gebhart/patrepeval huggingface dataset:
Design of High-Precision ROIC for Quantum Dot Infrared Photodetector (2016)

Read out integrated circuit (ROIC) design for quantum dot infrared photodetector (QDIP) array requires large charge handling capacity, low readout noise, minimum detector bias voltage variations, and minimum power dissipation. ROIC design for such applications is challenging due to complex requirements and often needs iterative fabrications to meet all requirements. In this letter, we propose a decision matrix-based optimization method for large dynamic range ROIC implementation. The optimization method is based on trade off analysis, design, and simulation of identified ROIC parameters. This methodology has been applied to an actual case, and the optimum ROIC topology was selected using the optimization method described in this letter. The critical specifications are charge handling capacity of greater than 5 <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\text{M}\overline {e}$ </tex-math></inline-formula> and low readout noise of less than 600 electrons, in 180-nm CMOS process. The large dynamic range ROIC consists of a charge integration stage, charge to voltage converters, correlated double samplers, sample and holds, column amplifiers, analog multiplexer, and a buffer amplifier stage. This letter also highlights the measured test chip results of an ROIC array of 30 <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\mu \textrm {m} \times 30~\mu \text{m}$ </tex-math></inline-formula> pixel size, in which we have been able to achieve a charge handling capacity of 9.8 <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\text{M}\overline {e}$ </tex-math></inline-formula> and the noise of 350 electrons.
A novel Polish presenilin-1 mutation (P117L) is associated with familial Alzheimerʼs disease and leads to death as early as the age of 28 years (1998)

The majority of early-onset familial Alzheimer's disease (FAD) is associated with mutations in the presenilin-1 (PS1) gene. We describe a novel Polish PS1 mutation of Pro117Leu, associated with the earliest average age of onset and death so far reported in a PS-linked, FAD kindred. Human kidney 293 and mouse neuroblastoma N2a cells were stably transfected with wild-type and PS1 P117L. There was a significant increase in the amyloid beta42/40 ratio in the N2a P117L PS1 transfected cells compared with N2a transfected with wild-type PS1. What role PS has in the pathogenesis of AD remains to be determined, however, the severity of the clinical picture associated with this PS1 mutation stresses the importance of presenilin.
Smooth incidence maps give valuable insight into Q fever outbreaks in The Netherlands (2012)

From 2007 through 2009, The Netherlands faced large outbreaks of human Q fever. Control measures focused primarily on dairy goat farms because these were implicated as the main source of infection for the surrounding population. However, in other countries, outbreaks have mainly been associated with non-dairy sheep and The Netherlands has many more sheep than goats. Therefore, a public discussion arose about the possible role of non-dairy (meat) sheep in the outbreaks. To inform decision makers about the relative importance of different infection sources, we developed accurate and high-resolution incidence maps for detection of Q fever hot spots. In the high incidence area in the south of the country, full postal codes of notified Q fever patients with onset of illness in 2009, were georeferenced. Q fever cases (n = 1,740) were treated as a spatial point process. A 500 x 500 m grid was imposed over the area of interest. The number of cases and the population number were counted in each cell. The number of cases was modelled as an inhomogeneous Poisson process where the underlying incidence was estimated by 2-dimensional P-spline smoothing. Modelling of numbers of Q fever cases based on residential addresses and population size produced smooth incidence maps that clearly showed Q fever hotspots around infected dairy goat farms. No such increased incidence was noted around infected meat sheep farms. We conclude that smooth incidence maps of human notifications give valuable information about the Q fever epidemic and are a promising method to provide decision support for the control of other infectious diseases with an environmental source.
Integrated ceramic temperature sensors for harsh environments (2006)

