gebhart/patrepeval huggingface dataset:
Prediction and Measurement of the Vibration and Acoustic Radiation of Panels Subjected to Acoustic Loading (1995)

this paper were generated using a previously developed computational method. The panel was modeled using a finite element analysis
A phase 1/2 study of the oral proteasome inhibitor ixazomib in relapsed or refractory AL amyloidosis (2017)

This phase 1/2 study assessed the safety, tolerability, and preliminary efficacy of the oral proteasome inhibitor (PI) ixazomib in patients with relapsed/refractory immunoglobulin light chain (AL) amyloidosis. Ixazomib was administered to adult patients with relapsed/refractory AL amyloidosis after 1 or more prior lines of therapy (including bortezomib) on days 1, 8, and 15 of 28-day cycles, for up to 12 cycles. Patients with less than partial response after 3 cycles received oral dexamethasone (40 mg, days 1-4) from cycle 4. A 3+3 dose-escalation phase was followed by 2 expansion cohorts (PI-naive and PI-exposed patients) at the maximum tolerated dose (MTD). Twenty-seven patients were enrolled: 11 during dose escalation (6 at 4.0 mg and 5 at 5.5 mg) and 16 during dose expansion (4.0 mg). Three patients experienced dose-limiting toxicities: 1 at 4.0 mg and 2 at 5.5 mg; the MTD was determined as 4.0 mg. Most common adverse events (AEs) included nausea, skin and subcutaneous tissue disorders (SSTD), diarrhea, and fatigue; grade 3 or higher AEs included dyspnea, fatigue, and SSTD. Overall, the hematologic response rate was 52% in patients treated at the MTD (n = 21). Organ responses were seen in 56% of patients (5 cardiac, 5 renal). Median hematologic progression-free survival was 14.8 months; 1-year progression-free and overall survival rates were 60% and 85%, respectively (median follow-up, 16.9 months). Weekly oral ixazomib appears to be active in patients with relapsed/refractory AL amyloidosis, with a generally manageable safety profile. The study was registered at clinicaltrials.gov as #NCT01318902 A phase 3 study is ongoing (#NCT01659658).
ChemInform Abstract: Heteroatom‐Directed Metalation. Lithiation of N‐Propenylbenzamides and N‐Propenyl‐o‐toluamides. Novel Routes to Ortho‐Substituted Primary Benzamide Derivatives and N‐Unsubstituted Isoquinolin‐1(2H)‐ones. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
<title>Spectral-component monitoring and control of pulsed laser deposition of YBCO films</title> (1997)

We examine the time-resolved spectral components emitted at approximately 327 nm and approximately 550 nm in YBCO plumes during pulsed laser deposition of thin films using a KrF excimer laser at (lambda) equals 248 nm. The studied emission signals last for approximately 20 microsecond(s) ec, and show variations when process parameters such as laser power, laser excitation voltage, beam focus, chamber pressure, substrate temperature, pulse repetition rate, and target rotation rate are changed. These signals are also dependent on other factors such as target wear and age of the laser gas mixture. Spectral-component monitoring is a supplementary method of real-time plume evaluation, and allows observation of changes both prior to deposition and during the actual deposition. Adjustments can be made to the process parameters to make the plume conform to criteria necessary for the growth of films with specific qualities. The use of these spectral components as real-time process- control state variables for more reproducible fabrication of high quality thin films will be assessed.
From mating to foraging: the evolution of eavesdropping in frog-biting mosquitoes (2021)

&lt;p&gt;While the origins of communication signals have long fascinated evolutionary biologists, our understanding of how selective pressures across contexts shape sensory systems is still limited. Most mosquito and midge species use hearing during acoustic mating behaviors. For frog-biting species, however, hearing plays an important role beyond mating as females rely on anuran calls to obtain a blood meal. This dataset was used to directly test the hypothesis that hearing to exploit the communication system of frogs evolved, as a co-opted trait, from hearing conspecifics for mating. Behavioral, neurophysiological and biomechanical analyses revealed that the antenna of a unique frog-biting species can detect frog calls by relying on neural and mechanical responses comparable to those of non-frog-biting species.&amp;nbsp;&lt;/p&gt;
ChemInform Abstract: Synthesis and Platelet Activating Factor (PAF) Receptor Antagonist Activity of 2,5‐Diarylcyclopentanol Derivatives. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Effect of long-term corticosteroid treatment on microRNA and gene-expression profiles in COPD (2019)

