gebhart/patrepeval huggingface dataset:
FM2u-Net: Face Morphological Multi-Branch Network for Makeup-Invariant Face Verification (2020)

It is challenging in learning a makeup-invariant face verification model, due to (1) insufficient makeup/non-makeup face training pairs, (2) the lack of diverse makeup faces, and (3) the significant appearance changes caused by cosmetics. To address these challenges, we propose a unified Face Morphological Multi-branch Network (FMMu-Net) for makeup-invariant face verification, which can simultaneously synthesize many diverse makeup faces through face morphology network (FM-Net) and effectively learn cosmetics-robust face representations using attention-based multi-branch learning network (AttM-Net). For challenges (1) and (2), FM-Net (two stacked auto-encoders) can synthesize realistic makeup face images by transferring specific regions of cosmetics via cycle consistent loss. For challenge (3), AttM-Net, consisting of one global and three local (task-driven on two eyes and mouth) branches, can effectively capture the complementary holistic and detailed information. Unlike DeepID2 which uses simple concatenation fusion, we introduce a heuristic method AttM-FM, attached to AttM-Net, to adaptively weight the features of different branches guided by the holistic information. We conduct extensive experiments on makeup face verification benchmarks (M-501, M-203, and FAM) and general face recognition datasets (LFW and IJB-A). Our framework FMMu-Net achieves state-of-the-art performances.
Current Sensing Integration with Lead Frames in 6-in-1 IGBT Modules (2018)

To improve the power density and reliability of the energy conversion systems, lead frames have been used in power modules as replacement for bond wires. Giant magnetoresistive (GMR) detectors have already been integrated in the external screw terminals of 2-in-1 IGBT modules for current sensing. To achieve a higher level of sensing integration, this work introduces methodologies for GMR integration inside 6-in-1 IGBTs with customized lead frames. A methodology for lead frame design suitable for GMR integration is presented. This design can be scaled for module terminals and external bus bars. Inter-phase and intra-module decoupling are implemented to decouple the cross-coupled fields from adjacent phase currents and die region currents. The closed-loop control of a three-phase inverter for an AC machine is realized based on the integrated GMR sensing in the lead frame module.
Physical, chemical, and isotopic data from groundwater in the watershed of Mirror Lake, and in the vicinity of Hubbard Brook, near West Thornton, New Hampshire, 1983 to 1997 (2013)

Research on the hydrogeologic setting of Mirror Lake near West Thornton, New Hampshire (43° 56.5’ N, 71° 41.5’ W), includes the study of the physical, chemical, and isotopic characteristics of groundwater in the vicinity of the lake and nearby Hubbard Brook. Presented here are those physical, chemical, and isotopic data for the period 1983 to 1997. Data were collected from observation wells installed in glacial drift and bedrock, as well as from one domestic well in the general area of the lake and Hubbard Brook. Also presented are data for Mirror Lake for August 1, 1993, to place groundwater data in context with chemical and isotopic characteristics of the lake.
The Automatic Implantable Cardioverter-Defibrillator (1992)

From November 1982 through April 1989, 111 patients with refractory sustained ventricular tachycardia/fibrillation had the automatic cardioverter-defibrillator implanted at our institution, the first community hospital involved in implantation of such a device. We have reviewed our long-term clinical experience to assess the feasibility, learning curve, and efficacy of device implantation in a facility with cardiac electrophysiology expertise but without open-heart surgery facilities. All patients were considered inoperable or at high risk for other concomitant surgery. Eighty-six patients (77%) underwent uneventful implantation. Nine patients (8%) died prior to hospital discharge. Operative mortality declined from 10.9% to 5.4% during the first half (55 patients; November 1982 through September 1986) and second half (56 patients; October 1986 through April 1989) of the experience. Other postoperative complications occurred in 16 patients (14%), 12 of whom experienced complications during the first half of the experience. At 22 +/- 20 (mean +/- SD) months' follow-up, 78 (76%) of 102 patients discharged were alive, and 24 patients (24%) had died. Fifty patients (49%) had experienced at least one automatic cardioverter-defibrillator discharge associated with hypotensive symptoms. The actuarial incidence of sudden death at 1, 2, and 3 years was 1.2%, 5.5%, and 6.2%, respectively. We concluded that the automatic implantable cardioverter-defibrillator is an effective therapy for refractory ventricular tachycardia/fibrillation and that device implantation at community hospitals with an experienced cardiac electrophysiology team is both feasible and practical.
Chilcot: physical and mental legacy of Iraq war on UK service personnel (2016)

