gebhart/patrepeval huggingface dataset:
Adaptation Opportunities, Constraints, and Limits (2015)

Since the IPCC's Fourth Assessment Report (AR4), demand for knowledge regarding the planning and implementation of adaptation as a strategy for climate risk management has increased significantly (Preston et al., 2011a; Park et al., 2012). This chapter assesses recent literature on the opportunities that create enabling conditions for adaptation as well as the ancillary benefits that may arise from adaptive responses. It also assesses the literature on biophysical and socioeconomic constraints on adaptation and the potential for such constraints to pose limits to adaptation. Given the available evidence of observed and anticipated limits to adaptation, the chapter also discusses the ethical implications of adaptation limits and the literature on system transformational adaptation as a response to adaptation limits.\n\nTo facilitate this assessment, this chapter provides an explicit framework for conceptualizing opportunities, constraints, and limits (Section 16.2). In this framework, the core concepts including definitions of adaptation, vulnerability, and adaptive capacity are consistent with those used previously in the AR4 (Adger et al., 2007). However, the material in this chapter should be considered in conjunction with that of complementary WGII AR5 chapters. These include Chapter 14 (Adaptation Needs and Options), Chapter 15 (Adaptation Planning and Implementation), and Chapter 17 (Economics of Adaptation). Material from other WGII AR5 chapters is also relevant to informing adaptation opportunities, constraints, and limits, particularly Chapter 2 (Foundations for Decision Making) and Chapter 19 (Emergent Risks and Key Vulnerabilities). This chapter also synthesizes relevant material from each of the sectoral and regional chapters (Section 16.5).\n\nTo enhance its policy relevance, this chapter takes as its entry point the perspective of actors as they consider adaptation response strategies over near, medium, and longer terms (Eisenack and Stecker, 2012; Dow et al., 2013a,b). Actors may be individuals, communities, organizations, corporations, non-governmental organizations (NGOs), governmental agencies, or other entities responding to real or perceived climate-related stresses or opportunities as they pursue their objectives (Patt and Schröter, 2008; Blennow and Persson, 2009; Frank et al., 2011).
D6.6 Final report on the METIS 5G system concept and technology roadmap (2014)

This deliverable presents the METIS 5G system concept which was developed to fulfil the &#13;\nrequirements of the beyond-2020 connected information society and to extend today’s &#13;\nwireless communication systems to include new usage scenarios. &#13;\nThe METIS 5G system concept consists of three generic 5G services and four main enablers. &#13;\nThe three generic 5G services are Extreme Mobile BroadBand (xMBB), Massive Machine-&#13;\nType Communications (mMTC), and Ultra-reliable Machine-Type Communication (uMTC). &#13;\nThe four main enablers are Lean System Control Plane (LSCP), Dynamic RAN, Localized &#13;\nContents and Traffic Flows, and Spectrum Toolbox.&#13;\nAn overview of the METIS 5G architecture is given, as well as spectrum requirements and &#13;\nconsiderations.&#13;\nSystem-level evaluation of the METIS 5G system concept has been conducted, and we conclude that the METIS technical objectives are met.&#13;\nA technology roadmap outlining further 5G development, including a timeline and recommended future work is given.
Multi-species gas detection and precise line area measurements using CRDS and a high-precision wavemeter (2007)

We demonstrate precise measurement of absorption line width made possible with a high-precision wavelength monitor, enabling the determination of species concentration from the line area. We also demonstrate simultaneous measurement of multiple species concentrations.
Electron-Transfer Reactions of fluorofullerene C60F48 (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectron-Transfer Reactions of fluorofullerene C60F48Feimeng Zhou, Gary J. Van Berkel, and Bernadette T. DonovanCite this: J. Am. Chem. Soc. 1994, 116, 12, 5485–5486Publication Date (Print):June 1, 1994Publication History Published online1 May 2002Published inissue 1 June 1994https://doi.org/10.1021/ja00091a069RIGHTS & PERMISSIONSArticle Views289Altmetric-Citations83LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (303 KB) Get e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Perfusion techniques during surgery of the thoracic and thoraco-abdominal aorta: the veno-arterial bypass (2007)

