gebhart/patrepeval huggingface dataset:
Assessing Idioms for a Flexible Feature Binding Time (2015)

In software product lines development, it is sometimes important to provide a flexible binding time for features such that developers can choose between static or dynamic feature activation. For example, software products designed for devices with constrained resources may use a static binding time to avoid the performance overhead introduced by dynamic binding time activation. However, other devices can exploit binding time flexibility to support products with a dynamic binding time for some of their features. To implement this kind of flexibility in a modular way, we can define AspectJ-based idioms. Researchers have proposed Edicts, an idiom based on AspectJ and design patterns. In this article, we argue that this idiom leads to an increase in code duplication, scattering, tangling and size, which can hamper code reuse, maintenance and understanding. To mitigate such issues, this paper proposes three idioms based on aspect-oriented programming to implement flexible feature binding. We apply our three idioms, along with Edicts, to implement a flexible binding time for features in four different applications. By doing so, we were able to assess the resulting implementations by using software metrics that judge code-quality factors. Our evaluation suggests that our idioms reduce the above-mentioned problems when implementing flexible feature binding for the selected features.
NOVEL PATHOPHYSIOLOGICAL ROLES OF ALPHA-SYNUCLEIN (SNCA) IN AGE-RELATED VASCULAR ENDOTHELIAL DYSFUNCTION (2021)

Objective: Although SNCA is one of the well-known pathological molecule of synucleinopathy in neurons, its physiological roles remain to be identified. In the present study, we sought to elucidate the novel functions of SNCA in endothelium. Design and method: Analysis for human samples, in vitro experiments using endothelial cells (ECs), and in vivo investigation using SNCA knockout or SNCA/ApoE double knockout mice were performed. Results: We found SNCA was expressed in and secreted from ECs by functional screening for anti-inflammatory molecules and detectable in circulating blood. Intriguingly, the human population study revealed serum SNCA levels decreased with aging and displayed inverse correlation with blood pressure and insulin sensitivity, which indicated protective properties of circulating SNCA on vascular endothelial function. Furthermore, we also found SNCA knockout mice displayed phenotypes of metabolic syndrome such as hypertension, impaired glucose metabolism, and dyslipidemia. Based on these preliminary data, we sought to elucidate the physiological functions of endogenous and exogenous SNCA for ECs. Exogenous treatment with recombinant SNCA (rSNCA) promoted eNOS activation and nitric oxide production via Gab1/PI3K/Akt pathway in ECs, followed by cGMP production in co-cultured vascular smooth muscle cells. Treatment with rSNCA also suppressed TNF-alpha induced NF-kappaB activation in ECs. As to endogenous SNCA, replicative senescence showed attenuation of SNCA expression in ECs and siRNA-mediated silencing of SNCA induced eNOS inactivation and cell senescence assessed by beta-gal activity along with decreased Sirt1 expression and increased p53 expression. SNCA overexpression displayed NF-kappaB inactivation in ECs. In ex vivo study, aortas from SNCA knockout mice showed impairment of acetylcholine-induced relaxation possibly due to eNOS dysfunction. In in vivo study utilizing atherosclerosis model of SNCA/ApoE double-knockout mice showed exaggerated expression of inflammatory genes which play important roles in atherogenesis. Conclusions: In conclusion, these results indicate exogenous and endogenous SNCA in ECs might physiologically maintain cerebral vascular integrity. Aging or aggregation-related loss-of-function of SNCA in ECs might be partially correlated with age-related hypertension or clinical features of dementia with Lewy body such as fluctuating cognitive function and marked sensitivity of antipsychotic which could be modified by cerebral blood flow and vascular permeability.
ChemInform Abstract: Langmuir‐Blodgett Manipulation of Size‐Selected CdSe Nanocrystallites. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Data-driven statistical modeling of a cube regrasp (2016)

