gebhart/patrepeval huggingface dataset:
Supplementary Figure 4 from Cancer-Associated Fibroblasts Expressing CXCL14 Rely upon NOS1-Derived Nitric Oxide Signaling for Their Tumor-Supporting Properties (2023)

&lt;p&gt;PDF file - 42KB, Nos1 is induced upon oxidative stress in NIH3T3 fibroblasts.&lt;/p&gt;
Extracellular electrical activity recording of pancreatic islet (2003)

Insulin release is well-known to be correlated with bursting of islets of Langerhans. Spikes generated during these burstings have also been found to have a linear relationship with glucose concentration. This linear relationship could allow one to make a sensitive, continuous "living" glucometer by recording extracellular electrical activity of islet of Langerhans. In this study, we investigate the feasibility of processing a three dimensional biocompatible microelectrode which could support pancreatic islets and record their extracellular activity. We also used mathematical modelling in order to assess the influence of the microelectrode on the membrane potential of the islet. A three-dimensional polyimide-based microelectrode has been designed. First results of numerical simulations show the effect of the probe on the bursting activity of the islets.
d,l- and meso-Isochrysohermidin: total synthesis and interstrand DNA crosslinking (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTd,l- and meso-Isochrysohermidin: total synthesis and interstrand DNA crosslinkingDale L. Boger and Carmen M. BaldinoCite this: J. Am. Chem. Soc. 1993, 115, 24, 11418–11425Publication Date (Print):December 1, 1993Publication History Published online1 May 2002Published inissue 1 December 1993https://pubs.acs.org/doi/10.1021/ja00077a046https://doi.org/10.1021/ja00077a046research-articleACS PublicationsRequest reuse permissionsArticle Views1356Altmetric-Citations67LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
FUNCTIONAL PROPERTIES AND NUTRITIONAL QUALITY OF ALKALI‐ AND HEAT‐TREATED SOY PROTEIN ISOLATE (1999)

ABSTRACT Alkali and heat are increasingly utilized in food processing. This study was conducted to evaluate specific functional and nutritional properties of alkali‐ and heat‐treated soy protein isolate (AHSPI) and the relationship between these properties. High pH (12.0) and temperature (100C) increased protein solubility of the isolate from 47 to 99.5% and emulsifying activity index from 74 to 184 m 2 /g. The values for in vitro protein digestibility (IVPD), computed‐protein efficiency ratio, and IVPD‐corrected amino acid score of AHSPI were not significantly (P&gt;0.05) affected at pH 8.0 or 10.0, but were reduced At pH 12.0. At pH 12.0, lysinoalanine content significantly (p&lt;0.05) increased from 0.39 to 1.22 g/100g protein as temperature was increased from 40 to 100C. Improvements in functional properties of soy proteins can be obtained through combined alkali and heat treatments. However, very high pH and temperature should be avoided to maintain nutritional quality of the proteins.
Demonstrating the use of OAM modes to facilitate the networking functions of carrying channel header information and orthogonal channel coding (2020)

We experimentally demonstrate the use of orbital angular momentum (OAM) modes as a degree of freedom to facilitate the networking functions of carrying header information and orthogonal channel coding. First, for carrying channel header information, we transmit a 10 Gb/s on-off keying (OOK) data channel as a Gaussian beam and add to it a 10 Mb/s OOK header carried by an OAM beam with the mode order <i>ℓ</i>=3. We recover the header and use it to drive a switch and select the output port. Secondly, for orthogonal channel coding, we configure transmitters to generate orthogonal spatial codes (orthogonal spatial beam profiles of OAM modes), each carrying an independent data stream. We measure the correlation between the OAM codes and demonstrate their use in a multiple access system carrying two 10 Gb/s OOK data channels. At the end of this Letter, we combine the concepts of using OAM modes for carrying channel header information and orthogonal channel coding in one experiment. We transmit a 10 Gb/s OOK data channel as a Gaussian beam and add to it two 10 Mb/s OOK header waveforms carried by different OAM codes. In the routing node, we recover one of the headers to drive the switch.
An Ultrasound ASIC With Universal Energy Recycling for >7-m All-Weather Metamorphic Robotic Vision (2022)

