gebhart/patrepeval huggingface dataset:
Nano PGE1 Enhances Phosphorylation of ERK1/2 and Akt to Promote Recovery from Motor Dysfunction and Muscle Atrophy Induced by Sciatic Nerve Injury (2019)

The effect of prostaglandin E1 (PGE1) encapsulated in nanoparticles (Nano PGE1) on motor dysfunction and muscle atrophy induced by sciatic nerve injury (SNI) was investigated in rats, and was compared with PGE1 encapsulated in lipid microspheres (Lipo PGE1) or PGE1 clathrated in cyclodextrin (PGE1-CD). The hind limb muscle weight ratio decreased until 2 weeks after SNI. All 3 PGE1 formulations significantly improved SNI-induced motor dysfunction. Nano PGE1 significantly promoted recovery from muscle atrophy at 2 and 3 weeks after SNI. Lipo PGE1 was also effective, but multiple doses were required. Compared with the SNI control group, the Nano PGE1 group showed upregulation of vascular endothelial growth factor (VEGF) and agrin expression in the injured sciatic nerve and atrophic muscles. Nano PGE1 accumulated prominently at the site of nerve injury and persisted for longer than Lipo PGE1 or PGE1-CD. Expression of all EP receptors was detected in the normal sciatic nerve, and EP2 expression increased after SNI. Finally, Nano PGE1 promoted ERK1/2 and Akt phosphorylation. These findings suggest that PGE1 released from nanoparticles accumulates at sites of nerve injury and increases VEGF production by augmenting ERK1/2 phosphorylation via EP receptor signaling, thus promoting tissue repair and regeneration.
((DABCO)·ZnGe(HPO4)3:  The First Zinco−Germanophosphate with a Unique Asymmetric Cage (2000)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXT((DABCO)·ZnGe(HPO4)3: The First Zinco−Germanophosphate with a Unique Asymmetric CageJianmin Li, Yanxiong Ke, Yugen Zhang, Gaofei He, Zheng Jiang, Masayoshi Nishiura, and Tsuneo ImamotoView Author Information Department of Chemical Physics and Department of Chemistry University of Science and Technology of China Hefei, Anhui, 230026, People's Republic of China Department of Chemistry, Faculty of Science Chiba University, Yayoi-cho, Inage-ku Chiba 263-8522, Japan Cite this: J. Am. Chem. Soc. 2000, 122, 25, 6110–6111Publication Date (Web):June 8, 2000Publication History Received10 January 2000Published online8 June 2000Published inissue 1 June 2000https://pubs.acs.org/doi/10.1021/ja000107mhttps://doi.org/10.1021/ja000107mrapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views322Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information SUBJECTS:Chemical structure,Crystal structure,Materials,Molecules,Phosphates Get e-Alerts
Growth of IrO2 Films and Nanorods by Means of CVD: An Example of Compositional and Morphological Control of Nanostructures (2003)

Conductive iridium oxide films or one‐dimensional nanorods are deposited using (MeCp)Ir(COD). A systematic investigation is carried out, showing a close correlation of morphology with deposition pressure and oxygen partial pressure. Of particular interest, are the vertically aligned IrO 2 nanorods (see Figure) deposited at 350 °C in 30 torr of oxygen. The surface morphology and structural composition of the materials are confirmed.
Polyacetylene Derivatives with Chain-Sided Phenoxy and Galvinoxyl Radicals (1993)

Abstract Polyacetylene derivatives bearing chain-sided, π-conjugated and bult-in phenoxy radicals were synthesized. They were soluble in common solvents and gave a transparent thin-film. ESR indicated partial deloalization of the unpaired electron generated in the chain-sided group into the main chain. But any ferromagnetic interaction between the spins could not be observed.
Spatio-temporal expression and distribution of collagen VI during zebrafish development (2019)