Open repair of the descending thoracic aorta and the thoraco-abdominal aorta remains a challenging procedure. On the proximal side, pressure overload in the supra-aortic territories and pump failure are just two examples for undesirable effects of descending thoracic aortic cross-clamping which may end with a disaster. On the distal side, potential problems include among others, paraplegia, renal failure, visceral and peripheral ischemia. Finally, there are per-procedural issues like hypoxia due to single lung ventilation, uncontrollable inflow or backflow, excessive blood loss, unrealistic time constraints for systematic revascularization of intercostals arteries etc. Partial (femoro-femoral) cardiopulmonary bypass provides answers to many of the issues raised above. In addition, perfusion with heparin coated equipment allowing for significant reduction of anticoagulation has been shown to be useful for maintaining the hemostatic potential of the patient and limiting blood loss. Our current approach to perfusion for descending thoracic and thoraco-abdominal aneurysm repair has evolved into a versatile cardiopulmonary bypass strategy allowing for rapid conversion from partial cardiopulmonary bypass with peripheral cannulation to full, and if necessary, central, cardiopulmonary bypass, and all sorts of combinations including deep hypothermic circulatory arrest.
Anti-reovirus receptor antibody accelerates expression of the optic nerve oligodendrocyte developmental program. (1991)

Previous studies showed that the cell-surface receptor for reovirus serotype 3 (Reo3R) appears at an early stage of oligodendrocyte differentiation and that anti-Reo3R antibodies and Reo3R-binding peptides induce galactocerebroside expression by developing oligodendrocytes. In the present studies, anti-Reo3R antibodies are shown to stimulate additional features of the program of oligodendrocyte development, including the loss of the A2B5 marker and expression of myelin basic protein. In anti-Reo3R antibody-treated cultures, galactocerebroside was expressed by cells having the morphology of immature oligodendrocyte precursors. Reo3R binding did not appear directly to inhibit or stimulate proliferation of glial progenitor cells or to affect their lineage commitment. Cell-surface structures utilized as a receptor by reovirus type 3 appear to play a role in the regulation of the initiation or rate of execution of the oligodendrocyte developmental program.
Harnessing Numerical Flexibility for Deep Learning on FPGAs (2018)

Deep learning has become a key workload in the data centre and edge leading to an arms race for compute dominance in this space. FPGAs have shown they can compete by combining deterministic low-latency with high throughput and flexibility. In particular, due to FPGAs' bit-level programmability, FPGAs can efficiently implement arbitrary precisions and numeric data types which is critical to fast evolving fields like deep learning.
Characterization of pore structure changes during gasification (1985)

Small angle x-ray scattering (SAXS) has been used to monitor changes in the internal structure of carbonaceous material during gasification. The technique has the advantage of being nonintrusive and offering the potential for measurements at gasification conditions. The interpretation of SAXS data and associated evolution of surface areas and pore size distribution is discussed in terms of different modeling options.
Synthesis and Structure−Activity Relationships of 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]pyridine Analogues as Potent, Noncompetitive Metabotropic Glutamate Receptor Subtype 5 Antagonists; Search for Cocaine Medications (2006)

