gebhart/patrepeval huggingface dataset:
Melanoma tumour-bearing mice exhibit cardiac wasting and reduced myocardial 18F-deoxyglucose uptake without impairment of insulin-dependent glucose transport. (2015)

517 Objectives Advanced cancer induces general cachexia and may contribute to cardiac wasting and failure. Preterminal melanoma bearing mice exhibit cardiac atrophy and impaired contractile function. The role of abnormal glucose metabolism was assessed by 18F-deoxyglucose uptake and insulin signaling in isolated adult cardiomyocytes and in vivo in mice. Methods C57Bl/6 mice were administered B16F10 melanoma cells (n=15) or vehicle (n=4). Mice underwent serial FDG PET scans at baseline and 11-14d after cell injection. Cardiomyocytes were isolated from B16F10 and control mice for FDG uptake assay. To determine insulin response in vivo, dynamic FDG PET images were acquired on consecutive days with or without insulin pretreatment (6mU/g). Plasma insulin was measured by ELISA and glucose transporters by immunoblot. Results Significant cancer-related mortality was found at 14-21d (28-54%). B16F10-bearing mice exhibited impaired contractile function (fractional shortening, 23±10 vs 39±8%, p Conclusions Rapidly progressive B16F10 tumour appears to interfere with insulin signaling and diverts glucose away from cardiomyocytes, despite maintained myocardial insulin sensitivity. Lack of insulin availability, rather than insulin resistance, contributes to terminal cancer-induced cardiac wasting and failure.
Polygon rendering on a stream architecture (2000)

The use of a programmable stream architecture in polygon rendering provides a powerful mechanism to address the high performance needs of today's complex scenes as well as the need for flexibility and programmability in the polygon rendering pipeline. We describe how a polygon rendering pipeline maps into data streams and kernels that operate on streams, and how this mapping is used to implement the polgyon rendering pipeline on Imagine, a programmable stream processor. We compare our results on a cycle-accurate simulation of Imagine to representative hardware and software renderers.
The Consortium for the early identification of Alzheimer's disease–Quebec (CIMA‐Q) (2019)

CIMA-Q provides procedures and resources to identify early biomarkers and novel therapeutic targets, and holds promise for detecting cognitive decline in Alzheimer's disease.
Functional analysis of BBS3 A89V that results in non-syndromic retinal degeneration (2011)

Bardet -Biedl syndrome (BBS) is a syndromic form of retinal degeneration. Recently, homozygosity mapping with a consanguineous family with isolated retinitis pigmentosa identified a missense mutation in BBS3, a known BBS gene. The mutation in BBS3 encodes a single amino acid change at position 89 from alanine to valine. Since this amino acid is conserved in a wide range of vertebrates, we utilized the zebrafish model system to functionally characterize the BBS3 A89V mutation. Knockdown of bbs3 in zebrafish alters intracellular transport, a phenotype observed with knockdown of all BBS genes in the zebrafish, as well as visual impairment. Here, we find that BBS3 A89V is sufficient to rescue the transport delays induced by the loss of bbs3, indicating that this mutation does not affect the function of BBS3 as it relates to syndromic disease. BBS3L A89V, however, was unable to rescue vision impairment, highlighting a role for a specific amino acid within BBS3 that is necessary for visual function, but dispensable in other cell types. These data aid in our understanding of why patients with the BBS3 A89V missense mutation only present with isolated retinitis pigmentosa.
Crowd-sourced calibration of uncontrolled radiation detectors (2012)

Image Insight Inc. recently released an Android application (GammaPix Lite™) that uses smartphone cameras for radiation detection and measurement. Given the wide diversity of smartphones in use, and the frequent release of new models, traceable calibrations of all the devices on which the app could possibly run is clearly not practical. In this paper, we discuss the methods we have developed to address this problem by using data gathered from multiple instances of each device in uncalibrated use. The quality control mechanisms, reference material, and resulting calibrations are discussed in this paper.
Optical lithography—present and future challenges (2006)

Optical lithography has been an industrial workhorse for many decades. It has reached a wavelength of 193 nm, a Numerical Aperture (NA) of 0.93 but was facing difficulties to advance further until the debut of immersion lithography. This review deals with the limit of dry and immersion lithography systems, their present and future challenges to reach these very limits. A discussion of defects in immersion lithography, the status of immersion lithography, polarized illumination, high-index materials, solid-immersion mask, double exposure and double patterning is included.
Enhanced selection of high affinity DNA-reactive B cells following cyclophosphamide treatment (99.40) (2009)

