gebhart/patrepeval huggingface dataset:
Cereulide synthetase gene cluster from emetic : Structure and location on a mega virulence plasmid related to toxin plasmid pXO1-2 (2011)

<b>Copyright information:</b>Taken from "Cereulide synthetase gene cluster from emetic : Structure and location on a mega virulence plasmid related to toxin plasmid pXO1"BMC Microbiology 2006;6():20-20.Published online 2 Mar 2006PMCID:PMC1459170.Copyright © 2006 Ehling-Schulz et al; licensee BioMed Central Ltd.ted. Residues identical to amino acids from Ces core motifs are printed in boldface type. from CesA2 (D-Leu) and CesB1 (L--Val) were aligned to short chain dehydrogenases (SDR) and ketoreductases (KR); partial sequences including putative NADPH binding sites (solid bar) and the catalytic residues of SDRs/KR (printed in boldface type). Numbers between hyphens in the first lines refer to residues not shown before residues depicted in the second lines. JamL: KR from Jamaicamides synthetase (GenBank accession no. ) of ; EryA: KR from erythronolide synthetase of (GenBank accession no. ). GlcDh: Glucose 1-dehydrogenase from (Swissprot accession no. P39482).
Reductive Catalytic Depolymerization of Semi-industrial Wood-Based Lignin (2021)

The current work studies the reductive catalytic depolymerization (RCD) of lignin from a novel semi-industrial process. The aim was to obtain aromatic mono-, di-, tri-, and tetramers for further valorization. The substrate and products were characterized by multiple analytical methods, including high pressure size-exclusion chromatography (HPSEC), gas chromatography-mass spectrometry, GC-flame ionization detector (FID), GC-FID/thermal conductivity detector (TCD), and NMR. The RCD was studied by exploring the influence of different parameters, such as lignin solubility, reaction time, hydrogen pressure, reaction temperature, pH, type and loading of the catalyst, as well as type and composition of the organic/aqueous solvent. The results show that an elevated temperature, a redox catalyst, and a hydrogen atmosphere are essential for the depolymerization and stability of the products, while the reaction medium also plays an important role. The highest obtained mono- to tetramers yield was 98% and mono- to dimers yield over 85% in the liquid phase products. The reaction mechanisms influenced the structure of the aliphatic chain in the monomers, but left the phenolic structure along with the methoxy groups largely unaltered. The current work contributes to the development and debottlenecking of the novel and sustainable overall process, which utilizes efficiently all the fractions of wood, in line with the principles of green engineering and chemistry.
Vorinostat plus tacrolimus/methotrexate to prevent GVHD after myeloablative conditioning, unrelated donor HCT (2017)

Key Points Grade 2 to 4 acute GVHD in URD HCT patients who received vorinostat and tacrolimus/methotrexate after myeloablative conditioning was 22%. HDAC inhibition with vorinostat shows potential efficacy for GVHD prevention and should be investigated in a randomized phase 3 trial.
Signal spectrum analysis and period estimation by using delayed signal sampling (2002)

The paper describes a signal power spectrum analyzer and a period signal estimator whose bandwidth is not limited by the mean sampling time. The procedure relays on the evaluation of the input signal autocorrelation function in different delayed time instants, located at either equi-spaced or random time instants. To this, a recursive random sampling process in the time domain was used in order to avoid any bandwidth limitation due to the sampling strategy in the evaluation of each autocorrelation function. The signal power spectrum as well as its period, provided that an approximate value of the fundamental frequency is known, can finally be evaluated. Some theoretical background and experimental work is reported in the paper for validating the performance of the method.
Dosimetry on first clinical dark‐field chest radiography (2021)

The effective dose at the clinical dark-field radiography system, generating both attenuation and dark-field images, is within the range of reported standard dose values for chest radiography.
SP696COST EFFECTIVENESS OF BODY COMPOSITION MONITOR (FMC), FLUID MONITORING SYSTEM IN DIALYSIS PATIENTS FROM THE HEALTH CARE PAYER PERSPECTIVE (2019)

