gebhart/patrepeval huggingface dataset:
Engineering of Functional Tendon (2004)

Surgical tendon repair is limited by the availability of viable tissue for transplantation. Because of its relatively avascular nature, tendon is a prime candidate for engineered tissue replacement. To address this problem, cells isolated from rat Achilles tendon were grown to confluence in culture and allowed to self-assemble into a cylinder between two anchor points. The resulting scaffold-free tissue was composed of aligned, small-diameter collagen fibrils, a large number of cells, and an excess of noncollagenous extracellular matrix; all characteristics of embryonic tendon. The stress-strain response of the constructs also resembles the nonlinear behavior of immature tendons, and the ultimate tensile strength is approximately equal to that of embryonic chick tendon, roughly 2 MPa. These physical and mechanical properties indicate that these constructs are the first viable tendons engineered in vitro, without the aid of artificial scaffolding.
The structure of secreted mucins isolated from the adherent mucus gel: comparison with the gene products (1994)

Conference Article| May 01 1994 The structure of secreted mucins isolated from the adherent mucus gel: comparison with the gene products FIONA J.J. FOGG; FIONA J.J. FOGG 1Department of Physiological Sciences, University of Newcastle upon Tyne NE24HH UK Search for other works by this author on: This Site PubMed Google Scholar ADRIAN ALLEN; ADRIAN ALLEN 1Department of Physiological Sciences, University of Newcastle upon Tyne NE24HH UK Search for other works by this author on: This Site PubMed Google Scholar STEPHEN E. HARDING; STEPHEN E. HARDING *Department of Applied Biochemistry and Food Science, University of Nottingham LE12 5RD UK Search for other works by this author on: This Site PubMed Google Scholar JEFFREY P. PEARSON JEFFREY P. PEARSON 1Department of Physiological Sciences, University of Newcastle upon Tyne NE24HH UK Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1994) 22 (2): 229S. https://doi.org/10.1042/bst022229s Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation FIONA J.J. FOGG, ADRIAN ALLEN, STEPHEN E. HARDING, JEFFREY P. PEARSON; The structure of secreted mucins isolated from the adherent mucus gel: comparison with the gene products. Biochem Soc Trans 1 May 1994; 22 (2): 229S. doi: https://doi.org/10.1042/bst022229s Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1994 Biochemical Society1994 Article PDF first page preview Close Modal You do not currently have access to this content.
Transcriptional profiling of rat hypothalamus response to 2,3,7,8-tetrachlorodibenzo-ρ-dioxin (2014)

In some mammals, halogenated aromatic hydrocarbon (HAH) exposure causes wasting syndrome, defined as significant weight loss associated with lethal outcomes. The most potent HAH in causing wasting is 2,3,7,8-tetrachlorodibenzo-ρ-dioxin (TCDD), which exerts its toxic effects through the aryl hydrocarbon receptor (AHR). Since TCDD toxicity is thought to predominantly arise from dysregulation of AHR-transcribed genes, it was hypothesized that wasting syndrome is a result of to TCDD-induced dysregulation of genes involved in regulation of food-intake. As the hypothalamus is the central nervous systems' regulatory center for food-intake and energy balance. Therefore, mRNA abundances in hypothalamic tissue from two rat strains with widely differing sensitivities to TCDD-induced wasting syndrome: TCDD-sensitive Long-Evans rats and TCDD-resistant Han/Wistar rats, 23h after exposure to TCDD (100μg/kg) or corn oil vehicle. TCDD exposure caused minimal transcriptional dysregulation in the hypothalamus, with only 6 genes significantly altered in Long-Evans rats and 15 genes in Han/Wistar rats. Two of the most dysregulated genes were Cyp1a1 and Nqo1, which are induced by TCDD across a wide range of tissues and are considered sensitive markers of TCDD exposure. The minimal response of the hypothalamic transcriptome to a lethal dose of TCDD at an early time-point suggests that the hypothalamus is not the predominant site of initial events leading to hypophagia and associated wasting. TCDD may affect feeding behaviour via events upstream or downstream of the hypothalamus, and further work is required to evaluate this at the level of individual hypothalamic nuclei and subregions.
Developing a Vision of Leadership Educator Professional Practice (2019)

