gebhart/patrepeval huggingface dataset:
A Single Administration of the Atypical Psychedelic Ibogaine or its Metabolite Noribogaine Induces an Antidepressant-like Effect in Rats (2020)

Anecdotal reports and open label case studies in humans indicated that the psychedelic alkaloid ibogaine exert profound anti-addictive effects. Ample preclinical evidence demonstrated the efficacy of ibogaine, and its main metabolite noribogaine, in substance use disorder rodent models. In contrast to addiction research, depression-relevant effects of ibogaine or noribogaine in rodents have not been previously examined. We have recently reported that the acute ibogaine administration induced a long-term increase of brain-derived neurotrophic factor mRNA levels in the rat prefrontal cortex, which led us to hypothesize that ibogaine may elicit antidepressant-like effects in rats. Accordingly, we characterized behavioral effects (dose and time-dependence) induced by the acute ibogaine and noribogaine (20 and 40 mg/kg, i.p.) administration in rats using the forced swim test (FST). We also examined the correlation between plasma and brain concentrations of ibogaine and noribogaine and the elicited behavioral response. We found that ibogaine and noribogaine induced a dose- and time-dependent antidepressant-like effect without significant changes of animal locomotor activity. Noribogaine’s FST effect was short lived (30 minutes) and correlated with high brain concentrations (estimated &gt; 8 mM of free drug), while the ibogaine’s antidepressant-like effect was significant at 3 hours. At this time point, both ibogaine and noribogaine were present in rat brain, at concentrations which cannot produce the same behavioral outcome on their own (ibogaine ~ 0.5 mM, noribogaine ~ 2.4 mM). Our data suggest a polypharmacological mechanism underpinning the antidepressant-like effects of ibogaine and noribogaine.
Stick-Slip Suppression in Geared Motor Using Speed-Variant Transient Components of High-Order Motor-Side Normalization Compensator (2019)

This paper proposes a stick-slip suppression method for a geared motor with oil seal. The method is based on speed-dependent variation of the transient components of the estimated frictional disturbance given by a high-order motor-side normalization compensator (MNC) using a differently-allocated poles switch type MNC (DAP-STMNC). It uses a decomposition technique to design the steady and transient characteristics of the high-order MNC separately, and uses a series of speed-dependent parameters to vary the transient characteristics online. The DAP-STMNC proved effective to suppress the stick-slip phenomenon while also suppressing oscillations on stick-slip transitions that arise due to overcompensation. The validity of the proposed method is proved through numerical simulations and experimental results.
Glycation, carbonyl stress and AGEs inhibitors: a patent review (2015)

The reactive carbonyl species and AGEs have recently emerged as novel therapeutic targets for the prevention and treatment of several diseases. Currently, the major concerns with the use of AGEs inhibitors as therapeutic agents are low effectiveness, poor pharmacokinetics and undesirable side effects. Many of the AGEs inhibitors reviewed here possess potent antiglycation activity and are devoid of undesirable side effects. These small molecules inhibitors can, therefore, serve as scaffolds for the development and designing of new AGEs inhibitors as clinical agents.
Absence of Proteoglycan 4 (Prg4) Leads to Increased Subchondral Bone Porosity Which Can Be Mitigated Through Intra‐Articular Injection of PRG4 (2019)

