gebhart/patrepeval huggingface dataset:
Growth of abrupt InGaAs(P)/In(GaAs)P heterointerfaces by gas source molecular beam epitaxy (1995)

We demonstrate a novel method for the growth of abrupt InGaAs(P)/In(GaAs)P heterojunctions by gas source molecular beam epitaxy. We find that exposure of freshly grown InP to an As flux during growth interruption between layers of different compositions results in the substitution of surface P atoms and As atoms, thereby generating a strained transition layer at each interface. By assuring a group-III stabilized surface during interruption required to grow InGaAs(P)/In(GaAs)P heterointerfaces, As/P substitution can be avoided, thereby resulting in improved interface quality. Heterointerface abruptness was examined by double-crystal x-ray diffraction and low temperature photoluminescence. The results show that the interfaces grown with the modified switching sequence are considerably more abrupt than those obtained using conventional sequences where As/P interdiffusion extends over several monolayers.
Efficient Fiber Nonlinearity Mitigation in 50-GHz-DWDM Transmission of 256-Gb/s PDM-16QAM Signals by Folded Digital-Back-Propagation and Channelized FBG-DCMs (2014)

We demonstrate DSP-efficient mitigation of intrachannel and interchannel nonlinear impairments in dispersion-managed DWDM transmission by using channelized-FBG-DCMs and dispersion-folded digital-back-propagation, showing similar nonlinearity tolerance as dispersion-unmanaged transmission for 256-Gb/s PDM-16QAM signals over 12×100-km SSMF spans.
An α-diazophosphonic acid monoester: synthesis, stability, and unexpected photochemical behaviour (1982)

The α-diazophosphonic acid monoester salt EtNSOC( [[double bond, length half m-dash]] N)P(OMe)ONa was synthesised and shown to undergo rearrangement to EtNSOCHOPOMe on photolysis in methanol (λ > 300 nm).
Stochastic identification of defects under sensor uncertainties (2011)

SUMMARY This paper presents a new methodology for identifying defects under the presence of both sensor and defect uncertainties. This methodology introduces a representation of the beliefs of both the locations of defects and the sensors each by a probability density function and updates them using the extended Kalman filter. Because the beliefs are recursively maintained while the sensor is moving and the associated observation data are updated, the proposed approach considers not only the current observation data but also the prior knowledge, the past observation data and beliefs, which include both sensor and defect uncertainties. The concept of differential entropy has been introduced and is utilized as a performance measure to evaluate the result of defect identification and handle the identification of multiple defects. The verification and evaluation of the proposed methodology performance were conducted via parametric numerical studies. The results have shown the successful identification of defects with reduced uncertainty when the number of measurements increases, even under the presence of large sensor uncertainties. Furthermore, the proposed methodology was applied to the more realistic problem of identifying multiple defects located on a specimen and has demonstrated its applicability to practical defect identification problems. Copyright © 2011 John Wiley &amp; Sons, Ltd.
Supplementary Material 5 from Androgen Glucuronidation: An Unexpected Target for Androgen Deprivation Therapy, with Prognosis and Diagnostic Implications (2023)

&lt;p&gt;PDF file - 8878K, Supplementary material 5: Representative examples of immunoexpression obtained after incubation of prostate tissue microarrays with the anti-UGT2B15, anti-UGT2B17 or anti-vimentin antibodies: Comparison Untreated vs ADTh for 3.0 and 6.0 months.&lt;/p&gt;
New components for fiber-optic thin-layer chromatography including fluorescence (2007)

In thin-layer chromatography, fiber-bundle arrays have been introduced for spectral absorption measurements in the UV-region. Using all-silica fiber bundles, the exciting light will be detected after re-emission on the plate with a fiberoptic spectrometer. In addition, fluorescence light can be detected which will be masked by the re-emitted light. Therefore, it is helpful to separate the absorption and fluorescence on the TLC-plate. A modified three-array assembly has been developed: using one array for detection, the two others are used for excitation with broadband band deuterium-light and with UV-LEDs adjusted to the substances under test. As an example, the quantification of glucosamine in nutritional supplements or spinach leaf extract will be described. Using simply heating of the amino-plate for derivation, the reaction product of Glucosamine can be detected sensitively either by light absorption or by fluorescence, using the new fiber-optic assembly. In addition, the properties of the new 3-row fiber-optic array and the commercially available UV-LEDs will be shown, in the interesting wavelength region for excitation of fluorescence, from 260 nm to 360 nm. The squint angle having an influence on coupling efficiency and spatial resolution will be measured with the inverse farfield method. Some properties of UV-LEDs for analytical applications will be described and discussed, too.
Monoclonal IgG Immunoglobulinemia with Subsequent Myeloma in Psoriatic Arthritis (1984)

