gebhart/patrepeval huggingface dataset:
Effects of Halothane on the Conduction System of the Heart in Humans (1989)

The effects of 2.0 MAC halothane on atrioventricular conduction times in humans were studied. A real-time recording system for the detection of surface His-Purkinje potentials based on signal averaging techniques was used. Recordings were made in 23 patients before and after the administration of halothane. In 18 patients we were able to measure atrial (P-H) and His-Purkinje (H-V) conduction times (78%). A small but statistically significant decrease in P-H conduction times from 115.3 +/- 3.9 (SEM) to 110.8 +/- 4.2 ms was found (P less than or equal to 0.01). H-V conduction times did not change significantly. Heart rates decreased significantly from 87.6 +/- 2.6 to 74.8 +/- 2.5 beats/min (P less than or equal to 0.01). Systolic blood pressures decreased from 118.9 +/- 3.7 to 103.6 +/- 4.2 mm Hg. It is concluded that the decrease in heart rate and the decrease in atrial conduction time caused by halothane can be explained by interactions of several different mechanisms. The specific combination of slowing heart rate and a decrease of atrial conduction time provides a possible explanation for atrial arrhythmias during the administration of halothane.
A TRANSVERSE FLOW cw HCl CHEMICAL LASER (1971)

A cw HCl chemical laser utilizing fast flow and transverse geometry is described. The reaction Cl + HI → HCl + I + 32 kcal/mole is used to achieve gains in excess of 2%/cm. Up to 70 mW of multiline power on several P branch lines of the 2→1 and 1→0 vibrational transitions has been observed.
ChemInform Abstract: HOST‐GUEST COMPLEXATION. 3. ORGANIZATION OF PYRIDYL BINDING SITES (1977)

Abstract Die Synthesen der Heteromakrocyclen (Ia)‐(Ic), (II ‐(V) werden zunächst beschrieben; als Ausgangssubstanzen hierfür dienen die Monopyridoverbindungen (VI), (VIIa), (VIIb) (getrenntes Gemisch; aus (VI)), (XII) und die Dipyridoverbindung (IXc) (aus (VIII) über die Stufen (IXa) und (IXb) (Persäure‐Oxidation von (IXa) unter Acetylierung)).
Discovery of VU6027459: A First-in-Class Selective and CNS Penetrant mGlu7 Positive Allosteric Modulator Tool Compound (2020)

Herein, we report the discovery of the first selective and CNS penetrant mGlu<sub>7</sub> PAM (VU6027459) derived from a "molecular switch" within a selective mGlu<sub>7</sub> NAM chemotype. VU6027459 displayed CNS penetration in both mice (K<sub>p</sub> = 2.74) and rats (K<sub>p</sub>= 4.78), it was orally bioavailable in rats (%F = 69.5), and undesired activity at DAT was ablated.
Theoretical and Experimental Analysis of Back-Gated SOI MOSFETs and Back-Floating NVRAMs (2004)

Back-gated silicon-on-insulator MOSFET - a threshold-voltage adjustable device-employs a constant back-gate potential to terminate source- drain electric fields and to provide carrier confinement in the channel. This suppresses short- channel effects of nano-scale and of high drain biases, while allowing a means to threshold voltage control. We report here a theoretical analysis of this geometry to identify its natural length scales, and correlate the theoretical results with experimental device measurements. We also analyze experimental electrical characteristics for misaligned back-gate geometries to evaluate the influence on transport behavior from the device electrostatics due to the structure and position of the back-gate. The back- gate structure also operates as a floating-gate non- volatile memory (NVRAM) when the back-gate is floating. We summarize experimental and theoretical results that show the nano-scale scaling advantages of this structure over the traditional front floating-gate NVRAM.
Heat- and Cold-induced Injuries in Athletes: Evaluation and Management (2012)

Both extreme heat and cold can be challenging for athletes during training and competition. One role of the team physician is to educate coaches and athletes on the risks of exposure to these conditions and how to best prevent and manage their adverse effects. Heat illness varies in degree from mild to severe, with the most severe forms being potentially fatal. Cold exposure can result in systemic effects and peripheral injury to the extremities.
Spectroscopic study of microwave-enhanced silicon exfoliation (2008)

