gebhart/patrepeval huggingface dataset:
Association of precipitating anti-adrenal anti-adrenal antibodies with moniliasis-polyendocrinopathy syndrome. (1976)

The association of precipitating anti-adrenal antibodies with different subgroups of idiopathic Addison's disease were studied. We had previously found these antibodies in patients with the moniliasis-polyendocrinopathy syndrome. Sera of 36 adult patients suffering from different froms of Addison's disease were examined for the presence of adrenal antibodies demonstrable either by immunofluorescence (IFL) or by gel diffusion. 3 of the 17 patients with tuberculous and 17 of 19 patients with idiopathic Addison's disease had IFL antibodies but only one had precipitating antibodies. There was one typical case of Schmidt's syndrome, and four additional cases with Addison's disease combined with diabetes or thyroiditis, who may later develop the syndrome. None of htese patients had precipitating anti-adrenal antibodies. The only patients with precipitating adrenal antibodies had the moniliasis-polyendocrinopathy syndrome. He was not typical as Addison' disease appeared unusually late and he did not have hypoparathyroidism. The presence of precipitating anti-adrenal antibodies in this patient, and the absence of these in other groups of Addison's disease, is further evidence for the association of precipitating antibodies with the moniliasis-polyendocrinopathy syndrome.
On making the current military radios cognitive without hardware or firmware modifications (2010)

Cognitive Radio (CR) using Dynamic Spectrum Access (DSA) provides the military radios, an ability to operate in un-predictable interference environments. CRs are capable of sensing their environment and autonomously changing the radio parameters such as frequency, bandwidth and power, to avoid interference. Large amount of resources have been invested by the Department of Defense (DoD) on building these radio systems which are currently not DSA enabled. This paper provides a way to make current military radios DSA capable without making any hardware or firmware modifications to them. Radios are made DSA capable by using an external sensor as compared to an embedded sensor containing advanced feature based sensing algorithms, application level messaging and a cognitive engine, which is written in a high level language that resides outside the radios. A real-time over-the-air demonstration for such a cognitive radio test-bed using a network of three Warfighter Information Network - Tactical (WIN-T) Local Area Waveform (LAW) nodes in friendly and un-friendly interference was carried out at the Ft. Dix facility of US Army CERDEC. This paper provides a brief overview of the system, operation of this test-bed and some field demonstration results.
DeCorus: Hierarchical Multivariate Anomaly Detection at Cloud-Scale (2022)

Multivariate anomaly detection can be used to identify outages within large volumes of telemetry data for computing systems. However, developing an efficient anomaly detector that can provide users with relevant information is a challenging problem. We introduce our approach to hierarchical multivariate anomaly detection called DeCorus, a statistical multivariate anomaly detector which achieves linear complexity. It extends standard statistical techniques to improve their ability to find relevant anomalies within noisy signals and makes use of types of domain knowledge that system operators commonly possess to compute system-level anomaly scores. We describe the implementation of DeCorus an online log anomaly detection tool for network device syslog messages deployed at a cloud service provider. We use real-world data sets that consist of $1.5$ billion network device syslog messages and hundreds of incident tickets to characterize the performance of DeCorus and compare its ability to detect incidents with five alternative anomaly detectors. While DeCorus outperforms the other anomaly detectors, all of them are challenged by our data set. We share how DeCorus provides value in the field and how we plan to improve its incident detection accuracy.
Optimal Individualized Treatments in Resource-Limited Settings (2016)

An individualized treatment rule (ITR) is a treatment rule which assigns treatments to individuals based on (a subset of) their measured covariates. An optimal ITR is the ITR which maximizes the population mean outcome. Previous works in this area have assumed that treatment is an unlimited resource so that the entire population can be treated if this strategy maximizes the population mean outcome. We consider optimal ITRs in settings where the treatment resource is limited so that there is a maximum proportion of the population which can be treated. We give a general closed-form expression for an optimal stochastic ITR in this resource-limited setting, and a closed-form expression for the optimal deterministic ITR under an additional assumption. We also present an estimator of the mean outcome under the optimal stochastic ITR in a large semiparametric model that at most places restrictions on the probability of treatment assignment given covariates. We give conditions under which our estimator is efficient among all regular and asymptotically linear estimators. All of our results are supported by simulations.
Post challenge inhibition of C3 and CD14 attenuates Escherichia coli-induced inflammation in human whole blood (2013)