Abstract This chapter explores leadership education as a professional role and developmental journey, and proposes a framework of leadership educator professional development.
Study on Sn-Co alloy Electrodes for Lithium Secondary Batteries (2006)

In our previous work, an amorphous alloy film prepared by electrocodeposition on Cu foil with rough surface was found to transform to a new phase structure during charge-discharge cycle to show more stable reaction with lithium. In this work, we prepared film on copper current collector which originally included the new phase structure, and examined its electrochemical and structural properties by scanning electron microscopy, transmission electron microscopy, X-ray diffraction, extended X-ray absorption fine structure, and magnetic susceptibility measurement. Influence of the phase transformation on the cyclability is discussed in terms of adhesion between the film and current collector.
Transfer hyperfine interaction inCd1−xMnxTe studied by NMR (1993)

NMR measurements of $^{125}\mathrm{Te}$ and $^{113}\mathrm{Cd}$ have been performed on a series of samples of ${\mathrm{Cd}}_{1\mathrm{\ensuremath{-}}\mathit{x}}$${\mathrm{Mn}}_{\mathit{x}}$Te (x=0.01, 0.015, 0.02, 0.029, 0.055). The nuclear spin-lattice relaxation rates of the two nuclei are enhanced by two orders of magnitude compared to the relaxation rates of the same nuclei in the nonmagnetic II-VI semiconductor alloys. Well-resolved $^{113}\mathrm{Cd}$ and $^{125}\mathrm{Te}$ spectra were obtained using the magic-angle-spinning technique. The line shifts are temperature dependent and follow the Curie-Weiss law, indicating that the predominant interaction responsible for the NMR behavior is the transfer hyperfine interaction of the ${\mathrm{Mn}}^{2+}$ ion with the Cd or Te nuclei. All the lines in the Te spectra and all but two of the lines in the Cd spectra are shifted to higher frequencies with reference to the NMR line in CdTe. A full spectral assignment has been obtained based on two assumptions: (i) the Mn ions are randomly distributed in the lattice, and (ii) the transfer hyperfine interaction that causes the line shifts depends on the number of bonds between the Mn ion and the Cd (or Te) ion. According to the spectral assignment, the spin density transferred to the Cd sites in the lattice decreases tenfold from one Cd shell to the next.
Proteolytic regulation of β-catenin by calpain and potential role in cancer (2004)

Proc Amer Assoc Cancer Res, Volume 45, 2004

1442 

Mutations in the regulatory domain of β-catenin have been implicated in cancer. These mutations cause stabilization of β-catenin and increased TCF-dependent transcriptional activity. The cysteine protease calpain has been implicated in human tumorigenesis and is a potential target for therapy. We found that β-catenin is proteolytically cleaved by calpain, resulting in the removal of the N-terminal regulatory domain. Treatment of MCF-7 cells with ionomycin activated calpain and resulted in the generation of a 75-kDa β-catenin fragment. Calpain activation was confirmed by Western analysis of spectrin, a known substrate of calpain. Pre-treatment of cells with calpain inhibitors blocked β-catenin cleavage, implicating calpain in this process. The β-catenin75 fragment was also generated by calpain in vitro . β-catenin cleavage resulted in an increase in TCF-dependent transcriptional activity, and this activity was blocked by pre-treatment of cells with calpain inhibitors. β-catenin75 accumulated in the nucleus, supporting a role for β-catenin75 in enhanced TCF-dependent transcriptional activity. Expression analysis of m-calpain cDNA levels in a prostate cancer microarray demonstrated increased m-calpain levels in 49 localized and 19 metastatic prostate cancer samples compared to 26 normal prostate samples. These data demonstrate that calpain can proteolytically cleave β-catenin resulting in a stable and transcriptionally active 75-kDa fragment. Given the low frequency of β-catenin mutation in some cancers, β-catenin cleavage by calpain might represent a novel mechanism by which β-catenin is activated during tumorigenesis.
Development and validation of an Onchocerca ochengi adult male worm gerbil model for macrofilaricidal drug screening (2019)

