gebhart/patrepeval huggingface dataset:
Novel synthesis of the tetracyclic ring system present in streptonigrin (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNovel synthesis of the tetracyclic ring system present in streptonigrinMark Cushman and Jacob MathewCite this: J. Org. Chem. 1981, 46, 24, 4921–4923Publication Date (Print):November 1, 1981Publication History Published online1 May 2002Published inissue 1 November 1981https://pubs.acs.org/doi/10.1021/jo00337a019https://doi.org/10.1021/jo00337a019research-articleACS PublicationsRequest reuse permissionsArticle Views114Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Mitosis and Neurodevelopment Proteins NDE1 and NDEL1 Form Dimers, Tetramers, and Polymers with a Folded Back Structure in Solution (2012)

Paralogs NDE1 (nuclear distribution element 1) and NDEL1 (NDE-like 1) are essential for mitosis and neurodevelopment. Both proteins are predicted to have similar structures, based upon high sequence similarity, and they co-complex in mammalian cells. X-ray diffraction studies and homology modeling suggest that their N-terminal regions (residues 8-167) adopt continuous, extended α-helical coiled-coil structures, but no experimentally derived information on the structure of their C-terminal regions or the architecture of the full-length proteins is available. In the case of NDE1, no biophysical data exists. Here we characterize the structural architecture of both full-length proteins utilizing negative stain electron microscopy along with our established paradigm of chemical cross-linking followed by tryptic digestion, mass spectrometry, and database searching, which we enhance using isotope labeling for mixed NDE1-NDEL1. We determined that full-length NDE1 forms needle-like dimers and tetramers in solution, similar to crystal structures of NDEL1, as well as chain-like end-to-end polymers. The C-terminal domain of each protein, required for interaction with key protein partners dynein and DISC1 (disrupted-in-schizophrenia 1), includes a predicted disordered region that allows a bent back structure. This facilitates interaction of the C-terminal region with the N-terminal coiled-coil domain and is in agreement with previous results showing N- and C-terminal regions of NDEL1 and NDE1 cooperating in dynein interaction. It sheds light on recently identified mutations in the NDE1 gene that cause truncation of the encoded protein. Additionally, analysis of mixed NDE1-NDEL1 complexes demonstrates that NDE1 and NDEL1 can interact directly.
2194-PUB: Structured Basal-Bolus Insulin Injection in Hospitalized Patients with Type 2 Diabetes: Tertiary Teaching Hospital Experience (2020)

Objectives: Although the efficacy of basal-bolus insulin regimen (BBI) in type 2 diabetes (T2D) patients has been demonstrated in clinical studies, few studies have revealed changes in glycemic control following the introduction of BBI in hospital practice. This study was aimed to evaluate the effect of structured BBI in clinical practice for hospitalized patients with T2D. Methods: We retrospectively analyzed non-critically ill T2D patients treated with insulin, who were hospitalized for glycemic control at Seoul National University Hospital (SNUH) from 2004 to 2018. The effects of BBI in T2D patients after 2007, when the current BBI protocol was introduced to SNUH, compared to that of the other types of insulin in T2D patients until 2007. Patients were propensity-score-matched in a 1:1 ratio. Results: Among 294 BBI treated patients (age, 60.4 ± 13.8 years; male, 141 [48.0%]; HbA1c, 10.4 ± 1.9%) and 294 other insulin-treated patients (age, 59.9 ± 12.6 years; male, 148 [50.3%]; HbA1c, 10.3 ± 1.9%), mean admission pre-prandial blood glucose level were 181.0 ± 37.7 mg/dl and 200.0 ± 34.0 mg/dl, respectively (P &amp;lt;0.05). Blood glucose target of &amp;lt;140 mg/dl was achieved in 56.1% of patients in the BBI group and in 33.7% of those in the other insulin group on the sixth day of admission. The mean first target achievement day was 3.6 ± 1.3 days in the BBI group and 4.2 ± 1.5 days in other insulin groups, respectively (P &amp;lt;0.05). Events of hypoglycemia (≤70 mg/dL) and severe hypoglycemia (&amp;lt;55 mg/dL) were not different between the groups. Conclusion: In this study of clinical practice in a tertiary hospital, structured BBI showed significantly improved glycemic control compared to other types of insulin regimens for T2D patients. Disclosure S. Moon: None. H. Jang: None. Y. Yang: None. S. Kwak: None. H. Jung: None. K. Park: None. Y. Cho: None.
Richtlijn Acute promyelocytenleukemie (APL) : richtlijnen voor diagnostiek en behandeling (2018)

