gebhart/patrepeval huggingface dataset:
Decacationic [70]Fullerene Approach for Efficient Photokilling of Infectious Bacteria and Cancer Cells (2013)

Photodynamic inactivation of pathogenic bacteria and cancer cells by novel water-soluble decacationic fullerene monoadducts, C<sub>60</sub>[>M(C<sub>3</sub>N<sub>6</sub><sup>+</sup>C<sub>3</sub>)<sub>2</sub>] and C<sub>70</sub>[>M(C<sub>3</sub>N<sub>6</sub><sup>+</sup>C<sub>3</sub>)<sub>2</sub>], were investigated. In the presence of a high number of electron-donating iodide anions as parts of quaternary ammonium salts in the arm region, we found that C<sub>70</sub>[>M(C<sub>3</sub>N<sub>6</sub><sup>+</sup>C<sub>3</sub>)<sub>2</sub>] produced more highly reactive HO<sup>•</sup> radical than C<sub>60</sub>[>M(C<sub>3</sub>N<sub>6</sub><sup>+</sup>C<sub>3</sub>)<sub>2</sub>], in addition to singlet oxygen (<sup>1</sup>O<sub>2</sub>). This finding offers an explanation of the preferential killing of Gram-positive and Gram-negative bacteria by C<sub>60</sub>[>M(C<sub>3</sub>N<sub>6</sub><sup>+</sup>C<sub>3</sub>)<sub>2</sub>] and C<sub>70</sub>[>M(C3N<sub>6</sub><sup>+</sup>C<sub>3</sub>)<sub>2</sub>], respectively. The hypothesis is that <sup>1</sup>O<sub>2</sub> can diffuse more easily into porous cell walls of Gram-positive bacteria to reach sensitive sites, while the less permeable Gram-negative bacterial cell wall needs the more reactive HO<sup>•</sup> to cause real damage.
Numerical Modeling of a Time Reversal Experiment in Shallow Singapore Waters (2006)

The Time Reversal Mirror (TRM) technique is a very useful tool in many underwater applications. Its usefulness in reverberation rejection and underwater communications has already been established through experiments by the Marine Physical Laboratory. The design of a TRM experiment is specific to the location and environment where it is being conducted. This paper presents theoretical and numerical analysis of a time reversal experiment which will be conducted in very shallow water (15-20 m depth) in Singapore waters. The objective of the numerical simulation was to arrive at the various design parameters for the experiment and thus to predict its performance. The main parameters under question were the optimum frequencies to be used and the focusing ranges to be investigated. Extensive measurements were carried out at the selected site to obtain information about the ambient noise, time evolving sound speed structure and also the sound velocity in the sea-bed. The bottom sound speed was computed from the bulk density and porosity of the core samples collected from various locations at the site using an empirical formula. Direct measurements were also done to find out the propagation losses at three different frequencies (7.5, 10 and 12.5 kHz) and at three different depths (4, 8 and 12 m) over a 500 m range. A short description of the system hardware also is presented.
Nth-order multifrequency coherence functions: A functional path integral approach (1979)

A functional (or path) integral applicable to a broad class of randomly perturbed media is constructed for the nth-order multifrequency coherence function (a quantity intimately linked to nth-order pulse statistics). This path integral is subsequently carried out explicitly in the case of a nondispersive, deterministically homogeneous medium, with a simplified (quadratic) Kolmogorov spectrum, and a series of new results are derived. Special cases dealing with the two-frequency mutual coherence function for plane and beam pulsed waves are considered, and comparisons are made with previously reported findings.
Stable Wireless Network Control Under Service Constraints (2017)

