gebhart/patrepeval huggingface dataset:
Promoter Region of the Human Harvey ras Proto-Oncogene: Similarity to the EGF Receptor Proto-Oncogene Promoter (1985)

Regulation of transcription of members of the ras gene family undoubtably plays an important role in controlling cellular growth. Examination of this level of regulation requires identification of the promoter regions of the ras proto-oncogenes. Four major transcriptional start sites were detected in the human Harvey ras 1 proto-oncogene. The promoter region contains neither a TATA box nor a CAAT box in their characteristic upstream positions, has an extremely high G+C content (80 percent), and contains multiple GC boxes including seven CCGCCC repeats and three repeats of the inverted complement, GGGCGG. This region has strong promoter activity when placed upstream from the chloramphenicol acetyl transferase gene and transfected into monkey CV1 cells. In these ways the Harvey ras 1 proto-oncogene promoter resembles the promoter of the gene encoding the epidermal growth factor (EGF) receptor. The similarity between the two proto-oncogene promoters may be relevant to the mechanism by which the expression of such "growth control" genes is regulated.
GHz modulation bandwidth from single-longitudinal mode violet-blue VCSEL using nonpolar InGaN/GaN QWs (2016)

We achieved a -3dB modulation bandwidth of 1GHz with an ultra-low capacitance of &lt; 1pF in a 419nm vertical-cavity surface-emitting lasers (VCSEL). The VCSEL is based on nonpolar InGaN/GaN quantum-wells and a tunnel-junction intracavity contact.
The Optic Nerve Head inMyocilinGlaucoma (2006)

No major structural or morphologic difference of the ONH was detected in pooled data from subjects who had myocilin mutations compared with data from individuals with nonmyocilin glaucoma.
Synthesis of C8-Modified 2″-Deoxyadenosine with Carcinogenic Arylamines (2007)

The synthesis of phosphoramidites of C8-modified 2 ′-deoxyadenosine with carcinogenic arylamines p-anisidine and 4-aminobiphenyl is described. Two different methods were studied related to the glycon and base protection groups.
NON-ORAL POSTER 63: The Impact of Childbirth on Sexual Function: New Insight Through an Identical Twins Study (2005)

Botros, S M.; Abramov, Y; Miller, J J.; Sand, P K.; Nickolov, A; Gandhi, S; Goldberg, R P.Author Information
Short-wavelength intersubband absorption in strain compensated InGaAs/AlAs quantum well structures grown on InP (2003)

We have studied intersubband absorption in strain compensated InxGa1−xAs/AlAs/InyAl1−yAs multiple quantum wells and superlattices grown on InP. X-ray diffraction shows that the layers are pseudomorphically strained and exhibit slight compositional grading of the interfaces. Owing to the high AlAs barriers, the intersubband absorption can be tailored to wavelengths shorter than 2 μm. In some samples, a small, but non-negligible absorption is also observed with s-polarized light.
Geophysical fluid pressure prediction in the presence of multiple pressure mechanisms and complex geology with applications to deep wells (2008)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 2008Geophysical fluid pressure prediction in the presence of multiple pressure mechanisms and complex geology with applications to deep wellsAuthors: Alan R. HuffmanRichard W. LahannAlan R. HuffmanFusion Petroleum Technologies Inc. and Richard W. LahannFusion Petroleum Technologies Inc.https://doi.org/10.1190/1.3063899 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InReddit Permalink: https://doi.org/10.1190/1.3063899FiguresReferencesRelatedDetails SEG Technical Program Expanded Abstracts 2008 ISSN (print):1052-3812 ISSN (online):1949-4645 Copyright: 2008 Pages: 3713 publication data© 2008 Copyright © 2008 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 15 Dec 2008 CITATION INFORMATION Alan R. Huffman and Richard W. Lahann, (2008), "Geophysical fluid pressure prediction in the presence of multiple pressure mechanisms and complex geology with applications to deep wells," SEG Technical Program Expanded Abstracts : 2673-2673. https://doi.org/10.1190/1.3063899 Plain-Language Summary PDF DownloadLoading ...
Structure-function analysis of enterovirus protease 2A in complex with its essential host factor SETD3 (2022)