Infrared spectroscopy and Rutherford backscattering spectrometry are used to study the effect of microwaves on hydrogen implanted silicon. Infrared spectra demonstrate that the hydride species formed in hydrogen implant and microwave annealed silicon result in exfoliation in a manner similar to that in conductively annealed samples. The infrared spectra of microwave annealed samples reveal an increase in internal surface formation prior to exfoliation. This increase in internal surface formation demonstrates how microwave anneals can decrease the incubation time required prior to exfoliation. Rutherford backscattering and infrared spectra are presented to elucidate the minimized impact of the microwave effect in boron-hydrogen coimplanted silicon.
Comparison of Battlefield-Expedient Topical Antimicrobial Agents for the Prevention of Burn Wound Sepsis in a Rat Model (2005)

Topical antimicrobial therapy has the potential to limit the mortality and morbidity of contaminated battlefield injuries. Many agents available are ill-suited for use on the battlefield; however, mafenide acetate solution (MAS) has known efficacy as a burn dressing adjunct, and previous work with mafenide as a direct chemotherapeutic has shown promise. A total of 71 male Sprague-Dawley rats underwent a 20% TBSA full-thickness scald. Wounds were inoculated with a solution containing 1 x 10 colony-forming units per milliliter of Pseudomonas aeruginosa 1244 (ATCC 27317). Treatments with 10% mafenide acetate cream (MAC), 5% MAS, 5% mafenide hydrochloride solution (MHS), and 4% chlorhexidine gluconate solution (CHG) were established. Agents were applied directly to the wound daily for 10 days. Animals were monitored for 21 days and euthanized if they manifested a moribund state as a result of sepsis. Survival to study completion in the negative control group (no treatment) was 25% (3/12). Survival in the positive control group (MAC) was 100%. None of the test agent groups demonstrated significant survival over the untreated controls; MAS resulted in 5/12 (42%) survival (P = .67), CHG in 4/12 (33%) survival (P = 1.0), and MHS resulted in 2/12 (17%) survival (P = 1.0). There were no significant differences in group weights on day 1. By day 6, all test agent groups were significantly underweight compared with the MAC group. This trend resolved as underweight animals died. We did not demonstrate significant prevention of wound sepsis with these agents as we used them. These techniques should not be substituted for established burn care. Aqueous direct topical antimicrobial agents have logistical advantages over creams and dressing soaks for field use, and the search for a battlefield-expedient agent for use at or near the point of wounding should continue.
Leveraging The D2D-Gain: Resource Efficiency Based Mode Selection for Device-to-Device Communication (2016)

It has been postulated in literature that three gain types are introduced into the radio access part of cellular networks by device-to-device communication, namely the proximity gain, hop gain and reuse gain. These gain types have further been shown to be captured by a resource efficiency metric. We investigate the influence of mode selection and scheduling on the resource efficiency gains in the D2D overlay case. We formulate mode selection as a resource efficiency maximization problem and find that for proper mode selection, the achieved resource efficiencies of schedulers must be anticipated correctly. Because this is very complex, we propose a simple, channel state based mode selection scheme and investigate how well it performs using different schedulers. We show that our proposed scheme is optimal for schedulers that do not leverage frequency diversity and optimizes a tight lower bound for those that do leverage diversity. Simulations show that in any case, our scheme produces higher D2D-gains than the state of the art.
Extracting shape reflectance of Lambertian, specular, and hybrid surfaces (1988)

All existing shape extraction techniques that are based on photometric measurements rely on assumed surface reflection properties. A method is proposed for determining the shape of surfaces whose reflectance properties may vary from Lambertian to specular without prior knowledge of the relative strengths of the Lambertian and specular components of reflection. The object surface is illuminated using extended light sources and is viewed from a single direction. Surface illumination using extended sources makes it possible to ensure the detection of both Lambertian and specular reflections. Multiple source directions are used to obtain an image sequence of the object. An extraction algorithm uses the set of image intensity values measured at each surface point to compute orientation as well as the relative strengths of the Lambertian and specular reflection components. The proposed methods has been named photometric sampling as it uses samples of a photometric function that relates image intensity to surface orientation, reflectance, and light source characteristics that describes the reflectance model and orientation of a surface point. Experiments were conducted on Lambertian surfaces, specular surfaces, and hybrid surfaces whose reflectance model is composed of both Lambertian and specular components. The results show high accuracy in measured orientations and estimated reflectance parameters. Keywords: Extraction techniques; Photometric measurements; Reflectance properties; Specular reflectance; Photometric sampling.
Mechanism of the initial stages of nitrogen-doped single-walled carbon nanotube growth (2011)

