gebhart/patrepeval huggingface dataset:
Redox chemistry of the 9-anilinoacridine class of antitumor agents (1987)

9-Anilinoacridines bearing a 1'-NHR substituent on the anilino ring undergo facile, chemically reversible, two-electron oxidation to quinone diimines. The chemical and electrochemical oxidation of three groups of 9-anilinoacridines (1'-substituted derivatives, together with 3'-substituted analogues and acridine-substituted analogues of the clinical antileukemic drug amsacrine) have been studied and their redox potentials determined. For aniline-substituted derivatives, redox potentials (E1/2) correlate well with substituent electronic properties, with electron-donating substituents facilitating oxidation. Substituents in the acridine ring have little effect on redox potentials, indicating minimal transmission of electronic effects from the acridine to the aniline rings. Although the broad class of 9-anilinoacridines show biological activity over a very wide range of structural variations, a 1'-NHR substituent is a common feature of the most active derivatives. Nevertheless, no clear quantitative relationships between redox potential and biological activity could be discerned, and the relevance of this redox chemistry to the mode of action of amsacrine and other 9-anilinoacridines remains unclear.
A telehealth inpatient addiction consult service is both feasible and effective in reducing readmission rates (2022)

The COVID-19 pandemic compelled fast adaptation of telehealth to addiction treatment services. This study aims to examine the feasibility and effectiveness of transitioning an in-person hospital addiction consult service (ACS) to telehealth. The Stanford Hospital ACS adapted to the pandemic by transforming an in-person ACS to a telehealth ACS. We compared 30-day readmission rates in patients with and without an addiction medicine consult pre-pandemic (in-person ACS) and during the pandemic (telehealth ACS). The ACS completed 370 and 473 unique patient consults in the year preceding (in-person consults) and during the pandemic (telehealth consults) respectively. Patients seen by telehealth ACS had decreased 30-day readmission rates consistent with those seen before COVID-19. A telehealth ACS is feasible and effective in the in-patient setting. Telehealth ACS holds promise to extend the reach of substance use disorder evaluation and treatment in underserved areas.
Low RC-Constant Perforated-Channel HFET (2014)

The novel HFET design using perforated channel region under the gate reduces drain and source parasitic resistances due to the current spreading effect in the source-gate and gate-drain regions. Demonstrated results for AlGaN/GaN HFET show that the RONCG time constant reduces around two times using simple and robust perforated channel device processing. These results are especially important for new generations of power switching transistors.
Supplementary Figure 2 from Glioblastoma Cell Enrichment Is Critical for Analysis of Phosphorylated Drug Targets and Proteomic–Genomic Correlations (2023)

&lt;p&gt;PDF file - 129K, Schematic of potential protein sources and contribution to overall signal from tissue analysis.&lt;/p&gt;
Tablet versus phone: Depth perception in handheld augmented reality (2012)

Augmented Reality (AR) applications on mobile devices like smartphones and tablet computers have become increasingly popular. In this paper, for the first time in the AR domain, we present: (1) the influence of different handheld displays and (2) the exocentric depth perception. Unlike egocentric depth perception, exocentric depth perception has not been investigated in AR.
In situ laser Raman spectroscopy studies of the transformation of VOHPO4·0.5H2O and (VO)2P2O7 (2001)

A detailed study of three samples of vanadyl hemihydrate, VOHPO4·0.5H2O, and vanadyl pyrophosphate, (VO)2P2O7, prepared using different methods is described and discussed. VOHPO4·0.5H2O, prepared using (a) the VPA method (V2O5 and H3PO4 refluxed in aqueous HCl), (b) the VPO method (V2O5 and H3PO4 refluxed in isobutanol) and (c) the VPD method (VOPO4·2H2O refluxed in isobutanol), is readily converted to (VO)2P2O7 by heating in an inert gas at 750–775°C. The three samples of (VO)2P2O7 have significant differences in the P–O–P stretch region of the Raman spectra and also exhibit marked differences in their reactivity with oxygen, although the powder X-ray diffraction patterns for the three samples are identical. The VPA-derived (VO)2P2O7 is readily oxidised at 400°C, whereas the VPO-derived (VO)2P2O7 is particularly unreactive. The oxidation/reduction transformations are studied using in situ laser Raman spectroscopy and temperature programmed oxidation and it is shown that the oxidation/reduction process can be cycled many times and the morphology of the crystallite remains unchanged.
A 2.5 kHz Linewidth Widely Tunable Laser with Booster SOA Integrated on Silicon (2018)

