gebhart/patrepeval huggingface dataset:
Catalytic, Asymmetric Synthesis of the Carbacephem Framework (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCatalytic, Asymmetric Synthesis of the Carbacephem FrameworkPeter R. Guzzo and Marvin J. MillerCite this: J. Org. Chem. 1994, 59, 17, 4862–4867Publication Date (Print):August 1, 1994Publication History Published online1 May 2002Published inissue 1 August 1994https://pubs.acs.org/doi/10.1021/jo00096a031https://doi.org/10.1021/jo00096a031research-articleACS PublicationsRequest reuse permissionsArticle Views706Altmetric-Citations45LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Long-term infusion of anti-GD2 antibody ch14.18/CHO in combination with interleukin-2 (IL2) activity and efficacy in high-risk relapsed/refractory neuroblastoma patients. (2015)

TPS10080 Background: Long-term infusion (LTI) of anti-GD2 antibody ch14.18/CHO may improve outcome in patients (pts) with high risk relapsed/refractory neuroblastoma (NB). Methods: 97 pts received 6x106 IU/m2 sc IL2 (d1-5; 8-12), LTI of 100 mg/m2 ch14.18/CHO (d8-17) and 160 mg/m2 oral 13-cis-RA (d19-32) in an ongoing SIOPEN Phase II study (APN311-202) (NCT01701479) (44 pts) and a closed single center program (53 pts) (APN311-303). Response assessments followed INRG criteria. Fcγ-receptor polymorphisms FCGR2A (H131R), -3A (V158F) and -3B (NA1/NA2) were determined. Results: A decreasing degree of morphine usage and low pain scores were observed. Clinical overall responses were 30% (APN311-303) and 31% (APN311-202). The survival update of the APN311-303 cohort revealed a 1-y & 4-y OS of 94.2±3.2% & 60.9±9.0% (median FU 2.9y [0.7-5.2y]) and a 1-y & 4-y PFS of 54.4±6.9% & 32.3% ±6.9% (median FU 2.8y [0.7 - 4.9y]). Median TTP was 571d (95% CI: 232.7d). The comparator is the reported historical gold standard with 1-y & 4-y PFS of 19±2% & 8±3% and OS of 56±3% & 14±4% and a median TTP of 63 d (95% CI: 56.8d). NB pts with high affinity FCGR alleles and an increase in ADCC (cut off 15%) are associated with longer PFS and OS rates (p < 0.03; p < 0.005), which supports NK-cell mediated ADCC as the mechanism of action. Parameters of immune modulation (CDC, and WBT) and pharmacokinetics (PK) of ch14.18/CHO were comparable between APN311-202 and -303 cohorts. PK of ch14.18/CHO was analyzed in cycle 1: Cmax= 12.2±0.4μg/ml, t½= 8.4±1.1 d, AUC = 145.3± 5.8 μg*d/ml, Vd = 9.3±0.5L/m2. A pro-inflammatory cytokine response (IL-2, IL-6, IL-8, IFNγ) translated into the expansion of effector NK- (3x) and T-cells (2x). We observed HACA in 17/97 pts (17.5%) of which only 9/97 (9.3%) were neutralizing with respect to the inhibition of CDC and WBT activity. In HACA negative patients, levels of ch14.18/CHO and functional parameters (CDC, WBT) analyzed before subsequent treatment cycles indicate persistent anti-NB activity for the entire treatment period. Conclusion: LTI of ch14.18/CHO is active and effective in high-risk relapsed/refractory NB. Clinical trial information: NCT01701479.
Inverse design of phononic crystals by topology optimization (2005)

Abstract Band gaps, i.e frequency ranges for which waves cannot propagate, can be found in most elastic structures if the material or structure has a specific periodic modulation of material properties. In this paper, we maximize phononic band gaps for infinite periodic beams modelled by Timoshenko beam theory, for infinite periodic, thick and moderately thick plates, and for finite thick plates. Parallels are drawn between the different optimized crystals and structures and several new designs obtained using the topology optimization method.
CMOS photonics for direct microprocessor I/O (2016)

