gebhart/patrepeval huggingface dataset:
Data-derived SEA for Time domain EMI sensing of UXO (2007)

Electromagnetic induction (EMI) is a prominent technique in Unexploded Ord- nance (UXO) detection and discrimination research. Existing idealized forward models for the EMI response can be defeated by both the material and geometrical heterogeneity of realis- tic UXO. We have developed a new, physically complete modeling system referred to as the Standardized Excitations Approach (SEA). The SEA accounts for all the efiects from these het- erogeneities including their interactions within the object, and is applicable in both the near and far flelds. According to the SEA, the excitation fleld is decomposed into fundamental modes, and the response of a given target to each fundamental mode (denoted as a fundamental solution) is obtained beforehand and saved in a library. In this way, the target response to an arbitrary excitation fleld can be calculated via a simple superposition of these fundamental solutions. The model parameters (i.e., the fundamental solutions) of a given object are extracted from a su-ciently detailed set of measurement data. These parameters will be speciflc to each EMI instrument. The parameter extraction process was developed previously for the frequency domain using the GEM-3 EMI instrument. In this paper, we apply this SEA to time domain using the EM-63 instrument as an example. The receiver coil of the EM63 is a 0.5m by 0.5m square loop and can not be approximated by a point receiver. Therefore, in the model, the data is interpreted as the integration of the secondary fleld over the receiver loop. The objects we consider are all Body of Revolution (BOR) type objects. We exploit the fact that the calculated SEA model parameters also exhibit speciflc behavior because the target is a BOR Thus, the algorithm is improved by enforcing symmetric properties and zero total magnetic charge, which makes the algorithm more robust and more e-cient. Preliminary results show that this approach works well for this time domain EMI instrument. After optimization, this model may be fast enough for implementation in inversion processing algorithms.
Optimized Scratch Drive Actuator for Tethered Nanometer Positioning of Chip-Sized Components (2000)

A novel surface micromachined robot, capable of pushing a 2x2x0.5 mm chip several millimeters while being powered by a gold wire tether is presented. The micro robot uses a unique assembly and packaging process and is created from large arrays of scratch drive actuators (SDA) tethered by gold wires bonded prior to release in an HF acid bath. The wire tether allows for robot transfer to other substrates and driving surfaces, where assembly line positioning tasks can be performed. A device model has been derived to define optimum SDA plate design for any fabrication process. The driving signal has also been optimized, consuming much less electrical power than previously published signals.
Correction to “Enthalpic Signature of Methonium Desolvation Revealed in a Synthetic Host–Guest System Based on Cucurbit[7]uril” (2013)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to "Enthalpic Signature of Methonium Desolvation Revealed in a Synthetic Host–Guest System Based on Cucurbit[7]uril"Yi Wang, Jason R. King, Pan Wu, Daniel L. Pelzman, David N. Beratan*, and Eric J. Toone*Cite this: J. Am. Chem. Soc. 2013, 135, 46, 17650Publication Date (Web):November 11, 2013Publication History Published online11 November 2013Published inissue 20 November 2013https://pubs.acs.org/doi/10.1021/ja408346jhttps://doi.org/10.1021/ja408346jcorrectionACS PublicationsCopyright © 2013 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views579Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (175 KB) Get e-Alertsclose Get e-Alerts
Effect of lattice geometry on optical transmission through subwavelength nanohole arrays (2016)

We theoretically investigate refractive index sensors that are based on extraordinary optical transmission trough plasmonic nanoholes arranged in square and hexagonal lattices. The hexagonal system supports narrower spectral response and larger figure-of-merit values. Due its strong sensitivities, the hexagonal lattice also exhibits larger spectral shifts caused by a thin dielectric film which covers the aperture surface, mimicking a biomolecular layer.
Functional properties of pectin from dragon fruit (Hylocereus polyrhizus) peel and its sensory attributes (2016)

