gebhart/patrepeval huggingface dataset:
Envelope-Tracking Supply Modulator with Trellis Search-Based Switching and 160MHz Capability (2021)

Envelope tracking (ET) is in wide use to raise the efficiencies of PAs. We report on the realization of a new envelope-tracking supply modulator (ETSM). A hybrid amplifier (HA) is commonly used, which, in effect, partitions the envelope bandwidth into a low and high subband. An efficient switching buck converter tracks the low band that contains most of the load current. In parallel, an op amp with a Class-AB output stage supplies the current in the high band. Feedback on the op amp servos the total current to the envelope waveform extracted from the baseband modulator (Fig. 1).
Micro-optics and Megapixels (2006)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text David J. Brady, "Micro-optics and Megapixels," Optics & Photonics News 17(11), 24-29 (2006) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Immunogenicity in Mamu-A*01 rhesus macaques of a CCR5-tropic human immunodeficiency virus type 1 envelope from the primary isolate (Bx08) after synthetic DNA prime and recombinant adenovirus 5 boost (2003)

Envelopes of primary R5-tropic human immunodeficiency virus type 1 (HIV-1) isolates may be particularly relevant for vaccine purposes and should be evaluated for immunogenicity in animals including macaques before carrying out human vaccine trials. In the present study, the immunogenicities of synthetic HIV-1 env DNA vaccines, which had been derived from the early primary isolate Bx08 and contain humanized codons, were evaluated in mice, guinea pigs and rhesus macaques. Neutralization sensitivity of the HIV-1(Bx08) isolate was found to resemble that of other primary isolate prototypes. Immunogenicity of gp120 delivered as codon-optimized DNA vaccine was comparable to that of recombinant gp120 protein plus adjuvant in mice. Similarly, DNA vaccination of guinea pigs with synthetic gp140(Bx08) and gp150(Bx08) DNA induced a strong antibody response independent of the gene construct and DNA immunization route. Mamu-A*01 rhesus macaques were DNA vaccinated with synthetic gp150(Bx08) or gp140(Bx08) DNA and boosted with a replication-deficient recombinant human adenovirus type 5 expressing a synthetic gp120(Bx08) gene. DNA-vaccinated rhesus macaques developed specific CD8+ T lymphocyte responses and anti-rgp120(IIIb) antibody responses. Both the humoral and cellular responses were significantly improved following intramuscular boosting with the recombinant adenovirus. The demonstrated humoral and cellular immunogenicities of these HIV Bx08 Env vaccines in non-human primates encourages their further development as one component in candidate HIV vaccines for humans.
Conflict Interest disclosure from Efficacy of Anti-mesothelin Immunotoxin RG7787 plus Nab-Paclitaxel against Mesothelioma Patient–Derived Xenografts and Mesothelin as a Biomarker of Tumor Response (2023)

&lt;p&gt;Conflict of Interest Form&lt;/p&gt;
First recorded outbreak of yellow fever in Kenya, 1992-1993. I. Epidemiologic investigations. (1998)

Outbreaks of yellow fever (YF) have never been recorded in Kenya. However, in September 1992, cases of hemorrhagic fever (HF) were reported in the Kerio Valley to the Kenya Ministry of Health. Early in 1993, the disease was confirmed as YF and a mass vaccination campaign was initiated. Cases of suspected YF were identified through medical record review and hospital-based disease surveillance by using a clinical case definition. Case-patients were confirmed serologically and virologically. We documented 55 persons with HF from three districts of the Rift Valley Province in the period of September 10, 1992 through March 11, 1993 (attack rate = 27.4/100,000 population). Twenty-six (47%) of the 55 persons had serologic evidence of recent YF infection, and three of these persons were also confirmed by YF virus isolation. No serum was available from the other 29 HF cases. In addition, YF virus was isolated from a person from the epidemic area who had a nonspecific febrile illness but did not meet the case definition. Five patients with confirmed cases of YF died, a case-fatality rate of 19%. Women with confirmed cases of YF were 10.9 times more likely to die than men (P = 0.010, by Fisher's exact test). Of the 26 patients with serologic or virologic evidence of YF, and for whom definite age was known, 21 (81%) were between 10 and 39 years of age, and 19 (73%) were males. All patients with confirmed YF infection lived in rural areas. There was only one instance of multiple cases within a single family, and this was associated with bush-clearing activity. This was the first documented outbreak of YF in Kenya, a classic example of a sylvatic transmission cycle. Surveillance in rural and urban areas outside the vaccination area should be intensified.
[Follicular lymphoma accompanied by paraneoplastic pemphigus and bronchiolitis obliterans: a case report]. (2019)