In this paper, ceramic thermocouples prepared with ITO (indium-tin-oxide) thermoelements having very different charge carrier concentrations were demonstrated in both open flame burner rig tests and furnace tests at temperatures approaching 1250/spl deg/C. Ceramic RTDs (resistance temperature detectors) based on ITO were also thermally cycled in various oxygen partial pressures and the resulting temperature coefficients of resistance were stable and nearly independent of oxygen partial pressure at temperatures above 700/spl deg/C. Based on these results, a multifunctional sensor has been developed which incorporates a ceramic RTD, a ceramic strain sensor and a ceramic thermocouple on a common substrate.
All-focused light field rendering (2004)

We present a novel reconstruction method that can synthesize an all in-focus view from under-sampled light fields, significantly suppressing aliasing artifacts. The presented method consists of two steps; 1) rendering multiple views at a given view point by performing light field rendering with different focal plane depths; 2) iteratively reconstructing the all in-focus view by fusing the multiple views. We model the multiple views and the desired all in-focus view as a set of linear equations with a combination of textures at the focal depths. Aliasing artifacts can be modeled as spatially (shift) varying filters. We can solve this set of linear equations by using an iterative reconstruction approach. This method effectively integrates focused regions in each view into an all in-focus view without any local processing steps such as estimation of depth or segmentation of the focused regions.
Boosting ion dynamics through superwettable leaf-like film based on porous g-C3N4 nanosheets for ionogel supercapacitors (2019)

Abstract Ionic liquid (IL) electrolytes have enormous potential for the development of high energy density supercapacitors (SCs) owing to their wide potential windows, but ILs are plagued by sluggish ionic diffusion due to their high viscosity and large ion size. Exploiting superwettable electrodes possessing high compatibility with IL electrolytes remains challenging. Inspired by the biological characteristics observed in nature, a unique film electrode with a Monstera leaf-like nanostructure is synthesized and used to overcome the aforementioned bottleneck. Similar to the pores in Monstera leaves that allow the permeation of air and water vapor, the film electrode is based on porous g -C 3 N 4 nanosheets (~1 nm thick) as ion-accessible “highway” channels, allowing ultrafast diffusion of IL ions. The film exhibits a high diffusion coefficient (3.68 × 10 −10 m 2 s −1 ), low activation energy (0.078 mJ mol −1 ) and extraordinary wettability in the IL electrolyte, indicating its superior IL ion dynamics. As a proof of concept, flexible ionogel SCs (FISCs) with tailorability and editability are fabricated, which exhibit a high energy density (10.5 mWh cm −3 ), high-power density, remarkable rate capability, and long-term durability, outperforming previously reported FISCs. Importantly, these FISCs can be effectively charged by harvesting sustainable power sources, particularly the rarely studied wind power, for practical applications.
Comparison of long‐term clinical outcomes in multivessel coronary artery disease patients treated either with bioresoarbable polymer sirolimus‐eluting stent or permanent polymer everolimus‐eluting stent: 5‐year results of the CENTURY II randomized clinical trial (2019)

These results confirm good long-term safety and efficacy of the studied bioresorbable polymer stent in this high-risk patient population.
Human Adenovirus Type 26 Induced IL-6 Gene Expression in an αvβ3 Integrin- and NF-κB-Dependent Manner (2022)

The low seroprevalent human adenovirus type 26 (HAdV26)-based vaccine vector was the first adenovirus-based vector to receive marketing authorization from European Commission. HAdV26-based vaccine vectors induce durable humoral and cellular immune responses and, as such, represent a highly valuable tool for fighting infectious diseases. Despite well-described immunogenicity in vivo, the basic biology of HAdV26 still needs some refinement. The aim of this study was to determine the pro-inflammatory cytokine profile of epithelial cells infected with HAdV26 and then investigate the underlying molecular mechanism. The expression of studied genes and proteins was assessed by quantitative polymerase chain reaction, western blot, and enzyme-linked immunosorbent assay. Confocal microscopy was used to visualize HAdV26 cell uptake. We found that HAdV26 infection in human epithelial cells triggers the expression of pro-inflammatory cytokines and chemokines, namely IL-6, IL-8, IL-1β, and TNF-α, with the most pronounced difference shown for IL-6. We investigated the underlying molecular mechanism and observed that HAdV26-induced IL-6 gene expression is αvβ3 integrin dependent and NF-κB mediated. Our findings provide new data regarding pro-inflammatory cytokine and chemokine expression in HAdV26-infected epithelial cells, as well as details concerning HAdV26-induced host signaling pathways. Information obtained within this research increases our current knowledge of HAdV26 basic biology and, as such, can contribute to further development of HAdV26-based vaccine vectors.
Architecture of a Reusable BIST Engine for Detection and Autocorrection of Memory Failures and for IO Debug, Validation, Link Training, and Power Optimization on 14-nm SoC (2015)

