gebhart/patrepeval huggingface dataset:
Triazolo Pyridines Useful as Inhibitors of γ-Secretase and Their Methods of Use (2019)

ADVERTISEMENT RETURN TO ISSUEPREVPatent HighlightNEXTTriazolo Pyridines Useful as Inhibitors of γ-Secretase and Their Methods of UseBenjamin E. Blass*Benjamin E. BlassTemple University School of Pharmacy, Moulder Center for Drug Discovery Research, Philadelphia, Pennsylvania 19140, United States*E-mail: [email protected]More by Benjamin E. Blasshttp://orcid.org/0000-0003-2449-4503Cite this: ACS Med. Chem. Lett. 2019, 10, 9, 1249–1250Publication Date (Web):August 9, 2019Publication History Received28 July 2019Published online9 August 2019Published inissue 12 September 2019https://pubs.acs.org/doi/10.1021/acsmedchemlett.9b00342https://doi.org/10.1021/acsmedchemlett.9b00342editorialACS PublicationsCopyright © 2019 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views1098Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (534 KB) Get e-AlertscloseSUBJECTS:Modulators,Nervous system diseases,Peptides and proteins,Pyridines,Therapeutics Get e-Alerts
Sequential Therapy With Fludarabine, High-Dose Cyclophosphamide, and Rituximab in Previously Untreated Patients With Chronic Lymphocytic Leukemia Produces High-Quality Responses: Molecular Remissions Predict for Durable Complete Responses (2008)

Sequential therapy with F-->C-->R yields improvement in quality of response, with many patients achieving a PCR-negative state.
Large deformation mechanical testing of biological membranes using speckle interferometry in transmission I: Experimental apparatus (1997)

This paper describes an apparatus designed to study large mechanical deformations in biological membranes. The task of mechanically characterizing biological membranes is challenging because of the anisotropic and nonlinear nature of their material properties. The apparatus described here is well suited to the task because it uses speckle interferometry to measure in-plane displacements in a distributed fashion and has multiple degrees of freedom in the applied stress mechanism. In this way few a priori assumptions or restrictions are imposed on the applied stress and strain fields. The interferometer operates in transmission mode to increase the light efficiency of the system since the sample biological membranes are translucent and reflect little light. The experimental results confirm that the strain fields in the biological membranes that are generated in the experiments are highly nonuniform and cannot be properly estimated from a small number of point measurements.
In vivo Evaluation of Human Embryonic Stem Cells Isolated by 57-C11 Monoclonal Antibody (2016)

57-C11-positive hESCs are pluripotent and tumorigenic. The combination of 57-C11 and magnetic beads will be useful to eliminate remaining undifferentiated hESCs for the safe cell transplantation.
How (La)TeX changed the face of Mathematics (2000)

Gunther Ziegler interviewed me by email for this note, which delves into the history of LaTeX.
Differential public physically unclonable functions (2011)

We have developed an ultra low power (well below 1 nano-joule per transaction), ultra high speed (less than 1 nanosecond), and low cost (a few hundred gates) public physically unclonable function (PPUF). We have also developed the first PPUF-based smart card (SC). We analyze and demonstrate the security of this new SC against several families of potential security attacks.
70.1: Touch‐Interactive High Power Efficiency AMOLED Display with Energy Recycling and Self‐Calibration Capabilities (2012)

Abstract A polarizer‐less OLED is introduced with 30% improvement in efficiency. Also, the new OLED structure provides integrated multi‐touch, power recycling/generating, and non‐uniformity /aging self‐calibration capabilities.
Supplemental Figure 2 from M-COPA, a Golgi Disruptor, Inhibits Cell Surface Expression of MET Protein and Exhibits Antitumor Activity against MET-Addicted Gastric Cancers (2023)