Photonics implemented in unmodified microelectronics CMOS has the potential to resolve the microprocessor to memory interconnect bottleneck that restricts the performance of modern computers. Here, we review the development of a dual-core microprocessor with monolithically embedded, energy-efficient photonics that provides direct connection to memory.
In vitro induction of naive cytotoxic T lymphocytes with complexes of peptide and recombinant MHC class I molecules coated onto beads: role of TCR/ligand density (1998)

We previously reported that complexes of peptide with soluble single-chain recombinant MHC (SC-MHC) class I molecules are able to induce cytotoxic T lymphocytes (CTL) in vitro in a murine system with an efficiency comparable to that observed with peptide-pulsed dendritic cells as antigen-presenting cells. In this report, we have assessed the capacity of preformed peptide/SC-Kd complexes in monomeric or dimeric form as well as of peptide/SC-Kd-loaded beads to generate in vitro specific CTL responses from naive DBA/2 spleen cells. Peptide/SC-Kd-coated beads were consistently more efficient. We evaluated the role of costimulatory molecules, using monoclonal antibodies anti-CD80 or anti-CD86. In addition, the capacity of peptide/SC-Kd-coated beads to generate a CTL response from purified naive CD8+ T cells was ascertained. Taken together, the results indicate that, under our conditions, CTL priming does not require the participation of co-stimulatory molecules and is the consequence of a direct interaction between the cognate TCR on peptide-specific CTL precursors and the peptide/SC-Kd-loaded beads. Titration of the amount of preformed complexes of SC-Kd and peptide 170-179 of HLA-CW3 that need to be coated onto the beads to prime CTL precursors shows an activation threshold which can be calculated to be between 25000 and 50000 complexes. In effect, in cultures stimulated with specific peptide CW3/SC-Kd complexes representing less than 50% occupancy of the total (10(5)) complexes on the beads, no peptide-specific cytolytic activity was observed. These results suggest that the efficiency of the primary CTL induction depends on the density of specific peptide/SC-Kd complexes present on the beads.
Dual-mode digital holographic and fluorescence microscopy for the study of morphological changes in cells under simulated microgravity (2010)

A dual mode microscope is developed to study morphological evolution of mouse myoblast cells under simulated microgravity in real time. Microscope operates in Digital Holographic Microscopy (DHM) and widefield epifluorescence microscopy modes in a time sequential basis. DHM provides information on real time cellular morphology. EGFP transfected actin filaments in mouse myoblast cells function as the reporter for the fluorescence microscopy mode. Experimental setup is fixed in the RPM to observe microgravity induced dynamic changes in live cells. Initial results revealed two different modifications. Disorganized structures become visible in the formed lamellipodias, and proteins accumulate in the perinuclear region.
Adversarial Open Domain Adaptation for Sketch-to-Photo Synthesis (2022)

In this paper, we explore open-domain sketch-to-photo translation, which aims to synthesize a realistic photo from a freehand sketch with its class label, even if the sketches of that class are missing in the training data. It is challenging due to the lack of training supervision and the large geometric distortion between the freehand sketch and photo domains. To synthesize the absent freehand sketches from photos, we propose a framework that jointly learns sketch-to-photo and photo-to-sketch generation. However, the generator trained from fake sketches might lead to unsatisfying results when dealing with sketches of missing classes, due to the domain gap between synthesized sketches and real ones. To alleviate this issue, we further propose a simple yet effective open-domain sampling and optimization strategy to "fool" the generator into treating fake sketches as real ones. Our method takes advantage of the learned sketch-to-photo and photo-to-sketch mapping of in-domain data and generalizes it to the open-domain classes. We validate our method on the Scribble and SketchyCOCO datasets. Compared with the recent competing methods, our approach shows impressive results in synthesizing realistic color, texture, and maintaining the geometric composition for various categories of open-domain sketches.
Extrabiliary applications of fully covered antimigration biliary metal stents (2020)

