gebhart/patrepeval huggingface dataset:
Multiple Adaptive Mechanisms to Chronic Liver Disease Revealed at Early Stages of Liver Carcinogenesis in the Mdr2-Knockout Mice (2006)

Molecular events preceding the development of hepatocellular carcinoma were studied in the Mdr2-knockout (Mdr2-KO) mice. These mice lack the liver-specific P-glycoprotein responsible for phosphatidylcholine transport across the canalicular membrane. Portal inflammation ensues at an early age followed by hepatocellular carcinoma development after the age of 1 year. Liver tissue samples of Mdr2-KO mice in the early and late precancerous stages of liver disease were subjected to histologic, biochemical, and gene expression profiling analysis. In an early stage, multiple protective mechanisms were found, including induction of many anti-inflammatory and antioxidant genes and increase of total antioxidant capacity of liver tissue. Despite stimulation of hepatocyte DNA replication, their mitotic activity was blocked at this stage. In the late stage of the disease, although the total antioxidant capacity of liver tissue of Mdr2-KO mice was normal, and inflammation was less prominent, many protective genes remained overexpressed. Increased mitotic activity of hepatocytes resulted in multiple dysplastic nodules, some of them being steatotic. Expression of many genes regulating lipid and phospholipid metabolism was distorted, including up-regulation of choline kinase A, a known oncogene. Many other oncogenes, including cyclin D1, Jun, and some Ras homologues, were up-regulated in Mdr2-KO mice at both stages of liver disease. However, we found no increase of Ras activation. Our data suggest that some of the adaptive mechanisms induced in the early stages of hepatic disease, which protect the liver from injury, could have an effect in hepatocarcinogenesis at later stages of the disease in this hepatocellular carcinoma model.
4,7‐Dimethoxy‐1,10‐phenanthroline: An Excellent Ligand for the Cu‐Catalyzed N‐Arylation of Imidazoles. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Beta-hydroxybutyrate dampens adipose progenitors’ profibrotic activation through canonical Tgfβ signaling and non-canonical ZFP36-dependent mechanisms (2022)

These data unravel the potential of β-hydroxybutyrate to limit adipose tissue matrix deposition, a finding that might exploited in an obesogenic context.
Branching Fraction Measurements of the Rare Bs0→ϕμ+μ− and Bs0→f2′(1525)μ+μ− Decays (2021)

The branching fraction of the rare B_{s}^{0}→ϕμ^{+}μ^{-} decay is measured using data collected by the LHCb experiment at center-of-mass energies of 7, 8, and 13 TeV, corresponding to integrated luminosities of 1, 2, and 6 fb^{-1}, respectively. The branching fraction is reported in intervals of q^{2}, the square of the dimuon invariant mass. In the q^{2} region between 1.1 and 6.0 GeV^{2}/c^{4}, the measurement is found to lie 3.6 standard deviations below a standard model prediction based on a combination of light cone sum rule and lattice QCD calculations. In addition, the first observation of the rare B_{s}^{0}→f_{2}^{'}(1525)μ^{+}μ^{-} decay is reported with a statistical significance of 9 standard deviations and its branching fraction is determined.
Sulfide oxidation tuning in 4,8-bis(5-(2-ethylhexyl)thiophen-2-yl)benzo[1,2-b:4,5-b′]dithiophene based dual acceptor copolymers for highly efficient photocatalytic hydrogen evolution (2022)

A sulfide oxidation tuning approach in BDTT is reported for constructing a series of dual acceptor 1-2 (A 1 –A 2 )-type copolymers. PBDTTS-1SO achieved an outstanding HER, demonstrating that the immense potential of the A 1 -A 2 -type polymer photocatalysts.
Small, aloricate ciliates as a major component of the marine heterotrophic nanoplankton1 (1986)

Small, aloricate ciliates with equivalent spherical cell diameters &lt;20 µ m (biovolume &lt;4,000 µ m 3 ) compose, on average, 4–57% of the total biomass of heterotrophic (apochlorotic) nanoplankton in diverse marine systems. Biomass production of nanoplanktonic ciliates in a southeastern U.S. estuary was also a significant part of the total production of heterotrophic microprotozoa. During summer in a salt marsh tidal creek, the production of small ciliates exceeded the production of heterotrophic microflagellates. Bacteria and coccoid cyanobacteria were frequently observed in the food vacuoles of the ciliates, while ingested nanoplanktonic algae were rarely seen. We suggest that small, aloricate ciliates can be an important component of the biomass of heterotrophic nanoplankton and deserve further attention as potential consumers of picoplanktonic cells in marine pelagic systems.
Phosphatidylinositol 3-kinase-dependent activation of trypsinogen modulates the severity of acute pancreatitis (2001)

Intra-acinar cell activation of digestive enzyme zymogens including trypsinogen is generally believed to be an early and critical event in acute pancreatitis. We have found that the phosphatidylinositol 3-kinase inhibitor wortmannin can reduce the intrapancreatic activation of trypsinogen that occurs during two dissimilar experimental models of rodent acute pancreatitis, secretagogue- and duct injection-induced pancreatitis. The severity of both models was also reduced by wortmannin administration. In contrast, the NF-κB activation that occurs during the early stages of secretagogue-induced pancreatitis is not altered by administration of wortmannin. Ex vivo, caerulein-induced trypsinogen activation is inhibited by wortmannin and LY294002. However, the cytoskeletal changes induced by caerulein were not affected by wortmannin. Concentrations of caerulein that induced ex vivo trypsinogen activation do not significantly increase phosphatidylinositol-3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate levels or induce phosphorylation of Akt/PKB, suggesting that class I phosphatidylinositol 3-kinases are not involved. The concentration of wortmannin that inhibits trypsinogen activation causes a 75% decrease in phosphatidylinositol 3-phosphate, which is implicated in vesicle trafficking and fusion. We conclude that a wortmannin-inhibitable phosphatidylinositol 3-kinase is necessary for intrapancreatic activation of trypsinogen and regulating the severity of acute pancreatitis. Our observations suggest that phosphatidylinositol 3-kinase inhibition might be of benefit in preventing acute pancreatitis.
A NEW PERFORMANCE-BASED DESIGN METHODOLOGY FOR CONTROLLED ROCKING STEEL FRAMES (2014)

A NEW PERFORMANCE-BASED DESIGN METHODOLOGY FOR CONTROLLED ROCKING STEEL FRAMES - 4th International Conference on Computational Methods in Structural Dynamics and Earthquake Engineering - 12-14 June 2013 - Kos Island Greece
Bandit-Based Power Control in Full-Duplex Cooperative Relay Networks With Strict-Sense Stationary and Non-Stationary Wireless Communication Channels (2022)

Full-duplex relaying is an enabling technique of sixth generation (6G) mobile networks, promising tremendous rate and spectral efficiency gains. In order to improve the performance of full-duplex communications, power control is a viable way of avoiding excessive loop interference at the relay. Unfortunately, power control requires channel state information of source-relay, relay-destination and loop interference channels, thus resulting in increased overheads. Aiming to offer a low-complexity alternative for power control in such networks, we adopt reward-based learning in the sense of multi-armed bandits. More specifically, we present bandit-based power control, relying on acknowledgements/negative-acknowledgements observations by the relay. Our distributed algorithms avoid channel state information acquisition and exchange, and can alleviate the impact of outdated channel state information. Two cases are examined regarding the channel statistics of the wireless network, namely, strict-sense stationary and non-stationary channels. For the latter, a sliding window approach is adopted to further improve the performance. Performance evaluation highlights a performance-complexity trade-off, compared to optimal power control with full channel knowledge and significant gains over cases considering channel estimation and feedback overheads, outdated channel knowledge, no power control and random power level selection. Finally, it is shown that the sliding-window bandit-based algorithm provides improved performance in non-stationary settings by efficiently adapting to abrupt changes of the wireless channels.
One-Pot Four-Component Reaction:  Aqueous TiCl3/PhN2+-Mediated Alkyl Radical Addition to Imines Generated in Situ (2005)

Ti(III)-induced free-radical decomposition of a phenyldiazonium salt, followed by phenyl radical iodine-atom abstraction from alkyl iodides, leads to a one-pot selective alkyl radical addition to the C-atom of imines generated in situ under aqueous acidic conditions. [reaction: see text]
ChemInform Abstract: TRANSIENT FERRACYCLOBUTANES DURING PROTONATION OF η3‐HOMOALLYLIRON(0) COMPLEXES (1985)

Abstract Die nucleophile Addition einer Li‐Verbindung an die Komplexe (I) liefert reaktive intermedilre anionische Komplexe (II), die sich über Kohlenstoff‐ oder Wasserstoffverschiebu‐ng zu (IIIa) bzw. (IIIb) umlagem; protolytische Spaltung mit (lberschüssiger Trifluoressigsäure führt zu den Produkten (IV) bzw. (V) oder (VI).
ChemInform Abstract: Synthesis and in vitro Antimicrobial Activity of 3‐ Heteroarylsulfonylmethyl Cephems: A New Class of Cephalosporins. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
EllSeg-Gen, towards Domain Generalization for Head-Mounted Eyetracking (2022)

The study of human gaze behavior in natural contexts requires algorithms for gaze estimation that are robust to a wide range of imaging conditions. However, algorithms often fail to identify features such as the iris and pupil centroid in the presence of reflective artifacts and occlusions. Previous work has shown that convolutional networks excel at extracting gaze features despite the presence of such artifacts. However, these networks often perform poorly on data unseen during training. This work follows the intuition that jointly training a convolutional network with multiple datasets learns a generalized representation of eye parts. We compare the performance of a single model trained with multiple datasets against a pool of models trained on individual datasets. Results indicate that models tested on datasets in which eye images exhibit higher appearance variability benefit from multiset training. In contrast, dataset-specific models generalize better onto eye images with lower appearance variability.
The electrical assessment of Si1-xGex/Si heterostructures (1998)

A comprehensive electrical characterisation of the SiGe/Si heterostructures has been performed in the wide temperature range (10-270 K). For this study the structures fabricated by the ion implantation technique at three different substrate temperatures (room temperature, 150 C and 450 C) have been used. The presence and parameters of shallow and deep levels and the diode performance were studied as a function of the substrate temperature. The sample implanted at 450 C shows the best diode operation reflecting the higher quality of the surface silicon layer as compared to RT- and 150 C-implanted samples. For the first time the cryogenic TSCR technique has been applied to this system which makes it possible to investigate strain in the silicon layer due to SiGe layer formation.
High-pressure torsion for new hydrogen storage materials (2018)

High-pressure torsion (HPT) is widely used as a severe plastic deformation technique to create ultrafine-grained structures with promising mechanical and functional properties. Since 2007, the method has been employed to enhance the hydrogenation kinetics in different Mg-based hydrogen storage materials. Recent studies showed that the method is effective not only for increasing the hydrogenation kinetics but also for improving the hydrogenation activity, for enhancing the air resistivity and more importantly for synthesizing new nanostructured hydrogen storage materials with high densities of lattice defects. This manuscript reviews some major findings on the impact of HPT process on the hydrogen storage performance of different titanium-based and magnesium-based materials.
Recombinant retroviruses that transduce individual polyoma tumor antigens: effects on growth and differentiation. (1986)

We have constructed infectious retroviral vectors, derived from Moloney murine leukemia virus, that efficiently transduce the polyoma virus tumor (T) antigens individually. The parental vector we have chosen [pZIP-NeoSV(X)1] expresses a dominant selectable marker for neomycin resistance and is a shuttle vector capable of propagation in both eukaryotic and prokaryotic cells, thus facilitating its use in structure-function studies. To address the relationship between polyoma T-antigen tumorigenesis and the effects of individual T antigens on growth control and differentiation, we used these vectors to introduce and stably express large, middle-sized, or small T antigens into mouse fibroblasts and preadipocytes. All cDNAs introduced into the vector are expressed stably even in the absence of selective pressure. The stable expression of small T antigen is noted particularly because cell lines expressing small T antigen have not been readily available prior to the use of retroviral vectors. Small T antigen-induced increase in saturation density of NIH 3T3 cells can be scored on the basis of the morphology of drug-resistant colonies. Middle-sized T antigen eliminates the growth requirement of NIH 3T3 cells for epidermal growth factor in a defined medium and permits growth in platelet-poor plasma, indicating elimination of the platelet-derived growth factor requirement as well. Large T antigen suppresses mouse preadipocyte (3T3-F442A) differentiation. These vectors and these functional assays of T-antigen activity permit genetic analysis of the relationship between tumorigenesis by T antigens and the alteration of cellular growth and differentiation.
Implementing a Sensor Database System using a Generic Data Dissemination Mechanism. (2005)

The vision of a sensor network as a database has been reasonably well explored in the recent literature. Several sensor database systems have been prototyped [1, 11], and some have even been deployed [2]. However, these systems have largely integrated the query processing and the routing mechanisms. In this paper, we explore the design and implementation of a sensor database system (specifically, TinyDB [11]) on top of a generic sensor network data dissemination mechanism (Directed Diffusion [8]). Such a decoupled design is desirable, since it allows us to significantly re-use functionality and promotes overall system robustness. In conducting this exercise, we found that TinyDB influenced the re-design of Diffusion in several important ways. 1
Evaluation of scatter effects in phoswich detector modules of a dedicated small animal PET scanner (2009)

1501 Objectives The goal is to evaluate the effect of photon scatter within the phoswich detectors, or detector scatter (DS), on resolution and quantitative accuracy of a commercial small animal PET scanner using Monte Carlo (MC) simulation. Methods The phoswich detector consists of 7mm thick LYSO and 8mm thick GSO scintillators. Line-of-response data were MC simulated from a point source placed in 4mm increments along the central axis and in 5mm increments along a transaxial radius. Both 250-700keV and 400-700keV energy windows (EW) with and without DS were modeled, and DS with and without depth-of-interaction (DOI) correction were compared. System resolution, in terms of FWHM, was determined from the 2D OS-EM reconstructed image of the point source. Recovery coefficients (RC) from 3D regions-of-interest (ROI) with different diameters were calculated. Results The radial, tangential and axial resolution obtained with 250-700keV EW showed differences of 7%, 7% and 4%, respectively, between that with and without DS when averaged over different axial locations; and 10%, 7% and 2% when averaged over the radial locations. The RC for point sources along the central axis reached 95% at 12.0mm and 9.2mm ROI diameters for 250-700keV and 400-700keV EW with DS, and at 2.5mm for both EW without DS. The RC for point sources modeled with and without DOI correction differed by 6mm. Conclusions DS has larger effect on the radial and tangential than the axial resolution for a small animal PET scanner with phoswich detectors. It has significant effect on the PET quantitation due to the long tail of point response function. The effect of DS can be reduced with a narrower EW at the expense of lower counts. DOI correction has small effect in reducing DS. Research Support This work was funded in parts by NIH grant CA92781 and EB1558.
Concurrent hydrogen migration and nitrogen extrusion in the excited states of alkylchlorodiazirines (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConcurrent hydrogen migration and nitrogen extrusion in the excited states of alkylchlorodiazirinesWalter R. White III and Matthew S. PlatzCite this: J. Org. Chem. 1992, 57, 10, 2841–2846Publication Date (Print):May 1, 1992Publication History Published online1 May 2002Published inissue 1 May 1992https://pubs.acs.org/doi/10.1021/jo00036a016https://doi.org/10.1021/jo00036a016research-articleACS PublicationsRequest reuse permissionsArticle Views148Altmetric-Citations62LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Single‐Walled Carbon Nanotubes: Tuning Geometry of SWCNTs by CO2 in Floating Catalyst CVD for High‐Performance Transparent Conductive Films (Adv. Mater. Interfaces 23/2018) (2018)

In floating catalyst chemical vapor deposition for single-walled carbon nanotube (SWCNT) growth, employing certain amount of CO2 can obtain SWCNTs with larger diameter, longer length and smaller bundle diameter. The corresponding SWCNT transparent thin films display excellent conductivity due to the optimized geometry. More details can be found in the article number 1801209 by Yongping Liao, Qiang Zhang, Esko I. Kauppinen, and co-workers.
Ocular iontophoresis of EGP-437 (dexamethasone phosphate) in dry eye patients: results of a randomized clinical trial (2011)

Ocular iontophoresis of EGP-437 demonstrated statistically and clinically significant improvements in signs and symptoms of dry eye syndrome within a CAE model.
Reservoir Architecture Characterization From Integration of Fluid Property Distributions With Other Logs (2009)

Abstract Characterizing reservoir architecture and fluid property distributions at the early exploration and appraisal stage are critical for reservoir assessment, planning and management. Particularly for thinly laminated reservoirs, identification of hydrocarbon-bearing zones and determination of the flow unit sizes have profound impact on long term production predictions. In this paper, a case study is presented that integration of reservoir fluid property distribution with other logs leads to accurate reservoir understanding. In this method, downhole fluid analysis (DFA) is used to identify key production parameters of reservoir fluids in real time and at downhole conditions. DFA results are combined with other logs to develop a view of reservoir architecture especially pinpointing thin pay zones with low resistivity, which could be treated as wet by open-hole logs. Indeed, 19 DFA stations were performed in this particular well and represents a typical number of DFA stations per well in this field (another well in this field had significantly more DFA stations that established a world record). The results of the improved interpretation are confirmed by subsequent well test data. The case study indicates that the methodology of integrating DFA with other logs provides a powerful and cost effective approach for reservoir understanding and assessment at the exploration stage, which is invaluable for optimal reservoir management and development planning.
Soluble sugars in maturing pea seeds of different lines in relation to desiccation tolerance. (2009)

The relationship between the accumulation of soluble non-reducing sugars and the acquisition of desiccation tolerance during maturation of four pea lines differing in the content and composition of soluble carbohydrates was analysed. Maturing seeds were harvested at 4-day intervals, tested for desiccation tolerance (measured as the ability to germinate after slow and fast drying) and the soluble carbohydrates in axis and cotyledons were assayed. Immature seeds of RR RbRb and SD9 lines containing the lowest levels of raffinose were more sensitive to rapid drying as compared with seeds of other lines, but finally reached maximum desiccation tolerance at full maturity. Acquisition of desiccation tolerance was preceded by accumulation of sucrose and its development was accompanied by the accumulation of raffinose family oligosaccharides. Seeds of SD1 and SD6 lines did not accumulate verbascose, but this had no effect on their desiccation tolerance.
Coherence-based near-oracle performance guarantees for sparse estimation under Gaussian noise (2010)

We consider the problem of estimating a deterministic sparse vector x <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> from underdetermined measurements Ax <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> + w, where w represents white Gaussian noise and A is a given deterministic dictionary. We analyze the performance of three sparse estimation algorithms: basis pursuit denoising, orthogonal matching pursuit, and thresholding. These approaches are shown to achieve near-oracle performance with high probability, assuming that x <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> is sufficiently sparse. Our results are non-asymptotic and are based only on the coherence of A, so that they are applicable to arbitrary dictionaries.