&lt;p&gt;Effect of M-COPA on cell surface expression and phosphorylation status of HER3 in MKN-45 cells.&lt;/p&gt;
Fabrication of a Parallel-Series PHEV for the EcoCAR 2 Competition (2013)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;The &lt;i&gt;EcoCAR 2: Plugging into the Future&lt;/i&gt; team at the Ohio State University is designing a Parallel-Series Plug-in Hybrid Electric Vehicle capable of 50 miles of all-electric range. The vehicle features a 18.9-kWh lithium-ion battery pack with range extending operation in both series and parallel modes. This is made possible by a 1.8-L ethanol (E85) engine and 6-speed automated manual transmission. This vehicle is designed to drastically reduce fuel consumption, with a utility factor weighted fuel economy of 51 miles per gallon gasoline equivalent (mpgge), while meeting Tier II Bin 5 emissions standards. This report details the fabrication and control implementation process followed by the Ohio State team during Year 2 of the competition. The fabrication process includes finalizing designs based on identified requirements, building and assembling components, and performing extensive validation testing on the mechanical, electrical and control systems. This effort was made possible through support from the U.S. Department of Energy, General Motors, The Ohio State University, and numerous competition and local sponsors.&lt;/div&gt;&lt;/div&gt;
Performance of a 90-GHz radio-on-radio-over-fiber system suitable for communications in high-speed railways (2014)

We propose a radio access network suitable for communications in high-speed railways employing a radio-on-radio-over-fiber and distributed antenna system. We present a proof-of-concept demonstration of wireless signal transmission over the system at 90 GHz. Standard LTE-A signals using QPSK, 16-QAM and 64-QAM modulation are successfully transmitted and demodulated. Satisfactory transmission performance with measured root-mean-square EVM well under the standard requirement is achieved. The obtained results indicate the potential to make use of the system in high-speed rail communications.
Microwave‐Assisted Synthesis: A Critical Technology Overview (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
The impact of overbalance pressure on the alteration of sandstone geomechanical properties (2022)

Abstract The overbalance pressure drilling technique is well common and practiced during the drilling operations in the petroleum field. This parameter is very critical and affects the drilled formation characteristics, and therefore, the main objective of the current study is to evaluate the impact of overbalance pressure that is applied during the drilling operation on the rock elastic and strength characteristics by employing integrated lab experimental work. Berea Buff sandstone rock type was utilized to interact with water-based drilling fluid (barite-weighted) under an extended range of overbalance pressure [300 to 1000 psi]. The current research presents extensive lab analyses that cover filtration tests for rock-mud interaction, scratch testing for determining the rock strength profile, sonic data acquisition, elastic properties determination, and spectrometry of scanning electron microscope and nuclear magnetic resonance spectrometry to study the internal pore structure changes. The analysis was performed before the mud interaction for the saturated samples (base case) and after applying different overbalance pressure (pre-mud interaction) to evaluate the rock properties alterations. The obtained results showed the high degree of impact of the overbalance pressure on the sonic wave propagation as the compressional and shear wave velocities increased by 17 and 6%, respectively with increasing the overbalance pressure. Poisson’s ratio showed a stable trend, while Young’s modulus showed an increasing trend by 23% increase with the extended range of the overbalance pressure. The rock strength showed deterioration behavior with increasing the overbalance pressure. The unconfined compression strength decreased by 10% and the tensile strength showed a 9% reduction. The internal pore spectrometry showed the rock structure alterations due to mud solids precipitations and filtrate fluid impact on the rock integrity during the rock-mud interaction. In addition, statistical analysis illustrated the high degree of relationship between the recorded rock characteristics with the overbalance pressure as a controlling factor on the rock and mud interaction.
A Time-Delay Suppression Technique for Digital PWM Control Circuit (2010)

This paper describes a digital PWM controller IC without A/D converters. The analog timing converter (ATC) is proposed for output voltage sensing. In this system, analog circuit are realized with an comparator and an D/A converter.
A Statistical Learning Framework for QoS Prediction in V2X (2021)