We have developed and validated a novel gerbil O. ochengi adult male worm model for testing new macrofilaricidal drugs in vivo. It was also used to determine the efficacy of oxfendazole in vivo.
Efficient encoding of speech LSP parameters using the discrete cosine transformation (2003)

The intraframe and interframe correlation properties are used to develop two efficient encoding algorithms for speech line spectrum pair (LSP) parameters. The first algorithm (2-D DCT), which requires relatively large coding delays, is based on two-dimensional (time and frequency) discrete cosine transform coding techniques; the second algorithm (DCT-DPCM), which does not need any coding delay, uses one-dimensional discrete cosine transform in the frequency domain and DPCM (differential pulse-code modulation) in the time domain. The performances of these systems for different bit rates and delays are studied, and appropriate comparisons are made. It is shown that an average spectral distortion of approximately 1 dB/sup 2/ can be achieved with 21 and 25 bits/frame using the 2-D DCT and DCT-DPCM schemes, respectively. This is a noticeable improvement over the previously reported bit rates of 32 bits/frame and above.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Mirabegron: a safety review (2010)

Mirabegron is a β(3)-adrenoceptor agonist developed to fulfill the need for a more convenient therapy and provide an improved safety/efficacy profile for OAB patients with advanced age and cognitive deficit. It has been well tolerated with significant efficacy in reducing the number of incontinence episodes and mean micturition frequency. The most commonly reported toxic effects of mirabegron are gastrointestinal adverse events and headache.
Improved Pediatric MR Imaging with Compressed Sensing (2010)

A combination of parallel imaging and compressed sensing is feasible in a clinical setting and may provide higher resolution and/or faster imaging, addressing the challenge of delineating anatomic structures in pediatric MR imaging.
Interception of dimethylcarbene with pyridine: a laser flash photolysis study (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInterception of dimethylcarbene with pyridine: a laser flash photolysis studyDavid A. Modarelli and Matthew S. PlatzCite this: J. Am. Chem. Soc. 1991, 113, 23, 8985–8986Publication Date (Print):November 1, 1991Publication History Published online1 May 2002Published inissue 1 November 1991https://pubs.acs.org/doi/10.1021/ja00023a079https://doi.org/10.1021/ja00023a079research-articleACS PublicationsRequest reuse permissionsArticle Views141Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Caractéristiques des prolactinomes résistants aux agonistes dopaminergiques (2010)

peer reviewed
C—H...X(X= O, N or π) interactions in benzyl carbamate (2012)

The crystal packing and interaction energy of benzyl carbamate, C(8)H(9)NO(2), have been analysed in detail by the PIXEL method. Benzyl carbamate forms layers of hydrogen-bonded molecules, with the layers connected by weaker C-H...π interactions. According to the PIXEL analysis, combinations of C-H...X (X = O, N or π) interactions are comparable in energy with hydrogen bonding. These interactions are necessary for explaining the geometry and the assembly of the layers.
Supplementary Table from Targeting a Radiosensitizing Antibody–Drug Conjugate to a Radiation-Inducible Antigen (2023)

Supplementary Table from Targeting a Radiosensitizing Antibody–Drug Conjugate to a Radiation-Inducible Antigen
Abstract B44: Keratin-associated protein 5-5 controls cytoskeletal function and cancer cell vascular invasion (2016)

Abstract Cancer cell vascular invasion is a crucial step in the malignant progression towards metastasis. Here we used a genome-wide RNAi screen with E0771 mammary cancer cells to uncover drivers of endothelial monolayer invasion. We identified keratin-associated protein 5-5 (Krtap5-5) as a candidate. Krtap5-5 belongs to large family of cysteine-rich proteins that is implicated in crosslinking keratin intermediate filaments during hair formation. To date, no role of these proteins in cancer has been reported. We found that depletion of Krtap5-5 from cancer cells led to cell blebbing, a loss of keratins 14 and 18 in addition to the upregulation of vimentin intermediate filaments. Krtap5-5 depletion did not impact cell viability but reduced cell motility and extravasation of cancer cells into tissues in a zebrafish model of extravasation. We conclude that Krtap5-5 is a previously unknown regulator of cytoskeletal function in cancer cells that modulates cell motility and vascular invasion. Citation Format: Eric B. Berens, Ghada M. Sharif, Marcel O. Schmidt, Casey W. Shuptrine, Louis M. Weiner, Eric Glasgow, Anna T. Riegel, Anton Wellstein. Keratin-associated protein 5-5 controls cytoskeletal function and cancer cell vascular invasion. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Metastasis; 2015 Nov 30-Dec 3; Austin, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(7 Suppl):Abstract nr B44.
HealthSense (2008)

