gebhart/patrepeval huggingface dataset:
Abstract 4446: Targeted proteasome inhibition by Velcade induces apoptosis in human mesothelioma and breast cancer cell lines (2010)

Abstract Thoracic malignancies and human breast cancers (HBC) continue to be aggressive solid tumors that are poor responders to the existing chemotherapeutic approaches. Malignant Pleural Mesothelioma (MPM) is an asbestos-related tumor of the thoracic pleura that lacks effective treatment options. Altered ubiquitin proteasome pathway is frequently encountered in many malignancies including HBC and MPM and thus serves as an important target for therapeutic intervention strategies. Although proteasome inhibitor Velcade (Bortezomib) has been under clinical investigation for a number of cancers, limited preclinical studies with this agent have thus far been conducted in HBC and MPM malignancies. Here, we studied the role of Velcade mediated changes in cellular, morphological, and molecular patterns in five MPM (H2595, H2373, H2452, H2461, and H2714) and two HBC (MDA MB-468, SKBR-3) cell lines. Our data revealed significant reduction in cell growth properties that were dose and time dependent. Velcade treatment resulted in G2M phase arrest, increased expression of cyclin-dependent kinase inhibitor p21 and pro-apoptotic protein Bax. Pretreatment of MPM cells with Velcade showed synergistic effect with cisplatin combination regimens. High-throughput gene expression profiling among Velcade treated and untreated MPM cells resulted in identification of novel transducers of apoptosis such as CARP-1, XAF1, and Troy proteins. Thus, Velcade targets cell cycle and apoptosis signaling to suppress MPM and HBC growth in part by activating novel transducers of apoptosis. This pilot study has paved way for further in-depth analysis of the downstream target molecules associated with presensitization of mesothelioma cells in finding effective therapeutic treatment options for both mesothelioma and recalcitrant breast cancers. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4446.
RG 12561 (Dalvastatin): A Novel Synthetic Inhibitor of HMG-CoA Reductase and Cholesterol-Lowering Agent (1993)

RG 12561 (dalvastatin) is a prodrug which converts to its open hydroxyacid form in the body. The Na salt of RG 12561 (RG 12561-Na) is a potent inhibitor of 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase, the rate-limiting enzyme in the cholesterol biosynthetic pathway. It competitively inhibits rat liver HMG-CoA reductase with an IC50 value of 3.4 nmol/l. In the same assay, the IC50 values for other potent HMG-CoA reductase inhibitors, lovastatin-Na and pravastatin, were 2.3 and 8.9 nmol/l, respectively. In Hep G2 liver cells, RG 12561-Na, lovastatin-Na and pravastatin inhibited cholesterol biosynthesis from radiolabeled octanoate with IC50 values of 4 and 5 nmol/l and 1.1 mumol/l, respectively. In a rat ex vivo assay, orally administered RG 12561, lovastatin and pravastatin inhibited cholesterol biosynthesis in liver slices with ED50 values of 0.9, 0.5 and 12 mg/kg, respectively. In cholestyramine-fed hamsters, RG 12561 (0.1% in food for 18 days) reduced LDL cholesterol, whereas HDL was slightly increased. The reductions in the LDL/HDL ratio for RG 12561, RG 12561-Na, lovastatin and lovastatin-Na were 35, 76, 88 and 88%, respectively. At a higher dose, RG 12561 (0.4% in food) reduced serum cholesterol, LDL and LDL/HDL by 84, 97 and 91%, respectively. In WHHL rabbits, RG 12561 and lovastatin (5 mg/kg, b.i.d., 12 days) reduced serum cholesterol by 17 and 16%, respectively. These results demonstrate that RG 12561 is a potent cholesterol-lowering agent.
Review—Solid Electrolytes in Rechargeable Electrochemical Cells (2015)

