gebhart/patrepeval huggingface dataset:
Functional studies on the cholinergic and sympathetic innervation of the rat proximal urethra: effect of pelvic ganglionectomy or experimental diabetes (1989)

1. Isolated rings of rat proximal urethra contracted in response to acetylcholine, noradrenaline, phenylephrine, tachykinins or field stimulation. In the presence of field stimulation-induced contractions, isoprenaline or CGRP produced an inhibitory effect on evoked contractions. 2. Electrical field stimulation produced frequency-related contractions which, when using trains of stimuli, consisted of a phasic and a tonic response. These contractions were abolished by tetrodotoxin (1 microM) but unaffected by hexamethonium (10 microM). 3. Atropine (3 microM) produced a partial inhibition of these nerve-mediated contractions, slightly more evident on the tonic than the phasic response. In the presence of atropine (3 microM), phentolamine (3 microM) or prazosin (1-10 nM) produced an almost complete inhibition of the response to field stimulation. 4. After bilateral removal of the pelvic ganglia, electrical field stimulation was still able to induce tetrodotoxin-sensitive contractions of the rat proximal urethra. However, the inhibitory effect of atropine was much reduced as compared to controls, while the phentolamine-sensitive portion of the response was increased. 5. DMPP (0.1 mM) a nicotinic receptor agonist, produced a contraction (phasic and tonic components) which was strongly inhibited by hexamethonium (10 microM), abolished by prazosin (1 microM) and reduced by tetrodotoxin (3 microM). 6. In urethral rings from diabetic rats (i.v. streptozotocin 7-9 weeks before) the contractile response to acetylcholine or noradrenaline as well as the response to field stimulation were unchanged as compared to controls. 7. Capsaicin (1 microM) produced an inhibitory effect on the nerve-mediated contractions of the rat proximal urethra. This response was abolished by pelvic ganglionectomy but was unaffected in streptozotocin-treated rats. 8. These findings provide functional evidence that both cholinergic and noradrenergic nerves mediate the contractions of the rat proximal urethra. In addition, capsaicin-sensitive sensory nerves can produce certain local motor responses through release of endogenous neuropeptides. In vivo studies are needed to examine the interplay between these differents sets of motor nerves in the regulation of proximal urethra motility.
Supplementary Data S4 from Optimizing precision medicine for breast cancer brain metastases with functional drug response assessment. (2023)

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Investigating Convergent Actions of Genes Linked to Familial Parkinson’s Disease (2008)

These data suggest that LRRK1/2 regulate mitochondrial physiology.
Biomarker Changes as Surrogate Endpoints in Early-Phase Trials in Heart Failure with Reduced Ejection Fraction (2022)

Among 30 relevant biomarkers, a change over time was significantly and independently associated with HF hospitalization/all-cause death only for NT-proBNP. Changes over time were modestly more prognostic than baseline or end-values alone. Changes in biomarkers should be further explored as potential surrogate endpoints in early phase HF trials.
Block copolymers near the microphase separation transition. 2. Linear dynamic mechanical properties (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBlock copolymers near the microphase separation transition. 2. Linear dynamic mechanical propertiesFrank S. BatesCite this: Macromolecules 1984, 17, 12, 2607–2613Publication Date (Print):December 1, 1984Publication History Published online1 May 2002Published inissue 1 December 1984https://pubs.acs.org/doi/10.1021/ma00142a025https://doi.org/10.1021/ma00142a025research-articleACS PublicationsRequest reuse permissionsArticle Views1297Altmetric-Citations178LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: N‐Heterocyclic Carbene Catalyzed Regioselective Oxo‐Acyloxylation of Alkenes with Aromatic Aldehydes: A High Yield Synthesis of α‐Acyloxy Ketones and Esters. (2014)

Abstract A novel organocatalytic process for the facile synthesis of α‐acyloxycarbonyl derivatives via an oxo‐acyloxylation of alkenes with aromatic aldehydes is developed.
Optical Phase Demodulation of a 10GHz RF Signal using Optical Sampling (2008)

