gebhart/patrepeval huggingface dataset:
Removal of hypotaurine from porcine embryo culture medium does not impair development of in vitro‐fertilized or somatic cell nuclear transfer‐derived embryos at low oxygen tension (2020)

Hypotaurine (HT) is a routine component of porcine embryo culture medium, functioning as an antioxidant, but its requirement may be diminished as most embryo culture systems now use 5% O<sub>2</sub> instead of atmospheric (20%) O<sub>2</sub> . Our objective was to determine the effects of removing HT from the culture medium on porcine preimplantation embryo development. Embryos cultured in 20% O<sub>2</sub> without HT had decreased blastocyst development compared to culture with HT or in 5% O<sub>2</sub> with or without HT. Notably, differences in blastocyst development or total cell number were not detected between embryos cultured in 5% O<sub>2</sub> with or without HT. After culture in 5% O<sub>2</sub> without HT and embryo transfer, healthy fetuses were retrieved from two pregnancies on Day 42, confirming in vivo developmental competence. Transcript abundance of proapoptotic markers was decreased in embryos cultured without HT regardless of oxygen tension; however, assays for apoptosis did not demonstrate differences between groups. Additionally, no differences were observed in the development or apoptosis of somatic cell nuclear transfer-derived embryos cultured in 5% O<sub>2</sub> with or without HT. With decreased utility in 5% O<sub>2</sub> , removing HT from porcine embryo culture medium would also have economic advantages because it is undoubtedly the most expensive component.
Extended (180 V) voltage in 0.6 μm thin-layer-SOI A-BCD3 technology on 1 μm BOX for display, automotive and consumer applications (2003)

In this paper the extension to 180 V of a compact 0.6 /spl mu/m Silicon-on-Insulator BCD-technology on 1 /spl mu/m Buried Oxide is discussed. DMOS performance (n- and p-type) at 180 V has been simulated after calibration on 120 V devices and first experimental results are given. Also the feasibility of milli-Ohm power devices in three level power metal without Cu plating is demonstrated.
Data from Fecal Bacteria Act as Novel Biomarkers for Noninvasive Diagnosis of Colorectal Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Gut microbiota have been implicated in the development of colorectal cancer. We evaluated the utility of fecal bacterial marker candidates identified by our metagenome sequencing analysis for colorectal cancer diagnosis.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Subjects (total 439; 203 colorectal cancer and 236 healthy subjects) from two independent Asian cohorts were included. Probe-based duplex quantitative PCR (qPCR) assays were established for the quantification of bacterial marker candidates.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Candidates identified by metagenome sequencing, including &lt;i&gt;Fusobacterium nucleatum&lt;/i&gt; (&lt;i&gt;Fn&lt;/i&gt;), &lt;i&gt;Bacteroides clarus&lt;/i&gt; (&lt;i&gt;Bc&lt;/i&gt;), &lt;i&gt;Roseburia intestinalis&lt;/i&gt; (&lt;i&gt;Ri&lt;/i&gt;), &lt;i&gt;Clostridium hathewayi&lt;/i&gt; (&lt;i&gt;Ch&lt;/i&gt;), and one undefined species (labeled as &lt;i&gt;m7&lt;/i&gt;), were examined in fecal samples of 203 colorectal cancer patients and 236 healthy controls by duplex-qPCR. Strong positive correlations were demonstrated between the quantification of each candidate by our qPCR assays and metagenomics approach (&lt;i&gt;r&lt;/i&gt; = 0.801–0.934, all &lt;i&gt;P&lt;/i&gt; &lt; 0.0001). &lt;i&gt;Fn&lt;/i&gt; was significantly more abundant in colorectal cancer than controls (&lt;i&gt;P&lt;/i&gt; &lt; 0.0001), with AUROC of 0.868 (&lt;i&gt;P&lt;/i&gt; &lt; 0.0001). At the best cut-off value maximizing sum of sensitivity and specificity, &lt;i&gt;Fn&lt;/i&gt; discriminated colorectal cancer from controls with a sensitivity of 77.7%, and specificity of 79.5% in cohort I. A simple linear combination of four bacteria (&lt;i&gt;Fn&lt;/i&gt; + &lt;i&gt;Ch&lt;/i&gt; + &lt;i&gt;m7&lt;/i&gt;-&lt;i&gt;Bc&lt;/i&gt;) showed an improved diagnostic ability compared with &lt;i&gt;Fn&lt;/i&gt; alone (AUROC = 0.886, &lt;i&gt;P&lt;/i&gt; &lt; 0.0001) in cohort I. These findings were further confirmed in an independent cohort II. In particular, improved diagnostic performances of &lt;i&gt;Fn&lt;/i&gt; alone (sensitivity 92.8%, specificity 79.8%) and four bacteria (sensitivity 92.8%, specificity 81.5%) were achieved in combination with fecal immunochemical testing for the detection of colorectal cancer.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Stool-based colorectal cancer–associated bacteria can serve as novel noninvasive diagnostic biomarkers for colorectal cancer. &lt;i&gt;Clin Cancer Res; 23(8); 2061–70. ©2016 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Determining printer and scanner resolution dependency of text classification for digital image forensics (2010)

