Human Papillomavirus: Implications for Clinical Medicine (1988)

Editorials1 April 1988Human Papillomavirus: Implications for Clinical MedicineROBERT F. RANDO, Ph.D.ROBERT F. RANDO, Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-108-4-628 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the past 6 years nucleic acid hybridization analysis has helped define more than 45 distinct types of human papillomaviruses. The classification of viral types is based on the viral DNA sequence composition (genotype), rather than on viral structural antigenic features (serotype). A human papillomavirus genome is considered to represent a new viral type if its DNA sequence has less than 50% homology with the genomes of all other defined human papillomavirus types. Twelve of the more than 45 virus types have been found to be associated with anogenital tract lesions.Due to intrinsic problems encountered when studying papillomaviruses, basic...References1. MEISELSFORTIN AR. Condylomatous lesions of the cervix and vagina. I. Cytologic patterns. Acta Cytol. (Baltimore). 1976;20:505-9. MedlineGoogle Scholar2. ROUSBEARD PJ. The progression to carcinoma of virus induced rabbit papillomas (Shope). J Exp Med. 1935;62:523-48. CrossrefMedlineGoogle Scholar3. ORTH G. Epidermodysplasia verruciformis: a model for understanding the oncogenicity of human papillomaviruses. In: EVERD D, CLARK S, eds. Papillomaviruses. Chichester: John Wiley; 1986:157-68. Google Scholar4. GISSMANNSCHWARZ LE. Persistence and expression of human papillomavirus DNA in genital cancer. In: EVERD D, CLARK S, eds. Papillomaviruses. Chichester: John Wiley; 1986:190-7. CrossrefGoogle Scholar5. DE VILLIERSWAGNERSCHNEIDER EDA. Human papillomavirus infections in women with and without abnormal cervical cytology. Lancet. 1987;26:703-6. CrossrefGoogle Scholar6. LORINCZTEMPLEPATTERSONJENSONKURMANLANCASTER AGJARW. Correlation of cellular atypia and human papillomavirus deoxyribonucleic acid sequences in exfoliating cells of the uterine cervix. Obstet Gynecol. 1986;68:508-12. MedlineGoogle Scholar7. KREBS H. The use of topical 5-fluorouracil in the treatment of genital condylomas. In: REID R, ed. Obstet and Gynecol. Clinics of North America; Human Papillomaviruses. Philadelphia: W.B. Saunders Co.; 1987: vol 14:2 p. 559-568. CrossrefGoogle Scholar8. CARPINIELLOMALLOYSEDLACEKZDERIC VTTS. Results of CO2 laser therapy and topical 5-fluorouracil treatment for subclinical condyloma found by magnified penile surface scanning. 1988. In press. Google Scholar9. YANGOKAYAMAHOWLEY YHP. Bovine papillomavirus contains multiple transforming genes. Proc Natl Acad Sci USA. 1985;82:1030-4. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Pennsylvania Hospital Philadelphia, Pennsylvania PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited BySexually Transmitted Infections (Excluding HIV)AndroscopyVerrucous Carcinoma Masquerading as a Giant Fibroepithelial PolypSexually Transmitted Infections (Excluding HIV)Treatment of Human Papillomavirus Gynecologic InfectionsIsolated extragenital bowenoid papulosis of the neckVerrucous carcinoma of the skin and mucosaAndroscopy and Treatment of Human Papillomavirus (HPV) with CO 2 Laser SurgeryA Case of Verrucous Carcinoma Associated with Human Papillomavirus Type 16 DNAReduction in Sexual Risk Behaviors among College Students following a Comprehensive Health Education InterventionDevelopment of a Novel Marker Gene Based Assay System for Detection and Evaluation of Antiviral Agents with Activity against PapillomavirusesBuschke-Loewenstein tumor: Verrucous carcinoma of the penisEffects of a Videotape Intervention on Pap Smear Knowledge, Attitudes and BehaviourSequelae of Sexually Transmitted DiseasesAn Alternate View of the Management of Cervical Human Papillomavirus InfectionsDNA dot-blot hybridization implicates human papillomavirus type 11-DNA in epithelioma cuniculatumGenital Human Papillomavirus InfectionsManagement of the Abnormal Papanicolaou SmearCervical dysplasia and human papillomavirus: Evaluation in an adolescent dysplasia clinicCommon Penile Lesions 1 April 1988Volume 108, Issue 4Page: 628-630KeywordsAntigensDNADNA sequencingHuman papillomavirusLesionsNucleic acids Issue Published: 1 April 1988 PDF DownloadLoading ...