The literature shows differences between haemodialysis and peritoneal dialysis patient populations in terms of psychological characteristics and sociodemographic factors. Peritoneal dialysis patients tend to be younger, female and higher educated. However, the influence of the locus of control on modality choice has not been fully examined. One study found that haemodialysis patients have a stronger internal locus of control. The aim of this study was to investigate these differences. METHODS: In 2018, a nationwide postal survey was sent to dialysis patients of two sickness funds in Germany. Both ILC and ELC were measured by a 3-item short scale. On the 0-100 answer scale, high values indicate a strong ILC and a weak ELC. Furthermore, patients were asked to provide sociodemographic information. The sample was divided by whether they started with home-based peritoneal dialysis (PD) or in-centre haemodialysis (HD). Population differences in terms of ILC and ELC, as well as sociodemographic factors such as age, sex and school education, were examined. RESULTS: We included 651 dialysis patients in our analysis (HD=94%, PD=6%; 57% male, 43% female). The median age was 71 (22-94). The median ILC was higher with PD patients than with HD patients (HD=75, PD=83). Median ELC was similar in both groups (58). Hence, tests showed significant ILCdifferences in terms of HD and PD populations, but no significant differences in terms of ELC. With respect to sociodemographic factors, the patient populations varied only in age. The PD patients were significantly younger than the HD patients. There were no differences in school education or sex between modality groups. Testing the influence of the sociodemographic factors on ILC, we found that the differences in sex and school education were significant. Hence, they were controlled in a multifactorial logistic regression. In this model, both ILC and age had a significant influence on modality choice. CONCLUSIONS: In contrast to what was found in previous studies, HD and PD patients in our sample vary only in age, but not in sex and school education. This difference may be attributed to the specific characteristics of the two sickness funds we used in our sample. The results show that the effect of age and ILC remains significant and cannot be attributed to sex or education. Hence, younger patients and patients with a higher belief in internal control tend to choose PD. Younger patients often wish to remain able to work or travel. Furthermore, patients with a strong belief in their own control and skills are also confident in taking responsibility for their own treatment and managing their disease, as is the case with a home-based dialysis modality. This result contradicts the results of a previous study. In this study, the authors interpreted the higher ILC of HD patients as an indication of a stronger will to regulate their health condition being dependent on dialysis procedure. The direction of this correlation should be further examined. Nevertheless,
Overcoming Transit Time Limitations with Collective Excitations (2013)

Incorporating bi-layer electron and hole plasma, we produce a novel planar, top illuminated photodetector with time response of &lt; 2.5 ps sensitive to fraction of μW optical power, and capable of operation without applied bias.
Directed assembly of gold nanorods using aligned electrospun polymer nanofibers for highly efficient SERS substrates (2011)

Nonspherical metal nanoparticles are very attractive plasmonic nanostructures owing to the facile tunability of the plasmonic properties and the presence of sharp corners and edges, which act as electromagnetic hot spots for surface enhanced Raman scattering (SERS). However, such anisotropic nanostructures exhibit strong polarization dependence in their plasmonic properties, exhibiting significantly higher SERS intensity in certain orientations. In this paper, we demonstrate a facile strategy to achieve directed assembly of aligned gold nanorods using highly aligned electrospun nanofibers. We believe that the interstices between the nanofibers act as micro-and nanochannels, resulting in hydrodynamic drag forces on the gold nanorods, thus inducing massive alignment of the same on the nanofibers. Apart from exhibiting nearly 50 times higher SERS intensity compared to a planar SERS substrate with randomly oriented nanorods, our results highlight the importance of the orientation of anisotropic nanostructures. Finite difference time domain (FDTD) simulations employed to understand the electromagnetic field distribution around an aligned nanorod array showed excellent agreement with the experimental observations.
Mutual polarization of monomer charge distribution in (HCN)2, (HCN)3, and (HCN)∞ (1991)

