gebhart/patrepeval huggingface dataset:
Histological evaluation of chronically implanted tissue-engineered-electronic-neural-interface (TEENI) devices (2017)

Neural-interface devices have the potential to isolate and transduce both afferent (sensory) and efferent (motor) neural signals of the peripheral nerve to and from electrical signals in instrumentation for stimulation and recording to produce fine control of advanced prosthetics. In order to potentiate the full spectrum of possible applications, the persistent foreign-body response needs to be addressed. Here we describe the cellular and extracellular components of chronically implanted polyimide threads suspended within a tricomponent hydrogel. The results of these experiments will contribute to design modifications for future fabrications of tissue-engineered-electronic-nerve-interface (TEENI) devices.
Polydactylous limbs in Strong’s Luxoid mice result from ectopic polarizing activity (1995)

Strong's Luxoid (1stD) is a semidominant mouse mutation in which heterozygotes show preaxial hindlimb polydactyly, and homozygotes show fore- and hindlimb polydactyly. The digit patterns of these polydactylous limbs resemble those caused by polarizing grafts, since additional digits with posterior character are present at the anterior side of the limb. Such observations suggest that 1stD limb buds might contain a genetically determined ectopic region of polarizing activity. Accordingly, we show that mutant embryos ectopically express the pattern-determining genes fibroblast growth factor 4 (fgf-4), sonic hedgehog (shh), and Hoxd-12 in the anterior region of the limb. Further, we show that anterior mesoderm from mutant limbs exhibits polarizing activity when grafted into host chicken limbs. In contrast to an experimentally derived polydactylous transgenic mouse, forelimbs of homozygotes show a normal pattern of Hoxb-8 expression, indicating that the duplication of polarizing tissue here occurs downstream or independently of Hoxb-8. We suggest that the 1st gene product is involved in anteroposterior axis formation during normal limb development.
Subspace Properties of Randomized Network Coding (2007)

Randomized network coding has network nodes randomly combine and exchange linear combinations of the source packets. A header appended to the packet, called coding vector, specifies the exact linear combination that each packet carries. The main contribution of this work is to investigate properties of the subspaces spanned by the collected coding vectors in each network node. We use these properties to exhibit the relationship between the network topology and the subspaces collected at the nodes. This allows us to passively infer the network topology for a general class of graphs.
Design optimization of bendable x-ray mirrors (2011)

Convenience and cost often lead to synchrotron beamlines where the final bendable Kirkpatrick-Baez focusing pair must relay the final image to different samples at different image distances e.g., [Proc. FEL2009, 246-249 (2009)] either for different experimental chambers, or diagnostics. We present an initial analytical approach, starting from, and extending the work of Howells et al. [OE 39(10), 2748-62 (2000)] to analyze the trade-offs between choice of mirror, bending couples and the given, shaped sagittal width of the optic. Both experimentally and in simulation, we have found that after an appropriate re-bending, sagittally shaped optics can perform with high quality at significantly different incidence angles and conjugate distances. We present one successful demonstration from the ALS Optical Metrology Beamline 5.3.1, and review some new closed form analytical solutions with a view towards understanding our results.
Three-Dimensional Quantitative Structure-Activity Relationships of Sulfonamide Endothelin Inhibitors (1995)

A three-dimensional quantitative structure-activity relationship (QSAR) using steric and electrostatic fields (comparative molecular field analysis, CoMFA) applied to 36 aryl sulfonamides assayed for endothelin receptor subtype-A (ETA) antagonism provided high cross-validation correlations (0.7) and showed promising predictive ability. The results were validated through trials using scrambled activities as well as trials using scrambled orientation of molecules. CoMFA was used to discriminate between alternate hypothetical biologically active conformations. CoMFA was also used to discriminate between two different molecular superpositions representing possible positioning within the receptor binding site. The preferred superposition supports hypotheses that suggest Tyr129 in the ETA receptor as a key residue for antagonist binding. Significant CoMFA results were obtained when crudely optimized geometries and simple charge schemes were used. The results improved on refinement, most substantially with refinement of the atomic charges.
Challenges and opportunities in multi-sensing microsystems - a case study (2006)

Microsensor arrays deployed in distributed networks are expected to revolutionize fields ranging from medical instrumentation for neural interfaces to environmental monitoring for industrial effluents, weather, and homeland security. This paper reports on an effort to develop a generic multi-sensor environmental monitoring platform which has stimulated substantial research at all levels, ranging from materials, fabrication methods and packaging, to sensor, actuator, circuit, and system design.
Unconventional translation of mammalian LINE-1 retrotransposons (2006)

Long Interspersed Element-1 (LINE-1 or L1) retrotransposons encode proteins required for their mobility (ORF1p and ORF2p), yet little is known about how L1 mRNA is translated. Here, we show that ORF2 translation generally initiates from the first in-frame methionine codon of ORF2, and that both ORF1 and the inter-ORF spacer are dispensable for ORF2 translation. Remarkably, changing the ORF2 AUG codon to any other coding triplet is compatible with retrotransposition. However, introducing a premature termination codon in ORF1 or a thermostable hairpin in the inter-ORF spacer reduces ORF2p translation or L1 retrotransposition to approximately 5% of wild-type levels. Similar data obtained from "natural" and codon optimized "synthetic" mouse L1s lead us to propose that ORF2 is translated by an unconventional termination/reinitiation mechanism.
Novel Processing of Boron Carbide (B4C): Plasma Synthesized Nano Powders and Pressureless Sintering Forming of Complex Shapes (2008)

Abstract : Boron carbide, most often used in personnel armor systems, is rather difficult to form and is almost always densified from ceramic powders under heat and pressure. Recent developments by PPG and Georgia Tech are allowing for the full densification of nano-sized powders through a pressureless sintering route. PPG is manufacturing these powders in a plasma processing technique, and they are less expensive than traditionally produced powders. The powders are fonned directly in the plasma, and they can be doped with densification aids. Pressureless sintering teclmiques developed by Georgia Tech offers a low-cost processing route for B4C that was previously unavailable. Together both efforts will lead to boron carbide with shapes and sizes unavailable today and using a fine-grained domestically produced starting powder.
ChemInform Abstract: Synthesis and Characterization of Molecular Sieves Containing Transition Metals in the Framework (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
IL-15 regulates immature B-cell homing in an Ly49D-, IL-12–, and IL-18–dependent manner (2007)

To complete their maturation and participate in the humoral immune response, immature B cells that leave the bone marrow are targeted to specific areas in the spleen, where they differentiate into mature cells. Previously, we showed that immature B cells actively down-regulate their integrin-mediated migration to lymph nodes or to sites of inflammation, enabling their targeting to the spleen for final maturation. This inhibition is mediated by IFN-gamma, which is transcribed and secreted at low levels by these immature B cells; IFN-gamma expression is extinguished following B-cell maturation. Stimulation of the MHC class I receptor, Ly49D, triggers a signaling cascade that increases transcription of both IL-12 (p40) and IL-18; these, in turn, induce the secretion of IFN-gamma. In the present study, we demonstrate that Ly49D-dependent secretion of IL-12 and IL-18 induces IL-15 expression by immature B cells, and that these 3 factors together regulate IFN-gamma production that inhibits their ability to home to the lymph nodes or to sites of inflammation. Thus, IL-15 controls immature B-cell homing, resulting in shaping the B-cell repertoire to enable an efficient immune response.
IR-assisted ionization of He by attosecond XUV radiation (2009)

In this work we characterize the underlying processes behind the IR-assisted ionization of helium by extreme ultra violet (XUV) attosecond radiation. We show that, if used in the form of an attosecond pulse train, the XUV radiation can have a good spectral resolution as well as good temporal resolution. Our experimental data and associated theoretical calculations show how to use the properties of attosecond XUV radiation to induce a desired excited state of helium, and how to tune the IR laser electric field to control the ionization pathways.
On Ideological Work (Talk at a Conference Attended by Party Cadres from People’s Liberation Army Units under the Nanjing Command and from Jiangsu and Anhui Provinces) (1989)

"On Ideological Work (Talk at a Conference Attended by Party Cadres from People’s Liberation Army Units under the Nanjing Command and from Jiangsu and Anhui Provinces)" published on 08 Dec 1989 by Harvard University Asia Center.
Ultrafast water permeation through nanochannels with a densely fluorous interior surface (2022)

Ultrafast water permeation in aquaporins is promoted by their hydrophobic interior surface. Polytetrafluoroethylene has a dense fluorine surface, leading to its strong water repellence. We report a series of fluorous oligoamide nanorings with interior diameters ranging from 0.9 to 1.9 nanometers. These nanorings undergo supramolecular polymerization in phospholipid bilayer membranes to form fluorous nanochannels, the interior walls of which are densely covered with fluorine atoms. The nanochannel with the smallest diameter exhibits a water permeation flux that is two orders of magnitude greater than those of aquaporins and carbon nanotubes. The proposed nanochannel exhibits negligible chloride ion (Cl<sup>-</sup>) permeability caused by a powerful electrostatic barrier provided by the electrostatically negative fluorous interior surface. Thus, this nanochannel is expected to show nearly perfect salt reflectance for desalination.
Dark current reduction strategies using edge-on aligned donor polymers for high detectivity and responsivity organic photodetectors (2017)

The difluorobenzene-incorporated polymer showed strong ordering in edge-on mode, resulting in a significant reduction in the leakage current, and thus PFBT2OBT:PC<sub>70</sub>BM devices showed highly improved detectivity of over 10<sup>13</sup> Jones at −2V.
Challenges in Preparing Aluminum Alloys for Grain Boundary Characterization (2008)

Extended abstract of a paper presented at Microscopy and Microanalysis 2008 in Albuquerque, New Mexico, USA, August 3 – August 7, 2008
Management of gastric varices (2012)

Watch the interview with the author Watch a video presentation of this article Answer questions and earn CME
A 3D Nanostructured Hydrogel‐Framework‐Derived High‐Performance Composite Polymer Lithium‐Ion Electrolyte (2018)

Solid-state electrolytes have emerged as a promising alternative to existing liquid electrolytes for next generation Li-ion batteries for better safety and stability. Of various types of solid electrolytes, composite polymer electrolytes exhibit acceptable Li-ion conductivity due to the interaction between nanofillers and polymer. Nevertheless, the agglomeration of nanofillers at high concentration has been a major obstacle for improving Li-ion conductivity. In this study, we designed a three-dimensional (3D) nanostructured hydrogel-derived Li<sub>0.35</sub> La<sub>0.55</sub> TiO<sub>3</sub> (LLTO) framework, which was used as a 3D nanofiller for high-performance composite polymer Li-ion electrolyte. The systematic percolation study revealed that the pre-percolating structure of LLTO framework improved Li-ion conductivity to 8.8×10<sup>-5</sup> S cm<sup>-1</sup> at room temperature.
Experimental and Theoretical Studies of Mechanisms in the Homogeneous Catalytic Activation of Carbon Monoxide (1981)

At the outset it is important to clarify the scope of this discussion by the elimination of areas which will not be considered. When one notes that the term "activation of carbon monoxide" may mean a process as little perturbative of the C-O bond as its end-on attachment to a metal atom in carbonyls, or as strongly perturbative as its dissociation to atoms on a metal surface, the need for limits becomes obvious. In this discussion we will consider only the activation of carbon monoxide in the sense that isolable products are formed by the addition of hydrogen to the molecule without complete rupture of all carbon-oxygen bonds, i.e. oxygenates are formed. Within this context carbon monoxide is not the inert molecule so frequently depicted on the basis of its formal triple bond and the remarkable similarity of its physical properties to those of the isoelectronic molecule dinitrogen. (Indeed, if
2 K/spl times/2 K high speed CMOS active pixel sensors for Y2K (2000)

Summary form only given. We are developing a 4 M pixel CMOS active pixel image sensor for 200 fps (800 M pixel/s) high speed visible imaging applications. This sensor development is based on our previous design and characterization experience with both our 1280/spl times/720 pixel, 60 fps progressive scan CMOS APS (60 M pixel/s), and our 1024/spl times/1024 pixel, 500 fps (500 M pixel/s) progressive scan CMOS APS. The former had an on-chip 10 b analog-to-digital converter (ADC), and the latter an on-chip 8 b ADC. The latter is presently the world's highest throughput image sensor, to the best of our knowledge. It dissipates under 400 mW at 500 fps and operates from an approximately 66 MHz master clock with 8 parallel output ports of 8 b each (64 b).
Effektivität von superparamegnetischen Eisenoxid-Nanopartikeln bei der Behandlung von Osteoidosteomen in einem ex-vivo Modell verglichen mit Radiofrequenzablation und Mikrowellenablation (2012)

Zielsetzung: Evaluation von superparamagnetischen Eisenoxidpartikeln (SPIO) in einem elektromagnetischen Feld (EF-Ablation) im Vergleich zur Radiofrequenzablation (RFA) und Mikrowellenablation (MWA).
Mycophenolate mofetil combination therapy improves survival after liver transplantation. A single-center retrospective analysis (2013)

MMF added to immunosuppressive therapy improves patient survival in OLT recipients in general, as well as in patients with HCC and HCV. Prospective studies are needed to determine if a broader application of MMF post-OLT in combination with CNI-tapering could lead to further outcome improvement.
Removal of particle contaminations on sol-gel coated fused silica surface by laser cleaning (2019)

Efficient removal of SiO<sub>2</sub> contaminated particles from sol-gel SiO<sub>2</sub> filmed fused silica surface was achieved by single shot dry laser cleaning and airflow displacement system assisted laser cleaning using a Q switched Nd:YAG pulse laser at 355 nm in wavelength. The experiment result shows that for single-shot laser dry cleaning of sol-gel film fused silica samples under the condition of satisfying the theoretical cleaning threshold, the optimal laser energy density was 2.28 J/cm<sup>2</sup>, which is different from the process parameters of uncoated fused silica. In the optimal process parameters, single shot laser cleaning had obvious cleaning effect on SiO<sub>2</sub> particles with particle diameter larger than 1 μm, and the removal ratio was 64.81%. When the density of particle was too high, the cleaning effect was weakened and the damage to the substrate was caused. The re-attachment of crushed particles also leaded to making the cleaning effect worse. The airflow displacement system assisted laser cleaning method further enhanced the effect of removing the optical surface contaminated particles and the decontamination efficiency was improved to 80.53% at 1.71 J/cm<sup>2</sup>. Our results demonstrated that airflow displacement system will be useful for single shot dry laser cleaning of SiO<sub>2</sub> particles on an optical surface of fused silica.
IMPROVEMENT OF RADIOSENSITIVE LIQUID-CORE MICROCAPSULES BY YTTRIUM POLYMERIZATION (2007)

Microcapsules comprising alginate and hyaluronic acid that can be decomposed by radiation are under development. Previously, we observed that radiation efficiently decomposes microcapsules comprising alginate and hyaluronic acid in the ratio 2:1 by weight. In this study, Yttrium ( Y ) was added to these microcapsules to improve their decomposition by radiation. Hyaluronic acid solutions (0.1% weight/volume) were mixed into 0.2% alginate solution, and carboplatin (0.2 mmol) was added; the resultant was used for capsule preparation. Capsules were prepared by spraying the material into mixtures of 4.34% CaCl 2 solution supplemented with Y at final concentrations from 0 to 1.0 × 10 −2 %. These capsules were irradiated by a single dose of 0.5, 1.0, 1.5, or 2 Gy with 60 Co γ-rays. Immediately after irradiation, we observed the release of the core contents of the microcapsule using a micro Particle Induced X-ray Emission (PIXE) camera. The mean diameter of the microcapsules was 37.3 ± 7.8 μm . Maximum content of radiation-induced release was observed for liquid-core microcapsules prepared by polymerization in a 4.34% CaCl 2 solution supplemented with 5.5 × 10 −3 % Y .
Stability Analysis for an Online Evolving Neuro‐Fuzzy Recurrent Network (2010)

In this chapter, an online evolving neuro-fuzzy recurrent network (ENFRN) is proposed. The network is capable of perceiving the change in the actual system and adapting itself to the new situation. Both structure and parameters learning take place at the same time. The network generates a new hidden neuron if the smallest distance between the new data and all the existing hidden neurons is more than a predefined radius. A new pruning algorithm based on the population density is proposed to use a modified least-squares algorithm to train the parameters of the network. The major contributions of the chapter are: (1) The stability of the algorithm of the proposed evolving neuro-fuzzy recurrent network was proven; and (2) the bound of the average identification error was found. Three examples are provided to illustrate the effectiveness of the suggested algorithm based on simulations. Controlled Vocabulary Terms fuzzy neural nets; least squares approximations; stability
ChemInform Abstract: An Effective Kinetic Resolution of Racemic α‐Arylpropanoic Acids, α‐Arylbutanoic Acids, and β‐Substituted‐α‐arylpropanoic Acids with Bis(9‐phenanthryl)methanol as a New Achiral Nucleophile in the Asymmetric Esterification Using Carboxylic Anhydrides and the Acyl‐Transfer Catalyst. (2011)

Abstract A widely applicable method is developed via generation of mixed anhydrides followed by reaction with bis(9‐phenanthryl)methanol in the presence of (+)‐benzotetramisole as the catalyst.
Multimodality Optical Imaging of Atherosclerotic Plaques Combining Optical Coherence Tomography and Fluorescence Lifetime Imaging (2009)

We demonstrate the advantage of combining high-resolution Fourier domain optical coherence tomography (OCT) with wide-field time-gated fluorescence lifetime imaging microscopy (FLIM) for a comprehensive morphological and biochemical characterization of atherosclerotic vulnerable plaques (VP).
Effect of MD1003 (High Doses of Biotin) in Progressive Multiple Sclerosis: Results of a Pivotal Phase III Randomized Double Blind Placebo Controlled Study (PL2.002) (2015)

OBJECTIVE: To evaluate the efficacy of Biotin 300 mg/day over placebo in patients with progressive multiple sclerosis (PMS). BACKGROUND: Biotin is a water-soluble vitamin acting as a coenzyme for carboxylases involved in key steps of energy metabolism and fatty acids synthesis. Among others, biotin activates acetylCoA carboxylase, a potentially key-enzyme in myelin synthesis. In one previous open-label pilot study involving 23 patients, it was found that high doses of biotin (100 to 600 mg/day) resulted in progressive and sustained improvement of disability in primary and secondary PMS patients. DESIGN/METHODS: This is a randomized, double-blind, multicenter, placebo-controlled (2:1) trial of oral biotin 300 mg / day in patients with secondary or primary PMS with EDSS between 4.5 and 7 and evidence of EDSS progression within the past two years. Treatment duration was 48 weeks. The primary endpoint was the proportion of patients who improved at M9 and confirmed at M12, defined as decreased EDSS (by at least 1 point for EDSS ≤5.5 and .5 point for EDSS 蠅6) or improved TW25 of at least 20[percnt]. Other endpoints included MSWS, CGI, [percnt] patients with stable or worsened EDSS, SF36, FIS, 9HPT. RESULTS: The last patient is scheduled to complete the study January 2015. Baseline characteristics: 154 subjects from 16 sites across France were randomized; mean age 51.4; mean disease duration 16.6 years; 41[percnt] had PPMS and 59[percnt] had SPMS. The mean EDSS score was 6.1. The database will be locked by March 2015. Detailed results from primary and other outcomes will be presented. CONCLUSIONS: This trial will evaluate the efficacy of Biotin 300 mg/d in a randomized, placebo-controlled trial. Effects of treatment with high doses of biotin in patients with PMS will be discussed in the context of future development of high doses of biotin as a novel potential treatment in PMS.
Rethinking Co-design of Neural Architectures and Hardware Accelerators (2021)

Neural architectures and hardware accelerators have been two driving forces for the progress in deep learning. Previous works typically attempt to optimize hardware given a fixed model architecture or model architecture given fixed hardware. And the dominant hardware architecture explored in this prior work is FPGAs. In our work, we target the optimization of hardware and software configurations on an industry-standard edge accelerator. We systematically study the importance and strategies of co-designing neural architectures and hardware accelerators. We make three observations: 1) the software search space has to be customized to fully leverage the targeted hardware architecture, 2) the search for the model architecture and hardware architecture should be done jointly to achieve the best of both worlds, and 3) different use cases lead to very different search outcomes. Our experiments show that the joint search method consistently outperforms previous platform-aware neural architecture search, manually crafted models, and the state-of-the-art EfficientNet on all latency targets by around 1% on ImageNet top-1 accuracy. Our method can reduce energy consumption of an edge accelerator by up to 2x under the same accuracy constraint, when co-adapting the model architecture and hardware accelerator configurations.