We consider the design of wireless queueing network control policies with particular focus on combining stability with additional application-dependent requirements. Thereby, we consequently pursue a cost function based approach that provides the flexibility to incorporate constraints and requirements of particular services or applications. As typical examples of such requirements, we consider the reduction of buffer underflows in case of streaming traffic, and energy efficiency in networks of battery powered nodes. Compared with the classical throughput optimal control problem, such requirements significantly complicate the control problem. We provide easily verifiable theoretical conditions for stability, and, additionally, compare various candidate cost functions applied to wireless networks with streaming media traffic. Moreover, we demonstrate how the framework can be applied to the problem of energy efficient routing, and we demonstrate the application of our framework in cross-layer control problems for wireless multihop networks, using an advanced power control scheme for interference mitigation, based on successive convex approximation. In all scenarios, the performance of our control framework is evaluated using extensive numerical simulations.
Construction of a Biocompatible Decellularized Porcine Hepatic Lobe for Liver Bioengineering (2015)

We successfully developed a non-cytotoxic, non-immunogenic, and biodegradable porcine hepatic lobe for future liver regeneration and bioengineering.
Merosin (laminin‐2/4)‐driven survival signaling: Complex modulations of Bcl‐2 homologs (2003)

We have shown previously that the promotion of myofiber survival by the basement membrane component merosin (laminin-2 [alpha2beta1gamma1]/laminin-4 [alpha2beta2gamma1]) is dependent on the activity of the tyrosine kinase Fyn, whereas myofiber anoikis induced by merosin deficiency is dependent on the stress-activated protein kinase p38alpha. To further understand such merosin-driven survival signaling, we analyzed the expression of five Bcl-2 homologs (Bcl-2, Bcl-X(L), Bax, Bak, Bad) and one non-homologous associated molecule (Bag-1) in normal and merosin-deficient myotubes, with or without pharmacological inhibitors for Fyn and p38. Herein, we report that (1) merosin deficiency induces anoikis and causes decreased Bcl-2, Bcl-X(L), and Bag-1 levels, increased Bax and Bak levels, and decreased Bad phosphorylation; (2) Bcl-2, Bcl-X(L), Bag-1, and Bad phosphorylation are also decreased in anoikis-dying, Fyn-inhibited myotubes; (3) the inhibition of p38alpha in Fyn-inhibited and/or merosin-deficient myotubes protects against anoikis and increases Bcl-2 levels above normal, in addition to restoring Bad phosphorylation and Bag-1 levels to normal; (4) the overexpression of merosin in deficient myotubes also rescues from anoikis and increases Bcl-2 levels and Bad phosphorylation above normal, in addition to restoring Bcl-X(L), Bag-1, Bax, and Bak levels to normal; and (5) Bcl-2 overexpression is sufficient to rescue merosin-deficient myotubes from anoikis, even though the expression/phosphorylation levels of the other homologs analyzed are not restored to normal. These results indicate that merosin-driven myofiber survival signaling affects complex, differential modulations of individual Bcl-2 homologs. These further suggest that Bcl-2 can play a major role in suppressing myofiber anoikis.
Engineering a Therapeutic Lectin by Uncoupling Mitogenicity from Antiviral Activity (2020)

A key effector route of the Sugar Code involves lectins that exert crucial regulatory controls by targeting distinct cellular glycans. We demonstrate that a single amino acid substitution in a banana lectin, replacing histidine 84 with a threonine, significantly reduces its mitogenicity while preserving its broad-spectrum antiviral potency. X-ray crystallography, NMR spectroscopy, and glycocluster assays reveal that loss of mitogenicity is strongly correlated with loss of pi-pi stacking between aromatic amino acids H84 and Y83, which removes a wall separating two carbohydrate binding sites, thus diminishing multivalent interactions. On the other hand, monovalent interactions and antiviral activity are preserved by retaining other wild-type conformational features and possibly through unique contacts involving the T84 side chain. Through such fine-tuning, target selection and downstream effects of a lectin can be modulated so as to knock down one activity while preserving another, thus providing tools for therapeutics and for understanding the Sugar Code.
Involvement of Interleukin-10 (IL-10) and Viral IL-6 in the Spontaneous Growth of Kaposi’s Sarcoma Herpesvirus-Associated Infected Primary Effusion Lymphoma Cells (1999)