Enteroviruses cause a number of medically relevant and widespread human diseases with no approved antiviral therapies currently available. Host-directed therapies present an enticing option for this diverse genus of viruses. We have previously identified the actin histidine methyltransferase SETD3 as a critical host factor physically interacting with the viral protease 2A. Here, we report the 3.5 Å cryo-EM structure of SETD3 interacting with coxsackievirus B3 2A at two distinct interfaces, including the substrate-binding surface within the SET domain. Structure-function analysis revealed that mutations of key residues in the SET domain resulted in severely reduced binding to 2A and complete protection from enteroviral infection. Our findings provide insight into the molecular basis of the SETD3-2A interaction and a framework for the rational design of host-directed therapeutics against enteroviruses.
Compact Low-Profile Tunable Metasurface-Enabled Antenna With Near-Arbitrary Polarization (2016)

The design and characterization of a compact, low-profile metasurface-enabled antenna with tunable frequency and polarization characteristics is reported. This antenna is made possible by a tunable artificial magnetic conducting (AMC) substrate combined with tunable crossed end-loaded dipoles. Intertwined miniaturized periodic unit cells comprise the AMC, presenting a homogeneous interface to the dipoles above. Moreover, the AMC structure is predominantly air, making it very lightweight. Tunable capacitors on the dipoles allow the dynamic reconfiguration of their input impedances, which in turn allows for near-arbitrary dynamic adjusting of the antenna's polarization for the left- or right-hand circular as well as linear with various orientations. Measurements of a prototype showed comparable performance with commercially available alternatives that were more than three times as thick as the new design reported here.
Power Transfer Capability and Bifurcation Phenomena of Loosely Coupled Inductive Power Transfer Systems (2004)

Loosely coupled inductive power transfer (LCIPT) systems are designed to deliver power efficiently from a stationary primary source to one or more movable secondary loads over relatively large air gaps via magnetic coupling. In this paper, a general approach is presented to identify the power transfer capability and bifurcation phenomena (multiple operating modes) for such systems. This is achieved using a high order mathematical model consisting of both primary and secondary resonant circuits. The primary compensation is deliberately designed to make the primary zero phase angle frequency equal the secondary resonant frequency to achieve maximum power with minimum VA rating of the supply. A contactless electric vehicle battery charger was used to validate the theory by comparing the measured and calculated operational frequency and power transfer. For bifurcation-free operation, the power transfer capability and controllability are assured by following the proposed bifurcation criteria. Where controllable operation within the bifurcation region is achievable, a significant increase in power is possible.
Alterations of platelet function and clot formation kinetics after in vitro exposure to anti‐A and ‐B (2012)

Our findings demonstrate a wide range of effects that anti-A/B have on PLT function, clot formation, thrombin generation, PLT cytoskeletal function, and mediator release. These data provide potential explanations for clinical observations of increased red blood cell utilization in trauma and surgical patients receiving ABO-nonidentical blood products. Impaired hemostasis caused by anti-A/B interacting with A and B antigens on PLTs, soluble proteins, and perhaps even endothelial cells is a potential contributing factor to hemorrhage in patients receiving larger volumes of ABO-nonidentical transfusions.
Swollen Vesicles and Multiple Emulsions from Block Copolymers (2004)

We engineer novel structures by “stuffing” the aliphatic regions of self-assembled aggregates with hydrophobic homopolymer. These “stuffed” vesicles and multiple emulsions are formed in a one-step process when we rehydrate stuffed films made of amphiphilic block copolymer and hydrophobic homopolymer. Without such homopolymer, this system forms micelles. With homopolymer, vesicles form; varying vesicle membrane thicknesses show that these structures incorporate different amounts of homopolymer. Multiple emulsions, containing more homopolymer than stuffed vesicles, are also fabricated using this single-amphiphile system. The system's incorporation of homopolymer to modify the properties and morphology of the resultant structures is a convenient strategy for preparing self-assembled macromolecular structures with controllable properties.
ChemInform Abstract: New Route for the Synthesis of Benzimidazoles by a One‐Pot Multistep Process with Mono and Bifunctional Solid Catalysts. (2010)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Triflic Anhydride Mediated Synthesis of Imidazo[1,5-a]azines (2013)

