gebhart/patrepeval huggingface dataset:
The First Extracellular Domain of Corticotropin Releasing Factor-R1 Contains Major Binding Determinants for Urocortin and Astressin* (1998)

The CRF receptors are members of a 7-transmembrane receptor family that includes GH-releasing hormone (GRF), calcitonin, vasoactive intestinal peptide (VIP), secretin, and PTH receptors. To determine the structural features of the CRF receptor that may influence ligand recognition, a series of mutant receptors was analyzed for binding to astressin, a CRF antagonist, and to urocortin, a CRF agonist. Mutant receptors included chimeras between the CRF-R1 and GRF-R or Activin IIB-R, a single membrane spanning receptor serine/threonine kinase. Binding to the mutant receptors was assessed using 125I-[DTyr1] astressin (Ast*) and 125I-[Tyr0]-rat urocortin (Ucn*). There was no binding to a chimeric receptor in which the first extracellular domain (E1c) (i.e. the N-terminal region) of the CRF-R1 was replaced by that of the GRF-R. The complementary chimera in which E1 domain of the GRF-R was replaced by that of the CRF-R1 bound astressin and urocortin with Ki values approximately 10 nM, compared with inhibitory binding dissociation constant (Ki) values of approximately 2-4 nM for the wild-type CRF-R1. The chimera in which E1 of the activin IIB receptor was replaced by E1 of the CRF-R1 bound astressin with a Ki approximately 4 nM. A chimera in which both the first and fourth extracellular domains of the CRF-R1 replaced the corresponding domains of the GRF-R bound astressin with Ki approximately 4 nM and urocortin with a Ki approximately 2 nM. A chimera in which all four extracellular domains of the CRF receptor replaced those of the GRF-R bound astressin and urocortin with Ki values approximately 4 nM and approximately 1 nM, respectively. In conclusion, the major determinants for high affinity binding of CRF agonists and antagonists to CRF-R1 are found in the first extracellular domain of the receptor.
Comparison of Intra-arterial and Intravenous Infusion of Cisplatin for Head and Neck Squamous Cell Carcinoma in a Modified Rat Model (1993)

To study intra-arterial infusion of chemotherapeutic agents, human squamous carcinoma cells were obtained from the FaDu cell line and were implanted in athymic rats (rnu/rnu). The xenografts were grown and then were reimplanted on a vascular pedicle and were completely isolated from the surrounding tissue. The vascular isolation of these pedicles was confirmed radiographically and histologically. After 26 days of growth, an osmotic pump was implanted to deliver either saline, intra-arterial cisplatin, or intravenous cisplatin to the vascular pedicle. Platinum levels were identified in the tumors following intra-arterial and intravenous infusions, demonstrating the usefulness of this model for delivery of antineoplastic agents. We were unable to detect differences between tumor groups for final tumor volume, tumor platinum levels, and tumor histology with the one-dose schedule used. We were able to show a remarkable uniformity of the tumor platinum levels with varying serum platinum levels with intra-arterial and intravenous infusion of cisplatin. The toxicity of each drug administration method was assessed by levels of renal platinum and rat serum creatinine and blood urea nitrogen. No differences in toxicity with the dose administrated. We believe the immunodeficient rat with a xenografted isolated vascular pedicle is an excellent model to study the effect of intra-arterial therapeutic modalities on head and neck squamous cell carcinoma.
MR‐assisted PET respiratory motion correction using deep‐learning based short‐scan motion fields (2022)

An MRI-assisted PET MoCo method was evaluated using the ground truth in a phantom study. In patients with hepatic lesions, PET MoCo images improved quantitative and qualitative metrics based on only 30-40 s of MRI motion modeling data.
Supplementary Figure 6 from Reducing TNF Receptor 2<sup>+</sup> Regulatory T Cells via the Combined Action of Azacitidine and the HDAC Inhibitor, Panobinostat for Clinical Benefit in Acute Myeloid Leukemia Patients (2023)

&lt;p&gt;PDF file - 2213K, The effect of treatment drugs on TNFR2, CD25 and FOXP3 expression as well as on intracellular cytokine production.&lt;/p&gt;
Characterization of arsenic dose loss at the Si/SiO2 interface (2000)