Managing QoS is one of the most critical and challenging aspects for connected and automated driving to be accepted in reality, as pre-agreed QoS Key-Performance-Indicators (KPIs) such as throughput, latency, and packet delivery ratio may not be guaranteed at all times. Enabling notifications with QoS predictions to vehicle applications presents a way to act upon potential QoS degradation. This, in turn, will make possible to improve overall system reliability while enhancing safety of connected and automated driving. To meet the V2X requirements and deliver QoS prediction with accuracy information, this paper proposes a prediction framework that combines a channel prediction model that maps contextual information into prediction of channel characteristics, with a statistical learning model that delivers QoS prediction with statistical guarantees.
Flexible caching in peer-to-peer information systems (2002)

We view the Internet as supporting a peer-to-peer information system whose components provide services to one another. We model service providers and consumers as autonomous agents. Agents may provide services or give referrals to one another to help find trustworthy services. Once found, some services may be cached. We describe a flexible caching technique that allows peers to operate autonomously (based on their local policies), accommodates heterogeneity of peers, and enables peers to adapt by choosing policies and neighbors as best suits them. In this approach, cache entries are coupled with metadata, thereby allowing the use of heuristics and flexible queries for more informed searches. The entries that are of interest to more agents are replicated at more peers, providing on-demand performance improvement and fault tolerance.
Characterization of an N-acylated glucagon-like peptide-1 derivative by electron capture dissociation (2005)

An N-acylated glucagon-like peptide 1 derivative was characterized by Fourier transform ion cyclotron resonance mass spectrometry. Both electron capture dissociation (ECD) and sustained off-resonance irradiation collisionally activated dissociation (SORI-CAD) were employed. While ECD revealed full sequence coverage, site of modification, branching point, structure of the palmitoylated modification, SORI-CAD produced less complete and more ambiguous information attributable to facile losses of the fatty acid group from both parent and fragments. Thus, ECD showed a superior characterization performance over SORI-CAD in analysis of N-acylated polypeptides.
Nonlocal competition and logistic growth: Patterns, defects, and fronts (2006)

Logistic growth of diffusing reactants on spatial domains with long-range competition is studied. The bifurcations cascade involved in the transition from the homogeneous state to a spatially modulated stable solution is presented, and a distinction is made between a modulated phase, dominated by single or few wave numbers, and the spiky phase, where localized colonies are separated by depleted region. The characteristic defects in the periodic structure are presented for each phase, together with the invasion dynamics in the case of local initiation. It is shown that the basic length scale that controls the bifurcation is the width of the Fisher front, and that the total population grows as this width decreases. A mix of analytic results and extensive numerical simulations yields a comprehensive examination of the possible phases for logistic growth in the presence of nonlocal competition.
Lysis of uninfected HIV-1 gp120-coated peripheral blood-derived T lymphocytes by monocyte-mediated antibody-dependent cellular cytotoxicity (1995)

Previous reports from our laboratory have demonstrated that peripheral blood monocytes (PBM) from HIV-1 infected individuals are de novo activated and are cytotoxic in vitro. Significant monocyte-antibody-dependent cellular cytotoxicity (ADCC) was obtained against HIV-1 inactivated CD4+ CEM target cells coated with HIV-1 in the presence of autologous seropositive serum. Based on these findings, we hypothesized that in HIV-seropositive individuals the monocytes may play an important role in vivo in the autodestruction of non-infected CD4+ T lymphocytes. The present study was designed to test this hypothesis. Monocytes from normal donors activated with M-CSF lysed CD4+ T cells (CEM) coated with gp120 sensitized by plasma from asymptomatic HIV-1+ individuals in a 8 h 51Cr release assay. ADCC cytotoxic activity varied from one individual to another and was a function of the dilution of the individual seropositive plasma used. We then used circulating CD3+ T lymphocytes as targets for ADCC following treatment with actinomycin D to facilitate the release of radioactive 51Cr. Like CEM, ADCC was obtained with CD3+ T cells coated with gp120 in the presence of HIV seropositive plasma and monocytes. Lysis was specific as T cells that were not coated with gp120 were not destroyed. These findings demonstrate that activated peripheral blood derived monocytes can destroy non-infected gp120-coated circulating T lymphocytes by an ADCC-mediated mechanism. Thus, these findings suggest that ADCC may be one mechanism operating in vivo for the destruction of non-infected CD4+ T lymphocytes.
Therapeutic Drug Monitoring for Everolimus in Heart Transplant Recipients Based on Exposure–Effect Modeling (2004)