Combined inhibition of CD14 and complement, two main inducers of the inflammatory response, have proved particularly effective in attenuating Gram-negative bacteria-induced inflammation. Approaching possible clinical relevance, we investigated the effect of such inhibition in a post-challenge setting. Human whole blood was anti-coagulated with lepirudin. Anti-CD14, compstatin (C3 inhibitor) and the combination thereof were added 5 min prior to or 5, 15 or 30 min after adding Escherichia coli. Total incubation time with Escherichia coli was 120 min. Cytokines, myeloperoxidase (MPO) and the terminal complement complex (TCC) were measured using multiplex technology and ELISA. Delayed combined inhibition significantly attenuated the inflammatory response. IL-1β, IL-8 and TNF-α were significantly inhibited in the range of 20-40%, even when adding the inhibitors with up to 30 min delay. IL-6 was significantly inhibited with 15 min delay, and MIP-1α and MPO with 5 min delay. Complement activation (TCC) was blocked completely at each time point compstatin was added, whereas the cytokines and MPO increased steadily between the time points. The combined regimen was significantly more effective than single inhibition in the pre-challenge setting. The attenuation of Escherichia coli-induced inflammation in a post-challenge setting suggests a potential therapeutic window for this treatment in sepsis.
Operando Direct Observation of Filament Formation in Resistive Switching Devices Enabled by a Topological Transformation Molecule (2021)

Conductive filaments (CFs) play a critical role in the mechanism of resistive random-access memory (ReRAM) devices. However, in situ detection and visualization of the precise location of CFs are still key challenges. We demonstrate for the first time the use of a π-conjugated molecule which can transform between its twisted and planar states upon localized Joule heating generated within filament regions, thus reflecting the locations of the underlying CFs. Customized patterns of CFs were induced and observed by the π-conjugated molecule layer, which confirmed the hypothesis. Additionally, statistical studies on filaments distribution were conducted to study the effect of device sizes and bottom electrode heights, which serves to enhance the understanding of switching behavior and their variability at device level. Therefore, this approach has great potential in aiding the development of ReRAM technology.
No bias pi cell using a dual alignment layer with an intermediate pretilt angle (2007)

The authors fabricated a no-bias pi cell using a dual alignment layer with an intermediate pretilt angle via a rubbing. In the dual alignment layer system, the competition between crest region favoring the vertical alignment and trough region favoring planar alignment made it possible to achieve various pretilt angles, and adjusted pretilt angle from 90° to 20° with rubbing. In addition, as the intermediate pretilt angle plays a role in eliminating the activation energy and thus allowing formation of the initial bend state in pi cell fabrication, this approach achieved a no-bias pi cell for a liquid crystal display with both low power consumption and fast response.
AN ALGEBRAIC APPROACH TO THE KOLMOGOROV-SINAI ENTROPY (1996)

We revisit the notion of Kolmogorov-Sinai entropy for classical dynamical systems in terms of an algebraic formalism. This is the starting point for defining the entropy for general non-commutative systems. Hereby typical quantum tools are introduced in the statistical description of classical dynamical systems. We illustrate the power of these techniques by providing a simple, self-contained proof of the entropy formula for general automorphisms of n-dimensional tori.
Benefits of Modularity in an Automated Essay Scoring System (2000)

E-rater is an operational automated essay scoring application that combines several NLP tools for the purpose of identifying linguistic features in essay responses to assess the quality of the text. The application currently identifies a variety of syntactic, discourse, and topical analysis features. We have maintained two clear visions of e-rater&amp;apos;s development. First, new linguistically-based features would be added to strengthen connections between human scoring guide criteria and e-rater scores. Secondly, e-rater would be adapted to automatically provide explanatory feedback about writing quality. This paper provides two examples of the flexibility of e-rater&amp;apos;s modular architecture for continued application development toward these goals. Specifically, we discuss a) how additional features from rhetorical parse trees were integrated into erater, and b) how the salience of automatically generated discourse-based essay summaries was evaluated for use as instructional feedback through ...
Heterogeneous Nucleation Characteristics of a Eutectic-Forming Vapor Mixture on a Cold Substrate (1994)

