gebhart/patrepeval huggingface dataset:
Learning contact locations for pushing and orienting unknown objects (2013)

We present a method by which a robot learns to predict effective contact locations for pushing as a function of object shape. The robot performs push experiments at many contact locations on multiple objects and records local and global shape features at each point of contact. Each trial attempts to either push the object in a straight line or to rotate the object to a new orientation. The robot observes the outcome trajectories of the manipulations and computes either a push-stability or rotate-push score for each trial. The robot then learns a regression function for each score in order to predict push effectiveness as a function of object shape. With this mapping, the robot can infer effective push locations for subsequent objects from their shapes, regardless of whether they belong to a previously encountered object class. These results are demonstrated on a mobile manipulator robot pushing a variety of household objects on a tabletop surface.
Throughput Performance of MC-CDMA HARQ using Space-Time Block Coded-Joint Transmit/Receive Diversity (2009)

Hybrid automatic repeat request (HARQ) is an indispensable error control technique for wireless packet access. A combination of multi-carrier code division multiple access (MC-CDMA) and HARQ can provide a good throughput performance in a severe frequency-selective fading channel. Recently, we proposed the space-time block coded-joint transmit/receive diversity (STBC-JTRD), which allows an arbitrary number of transmit antennas while limiting the number of receive antennas to 6. In this paper, we evaluate, by computer simulation, the throughput performance of MCCDMA HARQ using STBC-JTRD, and show that the STBCJTRD provides a better throughput performance than the spacetime block coded transmit diversity (STTD).
Complete nucleotide sequence of a molecular clone of woodchuck hepatitis virus that is infectious in the natural host. (1989)

Woodchuck hepatitis virus (WHV) DNA was cloned from viral particles obtained from the serum of a woodchuck with a naturally acquired infection. The complete nucleotide sequence of the virus genome was determined and found to be 3323 base pairs long. Transfection experiments demonstrated that the recombinant WHV DNA was infectious in each of 18 woodchucks tested and established a chronic carrier state in 1 of 13 neonates and 3 of 5 adult animals. WHV DNA from serum particles from the chronically infected neonate was cloned and the nucleotide sequence of three independent recombinants was compared directly with that of the input recombinant DNA. The consensus sequence of the three progeny genomes was identical to that of the parental DNA sequence. Therefore, transfection of woodchuck livers with recombinant WHV DNA induces active virus replication and gene expression and yields progeny genomes that are faithful copies of the input virus genome.
Facile construction of unmarked deletion mutants in Burkholderia pseudomallei using sacB counter-selection in sucrose-resistant and sucrose-sensitive isolates (2008)

Burkholderia pseudomallei is the causative agent of melioidosis, a potentially fatal disease endemic or emerging world-wide. Here we report unmarked allele-replacement mutagenesis using efficient sacB counter-selection. Despite being genotypically sacB(+), most commonly used B. pseudomallei strains are sucrose-resistant and efficient sacB counter-selection is demonstrated in both resistant and sensitive strains.
Additive Manufacturing (2017)

No AccessUnderstanding Polymer ProcessingOct 2017Additive ManufacturingDominik Rietzel, Martin Friedrich, Tim A. OsswaldDominik RietzelSearch for more papers by this author, Martin FriedrichSearch for more papers by this author, Tim A. OsswaldSearch for more papers by this authorhttps://doi.org/10.3139/9781569906484.007SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2017Pages: 147-169Print ISBN: 978-1-56990-647-7eISBN: 978-1-56990-648-4 Copyright & Permissions© 2017 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
Analysis of multi-sensor radar detection based on the TBD-HT approach in ECM environment (2010)