Collagen VI (ColVI) is an extracellular matrix (ECM) protein involved in a range of physiological and pathological conditions. Zebrafish (Danio rerio) is a powerful model organism for studying vertebrate development and for in vivo analysis of tissue patterning. Here, we performed a thorough characterization of ColVI gene and protein expression in zebrafish during development and adult life. Bioinformatics analyses confirmed that zebrafish genome contains single genes encoding for α1(VI), α2(VI) and α3(VI) ColVI chains and duplicated genes encoding for α4(VI) chains. At 1 day post-fertilization (dpf) ColVI transcripts are expressed in myotomes, pectoral fin buds and developing epidermis, while from 2 dpf abundant transcript levels are present in myosepta, pectoral fins, axial vasculature, gut and craniofacial cartilage elements. Using newly generated polyclonal antibodies against zebrafish α1(VI) protein, we found that ColVI deposition in adult fish delineates distinct domains in the ECM of several organs, including cartilage, eye, skin, spleen and skeletal muscle. Altogether, these data provide the first detailed characterization of ColVI expression and ECM deposition in zebrafish, thus paving the way for further functional studies in this species.
Ethylene–Butadiene Copolymerization by Neodymocene Complexes: A Ligand Structure/Activity/Polymer Microstructure Relationship Based on DFT Calculations (2015)

Ethylene/butadiene copolymerization can be performed by neodymocene catalysts in the presence of an alkylating/chain transfer agent. A variety of polymerization activities and copolymer microstructures can be obtained depending on the neodymocene ligands. For a set of four catalysts, namely (C5Me5)2NdR, [Me2Si(3-Me3SiC5H3)2]NdR, [Me2Si(C5H4)(C13H8)]NdR and [Me2Si(C13H8)2]NdR, we report a DFT mechanistic study of this copolymerization reaction performed in the presence of dialkylmagnesium. Based on the modeling strategy developed for the ethylene homopolymerization catalyzed by (C5Me5)2NdR in the presence of MgR2, our model is able to account for the following: (i) the formation of Nd/Mg heterobimetallic complexes as intermediates, (ii) the overall differential activity of the catalysts, (iii) the copolymerization reactivity indexes, and (iv) the specific microstructure of the resulting copolymers, including branching and cyclization. The analysis of the reaction mechanisms and the energy profiles thus relates ligand structure, catalyst activity, and polymer microstructure and sets the basis for further catalyst developments.
UPPS Dimensions of Impulsivity (2013)

Although cognitive distortions are widely acknowledged in the explanation of impulsivity-related psychopathologies (and more recently in the explanation of specific impulsive behaviors), no study has systematically verified whether they can also explain the cognitive processes underlying these impulsivity traits of personality: urgency, lack of premeditation, lack of perseverance, and sensation seeking (UPPS). Moreover, childhood maltreatment has been frequently associated with both cognitive distortions and impulsive behaviors but never with UPPS traits. A study was conducted on undergraduate students to examine the influence of cognitive distortions and childhood maltreatment on four dimensions of impulsivity from the UPPS Impulsive Behavior Scale. Regression analyses revealed that Premature Processing, a term applied to a group of seven cognitive distortions such as emotional reasoning and confusing needs and wants, as well as childhood maltreatment, was able to predict significantly and independently the Negative Urgency dimension of impulsivity, above and beyond gender and the three other subscales of the UPPS Impulsive Behavior Scale. Coherent with Beck’s cognitive model, these results suggest that the Negative Urgency trait is associated with cognitive distortions that can undermine thought processes in a variety of ways, increasing the likelihood of acting rashly. However, more studies are needed to develop instruments and identify specific forms of cognitive distortions associated with impulsivity traits.
Development of Synthesis and Large Scale Production Technology for Ultrahigh Energy and Density Fluoro-Organic Compounds (2005)

