gebhart/patrepeval huggingface dataset:
Tetracycline Encapsulated in Au Nanoparticle-Decorated ZnO Nanohybrids for Enhanced Antibacterial Activity (2022)

Bacterial infections instigated by antibiotic-resistant bacteria are considered perilous health threats in today’s world due to their fast-increasing nature and the fewer availability of new treatment strategies. The properties of nanomaterials triggered by external stimuli are considered an encouraging technique for the remediation of antibacterial infectious diseases by producing photoinduced reactive oxygen species (ROS). Light-mediated treatment using zinc oxide (ZnO)-based nanohybrids leads the field with high interest in terms of sensitization of antibiotics and their targeted delivery. Moreover, the dual sensitization in a hybrid system could produce more efficacy as this phenomenon has been implemented in dye sensitized solar cells and photocatalysis. However, most of those hybrids are complicated and non-biocompatible. The present study highlights a tri-hybrid by encapsulating tetracycline (TC) in Au nanoparticle-decorated ZnO nanoparticles. The composition and morphology of the samples were characterized by electron microscopy, ultrafast optical spectroscopy, and density functional theory-based techniques. The dual sensitization in the tri-hybrids leads to enhanced antimicrobial activity against Gram-positive Staphylococcus hominis bacteria due to immense ROS under white light irradiation. The Förster resonance energy transfer from TC to Au and the excited-state photo-electron transfer process in the Au_ZnO-TC tri-hybrid system trigger a huge charge separation, which enhances production of ROS. Due to such a huge ROS production capability, the tri-hybrid shows a significant antibacterial action. Moreover, the Au nanoparticle-decorated ZnO is capable of destroying excess antibiotics, which potentially reduces the chance of development of antibiotic resistance. Overall, the study demonstrates a promising aspect that could be beneficial for manifold biological applications.
Oxygen Permeation Properties of Partially A-Site Substituted BaFeO[sub 3−δ] Perovskites (2009)

To explore oxygen permeable materials, oxygen permeation properties of partially A-site substituted perovskites were investigated. Ba sites in were substituted with cations such as Na, Rb, Ca, Y, and La by 5%. The partial substitution with Ca, Y, and La, whose ionic radii are smaller than that of Ba, succeeded in stabilizing a cubic perovskite structure that is a highly oxygen permeable phase, as revealed by X-ray diffraction analysis. This can be explained in terms of a decrease in the tolerance factor . Among the (M = Na, Rb, Ca, Y, and La) membranes tested, showed the highest oxygen permeability at 600–930°C, owing to the stabilization of the cubic phase without the formation of impurity phases. From chemical analysis, the oxygen permeability of membranes was correlated with the amount of oxygen defects (δ) in the lattice. The oxygen permeation flux of membrane was significantly increased by reducing its thickness. Furthermore, a membrane exhibited good phase stability under He flow at elevated temperatures. The obtained results indicate the promising properties of membranes as a cobalt-free material that has a high oxygen permeability, good phase stability, and low cost.
Water soluble polymeric nanogels by xanthate-mediated radical crosslinking copolymerisation (2006)

Branched water-soluble copolymers were obtained by direct radical crosslinking copolymerisation of acrylic acid or acrylamide and N,N'-methylenebisacrylamide at high solid content in the presence of an O-ethylxanthate as a reversible chain transfer agent.
Protein Structure Dynamic Prediction: a Machine Learning/Molecular Dynamic Approach to Investigate the Protein Conformational Sampling (2021)

