gebhart/patrepeval huggingface dataset:
Separability of spatial manipulations in multi-touch interfaces (2009)

Multi-touch interfaces allow users to translate, rotate, and scale digital objects in a single interaction. However, this freedom represents a problem when users intend to perform only a subset of manipulations. A user trying to scale an object in a print layout program, for example, might find that the object was also slightly translated and rotated, interfering with what was already carefully laid out earlier. We implemented and tested interaction techniques that allow users to select a subset of manipulations. Magnitude Filtering eliminates transformations (e.g., rotation) that are small in magnitude. Gesture Matching attempts to classify the user’s input into a subset of manipulation gestures. Handles adopts a conventional single-touch handles approach for touch input. Our empirical study showed that these techniques significantly reduce errors in
Identification of Distinct Inflammatory Programs and Biomarkers in Systemic Juvenile Idiopathic Arthritis and Related Lung Disease by Serum Proteome Analysis (2022)

Serum proteins support a systemic JIA-to-MAS continuum; help distinguish systemic JIA, systemic JIA/MAS, and SJIA-LD; and suggest etiologic hypotheses. Select biomarkers, such as ICAM-5, could aid in early detection and management of SJIA-LD.
Binding of the O-antigen of Shigella dysenteriae type 1 and 26 related synthetic fragments to a monoclonal IgM antibody. (1993)

Shigella dysenteriae type 1 possesses an O-antigen whose repeating unit is -->3)-alpha-L-Rhap-(1-->3)-alpha-L-Rhap-(1-->2)-alpha-D-Galp -(1-->3)-alpha-D- GlcpNAc-(1-->, where Rhap is rhamnopyranosyl, Galp is galactopyranosyl, and Glcp is glucopyranosyl. Using ligand-induced protein fluorescence change, we have measured the affinities of a monoclonal murine IgM for 26 fragments of, or related to, the structure of the O-polysaccharide and of the IgM Fab for the intact O-specific bacterial polysaccharide. Synthetic saccharides used were methyl glycosides to ensure an anomerically defined pyranosyl ring conformation. The galactosyl residue is the only monosaccharide of the antigenic epitope that shows quantifiable binding: approximately 3.0 kcal/mol of binding free energy, depending on the structure and conformation of the fragment it is a part of. Addition of an alpha-(1-->2)-linked rhamnosyl residue increases the free energy of binding significantly. We propose this rhamnopyranosyl-alpha-(1-->2)-galactopyranosyl disaccharide to be the basic determinant of the Shigella O-polysaccharide. Further extension (by linkages as in the natural antigen) of this oligosaccharidic ligand toward the upstream end (in an oligo- (or poly-)saccharide, such as A-->B-->C-->D-->E-->m, where A, B, C, D, and E are sugars and m is any moiety, such as methyl, we define A as the glycosyl- or upstream terminus, and E as the glycoside- or downstream terminus) by rhamnosyl and N-acetylglucosaminyl moieties improves the binding only minimally. The antibody is quite specific for the rhamnosyl-alpha-(1-->2)-galactosyl sequence but less so for the nature of the attachment to the galactosyl residue on the downstream side. Measurements using IgM Fab and the intact O-specific polysaccharide show that the antibody can bind internal segments on the antigen chain. The free energy of binding of this antibody for the disaccharide determinant varies from -delta G of 4.7 to 5.1 kcal/mol, depending on its flanking residues.
Narrow Molecular Weight Distribution Precursors for Polymer-Drug Conjugates (2001)

Die Atomtransfer-Polymerisation diente zur Synthese von Aktivester-Homopolymeren mit enger Molekulargewichtsverteilung, die als Vorstufen zur Herstellung von Polymer-Wirkstoff-Konjugaten im Rahmen vorklinischer Untersuchungen eingesetzt wurden (siehe schematische Darstellung).
Evolution of Iron(II)‐Finger Peptides by Using a Bipyridyl Amino Acid (2014)