An ultrasound ASIC that enables compact, 3-D nonvisual robotic navigation for >7-m is presented. The proposed ultrasound ASIC mitigates the limitations of camera vision navigation systems in all-weather, low-power, low-cost aspects. The ASIC integrates TX and RX paths for 64 channels, enabling four-directional navigation using 4 <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\times $ </tex-math></inline-formula> 4 ultrasound arrays. The proposed universal energy recycling transmitter (UERTX) driver circuit, which can drive both single-ended and differential transducers, reduces energy consumption by 44% compared with non-overlap switching-assisted conventional class-D ultrasonic drivers, addressing large TX power consumption. In addition, the on- chip programmable power management unit (PMU) eliminates off-chip supplies and reduces off-chip passive components for compact system miniaturization. Furthermore, PMU enables the tuning of TX driving amplitude for the range of 6–14 <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\text{V}_{\mathrm {pp}}$ </tex-math></inline-formula> allowing wide detection range adaptability. Fabricated in 0.18 <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\mu \text{m}$ </tex-math></inline-formula> 1P6M standard CMOS, the ASIC system measures 25 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and has >7-m obstacle detection capability while consuming 4.3 mW/channel. The proposed ultrasound ASIC system is demonstrated with a four fps, 3-D navigating metamorphic robot, which consumes 0.28 W, occupies 125 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> , and weighs ≤100 g.
Total Synthesis of (+)-Cystothiazole A (2003)

[structure: see text]. The total synthesis of cystothiazole A is described. Key steps of the synthesis include an Evans asymmetric catalytic aldol reaction, which established the required C4-C5 stereochemistry. The [2,4']-bis(thiazole) was obtained applying our methodology of electrophilic activation of amide. Semistabilized Wittig reaction between the phosphonium salt 3 and the aldehyde 2 afforded 1 in nine linear steps and 38% overall yield.
The Short-Time-Scale Transient Processes in High-Voltage and High-Power Isolated Bidirectional DC–DC Converters (2008)

This paper discusses the short-time-scale transient processes in an isolated bidirectional dc-dc converter with phase-shift control. The deadband effect on the steady-state and transient commutating process are analyzed. The current variations caused by phase-shift errors at the boundary conditions are simulated and validated through experiments. The concept of ldquoenergy deadbandrdquo is introduced to describe those specific transients where no energy flows from source to load or load to source. A set of strategies are proposed to increase the system robustness. Simulation and experiments on a 200-V/400-V, 6-kW DC-DC converter prototype validated these strategies.
Spatial Channel Cross-Connect Architectures for Spatial Channel Networks (2020)

A spatial channel network (SCN) is a novel optical network architecture targeting the space division multiplexing (SDM) era where the optical layer is explicitly evolved into the hierarchical SDM layer and wavelength division multiplexing layer, and an optical node is decoupled into a spatial channel cross-connect (SXC) and a wavelength cross-connect to form a hierarchical optical cross-connect. In this article, we discuss a wide variety of SXC architectures based on optical matrix switches (MSs) and newly proposed core selective switches (CSSs) from the viewpoints of connection flexibility and architectural complexity. After briefly reviewing the architecture and functionalities of an SCN and its building-block optical devices, novel SXC architectures based on sub-MSs and CSSs are described and formulas are derived for each SXC architecture that give the required number of optical devices, switching mirrors, and internal fiber connections. Based on the formulations, these architectures are compared with traditional SXC architectures based on a high-port count full-MS pair and a Clos network from the viewpoints of the freedom of connection functionalities, operational benefits, and potential node costs associated with the architectural complexity in order to obtain insights regarding which network application is suited to each SXC architecture.
A1 adenosine receptor occupancy and availability after 5-day regular coffee consumption and subsequent abstention (2022)

