gebhart/patrepeval huggingface dataset:
Identification and Characterization of a Receptor from Goldfish Specific for a Teleost Growth Hormone-Releasing Hormone-Like Peptide (1998)

In mammals, growth hormone-releasing hormone (GHRH), acting via the GHRH receptor, plays an important role in the regulation of growth hormone (GH) synthesis and secretion as well as the proliferation and differentiation of somatotropes in the pituitary. In fishes, information concerning the functional role of the characterized GHRHs is limited. For that reason, a putative goldfish GHRH receptor cDNA was characterized in this study. The receptor cDNA is 2,243 bp in length, encoding a 438-amino-acid-long polypeptide with 7 putative transmembrane-spanning regions, which is a characteristic of G-protein-coupled receptors. The receptor, when expressed in COS-7 cells, showed minimal responses (2-fold cAMP responses) when stimulated with 100 nM of human GHRH, pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal polypeptide (VIP). However, this receptor was found to be specific for a carp GHRH-like peptide isolated from the brain of common carp (Cyprinus carpio); there was a significant and dose-dependent increase in intracellular cAMP (a maximum response of 22-fold increase with an EC50 of 0.1 nM) when the transfected cells were stimulated with this peptide. As a preliminary study to investigate the functional role of this receptor, the tissue distribution of the mRNA was analyzed by reverse-transcription-polymerase chain reaction. The receptor mRNA was found to be present in the brain, pituitary, gut, gill, heart, liver, skeletal muscle, spleen, ovary and testis. Together with a goldfish PACAP type 1 receptor and a VIP1 receptor recently isolated in our laboratory, characterization of this putative GHRH receptor provides the molecular basis for the future understanding of the neuroendocrine control of growth and reproduction by these neuropeptides in goldfish as well as other teleosts.
Degeneration Behavior of Cu Nanowires under Carbon Dioxide Environment: An In Situ/Operando Study (2021)

Copper (Cu) is a catalyst broadly used in industry for hydrogenation of carbon dioxide, which has broad implications for environmental sustainability. An accurate understanding of the degeneration behavior of Cu catalysts under <i>operando</i> conditions is critical for uncovering the failure mechanism of catalysts and designing novel ones with optimized performance. Despite the widespread use of these materials, their failure mechanisms are not well understood because conventional characterization techniques lack the necessary time and spatial resolution to capture these complex behaviors. In order to overcome these challenges, we carried out transmission electron microscopy (TEM) with a specialized <i>in situ</i> gas environmental holder, which allows us to unravel the dynamic behavior of the Cu nanowires (NWs) <i>in operando</i>. The failure process of these nanoscale Cu catalysts under CO<sub>2</sub> atmosphere were tracked and further rationalized based on our numerical modeling using phase-field methods.
Adaptive resource allocation and frame scheduling for wireless multi-user video streaming (2005)

We propose an application-driven multi-user resource allocation and frame scheduling concept for wireless video streaming. Our approach is based on joint optimization of the application layer, the data link layer and the physical layer. For this, key parameters from these three layers are abstracted. The abstracted parameters at the application layer describe the rate-distortion characteristics of the pre-encoded video streams. At the lower layers they describe the current transmission characteristics of all users. The outcome of the joint optimization leads to adaptive resource allocation at the lower layers and an adaptive decision on which frames to send on the application layer. We show that for our scenario the expected video quality at the client side can be described analytically which leads to low complexity joint optimization. The performance of our approach is demonstrated using a real-time testbed implementation.
Supplementary Movie 2 from Selectin Ligand Sialyl-Lewis x Antigen Drives Metastasis of Hormone-Dependent Breast Cancers (2023)

&lt;p&gt;MOV file - 7.3MB&lt;/p&gt;
Distributed Base Station: A Concept System for Long-Range Broadband Wireless Access (2021)

