gebhart/patrepeval huggingface dataset:
A diagnostic evaluation of serum human telomerase reverse transcriptase mRNA as a novel tumor marker for gynecologic malignancies (2007)

Human telomerase reverse transcriptase (hTERT) and epidermal growth factor receptor (EGFR) play an important role in many cancers including gynecological cancers. We previously reported the usefulness of a quantitative highly sensitive detection method for hTERT mRNA in the serum of cancer patients. By this method, we attempted to elucidate the diagnostic evaluation of serum hTERT mRNA for gynecologic malignancies. In 174 female patients with gynecological lesions (47 with ovarian lesions, 63 with uterine lesions, 2 with malignancies in other gynecological lesions, and 62 benign lesions) and 20 healthy individuals, we measured serum hTERT mRNA and EGFR mRNA by using the newly developed real-time quantitative RT-PCR. We examined their sensitivity and specificity in cancer diagnosis, clinical significance in comparison with conventional tumor markers, and their correlations with the clinical parameters by using multivariate analyses. Serum hTERT mRNA showed higher values in patients with gynecologic cancers than in those with benign diseases and healthy individuals. The hTERT mRNA level independently correlated with the presence of cancers (P=0.004 for both ovarian and uterine cancer) and clinical stage (P<0.001). The sensitivity and specificity of hTERT mRNA in cancer diagnosis was 74.4% and 74.1%, respectively. The hTERT mRNA level showed a significant correlation with CA125 by Pearson's relative test (P=0.035) and with histological findings in ovarian cancer by the Friedman test (P<0.004). EGFR mRNA did not display any differences between the diseases. hTERT mRNA is useful for diagnosing gynecologic cancer and is superior to conventional tumor markers. Therefore, serum hTERT mRNA is a novel and available biomarker for gynecologic malignancies.
Corrigendum: Role of Hippocampal Lipocalin-2 in Experimental Diabetic Encephalopathy (2019)

[This corrects the article DOI: 10.3389/fendo.2019.00025.].
Glycoengineering HIV-1 Env creates ‘supercharged’ and ‘hybrid’ glycans to increase neutralizing antibody potency, breadth and saturation (2018)

The extensive glycosylation of HIV-1 envelope (Env) glycoprotein leaves few glycan-free holes large enough to admit broadly neutralizing antibodies (bnAb). Consequently, most bnAbs must inevitably make some glycan contacts and avoid clashes with others. To investigate how Env glycan maturation regulates HIV sensitivity to bnAbs, we modified HIV-1 pseudovirus (PV) using various glycoengineering (GE) tools. Promoting the maturation of α-2,6 sialic acid (SA) glycan termini increased PV sensitivity to two bnAbs that target the V2 apex and one to the interface between Env surface gp120 and transmembrane gp41 subunits, typically by up to 30-fold. These effects were reversible by incubating PV with neuraminidase. The same bnAbs were unusually potent against PBMC-produced HIV-1, suggesting similar α-2,6 hypersialylated glycan termini may occur naturally. Overexpressing β-galactosyltransferase during PV production replaced complex glycans with hybrid glycans, effectively 'thinning' trimer glycan coverage. This increased PV sensitivity to some bnAbs but ablated sensitivity to one bnAb that depends on complex glycans. Other bnAbs preferred small glycans or galactose termini. For some bnAbs, the effects of GE were strain-specific, suggesting that GE had context-dependent effects on glycan clashes. GE was also able to increase the percent maximum neutralization (i.e. saturation) by some bnAbs. Indeed, some bnAb-resistant strains became highly sensitive with GE-thus uncovering previously unknown bnAb breadth. As might be expected, the activities of bnAbs that recognize glycan-deficient or invariant oligomannose epitopes were largely unaffected by GE. Non-neutralizing antibodies were also unaffected by GE, suggesting that trimers remain compact. Unlike mature bnAbs, germline-reverted bnAbs avoided or were indifferent to glycans, suggesting that glycan contacts are acquired as bnAbs mature. Together, our results suggest that glycovariation can greatly impact neutralization and that knowledge of the optimal Env glycoforms recognized by bnAbs may assist rational vaccine design.
Supplementary Figure 1 from IL-18 Induces PD-1–Dependent Immunosuppression in Cancer (2023)

Supplementary Figure 1 from IL-18 Induces PD-1–Dependent Immunosuppression in Cancer
Synthesis of application-specific highly efficient multi-mode cores for embedded systems (2005)

In this paper, we present a novel design methodology for synthesizing multiple configurations (or modes) into a single programmable core that can be used in embedded systems. Recent portable applications require reconfigurability of a system along with efficiency in terms of power, performance, and area. The field programmable gate arrays (FPGAs) provide a reconfigurable platform; however, they are slower in speed with significantly higher power and area than achievable by a customized application-specific integrated circuits (ASIC). Implementation of a system in either FPGA or ASIC represents a trade-off between programmability and design efficiency. In this work, we have developed techniques to realize efficient reconfigurable cores for a set of user-specified applications. The resultant system, named as multimode system, can easily switch configurations throughout the set of configurations it is designed for. A data flow graph transformation method coupled with efficient scheduling and allocation is used to automatically synthesize a Multi-Mode system from its behavior-level specifications. Experimental results on several applications demonstrate that our implementations can achieve about 60X power reduction on average and run 3.5X faster over corresponding FPGA implementations.
On Detecting Data Pollution Attacks On Recommender Systems Using Sequential GANs (2020)

Recommender systems are an essential part of any e-commerce platform. Recommendations are typically generated by aggregating large amounts of user data. A malicious actor may be motivated to sway the output of such recommender systems by injecting malicious datapoints to leverage the system for financial gain. In this work, we propose a semi-supervised attack detection algorithm to identify the malicious datapoints. We do this by leveraging a portion of the dataset that has a lower chance of being polluted to learn the distribution of genuine datapoints. Our proposed approach modifies the Generative Adversarial Network architecture to take into account the contextual information from user activity. This allows the model to distinguish legitimate datapoints from the injected ones.
Polyimide Nanofoams Based on Ordered Polyimides Derived from Poly(amic alkyl esters):  PMDA/4-BDAF (1997)

A means of generating foams of high-temperature polymers, polyimides, has been developed for use in dielectric layers in microelectronics. In these systems, the pore sizes generated are in the tens of nanometers range, thus the term “nanofoams”. The foams are generated by preparing phase-separated block copolymers with the majority phase comprised of polyimide and the minor phase consisting of a thermally labile block. Films are cast, solvent is removed, and the copolymers are cured, causing phase separation of the two blocks. The labile blocks are subsequently removed via thermal treatments leaving pores having a size and shape commensurate with the size and shape of the original copolymer morphology. The polyimide derived from pyromellitic dianhydride (PMDA) and 2,2-bis[4-(4-aminophenoxy)phenyl]hexafluoropropane (4-BDAF) was used as the matrix materials for the generation of nanofoams, and poly(propylene oxide) oligomers were used as the thermally labile constituent. The synthesis and characterization of the copolymers were performed, and the process for obtaining nanofoams was optimized. The foams were characterized by a variety of techniques including TEM, SAXS, WAXD, DMTA, density, and refractive index measurements. Thin-film, high-modulus foams with good mechanical properties can be synthesized using the copolymer/nanofoam approach.
Hypnosis to reduce fear of falling in hospitalized older adults: a pilot randomized controlled trial. (2023)