Everolimus, a proliferation signal inhibitor, is an immunosuppressant that targets the primary causes of progressive allograft dysfunction, thus improving the long-term outcome after heart transplantation. The present study investigated whether therapeutic drug monitoring (TDM) of everolimus would benefit heart transplant patients. Data from a twelve-month phase III trial comparing everolimus (1.5 or 3 mg daily) with azathioprine were used to evaluate everolimus pharmacokinetics, exposure-efficacy/safety and TDM prognostic simulations. Everolimus trough levels were stable in the first year post-transplant and averaged 5.2 +/- 3.8 and 9.4 +/- 6.3 ng/mL in patients treated with 1.5 and 3 mg/day, respectively. Cyclosporine trough levels were similar in all treatment groups. Biopsy-proven acute rejection (BPAR) was reduced with everolimus trough levels > or =3 ng/mL. Intravascular ultrasound (IVUS) analysis showed evidence of reduced vasculopathy at 12 months with increasing everolimus exposure. Unlike cyclosporine, increasing everolimus exposure was not related to a higher rate of renal dysfunction. The TDM simulation, which was based on two everolimus dose adjustments and an initial starting dose of 1.5 mg/day, showed that the simulated BPAR rate (with TDM) was 21% versus 26% in the group with fixed dosing. Therefore, TDM in heart transplantation could optimize immunosuppressive efficacy and reduce treatment-related toxicity.
Stromal, Fibrous, and Fatty Gastrointestinal Tumors in a Patient With a PDGFRA Gene Mutation (2008)

We report the case of a woman with 3 different types of gastrointestinal tumors--stromal, fibrous, and fatty--and a germline defect of the platelet-derived growth factor receptor alpha (PDGFRA) gene (V561D). The patient, now 52 years old, presented in 1977 at age 22 years with a gastric tumor and a duodenal lipoma. Subsequently, she developed obstructing small intestinal fibrous tumors that required 3 laparotomies and intestinal resections. Most recently (in 2002), more than 100 fibrous tumors were resected and also multiple small intestinal lipomas and multiple gastric KIT, PDGFRalpha, and CD34-positive stromal tumors. The nosology of the fibrous tumors was not clear. The lesions were hypocellular and featured poorly outlined spindle, stellate, and polygonal CD34 positive, and KIT- and PDGFRalpha-negative cells. They extended through the muscularis propria, expanded the subserosa, and occasionally extended into the mesentery but did not metastasize. The patient is currently asymptomatic; radiologic study in June 2007 revealed postoperative changes only. None of the patient's primary relatives have had similar tumors.
Preclinical Validation of Multilevel Intraparenchymal Stem Cell Therapy in the Porcine Spinal Cord (2015)

This series supports the functional safety of various injection volumes and numbers in the spinal cord and gives critical insight into important safety thresholds. These results are relevant to all translational programs delivering cell therapeutics to the spinal cord.
Toward practical factory activity recognition (2016)

In a line production system of a factory, a worker repetitively performs predefined operation processes. This paper tries to recognize work by factory workers in an unsupervised manner. Specifically, we propose an unsupervised measurement method for estimating lead time (duration) of each period of an operation process using a wrist-worn accelerometer because the lead time greatly affects productivity of the line production system. Our proposed method automatically finds a frequent sensor data segment as a "motif" that occurs once in each operation period using only prior knowledge about predefined standard lead time of the operation process, and uses the occurrence intervals of the motif to estimate the lead time. We evaluated our method using real factory data and the estimation error was only about 3.5%.
I2-Catalyzed oxidative synthesis of N,4-disubstituted quinazolines and quinazoline oxides (2019)

