gebhart/patrepeval huggingface dataset:
Chemistry, Processing, and Microwave Dielectric Properties of Mn‐Substituted KTaO 3 Ceramics (2009)

Mn‐doped KTaO 3 samples were prepared by the solid‐state method. From the analysis of A‐and B‐site substitution characteristics, we determined the solid solubility limits for both doping mechanisms, the influence on unit cell parameters, the phase relations, and the sintering characteristics. The sintered samples were used for the analysis of microwave dielectric properties. From the temperature and frequency dependence of permittivity and dielectric loss as a function of Mn content in KTaO 3 the behavior of polar regions, induced by the doping, was estimated.
Image analysis of topical drug uptake in tissue after ablative fractional laser treatment (2022)

Ablative fractional laser (AFL) treatment prior to application of a topical drug enhances drug uptake and the resultant coagulation zone (CZ) surrounding each fractional photothermal injury may provide a reservoir for sustained drug release. In this work, we evaluate how morphological changes in the skin after AFL affect the uptake of an intrinsically fluorescent topical antibiotic. Brightfield images of NBTC stained histopathological slides were evaluated using a deep learning approach for semantic segmentation of fractional laser patterns for automatic assessment of laser hole diameter and CZ morphology. Last, collagen denaturation and drug uptake were quantified via polarization and fluorescence microscopy, respectively.
Global loss of Tfr2 with concomitant induced iron deficiency greatly ameliorates the phenotype of a murine thalassemia intermedia model (2020)

β-thalassemias result from mutations in β-globin, causing ineffective erythropoiesis and secondary iron overload due to inappropriately low levels of the iron regulatory hormone hepcidin. Mutations in transferrin receptor 2 (TFR2) lead to hereditary hemochromatosis (HH) as a result of inappropriately increased iron uptake from the diet, also due to improperly regulated hepcidin. TFR2 is also thought to be required for efficient erythropoiesis through its interaction with the erythropoietin receptor in erythroid progenitors. Transmembrane serine protease 6 (TMPRSS6), a membrane serine protease expressed selectively in the liver, participates in regulating hepcidin production in response to iron stores by cleaving hemojuvelin (HJV). We have previously demonstrated that inhibiting TMPRSS6 expression with a hepatocyte-specific siRNA formulation, induces hepcidin, mitigates anemia, and reduces iron overload in murine models of β-thalassemia intermedia and HH. Here, we demonstrate that Tmprss6 siRNA treatment of double mutant Tfr2<sup>Y245X/Y245X</sup> HH Hbb<sup>th3/+</sup> thalassemic mice induces hepcidin and diminishes tissue and serum iron levels. Importantly, treated double mutant animals produce more mature red blood cells and have a nearly 50% increase in hemoglobin compared to untreated β-thalassemic mice. Furthermore, we also show that treatment of Tfr2<sup>Y245X/Y245X</sup> HH mice leads to increased hepcidin expression and reduced total body iron burden. These data indicate that siRNA suppression of Tmprss6, in conjunction with the targeting of TFR2, may be superior to inhibiting Tmprss6 alone in the treatment of the anemia and secondary iron loading in β-thalassemia intermedia and may be useful as a method of suppressing the primary iron overload in TFR2-related (type 3) hereditary hemochromatosis.
Exploring the Potential of Benzene-1,3,5-tricarboxamide Supramolecular Polymers as Biomaterials (2020)

The fast dynamics occurring in natural processes increases the difficulty of creating biomaterials capable of mimicking Nature. Within synthetic biomaterials, water-soluble supramolecular polymers show great potential in mimicking the dynamic behavior of these natural processes. In particular, benzene-1,3,5-tricaboxamide (BTA)-based supramolecular polymers have shown to be highly dynamic through the exchange of monomers within and between fibers, but their suitability as biomaterials has not been yet explored. Herein we systematically study the interactions of BTA supramolecular polymers bearing either tetraethylene glycol or mannose units at the periphery with different biological entities. When BTA fibers were incubated with bovine serum albumin (BSA), the protein conformation was only affected by the fibers containing tetraethylene glycol at the periphery (BTA-OEG<sub>4</sub>). Coarse-grained molecular simulations showed that BSA interacted with BTA-OEG<sub>4</sub> fibers rather than with BTA-OEG<sub>4</sub> monomers that are present in solution or that may exchange out of the fibers. Microscopy studies revealed that, in the presence of BSA, BTA-OEG<sub>4</sub> retained their fiber conformation although their length was slightly shortened. When further incubated with fetal bovine serum (FBS), both long and short fibers were visualized in solution. Nevertheless, in the hydrogel state, the rheological properties were remarkably preserved. Further studies on the cellular compatibility of all the BTA assemblies and mixtures thereof were performed in four different cell lines. A low cytotoxic effect at most concentrations was observed, confirming the suitability of utilizing functional BTA supramolecular polymers as dynamic biomaterials.
Nonlinear interactions in slow-wave structures (2002)