Careful sample preparation and secondary ion mass spectroscopy have been used to characterize arsenic dose loss to the silicon–oxide interface. Using high resolution x-ray photoelectron spectroscopy for microprofiling, we have directly observed the pileup of arsenic at the silicon dioxide–silicon interface. At least half of the pileup is shown to be on the silicon side of the interface in the first monolayer of silicon. Monolayer chemical oxidation and etching are successfully used to profile this pileup in silicon. This pileup contains most of the arsenic dose loss that occurs during transient enhanced diffusion. This result is crucial to correctly model the dose loss and provides physical justification for using a trap/detrap model at the interface, which is necessary to account for the fact that the arsenic surface concentration remains constant during an anneal and the fact that the dose loss is partially reversible. Finally, we have found that normal etching of the oxide in dilute hydroflouric acid and subsequent rinsing in water and exposure to air causes a permanent loss in arsenic dose.
Transcriptional regulation by iron of the gene for the transferrin receptor. (1986)

Treatment of K562 cells with desferrioxamine, a permeable iron chelator, led to an increase in the number of transferrin receptors. Increasing intracellular iron levels by treatment of cells with either human diferric transferrin or hemin lowered the level of the transferrin receptors. By using a cDNA clone of the human transferrin receptor, we showed that the changes in the levels of the receptor by iron were accompanied by alterations in the levels of the mRNA for the receptor. The rapidity of these changes indicated that the mRNA had a very short half-life. By using an in vitro transcriptional assay with isolated nuclei, we obtained evidence that this regulation occurred at the transcriptional level.
Oxygen as a reagent gas for the analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin by negative ion chemical ionization mass spectrometry (1975)

Under negative ion chemical ionization conditions, the radical anion of tetrachlorodibenzo-p-dioxin (TCDD) undergoes a novel reaction with oxygen to produce an ion which is characteristic of structure and easily identified in the presence of other halogenocarbon contaminants.
X-shaped third harmonic generated by ultrashort infrared pulse filamentation in air (2008)

The authors report the measurement of the angularly resolved spectrum of the third harmonic generated in a femtosecond filament in air and its evolution with increasing pump power. Pumped by a focused infrared ultrashort pulse with a carrier wavelength of 1270nm, a pulse duration of ∼20fs, and pulse energy up to 487μJ, the generated third harmonic is composed of an on-axis emission and a conical ring emission. When the pump power is sufficiently high, angularly resolved spectra with significant X-like feature could be observed, indicating the formation of nonlinear X wave at third harmonic.
Erratum to "IL8 and serum soluble TRAIL levels following anti-VEGF monoclonal antibody treatment in patients with metastatic colon cancer" [Clin. Lab. 2012; 58:501-505]. (2012)

In BevacizumAb therapy, serum IL8 levels were decreased in all patients, and thus, changes in such levels were not correlated with disease outcome. Our data suggest measurement of changes in sTRAIL following BevacizumAb treatment may have prognostic value in metastatic colon cancer patients.
Analysis of Saturated Belief Propagation Decoding of Low-Density\n Parity-Check Codes (2014)

We consider the effect of log-likelihood ratio saturation on belief\npropagation decoder low-density parity-check codes. Saturation is commonly done\nin practice and is known to have a significant effect on error floor\nperformance. Our focus is on threshold analysis and stability of density\nevolution.\n We analyze the decoder for standard low-density parity-check code ensembles\nand show that belief propagation decoding generally degrades gracefully with\nsaturation. Stability of density evolution is, on the other hand, rather\nstrongly effected by saturation and the asymptotic qualitative effect of\nsaturation is similar to reduction by one of variable node degree.\n We also show under what conditions the block threshold for the saturated\nbelief propagation corresponds with the bit threshold.\n
Validity of Double and Triple Gaussian Functions for Proximity Effect Correction in X-ray Mask Writing (1996)