For the first time we demonstrate sampling downconversion of a 10GHz phase modulated optical signal using an integrated coherent receiver with feedback. At a downconverted frequency of 100 MHz we measure 19dB improvement in SIR.
Bone marrow transplantation in chronic myelogenous leukemia: Discriminating between good and standard risk patients in chronic phase (1986)

Journal Article Bone marrow transplantation in chronic myelogenous leukemia: Discriminating between good and standard risk patients in chronic phase Get access M. Gyger, M. Gyger Bone Marrow Transplantation Unit, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada Correspondence: Dr. M. Gyger, Maisonneuve-Rosemont Hospital, 5415 boul de L'Assomption, Montreal, Quebec, Canada H1T 2M4 Search for other works by this author on: Oxford Academic Google Scholar C. Perreault, C. Perreault Bone Marrow Transplantation Unit, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada Search for other works by this author on: Oxford Academic Google Scholar R. Bélanger, R. Bélanger Bone Marrow Transplantation Unit, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada Search for other works by this author on: Oxford Academic Google Scholar M. David, M. David Bone Marrow Transplantation Unit, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada Search for other works by this author on: Oxford Academic Google Scholar J. Boileau, J. Boileau Bone Marrow Transplantation Unit, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada Search for other works by this author on: Oxford Academic Google Scholar M. Lacombe, M. Lacombe Bone Marrow Transplantation Unit, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada Search for other works by this author on: Oxford Academic Google Scholar R. Lavallée, R. Lavallée Bone Marrow Transplantation Unit, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada Search for other works by this author on: Oxford Academic Google Scholar G. D'Angelo, G. D'Angelo Bone Marrow Transplantation Unit, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada Search for other works by this author on: Oxford Academic Google Scholar Y. Bonny, Y. Bonny Department of Hematology and Radiotherapy, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada Search for other works by this author on: Oxford Academic Google Scholar E. Tawil E. Tawil Department of Hematology and Radiotherapy, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada Search for other works by this author on: Oxford Academic Google Scholar The International Journal Of Cell Cloning, Volume 4, Issue S1, 1986, Pages 210–214, https://doi.org/10.1002/stem.5530040726 Published: 01 January 1996
Advanced electrocatalytic materials based biosensors for cancer cell detection – A review (2023)

Abstract Herein, we have highlighted the latest developments on biosensors for cancer cell detection. Electrochemical (EC) biosensors offer several advantages such as high sensitivity, selectivity, rapid analysis, portability, low‐cost, etc. Generally, biosensors could be classified into other basic categories such as immunosensors, aptasensors, cytosensors, electrochemiluminescence (ECL), and photo‐electrochemical (PEC) sensors. The significance of the EC biosensors is that they could detect several biomolecules in human body including cholesterol, glucose, lactate, uric acid, DNA, blood ketones, hemoglobin, and others. Recently, various EC biosensors have been developed by using electrocatalytic materials such as silver sulfide (Ag 2 S), black phosphene (BPene), hexagonal carbon nitrogen tube (HCNT), carbon dots (CDs)/cobalt oxy‐hydroxide (CoOOH), cuprous oxide (Cu 2 O), polymer dots (PDs), manganese oxide (MnO 2 ), graphene derivatives, and gold nanoparticles (Au‐NPs). In some cases, these newly developed biosensors could be able to detect cancer cells with a limit of detection (LOD) of 1 cell/mL. In addition, many remaining challenges have to be addressed and validated by testing more real samples and confirm that these EC biosensors are more accurate and reliable to measure cancer cells in the blood and salivary samples.
Inhibition of Collagen Synthesis in Human Episcleral Fibroblasts by Calcium Ionophore A23187 (1995)