Abstract Proteins exist in several different conformations. These structural changes are often associated with fluctuations at the residue level. Recent findings show that co-evolutionary analysis coupled with machine-learning techniques improves the precision by providing quantitative distance predictions between pairs of residues. The predicted statistical distance distribution from Multi Sequence Analysis (MSA) reveals the presence of different local maxima suggesting the flexibility of key residue pairs. Here we investigate the ability of the residue-residue distance prediction to provide insights into the protein conformational ensemble. We combine deep learning approaches with mechanistic modeling to a set of proteins that experimentally showed conformational changes. The predicted protein models were filtered based on energy scores, RMSD clustering, and the centroids selected as the lowest energy structure per cluster. The models were compared to the experimental-Molecular Dynamics (MD) relaxed structure by analyzing the backbone residue torsional distribution and the sidechain orientations. Our pipeline not only allows us to retrieve the global experimental folding but also the experimental structural dynamics. We show the potential correlation between the experimental structure dynamics and the predicted model ensemble demonstrating the susceptibility of the current state-of-the-art methods in protein folding and dynamics prediction and pointing out the areas of improvement.
Visceral metastases on abiraterone vs. placebo: A post-hoc analysis of mode of radiographic progression in COU-AA-302. (2018)

194 Background: Abiraterone prolongs survival in patients with prostate cancer due to its potent inhibition of androgen synthesis. We previously observed increased rates of visceral metastatic disease at the time of progression on abiraterone compared to baseline, a poor prognostic feature associated with non-AR dependent prostate cancer. We hypothesized that the rate of development of visceral disease was increased with abiraterone compared to other treatments without potent androgen signaling inhibition. In order to test this, we examined time to visceral disease among patients treated with abiraterone vs placebo on the COU-AA-302 trial. Methods: We performed a post-hoc analysis of radiographic progression data for the phase 3 study of abiraterone vs placebo, via a data sharing agreement through the Yale Open Data Access Project. Data were censored at end of study treatment. The distribution of cumulative incidence for visceral metastases was calculated by the Kaplan-Meier method and compared with log-rank testing. Multivariable cox regression analysis was performed to assess for independent association of study treatment (abiraterone vs placebo) with the development of visceral metastases. Results: Median follow-up was 12.5mo, and 84 of 1088 patients developed visceral metastases. Univariate log-rank testing showed no difference in time to visceral metastasis between groups (p = 0.97). 1- and 3-yr cumulative incidence of visceral metastases were estimated at 6.4% and 15.6% for abiraterone and 4.6% and 17.0% for placebo, respectively. Study treatment was not a significant predictor for the development of visceral metastasis (HR 0.76; 95% CI 0.47-1.21) after adjustment for baseline metastatic disease burden (soft tissue and bone) and LDH. Conclusions: Abiraterone was not associated with increased visceral metastases at progression compared to placebo. These data give more confidence to oncologists that abiraterone is not driving prostate cancer to an aggressive phenotype characterized by visceral metastases - a finding that is particularly important as abiraterone is increasingly used in early disease states.
Falls and comorbid conditions among community dwelling Arkansas older adults from a population-based survey. (2014)

The prevalence of self-reported falls and associated comorbid conditions among community dwelling Arkansas older adults (ages 65 years and older) was estimated using data from the 2010 Behavioral Risk Factor Surveillance System survey. 1,653 Arkansas older adults were surveyed. Eighteen percent of them had sustained a fall at least once in the past three months prior to the survey period. After adjusting for age, general health, coronary heart disease, diabetes status and quality rest or sleep in a multinomial logistic regression, we found that older adults with visual impairment (OR = 1.47; 95% CI: 1.02, 2.12), and those who use special equipment (OR = 2.85; 95% CI: 1.94, 4.19) were more likely to have sustained a fall. An integrated multidisciplinary approach in caring for older adults is imperative for preventing falls and fall-related injuries. This can also reduce-fall-related hospitalizations and potentially result in substantial cost savings as well as improve the quality of life of older Arkansans.
ChemInform Abstract: Inhibitors of Cholesterol Biosynthesis. Part 1. 3,5‐Dihydroxy‐7‐(N‐ imidazolyl)‐6‐heptenoates and ‐heptanoates, a Novel Series of HMG‐CoA Reductase Inhibitors. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Molecular detection and characterization of clonal cell populations in acute lymphocytic leukemia by analysis of conformational polymorphisms of cRNA molecules of rearranged T-cell-receptor-gamma and immunoglobulin heavy-chain genes. (1994)