Imidazo[1,5-a]azines are synthesized in moderate to excellent yields using a mild cyclodehydration/aromatization reaction triggered by the use of triflic anhydride (Tf2O) and 2-methoxypyridine (2-MeOPyr). Various substitution patterns and functional groups were found to be compatible under the optimized conditions. In addition, a 5-bromo-3-aryl derivative was also shown to be active in a Sonogashira cross-coupling and direct arylation reactions. A tertiary amide was compatible as a substrate leading to the synthesis of an imidazo[1,5-a]pyridinium triflate.
Enhancing Multi-Center Generalization of Machine Learning-Based Depression Diagnosis From Resting-State fMRI (2020)

Resting-state fMRI has the potential to help doctors detect abnormal behavior in brain activity and to diagnose patients with depression. However, resting-state fMRI has a bias depending on the scanner site, which makes it difficult to diagnose depression at a new site. In this paper, we propose methods to improve the performance of the diagnosis of major depressive disorder (MDD) at an independent site by reducing the site bias effects using regression. For this, we used a subgroup of healthy subjects of the independent site to regress out site bias. We further improved the classification performance of patients with depression by focusing on melancholic depressive disorder. Our proposed methods would be useful to apply depression classifiers to subjects at completely new sites.
Proceedings of the Canadian Association for HIV Research: Canadian Foundation for Infectious Diseases Professional Development Workshop for Viral Researchers (2019)

In March 2018, the Canadian Association for HIV Research (CAHR) and Canadian Foundation for Infectious Diseases (CFID) collaborated to conduct a workshop targeted to mid-career virology researchers. Key objectives of the workshop included 1) sharing knowledge and expertise cutting across various viral diseases, 2) developing collaborations as we anticipate the next wave of suppressive and curative treatment for HIV, HBV, CMV, and other viral diseases, and 3) providing insights, advice, and "food for thought" as participants advance to mid- and later phases of their research careers. This article reports on the key topics contemplated including scientific misinformation within the public realm, network building, interdisciplinary collaboration, mentorship, and communicating with decision makers. Given the focus on virology, the Canadian Society for Virology was invited to highlight their efforts to build a cohesive network that is impactful in facilitating viral research in Canada including advocating for appropriate levels of peer-reviewed research funding. Many key pearls of wisdom are contained within this document which are of value to all researchers aiming for success in a continually evolving, complex, and challenging Canadian research and academic environment.
Method for quantitative analysis of nonsense-mediated mRNA decay at the single cell level (2015)

Nonsense-mediated mRNA decay (NMD) is a ubiquitous mechanism of degradation of transcripts with a premature termination codon. NMD eliminates aberrant mRNA species derived from sources of genetic variation such as gene mutations, alternative splicing and DNA rearrangements in immune cells. In addition, recent data suggest that NMD is an important mechanism of global gene expression regulation. Here, we describe new reporters to quantify NMD activity at the single cell level using fluorescent proteins of two colors: green TagGFP2 and far-red Katushka. TagGFP2 was encoded by mRNA targeted to either the splicing-dependent or the long 3'UTR-dependent NMD pathway. Katushka was used as an expression level control. Comparison of the fluorescence intensities of cells expressing these reporters and cells expressing TagGFP2 and Katushka from corresponding control NMD-independent vectors allowed for the assessment of NMD activity at the single cell level using fluorescence microscopy and flow cytometry. The proposed reporter system was successfully tested in several mammalian cell lines and in transgenic Xenopus embryos.
Massive MIMO processing at the semiconductor edge: Exploiting the system and circuit margins for power savings (2017)

