gebhart/patrepeval huggingface dataset:
Real‐time imaging and quantification of p300/CBP acetyltransferase inhibition using a FRET‐based reporter in living mammalian cells (2011)

p300/CBP activate transcription by acetylating histones and other proteins and recruiting cofactors. p300/CBP act in response to a variety of signals, and their regulation of transcription controls major cellular pathways. Mutation of p300/CBP can cause Rubinstein‐Taybi syndrome, acute myeloid leukemia, and solid tumors. We have previously developed C646, a small molecule inhibitor of p300/CBP that is potent and specific in vitro . Our goal is to evaluate the pharmacodynamics of C646. Using a FRET‐based reporter in living cells, we observed that C646 is cell‐permeable, fast‐acting, and has a profound effect on histone acetylation; this effect is dose‐dependent and influenced by changes to the C646 structure. Furthermore, we found that cells with more active p300/CBP, generated either by deacetylase inhibition or p300 overexpression, respond more dramatically to C646, in contrast to cells with knocked down CBP, which do not respond to C646. We found that human melanoma cell lines are highly sensitive to C646, lending support to the view that p300/CBP are upregulated in this cancer. Thus, our work sheds light on the mechanism of oncogenesis in melanoma, as well as providing a potential therapeutic strategy. Technology Centers for Networks and Pathways, National Institutes of Health
Virus movement maintains local virus population diversity (2007)

Viruses are the largest reservoir of genetic material on the planet, yet little is known about the population dynamics of any virus within its natural environment. Over a 2-year period, we monitored the diversity of two archaeal viruses found in hot springs within Yellowstone National Park (YNP). Both temporal phylogeny and neutral biodiversity models reveal that virus diversity in these local environments is not being maintained by mutation but rather by high rates of immigration from a globally distributed metacommunity. These results indicate that geographically isolated hot springs are readily able to exchange viruses. The importance of virus movement is supported by the detection of virus particles in air samples collected over YNP hot springs and by their detection in metacommunity sequencing projects conducted in the Sargasso Sea. Rapid rates of virus movement are not expected to be unique to these archaeal viruses but rather a common feature among virus metacommunities. The finding that virus immigration rather than mutation can dominate community structure has significant implications for understanding virus circulation and the role that viruses play in ecology and evolution by providing a reservoir of mobile genetic material.
Structure and melt rheology of polystyrene-based layered silicate nanocomposites (2005)

The melt-state viscoelastic properties of exfoliated in situ polymerized and intercalated solution-blended polystyrene (PS) and organically modified montmorillonite nanocomposites were investigated and compared. The PS nanocomposites prepared by nitroxide-mediated polymerization (NMP) exhibit a stable exfoliated structure whereas the PS nanocomposites prepared by solution mixing exhibit an intercalated structure. The linear viscoelastic properties were strongly correlated with the dispersion state of the nanocomposites. On the other hand, the non-linear oscillatory shear properties exhibited shear thinning character and were consistent with the weak interactions between the polymer and the layered silicate.
Direct Observation of Phase-Free Propagation in a Silicon Waveguide (2017)

We demonstrate silicon waveguides that support phase-free propagation in the telecom regime. These waveguides have smaller footprints and exhibit improved energy transfer capabilities as compared to previous optical waveguides that support phase-advance-free modes. We measure the effective refractive index using on-chip interferometry and observe a zero-crossing around a wavelength of λ = 1625 nm. At this wavelength, we observe the coherent oscillations of waves that span the entire length of the waveguide. These waveguides are based on a 220-nm-thick silicon-on-insulator platform and, thus, are inherently compatible with established silicon photonic technologies.
Impact of screencasting on video temporal synchronization (2016)

Spatio-temporal desynchronization remains a major challenge for watermarking system as it could impair the detection of the hidden payload. Over the years, several (non-blind) registration techniques have been proposed to realign the analyzed content prior to watermark detection and thereby achieve robustness against severe attacks such as display-and-camcord. Such techniques rely on assumptions that may be invalidated by new attacks that had not been accounted for. In the case of video, for instance, best-in-class resynchronization techniques may have difficulties to cope with screencasting. In this paper, we report findings after an experimental study that involved five popular screencasting tools. The impact of screencasting can indeed be characterized in terms of frame drops and repeats. Moreover, the on-the-fly encoding process occurring during screen recapture inherently introduces dependencies between the likelihood of drop/repeat and the frame encoding type.
Dendrimeric Tectons in Halogen Bonding-Based Crystal Engineering (2007)

