gebhart/patrepeval huggingface dataset:
Single-crystal polarized electronic absorption spectra and the ligand field interpretation of the bonding of the trichloro(trimethylamine)platinate ion (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSingle-crystal polarized electronic absorption spectra and the ligand field interpretation of the bonding of the trichloro(trimethylamine)platinate ionTsu Hsin Chang and Jeffrey I. ZinkCite this: Inorg. Chem. 1985, 24, 26, 4499–4503Publication Date (Print):December 1, 1985Publication History Published online1 May 2002Published inissue 1 December 1985https://doi.org/10.1021/ic00220a016RIGHTS & PERMISSIONSArticle Views50Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (660 KB) Get e-Alerts Get e-Alerts
Modulated model predictive control (M<sup>2</sup>PC) with fixed switching frequency for an NPC converter (2015)

Advances in power electronic converters technology along with the wide range of applications require sophisticated digital control schemes. In the recent years Finite Control Set Model Predictive Control (FCS-MPC) has been successfully proposed as an alternative to the traditional control techniques, due to its fast dynamic response, easy inclusion of nonlinearities and constraints in the control algorithm and the ability of incorporate several control requirements in one cost function. However, FCS-MPC is characterized by a variable switching frequency which can cause a degradation in system performance, or demand higher output filtering. In this paper a Modulated Model Predictive Control (M <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> PC) strategy is proposed for constant switching frequency operation and verified with a neutral-point-clamped (NPC) converter for load current regulation and DC-link capacitor voltages balancing. The aim of this control technique is to obtain a modulated waveform at the output of the converter, whilst maintaining all the desired characteristics of FCS-MPC. The feasibility of this strategy is evaluated using simulation and compared to the classical FCS-MPC strategy.
Using oligonucleotide probe arrays to access genetic diversity (1999)

As the Human Genome Project and related efforts identify and determine the DNA sequences of human genes, it is important that highly reliable and efficient mechanisms are found to access individual genetic variation. It is only through a greater understanding of genetic diversity that the true benefit of the Human Genome Project will be realized. One approach, hybridization to high-density arrays of oligonucleotides, is a fast and effective means of accessing this genetic variation. Light-directed chemical synthesis has been used to generate miniaturized, high-density arrays of oligonucleotide probes. Application-specific oligonucleotide probe array designs have been developed for the rapid screening of characterized genes. Dedicated instrumentation and software have been developed for array hybridization, fluorescence detection and data acquisition and analysis. In a specific and challenging application, oligonucleotide probe arrays have been used to screen the reverse transcriptase and protease genes of the highly polymorphic HIV-1 genome to explore genetic diversity and detect mutations conferring resistance to antiviral drugs. Results from this application strongly suggest that oligonucleotide probe arrays will be a powerful tool for rapid investigations in sequence checking, pathogen detection, expression monitoring and DNA molecular recognition.
An oomycete effector subverts host vesicle trafficking to channel starvation-induced autophagy to the pathogen interface (2021)

Eukaryotic cells deploy autophagy to eliminate invading microbes. In turn, pathogens have evolved effector proteins to counteract antimicrobial autophagy. How adapted pathogens co-opt autophagy for their own benefit is poorly understood. The Irish famine pathogen <i>Phytophthora infestans</i> secretes the effector protein PexRD54 that selectively activates an unknown plant autophagy pathway that antagonizes antimicrobial autophagy at the pathogen interface. Here, we show that PexRD54 induces autophagosome formation by bridging vesicles decorated by the small GTPase Rab8a with autophagic compartments labeled by the core autophagy protein ATG8CL. Rab8a is required for pathogen-triggered and starvation-induced but not antimicrobial autophagy, revealing specific trafficking pathways underpin selective autophagy. By subverting Rab8a-mediated vesicle trafficking, PexRD54 utilizes lipid droplets to facilitate biogenesis of autophagosomes diverted to pathogen feeding sites. Altogether, we show that PexRD54 mimics starvation-induced autophagy to subvert endomembrane trafficking at the host-pathogen interface, revealing how effectors bridge distinct host compartments to expedite colonization.
Optimization for sag-free simulations (2011)