Forensic identification of the hardware used during printing and image scanning is a technology of value for security printing, inspection and even criminal investigations. The more familiar image forensics are concerned with determining the operations that have been performed on a digital image&#x2014;usually for identifying the camera model used to capture the image. When an image is both printed and scanned, however, the forensics task is more complicated, since the print-scan (PS) cycle introduces less specific effects on the images. In order to identify the printer used to produce and read an image, classification must be performed. In this paper, we use a multi-class Adaboost classifier to determine which of 6 printers, representing 3 inkjet and 2 laserjet models, was used to produce a later-scanned image. Our results, investigating 6 different English characters, show that classification accuracy continues to increase with scanning resolution up to 1200 pixels/inch. The results are character-dependent, suggesting that different characters may be used for different forensic purposes&#x2014;printer model, cartridge and individual printer identification as examples.
Syntheses and Structure−Activity Relationships of the Second-Generation Antitumor Taxoids:  Exceptional Activity against Drug-Resistant Cancer Cells (1996)

A series of new 3'-(2-methyl-1-propenyl) and 3'-(2-methylpropyl) taxoids with modifications at C-10 was synthesized by means of the beta-lactam synthon method using 10-modified 7-(triethylsilyl)-10-deacetylbaccatin III derivatives. The new taxoids thus synthesized show excellent cytotoxicity against human ovarian (A121), non-small-cell lung (A549), colon (HT-29), and breast (MCF-7) cancer cell lines. All but one of these new taxoids possess better activity than paclitaxel and docetaxel in the same assay, i.e., the IC50 values of almost all the taxoids are in the subnanomolar level. It is found that a variety of modifications at C-10 is tolerated for the activity against normal cancer cell lines, but the activity against a drug-resistant human breast cancer cell line expressing MDR phenotype (MCF7-R) is highly dependent on the structure of the C-10 modifier. A number of the new taxoids exhibit remarkable activity (IC50 = 2.1-9.1 nM) against MCF7-R. Among these, three new taxoids, SB-T-1213 (4a), SB-T-1214 (4b), and SB-T-1102 (5a), are found to be exceptionally potent, possessing 2 orders of magnitude better activity than paclitaxel and docetaxel. The observed exceptional activity of these taxoids may well be ascribed to an effective inhibition of P-glycoprotein binding by the modified C-10 moieties. The new taxoid SB-T-1213 (4a) shows an excellent activity (T/C = 0% at 12.4 and 7.7 mg/kg/dose, log10 cell kill = 2.3 and 2.0, respectively) against B16 melanoma in B6D2F1 mice via intravenous administration.
Resonances and CP violation in B s 0 and B ¯ s 0 → J / ψ K + K − $$ {\overline{B}}_s^0\to J/\psi {K}^{+}{K}^{-} $$ decays in the mass region above the ϕ(1020) (2017)

The decays of B 0 s and B 0 s mesons into the J/K + K -final state are studied in the K + K -mass region above the (1020) meson in order to determine the resonant substructure and measure the CP -violating phase, s , the decay width, s , and the width difference between light and heavy mass eigenstates, s . A decay-time dependent amplitude analysis is employed. The data sample corresponds to an integrated luminosity of 3 fb -1 produced in 7 and 8 TeV pp collisions at the LHC, collected by the LHCb experiment. The measurement determines s = 119 107 34 mrad. A combination with previous LHCb measurements using similar decays into the J/ + -and J/(1020) final states gives s = 1 37 mrad, consistent with the Standard Model prediction.
Thread Forming in Lightweight Material Joints Using Self-Tapping Screws (2016)

