gebhart/patrepeval huggingface dataset:
Methods to Reduce Air-charge Characterization Data for High Degree of Freedom Engines (2004)

&lt;div class="htmlview paragraph"&gt;Current methods of storing critical engine operating parameters often rely on lookup interpolation functions. A drawback to lookup interpolations is that as the number of independent variables increases, the function's dimensions increase from tables to cubes to hypercubes of data. A sparser collection of data may serve if the strict orthogonal structure of lookup functions is not required. Instead of forming a matrix of data for every combination of input variables, a few critical data points are stored with their independent variables. The available data can be used to estimate parameters at new input values (typically from current measurements) by relating the available data by its distance from the new inputs. An inverse distance weighting scheme is used to calculate the output of the function. A dual independent variable cam timing engine offers an example where the air charge coefficients used for transient air charge and inferred manifold pressure can be more efficiently stored without a large loss in estimation accuracy.&lt;/div&gt;
Norepinephrine release in the immature ovary is regulated by autoreceptors and neuropeptide-Y. (1992)

Experiments were undertaken to study the role that neuropeptide-Y (NPY) and adrenergic autoreceptors may play in the regulation of norepinephrine (NE) release from the rat ovary. Ovaries from 28- to 32-day-old rats were preincubated with [3H]NE, and the release of the recently taken up catecholamine in response to electric field stimulation was assessed. The release was strictly dependent on the presence of extracellular calcium and decreased when the frequency of stimulation was increased. This drop in [3H]NE release was significantly reversed by exposure of the ovaries during stimulation to yohimbine, a selective alpha 2-adrenoreceptor blocker. The existence of prejunctional alpha 2-adrenergic autoreceptors in ovarian nerves was further suggested by the ability of exogenous NE to mimic the inhibitory effect of high frequency stimulation. NPY inhibited by 40% the release of [3H]NE induced by electrical stimulation. The specificity of this effect and its prejunctional nature were demonstrated by the finding that avian pancreatic polypeptide, a structural homolog of NPY that is not recognized by prejunctional NPY receptors of the Y2 subtype, failed to alter the induced release of [3H]NE. Neither NPY, avian pancreatic polypeptide, nor peptide-YY, another member of the pancreatic polypeptide fold family, altered progesterone or estradiol secretion from whole ovaries or granulosa cells in culture, suggesting that NPY (and its structural homologs) does not directly affect ovarian steroidogenesis. The results suggest that 1) the release of NE from ovarian sympathetic nerves is subjected to a dual modulatory influence provided by NE itself and NPY; and 2) this regulatory effect is exerted via specific prejunctional receptors. Such NE/NPY actions are likely to regulate the availability of NE to its postsynaptic receptors during ovarian development and adult function. The fact that NPY is mostly released during high frequency stimulation raises the possibility of NPY involvement in ovarian dysfunctions associated with situations of enhanced sympathetic discharge, such as strenuous exercise and psychogenic amenorrhea.
Additional file 6 of Cherenkov luminescence measurements with digital silicon photomultipliers: a feasibility study (2015)

Effect of the HDC cells removal algorithm, p = 0 %. Labels and legend follow Fig. 12, and plot positions refer to die positions in the die (Fig. 2-center). (PNG 50 kb)
Trapping of molecules in alkanethiol self-assembled monolayer matrices (1999)

Reactions of NH+ 4 in water solutions with self-assembled monolayer (SAM) surfaces result in the deposition of ammonia in the monolayers. Similarities between this and the soft landing of ions seen in low energy gas phase ion—surface collisions suggest that monolayers can be used as matrices to preserve species. Ammonia can be incorporated only into thicker SAMs such as those made from octadecanethiol. Reactions with larger ions do not lead to trapping. Trapped ammonia desorbs during prolonged exposure of the SAMs to vacuum.
Initial observations of Jinhua Qinggan Granules, a Chinese medicine, in the mitigation of hospitalization and mortality in high-risk elderly with COVID-19 infection: A retrospective study in an old age home in Hong Kong (2022)

OPINION article Front. Med., 27 July 2022Sec. Infectious Diseases – Surveillance, Prevention and Treatment https://doi.org/10.3389/fmed.2022.948149
Photo-Realistic Rendering of Blond Hair (2004)