Although off label, extrabiliary use of these stents can successfully address scenarios of complex luminal pathology. To compensate for the small stent caliber, two stents may be placed side by side in a double-barrel configuration. Strict diet modifications are necessary when applying this therapeutic paradigm.
The influence of monomer concentration and diluents on the polymerization of isobutene (1961)

Abstract The relation existing between monomer concentration and degree of polymerization of polyisobutenes obtained in various diluents with AlCl 3 catalyst has been investigated at −78°C. Methyl chloride, ethyl chloride, methylene chloride, vinyl chloride, and n ‐pentane were used as diluents. It was demonstrated that the DP increases with decreasing monomer concentration irrespective of the investigated polymerization medium. A hypothesis which could explain the experimental facts is presented. The influence of dielectric constant on the molecular weight of polyisobutene has been studied in methyl chloride—carbon disulfide mixtures. The seeming contradiction existing between experimental findings and expectation based on older theories has been resolved by the introduction of “effective D.C.” theory. The “lifetime” of carbonium ions and the “temperature build‐up” in the fast low‐temperature polymerization has been estimated.
Investigating Limitations of a Two-Zone NOx Model Applied to DI Diesel Combustion Using 3-D Modeling (2016)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;A two-zone NOx model intended for 1-D engine simulations was developed and used to model NOx emissions from a 2.5 L single-cylinder engine. The intent of the present work is to understand key aspects of a simple NOx model that are needed for predictive accuracy, including NOx formation and destruction phenomena in a DI Diesel combustion system. The presented two-zone model is fundamentally based on the heat release rate and thermodynamic incylinder data, and uses the Extended Zeldovich mechanism to model NO. Results show that the model responded very well to changes in speed, load, injection timing, and EGR level. It matched measured tail pipe NOx levels within 20%, using a single tuning setup. When the model was applied to varied injection rate shapes, it showed correct sensitivity to speed, load, injection timing, and EGR level, but the absolute level was well outside the target accuracy. The same limitation was seen when applying the Plee NOx model. Detailed CFD simulations showed that NO destruction is significant, occurs throughout the mixing controlled heat release, and can be up to 35% of the total formed NO. NO formation was confirmed to primarily occur in fuel lean regions around equivalence ratios of 0.95, and NO destruction was found to primarily occur in fuel rich regions stemming from the third Extended Zeldovich reaction. Fuel injection rate shaping changed the balance of NO formation and destruction in engine applications, but not in free-jet scenarios. Future paths focus on building the necessary fidelity into a computationally efficient NOx model, leveraging understanding from more detailed approaches.&lt;/div&gt;&lt;/div&gt;
Parsing the Free Energy of Anthracycline Antibiotic Binding to DNA (1996)

The DNA binding free energy of eight anthracycline antibiotics was determined as a function of NaCl concentration. Compounds were chosen for study that differed from the parent compounds, doxorubicin or daunorubicin, at a single chemical substituent. Determination of the salt concentration dependence of the binding constant allowed us to dissect the DNA binding free energy of each compound into its component nonelectrostatic and polyelectrolyte contributions. Comparison of the nonelectrostatic free energy contribution allowed us to evaluate the net energetic contribution of specific functional groups to DNA binding. These quantitative data revealed a surprisingly large and favorable energetic contribution (2 kcal (mol-1)) of the groove-binding daunosamine moiety and a substantial energetic penalty for alteration of its stereochemistry. The energetic cost of removal of hydroxyl groups at the C-9 and C-14 positions (which structural studies indicate may participate in hydrogen-bonding interactions with the DNA) was approximately 1 kcal mol(-1). Replacement of the 3'-amino group with a hydroxyl group led to a loss of 0.7 kcal mol(-1) in binding free energy, above and beyond the energetic penalty resulting from the removal of its positive charge from the antibiotic. The results and analysis presented here provide a rigorous and detailed description of structure-DNA affinity relationships among anthracycline antibiotics. The results are of general interest in understanding how total ligand binding free energies are partitioned among substituents and will be useful in the formulation of rules for the rational design of novel DNA binding agents.
A herbicide structure–activity analysis of the antimalarial lead compound MMV007978 against Arabidopsis thaliana (2018)

