gebhart/patrepeval huggingface dataset:
Atomistic Pseudo-Transient BTI Simulation With Inherent Workload Memory (2014)

Bias Temperature Instability (BTI) is a major concern for the reliability of decameter to nanometer devices. Older modeling approaches fail to capture time-dependent device variability or maintain a crude view of the device's stress. Previously, a two-state atomistic model has been introduced, which is based on gate stack defect kinetics. Its complexity has been preventing seamless integration in simulations of large device inventories over typical system lifetimes. In this paper, we present an approach that alleviates this complexity. We introduce a novel signal representation for the gate stress. Using this format, atomistic BTI simulations require less model iterations while exhibiting minimum accuracy degradation. We also enable full temperature and voltage supply dependency since these attributes are far from constant in modern integrated systems. The proposed simulation methodology retains both the atomistic property and the workload memory that remain major differentiators of defect-based BTI simulation, in comparison to state-of-the-art approaches.
Simultaneous quantification of lignans in Arabidopsis thaliana by highly sensitive capillary liquid chromatography-electrospray ionization-ion trap mass spectrometry (2011)

Lignans are phenylpropanoid dimers in which the monomers are linked by the central carbon (C8) atoms. Because many lignans have physiological effects, including antioxidant activity, they are now in demand as components in health foods. However, the lignan biosynthetic pathways in plants are only now being understood. Recently, lariciresinol was detected in Arabidopsis thaliana. This observation indicated the existence of common lignan biosynthetic pathways in A. thaliana, despite a low amount of lignans other than lariciresinol glycosides. In this study, we established a highly sensitive analytical method that enables quantification of both glycoside and aglycone forms of lignans in A. thaliana simultaneously using capillary liquid chromatography-electrospray ionization-ion trap mass spectrometry. Some lignans not previously detected in A. thaliana were quantified in extracts of both roots and shoots. Our method can be used for the comprehensive analysis of lignans in small samples from mutants and transformants. This method will be utilized to elucidate the metabolic pathways and physiological roles of lignans as well as the regulation of their biosynthesis in plants.
(Invited) Recent Development on Fullerene-Based Nano-PDT Drugs for Photo-Inactivation of Infectious Bacteria and Cancer Cells (2013)

Abstract not Available.
FY2011 Engineering Innovations, Research, and Technology Report (2012)

This report summarizes key research, development, and technology advancements in Lawrence Livermore National Laboratory’s Engineering Directorate for FY2011. These efforts exemplify Engineering’s nearly 60-year history of developing and applying the technology innovations needed for the Laboratory’s national security missions, and embody Engineering’s mission to “Enable program success today and ensure the Laboratory’s vitality tomorrow.
Trench Film Cooling: Effect of Trench Downstream Edge and Hole Spacing (2008)

The present study is a continuation of an experimental investigation of film cooling from cylindrical holes embedded in transverse trenches. In this study, focus is on varying the downstream edge of the trench by angling it along the flow. Different edge angles are studied for the same trench depth. Also, the effect of hole spacing is considered for one of the standard trenches from previous studies to understand the effect of trenching on overall coolant usage. Detailed heat transfer coefficient and film effectiveness measurements are obtained simultaneously using a single test transient IR thermography technique. The study is performed at a single mainstream Reynolds number based on free-stream velocity and film hole diameter of 11000 at four different coolant-to-mainstream blowing ratios of 0.5, 1.0, 1.5 and 2.0. The results show that film effectiveness is greatly enhanced by the trenching due to improved two dimensional nature of the film and lateral spreading. The detailed heat transfer coefficient and film effectiveness contours provide a clear understanding of the jet-mainstream interactions for different hole orientations. The effect of edge angling is minimal on the overall cooling effectiveness but may have an impact on jet-mainstream interaction aerodynamic losses.
Intraperitoneal Pressure in Polycystic and Non-Polycystic Kidney Disease Patients, Treated by Peritoneal Dialysis (2020)

Patients with larger BMI have greater IPP, irrespectively to IPV. In PKD patients, hTKV correlate with IPP/IPV ratio. However, given the wide range of distribution of hTKV, increased IPP cannot be presumed because of pre-existing polycystic kidney, but need to be quantified.
Photonic crystal structures with large densities of states (2004)