Massive MIMO has the potential to bring great spectral and energy efficiency improvements, making it a very promising technology for future wireless systems. Essential to achieve the gains in practice, is the ability to realize the many antenna paths at low complexity. In this paper, we consider the potential of processing at the semiconductor edge by allowing voltage over-scaling and complete antenna signal failures, focusing on the per-antenna digital functionality that dominant the DSP complexity. The impact of the resulting hardware errors on the performance of Massive MIMO transmission is analyzed. It shows that the inherent redundancy in the system brings a solid tolerance to sporadic hardware errors. Potential control tactics are introduced, that could further optimize the operation of the error-prone circuitry. We anticipate that by exploiting the system and circuit margins, up to 40% power reduction could be achieved on the considered DSP functions without sacrificing performance in many traffic scenarios.
Association between Loneliness and Diseases Self-Management in Older Adults: Systematic Review (2021)

Abstract Purpose: Older adults with chronic diseases are more at risk for loneliness, and loneliness has a negative impact on health behaviors, which are key to managing chronic diseases. However, little is known about the association between loneliness and self-management behaviors in older adults with chronic diseases. As societies worldwide experience the growth of aging populations who are at higher risk of having chronic diseases as they age, clinicians and researchers should assess and address loneliness of older adults with chronic diseases. Methods: This systematic review synthesizes research found in PubMed, MEDLINE, PsychINFO, CINAHL, and SocINDEX. Findings: fourteen studies were conducted in four countries and represented n= 128,610. Loneliness was measured by three different instruments. Reports of loneliness were frequent and ranged from 7.7% (in a report of severe loneliness) to 43.2% (moderate loneliness) of older adults. Older adults who experienced loneliness were less likely to be physically active, eat a healthy diet, or cope in positive ways and more likely to be female and seek healthcare. Conclusions: This systematic review found that loneliness was moderately prevalent, and that loneliness was associated with negative disease self-management behaviors in older adults with chronic diseases. Gaps in the research include a need for studies guided by theoretical pathways, using a consistent, theoretically-based measure of loneliness, and conducted on among people with specific chronic diseases.
Inverse Filtering Design Using a Minimal-Phase Target Function from Regularization (2006)

Inverse filtering methods commonly use amplitude regularization as a technique to limit the amount of work done by the inverse filter. The amount of regularization needed must be carefully selected so that the audio quality is not degraded. This paper introduces a method of using the magnitude of the regularization to design a target/desired response in which the phase response can be arbitrarily chosen. By choosing a minimum-phase response, one can reduce any pre-response in the corrected signal that is introduced by the regularization. A phase response that consists of a frequency-dependent mixture of minimumand zero-phase components is also introduced. Informal listening tests were performed to verify the effectiveness of the new method.
Pertussis toxin interferes with superantigen-induced deletion of peripheral T cells without affecting T cell activation in vivo. Inhibition of deletion and associated programmed cell death depends on ADP-ribosyltransferase activity. (1994)

Intravenous injection of a bacterial superantigen such as Staphylococcus aureus enterotoxin B (SEB) causes transient activation and expansion of SEB-reactive V beta 8+ T cells, as well as specific down-regulation of the immune response, through partial deletion of superantigen-reactive T cells. Here we demonstrate that co-administration of pertussis toxin (PTX) and SEB reduces the SEB-induced deletion of V beta 8+ T cells, although it does not affect T cell activation and proliferation. PTX abrogates the SEB-driven deletion of V beta 8+CD4+ (not V beta 8+CD8+) splenocytes that is observed early (12-24 h) after SEB injection. Moreover, it antagonizes the late (> or = 4 days) deletion of V beta 8+CD4+ and V beta 8+CD8+ peripheral T cells that follows transient expansion of such cells. This phenomenon is associated with significant reductions in apoptosis and endonucleolysis and is not caused by a compensatory increase in proliferation of SEB-reactive T cells, as we determined by using a combined fluorometric analysis of cell cycle and DNA alterations, which are associated with programmed cell death. These effects are also observed in thymectomized animals, thus excluding the possibility that PTX might act by enhancing the maturation and export of thymic T cells to the periphery. Moreover, the SEB-induced reduction of V beta 8+ splenocytes is antagonized by PTX in vitro. The capacity of PTX to reduce clonal deletion depends critically on its ADP-ribosyltransferase activity, inasmuch as a non-enzymatic PTX mutant fails to act in this biologic system. We conclude that PTX selectively antagonizes or impedes the delivery of negative signals to T cells, which are stimulated by superantigens, without interfering with the transmission of stimulatory signals.
Micro-cantilever Array Pressure Measurement System for Biomedical Instrumentation (2007)

