gebhart/patrepeval huggingface dataset:
Contrast-enhanced intravascular ultrasound: combining morphology with activity-based assessment of plaque vulnerability (2007)

Acute coronary syndromes are the result of coronary plaque rupture in the majority of cases. Available diagnostic techniques that focus on the early detection of plaques that are prone to rupture are still limited. Increased neovascularization in the vasa vasorum of the atherosclerotic plaque has been identified recently as a common feature of inflammation and plaque vulnerability. Microbubbles, which have been used for ultrasound imaging, can be used to trace neovascularization. We present recent advances in contrast agents and contrast-enhanced intravascular ultrasound that may be used for the detection of vasa vasorum, including fundamental and harmonic contrast imaging. Identification of vasa vasorum proliferation in atherosclerotic plaques presents important clinical implications; in particular it could provide a means to detect vulnerability in vivo, thereby guiding targeted treatments.
The whole world under your feet (2012)

Location-based services are increasingly popular, and the Earth has become covered with geotagged data. To assess a novel approach to access this information, we conducted a field trial of a mobile mixed reality application called MAA, which operates on a mobile phone. MAA displays a view through the Earth and geospatial content in the direction to which the user is pointing the device. In this paper, we report the results of the two-week long field trial of MAA. We found that the embodied usage of MAA is experienced as engaging and surprising, but may also be cumbersome in some usage situations. Virtual viewing of locations around the planet was considered pleasant. MAA was often shown to friends, and was used for watching visual materials and searching for information about cities. MAA was found to be a promising platform for many kinds of location-based content, especially for real-time events and local information.
Genotype-specific Features Reduce the Susceptibility of South American Yellow Fever Virus Strains to Vaccine-Induced Antibodies (2021)

Summary The resurgence of yellow fever in South America has prompted mitigation through vaccination against the etiologic agent, yellow fever virus (YFV). Current vaccines are based on a virulent African isolate, and their capacity to induce neutralizing antibodies against the vaccine strain is widely used as a surrogate for protection. However, the sensitivity of genetically distinct South American strains to vaccine-induced antibodies is unknown. Here, we show that antiviral potency of the polyclonal antibody response in both U.S. and Brazilian vaccinees is attenuated against an emergent Brazilian strain. This reduction was attributable to genetic changes at two sites in the central domain II of the glycoprotein E, including the acquisition of an N –linked glycosylation site, which are unique to and shared among most South American YFV strains. Our findings call for a reevaluation of current approaches to YFV immunological surveillance in South America and suggest approaches for designing updated vaccines.
Evaluating the Safety of Percutaneous Dorsolateral Talonavicular Joint Fixation in Modified Double Arthrodesis (2016)

Category: Hindfoot Introduction/Purpose: Hindfoot arthrodesis has demonstrated reliable long-term outcomes for treatment of symptomatic hindfoot arthritis, but the incidence of nonunion of the talonavicular joint has been reported as high as 29%. Retrograde percutaneous insertion of a dorsolateral screw in addition to the standard medial distal to proximal screw has been shown to add significant construct stiffness across the talonavicular joint in biomechanical testing. However, placement of this dorsolateral screw may result in increased neurovascular injury. The purpose of this cadaveric study was to investigate the proximity of important anatomic structures to dorsal, percutaneous, screw fixation across the talonavicular joint for hindfoot arthrodesis. Methods: 17 fresh frozen cadaveric limbs without deformity were transected across the supracondylar femur. A single fellowship-trained orthopedic surgeon performed all procedures. Percutaneous dorsolateral fixation across the talonavicular joint was performed with a cannulated screw. A 1.5-cm incision was created over the lateral third of the navicular after localization under fluoroscopy, and a 4.5 mm cannulated screw was inserted using standard AO technique. The guide wire was left within the screw. The incision was extended 2 cm proximal and distal and a separate orthopaedic surgeon used a caliper to measure the distance from the guide wire to the superficial peroneal nerve, extensor hallucis longus, extensor digitorum longus, deep peroneal nerve, and deep peroneal artery. Injuries to neurovascular structures were noted. Finally, solder wire was laid atop the deep neurovascular bundle to allow radiographic imaging of the screw and the bundle. Results: Injury to the deep neurovascular bundle occurred in 6 of 17 specimens (35.3%). There were 5 injuries (29.4%) to the deep peroneal nerve, 3 to the deep peroneal artery, and 2 to branches of the superficial peroneal nerve. The average distances from the guide wire to anatomic structures were superficial peroneal nerve: 1.8 mm (0.5-4.10 mm), extensor hallucis longus: 6.10 mm (0.6-15.0), extensor digitorum longus: 6.8 mm (0.5-14.0 mm), deep peroneal artery: 2.27 mm (0.0-5.1), and deep peroneal nerve: 2.4 mm (0.0-7.10 mm). Conclusion: A high rate of neurovascular injury was observed after percutaneous dorsolateral fixation across the talonavicular joint. These data suggest that this approach should be avoided in favor of an open approach, which allows identification and protection of the superficial peroneal nerve, extensor tendons, and the neurovascular bundle.
The Gastrointestinal Absorption Factor of Cobalt: A Study of Contamination Cases from French Nuclear Power Plants (1993)