We report the engineering of zinc-finger-like motifs containing the unnatural amino acid (2,2'-bipyridin-5-yl)alanine (Bpy-Ala). A phage-display library was constructed in which five residues in the N-terminal finger of zif268 were randomized to include both canonical amino acids and Bpy-Ala. Panning of this library against a nine-base-pair DNA binding site identified several Bpy-Ala-containing functional Zif268 mutants. These mutants bind the Zif268 recognition site with affinities comparable to that of the wild-type protein. Further characterization indicated that the mutant fingers bind low-spin Fe(II) rather than Zn(II) . This work demonstrates that an expanded genetic code can lead to new metal ion binding motifs that can serve as structural, catalytic, or regulatory elements in proteins.
Rate-Distortion Optimization in Dynamic Mesh Compression (2006)

Recent developments in the compression of dynamic meshes or mesh sequences have shown that the statistical dependencies within a mesh sequence can be exploited well by predictive coding approaches. Coders introduced so far use experimentally determined or heuristic thresholds for tuning the algorithms. In video coding rate-distortion (RD) optimization is often used to avoid fixing of thresholds and to select a coding mode. We applied these ideas and present here an RD-optimized mesh coder. It includes different prediction modes as well as an RD cost computation that controls the mode selection across all possible spatial partitions of a mesh to find the clustering structure together with the associated prediction modes. The structure of the RD-optimized D3DMC coder is presented, followed by comparative results with mesh sequences at different resolutions.
Dual mTORC1/2 and HER2 Blockade Results in Antitumor Activity in Preclinical Models of Breast Cancer Resistant to Anti-HER2 Therapy (2012)

The simultaneous blockade of both PI3K/Akt/mTOR and ERK pathways obtained by combining lapatinib with INK-128 acts synergistically in inducing cell death and tumor regression in breast cancer models refractory to anti-HER2 therapy.
Cell-mediated lympholytic responses against autologous cells modified with haptenic sulfhydryl reagents. V. H-2Ld self products are recognized by anti-AED-specific cytotoxic T cells. (1983)

The present studies were designed to examine the restriction elements involved in the H-2d haplotype CTL response against AED-self. BALB/c mice were immunized by in vivo administration of syngeneic BALB/c spleen cells conjugated with the sulfhydryl reactive haptenic reagent I-AEDANS. The cytotoxic T cell response generated by subsequent in vitro stimulation with AED-self was found to contain H-2K and H-2D region-specific components. In contrast to the predominant H-2D hapten-self CTL responses induced by amino-reactive haptenic reagents like TNBS and FITC, the AED-self response was predominantly directed against H-2K self products. Antibody inhibition analysis demonstrated that the H-2D region component contained Ld-AED-self CTL, as well as Dd-AED-self CTL. However, although both Ld- and Dd-restricted components could be identified shortly (less than 1 wk) after priming, the H-2D region AED-self CTL response shifted to a single restricting molecule, namely Dd, 1 wk and later after immunization. The results of this study provide the first demonstration that the H-2L locus encodes a cell surface product that can function as a restricting molecule for hapten-self-specific CTL. The shift from Ld and Dd AED-specific CTL to Dd only suggests the existence of a highly specific regulatory mechanism directed against antigen (i.e., hapten) plus self.
Characterisation of a surrogate Type-II alveolar cell culture model for ATP binding cassette subfamily a member 3 (ABCA-3) deficiency (2020)

Introduction/Aim. ATP Binding Cassette Subfamily A Member 3 (ABCA-3) is a lipid transporter protein highly expressed in type-II alveolar (AT-II) cells. Mutations in ABCA3 can result in severe respiratory disease in infants and children. Cell cultures derived from patients with ABCA-3 deficiency that reflect the genetic and phenotypic features of ABCA-3 associated lung disease, would provide a means to study disease mechanisms and investigate therapeutics. Primary AT-II cells, while physiologically relevant to ABCA-3 deficiency, are not generally accessible. ABCA-3 is present in the nasopharynx, hence primary nasal epithelial cells could potentially provide a more accessible cell culture model. Our aim was to investigate the suitability of nasal epithelial cells to study ABCA-3 deficiency. &#13;\n&#13;\nMethods. Expression of ABCA3, and AT-II cell markers, SFTPB and SFTPC, in nasal epithelial cells and primary AT-II cells, were quantified by droplet digital PCR. Protein localisation of ABCA-3 was visualised by immunofluorescent microscopy. Functionality of the ABCA-3 protein in nasal epithelial cells derived from human subjects with or without ABCA-3 deficiency was assessed by the capacity of the cells to detoxify doxorubicin. &#13;\n&#13;\nResults. While ABCA-3 protein was localised in the cytoplasm of primary nasal epithelial cells, mRNA levels were 6.35x103-fold lower in nasal epithelial cells compared to primary AT-II cells. Gene expression of SFTPB and SFTPC was also significantly lower by 5.26 x 106- and 5.36 x 106-fold, respectively. Higher concentrations of doxorubicin reduced cell viability in ABCA-3 deficient nasal epithelial cells compared to controls in an assay-dependent manner when using an MTS assay but not with a lactate dehydrogenase assay or by calcein blue staining. &#13;\n&#13;\nConclusion. There may be a role for nasal epithelial cell cultures to model ABCA-3 deficiency depending on endpoints of interest. However, alternative approaches that more accurately replicate the AT-II phenotype need to be explored.
Using the Wave Variable Method for a Human-Machine Haptic Interface in the Presence of Time Delay (2023)

