gebhart/patrepeval huggingface dataset:
Evaluation of Scapholunate Injury and Repair with Dynamic (4D) CT: A Preliminary Report of Two Cases (2023)

<b>Background</b> In predynamic or dynamic scapholunate (SL) instability, standard diagnostic imaging may not identify SL interosseous ligament (SLIL) injury, leading to delayed detection and intervention. This study describes the use of four-dimensional computed tomography (4DCT) in identifying early SLIL injury and following injured wrists to 1-year postoperatively. <b>Description of Technique</b> 4DCT acquires a series of three-dimensional volume data with high temporal resolution (66 ms). 4DCT-derived arthrokinematic data can be used as biomarkers of ligament integrity. <b>Patients and Methods</b> This study presents the use of 4DCT in a two-participant case series to assess changes in arthrokinematics following unilateral SLIL injury preoperatively and 1-year postoperatively. Patients were treated with volar ligament repair with volar capsulodesis and arthroscopic dorsal capsulodesis. Arthrokinematics were compared between uninjured, preoperative injured, and postoperative injured (repaired) wrists. <b>Results</b> 4DCT detected changes in interosseous distances during flexion-extension and radioulnar deviation. Generally, radioscaphoid joint distances were greatest in the uninjured wrist during flexion-extension and radioulnar deviation, and SL interval distances were smallest in the uninjured wrist during flexion-extension and radioulnar deviation. <b>Conclusion</b> 4DCT provides insight into carpal arthrokinematics during motion. Distances between the radioscaphoid joint and SL interval can be displayed as proximity maps or as simplified descriptive statistics to facilitate comparisons between wrists and time points. These data offer insight into areas of concern for decreased interosseous distance and increased intercarpal diastasis. This method may allow surgeons to assess whether (1) injury can be visualized during motion, (2) surgery repaired the injury, and (3) surgery restored normal carpal motion. <b>Level of Evidence</b> Level IV, Case series.
Automatic modulation classification using zero crossing (1990)

A modulation recogniser that automatically reports modulation types of constant-envelope modulated signals is developed using zero-crossing techniques. The zero-crossing sampler, as a signal conditioner, has the advantage of providing accurate phase transition information over a wide dynamic frequency range. Signal parameters such as zero-crossing variance, carrier-to-noise ratio (CNR) and carrier frequency are estimated. Phase difference and zero-crossing interval histograms play the role of features for modulation recognition. The classifier performance is given in the form of a confusion matrix. The simulation results obtained demonstrate that a reasonable average probability of correct classification is achievable for CNR ≥ 15 dB.
Enhancement of Seebeck Coefficient in Bi$_{0.5}$Sb$_{1.5}$Te$_{3}$ with High-Density Tellurium Nanoinclusions (2011)

Bi0.5Sb1.5Te3 films with homogeneously dispersed ∼15 nm Te nanoparticles were prepared by the alternate deposition of Bi0.5Sb1.5Te3 layers and Te nanoparticles. As the amount of Te nanoinclusions increased to 15 vol %, the Seebeck coefficient increased from 169 to 248 µV/K. The authors concluded that the high-density Te nanoinclusions result in a carrier energy filtering effect in Bi0.5Sb1.5Te3. Consequently, the thermoelectric power factor was enhanced by 30% despite a reduction in electrical conductivity. The improvement of the power factor implies the enhancement of the thermoelectric figure of merit ZT, providing the possibility of further ZT improvement by embedding Te nanoinclusions in Bi0.5Sb1.5Te3 bulk materials.
Accumulation of the Proteolytic Marker Peptide Ubiquitin in the Trophoblast of Mammalian Blastocysts (2001)

Ubiquitination is a universal protein degradation pathway in which the molecules of 8.5-kDa proteolytic peptide ubiquitin are covalently attached to the epsilon-amino group of the substrate's lysine residues. Little is known about the importance of this highly conserved mechanism for protein recycling in mammalian gametogenesis and fertilization. The data obtained by the students and faculty of the international training course Window to the Zygote 2000 demonstrate the accumulation of ubiquitin-cross-reactive structures in the trophoblast, but not in the inner cell mass of the expanding bovine and mouse blastocysts. This observation suggests that a major burst of ubiquitin-dependent proteolysis occurs in the trophoblast of mammalian peri-implantation embryos. This event may be important for the success of blastocyst hatching, differentiation of embryonic stem cells into soma and germ line, and/or implantation in both naturally conceived and reconstructed mammalian embryos.
Vortical and thermal interfacial layers in wall-bounded turbulent flows under transcritical conditions (2019)