We have studied the mechanism of the initial stages of nitrogen-doped single-walled carbon nanotube growth illustrated for the case of a floating catalyst chemical vapor deposition system, which uses carbon monoxide (CO) and ammonia (NH(3)) as precursors and iron as a catalyst. We performed first-principles electronic-structure calculations, fully incorporating the effects of spin polarization and magnetic moments, to investigate the bonding and chemistry of CO, NH(3), and their fragments on a model Fe(55) icosahedral cluster. A possible dissociation path for NH(3) to atomic nitrogen and hydrogen was identified, with a reaction barrier consistent with an experimentally determined value we measured by tandem infrared and mass spectrometry. Both C-C and C-N bond formation reactions were found to be barrierless and exothermic, while a parasitic reaction of HCN formation had a barrier of over 1 eV.
Independent validation of machine learning in diagnosing breast Cancer on magnetic resonance imaging within a single institution (2019)

On an independent, consecutive clinical dataset within a single institution, a trained machine learning system yielded promising performance in distinguishing between malignant and benign breast lesions.
Cell adhesion and proliferation evaluation of SFF-based biodegradable scaffolds fabricated using a multi-head deposition system (2009)

Scaffolds composed of biodegradable polymers and biocompatible ceramics are being used as substitutes for tissue engineering. In the development of such techniques, scaffolds with a controllable pore size and porosity were manufactured using solid free-form fabrication (SFF) methods to investigate the effects of cell interactions such as cell proliferation and differentiation. In this study, we describe the adhesion of human bone marrow stromal cells (hBMSCs) and proliferation characteristics of various scaffolds, which consist of biodegradable materials, fabricated using a multi-head deposition system (MHDS) that we developed. The MHDS uses novel technology that enables the production of three-dimensional (3D) microstructures. Fabrication of 3D tissue engineering scaffolds using the MHDS requires the combination of several technologies, such as motion control, thermal control, pneumatic control and computer-aided design/computer-assisted manufacturing software. The effects of a polymer and ceramic on a tissue scaffold were evaluated through mechanical testing and cell interaction analysis of various kinds of scaffolds fabricated using polycaprolactone, poly-lactic-co-glycolic acid and tri-calcium phosphate for bone regeneration applications. Based on these results, the feasibility of application to the tissue engineering of SFF-based 3D scaffolds fabricated by the MHDS was demonstrated.
Mechanism of Recurrence of Atrial Tachycardia (2020)

Although high-resolution mapping may lead to correct diagnosis and appropriate ablation in the first procedure, the recurrence rate is still high. The main mechanism of atrial fibrillation ablation-related AT is the recurrence of PMF and RMAT or non-AMAT different from the first procedure. Epicardial structures (eg, coronary sinus/vein of Marshall system) are often involved, and ethanol infusion in the vein of Marshall may be an additional treatment.
Electric vehicle use in public fleets: The case of the Genoa University (2017)

Electric mobility is assuming a central role in the new world energy scenario where Renewable Energy Sources (RES) have increased their contribution to the electricity production, mainly due to the fact they are characterized by a reduced environmental impact; in the aforesaid context, Electric Vehicles (EVs) can play a significant role to facilitate the integration of RES into the power grid, also within smart grid infrastructures. Public administration represents one of the sectors that can mostly benefit from the use of the EV technology in its fleets; in many countries, governments have introduced incentive policies to support the spread of the electric mobility and car manufacturers are developing EVs for urban transportation users. In this paper, the attention is focused on a smart microgrid project developed at the University of Genoa and based on the integration of RES, EVs and storage systems. In particular, the attention is here pointed on the use of the EVs to highlight the different habits of recharge adopted at the Genoa University. The paper describes the smart microgrid test-bed facility at the Savona Campus and reports the most significant results relative to an experimental campaign conducted on EVs.
Summary of total mercury concentrations in fillets of selected sport fishes collected during 2000-2003 from Lake Natoma, Sacramento County, California (2004)