Even a small amount of time delay in a bilateral teleoperation system will generally degrade the system's performance and cause instability. Consequently, without some form of compensation for time delay, latencies in a teleoperation system would preclude the use of force feedback. Fortunately, there are approaches based on scattering theory and passivity that can compensate for time delay and allow the use of force feedback in teleoperation systems with latencies. In particular, the wave variable method is a passivity- based approach that guarantees stability for any fixed time delay. In this work, the authors take a generalized approach which includes the complete family of scaling matrices. This extended family of scaling matrices is used in an experiment with human subjects and a PHANToM Omni haptic teleoperation system. The experiment will compare the raw data with the users' opinions in order to determine the best set of scaling matrices for the given task.
Geospatially-resolved public-health surveillance via wastewater sequencing (2023)

Wastewater, which contains everything from pathogens to pollutants, is a geospatially-and temporally-linked microbial fingerprint of a given population. As a result, it can be leveraged for monitoring multiple dimensions of public health across locales and time. Here, we integrate targeted and bulk RNA sequencing (n=1,419 samples) to track the viral, bacterial, and functional content over geospatially distinct areas within Miami Dade County from 2020-2022. First, we used targeted amplicon sequencing (n=966) to track diverse SARS-CoV-2 variants across space and time, and we found a tight correspondence with clinical caseloads from University students (N = 1,503) and Miami-Dade County hospital patients (N = 3,939 patients), as well as an 8-day earlier detection of the Delta variant in wastewater vs. in patients. Additionally, in 453 metatranscriptomic samples, we demonstrate that different wastewater sampling locations have clinically and public-health-relevant microbiota that vary as a function of the size of the human population they represent. Through assembly, alignment-based, and phylogenetic approaches, we also detect multiple clinically important viruses (e.g., <i>norovirus</i> ) and describe geospatial and temporal variation in microbial functional genes that indicate the presence of pollutants. Moreover, we found distinct profiles of antimicrobial resistance (AMR) genes and virulence factors across campus buildings, dorms, and hospitals, with hospital wastewater containing a significant increase in AMR abundance. Overall, this effort lays the groundwork for systematic characterization of wastewater to improve public health decision making and a broad platform to detect emerging pathogens.
Ellipse-line-ellipse source trajectory and its R-line coverage for long-object cone-beam imaging with a C-arm system (2012)

Over the last decade, significant progress has been made in terms of treatment of diseases using minimallyinvasive procedures. This progress was facilitated through multiple refinements of the imaging capabilities of C-arm systems in the interventional room, and more sophisticated procedures may become feasible by further refining the performance of these systems. Our primary focus is to eliminate two strong limitations of the current circular cone-beam imaging approach: cone-beam artifacts and limited extent of the volume covered in the direction of the patient bed. To solve this problem, we seek a source trajectory that (i) is complete in terms of Tuy's condition, (ii) can be periodically-repeated without discontinuities to allow long-object imaging, (iii) is practical, and (iv) offers full R-line coverage (an R-line is a line that connects any two source positions). A trajectory that satisfies all of our constraint is the Arc-Extended-Line-Arc(AELA) trajectory. Unfortunately, this trajectory does not allow smooth, continuous scanning at reasonable dose. In this work, we propose a new data acquisition geometry: the Ellipse-Line-Ellipse (ELE) trajectory. This geometry satisfies all of our constraints along with the attractive feature that smooth, continuous scanning at reasonable dose is enabled.
A highly regular and scalable aes hardware architecture (2003)