We present a method for photo-realistic hair rendering, which is based on light scattering from (human) hair fibers. In contrast to existing approaches our method gives realistic results also for light hair types and for close-ups. These results are obtained by using a “near-field ” model taking into account different scattering components and indirect illumination. Our near-field model is a generalization of previously published methods that can be seen as far-field models. Nevertheless our more general shading model can be used computationally as efficiently as the previous ones. 1
2nd multimodal interfaces for automotive applications (MIAA 2010) (2010)

This paper summarizes the main objectives of the 2nd IUI workshop on multimodal interfaces for automotive applications (MIAA 2010).
Non-volatile memory for checkpoint storage (2023)

A system, method and computer program product for supporting system initiated checkpoints in high performance parallel computing systems and storing of checkpoint data to a non-volatile memory storage device. The system and method generates selective control signals to perform checkpointing of system related data in presence of messaging activity associated with a user application running at the node. The checkpointing is initiated by the system such that checkpoint data of a plurality of network nodes may be obtained even in the presence of user applications running on highly parallel computers that include ongoing user messaging activity. In one embodiment, the non-volatile memory is a pluggable flash memory card.
Abstract A49: Pharmacological inhibition of PIM kinases in combination with chemotherapeutic drugs decreases cell viability of pancreatic cancer cells (2016)

Abstract Current drug treatments have proven ineffective in pancreatic ductal adenocarcinoma (PDAC) as chemoresistance is a common occurrence in this disease. In order to improve survival rates, a combination treatment regimen of anti-cancer drugs will most likely be needed. The oncogenic serine/threonine PIM kinase family has been shown to regulate drug resistance in various cancers, including pancreatic cancer. Several PIM kinase inhibitors have been developed over the years and tested against a number of cancers, including solid tumors. Previous studies in our laboratory have shown a potential synergistic effect on cell viability of PDAC cells when treated with the PIM kinase inhibitor SGI-1776 and gemcitabine. Unfortunately, due to medical problems occurring during Phase I clinical trials , clinical studies using SGI-1776 were terminated. This led to the development by Tolero Pharmaceuticals of a more selective second generation PIM kinase inhibitor, TP-3654. However, to our knowledge no research has been conducted on the interaction of TP-3654 with gemcitabine or other FDA-approved chemotherapeutics. To address this concern, a 384-well high-content cell viability assay was designed to assess synergism between TP-3654 and the National Cancer Institute (NCI) catalog of 88 FDA-approved chemotherapeutics. Using high-content automated microscopy and image analysis, we acquired total cell counts and other important cellular data, such as nuclear and cell morphology. While some drug combinations with TP-3654 proved ineffective, decreased cell viability was observed in several drug classes, including hormonal agents, mTOR inhibitors, and alkylating agents. Compounds causing significant cytotoxicity in combination with TP-3654 were further evaluated to not only confirm synergism, but to potentially understand the cellular mechanisms and signaling pathways involved. Additional studies will include testing TP-3654 with non-chemotherapeutic compounds and purified natural products. The results of these studies could be used to help develop better drug combination strategies to treat pancreatic cancer and increase the survival rate of patients. Citation Format: Brittany K. Nixon, Qingping He, Vandana Singh, Sarah A. Compton, Steve Warner, David Bearss, Jonathan Z. Sexton, Antonio T. Baines.{Authors}. Pharmacological inhibition of PIM kinases in combination with chemotherapeutic drugs decreases cell viability of pancreatic cancer cells. [abstract]. In: Proceedings of the AACR Special Conference on Pancreatic Cancer: Advances in Science and Clinical Care; 2016 May 12-15; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2016;76(24 Suppl):Abstract nr A49.
Direct laser interference patterning, 20 years of development: from the basics to industrial applications (2017)

