gebhart/patrepeval huggingface dataset:
Canadian Consensus Meeting on cyclosporine monitoring: report of the consensus panel (1990)

Journal Article Canadian Consensus Meeting on cyclosporine monitoring: report of the consensus panel Get access L M Shaw, L M Shaw Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia 19104 Search for other works by this author on: Oxford Academic Google Scholar R W Yatscoff, R W Yatscoff Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia 19104 Search for other works by this author on: Oxford Academic Google Scholar L D Bowers, L D Bowers Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia 19104 Search for other works by this author on: Oxford Academic Google Scholar D J Freeman, D J Freeman Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia 19104 Search for other works by this author on: Oxford Academic Google Scholar J R Jeffery, J R Jeffery Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia 19104 Search for other works by this author on: Oxford Academic Google Scholar P A Keown, P A Keown Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia 19104 Search for other works by this author on: Oxford Academic Google Scholar I J McGilveray, I J McGilveray Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia 19104 Search for other works by this author on: Oxford Academic Google Scholar T G Rosano, T G Rosano Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia 19104 Search for other works by this author on: Oxford Academic Google Scholar P Y Wong P Y Wong Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia 19104 Search for other works by this author on: Oxford Academic Google Scholar Clinical Chemistry, Volume 36, Issue 10, 1 October 1990, Pages 1841–1846, https://doi.org/10.1093/clinchem/36.10.1841 Published: 01 October 1990
Towards high affinity carbohydrate-binding proteins: Directed evolution of murine galectin-3 (2002)

Towards a better understanding of the molecular basis of affinity, a directed evolution of murine galectin-3 (G3) was initiated to produce mutants with improved affinity for lactose and N-acetyllactosamine relative to the wild-type protein. A series of N-terminal truncations were developed to facilitate incorporation of the 35 kDa protein into a phage-display construct. Analysis of the various assemblies revealed that all such deletions produced protein unsuitable for use in directed evolution studies. Following fusion of the full-length galectin to p3 of filamentous phage, three libraries were constructed and biopanned for increased affinity for lactose. The first two libraries, of 1 × 10 5 and 1 × 10 6 members, respectively, were assembled through a combination of error-prone PCR and DNA shuffling. A third library was constructed using a modified staggered extension protocol (StEP), but contained only 10 members. Mutants were also engineered site-specifically to test the role of key residues in or near the binding pocket. Analysis of the mutants by ITC identified one mutation (R158G) that produces a twofold increase in affinity for lactose and another that results in a sixfold increase in affinity for N-acetyllactosamine. Solid-phase binding analysis of phage for nonexpressing proteins indicated that two other mutants demonstrated increased binding to beta-methyllactose relative to the wild-type protein. Together these studies validate the evolutionary approach and set the stage for the development of novel carbohydrate-binding proteins.Key words: phage display, directed evolution, galectin, thermodynamics, carbohydrates.
Unexpected heterogeneity of PML/RAR alpha fused mRNA detected by nested polymerase chain reaction in acute promyelocytic leukemia. (1993)

We have analyzed ten APL patients using reverse transcription polymerase chain reaction (RT-PCR) technique to detect PML/RAR alpha fused mRNA. All patients in this study had PML/RAR alpha fused mRNA (three cases of the short type and seven cases of the long type), although the chromosomal translocation t(15;17) was not detected in one patient. After ethidium bromide staining, two-thirds of the short type and all cases of the long type were found to have multiple PCR products (192 and 93 base pair (bp) bands in the short type and 666, 522, 263, and 164 bp in the long type). A total of six distinct fused mRNAs were sequenced (P1R1, P1R2, P3R1, P2R1, and P2R2). Southern hybridization analysis showed only one rearranged band in each of the patients. These results suggest that the longest mRNAs in each type are the authentic fused mRNAs and the other smaller mRNAs are generated through splicing events. In RAR alpha, a novel fusion point (R2) was identified within the fourth exon. This uncommon splicing may be caused by the instability of the splicing mechanism of the rearranged PML/RAR alpha gene. Among the ten APL patients, no correlation was observed between the type of fused mRNA and the clinical characteristics examined.
Supplemental Dataset 3 from Detecting the Presence and Progression of Premalignant Lung Lesions via Airway Gene Expression (2023)