We present a semiconductor laser on the heterogeneous silicon integrated platform with 40 nm tuning range across the C+L band and a record-low 2.5 kHz Lorentzian linewidth. An SOA integrated on the same chip boosts the output power from the laser by ~10 dB.
Inorganic Optical Materials: Proceedings of a Conference Held 6-7 August 1996 Denver, Colorado (1996)

This volume presents papers from a conference on inorganic optical materials. Subjects include: advances in phosphate laser glasses for high-power applications; inorganic photosensitive materials; acousto-optic materials and acousto-optic cell applications; and inorganic optical dielectric film.
Diffuse spectroscopy for inhomogeneous metal nanoparticle assays (2006)

We describe a compact computational spectroscopy platform optimized for molecular recognition using metal nanoparticle assays. The objective is motivated by the urgent need for low-cost, portable and high-throughput sensors for point-of-care (POC) clinical diagnostics. Nanoparticle based sensing has been successfully demonstrated for diagnosis and monitoring of infectious diseases, drug discovery, proteomics, and biological agent detection. Molecular binding on the nanoparticle surface is transuded into an optical signal by modification of the nanoparticle extinction spectrum (via a shift in Localized Surface Plasmon Resonance) or by modification of the molecular scattering spectrum (via Surface Enhanced Raman Scattering). Translating a nanoparticle -based molecular recognition system into a functional miniature hand-held biosensor requires spectrometer designs optimized to large area nanoparticle assays and integrated spectral filtering to improve the signal specificity. Large population sampling with small population sensitivity is essential to highly sensitive nanoparticle assay analysis. We describe a multimodal multiplex spectroscopy (MMS) platform that samples the spectral response of up to 10<sup>6</sup> populations of 10-100 nanoparticles in parallel. The advantages of MMS approach include: extremely high signal throughput due to its large aperture and high resolution with small form factor. We will demonstrate a nanoparticle biosensor platform based on MMS. Ultimately, a fully integrated functional miniature nanoparticle based biosensor for real time disease diagnosis in whole blood assays can be realized.
Calcitonin COOH-terminal cleavage peptide as a model for identification of novel neuropeptides predicted by recombinant DNA analysis. (1982)

A strategy is presented for identification of putative neurohormones that were predicted by sequence analysis of recombinant cDNa molecules. The nucleotide sequence of a cloned calcitonin cDNA insert predicts that the proteolytic excision of calcitonin from a 136-amino acid precursor should generate two additional peptides derived from regions flanking the calcitonin sequence on the NH2 and carboxyl termini. The predicted 16-amino acid COOH-terminal cleavage peptide (NH2-Asp-Met-Ala-Lys-Asp-Leu-Glu-Thr-Asn-His-His-Pro-Thr-Phe-Gly-Asn-COOH) was chemically synthesized using solid phase procedures. Antibodies against this synthetic hexadecapeptide detect immunologically cross-reactive material in tissue extracts from normal thyroid glands and calcitonin-producing medullary thyroid carcinomas. Each of the four calcitonin mRNA-directed cell-free translation products contain the immunological determinants for both calcitonin and the COOH-terminal cleavage peptide.
Facilitating separation of bone from bonelike materials in micro-computed tomography images (2014)

Facilitating separation of bone from bonelike materials in micro-computed tomography images
Terminal Complement Components Mediate Release of von Willebrand Factor and Adhesion of Platelets in Arteries of Allografts (2005)

Mononuclear cell infiltration of the arterial intima occurs in the absence of C6, but C6 deficiency limits the release of vWF from arterial endothelial cells.
Better Prophylaxis Against Surgical Site Infection with Local as Well as Systemic Antibiotics (2009)

As we hypothesized, the combination of systemic cefazolin and local gentamicin proved to be the most effective regimen. Local injection of gentamicin proved more effective than systemic administration of cefazolin but was not as effective as the combination of both antibiotics. The initially high concentrations of locally applied antibiotic and the utilization of two different classes of antibiotics may have contributed to the observed efficacy.
Integrin activation (2008)