This report summarizes results of total mercury measurements in skinless fillets of sport fishes collected during August 2000, September?October 2002, and July 2003 from Lake Natoma, a small (8,760 acre-feet) afterbay for Folsom Dam on the lower American River. The primary objective of the study was to determine if mercury concentrations in fillets approached or exceeded guidelines for human consumption. The Food and Drug Administration (FDA) human-health action level for methylmercury in commercially caught fish is 1.0 ?g/g (microgram per gram); the U.S. Environmental Protection Agency (USEPA) human-health criterion for methylmercury residue in fish tissue is 0.30 ?g/g. Wet weight concentrations of total mercury in skinless fillets were as high as 0.19 ?g/g in bluegill (Lepomis macrochirus), 0.39 ?g/g in redear sunfish (L. microlophus), 1.02 ?g/g in largemouth bass (Micropterus salmoides), and 1.89 ?g/g in channel catfish (Ictalurus punctatus). Maximum concentrations of mercury in other fish species varied from 0.10 ?g/g in rainbow trout (Oncorhynchus mykiss) to 0.56 ?g/g in white catfish (A-meiurus catus). Altogether, 1 of 86 largemouth bass and 11 of 11 channel catfish exceeded the FDA human-health action level. In addition, 1 of 20 redear sunfish, 26 of 86 largemouth bass, 2 of 3 spotted bass (M. punctulatus), 1 of 1 brown bullhead (A. nebulosus), and 1 of 1 white catfish exceeded the USEPA human-health criterion. These results indicate that some fish species inhabiting Lake Natoma contain undesirably high concentrations of mercury in their skinless fillets.
[Measurement of carotid artery intima-media thickness. Analysis and reproducibility]. (2000)

The intima-media thickness of the carotid artery is a cardiovascular risk factor, especially in hypertensive, diabetic or dyslipidemic patients. Very accurate tools of measurement are essential in order to optimise the analysis of the severity of the vascular lesions. Present methods use computer programmes for ultrasonic image enhancement and have already been shown to be very reproducible. However, there is still room for improvement in the detection of lesions at their initial stage of development and in the follow-up of their progression with or without antihypertensive or lipid lowering drugs.
NOMA-Based Highly-Efficient Low-Latency HARQ Method for URLLC (2021)

Hybrid automatic repeat request (HARQ) is an essential technology that efficiently reduces the transmission error rate. However, for ultra-reliable low latency communications (URLLC) in the 5th generation mobile communication systems and beyond, the increase in latency due to retransmission must be minimized in HARQ. In this paper, we propose a non-orthogonal multiple access (NOMA)-based highly-efficient low-latency HARQ method for URLLC while minimizing the performance loss for coexisting services (use cases) such as enhanced mobile broadband (eMBB). In the proposed method, delay-sensitive URLLC packets are preferentially multiplexed with best-effort eMBB packets in the same channel using superposition coding to reduce the transmission latency of the URLLC packet while alleviating the throughput loss in eMBB. This is achieved using a weighted channel-aware resource allocator (scheduler). The inter-packet interference multiplexed in the same channel is removed using a successive interference canceller (SIC) at the receiver. This corresponds to non-orthogonal HARQ at the system level. Furthermore, the transmission rates for the initial transmission and retransmission are controlled in an appropriate manner for each service in order to deal with decoding errors caused by error in transmission rate control originating from a time varying channel. We show that the proposed method significantly improves the overall performance of a system that simultaneously provides eMBB and URLLC services.
Medium-dose SIMOX quality improvement for advanced CMOS applications (2002)