This study was aimed to add value to the disposed dragon fruit peel from the juice industry. Pectin was extracted from the fruit peel and functional properties of pectin and its application in jam processing were investigated. Hunter ‘L*’, ‘a*’, and ‘b*’ values of the dragon fruit peel pectin were 39.95, 34.87 and 20.18 respectively, which showed light red in colour compared to the commercial apple and citrus pectin. In terms of textural properties, the dragon fruit peel pectin showed several characteristics which were similar to apple and citrus pectin. Water holding capacity of the pectin was similar to apple pectin which was 5.50 and 5.45 g/g respectively. Its oil holding capacity and swelling capacity also showed no significant difference ( p >0.05) from that of citrus pectin. It was successfully applied in pineapple jam but at a high percentage of up to 2% to make it well set. For sensory attributes, no significant ( p <0.05) differences were observed between the mean scores of the jam produced using dragon fruit peel pectin and apple pectin except for the colour attribute. It is therefore recommended to use this pectin as a thickener in food products such as low viscous food and beverages
Dendritic oligothiophene bearing perylene bis(dicarboximide) groups as an active material for photovoltaic device (2009)

A dendritic oligothiophene containing perylene bis(dicarboximide) units was synthesized and its electronic properties and photovoltaic performance were investigated.
NOS1AP is a novel molecular target and critical factor in TDP-43 pathology (2022)

Many lines of evidence have highlighted the role played by heterogeneous nuclear ribonucleoproteins in amyotrophic lateral sclerosis. In this study, we have aimed to identify transcripts co-regulated by TAR DNA-binding protein 43 kDa and highly conserved heterogeneous nuclear ribonucleoproteins which have been previously shown to regulate TAR DNA-binding protein 43 kDa toxicity (deleted in azoospermia-associated protein 1, heterogeneous nuclear ribonucleoprotein -Q, -D, -K and -U). Using the transcriptome analyses, we have uncovered that <i>Nitric Oxide Synthase 1 Adaptor Protein</i> mRNA is a direct TAR DNA-binding protein 43 kDa target, and in flies, its modulation alone can rescue TAR DNA-binding protein 43 kDa pathology. In primary mouse cortical neurons, we show that TAR DNA-binding protein 43 kDa mediated downregulation of <i>Nitric Oxide Synthase 1 Adaptor Protein</i> expression strongly affects the NMDA-receptor signalling pathway. In human patients, the downregulation of <i>Nitric Oxide Synthase 1 Adaptor Protein</i> mRNA strongly correlates with TAR DNA-binding protein 43 kDa proteinopathy as measured by cryptic <i>Stathmin-2</i> and Unc-13 homolog A cryptic exon inclusion. Overall, our results demonstrate that <i>Nitric Oxide Synthase 1 Adaptor Protein</i> may represent a novel disease-relevant gene, potentially suitable for the development of new therapeutic strategies.
Phase I trial of lorlatinib in patients with ALK-driven refractory or relapsed neuroblastoma: A New Approaches to Neuroblastoma Consortium study. (2020)