Remote patient monitoring generates much more data than healthcare professionals are able to manually interpret. Automated detection of events of interest is therefore critical so that these points in the data can be marked for later review. However, for some important chronic health conditions, such as pain and depression, automated detection is only partially achievable. To assist with this problem we developed HealthSense, a framework for real-time tagging of health-related sensor data. HealthSense transmits sensor data from the patient to a server for analysis via machine learning techniques. The system uses patient input to assist with classification of interesting events (e.g., pain or itching). Due to variations between patients, sensors, and condition types, we presume that our initial classification is imperfect and accommodate this by incorporating user feedback into the machine learning process. This is done by occasionally asking the patient whether they are experiencing the condition being monitored. Their response is used to confirm or reject the classification made by the server and continually improve the accuracy of the classifier's decisions on what data is of interest to the health-care provider.
Untersuchungen zur kationischen Polymerisation von reaktiven Monomeren mit Pikrat‐Gegenionen (1988)

Abstract Die Rolle von Pikrat‐Gegenionen im Wachstumsmechanismus der kationischen Vinylpolymerisation wird diskutiert. Die Polymerisation von p‐Methoxystyren wird mit den Initiatorsystemen Triphenylmethyliumpikrat und Pikrinsäure experimentell durchgeführt. Dabei kann bei der Initiierung mit Triphenylmethyliumpikrat das Monoaddukt zwischen Triphenylmethylium und p‐Methoxystyren isoliert werden. Als Gegenion wird eine Pikrat × 2.Pikrinsäure‐Spezies vorgeschlagen. Auf der Grundlage von HPLC‐und kinetischen Untersuchungen schlagen wir für die mit Pikrinsäure initiierte p‐Methoxystyrenpolymerisation eine übertragungsfreie Wachstumsreaktion vor. Der Verlauf der mit Pikrinsäure initiierten Polymerisation von Isobutylvinylether in zwei Etappen mit unterschiedlichem Mechanismus konnte mit Hilfe von HPLC, kinetischen Messungen und Konduktometrie nachgewiesen werden. Der Mechanismus dieses komplexen Reaktionsablaufes wird diskutiert. Die Bildung von Aldehydendgruppen im Polymer wird mit Hilfe von IR‐spektroskopischen Messungen und 2,4‐Dinitrophenylhydrazonbildung nachgewiesen. Die mit Pikrinsäure initiierte Polymerisation von N‐Vinylcarbazol verläuft vorzugsweise über freie, solvatisierte Ionen. Auf der Grundlage des experimentellen Datenmaterials wird ein Mechanismus der übertragungsarmen Wachstumsreaktion in bezug auf ein allgemeines energetisches Schema diskutiert.
International remote collaboration enabled inaugural endoscopic sleeve gastroplasty in Japan (2021)

Obesity causes multiple conditions such as type 2 diabetes, cardiovascular disease, and so on, and an intervention is needed for controlling weight and improving metabolic syndrome. However, the effectiveness of lifestyle interventions and pharmacotherapy are restrictive for losing weight. Endoscopic sleeve gastroplasty (ESG) was developed as a new therapy, picking the best of both medication and surgery, less invasive and more effective. Recently, ESG is gradually spreading in Western countries, but there is Case report doesn't need conclusion/result for Japanese patients. We herein reported the first clinical case of ESG in Japan. Given the situation of the pandemic of COVID-19, we could not invite a proctor from Western countries and receive the instruction of the device setting and maneuver face to face. Thus, we conducted the training for device setting, maneuver, and operation under a web-based international remote collaboration. Eventually, we completed ESG without an adverse event. We could prove this web-based proctor system was useful through the introduction of ESG in Japan. The international remote collaboration could become a new normal even in the endoscopy field post-COVID-19 era.
Power and bandwidth optimization for personal communications mobility tracking (2002)