Nonlinear interactions in coupled resonator slow-wave structures are investigated. Kerr-based phase modulation and wavelength conversion by four-wave-mixing result strongly enhanced thanks to both the increase of the intra-cavity mean power and the interaction time between propagating fields.
Comparison between direct current and radiofrequency glow discharge mass spectrometry for the analysis of oxide-based samples (1995)

Glow discharge mass spectrometry (GDMS) using either a direct current (dc) or a radiofrequency (rf) discharge has been evaluated. For conducting samples, comparable results are obtained, as indicated by the uniformity in relative sensitivity factors (RSFs). For the analysis of rare earth oxide materials, the RSFs for dc GDMS are far less affected by changes in discharge pressure and sample to exit-orifice distance than those obtained for rf GDMS. Despite the higher variability of RSFs for rf GDMS, very stable and reproducible plasma conditions are obtained when working at a fixed pressure and distance. The latter is indicated by the internal (within-sample) and external (sample-to-sample) reproducibility of less than 5 and 15%, respectively.
Development of Synthetic Ketonic Resin (2014)

In the present work, the self-polymerization reaction of cyclohexanone was studied to develop a synthetic resin. Synthetic resins are extensively used in paint industry to improve the adhesiveness of paints. Polymerization reactions were carried out in a high-pressure reactor. The results suggest that the self-polymerization of cyclohexanone mainly depends on alkali concentration, reaction temperature, and reaction time. As the ketone-to-alkali ratio decreases, the degree of polymerization increases, which leads to an increase in the hydroxyl value and softening point and a remarkable decrease in solubility. A good-quality solid resin could be obtained with a ketone-to-alkali ratio less than 5 in the temperature range between 130°C and 160°C and within the time duration of 12–22 h. These data may be useful to develop the desired quality of resin in the field of paint application.
<title>Adaptive critic design for computer intrusion detection system</title> (2001)

This paper summarizes ongoing research. A neural network is used to detect a computer system intrusion basing on data from the system audit trail generated by Solaris Basic Security Module. The data have been provided by Lincoln Labs, MIT. The system alerts the human operator, when it encounters suspicious activity logged in the audit trail. To reduce the false alarm rate and accommodate the temporal indefiniteness of moment of attack a reinforcement learning approach is chosen to train the network.
Kurzzeichen der Kunststoff-Technik (2022)

No AccessSaechtling Kunststoff-HandbuchOct 2022Kurzzeichen der Kunststoff-TechnikErwin Baur, Dietmar Drummer, Tim A. Osswald, Natalie RudolphErwin Baur, Dietmar Drummer, Tim A. Osswald, Natalie Rudolphhttps://doi.org/10.3139/9783446473614.001SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2022Pages: 1-12Print ISBN: 978-3-446-46514-5eISBN: 978-3-446-47361-4 Copyright & Permissions© 2022 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
Paleovirology of human endogenous retroviruses (2009)