An easy and efficient approach to the synthesis of N,4-disubstituted quinazoline-2-amine and oxides is described. This transformation proceeds smoothly in the presence of molecular iodine. The metal-free protocol presented here is insensitive to air moisture and operationally simple. This versatile and synthetic methodology is broadly applicable to a variety of N,4-disubstituted quinazoline-2-amines and oxides, which are synthesized in good to excellent yields starting from readily available inexpensive precursors.
DPPA5 Supports Pluripotency and Reprogramming by Regulating NANOG Turnover (2015)

Although a specific group of transcription factors such as OCT4, SOX2, and NANOG are known to play essential roles in pluripotent stem cell (PSC) self-renewal, pluripotency, and reprogramming, other factors and the key signaling pathways regulating these important properties are not completely understood. Here, we demonstrate that the PSC marker Developmental Pluripotency Associated 5 (DPPA5) plays an important role in human PSC (hPSC) self-renewal and cell reprogramming in feeder-free conditions. Compared to hPSCs grown on mouse embryonic fibroblasts, cells cultured on feeder-free substrates, such as Matrigel, Laminin-511, Vitronectin, or the synthetic polymer poly[2-(methacryloyloxy) ethyl dimethyl-(3-sulfopropyl) ammonium hydroxide], had significantly higher DPPA5 gene expression and protein levels. Overexpression of DPPA5 in hPSCs increased NANOG protein levels via a post-transcriptional mechanism. Coimmunoprecipitation, protein stability assays, and quantitative RT-PCR, demonstrated that DPPA5 directly interacted, stabilized, and enhanced the function of NANOG in hPSCs. Additionally, DPPA5 increased the reprogramming efficiency of human somatic cells to induced pluripotent stem cells (hiPSCs). Our study provides new insight into the function of DPPA5 and NANOG regulation in hPSCs.
Exploring power management in multi-core systems (2008)

Power dissipation has become a critical design metric in microprocessor-based system design. In a multi-core system, running multiple applications, power and performance can be dynamically traded off using an integrated power management (PM) unit. This PM unit monitors the performance and power of each core and dynamically adjusts the individual voltages and frequencies in order to maximize system performance under a given power budget (usually set by the operating system). This paper presents a performance and power analysis methodology, featuring a simulation model for multi-core systems that can be easily reconfigured for different scenarios and a PM infrastructure for the exploration and analysis of PM algorithms. Two algorithms have been implemented: one for discrete and one for continuous power modes based on non-linear programming. Extensive experiments are reported, illustrating the effect of power management both at the core and the chip level.
Real-Time Prediction of Transarterial Drug Delivery Based on a Deep Convolutional Neural Network (2022)

This study develops a data-driven reduced-order model based on a deep convolutional neural network (CNN) for real-time and accurate prediction of the drug trajectory and concentration field in transarterial chemoembolization therapy to assist in directing the drug to the tumor site. The convolutional and deconvoluational layers are used as the encoder and the decoder, respectively. The input of the network model is designed to contain the information of drug injection location and the blood vessel geometry and the output consists of the drug trajectory and the concentration field. We studied drug delivery in two-dimensional straight, bifurcated blood vessels and the human hepatic artery system and showed that the proposed model can quickly and accurately predict the spatial–temporal drug concentration field. For the human hepatic artery system, the most complex case, the average prediction accuracy was 99.9% compared with the CFD prediction. Further, the prediction time for each concentration field was less than 0.07 s, which is four orders faster than the corresponding CFD simulation. The high performance, accuracy and speed of the CNN model shows the potential for effectively assisting physicians in directing chemoembolization drugs to tumor-bearing segments, thus improving its efficacy in real-time.