A 42-year-old man had suffered from skin psoriasis for 27 years, psoriasis arthritis for 6 years and corneal crystalline deposits for 1 year, when an IgG-kappa monoclonal immunoglobulin was detected in his serum electrophoretic pattern. All the diagnostic studies for multiple myeloma were negative. However, 16 months later he developed this disease.
Large scale synthesis of the Cdc42 inhibitor secramine A and its inhibition of cell spreading (2006)

We describe a large scale synthesis of secramine A. Consistent with its ability to inhibit activation of the small GTPase Cdc42, we find that secramine A inhibits cell spreading, a process previously shown to be Cdc42-dependent.
Detection of the Class 1 Integrons and SGI1 among <i>Salmonella enterica</i> Serovar Typhimurium DT104, U302, DT120, DT193, and Nontypable Human Isolates (2010)

Salmonella enterica serovar Typhimurium strains of particular phage types, such as DT104, U302, DT120, DT193, and nontypable strains, are often characterized by resistance to multiple antibiotics. This antibiotic resistance can be caused by the presence of the integrons, transposons, Salmonella genomic island 1 (SGI1), or conjugative plasmids. In this study we were interested in the relative contribution of integrons and SGI1 to the antibiotic resistance of the four mentioned phage types and nontypable S. Typhimurium human strains. Altogether 193 isolates were characterized for antibiotic susceptibility, presence of class 1 integrons, and the left junction of SGI1. Based on the presence of class 1 integrons and the left junction of SGI1, all strains could be clustered into three groups. The first group consisted of 69 strains positive for both the class 1 integrons and the left junction of SGI1. The strains of this group belonged mainly to DT104, U302, and DT120 phage types with resistance phenotype ACSSuT or ACSSuTNA. The second group comprised 9 strains which were positive only for the presence of class 1 integrons. In this group were some strains of multiple-antibiotic-resistant phage types: DT120, DT193, U302; and nontypable. The third group consisted of 115 strains in which neither the class 1 integrons nor the left junction of SGI1 were detected. Although the isolates were resistant to 2–8 antibiotics, the most frequent resistance type of these strains were ASSuT and SSu. By nucleotide sequencing of class 1 integrons PCR amplicons, the following embedded gene cassettes were determined: aadA1, aadA2, aadA5, aadA7, blaPSE-1, sat1, dfrA1; and dfrA14. Our study shows a high prevalence and diversity of class 1 integrons embedded antimicrobial gene cassettes and their strong association with SGI1.
Mechanisms of large strain, high strain rate plastic flow in the explosively driven collapse of Ni-Al laminate cylinders (2014)

Ni-Al laminates have shown promise as reactive materials due to their high energy release through intermetallic reaction. In addition to the traditional ignition methods, the reaction may be initiated in hot spots that can be created during mechanical loading. The explosively driven thick walled cylinder (TWC) technique was performed on two Ni-Al laminates composed of thin foil layers with different mesostructues: concentric and corrugated. These experiments were conducted to examine how these materials accommodate large plastic strain under high strain rates. Finite element simulations of these specimens with mesostuctures digitized from the experimental samples were conducted to provide insight into the mesoscale mechanisms of plastic flow. The dependence of dynamic behaviour on mesostructure may be used to tailor the hot spot formation and therefore the reactivity of the material system.
5G Media slice definition (2019)