Our work on photonic crystal structures exhibiting large densities of optical states, including high-quality nanocavities and two-dimensional coupled nanocavity arrays, is presented. Applications ranging from nanoscale and nonlinear optics to quantum information processing are discussed.
Who is the Inventor? (2012)

This chapter contains sections titled: Conceiving an Inventive Idea Joint Inventors Naming Inventors on Patent Applications Qualifications to Be an Inventor
Methods for patterned deposition on a substrate (2023)

A method is described for patterned depositions of a material onto a substrate. A surface of a polymeric substrate is first etched so as to form an etched layer having enhanced adhesions characteristics and then selected portions of the etched layer are removed so as to define a pattern having enhanced and diminished adhesion characteristics for the deposition of a conductor onto the remaining etched layer. In one embodiment, a surface of a PTFE substrate is chemically etched so as to improve the adhesion of copper thereto. Thereafter, selected portions of the etched surface are irradiated with a laser beam so as to remove the etched selected portions of the etched surface and form patterns of enhanced and diminished adhesion of copper thereto.
Directional strain measurement using fiber-optic polarimetric sensor (2007)

Method for viscosity measurement has not changed significantly over the past several decades. Most common techniques either require sample to be taken from the material to be measured or special installation of a side stream to be set up to monitor the viscosity. Here we present a compact fiber optic based viscometer based on damping measurement stem from interaction between fluid and the optical sensor. The fluid viscosity measurement is deduced from the fluid's frictional damping on the surface of the immersed vibrating fiber optic probe. This frictional damping, which becomes the dominant factor in the fluid damping under a small fiber's vibration, is a function of viscosity. Utilizing an intrinsic polarimetric technique, the fiber's vibration profile can be measured and thus damping characteristic due to viscosity on the probe can be derived. The uniqueness of the sensor is its compact size and potential application in an industrial environment without any additional modification to the existing sensor or the industrial setting. The sensor is also potentially can be made portable so that operators can take with them to the test site. Here theoretical and preliminary results will be presented.
Sector-based resource allocation for broadband fixed wireless networks (2002)

We present a sector-based resource allocation scheme for broadband fixed wireless networks. For SIR requirements of about 12 to 14 dB, the scheme can deliver an effective reuse factor of one, while permitting a given spectrum to be re-used in every sector of every cell. The scheme also offers flexible sector planning, easy capacity growth, and addresses irregular cell layout and non-uniform traffic density.
Pancreatitis and cytokines. (1997)

The pathogenesis of acute and chronic pancreatitis involves multiple mechanisms participating in the development of inflammation, necrosis and fibrosis. Cytokines able to modulate inflammatory process, tissue repair or fibrosis development have gained growing interest in this disease. This paper reviews the current knowledge about the role of cytokines in pancreatitis.
Fatal neutropenic colitis complicating successful chemotherapy for small cell lung cancer: a case report. (1995)

Neutropenic colitis, a severe necrotizing enteropathy, is being recognized with increasing frequency as a life-threatening complication of aggressive chemotherapy mainly for lymphoproliferative and hematologic malignancies. It is often under-recognized clinically, despite its potentially lethal outcome. Both medical and surgical approaches to management are possible. We describe a case of neutropenic colitis involving predominantly the transverse colon in a patient successfully treated for limited-disease small cell lung cancer. This is only the second reported case of neutropenic colitis complicating chemotherapy for small cell lung cancer. A brief review of the diagnosis, clinical features, and management is presented.
Development of a Series of (1-Benzyl-3-(6-methoxypyrimidin-3-yl)-5-(trifluoromethoxy)-1H-indol-2-yl)methanols as Selective Protease Activated Receptor 4 (PAR4) Antagonists with in Vivo Utility and Activity Against γ-Thrombin (2016)

Here, we describe the development of a series of highly selective PAR4 antagonists with nanomolar potency and selectivity versus PAR1, derived from the indole-based 3. Of these, 9j (PAR4 IC50 = 445 nM, PAR1 response IC50 > 30 μM) and 10h (PAR4 IC50 = 179 nM, PAR1 response IC50 > 30 μM) maintained an overall favorable in vitro DMPK profile, encouraging rat/mouse in vivo pharmacokinetics (PK) and activity against γ-thrombin.
Deterministic Column Sampling for Low-Rank Matrix Approximation: Nyström vs. Incomplete Cholesky Decomposition (2016)