Regrasping is the process of adjusting the position and orientation of an object in one's hand. The study of robotic regrasping has generally been limited to use of theoretical analytical models and cases with little uncertainty. Analytical models and simulations have so far proven unable to capture the complexity of the real world. Empirical statistical models are more promising, but collecting good data is difficult. In this paper, we collect data from 3300 robot regrasps, and use this data to learn two probability functions: 1) The probability that the object is still in the robot's hand after a regrasp action; and 2) The probability distribution of the object pose after the regrasp given that the object is still grasped. Both of these functions are learned using kernel density estimation with a similarity metric over object pose. We show that our data-driven models achieve comparable accuracy to a geometric model and an off-the-shelf simulator in classification and prediction tasks, while also enabling us to predict probability distributions.
Supplementary Tables S1 - S18 from Evolution of Neoantigen Landscape during Immune Checkpoint Blockade in Non–Small Cell Lung Cancer (2023)

&lt;p&gt;Supplementary Table S1. Summary of Patient and Sample Characteristics. Supplementary Table S2. Summary of Next-Generation Sequencing Analyses. Supplementary Table S3. Somatic Sequence Alterations*. Supplementary Table S4. Somatic Copy Number Alterations. Supplementary Table S5. Neoantigen Predictions. Supplementary Table S6. Characteristics of a Subset of Eliminated Candidate Neoantigens in the NSCLC patients*. Supplementary Table S7. Summary of Functionally Validated Eliminated, Gained, and Retained cMANAs. Supplementary Table S8. Eliminated MANA-specific T Cell Clonotypes in CGLU116, CGLU127 and CGLU161. Supplementary Table S9. Retained and Gained MANA-specific T Cell Clonotypes in CGLU116. Supplementary Table S10. Allelic Imbalance Analysis and Cellularity Estimates for CGLU116. Supplementary Table S11. Allelic Imbalance Analysis and Cellularity Estimates for CGLU117. Supplementary Table S12. Allelic Imbalance Analysis and Cellularity Estimates for CGLU127. Supplementary Table S13. Allelic Imbalance Analysis and Cellularity Estimates for CGLU161. Supplementary Table S14. Summary of Eliminated Neoantigens in NSCLC Cases. Supplementary Table S15. TCR-beta Sequencing Analysis. Supplementary Table S16. PD-L1 and CD8 Immunohistochemistry. Supplementary Table S17. Regions of Allelic Imbalance. Supplementary Table S18. Tumor Purity and Ploidy Estimates.&lt;/p&gt;
Influence of Intracardiac Pressure on Spontaneous Ventricular Arrhythmias in Patients With Systolic Heart Failure (2013)

There is significant positive association between average daily median ePAD and risk for VT/VF. Among patients with VT/VF, elevated intracardiac pressures are associated with higher VT/VF risk only when the definition of increased pressure is subject specific.
Synthesis and Modeling of Acridine Dyes as Potential Photosensitizers for Dye‐Sensitized Photovoltaic Applications (2006)

We have synthesized novel aromatic amine‐substituted acridine dyes as potential candidates for the photosensitizers in dye sensitized nanocrystalline semiconductor based solar cells (DSSC) cells. The protonation and quaternization of the acridine nitrogen led to acridine dyes with extended absorption from 400–800 nm. Computational modeling was used to evaluate a variety of structures to achieve insights for correlating these types of molecular structures with predicted absorption spectra. Pertinent dihedral angles as well as bond lengths were evaluated to assess and compare planarity and conjugation for these dyes. Other predictions include plots of the HOMO and LUMO levels to qualitatively examine electron distributions and the potential for electron injection. The results from modeling along with the experimental data consisting of synthesis, characterization and UV‐visible absorption properties of the selected dyes are presented.
Sensing the Local Magnetic Environment through Optically Active Defects in a Layered Magnetic Semiconductor (2022)