We propose a concept system termed distributed base station (DBS) which enables distributed transmit beamforming at large carrier wavelengths to achieve significant range extension and/or increased downlink data rate, providing a low-cost infrastructure for applications such as rural broadband. We consider a frequency division duplexed (FDD) system using feedback from the receiver to achieve the required phase coherence. At a given range, N cooperating transmitters can achieve N2-fold increase in received power compared to that for a single transmitters, and feedback-based algorithms with near-ideal performance have been prototyped. In this paper, however, we identify and address key technical issues in translating such power gains into range extension via a DBS. First, to combat the drop in per-node SNR with extended range, we design a feedback-based adaptation strategy that is suitably robust to noise. Second, to utilize available system bandwidth, we extend narrowband adaptation algorithms to wideband channels through interpolation over OFDM subcarriers. Third, we observe that the feedback channel may become a bottleneck unless sophisticated distributed reception strategies are employed, but show that acceptable performance can still be obtained with standard uplink reception if channel time variations are slow enough. We quantify system performance compactly via outage capacity analyses.
<title>Write/read performance in two-photon 3D memories</title> (1993)

We describe progress in developing a 3D optical memory using 2 photon optical recording. The memory can be designed for bit, line, or page oriented data storage. We discuss advantages and drawbacks to each addressing method in terms of the capacity, storage density, and peripheral devices. We conclude with the most recent experimental results for multiple image storage using 2-photon recording.
Binding of Insulin to Thymocytes from Suckling and Hypophysectomized Rats: Evidence for Two Mechanisms Regulating Insulin Sensitivity (1975)

Insulin more effectively increased amino acid influx into thymocytes isolated from insulin-sensitive suckling and hypophysectomized rats than into cells obtained from normal adult animals. Thymocytes from hypophysectomized adult rats bound more insulin than did cells from sham-operated controls, suggesting that insulin sensitivity in this condition was due to an increase in the number of insulin receptors. In contrast, thymocytes from suckling rats bound the same amount of insulin as did cells from adult animals, suggesting that in this instance insulin sensitivity was the result of changes in events subsequent to the binding of insulin.
Application du retournement temporel au contrôle non destructif (1994)

L'utilisation d'un miroir ultrasonore à retournement temporel est une méthode originale pour détecter de petits défauts situés dans des solides hétérogènes de forme complexe. Le Retournement Temporel (RT) est une technique auto-adaptative qui réalise en temps réel une procédure de focalisation adaptée à la fois aux géométries de la sonde et de l'interface solide-liquide, aux caractéristiques du milieu de propagation et à la forme du défaut. Dans les milieux solides très diffusants le niveau du bruit de speckle est élevé et il gêne la détection des défauts. Le RT permet d'améliorer cette détection, d'une part en focalisant de façon optimale sur les défauts et d'autre part en réduisant le niveau du bruit. En effet, cette technique se comporte différemment selon que les signaux proviennent d'un défaut ou du bruit de speckle. De plus, en itérant le processus de RT, il est possible de différencier lors d'un contrôle les zones contenant un défaut des zones ne contenant que du bruit de speckle.
Supplementary File 14 from Genome-Wide Functional Synergy between Amplified and Mutated Genes in Human Breast Cancer (2023)

Supplementary File 14 from Genome-Wide Functional Synergy between Amplified and Mutated Genes in Human Breast Cancer
Combined M.D./Ph.D. and Ph.D. Training Program in Breast Cancer Prevention (2001)

Abstract : The goal of this training program is to dramatically extend our existing, highly successful Interdisciplinary Doctoral Training Program in Tumor Biology with a track which integrates genetics, molecular epidemiology, and prevention of breast cancer. This track offers both MD/PhD and PhD training opportunities, and integrates new faculty from the Lombardi Cancer Center Program in Cancer Prevention and Control, and Cancer Genetics. The program is enriched by new courses, as well as practical research experience. This new programmatic initiative makes use of the existing organizational structure of the Interdisciplinary Doctoral Training Program in Tumor Biology and incorporates a multi- disciplinary faculty who are devoted to research and education in breast cancer. We recruited 3 MDs to the program in the third year. All three MDs have had a successful first year and are continuing into their second year of enrollment in the program. Two courses, Genetics Health and Society in the 2lst Century and Applied Biostatistics had a successful first year and will continue to be offered. Finally, a new course in genetics, Human and Microbial Genetics, will be offered in the fall semester.
Performance of Downlink Frequency Domain Packet Scheduling for the UTRAN Long Term Evolution (2006)