Retroviral infection usually occurs within somatic cells, but occasional infection of germ line cells can lead to integrated retroviral genomes being vertically inherited as host alleles called endogenous retroviruses (ERVs). Once within the host germ line, retroviral genetic material can proliferate via a variety of mechanisms, giving rise to multi-copy 'families' of ERV sequences. ERVs serve as a kind of molecular 'fossil record' for the various forms of retroviruses that have that circulated throughout the Cenozoic Era. However, most ERV families are comprised entirely of sequences that have accumulated numerous mutations, deletions, and insertions. The use of ERVs to explore the biology of the ancient infectious retroviruses requires methods for 'paleovirological' reconstruction of ancestral retroviral genomes using highly mutated ERV sequences. For accurate reconstructions, methods must account not only for mutational changes that have occurred due to genetic drift during host DNA replication, but also for a range of additional factors that can influence the evolution of ERV sequences. These include; (i) host-mediated editing of retroviral sequences, (ii) methylation of CpG dinucleotides, and (iii) selection pressures that vary depending on the mechanism of ERV proliferation and the biological consequence of ERV expression in the host species. We describe a systematic approach to using ERV insertions for paleovirological reconstruction of ancestral, infectious retrovirus genome sequences. We use this approach to reconstruct ancestral genome sequences for 15 major human ERV (HERV) lineages. Using these reconstructed ancestral sequences, we re-evaluate the evolutionary relationships of HERVs and modern exogenous retroviruses, and estimate the time-period over which the exogenous viruses from which these 15 HERV lineages are derived are likely to have circulated amongst mammalian species.
Medullary stromal cells synergize their production and capture of CCL21 for T-cell emigration from neonatal mouse thymus (2021)

The release of newly selected αβT cells from the thymus is key in establishing a functional adaptive immune system. Emigration of the first cohorts of αβT cells produced during the neonatal period is of particular importance, because it initiates formation of the peripheral αβT-cell pool and provides immune protection early in life. Despite this, the cellular and molecular mechanisms of thymus emigration are poorly understood. We examined the involvement of diverse stromal subsets and individual chemokine ligands in this process. First, we demonstrated functional dichotomy in the requirement for CCR7 ligands and identified CCL21, but not CCL19, as an important regulator of neonatal thymus emigration. To explain this ligand-specific requirement, we examined sites of CCL21 production and action and found Ccl21 gene expression and CCL21 protein distribution occurred within anatomically distinct thymic areas. Although Ccl21 transcription was limited to subsets of medullary epithelium, CCL21 protein was captured by mesenchymal stroma consisting of integrin α7+ pericytes and CD34+ adventitial cells at sites of thymic exit. This chemokine compartmentalization involved the heparan sulfate-dependent presentation of CCL21 via its C-terminal extension, explaining the absence of a requirement for CCL19, which lacks this domain and failed to be captured by thymic stroma. Collectively, we identified an important role for CCL21 in neonatal thymus emigration, revealing the importance of this chemokine in initial formation of the peripheral immune system. Moreover, we identified an intrathymic mechanism involving cell-specific production and presentation of CCL21, which demonstrated a functional synergy between thymic epithelial and mesenchymal cells for αβT-cell emigration.
NorLeu 3 -Angiotensin (1-7) [DSC127] as a Therapy for the Healing of Diabetic Foot Ulcers (2015)

<b>Significance:</b> Diabetes is a disorder that is well known to delay wound repair resulting in the formation of colonized chronic wounds. Over their lifetime, diabetic patients have a 25% incidence of foot ulcers (DFUs), which contribute to increased risk of morbidity, including osteomyelitis and amputations, and increased burden to the healthcare system. <b>Recent Advances:</b> The only active product approved for the treatment of diabetic ulcers, Regranex<sup>®</sup>, is not widely used due to minimal proven efficacy and recent warnings added to the Instructions for Use. A novel topical agent that accelerates healing and increases the proportion of fully healed DFUs, DSC127 [aclerastide; active ingredient, NorLeu<sup>3</sup>-angiotensin (1-7) (NorLeu<sup>3</sup>-A(1-7))], is recruiting patients in Phase III clinical trials (NCT01830348 and NCT01849965). NorLeu<sup>3</sup>-A(1-7) is an analog of the naturally occurring peptide, angiotensin 1-7. The mechanisms of action include induction of progenitor proliferation, accelerated vascularization, collagen deposition, and re-epithelialization. <b>Critical Issues:</b> Current modalities for the treatment of DFUs include strict offloading, bandaging, debridement and, on a limited basis, application of Regranex. Novel potent therapies are needed to combat this significant burden to the diabetic patient and the healthcare system. <b>Future Direction:</b> Preclinical and clinical research shows that DSC127 is highly effective in the closure of diabetic wounds and is superior to Regranex in animal studies. Clinical development of DSC127 as a topical agent for the healing of DFU is underway. Further investigation into the mechanisms by which this product accelerates healing is warranted.
DEVELOPMENT OF A TEMPORARY BARRIER SYSTEM FOR OFF-ROAD APPLICATIONS (1998)