Reducing the oxygen dose for implanted (i.e. SIMOX) SOI material, and improving the implantation equipment and process balance, have been pursued in order to meet the requirements of the SIA ITRS (1999), increase yields and reliability of CMOS-SOI circuits, and reduce SOI wafer costs. A manufacturable "medium-dose" SIMOX process optimized for 0.18-0.13 /spl mu/m CMOS SOI technologies has been developed, yielding BOX and silicon layer thicknesses of /spl sim/150 nm and <190 nm respectively. Primary attributes of the material include low particle levels, reduced BOX and silicon defect densities, increased BOX breakdown fields, and reduced surface and interface roughness. These attributes result in improved defect detection capabilities using optical metrology tools, as well as improved BOX and gate oxide integrity.
Response to Comment on “Expansion of Effector Memory Regulatory T Cells Represents a Novel Prognostic Factor in Lower Risk Myelodysplastic Syndrome” (2012)

The letter by Gangat and Patnaik in response to the paper by Mailloux et al. ([1][1]) raises several interesting questions about effector memory regulatory T cells (TregEM) in myelodysplastic syndromes (MDS). First, we agree that the bone marrow (BM) naturally contains a higher number of Tregs
Reconfigurable Radio-over-Fibre Networks for Interference Mitigation in Linear Cell Radars (2019)

This paper proposes a novel network configuration for mitigation of interference between radar units in a linear cell radar system. For airport applications, false images would be generated by strong reflection on smooth surfaces of aircraft. Such false images due to interference between any two radar units can be suppressed by switching configuration of optical links which connect the radar units, where group delays in the links depend on the configuration.
Particle filtering for online motion planning with task specifications (2016)

A probabilistic framework for online motion planning of vehicles in dynamic environments is proposed. We develop a sampling-based motion planner that incorporates prediction of obstacle motion. A key feature is the introduction of task specifications as artificial measurements. This allows us to cast the exploration phase in the planner as a nonlinear, possibly multimodal, estimation problem, which is effectively solved using particle filtering. For certain parameter choices, the approach is equivalent to solving a nonlinear estimation problem using particle filtering. The proposed approach is illustrated on a simulated autonomous-driving example. The results indicate that our method is computationally efficient, consistent with the task specifications, and computes dynamically feasible trajectories.
Alternative Splicing of the Inhibitory Immune Checkpoint Receptor SLAMF6 Generates a Dominant Positive Form, Boosting T-cell Effector Functions (2021)

SLAMF6 is a homotypic receptor of the Ig-superfamily associated with progenitor-exhausted T cells. Here we show that in humans, SLAMF6 has three splice isoforms involving its V-domain. Although the canonical receptor inhibited T-cell activation through SAP recruitment, the short isoform SLAMF6<sup>Δ17-65</sup> had a strong agonistic effect. The costimulatory action depended on protein phosphatase SHP1 and led to a cytotoxic molecular profile mediated by the expression of TBX21 and RUNX3. Patients treated with immune checkpoint blockade showed a shift toward SLAMF6<sup>Δ17-65</sup> in peripheral blood T cells. We developed splice-switching antisense oligonucleotides (ASO) designed to target the relevant SLAMF6 splice junction. Our ASOs enhanced SLAMF6<sup>Δ17-65</sup> expression in human tumor-infiltrating lymphocytes and improved their capacity to inhibit human melanoma in mice. The yin-yang relationship of SLAMF6 splice isoforms may represent a balancing mechanism that could be exploited to improve cancer immunotherapy.
A new generation of capillary columns for separation and sample treatment: the titania monolith (2011)

International audience
Synthesis of 6-Cyano-2,2-dimethyl-2H-1-benzopyran and Other Substituted 2,2-Dimethyl-2H-1-benzopyrans (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of 6-Cyano-2,2-dimethyl-2H-1-benzopyran and Other Substituted 2,2-Dimethyl-2H-1-benzopyransJeffrey T. North, David R. Kronenthal, Annie J. Pullockaran, Sharon D. Real, and Helen Y. ChenCite this: J. Org. Chem. 1995, 60, 11, 3397–3400Publication Date (Print):June 1, 1995Publication History Published online1 May 2002Published inissue 1 June 1995https://pubs.acs.org/doi/10.1021/jo00116a025https://doi.org/10.1021/jo00116a025research-articleACS PublicationsRequest reuse permissionsArticle Views778Altmetric-Citations55LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts