gebhart/patrepeval huggingface dataset:
Bilin attachment sites in the alpha and beta subunits of B-phycoerythrin. Structural studies on the singly linked phycoerythrobilins. (1984)

Five unique phycoerythrobilin (PEB) peptides were prepared from Porphyridium cruentum B-phycoerythrin by a combination of tryptic and thermolytic digestion without alteration in the spectroscopic properties of the bilin (Lundell, D.J., Glazer, A.N., DeLange, R.J., and Brown, D.M. (1984) J. Biol. Chem. 259, 5472-5480). alpha-1 Cys(PEB)-Tyr-Arg alpha-2 Leu-Cys(PEB)-Val-Pro-Arg beta-1 Met-Ala-Ala-Cys(PEB)-Leu-Arg beta-2T Phe-Ala-Ala-Gly-Asp-Cys(PEB)-Thr-Ser (Formula: see text) where alpha and beta refer to the subunits from which the peptides were derived High resolution 1H NMR analysis of peptides alpha-2, beta-1, and beta-2T combined with earlier studies of peptide alpha-1 (Schoenleber, R.W., Leung, S.-L., Lundell, D.J., Glazer, A.N., and Rapoport, H. (1983) J. Am. Chem. Soc. 105, 4072-4076) has provided proof that all of the singly linked PEB peptides contain a thioether bond to the 3' position of ring A, and strong evidence in support of a trans-dihydro ring A in each of these chromopeptides. The circular dichroism spectra of the four singly linked PEB peptides show that the configuration at C-16 is R in each instance. The present study coupled with previously reported results on peptide beta-3T (Schoenleber, R.W., Lundell, D.J., Glazer, A.N., Rapoport, H. (1984) J. Biol. Chem. 259, 5481-5484 provides the first comprehensive analysis of the structure of all the polypeptide-linked prosthetic groups on the alpha and beta subunits of B-phycoerythrin.
Bulk-plasmon-mediated free-electron radiation beyond the conventional formation time (2022)

Free-electron radiation is a fundamental photon emission process that is induced by fast-moving electrons interacting with optical media. Historically, it has been understood that, just like any other photon emission process, free-electron radiation must be constrained within a finite time interval known as the "formation time", whose concept is applicable to both Cherenkov radiation and transition radiation, the two basic mechanisms describing radiation from a bulk medium and from an interface, respectively. Here we reveal an alternative mechanism of free-electron radiation far beyond the previously defined formation time. It occurs when a fast electron crosses the interface between vacuum and a plasmonic medium supporting bulk plasmons. While emitted continuously from the crossing point on the interface - thus consistent with the features of transition radiation - the extra radiation beyond the conventional formation time is supported by a long tail of bulk plasmons following the electron's trajectory deep into the plasmonic medium. Such a plasmonic tail mixes surface and bulk effects, and provides a sustained channel for electron-interface interaction. These results also settle the historical debate in Ferrell radiation, regarding whether it is a surface or bulk effect, from transition radiation or plasmonic oscillation.
Network dynamics of the brain and influence of the epileptic seizure onset zone (2014)

The human brain is a dynamic networked system. Patients with partial epileptic seizures have focal regions that periodically diverge from normal brain network dynamics during seizures. We studied the evolution of brain connectivity before, during, and after seizures with graph-theoretic techniques on continuous electrocorticographic (ECoG) recordings (5.4 ± 1.7 d per patient, mean ± SD) from 12 patients with temporal, occipital, or frontal lobe partial onset seizures. Each electrode was considered a node in a graph, and edges between pairs of nodes were weighted by their coherence within a frequency band. The leading eigenvector of the connectivity matrix, which captures network structure, was tracked over time and clustered to uncover a finite set of brain network states. Across patients, we found that (i) the network connectivity is structured and defines a finite set of brain states, (ii) seizures are characterized by a consistent sequence of states, (iii) a subset of nodes is isolated from the network at seizure onset and becomes more connected with the network toward seizure termination, and (iv) the isolated nodes may identify the seizure onset zone with high specificity and sensitivity. To localize a seizure, clinicians visually inspect seizures recorded from multiple intracranial electrode contacts, a time-consuming process that may not always result in definitive localization. We show that network metrics computed from all ECoG channels capture the dynamics of the seizure onset zone as it diverges from normal overall network structure. This suggests that a state space model can be used to help localize the seizure onset zone in ECoG recordings.
High performance germanium N+∕P and P+∕N junction diodes formed at low Temperature (⩽380°C) using metal-induced dopant activation (2008)

We demonstrate high performance Ge N+∕P and P+∕N junction diodes at sub-380°C. Very low resistivity (2.2×10−4Ωcm) and shallow (92nm) junction with high degree of dopant activation are achieved especially in N+∕P junction formed at 360°C on Ge epitaxially grown on Si using complementary metal-oxide semiconductor process compatible-metal (Co) induced dopant activation technique. Excellent diode characteristics having ∼2×104 on/off ratio and high forward current density (221A∕cm2 for N+∕P and 135A∕cm2 for P+∕N at ∣VF∣=2V) are obtained in N+∕P and P+∕N junction diodes fabricated at 380°C on bulk Ge with a surface passivated layer [GeO2+low temperature chemical vopor deposition SiO2 (LTO)] isolation.
Synthesis and antiplatelet effects of an isoxazole series of glycoprotein IIb/IIIa antagonists (1998)

Despite the excellent in vitro potency of a series of benzamide glycoprotein IIb/IIIa antagonists, which have been reported previously, poor in vivo potency in the inhibition of platelet aggregation was observed when the most potent inhibitor XU057 was dosed intravenously to dogs. In this communication, we report that replacement of the benzamide in XU057 with an isoxazolecarboxamide resulted in significant improvement in in vivo potency. More importantly, the analogue XU065 showed an excellent oral antiplatelet effect in dogs.
fMRI retinotopy in strabismic amblyopia without rotating wedges (2004)

Retinotopy is the mapping of location in the visual field onto the cortical surface of the brain. The borders between early visual areas can be identified by retinotopy, since they occur at the foci of symmetry reversals in the polar angle plot. Amblyopia is a condition of monocular visual impairment, caused by an early mismatch between the two eyes' images, as with strabismus. It is thought to involve the active suppression of one eye's cortical representation during development. Although physiological abnormalities in primary visual cortex (V1) have been studied extensively in animal models of amblyopia, as well as post-mortem studies, less is known about the role of extra-striate visual areas. Of particular interest is the development of areas believed to sustain normal binocular vision, such as V3 and V3a. However, these areas can be hard to identify using conventional rotating-wedge stimuli for retinotopy, as strabismic amblyopes often have difficulty maintaining central fixation. We have developed stimuli that flash on and off at different times, in different parts of the visual field, following independent timeseries. Our data show that, using the anatomical segmentation of the two hemispheres as an objective reference, rotating wedges gave particularly poor retinotopy in amblyopic eyes. In contrast, few (<5%) of the visuotopic voxels were mis-assigned with our stimuli, regardless of the eye-of-origin. Using these stimuli, we hope to identify extra-striate monocular abnormalities in amblyopia.
Supplementary Figure S1 from Tumor-Associated Hyaluronan Limits Efficacy of Monoclonal Antibody Therapy (2023)

&lt;p&gt;Human HAS2 gene overexpression increases HA secretion.&lt;/p&gt;
Guidelines For Selecting Or Synthesizing Nematic Liquid Crystals (1986)

Principles for selecting or synthesizing liquid crystal mixtures with desired birefringence are analyzed. Based on these principles a liquid crystal mixture exhibiting large birefringence and low visco-elastic coefficient at room temperature was formulated. Optical and electro-optic properties of this liquid crystal were characterized at elevated temperature. Results are compared with those of some commercially available liquid crystals.
AMBROSia: An Overview and Recent Results (2011)

Observing systems facilitate scientific studies by instrumenting the real world and collecting corresponding measurements, with the aim of detecting and tracking phenomena of interest. A wide range of critical environmental monitoring objectives in resource management, environmental protection, and public health all require distributed observing systems. The goal of such systems is to help scientists verify or falsify hypotheses with useful samples taken by the stationary and mobile units, as well as to analyze data autonomously to discover interesting trends or alarming conditions. In our AMBROSia project, we focus on a class of observing systems which are embedded into the environment, consist of stationary and mobile sensors, and react to collected observations by reconfiguring the system and adapting which observations are collected next. In this paper, we give an overview of AMBROSia.
Carbon Nanotube/Conductive Additive/Space Durable Polymer Nanocomposite Films for Electrostatic Charge Dissipation (2003)

Thin film membranes of space environmentally stable polymeric materials possessing low color/solar absorptivity (alpha) are of interest for potential applications on Gossamer spacecraft. In addition to these properties, sufficient electrical conductivity is required in order to dissipate electrostatic charge (ESC) build-up brought about by the charged orbital environment. One approach to achieve sufficient electrical conductivity for ESC mitigation is the incorporation of single wall carbon nanotubes (SWNTs). However, when the SWNTs are dispersed throughout the polymer matrix, the nanocomposite films tend to be significantly darker than the pristine material resulting in a higher alpha. The incorporation of conductive additives in combination with a decreased loading level of SWNTs is one approach for improving alpha while retaining conductivity. Taken individually, the low loading level of conductive additives and SWNTs is insufficient in achieving the percolation level necessary for electrical conductivity. When added simultaneously to the film, conductivity is achieved through a synergistic effect. The chemistry, physical, and mechanical properties of the nanocomposite films will be presented.
Planning in child and family psychiatry (1983)

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An enhanced PWM method for loss balancing of five level T-type inverter in PV systems (2018)

Multilevel inverters have attracted much industry and research concerns in photovoltaic (PV) applications. Although, it is demonstrated that power switching devices are subjected to unequal distribution of power losses and the reliability of multilevel inverters becomes low in accordance. Therefore, a new pulse width modulation (PWM) method is proposed in this paper for loss balancing in single phase five level inverters. The proposed method swaps the utilization of power components through the line period using the redundancy property between the switching states of T-type multilevel inverters. In addition, natural balance of voltages over DC link capacitors is achieved using the proposed method. The superiority of the proposed method is verified using simulation and experimental prototypes.
Operating in sub-arc seconds: high-precision laser terminals for intersatellite communications (2002)

The paper presents the general interplay of coarse and fine tracking sub systems for an optical intersatellite link terminal. It briefly describes the hardware items that were designed by the Contraves Space led team to realise the required pointing, acquisition and tracking (PAT) functionality, especially in view of a commercial use of the terminals. Additionally, the control concept is outlined and test results are presented that were obtained during PAT sub system tests, used to verify the acquisition algorithms and the closed loop tracking performance.
The DESERVE project: Towards future ADAS functions (2014)

This article introduces the objectives and structure of the European research project DESERVE that is co-funded by the ARTEMIS-JU and national funding bodies. The project started in September 2012 with a duration of 3 years. The project aims to establish a new embedded SW and HW design by using a more efficient development process (including the enabling general platform concept and tool chain) in order to overcome challenges in reducing component costs and development time of future ADAS functions for modern vehicles. Both the process and the platform concept will be demonstrated with innovative ADAS functions in 3 passenger cars, 1 truck and 1 motorcycle. Embedded hardware and software units have been developed for improving electronic horizon band of vehicles by detecting objects in front. Moreover, driver/motorcycle rider awareness is analysed by monitoring his/her actions online. The systems need to be robust and reliable in different environment conditions (night time, rain, etc.). The DESERVE platform distinguishes three layers of intelligence: perception, application and intervention&warning control. The demonstrators will be based on software development tools from Elektrobit (ADTF) and Intempora (RTmaps). These tools are used to create 10 innovative ADAS applications as part of an integral ADAS development platform, following a new design and development process. Since the project is highly application oriented, the requirements have been adapted mainly from the ISO 26262 standard and the AUTOSAR framework which ensures compatibility with the existing automotive software environment.
Neutrophil Activation and Immune Thrombosis Profiles Persist in Convalescent COVID-19 (2023)