This document is the outcome of a joined working group setup between the two European Technology Platforms, New European Media (NEM) and Networld2020. The objective was to combine expertise from the media sector which brought application requirements and the network domain which brought expertise in 5G. Nine media&amp;amp;content use cases have been identified by the group that cover most of the common media&amp;amp;content situations from production to consumption.\nFrom these 9 use cases the group has identified 12 parameters that should be used to adapt the network to the application requirements, such as: Latency, Reliability, Data rate, Mobility, User density, Positioning, User Equipment speed.\nLooking to the 5G network capabilities and parameters that could be activated, the last section provides a description of 5G Media Slices. There is a “s” because one of the main conclusions of the paper is that the media chain encompasses a number of functionalities and operations such as content creation, service composition, service aggregation, content distribution, devices, user\ninteraction and interfaces, which requires different slices. Additionally, 5G requirements will be different for production which needs mostly uplink capacities and distribution which needs mostly downlink capacities.\nFor each of the 9 use cases, there is a proposal to allocate 1 or 2 slices, detailed in the conclusion of this paper. The objective of this paper is to provide proposals and reference material to standardisation organisations in order to contribute to the design and specification of 5G Media Slices.
Abstract 1635: OKI-1546 is a selective, orally bioavailable inhibitor of CDK12 that causes tumor regression in multiple preclinical cancer models (2023)

Abstract Background: CDK12 regulates the expression of multiple genes in the DNA damage response (DDR) pathway by phosphorylating the C-terminal domain of RNA polymerase II (CTD pSer2), and it is a potential therapeutic target to exacerbate DNA damage and cell death in DDR-addicted, HER2-amplified, MYC-overexpressing, or EWS-FLI1-positive cancers. PARP inhibitor resistance is often driven by dysregulation of DDR signaling, and CDK12 inhibition may induce a state of DDR deficiency and increase the effectiveness of PARP inhibition. Materials and methods: Biochemical activity was assayed by ADP-glo (Promega), cellular proliferation was quantified by CellTiter-Glo (Promega), and CTD pSer2 was quantified by MSD immunoassay (Meso Scale Discovery). Kinase panels and in vivo studies are described in figure legends. Results: OKI-1546 has a biochemical IC50 of 15 nM against CDK12 and is highly selective for CDK12 and CDK13 when compared to other closely related CDKs; it is 649-, 81-, 11-, and 64-fold selective over CDKs 1, 2, 7, and 9, respectively. This selectivity was further confirmed via testing OKI-1546 against an affinity-based kinase panel. OKI-1546 potently inhibited proliferation of multiple cancer cell lines, with IC50 values that correlated with 50% inhibition of CTD pSer2. In CD-1 mice, OKI-1546 showed 77% oral bioavailability (%F) with a half-life of 2.7 hrs, and SD rats had 81 %F. Furthermore, a single 10 mg/kg dose reached plasma concentrations that surpassed the plasma protein binding-adjusted IC50 of CTD pSer2, which was confirmed in tumor-bearing mice showing 60% CTD pSer2 inhibition in tumors 4 hours after a single oral dose. That same dose translated into 119% tumor growth inhibition following 21 days of daily administration in the BRCA1 wild-type MDA-MB-231 tumor model and 121% tumor growth inhibition following 21 days of daily administration in the BRCA1-mutant MDA-MB-436 tumor model in mice. Four different PARP inhibitors synergistically combined with OKI-1546 to inhibit cell growth in multiple in vitro cancer models. Conclusion: OKI-1546 is a novel, covalent inhibitor of CDK12 and CDK13 that is potent, specific, orally available, and shows in vivo target engagement and tumor growth inhibition in preclinical cancer models. OKI-1546 showed activity in vivo as a single agent and cellular data suggest that inhibition of CDK12 has the potential to enhance the effects of other DDR-targeting therapeutic agents. Citation Format: Alexander A. Strait, David A. Mareska, Jyothi Mahadevan, Christie A. Schulte, Yevgeniy Izrayelit, Mark L. Boys, Richard Woessner. OKI-1546 is a selective, orally bioavailable inhibitor of CDK12 that causes tumor regression in multiple preclinical cancer models [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 1635.
Expanding the Variety of Zirconium‐based Inorganic Building Units for Metal–Organic Frameworks (2019)

