gebhart/patrepeval huggingface dataset:
Infrared radiation from cage bedding moderates rat inflammatory and autoimmune responses in collagen-induced arthritis (2021)

The development of collagen type II (CII)-induced arthritis (CIA), a model of rheumatoid arthritis, in rats housed in cages with bedding composed of Celliant fibres containing ceramic particles, which absorb body heat and re-emit the energy back to the body in the form of infrared radiation (+IRF rats), and those housed in cages with standard wooden shaving bedding (-IRF control rats) was examined. The appearance of the first signs of CIA was postponed, while the disease was milder (judging by the arthritic score, paw volume, and burrowing behaviour) in +IRF compared with -IRF rats. This correlated with a lower magnitude of serum anti-CII IgG antibody levels in +IRF rats, and lower production level of IL-17, the Th17 signature cytokine, in cultures of their paws. This could be partly ascribed to impaired migration of antigen-loaded CD11b + dendritic cells and their positioning within lymph nodes in +IRF rats reflecting diminished lymph node expression of CCL19 /CCL21. Additionally, as confirmed in rats with carrageenan-induced paw inflammation (CIPI), the infrared radiation from Celliant fibres, independently from immunomodulatory effects, exerted anti-inflammatory effects (judging by a shift in pro-inflammatory mediator to anti-inflammatory/immunoregulatory mediator ratio towards the latter in paw cultures) and ameliorated burrowing behaviour in CIA rats.
Méthode de ``Fast Marching'' générique pour le ``Shape From Shading'' (2006)

National audience
Clinical Associations of the Risk Alleles of HLA-Cw6 and CCHCR1*WWCC in Psoriasis (2007)

The PSORS1 locus is the consistently replicated genetic risk factor for psoriasis. Clinical associations with the main marker allele of PSORS1, HLA-Cw6, have been addressed in a number of studies, but clinical associations have not been used as a way to distinguish the effects of the neighbouring candidate genes in PSORS1. Our results show that HLA-Cw6 and CCHCR1 risk allele associations with clinical features of psoriasis are predictably highly similar in a Finnish nationwide cohort of 379 psoriasis patients. The clinical profiling of a small group of patients (n=34) who were HLA-Cw6- but CCHCR1*WWCC positive suggested that no great differences existed between them and HCR-Cw6- patients. HCR+ genotype (as well as Cw6+ genotype) correlated for the first time positively with female sex and, in contrast with previous studies, negatively with disease severity. Presence of psoriatic arthritis was more pronounced in HCR- psoriasis (as well as in Cw6- psoriasis). Clinical profiling may be a useful approach to distinguishing genetic effects of candidate genes even within a locus in sufficiently large cohorts.
Acoustic front-end processing for communication systems (2002)

Summary form only given. As communication systems have become more mobile and portable, we now have situations where audio communication in difficult acoustic environments is common. Speech coders at low bit rates tend to have problems with non-speech signals that are typically found in noisy acoustic environments. As a result, there can be degradation in the perceived audio quality for low-bit rate coders in noisy environments. One solution that has not been well studied, is the interaction of the acoustic front-end with speech coders in these difficult environments. Clearly an understanding of the end-to-end communication channel including the acoustic front-end will be necessary in order to optimize signal coding. Another area where acoustic front-end processing will play a large role in speech and audio coding is Internet protocol (IP) based communication networks. IP networks enable us to "easily" deliver wider bandwidth and multiple channels of audio for more realistic and transparent telecommunication. Sound transduction for hands-free teleconferencing has audio quality issues similar to the mobile communication problem. This article concentrates on some of the work that we have been doing at Bell Labs on the hands-free telecommunication problem with an emphasis on microphone arrays and acoustic echo cancellation. Finally, some new areas for possible collaboration between the speech coding and electroacoustics communities to improve mobile and hands-free communication are suggested.
HIV-1 Nef-induced FasL induction and bystander killing requires p38 MAPK activation. Commentary (2005)