Calcium ionophore A23187 inhibits collagen biosynthesis in cultured human episcleral fibroblasts. It is possible that inhibition of collagen biosynthesis could enhance treatment of ocular fibroproliferative disorders, including episcleral fibroproliferation, a leading cause of glaucoma filtering surgery failure.
Block-Normalized Gradient Method: An Empirical Study for Training Deep Neural Network (2017)

In this paper, we propose a generic and simple strategy for utilizing stochastic gradient information in optimization. The technique essentially contains two consecutive steps in each iteration: 1) computing and normalizing each block (layer) of the mini-batch stochastic gradient; 2) selecting appropriate step size to update the decision variable (parameter) towards the negative of the block-normalized gradient. We conduct extensive empirical studies on various non-convex neural network optimization problems, including multi-layer perceptron, convolution neural networks and recurrent neural networks. The results indicate the block-normalized gradient can help accelerate the training of neural networks. In particular, we observe that the normalized gradient methods having constant step size with occasionally decay, such as SGD with momentum, have better performance in the deep convolution neural networks, while those with adaptive step sizes, such as Adam, perform better in recurrent neural networks. Besides, we also observe this line of methods can lead to solutions with better generalization properties, which is confirmed by the performance improvement over strong baselines.
Low-Complexity Geometric Inter-Prediction for Versatile Video Coding (2019)

Non-rectangular block partitioning is a well-known method for improved inter-picture prediction in video coding, enabling better spatial adaptation to the signal properties. This contribution presents the most recent proposal of geometric inter-prediction (GIP) made to the Versatile Video Coding (VVC) standardization activity led by the Joint Video Experts Team (JVET). Implemented in the latest test model VTM-5.0 and evaluated according to the JVET Common Test Conditions, the proposed low-complexity GIP scheme provides objective luma BD-rate reductions of 0.22 % for random access and 0.44 % for low-delay test cases at 7% encoder runtime increase and negligible decoder runtime increase. The coding gain is provided by non-triangular partitioned blocks and in the presence of multiple other VVC coding tools. Furthermore, BD-rate reductions of 2.58 % and 2.78 % can be achieved specifically for pure screen content by employing an adaptive blending filter.
Electronic Absorption, Emission, and Two-Photon Absorption Properties of Some Extended 2,4,6-Triphenyl-1,3,5-Triazines (2022)

We report herein the linear optical properties of some extended 2,4,6-triphenyl-s-triazines of formula 2,4,6-[(1,4-C6H4)C≡C(4-C6H4X)]3-1,3,5-(C3H3N3) (3-X; X = NO2, CN, OMe, NMe2, NPh2) and related analogues 4 and 7-X (X = H, NPh2), before briefly discussing their two-photon absorption (2PA) cross-sections. Their 2PA performance is discussed in relation to 2PA values previously measured for closely related octupoles such as N,N′,N″-triphenylisocyanurates (1-X, 5, and 6-X) or 1,3,5-triphenylbenzenes (2-X). While s-triazines are usually much better two-photon absorbers in the near-IR range than these molecules, especially when functionalised by electron-releasing substituents at their periphery, they present a decreased transparency window in the visible range due to their red-shifted first 1PA peak, in particular when compared with corresponding isocyanurates analogues. In contrast, due to their significantly larger two-photon brilliancy, 2,4,6-triphenyl-s-triazines appear more promising than the latter for two-photon fluorescence bio-imaging purposes. Rationalisation of these unexpected outcomes is proposed based on DFT calculations.
A new composite electrode architecture for energy storage devices (1992)

The research objective is to determine how the electrode microstructure (architecture) affect the performance of the nickel hydroxide electrochemical system. It was found that microstructure and additional surface area makes a difference. The best architectures are the FIBREX/nickel and nickel fiber composite electrodes. The conditioning time for full utilization was greatly reduced. The accelerated increase in capacity vs. cycling appears to be a good indicator of the condition of the electrode/active material microstructure and morphology. Conformal deposition of the active material may be indicated and important. Also higher utilizations were obtained; greater than 80 pct. after less than 5 cycles and greater than 300 pct. after more than 5 cycles using nickel fiber composite electrode assuming a 1 electron transfer per equivalent.
Electrical impedance spectroscopy of plant cells in aqueous buffer media over a wide frequency range of 4 Hz to 20 GHz (2020)