Atomic-level defects in van der Waals (vdW) materials are essential building blocks for quantum technologies and quantum sensing applications. The layered magnetic semiconductor CrSBr is an outstanding candidate for exploring optically active defects because of a direct gap, in addition to a rich magnetic phase diagram, including a recently hypothesized defect-induced magnetic order at low temperature. Here, we show optically active defects in CrSBr that are probes of the local magnetic environment. We observe a spectrally narrow (1 meV) defect emission in CrSBr that is correlated with both the bulk magnetic order and an additional low-temperature, defect-induced magnetic order. We elucidate the origin of this magnetic order in the context of local and nonlocal exchange coupling effects. Our work establishes vdW magnets like CrSBr as an exceptional platform to optically study defects that are correlated with the magnetic lattice. We anticipate that controlled defect creation allows for tailor-made complex magnetic textures and phases with direct optical access.
IoT Enabled, Leaf Wetness Sensor on the Flexible Substrates for In-Situ Plant Disease Management (2021)

Early plant disease detection and providing the control measures have become highly desirable to improve crop yield. Leaf wetness duration (LWD) is one of the essential parameters related to the development of fungal disease on the leaf canopy. To measured LWD, the leaf wetness sensor (LWS) is widely used. Commercially available LWS are made on printed circuit board (PCB) technology, which has an operational issue during field deployment such as weight of the sensor, contact resistance between the sensor and the leaves, form factor and most importantly, affordability. To mitigate the issues associated with the commercially available LWS, in this work, we have fabricated the in-house IoT-enabled and affordable electronic leaf wetness sensor on the flexible substrates, which is used for integrated plant disease management. Fabricated LWS comprises the interdigitated electrodes (IDEs) on the polyimide flexible substrate. The lab measurement results indicate that fabricated LWS on the flexible substrates offers a response of about 36000% when LWS is exposed to water w.r.t air. The observed response time of the fabricated LWS is about 10 seconds and hysteresis of about ± 4 %. Further, sensor capacitance changes only by 6% over a temperature range from 20 °C to 65 °C. Furthermore, three fabricated sensors LWS and in-house developed internet of things (IoT) enabled systems are deployed on the Ocimum tenuiflorum (Tulsi) medical plant. Field measurement indicates that measured LWD using the fabricated flexible LWS and commercially available LWS (Phytos 31:LWS-L12), METER Group, Inc. USA) shows the absolute difference of 30 minutes.
Professor Friedrich Kohler (1924 to 2007) (2008)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTProfessor Friedrich Kohler (1924 to 2007)Peter Svejda, Kenneth R. Hall, and Kenneth N. MarshCite this: J. Chem. Eng. Data 2008, 53, 10, 2259Publication Date (Web):September 13, 2008Publication History Received1 September 2008Published online13 September 2008Published inissue 9 October 2008https://pubs.acs.org/doi/10.1021/je800659zhttps://doi.org/10.1021/je800659zeditorialACS PublicationsCopyright © 2008 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views468Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (21 KB) Get e-AlertscloseSUBJECTS:Fluids,Liquids,Mixtures,Thermodynamics Get e-Alerts
LCoS microdisplay throughput measurements (2001)

Abstract— We propose a straightforward method to measure the absolute throughput of an LCoS microdisplay. The method requires two measurements. The first measurement is of the lumens delivered from a testbed, which includes the microdisplay under test, with a folded light path. The second measurement is of the lumens delivered by the unfolded testbed with the microdisplay removed. This second measurement is used to normalize the first to obtain a fractional transmission that a designer can use to make a meaningful prediction of the system brightness of a LCoS‐based projection system.
Efficacy of Intravesical Ropivacaine Injection on Urinary Symptoms Following Ureteral Stenting: A Randomized, Controlled Study (2008)

Our preliminary investigation with intravesical injection of ropivacaine before ureteroscopic surgery demonstrated trends toward decreased pain and voiding symptoms in this small-sample study. Inclusion of a larger sample should definitively address the effectiveness of intravesical ropivacaine and its impact on stent-related symptoms.
Word ending-part and phonological memory: a theoretical approach * (2012)