Proteoglycan 4 (PRG4) is a mucin-like glycoprotein important for joint health. Mice lacking Prg4 demonstrate degeneration of the cartilage and altered skeletal morphology. The purpose of this study was to examine if Prg4 deficiency leads to subchondral bone defects and if these defects could be mitigated through intra-articular injection of recombinant human PRG4 (rhPRG4). Mice deficient in Prg4 expression demonstrated increased cartilage thickness and increased subchondral bone porosity compared with C57BL/6 controls. While the porosity of the subchondral bone of Prg4<sup>-/-</sup> mice decreased over time with maturation, intra-articular injection of rhPRG4 was able to forestall the increase in porosity. In contrast, neither hyaluronan (HA) nor methylprednisolone injections had beneficial effects on the subchondral bone porosity in the Prg4 knockout mice. Bone marrow progenitor cells from Prg4<sup>-/-</sup> mice demonstrated reduced osteogenic differentiation capacity at 4 weeks of age, but not at 16 weeks of age. While most studies on PRG4/lubricin focus on the health of the cartilage, this study demonstrates that PRG4 plays a role in the maturation of the subchondral bone. Furthermore, increasing joint lubrication/viscosupplementation through injection of HA or controlling joint inflammation through injection of methylprednisolone may help maintain the cartilage surface, but had no positive effect on the subchondral bone in animals lacking Prg4. Therefore, alterations in the subchondral bone in models with absent or diminished Prg4 expression should not be overlooked when investigating changes within the articular cartilage regarding the pathogenesis of osteoarthritis/arthrosis. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:2077-2088, 2019.
O Anunciado DSM-5: Que implicações em Psiquiatria Forense? (2014)

the main changes proposed are essentially about diagnostic criteria, which, for some of nosological entities, may hinder the outcome of the expert assessment, while for others there could be otherwise, since the introduction of new models closer to reality appears to offer greater objectivity and diagnostic rigor.
Unbalanced operation of current regulated sine-wave interior permanent magnet machines (2010)

The behavior of rotor eccentricities in current regulated interior permanent magnet (IPM) machines is investigated. The study focuses on two typical topologies of significant industrial relevance, i.e. machines with distributed windings with two slots per pole and phase and motors with concentrated coils and with three slots per pole pair, respectively. The effect of stator winding parallel paths is examined for both cases. Coil and terminal electrical quantities, radial forces, and torque ripple were simulated using FEA. Unbalanced operation, where the currents are not equal in parallel phase connections due to the eccentricity, is also investigated. Experimental measurements of electrical quantities and forces with static eccentricity are carried out with two special test fixtures. The experimental measurements validated the simulation results.
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. (2017)

Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) among UK Biobank participants of European ancestry with independent replication in other cohorts, and robust validation of 107 independent loci. We also identify new independent variants at 11 previously reported blood pressure loci. In combination with results from a range of in silico functional analyses and wet bench experiments, our findings highlight new biological pathways for blood pressure regulation enriched for genes expressed in vascular tissues and identify potential therapeutic targets for hypertension. Results from genetic risk score models raise the possibility of a precision medicine approach through early lifestyle intervention to offset the impact of blood pressure-raising genetic variants on future cardiovascular disease risk.
Multi-directional fault detection system (2023)

An apparatus, program product and method checks for nodal faults in a group of nodes comprising a center node and all adjacent nodes. The center node concurrently communicates with the immediately adjacent nodes in three dimensions. The communications are analyzed to determine a presence of a faulty node or connection.
Simultaneous electrical and plasmonic monitoring of potential induced ion adsorption on metal nanowire arrays (2013)

Simultaneous LSPR and electronic sensing of potential induced ion adsorption onto gold nanowire arrays is presented. The formation of a Stern layer upon applying an electrochemical potential generated a complex optical response. Simulation of a lossy atomic layer on the nanowire array using the Multiple Multipole Program (MMP) corresponded very well to the experimentally observed peak position, intensity, and radius of curvature changes. Additionally, a significant voltage-dependent change in the resistance of the gold nanowire array was observed during the controlled formation of the electrical double layer. The results demonstrated that an applied electrochemical potential induces measurable changes in the optical and electrical properties of the gold nanowire surface. This is the first demonstration of combined plasmonic and nanowire resistance-based sensing of a surface process in the literature.
Clean Water through Nanotechnology: Needs, Gaps, and Fulfillment (2020)

