gebhart/patrepeval huggingface dataset:
Abstract LB-236: Self-renewal of CD133hi cells by IL6/Notch3 signaling regulates endocrine resistance in metastatic breast cancers (2016)

Abstract The mechanisms of metastatic progression from hormonal therapy (HT)-induced tumour dormancy to hormonal therapy resistance is largely unknown in luminal breast cancer. Analysis of clinical specimens revealed the enrichment of CD133hi/ERlo cancer cells in primary tumours following neo-adjuvant endocrine therapy and in HT refractory metastatic disease. We developed spontaneous experimental models of metastatic luminal breast cancer and determined that endocrine therapy can promote the generation of HT- resistant, self-renewing CD133hi/ERlo/IL6hicells. Dual pharmacological inhibition of IL6R-IL6 (tocilizumab) and ER (HT) abrogated the establishment of CD133hi/ERlo/IL6hi cancer stem cells (CSCs), restoring endocrine sensitivity to hormone-refractory metastatic disease, in both experimental and patient-derived endocrine-resistant bone metastasis. Hormonal therapy, initially abrogated oxidative phosphorylation (OXPHOS) generating dormant (self-renewal deficient-CD133hi/ERlo/OXPHOSlo) cancer cells, These cells exited metabolic dormancy via an IL6 driven feed-forward ERlo-IL6hi-Notchhi loop, activating OXPHOS, in the absence of ER activity. Importantly, the inhibition of IL6R/IL6-Notch pathways switched the self-renewal of CD133hi CSCs, from an IL6/Notch-dependent one to an ER-dependent one, through the re-expression of ER. Thus, HT induces an OXPHOS metabolic editing of luminal breast cancers, paradoxically establishing HT-driven self-renewal of dormant CD133hi/ERlo cells mediating metastatic progression, which is sensitive to dual targeted therapy. Citation Format: Pasquale Sansone, Ceccarelli Claudio, Marjan Berishaj, Qing Chang, Rajasekhar Vinagolu, Fabiana Perna, Robert Bowman, Michele Vidone, Laura Daly, Jennifer Nnoli, Donatella Santini, Taffurelli Mario, Natalie Shih, Michael Feldman, Jun James Mao, Christopher Colameco, Jinbo Chen, Angela DeMichele, Nicola Fabbri, John Healey, Monica Cricca, Giuseppe Gasparre, David Lyden, Massimiliano Bonafe, Jacqueline F. Bromberg. Self-renewal of CD133hi cells by IL6/Notch3 signaling regulates endocrine resistance in metastatic breast cancers. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr LB-236.
Abstract WP558: Benefits of Perlecan Domain V in Diabetic Co-morbid Models of VCID (2019)

Introduction: Vascular contributions to cognitive impairment and dementia (VCID) are a major factor in the overall clinical burden of dementia. Besides aging, metabolic disorders such as type 2 diabetes complicate understanding of underlying mechanisms. Despite the complexity, we hypothesize that pathological changes in cerebrovascular extracellular matrix (ECM) are an underlying component of VCID that can be therapeutically targeted to reduce neurodegeneration and improve outcomes . One such ECM component, the terminal domain V (DV) of perlecan, greatly reduces amyloid toxicity and enhances angiogenic cerebrovascular remodeling. Methods: DV’s mechanism and therapeutic potential in facilitating Aβ clearance were examined in an ex vivo model of isolated mouse brain capillaries in normal and high glucose environments. We also determined the cerebrovascular changes in a comorbidity mouse model of VCID (diabetic APP/PS1 knock in (db/AD)) that is associated with hemorrhages, aneurysms, Aβ deposition, cognitive decline and increased mortality. Results: DV (300 and 600 nM) doubled the transport of fluorescently tagged hAβ1-42 over 24 hours from the bath (abluminal) to luminal side of the brain capillaries. One of Aβ’s known transport proteins, P-glycoprotein (P-gp), also increased in total protein expression and in transport activity in the presence of DV. At 3-6 months in db/AD mice, we observed a decrease in BBB proteins (claudin-5) indicating an altered cerebrovascular function correlating with DV expression increase during the asymptomatic angiogenic stage. At 9-12 months, cognitive changes were associated with altered cerebrovascular protein expression in PECAM, Collagen IV, and DV correlating with the aberrant two-photon vascular imaging, increased saccular aneurysms, and microhemorrhages. Conclusion: These data show that DV increases cerebrovascular Aβ clearance through P-gp. Increased DV expression correlates with early cerebrovascular changes induced by angiogenic-remodeling in a diabetic co-morbid mouse model of VCID. Lower DV expression is associated with aberrant vasculature that contribute to increased mortality, suggesting that DV ‘replacement therapy’ could represent a novel therapeutic for VCID.
Mining Social Media: A Brief Introduction (2012)