Ziel/Aim The stimulating effects of commonly consumed caffeine, the major psychostimulant ingredient of coffee, are evoked through non-selective antagonism at adenosine receptors. [F-18]CPFPX is a highly selective and affine ligand at the A1 adenosine receptor (A1AR) and has been successfully implemented as PET ligand. Here, we quantified by [F-18]CPFPX PET the in vivo brain occupancy of A1AR after short-term coffee consumption during sleep restriction and subsequent abstinence in the human brain.
Mechanisms of cellular injury in ischemic acute renal failure. (1998)

Significant advances have been made in understanding the pathophysiology of injury at the cellular level in ischemic acute renal failure. Alterations in the actin cytoskeleton are of central importance to the structural, physiological, and biochemical changes that occur in proximal tubule cells during acute ischemic injury. These cytoskeletal alterations occur rapidly and are dependent on the severity and duration of ischemic injury. Most importantly, alterations in the actin cytoskeleton are responsible for changes in the cell surface membrane that modify cell polarity, cell-cell interactions, and cell-matrix interactions. Ultimately, these cytoskeletal alterations play a major role in the decrement in glomerular filtration rate that is the hallmark of ischemic acute renal failure.
<title>Using fMRI to guide neurosurgery in a combined 1.5Tesla MR operating room</title> (2001)

To take advantage of MR-guided surgical procedures performed in a combined MR-OR, we have implemented and validated a practical fMRI scheme for localizing primary motor area and assessing its proximity to a lesion volume. The fMRI scheme consists of a dynamical blood oxygenation level dependent (BOLD) imaging technique and a motor task paradigm. The functional imaging was based on gradient-echo (GE) echo planar imaging (EPI) (TR/TE equals 3000/50 m sec). The task paradigm involves a periodic finger movement in which subject was instructed to tap his/her thumb on the other four fingers sequentially as well as to alternate between the right and left sides. During the task, a dynamical fMRI was performed concurrently covering the volume of interest. By using the fMRI scheme, we have successfully performed ten fMRI examinations immediately prior to surgery in the combined MR- OR on the same surgical table top to localize the eloquent functional area of interests. Also we have developed methods of detrending and presenting fMRI results to neurosurgeons in an intuitive 3-dimensional surface-rendered display format that closely matches the patient head position under intervention. Representative cases showed that fMRI results helped neurosurgeons making the optimal surgical decisions prior to craniotomy.
Video material archive system for efficient video editing based on media identification (2005)

This paper proposes a new media identification related application; a video material archive system for efficient video editing. This system allows content creators to track the usage history of all the archived materials to support their access to the desired materials. It also provides the citation frequency of each material so that creators can measure its importance. A feature-based media identification method is employed to create the usage history and the citation frequency data. Experimental results show that the use of this identification method makes it possible to create those data fully automatically without forcing any changes to the existing devices.
Deployment Study Length (2015)

There are many different ways to evaluate a novel interactive system. However, placing that system into the hands of real users and allowing them to use it as they would like in their natural environments may arguably be the best approach to understand if it "really" works. This is because findings learned from user studies conducted in the lab or a controlled setting are limited in external validity and therefore might not generalize beyond the studied usage scenario. Furthermore, the scenario used in a controlled study often lacks full authenticity, and thus it may not faithfully represent situations from the users' live.
Tenilsetam prevents early diabetic retinopathy without correcting pericyte loss (2006)