The use of DAB dendrimers in halogen bonding-based crystal engineering is reported. The DAB-dendr-(NHC6F4I)22 self-assembles with (E)-1,2-bis-(4-pyridyl)-ethylene in a 1:2 supramolecular adduct, whose crystal lattice is composed of 5-fold interpenetrated sql networks, which is the highest degree for a square topology reported so far. The synthesis and coordination properties of higher generation dendrimers are also described, both in the liquid state and in solution.
Thermal and Mechanical Properties of Polypropylene/Cellulose Nanofiber Composites (2020)

최근, 가장 풍부한 천연고분자 중 하나인 셀룰로오스를 사용하기 위해 제지산업, 분리막, 보강재 등에 대한 연구가 진행되고 있다. 본 연구에서는 소비자 포장재, 자동차 산업 등 산업에서 가장 많이 쓰이고 있는 플라스틱 중 하나인 폴리프로필렌(polypropylene, PP)의 기계적 물성을 증가시키기 위해 셀룰로오스 나노 섬유(cellulose nanofiber, CNF)를 사용해 복합체를 제조했다. 무극성인 폴리프로필렌에 극성인 CNF를 분산시키기 위해 무수말레인산 폴리프로필렌(maleic anhydride polypropylene, MAPP)을 상용화제로 첨가했다. CNF가 첨가되면서 인장강도와 굴곡강도는 크게 향상됐으며 충격강도는 감소했다. SEM 분석 결과 PP/MAPP 매트릭스와 CNF 사이의 상호작용이 확인됐고 인장강도와 굴곡강도는 매트릭스와 CNF 간의 상호작용이 크게 작용해 증가한 반면 충격강도는 기공과 CNF로 인한 응력집중에 의해 감소함을 확인했다. TGA 분석결과 CNF가 열적으로 불안정하기 때문에 CNF의 함량이 증가할수록 복합체의 열적 안정도는 낮아졌다. 또한 높은 함량의 CNF 샘플에서 결합수로 인해 기공이 증가하는 현상을 관측했다.
BT8009; A Nectin-4 Targeting Bicycle Toxin Conjugate for Treatment of Solid Tumors (2022)

Multiple tumor types overexpress Nectin-4 and the antibody-drug conjugate (ADC), enfortumab vedotin (EV) shows striking efficacy in clinical trials for metastatic urothelial cancer, which expresses high levels of Nectin-4, validating Nectin-4 as a clinical target for toxin delivery in this indication. Despite excellent data in urothelial cancer, little efficacy data are reported for EV in other Nectin-4 expressing tumors and EV therapy can produce significant toxicities in many patients, frequently leading to discontinuation of treatment. Thus, additional approaches to this target with the potential to extend utility and reduce toxicity are warranted. We describe the preclinical development of BT8009, a "Bicycle Toxin Conjugate" (BTC) consisting of a Nectin-4-binding bicyclic peptide, a cleavable linker system and the cell penetrant toxin mono-methylauristatin E (MMAE). BT8009 shows significant antitumor activity in preclinical tumor models, across a variety of cancer indications and is well tolerated in preclinical safety studies. In several models, it shows superior or equivalent antitumor activity to an EV analog. As a small hydrophilic peptide-based drug BT8009 rapidly diffuses from the systemic circulation, through tissues to penetrate the tumor and target tumor cells. It is renally eliminated from the circulation, with a half-life of 1-2 hours in rat and non-human primate. These physical and PK characteristics differentiate BT8009 from ADCs and may provide benefit in terms of tumor penetration and reduced systemic exposure. BT8009 is currently in a Phase 1/2 multicenter clinical trial across the US, Canada, and Europe, enrolling patients with advanced solid tumors associated with Nectin-4 expression.
Novel Photonic Quantum Computing and Quantum Simulation (2015)