Agonist stimulation of integrin receptors, composed of transmembrane alpha and beta subunits, leads cells to regulate integrin affinity ('activation'), a process that controls cell adhesion and migration, and extracellular matrix assembly. A final step in integrin activation is the binding of talin to integrin beta cytoplasmic domains. We used forward, reverse and synthetic genetics to engineer and order integrin activation pathways of a prototypic integrin, platelet alphaIIbbeta3. PMA activated alphaIIbbeta3 only after expression of both PKCalpha (protein kinase Calpha) and talin at levels approximating those in platelets. Inhibition of Rap1 GTPase reduced alphaIIbbeta3 activation, whereas expression of constitutively active Rap1A(G12V) bypassed the requirement for PKCalpha. Overexpression of a Rap effector, RIAM (Rap1-GTP-interacting adaptor molecule), activated alphaIIbbeta3 and bypassed the requirement for PKCalpha and Rap1. In addition, shRNA (short hairpin RNA)-mediated knockdown of RIAM blocked talin interaction with and activation of integrin alphaIIbbeta3. Rap1 activation caused the formation of an 'activation complex' containing talin and RIAM that redistributed to the plasma membrane and activated alphaIIbbeta3. The central finding was that this Rap1-induced formation of an 'integrin activation complex' leads to the unmasking of the integrin-binding site on talin, resulting in integrin activation.
Pyridinic-N-Doped Graphene Paper from Perforated Graphene Oxide for Efficient Oxygen Reduction (2018)

We report a simple approach to fabricate a pyridinic-N-doped graphene film (N-pGF) without high-temperature heat treatment from perforated graphene oxide (pGO). pGO is produced by a short etching treatment with hydrogen peroxide. GO perforation predominated in a short etching time (∼1 h), inducing larger holes and defects compared to pristine GO. The pGO is advantageous to the formation of a pyridinic N-doped graphene because of strong NH<sub>3</sub> adsorption on vacancies with oxygen functional groups during the nitrogen-doping process, and the pyridinic-N-doped graphene exhibits good electrocatalytic activity for oxygen reduction reaction (ORR). Using rotating-disk electrode measurements, we confirm that N-pGF undergoes a four-electron-transfer process during the ORR in alkaline and acidic media by possessing sufficient diffusion pathways and readily available ORR active sites for efficient mass transport. A comparison between Pt/N-pGF and commercial Pt/C shows that Pt/N-pGF has superior performance, based on its more positive onset potential and higher limiting diffusion current at -0.5 V.
Assessment of NCHRP Report 350 Test Conditions (2002)

The appropriateness of test conditions specified in NCHRP Report 350 was assessed. The assessment focused on the basic Test Level 3 and addressed two areas of interest: the effects of higher speed limit on impact speed and the appropriateness of 25° for the impact angle. The following conclusions and recommendations were drawn on the basis of the results of the analysis: ( a) the current test impact speed of 100 km/h (62.2 mph) should be maintained, ( b) the current impact angle of 25° for Test 11 of length-of-need sections of permanent longitudinal barriers should be maintained, ( c) the test impact angle should be reduced from 25° to 20° for Test 11 of length-of-need sections of temporary longitudinal barriers, and ( d) the test impact angle should be reduced from 25° to 20° for Test 21 of barrier transition sections. However, the selection of impact conditions is more a policy decision than a technical issue to be resolved in the update of NCHRP Report 350 guidelines.
Preparation and Characterization of Dentin Phosphophoryn‐Derived Peptide‐Functionalized Lignin Nanoparticles for Enhanced Cellular Uptake (2019)

The surface modification of nanoparticles (NPs) using different ligands is a common strategy to increase NP-cell interactions. Here, dentin phosphophoryn-derived peptide (DSS) lignin nanoparticles (LNPs) are prepared and characterized, the cellular internalization of the DSS-functionalized LNPs (LNPs-DSS) into three different cancer cell lines is evaluated, and their efficacy with the widely used iRGD peptide is compared. It is shown that controlled extent of carboxylation of lignin improves the stability at physiological conditions of LNPs formed upon solvent exchange. Functionalization with DSS and iRGD peptides maintains the spherical morphology and moderate polydispersity of LNPs. The LNPs exhibit good cytocompatibility when cultured with PC3-MM2, MDA-MB-231, and A549 in the conventional 2D model and in the 3D cell spheroid morphology. Importantly, the 3D cell models reveal augmented internalization of peptide-functionalized LNPs and improve antiproliferative effects when the LNPs are loaded with a cytotoxic compound. Overall, LNPs-DSS show equal or even superior cellular internalization than the LNPs-iRGD, suggesting that DSS can also be used to enhance the cellular uptake of NPs into different types of cells, and release different cargos intracellularly.
Impact on Image Noise of Incorporating Detector Blurring Into Image Reconstruction for a Small Animal PET Scanner (2009)