Hyperglycemia-induced mitochondrial overproduction of reactive oxygen species leads to the activation of different biochemical pathways involved in endothelial damage of the diabetic retina. Tenilsetam [(+/-)-3-(2-thienyl)-2-piperazinone] is a dicarbonyl scavenger in the millimolar range and a transition metal ion chelator in the micromolar range. We tested its effect on experimental diabetic retinopathy, and on endothelial cell characteristics in vitro. Streptozotocin diabetic male Wistar rats (60 mg/kg BW) received 50 mg/kg BW tenilsetam (D-T) for 36 weeks, or no treatment (D). The impact of tenilsetam (0-30 mM) on endothelial proliferation, apoptosis, sprouting, cytokine-induced leucocyte-endothelial interaction, and VEGF expression was tested in vitro. Tenilsetam did not affect glycemic control or body weight in diabetic animals. The 3.7 fold increase in acellular capillaries in diabetic rats [p < 0.001 vs. non-diabetic controls (N)] was reduced by 70% (p < 0.001) through treatment, but pericyte loss (D vs. N -33%; p < 0.001) remained unaffected. In vitro, tenilsetam inhibited endothelial proliferation at lower doses, while inducing apoptosis at high doses. Leucocyte adhesion was only inhibited at high doses. Sprouting angiogenesis of bovine retinal endothelial cells was promoted at lower doses (< or = 10 mM). At micromolar concentrations, endothelial VEGF expression was upregulated by 100%. Long-term treatment with the AGE-inhibitor and iron-chelating compound tenilsetam inhibits the formation of acellular capillaries without correcting pericyte loss. The compound has dose-dependent effects on endothelial cell function. These data suggest that, independent of known properties, tenilsetam shows important rescue functions on endothelial cells which could be useful for the treatment of early diabetic retinopathy.
Measurement of the branching fraction and $$C\!P$$ asymmetry in $${{{B} ^+}} \!\rightarrow {{J /\psi }} {{\rho } ^+} $$ decays (2019)

The branching fraction and direct CP asymmetry of the decay B + J/ + are measured using protonproton collision data collected with the LHCb detector at centre-of-mass energies of 7 and 8 TeV, corresponding to a total integrated luminosity of 3 fb -1 . The following results are obtained:
O2‐09‐04: Changes in Retinal Signs and their Associations with Cognitive Performance: The Multi‐Ethnic Study of Atherosclerosis (MESA) (2016)

Microvascular disease may be an important cause of cognitive decline and dementia in older adults. Previous studies have shown microvascular changes in the retina (e.g., retinopathy, retinal vessel caliber changes) associated with hypertension, inflammation, diabetes, stroke, and cardiovascular disease are also associated with cognitive dysfunction, brain imaging abnormalities and an increased risk for dementia. We used repeated retinal imaging data from MESA Exams 2 and 5 (8 years apart) to determine the associations between retinal microvascular changes and cognitive test scores at MESA Exam 5 (n=3,997). MESA participants had retinal imaging at two time points, which included measures of retinopathy and changes in retinal vessel caliber equivalents of arterioles (CRAE) and venules (CRVE). Cognitive performance at Exam 5 included assessment of: Cognitive Abilities Screening Instrument (CASI, version 2), Digit Symbol Coding (DSC) and Digit Span (DS) forwards and backwards. Cognitive impairment was conservatively defined by a low CASI score (bottom 10% of race-specific distributions). All linear and logistic regression models were adjusted for age, sex, education, and APOE ε4 genotype; interactions by APOE-ε4 genotype, baseline hypertension and diabetes and were considered. At Exam 5 cognitive testing, the mean age participants was 70±9, 53% were women and 51% were non-Hispanic White. Larger CRVE at Exam 2 (p=0.04) and increases in CRAE over 8 years (p=0.02) were associated with lower CASI scores. Each 10% increase in CRAE over time was associated with a higher odds of having a cognitive impairment [OR(95%CI)=1.17(1.01-1.35)]. The presence of retinopathy and greater CRVE at Exam 2 and Exam 5 was strongly associated (p<0.001) with slower speed of processing, as measured by DSC. The magnitude of associations between retinal measures and CASI scores differed by race and were more evident only among normotensive and APOE-ε4 negative individuals. Retinal microvascular signs are associated with lower cognitive performance and higher likelihood of cognitive impairment, specifically among normotensive and APOE-ε4 negative participants. These findings demonstrate that antecedent retinal microvascular changes are associated with global cognitive performance and speed of processing among a diverse cohort of community dwelling older adults.
Geometric Feedback System for Robotic Spraying (2022)