Journal Article The Gastrointestinal Absorption Factor of Cobalt: A Study of Contamination Cases from French Nuclear Power Plants Get access C. Chevalier, C. Chevalier Search for other works by this author on: Oxford Academic PubMed Google Scholar M. Gonin M. Gonin Search for other works by this author on: Oxford Academic PubMed Google Scholar Radiation Protection Dosimetry, Volume 48, Issue 4, 1 August 1993, Pages 363–365, https://doi.org/10.1093/oxfordjournals.rpd.a081887 Published: 01 August 1993
Synthesis and pharmacological properties of an a-cyclodextrin assembled neuropeptide Y fragment (1999)

A symposium report. We report on the synthesis of TASP (template assembled synthetic proteins) mols. able to bind to neurotensin Y and angiotensin II receptors, in which a-cyclodextrin is used as template. [on SciFinder (R)]
Identification of ultrasound-contrast-agent dilution systems for cardiac quantification (2005)

This study presents a new minimally-invasive indicator dilution technique for cardiac quantification. An ultrasound contrast agent bolus is injected in a peripheral vein and detected by an ultrasound transducer. Several acoustic-intensity time curves are measured in specific regions of interest. After calibration, the resulting curves are processed by a Wiener deconvolution filter to identify the dilution system between different measurement sites, which is characterized by its impulse response function. This is interpolated and interpreted by specific models for the assessment of ejection fraction (EF) and pulmonary blood volume. The EF assessment is tested on a group of 20 patients with left ventricular EF going from 10% to 70%. The results show a 0.93 correlation coefficient with echographic hi-plane measurements. Blood volume measurements are validated in vitro and show a 0.99 correlation coefficient with the real volumes. The method feasibility is also tested in patients with promising results. In conclusion, the echographic identification of biological dilution systems is feasible. It allows a minimally invasive measurement of pulmonary blood volume and EF. The promising results encourage further validation and investigation for new applications.
Deciphering the Genome of Polyphosphate Accumulating Actinobacterium Microlunatus phosphovorus (2012)

Polyphosphate accumulating organisms (PAOs) belong mostly to Proteobacteria and Actinobacteria and are quite divergent. Under aerobic conditions, they accumulate intracellular polyphosphate (polyP), while they typically synthesize polyhydroxyalkanoates (PHAs) under anaerobic conditions. Many ecological, physiological, and genomic analyses have been performed with proteobacterial PAOs, but few with actinobacterial PAOs. In this study, the whole genome sequence of an actinobacterial PAO, Microlunatus phosphovorus NM-1(T) (NBRC 101784(T)), was determined. The number of genes for polyP metabolism was greater in M. phosphovorus than in other actinobacteria; it possesses genes for four polyP kinases (ppks), two polyP-dependent glucokinases (ppgks), and three phosphate transporters (pits). In contrast, it harbours only a single ppx gene for exopolyphosphatase, although two copies of ppx are generally present in other actinobacteria. Furthermore, M. phosphovorus lacks the phaABC genes for PHA synthesis and the actP gene encoding an acetate/H(+) symporter, both of which play crucial roles in anaerobic PHA accumulation in proteobacterial PAOs. Thus, while the general features of M. phosphovorus regarding aerobic polyP accumulation are similar to those of proteobacterial PAOs, its anaerobic polyP use and PHA synthesis appear to be different.
Abstract 1130: First-in-class KAT6A/KAT6B inhibitor CTx-648 (PF-9363) demonstrates potent anti-tumor activity in ER+ breast cancer with KAT6A dysregulation (2021)