Kernel matrices that encode the distance (or similarity) between data points are widely used throughout the computational sciences for classification, clustering, and dimensionality reduction. For large datasets, the cost of computing and factorizing such matrices becomes intractable. Thus instead of operating on the entire matrix, approximate methods such as the Nyström method and the incomplete Cholesky decomposition (ICD) generate a low rank matrix factorization using only a subset of the matrix columns (or rows). Here, we present an adaptive column sampling strategy for the Nyström method that we dub Accelerated Sequential Incoherence Selection (oASIS). This sampling strategy reveals a missing link between Nyström methods and ICD: we demonstrate that ICD is actually a special case of the Nyström method with the oASIS adaptive sampling rule. Numerical experiments and theoretical results suggest that oASIS achieves performance comparable to state-of-the-art greedy Nyström methods but with shorter runtimes and less memory consumption.
Evidence for nuclear internalisation of biocompatible [60]fullerene 1) (2013)

Abstract A [60]fullerene derivative has been synthesised that demonstrates the ability to enter the nuclear volume of a variety of mammalian cells. This property is unique and has not been previously observed for other types of fullerene derivatives. This ability may have important implications in its use for biomedical applications, such as non-viral gene therapy and cancer chemotherapy where delivery of active agents to the cell nucleus is desired.
Notice of Removal: Nanobubble contrast agents enhance ultrasound imaging of prostate tumors in mice (2017)

Removed.
Flexible folienbasierte resonante Schaltkreise zum Instrumententracking im MRT (2009)

Ziele: Das Tracking von Instrumenten für MR-gesteuerte Interventionen ist eine wesentliche Voraussetzung für die Durchführung minimal-invasiver Eingriffe. Hier werden folienbasierte, aktiv signalgebende Schwingkreise für die Verwendung zur MR-Instrumentenverfolgung vorgestellt, die mit einer Dicke von ca. 50µm auf Kathetern und anderen Interventionsinstrumenten eingesetzt werden können. Methode: Es wurden flexible resonante Schaltkreise entwickelt, die aus zwei elektroplattierten Goldschichten und zwei Polyimid-Schichten bestehen. Eine der Polyimidschichten wurde als dielektrisches Material zur Erzeugung der Kapazität des Schwingkreises genutzt. Neben einer Spule mit sechs Windungen und dem Hauptkondensator wurden mehrere kleinere, abtrennbare Kapazitäten verwendet, um den Schaltkreis auf die benötigte 1.5 T Resonanzfrenquenz von 63.9 Mhz abzustimmen. Nach der Stimmung wurden die Schaltkreise mit Parylene C beschichtet um eine Wasserbeständingkeit und Biokompatibiltät der Bauteile zu erreichen. Ergebnis: Verschiedene Typen von resonanten Schaltkreisen wurden konstruiert und in eine weniger als 50µm dicke Folie integriert. Die Bauteile wurden so gestaltet, dass die auf Kathetern mit einer Größe von minimal 5F Durchmesser verwendet werden können. Die Schaltkreise wurden an einem klinischen MR-Scanner getestet (Achieva 1.5T, Philips Medical Systems, Niederlande) und zeigten die für im MR eingesetzte Schwingkreise typische Signalanreicherung. Schlussfolgerung: Folienbasierte, flexible Schwingkreise funktionieren in einem klinischen Testaufbau. Die Integration der resonanten Schaltkreise in eine dünne Folie ermöglicht die einfache Platzierung auf Kathetern und anderen in der Intervention verwendeten Geräten ohne die Dicke der Instrumente wesentlich zu vergrößern. Weitere in- und ex-vivo Tests sind zur Bestimmung der klinischen Einsetzbarkeit notwendig und geplant.
Évolution de la teneur en eau des grains et détermination de la maturité physiologique du maïs-grain (Zea mays L.) (2008)