Abstract A major goal for the treatment of SLE patients with cytotoxic therapies is the induction of long term remission. There is, however, a paucity of information concerning the effects of these therapies on the reconstituting B cell repertoire. Since there is recent evidence suggesting that B cell lymphopenia might attenuate negative selection of autoreactive B cells, we elected to investigate the effects cyclophosphamide (CY) on the selection of the re-emerging B cell repertoire in transgenic mice that express the H chain of an anti-DNA antibody (R4A-Tg). The reconstituting B cell repertoire contained an increased frequency of mature, high affinity DNA-reactive B cells as determined by single cell PCR analysis, and the mice expressed increased levels of serum anti-DNA antibodies. This coincided with a significant increase in levels of BAFF, a B cell survival factor. Treatment with BAFF-R-Ig, a BAFF blocking agent or with DNase, to reduce exposure to autoantigen, limited the expansion of high affinity DNA-reactive B cells during B cell reconstitution. These studies suggest that during B cell reconstitution, negative selection of high affinity DNA-reactive B cells is impaired by increased BAFF. B cells escaping negative selection are positively selected by autoantigen. BAFF blockade following treatment with B cell depleting agents may be useful for the successful long-term remission of SLE.
Beating effects in multilayer systems studied with neutron reflectometry (2018)

We demonstrate the limitations of a partial, phenomenological tting approach comparedto full simulations, including reection and refraction at all interfaces on theexample of hydrogen loading in ul ...
Oxidation Resistance of Fully Dense ZrB 2 with SiC, TaB 2 , and TaSi 2 Additives (2008)

Specimens of ZrB 2 containing various concentrations of B 4 C, SiC, TaB 2 , and TaSi 2 were pressureless‐sintered and post‐hot isostatic pressed to their theoretical densities. Oxidation resistances were studied by scanning thermogravimetry over the range 1150°–1550°C. SiC additions improved oxidation resistance over a broadening range of temperatures with increasing SiC content. Tantalum additions to ZrB 2 –B 4 C–SiC in the form of TaB 2 and/or TaSi 2 increased oxidation resistance over the entire evaluated spectrum of temperatures. TaSi 2 proved to be a more effective additive than TaB 2 . Silicon‐containing compositions formed a glassy surface layer, covering an interior oxide layer. This interior layer was less porous in tantalum‐containing compositions.
Mid-rapidity anti-baryon to baryon ratios in pp collisions at $\sqrt{s} = 0.9,\ 2.76\mbox{ and }7\mbox{ TeV}$ measured by ALICE (2013)

The ratios of yields of anti-baryons to baryons probes the mechanisms of baryon-number transport. Results\nfor anti-p/p, anti-lambda/lambda, anti-xi+/xi-, e antiomega+/omega- in pp collisions at √s = 0.9, 2.76 and 7 TeV, measured with the ALICE detector at the LHC, are reported. Within the experimental uncertainties and ranges covered by our measurement, these ratios are independent of rapidity, transverse momentum and multiplicity for all measured energies. The results are compared to expectations from event generators, such as PYTHIA and HIJING/B, that are used to model the particle production in pp collisions. The energy dependence of anti-p/p, anti-lambda/lambda, anti-xi+/xi-, e antiomega+/omega- , reaching values compatible with unity for √s = 7 TeV, complement the earlier anti-p/p measurement of ALICE. These dependencies can be described by exchanges with the Regge-trajectory intercept of αJ ≈ 0.5, which are suppressed with increasing rapidity interval Delta-y. Any significant contribution of an exchange not suppressed at large delta-y (reached at LHC energies) is disfavoured.
Switchable Motion Models for Non-Block-Based Inter Prediction in Learning-Based Video Coding (2021)