Long term consequences remain unknown, particularly for “unexpected survivors”

The much awaited Chilcot report focused on the legitimacy of the UK going to war in Iraq.1 But the UK citizens most directly affected by the war were members of the armed forces and their families. A total of 179 British service personnel were killed in the conflict, and many more received life changing physical and mental injuries. The Ministry Of Defence reports a total of 5970 casualties, including deaths up to July 2009.2

In April 2003 the UK Ministry of Defence commissioned an independent study of the health and wellbeing of Iraq war veterans (Chilcot, 16.2, 58-). This study, now completing its third wave of data collection, compared military personnel who had or had not been to Iraq, and found no new “Iraq war syndrome”3; no significant increase in probable post-traumatic stress disorder (PTSD) or common mental health disorders; and only a modest increase in …
Field-Directed Self-Assembly of Magnetic Nanoparticles (2004)

Fe3O4 nanoparticles in the size range of 8−12 nm have been prepared and allowed to self-assemble on GaAs substrates in the presence of strong magnetic fields. A long range ordering is observed in which the particles self-assemble into a distribution of elongated clusters with a predominant orientation lengthwise along the field direction. Hysteresis loops measured parallel and perpendicular to the alignment direction show substantial directional dependence. The coercive fields in the direction parallel to the alignment field are larger than those perpendicular to it by 57% and 136% at 100 and 5K, respectively. A broad peak is observed in magnetization profiles obtained with zero- field-cooling.
P06.09 Anti-hPSMA CAR engineered NK-92 cells: An off-the-shelf cellular therapeutic for targeted elimination of prostate cancer cells (2020)

<h3>Background</h3> Adoptive cell therapy of malignant diseases takes advantages of the cellular immune system to recognize and destroy cancer cells. Despite the remarkable success in B cell malignancies after adoptive transfer of CD19 CAR T cells, CAR T cell therapy in solid tumors has shown less encouraging clinical results, above all caused by tumor escape mechanisms.In order to overcome such limitations, NK-92, a permanent and IL-2-dependent cell line with a high cytotoxicity <i>in vitro</i>, has been engineered in preclinical models with CAR. In this project, we exploited a CAR directed against the human antigen hPSMA that is overexpressed in prostate tumors. This project aimed at transducing NK-92 cell line to obtain a hPSMA-specific CAR NK-92 cell population, to be thereafter characterized <i>in vitro</i> and <i>in vivo</i> for antigen-specific functional activity. <h3>Materials and Methods</h3> NK-92 cell line was transduced with a lentiviral vector (LV) carrying a CAR anti-hPSMA. The cell population obtained was then sorted and analyzed for degranulation capacity, IFNγ production and lytic activity against hPSMA<sup>+</sup> (PC3-hPSMA, LNCaP) or hPSMA<sup>-</sup>tumor cell lines. <i>In vivo</i> therapeutic efficacy of CAR-transduced NK-92 was evaluated initially using Winn-Assay and than in subcutaneous and orthotopic tumor models. <h3>Results</h3> CAR-expressing LV efficiently transduced NK-92 cells, which in turn produced cytokines, degranulated and exerted a relevant cytotoxic upon challenge with PSMA+ prostate tumor cells, irrespective of 10 Gy γ-irradiation. In all the <i>in vivo</i>, tumor models CAR-transduced NK-92 shown a statistically significant inhibition of tumor growth. <h3>Conclusions</h3> Chimeric antigen receptor-engineered NK-92 could offer a valid and cost-effective alternative to primary CAR NK or T cells, in particular in cases, where a suitable donor is not available or the sophisticated infrastructure needed for cell isolation, expansion and genetic modification is missing. This work demonstrates that CAR-engineered NK-92 cells display a high and specific recognition of hPSMA+ PC both <i>in vitro</i> as is <i>in vivo</i>, and could represent an efficient strategy as a new therapeutic intervention against prostate carcinoma, thus paving the way to an Off-The-Shelf cellular therapeutic for targeted elimination of cancer cells and induction of protective antitumor immunity. <h3>Disclosure Information</h3> <b>G. Zuccolotto:</b> None. <b>A. Penna:</b> None. <b>I.M. Montagner:</b> None. <b>D. Carpanese:</b> None. <b>A. Rosato:</b> None.
Highly luminescent monolayer protected Ag56Se13S15clusters (2016)