&lt;p&gt;GSEA results detailing lung cancer associated dataset enrichment among genes differentially expressed in the airway field associated with PMLs&lt;/p&gt;
INNOVACIÓN METODOLÓGICA APLICADA A LA ENSEÑANZA DE SISTEMAS ELÉCTRICOS DE POTENCIA (2004)

En este trabajo se presenta la implementacin de un sitio WEB de apoyo a la docencia en la asignatura de Sistemas Elctricos de Potencia (SEP) para las carreras de
Impact of new transistor scaling methods on SOI SRAM cell stability (2006)

The size of the embedded SRAM is steadily increasing in high-end microprocessors like Athlon64/spl trade/ and Opteron/spl trade/. So the demand for small cell footprints and improved stability has become more challenging. We describe how AMD has recognized and addressed the competing aspects of technology scaling and improved stability in the 90nm technology.
Patterning fidelity on low-energy multiple-electron-beam direct write lithography (2008)

The Multiple E-beam Direct Write (MEBDW) technology has been considered a promising solution for the next generation lithography to delineate 32-nm half-pitch and beyond. A low-energy, say 5 keV, e-beam direct writing system has advantages in lower exposure dosage, less heating effect on resist, and less damage to devices underneath, comparing with a high energy one, such as 50 keV or 100 keV. However, the low-energy electron-beam is easily blurred due to forward scattering in the substrate due to its shallow penetration and hence loses resolution. In this paper, variables affecting patterning fidelity of a raster-scan MEBDW system are investigated. In order to realize a MEBDW system with acceptable throughput, a relatively large beam size is chosen for sufficient beam current to sustain throughput while maintaining enough resolution. The imaging resolution loss and the proximity effect, due to beam blurring through the resist, have been observed. The in-house software <b>MOSES</b>, incorporating the Monte Carlo simulation and the Double Gaussian model was used to evaluate 1-D and 2-D pattern fidelity with various exposure conditions. The line width roughness, which represents 1-D fidelity, was evaluated on 32-nm dense lines. Pattern fidelity of 2-D features such as the zigzag poly line and dense metal patterns was also examined. The impact to LWR of using the edge dithering method, instead of dosage modulation, to control the line width accuracy beyond the pixel size was studied.
Histamine receptor 1 is expressed in leukaemic cells and affects differentiation sensitivity (2020)

Despite the success of immunotherapy in several haematological neoplasms, the effectiveness in acute myeloid leukaemia (AML) is still controversial, partially due to the lack of knowledge regarding immune-related processes in this disease and similar neoplasias. In this study, we analysed the role and expression of histamine receptor 1 (HRH1) in haematological malignancies. Although the histamine receptor type 1 was widely expressed in healthy and malignant haematopoiesis, especially along the myeloid lineage, HRH1 lacked a relevant role in survival/proliferation and chemoresistance of AML cells, as analysed by HRH1 knockdown (KD) and pharmacological modulation. However, HRH1-mediated signalling was critical for the activation of the differentiation process induced by several agents including all-trans retinoic acid, establishing a role for HRH1 in myeloid differentiation. Pharmacological activation of Erk was able to partially restore differentiation capacity in HRH1 KD AML cells, suggesting that HRH1 signalling acts upstream MAPK-Erk pathway. As an indirect consequence of our results, treatment-related histamine release is not expected to confer a proliferative advantage in leukaemic cells.
Bioassay-Guided Isolation, Identification, and Quantification of the Estrogen-Like Constituent from PC SPES (2006)

