gebhart/patrepeval huggingface dataset:
Cell Death: Tipping the Balance of Autoimmunity and Tissue Repair (2008)

Inflammation is a key homeostatic process elicited by microbial components and by tissue damage. Increasing evidence indicates that the outcomes either tissue repair or persistent inflammatory damage and degeneration tightly depend on the pattern of cell death in situ and on infiltrating leukocytes and antigen presenting cells. Defects in the initiation and execution steps of programmed cell death such as in the clearance of cell debris are indeed often associated to inflammation defective repair and autoimmunity. Here we report recent developments on the control of apoptosis induction and execution discussing how cell death may be exploited for therapeutic purposes and the links between cell death persisting inflammation and stem cell recruitment and activation in experimental models of complex human diseases such as muscular dystrophy and cancer.
Vibrationally Resolved Fluorescence from Organic Molecules near Metal Surfaces in a Scanning Tunneling Microscope (2004)

Intrinsic molecular fluorescence from porphyrin molecules on Au(100) has been realized by using a nanoscale multimonolayer decoupling approach with nanoprobe excitation in the tunneling regime. The molecular origin of luminescence is established by the observed well-defined vibrationally resolved fluorescence spectra. The molecules fluoresce at low "turn-on" voltages for both bias polarities, suggesting an excitation mechanism via hot electron injection from either tip or substrate. The excited molecules decay radiatively through Franck-Condon pi(*)-pi transitions.
CORRIGENDUM: Addition of data source: Diagnostic model for pancreatic cancer using a multi-biomarker panel (2021)

[This corrects the article on p. 144 in vol. 100, PMID: 33748028.].
An Efficient Fluorescence Sensor for Superoxide with an Acridinium Ion-Linked Porphyrin Triad (2011)

Addition of potassium superoxide with 18-crown-6 ether (KO(2)(•-)-18-crown-6) to a toluene solution of an acridinium ion-linked porphyrin triad (Acr(+)-H(2)P-Acr(+)) resulted in a remarkable enhancement of the fluorescence intensity. Thus, Acr(+)-H(2)P-Acr(+) acts as an efficient fluorescence sensor for superoxide. Electron transfer from KO(2)(•-)-18-crown-6 to the Acr(+) moiety to produce the two-electron-reduced species (Acr(•)-H(2)P-Acr(•)) results in inhibition of the fluorescence quenching via photoinduced electron transfer, as revealed by laser flash photolysis measurements.
Exchange Reactions between Albumin-Au(I)-PEt3 Complex and Me3PAuCl or iPr3PAuCl: 31P NMR Spectroscopic Studies (2004)

Article Exchange Reactions between Albumin-Au(I)-PEt3 Complex and Me3PAuCl or iPr3PAuCl: 31P NMR Spectroscopic Studies was published on August 1, 2004 in the journal BioInorganic Reaction Mechanisms (volume 5, issue 2).
Quantitatively Mapping Localized Surface Plasmons with Sub-10-nm Resolution (2010)

International audience
Dynamic Packet Scheduling for Traffic Mixes of Best Effort and VoIP Users in E-UTRAN Downlink (2010)

This paper deals with packet scheduling for Voiceover-IP (VoIP) traffic in the Long Term Evolution (LTE) EUTRAN Downlink. The more specific target is to optimize the performance of dynamic scheduling for traffic mixes of VoIP and best effort users. To this end, we introduce the Required Activity Detection (RAD) packet scheduling algorithm with Delay Sensitivity (RAD-DS).With an appropriate delay sensitivity function, it is shown that a MACRO 1 cell with 5MHz transmission bandwidth can support up to 346 VoIP users. Furthermore, a novel delay sensitivity based soft prioritizing strategy is proposed for handling traffic mixes. It is shown that when 200 VoIP users are present in a cell along with best effort users, the proposed strategy can provide a cell throughput of up to 82% of the cell throughput with only best effort users.
Introspective Minds: Using ALE Meta-Analyses to Study Commonalities in the Neural Correlates of Emotional Processing, Social & Unconstrained Cognition (2012)