I will present experimental results for the superposition of quantum gates enabling significant computational speed-ups. I will also present the quantum simulation of two XY-interacting spins and discuss the current status of new photonic quantum technology.
Artificially Designed Membranes Using Phosphonated Multiwall Carbon Nanotube−Polybenzimidazole Composites for Polymer Electrolyte Fuel Cells (2010)

The ability of phosphonated carbon nanotubes to offer an unprecedented approach to tune both proton conductivity and mechanical stability of hybrid polymer electrolytes based on the polybenzimidazole membrane is demonstrated for fuel cell applications. The covalent attachment between the amino group of the 2-aminoethylphosphonic acid precursor and CNTs has been confirmed by NMR and IR experiments, while EDAX analysis indicates that one out of every 20 carbon atoms in the CNT is functionalized. Proton conductivity of the composite membrane shows a remarkable 50% improvement in performance, while a maximum power density of 780 and 600 mW cm−2 is obtained for the composite and pristine membranes, respectively. Finally, the ultimate strength determined for the composite and pristine membranes is 100 and 65 MPa, respectively, demonstrating the superiority of the composite. This study opens up a new strategy to systematically tune the properties of polymer electrolytes for special applications by using appropriately functionalized CNTs.
Angiotensin-II mediates norepinephrine and neuropeptide-Y secretion in a human pheochromocytoma (1994)

The potential role of angiotensin-II in mediating catecholamine and neuropeptide-Y release in a human pheochromocytoma has been investigated. Angiotensin-II type I receptors are transcribed and translated into functional proteins in a surgically removed pheochromocytoma. Primary cell culture of the tumor has been studied in a perfused system. Angiotensin-II increased the release of norepinephrine and neuropeptide-Y by the pheochromocytes. Activation of the angiotensin-II type I receptors by angiotensin-II was associated with a rise in cytosolic free calcium. The renin-angiotensin system may, therefore, contribute to the secretion of catecholamines and NPY occurring in patients with pheochromocytoma and when stimulated trigger hypertensive crisis.
Asian perspective on NAFLD-associated HCC (2021)

Recent data suggest that non-alcoholic fatty liver disease (NAFLD) has become a major public health problem in Asia, with an updated population prevalence of 34%. In parallel, NAFLD-associated hepatocellular carcinoma (HCC) is also on the rise. In this review, we describe the changing epidemiology of HCC in Asia over the past 30 years. While traditional risk factors for HCC (older age, male sex and metabolic factors) are also important in Asia, the PNPLA3 gene polymorphism is particularly prevalent in East Asia and may increase the risk of HCC. NAFLD among non-obese individuals is also commonly described in Asia. Because NAFLD is often undiagnosed, few patients receive HCC surveillance, and the target surveillance population beyond patients with cirrhosis remains poorly defined. As a result, NAFLD-associated HCC is often diagnosed at an advanced stage, rendering curative treatment impossible. Finally, despite around 20-30 years of universal vaccination, chronic HBV infection remains prevalent in Asia, and emerging evidence highlights the importance of metabolic factors and concomitant hepatic steatosis on HCC development in infected patients. Future studies should explore the role of metabolic treatments in HCC prevention among patients with hepatic steatosis and concomitant liver diseases.
ChemInform Abstract: Multiple Bonds Between Main‐Group Elements and Transition Metals. Part 71. Open‐Chain and Cyclic Organorhenium Complexes of π‐Aromatic Ligands: Oxygen‐, Sulfur‐, and Selenium‐Containing Derivatives. Strong Static trans Influence in the Crystal and Molecular Structure of Di‐μ‐sulfido‐bis(oxo(η5‐pentamethylcyclopentadienyl)rhenium(V)). (1990)

Abstract The key compound (II) is synthesized as shown in the scheme.
ChemInform Abstract: Atom‐Efficient Regioselective 1,2‐Dearomatization of Functionalized Pyridines by an Earth‐Abundant Organolanthanide Catalyst. (2015)

Abstract Cp*‐complexed lanthanum hydride dimer is used as catalyst in the 1,2‐selective hydroborylation of pyridines, quinoline and isoquinoline.
Freeway Performance Measurement System: Mining Loop Detector Data (2001)