Solid electrolytes may be used where the electrode reactants are gaseous as in a rechargeable oxide fuel cell or are liquids as in a cell of a rechargeable Na-S battery; porous polymer/oxide composites may be used as a separator where one electrode is a flow-through liquid containing a soluble redox molecule. Where two solid electrodes interact reversibly across an electrolyte, a solid-electrolyte may be used (i) as a separator in a dual liquid-electrolyte cell, (ii) in an all-solid-state battery, or (iii) in contact with an alkali-metal anode on one side and a liquid electrolyte on the other side. A solid-electrolyte interface with the anode would also block from reaching the anode soluble intermediate species of a solid-sulfur cathode reaction in a liquid catholyte. We discuss strategies for realizing the different strategies and introduce the concept of water-solvated glass/amorphous solid cation electrolytes/dielectrics.
The relationship between lymphocyte transformation and immune responses. II. Correlations between transformation and humoral and cellular immune responses. (1969)

Rabbits were immunized against purified proteins, tissue extracts or sheep erythrocytes, with or without Freund's adjuvant. Skin reactions of the delayed type were found only in animals given antigen with adjuvant, although all rabbits developed serum antibodies and most of them Arthus type reactions. Lymphocytes of all animals, however, showed similar transformation activity when cultured with the immunizing antigen. Thus the blast transformation phenomenon correlates well with both cellular and humoral immune responses and not with the delayed type hypersensitivity only.
Influence of Surface Composition on Electronic Transport through Naked Nanocrystal Networks (2014)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTInfluence of Surface Composition on Electronic Transport through Naked Nanocrystal NetworksEvelyn L. Rosen†, April M. Sawvel†, Delia J. Milliron†‡, and Brett A. Helms*†View Author Information† The Molecular Foundry, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, California 94720, United States‡ Department of Chemical Engineering, The University of Texas at Austin, 200 E. Dean Keeton Street, Austin, Texas 78712, United States*E-mail: [email protected]Cite this: Chem. Mater. 2014, 26, 7, 2214–2217Publication Date (Web):March 14, 2014Publication History Received18 December 2013Revised12 March 2014Published online25 March 2014Published inissue 8 April 2014https://pubs.acs.org/doi/10.1021/cm404149uhttps://doi.org/10.1021/cm404149urapid-communicationACS PublicationsCopyright © 2014 American Chemical SocietyRequest reuse permissionsArticle Views1552Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Charge transport,Ligands,Nanocrystals,Thin films,X-ray photoelectron spectroscopy Get e-Alerts
Structure of Sr3V10O28.22H2O (1993)

The crystal structure of hydrated strontium decavanadate, Sr 3 V 10 O 28 .22H 2 O, has been determined. It contains two types of strontium ions: the first is coordinated to seven water molecules which define a pentagonal bipyramid; the second bonds to five molecules of water and three O atoms of different decavanadate ions, thereby bridging between decavanadate ions to produce layers of formula [Sr 2 V 10 O 38 H 20 ] n on the crystallographic plane (100). The heptacoordinated Sr and the five molecules of water associated with it are located between the different layers
Silencing of Tyms and Plk1 Sensitises Malignant Mesothelioma Cells to Gemcitabine (2011)

(1) Background: Nutrition is a key determinant of sarcopenia in later life. (2) Methods: A systematic review of prospective cohort studies examining association of diet quality with muscle mass (MM), muscle strength (MS) or physical performance (PP) among older adults was conducted. A total of 22,885 results were obtained from a literature search in MEDLINE via PubMed and EMBASE up to November 2020. Inclusion criteria included diet quality assessment via dietary indices or statistical approaches, a sample of adults aged 45 years and over at baseline in a longitudinal study design. (3) Results: Of the 22,885 cohort studies, 14 studies were eligible. Meaningful results were obtained for the Mediterranean diet and Nordic diet regarding the decrease of sarcopenia risk, however results from non-European countries were inconsistent. In addition, due to the insufficient number of studies on Japanese Food Guide Spinning Top (JFG-ST), dietary variety score (DVS), and dietary quality index-international (DQI-I), effectiveness was difficult to prove. Studies using factor analysis to examine dietary patterns suggested that the risk of sarcopenia is increased with a high in saturated fat diet such as westernized pattern etc. (4) Conclusion: In this systematic review it was found that various diet qualities are meaningful to a decreased risk of sarcopenia.
Cancer-testis (CT) antigen expression in medulloblastoma (2008)