Electrical impedance spectroscopy was performed on suspensions of plant cells in aqueous buffer media over a wide frequency range of 4 Hz to 20 GHz. Custom probes were designed, manufactured, and used for these investigations. Experiments were performed with a custom-made parallel plate probe and impedance analysers in the low-frequency range (4 Hz to 5 MHz), with a custom-made coaxial airline probe and a vector network analyser in the mid-frequency range (100 kHz to 3 GHz), and with a commercial open-ended probe and a vector network analyser in the high-frequency range (200 MHz to 20 GHz). The impedance data acquired were processed in order to eliminate the effects of parasitics and compensate for geometrical differences between the three probes. Following this, the data were fitted to a unified model consisting of the Randles and Debye models. The data were also normalized to a reference measurement, in order to accentuate the effects of cell concentration on the impedance of the suspensions.•The methodology allows for impedance spectroscopy of cell suspensions over a wide frequency range spanning 10 orders of magnitude.•It allows for compensation of parasitics and of geometrical variations between probes, using mathematical techniques.
The aminoglycoside antibiotics. IV. Synthesis of aminodeoxy analogs of neamine. (1980)

An efficient synthesis of the key 3',4'-galacto epoxide intermediate 4 obtained from the known 5,6-O,O'-cyclohexylidene-N,N'-bis-(methoxycarbonyl)-4-O-[2,6-bis(methoxycarbony lamino)-alpha-D-glucopyranosyl]-2-deoxystreptamine (5) is described. Treatment of this epoxide with sodium azide, followed by reduction and acetylation, yielded the protected4'-amino-4'-deoxyneamine 18 (3',4'-diequatorial), whereas treatment with ammonia followed by acetylation yielded the protected 3'-amino-3'-deoxyneamine analog 19 with a diaxial configuration of its 3' and 4' positions. Reaction of the previously described protected 3',4'-allo epoxide 3 with sodium azide yielded separable mixtures of the protected 3'-amino-3'-deoxyneamine 14 and the protected diaxial 4'-amino-4'-deoxyneamine isomer 13, the ratios of products depending on the solvent temperature. Structural assignments for 13, 14, 18 and 19 were based on their PMR spectra. An additional 4'-amino-4'-deoxyneamine analog (24) with an axial configuration as its 4' position was also prepared by azide displacement of an approximately protected 4'-methanesulfonyl neamine intermediate 10. The five protected isomers were deblocked to yield a series of aminodeoxyneamine analogs (15, 16, 20, 21 and 25), all of which were less active in vitro than neamine against a group of Gram-positive and Gram-negative bacteria.
In Situ Gene Expression in Mixed-Culture Biofilms: Evidence of Metabolic Interactions between Community Members (1998)

Microbial communities growing in laboratory-based flow chambers were investigated in order to study compartmentalization of specific gene expression. Among the community members studied, the focus was in particular on Pseudomonas putida and a strain of an Acinetobacter sp., and the genes studied are involved in the biodegradation of toluene and related aromatic compounds. The upper-pathway promoter (Pu) and the meta-pathway promoter (Pm) from the TOL plasmid were fused independently to the gene coding for the green fluorescent protein (GFP), and expression from these promoters was studied in P. putida, which was a dominant community member. Biofilms were cultured in flow chambers, which in combination with scanning confocal laser microscopy allowed direct monitoring of promoter activity with single-cell spatial resolution. Expression from the Pu promoter was homogeneously induced by benzyl alcohol in both community and pure-culture biofilms, while the Pm promoter was induced in the mixed community but not in a pure-culture biofilm. By sequentially adding community members, induction of Pm was shown to be a consequence of direct metabolic interactions between an Acinetobacter species and P. putida. Furthermore, in fixed biofilm samples organism identity was determined and gene expression was visualized at the same time by combining GFP expression with in situ hybridization with fluorescence-labeled 16S rRNA targeting probes. This combination of techniques is a powerful approach for investigating structure-function relationships in microbial communities.
Neuropeptides and bacterial interactions: The example of the impact of the C-type natriuretic peptide (CNP) on Pseudomonas aeruginosa biofilm formation (2018)