We study the noise characteristics of an image reconstruction algorithm that incorporates a model of the non-stationary detector blurring (DB) for a mouse-imaging positron emission tomography (PET) scanner. The algorithm uses ordered subsets expectation maximization (OSEM) image reconstruction, which is used to suppress statistical noise. Including the non-stationary detector blurring in the reconstruction process (OSEM(DB)) has been shown to increase contrast in images reconstructed from measured data acquired on the fully-3D MiCES PET scanner developed at the University of Washington. As an extension, this study uses simulation studies with a fully-3D acquisition mode and our proposed FORE+OSEM(DB) reconstruction process to evaluate the volumetric contrast versus noise trade-offs of this approach. Multiple realizations were simulated to estimate the true noise properties of the algorithm. The results show that incorporation of detector blurring (FORE+OSEM(DB)) into the reconstruction process improves the contrast/noise trade-offs compared to FORE+OSEM in a radially dependent manner. Adding post reconstruction 3D Gaussian smoothing to FORE+OSEM and FORE+OSEM(DB) reduces the contrast versus noise advantages of FORE+OSEM(DB).
Treatment of Severe Esophageal Crohnʼs Disease With Thalidomide (2001)

Department of Gastroenterology, University of Chicago Hospitals, Chicago, Illinois, USA Reprint requests and correspondence: Eli D Ehrenpreis, MD, Department of Gastroenterology, University of Chicago Hospitals, 5841 South Maryland Avenue, MC 4076, Chicago, IL 60637. Received 14 November 2000; accepted 04 December 2000
P‐223: Enhanced Power Efficiency of Single‐Layer White Triplet Polymer Light‐Emitting Diodes by Blending with Polymer Oxides (2008)

Abstract In this study, we have demonstrated enhanced performance of blue, red and white phosphorescent polymer light‐emitting diodes PLEDs) by blending poly(ethylene glycol) (PEG) into the active layer of the devices. By introducing PEG into the PLEDs, the turn‐on voltages of these devices became lower than those of the conventional devices. In addition, the luminance efficiency and the external quantum efficiency of the blue and white phosphorescent PLEDs were both improved. Most important of all, because of the lower operating voltage, the higher power efficiency (7.3 lm/W, 1.5 lm/W, 4.6lm/W) of the blue, red and white phosphorescent PLEDs than those of the control devices (2.9 lm/W, 1.1 lm/W, 1.9 lm/W) have been achieved, respectively. Finally, the improvement mechanism will be discussed.
Probing charge transport in heterostructured phase-segregated hybrid perovskite semiconductors with terahertz radiation (2022)

We employ terahertz radiation to investigate the impact of phase segregation on the charge-carrier dynamics and transport properties of mixed halide perovskite films. We reveal negligible impact on charge-carrier mobilities, and preservation of Drude-like transport. We demonstrate enhanced lattice anharmonicity that underlines the ionic migration mechanisms. We show how minimal structural transformations have a dramatic effect on the charge-carrier dynamics as a result of charge funnelling.
Dimensionally anisotropic graphene with high mobility and a high on–off ratio in a three-terminal RRAM device (2020)

A tailor made strategy for graphene toward logic application was proposed and demonstrated in this work based on its intrinsic dimensionally anisotropic properties: a graphene based three terminal resistive random access memory.
Pretargeted Dual-Modality Immuno-SPECT and Near-Infrared Fluorescence Imaging for Image-Guided Surgery of Prostate Cancer (2014)