Abstract : The research addressed the laboratory production and testing and commercialization aspects of producing high-density fluorine-rich compounds that were significantly more reactive and energetic than conventional explosives to neutralize and destroy chemical and biological agents. The primary synthetic goals followed both poly-SF5-butane and SF5-containing polymers formed by the free radical chain (FRC) process. For the first time, polymers with a significant degree of incorporation of an SF5-bearing monomer were prepared and characterized. Synthesis of three different SF5-containing polymers was investigated as a prerequisite for polymerization. These monomers were: pentafluorosulfanylethene, 1,1-difluro-2-pentafluorosulfanylethene, and 1,1, 2-trifluoro-2-pentafluorosulfanylethene. Combustion testing was performed in an externally heated reactor containing air and other oxidative gaseous mixtures under pressure.
A Novel Endonuclease Inhibitor Exhibits Broad-Spectrum Anti-Influenza Virus Activity In Vitro (2016)

Antiviral drugs are important in preventing and controlling influenza, particularly when vaccines are ineffective or unavailable. A single class of antiviral drugs, the neuraminidase inhibitors (NAIs), is recommended for treating influenza. The limited therapeutic options and the potential risk of antiviral resistance are driving the search for additional small-molecule inhibitors that act on influenza virus proteins. The acid polymerase (PA) of influenza viruses is a promising target for new antivirals because of its essential role in initiating virus transcription. Here, we characterized a novel compound, RO-7, identified as a putative PA endonuclease inhibitor. RO-7 was effective when added before the cessation of genome replication, reduced polymerase activity in cell-free systems, and decreased relative amounts of viral mRNA and genomic RNA during influenza virus infection. RO-7 specifically inhibited the ability of the PA endonuclease domain to cleave a nucleic acid substrate. RO-7 also inhibited influenza A viruses (seasonal and 2009 pandemic H1N1 and seasonal H3N2) and B viruses (Yamagata and Victoria lineages), zoonotic viruses (H5N1, H7N9, and H9N2), and NAI-resistant variants in plaque reduction, yield reduction, and cell viability assays in Madin-Darby canine kidney (MDCK) cells with nanomolar to submicromolar 50% effective concentrations (EC50s), low toxicity, and favorable selective indices. RO-7 also inhibited influenza virus replication in primary normal human bronchial epithelial cells. Overall, RO-7 exhibits broad-spectrum activity against influenza A and B viruses in multiple in vitro assays, supporting its further characterization and development as a potential antiviral agent for treating influenza.
Failure Mechanisms in PMMA/ATH Acrylic Casting Dispersion (2006)

Acrylic casting dispersion is used to fabricate particulate composites such as poly-methyl methacrylate (PMMA) filled with a fine dispersion alumina trihydrate (). This composite is subjected to severe temperature variations during in-service conditions, giving rise to high thermal stresses which lead to failure by cracking. The influence of the interfacial bond strength between a particle and the matrix on the failure mechanism of acrylic casting dispersion has been investigated using in situ observations during tensile and compressive loadings. Experiments show that the failure in pure tension occurs differently than in flexure loading where the failure process is believed to be more complex. During tensile loading, it is observed that macroscopic fracture is initiated in the clusters of the reinforcing particles because of the strong interfacial bonding strength between the filler particles and matrix. For weak interfacial bond strength, the macroscopic fracture is initiated by separation of filler agglomerates from the matrix.
Hydrophobically Modified Polyelectrolytes in Dilute Salt-Free Solutions (2000)

The universal diagram of states of hydrophobically modified polyelectrolytes in dilute salt-free solutions is calculated in the framework of the scaling approach. The equilibrium conformations of these polymers were classified using two parametersgeometric and energetic ratios of hydrophobic and polyelectrolyte blocks in unassociated states (the ratio of block sizes and the ratio of block energies). The hydrophobically modified polyelectrolytes self-organize either into necklaces of hairy, crew-cut, or braided micelles or into wormlike cylindrical micelles depending on the values of these two parameters. The universal diagram of states is modified by the counterion condensation.
Immunological Studies on the Blood Coagulation Factor X and Its Warfarin-induced Precursor (1974)