Evidence of the presence of vortical and thermal interfacial layers in transcritical turbulent channel flow is presented. These interfaces are tied to the uniform momentum zones. In an analogous manner, uniform thermal zones are defined and characterized in these complex flows.
C-V characterization of MOS capacitors on high resistivity silicon substrate (2004)

This work reports on an investigation of capacitance-voltage (C-V) measurement of metal-oxide-semiconductor (MOS) capacitors on high resistivity silicon (HRS) used as substrate for radio-frequency (RF) integrated circuits. C-V MOS-capacitor characteristics differ considerably from those on low-resistivity silicon (LRS) due to potential drop in the substrate and large Debye length. Modeling of the substrate by a simple network of parallel resistors and capacitors is found to be insufficient at high frequencies in HRS. Medici simulations confirm the conclusions.
Total androgen-receptor gene expression inhibitor therapy (TARGET): A phase II trial of neoadjuvant SAHA (S) followed prostatectomy for patients (pts) with high-risk prostate cancer (pc). (2010)

e15133 Background: Androgen depletion (ADT) with a gonadotropin releasing hormone (GnRH) analog alone or with an anti- androgen does not ensure complete inhibition of signaling through the androgen receptor (AR). ADT with S (SAHA, suberoylanilide hydroxamic acid), an HDAC, can inhibit HSP90 resulting in loss of HSP90 binding to and degradation of client protein. HDAC inhibitors may reduce AR expression and sensitize pc cells to hormone antagonists. This phase II trial explores whether neoadjuvant ADT with S, can affect signaling through AR, increase the rate of pathologic response (p0), and determine the molecular pathways of response/resistance in pre/posttreatment blood and tissue, respectively, along with testosterone (T), its precursors, and AR target genes. Methods: Pts with newly diagnosed pc of any Gleason score were enrolled as long as they had an abnormal PSA and 1 of 3 or more cores containing ≥ 30% pc. Sixteen of 19 pts were accrued; 11 at MSKCC are reported. Each received S 400mg po daily for 6-8 weeks, bicalutamide 50mg for 4 weeks, and monthly GnRH followed by radical, laparoscopic or robotic prostatectomy. Results: Pretreatment median age was 64yrs, clinical stage T1c 6 pts [T1c-T3], Gleason score 3+4 [7-9], T 343ng/dl [140-521], and PSA 6.36ng/ml [3.87-27.64]. S was well-tolerated; 7 of 11 pts had grade 1 fatigue; 5 had grade 1 diarrhea. Post-surgical median pathologic stage was T2b (5 pts) [1-pT2+; 1-T2c; 2-T3a; 1-T3b; 1-T3bN1]. No pt achieved p0 but 10 of 11 pts achieved a PSA of <0.05 post T recovery with median durability of 87 days [17-379]. Post surgical median time to T recovery in 7 completed pts was 65.1 days [48-167]. Conclusions: The use of neoadjuvant S and a GnRH agonist as proof of concept did not result in a p0 in any of the 11 patients treated to date, however 10 pts had post surgical PSA nadirs of ≤ 0.05 which have been durable. Six additional pts are under treatment at this time. The impact on molecular and biologic markers within postsurgical tissue samples is ongoing. Supported by The Prostate Cancer Foundation/Department of Defense Prostate Cancer Clinical Trials Consortium, and NCI P50-CA92629 SPORE in Prostate Cancer. No significant financial relationships to disclose.
DYNAMICS OF COGNITION (2014)

A summary is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Common and species-specific molecular signatures, networks, and regulators of influenza virus infection in mice, ferrets, and humans (2022)