10504 Background: Lorlatinib, a potent ALK inhibitor, exerts unprecedented activity against neuroblastoma (NB) derived xenografts harboring common crizotinib-resistant ALK mutations, leading to a first in child phase I study. Methods: R/R NB patients (pts) &gt; 12 months, with ALK mutations/amplification and prior ALK inhibitor (ALKi) treatment were eligible. Lorlatinib was administered in 28-day courses (C). For pts &lt; 18 years, 5 dose levels (DL) (45, 60, 75, 95, 115 mg/m 2 /day) were assessed. DL5 (115 mg/m 2 /day) expansion is enrolling (cohort A1). For patients &gt; 18 years, two DL (DL3a the adult RP2D of 100 mg/day and DL4a at 150mg/day) were assessed (cohort A2). Primary endpoint was dose-limiting toxicity (DLT) during C1 and neurocognitive toxicity through C2. Blood samples for circulating tumor DNA (ctDNA) were matched to radiologic restaging. Results: From 9/2017 to 1/2019, 33 eligible patients enrolled (13 with prior ALKi therapy), with median age (range) 5.5 years (2-17) on A1, 21.5 years (15-50) on A2. In A1, 3 pts each enrolled onto DL1-3, with no DLT’s. 5/10 pts enrolled on DL4, with no DLT’s. 1/3 on DL5 had a DLT of grade 3 diarrhea, with expansion ongoing. In cohort A2, 5 patients enrolled at 100 mg/day with no DLT’s; 6 enrolled at 150 mg/day, with one DLT (grade 4 reversible psychosis). Most common treatment-related adverse events were weight gain (90%, grade 1-3), hyperlipidemia (90%, grade 1-3), concentration/memory impairment (23%, grade 1-2), peripheral neuropathy (13%; grade 1-2, A2 only), and peripheral edema (10%; grade 1, A2 only). Lorlatinib steady state exposure at DL3 and DL4 was in the range of exposures seen in adult lung cancer patients at the 100 mg and 200 mg DLs. In A1, 1/18 had partial response (PR), 3/18 had minor responses (MR), and 4/18 had stable disease (SD). Of pts with MR, 2/3 had PR of soft tissue and 1/3 had complete response (CR) by MIBG. In A2 pts, 1/10 had CR, 3/10 PR, and 3/10 MR; Notably, 2/3 with PR had CR by MIBG. Of the pts with MR, one had PR and one CR by MIBG. Responses occurred across dose levels, ALK mutations, and in ALKi pre-treated pts with median courses of 2 (1-24) on A1 and 10.5 (2-28) on A2. Serial ctDNA results showed mutant ALK variant allele frequency trajectories that correlated with clinical response and emergence of novel ALK mutations in cis that corresponded with disease progression. Conclusions: Inhibition of ALK-driven NB with lorlatinib occurs with manageable toxicity and objective anti-tumor activity. Prospective ctDNA allows for monitoring of disease and evolution of resistance. Clinical trial information: NCT03107988.
Adaptive Re-Quantization For High Dynamic Range Video Compression (2014)

International audience
Development of LHP with Low Control Power (2007)

&lt;div class="htmlview paragraph"&gt;Using Loop Heat Pipes (LHPs) for controlling the temperature of the source of heat has been considered for many applications. However, traditional LHPs can require significant amounts of power for source temperature control.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;A number of techniques have been identified and implemented to reduce control power requirements. One of the very first design approaches was to thermally couple the liquid line bringing subcooled liquid from the condenser to the vapor line entering the condenser with a number of “coupling blocks”. In another application, a variable conductance heat pipe (VCHP) was used to couple the liquid line to the LHP evaporator.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;A third generation approach has been developed that offers even further reductions in control power. The paper discusses earlier generations of control power reduction approaches with their advantages and disadvantages. It also describes the third generation of the approach, which is currently in manufacturing.&lt;/div&gt;
Abstract LB-236: M4-3-ML2, a novel glycoengineered humanized IgG1 antibody, targeting a membrane-proximal epitope of MCSP/CSPG4 exhibits potent ADCC induction in vitro and in vivo anti-tumoral efficacy in disseminated melanoma models (2012)