A 54-year-old female complained of oral erosion. A flaccid blister appeared on the trunk 2 months after the onset. The high titer of the anti-desmoglein 1 antibody in the absence of Nikolsky's sign led to the diagnosis of pemphigus vulgaris. The lymphadenopathy in the mesenteric and para-aortic regions indicated the possibility of paraneoplastic pemphigus. The steroid pulse therapy and therapeutic plasma exchange were ineffective. As CT-guided intraperitoneal lymph node biopsy revealed follicular lymphoma, R-CHOP therapy was performed. Although partial remission was attained accompanied by an improvement in the skin and mucosal findings after four courses of R-CHOP therapy, an occlusive ventilatory disturbance, possibly attributed to bronchiolitis obliterans, appeared 4 months after the treatment initiation. Although the treatment with tacrolimus was attempted, it was not feasible to be continued because of opportunistic infection, and the patient died 9 months after the onset of the skin lesion. Although specific anti-plakin antibodies were negative, this case was diagnosed as paraneoplastic pemphigus due to follicular lymphoma and complicated by obstructive bronchiolitis based on the clinical findings. The accumulation of similar cases is needed to establish effective treatment strategies.
Presence of a Mouse Embryonic Antigen on Human Spermatozoa (1974)

A cell-surface antigen common to mouse primitive teratocarcinoma cells, morulae, and spermatozoa and specified by the +(t12) allele at the T-locus of the mouse has been shown by serological methods to be present on the surface of human spermatozoa, but not of human lymphocytes, fibroblasts, or erythrocytes.
SIMULATION OF A CIVIL INTEGRITY NETWORK (1992)

This paper describes simulations of the GPS and Glonass integrity channel (GIC), which will be used to broadcast GPS and Glonass health information to mo- bile users. The simulator includes models for: the signals from the GPS, GIonass and geostationary satellites; the user equipment; the integrity monitors; the integrity network con- trol sites; and the communication links between the monitors and control sites. The paper will describe the simulation of a worldwide integrity network with coverage, and the simulation of a depth two network for North America.
Hotspot Thermal Management With Flow Boiling of Refrigerant in Ultrasmall Microgaps (2016)

As integration levels increase in next generation electronics, high power density devices become more susceptible to hotspot formation, which often imposes a thermal limitation on performance. Flow boiling of R134a in two microgap heat sink configurations was investigated as a solution for hotspot thermal management: a bare microgap and inline micro-pin fin populated microgap, both with 10 μm gap height, were tested in terms of their ability to dissipate heat fluxes approaching 5 kW/cm2 at the heat source. Additional parameters investigated include mass fluxes up to 3000 kg/m2 s at inlet pressures up to 1.5 MPa and exit qualities approaching unity. The microgap testbeds investigated consist of a silicon layer which is heated from the bottom using resistive heaters and capped with glass to enable visual observation of two-phase flow regimes. Wall temperature, device thermal resistance, and pressure drop results are presented and mapped to the dominant flow regimes that were observed in the microgap.
Effects of Ligand Structure on Reactive Vapor−Liquid Distribution Ratio and Selectivity for C6-Olefin Isomers (2005)

Vapor−liquid equilibrium experiments are performed to evaluate the suitability of π-complexing silver of various phosphoric and sulfonic acids for application as functionalized solvents in Reactive Extractive Distillation to separate 1-hexene from other C6-olefin isomers. The effect of solvent structure is investigated by testing five different ligands, di (2-ethylhexyl) phosphoric acid (D2EHPA), di (butyl) phosphoric acid (DBPA), mono (2-ethylhexyl) phosphoric acid (MEHPA), di (nonyl) naphthalene sulfonic acid (DNNSA), and dodecyl benzene sulfonic acid (DBSA), for a variety of C6-olefin isomers (1-hexene, 2-methyl-1-pentene, n-hexane, 1,5-hexadiene, trans-2-hexene). The introduction of silver in the solvent increases the solvent selectivity for 1-hexene. At equal silver concentration the ligand size does not influence the selectivity of chemically similar components (1-hexene/2-methyl-1-pentene) but increases that of chemically different components (1-hexene/n-hexane). A lower pressure, a higher silver concentration, or higher solvent-to-feed (S/F) ratio are beneficial for the 1-hexene selectivity. The highest selectivity is obtained for Ag−DBPA (20 wt % Ag, S/F-ratio of 3): 1.23 for 2-methyl-1-pentene and 1.42 for n-hexane, relative to 1.04−1.06 for unreactive solvents.
Solid‐phase synthesis: a paradigm shift (2003)