This paper presents the hardware and software architecture of a reusable BIST engine for 3D stacked 14-nm SoC, which also includes software-assisted autorepair of memory defects. Silicon results presented demonstrate the features of such engine such as easy silicon debug, validation time reduction by 3x, detection and repair of memory cell defects, etc. This solution has been successfully designed and used for seven Intel SoCs successfully debugged, tested, and launched into the market place.
Large Area Liquid Crystal Monodomain Field-Effect Transistors (2006)

Butyl, hexyl, and decyl derivatives of the liquid-crystalline organic semiconductor 5,5' '-bis(5-alkyl-2-thienylethynyl)-2,2':5',2' '-terthiophene were synthesized and studied with respect to their structural, optical, and electrical properties. By means of an optimized thermal annealing scheme the hexyl and decyl compounds could be processed into self-assembled monodomain films of up to 150 mm in diameter. These were investigated with X-ray diffractometry, which revealed a clearly single-crystalline monoclinic morphology with lamellae parallel to the substrate. Within the lamellae the molecules were found to arrange with a tilt of about 50 degrees with the rubbing direction of the polyimide alignment layer. The resulting, close side-to-side packing was confirmed by measurements of the UV/vis absorption, which showed a dichroic ratio of 19 and indicated H-aggregation. AFM analyses revealed self-affinity in the surface roughness of the monodomain. The compounds showed bipolar charge transport in TOF measurements, with hole mobilities reaching up to 0.02 cm(2)/Vs and maximum electron mobilities around 0.002 cm(2)/Vs. The hexyl derivative was processed into large-area monodomain top-gate field-effect transistors, which were stable for months and showed anisotropic hole mobilities of up to 0.02 cm(2)/Vs. Compared to multidomain bottom-gate transistors the monodomain formation allowed for a mobility increase by 1 order of magnitude.
On amplitude-gain-control optimization for Lissajous frequency modulated MEMS gyroscopes (2021)

This work discusses the peculiar needs of amplitude-gain-control (AGC) loops in oscillators for Lissajous frequency modulated gyroscopes. After comparing possible implementations, a novel dual-mode architecture is disclosed, to simultaneously enable a fast start-up and no relevant distortion of the intended proof mass trajectory. Experimental results on an integrated 50-kHz frequency-modulated gyroscope confirm a start-up time of about 100 ms, with minimized control errors and without any noise worsening.
Systematic Development of a New Variational Autoencoder Model Based on Uncertain Data for Monitoring Nonlinear Processes (2019)

Deep learning models have been applied to industrial process fault detection because of their ability to approximate the complex nonlinear behavior. They have been proven to outperform the shallow neural network models. However, there are no good guidelines on how to build these deep models. Therefore, a good deep model is often constructed through a trial-and-error exercise. It is not easy to interpret the model because of features that do not have any physical interpretation. In addition, latent variables (or features) in a deep model are not independent. This causes features to overlap with each other, resulting in challenges in evaluating distributions of features and designing suitable monitoring indices. Finally, typical deep learning models in process monitoring are used in a deterministic manner and do not automatically provide confidence levels for each decision. In this paper, a variational autoencoder is utilized to develop a framework for monitoring uncertain nonlinear processes. The learned latent variables are guaranteed to be independent (or orthogonal) of each other under a specific optimization objective with constraints. The proposed method provides the density estimates of latent variables and residuals instead of point estimates. The density functions are used to design appropriate indices for monitoring. A simulation example and an industrial paper machine example are presented to validate the effectiveness of the proposed method.
Development of Power Assist Crane Operated by Tensional Information of Dual Wire (2013)