Recent genetic and pharmacological studies have suggested that the metabotropic glutamate receptor subtype 5 (mGluR5) may represent a druggable target in identifying new therapeutics for the treatment of various central nervous system disorders including drug abuse. In particular, considerable attention in the mGluR5 field has been devoted to identifying ligands that bind to the allosteric modulatory site, distinct from the site for the primary agonist glutamate. Both 2-methyl-6-(phenylethynyl)pyridine (MPEP) and its analogue 3-[(2-methyl-4-thiazolyl)ethynyl]pyridine (MTEP) have been shown to be selective and potent noncompetitive antagonists of mGluR5. Because of results presented in this study showing that MTEP prevents the reinstatement of cocaine self-administration caused by the presentation of environmental cues previously associated with cocaine availability, we have prepared a series of analogues of MTEP with the aim of gaining a better understanding of the structural features relevant to its antagonist potency and with the ultimate aim of investigating the effects of such compounds in blunting the self-administration of cocaine. These efforts have led to the identification of compounds showing higher potency as mGluR5 antagonists than either MPEP or MTEP. Two compounds 19 and 59 exhibited functional activity as mGluR5 antagonists that are 490 and 230 times, respectively, better than that of MTEP.
Three-dimensional phase optical transfer function in axially symmetric microscopic quantitative phase imaging (2020)

Three-dimensional quantitative phase imaging (3D QPI) is widely recognized as a potentially high-impact microscopic modality. Central to determining the resolution capability of 3D QPI is the phase optical transfer function (POTF). The magnitude of the POTF over its spatial frequency coverage (SFC) specifies the intensity of the response for each allowed spatial frequency. In this paper, a detailed analysis of the POTF for an axially symmetric optical configuration is presented. First, a useful geometric interpretation of the SFC, which enables its visualization, is presented. Second, a closed-form 1D integral expression is derived for the POTF in the general nonparaxial case, which enables rapid calculation of the POTF. Third, this formulation is applied to disk, annular, multi-annuli, and Gaussian illuminations as well as to an annular objective. Taken together, these contributions enable the visualization and simplified calculation of the 3D axially symmetric POTF and provide a basis for optimizing QPI in a wide range of applications.
Real-Time Depth Monitoring of Galvo-telecentric Laser Machining by Inline Coherent Imaging (2013)

We achieve in situ, micron-scale tracking of laser machining through a galvo-telecentric beam delivery system using coherent imaging. We collect both high speed intrapulse and interpulse morphology changes as well as overall sweep-to-sweep depth penetration.
ChemInform Abstract: Fluorous‐Tethered Quenching Reagents for Solution Phase Parallel Synthesis. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Activation of c-fos Gene Expression by a Kinase-Deficient Epidermal Growth Factor Receptor (1994)

The intrinsic tyrosine kinase activity of the epidermal growth factor receptor (EGFR) has been shown to be responsible for many of the pleiotropic intracellular effects resulting from ligand stimulation [W.S. Chen, C.S. Lazar, M. Poenie, R.Y. Tsien, G.N. Gill, and M.G. Rosenfeld, Nature (London) 328:820-823, 1987; A.M. Honegger, D. Szapary, A. Schmidt, R. Lyall, E. Van Obberghen, T.J. Dull, A. Ulrich, and J. Schlessinger, Mol. Cell. Biol. 7:4568-4571, 1987]. Recently, however, it has been shown that addition of ligand to cells expressing kinase-defective EGFR mutants can result in the phosphorylation of mitogen-activated protein kinase (R. Campos-González and J.R. Glenney, Jr., J. Biol. Chem. 267:14535-14538, 1992; E. Selva, D.L. Raden, and R.J. Davis, J. Biol. Chem. 268:2250-2254, 1993), as well as stimulation of DNA synthesis (K.J. Coker, J.V. Staros, and C.A. Guyer, Proc. Natl. Acad. Sci. USA 91:6967-6971, 1994). Moreover, mitogen-activated protein kinase has been shown to phosphorylate the transcription factor p62TCF in vitro, leading to enhanced ternary complex formation between p62TCF, p67SRF, and the c-fos serum response element (SRE) [H. Gille, A.D. Sharrocks, and P.E. Shaw, Nature (London) 358:414-417, 1992]. On the basis of these observations, we have investigated the possibility that the intrinsic tyrosine kinase activity of the EGFR may not be necessary for transcriptional activation mediated via p62TCF. Here, we demonstrate that a kinase-defective EGFR mutant can signal ligand-induced expression of c-fos protein and that a significant component of this induction appears to be mediated at the transcriptional level. Investigation of transcriptional activation mediated by the c-fos SRE shows that this response is impaired by mutations in the SRE which eliminate binding of p62(TCF). These data indicate that information inherent in the structure of the EGFR can be accessed by ligand stimulation independent of the receptor's catalytic kinase function.
WT1 vaccination in AML and MDS: A pilot trial with synthetic analog peptides (2015)