TutORials in Operations Research is a collection of tutorials published annually and designed for students, faculty, and practitioners. The series provides in-depth instruction on significant operations research topics and methods. INFORMS has published the series, founded by Harvey J. Greenberg, since 2005.
Rare Earth– and Transition Metal–Doped Amorphous Oxide Semiconductor Phosphors for Novel Light‐Emitting Diode Displays (2022)

Rare earth–doped amorphous oxide semiconductors (AOSs) enable room-temperature fabrication of inorganic light-emitting phosphors on a glass substrate. These AOS-based inorganic phosphor films possess clear advantages against organic semiconductors for light-emitting device applications, such as high optical transparency, much higher electron mobility, low defect densities, and good compatibility with low-temperature fabrication processes. This chapter compares several AOS host materials and dopants, including rare earth and transition metal elements. Although further improvement of luminance efficiency is necessary, the multicolor light emission realized in amorphous gallium oxide will lead to developing AOS-based self-emitting devices.
Design of a differentially flat 3R planar under-actuated manipulator with a single input at the second joint (2011)

In contrast to a fully actuated system, an under-actuated system cannot execute all joint trajectories. However, under-actuation may be unavoidable at times, such as during joint failure. In recent literature, an under-actuated open-chain planar manipulator with revolute joints has been shown to be feedback linearizable with specific choices of mass and inertia distribution. It has been shown that the dynamic model of an n-joint manipulator with center of mass located at joint 2 and with only one actuator is static feedback linearizable if and only if the input is at the first or the last joint. In our pursuit for novel designs of under-actuated arms, which are both controllable and feedback linearizable, we investigate the feasibility of designing a 3R planar under-actuated manipulator which has a different distribution of compliance. This study shows that this new architecture of 3R planar under-actuated manipulator with one input at the second joint can still be designed to be differentially flat. With this design, a simple stabilizing controller in the flat output space enables the system to perform point-to-point motion and mitigate initial errors.
Tin-Doped Inorganic Amorphous Films for Use as Transparent Monolithic Phosphors (2015)

Although inorganic crystalline phosphors can exhibit high quantum efficiency, their use in phosphor films has been limited by a reliance on organic binders that have poor durability when exposed to high-power and/or high excitation energy light sources. To address this problem, Sn(2+)-doped transparent phosphate films measuring several micrometers in thickness have been successfully prepared through heat treatment and a subsequent single dip-coating process. The resulting monolithic inorganic amorphous film exhibited an internal quantum efficiency of over 60% and can potentially utilize transmitted light. Analysis of the film's emissivity revealed that its color can be tuned by changing the amount of Mn and Sn added to influence the energy transfer from Sn(2+) to Mn(2+). It is therefore concluded that amorphous films containing such emission centers can provide a novel and viable alternative to conventional amorphous films containing crystalline phosphors in light-emitting devices.
RanStop: A Hardware-assisted Runtime Crypto-Ransomware Detection Technique (2020)

Among many prevailing malware, crypto-ransomware poses a significant threat as it financially extorts affected users by creating denial of access via unauthorized encryption of their documents as well as holding their documents hostage and financially extorting them. This results in millions of dollars of annual losses worldwide. Multiple variants of ransomware are growing in number with capabilities of evasion from many anti-viruses and software-only malware detection schemes that rely on static execution signatures. In this paper, we propose a hardware-assisted scheme, called RanStop, for early detection of crypto-ransomware infection in commodity processors. RanStop leverages the information of hardware performance counters embedded in the performance monitoring unit in modern processors to observe micro-architectural event sets and detects known and unknown crypto-ransomware variants. In this paper, we train a recurrent neural network-based machine learning architecture using long short-term memory (LSTM) model for analyzing micro-architectural events in the hardware domain when executing multiple variants of ransomware as well as benign programs. We create timeseries to develop intrinsic statistical features using the information of related HPCs and improve the detection accuracy of RanStop and reduce noise by via LSTM and global average pooling. As an early detection scheme, RanStop can accurately and quickly identify ransomware within 2ms from the start of the program execution by analyzing HPC information collected for 20 timestamps each 100us apart. This detection time is too early for a ransomware to make any significant damage, if none. Moreover, validation against benign programs with behavioral (sub-routine-centric) similarity with that of a crypto-ransomware shows that RanStop can detect ransomware with an average of 97% accuracy for fifty random trials.
Demonstration of a Tunable Microwave-Photonic Notch Filter Using Low-Loss Silicon Ring Resonators (2009)