Highly luminescent monolayer protected mixed silver chalcogenide clusters showing high sensitivity towards mercury ions.
Axial Equilibrium Distance and Positioning of Particles in a Laminar Tube Flow (2013)

Abstract Particle transport in a laminar tube flow at low Reynolds numbers leads to accumulation of particles at specific equilibrium radii. The equilibrium radius depends on the particle size. Small particles find their equilibrium radius near the wall and large particles near the tube axis. During their radial migration to the equilibrium position, the particles move in axial direction with the flow. In an experimental setup, the axial equilibrium distance is measurement for several tube Reynolds numbers. The axial equilibrium distance is the distance a particle migrates in the flow direction, until it reaches its radial equilibrium position. The results are compared with CFD‐simulations of single particle movement in a laminar tube flow.
Virus-Like Particle Secretion and Genotype-Dependent Immunogenicity of Dengue Virus Serotype 2 DNA Vaccine (2014)

Five genotype-specific dengue virus serotype 2 (DENV-2) DNA vaccine candidates were evaluated for their immunogenicity, homologous and heterologous neutralizing (Nt) antibody titers, and cross-genotype protection in a murine model. The immunity elicited by our prototype vaccine candidate (Asian 1 genotype strain 16681) in mice was protective against viruses of other genotypes but not against virus of the Sylvatic genotype, whose emergence and potential risk after introduction into the human population have previously been demonstrated. The underlying mechanism of a lack of protection elicited by the prototype vaccine may at least be contributed by the absence of a flavivirus subgroup-cross-reactive, highly neutralizing monoclonal antibody 1B7-5-like epitope in DENV-2 of the Sylvatic genotype. The DENV DNA vaccine directs the synthesis and assembly of virus-like particles (VLPs) and induces immune responses similar to those elicited by live-attenuated vaccines, and its flexibility permits the fast deployment of vaccine to combat emerging viruses, such as Sylvatic genotype viruses. The enhanced VLP secretion obtained by replacement of ectodomain I-II (EDI-II) of the Cosmopolitan genotype vaccine construct (VD2-Cosmopolitan) with the Asian 1 EDI-II elicited significantly higher total IgG and Nt antibody titers and suggests a novel approach to enhance the immunogenicity of the DNA vaccine. A DENV vaccine capable of eliciting protective immunity against viruses of existing and emerging genotypes should be the focus of future DENV vaccine development.
Life, Death, and Resurrection: Accounting for State Uncertainty in Survival Estimation from Tagged Grass Carp (2015)

Abstract Information about Grass Carp Ctenopharyngodon idella survival would be useful for improving the management of fish used for aquatic weed control. Reliable methods for estimating annual poststocking survival of Grass Carp from radiotelemetry data do not exist because the fish remain sedentary for prolonged periods between movements, giving the false impression of death, only to be observed alive (i.e., “resurrected”) at a later date. We constructed a state-space, multistate mark–recapture survival model accounting for uncertainty in the live/dead states of tagged Grass Carp in a large (8,500 ha) reservoir, and we estimated monthly and annual survival. Model results were compared with life history-based methods for estimating survival, and survival estimates that were corrected for state misclassification were compared with uncorrected estimates. Corrected estimates of annual survival (mean = 0.23; 95% credible interval [CRI] = 0.15–0.41) contained less bias than uncorrected estimates (0.12; 95% CRI = 0.08–0.18). However, both corrected and uncorrected estimates were substantially lower than the survival expected based on life history theory (mean = 0.69; 95% confidence interval = 0.52–0.78), suggesting that mark–recapture survival estimates for Grass Carp might be negatively biased due to tag shedding, tag-related mortality, or both. Our model effectively reduced bias in monthly and annual survival estimates due to state misclassification, illustrating the potential for application of existing mark–recapture frameworks to estimate Grass Carp survival with telemetry data, despite the behavioral idiosyncrasies of the species. Furthermore, these methods may have application for studies of other animals that undergo periodic quiescence between movements, such as salmonids, ictalurids, and reef fishes. To account for bias resulting from tag loss, future mark–recapture studies of Grass Carp could incorporate tag shedding rates within the framework developed here. Received July 19, 2014; accepted December 3, 2014
POS-503 EVALUATING CHRONIC KIDNEY DISEASE PROGRESSION: A REPORT FROM THE DISCOVER CKD RETROSPECTIVE COHORT (2021)