In this paper we investigate the potential of downlink frequency domain packet scheduling (FDPS) for the 3GPP UTRAN long-term evolution. Utilizing frequency-domain channel quality reports, the scheduler flexibly multiplexes users on different portions of the system bandwidth. Compared to frequency-blind, but time-opportunistic scheduling, FDPS shows gains in both average system capacity and cell-edge data rates on the order of 40%. However, the FDPS performance is shown to depend significantly on the frequency-domain scheduling resolution as well as the accuracy of the channel state reports. Assuming typical urban channel profile, studies show that the scheduling resolution should preferably be as low as 375 kHz to yield significant FDPS gain with two-branch receive diversity and in 20 MHz. Further, to have convincing FDPS gain the std. of error of radio state reports needs to be kept within 1.5-2 dB
The Remains of Anterior Cruciate Ligament Graft Tension after Cyclic Knee Motion (2005)

These results provide one possible explanation for early slackening of anterior cruciate ligament reconstructions.
Leveraging Gans to Improve Continuous Path Keyboard Input Models (2020)

Continuous path keyboard input has higher inherent ambiguity than standard tapping, because the path trace may exhibit not only local overshoots/undershoots (as in tapping) but also, depending on the user, substantial mid-path excursions. Deploying a robust solution thus requires a large amount of high-quality training data, which is difficult to collect/annotate. In this work, we address this challenge by using GANs to augment our training corpus with user-realistic synthetic data. Experiments show that, even though GAN-generated data does not capture all the characteristics of real user data, it still provides a substantial boost in accuracy at a 5:1 GAN-to-real ratio. GANs therefore inject more robustness in the model through greatly increased word coverage and path diversity.
ChemInform Abstract: Exploiting the Use of Ionic Liquids to Access Phosphorodiamidites. (2012)

Abstract Highly moisture‐sensitive phosphorodiamidites (III) and (V) are selectively formed by reaction of alkoxydichlorophosphine with secondary amines in ionic liquids as reaction medium.
Rapid insulin-stimulated accumulation of an mRNA encoding a proline-rich protein. (1990)

By differential hybridization screening of a cDNA library derived from insulin-stimulated cells, we selected a clone which hybridized to an mRNA species that rapidly accumulated in response to insulin. The insert from this clone encoded a putative polypeptide of Mr 33,600, pI 11.2; because the protein was enriched in proline residues (14.4 mol %) and contained three Pro-Pro-Pro-Pro repeats, we have tentatively labeled it tris-tetraprolin (TTP). The function of this protein is not known, but it contains two regions very rich in proline (30-40 mol %); similar proline-rich regions have been shown to be involved in transcriptional activation by other proteins. The mRNA (2.0 kilobases) encoding the TTP protein was essentially undetectable in serum-deprived HIR 3.5 cells, but accumulated dramatically within 10 min of stimulation by insulin. This effect appeared to be due to insulin acting through the intrinsic protein-tyrosine kinase activity of its own receptor. Insulin induction of TTP mRNA accumulation was prevented by actinomycin D and superinduced by cycloheximide. Accumulation of TTP mRNA was also stimulated by a variety of growth factors and active phorbol esters; however, the insulin effect was virtually normal in cells depleted of protein kinase C. A single TTP gene appeared to be present in the mouse genome. This gene joins the group of genes whose members are rapidly transcribed in response to insulin and other mitogens.
Synthesis and Structural Revision of the Fungal Tetramic Acid Metabolite Spiroscytalin (2017)