Abstract KAT6A is a lysine histone acetyltransferase (HAT) of the MYST family of HATs. KAT6A, and its paralog KAT6B, have been shown to acetylate histone H3K23Ac and regulate diverse biological processes, including transcription, cell-cycle progression, stem cell maintenance and development. Molecular dysregulation of KAT6A has been observed in several cancers, including amplifications in breast, lung, ovarian cancer along with oncogenic fusions in AML. In breast cancer, KAT6A is amplified as part of the 8p11 amplicon in 10-15% of the patient population, which correlates with a worse clinical outcome in the estrogen receptor+ (ER+) subtype. Here we present identification of a first-in-class potent KAT6A/KAT6B tool inhibitor CTx-648 (PF-9363), that possesses high selectivity versus other MYST family members (KAT7, KAT5, KAT8) and other KATs, demonstrating anti-tumor activity in breast cancer. Using genetic and pharmacological approaches, we have demonstrated several ER+ breast cancer cell lines including KAT6A amplified and over-expressing models, are dependent on KAT6A enzymatic function. Epigenomic profiling studies using bulk and nascent RNA-seq combined with ATAC-seq revealed CTx-648 leads to downregulation of a specific set of genes involved in ESR1 pathway, cell cycle and stem cell pathways. In vivo target validation studies showed strong anti-tumor activity of CTx-648 in several ER+ breast cancer cell line and patient-derived xenograft models, including models harboring endocrine therapy resistance ESR1 mutations, highlighting promise for this novel therapy in ER+ breast cancer population. Based on the strength of the pre-clinical data, a selective KAT6 inhibitor (PF-07248144) is now commencing a Phase 1 clinical study in Advanced or Metastatic Solid Tumors. Citation Format: Shikhar Sharma, Jay Chung, Sean Uryu, Amanda Rickard, Natalie Nady, Showkhin Khan, Zhenxiong Wang, Yong Zhang, Haikuo Zhang, Pei-Pei Kung, Eric Greenwald, Karen Maegley, Patrick Bingham, Hieu Lam, Ylva E. Bozikis, Hendrik Falk, Elizabeth Allan, Vicky M. Avery, Miriam S. Butler, Michelle A. Camerino, Catalina Carrasco-Pozo, Susan A. Charman, Melissa J. Davis, Mark A. Dawson, Dawson Sarah-Jane, Melanie de Silva, Matthew L. Dennis, Olan Dolezal, Rachel Lagiakos, Geoffrey J. Lindeman, Laura MacPherson, Stewart Nuttall, Thomas S. Peat, Bin Ren, Alexandra E. Stupple, Elliot Surgenor, Chin Wee Tan, Tim Thomas, Jane E. Visvader, Anne K. Voss, Francois Vaillant, Karen L. White, James Whittle, Yuqing Yang, Soroor Hediyeh-Zadeh, Paul A. Stupple, Ian P. Street, Brendon J. Monahan, Thomas Paul. First-in-class KAT6A/KAT6B inhibitor CTx-648 (PF-9363) demonstrates potent anti-tumor activity in ER+ breast cancer with KAT6A dysregulation [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr 1130.
Role of Leukocyte Immunoglobulin G Receptors in Vaccine‐Induced Immunity toStreptococcus pneumoniae (2003)

Members of the leukocyte immunoglobulin (Ig) G receptor (FcgammaR) family play a key role in antibody-mediated phagocytosis and can either enhance antigen presentation or down-modulate immune responses. We studied immune responses to a pneumococcal conjugate (pneumococcal polysaccharide serotype 1 [PPS1]-tetanus toxoid) and antibody-mediated protection in mice deficient for individual FcgammaRs and complement receptor 3 (CR3). FcR gamma chain-deficient (FcR gamma chain(-/-)) mice, which lack expression of both FcgammaRI and III, had significantly lower anti-PPS1 IgG2b and IgG3 responses than did wild-type mice, whereas FcgammaRII-deficient (FcgammaRII(-/-)) mice had significantly higher IgG2a and IgG3 titers. Wild-type and FcgammaRII(-/-) mice were protected against infection with pneumococcal serotype 1, whereas immunized FcR gamma chain(-/-) and FcgammaRIII-deficient mice were not. Immunized CR3-deficient mice were protected against disease, and complement depletion had little effect on protection. These data indicate that activatory leukocyte FcgammaR, but not FcgammaRII (a murine homologue of human FcgammaRIIb), contributes to IgG-mediated protection against pneumococcal disease.
Use of Robotic Technology in Cam Type Osteochnodroplasty (2013)