Le semis hâtif de mais-grain (Zea mays L.) permet generalement aux hybrides d'atteindre la maturite physiologique avant les gels meurtriers. Contrairement a d'autres especes, il est cependant difficile de determiner a l'aide de criteres visuels si le mais-grain a atteint la maturite physiologique. Certains indicateurs, tels l'observation de la ligne de maturite ou l'apparition du point noir, ont ete mis au point pour determiner la maturite physiologique du mais-grain. Certaines contraintes rendent difficiles leur utilisation dans le cadre des essais d'hybrides commerciaux comportant un nombre important de lignees ou de cultivars. Le suivi de l'evolution de la teneur en eau des grains au cours de la periode reproductive pourrait constituer une methode prometteuse pour determiner la maturite physiologique du mais-grain. Une etude de trois ans a permis (1) de verifier a l'aide de regression si l'evolution de la teneur en eau des grains varie de facon lineaire au cours de la seconde moitie de la periode reproductive du mais-grain, soit de la fin aout a la fin septembre, et (2) d'utiliser ces droites de regression lineaires afin de determiner precisement la maturite physiologique d'hybrides commerciaux de mais-grain adaptes aux diverses zones de croissance du Quebec variant de 2300 a 2900 unites thermiques mais (UTM). Les coefficients de regression lineaire ont ete superieurs a 0,800 (n = 1169) dans 99,3% des cas et l'apparition du point noir coincidait avec des teneurs en eau variant de 32 a 35%. Un echantillonnage aux 15 jours permettrait de determiner de maniere satisfaisante l'evolution de la teneur en eau des grains de meme que l'atteinte de la maturite physiologique du mais-grain pour les seuils de teneur en eau de 32 et de 35%.
Asymmetric Palladium‐Catalyzed Intramolecular α‐Arylation of Aldehydes (2008)

Phoxy ligand: The first catalytic method for the asymmetric palladium-catalyzed intramolecular α-arylation of α-branched aldehydes was developed (see scheme). This process is distinguished by the high yields and enantioselectivities that can be obtained, making this protocol a useful synthetic tool for further applications.
Abstract 3512: Measuring intracellular target engagement and drug residence time with nanoBRET (2015)

Abstract We present a biophysical method to directly measure target engagement within intact mammalian cells using bioluminescence energy transfer (BRET). Compound interactions with intracellular targets can be detected with complete specificity by their ability to compete with energy transfer complexes introduced into the cells. These complexes can be detected at physiologically relevant levels by exploiting an extraordinarily bright luciferase (NanoLuc), together with fluorescent tracers optimized for cell-permeability and spectral resolution from the luciferase. We demonstrate applications of the technology for target engagement among key drug target classes, including; kinases, histone deacetylases (HDACs), bromodomains, and the methyltransferase EZH2. Intracellular selectivity and affinity profiles of various reference compounds and approved drugs will be presented. For a panel of HDAC inhibitors, affinity profiles for specific HDAC isozymes strongly correlate with phenotypic potencies (e.g. cell viability). Furthermore, the luminescent output of the energy transfer complex enables a technique to monitor ligand occupancy in real-time. Association and dissociation rates can be derived from the kinetic measurements, providing a means to quantify drug residence time on select targets within intact cell populations. This novel application of intracellular BRET should significantly advance target engagement work flows, and allow for intracellular target affinities to be coupled to phenotypic outcomes. Citation Format: Matthew B. Robers, Melanie Dart, Chad Zimprich, Thomas Kirkland, Sergiy Levin, Thomas Machleidt, Jim Hartnett, Kris Zimmerman, Rachel Ohana, Danette Daniels, Mei Cong, Frank Fan, Keith Wood. Measuring intracellular target engagement and drug residence time with nanoBRET. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 3512. doi:10.1158/1538-7445.AM2015-3512
Insulator-like behavior coexisting with metallic electronic structure in strained FeSe thin films grown by molecular beam epitaxy (2019)