A common problem during the first few seconds of a cloth, hair, or flesh simulation is that the mesh sags under gravity, which can undo the work of hours of careful modeling. The typical response of increasing the stiffness of the mesh is unsatisfactory as it increases the computational cost of simulation and adversely impacts the quality of the resulting motion. Modelers are accustomed to creating geometry as it is found in the real world, which already includes the effect of gravity. We propose a fast and effective approach for optimizing parameters such as spring rest lengths so that the artistically modeled shape represents the equilibrium after the mesh has settled under gravity. This eliminates sagging, preserves the quality of motion, and is intuitive for the artists.
Novel technetium-99m-labeled platelet GPIIb/llla receptor antagonists as potential imaging agents for venous and arterial thrombosis (1998)

Objectives Either venous or arterial thrombosis is a potentially life-threatening event and existing diagnostic modalities are inadequate to diagnose and to determine the morphology of the evolving thrombus. Thus development of a noninvasive imaging agent that can detect clot location remains a critical and unmet need in nuclear diagnostic medicine. The present study was undertaken to determine the potential of platelet GPIIb/IIIa receptors compared with direct thrombin inhibitors, in the detection of venous and arterial clots. Methods Initially, the validity of exploiting the degree and extent of specific uptake and retention of a potent GPIIb/IIIa receptor antagonist in venous and in arterial thrombus was confirmed in vitro in artificially created arterial- or venous-type clots, using the radiolabeled antagonist, 3H-DMP728. This was followed by comparing the in-vivo clot/blood distribution of various technetium-99m (99mTc)-labeled, DMP728-derived, GPIIb/IIIa receptor antagonists and of thrombin inhibitors, over time, in mixed arterial/venous or venous clots in arteriovenous shunt and in venous clot models in dogs. In addition, we performed noninvasive single-photon emission tomographic imaging of the venous clot in a deep vein thrombosis model in dogs. Results Our data confirmed that potency for the platelet GPIIb/IIIa receptors was maintained after radiolabeling of the parent active GPIIb/IIIa receptor antagonists. DMP728 demonstrated a relatively greater affinity for activated than for unactivated human platelets, which might be essential for attaining an optimal thrombus/blood (target/background) distribution ratio and the optimal detection of small clots (i.e. greater sensitivity). Conclusions These data suggest a potential utility of 99mTc-GPIIb/IIIa receptor antagonists, but not of direct thrombin inhibitors, in the diagnosis of venous clots in deep vein thrombosis, pulmonary embolism and arterial thromboembolic disorders including stroke and coronary and peripheral artery thrombotic disorders. Coronary Artery Dis 9:131-141 ©1988 Lippincott-Raven Publishers.
CRISPR/Cas9 microinjection in oocytes disables pancreas development in sheep (2017)

One of the ultimate goals of regenerative medicine is the generation of patient-specific organs from pluripotent stem cells (PSCs). Sheep are potential hosts for growing human organs through the technique of blastocyst complementation. We report here the creation of pancreatogenesis-disabled sheep by oocyte microinjection of CRISPR/Cas9 targeting PDX1, a critical gene for pancreas development. We compared the efficiency of target mutations after microinjecting the CRISPR/Cas9 system in metaphase II (MII) oocytes and zygote stage embryos. MII oocyte microinjection reduced lysis, improved blastocyst rate, increased the number of targeted bi-allelic mutations, and resulted in similar degree of mosaicism when compared to zygote microinjection. While the use of a single sgRNA was efficient at inducing mutated fetuses, the lack of complete gene inactivation resulted in animals with an intact pancreas. When using a dual sgRNA system, we achieved complete PDX1 disruption. This PDX1<sup>-/-</sup> fetus lacked a pancreas and provides the basis for the production of gene-edited sheep as a host for interspecies organ generation. In the future, combining gene editing with CRISPR/Cas9 and PSCs complementation could result in a powerful approach for human organ generation.
Hugoniot Measurements of High Pressure Phase Stability of Titanium-Silicon Carbide (Ti3SiC2) (2004)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation J. L. Jordan, T. Sekine, T. Kobayashi, X. Li, N. N. Thadhani, T. El‐Raghy, M. W. Barsoum; Hugoniot Measurements of High Pressure Phase Stability of Titanium‐Silicon Carbide (Ti3SiC2). AIP Conf. Proc. 20 July 2004; 706 (1): 77–80. https://doi.org/10.1063/1.1780188 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Photochemistry of Azides: The Azide/Nitrene Interface (2009)