Mobile users maintaining communication with a wireline network via wireless links form the basis for personal communications. The wireline network tracks the current location of each user at a coarse level when the user is inactive, and refines this knowledge by paging when the user is called. Conventionally, this task of mobility tracking is achieved as follows. The geographical area of interest is divided into registration areas which consist of a large number of cells, where the cell is the coverage area of an individual radio port. Databases in the network keep track of which registration area the user is in. The user monitors beacons broadcast by the radio ports to detect a change in registration area, and notifies the network of such a change when it happens. When the user is called, all cells in that registration area are paged using wireless broadcast. Paging all cells in a registration area for each call (a call may refer to either voice or data communication) may be wasteful of downlink bandwidth if the user does not move much between calls. This may be particularly important if calls are actually bursts of data to a relatively immobile, though portable, computer. On the other hand, keeping closer track of a user's location involves additional expenditure of portable power and uplink bandwidth for the user to announce his or her location more frequently to the network. In the paper, the author provides a mathematical formulation for this tradeoff.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Alterations in T Lymphocyte Profiles of Bronchoalveolar Lavage Fluid from SIV- and Pneumocystis carinii -Coinfected Rhesus Macaques (2002)

The goal of this study was to examine SIV- and Pneumocystis carinii-coinfected rhesus macaques as a model of P. carinii infection in HIV-seropositive humans. The influence of P. carinii infection on the cellular composition of bronchoalveolar lavage (BAL) fluid from SIV-infected and normal rhesus macaques was examined by flow cytometric analysis and polymerase chain reaction (PCR). BAL fluid from SIV- and P. carinii coinfected macaques showed a substantial T lymphocyte influx composed of more than 90% CD8+ T cells. These results are in contrast to BAL fluid from SIV-infected macaques with no detectable P. carinii-specific PCR product, where CD4+ T cells were present in significant numbers and the CD8+ T cell population was less than 70% of total CD3+ lymphocytes. We observed no significant differences in peripheral blood CD4+ or CD8+ T cell levels in the SIV-infected animals, regardless of P. carinii status, indicating that the CD8+ T cell infiltration in the lungs of the P. carinii-positive animals was likely the result of P. carinii infection. These results demonstrate that although peripheral blood CD4+ T cell levels are predictive of susceptibility to P. carinii infection in this model, the levels are not reflective of the T cell profile in the lung during SIV and P. carinii coinfection. The SIV- and P. carinii-coinfected macaques showed a spectrum of lung disease severity that was histologically similar to human P. carinii pneumonia (PCP). Interestingly, even mild P. carinii infection was sufficient to alter the normal CD4+/CD8+ T cell profiles in the lungs of SIV-infected rhesus macaques. These results are similar to immunologic findings in human AIDS-associated PCP and support the usefulness of this model in the study of immune responses to P. carinii.
The Relationship between Bone Tissue Strain and HAp Crystals Strain Under Tensile Loading (2004)

Bone tissue is a composite material composed of hydroxyapatite (HAp) and collagen. As HAp particles in bone tissue are crystal structure, X-ray diffraction method can be used to measure the lattice strain of HAp. This work shows the relationship between lattice strain of HAp crystals and macroscopic strain of bone tissue. The strip specimens of30×6×0.8mm in size were cut from cortical bone in a shaft of bovine femur. The long axis of the specimen was aligned with the bone axial and tangential direction. A tensile device was developed to apply tensile load to the specimen during the X-ray irradiation. Macroscopic strain was measured by a strain-gage glued on the surface of the specimen. Lattice strain of HAp in the specimen was measured by the X-ray diffraction method. As a result, the relationship between applied macroscopic strain and lattice strain was found to depend on Young's modulus of bone tissue.