gebhart/patrepeval huggingface dataset:
Heterochromatin: stable and unstable invasions at home and abroad (2003)

One of the most vibrant areas of biology at present concerns elucidation of the “epigenetic” molecular mechanisms underlying how genomes are packaged to facilitate heritable gene expression patterns. An explosion of recent findings reveals how various components of chromatin regulate this process. Especially exciting is the dynamic role played by histone posttranslational modifications, which some have termed the “histone code” (Strahl and Allis 2000; Jenuwein and Allis 2001; Kouzarides 2002). Equally important are the proteins that read this code and interpret the signals to modulate transcriptional potential (Eissenberg and Elgin 2000; Lachner et al. 2001). Much of what we have learned about these molecular parameters has come from the study of large regions of DNA packaged into, and heritably transmitted as, permanently transcriptionally silenced regions termed constitutive heterochromatin (Wakimoto 1998; Grewal and Elgin 2002). In classic studies with Drosophila, molecular determinants have been elucidated to explain variegated patterns of heritable gene expression, or position effect variegation (PEV), which emerge when a gene that normally resides in active euchromatin is translocated into such heterochromatin (Wallrath and Elgin 1995; Wakimoto 1998; Grewal and Elgin 2002). In this issue of Genes & Development, a clever experimental system initially designed to explore the role of heterochromatin in the silencing of specific genes unexpectedly reveals that the opposite situation, invasion of heterochromatin into a euchromatic region, also triggers a variegated pattern of heritable gene silencing (Ayyanathan et al. 2003). These findings have important ramifications for gene expression in settings of both normal and pathological cellular function.
Neutral bimetallic transition metal phenoxyiminato catalysts and related polymerization methods (2023)

A catalyst composition comprising a neutral bimetallic diphenoxydiiminate complex of group 10 metals or Ni, Pd or Pt is disclosed. The compositions can be used for the preparation of homo- and co-polymers of olefinic monomer compounds.
SUM FREQUENCY GENERATION IN A CO-PROPAGATING BEAM GEOMETRY FROM THIN FILMS (2007)

Author Institution: Department of Physics and Astronomy \& Forest Bioproducts Research Institute,; University of Maine, Orono, ME 04469 USA; Department of Chemical and Biological Engineering, University of Maine, Orono, ME 04469 USA
The Activation Pattern of Blood Leukocytes in Head and Neck Squamous Cell Carcinoma Is Correlated to Survival (2012)

Head and neck squamous cell carcinoma (HNSCC) is known to cause substantial immunosuppression. The present study was designed to characterize blood leukocyte activation in HNSCC and to investigate if the individual activation pattern could be related to tumor progress and survival. The leukocyte activation profile of HNSCC patients and healthy controls was assessed with flow cytometry. HNSCC patients displayed increased numbers of monocytes, neutrophils and total leukocytes as well as an enhanced neutrophil/lymphocyte ratio. In addition, patients had a higher percentage of CD69(+), CD71(+) and CD98(+) T cell subsets and NK cells, and a reduced expression of L-selectin in CD14(high)CD16(+) monocytes and neutrophils, when compared to controls. These changes could be correlated to both tumor burden and spread to lymph nodes. Among the cancer patients an increased neutrophil/lymphocyte ratio, a low neutrophil and CD14(high) CD16(+) monocyte activation state and an elevated CD4/CD8 ratio were related to poor survival. In contrast, a high percentage of CD98(+) Th cells appeared to be associated with a better outcome. Taken together, the present data indicate that HNSCC causes activation of blood leukocytes and that the individual activation pattern can be linked to prognosis.
A study on the role of powertrain system dynamics on vehicle driveability (2017)