Previous research suggests overlap between brain regions that show task-induced deactivations and those activated during the performance of social-cognitive tasks. Here, we present results of quantitative meta-analyses of neuroimaging studies, which confirm a statistical convergence in the neural correlates of social and resting state cognition. Based on the idea that both social and unconstrained cognition might be characterized by introspective processes, which are also thought to be highly relevant for emotional experiences, a third meta-analysis was performed investigating studies on emotional processing. By using conjunction analyses across all three sets of studies, we can demonstrate significant overlap of task-related signal change in dorso-medial prefrontal and medial parietal cortex, brain regions that have, indeed, recently been linked to introspective abilities. Our findings, therefore, provide evidence for the existence of a core neural network, which shows task-related signal change during socio-emotional tasks and during resting states.
A robust self-calibrating transmission scheme for on-chip networks (2004)

Systems-on-Chip (SoC) design involves several challenges, stemming from the extreme miniaturization of the physical features and from the large number of devices and wires on a chip. Since most SoCs are used within embedded systems, specific concerns are increasingly related to correct, reliable, and robust operation. We believe that in the future most SoCs will be assembled by using large-scale macro-cells and interconnected by means of on-chip networks. We examine some physical properties of on-chip interconnect busses, with the goal of achieving fast, reliable, and low-energy communication. These objectives are reached by dynamically scaling down the voltage swing, while ensuring data integrity-in spite of the decreased signal to noise ratio-by means of encoding and retransmission schemes. In particular, we describe a closed-loop voltage swing controller that samples the error retransmission rate to determine the operational voltage swing. We present a control policy which achieves our goals with minimal complexity; such simplicity is demonstrated by implementing the policy in a synthesizable controller. Such a controller is an embodiment of a self-calibrating circuit that compensates for significant manufacturing parameter deviations and environmental variations. Experimental results show that energy savings amount up to 42%, while at the same time meeting performance requirements.
End-to-end compensation of digital-optical imaging systems (2006)

Reliable fabrication and assembly of high-quality electro-optical imaging systems is a critical challenge facing electro-optical imaging system manufacturers. Optical compensation is one standard approach for minimizing the effects of errors introduced during the manufacture and construction of the optical subsystems. We describe how digital image processing should be considered as a form of compensation when evaluating a complete imaging system. We describe a novel method for digital-optical compensation which jointly adjusts both optical parameters and image processing parameters to maximize end-to-end imaging performance. We verify the superiority of this joint compensation strategy over the traditional sequential compensation through several example imaging systems.
Entrepreneurship and pure altruism: Reconciling the irreconcilable? Evidence from a New Zealand mail-order firm (2007)

Abstract This article examines the existence of altruism in the formation of a firm and argues that altruism can coexist with the most demanding form of capitalism: Schumpeterian creative destruction. Moreover, pure altruism is seen to be a precursor to the accumulation of capital, not an event ex post. Such a notion suggests a re-examination of views of altruistic behaviour wherein altruism is reduced purely to variant forms of self-interest and reciprocity.
Infections, atherosclerosis, and coronary heart disease (2017)

Atherosclerosis is a chronic inflammatory disease. Pathophysiological similarities between chronic infections and atherosclerosis triggered interest in a clinical association between these conditions. Various infectious microbes have been linked to atherosclerotic vascular disease in epidemiological studies. However, this association failed to satisfy the Koch's postulates of causation with multiple clinical trials demonstrating inefficacy of anti-infective therapies in mitigating atherosclerotic cardiovascular events. Identification of underlying pathophysiological mechanisms and experience with vaccination against various infectious agents has ushered a new avenue of efforts in the development of an anti-atherosclerotic vaccine. Studies in animal models have identified various innate and adaptive immune pathways in atherosclerosis. In this review, we discuss the patho-biological link between chronic infections and atherosclerosis, evaluate existing evidence of animal and human trials on the association between infections and cardiovascular disease and introduce the concept of an anti-atherosclerotic vaccine.
Essai accéléré de durabilité du collage blanc sur noir dans une chaussée composite (2005)