A personal review by the first graduate student of Professor R. Bruce Merrifield of the evolution of solid-phase synthesis and its acceptance by various subsets of the chemistry community. Solid-phase synthesis, as currently practised in the synthesis of biopolymers, combinatorial solid-phase organic chemistry, synthesis of natural products, catalyst selection, chemical ligation and materials development, has proven a paradigm shift for the chemistry community.
Role of Phosphorylation and Basic Residues in the Catalytic Domain of Cytosolic Phospholipase A2α in Regulating Interfacial Kinetics and Binding and Cellular Function (2009)

Group IVA cytosolic phospholipase A(2) (cPLA(2)alpha) is regulated by phosphorylation and calcium-induced translocation to membranes. Immortalized mouse lung fibroblasts lacking endogenous cPLA(2)alpha (IMLF(-/-)) were reconstituted with wild type and cPLA(2)alpha mutants to investigate how calcium, phosphorylation, and the putative phosphatidylinositol 4,5-bisphosphate (PIP(2)) binding site regulate translocation and arachidonic acid (AA) release. Agonists that elicit distinct modes of calcium mobilization were used. Serum induced cPLA(2)alpha translocation to Golgi within seconds that temporally paralleled the initial calcium transient. However, the subsequent influx of extracellular calcium was essential for stable binding of cPLA(2)alpha to Golgi and AA release. In contrast, phorbol 12-myristate 13-acetate induced low amplitude calcium oscillations, slower translocation of cPLA(2)alpha to Golgi, and much less AA release, which were blocked by chelating extracellular calcium. AA release from IMLF(-/-) expressing phosphorylation site (S505A) and PIP(2) binding site (K488N/K543N/K544N) mutants was partially reduced compared with cells expressing wild type cPLA(2)alpha, but calcium-induced translocation was not impaired. Consistent with these results, Ser-505 phosphorylation did not change the calcium requirement for interfacial binding and catalysis in vitro but increased activity by 2-fold. Mutations in basic residues in the catalytic domain of cPLA(2)alpha reduced activation by PIP(2) but did not affect the concentration of calcium required for interfacial binding or phospholipid hydrolysis. The results demonstrate that Ser-505 phosphorylation and basic residues in the catalytic domain principally act to regulate cPLA(2)alpha hydrolytic activity.
Optical free-induction decay in fractal clusters (1994)

It is shown that optical free-induction decay (OFID) in fractals is governed by a power-law time dependence. The scale invariance of the OFID in the time domain results from the self-similar distribution of the dipolar eigenmodes in fractals.
Synthesis and Luminescence Properties of Orange–Red‐Emitting M 2 Si 5 N 8 :Eu 2+ (M=Ca, Sr, Ba) Light‐Emitting Diode Conversion Phosphors by a Simple Nitridation of MSi 2 (2009)

Eu 2+ ‐doped M 2 Si 5 N 8 (M=Ca, Sr, Ba) orange–red phosphors were successfully prepared by a simple, direct, and efficient solid‐state reaction using air‐stable MSi 2 , Eu 2 O 3 , and α‐Si 3 N 4 as the starting materials under N 2 –H 2 (5%) atmosphere. The influence of the type of the alkaline‐earth ion on the phase structure and luminescence properties has been investigated. The results show that the synthesized powders have a single‐phase crystal structure of M 2 Si 5 N 8 for M=Ca, Sr, and a little amount of BaSi 7 N 10 impurity phase for M=Ba. Under the blue light excitation, M 2 Si 5 N 8 :Eu 2+ shows a typical broad band emission of Eu 2+ ranging from orange to red (585–620 nm) depending on the type of M ion. The emission intensity, conversion efficiency, and thermal stability increase with the sequence of Ca&lt;Ba&lt;Sr, which suggests that Sr 2 Si 5 N 8 :Eu 2+ has the highest application potential as a red conversion phosphor for white light‐emitting diodes.
Bacterial biofilms of importance to medicine and bioterrorism: proteomic techniques to identify novel vaccine components and drug targets (2003)