Acute myeloïde leukemie (AML) is een heterogene ziekte die wordt gekenmerkt door (oligo)klonale maligne hematopoëse met een blokkade in de differentiatie en daardoor een excessieve toename van leukemische blasten. Acute promyelocytenleukemie (APL) is een zeldzame variant van AML die zich goed laat behandelen met ATRA-bevattende therapie. Vanwege complicaties van de ziekte (trombose, bloeding) is vroege herkenning en start van behandeling extreem belangrijk. Het is daarom belangrijk dat diagnostiek en behandeling van APL-patiënten in de dagelijkse praktijk zorgvuldig en gestructureerd plaatsvindt. Hieronder bespreken we de richtlijnen voor diagnostiek en behandeling zoals de HOVONLeukemiewerkgroep denkt dat die voor APL zou moeten plaatsvinden
Area Effects on Rotating Detonation Engine Performance (2014)

Prior work shows that the thermodynamic cycle of the rotating detonation engine can be analyzed as a ZND planar detonation that is transformed into a rotating frame of reference. The resulting cycle model is independent of geometry and consistent with the Euler turbomachinery equation. A two-dimensional inviscid numerical model confirms the essential features of the analytical cycle. A subsequent examination confirms the operation of the Euler equation in a three-dimensional numerical simulation and is consistent with the modified ZND model. The geometry of the RDE is varied over nine different geometries of area and radius values. Specific impulse is shown to be proportional to area ratio. The range of exit swirl angles are shown to be proportional to the ratio of exit to inlet radii. The correlation of performance or swirl with geometry suggests other factors are equally important.
Therapeutic antibody targeting of Notch3 signaling prevents mural cell loss in CADASIL (2017)

Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a neurological syndrome characterized by small vessel disease (SVD), stroke, and vascular cognitive impairment and dementia caused by mutations in <i>NOTCH3</i> No therapies are available for this condition. Loss of mural cells, which encompass pericytes and vascular smooth muscle cells, is a hallmark of CADASIL and other SVDs, including diabetic retinopathy, resulting in vascular instability. Here, we showed that Notch3 signaling is both necessary and sufficient to support mural cell coverage in arteries using genetic rescue in Notch3 knockout mice. Furthermore, we show that systemic administration of an agonist Notch3 antibody prevents mural cell loss and modifies plasma proteins associated with Notch3 activity, including endostatin/collagen 18α1 and Notch3 extracellular domain in mice with the C455R mutation, a CADASIL variant associated with Notch3 loss of function. These findings open opportunities for the treatment of CADASIL and other SVDs by modulating Notch3 signaling.
Erythrocytosis associated with a novel missense mutation in the BPGM gene (2014)

The ERYTHROPOIETIN (EPO) gene is regulated by the transcription factor Hypoxia Inducible Factor-alpha (HIF-alpha). In this pathway, Prolyl Hydroxylase Domain protein 2 (PHD2) hydroxylates two prolyl residues in HIF-alpha, which in turn promotes HIF-alpha degradation by the von Hippel Lindau (VHL) protein. Evidence that HIF-2alpha is the important isoform for EPO regulation in humans comes from the recent observation that mutations in the HIF2A gene are associated with cases of erythrocytosis. We report here a new erythrocytosis-associated mutation, p.Asp539Glu, in the HIF2A gene. Similar to all reported cases, the affected residue is in close vicinity and C-terminal to the primary hydroxylation site in HIF-2alpha, Pro531. This mutation, however, is notable in producing a rather subtle amino acid substitution. Nonetheless, we find that this mutation compromises binding of HIF-2alpha to both PHD2 and VHL, and we propose that this mutation is the cause of erythrocytosis in this individual.
The Effect of Sunscreen on Skin Elastase Activity Induced by Ultraviolet-A Irradiation (2005)