Abstract The formation of solid condensates by heterogeneous nucleation from a mixture of p-xylene and water vapor onto a cold substrate was observed by slowly cooling the substrate under reduced pressure conditions. The results from binary experiments were compared to those for the pure vapors. Two critical substrate temperatures, corresponding to the onset of nucleation, were determined experimentally at a given initial vapor pressure by observing a rapid decrease in the vapor pressure. A mixed vapor with a water content greater than 85% formed ice at the first critical point, and the critical partial vapor pressure agreed well with that for pure water. For mixed vapors in which the p-xylene content was greater than 30%, p-xylene crystals formed at the first critical point, but the critical vapor pressure tended to decrease with decreasing p-xylene content. For mixed vapors with a composition close to the eutectic, it was unclear which crystal formed at the first critical point. The relationship between the logarithm of the critical vapor pressure and the inverse of the critical temperature at the second critical point showed good linearity and was close to that at the eutectic condition. Using these experimental results, we discuss the conditions required for separating binary eutectic-forming vapors by sublimation.
Three‐Component One‐Pot Total Syntheses of Glyantrypine, Fumiquinazoline F, and Fiscalin B Promoted by Microwave Irradiation. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
ChemInform Abstract: QUINTET GROUND STATE OF A NON‐KEKULE TETRARADICAL 3,6‐DIMETHYLENEANTHRACENYL‐1,7‐DIOXY (1983)

Abstract Die Titelverbindung ( III) wurde durch aufeinanderfolgende Photolyse der beiden Brückenbindungen in dem pentacyclischen Diketon (I), das in sechs Stufen′ aus s‐Hyrindacen‐l ,7‐dion dargestellt werden kann, erhalten.
Remote Back Strain: A Strategy for Modulating the Reactivity of Triarylboranes (2023)

Abstract A strategy for modulating the Lewis acidity of triarylboranes is proposed based on the concept of remote back strain. Steric repulsion and noncovalent interactions, both generated between the aryl meta-substituents of triarylboranes, are found to be critical for determining the strength of the remote back strain. Applying this concept, we synthesized B[2,6-F2-3,5-(TMS)2-C6H]3 and the liquid B[2,6-F2-3,5-(allyl)2-C6H]3 and we demonstrated their superior catalytic activity for the hydrogenation of quinoline relative to B(C6F5)3 or B(2,6-F2C6H3)3. Moreover, we established the first example of the catalytic hydrogenation of quinoline by using B[2,6-F2-3,5-(allyl)2-C6H]3 in the presence of a gaseous 1:1:1 molar mixture of H2, CO, and CO2.
Supplementary Table 1 from MiR-122/Cyclin G1 Interaction Modulates p53 Activity and Affects Doxorubicin Sensitivity of Human Hepatocarcinoma Cells (2023)

Supplementary Table 1 from MiR-122/Cyclin G1 Interaction Modulates p53 Activity and Affects Doxorubicin Sensitivity of Human Hepatocarcinoma Cells
Supplementary Figures 1-4, Tables 1-2 from Dual IGF-I/II–Neutralizing Antibody MEDI-573 Potently Inhibits IGF Signaling and Tumor Growth (2023)

Supplementary Figures 1-4, Tables 1-2 from Dual IGF-I/II–Neutralizing Antibody MEDI-573 Potently Inhibits IGF Signaling and Tumor Growth
NanoComposite Stainless Steel Powder Technologies (2012)

new components through various powder metallurgy techniques (vacuum hot pressing, Dynaforge, and hot isostatic pressing). The unique fine scale distribution of microstructural features yields a material with high hardness and wear resistance compared to material produced through conventional processing techniques such as casting while maintaining adequate fracture toughness. Several compositions have been examined including those specifically designed for high hardness and wear resistance and a composition specifically tailored to devitrify into an austenitic matrix (similar to a stainless steel) which poses improved corrosion behavior.
Future trend of microprocessor design (2002)

this paper, we will examine key architectural and process technology trends that affect microprocessor designs in the next decade
Étude d'un Générateur Micro-cinétique: Modélisation Énergétique et Optimisation du Transfert d'Energie (2009)