An analog signal processing IC for micro-cantilever array is designed for pressure measurement in biomedical applications. The chip includes analog multiplexer, instrumentation amplifier, sample and hold circuit, on chip voltage reference, SAR ADC and digital control unit. The 8-b ADC attains 45.4 dB SNDR and 56.4 dB SFDR while operating at 772 KHz. The chip occupies an area of 1.54 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and consumes 17.8 mW power with a single 3.3 V supply. The chip was fabricated in a 0.35 mum 2-poly 4-metal process.
Inarijärven kalatalouden kehittämisen monitavoitearviointi (2015)

ei tietoa saavutettavuudesta
Clinical Usefulness of Endometrial Cytology in Determining the Therapeutic Effect of Fertility Preserving Therapy (2021)

The sensitivity of endometrial cytology in determining the therapeutic effect of MPA therapy is low, and we confirmed that the omission of D&amp;C is unacceptable. Our findings also suggested that the addition of cytological evaluation to D&amp;C during MPA therapy had a low clinical significance.
Supramolecular electron transfer by anion binding (2012)

Anion binding has emerged as an attractive strategy to construct supramolecular electron donor-acceptor complexes. In recent years, the level of sophistication in the design of these systems has advanced to the point where it is possible to create ensembles that mimic key aspects of the photoinduced electron-transfer events operative in the photosynthetic reaction centre. Although anion binding is a reversible process, kinetic studies on anion binding and dissociation processes, as well as photoinduced electron-transfer and back electron-transfer reactions in supramolecular electron donor-acceptor complexes formed by anion binding, have revealed that photoinduced electron transfer and back electron transfer occur at time scales much faster than those associated with anion binding and dissociation. This difference in rates ensures that the linkage between electron donor and acceptor moieties is maintained over the course of most forward and back electron-transfer processes. A particular example of this principle is illustrated by electron-transfer ensembles based on tetrathiafulvalene calix[4]pyrroles (TTF-C4Ps). In these ensembles, the TTF-C4Ps act as donors, transferring electrons to various electron acceptors after anion binding. Competition with non-redox active substrates is also observed. Anion binding to the pyrrole amine groups of an oxoporphyrinogen unit within various supramolecular complexes formed with fullerenes also results in acceleration of the photoinduced electron-transfer process but deceleration of the back electron transfer; again, this is ascribed to favourable structural and electronic changes. Anion binding also plays a role in stabilizing supramolecular complexes between sulphonated tetraphenylporphyrin anions ([MTPPS](4-): M = H(2) and Zn) and a lithium ion encapsulated C(60) (Li(+)@C(60)); the resulting ensemble produces long-lived charge-separated states upon photoexcitation of the porphyrins.
A Trial of Intrapleural Adenoviral-mediated Interferon-α2b Gene Transfer for Malignant Pleural Mesothelioma (2011)

New therapeutic strategies are needed for malignant pleural mesothelioma (MPM). We conducted a single-center, open-label, nonrandomized, pilot and feasibility trial using two intrapleural doses of an adenoviral vector encoding human IFN-α (Ad.IFN-α2b). Nine subjects were enrolled at two dose levels. The first three subjects had very high pleural and systemic IFN-α concentrations resulting in severe "flu-like" symptoms necessitating dose de-escalation. The next six patients had reduced (but still significant) pleural and serum IFN-α levels, but with tolerable symptoms. Repeated vector administration appeared to prolong IFN-α expression levels. Anti-tumor humoral immune responses against mesothelioma cell lines were seen in seven of the eight subjects evaluated. No clinical responses were seen in the four subjects with advanced disease. However, evidence of disease stability or tumor regression was seen in the remaining five patients, including one dramatic example of partial tumor regression at sites not in contiguity with vector infusion. These data show that Ad.IFN-α2b has potential therapeutic benefit in MPM and that it generates anti-tumor immune responses that may induce anatomic and/or metabolic reductions in distant tumor. Clinical trial registered with www.clinicaltrials.gov (NCT 01212367).