Two new zirconium-based metal-organic frameworks with the composition [Zr<sub>6</sub> O<sub>4</sub> (OH)<sub>4</sub> (OAc)<sub>6</sub> (BDC)<sub>3</sub> ] (CAU-26) and [Zr<sub>5</sub> O<sub>4</sub> (OH)<sub>4</sub> (OAc)<sub>4</sub> (BDC)<sub>2</sub> ] (CAU-27) are reported, which were synthesized from acetic acid, a rarely utilized but green and sustainable solvent (BDC<sup>2-</sup> : 1,4-benzenedicarboxylate). Structure determination aided by automated electron diffraction tomography revealed that CAU-26 is composed of layers of well-known {Zr<sub>6</sub> O<sub>8</sub> } clusters interconnected by terephthalate ions. In contrast CAU-27 exhibits a three-dimensional structure with a so far unknown type of one-dimensional inorganic building unit (IBU), which can be rationalized as condensed polyhedron-sharing chains of {Zr<sub>6</sub> O<sub>8</sub> } clusters. CAU-26 occurs as an intermediate of the CAU-27 synthesis and can be isolated easily, when reaction temperature and time are decreased. We were also able to synthesize two isoreticular derivatives of CAU-27 with extended linker molecules by implementing 4,4'-biphenyldicarboxylic acid (H<sub>2</sub> BPDC) and 5,5'-dicarboxy-2,2'-bipyridine (H<sub>2</sub> BIPY). All materials show high thermal and chemical stability as well as permanent microporosity. The excellent stability of CAU-27-BIPY was exploited to synthesize a performant iridium-supported heterogeneous MOF-based catalyst for the direct C-H borylation of arenes.
Prediction of circulatory equilibrium in response to changes in stressed blood volume (2005)

Accurate prediction of cardiac output (CO), left atrial pressure (PLA), and right atrial pressure (PRA) is a prerequisite for management of patients with compromised hemodynamics. In our previous study (Uemura et al. Am J Physiol Heart Circ Physiol 286: H2376-H2385, 2004), we demonstrated a circulatory equilibrium framework, which permits the prediction of CO, PLA, and PRA once the venous return surface and integrated CO curve are known. Inasmuch as we also showed that the surface can be estimated from single-point CO, PLA, and PRA measurements, we hypothesized that a similar single-point estimation of the CO curve would enable us to predict hemodynamics. In seven dogs, we measured the PLA-CO and PRA-CO relations and derived a standardized CO curve using the logarithmic function CO = SL[ln(PLA - 2.03) + 0.80] for the left heart and CO = SR[ln(PRA - 2.13) + 1.90] for the right heart, where SL and SR represent the preload sensitivity of CO, i.e., pumping ability, of the left and right heart, respectively. To estimate the integrated CO curve in each animal, we calculated SL and SR from single-point CO, PLA, and PRA measurements. Estimated and measured CO agreed reasonably well. In another eight dogs, we altered stressed blood volume (-8 to +8 ml/kg of reference volume) under normal and heart failure conditions and predicted the hemodynamics by intersecting the surface and the CO curve thus estimated. We could predict CO [y = 0.93x + 6.5, r2 = 0.96, standard error of estimate (SEE) = 7.5 ml.min(-1).kg(-1)], PLA (y = 0.90x + 0.5, r2= 0.93, SEE = 1.4 mmHg), and PRA (y = 0.87x + 0.4, r2= 0.91, SEE = 0.4 mmHg) reasonably well. In conclusion, single-point estimation of the integrated CO curve enables accurate prediction of hemodynamics in response to extensive changes in stressed blood volume.
Cable Tension Optimization for an Epicardial Parallel Wire Robot (2023)

HeartPrinter is a novel under-constrained 3-cable parallel wire robot designed for minimally invasive epicardial interventions. The robot adheres to the beating heart using vacuum suction at its anchor points, with a central injector head that operates within the triangular workspace formed by the anchors, and is actuated by cables for multipoint direct gene therapy injections. Minimizing cable tensions can reduce forces on the heart at the anchor points while supporting rapid delivery of accurate injections and minimizing procedure time, risk of damage to the robot, and strain to the heart. However, cable tensions must be sufficient to hold the injector head's position as the heart moves and to prevent excessive cable slack. We pose a linear optimization problem to minimize the sum of cable tension magnitudes for HeartPrinter while ensuring the injector head is held in static equilibrium and the tensions are constrained within a feasible range. We use Karush-Kuhn-Tucker optimality conditions to derive conditional algebraic expressions for optimal cable tensions as a function of injector head position and workspace geometry, and we identify regions of injector head positions where particular combinations of cable tensions are optimally at minimum allowable tensions. The approach can rapidly solve for the minimum set of cable tensions for any robot workspace geometry and injector head position and determine whether an injection site is attainable.
Diffractive optics-based nonlinear spectroscopy: application to the study of deterministic protein motion (2003)