Starting from a simple concept, transferring the shape of an interference pattern directly to the surface of a material, the method of Direct Laser Interference Patterning (DLIP) has been continuously developed in the last 20 years. From lamp-pumped to high power diode-pumped lasers, DLIP permits today for the achievement of impressive processing speeds even close to 1 m<sup>2</sup>/min. The objective: to improve the performance of surfaces by the use of periodically ordered micro- and nanostructures. This study describes 20 years of evolution of the DLIP method in Germany. From the structuring of thin metallic films to bulk materials using nano- and picosecond laser systems, going through different optical setups and industrial systems which have been recently developed. Several technological applications are discussed and summarized in this article including: surface micro-metallurgy, tribology, electrical connectors, biological interfaces, thin film organic solar cells and electrodes as well as decorative elements and safety features. In all cases, DLIP has not only shown to provide outstanding surface properties but also outstanding economic advantages compared to traditional methods.
Robust low-complexity multichannel equalization for dereverberation (2013)

Multichannel equalization of acoustic impulse responses (AIRs) is an important approach for dereverberation. Since AIRs are inevitably estimated with system identification error (SIE), it is necessary to develop equalization designs that are robust to such SIE, in order for dereverberation processing to be beneficial. We present here a novel subband equalizer employing the relaxed multichannel least squares (RMCLS) algorithm in each subband. We show that this new structure brings improved performance in dereverberation as well as a reduction in computational load by up to a factor of more than 90 in our experiments. We then develop a novel controller for the dereverberation processing in subbands that guarantees robustness to even very severe SIEs by backing off dereverberation in any subband with excessively high levels of SIEs.
(Invited) Stabilizing and Enhancing Lithium-Ion Batteries with Chemically Inert 2D Materials (2022)

Efficient energy storage systems represent a critical technology across many sectors including consumer electronics, electrified transportation, and a smart grid accommodating intermittent renewable energy sources. Arguably, the most important advance in energy storage over the past three decades is the lithium-ion battery, which was recently recognized with the Nobel Prize in Chemistry. However, despite its many successes, issues related to safety, energy density, charging time, and operating temperature range have hindered the realization of the full potential of lithium-ion battery technology, particularly in large-scale applications such as grid-level storage and full electrification of transportation networks. Nanostructured materials were once thought to present compelling opportunities for next-generation lithium-ion batteries, but inherent problems related to high surface area to volume ratios at the nanometer-scale (e.g., undesirable surface chemical interactions between electrodes and electrolytes) have impeded their adoption for commercial applications. This talk will explore how the chemical inertness of select two-dimensional (2D) materials are driving a resurgence in nanostructured lithium-ion battery materials [1]. For example, conformal graphene coatings on lithium-ion battery cathode powders mitigate surface degradation and minimize the formation of the solid electrolyte interphase, thus improving cycling stability [2]. In addition, the high electrical conductivity of graphene reduces cell impedance, resulting in enhanced kinetics that enable high-rate capability and low-temperature performance down to –20 °C [3]. On the other hand, ionogel electrolytes based on ionic liquids and hexagonal boron nitride (hBN) nanoplatelets provide safe, high-rate operation at high temperatures up to 175 °C, which represents the highest operating temperature to date for solid-state lithium-ion batteries [4,5]. The strong interfacial interactions between hBN and ionic liquids further enable novel electrolyte architectures based on layered heterostructure ionogels that result in unprecedently high energy densities and rate performance for solid-state batteries [6]. [1] H. Bergeron, et al. , Chemical Reviews , 121 , 2713 (2021). [2] K.-Y. Park, et al. , Advanced Energy Materials , 10 , 2001216 (2020). [3] K.-Y. Park, et al. , Advanced Materials , DOI: 10.1002/adma.202106402 (2021). [4] W. J. Hyun, et al. , ACS Nano , 13 , 9664 (2019). [5] W. J. Hyun, et al. , Advanced Energy Materials , 10 , 2002135 (2020). [6] W. J. Hyun, et al. , Advanced Materials , 33 , 2007864 (2021).
Top-gated Thin Film FETs Fabricated from Arrays of Self-aligned Semiconducting Carbon Nanotubes (2008)

In this paper, we present a new approach for making active carbon nanotube (CNT) electrical devices and demonstrate the first aligned CNT array field effect transistors (FET) from 99% pure separated semiconducting nanotubes. Through evaporation-driven deposition of predominantly semiconducting nanotubes from the liquid phase, we have fabricated aligned, thin-film CNT devices with high on-state currents. The fabrication scheme presented here provides a versatile production method translatable to other substrates such as flexible plastics.
Adaptive density control in heterogeneous wireless sensor networks with and without power management (2010)