A simple classical mutual polarization model accurately predicts the induced dipole moments of linear HCN dimer and trimer. The model employs the first four nonzero electrical molecular moments of each HCN, and both the molecular polarizability and the C–H and C–N bond dipole polarizabilities. The model is extended to linear H-bonded oligomers up to the pentamer, and also to an infinite linear H-bonded chain, appropriate for comparison with the H-bonded chains present in the HCN crystal. For the dimer and trimer, a relation is seen between the change in the electric field gradient at the N of HCN and the calculated induced C–N bond dipole moment. A semiquantitative proportionality constant, derived based on this relation, is used to enhance understanding of the underlying cause of the large increase in the 14N quadrupole coupling constant in the HCN crystal relative to the free HCN monomer. This increase results from the strong polarization of the C–N bond by the local field at each HCN caused by the rest of the HCN crystal lattice.
Inhibition of SARS-CoV-2 Omicron BA.1 and BA.4 Variants After Fourth Vaccination or Tixagevimab and Cilgavimab Administration in Patients With Cancer (2022)

This cohort study assesses the capacity of passive immunization and tixagevimab and cilgavimab to inhibit interaction between receptor-binding domains and angiotensin-converting enzyme 2 in patients with hemato-oncologic diseases.
Design of a novel elliptical skin biopsy punch device (2009)

Current skin biopsy techniques utilizing a punch biopsy device can leave raised scars that are cosmetically unappealing. With 3.8 million procedures per year, the potential marketability of a superior device is substantial. The goal of this study is to design a novel elliptical punch biopsy device that maintains the simplicity of existing products while minimizing scarring. Mechanical testing was performed on porcine skin to determine the force required to breach the dermal layer using a single #11 scalpel blade (comparable to the excision biopsy technique), the traditional biopsy punch, and a novel blade design. The force required to penetrate the skin using the novel design (81.72 N) prototype was considerably higher than the single #11 blade (1.89 N-2.42 N) as well as the punch biopsy (4.61 N). Initial force data and mathematical analysis has resulted in a final blade design that requires less force than the initial prototype and includes fail-safes to prevent excessive depth of penetration. Clinicians will ultimately test these devices, and their feedback will be used to create a final production design. Finally, a proposed mass manufacturing technique was created.
Technical damage analysis of a mechanical seal based on thermal waves and correlated with EDX and SEM (1999)

A seal which had been in contact with sea water of high salt concentration, has been analysed, in order to characterize the erosion effects and throw light on the erosion mechanisms. The measured effective thermal depth profiles have been interpreted phenomenologically and have been correlated with energy-dispersive X-ray microanalysis (EDX) and scanning electron microscopy (SEM).
Potential mechanisms of attenuation for rifampicin-passaged strains of Flavobacterium psychrophilum (2015)

Multiple genomic changes arose during passage experiments with rifampicin selection pressure. Consistent with our hypothesis, unique strain-specific mutations were detected for the fully attenuated (CR), partially attenuated (CN) and another fully attenuated strain (B17).
Trends, Advances and Prospects of Optical Imaging in Germany and Beyond (2016)

High wage industrial countries like Germany face a number of unique challenges, like the demographic change, globalization, and the need for a constant technological competitive edge. Optical imaging is a key technology to address these challenges. Lithography for example is one of the core technologies in the production of integrated circuits as well as camera chips and displays. This drives an abundant computational capacity giving rise to other technologies like computational imaging, machine learning, big data analysis and virtual/augmented reality. The resulting digitalization of optics in turn pushes miniaturized optics ranging from smartphone cameras, to microoptics, down to plasmonics and metamaterials. On system side the trend to lightfield-imaging, 3D-imaging and multimodal imaging continues and finds applications in research and healthcare. For that high imaging speed and large fields are key. The German academic and industrial landscape, in this regard, will be addressed, too.
Test stand for the Silicon Vertex Detector of the Collider Detector Facility (1996)