Abstract In this paper, we tackle the task of replacing labor intensive and repetitive manual inspection of sprayed concrete elements with a sensor-based and automated alternative. We present a geometric feedback system that is integrated within a robotic setup and includes a set of depth cameras used for acquiring data on sprayed concrete structures, during and after fabrication. The acquired data are analyzed in terms of thickness and surface quality, with both sets of information then used within the adaptive fabrication process. The thickness evaluation is based on the comparison of the as-built state to a previous as-built state or to the design model. The surface quality evaluation is based on the local analysis of 3D geometric and intensity features. These features are used by a random forest classifier trained using data manually labelled by a skilled professional. With this approach, we are able to achieve a prediction accuracy of 87 % or better when distinguishing different surface quality types on flat specimens, and 75 % when applied in a full production setting with wet and non-planar surfaces. The presented approach is a contribution towards in-line material thickness and surface quality inspection within digital fabrication.
CPU ray tracing large particle data with balanced P-k-d trees (2015)

We present a novel approach to rendering large particle data sets from molecular dynamics, astrophysics and other sources. We employ a new data structure adapted from the original balanced k-d tree, which allows for representation of data with trivial or no overhead. In the OSPRay visualization framework, we have developed an efficient CPU algorithm for traversing, classifying and ray tracing these data. Our approach is able to render up to billions of particles on a typical workstation, purely on the CPU, without any approximations or level-of-detail techniques, and optionally with attribute-based color mapping, dynamic range query, and advanced lighting models such as ambient occlusion and path tracing.
Human Chorionic Gonadotropin Does Not Correlate with Risk for Maternal Breast Cancer: Results from the Finnish Maternity Cohort (2016)

Human chorionic gonadotropin (hCG) is necessary for the maintenance of early pregnancy and promotes normal breast cell differentiation. Administered hCG reduces risk of carcinogen-induced breast cancer in animal models, and higher circulating hCG concentrations were associated with significantly lower long-term risk of breast cancer in a prior nested case-control study. In this study, we investigated early-pregnancy hCG concentrations and subsequent breast cancer risk. We conducted a nested case-control study with 1,191 cases and 2,257 controls (matched on age and date at blood collection) in the Finnish Maternity Cohort, a cohort with serum samples from 98% of pregnancies registered in Finland since 1983. This study included women with a serum sample collected early (<140 days gestation) in their first pregnancy resulting in a live, term birth. Breast cancer cases were identified via the Finnish Cancer Registry. Age at breast cancer diagnosis ranged from 22 to 58 years (mean: 41 years). hCG was measured using a solid-phase competitive chemiluminescence assay. Odds ratios (OR) were calculated using conditional logistic regression. We observed no association between hCG and breast cancer risk, overall [Quartile 4 vs. 1, OR, 1.14; 95% confidence interval (CI), 0.94-1.39], by estrogen and progesterone receptor status, or by ages at first-term birth or diagnosis. Associations did not differ by time between pregnancy and diagnosis (e.g., <5 years, OR<sub>Q4 vs. Q1</sub>, 1.10; 95% CI, 0.64-1.89; ≥15 years, OR<sub>Q4 vs. Q1</sub>, 1.36; 95% CI, 0.86-2.13; p<sub>heterogeneity</sub> = 0.62). This large prospective study does not support an inverse relationship between early pregnancy serum hCG concentrations and breast cancer risk. Cancer Res; 77(1); 134-41. ©2016 AACR.
Pigments of Living Fossil Crinoids (2014)

Stalked crinoids were, for a long time, known as fossils found in different quarries, and also from ocean depths since the great expeditions of the eighteenth century. The chemical analyses of fossils and also of living organisms led to the discovery of new bioactive pigments, and also confirmed that the core structures of these pigments had been preserved during the fossilization process. The existence of these quinoid pigments also leads to several interesting questions related to their stereochemistry and the photoactivation of their bioactivity.