Biofilms are highly ordered microbial communities enmeshed in a carefully sculpted matrix designed for survival of organisms either in multi- or mono-genus/species in a specific microniche. In human disease, biofilm infections are some of the most recalcitrant to treat. Even with rigorous antibiotic regimens, some biofilms, such as those within the thick airway mucus of cystic fibrosis (CF) patients, persist throughout the course of the disease process. In this editorial, discussion will cover the utility of using advanced proteomic techniques to help identify potential weaknesses in the already impressive defensive armamentarium of biofilm bacteria. Two biofilm systems will be discussed herein, one of which is that of Pseudomonas aeruginosa biofilms within CF airway biofilms. The other is referred to as persistent 'bioterrorist agent biofilms' in which Francisella tularensis can grow on surfaces where environmental amoeba can phagocytose them, allowing for growth of F. tularensis within the amoebae.
The real-time interactive 3-D-DVA for robust coronary MRA (2000)

A graphical user interface (GUI) has been developed which enables interactive feedback and control to the real-time diminishing variance algorithm (DVA). This interactivity allows the user to set scan parameters, view scan statistics, and view image updates during the course of the scan. In addition, the DVA has been extended to simultaneously reduce motion artifacts in three dimensions using three orthogonal navigators. Preliminary in vivo studies indicate that these improvements to the standard DVA allow for significantly improved consistency and robustness in eliminating respiratory motion artifacts from MR images, particularly when imaging the coronary arteries.
Tissue and Cell-Free DNA-Based Epigenomic Approaches for Cancer Detection (2019)

In this review we discuss the analytic validation of tissue and cell-free DNA-based epigenomic approaches for early cancer detection, diagnosis, and treatment monitoring and the clinical utility of candidate epigenetic alterations applied to colorectal, glioblastoma, breast, prostate, bladder, and lung cancer management.
Primary Granulocytic Sarcoma of the Face (2011)

Myeloid sarcoma is a tumor which consists of myeloblasts or immature myeloid cells. This tumor presents in the lymphoid organs, bone, skin, soft tissue, various mucosae and organs, and the central nervous system. Granulocytic sarcoma, an extramedullary acute myeloid leukemia, is also referred to as chloroma (GS) because of its greenish surface color. Granulocytic sarcoma is rare and difficult to diagnose. We can easily misdiagnose this tumor as lymphoma or sarcoma, especially when there is no evidence of hematologic disorders. Immunohistochemical studies are helpful in determining the correct diagnosis. Antibodies to myeloperoxidase, lysozyme, and chloroacetate esterase are used for the diagnosis of granulocytic sarcoma. In addition, detection of cell surface markers such as CD 33, CD 34, CD 68, CD 99, and HLA-DR may be useful. We describe a case of GS that presented with bluish nodules on the right cheek of a 54-year-old woman with immunohistochemical findings for correct diagnosis.
Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction (2017)

Diabetic nephropathy (DN) is a major cause of end-stage renal disease, and therapeutic options for preventing its progression are limited. To identify novel therapeutic strategies, we studied protective factors for DN using proteomics on glomeruli from individuals with extreme duration of diabetes (≥ 50 years) without DN and those with histologic signs of DN. Enzymes in the glycolytic, sorbitol, methylglyoxal and mitochondrial pathways were elevated in individuals without DN. In particular, pyruvate kinase M2 (PKM2) expression and activity were upregulated. Mechanistically, we showed that hyperglycemia and diabetes decreased PKM2 tetramer formation and activity by sulfenylation in mouse glomeruli and cultured podocytes. Pkm-knockdown immortalized mouse podocytes had higher levels of toxic glucose metabolites, mitochondrial dysfunction and apoptosis. Podocyte-specific Pkm2-knockout (KO) mice with diabetes developed worse albuminuria and glomerular pathology. Conversely, we found that pharmacological activation of PKM2 by a small-molecule PKM2 activator, TEPP-46, reversed hyperglycemia-induced elevation in toxic glucose metabolites and mitochondrial dysfunction, partially by increasing glycolytic flux and PGC-1α mRNA in cultured podocytes. In intervention studies using DBA2/J and Nos3 (eNos) KO mouse models of diabetes, TEPP-46 treatment reversed metabolic abnormalities, mitochondrial dysfunction and kidney pathology. Thus, PKM2 activation may protect against DN by increasing glucose metabolic flux, inhibiting the production of toxic glucose metabolites and inducing mitochondrial biogenesis to restore mitochondrial function.
Quantitative analysis of remedial approaches, costs, and time required to remediate dry cleaner sites (2011)