Spiroscytalin, a natural 3-spirotetramic acid of hitherto uncertain absolute configuration, was synthesized for the first time by a one-pot Knoevenagel-IMDA reaction of an l-phenylalanine-derived tetramic acid and (R)-2-methyl-deca-6E,8E-dienal. Its absolute configuration was assigned by the known configurations of the starting compounds and by NOESY correlations. Its identity with the natural isolate was proved by the comparison of the NMR and circular dichroism spectra and of the specific optical rotations. Its absolute configuration (3R,5S,6S,7R,11S,14R) is enantiomeric to that originally proposed by the isolating group. This natural isomer of spiroscytalin showed moderate activity against Candida albicans and good activity against an export-deficient mutant of Escherichia coli.
DeepURL: Deep Pose Estimation Framework for Underwater Relative Localization (2020)

In this paper, we propose a real-time deep learning approach for determining the 6D relative pose of Autonomous Underwater Vehicles (AUV) from a single image. A team of autonomous robots localizing themselves in a communication-constrained underwater environment is essential for many applications such as underwater exploration, mapping, multi-robot convoying, and other multi-robot tasks. Due to the profound difficulty of collecting ground truth images with accurate 6D poses underwater, this work utilizes rendered images from the Unreal Game Engine simulation for training. An image-to-image translation network is employed to bridge the gap between the rendered and the real images producing synthetic images for training. The proposed method predicts the 6D pose of an AUV from a single image as 2D image keypoints representing 8 corners of the 3D model of the AUV, and then the 6D pose in the camera coordinates is determined using RANSAC-based PnP. Experimental results in real-world underwater environments (swimming pool and ocean) with different cameras demonstrate the robustness and accuracy of the proposed technique in terms of translation error and orientation error over the state-of-the-art methods. The code is publicly available.
ChemInform Abstract: TRIBOLUMINESCENCE OF INORGANIC SULFATES (1980)

Abstract Spektroskopische und mechanische Untersuchungen an 45 anorganischen Sulfaten ergeben, daß alle nicht punktsymm.
Regulation of Endothelial Cell Adhesion Molecule Expression in an Experimental Model of Cerebral Malaria (2002)

Objective: Plasmodium falciparum malaria in humans and animal models of this disease have revealed changes in the infected host that are consistent with a systemic inflammatory response. Although it has been proposed that endothelial cell adhesion molecules (CAM) contribute to the adhesive interactions of Plasmodium-infected erythrocytes and immune cells with vascular endothelial cells, ECAM expression has not been systematically studied in Plasmodium-infected animals. Methods: In this study, the dual radiolabeled monoclonal antibody method was used to quantify the expression of different ECAMs (ICAM-1, VCAM-1, P-selectin, E-selectin) in different regional vascular beds of Plasmodium berghei ANKA-inffected mice (PbA), a well-recognized model of human cerebral malaria. The roles of T lymphocytes and certain cytokines (TNF-α, IL-12, IFN-γ) in mediating the infection-induced expression of ICAM-1 and P-selectin were assessed by using relevant mutant mice. Results: Wild-type (WT) mice exhibited highly significant increases in the expression of ICAM-1, VCAM-1, and P-selectin (but not E-selectin) in all vascular beds on the 6th day of PbA infection. The PbA-induced upregulation of ICAM-1 was significantly blunted in mice that were either deficient in IFN-α, IL-12 (but not TNF1b) or T lymphocytes (Rag-1 deficiency); however, these responses were tissue specific. Conclusions: These findings indicate that vascular endothelial cells in most regional circulations assume an inflammatory phenotype and that cytokines and immune cells mediate this response in a tissue-specific manner.
A Multi-Institution Phase I Trial of Ruxolitinib in Patients with Chronic Myelomonocytic Leukemia (CMML) (2016)

The recommended phase II dose of ruxolitinib is 20 mg twice daily. We demonstrate that ruxolitinib has promising activity in CMML with particular benefit in those with disease-related B symptoms that warrants further study. Clin Cancer Res; 22(15); 3746-54. ©2016 AACRSee related commentary by Solary, p. 3707.
Pulsating solitons, chaotic solitons, period doubling, and pulse coexistence in mode-locked lasers: Complex Ginzburg-Landau equation approach (2001)