This paper reports that \ensuremath{\sim}10-nm-thick iron selenide (FeSe) thin films exhibit insulator-like behavior in terms of the temperature dependence of their electrical resistivity even though bulk FeSe has a metallic electronic structure that has been confirmed by photoemission spectroscopy and first-principles calculations. This apparent contradiction is explained by potential barriers formed in the conduction band. Very thin FeSe epitaxial films with various atomic composition ratios ([Fe]/[Se]) were fabricated by molecular beam epitaxy and classified into two groups with respect to lattice strain and electrical properties. Lattice parameter $a$ increased and lattice parameter $c$ decreased with increasing [Fe]/[Se] up to 1.1 and then $a$ leveled off and $c$ began to decrease at higher [Fe]/[Se]. Consequently, the FeSe films had the most strained lattice when [Fe]/[Se] was 1.1, but these films had the best quality with respect to crystallinity and surface flatness. All the FeSe films with [Fe]/[Se] of 0.8--1.9 exhibited insulator-like behavior, but the temperature dependences of their electrical resistivities exhibited different activation energies ${E}_{\mathrm{a}}$ between the Se-rich and Fe-rich regions; i.e., ${E}_{\mathrm{a}}$ were small (a few meV) up to $[\mathrm{Fe}]/[\mathrm{Se}]=1.1$ but jumped up to \ensuremath{\sim}25 meV at higher [Fe]/[Se]. The film with $[\mathrm{Fe}]/[\mathrm{Se}]=1.1$ had the smallest ${E}_{\mathrm{a}}$ of 1.1 meV and exhibited an insulator--superconducting transition at 35 K with zero resistance under gate bias. The large ${E}_{\mathrm{a}}$ of the Fe-rich films was attributed to the unusual lattice strain with tensile in-plane and relaxed out-of-plane strains. The large ${E}_{\mathrm{a}}$ of films with [Fe]/[Se] &gt; 1.1 resulted in low mobility with a high potential barrier of \ensuremath{\sim}50 meV in the conduction band for percolation carrier conduction compared with that of the $[\mathrm{Fe}]/[\mathrm{Se}]=1.1$ film (\ensuremath{\sim}17 meV). Therefore, the Fe-rich films exhibited remarkable insulator-like behavior similar to a semiconductor despite their metallic electronic structure. The high potential barrier of Fe-rich films is tentatively attributed to the presence of large amounts of excess Fe, which could plausibly cause a broad superconducting transition without zero resistance under gating.
A routing coordination protocol in a loosely-coupled massively parallel router (2003)

In this paper, we present an efficient routing coordination based protocol which makes use of a scalable high-performance router based upon a cluster of autonomous routers to handle the routing problems raised by the current Internet growth. We also discuss a novel proprietary protocol, which we refer to as Galaxy/spl trade/ Loosely-coupled Unified Environment (or GLUE). This protocol is based upon the idea of the open shortest path first (OSPF) routing protocol. It helps the autonomous routers to maintain a consistent routing table, and monitors the status of each router using an efficient message exchange mechanism.
Conjugation of nitrated acetaminophen to Der p1 amplifies peripheral blood monocyte response to Der p1 (2017)

These data suggests 3-nitro-acetaminophen formation and reaction with Der p1 provides a mechanism by which stomach acid or infection-induced low airway pH in patients could enhance the allergic response to proteins such as Der p1.
[Domestic infection of neurocysticercosis in a Japanese woman, who had not travelled overseas]. (1995)

A 52-year-old Japanese woman was found to have a single parenchymal cystic lesion in the operculum of the left frontal lobe. Although she had not travelled overseas, neuroradiological and serological studies supported the diagnosis of neurocysticercosis. Three months after a trial with praziquantel, although the cystic lesion decreased in size on MR imagings, she suddenly developed motor dominant aphasia as a manifestation of epileptic attack. This appears to have followed the death of the cysticercus, releasing the cysticercus contents into the surrounding brain and to have stimulated an intense reactive inflammation. Neurocysticercosis, although rare in Japan, may be positively identified by neuroimaging and serological studies and can be treated conservatively with praziquantel.
Thermal Stability of Cu/Co Metaconductor and Its Millimeter Wave Applications (2018)

This work presents a study on the thermal stability of metaconductors made of copper and cobalt (Cu/Co) alternating layers in comparison with that of ones made of copper and nickel (Cu/Ni) alternating layers. Very slow anneals over several hours have been performed for both types of metaconductors. The experimental results show that after cooling down from annealing to 425 °C, Cu/Co metaconductors retain 78 % of the original magnetization, and are able to regain the original magnetization with an applied magnetic field of 50 kA/m or less. Cu/Ni metaconductors, however, lose nearly all magnetization in addition to having altered ferromagnetic properties after annealing at the same temperature. It is concluded that Cu/Co metaconductors show a superior thermal stability to Cu/Ni ones.