The lack of restoration of gene expression to a normal profile after up to 6 months of follow-up, even in asymptomatic patients who experienced severe COVID-19, signals the need to carefully extend their clinical follow-up and propose preventive measures.
Brick manufacture with fly ash from Illinois coals. Quarterly technical report, September 1, 1994--November 30, 1994 (1995)

This investigation seeks to utilize fly ash in fired-clay products such as building and patio bricks, ceramic blocks, field and sewer tile, and flower pots. This goal is accomplished by (1) one or more plant-scale, 5000-brick tests with fly ash mixed with brick clays at the 20% or higher level; (2) a laboratory-scale study to measure the firing reactions of a range of compositions of clay and fly ash mixtures; (3) a technical and economic study to evaluate the potential environmental and economic benefits of brick manufacture with fly ash. Bricks and feed materials will be tested for compliance with market specifications and for leachability of pollutants derived from fly ash. The laboratory study will combine ISGS databases, ICCI-supported characterization methods, and published information to improve predictions of the firing characteristics of Illinois fly ash and brick clay mixtures. Because identical methods are used to test clay firing and coal ash fusion, and because melting mechanisms are the same, improved coal ash fusion predictions are an expected result of this research. If successful, this project should convert an environmental problem (fly ash) into valuable products - bricks. During this quarter, the authors set up the manufacturing run at Colonial Brick Co., provided an expanded NEPA questionnaire for DOE, made preliminary arrangements for a larger brick manufacturing run at Marseilles Brick Co., revised laboratory procedures for selective dissolution analysis, and began characterization of brick clays that could be mixed with fly ash for fired-clay products.
Identification of Freezing of Gait in Parkinson’s Patients Using Instrumented Shoes and Artificial Neural Networks (2020)

Freezing of gait is an episodic phenomena faced by many patients with Parkinson's disease. It is characterized by episodes during which patients are unable to generate effective forward stepping movements, despite absence of motor deficits. It has been postulated that the degree of freezing can be reduced by providing external sensory feedback to the patients during the event. However, this intervention could be facilitated by accurate identification of freezing events in real-time. This manuscript presents an Artificial Neural Network model which uses signals recorded by an instrumented footwear to predict if a walking subject is having a freezing episode. Our model presented in this paper is capable of continuously predicting freezing of gait events at a high temporal resolution of 50 Hz, using a 0.5 second window of data recorded by the instrumented shoes, with a sensitivity of 96.0±2.5%, a specificity of 99.6±0.3%, a precision of 89.5±5.9%, and an accuracy of 99.5±0.4%. This algorithm was tested with data collected from 10 patients with Parkinson's disease with frequent freezing of gait episodes.
Immunoscintigraphy of Pneumocystis carinii pneumonia in AIDS patients. (1994)

Our findings suggest that PCP can be diagnosed by a noninvasive imaging method employing a small dose of a 99mTc-labeled Mab showing specificity for the infectious organism, since patients with P. carinii-free pneumonia were correctly negative in 87.5% of cases. Rapid diagnosis and organ-localization of other infectious lesions with organism-specific, radiolabeled Mabs may be feasible.
Design Principle for Low Bending Losses in All-Solid Photonic Bandgap Fibers (2010)

The structural dependence of factors which mainly affect a bending loss property is theoretically investigated in all-solid photonic bandgap fibers. A design principle for realizing a low bending loss is successfully figured out.
Generation of permanent optically induced second-order nonlinearities in optical fibers by poling (1988)

It is shown that large permanent enhancements in second-order optical nonlinearity can be induced in germanosilicate fibers (both pure and codoped with phosphorus) by application of a transverse dc electric poling field in the presence of high-intensity light. The macroscopic inversion symmetry of the core material is broken by the excitation and alignment of defect centers. Significant frequency doubling results despite the absence of phase matching. The saturation (with both increasing dc field and increasing intensity) of this effect is investigated.
Abstract 4207: JAK inhibition reverses IL10-mediated resistance to B cell receptor (BCR) pathway inhibition in DLBCL (2014)