This paper describes in details the performance of an advanced detecting algorithm for multi-sensor target Track Before Detection (TBD) through the Hough Transform (HT). The detection algorithm employs the idea of using the Hough Transform for joint detection of linear trajectory targets. The polar modification of the TBD-HT approach is applied to a multi-sensor Polar Hough detector for multi-sensor target/trajectory detection in ECM environment with a Stand-off-Jammer (SOJ). A CFAR detector is proposed for signal detection in the (r-t) space instead of fixed thresholding in order to enhance the target detectability in ECM environment. In this paper a centralized structure of a multi-sensor Polar Hough detector is considered. The expressions calculating the probability characteristics, i.e. the probability of target/trajectory detection and the false alarm probability, are analytically derived. The multi-channel TBD-HT detector probability characteristics are compared with those for the conventional signal processing.
5.94 Tb/s capacity of a multichannel tunable - 700 to - 1200 ps/nm dispersion compensator (2005)

The capacity limit of a thermally controlled fiber Bragg grating-based chromatic dispersion compensator is investigated. An equivalent quasi error-free 5.94 Tb/s capacity is demonstrated when dispersion of up to 73.8 km of SSMF is compensated. (2 pages)
Vitreal Oxygenation in Retinal Ischemia Reperfusion (2010)

In severe total ocular ischemia, anterior vitreal oxygenation supplies enough oxygen to penetrate the retinal thickness, resulting in rescue of the RPE/choriocapillaris that continues to perfuse, hence sparing the retinal tissue from damage.
Translational Implications for Radiosensitizing Strategies in Rhabdomyosarcoma (2022)

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood and adolescence that includes FP-RMS, harboring the fusion oncoprotein PAX3/7-FOXO1 and FN-RMS, often mutant in the RAS pathway. Risk stratifications of RMS patients determine different prognostic groups and related therapeutic treatment. Current multimodal therapeutic strategies involve surgery, chemotherapy (CHT) and radiotherapy (RT), but despite the deeper knowledge of response mechanisms underpinning CHT treatment and the technological improvements that characterize RT, local failures and recurrence frequently occur. This review sums up the RMS classification and the management of RMS patients, with special attention to RT treatment and possible radiosensitizing strategies for RMS tumors. Indeed, RMS radioresistance is a clinical problem and further studies aimed at dissecting radioresistant molecular mechanisms are needed to identify specific targets to hit, thus improving RT-induced cytotoxicity.
Author response: Tight nanoscale clustering of Fcγ receptors using DNA origami promotes phagocytosis (2021)

The word ‘phagocytosis’ means cellular eating. It is the process by which cells extend their membranes around foreign particles and engulf them. Macrophages, a type of immune cell found in every tissue of the body, perform phagocytosis to eat pathogens and diseased cells. To avoid eating healthy cells, macrophages focus on targets marked by proteins called antibodies. They look for cells coated with high levels of a type of antibody called immunoglobulin G, or IgG for short, but only eat cells coated with enough IgG, raising the question, can macrophages count? Macrophages recognize IgG antibodies using cell surface receptors called Fc-gamma Receptors. When these receptors bind to IgG, they cluster together. Researchers do not yet know how the number of IgG antibodies per cluster, or the spacing between them, affects phagocytosis. To find this out, researchers need to be able to manipulate the clustering experimentally. One way to do this is using a technique called DNA origami. This technique creates nanoscale patterns of DNA strands on a target surface. If the part of a receptor that interacts with its target is then replaced with a complementary DNA strand to the strands on the target surface, the receptor will bind the surface following the nanoscale pattern. This allows researchers to generate synthetic targets with specific patterns of receptor-target interaction. Kern et al. replaced the part of the macrophage Fc-gamma Receptor that interacts with IgG with a strand of DNA. They then used DNA origami to arrange complementary DNA strands on pegboards and attached these pegboards to silica beads. The different arrangements of DNA on these pegboards mimicked the types of antibody clusters macrophages might encounter on the surfaces of the cells and particles they have to engulf in the body. Kern et al. found that tight clusters of the DNA targets on the pegboards made the macrophages most likely to begin phagocytosis, particularly clusters of eight or more DNA strands spaced less than seven nanometers apart. Macrophages encountering these tight clusters showed an increase in Fc-gamma receptor activation, which is crucial for macrophage attack. Whether or not macrophages can count, they can at least sense the level of clustering of IgG antibodies to determine if a target should be engulfed. Doctors use antibody therapies that rely on Fc-gamma receptor engagement to treat cancer, autoimmune and neurodegenerative diseases. Understanding how clustering affects phagocytosis could aid in the design of new antibody treatments. It could also help improve the design of synthetic receptors to create designer immune cells that can attack specific targets. The next step will be to recreate the results from the synthetic system used by Kern et al. with natural receptors and antibodies.
Mechanisms underlying ICU muscle wasting and effects of passive mechanical loading (2012)