Peptide vaccines are capable of eliciting immune responses targeting tumor-associated antigens such as the Wilms' Tumor 1 (WT1) antigen, often overexpressed in myeloid malignancies. Here, we assessed the safety, tolerability, and immunogenicity of a polyvalent WT1 peptide vaccine. Individuals with WT1-positive acute myeloid leukemia (AML) in first (CR1) or second (CR2) remission or with higher-risk myelodysplastic syndrome (MDS) following at least 1 prior line of therapy were vaccinated with a mixture of peptides derived from the WT1 protein, with sargramostim injections before vaccination to amplify immunogenicity. Six vaccinations were delivered biweekly, continuing then monthly until patients received 12 vaccinations or showed disease relapse or progression. Therapeutic efficacy was evaluated by progression-free and overall survival. Immune responses were evaluated by delayed-type hypersensitivity testing and T-cell IFNγ ELISPOT at specified intervals. In 16 patients who received at least one vaccination, 10 completed the planned course of six vaccinations and six continued for up to six additional monthly vaccinations. Vaccinations were well tolerated, with no patients discontinuing due to toxicity. One of two patients with high-risk MDS experienced a prolonged decrease in transfusion dependence. Two of 14 AML patients demonstrated relapse-free survival >1 year. Both patients were in CR2 at time of vaccination, with duration of their remission exceeding duration of their first remission, suggesting a potential benefit. Our WT1 vaccine was well-tolerated. The clinical benefit that we observed in several patients suggests engagement of a protective immune response, indicating a need for further trials.
Evidence that levels of nine essential metals in post-mortem human-Alzheimer’s-brain andex vivorat-brain tissues are unaffected by differences in post-mortem delay, age, disease staging, and brain bank location (2020)

Studies of neurodegenerative conditions such as Alzheimer's disease (AD) using post mortem brain tissues have uncovered several perturbations in metals such as copper, iron, and zinc. However, studies of the effects of key, potentially confounding variables on these tissues are currently lacking. Moreover, human-brain tissues have limited availability, further enhancing the difficulty of matching potentially-significant variables including age, sex-matching, post-mortem delay (PMD), and neuropathological stage. This study aimed to investigate the effects of such factors and how they might influence metal concentrations in post-mortem brains. Cingulate gyrus from AD cases and matched controls was obtained from two brain banks, based in Auckland, New Zealand and Manchester, UK. Inductively-coupled plasma mass spectrometry (ICP-MS) was employed to measure levels of nine essential metals in brain tissues, and compared concentrations between cases and controls, and between cohorts, to analyse effects of age, sex, Braak stage, brain weight, and PMD. The same methods were used to investigate the effects of PMD under more controlled conditions using ex vivo healthy adult rat-brain tissue. Metal concentrations in human brain were found to be unmodified by differences in age, sex-matching, Braak stage, brain weight, and PMD between cohorts. Some metals were, however, found to vary significantly across different regions in rat brains. These results indicate that investigations of metal homeostasis in AD and other neurodegenerative conditions can be reliably performed using brain tissues without confounding by varying PMD, age, sex-matching, brain weight, and Braak stage. However, regions of study should be selected carefully.
Hydrogen Recovery by Mixed Matrix Membranes Made from 6FCl-APAF HPA with Different Contents of a Porous Polymer Network and Their Thermal Rearrangement (2021)