An improved function is proposed to express the deposited energy intensity distribution for fine patterns or that for heavy metals such as X-ray absorbers. An experimental method is also proposed for obtaining the function parameters, and the optimal parameters are obtained for Si and W–Ti substrates at acceleration voltage of 25 kV. Using the improved function with the best-fit parameters, the validity of the double and triple Gaussian functions for the proximity effect correction is evaluated. The dose modulation ratios for ninety line-and-space patterns on the two substrates are calculated using the double Gaussian, triple Gaussian, and improved functions. From the comparison among the ratios, the following are found: for the double Gaussian function the ranges of correction errors on W–Ti and Si substrates are 8 and 30%, respectively; for the triple Gaussian function the ranges of errors on W–Ti and Si substrates are 6 and 12%, respectively.
Supplementary Table 1 from Combinations with Allosteric SHP2 Inhibitor TNO155 to Block Receptor Tyrosine Kinase Signaling (2023)

&lt;p&gt;The activity of nazartinib, TNO155, and their combination in EGFR mutant NSCLC cell lines.&lt;/p&gt;
Induction of Apoptotic Cell Death by Cordycepin, an Active Component of the Fungus Cordyceps militaris, in AGS Human Gastric Cancer Cells (2016)

Nucleoside adenosine 유도체의 하나인 cordycepin (3&#x2032;-deoxyadenosine)은 Cordyceps 속에서 유래된 활성 물질 중의 하나로서 항염증, 항산화 및 항암활성을 포함한 다양한 약리학적 효능이 있는 것으로 잘 알려져 있다. 본 연구에서는 AGS 인체 위암세포의 증식에 미치는 cordycepin의 영향과 관련 기전 연구를 시도하였다. Cordycepin의 처리에 따라 AGS 세포의 생존율이 처리 농도 의존적으로 감소되었으며, DNA 단편화 및 flow cytometery 분석에 따른 apoptosis 유발 또한 유의적으로 증가하였음을 확인하였다. 이러한 cordycepin 처리에 따른 AGS 세포의 apoptosis 유도에는 TRAIL, DR5 및 FasL의 mRNA 및 단백질의 발현 증가가 연관되어 있었다. 아울러 cordycepin은 Bcl-2 family 중 pro-apoptotic 인자인 Bax의 발현은 증가시켰으며, anti-apoptotic 인자인 Bcl-2 및 Bcl-xL의 발현은 전사 및 번역 수준에서 억제시켰다. 이러한 현상들은 extrinsic 및 intrinsic apoptosis의 initiator caspase (caspase-8 및 -9) 뿐만 아니라 effector caspase인 caspase-3의 활성과 PARP 단백질의 절단 증가와 연관성이 있었다. 따라서 AGS 세포에서 cordycepin에 의한 apoptosis의 유발은 death receptor 활성과 mitochondria 기능 손상을 포함한 multiple apoptotic pathway가 관여할 것으로 생각된다. 비록 좀 더 세심한 기전 연구의 결과가 뒤따라야 되겠지만, 본 연구의 결과는 cordycepin의 항암작용을 이해하는데 중요한 자료가 될 것이며 향후 수행될 추가 실험을 위한 기초 자료로서 그 가치가 매우 높을 것으로 생각된다. Cordycepin, a derivative of the nucleoside adenosine, is one of the active components extracted from fungi of genus Cordyceps, and has been shown to have many pharmacological activities. In this study, we investigated the effects of cordycepin on proliferation and apoptosis of human gastric cancer AGS cells, and its possible mechanism of action. Treatment of cordycepin resulted in significant decrease in cell viability of AGS cells in a concentration-dependent manner. A concentration-dependent apoptotic cell death was also measured by agarose gel electrophoresis and flow cytometery analysis. Molecular mechanistic studies of apoptosis unraveled cordycepin treatment resulted in an enhanced expression of tumor necrosis factor-related apoptosis-inducing ligand, death receptor 5 and Fas ligand. Furthermore, up-regulation of pro-apoptotic Bax, and down-regulation of anti-apoptotic Bcl-2 and Bcl-xL expression were also observed in cordycepin-treated AGS cells. These were followed by activation of caspases (caspase-9, -8 and -3), subsequently leading to poly (ADP-ribose) polymerase cleavage. Taken together, these findings indicate that cordycepin induces apoptosis in AGS cells through regulation of multiple apoptotic pathways, including death receptor and mitochondria. Although further mechanical studies are needed, our results revealed that cordycepin can be regarded as a new effective and chemopreventive compound for human gastric cancer treatment.
Placenta percreta and the urologist. (2009)