Most state-of-the-art video coders rely on a block structure. For inter-frame prediction, motion vectors are transmitted per block. For example in VVC, the coder can choose between a translational or an affine motion model on a block level, depending on the content. In non-block-based coding, which is on the rise since the development of end-to-end learning based image compression, the motion vectors have to be transmitted differently. Due to the missing inherent block structure, switching between different motion models presents a challenge, but also an opportunity. In this paper, we propose an alternative approach to efficiently signal additional information regarding the motion model to improve the quality of the motion compensated image. Using our methods, we are able to increase the quality of the prediction image in our scenario by 0.40 dB on average and by up to 0.88 dB for sequences with strong and complex motion at the same rate.
Vertical Conductivity and Topography in Electrostrictive Germanium Sulfide Microribbon via Conductive Atomic Force Microscopy (2022)

Layered group IV monochalcogenides are two-dimensional (2D) semiconducting materials with unique crystal structures and novel physical properties. Here, we report the growth of single crystalline GeS microribbons using the chemical vapor transport process. By using conductive atomic force microscopy, we demonstrated that the conductive behavior in the vertical direction was mainly affected by the Schottky barriers between GeS and both electrodes. Furthermore, we found that the topographic and current heterogeneities were significantly different with and without illumination. The topographic deformation and current enhancement were also predicted by our density functional theory (DFT)-based calculations. Their local spatial correlation between the topographic height and current was established. By virtue of 2D fast Fourier transform power spectra, we constructed the holistic spatial correlation between the topographic and current heterogeneity that indicated the diminished correlation with illumination. These findings on layered GeS microribbons provide insights into the conductive and topographic behaviors in 2D materials.
[Foreword] Welcome to the Special Section on Digital Museum Technology (2014)

Recent progress in digital technology made media technology applicable to museums which have been the places, for a long period of time, where people meet physical social archives.Museums show not only physical objects, but also events in the past.They have relied on traditional way of exhibition which does not include information technology.Digital technology could improve existing museums in two ways.One is advancing visitors' experiences by introducing information technology in the exhibitions such as mixed reality.The other is improvement of management of museums by monitoring visitors so that new aspects of visitors' behaviors could be found.Thus, there are many potential research topics in digital museum technology.In this special section, we have received thirteen papers and finally accepted seven papers.
Reduction of focal-spot size using dichromats in absorbance modulation (2008)

We experimentally verify the focusing characteristics of dichromats, a new class of circular-symmetric diffractive-optical lenses that generate, in the same focal plane, focal spots for one wavelength and ring-shaped spots with central nodes for another wavelength. Using a dichromat, we illuminate a thin photochromic layer and demonstrated point-spread-function compression of the transmitted focal spot.
Tissue engineering, stem cells, cloning, and parthenogenesis: new paradigms for therapy (2004)

: BACKGROUND: Patients suffering from diseased and injured organs may be treated with transplanted organs. However, there is a severe shortage of donor organs which is worsening yearly due to the aging population. Scientists in the field of tissue engineering apply the principles of cell transplantation, materials science, and bioengineering to construct biological substitutes that will restore and maintain normal function in diseased and injured tissues. Both therapeutic cloning (nucleus from a donor cell is transferred into an enucleated oocyte), and parthenogenesis (oocyte is activated and stimulated to divide), permit extraction of pluripotent embryonic stem cells, and offer a potentially limitless source of cells for tissue engineering applications. The stem cell field is also advancing rapidly, opening new options for therapy. The present article reviews recent progress in tissue engineering and describes applications of these new technologies that may offer novel therapies for patients with end-stage organ failure.
Synthese Pyridin-analoger Tetrahydrocannabinol / Synthesis of Pyridine-analogous Tetrahydrocannabinols (1979)

Abstract Starting from 4-methylpyridine a 3-aza-Δ 8 -tetrahydrocannabinol-analogous (2d) was prepared. The reaction sequence also includes the first synthesis of a 6 H-benzo(4,5)-pyrano(2,3-c)-pyridin-6-on, a novel ring-system. The proposed structures were supported by spectroscopic data ( 1 H NMR, IR, MS).
Volumetric Electron Transfer from Metabolites to Chemically Doped Polymer Electrodes (2023)