The human immunodeficiency virus (HIV) has been reported to target noninfected CD4 and CD8 cells for destruction. This effect is manifested in part through up-regulation of the death receptor Fas ligand (FasL) by HIV-1 negative factor (Net), leading to bystander damage. However, the signal transduction and transcriptional regulation of this process remains elusive. Here, we provide evidence that p38 mitogen-activated protein kinase (MAPK) is required for this process. Loss-of-function experiments through dominant-negative p38 isoform, p38 siRNA, and chemical inhibitors of p38 activation suggest that p38 is necessary for Nef-induced activator protein-1 (AP-1) activation, as inhibition leads to an attenuation of AP-1-dependent transcription. Furthermore, mutagenesis of the FasL promoter reveals that its AP-1 enhancer element is required for Net-mediated transcriptional activation. Therefore, a linear pathway for Nef-induced FasL expression that encompasses p38 and AP-1 has been elucidated. Furthermore, chemical inhibition of the p38 pathway attenuates HIV-1-mediated bystander killing of CD8 cells in vitro.
Preparation and Analysis of 1-Chloronaphthalene for Highly Refractive Electrowetting Optics (2009)

High-index oils are critical to the performance of optical electrowetting devices, such as lenses, prisms, and retroreflectors. Herein, the preparation and electrowetting analysis of 1-chloronaphthalene are reported. When 1-chloronaphthalene is mixed with small amounts of an alkane, the following properties can be achieved: refractive index > 1.60, viscosity < 5 cP for rapid switching, operation at <10 V, and +/-45 degrees of electrowetting modulation around the condition for a flat meniscus (90 degrees ).
Structure and Regulation of the Mouse ing1 Gene (1999)

The human ING1 gene encodes nuclear protein p33(ING1), previously shown to cooperate with p53 in cell growth control (Garkavtsev, I., Grigorian, I. A., Ossovskaya, V. S., Chernov, M. V., Chumakov, P. M., and Gudkov, A. V. (1998) Nature 391, 295-298). p33(ING1) belongs to a small family of proteins from human, mouse, and yeast of approximately the same size that show significant similarity to one another within the C-terminal PHD finger domain and also contain an additional N-terminal region with subtle but reliably detectable sequence conservation. Mouse ing1 is transcribed from three differently regulated promoters localized within a 4-kilobase pair region of genomic DNA. The resulting transcripts share a long common region encoded by a common exon and differ in their 5'-exon sequences. Two transcripts are translated into the same protein of 185 amino acids, the mouse equivalent of the human p33(ING1), while the third transcript encodes a longer protein that has 94 additional N-terminal amino acids. Overexpression of the longer protein interferes with the accumulation of p53 protein and activation of p53-responsive promoters after DNA damage. Between the two products of ing1, only the longer one forms a complex with p53 detectable by immunoprecipitation. These results indicate that a single gene, ing1, encodes both p53-suppressing and p53-activating proteins that are regulated by alternative promoters.
Interaction of C1q with beta 2-microglobulin. (1984)

Beta 2-microglobulin aggregated with glutaric dialdehyde was efficiently bound to C1q in fluid and solid phase assay systems. Furthermore, affinity chromatography experiments suggested reactivity of monomeric beta 2-microglobulin with C1q. In spite of its C1q binding capacity, the aggregated beta 2-microglobulin did not activate the C1 complex in serum. This however, might have been due to the mode of aggregation.
845: Extended Biopsy Schemes are Associated with Similar Pathological Characteristics but Lower Biochemical Recurrence than Sextant Biopsy (2007)

INTRODUCTION AND OBJECTIVE: Historically extended biopsy schemes were associated with increased detection of clinically insignificant prostate cancer (PCa). We assessed the difference in pathological stage and the rate of biochemical recurrence (BCR) after radical prostatectomy (RP) according to sextant versus extended (10 or more cores) biopsy scheme, in contemporary patients.
Thesis title: STRUCTURAL AND NETWORK-BASED METHODS FOR KNOWLEDGE-BASED SYSTEMS (2011)

In recent years, there has been considerable interest in Learning by Reading and Machine Reading systems. These systems can learn thousands or even millions of facts from the Web. But to exploit this opportunity, we must address two issues: (a) Efficient first-order reasoning systems can be built today only for small-to-medium sized knowledge bases and by careful hand-tuning of inference mechanisms and representations. As knowledge bases grow, better ways to automatically use such knowledge efficiently must be found. (b) Secondly, how do reasoning systems that learn evolve over time? Characterizing the evolution of these systems is important for understanding their limitations and gaining insights into the interplay between learning and reasoning. In this work, we address these problems by focusing on the systemic properties of knowledge-based systems. We show that ideas from the fields of complex networks, SAT solving, and game theory can be used to improve Q/A performance in large knowledge-based learning systems.
Interactions of Antimicrobial Peptide Chrysophsin-3 with Bacillus anthracis in Sporulated, Germinated, and Vegetative States (2013)

Bacillus anthracis spores contain on their surface multilayered protein coats that provide barrier properties, mechanical strength, and elasticity that aid in protecting the sporulated state and preventing germination, outgrowth, and transition into the virulent vegetative bacterial state. In this work, the antimicrobial peptide (AMP) chrysophsin-3 was tested against B. anthracis in each of the three distinct metabolic states (sporulated, germinated, and vegetative) for its bacteria-killing activity and its ability to modify the surface nanomechanical properties. Our results provide the first demonstration that chrysophsin-3 killed B. anthracis even in its sporulated state while more killing was observed for germinated and vegetative states. The elasticity of vegetative B. anthracis increased from 12 ± 6 to 84 ± 17 MPa after exposure to 0.22 mM chrysophsin-3. An increase in cellular spring constant was also observed for chrysophsin-3-treated vegetative B. anthracis. Atomic force microscopy images suggested that the changes in mechanical properties of vegetative B. anthracis after chrysophsin-3 treatment are due to loss of water content and cellular material from the cell, possibly caused by the disruption of the cell membrane by the AMP. In contrast, sporulated and germinated B. anthracis retained their innate mechanical properties. Our data indicate that chrysophsin-3 can penetrate the spore coat of B. anthracis spores and kill them without causing any significant mechanical changes on the spore surface. These results reveal a yet unrecognized role for chrysophsin-3 in the killing of B. anthracis spores without the need for complete germination or release of spore coats.
The presence of more than two index adenomas is the strongest predictor of metachronous colon adenomas (2002)

To assess whether patient or adenoma characteristics at index colonoscopy could be predictors of metachronous adenomas and of advanced metachronous adenomas at first surveillance colonoscopy.This retrospective study evaluated polypectomies of 372 adenomas in 214 patients who underwent a first follow-up colonoscopy after a median of 17 months. Logistic regression analysis was used to assess the association of baseline patient and adenoma characteristics with the development of any metachronous adenomas and of advanced adenomas (>1.0 cm, or villous component, or severe dysplasia, or early cancer).Eighty-one patients (38%) demonstrated 130 metachronous adenomas including 21 cases (10%) with advanced adenomas. The presence of more than 2 baseline adenomas was significantly associated with the finding of adenomas at follow-up (odds ratio 2.44, 95% confidence interval 1.27-4.68, p = 0.010). Patient age (>or= 60 versus <60) and size of largest adenoma (>1.0 cm versus <or= 1.0 cm) demonstrated borderline significance. However, neither gender, most advanced histology (tubulo-villous/villous versus tubular), nor most advanced dysplasia (severe/early cancer versus mild/moderate) at baseline colonoscopy were related with the development of metachronous adenomas. Furthermore, none of the analysed patient and polyp characteristics demonstrated an association with the development of advanced metachronous adenomas.Patients with over 2 adenomas at baseline colonoscopy are at highest risk for the finding of adenomas at follow-up.
High yield silicon photonic crystal microcavity biosensors with 100fM detection limit (2013)

We experimentally demonstrated a silicon photonic crystal (PC) microcavity biosensor with 50 femto-molar detection limit. Our devices have demonstrated sensitivities higher than than competing optical platforms at concentration of 0.1&mu;g/ml across a range of dissociation constants KD 1 micro-molar to 1 femto-molar. High sensitivities were achieved by slow light engineering which reduced the radiation loss and increased the stored energy in the PC microcavity resonance mode which contributed to high Q as well as enhanced optical mode overlap with the analyte. By integrating subwavelength grating coupler, we showed that not only coupling efficiency increased but also the working device yield significantly improved
Effect of cytochalasin B and demecolcine on freeze–thaw survival of murine embryos in vitro (1986)