The authors study the design of heterogeneous two-tier wireless sensor networks (WSNs), where one tier of nodes is more robust and computationally intensive than the other tier. The authors find the ratios of densities of nodes in each tier to maximise coverage and network lifetime. By employing coverage processes and optimisation theory, the authors show that any topology of WSN derived from random deployments can result in maximum coverage for the given node density and power constraints by satisfying a set of conditions. The authors show that network design in heterogeneous WSNs plays a key role in determining key network performance parameters such as network lifetime. The authors discover a functional relationship between the redundancy, density of nodes in each tier for active coverage and the network lifetime. This relationship is much less pronounced in the absence of heterogeneity. The results of this work can be applied to network design of multi-tier networks and for studying the optimal duty cycles for power saving states for nodes in each tier.
Automatic Recognition of Abnormal Respiratory Events During Sleep by a Pacemaker Transthoracic Impedance Sensor (2004)

The RDI monitoring function appears to be of value in screening pacemaker patients for SAS. Its performance is comparable to existing simple screening techniques. The ability to permanently monitor respiration, in combination with other diagnostic capabilities (such as Holter functions), presents a unique opportunity to monitor the association between arrhythmias and disturbances of breathing during sleep.
Comparing Valdecoxib, Hydrocodone/acetaminophen, And Placebo In Relieving Golf-related Osteoarthritic Back Pain And Improving Swing Performance (2005)

Introduction Data supports the efficacy of selective COX-2 inhibitors in chronic treatment of osteoarthritis (OA). However, the efficacy of a single dose for the acute or pre-emptive relief of back pain and restoration of function during the high demand sport of golf has not been documented. Purpose To provide data on the efficacy of the COX-2 inhibitor valdecoxib 10 mg (BextraTM) compared to hydrocodone/acetaminophen 5/500 mg (VicodinTM) and placebo in reducing or relieving acute back pain induced by the golf swing in patients with OA of the lumbar spine. This study also examined the effects of these agents on golf swing performance. Methods This randomized, double-blind, cross-over, 12 week study compared the effects of a single dose of valdecoxib (10 mg), hydrocodone/acetaminophen (5/500 mg), and placebo, on an initial baseline measurement of subjective pain (SF-36, Oswestry) and the biomechanical assessment of the golf swing as measured during simulated golf play. A drug wash-out period of ≥7–10 days was utilized between each treatment arm. Golf swing performance was measured via Motion Analysis (240 Hz, 37 markers, 15 segment body) with emphasis on hip and shoulder trunk rotations and peak club head velocity. Data between treatement arms were compared with a RMANOVA (p≤.05) with a Bonferroni adjustment for post-hocs. Results Valdecoxib and hydrocodone/acetaminophen were clinically equal to each other and statistically superior to placebo and baseline measures in improving baseline SF-36 and Oswestry scores. These drugs also promoted greater hip (p≤.05) and shoulder rotations (p≤.05) and increased club head speed (p≤.05) compared to placebo and baseline measures. Conclusion In senior golfers with low back OA, a pre-emptive dose of valdecoxib (10 mg) is as effective as the opioid analgesic, hydrocodone/acetaminophen (5/500 mg), in alleviating golf-induced low back pain and improving golf swing performance as measured by greater hip and shoulder rotations as well as club head speed.
Towards Training Probabilistic Topic Models on Neuromorphic Multi-Chip Systems (2018)