Mechanical silencing is suggested to be a primary mechanism underlying CIM; that is, triggering the myosin loss, muscle wasting and myosin PTMs. The higher neuronal nitric oxide synthase expression found in the ICU patients and its cytoplasmic translocation are forwarded as a probable mechanism underlying these modifications. The positive effect of passive loading on muscle fiber function strongly supports the importance of early physical therapy and mobilization in deeply sedated and mechanically ventilated ICU patients.
<title>Applying genetic algorithms to the state assignment problem: a case study</title> (1992)

Finding the best state assignment for implementing a synchronous sequential circuit is important for reducing silicon area or chip count in many digital designs. This State Assignment Problem (SAP) belongs to a broader class of combinatorial optimization problems than the well studied traveling salesman problem, which can be formulated as a special case of SAP. The search for a good solution is considerably more involved for the SAP than it is for the traveling salesman problem due to a much larger number of equivalent solutions, and no effective heuristic has been found so far to cater to all types of circuits. In this paper, a matrix representation is used as the genotype for a Generic Algorithm (GA) approach to this problem. A novel selection mechanism is introduced, and suitable genetic operators for crossover and mutation, are constructed. The properties of each of these elements of the GA are discussed and an analysis of parameters that influence the algorithm is given. A canonical form for a solution is defined to significantly reduce the search space and number of local minima. Simulation results for scalable examples show that the GA approach yields results that are comparable to those obtained using competing heuristics. Although a GA does not seem to be the tool of choice for use in a sequential Von-Neumann machine, the results obtained are good enough to encourage further research on distributed processing GA machines that can exploit its intrinsic parallelism.
Application of Augmented Reality to Visualizing Anatomical Airways (2002)

Visualizing information in three dimensions provides an increased understanding of the data presented. Furthermore, the ability to manipulate or interact with data visualized in three dimensions is superior. Within the medical community, augmented reality is being used for interactive, three-dimensional (3D) visualization. This type of visualization, which enhances the real world with computer generated information, requires a display device, a computer to generate the 3D data, and a system to track the user. In addition to these requirements, however, the hardware must be properly integrated to insure correct visualization. To this end, we present components of an integrated augmented reality system consisting of a novel head-mounted projective display, a Linux-based PC, and a commercially available optical tracking system. We demonstrate the system with the visualization of anatomical airways superimposed on a human patient simulator.
Relationship between Full-Thickness Macular Hole Onset and Posterior Vitreous Detachment (2023)

The author(s) have no proprietary or commercial interest in any materials discussed in this article.
Experimental investigation on CFRP strengthened steel plates with inclined cracks (2016)

