstalk from the detection of undesired channels impact system design.
Modeling studies on alternative EUV mask concepts for higher NA (2013)

This paper investigates the performance of different mask options for sub-13 nm EUV-lithography with a 4x demagnification and an NA of 0.45. The considered mask options include standard binary masks, standard attenuated phase-shift masks, etched attenuated phase-shift masks and embedded-shifter phase-shift masks. The lithographic performance of these masks is investigated and optimized in terms of mask efficiency, NILS, DoF, OPC-performance and telecentricity errors. A multiobjective optimization technique is used to identify the most promising mask geometry parameters.
Docetaxel-Loaded PLGA Nanoparticles Improve Efficacy in Taxane-Resistant Triple-Negative Breast Cancer (2016)

Novel treatment strategies, including nanomedicine, are needed for improving management of triple-negative breast cancer. Patients with triple-negative breast cancer, when considered as a group, have a worse outcome after chemotherapy than patients with breast cancers of other subtypes, a finding that reflects the intrinsically adverse prognosis associated with the disease. The aim of this study was to improve the efficacy of docetaxel by incorporation into a novel nanoparticle platform for the treatment of taxane-resistant triple-negative breast cancer. Rod-shaped nanoparticles encapsulating docetaxel were fabricated using an imprint lithography based technique referred to as Particle Replication in Nonwetting Templates (PRINT). These rod-shaped PLGA-docetaxel nanoparticles were tested in the C3(1)-T-antigen (C3Tag) genetically engineered mouse model (GEMM) of breast cancer that represents the basal-like subtype of triple-negative breast cancer and is resistant to therapeutics from the taxane family. This GEMM recapitulates the genetics of the human disease and is reflective of patient outcome and, therefore, better represents the clinical impact of new therapeutics. Pharmacokinetic analysis showed that delivery of these PLGA-docetaxel nanoparticles increased docetaxel circulation time and provided similar docetaxel exposure to tumor compared to the clinical formulation of docetaxel, Taxotere. These PLGA-docetaxel nanoparticles improved tumor growth inhibition and significantly increased median survival time. This study demonstrates the potential of nanotechnology to improve the therapeutic index of chemotherapies and rescue therapeutic efficacy to treat nonresponsive cancers.
Cold-cathode, pulsed-power plasma discharge switch (1996)

CROSSATRONTMmodulator switches are cold-cathode, grid-controlled, plasma-discharge devices that are used for thyratron and hard-tube replacement in high-voltage, pulsed-power applications. CROSSATRON modulator switches have been used to produce square pulses of up to 100 kV and 1000 A, and CROSSATRON laser-discharge switches have switched peak discharge currents of up to 10 kA at 40 kV. The major advantage that CROSSATRON switches offer over other plasma switches is a rapid deionization time that permits high pulse-repetition frequencies (103 to 106 pulses per second depending on the application), and a long life associated with the cold-cathode plasma production mechanism. Compared to hard tubes, CROSSATRON switches have a relatively low forward voltage drop (500 V), the ability to close and open up to 1 kA of peak current, and lower grid-drive power requirements. In this article, we describe the physical mechanisms for how the switch works based on simple models and experimental data. The design of CROSSATRON switches is explained, and characteristic performance in closing and opening applications is described and explained.
Continuous time analog filter circuits testing using PRBS input vectors (2004)

This paper outlines the problems associated with testing analog and mixed-signal circuits. It discusses the failure modes and fault models used. It then proposes a go no go test method for analog circuits. The method is based on the excitation of the circuit-under-test with a pseudo random binary sequence and the subsequent analysis of the captured response. The fault detection capabilities of the test and data analysis method are demonstrated by applying them to a continuous time filter circuit operating in the mid-band frequency range. An initial assessment of the impact of the input test sequence length on the detectability of faults is also discussed.
Handling Delays in Yaw Rate Control of Electric Vehicles Using Model Predictive Control With Experimental Verification (2017)