Sustainable nanotechnology has made substantial contributions in providing contaminant-free water to humanity. In this Review, we present the compelling need for providing access to clean water through nanotechnology-enabled solutions and the large disparities in ensuring their implementation. We also discuss the current nanotechnology frontiers in diverse areas of the clean water space with an emphasis on applications in the field and provide suggestions for future research. Extending the vision of sustainable and affordable clean water to environment in general, we note that cities can live and breathe well by adopting such technologies. By understanding the global environmental challenges and exploring remedies from emerging nanotechnologies, sustainability in clean water can be realized. We suggest specific pointers and quantify the impact of such technologies.
Synthesis of Carbocyclic Analogues of Thymidine (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Battery Losses In a MMC for BEVS Application (2018)

Objective: This paper analyses the Modular Multilevel Converter (MMC) topology, where each individual Sub Module (SM), in half bridge configuration, is directly fed by an elementary electrochemical cell. Methods: The aim is to investigate how the reference voltages influence the cells currents waveforms, determining how the active powers and the losses are distributed among the cells. Considering a 2-level Voltage Source Inverter (VSI) topology working in the same conditions, the ratio between the MMC total cells losses and VSI total cells losses is calculated. After showing the system architecture and mathematical model, the cells current waveform investigation is presented and detailed both for triangular and sinusoidal voltage reference waveform. Results: Finally, the results are critically discussed with particular focus on the comparison between the MMC and the VSI topologies.
ChemInform Abstract: Synthesis of Bay‐Region Diol Epoxides and Other Derivatives of Benz(h)quinoline. (1988)

Abstract The hydroxybenzoquinoline (I) is oxidized and then reduced to form the anti‐diol (V) via the quinone (II).
Communities of microbial eukaryotes in the mammalian gut within the context of environmental eukaryotic diversity (2014)

Eukaryotic microbes (protists) residing in the vertebrate gut influence host health and disease, but their diversity and distribution in healthy hosts is poorly understood. Protists found in the gut are typically considered parasites, but many are commensal and some are beneficial. Further, the hygiene hypothesis predicts that association with our co-evolved microbial symbionts may be important to overall health. It is therefore imperative that we understand the normal diversity of our eukaryotic gut microbiota to test for such effects and avoid eliminating commensal organisms. We assembled a dataset of healthy individuals from two populations, one with traditional, agrarian lifestyles and a second with modern, westernized lifestyles, and characterized the human eukaryotic microbiota via high-throughput sequencing. To place the human gut microbiota within a broader context our dataset also includes gut samples from diverse mammals and samples from other aquatic and terrestrial environments. We curated the SILVA ribosomal database to reflect current knowledge of eukaryotic taxonomy and employ it as a phylogenetic framework to compare eukaryotic diversity across environment. We show that adults from the non-western population harbor a diverse community of protists, and diversity in the human gut is comparable to that in other mammals. However, the eukaryotic microbiota of the western population appears depauperate. The distribution of symbionts found in mammals reflects both host phylogeny and diet. Eukaryotic microbiota in the gut are less diverse and more patchily distributed than bacteria. More broadly, we show that eukaryotic communities in the gut are less diverse than in aquatic and terrestrial habitats, and few taxa are shared across habitat types, and diversity patterns of eukaryotes are correlated with those observed for bacteria. These results outline the distribution and diversity of microbial eukaryotic communities in the mammalian gut and across environments.
Understanding the effects of chemical reactions at the cathode–electrolyte interface in sulfide based all-solid-state batteries (2019)

Driven by a paradigm shift from conventional liquid-based systems to all-solid-state batteries (ASSBs), the chemo-mechanical behavior of the solid–solid interface is of growing importance for understanding the intricate interfacial phenomena of ASSBs.
Self-assembly of PS-b-P4VP block copolymers of varying architectures in aerosol nanospheres (2012)