It has been reported that application of sunscreens prevents the photoaging of skin in animal models and in humans. We irradiated the dorsal skin of hairless mice with ultraviolet-A (UVA), and investigated the effects of sunscreens on skin elastase activity and on skin properties. Six-week-old female HR/ICR hairless mice were used in these experiments. After being treated with either a UVA sunscreen (also containing ultraviolet-B (UVB) sunscreen to eliminate any slight UVB in the UVA lamps; Protection Factor of UVA (PFA)=6, Sun Protection Factor (SPF)=20) or a vehicle, the dorsal skins of mice were irradiated with the UVA lamps at 22.3 J/cm(2)/d, 5 times a week. At the end of 15 weeks skin properties were evaluated and elastase activities were measured. In the vehicle control group, UVA irradiation increased the brightness and yellowing of the skin, decreased the water content of the stratum corneum, increased skin thickness, decreased skin elasticity, increased skin elastase activity, and decreased the ability of the skin to recover in a pinch test, as compared to an unirradiated group. All these differences were statistically significant. In the UVA sunscreen group, both the UVA induced skin damage and the increase in skin elastase activity were significantly inhibited, as compared to the vehicle group. However, as compared to the unirradiated group, skin elastase activity was significantly increased and immediate extensibility of skin (Ue) was significantly decreased, thereby indicating that the UVA sunscreen did not prevent photoaging to the same level as the unirradiated group. These results suggest the partial efficacy of the topical photoprotection from UVA by the sunscreen in inhibiting elastase activation, and also suggest the possibility of reducing photoaging.
ToF-SIMS 3D Analysis of Thin Films Deposited in High Aspect Ratio Structures via Atomic Layer Deposition and Chemical Vapor Deposition (2019)

For the analysis of thin films, with high aspect ratio (HAR) structures, time-of-flight secondary ion mass spectrometry (ToF-SIMS) overcomes several challenges in comparison to other frequently used techniques such as electron microscopy. The research presented herein focuses on two different kinds of HAR structures that represent different semiconductor technologies. In the first study, ToF-SIMS is used to illustrate cobalt seed layer corrosion by the copper electrolyte within the large through-silicon-vias (TSVs) before and after copper electroplating. However, due to the sample's surface topography, ToF-SIMS analysis proved to be difficult due to the geometrical shadowing effects. Henceforth, in the second study, we introduce a new test platform to eliminate the difficulties with the HAR structures, and again, use ToF-SIMS for elemental analysis. We use data image slicing of 3D ToF-SIMS analysis combined with lateral HAR test chips (PillarHall™) to study the uniformity of silicon dopant concentration in atomic layer deposited (ALD) HfO<sub>2</sub> thin films.
Membrane electrical mechanism of basilar artery constriction and pial artery dilation by norepinephrine. (1981)

To study the mechanism by which norepinephrine acts on vascular muscle cell membrane, we recorded membrane potential with intracellular microelectrodes in isolated cat basilar and pial arteries. On addition of norepinephrine concentrations less than 1 microM, pial arteries hyperpolarized and relaxed while basilar arteries depolarized and contracted. Relaxation and hyperpolarization of the pial arteries occurred without the need for addition of any other drug, which indicates the relaxation of spontaneous tone. The relaxation and hyperpolarization could be completely blocked by addition of propranolol before exposure to norepinephrine. The depolarization and contraction of both basilar and pial arteries was blocked by the previous exposure to phentolamine. Electrical spikes were not found spontaneously, but could be induced in both arteries by tetraethylammonium and subsequent addition of norepinephrine, blockable by phentolamine. We conclude that membrane property differences between basilar and pial arte...
Mobile gesture interaction using wearable tactile displays (2009)

We present an interaction method for mobile gesture interaction using wearable tactile displays. We are attempting to show that wrist-worn tactile displays provide adequate feedback to enable reversible and error-resistant gesture-based interaction. In support of this effort, we present pilot study results demonstrating users' sensitivity in perceiving vibratory directional patterns on the wrist.
Is Bitcoin the Only Cryptocurrency in the Town? Economics of Cryptocurrency and Friedrich A.Hayek (2014)