The aim of the present study is to establish that linguistics and psychology can provide the appropriate theoretical framework in order to explain phenomena such as the presence of ending-parts in the form of suffixes, which, however, do not carry the semantic instruction of a suffix. These elements are defined as class markers in Corbin's framework (1987) adopted here. These class markers appear at the end of loanwords and constructed words, especially when these words are prefixed. The role of a class marker is synchronically and diachronically important: Synchronically, because the class marker introduces loanwords and prefixed words either into a grammatical category or into a referential class, i.e. the class of trees; diachronically, because the class marker smoothes over the inflexional system of Modern Greek, especially for verbs and adjectives.
Homogeneous high-flip-angle 3D localization by parallel transmission at 9.4T (2017)

This work presents in vivo experimental result of high-flip-angle multi-dimensional parallel transmission at a 9.4T human whole-body MRI scanner. A 2D pTx saturation pulse (90°) and a slice selective 3D pTx excitation pulse (60°) were designed by using an algorithm that combines LSQR and optimal control (OC) methods and enables high-flip-angle pTx pulse design with a strict constraint of transmit power. An actual flip angle imaging (AFI) sequence was coded to measure the flip angle map of the pre-saturated slice excitation profile achieved by the sequentially implemented pTx pulses.
Advancements in Glass for Packaging Applications (2016)

Glass provides many opportunities for advanced packaging. The most obvious advantage is given by the material properties. As an insulator, glass has low electrical loss, particularly at high frequencies. The relatively high stiffness and ability to adjust coefficient of thermal expansion gives advantages to manage warp in glass core substrates and bonded stacks for both through glass vias (TGV) and carrier applications. Glass also gives advantages for developing cost effective solutions. Glass forming processes allow the potential to both form in panel format as well as to at thicknesses as low as 100 um, giving opportunities to optimize or eliminate current manufacturing methods. As the industry adopts glass solutions, significant advancements have been made in downstream processes such as glass handling and via/surface metallization. Of particular interest is the ability to leverage tool sets and processes for panel fabrication to enable cost structures desired by the industry. By utilizing the stiffness and adjustable CTE of glass substrates, as well as continuously reducing via size that can be made in a panel format, opportunities to manufacture glass TGV substrates in a panel format increase. We will provide an update on advancements in these areas as well as handling techniques to achieve desired process flows. We will also provide the latest demonstrations of electrical, thermal and mechanical reliability.
Presence and Instant Messaging Peering Use Cases (2008)

The document describes several use cases of peering of non-VoIP
services between two or more Service Providers. These Service
Providers create a peering relationship between themselves thus
enabling their users to collaborate with users on the other Service
Provider network. The target of the document is to drive requirements
for peering between domains that provide the non-VoIP based
collaboration services and presence and Instant Messaging (IM) in
particular. Submitter: Avshalom Houri (avshalom@il.ibm.com)
SCA8 repeat expansions in ataxia: A controversial association (2001)

The observation of large SCA8 alleles in healthy control subjects and nonataxic patients, together with a lack of segregation of the expanded repeat with ataxia in several families, has raised questions about the pathogenic role of the SCA8 expansion. The authors found allele sizes within the proposed pathogenic range in three patients with ataxia of unknown etiology, in two individuals from pedigrees with either SCA2 or Friedreich's ataxia, and in two patients with Alzheimer's disease. Sizing of SCA8 alleles should not be a routine diagnostic test until its etiologic role is clarified and the pathogenic threshold is determined.
A General Stereodivergent Strategy for the Preparation of Carbasugars. Syntheses of 5a‐Carba‐α‐D‐glucose, α‐D‐Galactose, and β‐L‐Gulose Pentaacetates from D‐Mannose. (2002)

Abstract For Abstract see ChemInform Abstract in Full Text.
Directed Assembly of Discrete Gold Nanoparticle Groupings Using Branched DNA Scaffolds (2005)