Abstract This article presents an analysis of remedial approaches, costs, and time required to remediate dry cleaner sites in the United States based on data compiled by the State Coalition for the Remediation of Dry Cleaners (SCRD). Trends in soil and groundwater remedy selection are identified and discussed. Median costs and the time required to remediate dry cleaner sites are presented. In addition, median costs and the duration of soil and groundwater remediation for the most widely used remedial approaches are reported. The analysis is intended to serve the needs of stakeholders, including responsible parties, consultants, regulators, and litigants, as well as real estate developers, banks, and other holders of portfolios of impacted dry cleaner sites by providing quantitative results useful for planning and transactional analysis. © 2011 Wiley Periodicals, Inc.
Strongly enhanced ultraviolet emission of an Au@SiO2/ZnO plasmonic hybrid nanostructure (2016)

We present the surface plasmon polariton (SPP)-enhanced ultraviolet (UV) emission of an Au@SiO2/ZnO hybrid nanostructure. We achieved approximately 20- and 8-fold enhancements of the UV-emitting intensities from Au-SPP coupled nanometre- and micrometre-scaled ZnO wires through an optimized 5 nm-thick SiO2 spacer compared to that obtained from bare ZnO on a Si substrate without SPP coupling. Cathodoluminescence measurements and simulations demonstrated that the plasmonic hybrid nanostructure enables the strong localization of the SPP field, resulting in significantly enhanced UV emission. This plasmonic structure paves the way to nanoscale UV-optical lasers and sensors.
Analysis and design principles for shear-mode piezoelectric energy harvesting with ZnO nanoribbons (2010)

A comprehensive theory addresses the potential for nanoscale energy harvesting with an array of vertically aligned zinc oxide (ZnO) nanoribbons. Through shear-mode piezoelectric coupling, the nanoribbons are capable of generating electricity from elastic deformations induced by sliding friction or mechanical vibration. In contrast to current ZnO nanowire generators, nanoribbons exhibit a unique combination of geometry and poling orientation that eliminates the need for a nanostructured cathode and allows electrodes to be permanently bonded to the array. The theory incorporates principles and design constraints from solid mechanics, electrostatics, piezoelectricity, vibration dynamics, circuit theory, and tribology. The accuracy of the approximate algebraic solutions is evaluated with finite element modeling. For geometries and operation modes of interest, the electrical power output and conversion ratio from mechanical power input are limited to ∼ 10 nW mm − 3 and 1000:1, respectively. While modest, such numbers provide a proper perspective on the potential for nanopiezoelectric energy harvesting.
NIR light-directing self-organized 3D photonic superstructures loaded with anisotropic plasmonic hybrid nanorods (2015)

Self-organized 3D photonic superstructures loaded with plasmonic hybrid nanorods were found to undergo structural transformation from body-centered cubic to simple cubic upon NIR-light irradiation resulting from the "photothermal effect" of gold nanorods. Furthermore, dynamic NIR light-directed red, green and blue reflections of the nanocomposites were demonstrated.
Charge-Carrier Evolution in Electrically Conducting Substituted Polymers Containing Biheterocycle/p-Phenylene Repeat Units (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCharge-Carrier Evolution in Electrically Conducting Substituted Polymers Containing Biheterocycle/p-Phenylene Repeat UnitsAndrew D. Child, Balasubramanian Sankaran, Fernando Larmat, and John R. ReynoldsCite this: Macromolecules 1995, 28, 19, 6571–6578Publication Date (Print):September 1, 1995Publication History Published online1 May 2002Published inissue 1 September 1995https://pubs.acs.org/doi/10.1021/ma00123a026https://doi.org/10.1021/ma00123a026research-articleACS PublicationsRequest reuse permissionsArticle Views252Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts