gebhart/patrepeval huggingface dataset:
Estimation of Time and Frequency Offsets in LTE Coordinated Multi-Point Transmission (2013)

We address the impact, estimation and compensation of time and frequency offsets in LTE CoMP. In LTE CoMP, transmissions may come from a different transmission point in every subframe of one millisecond. Due to propagation delay differences and time-frequency synchronization imperfections between the transmission points, the user equipment (UE) receiver is thus exposed to different time- frequency offsets in every subframe. In this paper we illustrate both analytically and numerically the impact of these time and frequency offsets on channel estimation performance and finally on LTE CoMP link-level demodulation performance. Furthermore, we study the applicability of existing LTE reference signals to the time-frequency offset estimation problem. In particular we compare two approaches in which the UE is either aware or unaware of the exact transmission point. Finally, we show with LTE link-level simulations that using the proposed approaches the impacts of time-frequency offsets can be almost perfectly compensated.
Data from A Phase 1 First-in-Human Study of FS118, a Tetravalent Bispecific Antibody Targeting LAG-3 and PD-L1 in Patients with Advanced Cancer and PD-L1 Resistance (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;This phase 1 study (NCT03440437) evaluated the safety, tolerability, pharmacokinetics (PK), and activity of FS118, a bispecific antibody–targeting LAG-3 and PD-L1, in patients with advanced cancer resistant to anti–PD-(L)1 therapy.&lt;/p&gt;Patients and Methods:&lt;p&gt;Patients with solid tumors, refractory to anti–PD-(L)1–based therapy, received intravenous FS118 weekly with an accelerated dose titration design (800 μg to 0.3 mg/kg) followed by 3+3 ascending dose expansion (1 to 20 mg/kg). Primary objectives were safety, tolerability, and PK. Additional endpoints included antitumor activity, immunogenicity, and pharmacodynamics.&lt;/p&gt;Results:&lt;p&gt;Forty-three patients with a median of three prior regimens in the locally advanced/metastatic setting, including at least one anti–PD-(L)1 regimen, received FS118 monotherapy. FS118 was well tolerated, with no serious adverse events relating to FS118 reported. No dose-limiting toxicities (DLT) were observed, and an MTD was not reached. The recommended phase 2 dose of FS118 was established as 10 mg/kg weekly. The terminal half-life was 3.9 days. Immunogenicity was transient. Pharmacodynamic activity was prolonged throughout dosing as demonstrated by sustained elevation of soluble LAG-3 and increased peripheral effector cells. The overall disease control rate (DCR) was 46.5%; this disease control was observed as stable disease, except for one late partial response. Disease control of 54.8% was observed in patients receiving 1 mg/kg or greater who had acquired resistance to PD-(L)1–targeted therapy.&lt;/p&gt;Conclusions:&lt;p&gt;FS118 was well tolerated with no DLTs observed up to and including 20 mg/kg QW. Further studies are warranted to determine clinical benefit in patients who have become refractory to anti–PD-(L)1 therapy.&lt;/p&gt;&lt;p&gt;&lt;i&gt;&lt;a href="https://aacrjournals.org/clincancerres/article/doi/10.1158/1078-0432.CCR-22-3312" target="_blank"&gt;See related commentary by Karapetyan and Luke, p. 835&lt;/a&gt;&lt;/i&gt;&lt;/p&gt;&lt;/div&gt;
Polymer-Aufbereitung und Kunststoff-Compoundierung (2019)

You have accessPolymer-Aufbereitung und Kunststoff-CompoundierungOct 2019Polymer-Aufbereitung und Kunststoff-CompoundierungGrundlagen, Apparate, Maschinen, AnwendungstechnikKlemens Kohlgrüber, Michael Bierdel, Harald RustKlemens Kohlgrüber, Michael Bierdel, Harald Rusthttps://doi.org/10.3139/9783446460799.fmSectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn next chapter FiguresReferencesRelatedDetails 2019Pages: I-XXIPrint ISBN: 978-3-446-45832-1eISBN: 978-3-446-46079-9 Copyright & Permissions© 2019 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
A follow-up of a randomized study comparing two chemotherapy treatments for advanced diffuse histiocytic lymphoma. (1984)

In 1976 we began a randomized study for the treatment of patients with stage III and IV diffuse histiocytic lymphoma. The therapy was either ACOMLA (doxorubicin, cyclophosphamide, vincristine [oncovin], methotrexate with leucovorin rescue, and cytarabine) or CHOP-B (cyclophosphamide, doxorubicin [hydroxydaunorubicin], vincristine [oncovin], prednisone, and bleomycin). A complete response (CR) was achieved in 13 (65%) of 20 patients treated with ACOMLA and in 20 (71%) of the 28 patients treated with CHOP-B. Four patients achieving CR with ACOMLA and three patients treated with CHOP-B have relapsed for an overall relapse rate of 21%. Partial response (PR) was obtained in four patients treated with ACOMLA and five patients treated with CHOP-B. Median follow-up time is 36 months for the combined treatment groups. Multiple regression analysis demonstrated that those patients who were classified by the Lukes-Collins criteria as having histiocytic lymphoma not of follicular center-cell origin (combined T- and B-cell immunoblastic sarcoma) had a significantly worse survival as compared to patients classified with follicular center-cell origin lymphoma (large cell noncleaved, large cell cleaved, and large cell unclassified) with a 40% five-year survival versus an 80% five-year survival (P = .011). The CR rate however for these two large categories of patients was 63% v 73% respectively, and the relapse rates were equivalent. The increased survival in the follicular center-cell origin lymphomas may be related to a longer survival of PRs and relapsed patients as compared to the patients with nonfollicular center-cell lymphomas.
Does the DSA reconstruction kernel affect hemodynamic predictions in intracranial aneurysms? An analysis of geometry and blood flow variations (2017)

The choice of reconstruction kernel for DSA data influences the segmentation result, especially for small arteries. Therefore, if precise morphology measurements or blood flow descriptions are desired, a specific reconstruction setting is required. Furthermore, research groups should be encouraged to denominate the kernel types used in future hemodynamic studies.
Lsm-Based Boundary Training for Concatenative Speech Synthesis (2006)

The level of quality that can be achieved in concatenative text-to-speech synthesis depends, among other things, on a judicious chiseling of the inventory used in unit selection. Unit boundary optimization, in particular, can make a huge difference in the users' perception of the concatenated acoustic waveform. This paper considers the iterative refinement of unit boundaries based on a data-driven feature extraction framework separately optimized for each boundary region. Such unsupervised boundary training guarantees a globally optimal cut point between any two matching units in the inventory. This optimization is objectively characterized, first in terms of convergence behavior, and then by comparing the average inter-unit discontinuity obtained before and after training. Experimental results and listening evidence both underscore the viability of this approach for unit boundary optimization
Reverse, Sub-Pixel Block Matching: Applications within H.264 and Analysis of Limitations (2006)

In this paper the concept of reverse block matching is introduced based on the relativity of motion, especially, the translational motion. As one of the main applications for this technique, sub-pixel motion estimation is revisited to achieve faster, yet efficient video coding when it is to be deployed on a system with limited memory and data caching requirements. Analysis of direct (conventional) and reverse (proposed) sub-pixel motion estimation at the encoder is provided to identify the sources of mismatch between these two techniques. Finally, experimental results are provided for sub-pixel motion estimation, using the reverse block matching scheme within the H.264 encoder. These results show a significant increase in speed and a reduction of required memory at a reasonable cost, in terms of PSNR degradation, when compared to the fastest direct sub-pixel motion estimation methods currently implemented in the reference H.264 codec by HHI.
Immunorecognition of Ring Skeleton of Taxanes by Chicken Egg Yolk Antibodies (1994)

Anti-10 deacetylbaccatin III (DAB) antibodies (IgY) were elicited in hens immunized with a succinyl-DAB/BSA conjugate and extracted from egg yolk. As shown by indirect competitive inhibition enzyme immunoassay (CIEIA), the addition of free-DAB competitively inhibited the binding of affinity purified anti-DAB IgY to DAB/BSA solid phase conjugated antigen. The assay enabled the detection of DAB in concentrations as low as 7.5ng/ml (13.7 nM DAB), whereas anti-DAB IgY did not react with taxol even at a concentration a thousand times higher. The structural requirements of the diterpenoid nucleus for binding to IgY were considered on the basis of the levels of cross-reaction found with 10 authentic taxanes. The results indicate that anti-DAB IgY represents the first high affinity antibody produced capable of recognizing the ring skeleton of taxol precursors.
Source–channel coding with cooperation (2008)

The design of wireless devices and networks present unique design challenges due to the combined effects of physical constraints, such as bandwidth and power, and communication errors introduced through channel fading and noise. The limited bandwidth has to be addressed through a compression operation that removes redundant information from the source. Unfortunately, the removal of redundancy makes the transmitted data not only more important but also more sensitive to channel errors. Therefore, it is necessary to complement the source compression operation with the application of an error control code to do channel coding. The goal of the channel coding operation is to add redundancy back to the source coded data that has been designed to efficiently detect and correct errors introduced in the channel. In this chapter we will study the use of cooperation to transmit multimedia traffic (such as voice or video conferencing). This involves studying the performance of schemes with strict delay constraint where user cooperation is combined with source and channel coding.
Deep Brain Stimulation of Frontal Lobe Networks to Treat Alzheimer’s Disease (2018)

The study objective was to evaluate the safety and efficacy of deep brain stimulation (DBS) at the ventral capsule/ventral striatum (VC/VS) region to specifically modulate frontal lobe behavioral and cognitive networks as a novel treatment approach for Alzheimer's disease (AD) patients. This is a non-randomized phase I prospective open label interventional trial of three subjects with matched comparison groups. AD participants given DBS for at least 18 months at the VC/VS target were compared on the Clinical Dementia Rating-Sum of Boxes (CDR-SB), our primary outcome clinical measure, to matched groups without DBS from the AD Neuroimaging Initiative (ADNI) cohort. Serial 2-Deoxy-2-[18F]fluoro-D-glucose (FDG) positron emission tomography (PET) images of AD participants were also compared longitudinally over time. Three AD DBS participants were matched to subjects from the ADNI cohort. All participants tolerated DBS well without significant adverse events. All three AD DBS participants had less performance decline and two of them meaningfully less decline over time on our primary outcome measure, CDR-SB, relative to matched comparison groups from the ADNI using score trajectory slopes. Minimal changes or increased metabolism on FDG-PET were seen in frontal cortical regions after chronic DBS at the VC/VS target. The first use of DBS in AD at a frontal lobe behavior regulation target (VC/VS) was well-tolerated and revealed less performance decline in CDR-SB. Frontal network modulation to improve executive and behavioral deficits should be furthered studied in AD.
Enhanced etch process for TSV &amp; deep silicon etch (2015)

One of the key challenges of deep Si etch is feature control versus high etch rate. Scallop sizes increase with increased etch rate and uniformity degrades. This paper provides an overview of an enhanced rapid alternating process (RAP) in combination with a hardware design that breaks this trade off. Scallop control is achieved through very fast switching of gasses, bias and pressure (up to 10 times faster than the typical Bosch process). This new RAP is combined with a proprietary gas injection architecture to ensure uniformity of depth, both locally and across the wafer, by ensuring uniform dissociation of feedstock. Finally, this paper will show how a robust design has to address the challenges of increased thermal loads which can manifest as etch rate drifts and depth uniformity variations. The result is an increase in TSV throughput by > 200% and a reduction in scallop size by ten-fold.
Physical paper as the user interface for an architectural design tool (2001)

Early architectural design is a typical example where traditional design tools such as sketching on paper still dominate over computer-assisted tools. Augmented reality is presented as a promising approach towards developing an interaction style that preserves the naturalness of the traditional way of designing, while at the same time providing access to new media. Using the Visual Interaction Platform (VIP-3), a first prototype tool that supports a combination of virtual and physical paper has been realized. We discuss some of the unsolved problems and potential benefits of a user interface based on physical paper.
A derivative-sigmoidal model reproduces operating point-dependent baroreflex neural arc transfer characteristics (2004)

A cascade model comprised of a derivative filter followed by a nonlinear sigmoidal component reproduces the input size dependence of transfer gain in the baroreflex neural arc from baroreceptor pressure input to efferent sympathetic nerve activity (SNA). We examined whether the same model could predict the operating point dependence of the baroreflex neural arc transfer characteristics estimated by a binary white noise input. In eight anesthetized rabbits, we isolated bilateral carotid sinuses from the systemic circulation and controlled intracarotid sinus pressure (CSP). We estimated the linear transfer function from CSP to SNA while varying mean CSP among 70, 100, 130, and 160 mmHg (P(70), P(100), P(130), and P(160), respectively). The transfer gain at 0.01 Hz was significantly smaller at P(70) (0.61 +/- 0.26) and P(160) (0.60 +/- 0.25) than at P(100) (1.32 +/- 0.42) and P(130) (1.36 +/- 0.45) (in arbitrary units/mmHg; means +/- SD; P < 0.05). In contrast, transfer gain values above 0.5 Hz were similar among the protocols. As a result, the slope of increasing gain between 0.1 and 0.5 Hz was significantly steeper at P(70) (17.6 +/- 3.6) and P(160) (14.1 +/- 4.3) than at P(100) (8.1 +/- 4.4) and P(130) (7.4 +/- 6.6) (in dB/decade; means +/- SD; P < 0.05). These results were consistent with those predicted by the derivative-sigmoidal model, where the deviation of mean input pressure from the center of the sigmoidal nonlinearity reduced the transfer gain mainly in the low-frequency range. The derivative-sigmoidal model functionally reproduces the dynamic SNA regulation by the arterial baroreflex over a wide operating range.
The Effect of Intravenous Lidocaine on the Increase in Intraocular Pressure Induced by Tracheal Intubation (1985)

An increase in intraocular pressure (IOP) is observed during and after laryngoscopy and tracheal intubation (1,2). Brief elevation of IOP is of little consequence in normal or even glaucomatous eyes, as long as the eyeball is intact (1). However, in a patient with an ocular laceration, perforation, or recent surgical ocular intervention, even a transient increase in IOP may be hazardous (1,3). Although a small dose of a nonde-polarizing agent such as gallamine or d-tubocurarine given before succinylcholine attenuates the elevation of IOP caused by succinylcholine (4), there is an additional and more significant increase caused by tracheal intubation itself (1,2). During induction of anesthesia, intravenous lidocaine reduces the autonomic responses to laryngoscopy and intubation (5,6), and acts as an effective cough suppressant (7). We evaluated the influence of intravenous lidocaine on the changes in IOP after tracheal intubation.
Cytokines in Chronic Rhinosinusitis. Role in Eosinophilia and Aspirin-exacerbated Respiratory Disease (2015)

CRSwNP was characterized by a predominant type 2 inflammatory environment, whereas CRSsNP did not reflect a classic type 1 milieu, as has been suggested previously. AERD can be distinguished from CRSwNP by elevated ECP levels, but this enhanced eosinophilia is not associated with elevations in traditional type 2 inflammatory mediators associated with eosinophil proliferation and recruitment. However, other factors, including GM-CSF, MCP-1, and tPA, may be important contributors to AERD pathogenesis.
The long and winding road leading to the identification of the hepatitis C virus (2009)