In this study, thread forming performance is evaluated under cyclic heating and cooling of tapped lightweight multimaterial joints in which steel self-tapping screws are used. Joint performance is assessed in terms of residual torque, pullout strength, load transfer capacity (LTC), and failure mode. Cyclic temperature fluctuates between 130 °C and −20 °C in a computer-controlled environmental chamber. Joint coupon materials are steel and Nylon polymeric material. Data analysis and discussion are provided. Analysis of experimental data provides a useful insight into design optimization of self-tapped joints.
Freeze that Sperm. (2006)

One of the side effects of cancer therapy—be it radiotherapy, chemotherapy, and/or surgery—is a potential detrimental hit to the reproductive system. This could be devastating psychologically to couples in which the male partner has been treated for an oncological disease. The gonads themselves are very susceptible to radiotherapy and chemotherapy, and some surgical procedures destroy or disable the function of the male ductal system, which might result in a lack of seminal emission and/or a ductal obstruction. It is well recognized that the cancer itself might have an impact on the reproductive system, and infertility sometimes might be the presenting complaint of someone with an oncological disease, depending on the tissue affected and the severity of the disease. Thus, when the aforementioned oncological treatments are given to these patients, their fertility status is further compromised. These gonadotoxic effects can be either temporary or permanent. If the former, it can sometimes take 1 to 2 years after the completion of treatment for spermatogenesis to recover. In a number of patients, again depending on the type and duration of therapy, azoospermia might be permanent. As such, it seems prudent that any man who is a potential future father be evaluated with a semen analysis if (1) he is diagnosed with a cancer, and (2) he is to undergo some form of therapy for this tumor.
Self-protecting semiconductor optical limiters (1988)

We present a detailed characterization of passive, picosecond optical-power-limiting devices using tightly focused beams in thick semiconductor samples. This study of limiting in ZnSe with 30-psec, 532-nm pulses shows that the resulting internal self-action (two-photon absorption plus free-carrier self-defocusing) protects the bulk material from optical damage. Simple scaling relations were determined from our results that link the limiting energy and the dynamic range to the focusing geometry and sample dimensions. These relations were used to design a monolithic optical limiter, optimized to have maximum dynamic range and minimum limiting energy. This device limits at an input energy of 10 nJ (300 W) and has a dynamic range greater than 10(4).
A unified instruction set programmable architecture for multi-standard advanced forward error correction (2008)

The continuously increasing number of communication standards to be supported in nomadic devices combined with the fast ramping design cost in deep submicron technologies claim for highly reusable and flexible programmable solutions. Software defined radio (SDR) aims at providing such solutions in radio baseband architectures. Great advances were recently booked in handset-targeted SDR, covering most of the baseband processing with satisfactory performance and energy efficiency. However, as it typically depicts a magnitude higher computation load, forward error correction (FEC) has been excluded from the scope of high throughput SDR solutions and let to dedicated hardware accelerators. The currently growing number of advanced FEC options claims however for flexibility there too. This paper presents the first application-specific instruction programmable architecture addressing in a unified way the emerging turbo- and LPDC coding requirements of 3GPP-LTE, IEEE802.11n, IEEE802.16(e) and DVB-S2/T2. The proposal shows a throughput from 0.07 to 1.25 Mbps/MHz with efficiencies round 0.32 nJ/bit/iter in turbo mode and round 0.085 nJ/bit/iter in LDPC mode. The area is lower than the cumulated area of dedicated turbo and LDPC solution.
Gene Coexpression Connectivity Predicts Gene Targets Underlying High Ionic-Liquid Tolerance in Yarrowia lipolytica (2022)