Junctional regions of rearranged T-cell-receptor-gamma (TCR) and immunoglobulin heavy-chain (IgH) genes represent an idiotypic DNA sequence for an individual lymphocytic cell, and any clone or clonal disease developing from this cell. In this study, a novel methodology for detection and characterization of clone specific DNA sequences in patients with acute lymphocytic leukemia (ALL) was developed. Junctional regions of rearranged TCR-gamma IgH genes in specimens of bone marrow aspirates of patients with ALL (precursor-B-ALL ten, T-ALL two, null-ALL one; ALL not classified one), of a patient with lymphoid blast crisis of chronic myeloid leukemia, of a B-cell chronic lymphocytic leukemia, and in DNA from peripheral blood mononuclear cells of ten healthy volunteers were amplified by polymerase chain reaction (PCR). The PCR products were transcribed into complementary RNA (cRNA). Conformational polymorphisms of cRNA molecules were analyzed by non-denaturing polyacrylamide gel electrophoresis. A specific cRNA banding pattern for rearranged TCR-gamma or IgH genes was observed in all patients with lymphocytic leukemia. In contrast, analysis of DNA from healthy volunteers yielded a smear of confluent polymorphisms representing multiple different cRNA molecules. In two patients with precursor-B-ALL, cRNA banding patterns of junctional regions of rearranged TCR-gamma genes were analyzed in sequential bone marrow aspirates. The banding patterns disappeared after chemotherapy and achievement of blast clearance. This novel and rapid molecular assay offers several advantages as compared to Southern blot analyses and previous PCR based methodologies for the detection of clonal lymphocytic populations. With this methodology, studies on the clonal evolution of lymphoproliferative disorders (e.g. the prognostic significance of the emergence of additional clones) can be performed more easily than with any other traditional molecular method.
MICRODROPLET EMULSION GENERATOR ARRAYS FOR HIGH- THROUGHPUT SINGLE CELL GENETIC VARIATION ANALYSIS (2010)

Single cell resolution technology enables the investigation of rare biological events masked by the ensemble average. We have developed a high-throughput microdroplet emulsion generator array (MEGA) as a core platform for massively parallel emulsion PCR-based detection of single cells with a frequency lower than 10
Errata to "A new heuristic diffraction coefficient for lossy dielectric wedges at normal incidence" (2002)

For the above-named work [ibid., vol. 1, pp. 165-168, 2002] in (1, Sec. III), there are two corrections to the text that are presented here.
Expression of human endogenous retroviruses and associated transcripts in Hodgkin lymphoma cells (2020)

Introduction During human evolution, germline infections by retroviruses have repeatedly occurred, integrating viral DNA into the host genome. As a result, the human genome consists of approximately 8% human endogenous retroviruses (HERV). Although most of this viral DNA is defective due to mutations, there are sequences with intact open reading frames for the generation of viral transcripts and proteins. In Hodgkin lymphoma (HL) the activation of HERV loci and expression of related transcripts has been observed.
Measurement accuracy and dependence on external influences of the iPhone X TrueDepth sensor (2019)

Depth sensors for three-dimensional object acquisition are widely used and available in many different sizes and weight classes. The measuring method used and the measuring accuracy depend on the task to be performed. The integration of depth sensors in mobile devices such as tablets and smartphones is largely new. The TrueDepth system of the iPhone X shows which measurement accuracies can be achieved with these systems and which areas of application can be achieved in addition to consumer fun. The investigations show that the TrueDepth system of the iPhone X can be used for measuring tasks with accuracies in the millimeter range.
25 Years of ISWC: Time Flies When You're Having Fun (2021)

Much has changed in the landscape of wearables research since the first International Symposium on Wearable Computers (ISWC) was organized in 1997. The authors, many of whom were active in this community since the beginning, reflect now 25 years later on the role of the conference, emerging research methods, the devices, and ideas that have stood the test of time—such as fitness/health sensors or augmented reality devices—as well as the ones that can be expected still to come, like everyday head-worn displays.
Software Platformization of Object Handling Robot with ROS (2021)