The aim was to investigate whether microRNA (miRNA) expression is modulated by inhaled corticosteroid (ICS) treatmentWe performed genome-wide miRNA analysis on bronchial biopsies of 69 moderate/severe chronic obstructive pulmonary disease (COPD) patients at baseline and after 6- and 30-month treatment with the ICS fluticasone propionate or placebo. The effect of ICS on miRNA expression was validated in differentiated primary bronchial epithelial cultures, and functional studies were conducted in BEAS-2B cells. MiRNAs affected by ICS and their predicted targets were compared to an independent miRNA dataset of bronchial brushings from COPD patients and healthy controls.Treatment with ICS for both 6 and 30 months significantly altered the expression of four miRNAs, including miR-320d, which was increased during ICS treatment compared with placebo. The ICS-induced increase of miR-320d was confirmed in primary airway epithelial cells. MiR-320d negatively correlated targets were enriched for pro-inflammatory genes and were increased in the bronchial brushes of patients with lower lung function in the independent dataset. Overexpression of miR-320d in BEAS-2B cells dampened cigarette smoke extract-induced pro-inflammatory activity <i>via</i> inhibition of nuclear factor-κB.Collectively, we identified miR-320d as a novel mediator of ICS, regulating the pro-inflammatory response of the airway epithelium.
GaAs Nanowires Grown by Catalyst Epitaxy for High Performance Photovoltaics (2018)

Photovoltaics (PVs) based on nanostructured III/V semiconductors can potentially reduce the material usage and increase the light-to-electricity conversion efficiency, which are anticipated to make a significant impact on the next-generation solar cells. In particular, GaAs nanowire (NW) is one of the most promising III/V nanomaterials for PVs due to its ideal bandgap and excellent light absorption efficiency. In order to achieve large-scale practical PV applications, further controllability in the NW growth and device fabrication is still needed for the efficiency improvement. This article reviews the recent development in GaAs NW-based PVs with an emphasis on cost-effectively synthesis of GaAs NWs, device design and corresponding performance measurement. We first discuss the available manipulated growth methods of GaAs NWs, such as the catalytic vapor-liquid-solid (VLS) and vapor-solid-solid (VSS) epitaxial growth, followed by the catalyst-controlled engineering process, and typical crystal structure and orientation of resulted NWs. The structure-property relationships are also discussed for achieving the optimal PV performance. At the same time, important device issues are as well summarized, including the light absorption, tunnel junctions and contact configuration. Towards the end, we survey the reported performance data and make some remarks on the challenges for current nanostructured PVs. These results not only lay the ground to considerably achieve the higher efficiencies in GaAs NW-based PVs but also open up great opportunities for the future low-cost smart solar energy harvesting devices.
NON-RESONANT MICROWAVE ABSORPTION : A MICROPROBE TO SUPERCONDUCTIVITY IN Y1Ba2Cu3O7-δ (1988)

The superconducting transition onset temperature in YBaCuO monitored using the microwave absorption technique shows little change as a function of lattice distortion due to oxygen depletion indicating the presence of the orthorhombic superconducting phase even in highly oxygen-depleted samples.
Propensity Matched Analysis of Perioperative Outcomes in Robotic-Assisted Thoracic Surgery, Video Assisted Thoracic Surgery, and Open Lung Resections (2018)

Haro, Greg J. MD; Kratz, Johannes R. MD; Jablons, David M. MD; Mann, Michael J. MD; Kukreja, Jasleen MD Author Information
Structural Aspects of Thermally Cleavable Adducts Derived from the Reaction of Imidazolines with Isocyanates (2016)