A test stand for the next generation of the Silicon Vertex Detector (SVX-II) of the Collider Detector Facility (CDF) at Fermilab has been developed. It is capable of performing cosmic ray, beam, and laser pulsing tests on silicon strip detectors using the new generation of SVX chips. The test stand is composed of a SGI workstation, a VME CPU, the Silicon Test Acquisition and Readout (STAR) board, the Test Fiber Interface Board (TFIB), and the Test Port Card (TPC). The STAR mediates between external stimuli for the different tests and produces appropriate high level commands which are sent to the TFIB. The TFIB, in conjunction with the TPC, translates these commands into the correct logic levels to control the SVX chips. The four modes of operation of the SVX chips are configuration, data acquisition, digitization, and data readout. The data read out from the SVX chips is transferred to the STAR. The STAR can then be accessed by the VME CPU and the SGI workstation for future analyses. The detailed description of this test stand will be given.
Preliminary analysis of the Cryptosporidium muris genome. (2009)

In 1999, the National Institute of Health (NIH) recognized the importance of sequencing the genome of Cryptosporidium parvum and Cryptosporidium hominis as a means of addressing the urgent need to better understand these human parasites and identify potential drug targets. Although the genome sequences of these species are providing useful information for understanding their biology and their interaction with host cells, the high degree of similarity between the C. parvum and C. hominis genomes limits the usefulness of comparative methods. C. muris is not an important human pathogen per se, but due to its evolutionary distance to the human parasites, sequencing the C. muris genome will enhance the scientific value of the existing Cryptosporidium genome sequences. We report here on the progress with the C. muris genome project, and a preliminary analysis of the genome of this parasite. Based on a preliminary sequence assembly, the size of the C. muris genome is estimated at 8.7-9.3 Mbp with a 28.6% GC content.
Blockade of VEGF-C and VEGF-D modulates adipose tissue inflammation and improves metabolic parameters under high-fat diet (2014)

These results reveal an unanticipated role of the lymphangiogenic factors VEGF-C and -D in the mediation of metabolic syndrome-associated adipose tissue inflammation. Blockage of these lymphangiogenic factors might constitute a new therapeutic strategy for the prevention of obesity-associated insulin resistance.
Combined overexpression of genes of the ergosterol biosynthetic pathway leads to accumulation of sterols in (2003)

Genes of the post-squalene ergosterol biosynthetic pathway in Saccharomyces cerevisiae have been overexpressed in a systematic approach with the aim to construct yeast strains that produce high amounts of sterols from a squalene-accumulating strain. This strain had previously been deregulated by overexpressing a truncated HMG-CoA reductase (tHMG1) in the main bottleneck of the early ergosterol pathway. The overexpression of the gene ERG1 (squalene epoxidase) induced a significant decrease of the direct substrate squalene, a high increase of lanosterol, and a small increase of later sterols. The overexpression of the ERG11 gene encoding the sterol-14alpha-demethylase resulted in a decrease of lanosterol and an increase of downstream sterols. When these two genes were simultaneously overexpressed, later sterols from zymosterol to ergosterol accumulated and the content of squalene was decreased about three-fold, indicating that these steps had limited the transformation of squalene into sterols. The total sterol content in this strain was three-fold higher than in a wild-type strain.
1823: Epha2: A Novel Target for Prostate Cancer Treatment (2004)