Performance Measurement System (PeMS) is a freeway performance measurement system for all of California. It processes 2 GB/day of 30-s loop detector data in real time to produce useful information. At any time managers can have a uniform, comprehensive assessment of freeway performance. Traffic engineers can base their operational decisions on knowledge of the current status of the freeway network. Planners can determine whether congestion bottlenecks can be alleviated by improving operations or by minor capital improvements. Travelers can obtain the current shortest route and travel time estimates. Researchers can validate their theory and calibrate simulation models. PeMS, which has been in stable operation for 18 months, is a low-cost system. It uses the California Department of Transportation (Caltrans) network for data acquisition and is easy to deploy and maintain. It takes under 6 weeks to bring a Caltrans district online, and functionality can be added incrementally. PeMS applications are accessed over the World Wide Web; custom applications can work directly with the PeMS database. Built as a prototype, PeMS can be transitioned into a 7 × 24 production system. The PeMS architecture and use are described.
Optical design through optimization using freeform orthogonal polynomials for rectangular apertures (2015)

With the increasing interest in using freeform surfaces in optical systems due to the novel application opportunities and manufacturing techniques, new challenges are constantly emerging. Optical systems have traditionally been using circular apertures, but new types of freeform systems call for different aperture shapes. First non-circular aperture shape that one can be interested in due to tessellation or various folds systems is the rectangular one. This paper covers the comparative analysis of a simple local optimization of one design example using different orthogonalized representations of our freeform surface for the rectangular aperture. A very simple single surface off-axis mirror is chosen as a starting system. The surface is fitted to the desired polynomial representation, and the whole system is then optimized with the only constraint being the effective focal length. The process is repeated for different surface representations, amongst which there are some defined inside a circle, like Forbes freeform polynomials, and others that can be defined inside a rectangle like a new calculated Legendre type polynomials orthogonal in the gradient. It can be observed that with this new calculated polynomial type there is a faster convergence to a deeper minimum compared to “defined inside a circle” polynomials. The average MTF values across 17 field points also show clear benefits in using the polynomials that adapted more accurately to the aperture used in the system.
Pointing at Wiggle 3D Displays (2018)

This paper presents two new pointing techniques for wiggle 3D displays, which present the 2D projection of 3D content with automatic (rotatory) motion parallax. Standard pointing at targets in wiggle 3D displays is challenging as the content is constantly in motion. The two pointing techniques presented here take advantage of the cursor's current position or the user's gaze direction for collocating the wiggle rotation center and potential targets. We evaluate the performance of the pointing techniques with a novel methodology that integrates 3D distractors into the ISO-9241-9 standard task. The experimental results indicate that the new techniques are significantly more efficient than standard pointing techniques in wiggle 3D displays. Given that we observed no performance variation for different targets, our new techniques seem to negate any interaction performance penalties of wiggle 3D displays.
Simulation of the working range of an implantable hearing aid transducer by use of different piezoelectric materials (2015)

A piezoelectric membrane transducer which offers an approach to treat sensorineural hearing loss is introduced. The sensor and the actuator element each consist of a titanium membrane with a single crystal piezo and are clamped into the same assembly housing. The transducer is placed into the incudostapedial joint gap (between incus and stapes ossicle) which offers a straightforward implantation after the drilling of an access through a mastoidectomy which is state of the art for otology surgeries. The sensor is measuring the force transmitted through the ossicular chain onto his membrane on the incus-side of the housing. An associated signal processing drives the actuator at the opposite side of the sensor to amplify the movement transmitted by the ossicular chain to the inner ear. The movement of the stapes footplate is related to the hearing perception. Therefore the proposed concept can be used as part of a fully implantable hearing aid. A finite elemente model (FEM) of a transducer is built and implemented in a existing FEM model of the middle ear. Both sensor and actuator performance span up a working range for the transducer which ranges from about 20 to 30 dB SPL up to 90 to over 120 dB SPL. In this study the range of the workspace is evaluated in dependency of the chosen piezoelectric material which can lead to significant changes of the results.
Intrinsic viscosity of short-chain normal alkanes (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIntrinsic viscosity of short-chain normal alkanesR. K. Dewan, Victor A. Bloomfield, and Peter B. BergetCite this: J. Phys. Chem. 1971, 75, 20, 3120–3124Publication Date (Print):September 1, 1971Publication History Published online1 May 2002Published inissue 1 September 1971https://pubs.acs.org/doi/10.1021/j100689a015https://doi.org/10.1021/j100689a015research-articleACS PublicationsRequest reuse permissionsArticle Views133Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
High-precision Measurement of the Radiation Patterns of Small Antennas by an S-Parameter Method Using a Photodiode Module (2022)