The reaction of isocyanates with substituted imidazolines and the thermally induced cleavage of the resulting adducts are presented. For this purpose, reactions of various isocyanates [ethyl isocyanate, <i>p</i>-methylphenyl isocyanate, phenyl isocyanate, <i>p</i>-(trifluoromethyl)phenyl isocyanate] with 1-alkylimidazoline derivatives have been studied as a function of the substituent at the 2-position of the imidazoline ring. Three equivalents of isocyanate react with one equivalent of 1-ethylimidazoline to give a stoichiometric well-defined adduct. However, 1-ethyl-2-isopropylimidazoline reacts with isocyanates at 0 °C in another way, with formation of 2:1 adducts which belong to the family of 1,3-diphenyltetrahydroimidazo[1,2-<i>a</i>][1,3,5]triazine-2,4(1<i>H</i>,3<i>H</i>)-diones. The reaction of 1-ethyl-2-methylimidazoline with aromatic isocyanates at 0 °C also leads to 2:1 adducts, in this case of a malonamide type, which can react at 60 °C with an additional isocyanate equivalent to give the known pyrimidinediones. Thermal analysis (TG-MS/DSC) and trapping reactions with nucleophilic reagents, such as diphenylamine, show the release of isocyanate during the thermally induced cleavage reaction. Thus, blocked isocyanates are available by the reaction of isocyanates with 1-ethylimidazoline or 1-ethyl-2-isopropylimidazoline.
New drugs in the treatment of psoriasis (2000)

Psoriasis is one of the most common skin disorders affecting approximately 2% of the population; the disease is recurrent and can be very debilitating. The cause of psoriasis is unknown, although it appears to be an autoimmune disease with a genetic component to its aetiology. Past topical treatments such as emollients, coal tar and dithranol have been messy, cosmetically unacceptable or of low efficacy, while older systemic therapies have suffered from significant side effects. Newer drugs with better therapeutic indexes and new antiproliferative/immunomodulatory therapies based on an increased understanding of the origins of psoriasis have brought us closer to the goal of safely and efficaciously treating the disease. This review will cover the newest topical and systemic drugs currently in use, in clinical trials or preclinical development.
Operational stabilization of a high-power ultrashort dye oscillator–amplifiers laser chain (1994)

Stable operation of a high-power ultrashort dye laser chain is achieved with an inexpensive heating technique. The femtosecond oscillator and its pumping laser are separately covered with boxes to isolate them from external temperature fluctuations. Both laser-isolating boxes are lined with a heating pellicle that permanently and uniformly warms the lasers to preset operating temperatures. The power, spectrum, and duration of the laser-chain output pulse remain constant from day to day. This technique could be applied to other ultrafast laser devices that require long-term performance stability.
In Planta Effector Competition Assays DetectHyaloperonospora arabidopsidisEffectors That Contribute to Virulence and Localize to Different Plant Subcellular Compartments (2013)

The genome of the pathogenic oomycete Hyaloperonospora arabidopsidis is predicted to encode at least 134 high-confidence effectors (HaRxL) carrying the RxLR motif implicated in their translocation into plant cells. However, only four avirulence genes (ATR1, ATR13, ATR5, and ATR39) have been isolated. This indicates that identification of HaRxL effectors based on avirulence is low throughput. We aimed at rapidly identifying H. arabidopsidis effectors that contribute to virulence by developing methods to detect and quantify multiple candidates in bacterial mixed infections using either Illumina sequencing or capillary electrophoresis. In these assays, referred to here as in planta effector competition assays, we estimate the contribution to virulence of individual effectors by calculating the abundance of each HaRxL in the bacterial population recovered from leaves 3 days after inoculation relative to abundance in the initial mixed inoculum. We identified HaRxL that enhance Pseudomonas syringae pv. tomato DC3000 growth in some but not all Arabidopsis accessions. Further analysis showed that HaRxLL464, HaRxL75, HaRxL22, HaRxLL441, and HaRxL89 suppress pathogen-associated molecular pattern-triggered immunity (PTI) and localize to different subcellular compartments in Nicotiana benthamiana, providing evidence for a multilayered suppression of PTI by pathogenic oomycetes and molecular probes for the dissection of PTI.
Partial Charge Transfer Reaction (2016)