Medulloblastoma is the most common childhood malignant tumor of the central nervous system. Treatment of medulloblastoma requires harmful therapy and nevertheless carries a poor prognosis. Due to their presence in various cancers and their limited expression in normal tissues, CT antigens are ideal vaccine targets for tumor immunotherapy. CT antigens, such as MAGE and NY-ESO-1, have been employed in clinical trials in various malignancies but little is known about their presence in medulloblastoma. We analyzed 25 medulloblastomas for the expression of a panel of CT antigens by RT-PCR and immunohistochemistry. Messenger RNA expression in the samples was as follows: GAGE 64%, MAGEA3/6 56%, SYCP1 44%, SLCO6A1 32%, MAGEC1 28%, MAGEC2 28%, MAGEA4 28%, NY-ESO-1 20%, MAGEA1 16%, and TPTE 0%. All cases except one (96%) were positive for mRNA expression of at least one CT gene. However, CT antigen expression was scarce on a protein level. Immunoreaction to monoclonal antibody E978 (NY-ESO-1) was negative in all cases; MA454 (MAGEA1), 57B (MAGEA4), M3H67 (MAGEA3/6), CT10#5 (MAGEC2) and #23 (GAGE) were each positive in 1 case, while the highest incidence of positive immunostaining, albeit heterogeneous, was seen with CT7-33 (MAGEC1) in 3 out of the 25 cases. The absence of correlation between mRNA and protein expression in medulloblastoma has not been observed in other tumors and further studies addressing the biology of CT antigens are necessary to investigate the present discrepant results.
Muscle cell differentiation is associated with increased insulin receptor biosynthesis and messenger RNA levels. (1989)

Muscle is a major tissue for insulin action. To study the effect of muscle differentiation on insulin receptors, we employed cultured mouse muscle BC3H-1 and C2 cells. In both cell lines differentiation from myoblasts to myocytes was associated with a 5-10-fold increase in specific 125I-insulin binding to intact cells. When 125I-insulin binding was carried out on solubilized myocytes and myoblasts, 125I-insulin binding to myoblasts was low. After differentiation the number of insulin receptors increased 5-10-fold. In contrast to insulin binding, insulin growth factor I receptor binding was elevated in myoblasts and was decreased by 50% in myocytes. Specific radioimmunoassay of the insulin receptor indicated that the increase in insulin binding to myocytes was due to an increase in insulin receptor content. Studies employing [35S]methionine indicated that this increase in insulin-binding sites reflected an increase in insulin receptor biosynthesis. To study insulin receptor gene expression, myoblast and myocyte mRNA was isolated and analyzed on Northern and slot blots. Differentiation from myoblasts to myocytes was accompanied by a 5-10-fold increase in insulin receptor mRNA. These studies demonstrate, therefore that differentiation in muscle cells is accompanied by increased insulin receptor biosynthesis and gene expression.
Observation of theBs0→η′η′Decay (2015)

The first observation of the B(s)(0)→η'η' decay is reported. The study is based on a sample of proton-proton collisions corresponding to 3.0 fb(-1) of integrated luminosity collected with the LHCb detector. The significance of the signal is 6.4 standard deviations. The branching fraction is measured to be [3.31±0.64(stat)±0.28(syst)±0.12(norm)]×10(-5), where the third uncertainty comes from the B(±)→η'K(±) branching fraction that is used as a normalization. In addition, the charge asymmetries of B(±)→η'K(±) and B(±)→ϕK(±), which are control channels, are measured to be (-0.2±1.3)% and (+1.7±1.3)%, respectively. All results are consistent with theoretical expectations.
Suppression of Microphthalmia Transcriptional Activity by Its Association with Protein Kinase C-interacting Protein 1 in Mast Cells (1999)