The complex Ginzburg-Landau equation (CGLE) is a standard model for pulse generation in mode-locked lasers with fast saturable absorbers. We have found complicated pulsating behavior of solitons of the CGLE and regions of their existence in the five-dimensional parameter space. We have found zero-velocity, moving and exploding pulsating localized structures, period doubling (PD) of pulsations and the sequence of PD bifurcations. We have also found chaotic pulsating solitons. We have plotted regions of parameters of the CGLE where pulsating solutions exist. We also demonstrate the coexistence (bi- and multistability) of different types of pulsating solutions in certain regions of the parameter space of the CGLE.
Preparation and physicochemical properties of natural (23R)-3α,7α,23- and (23R)-3α,12α,23-trihydroxylated bile acids and their (23S)-epimers (1989)

By submitting the ketene silyl acetyl (5a) generated from 3α,7α-dihydroxy-5β-cholan-24-oic acid [chenodeoxycholic acid (1a)], to a variety of oxidants, a new efficient route to (23R)-3α,7α,23-trihydroxy-5β-cholan-24-oic acid [phocaecholic acid, (3a)] and its (23S)-epimer (4a) has been developed. By this route, the first synthesis of 3α,12α,23-trihydroxy-5β-cholan-24-oic acid (bitocholic acid) has been achieved and the stereochemistry at C-23 conclusively assigned as R. Aqueous physical chemical properties of (3a) have been studied and compared with those of (1a) and 3α,7α,12α-trihydroxy-5β-cholan-24-oic acid [cholic acid, (1b)], in order to gain insight into the influence of the hydroxy group at C-23 on the physical properties of bile acids.
AdRoit: an accurate and robust method to infer complex transcriptome composition (2020)

Abstract Bulk RNA sequencing technology provides the opportunity to understand biology at the whole transcriptome level without the prohibitive cost of single cell profiling. Advances in spatial transcriptomics enable to dissect tissue organization and function by genome-wide gene expressions. However, the readout of both technologies is the overall gene expression across potentially many cell types without directly providing the information of cell type constitution. Although several in-silico approaches have been proposed to deconvolute RNA-Seq data composed of multiple cell types, many suffer a deterioration of performance in complex tissues. Here we present AdRoit, an a ccurate an d ro bust method infer the cell composition from t ranscriptome data comprised of multiple cell types. AdRoit uses gene expression profile obtained from single cell RNA sequencing as a reference. It employs an adaptive learning approach to correct the sequencing technique difference between the single cell data and the bulk or spatial transcriptome data, enabling cross-platform readout comparability. Our systematic benchmarking and applications, which include deconvoluting complex mixtures that encompass 30 cell types, demonstrate its superior sensitivity and specificity compared to other existing methods as well as its utilities. In addition, AdRoit is computationally efficient and runs orders of magnitude faster than many existing methods.
High-level secretion of tissue factor-rich extracellular vesicles from ovarian cancer cells mediated by filamin-A and protease-activated receptors (2015)

Thromboembolic events occur frequently in ovarian cancer patients. Tissue factor (TF) is often overexpressed in tumours, including ovarian clear-cell carcinoma (CCC), a subtype with a generally poor prognosis. TF-coagulation factor VII (fVII) complexes on the cell surface activate downstream coagulation mechanisms. Moreover, cancer cells secrete extracellular vesicles (EVs), which act as vehicles for TF. We therefore examined the characteristics of EVs produced by ovarian cancer cells of various histological subtypes. CCC cells secreted high levels of TF within EVs, while the high-TF expressing breast cancer cell line MDA-MB-231 shed fewer TF-positive EVs. We also found that CCC tumours with hypoxic tissue areas synthesised TF and fVII in vivo, rendering the blood of xenograft mice bearing these tumours hypercoagulable compared with mice bearing MDA-MB-231 tumours. Incorporation of TF into EVs and secretion of EVs from CCC cells exposed to hypoxia were both dependent on the actin-binding protein, filamin-A (filA). Furthermore, production of these EVs was dependent on different protease-activated receptors (PARs) on the cell surface. These results show that CCC cells could produce large numbers of TF-positive EVs dependent upon filA and PARs. This phenomenon may be the mechanism underlying the increased incidence of venous thromboembolism in ovarian cancer patients.