Molecular responses to influenza A virus (IAV) infections vary between mammalian species. To identify conserved and species-specific molecular responses, we perform a comparative study of transcriptomic data derived from blood cells, primary epithelial cells, and lung tissues collected from IAV-infected humans, ferrets, and mice. The molecular responses in the human host have unique functions such as antigen processing that are not observed in mice or ferrets. Highly conserved gene coexpression modules across the three species are enriched for IAV infection-induced pathways including cell cycle and interferon (IFN) signaling. <i>TDRD7</i> is predicted as an IFN-inducible host factor that is up-regulated upon IAV infection in the three species. <i>TDRD7</i> is required for antiviral IFN response, potentially modulating IFN signaling via the JAK/STAT/IRF9 pathway. Identification of the common and species-specific molecular signatures, networks, and regulators of IAV infection provides insights into host-defense mechanisms and will facilitate the development of novel therapeutic interventions against IAV infection.
On the Power of Feature Analyzer for Signature Verification (2005)

This paper is concerned with verification of signatures using feature analysis and non linear classifier. Signatures are collected and scanned to obtain input image. Preprocessing involves removal of noise and making the input image size invariant. Feature analyzer can reduce the large domain of feature space and extract invariable information. Because of non linearity present in the input, a non linear classifier is used. Instead of using feed forward neural network, multiple feed forward neural networks are used which are trained in the form of ensemble. Using such ensemble makes the system more general than a regular single neural network based system. Resilient back propagation algorithm has been used for each neural network training to achieve faster recognition. Significant amount of training and testing has been performed using 10 fold cross validation and resultant impressive recognition accuracy (More than 90%) proves the effectiveness of the system.
Abstract SY01-02: Mapping the landscape of conditional vulnerabilities in non-small cell lung cancer (2011)

Abstract Recognition that cancer is a diverse disease, driven by discordant patient-specific aberrations of cell function, has launched intense efforts to identify drugs matched to the needs of individual patients. However, selection of appropriate treatment is dramatically limited by the paucity of available drugs and by the difficulty of linking treatment options to the appropriate patients. We are employing an extensive panel of non-small cell lung cancer-derived cell lines and clinically pathologically annotated tumor samples to model the diversity of molecular etiologies driving lung cancer initiation and progression. By using quantitative measures of molecular correlates together with concordant responses to whole-genome genetic perturbations and 200,000 small molecule perturbations, we have parsed this heterogeneous panel into a limited number of clades defined by shared liabilities coupled to robust molecular biomarkers. Many of these liabilities represent new intervention targets together with chemical matter that intersects those targets. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr SY01-02. doi:10.1158/1538-7445.AM2011-SY01-02
Thermal lens effect and fluorescence of motor oil investigated by holographic method (2017)

This paper presents studies of the thermal lens effect in the volume of motor oil by holographic methods using excitation of 447[Formula: see text]nm laser wavelength. The possibility of using a hologram of initial object, as a diffractive element, for obtaining the spectral dependence of the fluorescence of the oil product was shown.
CCD camera imaging for the chemiluminescent detection of enzymes using new ultrasensitive reagents (1994)

We have designed and constructed an inexpensive imaging system based on charge-coupled device (CCD) technology and utilized it to demonstrate the sensitivity and rapid detection possible with Lumigen chemiluminescent reagents. We also report the development of two new chemiluminescent reagents, Lumi-Phos Plus and Lumigen PS. Lumi-Phos Plus is an enhanced formulation for the rapid detection of alkaline phosphatase on membranes and in solution. It provides excellent images in blotting applications with exposures of under a minute. Lumigen PS represents a new generation of peroxidase detection reagents. The wide dynamic range with excellent linearity, higher signal and lower background than other chemiluminescent reagents make Lumigen PS of unsurpassed value in enzyme-linked immunoassays and nucleic acid probe assays using HRP conjugates.
Ciprofloxacin is an inhibitor of the Mcm2-7 replicative helicase (2013)