National audience
WY-47,791 HCL: PRECLINICAL PROFILE OF A NOVEL POTENTIAL ANTIPSYCHOTIC AGENT (1992)

Abou-Gharbia, M.; Andree, T. H.; Marquis, K. L.; Moyer, J. A.; Haskins, J. T.; Muth, E. Author Information
A Software-Defined Phased Array Radio with mmWave to Software Vertical Stack Integration for 5G Experimentation (2018)

The paper introduces a software-defined phased array radio (SDPAR) operating around the 5G NR frequency band of 28 GHz. The highly re-configurable phased array radio features beam shaping/steering control as well as data TX/RX function control from a single Python-based software interface. High speed phased array control and configuration functions are enabled by extensive on-chip digital circuits co-integrated with mmWave circuit blocks to achieve agile beam-steering and beam-shaping functions. Beams are formed using up to 128 independently controlled phased array elements using RF beamforming for groups of 16 elements, and IF/digital beamforming thereafter. Both TX and RX capabilities are enabled in both H and V polarizations. These functions are accessed through a software stack providing a top level application programming interface (API) for user programmability. The same API also controls the data communication functions with both TX and RX capabilities enabling USRP-GNU radio functions at around 28 GHz frequency. In addition to the hardware platform, this paper presents a software-only SDPAR emulator to enable fast software-only development cycles prior to real-world experiments using the SDPAR hardware. The SDPAR system platform is expected to significantly benefit networking research for mmWave phased array systems, especially targeted toward 5G communications.
Natural Products Containing Medium‐Sized Nitrogen Heterocycles Synthesized by Ring‐Closing Alkene Metathesis (2010)

This chapter contains sections titled: Introduction Five-membered Nitrogen Heterocycles Six-membered Nitrogen Heterocycles Seven-membered Nitrogen Heterocycles Eight-membered Nitrogen Heterocycles Conclusion References
Exploiting Context-Awareness for Secure Spectrum Trading in Multi-hop Cognitive Cellular Networks (2016)

In this paper, we consider context-awareness to enhance route reliability and robustness in multi-hop cognitive networks. A novel context-aware route discovery protocol is presented to enable secondary users to select the route according to their QoS requirements. The protocol facilitates adjacent relay selection under different criteria, such as shortest available path, route reliability and relay reputation. New routing and security-based metrics are defined to measure route robustness in spatial, frequency and temporal domains. Secure throughput, defined as the percentage of traffic not being intercepted in the network, is provided. The resources needed for trading are then obtained by jointly optimizing secure throughput and trading price. Simulation results show that when there is a traffic imbalance of factor 4 between the primary and secondary networks, 4 channels are needed to achieve 90% link reliability and 99% secure throughput in the secondary network. Besides, when relay reputation varies from 0.5 to 0.9, a 20% variation in the required resources is observed.
Epstein‐Barr virus antagonizes the antiproliferative activity of transforming growth factor‐β but does not abolish its signaling (2002)

TGF-beta induces apoptosis and inhibits the proliferation of EBV-negative B-lymphoma cell lines. In contrast, EBV-immortalized B cells are resistant to both the proapoptotic and the antiproliferative activities of TGF-beta. We have generated a lymphoblastoid cell line, in which we can switch on and off the EBV-specific transcriptional program driven by EBNA2. When these cells express the EBNA2-driven phenotype, they are resistant to TGF-beta-mediated growth arrest. We used this cell line to readdress the question of how EBV can overcome the antiproliferative TGF-beta activity. We show here that EBV-driven cells remain TGF-beta-responsive since TGF-beta target genes are readily induced. Thus, EBV can overcome TGF-beta-mediated growth arrest without interfering with the core machinery of the TGF-beta signaling pathway, which links ligand binding to the induction of TGF-beta target genes.
Hybrid-Type Temperature Sensor Using Thin-Film Transistors (2014)