This paper overviews the entire landscape of Bitcoin-like cryptocurrencies. Bitcoin has not emerged out of cryptocurrency competition, but rather became a dominant currency as the first broad market based cryptocurrency. But there are more than a hundred of cryptocurrencies in the market, and some are catching up to Bitcoin. This is a healthy sign of currency competition á la Hayek. Through this competition new technological and security innovations may emerge. In this paper, we point out potential problems with Bitcoin and propose some ideas for an alternative cryptocurrency.
Driver for insole heated by graphite nanoribbons (2019)

Electronic device responsible for constraining the average power delivered to an insole composed of graphite nanoribbons. As the most wearables are power constrained, the main criterion guiding the system design comes down to minimization of power consumption, while retaining sufficient energy to heat the device properly.
Improved CFD modeling of a small data center test cell (2010)

An improved CFD model is presented to predict the thermal field in a small data center test cell. CFD analysis reported in an earlier paper tended to exaggerate hot and cold spots in a small data center test cell as a result of the inability of the CFD model to predict the correct level of mixing of the cold air emanating from the perforated floor tiles and the warmer room air. The same can be said about the mixing of the hot air stream exiting the rack and the surrounding room air. The overall RMS error in the earlier study was 4°C between numerical results and test data. Another indication of low mixing in the CFD results is illustrated in the comparison of the temperature profile along a vertical line in front of the rack between CFD results and test data. While the temperature of the cold flow from the under floor plenum entering the data center was measured to be 12.8°C, temperature measurement at the same location via a temperature mapping tool showed that it is 15°C at 6" above the floor and rising quickly to 17°C at a height of 4 ft. The present investigations yield several improvements to the CFD model, including modeling of the perforated tile flow and rack exhaust flow to conserve both mass and momentum, inclusion of the effects of buoyancy, and an improved thermal boundary condition for the floor. With these improvements, the overall RMS error was reduced to 2°C between numerical results and the same test data reported in.
Heat Shock Protein 90 Inhibitor BIIB021 (CNF2024) Depletes NF-κB and Sensitizes Hodgkin's Lymphoma Cells for Natural Killer Cell–Mediated Cytotoxicity (2009)

HSP90 inhibition has direct antitumor activity in Hodgkin's lymphoma in vitro and in vivo. Moreover, HSP90 inhibition may sensitize Hodgkin's lymphoma cells for NK cell-mediated killing via up-regulation of ligands engaging activating NK cell receptors.
A highly active Ni(II)-triadamantylphosphine catalyst for ultrahigh-molecular-weight polyethylene synthesis (2019)

Here we report that the tri-1-adamantylphosphine-nickel complex [Ad<sub>3</sub>PNiBr<sub>3</sub>]<sup>-</sup>[Ad<sub>3</sub>PH]<sup>+</sup> upon activation with an alkylaluminoxane catalyzes the polymerization of ethylene to ultrahigh-molecular-weight, nearly linear polyethylene (M<sub>n</sub> up to 1.68 × 10<sup>6</sup> g mol<sup>-1</sup>) with initial activities reaching 3.7 million turnovers per h<sup>-1</sup> at 10 °C. Copolymerizations of ethylene with α-olefins such as 1-hexene and 1-octadecene, as well as tert-butyldimethyl(dec-9-en-1-yloxy)silane give the corresponding copolymers with no decrease in activity.
Effect of systemic calcium deficiency on the expression of transforming growth factor‐β in chick embryonic calvaria (1992)