17ème Congrès Français de Mécanique, TROYES, FRANCE, 29-/08/2005 - 02/09/2005
Silicon p-n junctions biased above breakdown used as monitors of carrier lifetime (2000)

In this paper we show that single-photon avalanche detectors (SPADs) may have a strong potential as very sensitive on-wafer tools for lifetime monitoring, given their simple fabrication process and their straightforward use in the measurements. We have fabricated Si SPADs with n+-p structures and we show that dark counting has a simple exponential dependence on time, thus making it possible to extract a single lifetime parameter.
Search for lepton flavour violating decays of the Higgs boson to μτ and eτ in proton-proton collisions at $$ \sqrt{s}=13 $$ TeV (2018)

A bstract A search for lepton flavour violating decays of the Higgs boson in the μτ and e τ decay modes is presented. The search is based on a data set corresponding to an integrated luminosity of 35.9 fb −1 of proton-proton collisions collected with the CMS detector in 2016, at a centre-of-mass energy of 13 TeV. No significant excess over the standard model expectation is observed. The observed (expected) upper limits on the lepton flavour violating branching fractions of the Higgs boson are ℬ(H → μτ ) &lt; 0.25% (0.25%) and ℬ(H → e τ ) &lt; 0.61% (0.37%), at 95% confidence level. These results are used to derive upper limits on the off-diagonal μτ and e τ Yukawa couplings $$ \sqrt{{\left|{Y}_{\mu \tau}\right|}^2+{\left|{Y}_{\tau \mu}\right|}^2}&lt;1.43\times {10}^{-3} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msqrt> <mml:mrow> <mml:msup> <mml:mfenced> <mml:msub> <mml:mi>Y</mml:mi> <mml:mrow> <mml:mi>μ</mml:mi> <mml:mi>τ</mml:mi> </mml:mrow> </mml:msub> </mml:mfenced> <mml:mn>2</mml:mn> </mml:msup> <mml:mo>+</mml:mo> <mml:msup> <mml:mfenced> <mml:msub> <mml:mi>Y</mml:mi> <mml:mrow> <mml:mi>τ</mml:mi> <mml:mi>μ</mml:mi> </mml:mrow> </mml:msub> </mml:mfenced> <mml:mn>2</mml:mn> </mml:msup> </mml:mrow> </mml:msqrt> <mml:mo>&lt;</mml:mo> <mml:mn>1.43</mml:mn> <mml:mo>×</mml:mo> <mml:msup> <mml:mn>10</mml:mn> <mml:mrow> <mml:mo>−</mml:mo> <mml:mn>3</mml:mn> </mml:mrow> </mml:msup> </mml:math> and $$ \sqrt{{\left|{Y}_{\mathrm{e}\tau}\right|}^2+{\left|{Y}_{\tau \mathrm{e}}\right|}^2}&lt;2.26\times {10}^{-3} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msqrt> <mml:mrow> <mml:msup> <mml:mfenced> <mml:msub> <mml:mi>Y</mml:mi> <mml:mrow> <mml:mi>e</mml:mi> <mml:mi>τ</mml:mi> </mml:mrow> </mml:msub> </mml:mfenced> <mml:mn>2</mml:mn> </mml:msup> <mml:mo>+</mml:mo> <mml:msup> <mml:mfenced> <mml:msub> <mml:mi>Y</mml:mi> <mml:mrow> <mml:mi>τ</mml:mi> <mml:mi>e</mml:mi> </mml:mrow> </mml:msub> </mml:mfenced> <mml:mn>2</mml:mn> </mml:msup> </mml:mrow> </mml:msqrt> <mml:mo>&lt;</mml:mo> <mml:mn>2.26</mml:mn> <mml:mo>×</mml:mo> <mml:msup> <mml:mn>10</mml:mn> <mml:mrow> <mml:mo>−</mml:mo> <mml:mn>3</mml:mn> </mml:mrow> </mml:msup> </mml:math> at 95% confidence level. The limits on the lepton flavour violating branching fractions of the Higgs boson and on the associated Yukawa couplings are the most stringent to date.
Identification of ataxia‐associated mtDNA mutations (m.4052T>C and m.9035T>C) and evaluation of their pathogenicity in transmitochondrial cybrids (2009)