Introduction:Cam type femoroacetabular impingement (FAI) may lead to osteoarthritis (OA)[1]. In 2D studies, an alpha angle greater than 55° was considered abnormal however limitations of 2D alpha angle measurement have led to the development of 3D methods [2–4]. Failure to completely address the bony impingement lesions during surgery has been the most common reason for unsuccessful hip arthroscopy surgery [5]. Robotic technology has facilitated more accurate surgery in comparison to the conventional means. In this study we aim to assess the potential application of robotic technology in dealing with this technically challenging procedure of cam sculpting surgery.Methods:CT scans of three patients' hips with severe cam deformity (A, B and C models) were obtained and used to construct 3D dry bone models. A 3D surgical plan was made in custom written software. Each 3D plan was imported into the Acrobot Sculptor robot and bone resection was carried out. In total, 42 femoral models were sculpted (14/subset), ...
Robust ultrathin oxynitride dielectrics by NH3 nitridation and N/sub 2/O RTA treatment (2000)

In this paper, a method to grow robust ultrathin (E/sub OT/=28 /spl Aring/) oxynitride film with effective dielectric constant of 5.7 is proposed. Samples, nitridized by NH/sub 3/ with additional N/sub 2/O annealing, show excellent electrical properties in terms of very low bulk trap density, low trap generation rate, and high endurance in stressing. This novel dielectric appears to be very promising for future ULSI devices.
Structural foundations of optogenetics: Determinants of channelrhodopsin ion selectivity (2015)

The structure-guided design of chloride-conducting channelrhodopsins has illuminated mechanisms underlying ion selectivity of this remarkable family of light-activated ion channels. The first generation of chloride-conducting channelrhodopsins, guided in part by development of a structure-informed electrostatic model for pore selectivity, included both the introduction of amino acids with positively charged side chains into the ion conduction pathway and the removal of residues hypothesized to support negatively charged binding sites for cations. Engineered channels indeed became chloride selective, reversing near -65 mV and enabling a new kind of optogenetic inhibition; however, these first-generation chloride-conducting channels displayed small photocurrents and were not tested for optogenetic inhibition of behavior. Here we report the validation and further development of the channelrhodopsin pore model via crystal structure-guided engineering of next-generation light-activated chloride channels (iC++) and a bistable variant (SwiChR++) with net photocurrents increased more than 15-fold under physiological conditions, reversal potential further decreased by another ∼ 15 mV, inhibition of spiking faithfully tracking chloride gradients and intrinsic cell properties, strong expression in vivo, and the initial microbial opsin channel-inhibitor-based control of freely moving behavior. We further show that inhibition by light-gated chloride channels is mediated mainly by shunting effects, which exert optogenetic control much more efficiently than the hyperpolarization induced by light-activated chloride pumps. The design and functional features of these next-generation chloride-conducting channelrhodopsins provide both chronic and acute timescale tools for reversible optogenetic inhibition, confirm fundamental predictions of the ion selectivity model, and further elucidate electrostatic and steric structure-function relationships of the light-gated pore.
Near-Common Zeros in Blind Identification of Simo Acoustic Systems (2008)

The common zeros problem for Blind System Identification (BSI) has been well known to degrade the performance of classic BSI algorithms and therefore limits performance of subsequent speech dereverberation. Recently, we have shown that multichannel systems cannot be well identified if near-common zeros are present. In this work, we further study the near-common zeros problem using channel diversity measure. We then investigate the use of forced spectral diversity (FSD) based on a combination of spectral shaping filters and effective channel undermodelling. Simulation results show the effectiveness of the proposed approach.
A Low-Power High-Performance Current-Mode (2001)