Abstract MCSP/CSPG4 is a large transmembrane proteoglycan identified in melanomas as HMW-MAA. In the mouse it is known as neurite growth factor 2 (NG2), a marker of pericyte recruitment. MCSP has been used as a target for clinical imaging of (uveal) melanomas by immunoscintigraphy. MCSP shows uniform and abundant expression in ca. 60-80% of melanoma, and was described in lobular breast carcinoma, glioblastoma, osteo- &amp; chondrosarcoma, and basal cell carcinoma. It is present at high levels on pericytes of tumor neovasculature, but down-regulated as vessels mature. Normal tissue expression is low and it is not detected on PBMCs. We have generated human/Cynomolgus cross-reactive antibodies against a membrane-proximal MCSP epitope by mouse immunization with a linear peptide derived from the membrane proximal D3 domain followed by boosting with melanoma cells. The mouse antibody LC007 was selected for humanization due to its potent induction of ADCC as a chimeric antibody, compared to antibodies to membrane distal epitopes of MCSP. LC007 as chimeric IgG1 and its humanized IgG1 derivative M4-3-ML2 are characterized by the following properties: i) Specific binding to the native epitope on MCSP+ melanoma cells, but no induction of internalization; ii) Specific IHC staining of MCSP+ cells in FFPET samples; iii) ca 10 nM monovalent affinity for hMCSP D3 domain. Moreover, glycoengineering of LC007 and M4-3-ML2 antibodies using GlycoMab technology resulted in increased binding affinity for hFcgRIIIa and enhanced ADCC potency and absolute killing of melanoma cell lines. As expected, neither up to 10 ug/mL wildtype, nor glycoengineered M4-3-ML2 induced relevant cytokine (IL-6, TNF-α, IFN-γ) release in human whole blood supporting that MCSP is not expressed there. Subsequently, we studied anti-tumoral efficacy of the chimeric antibody LC007 and the humanized antibody M4-3-ML2 in disseminated models of MV3 and MDA-MB435 melanoma after i.v. injection of tumor cells in hCD16 transgenic Scid mice, which express the functional human high affinity FcgRIIIa receptor on NK cells. Both, glycoengineered LC007 and M4-3-ML2 mediated efficacy in terms of enhanced median and overall survival in both disseminated xenograft models, and were superior to the respective non-glycoengineered antibodies. Taken together, our studies support MCSP/CSPG4 as an attractive target for antibody-based cancer immunotherapy. Further studies investigating the anti-angiogenic effect of MCSP antibodies via their action on pericytes/vascular smooth muscle cells are ongoing. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr LB-236. doi:1538-7445.AM2012-LB-236
Non-LPS components ofChlamydia pneumoniae stimulate cytokine production through Toll-like receptor 2-dependent pathways (2002)

Recent studies suggest that infection with Chlamydia pneumoniae is associated with atherosclerosis, and that cytokines play an important role in the initiation and progression of Chlamydia-induced inflammation. When freshly isolated peripheral blood mononuclear cells (PBMC) were stimulated for 24 h with sonicated C. pneumoniae, significant amounts of the pro-inflammatory cytokines TNF-alpha and IL-1beta and of the anti-inflammatory cytokine IL-10 were released into the supernatant. The addition of serum increased cytokine release induced by C. pneumonia two- to fivefold (p < 0.01). This effect was not due to complement, mannose-binding lectin (MBL) or lipopolysaccharide-binding protein (LBP). Incubation of PBMC with either anti-Toll-like receptor 4 (TLR4) or anti-CD14 blocking antibodies did not influence the production of cytokines induced by Chlamydia. The induction of cytokines by C. pneumoniae in macrophages from C3H / HeJ mice, known to have a defective TLR4, was identical to that measured in control macrophages from C3H / HeN mice. In contrast, incubation of PBMC with an anti-TLR2 blocking antibody significantly inhibited the production of TNF by 67 % and of IL-1beta by 72 %. In conclusion, C. pneumoniae stimulates cytokine production in a serum-dependent manner, but independently of complement, MBL and LBP. C. pneumoniae induces the pro-inflammatory cytokines TNF and IL-1beta through TLR2, but not TLR4 and CD14.
Objectified body consciousness in relation to recovery from an eating disorder (2020)