Abstract The development of sensor electrode materials for the detection of metabolites will enable point‐of‐care diagnostic devices for the monitoring and treatment of metabolic diseases such as diabetes. Current state‐of‐the‐art glucose sensing electrodes employ the organic salt tetrathiafulvene tetracyanoquinodimethane (TTF TCNQ) to receive electrons directly from enzymatic reactions of glucose. However, TTF TCNQ is insoluble in most solvents, making it challenging to deposit high‐quality electrodes. Furthermore, its hydrophobicity hinders its interface with aqueous solutions in physiological environments. To overcome these issues, TCNQ derivatives are introduced into an electron‐rich and hydrophilic conjugated polymer. Thus, a polymeric electrode is demonstrated that is easily solution processible and can undergo volumetric direct electron transfer with glucose reactions throughout its bulk. This study further elucidates the electron transfer mechanism during chemical doping and metabolite sensing reactions to inform general design rules for this new class of glucose sensing materials.
The GDP Exchange Factor AND-34 Is Expressed in B Cells, Associates With HEF1, and Activates Cdc42 (2003)

AND-34, a novel GDP exchange factor, is expressed constitutively at significant levels in murine splenic B cells, but not in murine splenic T cells or thymocytes. In B cell lines, anti-IgM treatment up-regulates AND-34 transcript levels. B cell AND-34 associates with both the docking molecules p130Cas and HEF1. AND-34 binds by its GDP exchange factor domain to the C terminus of HEF1, a region of HEF1 previously implicated in apoptotic, adhesion, and cell cycle-regulated signaling. Overexpression of AND-34 in murine B cell lines activates the Rho family GTPase Cdc42, but not Rac, Rho, RalA, or Rap1. Consistent with this, a subpopulation of AND-34 overexpressing B cells have long filamentous actin-containing cellular extensions. AND-34 overexpression augments both autophosphorylation and kinase activity of the Cdc42/Rac-responsive serine/threonine kinase PAK1. As previously reported for lymphoid cells transfected with constitutively active Cdc42, AND-34 overexpression inhibits SDF-1alpha-induced B cell polarization. These studies suggest that p130Cas and HEF1-associated AND-34 may regulate B cell adhesion and motility through a Cdc42-mediated signaling pathway.
Oxygen Concentration Control of Dopamine-Induced High Uniformity Surface Coating Chemistry (2012)

Material surface engineering has attracted great interest in important applications, including electronics, biomedicine, and membranes. More recently, dopamine has been widely exploited in solution-based chemistry to direct facile surface modification. However, unsolved questions remain about the chemical identity of the final products, their deposition kinetics and their binding mechanism. In particular, the dopamine oxidation reaction kinetics is a key to improving surface modification efficiency. Here, we demonstrate that high O(2) concentrations in the dopamine solution lead to highly homogeneous, thin layer deposition on any material surfaces via accelerated reaction kinetics, elucidated by Le Chatelier's principle toward dopamine oxidation steps in a Michael-addition reaction. As a result, highly uniform, ultra-smooth modified surfaces are achieved in much shorter deposition times. This finding provides new insights into the effect of reaction kinetics and molecular geometry on the uniformity of modifications for surface engineering techniques.
Flavonoid-lnduced Gastroprotection in Rats: Role of Blood Flow and Leukocyte Adherence (1997)

To elucidate the mechanisms of flavonoid-induced protection against nonsteroidal anti-inflammatory drug (indomethacin)-induced acute gastric damage, the effects of 5-methoxyflavone and 5-methoxyflavanone on the gastric vasculature were compared both in vivo (using laser Doppler flowmetry in anesthetized rats) and in vitro on rat superior mesenteric arteries. The effects of the compounds on indomethacin-induced leukocyte adherence to mesenteric venules were investigated by intravital videomicroscopy. Oral 5-methoxyflavone reduced indomethacin-induced macroscopic damage by 38 to 99% (ED50 = 5.5 mg/kg). Damage was not significantly reduced by 5-methoxyflavanone. Light microscopy studies also demonstrated a reduction in damage severity. 5-Methoxyflavone, but not 5-methoxyflavanone, increased the gastric conductance significantly. The effects on isolated mesenteric arteries correlated with the effects on in vivo conductance. Finally, indomethacin-induced leukocyte adherence was inhibited to a greater extent by 5-methoxyflavone than by 5-methoxyflavanone. In conclusion, the flavonoid 5-methoxyflavone provides gastroprotection against nonsteroidal anti-inflammatory drug-induced gastric damage. A structurally similar compound, 5-methoxyflavanone, demonstrated minimal gastroprotective activity, suggesting that the double bond of 5-methoxyflavone is required for biological activity. The finding that 5-methoxyflavone (but not 5-methoxyflavanone) significantly increased gastric vascular perfusion and reduced leukocyte adherence to mesenteric venules suggests that these mechanisms may contribute to the flavonoid's gastroprotective activity.
Substrates and ESD (2004)