Summary Monospecific antisera against the human coagulation factor X have been raised in rabbits by injections of purified antigen. Such antiserum was used to study the cross-reacting material without factor X activity which is present in the blood of warfarin-treated patients and animals as well as to study the changes in factor X during coagulation. One patient with congenital factor X deficiency was also studied. A complete identity was found between factor X in Macaca mulatta and human blood. During warfarin treatment antigenically cross-reacting material appeared in plasma. This was not adsorbed on BaSO4, and inhibited the coagulation activity of normal factor X. Both this material, normal factor X and the cross-reacting material in plasma from a patient congenitally deficient in factor X gave rise to split products during coagulation by the intrinsic pathway, i. e. all of them served as substrates for the intrinsic activator of factor X.
Efficient sorting, duplicate removal, grouping, and aggregation (2020)

Database query processing requires algorithms for duplicate removal, grouping, and aggregation. Three algorithms exist: in-stream aggregation is most efficient by far but requires sorted input; sort-based aggregation relies on external merge sort; and hash aggregation relies on an in-memory hash table plus hash partitioning to temporary storage. Cost-based query optimization chooses which algorithm to use based on several factors including the sort order of the input, input and output sizes, and the need for sorted output. For example, hash-based aggregation is ideal for output smaller than the available memory (e.g., TPC-H Query 1), whereas sorting the entire input and aggregating after sorting are preferable when both aggregation input and output are large and the output needs to be sorted for a subsequent operation such as a merge join. Unfortunately, the size information required for a sound choice is often inaccurate or unavailable during query optimization, leading to sub-optimal algorithm choices. In response, this paper introduces a new algorithm for sort-based duplicate removal, grouping, and aggregation. The new algorithm always performs at least as well as both traditional hash-based and traditional sort-based algorithms. It can serve as a system's only aggregation algorithm for unsorted inputs, thus preventing erroneous algorithm choices. Furthermore, the new algorithm produces sorted output that can speed up subsequent operations. Google's F1 Query uses the new algorithm in production workloads that aggregate petabytes of data every day.
The magic and mystery of miR-21 (2010)

MicroRNAs (miRNAs) are potent regulators of mRNA stability and thereby protein expression. As such, miRNAs have become of interest as possible therapeutics and/or therapeutic targets. In this context, small complementary miRNA sequences known as antagomirs could be used to inhibit miRNA activity, while miRNA mimics could confer gain-of-function activity. However, a note of caution is sounded by Patrick et al. in this issue of the JCI, as they show that although recent reports have suggested that an miR-21 antagomir might be therapeutically useful in preventing heart failure in mice, genetic deletion of miR-21 does not confer a similar phenotype, suggesting possible confounding factors that are only now beginning to be revealed in the techniques used to study miRNA biology.
Enhancing Genetic Gain through Genomic Selection: From Livestock to Plants (2019)

Although long-term genetic gain has been achieved through increasing use of modern breeding methods and technologies, the rate of genetic gain needs to be accelerated to meet humanity's demand for agricultural products. In this regard, genomic selection (GS) has been considered most promising for genetic improvement of the complex traits controlled by many genes each with minor effects. Livestock scientists pioneered GS application largely due to livestock's significantly higher individual values and the greater reduction in generation interval that can be achieved in GS. Large-scale application of GS in plants can be achieved by refining field management to improve heritability estimation and prediction accuracy and developing optimum GS models with the consideration of genotype-by-environment interaction and non-additive effects, along with significant cost reduction. Moreover, it would be more effective to integrate GS with other breeding tools and platforms for accelerating the breeding process and thereby further enhancing genetic gain. In addition, establishing an open-source breeding network and developing transdisciplinary approaches would be essential in enhancing breeding efficiency for small- and medium-sized enterprises and agricultural research systems in developing countries. New strategies centered on GS for enhancing genetic gain need to be developed.
Inferred Immune-Cell Activity Is an Independent Predictor of HER2-Negative Breast Cancer Prognosis and Response to Paclitaxel-Based Therapy in the GeparSepto Trial (2023)