We have developed a hybrid-type temperature sensor using thin-film transistors. First, we evaluate temperature dependences of transistor characteristics and find that the temperature dependence of the off-leakage current is much larger than that of the on current. Next, we combine a transistor, capacitor, and ring oscillator to develop the hybrid-type temperature sensor and detect the temperature by measuring the oscillation frequency. The large temperature dependences of the off-leakage currents can be utilized, and simultaneously only a digital circuit is required to count the digital pulse.
Impact of a bladder cuff excision during radical nephroureterectomy on cancer specific survival in patients with upper tract urothelial cancer in Korea: a retrospective, multi-institutional study (2017)

In the present study, RNU without BCE resulted in significantly worse CSS in ureteral cancer patients, which indicated that BCE should be mandatory in patients with ureteral cancer.
Covalent fragment libraries in drug discovery (2020)

Targeted covalent inhibitors and chemical probes have become integral parts of drug discovery approaches. Given the advantages of fragment-based drug discovery, screening electrophilic fragments emerged as a promising alternative to discover and validate novel targets and to generate viable chemical starting points even for targets that are barely tractable. In this review, we present recent principles and considerations in the design of electrophilic fragment libraries from the selection of the appropriate covalent warhead through the design of the covalent fragment to the compilation of the library. We then summarize recent screening methodologies of covalent fragments against surrogate models, proteins, and the whole proteome, or living cells. Finally, we highlight recent drug discovery applications of covalent fragment libraries.
Novel Aromatic Fluoroolefins via Fluoro-Julia-Kocienski Olefination (2010)

Fluoroolefins, which play an increasingly important role as peptide mimics in pharmaceuticals and as crop protection agents, are generated using a fluoro-Julia-Kocienski olefination. Their preparation can easily be accomplished using a Mitsunobu reaction and subsequent oxidation to generate the required benzothiazolyl sulfones. The key step of this process was the electrophilic α-fluorination of the sulfone with N-fluorobenzenesulfonimide. The last stage of the successful synthesis of the fluoroolefins was the modified Julia-Kocienski olefination under basic conditions. Further functionalization was followed with the application of a Suzuki reaction.
Improvement of Heat Transfer Performance of Turbulence Promoter Ribs (2006)

Numerical and experimental approaches were taken to improve the heat transfer performance of V-shaped staggered (VSG) ribs. At first, a numerical method using Large Eddy Simulations (LES) was employed to determine the effect of VSG rib-induced flow on the local heat transfer coefficient distributions. The results revealed that the secondary flows generated by the rib configuration carry cold coolant air from the passage core region to the rib-roughened wall, thus enhancing heat transfer. Conversely, behind each rib there is a recirculation zone that does not contribute to enhanced heat transfer. Based on said results, six types of the advanced V-shaped staggered (AVSG) rib configurations were proposed. The test apparatus employing a comparative method was used to measure the total heat transfer coefficient and pressure loss coefficient of the VSG and AVSG ribs. It was concluded that thermal performance of the most effective type was 25% higher than that of VSG.
3D and 2D silicon photonic crystals for microphotonic circuits (2003)

Summary form only given. Photonic crystals might offer a unique solution for building ultradense photonic integrated circuits. Recent achievements in fabrication of silicon photonic crystals compatible with microelectronics processing will be reported.
Wear resistance and friction reduction in acrylo nitrile butadiene rubber through hybrid combination of graphite flakes and nano tungsten disulphide (2016)

Friction and wear have considerable role in the life span of two interacting parts. Incorporation of nanofillers in polymers/elastomers matrix causes commendable changes in its tribologicalproperties. The main purpose of this work is to reduce the coefficient of friction and wear rate of Acrylo Nitrile Butadiene rubber (NBR). To achieve such objective traditionally well knownlubricants graphite(G), tungsten disulphide (WS2) and there hybrid combination was incorporated in NBR matrix. Effect of applied load (force) and concentration of fillers on tribological properties of NBR had been studied. The filler incorporation enhanced the hardnessby 8%, showed resistance to hydraulic oil and aging effect also got improved significantly. A particular optimized concentration of NBR with hybrid combination of 2% WS2 and 4% Graphite showed minimum coefficient of friction as well as wear rate. A hypothesis could be attributed that similar lamellar structure of WS2 and Graphite along with formation of a stable nanoscale disulfide tribofilmcould result in lowering of friction. These substantially improved properties of nanoreinforced rubber materials would definitely pave promising path for plethora of potential technological applications.