Cranes and hoists at automotive assembly plant handle heavy objects such as batteries to decrease the physical burden on personnel. On/off button operations in such devices during fine positioning increase personnel mental stress. On the other hand, in power assist using force sensors which directly measure operating force, maneuverability is improved but we should be concerned about sensor weight, signal wiring, wire breakage and so on. Therefore, in this study, a power assist system driven by two wires is developed to improvemaneuverability andmaintenance. The method we propose estimates operating force and work load from tensional information on wires and controls the position of work by admittance control. The effectiveness of the proposed method is shown from confirmation and power assist experiments.
Multiwavelength Erbium-Doped Fiber Ring Laser Employing Fabry-Perot Etalon (2009)

We propose a multiwavelength erbium-doped fiber (EDF) ring laser using a Fabry-Perot etalon inside the ring cavity with optimal fiber length to satisfy the least common multiple number for generating multiwavelength at room temperature.
Central somatostatin receptor 1 activation reverses acute stress-related alterations of gastric and colonic motor function in mice (2011)

The stress of acute anesthesia/vehicle i.c.v. injection reduced GE by 67% and increased defecation by 99% compared to non-injected controls. Both responses were abolished by ODT8-SST (1μg= 0.75nmol) or sst(1) agonist (0.65-1.95nmol). The sst(1) agonist (1.95nmol) also prevented the abdominal surgery-induced delayed GE. Octreotide (sst(2) >sst(5) > sst(3) ) and the sst(2) or sst(4) agonists (1μg=0.78 or 0.70nmol, respectively) injected i.c.v. did not influence FPO while i.c.v. somatostatin-28 mimicked ODT8-SST's effect. The ODT8-SST-induced increased food intake was inhibited by i.c.v. sst(2) antagonist while the reduced FPO was unchanged. ODT8-SST i.c.v. reduced distal colonic motility in semi-restrained mice compared with vehicle and blocked water avoidance- and i.c.v. CRF (0.5μg=0.09nmol)-induced stimulated FPO while a similar colonic secretomotor response to i.p. 5-hydroxytryptophane (10mgkg(-1) =36.4μmol kg(-1) ) was unaltered. Conclusions & Inferences ODT8-SST counteracts stress/i.c.v. CRF-related stimulation of colonic motor function and delayed GE which can be reproduced mainly by activation of sst(1) receptors. These data opens new insight to brain somatostatinergic signaling pathways interfering with brain circuitries involved in gut motor responses to acute stress.
ChemInform Abstract: A Novel Radical Reaction of Alkyl Xanthates Useful for the Selective Substitution of Heteroaromatic Bases. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Combined estimation and control of HMMs (2002)

The principal contribution of this paper is the presentation of the potential theoretical results that are needed for an application of stochastic approximation theory to the problem of demonstrating asymptotic stability for combined estimation and control of a plant described by a hidden Markov model. We motivate the results by briefly describing a combined estimation and control problem. We show how the problem translates to the stochastic approximation framework. We also show how the Markov chain that underlies the stochastic approximation problem can be decomposed into factors with discrete and continuous range. Finally, we use this decomposition to develop the results that are needed for an application of the ODE method to the stochastic control problem.
Fabrication of Arbitrarily Narrow Vertical Dielectric Slots in Silicon Waveguides (2017)