We demonstrate that the antimalarial compound MMV007978 is also herbicidal and that exploiting lead compounds that are often understudied could lead to the identification of interesting herbicidal scaffolds. Further structural investigation of MMV007978 could provide improved herbicidal chemistries with a potential new mode of action. © 2018 Society of Chemical Industry.
Oncogenic human papillomavirus type 16 is associated with squamous cell cancer of the male urethra. (1992)

Human papillomaviruses (HPV), especially genotypes 16 and 18, are probable effectors of human urogenital malignancies. Although the male urethra is a proposed reservoir of HPV transmission, the association between HPV and squamous cell carcinoma (SCC) of the male urethra has not been studied. The highly sensitive technique of polymerase chain reaction with type-specific HPV 16 and 18 primers and general primers, including nine other genotypes was used to survey a series of SCC of the male urethra for the prevalence of an association with HPV. Archival surgical specimens from 14 patients were analyzed, and primary, recurrent, and metastatic lesions from 4 (29%) patients contained HPV 16 DNA. No other HPV genotype (6b, 11, 13, 18, 30, 31, 33, 35, 45, 51) was detected. Complete concordance for the presence of HPV in primary and recurrent or metastatic disease was demonstrated. These findings strongly suggest that HPV type 16 is associated with a substantial subset of SCCs of the male urethra. Analysis of clinical data revealed that HPV-positive tumors had a significant predilection for location in the pendulous urethra versus the bulbar urethra. Survival data analysis showed that the presence of HPV more closely correlated with prolonged survival than did tumor location. The presence or absence of HPV 16 DNA defines two subsets of SCC of the male urethra which differ in the site of occurrence and, possibly, progression.
Effects of Total Ionizing Dose on PEDOT/PSS Organic Memory Devices (Poster). (2021)

Abstract not provided.
Third-order optical nonlinearities in semiconductors: The two-band model (1994)

We calculate the coherent electronic contributions to the third-order optical response ${\mathrm{\ensuremath{\chi}}}^{(3)}$(-\ensuremath{\omega};\ensuremath{\omega},\ensuremath{\Omega},-\ensuremath{\Omega}) of bulk semiconductors in the independent-particle approximation using a simple two-band model. The formalism used to derive this response coefficient naturally accounts for all relevant contributions and, in contrast to existing results in the literature, leads to physically realistic, nondivergent expressions in the limits \ensuremath{\omega},\ensuremath{\Omega}\ensuremath{\rightarrow}0. Such well behaved infrared limits imply that the imaginary part of our ${\mathrm{\ensuremath{\chi}}}^{(3)}$ correctly describes the dispersion of nondegenerate absorption; indeed for \ensuremath{\Omega}=0 our results are consistent with predictions from Franz-Keldysh theory. Complementing these results, we can now also unambiguously extract from the real part of ${\mathrm{\ensuremath{\chi}}}^{(3)}$ the below band gap, two-band model predictions for the nonlinear refractive index, the dc Kerr effect, and the virtual photoconductivity; all of these predict a finite, real ${\mathrm{\ensuremath{\chi}}}^{(3)}$(0;0,0,0) as physically expected for clean, cold semiconductors. Finally, our specific results help expose more general consequences of the gauge choice when employing common approximate band-structure models.
PS 13-10 INDUCTION OF ANGIOGENESIS BY A TYPE III PHOSPHODIESTERASE INHIBITOR THROUGH ACTIVATION OF PPAR GAMMA AND cAMP PATHWAYS (2016)