Microbial tolerance to organic solvents such as ionic liquids (ILs) is a robust phenotype beneficial for novel biotransformation. While most microbes become inhibited in 1% to 5% (vol/vol) IL (e.g., 1-ethyl-3-methylimidazolium acetate), we engineered a robust Yarrowia lipolytica strain (YlCW001) that tolerates a record high of 18% (vol/vol) IL via adaptive laboratory evolution. Yet, genotypes conferring high IL tolerance in YlCW001 remain to be discovered. In this study, we shed light on the underlying cellular processes that enable robust Y. lipolytica to thrive in inhibitory ILs. By using dynamic transcriptome sequencing (RNA-Seq) data, we introduced Gene Coexpression Connectivity (GeCCo) as a metric to discover genotypes conferring desirable phenotypes that might not be found by the conventional differential expression (DE) approaches. GeCCo selects genes based on their number of coexpressed genes in a subnetwork of upregulated genes by the target phenotype. We experimentally validated GeCCo by reverse engineering a high-IL-tolerance phenotype in wild-type Y. lipolytica. We found that gene targets selected by both DE and GeCCo exhibited the best statistical chance at increasing IL tolerance when individually overexpressed. Remarkably, the best combination of dual-overexpression genes was genes selected by GeCCo alone. This nonintuitive combination of genes, BRN1 and OYE2, is involved in guiding/regulating mitotic cell division, chromatin segregation/condensation, microtubule and cytoskeletal organization, and Golgi vesicle transport. <b>IMPORTANCE</b> Cellular robustness to cope with stressors is an important phenotype. Y. lipolytica is an industrial robust oleaginous yeast that has recently been discovered to tolerate record high concentrations of ILs, beneficial for novel biotransformation in organic solvents. However, genotypes that link to IL tolerance in Y. lipolytica are largely unknown. Due to the complex IL-tolerant phenotype, conventional gene discovery and validation based on differential gene expression approaches are time-consuming due to a large search space and might encounter a high false-discovery rate. Here, using the developed Gene Coexpression Connectivity (GeCCo) method, we identified and validated a subset of most promising gene targets conferring the IL-tolerant phenotypes and shed light on their potential mechanisms. We anticipate GeCCo being a useful method to discover the genotype-to-phenotype link.
In SituBiosynthesis of a Metal Nanoparticle Encapsulated in Alginate Gel for Imageable Drug-Delivery System (2021)

Development of drug-delivery systems that allow simultaneous <i>in vivo</i> imaging has gained much interest. We report a novel strategy to encapsulate metal nanoparticles (NPs) within alginate gel for <i>in vivo</i> imaging. The cell lysate of recombinant <i>Escherichia coli</i> strain, expressing <i>Arabidopsis thaliana</i> phytochelatin synthase and <i>Pseudomonas putida</i> metallothionein genes, was encapsulated within the alginate gel. Incubation of alginate gel with metal ion precursors followed by UV irradiation resulted in the synthesis of high concentrations of metal NPs, such as Au, Ag, CdSe, and EuSe NPs, within the gel. The alginate gel with metal NPs was used as a drug-delivery system by further co-encapsulating doxorubicin and rifampicin, the release of which was made to be pH-dependent. This system can be conveniently and safely used for <i>in vitro</i> and <i>in vivo</i> bioimaging, enabled by the metal NPs formed within the gel matrix without using toxic reducing reagents or surfactants.
On Closed Loop Transmit Diversity for HSDPA - using an Orthogonality Matrix for System Level Evaluations (2005)

The paper studies closed loop (CL) transmit diversity in combination with high speed downlink packet access (HSDPA). A potential problem with this combination is the reduced interference predictability which affects scheduling and link adaptation. To study this, the orthogonality factor (OF), which is used to model the intra-cell interference for single antenna transmission and reception, is augmented by an orthogonality matrix (OM), which is used for dynamic system level evaluations. The results indicate that the reduced predictability may decrease system performance in terms of cell throughput by approximately one third for a system employing multiuser diversity in a dispersive environment. However, by scheduling multiple users in a certain proposed way, interference fluctuations may be reduced, and results show that the performance may be improved. A simple spatial channel model is used so that the impact of fading correlation is considered as well.
Development and Practical Application of High-efficiency Fire Control System for the Clean Room (2006)