Abstract Background: Fear of falling is associated with numerous negative health outcomes in older adults and can limit the rehabilitation process. Hypnosis is now recognized as an effective treatment for a variety of conditions, especially anxiety and pain, which can be integrated safely with conventional medicine. The objective of this study was to assess the feasibility and acceptability of a hypnosis intervention in hospitalized older adults to reduce fear of falling. Methods: In this pilot feasibility randomized controlled trial, thirty-two older patients, hospitalized in geriatric rehabilitation wards, were randomly allocated (1:1 ratio) to either an intervention group (hypnosis, 2 sessions, one per week, plus usual rehabilitation program) or a control group (usual rehabilitation program only). Clinical assessors and statistician were blinded to group allocation. Primary outcomes were recruitment rate, retention rate and adherence to the intervention. Exploratory outcomes, analyzed according to the intention-to-treat principle, included impact of hypnosis on fear of falling (assessed by a new scale perform-FES), functional status, in-hospital falls, and length of hospital stay. Results: Of the 57 patients screened, 32 were randomized: 15 in the intervention group and 17 in the control group. Recruitment rate was 1.3 patients per week. The recruitment of the population sample was achieved in 5.5 months. The retention rate did not differ significantly between groups and a good adherence to the hypnosis intervention was achieved (77% of patients received the full intervention). No adverse event related to the hypnosis intervention was observed. Regarding exploratory clinical outcomes, no differences were found between groups on any outcome. Conclusion: Hypnosis is feasible and well accepted in a geriatric hospitalized population undergoing rehabilitation. Further pilot work should be conducted, with an increased number of hypnosis sessions, before conducting a full-scale trial to conclude whether or not hypnosis is effective to reduce fear of falling. Trial registration: ClinicalTrials.gov, NCT04726774. Registered 27 january 2021, retrospectively registered, https://clinicaltrials.gov/ct2/show/record/NCT04726774 Funding: Geneva University Hospitals, Research and Development Project (9-2018-I)
Experimental beating the standard quantum limit under non-markovian dephasing environment (2022)

Entanglement enhanced quantum metrology has been well investigated for beating the standard quantum limit (SQL). However, the metrological advantage of entangled states becomes much more elusive in the presence of noise. Under strictly Markovian dephasing noise, the uncorrelated and maximally entangled states achieve exactly the same measurement precision. However, it was predicted that in a non-Markovian dephasing channel, the entangled probes can recover their metrological advantage. Here, by using a highly controlled photonic system, we simulate a non-Markovian dephasing channel fulfill the quadratic decay behaviour. Under such a channel, we demonstrate the GHZ states can surpass the SQL in a scaling manner, up to six photons. Since the quadratic decay behavior is quite general for short time expansion in open quantum systems (also known as the quantum Zeno effect), our results suggest a universal and scalable method to beat the SQL in the real-word metrology tasks.
RAPID DNA HYBRIDIZATION REACTIONS USING ISOTACHOPHORESIS (2011)

We use ITP to control and increase the rate of homogenous DNA hybridization reactions. We present a novel physical model, new validation experiments, and new demonstrations of this assay. We studied the coupled physics and chemistry of the dynamics of preconcentration, mixing, and chemical reaction kinetics under ITP. Our experimentally-validated model enables closed form solution for two-species hybridization reaction under ITP, and predicts 10,000 fold speed-up of chemical reaction rate at concentrations of order 10 pM, with greater enhancement of reaction rate at lower concentrations. We experimentally demonstrate 800 fold speed-up using ITP compared to the standard case of reaction in a simple, well mixed reaction chamber.
ChemInform Abstract: Host‐Guest Chemistry of Main Group Clusters: Fullerenes and Carboranes (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Magnetic Properties of Conjugated Phenoxy Polyradicals (1990)

Abstract Formation and magnetic properties of π-conjugated phenoxy radicals bearing a porphyrin macrocycle or a polyacetylenic backbone are described. Tetrakis(3,5-di-t-butyl-4-hydroxyphenyl)porphinato-metals (7-M) [M = Zn(II), VO(II), and Cu(II)] were oxidized to give the corresponding stable monoradical and biradical. Magnetic properties of the radical species depend on the magnetic orbital of the central metal ion. ESR hfs structure reveals that the biradical for 7-Zn and—VO are in the triplet (S = 1) and quartet state (S = 3/2), respectively. Poly(3,5-di-t-butyl-4-hydroxyphenylacetylene) (8) and poly(p-ethynylphenylhydrogalvinoxyl) (9) with molecular weights of ∼ /104 are characterized. ESR spectra with hyperfine structure for 8 indicate that the phenoxy radicals are conjugated with the polyacetylenic main chain over ∼7 monomer units as a “neutral soliton.” Formed polyradicals for 8 and 9 are surprisingly stable, even in the solid state, due to resonance stabilization and/or steric effect of the conjugated main chain. An antiferromagnetic interaction is observed for oxidized 8 with a spin concentration above 10 mol%.
Differential Evolution of MAGE Genes Based on Expression Pattern and Selection Pressure (2012)