The developmental process of intramembranous ossification involves bone formation directly from mesenchymal differentiation without a cartilage intermediate. We have previously observed that systemic calcium deficiency in the developing chick embryo, produced by long-term shell-less culture, results in the appearance of chondrocyte-like cells in the calvarium, a parietal bone which normally develops via intramembranous ossification. This investigation aims to analyze the mechanism underlying this calcium deficiency-related, aberrant appearance of cartilage phenotype in the chick embryonic calvarium. In view of the reported involvement of transforming growth factor beta (TGF-beta) in osteogenesis and chondrogenesis, we have examined and compared here the expression of TGF-beta in the chick embryonic calvaria of normal (in ovo development, NL), shell-less (SL), and calcium-supplemented SL (SL+Ca) embryos. TGF-beta expression was analyzed at the mRNA level by blot and in situ cDNA hybridization, and at the protein level by immunohistochemistry and immunoblotting. The results presented here indicate that: 1) TGF-beta is expressed in the chick embryonic calvarium by both periosteal cells and osteocytes, as revealed by in situ hybridization and immunohistochemistry; 2) TGF-beta expression is significantly increased in SL calvarium compared to NL calvarium, at both protein and mRNA levels; 3) the number of TGF-beta expressing cells increases in the SL calvarium, particularly along the central, subcambial core region of the bone; and 4) exogenous calcium repletion to the SL embryo affects the expression of TGF-beta such that the pattern approaches that in the NL embryo. Taken together, these results indicate that altered TGF-beta expression accompanies the aberrant appearance of cartilage phenotype caused by systemic calcium deficiency. We postulate that normal cellular differentiation along the osteogenic pathway during embryonic intramembranous ossification is crucially dependent on regulated TGF-beta expression.
Introduction (2009)

An invention attributed to René Lorin of France in 1913 (Hallion, 1995), the ramjet is a remarkable air-breathing engine in its conceptual simplicity. Lacking moving parts and achieving air compression only through internal geometry change, it is capable of extending the operation beyond flight speed when the gas-turbine engine becomes inefficient. The ramjet does not, however, operate from takeoff, and its performance is low at subsonic speeds because the air dynamic pressure is not sufficient to raise the cycle pressure to the efficient operational values.
Analgesic treatment of ciguatoxin-induced cold allodynia (2013)

Ciguatera, the most common form of nonbacterial ichthyosarcotoxism, is caused by consumption of fish that have bioaccumulated the polyether sodium channel activator ciguatoxin. The neurological symptoms of ciguatera include distressing, often persistent sensory disturbances such as paraesthesias and the pathognomonic symptom of cold allodynia. We show that intracutaneous administration of ciguatoxin in humans elicits a pronounced axon-reflex flare and replicates cold allodynia. To identify compounds able to inhibit ciguatoxin-induced Nav responses, we developed a novel in vitro ciguatoxin assay using the human neuroblastoma cell line SH-SY5Y. Pharmacological characterisation of this assay demonstrated a major contribution of Nav1.2 and Nav1.3, but not Nav1.7, to ciguatoxin-induced Ca2+ responses. Clinically available Nav inhibitors, as well as the Kv7 agonist flupirtine, inhibited tetrodotoxin-sensitive ciguatoxin-evoked responses. To establish their in vivo efficacy, we used a novel animal model of ciguatoxin-induced cold allodynia. However, differences in the efficacy of these compounds to reverse ciguatoxin-induced cold allodynia did not correlate with their potency to inhibit ciguatoxin-induced responses in SH-SY5Y cells or at heterologously expressed Nav1.3, Nav1.6, Nav1.7, or Nav1.8, indicating cold allodynia might be more complex than simple activation of Nav channels. These findings highlight the need for suitable animal models to guide the empiric choice of analgesics, and suggest that lamotrigine and flupirtine could be potentially useful for the treatment of ciguatera.
Adaptive scene synchronization for virtual and mixed reality environments (2004)

Technological advances in virtual environments facilitate the creation of distributed collaborative environments, in which the distribution of three-dimensional content at remote locations allows efficient and effective communication of ideas. One of the challenges in distributed shared environments is maintaining a consistent view of the shared information, in the presence of inevitable network delays and variable bandwidth. A consistent view in a shared 3D scene may significantly increase the sense of presence among participants and improve their interactivity. This paper introduces an adaptive scene synchronization algorithm and a framework for integration of the algorithm in a distributed real-time virtual environment. In spite of significant network delays, results show that objects can be synchronous in their viewpoint at multiple remotely located sites. Furthermore residual asynchronicity is quantified as a function of network delays and scalability.