We present a fully tunable multistage narrowband optical pole-zero notch filter that is fabricated in a silicon complementary metal oxide semiconductor (CMOS) foundry. The filter allows for the reconfigurable and independent tuning of the center frequency, null depth, and bandwidth for one or more notches simultaneously. It is constructed using a Mach-Zehnder interferometer (MZI) with cascaded tunable all-pass filter (APF) ring resonators in its arms. Measured filter nulling response exhibits ultranarrow notch 3 dB BW of 0.6350 GHz, and nulling depth of 33 dB. This filter is compact and integrated in an area of 1.75 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . Using this device, a novel method to cancel undesired bands of 3 dB bandwidth of < 910 MHz in microwave-photonic systems is demonstrated. The ultranarrow filter response properties have been realized based on our developed low-propagation loss silicon channel waveguide and tunable ring-resonator designs. Experimentally, they yielded a loss of 0.25 dB/cm and 0.18 dB/round trip, respectively.
Sequence analysis reveals new membrane anchor of reaction centre‐bound cytochromes possibly related to PufX (2003)

Most of the bacterial photosynthetic reaction centres known to date contain a cytochrome subunit with four covalently bound haem groups. In the case of Blastochloris viridis, this reaction centre subunit is anchored in the membrane by a lipid molecule covalently attached to the cysteine which forms the N-terminus of the mature protein after processing by a signal peptidase. We show that posttranslational N-terminal cleavage of the cytochrome subunit does not occur in the aerobic photosynthetic bacterium Roseobacter denitrificans. From sequence analysis of the resulting elongated N-terminus it follows that a transmembrane helix is anchoring the reaction centre-bound cytochrome in the membrane. Comparative sequence analysis strongly suggests that all cytochrome subunits lacking the lipid coupling cysteine share this structural feature. Comparison of the N-terminal segment of the cytochrome subunit of Roseobacter denitrificans with the sequences of the PufX proteins from Rhodobacter sphaeroides and Rhodobacter capsulatus suggests a phylogenetic relation.
Data from Efficient <i>In vivo</i> Priming by Vaccination with Recombinant NY-ESO-1 Protein and CpG in Antigen Naïve Prostate Cancer Patients (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; NY-ESO-1, one of the most immunogenic tumor antigens, is expressed in 15% to 25% of metastatic prostate cancers. The immunological and clinical effects of vaccination with recombinant NY-ESO-1 protein combined with CpG as adjuvant were evaluated.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; In a phase I clinical study, patients with advanced prostate cancer were vaccinated with recombinant NY-ESO-1 protein (100 μg) mixed with CpG 7909 (2.5 mg) every 3 weeks intradermally for 4 doses. Objectives of the study were the safety of the vaccine and changes of specific humoral and cellular immunological responses to NY-ESO-1 in relation to detectable NY-ESO-1 expression in the individual tumor.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; All 12 baseline sero-negative patients developed high-titer NY-ESO-1 antibody responses. B-cell epitope mapping identified NY-ESO-1 p91–110 to be recognized most frequently by vaccine-induced antibodies. Two patients developed significant antibody titers against the adjuvant CpG. NY-ESO-1-specific CD4+ and/or CD8+ T-cell responses were induced in 9 patients (69%). Five of these 9 patients did not express NY-ESO-1 in the autologous tumor. Postvaccine CD8+ T-cell clones recognized and lyzed HLA-matched tumor cell lines in an antigen-specific manner.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusion:&lt;/b&gt; Our data provide clear evidence for the capacity of NY-ESO-1 protein/CpG vaccine to induce integrated antigen-specific immune responses &lt;i&gt;in vivo&lt;/i&gt; and to efficiently prime CD8+ T-cell responses in NY-ESO-1 antigen-negative patients. Our results may also support further clinical vaccination protocols with NY-ESO-1 protein not only focused on the treatment of existing cancer, but also to prevent further development of NY-ESO-1 positive cancers &lt;i&gt;in vivo&lt;/i&gt;. &lt;i&gt;Clin Cancer Res; 17(4); 1–10. ©2010 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Somatic cell reprogramming for regenerative medicine: SCNT vs. iPS cells (2012)