This document contains recommendations for terminology in mass spectrometry. Development of standard terms dates back to 1974 when the IUPAC Commission on Analytical Nomenclature issued recommendations on mass spectrometry terms and definitions. In 1978, the IUPAC Commission on Molecular Structure and Spectroscopy updated and extended the recommendations and made further recommendations regarding symbols, acronyms, and abbreviations. The IUPAC Physical Chemistry Division Commission on Molecular Structure and Spectroscopy's Subcommittee on Mass Spectroscopy revised the recommended terms in 1991 and appended terms relating to vacuum technology. Some additional terms related to tandem mass spectrometry were added in 1993 and accelerator mass spectrometry in 1994. Owing to the rapid expansion of the field in the intervening years, particularly in mass spectrometry of biomolecules, a further revision of the recommendations has become necessary. This document contains a comprehensive revision of mass spectrometry terminology that represents the current consensus of the mass spectrometry community.
The primary structure of troponin T and the interaction with tropomyosin (1975)

1. Eight peptides were separated from the CNBr digest of troponin T from rabbit white skeletal muscle and characterized. 2. By study of the amino acid sequence of the methionine-containing peptides isolated after chymotryptic and tryptic digestion and of the N- and C-terminals of the CNBr peptides, six of the latter were shown to be arranged in the sequence CNB1-CNB2-CNB5-CNB6-CNB8-CNB7. The other two peptides, CNB1' and CNB3, have been shown to be partial digestion products. 3. The CNBr peptides CNB1' and CNB2 contained a common sequence and were the only peptides in CNBr digests of troponin T that formed a complex with tropomyosin as judged by viscometric and electrophoretic studies. 4. It is concluded that tropomyosin interacts with the N-terminal half of the troponin T molecule approximately in the region lying between residues 70 and 160. 5. Electrophoretic evidence indicates that tropomyosin and troponin C interact with troponin T. 6. None of the major CNBr peptides of troponin T isolated formed a complex with troponin C on electrophoresis at pH 8.6.
Reliability of SiC MOSFET with Danfoss Bond Buffer Technology in Automotive Traction Power Modules (2019)

This paper describes reliability investigations in terms of power cycling tests for a new generation of top-side sintered or soldered 1200 V silicon carbide (SiC) MOSFETs for use in an advanced power module, designed for operation with 800 V bus voltage in electric vehicle drive trains. The MOSFETs were packaged with different bonding and joining technologies. A power module assembly technique using sintered SiC MOSFETs interconnected with a sintered copper (Cu) foil and attached Cu wires was compared with both soldered and silver sintered die bonding combined with bonded aluminum (Al) wires to evaluate the reliability of three different techniques. Compared to the Al wire bonded assemblies with lift-off or solder degradation as the type of failure, heavy Cu wires with Danfoss Bond Buffer(r) (DBB(r)) on SiC achieved a significant increase in power cycling capability compared to traditional soldered packaging techniques. A shift in failure mechanism away from the interconnect technologies and towards a chip top metallization degradation was detected.
Optical clock sensitive to variations of the fine-structure constant based on theHo14+ion (2015)

We study the ${\mathrm{Ho}}^{14+}$ ion as a candidate for an extremely accurate and stable optical atomic clock which is sensitive to the time variation of the fine-structure constant. We demonstrate that the proposed system has all the desired features including relatively strong optical electric-dipole and magnetic-dipole transitions which can be used for cooling and detection. Zero quadrupole moments for the relevant states in the clock transition allow interrogation of multiple ions to improve the clock stability.
Development of a Minimalistic Physiologically Based Pharmacokinetic (mPBPK) Model for the Preclinical Development of Spectinamide Antibiotics (2023)