Placenta percreta, the rarest and most severe form of placenta accreta, can involve the urinary bladder. Because of its propensity for severe hemorrhage, it is a potentially life-threatening condition. Although commonly discovered at the time of delivery, antenatal diagnosis may be achieved with ultrasound, magnetic resonance imaging, and/or cystoscopy. Every attempt should be made to minimize potential for blood loss by avoiding removal of the placenta at the time of delivery and either performing a hysterectomy or using methotrexate therapy to ablate the residual placenta in the postpartum period. If hemorrhage does occur during delivery, immediate surgical removal of the uterus should be considered and, depending on the severity of the hemorrhage and the depth of invasion of the placenta into the bladder, excision and/or reconstruction of the bladder may be necessary.
High temperature thermoelectrics (2023)

In accordance with one embodiment of the present disclosure, a thermoelectric device includes a plurality of thermoelectric elements that each include a diffusion barrier. The diffusion barrier includes a refractory metal. The thermoelectric device also includes a plurality of conductors coupled to the plurality of thermoelectric elements. The plurality of conductors include aluminum. In addition, the thermoelectric device includes at least one plate coupled to the plurality of thermoelectric elements using a braze. The braze includes aluminum.
Had better, 'd better and better: diachronic and transatlantic variation (2013)

peer reviewed
Measurement of interferometric autocorrelations: comment (1997)

Conventional Michelson interferometers that are widely used for autocorrelation of ultrashort optical pulses are incapable of producing two identical replicas of an optical pulse, hence yielding a correct autocorrelation signal. The problem is acute when one records the interferometric autocorrelation of pulses consisting of just a few optical cycles. With the use of sub-10-fs pulses we demonstrate asymmetric autocorrelation traces recorded with a conventional Michelson interferometer, refer to previously reported results that exhibit the same deficiency, and elucidate the origin of the problem. A simple modification of the conventional interferometer configuration yields the correct fringe-resolved autocorrelation trace.
Radical polymerization of mono‐ and di‐methacrylic esters containing bisphenol‐S (1993)

Abstract Radical polymerizations of mono‐ and di‐methacrylic esters containing bisphenol‐S (BPS‐M and BPS‐DM) were studied in terms of polymerization rate, solvent effect, copolymerization and kinetic measurements of photocrosslinking. The solvents were found to affect significantly the polymerization rate. Polar solvents such as DMSO and acetonitrile were found to slow down the polymerization rate. Copolymerization of BPS‐M(M 1 ) with MMA(M 2 ) was studied in acetone at 60°C. The monomer reactivity ratios were calculated to be r 1 = 3.72 ± 0.01 and r 2 = 0.80 ± 0.01 by the Fineman‐Ross method. The high reactivity of BPS‐M observed in this copolymerization system may be due to the “matrix effect”. Functional polymers containing methacrylate side‐groups were successfully modified and photocrosslinked by irradiation in the presence of benzoin isopropyl ether. The photocrosslinking process is found to be of second order kinetics.
Uniformly spaced λ/4-shifted Bragg grating array with wafer-scale CMOS-compatible process (2013)

We report on an integrated λ/4-shifted Bragg grating array using a wafer-scale complementary metal-oxide semiconductor (CMOS) compatible process with silicon-nitride waveguides. A sidewall grating was used to simplify the fabrication process, and a sampled Bragg grating with equivalent phase-shift structure was employed to achieve an accurate λ/4 phase shift. A four-channel λ/4-shifted Bragg grating array with highly uniform channel spacing was demonstrated with a measured channel spacing variation below 10 pm (1.25 GHz). The high channel-spacing uniformity and the CMOS-compatibility of the demonstrated device hold promise for integrated distributed feedback laser arrays for various silicon photonic applications.
Microwave generation using an integrated hybrid silicon mode-locked laser in a coupled optoelectronic oscillator configuration (2013)