Radical removal of malignant lesions may be improved using tumor-targeted dual-modality probes that contain both a radiotracer and a fluorescent label to allow for enhanced intraoperative delineation of tumor resection margins. Because pretargeting strategies yield high signal-to-background ratios, we evaluated the feasibility of a pretargeting strategy for intraoperative imaging in prostate cancer using an anti-TROP-2 x anti-HSG bispecific antibody (TF12) in conjunction with the dual-labeled diHSG peptide (RDC018) equipped with both a DOTA chelate for radiolabeling purposes and a fluorophore (IRdye800CW) to allow near-infrared optical imaging. Nude mice implanted s.c. with TROP-2-expressing PC3 human prostate tumor cells or with PC3 metastases in the scapular and suprarenal region were injected i.v. with 1 mg of TF12 and, after 16 hours of tumor accumulation and blood clearance, were subsequently injected with 10 MBq, 0.2 nmol/mouse of either (111)In-RDC018 or (111)In-IMP288 as a control. Two hours after injection, both microSPECT/CT and fluorescence images were acquired, both before and after resection of the tumor nodules. After image acquisition, the biodistribution of (111)In-RDC018 and (111)In-IMP288 was determined and tumors were analyzed immunohistochemically. The biodistribution of the dual-label RDC018 showed specific accumulation in the TROP-2-expressing PC3 tumors (12.4 ± 3.7% ID/g at 2 hours postinjection), comparable with (111)In-IMP288 (9.1 ± 2.8% ID/g at 2 hours postinjection). MicroSPECT/CT and near-infrared fluorescence (NIRF) imaging confirmed this TROP-2-specific uptake of the dual-label (111)In-RDC018 in both the s.c. and metastatic growing tumor model. In addition, PC3 metastases could be visualized preoperatively with SPECT/CT and could subsequently be resected by image-guided surgery using intraoperative NIRF imaging, showing the preclinical feasibility of pretargeted dual-modality imaging approach in prostate cancer.
Macromol. Biosci. 7/2017 (2017)

Front Cover: A mechanically robust and reproducible artificial biofilm is fabricated by wet- and electrospinning of bacteria with a PVA hydrogel in form of fibers and nonwoven gauzes. The bacteria remain viable and metabolically active (green: alive; red: dead). This artificial biofilms can contribute to resolve fundamental issues of design, scale up and monosepsis in biofuel cell technology. This is reported by Patrick Kaiser, Steffen Reich, Daniel Leykam, Monika Willert-Porada, Andreas Greiner and Ruth Freitag, article number 1600442.
SAFETY OF INTRAVITREAL BEVACIZUMAB IN THE DEVELOPING RABBIT RETINA (2011)

The electroretinographic and morphologic data showed no deleterious effects of a single intravitreal dose of bevacizumab, injected during the first 30 days postnatally, on the structural and functional integrity of the sensory retina in the adult rabbit. Even partial blockage of vascular endothelial growth factor with bevacizumab applied during retinal development seems to interfere with the development of the retinal vascular system in the albino rabbit. However, extrapolation from rabbits to humans should be made with caution.
Selective dysfunction of fast-spiking inhibitory interneurons and disruption of perineuronal nets in a tauopathy mouse model (2023)

In Alzheimer's disease (AD), network hyperexcitability is frequently observed and associated with subsequent cognitive impairment. Dysfunction of inhibitory interneurons (INs) is thought to be one of the key biological mechanisms of hyperexcitability. However, it is still unknown how INs are functionally affected in tau pathology, which is a major pathology in AD. To clarify this, we evaluated the neuronal activity of cortical INs in 6-month-old rTg4510 mice, a model of tauopathy. Calcium imaging with mDlx enhancer-driven labeling revealed that neuronal activity in INs was decreased in rTg4510 mice. In the patch clamp recording, the firing properties of fast-spiking INs were altered so as to reduce their activity in rTg4510 mice. In parallel with microglial activation, perineuronal nets around parvalbumin-positive INs were partially disrupted in rTg4510 mice. Taken together, our data indicate that the excitability of cortical fast-spiking INs is decreased, possibly because of the disruption of perineuronal nets.
Laser emission in Tm 3+ - and Er 3+ -doped fluorozirconate glass at 2.25, 1.88, and 2.70 µm (1988)

Thulium cascade laser operation using resonant pumping was first reported1 in Tm3+:YLF using a ruby laser to pump the 3H4 → 3F3 transition. Recently Tm3+:YLF was pumped with alexandrite and laser diodes, and the 2.3-µm transition was observed.2,3 We report the first observation of Tm3+ laser action in fluorozirconate glass. The Er3+ transition near 3 µm was recently lased in Er3+:YLF using a GaAIAs laser diode pump source.4 The first Er3+ 2.70-μm laser in fluorozirconate glass is reported.
Robust place recognition using local appearance based methods (2002)

We present an approach to the automatic recognition of locations or landmarks using single camera images. Our approach is to learn visual features in the appearance domain that can be used to characterize an object or a location. These features are defined statistically and then are recognized using principal components in the frequency domain. We show that this technique can be used to recognize specific objects on varying backgrounds, as well as environmental features.