This chapter contains sections titled: Introduction Photochemistry of Hydrazoic Acid (HN3) Photochemistry of Alkyl Azides Photochemistry of Vinyl Azides Photochemistry of Carbonyl Azides and Azide Esters Photochemistry of Phenyl Azide and Its Simple Derivatives Conclusion Acknowledgments References
Bounce-Flash Lidar (2022)

We introduce a new mode of lidar imaging called \emph{bounce-flash lidar}. In bounce-flash lidar, most surfaces in the scene are illuminated indirectly by light that has scattered off of a nearby surface. We exploit the fact that a laser spot projected onto a diffusely reflecting surface can be treated as a point source. We use single-bounce time-of-flight measurements to determine the position of this point source, and then use a bi-static range equation to compute the position of \emph{indirectly} illuminated points from \emph{two-bounce} time-of-flight measurements. We propose and then experimentally demonstrate simple methods for estimating scene range and reflectance using the time-of-flight and intensity of one- and two-bounce returns. We also demonstrate two important advantages of using bounce-flash illumination in lidar imaging. First, two-bounce light carries information that the single-bounce returns do not. In particular, \emph{cast shadows} can be used to estimate the geometry of occluded surfaces. Second, bounce-flash lidar systems enable strategic positioning of the illumination source. This source can be placed arbitrarily close to a target of interest, or positioned to enable observation of specular surfaces that would otherwise reflect very little light back towards the receiver.
A Plastic–Crystal Electrolyte Interphase for All‐Solid‐State Sodium Batteries (2017)

Abstract The development of all‐solid‐state rechargeable batteries is plagued by a large interfacial resistance between a solid cathode and a solid electrolyte that increases with each charge–discharge cycle. The introduction of a plastic–crystal electrolyte interphase between a solid electrolyte and solid cathode particles reduces the interfacial resistance, increases the cycle life, and allows a high rate performance. Comparison of solid‐state sodium cells with 1) solid electrolyte Na 3 Zr 2 (Si 2 PO 4 ) particles versus 2) plastic–crystal electrolyte in the cathode composites shows that the former suffers from a huge irreversible capacity loss on cycling whereas the latter exhibits a dramatically improved electrochemical performance with retention of capacity for over 100 cycles and cycling at 5 C rate. The application of a plastic–crystal electrolyte interphase between a solid electrolyte and a solid cathode may be extended to other all‐solid‐state battery cells.
Transforming artifact to signal: A wavelet-based algorithm for quantifying neonatal movement (2014)

In neonatal research, physiological signals are often degraded by an artifact generated by movement of the infant. Portions of these movement embedded signals are commonly excluded in the analysis of the relevant physiological signal. However, movement may be a significant marker of physiological development of the infant. Here we present results from a wavelet-based algorithm that quantifies neonatal movement, using recordings from the pulse plethysmograph. We suggest that movement-induced artifactual signal can yield important physiological information regarding neonatal physiology.
Impact of the COVID‐19 pandemic on surgery for benign diseases in gynecology: A nationwide survey by the Japan Society of Obstetrics and Gynecology (2022)

The number of surgeries for benign gynecological diseases decreased by 8.5% in 2020 compared to that in 2019. This value is among the lowest in the world.
Pixelated Resonant Subwavelength Grating Filters for Greenhouse Gas Monitoring. (2016)

Abstract not provided.
Regulatory elements involved in the liver-specific expression of the mouse MHC class I Q10 gene: characterization of a new TATA-binding factor (1990)