Rapid progression of chronic kidney disease (CKD) is associated with poor clinical outcomes. However, there is limited evidence on the epidemiology and characteristics of patients experiencing disease progression in a large multinational CKD population.
PSLotto: A Privacy-Enhanced COVID Lottery System (2022)

In March 2020, the World Health Organization (WHO) declared the novel coronavirus (COVID-19) a global pandemic. Globally the rapid spread of COVID-19 ground economies to a halt with stay at home orders and took the lives of millions of people. Therefore when vaccines became available as a tool to slow the spread of the COVID-19 virus, governments world-wide were looking to incentivize their populations to get vaccinated. Included in this effort, the government of Georgia created a lottery initiative to monetarily reward citizens who were vaccinated and encourage participation from those who were hesitant to get vaccinated. The Georgian lottery system that developed out of this initiative included a website displaying lottery winner data leading to serious privacy leakage. In this paper, we develop of an attack framework that allows adversaries with minimal background knowledge to re-identify STOPCOV Lottery winners and deploying our system against a subpopulation vulnerable to attack. We then propose our privacy-enhanced alternative, PSLotto, which simultaneously preserves the functionalities of the existing STOPCOV Lottery system and protects the privacy of lottery winners.
Supplement for Statistical Methods from Synergistic Antitumor Effects of Combined Epidermal Growth Factor Receptor and Vascular Endothelial Growth Factor Receptor-2 Targeted Therapy (2023)

Supplement for Statistical Methods from Synergistic Antitumor Effects of Combined Epidermal Growth Factor Receptor and Vascular Endothelial Growth Factor Receptor-2 Targeted Therapy
Reactions of lithio derivatives of carboxylic acids. 1. 3-Methyl-2-butenoic acids (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of lithio derivatives of carboxylic acids. 1. 3-Methyl-2-butenoic acidsParham William E. and David W. BoykinCite this: J. Org. Chem. 1977, 42, 2, 260–263Publication Date (Print):January 1, 1977Publication History Published online1 May 2002Published inissue 1 January 1977https://pubs.acs.org/doi/10.1021/jo00422a020https://doi.org/10.1021/jo00422a020research-articleACS PublicationsRequest reuse permissionsArticle Views237Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Chemically Exfoliated MoS2 as Near‐Infrared Photothermal Agents (2013)

Two-dimensional bio-dynamite: Chemically exfoliated MoS2 (ceMoS2), a water-dispersible sheet-like material, is an efficient near-infrared (NIR) photothermal transducer. The superior bio-supramolecular properties of ceMoS2 and the ability of this material to destroy biomolecular targets through near-infrared (NIR) photothermal transduction were studied (see picture).
Investigation of Direct Methanol Fuel Cell Electrocatalysts Using a Robust Combinatorial Technique (2005)