The potential pathogenicity of two homoplasmic mtDNA point mutations, 9035T>C and 4452T>C, found in a family afflicted with maternally transmitted cognitive developmental delay, learning disability, and progressive ataxia was evaluated using transmitochondrial cybrids. We confirmed that the 4452T>C transition in tRNA(Met) represented a polymorphism; however, 9035T>C conversion in the ATP6 gene was responsible for a defective F(0)-ATPase. Accordingly, mutant cybrids had a reduced oligomycin-sensitive ATP hydrolyzing activity. They had less than half of the steady-state content of ATP and nearly an 8-fold higher basal level of reactive oxygen species (ROS). Mutant cybrids were unable to cope with additional insults, i.e., glucose deprivation or tertiary-butyl hydroperoxide, and they succumbed to either apoptotic or necrotic cell death. Both of these outcomes were prevented by the antioxidants CoQ(10) and vitamin E, suggesting that the abnormally high levels of ROS were the triggers of cell death. In conclusion, the principal metabolic defects, i.e., energy deficiency and ROS burden, resulted from the 9035T>C mutation and could be responsible for the development of clinical symptoms in this family. Furthermore, antioxidant therapy might prove helpful in the management of this disease.
Development and Pre-Clinical Evaluation of a Novel Prostate-Restricted Replication Competent Adenovirus-AD-IU-1 (2004)

Abstract : Recently we generated a prostate specific chemic promoter, called PSES, by combining the active prostate specific enhancers from prostate specific antigen (PSA) and prostate specific membrane antigen (PSMA) genes which are prominently expressed in androgen independent (AI) prostate cancers. The goal of this research is to develop a novel therapeutic agent, Ad-IU-1, using PSES to control the replication of adenovirus and the expression of a therapeutic gene, herpes simplex thymidine kinase (TK). AD-IU-1 replicates as efficient as a wild type adenovirus in PSA/PSMA positive cells, but not in PSA/PSMA negative cells. Prodrug GCV augmented Ad-IU-1's killing activity against PSA/PSMA positive cells, but not PSA/PSMA negative cells in vitro. Ad-IU-1 was more effective in inhibit the growth of androgen-independent CWR22rv tumors. Due to recent improvement in our adenoviral vector construction which allows us to insert a bigger transgene into the viral genome, we further investigated a fusing suicide gene, FCYttk, by combining two suicide genes, a yeast cytosine deaminase, FCY, and improved TK, ttk. FCYttk had a better killing activity than TK against prostate cancer cells. We have constructed and investigated a FCYttk-armed prostate restricted replicative adenovirus for future clinical investigation.
Acretoside, a new sucrose ester fromAristolochia cretica (2005)

A new sucrose ester, acretoside, was isolated from the roots of the Greek endemic species Aristolochia cretica and identified as 6-O-p-coumaroyl-beta-D-fructofuranosyl-(2 --> 1)-alpha-D-glucopyranoside (1). In addition, a known sucrose ester, identified as arillatose B, two phenylpropanoid glucose esters, and five derivatives of aristolochic acid were isolated. Their structures were elucidated on the basis of MS and NMR data.
Section Review: Central & Peripheral Nervous Systems: Corticotropin releasing factor and Alzheimer's disease: recent developments with implications for more effective therapies (1996)