Poly(styrene-block-4-vinylpyridine) (PS-b-P4VP) nanospheres are prepared in an aerosol phase where the self-assembly is induced by initial solvent evaporation and subsequent thermal annealing. The block copolymers self-assemble into different structures within solid aerosol nanospheres depending on the relative lengths of the polymer blocks, annealing temperature in the aerosol phase, and solvent composition. The obtained structures are worm-like P4VP domains in a PS matrix with low relative P4VP block lengths whereas alternating lamellae of P4VP and PS in a stacked or onion-like order are found with equal block lengths. With specified solvents and annealing below a glass transition temperature (Tg) this results in phase dimensions smaller than in the corresponding bulk copolymer. At the temperature significantly higher than the Tg the chain segments reach thermal equilibrium, which results in equilibrium structures as in the bulk. The results here show that the instantaneous assembly of polymers blocks in nanospheres can be manipulated in the gas phase to obtain various nanoscale structures which are advantageous, for instance, in designing novel nanosphere-based carrier systems for controlled drug delivery.
Fast scan algorithms on graphics processors (2008)

Scan and segmented scan are important data-parallel primitives for a wide range of applications. We present fast, work-efficient algorithms for these primitives on graphics processing units (GPUs). We use novel data representations that map well to the GPU architecture. Our algorithms exploit shared memory to improve memory performance. We further improve the performance of our algorithms by eliminating shared-memory bank conflicts and reducing the overheads in prior shared-memory GPU algorithms. Furthermore, our algorithms are designed to work well on general data sets, including segmented arrays with arbitrary segment lengths. We also present optimizations to improve the performance of segmented scans based on the segment lengths. We implemented our algorithms on a PC with an NVIDIA GeForce 8800 GPU and compared our results with prior GPU-based algorithms. Our results indicate up to 10x higher performance over prior algorithms on input sequences with millions of elements.
Chemical deposition methods for ferroelectric thin films (2001)

Abstract Chemical deposition methods include a wide spectrum of techniques ranging from chemical solution deposition (CSD) to chemical vapor deposition (CVD) which all have their advantages and drawbacks. The complementary aspects of the methods are demonstrated and film growth and film properties are discussed for examples from different application fields, including high k-dielectrics for highly integrated capacitors, e.g. (Ba, Sr)TiO3, and ferroelectrics, e.g. Pb(Zr, Ti)O3 and (Pb, Ba)TiO3.
Integrated Photonics Research Noise in Semiconductor Cascade Lasers (1999)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text F. Rana, S. G. Patterson, and R. J. Ram, "Integrated Photonics Research Noise in Semiconductor Cascade Lasers," in Integrated Photonics Research, OSA Technical Digest Series (Optica Publishing Group, 1999), paper RMH6. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Capillary Effects on the Phonon Transmission between Liquid and Solid Helium (1981)

The phonon transmission from solid to liquid helium has been measured at temperatures in the range 0.1 to 0.5 K. The results support the theory of Marchenko and Parshin in which the phonon transmission occurs because of capillary effects at the interface.
Interplay of vascular endothelial growth factor receptors in organ-specific vessel maintenance (2022)

Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are quintessential for the development and maintenance of blood and lymphatic vessels. However, genetic interactions between the VEGFRs are poorly understood. VEGFR2 is the dominant receptor that is required for the growth and survival of the endothelium, whereas deletion of VEGFR1 or VEGFR3 was reported to induce vasculature overgrowth. Here we show that vascular regression induced by VEGFR2 deletion in postnatal and adult mice is aggravated by additional deletion of VEGFR1 or VEGFR3 in the intestine, kidney, and pancreas, but not in the liver or kidney glomeruli. In the adult mice, hepatic and intestinal vessels regressed within a few days after gene deletion, whereas vessels in skin and retina remained stable for at least four weeks. Our results show changes in endothelial transcriptomes and organ-specific vessel maintenance mechanisms that are dependent on VEGFR signaling pathways and reveal previously unknown functions of VEGFR1 and VEGFR3 in endothelial cells.
The Solubility of Zinc in Sulfuric Acid (1930)