We have built an intelligent robot reference architecture with ROS. Using this architecture as a platform, the development efficiency of picking robots and unloading robots has improved. The modularization and core assetization of robot functions have made it easy to add or change functions and reuse software in the future. In addition, the platform based on ROS has made it possible to easily incorporate open technologies through open innovation.
<title>Superanamorphic backlighting remote imaging display (SABRID)</title> (2000)

The Super-Anamorphic Backlighting Remote Imaging Display (SABRID) collimating system is the purpose of this paper. The SABRID transforms point light source into collimated (plane) beam. In contrast to common bulky axial-symmetry lens collimator, the highly compact SABRID has three (3) axes of symmetry. The SABRID is attractive for many civilian and military applications, when compactness and/or separation of source light power (up to 20 m) from display itself is essential for safety packaging and other purposes.
Rapid, High-Yield, Solid-Phase Synthesis of the Antitumor Antibiotic Sansalvamide A Using a Side-Chain-Tethered Phenylalanine Building Block (2000)

A 10-step solid-phase synthesis of the cytotoxic depsipeptide sansalvamide A (1) has been accomplished in an overall yield of 67% with >95% purity employing polymer-bound phenylalanine building block 2. Both the N- and C-termini of 2 are extended followed by on-resin head-to-tail macrocyclization of the linear peptide in a high yield. This should be a general stategy for the synthesis of diverse libraries of cyclic peptides and depsipeptides that contain exclusively phenylalanine and other hydrophobic side chains.
Abstract 787: Differences in protein expression patterns in lung adenocarcinomas arising in never versus ever smokers (2010)

Abstract Background. Approximately 25% of lung cancer cases worldwide, mostly adenocarcinomas, are not attributable to tobacco use. Despite that some striking differences have been identified in the epidemiological, clinical and molecular characteristics of lung cancer arising in never smokers versus smokers, our current knowledge of lung adenocarcinoma in never smokers is still limited. Methods. We examined the immunohistohemical (IHC) expression of 101 proteins in surgically resected lung adenocarcinoma tissue microarray specimens obtained from 52 never smokers and compared the findings with 152 tumors obtained from ever smokers. The markers examined included a wide variety of tumor-related proteins, representing all hallmarks of cancer (Hanahan and Weinberg, Cell 2000). The IHC expression was assessed at cytoplasm [c], membrane [m], and nucleus [n] of malignant cells, and in stromal cells. Univariate and multivariate (adjusting by patients’ sex, and tumor stage and EGFR mutation status) statistical analyses were performed to assess the statistical differences in the expression of markers according to smoking status. The expression of the markers was correlated with patients’ clinical characteristics and tumors’ pathological features and EGFR mutational status. Results. In the multivariate analysis, tumors from smokers showed a relatively high number of markers (n=32) with significant higher expression compared with tumors from never smokers. Interestingly, in the univariate analysis, nine markers showed significantly higher expression in tumors from never smokers compared with ever smokers, including FGFR-1 [n], FGFR-2 [n], ER-alpha [n], CD44 [c], FOLR1 [m], IGFBP3 [n], IL-1alpha [c], NF-kB [n], survivin [n] and RGS17 [n]. In the multivariate analysis, six markers showed significantly higher expression in tumors from never smokers, including FGFR-2 [n] (P=0.018), CD44 [c] (P=0.001), c-Met [c] (P=0.045) and [m] (P=0.017), E-Cadherin [m] (P=0.003), IGFBP3 [n] (P=0.0009) and p-HER3 [m] (P=0.035). Twenty-nine markers showed significant association with EGFR mutations in tumors in the multivariate analysis adjusting by patients’ sex and smoking status, and tumor stage. Additionally, 47 markers showed significant differences in the level of expression comparing patients’ smoking status, including current, former and never smokers. Conclusion. Our findings indicate that there are multiple molecular differences between lung adenocarcinomas arising in never and ever smokers, suggesting that they are different entities. These findings have implications for the selection of molecular targets for developing novel therapy in patients with lung adenocarcinoma based on their smoking history (Supported by grant VITAL W81XWH-04-1-0142 and UT-Lung SPORE P50CA070907). Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 787.
Extreme Imaging Architectures (2014)

Optical imaging systems are constrained in spatial dimensions by both physical and practical issues. In this talk, we review some possible architectures that may allow future construction of extremely large, small, flat, narrow, and conformal imaging systems. In addition, the supporting technologies of laser engineering, lens design, and self-assembly will be explored.
The ubiquitin editing enzyme A20 (TNFAIP3) is upregulated during permanent middle cerebral artery occlusion but does not influence disease outcome (2013)

Cerebral ischemia is characterized by the activation of glial cells, causing a rapid and massive local inflammatory reaction that leads to tissue damage and neuronal cell death. 1 Over the past decade, it has become increasingly clear that the transcription factor nuclear factor kB (NF-kB) has a central role in the pathogenesis of cerebral ischemia. The NF-kB
Urinary Claudin-1 Level as a Marker of Podocyte Injury in Patients with Proteinuria (2020)

Abstract Background The biology of claudins is a rapidly evolving field, and many intriguing questions remain unanswered. Although it had been assumed that the reason there are ≥24 isoforms of claudin is that each one has distinct permeability properties. The nephron displays a wide spectrum of claudins, whose distribution varies in each tubular segment. In diabetic nephropathy and glomerulonephritis the gene expression of claudin-1, is markedly upregulated in the podocyte, accompanied by a tighter filtration slit diaphragm (cell-cell junction made by the glomerular podocytes) and the appearance of TJ-like structures between the foot processes causing further podocytes injury and proteinuria. Aim of the work to assess urinary claudin -1 level as a marker of podocyte injury in patients with proteinuria. Patients and Methods it is a case control study which was conducted upon 90 subjects who were divided into three groups: group I included 30 patients with type II DM, group II included 30 patients with glomerulonephritis and group III had 30 healthy subjects as controls. Urinary claudin-1 level was measured by Enzyme linked Immunosorbent Assay (ELISA) Results In this study, we found that urinary claudin-1 level was significantly higher in diabetics group and GN group than in control group. In comparison between GN group and diabetic group, we found that urinary claudin-1 level was higher in GN group than in diabetics group but with no statistically significant difference between the two groups. Conclusion urinary claudin-1 level was significantly higher in diabetics and GN group and has positive correlation with uACR. So it can be used as marker of podocytes injury and proteinuria
Improved Correlated Multiple Sampling by Using Interleaved Pixel Source Follower for High-Resolution and High-Framerate CMOS Image Sensor (2021)

This article describes an improvement in the noise reduction performance of a column correlated multiple sampling (CMS) readout circuit using interleaved pixel source follower for high-resolution and high-framerate CMOS image sensors (CISs). In this architecture, the time-interleaved operation of the two pixel source followers reduces the restrictions imposed by the settling time of the pixel source followers and extends the time for multiple sampling. The noise analysis indicates that this method has an advantage of enhanced noise reduction not only for thermal noise but also for 1/ f noise when a high-speed readout operation is required. The measurement of the noise performance of the 8K image sensor using the CMS with the interleaved pixel source follower method exhibits a low input-referred noise of 3.2 e <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-</sup> at 8K 120 frames per second, while 4.6 e <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-</sup> with the conventional single-source follower readout method. The measurement results match reasonably well with the analysis presented in this article, demonstrating the effectiveness of the interleaved pixel source follower method for high-resolution and high-framerate CISs.
An information system for material microstructures (2004)

This work presents an information system that supports a materialographic laboratory in class material samples based on microstructure images. The system uses database and Web technologies to manage its information and make it accessible to Internet users. Its core is a class based on support vector machines, that provides an automatic diagnosis of the material class of a given sample. The classifier uses texture features from an underlying image analysis, the so-called Haralick parameters, and stereologic features such as fractal dimension, Euler parameter, etc. In addition to the class the system provides a sensitivity analysis that allows the user to understand which features are most influential for certain class decisions. The system is fully operational and can be used on the Web.