Objective: Peripheral arterial disease (PAD) is highly prevalent in the elderly as well as in the subjects with cardiovascular risk factors such as diabetes. Approximately 2–4% of those affected with PAD commonly complain of intermittent claudication (IC). Cilostazol, a type III phosphodiesterase inhibitor, is the only FDA-approved drug for the treatment of IC. Cilostazol has been shown to be beneficial for the improvement of pain-free walking distance in patients with IC in a series of randomized clinical trials. However, the underlying mechanism how cilostazol improved IC symptoms is still unclear. Design and Method: In this study, the effect of cilostazol on ischemic leg was investigated in mouse ischemic hind limb model. Results: Administration of cilostazol significantly increased the expression of hepatocyte growth factor (HGF), vascular endothelial growth factor, angiopoietin-1, and peroxisome proliferator-activated receptor (PPAR)-γ in vasculature. The capillary density in ischemic leg was also significantly increased in cilostazol treatment group as compared to control and aspirin treatment group. However, an increase in capillary density and the expression of growth factors was almost completely abolished by co-administration of HGF-neutralizing antibody, suggesting that cilostazol enhanced angiogenesis mainly through HGF. In vitro experiment revealed that cilostazol treatment increased HGF production in vascular smooth muscle cells via two major pathways, PPAR-γ and cAMP pathways. Conclusions: Our data suggest that the favorable effects of cilostazol on ischemic leg might be through the angiogenesis through the induction of HGF via PPAR-γ and cAMP pathways.
Long-term room temperature stability of TlBr gamma detectors (2011)

TlBr is a material of interest for use in room temperature gamma ray detector applications due to is wide bandgap 2.7 eV and high average atomic number (Tl 81, Br 35). Researchers have achieved energy resolutions of 1.3 % at 662 keV, demonstrating the potential of this material system. However, these detectors are known to polarize using conventional configurations, limiting their use. Continued improvement of room temperature, high-resolution gamma ray detectors based on TlBr requires further understanding of the degradation mechanisms. While high quality material is a critical starting point for excellent detector performance, we show that the room temperature stability of planar TlBr gamma spectrometers can be significantly enhanced by treatment with both hydrofluoric and hydrochloric acid. By incorporating F or Cl into the surface of TlBr, current instabilities are eliminated and the longer term current of the detectors remains unchanged. <sup>241</sup>Am spectra are also shown to be more stable for extended periods; detectors have been held at 2000 V/cm for 52 days with less than 10% degradation in peak centroid position. In addition, evidence for the long term degradation mechanism being related to the contact metal is presented.
Selective Deposition of Compositionally Graded Hybrid Adhesive Films (2015)

Hybrid organic–inorganic materials that are compositionally graded are excellent candidates for addressing the challenges related to the bonding of polymeric layers and inorganic substrates. Often, the synthesis of these hybrid materials involves the use of kinetically driven and dynamic solution systems where obtaining the desired hybrid molecular structures in the deposited film is not trivial. A coating process is used to selectively deposit a small fraction of the total species in solution with an optimized molecular weight, resulting in compositionally graded hybrid films that are organic‐rich toward the top and inorganic‐rich toward the bottom. This selective deposition technique provides a unique knob to fine tune the molecular structure of films deposited from dynamic solution systems, resulting in hybrid organic–inorganic films that exhibit an eightfold increase in adhesion of an epoxy/silicon interface.
Signal-to-noise ratio in a frequency multiplexing imager (1983)

The signal-to-noise ratio ( <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">S/N</tex> ) to be expected in a frequency multiplexing imager is calculated. It is shown that, for an ideal detector, the <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">S/N</tex> is comparable to the two-dimensional (2D) scanning imager. For low performance detectors, the frequency multiplexing imager is noticeably better, and in limiting cases, file <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">S/N</tex> approaches that of a BLIP system, independent of detector performance.