Vehicle driveability describes the complex interactions between the driver and the vehicle, mainly related to longitudinal vibrations. Today, a relevant part of the driveability process optimisation is realised by means of track tests, which require a considerable effort due to the number of parameters (such as stiffness and damping components) affecting this behaviour. The drawback of this approach is that it is carried on at a stage when a design iteration becomes very expensive in terms of time and cost. The objective of this work is to propose a light and accurate tool to represent the relevant quantities involved in the driveability analysis, and to understand which are the main vehicle parameters that influence the torsional vibrations transmitted to the driver. Particular attention is devoted to the role of the tyre, the engine mount, the dual mass flywheel and their possible interactions. The presented nonlinear dynamic model has been validated in time and frequency domain and, through linearisation of its nonlinear components, allows to exploit modal and energy analysis. Objective indexes regarding the driving comfort are additionally considered in order to evaluate possible driveability improvements related to the sensitivity of powertrain parameters.
Hydrocarbon formation from methanol using WO3/Al2O3 and zeolite H-ZSM-5 catalysts: further evidence on the reaction mechanism (1987)

Reaction of methanol with and without added hydrogen using the title catalysts gives no significant changes in the product spectrum providing strong evidence against non-bonded methylene being the active intermediate for carbon–carbon bond formation.
Supplementary Table 3 from Transcriptional Profiling Identifies Cyclin D1 as a Critical Downstream Effector of Mutant Epidermal Growth Factor Receptor Signaling (2023)

Supplementary Table 3 from Transcriptional Profiling Identifies Cyclin D1 as a Critical Downstream Effector of Mutant Epidermal Growth Factor Receptor Signaling
Langerhans dendritic cell vaccine bearing mRNA-encoded tumor antigens induces antimyeloma immunity after autotransplant (2022)

Posttransplant vaccination targeting residual disease is an immunotherapeutic strategy to improve antigen-specific immune responses and prolong disease-free survival after autologous stem cell transplantation (ASCT) for multiple myeloma (MM). We conducted a phase 1 vaccine trial to determine the safety, toxicity, and immunogenicity of autologous Langerhans-type dendritic cells (LCs) electroporated with CT7, MAGE-A3, and Wilms tumor 1 (WT1) messenger RNA (mRNA), after ASCT for MM. Ten patients received a priming immunization plus 2 boosters at 12, 30, and 90 days, respectively, after ASCT. Vaccines contained 9 × 106 mRNA-electroporated LCs. Ten additional patients did not receive LC vaccines but otherwise underwent identical ASCT and supportive care. At 3 months after ASCT, all patients started lenalidomide maintenance therapy. Vaccinated patients developed mild local delayed-type hypersensitivity reactions after booster vaccines, but no toxicities exceeded grade 1. At 1 and 3 months after vaccines, antigen-specific CD4 and CD8 T cells increased secretion of proinflammatory cytokines (interferon-γ, interleukin-2, and tumor necrosis factor-α) above prevaccine levels, and also upregulated the cytotoxicity marker CD107a. CD4 and CD8 T-cell repertoire analysis showed a trend for increased clonal expansion in the vaccine cohort, which was more pronounced in the CD4 compartment. Although not powered to assess clinical efficacy, treatment responses favored the vaccine arm. Triple antigen-bearing mRNA-electroporated autologous LC vaccination initiated at engraftment after ASCT, in conjunction with standard lenalidomide maintenance therapy for MM, is safe and induces antigen-specific immune reactivity. This trial was registered at www.clinicaltrials.gov as #NCT01995708.
Novel Dual-Band Microwave Filter Using Dual-Capacitively-Loaded Cavity Resonators (2010)

We present a novel design concept for low-loss dual-band cavity filters based on dual-capacitively-loaded (DCL) cavity resonators. The relatively independent control over the center frequencies, inter-resonator and external coupling coefficients makes the DCL resonator an ideal building block for dual-band filters with widely separated passbands. The high unloaded quality factor (Q <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">u</sub> ) of the DCL cavity resonator ensures a low insertion loss. An example 2-pole dual-band filter at 2.4 and 5.0 GHz is demonstrated with an insertion loss of 1.47 dB at 2.4 GHz, 1.01 dB at 5.0 GHz and a bandwidth of 24.8 MHz (~1%) at 2.4 , and 51.2 MHz (~1%) at 5.0 GHz.
Constitutive Modeling of a Thermoplastic Olefin Over a Broad Range of Strain Rates (2006)