The safety shape portable concrete barrier (PCB) has been approved for use when placed on a bituminous or concrete pad. Construction personnel would like to use PCBs in temporary situations along roadways where the use of a bituminous or concrete pad is impractical and costly. However, when PCBs are placed on soil foundations with no anchorage, they tend to dig into the soil, causing the barrier sections to rotate or overturn. The objective of this research was to develop a device which will allow temporary PCBs placed on soil foundations to translate without significant rotation when impacted by errant vehicles. This device was developed and successfully tested to Test Level 3 of the National Cooperative Highway Research Program (NCHRP) Report No. 350.
Efficient fiber-chip coupling solutions for integrated mid-infrared nanophotonics (2019)

International audience
The nucleotide sequence and reading frames of a mutant hepatitis B virus subtypeadr (1989)

Journal Article The nucleotide sequence and reading frames of a mutant hepatitis B virus subtype adr Get access Hyune Mo Rho, Hyune Mo Rho * Laboratory of Molecular Genetics, Department of Zoology, Seoul National UniversitySeoul 151-742, Korea * To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar Keetae Kim, Keetae Kim Laboratory of Molecular Genetics, Department of Zoology, Seoul National UniversitySeoul 151-742, Korea Search for other works by this author on: Oxford Academic PubMed Google Scholar Sang Won Hyun, Sang Won Hyun Laboratory of Molecular Genetics, Department of Zoology, Seoul National UniversitySeoul 151-742, Korea Search for other works by this author on: Oxford Academic PubMed Google Scholar Yong Sole Kim Yong Sole Kim Laboratory of Molecular Genetics, Department of Zoology, Seoul National UniversitySeoul 151-742, Korea Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 17, Issue 5, 11 March 1989, Page 2124, https://doi.org/10.1093/nar/17.5.2124 Published: 11 March 1989 Article history Received: 06 February 1989 Published: 11 March 1989
Effects of Angiotensin II AT1-Receptor Blockade on Coronary Dynamics, Function, and Structure in Postischemic Heart Failure in Rats (2000)

Angiotensin II AT1-receptor blockers (AT1-s) prolong survival in experimental postischemic (coronary artery ligation) heart failure (CHF) in rats. The goal of this study was to investigate whether potential beneficial effects of short- and/or long-term treatment with AT1-s on coronary dynamics, function, and structure develop along with the drug-induced survival prolongation in this model. Coronary blood flow was measured (fluorescent microspheres) in conscious sham, untreated, and irbesartan-treated (50 mg/kg daily for 6 weeks or 6 months, starting 8 days after surgery) CHF rats at baseline and at maximal vasodilatation induced by dipyridamole, and coronary dilatation reserve (CDR) was calculated as the ratio of maximal to baseline coronary flow. Coronary endothelial function was assessed in vitro by measuring the coronary relaxant responses to acetylcholine in the three groups of animals. Finally, cardiac hypertrophy and pericoronary fibrosis also were investigated. In CHF rats, left (LV) and right (RV) ventricular CDR were markedly depressed at both 7 weeks and 6 months after ligation, whereas coronary endothelial function was significantly impaired only after 6 months. Short-term AT1-receptor blockade with irbesartan did not prevent CDR deterioration at 7 weeks, nor did it significantly oppose cardiac hypertrophy and pericoronary fibrosis development. Prolonged AT1-receptor blockade prevented both RV CDR deterioration and coronary endothelial function impairment. It also limited significantly the increase in LV end diastolic pressure and the development of cardiac hypertrophy and pericoronary fibrosis. In conclusion, in postischemic CHF in rats, alterations of CDR precede those of coronary endothelial function. Long-, but not short-term AT1-receptor blockade prevents endothelial function degradation, opposes RV CDR impairment, prevents pericoronary fibrosis development, and improves systemic hemodynamics. These effects of AT1-s on coronary dynamics, function, and structure (i.e., on myocardial perfusion) may contribute to the drug-induced survival prolongation in this model.
Dynamic link asymmetry in 'bunched' wireless networks (1999)