International audience
Studying the efficacy of antiplatelet drugs on atherosclerosis by optofluidic imaging on a chip (2022)

Vascular stenosis caused by atherosclerosis instigates activation and aggregation of platelets, eventually resulting in thrombus formation. Although antiplatelet drugs are commonly used to inhibit platelet activation and aggregation, they unfortunately cannot prevent recurrent thrombotic events in patients with atherosclerosis. This is partially due to the limited understanding of the efficacy of antiplatelet drugs in the complex hemodynamic environment of vascular stenosis. Conventional methods for evaluating the efficacy of antiplatelet drugs under stenosis either fail to simulate the hemodynamic environment of vascular stenosis characterized by high shear stress and recirculatory flow or lack spatial resolution in their analytical techniques to statistically identify and characterize platelet aggregates. Here we propose and experimentally demonstrate a method comprising an <i>in vitro</i> 3D stenosis microfluidic chip and an optical time-stretch quantitative phase imaging system for studying the efficacy of antiplatelet drugs under stenosis. Our method simulates the atherogenic flow environment of vascular stenosis while enabling high-resolution and statistical analysis of platelet aggregates. Using our method, we distinguished the efficacy of three antiplatelet drugs, acetylsalicylic acid (ASA), cangrelor, and eptifibatide, for inhibiting platelet aggregation induced by stenosis. Specifically, ASA failed to inhibit stenosis-induced platelet aggregation, while eptifibatide and cangrelor showed high and moderate efficacy, respectively. Furthermore, we demonstrated that the drugs tested also differed in their efficacy for inhibiting platelet aggregation synergistically induced by stenosis and agonists (<i>e.g.</i>, adenosine diphosphate, and collagen). Taken together, our method is an effective tool for investigating the efficacy of antiplatelet drugs under vascular stenosis, which could assist the development of optimal pharmacologic strategies for patients with atherosclerosis.
Transmission Networks and Population Turnover of Echovirus 30 (2008)

Globally, echovirus 30 (E30) is one of the most frequently identified enteroviruses and a major cause of meningitis. Despite its wide distribution, little is known about its transmission networks or the dynamics of its recombination and geographical spread. To address this, we have conducted an extensive molecular epidemiology and evolutionary study of E30 isolates collected over 8 years from a geographically wide sample base (11 European countries, Asia, and Australia). 3Dpol sequences fell into several distinct phylogenetic groups, interspersed with other species B serotypes, enabling E30 isolates to be classified into 38 recombinant forms (RFs). Substitutions in VP1 and 3Dpol regions occurred predominantly at synonymous sites (ratio of nonsynonymous to synonymous substitutions, 0.05) with VP1 showing a rapid substitution rate of 8.3 x 10(-3) substitutions per site per year. Recombination frequency was tightly correlated with VP1 divergence; viruses differing by evolutionary distances of >0.1 (or 6 years divergent evolution) almost invariably (>97%) had different 3Dpol groups. Frequencies of shared 3Dpol groups additionally correlated with geographical distances, with Europe and South Asia showing turnover of entirely distinct virus populations. Population turnover of E30 was characterized by repeated cycles of emergence, dominance, and disappearance of individual RFs over periods of 3 to 5 years, although the existence and nature of evolutionary selection underlying these population replacements remain unclear. The occurrence of frequent "sporadic" recombinants embedded within VP1 groupings of other RFs and the much greater number of 3Dpol groups than separately identifiable VP1 lineages suggest frequent recombination with an external diverse reservoir of non-E30 viruses.