Slot waveguides are used for many photonic applications. However, existing fabrication techniques impose restrictions on the width of the slot region. Here, we propose and experimentally demonstrate a fabrication process to realize an arbitrarily narrow vertical dielectric slot in a silicon waveguide. Using this fabrication method, we have realized silicon slot waveguides with a 10-nm oxide slot region. The propagation loss of the fabricated slot waveguide was 1.36 ± 0.3 dB/mm.
Radially Oscillating Flow Hybrid Cooling System for Low Profile Electronics Applications (2008)

The radially oscillating flow hybrid cooling system, in the following referred to as RADIOS, provides a thin form factor cold plate with radial spreading of heat to a larger area. A small liquid volume (<10 ml) is hermetically sealed within the system and does not require external hose connections. Four membrane pumps running in a phase-delayed manner induce a constant-speed, oscillating direction fluid flow at the chip source that continuously shuttles heat to an extended periphery and returns cool liquid to the chip. In the peripheral branches, heat is transferred from the liquid to solid structures and finally dissipated to the air. A micro-scale copper mesh enables low-resistance heat transfer (solid-liquid and liquid- solid) in a thin form factor (< 2 mm). Narrow channels between the discrete heat exchanger areas optimize the spreading performance and reduce the fluid volume. Numerical modeling shows an effective conductivity of 20X and 50X over bulk copper for the spreader plates and the interconnecting tubes, respectively. The technology presented here promotes modular liquid cooling units for low-profile computing systems without incurring the risk of flooding associated with conventional liquid cooling circuits.
The Cytoprotective Enzyme Heme Oxygenase-1 Suppresses Ebola Virus Replication (2013)

Ebola virus (EBOV) is the causative agent of a severe hemorrhagic fever in humans with reported case fatality rates as high as 90%. There are currently no licensed vaccines or antiviral therapeutics to combat EBOV infections. Heme oxygenase-1 (HO-1), an enzyme that catalyzes the rate-limiting step in heme degradation, has antioxidative properties and protects cells from various stresses. Activated HO-1 was recently shown to have antiviral activity, potently inhibiting the replication of viruses such as hepatitis C virus and human immunodeficiency virus. However, the effect of HO-1 activation on EBOV replication remains unknown. To determine whether the upregulation of HO-1 attenuates EBOV replication, we treated cells with cobalt protoporphyrin (CoPP), a selective HO-1 inducer, and assessed its effects on EBOV replication. We found that CoPP treatment, pre- and postinfection, significantly suppressed EBOV replication in a manner dependent upon HO-1 upregulation and activity. In addition, stable overexpression of HO-1 significantly attenuated EBOV growth. Although the exact mechanism behind the antiviral properties of HO-1 remains to be elucidated, our data show that HO-1 upregulation does not attenuate EBOV entry or budding but specifically targets EBOV transcription/replication. Therefore, modulation of the cellular enzyme HO-1 may represent a novel therapeutic strategy against EBOV infection.
Cyclopropane fatty acids are involved in organic solvent tolerance but not in acid stress resistance in Pseudomonas putida DOT‐T1E (2009)

Bacterial membranes constitute the first physical barrier against different environmental stresses. Pseudomonas putida DOT-T1E accumulates cyclopropane fatty acids (CFAs) in the stationary phase of growth. In this strain the cfaB gene encodes the main cyclopropane synthase responsible of the synthesis of CFAs, and its expression is mediated by RNA polymerase with sigma factor σ(38). We generated a cfaB mutant of P. putida DOT-T1E and studied its response to solvents, acid pH and other stress conditions such as temperature changes, high osmolarity and the presence of antibiotics or heavy metals in the culture medium. A CfaB knockout mutant was more sensitive to solvent stress than the wild-type strain, but in contrast to Escherichia coli and Salmonella enterica, the P. putida cfaB mutant was as tolerant to acid shock as the wild-type strain. The cfaB mutant was also as tolerant as the parental strain to a number of drugs, antibiotics and other damaging agents.