Summary form only given. Biological systems constantly transduce various forms of chemical energy into functions in which the inherent response of the system operates at the edge of stability. Excursions from the stability region lead to denaturation; whereas small fluctuations about the stability point lead to highly correlated responses that behave in a deterministic fashion with respect to the function of the system. Exactly how is the bond energy directed in such a complex system and how has the system evolved to minimize entropic losses in conversion efficiency? We have used the oxygen binding heme proteins as model systems for studying the coupling of reaction forces to functionally relevant motions; i.e., structural transitions important to the self regulation of oxygen binding and transport. Since the forces involved become spatially distributed over an enormous number of degrees of freedom, the net relative motions can be exceedingly small (<.1 /spl Aring/). A very sensitive method is needed to detect these motions and the time resolution must be sufficient to follow from the very first events of bond breaking to full relaxation. The use of diffractive optics for the implementation of heterodyne detected grating spectroscopy has recently been demonstrated. The diffractive optic also generates tilted phase fronts to provide true femtosecond time resolution in noncollinear geometries. This approach has sufficient time resolution and sensitivity to follow the mass displacement, as connected through changes in the material index of refraction, to address this issue.
Current and Next Generation Vaccines Against Influenza (2018)

Influenza is an infectious disease. In order to overcome various infectious diseases, many vaccines have been developed so far. Influenza vaccines have played an important role in prevention and control of influenza. However, current influenza vaccines are not perfect. Current influenza vaccines are produced by anticipating influenza viruses that may occur in annual epidemics or pandemics because influenza viruses have characteristic of antigen mutations. Furthermore, current subcutaneous or intramuscular inoculation of vaccine cannot sufficiently induce IgA that plays an important role in defending the entry of pathogens from the mucosa. In order to overcome the drawbacks of these current influenza vaccines, next generation vaccines are under investigation. One candidate is universal influenza vaccine using the antigens that are conserved among influenza virus strains. Another one is mucosal vaccine that can induce IgA on the mucosa of the upper respiratory tract. Here current and next generation influenza vaccines are described.
Expansion of T follicular regulatory cells by OX40L-JAG1 co-signaling ameliorates experimental lupus nephritis (2021)

Abstract Antinuclear autoantibodies (Nabs) promote tissue inflammation involving multiple organs including the kidneys in Systemic Lupus Erythmatosus (SLE). T-follicular helper (TFH) cell-dependent B-cell response plays an essential role in lupus nephritis (LN). TFH and B-cells receive mutual help in the germinal centers (GCs) to enable high-affinity autoantibody production. T follicular regulatory cells (TFR) cells, a specialized subset of CD4+Foxp3+Tregs, suppress GC formation and TFH-dependent B-cell response. Previously, we have shown that the expansion of functional Tregs using soluble OX40L and JAG1 proteins suppressed experimental autoimmune diabetes and thyroiditis. However, unlike other autoimmune diseases, the role of Tregs in lupus remains unresolved. Here, we show that NZBWF1/j mice with severe proteinuria and higher anti-dsDNA IgG levels had increased GC-TFH, GC-B cells, and GC-TFH/GC-TFR ratio in their renal lymph nodes compared to mice with no proteinuria. While total Tregs were significantly higher in mice with proteinuria, GC-TFRs were significantly reduced. Intriguingly, OX40L-JAG1 treatment significantly increased Tregs, GC-TFRs, and reduced GC-TFH/GC-TFR ratio. Periodic OX40L-JAG1 treatment resulted in a significant reduction in GC-B-cells, anti-dsDNA IgG level, proteinuria and kidney pathology, and increased survival. Mechanistic studies showed increased PD1 expression in Tconv cells, Tregs, TFH, and TFR cells, and PD-L1 expression in GC-B-cells suggesting a key role for PD1 signaling in the observed protective effect. Our results show that OX40L-JAG1 treatment expanded TFRs which inhibited GC-B cell activation and NAb production, proteinuria and LN.