Primary effusion lymphoma (PEL) is a distinct type of lymphoma associated with Kaposi’s sarcoma-associated herpesvirus (KSHV) infection. To determine the factors responsible for the unrestrained proliferation of PEL, we have studied the growth factor requirements of the PEL-derived BCBL-1 and BC-1 cell lines. Both cell lines were found to be autocrine growth factor dependent and to release human interleukin-6 (IL-6), viral IL-6 (vIL-6), and human IL-10 in the culture supernatant. To establish whether these cytokines contribute to autocrine growth, neutralizing antibodies against human IL-6, vIL-6, human IL-10, and soluble IL-10 receptor were used. These experiments showed that human IL-10 and, to a lesser degree, vIL-6 serve as autocrine growth factors for BCBL-1 and BC-1 cells. Thus, human IL-10 and vIL-6 are growth factors released and used by PEL cells for autonomous proliferation and may be critical to the development and progression of PEL.
Molybdenum Oxide Nitrides of the Mo2(O,N,□)5 Type: On the Way to Mo2O5 (2017)

Blue-colored molybdenum oxide nitrides of the Mo<sub>2</sub>(O,N,□)<sub>5</sub> type were synthesized by direct nitridation of commercially available molybdenum trioxide with a mixture of gaseous ammonia and oxygen. Chemical composition, crystal structure, and stability of the obtained and hitherto unknown compounds are studied extensively. The average oxidation state of +5 for molybdenum is proven by Mo K near-edge X-ray absorption spectroscopy; the magnetic behavior is in agreement with compounds exhibiting Mo<sup>V</sup>O<sub>6</sub> units. The new materials are stable up to ∼773 K in an inert gas atmosphere. At higher temperatures, decomposition is observed. X-ray and neutron powder diffraction, electron diffraction, and high-resolution transmission electron microscopy reveal the structure to be related to VNb<sub>9</sub>O<sub>24.9</sub>-type phases, however, with severe disorder hampering full structure determination. Still, the results demonstrate the possibility of a future synthesis of the potential binary oxide Mo<sub>2</sub>O<sub>5</sub>. On the basis of these findings, a tentative suggestion on the crystal structure of the potential compound Mo<sub>2</sub>O<sub>5</sub>, backed by electronic-structure and phonon calculations from first principles, is given.
MMSE-based joint source and relay optimization for interference MIMO relay systems (2015)

In this paper, we investigate the transceiver design for amplify-and-forward (AF) interference multiple-input multiple-output (MIMO) relay communication systems when the direct links between the source and destination nodes are taken into consideration. The minimum mean-squared error (MMSE) of the signal waveform estimation at the destination nodes is chosen as the design criterion to optimize the source, relay, and receiver matrices for interference suppression. As the joint source, relay, and receiver optimization problem is nonconvex with matrix variables, a globally optimal solution is computationally intractable to obtain. We propose two iterative algorithms to provide computationally efficient solutions to the original problem through solving convex subproblems. These two algorithms provide efficient performance-complexity trade-off. Simulation results demonstrate that the proposed algorithms converge quickly after a few iterations and significantly outperform existing scheme in terms of the system bit error rate.
Molecular Basis for Oligomeric-DNA Binding and Episome Maintenance by KSHV LANA (2013)

LANA is the KSHV-encoded terminal repeat binding protein essential for viral replication and episome maintenance during latency. We have determined the X-ray crystal structure of LANA C-terminal DNA binding domain (LANADBD) to reveal its capacity to form a decameric ring with an exterior DNA binding surface. The dimeric core is structurally similar to EBV EBNA1 with an N-terminal arm that regulates DNA binding and is required for replication function. The oligomeric interface between LANA dimers is dispensable for single site DNA binding, but is required for cooperative DNA binding, replication function, and episome maintenance. We also identify a basic patch opposite of the DNA binding surface that is responsible for the interaction with BRD proteins and contributes to episome maintenance function. The structural features of LANADBD suggest a novel mechanism of episome maintenance through DNA-binding induced oligomeric assembly.
First Example of a Mixed Valence MnIIIMnIIMnIII Schiff-Base Polymeric Complex having a Trimeric Repeat Unit. Crystal Structure of [Mn3(HL)2(acetato)2(5-Cl-salicylato)2]n (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFirst Example of a Mixed Valence MnIIIMnIIMnIII Schiff-Base Polymeric Complex having a Trimeric Repeat Unit. Crystal Structure of [Mn3(HL)2(acetato)2(5-Cl-salicylato)2]nDora A. Malamatari, Panagiota Hitou, Antonis G. Hatzidimitriou, Frank E. Inscore, Andre Gourdon, Martin L. Kirk, and Dimitris P. KessissoglouCite this: Inorg. Chem. 1995, 34, 10, 2493–2494Publication Date (Print):May 1, 1995Publication History Published online1 May 2002Published inissue 1 May 1995https://pubs.acs.org/doi/10.1021/ic00114a002https://doi.org/10.1021/ic00114a002research-articleACS PublicationsRequest reuse permissionsArticle Views161Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Bethlem Myopathy in a Black Creole Pedigree (2002)