Starting from publicly-accessible datasets, we have utilized comparative and phylogenetic genome analyses to characterize the evolution of the human MAGE gene family. Our characterization of genomic structures in representative genomes of primates, rodents, carnivora, and macroscelidea indicates that both Type I and Type II MAGE genes have undergone lineage-specific evolution. The restricted expression pattern in germ cells of Type I MAGE orthologs is observed throughout evolutionary history. Unlike Type II MAGEs that have conserved promoter sequences, Type I MAGEs lack promoter conservation, suggesting that epigenetic regulation is a central mechanism for controlling their expression. Codon analysis shows that Type I but not Type II MAGE genes have been under positive selection. The combination of genomic and expression analysis suggests that Type 1 MAGE promoters and genes continue to evolve in the hominin lineage, perhaps towards functional diversification or acquiring additional specific functions, and that selection pressure at codon level is associated with expression spectrum.
Interaction Between Vanadium in Gas Turbine Fuels and Sulfidation Attack (1972)

The relationship between vanadium present in fuels, alkali salts present in the intake air and/or fuel, and the accelerated oxidation phenomena called sulfidation attack was investigated. The relative vapor pressure of alkali vanadates was determined and based upon the available thermodynamic data, and it was found the presence of vanadium can suppress condensation of alkali sulfates. It was also found that alkali vanadates, are, like the alkali sulfates, highly corrosive with respect to nickel base alloys.
P-OS5-1 Heat transfer analysis of the micro-thermoelectric gas sensor for sensitive gas detection (2012)

The thermoelectric gas sensor (TGS) has unique and reliable working principle, a synergetic combination of catalytic combustion and thermoelectric conversion. We analyze the heat balance of TGS for the improvement of the thermal design of TGS for the efficient transport of the catalytic combustion heat, and the voltage signal of TGS was simulated. The simulation parameters was calculated by comparing an experimental result with a calculation result. In order to confirm the effect of a dummy film, the voltage signal of TGS with and without dummy film by a change of heater power were compared.
Effects of Teneligliptin on HbA1c levels, Continuous Glucose Monitoring-Derived Time in Range and Glycemic Variability in Elderly Patients with T2DM (TEDDY Study) (2021)

Teneligliptin effectively reduced HbA1c levels, time spent above the target range, and glycemic variability, without increasing hypoglycemia in our study population.
A transferable tight-binding potential for carbon (1992)

An interatomic potential for carbon is developed that is based on an empirical tight-binding approach. The model reproduces accurately the energy-versus-volume diagram of carbon polytypes and gives a good description of the phonons and elastic constants for carbon in the diamond and graphite structures. To test the transferability of the model to different environments further, the authors performed molecular-dynamics simulations to study the liquid phase and the properties of small carbon microclusters. The results obtained are in good agreement with those obtained from ab initio calculations.
Third Harmonic Generation in ultrathin epsilon-near-zero material. (2017)

Abstract not provided.
Modelica Applications for Camless Engine Valvetrain Development (2002)

Several variable valvetrain technologies are being aggressively pursued to increase vehicle fuel economy and reduce engine exhaust emission levels. Electromechanical Valve Actuation (EMVA) is a promising alternative that uses electromagnetic actuators to replace the conventional camshaft and provide fully flexible valve timing control. This &amp;quot;camless &amp;quot; valvetrain provides new opportunities and challenges for engine control optimization. In this work, we present two Modelica applications for EMVA development. Control and prediction of the Air to Fuel (A/F) ratio in a port fuel injected spark-ignited (PFI SI) engine is an important factor for emissions, performance, and fuel
Neutron Research Community (1996)

The News & Comment article “U.S. neutron scientists settle for less” by Andrew Lawler ([9 Aug., p. 728][1]) provides a sobering assessment of the current status of neutron facilities in the United States and prospects for new ones. I take issue, however, with the description of the neutron research community as “small and fractious.” The “fractious” aspects of our community (as Lawler amply demonstrates) are mainly within the U.S. Department of Energy and its competing national laboratories, not among neutron researchers, the large majority of whom come from universities and industries. Nor is our community “small.” Well over 1000 physicists, chemists, materials scientists, and engineers participate in research in the United States every year using neutron beams, and this number has doubled in the last decade. As an example, researchers using the reactor at the National Institute of Standards and Technology, which has recently developed the only internationally competitive cold neutron research facility (CNRF) in the United States, have tripled since the opening of the CNRF in 1990. Moreover, these numbers do not reflect broad and critical U.S. needs for isotopes and irradiation facilities applied to medicine and technology, which also require modern neutron sources.