With the upsizing of wafers and substrates, the scale of clean room factories in the semiconductor/LCD industry is also expanding. Capital investment is as high as Y500 billion (US$5 billion), boosting the asset value significantly. To secure a stable supply, suspension of production due to fire must never happen. The INERGEN gas fire control equipment [1], which sprays gas over the entire building to reduce the oxygen concentration to less than 15%, has been developed and installed at some universities and corporations. It is not harmful to people because there is carbon dioxide (CO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> ) in the gas to prevent breathing difficulties [2]. However, since the plant cost is enormous, it is suitable for relatively small facilities only. An efficient and low-cost system adopting Ar-CO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> gas has been newly developed for quickly extinguishing fires in large factories.
Tel-eVax: a genetic vaccine targeting telomerase for treatment of canine lymphoma (2018)

Tel-eVax in combination with CHOP is safe and immunogenic in lymphoma canine patients. These data confirm the therapeutic efficacy of dTERT vaccine and hold promise for the treatment of dogs affected by other cancer types. More importantly, our findings may translate to human clinical trials and represent new strategies for cancer treatment.
A flexible IPv6 mobility management architecture for SDN‐based 5G mobile networks (2019)

Abstract With the advent of increasingly diverse services, applications, and use cases, the 5G mobility environment is expected to be highly heterogeneous. The distributed mobility management (DMM) is emerging as a promising approach for 5G, which provides decentralized handover and traffic management at the edge of the network. However, in order to meet the disparate mobility needs, the DMM process requires flexible design considerations. This paper presents a novel mobile node (MN) centered, software‐defined networking (SDN)–based flexible mobility management architecture, named adaptive multimode mobility management (A3M), which can adaptively operate in multiple modes. The proposed A3M architecture incorporates a novel handover mode selection phase among the traditional handover phases during which a suitable mode of handover operation is evaluated. This makes the A3M handover process adaptable to the varying mobility requirements of the MN and enables it to provide differentiated handover management for MNs with different mobility profiles. The performance analysis of A3M shows that it offers optimal handover performance in terms of primary handover performance metrics such as session disruption delay, packet losses, and signaling costs, compared to the popular network‐based DMM approaches.
Novel screening metric for the identification of at-risk peripheral artery disease patients using administrative claims data (2015)

Despite high morbidity and mortality associated with peripheral artery disease (PAD), it remains under-diagnosed and under-treated. The objective of this study was to develop a screening metric to identify undiagnosed patients at high risk of developing PAD using administrative data. Commercial claims data from 2010 to 2012 were utilized to develop and internally validate a PAD screening metric. Medicare data were used for external validation. The study population included adults, aged 30 years or older, with new cases of PAD identified using the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) diagnosis/procedure codes or the Healthcare Common Procedure Coding System (HCPCS) codes. Multivariate logistic regression was conducted to determine PAD risk factors used in the development of the screening metric for the identification of at-risk PAD patients. The cumulative incidence of PAD was 6.6%. Sex, age, congestive heart failure, hypertension, chronic renal insufficiency, stroke, diabetes, acute myocardial infarction, transient ischemic attack, hyperlipidemia, and angina were significant risk factors for PAD. A cut-off score of ⩾20 yielded sensitivity, specificity, positive predictive value, negative predictive value, and c-statistics of 83.5%, 60.0%, 12.8%, 98.1%, and 0.78, respectively. By identifying patients at high risk for developing PAD using only administrative data, the use of the current pre-screening metric could reduce the number of diagnostic tests, while still capturing those patients with undiagnosed PAD.
Syntheses and characterization of functionalized polynorbornene dicarboximides for flexible substrates (2012)

In this study, we synthesized polynorbornene (PNB) dicarboximides substituted by monochlorophenyl group (PMCPhNDI) and dichlorophenyl group (PDCPhNDI) via ring‐opening polymerization using a ruthenium catalyst and investigated their thermal, mechanical, and optical properties. We also discussed the performance and application of the functionalized PNB dicarboximide films as flexible substrates for organic light‐emitting devices (OLEDs). The polymer films exhibited good optical transparency with an average transmittance of around 97% in the visible light region and good thermal stability with a 5% degradation temperature of &gt;440°C. The polymers were applied for flexible displays, which were coated on indium tin oxide (ITO) thin films using a radio‐frequency planar magnetron sputtering system with changing the deposition substrate temperatures. A flexible OLED that was fabricated on the ITO‐grown polymer substrates exhibited a performance as comparable to the corresponding ITO‐grown glass substrates. Copyright © 2012 John Wiley &amp; Sons, Ltd.