You have accessJournal of UrologyDiscussed Poster, Wednesday, May 12, 2004, 8:00 am - 12:00 pm1 Apr 20041823: Epha2: A Novel Target for Prostate Cancer Treatment Gordon Zeng, Zhiqiang Hu, Shaobo Zhang, Lang Li, LeeAnn Baldridge, Chinghai Kao, Thomas A. Gardner, Michael O. Koch, Thomas M. Ulbright, John N. Eble, and Liang Cheng Gordon ZengGordon Zeng More articles by this author , Zhiqiang HuZhiqiang Hu More articles by this author , Shaobo ZhangShaobo Zhang More articles by this author , Lang LiLang Li More articles by this author , LeeAnn BaldridgeLeeAnn Baldridge More articles by this author , Chinghai KaoChinghai Kao More articles by this author , Thomas A. GardnerThomas A. Gardner More articles by this author , Michael O. KochMichael O. Koch More articles by this author , Thomas M. UlbrightThomas M. Ulbright More articles by this author , John N. EbleJohn N. Eble More articles by this author , and Liang ChengLiang Cheng More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)39015-3AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "1823: Epha2: A Novel Target for Prostate Cancer Treatment." The Journal of Urology, 171(4S), p. 482 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 171Issue 4SApril 2004Page: 482 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Gordon Zeng More articles by this author Zhiqiang Hu More articles by this author Shaobo Zhang More articles by this author Lang Li More articles by this author LeeAnn Baldridge More articles by this author Chinghai Kao More articles by this author Thomas A. Gardner More articles by this author Michael O. Koch More articles by this author Thomas M. Ulbright More articles by this author John N. Eble More articles by this author Liang Cheng More articles by this author Expand All Advertisement PDF downloadLoading ...
Evaluation of Clostridium septicum hemolytic activity, administration route, and dosage volume of a clostridial dermatitis (cellulitis) bacterin-toxoid on humoral immune response in commercial turkeys (2023)

Clostridial cellulitis or dermatitis affects commercial turkey flocks, primarily as they approach market age. In the field, this disease has been effectively controlled with antibiotics, but alternatives to antibiotics are needed. Bacterin-toxoid vaccination programs have been shown to prevent clostridial diseases in other species, including humans. Results from previous field studies indicate that vaccination with an experimental whole-cell Clostridium septicum (CS) bacterin-toxoid oil emulsion vaccine reduced clostridial dermatitis-associated mortality and antibiotic usage for some commercial turkey flocks, but vaccination was not always efficacious. To improve vaccine efficacy, studies were conducted to optimize the antigenic component of the experimental vaccine and to determine the appropriate antigen to adjuvant ratio, route, and volume for vaccine administration. It was determined that the phase of culture at time of formalin inactivation played a key role in serum antibody titer and larger volume vaccine doses produced higher serum antibody immune response regardless of antigen:adjuvant formulation ratio or route of injection. No significant differences (P > 0.05) were found between formulation ratios or between the subcutaneous and tail head injection sites. Based on these results, we propose to look further into the relationship between culture phase and antigenic components produced by CS under different culture conditions.
Long-Wave-Infrared Integrated Photonics with Germanium-on-Silicon Waveguides (2021)

We describe propagation loss, ring resonance, and thermo-optics in germanium-on-silicon (GOS) waveguides throughout the long-wave-infrared. These measurements show the potential of this platform for photonic integration at wavelengths from 7 microns to beyond 11 microns.
Tradeoffs between false sharing and aggregation in software distributed shared memory (1997)

Software Distributed Shared Memory (DSM) systems based on virtual memory techniques traditionally use the hardware page as the consistency unit. The large size of the hardware page is considered to be a performance bottleneck because of the implied false sharing overheads. Instead, we show that in the presence of a relaxed consistency model and a multiple writer protocol, a large consistency unit is generally not detrimental to performance. We study the tradeoffs between false sharing and aggregation effects when using large consistency units. In this context, this paper makes three separate contributions:1. We document the cost of false sharing in terms of extra messages and extra data being communicated. We find that, for the applications considered, when the virtual memory page is used as the consistency unit, the number of extra messages is small, while the amount of extra data can be substantial.2. We evaluate the performance when the consistency unit is increased to a multiple of the virtual memory page size. For most applications and data sets, the performance improves, except when the false sharing effects include extra messages or a large amount of extra data.3. We present a new algorithm for dynamically aggregating pages. In our algorithm, the aggregated pages do not necessarily need to be contiguous. In all cases, the performance of our dynamic aggregation algorithm is similar to that achieved with the best static page size.These results were obtained by measuring the performance of eight applications on the TreadMarks distributed shared memory system. The hardware platform used is a network of 166Mhz Pentiums connected by a switched 100Mbps Ethernet network.