This chapter contains sections titled: Methods of Substrate Analysis Substrate As a Semi-infinite Domain Substrate As a Stratified Medium Using the Transfer Matrix Approach Substrate Transmission Line Model Substrate Lossy Transmission Line Models Substrate Absorption, Reflection and Transmission Substrate Electrical and Thermal Discretization Substrate Effects: Electrical Transfer Resistance Substrate Effects: Thermal Transfer Resistance Substrate Thermal Resistance Models Heavily Doped Substrates Low-doped Substrates Problems References
Radar-Based Non-intrusive Fall Motion Recognition using Deformable Convolutional Neural Network (2019)

Radar is an attractive sensing technology for remote and non-intrusive human health monitoring and elderly fall detection due to its ability to work in low lighting conditions, its invariance to the environment, and its ability to operate through obstacles. Radar reflections from humans produce unique micro-Doppler signatures that can be used for classifying human activities and fall motion. However, radar-based elderly fall detection need to handle the indistinctive inter-class differences and large intra-class variations of human fall-motion in a real-world situation. Further, the radar placement in the room and varying aspect angle of the falling subject could result in differing radar micro-Doppler signature of human fall-motion. In this paper, we use a compact short-range 60-GHz frequency modulated continuous wave radar for detecting human fall motion using a novel deformable deep convolutional neural network with novel 1-class contrastive loss function in conjunction to focus loss to recognize elderly fall and address several of these signal processing system challenges. We demonstrate the performance of our proposed system in laboratory conditions under staged fall motion.
An outstanding effect of graphite in nano-MgH2–TiH2 on hydrogen storage performance (2018)

Mg nanoparticles in Mg–Ti–C do not sinter but, on the contrary, are further refined thus dramatically improving the cycle stability.
[Development of a device allowing for the perfusion and preservation of rat kidneys at -4 degrees C]. (1996)

In animals, it is possible to store kidneys at a temperature of -4 degrees C for 96 hours by using a vecor solution (UW solution) and a cryoprotective agent (2,3 butanediol). The perfusion and storage of organs under these conditions must be performed by a computer-assisted machine, allowing monitoring and control of the various steps of perfusion/storage.
HPC‐1/syntaxin 1A gene knockout mice show abnormal behavior possibly related to a disruption in 5‐HTergic systems (2010)

HPC-1/syntaxin 1A (STX1A) is thought to regulate the exocytosis of synaptic vesicles in neurons. In recent human genetic studies, STX1A has been implicated in neuropsychological disorders. To examine whether STX1A gene ablation is responsible for abnormal neuropsychological profiles observed in human psychiatric patients, we analysed the behavioral phenotype of STX1A knockout mice. Abnormal behavior was observed in both homozygotes (STX1A(-/-)) and heterozygotes (STX1A(+/-)) in a social interaction test, a novel object exploring test and a latent inhibition (LI) test, but not in a pre-pulse inhibition test. Interestingly, attenuation of LI, which is closely related to human schizotypic symptoms, was restored by administration of the selective serotonin reuptake inhibitor, fluoxetine, but not by the dopamine reuptake inhibitor, GBR12935, or the noradrenalin reuptake inhibitor, desipramine. We also observed that LI attenuation was restored by DOI (a 5-HT(2A) receptor agonist), but not by 8-OH-DPAT (a 5-HT(1A) receptor agonist), mCPP (a 5-HT(2C) receptor agonist), SKF 38393 (a D(1) receptor agonist), quinpirole (a D(2)/D(3) receptor agonist) or haloperidol (a D(2)/D(3) receptor antagonist). Thus, attenuation of LI is mainly caused by disruption of 5-HT-ergic systems via 5-HT(2A) receptors. In addition, 5-HT release from hippocampal and hypothalamic slices was significantly reduced. Therefore, ablation of STX1A may cause disruption of 5-HT-ergic transmission and induce abnormal behavior.