The herbal mixture PC SPES, a dietary supplement for patients with prostate cancer, has been proved to have estrogenic activity in clinical trials. To determine the active components in PC SPES for estrogenic activity, a bioassay-guided fractionation of PC SPES using a functional estrogen receptor (ER) assay led to the isolation and identification of the most active constituent, ethinyl estrodiol, together with two flavonones, neobaicalein and tenaxin I. The isolation, identification and quantification of ethinyl estrodiol are discussed.
Top-Down Approach Making Anisotropic Cellulose Aerogels as Universal Substrates for Multifunctionalization (2020)

Highly porous, strong aerogels with anisotropic structural properties are of great interest for multifunctional materials for applications including insulators in buildings, filters for oil cleanup, electrical storage devices, <i>etc</i>. Contemporary aerogels are mostly extracted from fossil resources and synthesized from bottom-up techniques, often requiring additional strategies to obtain high anisotropy. In this work, a universal approach to prepare porous, strong, anisotropic aerogels is presented through exploiting the natural hierarchical and anisotropic structure of wood. The preparation comprises nanoscale removal of lignin, followed by dissolution-regeneration of nanofibers, leading to enhanced cell wall porosity with nanofibrillated networks occupying the pore space in the cellular wood structure. The aerogels retain structural anisotropy of natural wood, exhibit specific surface areas up to 247 m<sup>2</sup>/g, and show high compression strength at 95% porosity. This is a record specific area value for wood aerogels/foams and even higher than most cellulose-based aerogels for its assigned strength. The aerogel can serve as a platform for multifunctional composites including scaffolds for catalysis, gas separation, or liquid purification due to its porous matrix or as binder-free electrodes in electronics. To demonstrate the multifunctionality, the aerogels are successfully decorated with metal nanoparticles (Ag) and metal oxide nanoparticles (TiO<sub>2</sub>) by <i>in situ</i> synthesis, coated by the conductive polymer (PEDOT:PSS), and carbonized to yield conductive aerogels. This approach is found to be a universal way to prepare highly porous anisotropic aerogels.
Interference networks with local view: A distributed optimization approach (2009)

In practice, a node in a network learns the channel through local message passing and obtains a local view of the network. Pure wireless message passing as well as mixed wireless and wireline message passing are considered in this paper. We study the distributed optimization of sum-rate for a class of deterministic interference networks with local view. A connection based utility function is designed for each user to exploit the local knowledge. This utility design turns out to be a potential game with sum-rate as the potential function. For the one-to-many channel with 1.5 wireless rounds of message passing, we show that there is a unique Nash equilibrium and using this strategy, the sum capacity can be achieved. We provide a sufficient condition for which a topology does not have unique Nash equilibrium. Then we consider the scenario that the network size and the users IDs are provided to each user. For various mixed wireless and wireline message passing patterns, including wireline at transmitter/receiver side and sequential/concurrent message passing scheduling, we identify whether a three-user interference network can achieve the sum capacity in a distributed fashion. Compared with the 1.5 pure wireless rounds of message passing, the results show that 2.5 mixed wireless and wireline rounds of message passing can significantly improve the system performance of three-user interference networks. We also derive some sufficient conditions for general K-user interference networks such that the sum capacity can not be achieved based on each user's local view.
Silica nanomachining using laser plasma soft x rays (2006)

In order to demonstrate silica nanomachining, the authors fabricated line-and-space contact masks with spaces of 53 and 70nm on silica glass plates, followed by irradiation with laser plasma softx rays (LPSXs) with wavelengths around 10nm. Trenches with the narrowest width of 54nm and an aspect ratio of ∼1 were fabricated by the LPSX irradiation through the contact masks. It was also clarified that silica glass can be machined by irradiation with LPSXs in the wavelength range of 6–30nm in Ar gas which was used as an x-ray bandpass filter.
Design and characterization of thin multiple aperture infrared cameras (2009)

We describe a multiple-aperture long-wave infrared camera built on an uncooled microbolometer array with the objective of decreasing camera thickness. The 5 mm thick optical system is an f/1.2 design with a 6.15 mm effective focal length. An integrated image is formed from the subapertures using correlation-based registration and a least gradient reconstruction algorithm. We measure a 131 mK NETD. The system's spatial frequency is analyzed with 4 bar targets. With proper calibration, our multichannel interpolation results recover contrast for targets at frequencies beyond the aliasing limit of the individual subimages.
Covering indexes for branching path queries (2002)