In most future wireless applications an increasing fraction of the total offered traffic is expected to appear in the downlink (fixed-to-mobile) segment of the system. This requirement matches rather poorly with the system design and spectrum allocation for current and future systems which employ symmetric frequency division duplex (FDD). In contrast, TDMA/TDD systems, at least in principle, allow for a more flexible resource allocation by moving the boundary between uplink and downlink time-slots, the switching point. The key problem caused by moving the switching point; is interference between mobiles and base stations. In the paper, some algorithms to select and adapt the switching point in a 'bunched' cellular environment are investigated. A simple scheme using a 'soft' switching point, is shown to provide a capacity, while not as high as a fully dynamic scheme, still considerably higher than the capacity of a traditional fixed switching point scheme. Further, the 'soft' scheme is also adaptive, in the sense that it tracks varying traffic asymmetry ratios.
Distributed dynamic energy resource control (2009)

In a shipboard power system, all components of the system, including sources, loads and distribution have multiple commitments and responsibilities. These commitments include serving the energy needs of a local load, but also maintaining the efficiency and stability of the overall system. This paper proposes a differential game-theoretic approach that uses a component's objective and operating characteristics to plan an optimal state trajectory without the need for extensive communication or centralized control.
Penile Transplantation: Lessons Learned and Technical Considerations (2022)

Though all 4 analyzed cases employed unique anastomotic and immunosuppressive approaches, 3 resulted in successful recovery of penile urinary and sexual function. Still, specific approaches used by different teams circumvented otherwise common complications, and these differences should guide future research and penile transplant cases.
Multiple metal-carbon bonds. 17. Preparation of monocyclopentadienyl benzylidene complexes of tantalum and the crystal structure of Ta(.eta.5-C5Me5)(CHPh)(CH2Ph)2 (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMultiple metal-carbon bonds. 17. Preparation of monocyclopentadienyl benzylidene complexes of tantalum and the crystal structure of Ta(.eta.5-C5Me5)(CHPh)(CH2Ph)2L. W. Messerle, P. Jennische, R. R. Schrock, and G. StuckyCite this: J. Am. Chem. Soc. 1980, 102, 22, 6744–6752Publication Date (Print):October 15, 1980Publication History Published online1 May 2002Published inissue 15 October 1980https://pubs.acs.org/doi/10.1021/ja00542a013https://doi.org/10.1021/ja00542a013research-articleACS PublicationsRequest reuse permissionsArticle Views309Altmetric-Citations71LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Diffraktive Multifokal Tecnis ZMB00 einteilige IOL: Optische Performance und Vergleich mit anderen asphärischen Multifokal-IOL (2010)

Fragestellung: Optische Performance der neuen Tecnis ZMB00 IOL im Vergleich zu anderen asphärischen diffraktiven IOLs in diversen Augenmodellen/Grün- und Weißlicht. Methodik: Die optische Performance der diffraktiven Multifokallinse Tecnis ZMB00 wird mit der ReSTOR SN5AD1; Acri.Lisa 356D und Crystalens HD500 IOLs verglichen. Zur optischen Messung dienen Modellaugen mit 3 verschiedenen künstlichen Korneas: 1. ISO (aberrationsfreie) Kornea; 2. Kornea mit 0,20 um sphärischer Aberration (SA) und 3. Physiologische Kornea mit 0,27 um SA. Der Einfluss der Pupillenweite wird durch MTF-Messungen und Visualisierung des Netzhautbilds von US Air Force Targetprojektionen im Nah- und Fernbrennpunkt in Grün- und Weißlicht gezeigt. Ergebnisse: Die Tecnis ZMB00 Linse hat hohe pupillenunabhängige nah- und fern MTF-Werte im Modellauge 2 und 3. Die Fern-MTF-Werte der ReSTOR und Acri.Lisa IOLs bei 3mm Pupillenweite sind auch vergleichsweise hoch, aber an allen Brennpunkten von der Pupillenweite abhängig. Die Crystalens (nur Fernbild messbar) zeigt einen hohen 3mm MTF-Wert. Der geringere 5mm MTF-Wert ist vergleichbar mit den Messwerten der ReSTOR und Acri.Lisa. Schlussfolgerungen: Die neue diffraktive Tecnis ZMB00 Multifokal-IOL hat hervorragende optische Performance, gleichmäßig auf Nah- und Fernbrennpunkt verteilt und unabhängig von der Pupillenweite.