We report that Bethlem myopathy was linked to the collagen VIA1-2 region on chromosome 21q22.3 in a black Creole family. This is the first report of molecular-proven Bethlem myopathy in a family of either Creole or African-American descent. Although the correlation of Bethlem myopathy and keloids was not statistically significant, the possible connection between these two abnormalities raises the possibility of a common pathophysiological link involving collage VIA.
Superior Reactivity of Thiosemicarbazides in the Synthesis of 2‐Amino‐1,3,4‐oxadiazoles. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Effect of Sperm Viability, Plasmalemma Integrity, and Capacitation on Patterns of Expression of Mannose-Binding Sites on Human Sperm (1997)

The objective of this study was to characterize patterns of surface expression of mannose-binding sites (MBS) on human spermatozoa while evaluating the influence of sperm viability, plasma membrane integrity, and capacitation, D-Mannose binding sites were visualized by fluorescence microscopy using fluoresceinated mannose-enriched bovine serum albumin (FITC-DMA). To verify the probe specificity, 200 mM D-mannose and D-mannosylated albumin 200 micrograms/mL (DMA) were used as competitive inhibitors. Fluoresceinated bovine serum albumin (FITC-BSA) was used as control. Sperm membrane integrity was checked with a hypoosmotic swelling test (HOST) and sperm viability with Hoechst 33,258 at 1 microgram/mL. Viable spermatozoa with intact plasma membrane presented two main patterns: light bar (weak labeling of the equatorial segment) and slot (labeling of the pre- and postequatorial areas with a negative band in between). These patterns were significantly inhibited when unlabeled D-mannose or DMA were included in the medium. The percentages of spermatozoa displaying these two patterns increases significantly during capacitation. Nonviable spermatozoa with altered plasma membrane integrity presented multiple fluorescent patterns, all of which were present when FITC-BSA was used as the marker. None of them could be suppressed by unlabeled D-mannose or DMA. Viable spermatozoa displayed two main patterns which increased their incidence with capacitation and may be the only specific patterns for surface MBS. Other patterns detected in spermatozoa bearing altered plasma membranes may be due to nonspecific BSA binding or intracellular MBS recognition.
Basic Concepts of Supercapacitors (2017)

This chapter is aimed to provide a general description on the fundamental aspects regarding to supercapacitors (capacitors), which are important when developing new nanomaterials for such applications.
Harnessing endogenous growth factor activity modulates stem cell behavior (2011)