Abstract Diffuse large B cell lymphoma (DLBCL) is the most common form of non-Hodgkin's lymphoma, and can be classified into activated B-cell like (ABC) and germinal center B-cell like (GCB) DLBCL according to gene expression profiling. In both subtypes, dysregulation of the B cell receptor (BCR) signaling pathway plays a critical role in tumorigenesis and survival. BCR activation induces phosphorylation of CD79A/B by Src family tyrosine kinases, which leads to the activation of the BTK and PI3Kδ/Akt pathways. Oncogenic mutations have been identified in DLBCL impacting CD79A/B (BCR complex), PTEN (negative regulator of PI3K), CARD11 and MYD88 (NF-kB activating factors) function. The influence of these mutations on the DLBCL phenotype appears to be further modified by aberrant cytokine signaling and JAK/Stat pathway activation. High levels of JAK/Stat-activating cytokines such as IL6 and IL10 are present in DLBCL, and patients with high serum IL10 have been shown to have shorter event-free survival and a higher international Prognostic Index score. Therefore, concurrent inhibition of both the BCR and JAK/Stat pathways may provide an attractive therapeutic approach in DLBCL. We have developed and characterized a potent and selective PI3Kδ inhibitor INCB040093 and have established that DLBCL cells are sensitive to INCB040093 treatment. We demonstrate that IL10 activates the JAK/Stat signaling pathway in DLBCL cells, which renders the cells resistant to INCB040093 in cell proliferation assays. This resistance can be reversed by co-treatment with a JAK1/JAK2 inhibitor. Although INCB040093 induces apoptosis in DLBCL cells, concurrent activation of the JAK/Stat pathway by IL10 prevents INCB040093-induced apoptosis, an effect that can be abrogated by a JAK1/JAK2 inhibitor. Similar resistance to IL-10 is observed with the BTK inhibitor, ibrutinib, which can also be reversed by a JAK1/JAK2 inhibitor. Interestingly, a JAK1 selective inhibitor is as effective as a JAK1/JAK2 inhibitor in reversing the IL10-mediated resistance to PI3Kδ and BTK inhibition. Combination treatment blocks both PI3K/Akt and JAK/Stat signaling pathways and results in the down-regulation of pro-survival proteins, including Pim2 and c-myc. These data illustrate the functional cross-talk that exists in DLBCL between the BCR and JAK/Stat signaling pathways, and support the clinical evaluation of combined BCR and JAK inhibition as a novel approach to targeted therapy. Citation Format: Xuesong (Mike) Liu, Margaret Favata, Jun Li, Niu Shin, Kathy He Wang, Qian Wang, Yun-Long Li, Andrew Combs, Chu-Biao Xue, Robert Newton, Kris Vaddi, Peggy Scherle. JAK inhibition reverses IL10-mediated resistance to B cell receptor (BCR) pathway inhibition in DLBCL. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4207. doi:10.1158/1538-7445.AM2014-4207
Preparation of amorphous magnetite nanoparticles embedded in polyvinyl alcohol using ultrasound radiation (2000)

Uniformly dispersed amorphous nanoparticles of magnetite in polyvinyl alcohol have been obtained by ultrasound radiation. The properties of the as-prepared composite material were characterized by various analytical methods. We have found that the magnetite particles that were 12–20 nm in diameter were very well dispersed in the PVA. The magnetization measurements establish that the composite material is superparamagnetic in nature.
Simultaneous dual-contrast three-dimensional imaging in live cells via optical diffraction tomography and fluorescence (2019)

We report a dual-contrast method of simultaneously measuring and visualizing the volumetric structural information in live biological samples in three-dimensional (3D) space. By introducing a direct way of deriving the 3D scattering potential of the object from the synthesized angular spectra, we obtain the quantitative subcellular morphology in refractive indices (RIs) side-by-side with its fluorescence signals. The additional contrast in RI complements the fluorescent signal, providing additional information of the targeted zones. The simultaneous dual-contrast 3D mechanism unveiled interesting information inaccessible with previous methods, as we demonstrated in the human immune cell (T cell) experiment. Further validation has been demonstrated using a Monte Carlo model. (C) 2019 Chinese Laser Press.