Microphthalmia (mi) is a transcription factor that plays a major role in the regulation of growth and function in mast cells and melanocytes. Association of mi with other proteins is a critical step in the regulation of mi-mediated transcriptional activation. We found protein kinase C-interacting protein 1 (PKCI) specifically associated with mi in yeast two-hybrid screening. Immunoprecipitation of mi from quiescent rat basophilic leukemic cells or mouse melanocytes resulted in the specific co-immunoprecipitation of PKCI. This association was significantly reduced on engagement of the surface FcepsilonRI of mast cells or engagement of the Kit receptor on melanocytes. Hence, cell activation caused disengagement of mi from PKCI. Microphthalmia was previously shown to activate the mouse mast cell protease 6 (mMCP-6) promoter. Cotransfection of mi with PKCI in NIH 3T3 fibroblasts containing an mMCP-6 promoter-luciferase reporter demonstrated an up to 94% inhibition of mi-mediated transcriptional activation. PKCI by itself, although localized in the cytosol and nucleus of the cells, has no known physiological function and did not demonstrate transcriptional activity. Its ability to suppres mi transcriptional activity in the transient transfected fibroblast system suggests that it can function in vivo as a negative regulator of mi-induced transcriptional activation.
First-Principles Investigations of the Temperature Dependence of Electronic Structure and Optical Properties of Rutile TiO2 (2018)

To gain additional insight into high-temperature functional material properties for applications in optical gas sensing, the temperature effects on the band gap and optical properties of rutile TiO2 are investigated using ab initio methods. By analyzing the contributions from electron–phonon interaction and lattice thermal expansion, we show that the electron–phonon interaction is the dominant factor for temperature band-gap renormalization. As the temperature increases, the band gap increases until 300 K and then narrows above 300 K. This behavior results from the acoustic phonons, which widen the band gap, dominate below 300 K, while the optical phonons, which narrow the band gap, dominate above 300 K. Our study suggests that the band gap is narrowed by about 138 meV at 1000 K. We also investigated the temperature effects on the dielectric constants, the refractive index, as well as the extinction coefficient. Both the rate of decrease of the refractive index at 650 and 800 nm as well as the experimentally derived band gap agree with experimentally measured data as the temperature increases. Our results and computational methods are of interest for developing high-temperature functional materials with applications toward gas sensing.
High coping self-efficacy associated with lower odds of pre-frailty/frailty in older adults with chronic disease (2019)

High coping self-efficacy was associated with greater odds of a robust state. Further consideration should be given to coping self-efficacy in frailty research and intervention development.
Integrating 3D images using laboratory‐based micro X‐ray computed tomography and confocal X‐ray fluorescence techniques (2010)

Abstract The application of non‐destructive imaging to characterizing samples has become more important as the costs of samples increase. Imaging a sample via X‐ray techniques is preferable when altering or even touching the sample affects its properties, or when the sample is fielded after characterization. Two laboratory‐based X‐ray techniques used at Los Alamos include micro X‐ray computed tomography (MXCT) and confocal micro X‐ray fluorescence (confocal MXRF). Both methods create a 3D rendering of the sample non‐destructively. MXCT produces a high‐resolution (sub‐µm voxel) rendering of the sample based upon X‐ray absorption; the resulting model is a function of density and does not contain any elemental information. Confocal MXRF produces an elementally specific 3D rendering of the sample, but at a lower (30 × 30 × 65 µm) resolution. By combining data from these two techniques, scientists provided a more comprehensive method of analysis. We will describe a MATLAB routine written to render each of these data sets individually and/or within the same coordinate system. This approach is shown in the analysis of two samples: an integrated circuit surface mounted resistor and a machined piece of polystyrene foam. The samples chosen provide an opportunity to compare and contrast the two X‐ray techniques, identify their weaknesses and show how they are used in a complementary fashion. Copyright © 2010 John Wiley &amp; Sons, Ltd.
Digital Light Processing and MEMS: an overview (2002)