The effects of cytochalasin B (CB), a microfilament inhibitor, and demecolcine (DC), a microtubule inhibitor, on freeze-thaw survival and culture survival of early cleavage stage mouse embryos, was evaluated. In the first experiment, eight-cell mouse embryos were frozen in dimethylsulfoxide (DMSO) or DMSO + 0.1 microgram/ml DC + 7.5 micrograms/ml CB. In the second experiment, eight-cell embryos were dehydrated and cultured in the presence of either DMSO, DMSO + DC, DMSO + CB, or DMSO + DC + CB for 45 min prior to rehydration and culture to stimulate the osmotic and chemical changes encountered during the dehydration and rehydration procedures, but without the consequences of freezing and thawing. In the third experiment, additional eight-cell embryos were frozen in either DMSO, DMSO + DC, DMSO + CB, or DMSO + DC + CB. The survival of embryos frozen in DMSO (75%) was significantly higher (P less than 0.01) than that of embryos frozen in DMSO + DC + CB (55%). No differences (P = 0.55) were observed after a 48-hr culture period in the development of embryos dehydrated, cultured, and rehydrated but not frozen. Embryos frozen in the presence of both DC and CB had a lower (P = 0.06) survival rate (55%) than that of embryos frozen in the presence of DMSO, DC, or CB (approximately 70%). These results suggest that both microfilaments and microtubules have a role in maintaining the structural integrity of the plasma membrane during the freeze-thaw process and that the loss of either loss does not seem to be detrimental to survival, but the loss of both results in lower survival.
Increased activity of plasminogen activators during involution of the rat ventral prostate (1984)

Plasminogen activator was measured in the ventral prostates of non-castrated, castrated, and androgen-treated rats to determine whether changes in this activity correlated with the process of glandular involution. While the activity was very low in cytosolic extracts from the prostates of non-castrated rats, 2 days following castration the plasminogen activator activity increased in a near-linear fashion such that by day 7 it was 10-fold higher in terms of specific activity (per mg of protein) and cellular concentration (per mg of DNA). During this interval there was a rapid decrease in the cell population of the prostates. Treatment of the 7-day castrated rats with the potent androgen, dihydrotestosterone, both reduced the plasminogen activator activity and restored the cell number in a dose-related manner. Gel electrophoretic analysis revealed two major bands of plasminogen activator activity in the cytosolic extracts from 4- and 7-day castrated rats, plus additional minor bands in samples from 10- and 14-day castrated rats. Approx. 10% of the cellular concentration of plasminogen activator activity was recovered in association with an 18000g pellet fraction from the prostates; this fraction showed less heterogeneity of the plasminogen activator forms as observed by gel electrophoresis. Inhibitor studies indicated that the 18000g pellet fraction from the prostates of non-castrated rats possessed some plasminogen activator inhibitor activity, but the relative concentration of the inhibitor activity was small. We conclude that the involution of the prostate is probably associated with increased synthesis of plasminogen activators through a de-repression process which may involve loss of androgen receptors.
Yersinia ruckeri —A threat not only to rainbow trout (2019)

Yersinia ruckeri (Y. ruckeri) can cause mortalities that are contributing to substantial economic losses in the rainbow trout (Oncorhynchus mykiss) aquaculture sector. Because of its most characteristic clinical signs, the disease in rainbow trout caused by this pathogen is called enteric redmouth disease. Although it is considered to affect mainly salmonids, there are reports in the available literature of isolating this bacterium from other fish species, both clinically healthy and diseased. The aim of this study was to analyse the available data concerning yersiniosis in non-salmonid fish. The analysed data indicate that Y. ruckeri is a threat not only to rainbow trout. Some of the affected species have high commercial importance and mortalities may contribute to high economic losses. The disease symptoms may not be specific and can be different from those characteristic for enteric redmouth in trout, which may lead to misdiagnosis. Collected information indicates that infection with Y. ruckeri should be taken into account in the diagnostic procedures not only in salmonids.
Respiratory Syncytial Virus Isolation by Combined Continuous Flow-Isopycnic Banding Centrifugation (1967)

A new zonal centrifuge rotor (B-IX) which combines continuous sample flow centrifugation with isopycnic banding has been used to isolate and concentrate respiratory syncytial virus from liter volumes of culture fluid. This isolation technique utilizes a sucrose density gradient to trap and isopycnically band the virus particles, and permits recovery of the particles from the rotor in an unaggregated condition.
ChemInform Abstract: Chemical and Enzymatic Synthesis of Modified Sialyl Lewis X Tetrasaccharides with High Affinity for E and P‐Selectin. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Ventricular remodeling in ischemic heart failure stratifies responders to stem cell therapy (2019)