Alzheimer's disease (AD) is a progressive degenerative disease of the nervous system characterised neuropathologically by the presence of senile plaques and neurofibrillary tangles in amygdala, hippocampus and neocortex [1,2]. Dysfunction and death of basal cholinergic neurones projecting to forebrain targets are associated with marked decreases in cholinergic markers, including the activity of choline acetyl transferase [3]. Although cerebral cortical levels of somatostatin and somatostatin receptors have been reported to be reduced in AD, no consistent changes have been reported in other neuropeptide systems [4,5]. Here we review the current understanding of the role of corticotropin releasing factor (CRF) in AD and discuss the possibilities of exploiting this neuropeptide system for a molecular therapy to treat AD.
Lipocortins 1 and 2 as substrates for the insulin receptor kinase in rat liver. (1988)

Lipocortins 1 and 2 are major substrates for the epidermal growth factor receptor and the pp60v-src tyrosine kinases in transformed cells. In the present study, we have characterized the phosphorylation of lipocortins 1 and 2 by the insulin receptor tyrosine kinase in vitro and in vivo. In vitro, the solubilized insulin receptor, partially purified from rat liver, catalyzed phosphorylation of human recombinant lipocortin 1 and purified bovine lipocortin 2. Phosphorylation of lipocortin 1 was increased 15-fold upon stimulation with 10(-7) M insulin. The apparent Km of the reaction was 3.3 microM and was not affected by insulin stimulation. Insulin stimulated phosphate incorporation into lipocortin 2 by 20-fold (apparent Km greater than 20 microM). Both lipocortins were phosphorylated exclusively on tyrosine residues as judged by phosphoamino acid analysis. Based upon peptide mapping, lipocortin 1 was phosphorylated on Tyr-21, a site phosphorylated by other tyrosine kinases. Polyclonal anti-phosphotyrosine antibodies recognized the tyrosine-phosphorylated lipocortin 2, but not lipocortin 1 in its phosphorylated form. In hepatocytes from normal and dexamethasone-treated rats, lipocortin 1 content was less than 50 ng/10(6) cells. Insulin-induced phosphorylation of lipocortin 1 was detected in intact hepatocytes from corticosteroid-treated animals but not in cells from normal rats. No phosphorylation of lipocortin 2 was found, although its content was approximately 100 ng/10(6) cells from normal animals and increased to approximately 1 microgram/10(6) cells following treatment of rats with dexamethasone for 4 days. Thus, although lipocortins 1 and 2 are in vitro substrates of the insulin receptor kinase, only lipocortin 1 is phosphorylated in an insulin-dependent manner in intact hepatocytes, and this is only observed after dexamethasone treatment of the rats.
Indomethacin treatment of recurrent nephrotic syndrome and focal segmental glomerulosclerosis after renal transplantation (1993)

Indomethacin treatment of recurrent nephrotic syndrome and focal segmental glomerulosclerosis after renal transplantation Get access M. F. Kooijmans-Coutinho, M. F. Kooijmans-Coutinho 1Dept. of Nephrology, Leiden University HospitalLeiden, The Netherlands Correspondence and offprint requests to: Mrs M. F. Kooijmans-Coutinho, University Hospital Leiden, Department of Nephrology, Building 1, C3-P, PO Box 9600, 2300 RC Leiden, The Netherlands Search for other works by this author on: Oxford Academic PubMed Google Scholar A. M. Tegzess, A. M. Tegzess 2Dept. of Nephrology, Groningen University HospitalGroningen Search for other works by this author on: Oxford Academic PubMed Google Scholar J. A. Bruijn, J. A. Bruijn 3Dept. of Pathology, Leiden University HospitalLeiden, The Netherlands Search for other works by this author on: Oxford Academic PubMed Google Scholar K. W. Florijn, K. W. Florijn 1Dept. of Nephrology, Leiden University HospitalLeiden, The Netherlands Search for other works by this author on: Oxford Academic PubMed Google Scholar L. A. van Es, L. A. van Es 1Dept. of Nephrology, Leiden University HospitalLeiden, The Netherlands Search for other works by this author on: Oxford Academic PubMed Google Scholar F. J. van der Woude F. J. van der Woude 1Dept. of Nephrology, Leiden University HospitalLeiden, The Netherlands Search for other works by this author on: Oxford Academic PubMed Google Scholar Nephrology Dialysis Transplantation, Volume 8, Issue 5, 1993, Pages 469–473, https://doi.org/10.1093/oxfordjournals.ndt.a092506 Published: 01 January 1993 Article history Received: 17 June 1992 Accepted: 26 November 1992 Published: 01 January 1993
Data acquisition system for MAET with magnetic field measurements (2019)