Spectinamides 1599 and 1810 are lead spectinamide compounds currently under preclinical development to treat multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis. These compounds have previously been tested at various combinations of dose level, dosing frequency, and route of administration in mouse models of <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>) infection and in healthy animals. Physiologically based pharmacokinetic (PBPK) modeling allows the prediction of the pharmacokinetics of candidate drugs in organs/tissues of interest and extrapolation of their disposition across different species. Here, we have built, qualified, and refined a minimalistic PBPK model that can describe and predict the pharmacokinetics of spectinamides in various tissues, especially those relevant to <i>Mtb</i> infection. The model was expanded and qualified for multiple dose levels, dosing regimens, routes of administration, and various species. The model predictions in mice (healthy and infected) and rats were in reasonable agreement with experimental data, and all predicted AUCs in plasma and tissues met the two-fold acceptance criteria relative to observations. To further explore the distribution of spectinamide 1599 within granuloma substructures as encountered in tuberculosis, we utilized the Simcyp granuloma model combined with model predictions in our PBPK model. Simulation results suggest substantial exposure in all lesion substructures, with particularly high exposure in the rim area and macrophages. The developed model may be leveraged as an effective tool in identifying optimal dose levels and dosing regimens of spectinamides for further preclinical and clinical development.
IMPEDANCE ANALYSIS FOR CHARACTERIZATION OF MATERIALS USED IN ORGANIC TRANSISTORS (2006)

A method of impedance frequency response analysis (FRA) with template multilayer organic capacitor was studied to evaluate printable materials for all-printed organic field-effect transistors (OFETs). The new method allows us not only to characterize simultaneously dielectric and conductive behaviors of the materials but also to distinguish contributions to electrical conduction or to polarization from different sources such as dielectric layer, semiconductor layer, and different interfaces for OFETs. As a dielectric layer for OFETs, Urathan is preferred because of lower conductivity, nonmetallic conduction behavior at high temperature, and lower interfacial resistance. Conductivity and dielectric enhancement of Urathan can be realized by heating. The critical temperature for conductivity and dielectricity transition was calculated from FRA from temperature dependent experiments. The method could be a standard for fast screening and assessing printable materials for OFETs.
Model Electrode Structures for Studies of Electrocatalyst Degradation (2010)

Model Pt catalyst structures have been fabricated directly on planar glassy carbon electrodes by physical vapor deposition. Application of these model electrodes toward the understanding of fuel cell catalyst degradation is demonstrated. These model electrodes are further improved with the development of a templated synthesis process to create Pt nanoparticle arrays of controlled size and spacing. The catalysts are characterized by scanning electron microscopy and rotating disk electrode experiments. Surface area loss from potential cycling is demonstrated with mechanisms of sintering, dissolution and particle detachment.
Knockdown of the cytoprotective chaperone, clusterin, chemosensitizes human breast cancer cells bothin vitroandin vivo (2005)

Clusterin is a stress-associated cytoprotective chaperone up-regulated by various apoptotic triggers in many cancers and confers treatment resistance when overexpressed. The objectives of this study were to evaluate clusterin expression levels in human breast cancer and to determine whether antisense oligonucleotides or double-stranded small interfering RNAs (siRNA) targeting the clusterin gene enhance apoptosis induced by paclitaxel. Clusterin immunostaining was evaluated in a tissue microarray of 379 spotted breast cancers. The effect of hormone withdrawal, paclitaxel treatment, clusterin antisense oligonucleotide (OGX-011), and siRNA treatments on clusterin expression was examined in MCF-7 and MDA-MB-231 cells. Northern, quantitative real-time PCR, and Western analyses were used to measure change in clusterin mRNA and protein levels. The effect of OGX-011 or siRNA clusterin treatment on chemosensitivity to paclitaxel was done in both cell lines in vitro, whereas the ability of OGX-011 to chemosensitize in vivo was evaluated in athymic mice bearing MCF-7 tumors. Clusterin was expressed in 62.5% of tumors within the tissue microarray. Clusterin expression increased after estrogen withdrawal and paclitaxel treatment in vitro in MCF-7 cells. OGX-011 or siRNA clusterin decreased clusterin levels by >90% in a dose-dependent, sequence-specific manner and significantly enhanced chemosensitivity to paclitaxel in vitro. When combined, OGX-011 or siRNA clusterin reduced the IC50 by 2-log compared with paclitaxel alone. In vivo administration of OGX-011 enhanced the effects of paclitaxel to significantly delay MCF-7 tumor growth. These data identify clusterin as a valid therapeutic target and provides preclinical proof-of-principle to test OGX-011 in multimodality therapies for breast cancer.