A microstructually motivated, three-dimensional, large deformation, strain rate dependent constitutive model has been developed for a semi-crystalline, blended, thermoplastic olefin (TPO) (Wang, Y., 2002, Ph.D. thesis, The University of Michigan, Ann Arbor, MI). Various experiments have been conducted to characterize the TPO and to verify the modeling approach (Wang, Y., 2002, Ph.D. thesis, The University of Michigan, Ann Arbor, MI). The model includes a quantitative rate-dependent Young’s modulus, a nonlinear viscoelastic response between initial linear elastic response and yield due to inherent microstructural irregularity, rate and temperature dependent yield with two distinctive yield mechanisms for low and high strain rates, temperature-dependent strain hardening, plastic deformation of crystalline regions, and adiabatic heating. It has been shown to accurately capture the observed TPO stress-strain behavior including the rate-dependent initial linear elastic response; temperature, strain rate, and deformation state-dependent yield; temperature and deformation state-dependent strain hardening; and pronounced thermal softening effects at high (impact) strain rates. The model has also been examined for its ability to predict the response in plane strain compression based on material parameters chosen to capture the uniaxial compression response. The model is predictive of the initial strain rate dependent stiffness, yield, and strain hardening responses in plane strain. Such predictive capability demonstrates the versatility with which this model captures the three-dimensional anisotropic nature of TPO stress-strain behavior.
NVH Simulation Technology for Disc Brake Calipers (2009)

INTRODUCTION IN recent years, although the dynamic performance of automobiles has improved radically, demand has been growing at the same time for both comfort and silence. This need for further improvements includes a reduction in the noise and vibration that can occasionally occur during braking, and which can give car occupants a feeling of discomfort. Independent organizations have been conducting vehicle evaluations to determine customer satisfaction levels recently, including the surveys of J. D. Power and Associates in the USA and the automotive magazine “auto, motor und sport” in Germany. Poor evaluation results in these surveys are a major problem because they lead to reduced vehicle sales while causing damage to the automobile manufacturer’s brand image. Since brake noise and vibration are among the items evaluated in these surveys, further improvement is needed in these areas as well. The phenomena that cause these problems are complicated, and clarifying the mechanisms involved is a vital part of the improvement process. This document describes the efforts of Hitachi with respect to technologies for analyzing NVH (noise, vibration, and harshness, whereby “harshness” refers to a lack of smoothness in the ride) caused by automobile disc brakes.
Quantum computational quantification of protein–ligand interactions (2022)

Abstract We have demonstrated a prototypical hybrid classical and quantum computational workflow for the quantification of protein–ligand interactions. The workflow combines the density matrix embedding theory (DMET) embedding procedure with the variational quantum eigensolver (VQE) approach for finding molecular electronic ground states. A series of ‐secretase (BACE1) inhibitors is rank‐ordered using binding energy differences calculated on the latest superconducting transmon (IBM) and trapped‐ion (Quantinuum) noisy intermediate scale quantum (NISQ) devices. This is the first application of real quantum computers to the calculation of protein‐ligand binding energies. The results shed light on hardware and software requirements which would enable the application of NISQ algorithms in drug design.
Wideband Channel Estimation for Hybrid Beamforming Millimeter Wave\n Communication Systems with Low-Resolution ADCs (2017)

A potential tremendous spectrum resource makes millimeter wave (mmWave)\ncommunications a promising technology. High power consumption due to a large\nnumber of antennas and analog-to-digital converters (ADCs) for beamforming to\novercome the large propagation losses is problematic in practice. As a hybrid\nbeamforming architecture and low-resolution ADCs are considered to reduce power\nconsumption, estimation of mmWave channels becomes challenging. We evaluate\nseveral channel estimation algorithms for wideband mmWave systems with hybrid\nbeamforming and low-resolution ADCs. Through simulation, we show that 1)\ninfinite bit ADCs with least-squares estimation have worse channel estimation\nperformance than do one-bit ADCs with orthogonal matching pursuit (OMP) in an\nSNR range of interest, 2) three- and four-bit quantizers can achieve channel\nestimation performance close to the unquantized case when using OMP, 3) a\nreceiver with a single RF chain can yield better estimates than that with four\nRF chains if enough frames are exploited, and 4) for one-bit ADCs, exploitation\nof higher transmit power and more frames for performance enhancement adversely\naffects estimation performance after a certain point.\n
The Lexicon Builder Web service: Building Custom Lexicons from two hundred Biomedical Ontologies. (2010)