Magneto-acousto-electrical tomography (MAET) is an imaging modality to image the electrical conductivity of biological tissues. It is based on electrical current induction by using ultrasound under a static magnetic field. The aim of this study is to develop a data acquisition system for MAET based on magnetic field measurements. The static magnetic field is generated by six permanent neodymium magnets. A 16-element linear phased array (LPA) transducer is utilized to generate acoustic pressure waves inside the phantom. To measure the magnetic field intensity generated by the induced currents, contactless receiver sensors are developed using two similar disk multiple layer coils, which are Helmholtz coil sensor. Physical properties and electrical characteristics of the sensors are assessed. A two-stage cascaded amplifier is designed and utilized in the receiving system. The gain of the cascaded amplifier at 1 MHz is adjusted to be 96 dB. Experimental studies are conducted with two different phantoms, having 3 S m<sup>-1</sup> and 58 S m<sup>-1</sup> electrical conductivity, respectively. A-scan and B-scan images of phantoms are obtained with the LPA transducer. Comparison of the ultrasound (A-scan) and MAET signals reveals that 3 S m<sup>-1</sup> conductive inhomogeneity can be detected with this data acquisition system. Furthermore, the front and rear interfaces of an inhomogeneity ([Formula: see text]) of 58 S m<sup>-1</sup> conductivity are detectable.
Growth of a Strictly Anaerobic Bacterium on Furfural (2-Furaldehyde) (1983)

A strictly anaerobic bacterium was isolated from a continuous fermentor culture which converted the organic constituents of sulfite evaporator condensate to methane and carbon dioxide. Furfural is one of the major components of this condensate. This furfural isolate could degrade furfural as the sole source of carbon and energy in a defined mineral-vitamin-sulfate medium. Acetic acid was the major fermentation product. This organism could also use ethanol, lactate, pyruvate, or fumarate and contained cytochrome c(3) and desulfoviridin. Except for furfural degradation, the characteristics of the furfural isolate were remarkably similar to those of the sulfate reducer Desulfovibrio gigas. The furfural isolate has been tentatively identified as Desulfovibrio sp. strain F-1.
Analysis of Coupling Effects on Overhead VSC-HVDC Transmission Lines From AC Lines With Shared Right of Way (2010)

The coupling of fundamental frequency voltages and currents on voltage-source converter (VSC)-HVDC overhead transmission lines from neighboring ac lines is analyzed. The complementary modulation components at dc and second harmonic frequencies on the ac side of the converter resulting from the fundamental frequency coupling are analyzed. A mathematical model is developed for the VSC converter that accurately represents modulation effects to and from its ac and dc sides. This model is shown to be significantly different from that of a conventional line-commutated converter. This model is validated by using electromagnetic transients simulation. The model is then combined with an accurate frequency-domain model of the transmission lines and the converter ac-side equipment, and used to conduct parametric analysis of the coupling effects. As the induced 0-Hz (dc) modulation component on the ac side is of serious concern, parametric plots are presented showing its variation with factors, such as ac/dc separation distance, paralleled length, transposition and VSC operating point.