In this paper, a new approach is proposed to deal with the delay in vehicle stability control using model predictive control (MPC). The vehicle considered here is a rear-wheel drive electric (RWD) vehicle. The yaw rate response of the vehicle is modified by means of torque vectoring so that it tracks the desired yaw rate. Presence of delays in a control loop can severely degrade controller performance and even cause instability. The common approaches for handling delays are often complex in design and tuning or require an increase in the dimensions of the controller. The proposed method is easy to implement and does not entail complex design or tuning process. Moreover, it does not increase the complexity of the controller; therefore, the amount of online computation is not appreciably affected. The effectiveness of the proposed method is verified by means of carsim/simulink simulations as well as experiments with a rear-wheel drive electric sport utility vehicle (SUV). The simulation results indicate that the proposed method can significantly reduce the adverse effect of the delays in the control loop. Experimental tests with the same vehicle also point to the effectiveness of this technique. Although this method is applied to a vehicle stability control, it is not specific to a certain class of problems and can be easily applied to a wide range of model predictive control problems with known delays.
Magneto-Optical Spectroscopy of Anatase TiO2 Doped with Co (2002)

Magneto-optical spectroscopy of a transparent ferromagnetic semiconductor, anatase TiO2 doped with Co, is carried out at room temperature. A large magneto-optical response with ferromagnetic field dependence is observed throughout from ultraviolet to visible range and increases with increasing Co content or carrier concentration. The magnitude of magnetic circular dichroism (MCD) per unit thickness has a peak around the absorption edge such a huge value of ~10400 degree/cm at 3.57 eV for a 10 mol% Co-doped specimen. Although the results are not sufficient to prove that the ferromagnetism is in the ordinary framework of diluted magnetic semiconductors, the coexistence of Co impurity and mobile carrier is shown to transform the band structure of host TiO2 to generate ferromagnetism.
Poly[[diaquadeca-μ2-cyanido-κ20C:N-hexacyanido-κ6C-bis(μ2-5-methylpyrimidine-κ2N:N′)bis(5-methylpyrimidine-κN)tricopper(II)ditungstate(V)] dihydrate] (2014)

In the title complex, {[Cu3[W(CN)8]2(C5H6N2)4(H2O)2]·2H2O} n , the coordination polyhedron of the eight-coordinated W(V) atom is a bicapped trigonal prism, in which five CN groups are bridged to Cu(II) ions, and the other three CN groups are terminally bound. Two of the Cu(II) ions lie on a centre of inversion and each of the three independent Cu(II) cations is pseudo-octahedrally coordinated. In the crystal structure, cyanido-bridged-Cu-W-Cu layers are linked by pillars involving the third independent Cu(II) ion, generating a three-dimensional network with non-coordinating water mol-ecules and 5-methyl-pyrimidine mol-ecules. O-H⋯O and O-H⋯N hydrogen bonds involve the coordinating and non-coordin-ating water mol-ecules, the CN groups and the 5-methyl-pyrimidine mol-ecules.
Starch Biosynthetic Enzymes from Developing Maize Endosperm Associate in Multisubunit Complexes (2008)

Mutations affecting specific starch biosynthetic enzymes commonly have pleiotropic effects on other enzymes in the same metabolic pathway. Such genetic evidence indicates functional relationships between components of the starch biosynthetic system, including starch synthases (SSs), starch branching enzymes (BEs), and starch debranching enzymes; however, the molecular explanation for these functional interactions is not known. One possibility is that specific SSs, BEs, and/or starch debranching enzymes associate physically with each other in multisubunit complexes. To test this hypothesis, this study sought to identify stable associations between three separate SS polypeptides (SSI, SSIIa, and SSIII) and three separate BE polypeptides (BEI, BEIIa, and BEIIb) from maize (Zea mays) amyloplasts. Detection methods included in vivo protein-protein interaction tests in yeast (Saccharomyces cerevisiae) nuclei, immunoprecipitation, and affinity purification using recombinant proteins as the solid phase ligand. Eight different instances were detected of specific pairs of proteins associating either directly or indirectly in the same multisubunit complex, and direct, pairwise interactions were indicated by the in vivo test in yeast. In addition, SSIIa, SSIII, BEIIa, and BEIIb all comigrated in gel permeation chromatography in a high molecular mass form of approximately 600 kD, and SSIIa, BEIIa, and BEIIb also migrated in a second high molecular form, lacking SSIII, of approximately 300 kD. Monomer forms of all four proteins were also detected by gel permeation chromatography. The 600- and 300-kD complexes were stable at high salt concentration, suggesting that hydrophobic effects are involved in the association between subunits.
Total Syntheses of Indicine N-Oxide, Intermedine N-Oxide, and Their Enantiomers Using Carbohydrate as a Chiral Educt (1987)