In this paper, we ask if the traditional relational query acceleration techniques of summary tables and covering indexes have analogs for branching path expression queries over tree- or graph-structured XML data. Our answer is yes --- the forward-and-backward index already proposed in the literature can be viewed as a structure analogous to a summary table or covering index. We also show that it is the smallest such index that covers all branching path expression queries. While this index is very general, our experiments show that it can be so large in practice as to offer little performance improvement over evaluating queries directly on the data. Likening the forward-and-backward index to a covering index on all the attributes of several tables, we devise an index definition scheme to restrict the class of branching path expressions being indexed. The resulting index structures are dramatically smaller and perform better than the full forward-and-backward index for these classes of branching path expressions. This is roughly analogous to the situation in multidimensional or OLAP workloads, in which more highly aggregated summary tables can service a smaller subset of queries but can do so at increased performance. We evaluate the performance of our indexes on both relational decompositions of XML and a native storage technique. As expected, the performance benefit of an index is maximized when the query matches the index definition.
Engineering Li/Na selectivity in 12-Crown-4–functionalized polymer membranes (2021)

Lithium is widely used in contemporary energy applications, but its isolation from natural reserves is plagued by time-consuming and costly processes. While polymer membranes could, in principle, circumvent these challenges by efficiently extracting lithium from aqueous solutions, they usually exhibit poor ion-specific selectivity. Toward this end, we have incorporated host-guest interactions into a tunable polynorbornene network by copolymerizing 1) 12-crown-4 ligands to impart ion selectivity, 2) poly(ethylene oxide) side chains to control water content, and 3) a crosslinker to form robust solids at room temperature. Single salt transport measurements indicate these materials exhibit unprecedented reverse permeability selectivity (∼2.3) for LiCl over NaCl-the highest documented to date for a dense, water-swollen polymer. As demonstrated by molecular dynamics simulations, this behavior originates from the ability of 12-crown-4 to bind Na<sup>+</sup> ions more strongly than Li<sup>+</sup> in an aqueous environment, which reduces Na<sup>+</sup> mobility (relative to Li<sup>+</sup>) and offsets the increase in Na<sup>+</sup> solubility due to binding with crown ethers. Under mixed salt conditions, 12-crown-4 functionalized membranes showed identical solubility selectivity relative to single salt conditions; however, the permeability and diffusivity selectivity of LiCl over NaCl decreased, presumably due to flux coupling. These results reveal insights for designing advanced membranes with solute-specific selectivity by utilizing host-guest interactions.
Supercritical Fuel Measurements (2012)

Abstract : Work was performed on stimulated scattering for fuel property measurements at high temperatures and high pressures. The performance of a two-stage double-pass amplifier was improved to achieve required pulse energies and pulse lengths. Frequency modulation methods were developed to achieve rapid and sensitive stimulated scattering measurements. Frequency domain methods were developed to measure the refractive index to support conversion of spectroscopic parameters to physical parameters. System modifications were performed to convert the static measurement cell to a flowing cell. Stimulated Rayleigh scattering measurements were performed in JP-8 jet fuel. Analysis of high-temperature / high-pressure data in hexane provides evidence of the presence of an instability zone in the supercritical regime. Single-shot stimulated scattering measurements were performed with the stimulated Rayleigh scattering technique.
40Gb/s DP-NRZ-QPSK signal generation using a dual-polarization quad-parallel mach-zehnder modulator (2010)

We demonstrated a 40Gb/s DP-NRZ-QPSK signal generation using a dual-polarization quad-parallel MZ modulator fabricated on LiNbO 3 . Two orthogonally polarized QPSK signals were successfully demodulated by digital homodyne receiver.
The Use of Steroid Sulfatase Inhibitors as a Novel Therapeutic Strategy Against Hormone-Dependent Endometrial Cancer (2008)