Domain specific biomedical lexicons are extensively used by researchers for natural language processing tasks. Currently these lexicons are created manually by expert curators and there is a pressing need for automated methods to compile such lexicons. The Lexicon Builder Web service addresses this need and reduces the investment of time and effort involved in lexicon maintenance. The service has three components: Inclusion - selects one or several ontologies (or its branches) and includes preferred names and synonym terms; Exclusion - filters terms based on the term's Medline frequency, syntactic type, UMLS semantic type and match with stopwords; Output - aggregates information, handles compression and output formats. Evaluation demonstrates that the service has high accuracy and runtime performance. It is currently being evaluated for several use cases to establish its utility in biomedical information processing tasks. The Lexicon Builder promotes collaboration, sharing and standardization of lexicons amongst researchers by automating the creation, maintainence and cross referencing of custom lexicons.
Spectrin self-association site: characterization and study of β-spectrin mutations associated with hereditary elliptocytosis (1998)

Most of hereditary elliptocytosis (HE) cases are related to a spectrin dimer (SpD) self-association defect. The severity of haemolysis is correlated with the extent of the SpD self-association defect, which itself depends on the location of the mutation regarding the tetramerization site. This site is presumed to involve the first C helix of the alpha chain and the last two helices, A and B, of the beta chain to reconstitute a triple helical structure (A, B and C), as observed along spectrin. Using recombinant peptides, we demonstrated that the first C helix of the alpha chain and the last two helices of the beta chain alone are not sufficient to establish interactions, which only occurred when a complete triple-helical repeat was added to each partner. One adjacent repeat is necessary to stabilize the conformation of both N- and C-terminal structures directly involved in the interaction site and is sufficient to generate a binding affinity similar to that observed in the native molecule. Producing peptides carrying a betaHE mutation, we reproduced the tetramerization defect as observed in patients. Therefore, the betaW2024R and betaW2061R mutations, which replace the invariant tryptophan and a residue located in the hydrophobic core, respectively, affect alpha-beta interactions considerably. In contrast, the betaA2013V mutation, which modifies a residue located outside any presumed interacting regions, has a minor effect on the interaction.
Prediction of Warfarin Dose Reductions in Puerto Rican Patients, Based on Combinatorial CYP2C9 and VKORCI Genotypes (2012)

This study laid important groundwork for supporting a prospective pharmacogenetic trial in Puerto Ricans to detect the benefits of incorporating relevant genomic information into a customized DNA-guided warfarin dosing algorithm.
ChemInform Abstract: Lifetimes of Alkyl and Dialkyl Carbenes in Solution (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The Effect of DC Bias Conditions on Ferrite Core Losses (2008)

In switched-mode power supplies - the predominant type of power converter in contemporary electronic equipment - ferrite magnetic components under dc bias conditions are typically large and have relatively high losses. The nature of these losses is not widely understood, and research in this area has been hampered by the difficulty of obtaining accurate core loss measurements. This paper reviews previous studies on the nature of core losses under dc bias, and presents new results, measured by a technique that has not previously been utilized for the measurement of core losses under dc bias conditions. The results show that ferrite core losses increase significantly with an increasing dc bias, and highlight the need for further research over a wider range of conditions to fully characterize the phenomenon.
Investigation of Cross-Section Measurement Method for All-Solid-State Batteries Using Terahertz Chemical Microscopy (2021)

In recent years, all-solid-state batteries have been attracting attention as secondary batteries to replace Li ion batteries. To improve the performance of all-solid-state batteries, measurement methods are required to evaluate electrode-solid electrolyte interfaces and electrochemical reactions between electrodes. In this study, we investigated a measurement method for the cross-section of all-solid-state batteries using terahertz chemical microscopy (TCM). We fabricated a model of all-solid-state battery and showed the possibility of using TCM to measure the cross-section of the all-solid-state battery by measuring the cross-section of a model of all-solid-state battery.
Police Constable S. Roberts and friend (2016)