The murine MHC genes code for the classical H-2K, D, and L transplantation antigens, and for other class I-like proteins called Qa and TIa molecules. Most of the latter have a restricted tissue distribution whereas classical transplantation antigens are virtually expressed by all somatic cells of the adult organism. Q10 is a Qa region gene, which was found to be expressed in liver and yolk sac, a regulatory pattern more evocative of the expression of a large set of serum proteins secreted by the liver than of a classical class I antigen. First, we have characterized several regions in the promoter of Q10 which bind factors present in liver nuclear extracts. Our most striking observation is that one of these factors, which we named TA-f, binds in the TATA box region of Q10 and Kb and displays tissue-specific expression, in that we found the activity only in liver and kidney. Secondly, we have performed a comparative analysis of the 5' upstream sequences of Q10 with those of H-2Kb, Ld, and other Qa genes. We have shown that most of the regulatory elements involved in the ubiquitous expression of H-2Kb are punctually altered and not functional in Q10. Similarly, most of the binding sequences for liver factors in the Q10 promoter, except the TA region, do not exist in the other H-2 class I genes which, however, have conserved most of the functional regions defined in H-2Kb and Ld. These results suggest that the tissue-specific expression of Q10 is associated with both alteration of the sequences conferring ubiquitous expression to other class I genes and/or creation of new sequences able to bind liver-specific regulatory factors. However, our observations also suggest that a unique sequence, the TATA box, may confer differential regulation in different tissues, since it binds a factor whose expression is restricted to the liver and kidney.
Kitaev's Z_d-Codes Threshold Estimates (2013)

We study the quantum error correction threshold of Kitaev's toric code over the group Z_d subject to a generalized bit-flip noise. This problem requires novel decoding techniques, and for this purpose we generalize the renormalization group method we previously introduced in [Duclos-Cianci/Poulin,arXiv:0911.0581,2009; Duclos-Cianci/Poulin,ITW'10,2010] for Z_2 topological codes.
Defining 2 Components of Shoulder Imbalance (2012)

Our analysis suggests that there are 2 distinct regions (lateral and medial) of shoulder height asymmetry. Medial differences reflected in trapezial prominence relate to deformity created by upward tilted proximal ribs and T1 tilt. Lateral differences in shoulder symmetry as reflected in the clavicle angle correlate weakly with radiographical measures. This suggests that correction of trapezial prominence may be more predictable compared with clavicle angulation after scoliosis surgery.
Neurokinin B Signaling in the Female Rat: a Novel Link Between Stress and Reproduction (2014)

Acute systemic stress disrupts reproductive function by inhibiting pulsatile gonadotropin secretion. The underlying mechanism involves stress-induced suppression of the GnRH pulse generator, the functional unit of which is considered to be the hypothalamic arcuate nucleus kisspeptin/neurokinin B/dynorphin A neurons. Agonists of the neurokinin B (NKB) receptor (NK3R) have been shown to suppress the GnRH pulse generator, in a dynorphin A (Dyn)-dependent fashion, under hypoestrogenic conditions, and Dyn has been well documented to mediate several stress-related central regulatory functions. We hypothesized that the NKB/Dyn signaling cascade is required for stress-induced suppression of the GnRH pulse generator. To investigate this ovariectomized rats, iv administered with Escherichia coli lipopolysaccharide (LPS) following intracerebroventricular pretreatment with NK3R or κ-opioid receptor (Dyn receptor) antagonists, were subjected to frequent blood sampling for hormone analysis. Antagonism of NK3R, but not κ-opioid receptor, blocked the suppressive effect of LPS challenge on LH pulse frequency. Neither antagonist affected LPS-induced corticosterone secretion. Hypothalamic arcuate nucleus NKB neurons project to the paraventricular nucleus, the major hypothalamic source of the stress-related neuropeptides CRH and arginine vasopressin (AVP), which have been implicated in the stress-induced suppression of the hypothalamic-pituitary-gonadal axis. A separate group of ovariectomized rats was, therefore, used to address the potential involvement of central CRH and/or AVP signaling in the suppression of LH pulsatility induced by intracerebroventricular administration of a selective NK3R agonist, senktide. Neither AVP nor CRH receptor antagonists affected the senktide-induced suppression of the LH pulse; however, antagonism of type 2 CRH receptors attenuated the accompanying elevation of corticosterone levels. These data indicate that the suppression of the GnRH pulse generator by acute systemic stress requires hypothalamic NKB/NK3R signaling and that any involvement of CRH therewith is functionally upstream of NKB.
Interleukin-6 is an Autocrine Growth Factor for Murine Lung Fibroblast Subsets (1994)

Interleukin-6 (IL-6) is a pleiotropic cytokine having several functions, including the regulation of immunologic and inflammatory responses. It is produced by many cell types, including lymphocytes, macrophages, and fibroblasts, and is believed to play a major role in pulmonary fibrosis, a condition resulting from expansion of the fibroblast compartment and the accumulation of extracellular matrices secreted primarily by fibroblasts. Production of IL-6 by lung fibroblasts has been well documented; however, it was not known whether all murine lung fibroblasts secreted IL-6 or only subsets thereof. Previous studies in our laboratory have shown that murine lung fibroblasts can be divided into subpopulations based on Thy 1 expression. These subpopulations, Thy 1+ and Thy 1-, differ in morphology, expression of surface markers, and function. IL-6 mRNA was detected in both Thy 1+ and Thy 1- murine fibroblasts and clones using reverse transcriptase polymerase chain reaction (RT-PCR). Interestingly, semi-quantitative RT-PCR and Northern blot analysis demonstrated that IL-6 mRNA was down-regulated in confluent fibroblast cultures versus cultures in log phase growth. Also, IL-6 activity was detected in the supernatants of murine lung fibroblast lines and clones using an IL-6-dependent hybridoma assay. Hybridoma proliferation was inhibited by the addition of a neutralizing anti-mouse IL-6 antibody, indicating that the activity was indeed due to IL-6. The lung fibroblasts expressed IL-6 receptors on their surface as determined by flow cytometry using a rat anti-mouse IL-6 receptor antibody (15A7).(ABSTRACT TRUNCATED AT 250 WORDS)
Origins of concentric cylinders viscometry (2005)

The history of the concentric cylinders apparatus for measuring the shear viscosity of liquids, and its attribution to Maurice Couette, have been explored. Examination of the Nineteenth Century literature has revealed that the concept goes back to Stokes and later Margules, the design and execution of the apparatus, apparently independently, to Perry, Couette, Mallock, and Schwedoff. Mallock’s and Schwedoff’s measurements were the most accurate and were within 1% of the viscosities derived from Poiseuille’s measurements on the basis of no slip at the tube walls and cylinder surfaces. Measurement of fluid viscosity was closely linked to the adoption of the no-slip boundary condition at solid-fluid interfaces.
Regions of the CD4 molecule not involved in virus binding or syncytia formation are required for HIV-1 infection of lymphocytes (1992)

Cell surface-expressed CD4 binds to the envelope glycoprotein of HIV-1 and mediates syncytia formation through interacting with membrane expressed HIV-1 gp120. Further possible roles of the CD4 molecule in the process of cell infection by HIV-1 remain poorly understood. In our study we describe two mAb that recognize the V3/V4 domain of the CD4 molecule. Although these mAb do not inhibit gp120-CD4 binding or HIV-1-induced syncytia formation, they inhibit HIV-1 infection of human PBL. These findings suggest that discrete, definable domains of the CD4 molecule may be involved in interactions after HIV-1 envelope binding that lead to virus entry into the cell.
Supplementary Figure 1 from Myeloid Cells Obtained from the Blood but Not from the Tumor Can Suppress T-cell Proliferation in Patients with Melanoma (2023)

&lt;p&gt;PDF file, 50K, The relative frequency of leucocytes in melanoma metastasis (n=14) was determined and represented as a percent of all the live cells in the tumor (left panel) and absolute counts/g of tumor (right panel). 'Others' includes tumor cells, fibroblasts and other cell types that were not separately studied.&lt;/p&gt;