Response to stem cell therapy in heart failure is heterogeneous, warranting a better understanding of outcome predictors. This study assessed left ventricular volume, a surrogate of disease severity, on cell therapy benefit. Small to large infarctions were induced in murine hearts to model moderate, advanced, and end-stage ischemic cardiomyopathy. At 1 month postinfarction, cardiomyopathic cohorts with comparable left ventricular enlargement and dysfunction were randomized 1:1 to those that either received sham treatment or epicardial delivery of cardiopoietic stem cells (CP). Progressive dilation and pump failure consistently developed in sham. In comparison, CP treatment produced significant benefit at 1 month post-therapy, albeit with an efficacy impacted by cardiomyopathic stage. Advanced ischemic cardiomyopathy was the most responsive to CP-mediated salvage, exhibiting both structural and functional restitution, with proteome deconvolution substantiating that cell therapy reversed infarction-induced remodeling of functional pathways. Moderate cardiomyopathy was less responsive to CP therapy, improving contractility but without reversing preexistent heart enlargement. In end-stage disease, CP therapy showed the least benefit. This proof-of-concept study thus demonstrates an optimal window, or "Goldilocks principle," of left ventricular enlargement for maximized stem cell-based cardiac repair. Disease severity grading, prior to cell therapy, should be considered to inform regenerative medicine interventions.
Search for a light pseudoscalar Higgs boson in the boosted μμττ final state in proton-proton collisions at $$ \sqrt{s} $$ = 13 TeV (2020)

A bstract A search for a light pseudoscalar Higgs boson (a) decaying from the 125 GeV (or a heavier) scalar Higgs boson (H) is performed using the 2016 LHC proton-proton collision data at $$ \sqrt{s} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msqrt> <mml:mi>s</mml:mi> </mml:msqrt> </mml:math> = 13 TeV, corresponding to an integrated luminosity of 35 . 9 fb − 1 , collected by the CMS experiment. The analysis considers gluon fusion and vector boson fusion production of the H, followed by the decay H → aa → μμττ , and considers pseudoscalar masses in the range 3 . 6 &lt; m a &lt; 21 GeV. Because of the large mass difference between the H and the a bosons and the small masses of the a boson decay products, both the μμ and the ττ pairs have high Lorentz boost and are collimated. The ττ reconstruction efficiency is increased by modifying the standard technique for hadronic τ lepton decay reconstruction to account for a nearby muon. No significant signal is observed. Model-independent limits are set at 95% confidence level, as a function of m a , on the branching fraction (ℬ) for H → aa → μμττ , down to 1 . 5 (2 . 0) × 10 − 4 for m H = 125 (300) GeV. Model-dependent limits on ℬ(H → aa) are set within the context of two Higgs doublets plus singlet models, with the most stringent results obtained for Type-III models. These results extend current LHC searches for heavier a bosons that decay to resolved lepton pairs and provide the first such bounds for an H boson with a mass above 125 GeV.
ChemInform Abstract: SYNTHESIS AND CHARACTERIZATION OF OSMIUM PORPHYRINS (1985)

Abstract Os 3 (CO) 12 reagiert mit den Porphyrinbasen in Monoglyme unter Rückfluß (8 h) zu den Os(II)‐Komplexen (I), die durch Auflösen in einem Donatorlösungsmittel nach Zugabe von Hexan (IIa) und (IIb) in nahezu quantitativer Ausb. liefern.
Deux objets inscrits de Tell Tweini (2012)

L'article prÃ©sente deux sceaux inscrits qui proviennent des fouilles belges de Tell Tweini. Les inscriptions sont Ã©crites en louvite hiÃ©roglyphique et datent du 13e siÃ¨cle av. J.-C.
Efficiency measurement of UWB and UHF antennas in small cavities of arbitrary shape (2009)

Abstract A new method that extends the application of spherical Wheeler cap to relatively small cavities of any shape is presented for radiation efficiency estimation. We introduce a modified Huynh formulation to take into account cavity losses when they are non‐negligible for high frequencies. These assumptions are consistent with experimental results, which are based on antenna measurements in cubic cavities and for different frequency bands. © 2009 Wiley Periodicals, Inc. Microwave Opt Technol Lett 51: 2193–2196, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.24552