A black and white photograph portraying Police Constable, S. Roberts and his friend standing in front of his house. - Μια ασπρόμαυρη φωτογραφία που απeικονίζeι τον αστυφύλακα, S. Roberts και έναν φίλο του να στέκονται μπροστά από το σπίτι του.
The Murine Kupffer Cell (1979)

Abstract Murine Kupffer cells, the tissue macrohages of the liver, were isolated by collagenase digestion, differential sedimentation over Metrizamide, and glass adherence. The resultant cell population was more than 86% phagocytic, and 95% of cell stained positively for α-naphtyl butyratc esterase activity. The cells also had cell surface receptors for complement (C) and the Fc portion of IgG. In additon, a large proportion of Kupffer cells was shown to bear Ia antigens: about half of the cells bore I-A subregion-encoded antigens. Kupffer cell populations were capable of reconstituting antigen-stumulated proliferative responses of antigen-primed, macrophage-depleted, lymph node T cells. The ability to reconstitute proliferation was enriched in the adheren population and was resistant to radiation and treatment with an anti-Thy antiserum and C. We conclude that isolated murine Kupffer cells bear the Ia phenotype of accessory cells that function in antigen presentation and that Kupffer cells can paricipate in the induction of antigen-specific immune responses. These data suggest that Kupffer cells may play a role in modulating responses to enterically derived antigens.
Quantization of the electromagnetic field on static space–times (1995)

A quantization of the electromagnetic four-potential in the Lorentz gauge on static space–times with compact Cauchy surfaces is developed herein. For the classical problem, the field solution is obtained by use of a Hilbert space approach in which time evolution reduces to a unitary mapping of Cauchy data. For the quantum problem, a representation of the CCRs on a Fock space is constructed. The gauge condition is imposed as a constraint on state vectors and determines a physical subspace. The field equations are recovered on the physical Fock space (Gupta–Bleuler method).
Complete peptide mapping of membrane proteins (2002)

Conclusions Integral membrane proteins play vital roles in many cellular and physiological processes. Due to their hydrophobic nature, characterization of the integral membrane proteins is very difficult. Surfactants are typically used to enhance protein solubility prior to enzymatic digestion. However, introduction of surfactant usually causes reduction in proteolytic enzyme activity and compromises the downstream liquid chromatography and mass spectrometry analysis. We applied a novel acid degradable surfactant, RapiGest SF, to improve the solubility of a model membrane protein, Bacteriorhodopsin (BR) upon enzymatic digestion. Observed peptides from LC/MS analysis cover 99% of the protein sequence.
Sugars Can Actually Be Good For Your Health (LBNL Science at the Theater) (2009)

Like peanut M&Ms, all cells are coated with sugars but the functions of these sugar coatings were a mystery until very recently. This presentation will highlight recent fascinating discoveries regarding why cells are coated with sugars, as well as new tools for cancer detection that take advantage of the cells sugar coating. Professor Bertozzis lab focuses on profiling changes in cell surface glycosylation associated with cancer, inflammation and bacterial infection, and exploiting this information for development of diagnostic and therapeutic approaches. In addition, her group develops nanoscience-based technologies for probing cell function and for medical diagnostics.
Failure Mechanism in Thick Film Materials for 300$~{}^{\circ}{\rm C}$ Operation (2012)

Geothermal well logging and instrumentation applications require electronics capable of operation at 300°C. SiC device technology enables the design and fabrication of analog circuits that can operate at these temperatures. However, to build functional systems that can operate at high temperatures, an interconnection and packaging technology must be developed to provide interconnectivity between different SiC devices and passive components. Thick film technology based on metals, glasses, and ceramics has the potential for high operating temperatures. The effect of biased 300°C storage on leakage current and the adhesion of different thick film conductors and multilayer dielectrics has been studied. Mobility of glass modifiers at 300°C has been shown to result in leakage current and adhesion loss.
Supplementary Table 1 from A Novel Antiandrogen, Compound 30, Suppresses Castration-Resistant and MDV3100-Resistant Prostate Cancer Growth <i>In Vitro</i> and <i>In Vivo</i> (2023)

&lt;p&gt;PDF, 49K, AR transcriptional activity EC50 in LNCaP cells treated with MDV3100 and Compound 30&lt;/p&gt;