This article presents a highly regular and scalable AES hardware architecture, suited for full-custom as well as for semicustom design flows. Contrary to other publications, a complete architecture (even including CBC mode) that is scalable in terms of throughput and in terms of the used key size is described. Similarities of encryption and decryption are utilized to provide a high level of performance using only a relatively small area (10,799 gate equivalents for the standard configuration). This performance is reached by balancing the combinational paths of the design. No other published AES hardware architecture provides similar balancing or a comparable regularity. Implementations of the fastest configuration of the architecture provide a throughput of 241 Mbits/sec on a 0.6 /spl mu/m CMOS process using standard cells.
Volcanotectonics: the tectonics and physics of volcanoes and their eruption mechanics (2022)

Abstract The physical processes that operate within, and beneath, a volcano control the frequency, duration, location and size of volcanic eruptions. Volcanotectonics focuses on such processes, combining techniques, data, and ideas from structural geology, tectonics, volcano deformation, physical volcanology, seismology, petrology, rock and fracture mechanics and classical physics. A central aim of volcanotectonics is to provide sufficient understanding of the internal processes in volcanoes so that, when combined with monitoring data, reliable forecasting of eruptions, vertical (caldera) and lateral (landslide) collapses and related events becomes possible. To gain such an understanding requires knowledge of the material properties of the magma and the crustal rocks, as well as the associated stress fields, and their evolution. The local stress field depends on the properties of the layers that constitute the volcano and, in particular, the geometric development of its shallow magma chamber. During this decade an increasing use of data from InSAR, pixel offset and structure-from-motion, as well as dense, portable seismic networks will provide further details on the mechanisms of volcanic unrest, magma-chamber rupture, the propagation of magma-filled fractures (dikes, inclined sheets and sills) and lateral and vertical collapse. Additionally, more use will be made of accurate quantitative data from fossil and active volcanoes, combined with realistic numerical, analytical and machine-learning studies, so as to provide reliable models on volcano behaviour and eruption forecasting.
AlxGa1-xAs Heterojunction Phototransistors Responding to Entire Visible Wavelength Region (1992)

An Al x Ga 1- x As heterojunction phototransistor, in which an incident light directly reaches the base through an opening at the center of the emitter layer, is proposed and fabricated. The phototransistor exhibits photosensitivity over a wide spectral region from 380 to 870 nm. The optical conversion gains, G =520 at 515 nm wavelength and G =950 at 730 nm, are obtained. The opening at the emitter layer influences the characteristics of the devices and this is discussed in terms of the surface recombination and emitter current crowding. The device can serve as a photodetector with optical conversion gain over a wide wavelength region.
Treatment of hepatitis C-virus-reinfection after liver transplant with silibinin in nonresponders to pegylated interferon-based therapy. (2011)

Intravenous silibinin is an effective therapeutic approach for treating hepatitis C-virus-reinfection after liver transplant and should be evaluated further.
Crowdsensing-Based Personalized Dynamic Route Planning for Smart Vehicles (2020)

Current route planning systems report to the driver routes based on expected travel time and distance. However, these systems do not provide individualized routing options. With the current routing systems lacking the provision of individualized routing choices, a routing framework which provides a personalized route option not solely based on time and distance would be a step up. With the expanding sensing and computing capabilities in both vehicles and smart devices along with the promising low-latency of 5G networks, a real-time personalized route planner is achievable. In this article, a route planning framework that utilizes the in-vehicle and smartphone sensors to build a crowdsensed database on road surface quality and the driver's personalized skillfulness in different driving environments is proposed. Such databases are leveraged to provide drivers with routing options based on their personal preferences. This framework is tested and validated through a case study of a real driving scenario in Kingston, Ontario to show the framework capabilities compared to conventional route planning.
Effects of Joint Loading on Articular Cartilage Collagen Metabolism: Assay of Procollagen Prolyl 4-Hydroxylase and Galactosylhydroxylysyl Glucosyltransferase (1988)