Recently, a considerable amount of researches has been conducted on CFRP strengthened metallic members under fatigue tension test (Liu et al. 2009, Ghafoori et al. 2012). However, it is not clear whether CFRP strengthening has the same performance and efficiency under mixed mode loading (I + II). This paper aims to extend the current knowledge of CFRP strengthening under tensile fatigue loading to the case of mixed mode loading. An experimental program has been designed for this purpose, including 18 steel specimens, 12 of them reinforced by CFRP. Central cracked tensile steel specimens manufactured with a central hole of 5 mm, two slits of 0.9 mm, and constant dimensions of (500 x 90 x 10) mm. The mixed mode conditions were stimulated by initiating different degrees of crack inclination with respect to the loading axis in the steel plate specimens within a range of (10°–90°). UHM-CFRP laminates were applied on one side of the steel plates using two configurations; fully reinforced- & partially reinforced steel plates. Uniaxially cyclic loading with a constant stress range of 135 MPa, a stress ratio of 0.1, and a frequency of 20 Hz were applied for all the specimens. Crack propagation versus fatigue cycles were measured using beach marking technique. Test results showed that fatigue lives of steel plates were increased directly with increasing the mode mixity (I + II), i.e. for specimen has crack inclined with 45°, the fatigue life was almost doubled, as stress intensity factor (SIF) of mode I decreased at the crack tip. Life extension, due to CFRP strengthening system, was extended by 1.54–2.27 times with marginal decrease as the shear stress component was increased. In this study, a “shifting phenomenon” was found, i. e. the mixed mode crack growth curve (β ˂ 90°) can be approximated to the same crack growth curve as mode I (β = 90°) with a shift, as illustrated in Figure 1. This shifting phenomenon applies to both unrepaired and CFRP repaired cases. From this point, a new method will be developed by the authors to estimate the total fatigue life of CFRP strengthened plates with inclined cracks using modification factors for the mode I crack growth curves. Figure 1 Schematic view of the shifting phenomenon in mixed-mode fatigue crack growth curves. https://s3-euw1-ap-pe-df-pch-content-public-p.s3.eu-west-1.amazonaws.com/9781315207681/cd556cd4-4dcf-4efe-8e29-56fc67b8bfbd/content/fig56_1.tif"/>
Indiana O’Brien Center for Advanced Microscopic Analysis (2014)

The primary goal of this Center is to develop new optical methodologies for investigators in Nephrologic and Urologic Research and to make the technology widely accessible to the renal
The use of static power convertor equipment to increase the efficiency of operation power station plant (1988)

The author deals with the particular beneficial uses to which thyristor power convertors can be put in power stations with specific reference to updating existing ones. The most important area is in the supply of feed water to the steam generating boilers and in the control over the air flow in the boiler to achieve the optimum combustion conditions for the fuel. The second area is in the provision of excitation power to the alternators. With the continuing reductions in the price of static power thyristor equipment compared to that of rotating plant it is now economic and, in fact, more efficient to use thyristor convertors to provide the alternator's excitation power as well as to control it. By such means it is also possible for the control to be faster and more precise enabling fault conditions and sudden load application or removal to be coped with more effectively. >
CAPPED METAL CLUSTERS IN THE GAS PHASE (2005)

Alkanethiol protected gold clusters of 29 kDa were prepared and separated by column chromatography. Laser desorption mass spectra of these clusters have been investigated. In the gas phase, monolayer–monolayer interaction leads to clustering of the protected clusters. Role of different matrices and effect of alkanethiol chain length on this process have been investigated.
Oral amino acids and testosterone therapy to improve muscle mass and quality of life during chemotherapy in recurrent cervical cancer: A case study (2010)

Muscle wasting is by far the most important phenotypic feature of cancer cachexia, though little success has been achieved toward reversing or preventing this catabolic process. Anabolic interventions including testosterone and amino acid supplements may be beneficial in reducing and/or reversing muscle wasting in these patient populations. A 48‐year‐old recurrent cervical cancer patient was scheduled to receive three 21‐day cycles of cisplatin and topotecan chemotherapy. She consented to a 10 week blinded interventional pilot study were she received daily amino acid supplements and weekly injections of testosterone enanthate before and during the weeks of chemotherapy treatment. Blood, Dual Energy X‐ray Absorptiometry (DEXA) scans, and Functional Assessment of Cancer Therapy ‐ General (FACT‐G) questionnaire data were collected before and after the 10 week period. Total serum testosterone concentrations, total and trunk lean body mass, and body weight increased after 10 weeks. Total and trunk fat mass decreased. FACT‐G scores improved. Concomitant treatment of oral amino acids and testosterone may be a viable therapeutic option for fighting cachexia and improving quality of life during chemotherapeutic treatment of recurrent cervical cancer. A double‐blinded, placebo‐controlled interventional study is in progress (NCT00878995). Funding through NIH/NCI RO1 CA127971 and T32 CA117834.
Cleavage of the transactivation-inhibitory domain of p63 by caspases enhances apoptosis (2007)