The concept of self-assembled dendrimers is explored for the creation of discrete nanoparticle assemblies. Hybridization of branched DNA trimers and nanoparticle−DNA conjugates results in the synthesis of nanoparticle trimer and tetramer complexes. Multiple tetramer architectures are investigated, utilizing Au−DNA conjugates with varying secondary structural motifs. Hybridization products are analyzed by gel electrophoresis, and discrete bands are observed corresponding to structures with increasing numbers of hybridization events. Samples extracted from each band are analyzed by transmission electron microscopy, and statistics compiled from micrographs are used to compare assembly characteristics for each architecture. Asymmetric structures are also produced in which both 5- and 10-nm Au particles are assembled on branched scaffolds.
(Invited) Nanoscale Chemistry and Electrochemistry with Porous Silicon Nanoparticles (2018)

Prepared by electrochemical or chemical etch of crystalline silicon, porous silicon is an intrinsically strong reducing agent, enabling electroless deposition of noble metals via galvanic displacement. In addition to acting as an electron source, the oxidation of silicon generates water-soluble silicic acid as a chemical byproduct. This combination of electrochemistry and chemistry can be harnessed to form new, functional structures that with interesting applications in sensors, nanomedicine, and catalysis. A biological analog for these chemical and electrochemical processes can be found in cellular autophagy, where cellular components such as proteins and organelles are turned over to generate new cellular functions. The reducing ability of elemental silicon and the low solubility of silicate byproducts allow for inorganic autophagy in silicon nanostructures. For example, in the presence of silver or palladium ions, metal nanoparticles are formed by electroless deposition within a porous Si nanoparticle, generating composite nanoparticles with dimensions and properties controlled by the porous nanostructure. One approach to control the size of the resulting metallic nanoparticles is to use ammine complexes of the metal salt precursors. When the metal coordination complex is reduced, it releases free ammonia that locally dissolves the SiO 2 reaction byproduct that would otherwise lead to heterogeneous metal deposition. The resulting materials can be used as catalysts, imaging probes or as in vivo antibacterial agents. Alternatively, dissolution of Si generates orthosilicic acid, which precipitates in the presence of calcium or magnesium ion to form a structural silicate shell that can be used to trap molecules or other nanostructures for therapeutic or analytic applications. This presentation will discuss the chemistry, the electrochemistry, and the photochemistry of nanostructured porous silicon, with emphasis on the self-destruction and reconstruction processes that can be harnessed for the above-mentioned applications.
The Spoken Web Search Task at MediaEval 2011 (2012)

In this paper, we describe the “Spoken Web Search” Task, which was held as part of the 2011 MediaEval benchmark campaign. The purpose of this task was to perform audio search with audio input in four languages, with very few resources being available in each language. The data was taken from “spoken web” material collected over mobile phone connections by IBM India. We present results from several independent systems, developed by five teams and using different approaches, compare them, and provide analysis and directions for future research.
Deposition of Organosilicon-Based Anticorrosion Layers on Galvanized Steel by Atmospheric Pressure Dielectric Barrier Discharge Plasma (2007)

This work reports on organosilicon-based coatings deposited by atmospheric plasma processes on aluminium-zinc galvanization layers on steel in order to prevent corrosion. Hexamethyldisiloxane (HMDSO) is introduced as a precursor in an atmospheric pressure dielectric barrier discharge (DBD) plasma. Structure of the coating is evaluated by means of white light interferometry (WLI) and fourier transform infrared spectroscopy (FT-IR) measurements. Anti-corrosion properties are measured by means of electrochemistry testing and salt spray exposure. Admixtures of oxidizing gases in the plasma carrier gas enable faster deposition rate and more corrosion resistant organosilicon coatings.
Copy Number Variant Risk Scores Associated With Cognition, Psychopathology, and Brain Structure in Youths in the Philadelphia Neurodevelopmental Cohort (2022)

In this study, elevated CNV risk scores were associated with lower cognitive ability, higher psychopathology including psychosis-spectrum symptoms, and greater deviations from normative magnetic resonance imaging models of brain development. Together, these results represent a step toward synthesizing rare genetic, common genetic, and environmental factors to understand clinically relevant outcomes in youth.