This review describes work conducted largely in my laboratory at the Chiron Corporation between 1982 and 1989 that led to the identification of the hepatitis C virus (HCV). Key colleagues included Dr. Qui-Lim Choo in my laboratory and Dr. George Kuo also of Chiron as well as my collaborator Dr. Daniel Bradley at the CDC who provided many biological samples from the NANBH chimpanzee model. Numerous molecular approaches were explored including the screening of tens of millions of bacterial cDNA clones derived from these materials. While this early genomics approach resulted in the identification of many host gene activities associated with NANBH, no genes of proven infectious etiology could be identified. A separate avenue of our research led to the molecular characterization of the complete hepatitis delta viral genome but unfortunately, this could not be used as a molecular handle for HCV. Largely following input from Dr. Kuo, I initiated a blind cDNA immunoscreening approach involving the large-scale screening of bacterial proteomic cDNA libraries derived from NANBH-infectious chimpanzee materials (prior to the development of PCR technology) using sera from NANBH patients as a presumptive source of viral antibodies. Eventually, this novel approach to identifying agents of infectious etiology led to the isolation of a single small cDNA clone that was proven to be derived from the HCV genome using various molecular and serological criteria. This discovery has facilitated the development of effective diagnostics, blood screening tests and the elucidation of promising drug and vaccine targets to control this global pathogen.
Knowledge Graph Completion via Complex Tensor Factorization (2017)

In statistical relational learning, knowledge graph completion deals with automatically understanding the structure of large knowledge graphs---labeled directed graphs---and predicting missing relationships---labeled edges. State-of-the-art embedding models propose different trade-offs between modeling expressiveness, and time and space complexity. We reconcile both expressiveness and complexity through the use of complex-valued embeddings and explore the link between such complex-valued embeddings and unitary diagonalization. We corroborate our approach theoretically and show that all real square matrices---thus all possible relation/adjacency matrices---are the real part of some unitarily diagonalizable matrix. This results opens the door to a lot of other applications of square matrices factorization. Our approach based on complex embeddings is arguably simple, as it only involves a Hermitian dot product, the complex counterpart of the standard dot product between real vectors, whereas other methods resort to more and more complicated composition functions to increase their expressiveness. The proposed complex embeddings are scalable to large data sets as it remains linear in both space and time, while consistently outperforming alternative approaches on standard link prediction benchmarks.
Analysis and detection of security vulnerabilities in contemporary software (2017)

Contemporary application systems are implemented using an assortment of high-level programming languages, software frameworks, and third party components. While this may help to lower development time and cost, the result is a complex system of interoperating parts whose behavior is difficult to fully and properly comprehend. This difficulty of comprehension often manifests itself in the form of program coding errors that are not directly related to security requirements but can have an impact on the security of the system. The thesis of this dissertation is that many security vulnerabilities in contemporary software may be attributed to unintended behavior due to unexpected execution paths resulting from the accidental misuse of the software components. Unlike many typical programmer errors such as missed boundary checks or user input validation, these software bugs are not easy to detect and avoid. While typical secure coding best practices, such as code reviews, dynamic and static analysis, offer little protection against such vulnerabilities, we argue that runtime verification of software execution against a specified expected behavior can help to identify unexpected behavior in the software. The dissertation explores how building software systems using components may lead to the emergence of unexpected software behavior that results in security vulnerabilities. The thesis is supported by a study of the evolution of a popular software product over a period of twelve years. While anomaly detection techniques could be applied to verify software verification at runtime, there are several practical challenges in using them in large-scale contemporary software. A model of expected application execution paths and a methodology that can be used to build it during the software development cycle is proposed. The dissertation explores its effectiveness in detecting exploits on vulnerabilities enabled by software errors in a popular, enterprise software product.