Reprogramming of somatic cells to a pluripotent state holds huge potentials for regenerative medicine. However, a debate over which method is better, somatic cell nuclear transfer (SCNT) or induced pluripotent stem (iPS) cells, still persists. Both approaches have the potential to generate patient-specific pluripotent stem cells for replacement therapy. Yet, although SCNT has been successfully applied in various vertebrates, no human pluripotent stem cells have been generated by SCNT due to technical, legal and ethical difficulties. On the other hand, human iPS cell lines have been reported from both healthy and diseased individuals. A recent study reported the generation of triploid human pluripotent stem cells by transferring somatic nuclei into oocytes, a variant form of SCNT. In this essay, we discuss this progress and the potentials of these two reprogramming approaches for regenerative medicine.
Combustion Characteristics of Stoichiometric Al-CuO Nanocomposite Thermites Prepared by Different Methods (2016)

Three nanocomposite materials with the same nominal stoichiometric thermite composition of 2Al-3CuO were prepared by three different methods: ultrasonic mixing (USM) of constituent nanopowders, electrospraying (ES), and arrested reactive milling (ARM). Prepared powders were placed in a 6.7-mm diameter, 0.5-mm-deep cavity in a brass substrate and ignited by electro-static discharge. The experiments were performed in air, argon, and helium. The mass of powder removed from the sample holder after ignition was measured in each test. Using a multi-anode photo-multiplier tube coupled with a spectrometer, time-resolved light emission traces produced by the ignited samples were recorded in the range of wavelengths of 373–641 nm. Time-resolved temperatures were then determined by fitting the recorded spectra assuming Planck’s black body emission. Temporal pressure generated by ignition events in the enclosed chamber showed that the powder’s combustion properties were tied to both their preparation technique as well as the environment they were ignited in. We found that agglomeration of nanoparticles hindered combustion of USM powders; while it was not observed for the ES powders. In oxygen-free gas environments, lower temperatures and pressures were observed for USM and ES powders prepared using starting nano-particles. For the ES powders, the effect of gas environment was less significant, which was interpreted considering that ES materials included gasifying nitrocellulose binder, enhancing heat, and mass transfer between individual Al and CuO particles. Higher pressures and temperatures were observed in inert environments for the ARM-prepared powder.
Cytokines Profile in Experimental Biliary Obstruction (1996)

Der Verschluβikterus wird von der Unterdrückung des Immunsystems begleitet, wobei der genaue Mechanismus dieses Phänomens noch unbekannt ist. Auch eine Verschlechterung der Funktion von Lymphozyten, Neutrophilen und Makrophagen wurde beschrieben. Ziel der vorliegenden Studie war es deshalb, die Wirkung des Verschluβikterus auf die IL-2- und IL-3-Produktion zu untersuchen, wobei Splenozyten von C 7B1/6J-Mäusen verwendet wurden. In den Tieren wurde durch eine Gallengangligation, die nachfolgend durch eine interne Gallendrainage versorgt wurde, ein Gallenverschluβ hervorgerufen. Die Mäuse wurden am 7., 14. und 21. Tag nach der Gallengangligatur und 60 Tage nach der internen Gallendrainage getötet. Die Gallenobstruktion rief eine statistisch signifikante progressive Hemmung der IL-2-Produktion am 14. und 21. Tag nach der Ligatur hervor. Eine statistisch signifikante Unterdrückung der IL-3-Bildung fanden wir am 7., 14. und 21. Tag nach der Ligatur. Die Hemmung beider Interleukine war teilweise reversibel nach der internen Gallendrainage. Die Ergebnisse dieser Studien weisen die schädigende Funktion verschiedener Komponenten des Immunsystems bei Gallenobstruktion nach.
Homoleptic Ir(III) Phosphors with 2-Phenyl-1,2,4-triazol-3-ylidene Chelates for Efficient Blue Organic Light-Emitting Diodes (2021)