In Western society, the feminine body has been positioned as an object to be looked at and sexually gazed upon; thus, females often learn to view themselves as objects to be observed (i.e., objectified body consciousness (OBC)). This study examined the relation between OBC and eating disorder recovery by comparing its components across non-eating disorder controls, fully recovered, partially recovered, and active eating disorder cases. Results revealed that non-eating disorder controls and fully recovered individuals had similarly low levels of two components of OBC, body surveillance and body shame. Partially recovered individuals looked more similar to those with an active eating disorder on these constructs. The third component of OBC, control beliefs, and a conceptually similar construct, weight/shape self-efficacy, did not differ across groups. Results provide support for the importance of measuring aspects of self-objectification, particularly body surveillance and body shame, across the course of an eating disorder.
A Comparison of IRT Theta Estimates and Delta Scores From the Perspective of Additive Conjoint Measurement (2021)

A recently developed framework of measurement, referred to as Delta-scoring (or D-scoring) method (DSM; e.g., Dimitrov 2016, 2018, 2020) is gaining attention in the field of educational measurement and widely used in large-scale assessments at the National Center for Assessment in Saudi Arabia. The D-scores obtained under the DSM range from 0 to 1 to indicate how much (what proportion) of the ability measured by a test of binary items is demonstrated by the examinee. This study examines whether the D-scale is an interval scale and how D-scores compare to IRT ability scores (thetas) in terms of intervalness via testing the axioms of additive conjoint measurement (ACM). The approach to testing is the ConjointChecks (Domingue, 2014), which implements a Bayesian method to evaluating whether the axioms are violated in a given empirical item response data set. The results indicate that the D-scores, computed under the DSM, produce fewer violations of the ordering axioms of ACM than do the IRT “theta” scores. The conclusion is that the DSM produces a dependable D-scale in terms of the essential property of intervalness.
Modeling of HBV and HCV hepatitis with Hepatocyte-like cells (2016)

Chronic liver diseases caused by either hepatitis B or C viruses are a major health problem around the world. Despite major advances accomplished in recent years in understanding the physiology of both viruses using in vitro and/or in vivomodels, there is no vaccine for HCV available. Moreover, susceptibility to acute and chronic infection and the response to treatments are different between HBV or HCV infected patients. Crucial information can be collected using a robust cell model that permits the culture of clinical isolates along with the investigation of the virus-host interaction. The recent progress in the field of cell reprogramming and differentiation has opened new opportunities in viral hepatitis research raising the hopes of developing new improved therapeutics. In this review, we discuss current models for hepatitis B and C studies and their limitations, and also the iPSC model, and its relevance to the viral host cell interactions.
Product‐oriented flavor research: Learnings from the past, visions for the future (2006)

In the past flavor research and the development of new flavorings were constantly driven by the interaction of flavor analysis, structure elucidation, and chemical synthesis accompanied by sensory. Highly potent flavor compounds were identified in numerous food products and helped to establish a powerful toolbox for flavorists. Nowadays we experience the merging of various scientific disciplines, for example medicine, biology, chemistry, and various technologies in the field of flavor research, which shows direct impact on our understanding of flavors. At the same time modern life has profoundly changed our eating habits. This situation generates new challenges for product development teams, which represent all facets of technologies. This paper will illustrate different examples for the evolution of product-oriented flavor research and future trends.
Regulation of P2X2 Receptors by the Neuronal Calcium Sensor VILIP1 (2008)

Extracellular adenosine triphosphate (ATP) activates P2X receptors, which are involved in diverse physiological functions. Using a proteomic approach, we identified the neuronal calcium sensor VILIP1 as interacting with P2X2 receptors. We found that VILIP1 forms a signaling complex in vitro and in vivo with P2X2 receptors and regulates P2X2 receptor sensitivity to ATP, peak response, surface expression, and diffusion. VILIP1 constitutively binds to P2X2 receptors and displays enhanced interactions in an activation- and calcium-dependent manner owing to exposure of its binding segment in P2X2 receptors. VILIP1-P2X2 interactions are also enhanced in hippocampal neurons during conditions of action potential firing known to trigger P2X2 receptor activation. Our data thus reveal a previously unrecognized function for the neuronal calcium sensor protein VILIP1 and a mechanism for regulation of ATP-dependent P2X receptor signaling by neuronal calcium sensors.