Overall, TIL level better predicted pCR, but iICA cluster better predicted survival. Differences in associations between TILs, cluster, pCR, and survival were observed for HR-positive tumors versus HR-negative tumors, suggesting expanded study of the implication of these findings is warranted.
Multiple clock and voltage domains for chip multi processors (2009)

Power and thermal are major constraints for delivering compute performance in high-end CPU and are expected to be so in the future. CMP is becoming important by delivering more compute performance within the power constraints. Dynamic Voltage and Frequency Scaling (DVFS) has been studied in past work as a mean to increase save power and improving the overall processor's performance while meeting the total power and/or thermal constraints. For such systems, power delivery limitations are becoming a significant practical design consideration, unfortunately this aspect of the design was almost ignored by many research works. This paper explores the various possible topologies to build a high end multi-core CPU and the available policies that maximize performance within the set of physical limitations. It evaluates single and multiple voltage and frequency domains and introduces a new clustered topology, grouping several cores together. A hybrid model, using measurements of a real CPU, cycle accurate simulator and an analytical model is introduced. The results presented indicate that considering power delivery limitations diverts the conclusions when such limitations are ignored. This paper shows that a single power domain topology performs up to 30% better than multiple power domains on light-threaded workload. In the fully threaded application the results divert. Clustered topology performs well for any number of threads.
Continuous diffraction patterns from circular arrays of carbon nanotubes (2012)

We report the remarkable diffraction effects produced from circular patterned arrays of multiwalled carbon nanotubes (MWCNTs). Highly ordered circular arrays of multiwalled carbon nanotubes (with inter-nanotube spacings of 633 nm) display optical dispersion effects similar to compact discs. These arrays display remarkable diffraction patterns in the far field which are spatially continuous. High quality diffraction patterns were obtained experimentally which are in excellent agreement with the theoretical calculations. The achieved continuous diffraction patterns pave the way towards the utilization of engineered carbon nanotube arrays in applications like three dimensional holograms.
Kinect Deform: Enhanced 3D Reconstruction of Non-rigidly Deforming Objects (2014)

In this work we propose Kinect Deform, an algorithm which targets enhanced 3D reconstruction of scenes containing non-rigidly deforming objects. It provides an innovation to the existing class of algorithms which either target scenes with rigid objects only or allow for very limited non-rigid deformations or use precomputed templates to track them. Kinect Deform combines a fast non-rigid scene tracking algorithm based on octree data representation and hierarchical voxel associations with a recursive data filtering mechanism. We analyze its performance on both real and simulated data and show improved results in terms of smoothness and feature preserving 3D reconstructions with reduced noise.
Ten-year trends, predictors and outcomes of mechanical circulatory support in percutaneous coronary intervention for acute myocardial infarction with cardiogenic shock (2021)

MCS-assisted PCI identified a sicker AMI-CS cohort. There was a decrease in IABP and an increase in pLVAD/ECMO.
Caractérisation et modélisation d’une nouvelle technologie de synthétiseur d’impédances automatiques coaxial 3,5mm à fort TOS (2015)

National audience
Standardization Activities for Radio on Fiber Transmitter within IEC TC103/WG5 (2013)

This paper describes the outline of recent standardization activities for Radio on Fiber (RoF) transmitter by IEC TC103/WG5. RoF transmitter consists of optical fibers, electrical to optical (E/O) converter, and optical to electrical (O/E) converter. IEC TC103/WG5 is working on standardization on measurement method of E/O and O/E devices, and technical specification of RoF transmitter. This paper overviews those standardization activities which are being developed by TC103/WG5 as well as the National Committee of WG5.
Efficient Joint Gradient Based Attack Against SOR Defense for 3D Point Cloud Classification (2020)

Deep learning based classifiers on 3D point cloud data have been shown vulnerable to adversarial examples, while a defense strategy named Statistical Outlier Removal (SOR) is widely adopted to defend adversarial examples successfully, by discarding outlier points in the point cloud.