This paper proposes an S-parameter method using a small PhotoDiode module for improving precision of radiation pattern measurement. The effects of structure for measurement are reduced compared to the measurement system with the conventional method by using the RF cable of the minimum necessary length and the PhotoDiode module. We verify the effectiveness of the proposed method by the measurement of a small bent monopole antenna.
Clinical Development of 2B1, a Bispecific Murine Monoclonal Antibody Targeting c-erbB-2 and FcγRIII (1995)

Bispecific monoclonal antibodies (BsmAb) can be used to specifically target tumor cells for cytotoxicity mediated by defined effector cells. One such BsmAb, 2B1, targets the extracellular domains of both the c-erbB-2 protein product of the HER-2/neu oncogene and Fc gamma RIII (CD16), the Fc gamma receptor expressed by human natural killer cells, neutrophils, and differentiated mononuclear phagocytes. 2B1 promotes the conjugation of cells expressing these target antigens. It efficiently promotes the specific lysis of tumor cells expressing c-erbB-2 by human NK cells and macrophages over a broad concentration range. 2B1 selectively targets c-erbB-2-positive human tumor xenografts growing in immunodeficient SCID mice. Treatment of such mice with 2B1 plus interleukin 2 (IL-2) inhibits the growth of early, established human tumor xenografts overexpressing c-erbB-2. A phase I clinical trial of 2B1 has been initiated to determine the toxicity profile and maximum tolerated dose (MTD) of this BsmAb and to examine the biodistribution of the antibody and the biologic effects of treatment. Preliminary results of this trial indicate that the dose-limiting toxicity for patients with extensive prior bone marrow-toxic therapy is thrombocytopenia for as yet undetermined reasons. Toxicities of fevers, rigors, and associated constitutional symptoms are explained, in part, by treatment-induced systemic expression of cytokines, such as tumor necrosis factor-alpha. Circulating, functional BsmAb is easily detectible in treatment patients' sera and exhibits complex elimination patterns. HAMA and anti-idiotypic treatment-induced antibodies are induced by 2B1 treatment. Some preliminary indications of clinical activity have been observed. BsmAb therapy targeting tumor antigens and Fc gamma RIII has potent immunologic effects. Future studies will include the development of more relevant animal models for BsmAb therapy targeting human Fc gamma RIII. The ongoing phase I trial will be completed to identify the MTD for patients without extensive prior bone marrow-toxic chemotherapy and radiation. A phase II clinical trial of 2B1 therapy in women with metastatic breast cancer is planned, as is a phase I trial incorporating treatment with both 2B1 and IL-2.
Targeted Control of Kinetics of β-Amyloid Self-association by Surface Tension-modifying Peptides (2003)

Brain tissue from Alzheimer's patients contains extracellular senile plaques composed primarily of deposits of fibrillar aggregates of beta-amyloid peptide. beta-Amyloid aggregation is postulated to be a major factor in the onset of this neurodegenerative disease. Recently proposed is the hypothesis that oligomeric intermediates, rather than fully formed insoluble fibrils, are cytotoxic. Previously, we reported the discovery of peptides that accelerate beta-amyloid aggregation yet inhibit toxicity in vitro, in support of this hypothesis. These peptides contain two domains: a recognition element designed to bind to beta-amyloid and a disrupting element that alters beta-amyloid aggregation kinetics. Here we show that the aggregation rate-enhancing activity of the disrupting element correlates strongly with its ability to increase surface tension of aqueous solutions. Using the Hofmeister series as a guide, we designed a novel peptide with terminal side-chain trimethylammonium groups in the disrupting domain. The derivatized peptide greatly increased solvent surface tension and accelerated beta-amyloid aggregation kinetics by severalfold. Equivalent increases in surface tension in the absence of a recognition domain had no effect on beta-amyloid aggregation. These results suggest a novel strategy for targeting localized changes in interfacial energy to specific proteins, as a way to selectively alter protein folding, stability, and aggregation.