Abstract The first completely enantioselective syntheses of indicine N-oxide, intermedine N-oxide, and their enantiomers have been achieved stereospecifically. A synthetic analogue modeled on indicine N-oxide showed the superior activity to indicine N-oxide itself against cancer cell in vitro test.
Presentation, management, and outcomes of cauda equina syndrome up to one year after surgery, using clinician and participant reporting: a multi-centre prospective cohort study (2022)

DCN Endowment Fund funded study administration. Castor EDC provided database use. No other study funding was received.
Structure and phase transitions of grown and equilibrated alloys (1990)

We explore the relationship between cellular-automata-based growth models and equilibrium thermodynamic models of material structure. Application is to the growth of (GaAs${)}_{1\mathrm{\ensuremath{-}}\mathit{x}}$${\mathrm{Si}}_{2\mathit{x}}$-type alloys. As a function of x these alloys have an order-disorder phase transition. We address a controversy over the relevance of growth models or equilibrium statistical models to the description of the alloy structure, and particularly the critical properties of the phase transition. Experiments to determine the relevance of the models are proposed.
Inhibitory effect of alkylating modulators on the function of P-glycoprotein. (1997)

Modulators of P-glycoprotein (P-gp) are often themselves transported out of cells, thereby limiting their effectiveness. It may be possible to develop more effective modulators of multidrug resistance by designing drugs that irreversibly block the function of P-gp. Therefore, we studied the effect of the mustard derivatives of fluphenazine (FPN) and trans-flupenthixol (FPT) on P-gp function. Both fluphenazine-mustard (FPN-M) and trans-flupenthixol-mustard (FPT-M) possessed alkylating activity, as assayed using 4-(p-nitrobenzyl) pyridine. Multidrug-resistant MCF-7/AdrR cells were incubated with FPN or FPN-M, or FPT or FPT-M for 1 h, washed for varying number of times in phosphate-buffered saline (PBS), then resuspended in medium containing [3H]vinblastine (VBL), and assayed for steady-state accumulation of the drug. Washing had far less of an effect on the ability of FPN-M and FPT-M to increase VBL accumulation compared to their parent compounds. After eight washes in excess PBS, the cells initially exposed to FPN or FPT accumulated only 30% and 50% of the initially accumulated drug, whereas the FPN-M- or FPT-M-treated cells accumulated approximately 75% and 90% of the control, respectively. FPN-M and FPT-M also increased the uptake and decreased the efflux of VBL from MDR cells despite repeated washing. We also examined the effects of these modulators on sensitivity of MDR cells to cytotoxic agents. FPN-M and FPT-M sensitized MCF-7/AdrR cells to VBL and doxorubicin to a greater extent than their parent compounds. These studies point out the potential of "irreversible" P-gp modulators to produce prolonged chemosensitization.
Optimization of a rotary Q-switched Er:YAG laser (2002)

An erbium:yttrium–aluminum–garnet Er:YAG (λ=2.94 μm) rotary Q-switched laser was optimized for long-term stability and reliability, maximum output energy, and TEMoo mode quality. This optimization was achieved employing a close-coupled BaSO4 diffuse reflector pump chamber and a dehumidifying assembly and an ultra-dry-air purge system. The performance and efficiency of the Er:YAG laser were further enhanced by appropriate variations in the coolant temperature, rotational frequency of the Q-switch mirror, and pulse repetition rate. These improvements should facilitate the implementation of rotating mirror Q-switched Er:YAG lasers in various laser photoablation and depth-profiling applications.
The Muscarinic Acetylcholine Receptor M 5 : Therapeutic Implications and Allosteric Modulation (2018)

The muscarinic acetylcholine receptor (mAChR) subtype 5 (M<sub>5</sub>) was the most recent mAChR to be cloned and has since emerged as a potential therapeutic target for a number of indications. Early studies with knockout animals have provided clues to the receptor's role in physiological processes related to Alzheimer's disease, schizophrenia, and addiction, and until recently, useful subtype-selective tools to further probe the pharmacology of M<sub>5</sub> have remained elusive. Small-molecule allosteric modulators have since gained traction as a means by which to selectively examine muscarinic pharmacology. This review highlights the discovery and optimization of M<sub>5</sub> positive allosteric modulators (PAMs) and negative allosteric modulators (NAMs).