A new projection display technology called Digital Light Processing/sup TM/ (DLP/sup TM/) accepts digital video and transmits to the eye a burst of digital light pulses that the eye interprets as a color analog image. DLP is based on a microelectromechanical systems (MEMS) device known as the Digital Micromirror Device/sup TM/ (DMD/sup TM/). Invented in 1987 at Texas Instruments, the DMD is a fast, reflective digital light switch. It can be combined with image processing, memory, a light source, and optics to form a DLP system capable of projecting large, bright, seamless, high-contrast color images with better color fidelity and consistency than current displays.
Characterization of Ehrlichia ruminantium membrane protein, erga-cds- 01230 and its role in adhesion to the host cell (2019)

Outer membrane proteins participate to pathogens adhesion to host cells and therefore often mediate cell infection. Such is the case for Ehrlichia ruminantium, an obligate intracellular bacterium that is transmitted by ticks and responsible for cowdriosis, a fatal disease of domestic and wild ruminants. Several experimental vaccines were developed, but the great genetic and presumably antigenic diversity of E. ruminantium make difficult to obtain an effective vaccine against all strains present in the field. In order to propose novel strategies to control cowdriosis, the interaction of E. ruminantium with its host cell, particularly the associated adhesion mechanisms must be first deciphered. A membrane protein of E. ruminantium, ERGA_CDS_01230, a probable iron transporter, initially identified by proteomics approaches in our group, was here studied for its role in host cell adhesion. The recombinant protein was expressed with post-translational glycosylation modifications and tagged GFP/Histidine in Leishmania tarentolae. Using cell biology approaches, we show that recProt01230 is able to adhere to bovine host cells and interacts with proteins from the cell lysate and the "membranes/ organelles” sub-fraction. Furthermore, recProt01230 does not adhere to heparan sulfate but other membrane polysaccharides seem to play a role in E. ruminantium's adhesion to the host cell. Indeed, preliminary experiments have shown that degrading dermatan sulfate and chondroitin sulfate at the cell surface is associated with a reduction of the number of bacteria in the host cells. Moreover, CDS ERGA_CDS_01230 is over expressed at early stages of infection when bacteria begin to attach to their host. So, our results show the implication of ERGA_CDS_01230 in the adhesion of E. ruminantium to host cells. ERGA_CDS_01230 also induces a humoral response in the vaccinated animals. In conclusion, ERGA_CDS_01230 could be a new promising target for vaccine or therapeutics development.
Chemical Resistance and Mechanical Properties of Glass Fiber–Reinforced Plastic Pipes for Oil, Gas, and Power-Plant Applications (2015)

Glass fiber–reinforced plastic (GFRP) composite pipes are used in many diverse applications, including oil, gas, and power plants. These pipes are subjected to various harsh service conditions during their service life. The evaluation of mechanical properties and chemical resistance of these pipes is essential to assess their long-term performance in specific applications. The results of a study to evaluate the chemical resistance and mechanical properties of GFRP pipes for application in oil and gas plants are presented in this paper. Pipe specimens were preconditioned by filling them with 7.5% HCl, 8% H2SO4, and a mixture of 2% NaOH and 2% KMnO4 solutions maintained at 63°C. The preconditioned and fresh pipe specimens were exposed to clean and oily water [a mixture of 10% toluene, 10% kerosene, and 80% brine water (30 g/L NaCl)] maintained at 93°C and 1.5×106 Pa (15 bar) pressure for 1,000 h. The fresh, preconditioned, and exposed pipe specimens were tested to evaluate their axial and hoop tensile strength, water absorption, and loss on ignition. The experimental results did not exhibit major change in the properties of evaluated pipes owing to exposure to clean and oily water at high temperature and pressure. There was minimal or no loss in the axial and hoop strength of the preconditioned or exposed pipes. The absorption and loss of ignition did not increase significantly both due to pre-conditioning and evaluated exposure conditions. The results indicate that GFRP pipes are suitable for application in the oil and gas industry.