Most currently available small molecule inhibitors of DNA replication lack enzymatic specificity, resulting in deleterious side effects during use in cancer chemotherapy and limited experimental usefulness as mechanistic tools to study DNA replication. Towards development of targeted replication inhibitors, we have focused on Mcm2-7 (minichromosome maintenance protein 2-7), a highly conserved helicase and key regulatory component of eukaryotic DNA replication. Unexpectedly we found that the fluoroquinolone antibiotic ciprofloxacin preferentially inhibits Mcm2-7. Ciprofloxacin blocks the DNA helicase activity of Mcm2-7 at concentrations that have little effect on other tested helicases and prevents the proliferation of both yeast and human cells at concentrations similar to those that inhibit DNA unwinding. Moreover, a previously characterized mcm mutant (mcm4chaos3) exhibits increased ciprofloxacin resistance. To identify more potent Mcm2-7 inhibitors, we screened molecules that are structurally related to ciprofloxacin and identified several that compromise the Mcm2-7 helicase activity at lower concentrations. Our results indicate that ciprofloxacin targets Mcm2-7 in vitro, and support the feasibility of developing specific quinolone-based inhibitors of Mcm2-7 for therapeutic and experimental applications.
Intergration of seismic and geomechanical methods for deepwater reservoir prediction and drilling design (1998)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1998Intergration of seismic and geomechanical methods for deepwater reservoir prediction and drilling designAuthors: Stan LeeJesse ShawDavid McadowStan LeeMobil Technology Company, Jesse ShawMobil Technology Company, and David McadowMobil E&P UShttps://doi.org/10.1190/1.1820070 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1820070FiguresReferencesRelatedDetails SEG Technical Program Expanded Abstracts 1998ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1998 Pages: 2092 publication data© 1998 Copyright © 1998 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 06 Jan 2005 CITATION INFORMATION Stan Lee, Jesse Shaw, and David Mcadow, (1998), "Intergration of seismic and geomechanical methods for deepwater reservoir prediction and drilling design," SEG Technical Program Expanded Abstracts : 1068-1071. https://doi.org/10.1190/1.1820070 Plain-Language Summary PDF DownloadLoading ...
Heuristic for Edge-enabled Network Slicing Optimization using the “Power of Two Choices” (2020)

We propose an online heuristic algorithm for the problem of network slice placement optimization. The solution is adapted to support placement on large scale networks and integrates Edge-specific and URLLC constraints. We rely on an approach called the "Power of Two Choices" to build the heuristic. The evaluation results show the good performance of the heuristic that solves the problem in few seconds under a large scale scenario. The heuristic also improves the acceptance ratio of network slice placement requests when compared against a deterministic online Integer Linear Programming (ILP) solution.
Quality of laboratory biomarker monitoring during treatment with lithium in patients with bipolar disorder (2023)

In a Swedish community sample, lithium and creatinine monitoring was inconsistent with guideline recommendations that call for measurement of annual biomarker levels.
Enabling Efficient RDMA-based Synchronous Mirroring of Persistent Memory Transactions (2018)

Synchronous Mirroring (SM) is a standard approach to building highly-available and fault-tolerant enterprise storage systems. SM ensures strong data consistency by maintaining multiple exact data replicas and synchronously propagating every update to all of them. Such strong consistency provides fault tolerance guarantees and a simple programming model coveted by enterprise system designers. For current storage devices, SM comes at modest performance overheads. This is because performing both local and remote updates simultaneously is only marginally slower than performing just local updates, due to the relatively slow performance of accesses to storage in today's systems. However, emerging persistent memory and ultra-low-latency network technologies necessitate a careful re-evaluation of the existing SM techniques, as these technologies present fundamentally different latency characteristics compared than their traditional counterparts. In addition to that, existing low-latency network technologies, such as Remote Direct Memory Access (RDMA), provide limited ordering guarantees and do not provide durability guarantees necessary for SM. To evaluate the performance implications of RDMA-based SM, we develop a rigorous testing framework that is based on emulated persistent memory. Our testing framework makes use of two different tools: (i) a configurable microbenchmark and (ii) a modified version of the WHISPER benchmark suite, which comprises a set of common cloud applications. Using this framework, we find that recently proposed RDMA primitives, such as remote commit, provide correctness guarantees, but do not take full advantage of the asynchronous nature of RDMA hardware. To this end, we propose new primitives enabling efficient and correct SM over RDMA, and use these primitives to develop two new techniques delivering high-performance SM of persistent memories.
Chip-Last HDFO (High-Density Fan-Out) Interposer-PoP (2021)