The influence of specific serum-borne biomolecules (e.g. heparin) on growth factor-dependent cell behavior is often difficult to elucidate in traditional cell culture due to the random, non-specific nature of biomolecule adsorption from serum. We hypothesized that chemically well-defined cell culture substrates could be used to study the influence of sequestered heparin on human mesenchymal stem cell (hMSC) behavior. Specifically, we used bio-inert self-assembled monolayers (SAMs) chemically modified with a bioinspired heparin-binding peptide (termed "HEPpep") and an integrin-binding peptide (RGDSP) as stem cell culture substrates. Our results demonstrate that purified heparin binds to HEPpep SAMs in a dose-dependent manner, and serum-borne heparin binds specifically and in a dose-dependent manner to HEPpep SAMs. These heparin-sequestering SAMs enhance hMSC proliferation by amplifying endogenous fibroblast growth factor (FGF) signaling, and enhance hMSC osteogenic differentiation by amplifying endogenous bone morphogenetic protein (BMP) signaling. The effects of heparin-sequestering are similar to the effects of supraphysiologic concentrations of recombinant FGF-2. hMSC phenotype is maintained over multiple population doublings on heparin-sequestering substrates in growth medium, while hMSC osteogenic differentiation is enhanced in a bone morphogenetic protein-dependent manner on the same substrates during culture in osteogenic induction medium. Together, these observations demonstrate that the influence of the substrate on stem cell phenotype is sensitive to the culture medium formulation. Our results also demonstrate that enhanced hMSC proliferation can be spatially localized by patterning the location of HEPpep on the substrate. Importantly, the use of chemically well-defined SAMs in this study eliminated the confounding factor of random, non-specific biomolecule adsorption, and identified serum-borne heparin as a key mediator of hMSC response to endogenous growth factors.
Metallurgical Design of Alloys for Aerospace Structures (2000)

New aluminum alloys for aircraft structures have been introduced recently. These new alloys are designed in such a way as to improve the weight efficiency of the structure. A good understanding of the loading of the different airframe parts is needed for this purpose. The present paper focuses on the micro-mechanical models which are used, or will be used, to find the optimum property balance. These models are based on microstructural features, which can be measured on the material or modeled by physical metallurgy equations. Examples are given for the typical rolled products used for the fabrication of an aircraft: thin sheets for fuselage application and plates for spars and ribs.
Schnelle Magnetresonanz-Bildgebung (2002)

Abstract in German Die Verkürzung der Untersuchungszeiten bei der klinischen Magnetresonanztomographie (MRT) bietet für den Patienten den Vorteil einer angenehmeren und schnelleren Untersuchung und erhöht gleichzeitig den Patientendurchsatz. Dies erfordert schnelle und robuste Aufnahmetechniken, welche beispielsweise auch bei der Aufnahme bewegter Organe oder für atemangehaltene Messungen eingesetzt werden können. Durch die Entwicklung leistungsfähiger Gradientensysteme konnten in den letzten Jahren neue und schnelle Pulssequenzen entwickelt werden. Die rasante Entwicklung neuer Aufnahmemethoden und Rekonstruktionstechniken macht es für den Anwender immer wichtiger, die grundlegenden Prinzipien schneller Aufnahmetechniken zu verstehen. In diesem Übersichtsartikel wird versucht, die Grundlagen der schnellen Pulssequenzen und deren klinische Anwendungsbereiche darzustellen. Dies beinhaltet die schnelle Spin-Echo-Technik und deren Kombination mit selektiven Präparationstechniken, die schnelle und ultraschnelle Gradienten-Echo-Technik sowie die echoplanare Bildgebung. Abschließend werden kurz neueste Entwicklungen wie die parallele Bildgebung beschrieben.Zusammenfassung auf S. 434
Real-Time Pore-Pressure Evaluation From MWD/LWD Measurements and Drilling-Derived Formation Strength (1991)

Summary Traditional pore-pressure interpretations in tertiary undercompacted shales have been based on empirical relationships between a particular measurement (such as resistivity) and pore pressure in pounds per gallon. It is well-known, however, that the measurements are responding to the "excess" porosity in the shale rather than to the pore pressure directly. A new technique is illustrated in which all available measurements are first characterized in terms of this excess porosity and lithology with measurement-response equations. This allows a mathematical minimization technique to solve simultaneously the various measurement-response equations for this porosity and lithology on a foot-by-foot basis. A conventional compaction porosity/effective-stress model is then used to determine the additional pore pressure caused by this excess porosity. The result is a single pore-pressure estimate that is independent of the number of measurements and that has an accuracy that improves with the total number of measurements used in the interpretation. The interpretation can be performed at the wellsite in real time by use of rate of penetration (ROP), measurement while drilling (MWD), and logging while drilling (LWD) measurements or after drilling by use of these measurements in conjunction with wireline measurements.