A combinatorial approach to batch fabricating and evaluating fuel cell catalyst surfaces is described. The well-known binary alloy and two compositional regimes of a novel quaternary system were examined in detail. Catalyst films no thicker than 10 nm were deposited onto an array of 36 gold electrodes in area that were microfabricated on a glass substrate. The catalyst films had identical bulk and surface compositions, a result of the atom-level mixing that occurred during the room-temperature cosputtering method used. A multichannel pseudopotentiostat was implemented for electrochemical screening. Compositions with promising and/or contrasting catalytic activities were also studied using X-ray diffraction, X-ray energy-dispersive spectroscopy, and X-ray photoelectron spectroscopy. A low-Pt-content film was found to exhibit nominally the same activity (at vs a normal hydrogen electrode in , ) as the best PtRu alloys studied. This material had a fundamentally different crystal and electronic structure than that observed in the films and exhibited a significantly higher degree of Pt site utilization. These results were consistent with the existence of a catalytic reaction pathway different than that reported for .
Simultaneous Analysis of Polymethoxyflavones and Flavanone Glycosides in Citrus Fruits by Micellar Electrokinetic Chromatography Using Sodium Deoxycholate (2014)

A method using micellar electrokinetic chromatography (MEKC) was developed for simultaneous determination of flavonoids in citrus fruits, which mainly consist of polymethoxyflavones (PMFs) and flavanone glycosides (FGs). Because there are significant differences in the magnitude of polarity between PMFs and FGs, it was difficult to optimize the conditions of MEKC using sodium dodecyl sulfate (SDS) for proper separation of both PMGs and FGs simultaneously. This was also found to be the case when an organic modifier such as dimethylsulfoxide (DMSO) was added to the running solutions. Simultaneous MEKC separation of PMGs and FGs was achieved by using sodium deoxycholate (SDC) in the presence of DMSO because of the relatively small difference in free energy to transfer from bulk solutions to the SDC micelle between PMFs and FGs. Fourteen flavonoids consisting of 4 flavanones, including three FGs and 10 flavones, including nine PMFs,were separated nearly completely using 10 mM phosphate buffer (pH 7.2), 75 mM SDC, 20% DMSO, and 10% acetonitrile as a running solution for MEKC. Additionally, we proposed a novel index that is an alternative to migration time and corrects variation of migration times in measurements successfully. Some of the flavonoids in fruits such as flat lemon and ponkan orange were identified with the help of this index. Further, fruit rind samples of ponkan oranges were taken monthly from a single tree from July to December and were analyzed for changes in content of four flavonoids.
Data from A Phase II, Prospective, Randomized, Multicenter, Open-Label Study of GX-188E, an HPV DNA Vaccine, in Patients with Cervical Intraepithelial Neoplasia 3 (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;To determine the efficacy of the therapeutic DNA vaccine GX-188E for inducing regression of cervical intraepithelial neoplasia (CIN) 3.&lt;/p&gt;Patients and Methods:&lt;p&gt;We conducted a prospective, randomized, multicenter, open-label, phase II clinical trial of GX-188E in CIN3 patients positive for human papillomavirus (HPV) type 16/18. The primary endpoint was to determine the histopathologic regression to ≤CIN1 at visit seven (V7; 20 weeks after the first GX-188E injection), and an extension study was pursued until visit 8 (V8; 36 weeks after the first GX-188E injection). HPV-sequencing analysis and an &lt;i&gt;ex vivo&lt;/i&gt; IFNγ ELISpot assay were performed using the collected cervical biopsy and blood samples from patients.&lt;/p&gt;Results:&lt;p&gt;In total, 72 patients were enrolled and underwent randomization. Of them, 64 patients were included in per-protocol analysis (V7) and 52 in extension analysis (V8). Our data showed 52% (33/64) of patients at V7 and 67% (35/52) of patients at V8 presented histopathologic regression after receiving the GX-188E injection. We found that 73% (V7) and 77% (V8) of the patients with histologic regression showed HPV clearance. HPV clearance and histopathologic regression were significantly associated at V7 and at V8. Compared with the measurements at V1 (baseline), the patients at V8 with HPV clearance showed significantly higher fold changes in their IFNγ ELISpot responses compared with those without HPV clearance. The HPV sequence analysis revealed that the HPV type 16 E6/E7 variants D25E, V83L, and N29S were inversely associated with histopathologic regression at V8.&lt;/p&gt;Conclusions:&lt;p&gt;GX-188E is an effective therapeutic vaccine against a cohort containing only CIN3 patients.&lt;/p&gt;&lt;/div&gt;