The past few years have seen an increase in the reported incidence of endometrial carcinoma, one of the most frequently diagnosed malignancies of the female genital tract. Estrogen production is vital for the mitogenesis of endometrial tumors. Inhibition of steroid sulfatase (STS), an enzyme responsible for the synthesis of steroids with estrogenic properties, may represent a novel therapeutic target for this type of cancer. This study investigates the effects of STX64 (also known as 667Coumate and BN83495) and STX213, two potent STS inhibitors, on hormone-dependent endometrial cancer cell growth in vivo. When tested in intact mice with endometrial cancer xenografts, STX64 had limited effect on tumor growth. In contrast, the microtubule disruptor STX140 reduced tumor growth by 55%. In a hormone-dependent endometrial xenograft model in ovariectomized mice, both STX64 and STX213 given orally, daily at 1 mg/kg significantly inhibited tumor growth by 48 and 67%, respectively. However, when given orally at 1 mg/kg once weekly, only STX213 still inhibited tumor proliferation. At a higher dose of STX64 (10 mg/kg, orally, daily), a greater tumor growth inhibition of 59% was observed. Liver and tumor STS activity was completely inhibited in all daily treatment groups. Plasma estradiol (E2) levels were also significantly decreased. A significant correlation was observed between plasma E2 concentrations and STS activity, indicating the importance of circulating E2 on tumor growth. This novel study demonstrates for the first time that STS inhibitors are potent inhibitors of endometrial cancer growth in nude mice.
Highly Reliable Key Generation From Electrocardiogram (ECG) (2016)

Traditional passwords are inadequate as cryptographic keys, as they are easy to forge and are vulnerable to guessing. Human biometrics have been proposed as a promising alternative due to their intrinsic nature. Electrocardiogram (ECG) is an emerging biometric that is extremely difficult to forge and circumvent, but has not yet been heavily investigated for cryptographic key generation. ECG has challenges with respect to immunity to noise, abnormalities, etc. In this paper, we propose a novel key generation approach that extracts keys from real-valued ECG features with high reliability and entropy in mind. Our technique, called interval optimized mapping bit allocation (IOMBA), is applied to normal and abnormal ECG signals under multiple session conditions. We also investigate IOMBA in the context of different feature extraction methods, such as wavelet, discrete cosine transform, etc., to find the best method for feature extraction. Experiments of IOMBA show that 217-, 38-, and 100-bit keys with 99.9%, 97.4%, and 95% average reliability and high entropy can be extracted from normal, abnormal, and multiple session ECG signals, respectively. By allowing more errors or lowering entropy, key lengths can be further increased by tunable parameters of IOMBA, which can be useful in other applications. While IOMBA is demonstrated on ECG, it should be useful for other biometrics as well.
SPICE-Compatible Equivalent Circuit Models for Accurate Time-Domain Simulations of Passive Photonic Integrated Circuits (2022)

Passive photonic integrated circuits (PICs) can be easily characterized in the frequency-domain, but their accurate time-domain performance evaluation is a hurdle for system-level designers, especially when dealing with resonant circuits having highly dispersive behavior, such as ring resonators. In this paper, a new equivalent circuit modeling and simulation approach is proposed, based on the Complex Vector Fitting algorithm, able to perform accurate and robust time-domain simulations of passive PICs directly in standard SPICE simulators. The proposed modeling technique starts from scattering parameters of passive PICs, and is able to capture linear and high order dispersion, backscattering, and wavelength dependent effects. Considering the different nature of optical and electronic signals, a novel concept of equivalent voltage and current for optical waveguides is proposed to simplify the optical to electronic ports conversion and to make it possible to connect and terminate the equivalent circuit models as needed in SPICE simulators, natively supporting bidirectional signal propagation in a waveguide. This work provides a precise and reliable solution to evaluate time-domain characteristics of passive PICs and to access any internal nodes within a circuit, such as the signals inside a ring resonator. Three examples of time-domain simulations of passive PICs in commercial SPICE simulators are presented to demonstrate the flexibility and advantages of the proposed technique.