An apparatus is described whereby the rate of evolution of hydrogen from zinc in acids can be readily measured. A cone‐shaped cast specimen is used, which, after treating in sodium hydroxide to remove superficial metal, is corroded in 20 per cent sulfuric acid, until a constant surface and a constant rate of gas evolution are attained. The specimen is then tested in dilute sulfuric acid, and the rate of dissolution is expressed in terms of cubic centimeters of hydrogen evolved per minute. The effect of minute additions of impurities is measured, using 99.992 per cent zinc as a base. Of the impurities tested, copper, iron, and antimony have the most pronounced effect, in the order named. Cadmium and lead have only a small effect, and aluminum is practically inert. When very small quantities of gelatin are added to the acid, gas evolution is markedly inhibited. Sodium silicate, on the other hand, has only a slightly inhibiting effect.
Unusual Effects Measured Under DC Bias Conditions on MnZn Ferrite Material (2009)

Switch mode power supplies are the predominant form through which power conversion is currently implemented in electronic equipment. Within such power supplies, ferrite cored magnetic components are commonly placed under dc bias conditions which, due to magnetomechanical effects, can result in higher than expected core losses. This paper presents measurements that show the impact of magnetomechanical effects on the losses of a MnZn ferrite core material under low ac excitation and high dc bias conditions. The measurements are made using an accurate measurement circuit, and the results show the impact on losses of magnetomechanical resonance. In addition distorted, figure-eight shaped <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">B</i> - <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">H</i> loops are measured, which are also believed to manifest from magnetomechanical interactions. These <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">B</i> - <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">H</i> loops show that, on a transient basis, magnetomechanical interactions may take place in a manner that is not only lossless, but returns energy back to the excitation supply.
Iron-mediated H2O2 Production as a Mechanism for Cell Type-specific Inhibition of Tumor Necrosis Factor α-Induced but Not Interleukin-1β-induced IκB Kinase Complex/Nuclear Factor-κB Activation (2004)

Coordinated and specific regulation of tumor necrosis factor (TNF) and interleukin (IL)-1 signaling pathways and how and whether they are modified by different agents are key events for proper immune responses. The IkappaB kinase complex (IKK)/NF-kappaB and JNK/AP-1 pathways are central mediators of TNF and IL-1 during inflammatory responses. Here we show that l-mimosine, a toxic non-protein amino acid that has been shown to reduce serum TNFalpha levels and affect inflammatory responses, specifically inhibits TNF-induced IKK but not JNK in a cell type-specific manner. l-Mimosine did not affect IKK and NF-kappaB activation by IL-1beta. l-Mimosine caused cell cycle arrest at G(1)-S phase, but inhibition of IKK was found to be independent of cell cycle arrest. Treatment of cells with l-mimosine resulted in production of H(2)O(2). Addition of FeSO(4) restored IKK activation by TNFalpha as did ectopic expression of catalase or pretreatment of cells with N-aceltyl-l-cysteine, indicating a role for intracellular H(2)O(2) as a mediator of inhibition. Cleavage and degradation of TNF pathway components TNFR1, RIP, and Hsp90 were observed in l-mimosine and H(2)O(2) treated cells indicating a putative mechanism for selective inhibition of TNF but not IL-1beta-induced IKK activation.
RE-MIMO: Recurrent and Permutation Equivariant Neural MIMO Detection (2020)

In this paper, we present a novel neural network architecture for MIMO symbol detection, the <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Recurrent Equivariant MIMO detector</i> (RE-MIMO). It incorporates several important considerations in wireless communication systems, such as robustness to channel misspecification, the ability to handle a varying number of users with a single model, and invariance to the (sequential) order in which the users interact with the system. The decoder consists of three main blocks; one block to inform the decoder of the channel model, one permutation equivariant block based on the successful transformer architecture to model transmitter channel interactions, and one fully connected feedforward network to predict the demodulated symbols for each user. These blocks are chained together into an iterative decoder that is trained through end-to-end backpropagation. RE-MIMO is compared against a broad range of existing methods and the results confirm the ability of the network to achieve the state of the art demodulation accuracy. In particular, RE-MIMO efficiently handles a variable number of transmitters with only a single trained model, is capable of dealing with correlated channels, and is robust to channel misspecification. In terms of computational complexity, RE-MIMO scales favorably with the number of transmitters.