In this report, we synthesized two series of deep-blue-emitting homoleptic iridium(III) phosphors bearing 1,2,4-triazol-3-ylidene and 5-(trifluoromethyl)-1,2,4-triazol-3-ylidene cyclometalate. Compared with reported synthetic routes using Ag<sub>2</sub>O as the promoter, herein, we adopted a different strategy to furnish these complexes in high yields. Also, the meridional to facial isomerization was executed in the presence of trifluoroacetic acid. These phosphors were examined using NMR spectroscopies, single-crystal X-ray diffraction studies, and photophysical methods. The results revealed that electron-withdrawing trifluoromethyl substitution on the N-heterocyclic carbene fragment only gave a minor variation of photoluminescence peak wavelengths and a decrease in radiative lifetime but notable reduction in thermal stabilities. The parent 1,2,4-triazol-3-ylidene complexes have been demonstrated to be suitable for use as deep-blue phosphors, with structured emission with the peak max. located at ∼420 nm and with photoluminescence quantum yields in a range of 34.8-42.5% in degassed THF solution at RT. Fabrication of both the phosphorescent organic light-emitting diodes (OLEDs) and phosphor-sensitized OLEDs (or hyperphosphorescence) was successfully conducted, from which the OLED device based on <b><i>m</i>-tz1</b> showed a max. external quantum efficiency (EQE) of 10% with CIE<sub><i>x</i>,<i>y</i></sub> coordinates of 0.15, 0.06, while the corresponding hyperphosphorescent OLED using <b><i>m</i>-tz2</b> as a sensitizer and <i>t</i>-DABNA as a terminal emitter afforded a significantly improved max. EQE of 19.7%, EL λ<sub>max</sub> of 468 nm, and FWHM of 31 nm with CIE<sub><i>x</i>,<i>y</i></sub> coordinates of 0.12, 0.13.
Supplementary Figure S2 from p95HER2 Methionine 611 Carboxy-Terminal Fragment Is Predictive of Trastuzumab Adjuvant Treatment Benefit in the FinHer Trial (2023)

&lt;p&gt;Supplementary Figure 2&lt;/p&gt;
Feature extraction and classification models for high‐dimensional profile data (2011)

Abstract As manufacturing transitions to real‐time sensing, it becomes more important to handle multiple, high‐dimensional (non‐stationary) time series that generate thousands of measurements for each batch. Predictive models are often challenged by such high‐dimensional data and it is important to reduce the dimensionality for better performance. With thousands of measurements, even wavelet coefficients do not reduce the dimensionality sufficiently. We propose a two‐stage method that uses energy statistics from a discrete wavelet transform to identify process variables and appropriate resolutions of wavelet coefficients in an initial (screening) model. Variable importance scores from a modern random forest classifier are exploited in this stage. Coefficients that correspond to the identified variables and resolutions are then selected for a second‐stage predictive model. The approach is shown to provide good performance, along with interpretable results, in an example where multiple time series are used to indicate the need for preventive maintenance. In general, the two‐stage approach can handle high dimensionality and still provide interpretable features linked to the relevant process variables and wavelet resolutions that can be used for further analysis. Copyright © 2011 John Wiley &amp; Sons, Ltd.
10.1162/153244303321897717 (2000)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Complex Intrachromosomal Rearrangement in the Process of Amplification of the L-myc Gene in Small-Cell Lung Cancer (1992)

The L-myc gene was first isolated from a human small-cell lung cancer (SCLC) cell line on the basis of its amplification and sequence similarity to c-myc and N-myc. A new mechanism of L-myc activation which results from the production of rlf-L-myc fusion protein was recently reported. On the basis of our earlier observation of a rearrangement involving amplified L-myc in an SCLC cell line, ACC-LC-49, we decided to investigate this rearrangement in detail along with the structure of L-myc amplification units in five additional SCLC cell lines. We report here the identification of a novel genomic region, termed jal, which is distinct from rlf and is juxtaposed to and amplified with L-myc during the process of DNA amplification of the region encompassing L-myc. Long-range analysis using pulsed-field gel electrophoresis revealed that the amplified L-myc locus is involved in highly complex intrachromosomal rearrangements with jal and/or rlf. Our results also suggest that the simultaneous presence of rearrangements both in rlf intron 1 and in regions immediately upstream of L-myc may be necessary for the expression of rlf-L-myc chimeric transcripts.