Unfortunately, our community has not benefited from development of a totally new neutron source in this country for more than 25 years, and we are continuing to fall behind our international competitors, a point clearly documented by Lawler. We must find a way to meet the increasing neutron research needs of modern U.S. science and technology. Even in the face of tight budgets, we in our field must unite to make a coherent case and set priorities for critically needed investments for a new neutron source and for upgrades to existing neutron facilities. This effort must be less concerned with the needs of any particular national laboratory than with providing the best capabilities for the nation. Failure to succeed in this mission could lead to a loss of any chance for the United States to be competitive in vital neutron measurements, nuclear medicine, and related technologies, as we move into the next century.

 [1]: /lookup/doi/10.1126/science.273.5276.728
Echo‐planar imaging of the central nervous system at 1.0 T (1992)

Echo-planar imaging (EPI) on the authors' 1-T prototype imager provides high-quality 100-msec images of the central nervous system. Contrast parameters can be chosen freely. Three-dimensional EPI sequences provide isotropically resolved data sets with 1-mm resolution. Brain perfusion and blood-brain barrier disruption can be assessed in time-course studies with gadopentetate dimeglumine. The current state of development of the authors' midfield research EPI system is discussed and its image quality illustrated through selected patient studies.
Defined chromosomal assignment of CLN5 demonstrates that at least four genetic loci are involved in the pathogenesis of human ceroid lipofuscinoses. (1994)

We demonstrate here that at least four genetically separate loci are involved in the pathogenesis of human neuronal ceroid lipofuscinoses (NCLs), fatal brain disorders of children. Earlier the assignments of the infantile and juvenile subtypes of NCL to 1p32 and 16p12 had revealed two loci; and here a variant subtype of the late-infantile form of NCL is mapped to a well-defined region on 13q21.1-q32, whereas the clinically similar, classical form of late-infantile NCL was found to represent the fourth, yet-unidentified NCL locus. The linkage disequilibrium was crucial for locus assignment in our highly limited family material, and the data exemplify the significance of this phenomenon in the random mapping of rare human diseases.
Combinatorial Fusion Criteria for Robot Mapping (2007)

We address the problem of sensor fusion for stereo and ultrasound depth measurements for map building for a robot operating in a cluttered environment. In such a situation it's difficult to make useful and realistic assumptions about the sensor or environment statistics. Combinatorial Fusion Analysis is used to develop an approach to fusion with unknown sensor and environment statistics. A metric is proposed that shows when fusion from a set of fusion alternatives will produce a more accurate estimation of depth than either sonar or stereo alone and when not. The metric consists of two criteria: (a) the performance ratio PR(A,B) between sensors A and B, and (b) the diversity d(A,B) between A and B as captured by the rank-score function fA and fB. Experimental results are reported to illustrate that these two CFA criteria are viable predictors to distinguish between positive cases (the combined system performs better than or equal to the individual systems) and negative cases.
VALIDATION OF SHIELDED CABLE MODELING IN XYCE BASED ON TRANSMISSION-LINE THEORY (2019)

Cables and electronic devices typically employ electromagnetic shields to prevent coupling from external radiation. The imperfect nature of these shields allows external electric and magnetic fields to induce unwanted currents and voltages on the inner conductor by penetrating into the interior regions of the cable. In this paper, we verify a circuit model tool using a previously proposed analytic model, by evaluating induced currents and voltages on the inner conductor of the shielded cable. Additionally, comparisons with experiments are also provided, aimed to validate the proposed circuit model. We foresee that this circuit model will enable coupling between electromagnetic and circuit simulations.