This paper presents a new approach for energy re- duction and speed improvement of multiport SRAMs. The key idea is to use current-mode for both read and write operations. To toggle a memory cell, a very small voltage swing is first created on the high-capacitive bit lines. This voltage is then translated into a dif- ferential current being injected into the cell, which in turn allows complementary potential to be developed on the cell nodes. As com- pared to the conventional write approach, spice simulations using a 0.35- m CMOS process have shown 2.8 to 9.9 in energy sav- ings and 1.02 to 6.36 reduction in delay, for memory sizes of 32 to 1 K words. We also present a current-mode sense-amplifier that operates in a similar fashion as the write circuit. The design and implementation of a pipelined 32 64 three-port register file uti- lizing the proposed technique is described. Measurements of the register file chip have confirmed the feasibility of the approach.
Further search for supersymmetry ats=7  TeVin final states with jets, missing transverse momentum, and isolated leptons with the ATLAS detector (2012)

This work presents a new inclusive search for supersymmetry (SUSY) by the ATLAS experiment at the LHC in proton-proton collisions at a center-of-mass energy $\sqrt{s}=7\text{ }\text{ }\mathrm{TeV}$ in final states with jets, missing transverse momentum and one or more isolated electrons and/or muons. The search is based on data from the full 2011 data-taking period, corresponding to an integrated luminosity of $4.7\text{ }\text{ }{\mathrm{fb}}^{\ensuremath{-}1}$. Single-lepton and multilepton channels are treated together in one analysis. An increase in sensitivity is obtained by simultaneously fitting the number of events in statistically independent signal regions, and the shapes of distributions within those regions. A dedicated signal region is introduced to be sensitive to decay cascades of SUSY particles with small mass differences (``compressed SUSY''). Background uncertainties are constrained by fitting to the jet-multiplicity distribution in background control regions. Observations are consistent with Standard Model expectations, and limits are set or extended on a number of SUSY models.
Reply to “Comment on ‘Realization of a bipolar atomic Šolc filter in the cavity-QED microlaser’ ” (2011)

In this reply to the Comment by Bouchene et al. [Phys. Rev. A 84, 037801 (2011)], we show that our experiment [Phys. Rev. A 81, 053824 (2010)] was a legitimate demonstration of the atomic $\stackrel{\ifmmode \check{}\else \v{}\fi{}}{\text{S}}$olc filter for the range of parameters that we have studied. The more detailed theoretical framework presented in the Comment and the interpretation of its outcome in terms of nonadiabatic jump are only necessary for larger field intensities.
Characteristics of Shear Bands and Fracture Surfaces of Zr<SUB>65</SUB>Al<SUB>7.5</SUB>Ni<SUB>10</SUB>Pd<SUB>17.5</SUB> Bulk Metallic Glass (2005)

In this work, the characteristics of shear bands and fracture surfaces of Zr65Al7.5Ni10Pd17.5 bulk metallic glass fractured by a tensile test was investigated. Zr65Al7.5Ni10Pd17.5 bulk metallic glass shows a yield stress of approximately 1.3 GPa, a fracture stress of approximately 1.5 GPa and a tensile plastic strain of 0.1–0.2% irrespective of the applied strain. Wavy, meandering shear bands were observed in the relatively wide area of specimen surfaces around the point of failure, and typical vein patterns were observed on the fracture surfaces. Shear bands and fracture surfaces were further examined by confocal microscopy to obtain more precise information on their roughness. On the other hand, evidence of viscous flow due to crack propagation was also obtained around the edge at the point of failure on specimen surfaces by confocal microscopy. The deformability of Zr65Al7.5Ni10Pd17.5 bulk metallic glass is discussed on the basis of the obtained results.
Roadmap for enhanced languages and methods to aid verification (2006)

This roadmap describes ways that researchers in four areas---specification languages, program generation, correctness by construction, and programming languages---might help further the goal of verified software. It also describes what advances the "verified software" grand challenge might anticipate or demand from work in these areas. That is, the roadmap is intended to help foster collaboration between the grand challenge and these research areas.A common goal for research in these areas is to establish language designs and tool architectures that would allow multiple annotations and tools to be used on a single program. In the long term, researchers could try to unify these annotations and integrate such tools.