p63 is a p53-related transcription factor. Utilization of two different promoters and alternative splicing at the C terminus lead to generation of six isoforms. The alpha isoforms of TAp63 and DeltaNp63 contain a transactivation-inhibitory (TI) domain at the C termini, which can bind to the transactivation (TA) domain and inhibit its transcriptional activity. Consequently, TAp63alpha can directly inhibit its activity through an intramolecular interaction; similarly, DeltaNp63alpha can inhibit the activity of the active TAp63 isoforms through an intermolecular interaction. In this work, we demonstrate that after induction of apoptosis, the TI domain of the p63alpha isoforms is cleaved by activated caspases. Cleavage of DeltaNp63alpha relieves its inhibitory effect on the transcriptionally active p63 proteins, and the cleavage of TAp63alpha results in production of a TAp63 protein with enhanced transcriptional activity. In agreement with these data, generation of the N-terminal TAp63 fragment has a role in apoptosis because stable cell lines expressing wild-type TAp63 are more sensitive to apoptosis compared with cells expressing the noncleavable mutant. We also used a model system in which TAp63 expression was induced by trichostatin-A treatment in HCT116 cells. Trichostatin-A sensitized these cells to apoptosis, and this sensitization was associated with cleavage of up-regulated p63.
Multiscale Manifold Representation and Modeling (2006)

Many real world data sets can be viewed as points in a higher-dimensional space that lie concentrated around a lower-dimensional manifold structure. We propose a new multiscale representation for such point clouds based on lifting and perfect matching. The result is an adaptive wavelet transform that decomposes a point cloud into manifold approximations and details at multiple scales. We illustrate with several examples that the transform can extract an unknown smooth manifold from noisy point cloud samples using simple wavelet thresholding ideas.
Self-Centering Energy Dissipative Bracing System for the Seismic Resistance of Structures: Development and Validation (2007)

Buildings designed according to modern seismic codes are expected to develop a controlled ductile inelastic response during major earthquakes, implying extensive structural damage after a design level earthquake, along with possibly substantial residual deformations. To address this drawback of traditional yielding systems, a new bracing system that can undergo large axial deformations without structural damage while providing stable energy dissipation capacity and a restoring force has recently been developed. The proposed bracing member exhibits a repeatable flag-shaped hysteretic response with full recentering capabilities, therefore eliminating residual deformations. The mechanics of this new system are first explained, the equations governing its design and response are outlined, and one embodiment of the system, which combines a friction dissipative mechanism and Aramid tensioning elements, is further studied. Results from component tests, full-scale (reduced length) quasi-static axial tests, and quasi-static and dynamic seismic tests on a full-scale frame system are presented. Experimental results confirm the expected self-centering behavior of the self-centering energy dissipative (SCED) bracing system within the target design drift. Results also confirm the validity of the design and behavior equations that were developed. It is concluded that the proposed SCED concept can represent a viable alternative to current braced frame systems because of its attractive self-centering property and because the simplicity of the system allows it to be scaled to any desired strength level.
Anti-Hu-Associated Autoimmune Limbic Encephalitis in a Patient with PD-1 Inhibitor-Responsive Myxoid Chondrosarcoma (2017)

Autoimmune encephalitis is an uncommon complication of immune checkpoint inhibitor therapy. This article reports a case of fatal anti-Hu-associated autoimmune limbic encephalitis presenting within 8 weeks following anti-PD1 therapy in a patient with myxoid chondrosarcoma and pre-existing anti-Hu antibodies. Although tumor reduction occurred in response to PD-1 inhibitor therapy, the patient had a rapidly progressive decline in neurologic function despite initial stabilization with immunosuppression. Considering the increasing use of immune checkpoint inhibitors for the treatment of various malignancies, an increase in the occurrence of neurologic adverse events is likely, requiring prompt intervention and enhanced pharmacovigilance in malignancies associated with onconeuronal antibodies.