Probabilistic topic models are popular unsupervised learning methods, including probabilistic latent semantic indexing (pLSI) and latent Dirichlet allocation (LDA). By now, their training is implemented on general purpose computers (GPCs), which are flexible in programming but energy-consuming. Towards low-energy implementations, this paper investigates their training on an emerging hardware technology called the neuromorphic multi-chip systems (NMSs). NMSs are very effective for a family of algorithms called spiking neural networks (SNNs). We present three SNNs to train topic models.The first SNN is a batch algorithm combining the conventional collapsed Gibbs sampling (CGS) algorithm and an inference SNN to train LDA. The other two SNNs are online algorithms targeting at both energy- and storage-limited environments. The two online algorithms are equivalent with training LDA by using maximum-a-posterior estimation and maximizing the semi-collapsed likelihood, respectively.They use novel, tailored ordinary differential equations for stochastic optimization. We simulate the new algorithms and show that they are comparable with the GPC algorithms, while being suitable for NMS implementation. We also propose an extension to train pLSI and a method to prune the network to obey the limited fan-in of some NMSs.
Sensitometric response of CdZnTe detectors for digital radiography (2002)

The sensitometric response of the CdZnTe semiconductor detectors, within the X-ray diagnostic energy range, have been studied with the aim of optimizing the image quality parameters of these solid state-ionization devices. The detected signal and noise contributions were measured and related to the tube setting current parameters. Furthermore, the detector contrast has been experimentally determined. The experimental results indicate that CdZnTe detectors have high resistivity, high signal-to-noise ratio, and high detector contrast resolution. Therefore, they appear to be potential candidates for imaging applications with applications in X-ray digital radiography, dual-energy radiography, and computed tomography (CT).
Isolation and characterization of antimicrobial-resistantEscherichia colifrom national horse racetracks and private horse-riding courses in Korea (2016)

Limited information is available regarding horse-associated antimicrobial resistant (AR) Escherichia (E.) coli. This study was designed to evaluate the frequency and characterize the pattern of AR E. coli from healthy horse-associated samples. A total of 143 E. coli (4.6%) were isolated from 3,078 samples collected from three national racetracks and 14 private horse-riding courses in Korea. Thirty of the E. coli isolates (21%) showed antimicrobial resistance to at least one antimicrobial agent, and four of the AR E. coli (13.3%) were defined as multi-drug resistance. Most of the AR E. coli harbored AR genes corresponding to their antimicrobial resistance phenotypes. Four of the AR E. coli carried class 1 integrase gene (intI1), a gene associated with multi-drug resistance. Pulsed-field gel electrophoretic analysis showed no genetic relatedness among AR E. coli isolated from different facilities; however, cross-transmissions between horses or horses and environments were detected in two facilities. Although cross-transmission of AR E. coli in horses and their environments was generally low, our study suggests a risk of transmission of AR bacteria between horses and humans. Further studies are needed to evaluate the risk of possible transmission of horse-associated AR bacteria to human communities through horse riders and horse-care workers.
Development of Natural Product-Derived Receptor Tyrosine Kinase Inhibitors Based on Conservation of Protein Domain Fold (2003)

Receptor tyrosine kinases (RTKs) such as Tie-2, IGF1R, Her-2/Neu, EGFR, and VEGFR1-3 play crucial roles in the control of cell growth and differentiation. Inhibition of such RTKs has become a major focus of current anticancer drug development, and therefore the discovery of new classes of inhibitors for these signal-transducing proteins is of prime importance. We have recently proposed a novel concept for improving the hit-finding process by employing natural products as biologically validated starting points in structural space for compound library development. In this concept, natural products are regarded as evolutionary chosen ligands for protein domains which are structurally conserved yet genetically mobile. Here we report on the discovery of novel and highly selective VEGFR-2 and -3, Tie-2, and IGF1R inhibitors derived from the naturally occurring Her-2/Neu kinase inhibitor nakijiquinone C and developed on the basis of this concept. Based on the structure of the natural product, a small library (74 members) was synthesized and investigated for inhibition of kinases with highly similar ATP-binding domains. The library yielded inhibitors with IC(50)s in the low micromolar range with high frequency (7 out of 74). In particular, four inhibitors of Tie-2 were found, a kinase critically involved in the formation of new blood vessels from preexisting ones (angiogenesis) and believed to be a new promising target in antitumor therapy. These results support the "domain concept". To advance the development of improved inhibitors, extensive molecular modeling studies were undertaken, including the construction of new homology models for VEGFR-2 and Tie-2. These studies revealed residues in the kinase structure which are crucial to the development of tailor-made receptor tyrosine kinase inhibitors.