Mixed matrix membranes (MMMs) consisting of a blend of a hydroxypolyamide (HPA) matrix and variable loads of a porous polymer network (PPN) were thermally treated to induce the transformation of HPA to polybenzoxazole (β-TR-PBO). Here, the HPA matrix was a hydroxypolyamide having two hexafluoropropyilidene moieties, 6FCl-APAF, while the PPN was prepared by reacting triptycene (TRP) and trifluoroacetophenone (TFAP) in a superacid solution. The most probable size of the PPN particles was 75 nm with quite large distributions. The resulting membranes were analyzed by SEM and AFM. Up to 30% PPN loads, both SEM and AFM images confirmed quite planar surfaces, at low scale, with limited roughness. Membranes with high hydrogen permeability and good selectivity for the gas pairs H<sub>2</sub>/CH<sub>4</sub> and H<sub>2</sub>/N<sub>2</sub> were obtained. For H<sub>2</sub>/CO<sub>2</sub>, selectivity almost vanished after thermal rearrangement. In all cases, their hydrogen permeability increased with increasing loads of PPN until around 30% PPN with ulterior fairly abrupt decreasing of permeability for all gases studied. Thermal rearrangement of the MMMs resulted in higher permeabilities but lower selectivities. For all the membranes and gas pairs studied, the balance of permeability vs. selectivity surpassed the 1991 Robeson's upper bound, and approached or even exceeded the 2008 line, for MMMs having 30% PPN loads. In all cases, the HPA-MMMs before thermal rearrangement provided good selectivity versus permeability compromise, similar to their thermally rearranged counterparts but in the zone of high selectivity. For H<sub>2</sub>/CH<sub>4</sub>, H<sub>2</sub>/N<sub>2</sub>, these nonthermally rearranged MMMs approach the 2008 Robeson's upper bound while H<sub>2</sub>/CO<sub>2</sub> gives selective transport favoring H<sub>2</sub> on the 1991 Robeson's bound. Thus, attending to the energy cost of thermal rearrangement, it could be avoided in some cases especially when high selectivity is the target rather than high permeability.
CDX-585, a Bispecific Antibody with Dual Targeting of ILT4 and PD-1 Checkpoint Pathways (2023)

Immunoglobulin-like transcript 4 (ILT4) is an immunosuppressive molecule predominantly expressed on myeloid cells. Recent studies combining ILT4 suppression with programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) blockade have shown promising signs of activity in immune checkpoint inhibitor refractory patients. We theorized that coupling ILT4 and PD-1/PD-L1 blockade in a bispecific antibody (bsAb) may provide greater immune activating properties than combining the individual mAbs due to enhanced bridging of APCs to T cells. To test this approach, we developed CDX-585, a tetravalent ILT4xPD-1 IgG1-scFv bsAb from novel PD-1 and ILT-4 mAbs. CDX-585 is a potent antagonist of both PD-1 and ILT4. CDX-585 promotes M1 macrophage polarization and enhances pro-inflammatory cytokine secretion in response to lipopolysaccharide or CD40 agonist mAb treatment. In mixed lymphocyte reaction (MLR) assays, CDX-585 is more potent than the combination of parental antibodies. In a humanized NCG mouse SK-MEL-5 tumor model, CDX-585 exhibits greater antitumor activity than the combination of parental mAbs. A pilot study of CDX-585 in cynomolgus macaques confirmed a mAb-like pharmacokinetic profile without noted toxicities. These studies demonstrate that CDX-585 effectively combines ILT4 and the PD-1 blockade into one molecule that is more potent than the combination of the parental antibodies, providing the rationale to advance this bsAb into clinical studies.
Semiconducting Polymer Nanospheres in Aqueous Dispersion Prepared by a Miniemulsion Process (2002)

A miniemulsion process has been used to create layers of conjugated semiconducting polymers from aqueous suspensions. Layers of particles with sizes ranging between 70 and 250 nm can be formed and annealing results in coalescing of the particles into large homogeneous domains (see Figure for a photoluminescence image of a Me-LPPP layer).