Interposer Package-on-Package (PoP) technology was developed and has been in very high-volume production over the last several years for high-end mobile application processors (APs). This is due to its advantages of good package design flexibility, controllable package warpage at room temperature (25°C) and high temperature (260°C), reduced assembly manufacturing cycle time and chip-last assembly manufacturing availability. To date, the laminate-substrate based interposer-PoP has been employed for high-end mobile APs with very high-volume production. Recently, this interposer-PoP design has faced some technical limitations including the need to reduce: top and bottom routing layer thickness, copper (Cu) trace line/space and via size for next generation mobile APs. These reductions may require ultra-thin package z-height and high-bandwidth bottom and top routing layers. To address these challenges, a new interposer-PoP with High-Density Fan-Out (HDFO) redistribution layer (RDL) routing layer has been designed and demonstrated. It is part of an initiative to achieve an ultra-thin package z-height, interposer-PoP structure with high bandwidth and improved signal integrity/power integrity (SI/PI) routing layer using a chip-last assembly manufacturing process flow. This paper will discuss package-level characterizations on the interposer-PoP with HDFO RDL routing layer as well as package z-height evaluation, temperature-dependent package warpage measurements and package-level reliability tests conducted in accordance with JEDEC.
Chemical Organization of the Cell Wall Polysaccharide Core of Malassezia restricta (2014)

Malassezia species are ubiquitous residents of human skin and are associated with several diseases such as seborrheic dermatitis, tinea versicolor, folliculitis, atopic dermatitis, and scalp conditions such as dandruff. Host-Malassezia interactions and mechanisms to evade local immune responses remain largely unknown. Malassezia restricta is one of the most predominant yeasts of the healthy human skin, its cell wall has been investigated in this paper. Polysaccharides in the M. restricta cell wall are almost exclusively alkali-insoluble, showing that they play an essential role in the organization and rigidity of the M. restricta cell wall. Fractionation of cell wall polymers and carbohydrate analyses showed that the polysaccharide core of the cell wall of M. restricta contained an average of 5% chitin, 20% chitosan, 5% β-(1,3)-glucan, and 70% β-(1,6)-glucan. In contrast to other yeasts, chitin and chitosan are relatively abundant, and β-(1,3)-glucans constitute a minor cell wall component. The most abundant polymer is β-(1,6)-glucans, which are large molecules composed of a linear β-(1,6)-glucan chains with β-(1,3)-glucosyl side chain with an average of 1 branch point every 3.8 glucose unit. Both β-glucans are cross-linked, forming a huge alkali-insoluble complex with chitin and chitosan polymers. Data presented here show that M. restricta has a polysaccharide organization very different of all fungal species analyzed to date.
Effects of Electron Donor Additives on Copolymerization of Styrene with Maleic Anhydride (1969)

スチレン(S)-無水マレイン酸(M)共重合系に供与体(アントラセン(A),ナフタリン(N),シクロヘキセン(C),ジヒドロフラン(D)を添加したときの影響を考察した。ナフタリン添加では共重合速度の加速現象が認められる。重合系は錯体を単位とした,いわば,Complex-merの単独重合とみなすことができ,錯体濃度[C]とRpの間には次の関係がある。Rp=k1[C]1.35(inCCl4);Rp=k2[C]1.01(inCH3COCH3)著者らは先にSM系で顕著な単量体(M)への連鎖移動を観測しているが,この供与体添加系でも同様の事実を認めた。この場合,連鎖移動は錯体単位で生起すると考えた方がよく,錯体への連鎖移動定数Ccは,1.93×10-2(inCC14)2.60×10-2(inTHF)となる。したがって,コモノマー添加時には2種錯体間の共重合とみなすことができ,見掛けの反応性比を次のように決定した。
Impact of preoperative calculation of nephron volume loss on future of partial nephrectomy techniques; planning a strategic roadmap for improving functional preservation and securing oncological safety (2017)

Preoperatively calculated RAIV significantly correlates with the amount of decline in PRF during long-term follow-up. The RAIV could lead our research to the level of prediction of the amount of PRF decline after PN and thus would be appropriate for assessing the technical advantages of emerging techniques.