The degree of joint loading on the femoral head cartilage was experimentally altered in dogs by splinting of the knee joint for 11 weeks (n = 9), and making another group (n = 6) to run on a treadmill with 15 degrees uphill inclination during a period of 15 weeks (4 km/day, 5 days a week). A third group (n = 9) served as controls. The influence of these altered loading conditions on articular cartilage collagen synthesis was measured by assaying the activity of procollagen prolyl 4-hydroxylase (PPH) and galactosylhydroxylysyl glucosyltransferase (GGT) in chondrocytes. The average activity of PPH was 11-13% elevated in the runner and contralateral (more loaded) cartilages, while the splinted (unloaded) cartilages showed a significant (53%) increase of PPH. In some samples of the runner, splinted and contralateral cartilages the activity of GGT was also high, but the differences did not reach statistical significance. The increase of the activity of PPH, combined with unaltered total content of collagen, indicates that the synthesis of collagen and probably also its turnover, are enhanced in the cartilage atrophied due to reduced weight-bearing, but only slightly, if at all in the cartilages subjected to moderately elevated loading.
Catalytic Reductive Coupling of Epoxides and Aldehydes: Epoxide‐Ring Opening Precedes Carbonyl Reduction. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Quantum Well and Dot Self-Aligned Stripe Lasers Utilizing an InGaP Optoelectronic Confinement Layer (2009)

We demonstrate and study a novel process for fabrication of GaAs-based self-aligned lasers based upon a single overgrowth. A lattice-matched n-doped InGaP layer is utilized for both electrical and optical confinements. Single-lateral-mode emission is demonstrated initially from an In <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.17</sub> Ga <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.83</sub> As double quantum well laser emitting ~980 nm. We then apply the fabrication technique to a quantum dot laser emitting ~1300 nm. Furthermore, we analyze the breakdown mechanism in our devices and discuss the limitations of index guiding in our structures.
Heterogeneous Integration on Silicon (2014)

Aurrion’s heterogeneous integration process enables high performance active components such as lasers, modulators, and photodetectors to be elegantly integrated on a silicon photonics platform with high performance passive components.
Finding Genes and Mutations (1999)

In this chapter the authors describe the sorts of DNA analyses that can be done to detect genomic changes with present technology. They extrapolate to see what improvements will be likely in the future.
Enhancement of magnetoresistance by Zn w&uuml;stite spin-filtering layer (2012)

We have investigated a new magnetic material composed of ultra-thin oxide spin-filtering layer (SFL)/ferromagnetic layer (FML) for magnetoresistance (MR) enhancement. By inserting Zn-Fe oxide as a SFL material in current-perpendicular-to-plane giant magnetoresistive (CPP-GMR) films, the MR ratio and ΔRA (the change of resistance area product) were enhanced to 26.0% and 52 mΩμm2 at a small RA (resistance area product) of about 0.2 mΩμm2, respectively. Structural analysis revealed that the Zn wüstite structure is responsible for the enhancement of the MR ratio, and wüstite/FML structure has higher spin-polarization than that for spinel ferrite/FML. Although wüstite has not been predicted to be high spin-polarization material and little experimental data on the transport property has been reported, our results indicate that wüstite has potential as high spin-polarization material for future spin electronics.
Edward Allen (ed.). Forms of Late Modernist Lyric (2022)

‘Capitalism’, as some wag observed of Ernest Mandel’s Late Capitalism, ‘will never be “late” until it is dead’. Something along the same lines might be said of the Modernist lyric, the irrelevance or even demise of which was long declared by poetry officialdom, but which never seemed to go away, and is today more obstreperously present than at any time in almost a century. In what was the dominant narrative from the 1950s to the 1990s, the ‘High Modernism’ of the 1920s, with its formalist concerns, ended in 1930, or 1939, or 1945 depending on preference. A poetry cross-link was cobbled together to take ‘the English tradition’ (to use Donald Davies’s revealing definite article) around the aberrational epicentre of The Waste Land, by gluing together Hardy, Edward Thomas, post-Orators Auden, Keith Douglas, Larkin, Hughes-Hill-Gunn, Ulster Poets and Martians or whatever else was needed to shore up the ruins of ruptured continuity. The odd ‘maverick’ was homeopathically included but that was about it. Nothing to see here, folks, move along.