We demonstrate the feasibility of using a hybrid silicon mode-locked laser in a coupled optoelectronic oscillator configuration for generating low phase noise 20-GHz microwave signal. The free-running oscillator has a 3dB RF linewidth of 14kHz.
Hypoxia-selective antitumor agents. 4. Relationships between structure, physicochemical properties, and hypoxia-selective cytotoxicity for nitracrine analogs with varying side chains: the "iminoacridan hypothesis" (1990)

The nitroacridine derivative nitracrine is a potent hypoxia-selective cytotoxin for mammalian cells in culture. In an attempt to modulate the degree of hypoxia selectivity among this class of compounds, we have studied a series of side-chain analogues of nitracrine. Both the electronic and steric properties of the side chain are shown to be important in determining the hypoxia selectivity of the compounds, by controlling the degree of aminoacridine/iminoacridan tautomerism. Studies with the repair-defective Chinese hamster cell line UV4 indicate that the cytotoxicity of all the compounds is due to nitro group reduction and subsequent macromolecular adduct formation. However, compounds such as the 9-amino derivative, which exist totally as the aminoacridine tautomer, form much less lethal lesions than the 9-alkylamino derivatives, which exist to varying degrees in the iminoacridan conformation. For the whole set of compounds, the degree of hypoxia-selective cytotoxicity correlates well with the proportion of iminoacridan tautomer present.
Supplementary Table 3 from SMAD4 Loss in Colorectal Cancer Patients Correlates with Recurrence, Loss of Immune Infiltrate, and Chemoresistance (2023)

&lt;p&gt;Distribution of colorectal cancer cases according to SMAD4 expression status and immune response to the tumor in validation cohort&lt;/p&gt;
Intraventricular Implant of Encapsulated CNTF-Secreting Fibroblasts Ameliorates Motor Deficits in Aged Rats (2008)

The impact of intraventricular ciliary neurotrophic factor (CNTF) on motor function in aged rats was evaluated. Spontaneous locomotion and motor coordination were quantified in young (5-6 months) and aged (24-25 months) rats. Relative to young animals, aged rats were significantly less active, fell more rapidly from a rotating rod, and were unable to maintain their balance on a wooden beam. Aged animals received bilateral intraventricular implants of polymer-encapsulated fibroblasts that were genetically modified to secrete CNTF. Controls received either no implant or capsules loaded with mock transfected cells. One month after implantation the aged animals that received CNTF implants were significantly more active and were improved on the rotorod and beam balance tests. The improvement in performance on the rotorod and beam balance tests was dependant on the task difficulty and dissipated at higher rotations (rotorod) and smaller beam widths (beam balance). No recovery was seen in aged animals receiving control implants. Postmortem removal of the encapsulated cells confirmed that they continued to secrete CNTF. These data are the first to suggest that intracerebral delivery of CNTF might be useful for slowing or reversing age-related changes in motor function.
Image-based registration for synthetic aperture holography (2011)

High pixel count apertures for digital holography may be synthesized by scanning smaller aperture detector arrays. Characterization and compensation for registration errors in the detector array position and pitch and for phase instability between the reference and object field is a major challenge in scanned systems. We use a secondary sensor to monitor phase and image-based registration parameter estimators to demonstrate near diffraction-limited resolution from a 63.4 mm aperture synthesized by scanning a 5.28 mm subaperture over 144 transverse positions. We demonstrate 60 μm resolution at 2 m range.
Use of an automatic analyzer for bipolar cardiac electrograms (2003)

A program (AP) for automatically picking (detecting and timing) local activations in bipolar cardiac electrograms has been developed. The program is used in mapping the activation sequence of the heart during normal rhythms and ventricular arrhythmias, particularly ventricular tachycardia and ventricular fibrillation, in experimental and clinical environments. The difficult conditions under which the program can be applied, the lack of technical background of many of the system's users, and the nature of the programs which are used in conjunction with the detector required careful design of the software. The design constraints observed during the development of AP and how the system has been integrated with the rest of the hardware and software of the mapping system used in the authors' laboratory are described.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Modeling, Analysis, and Design of Stationary-Reference-Frame Droop-Controlled Parallel Three-Phase Voltage Source Inverters (2012)

Power-electronics-based microgrids (MGs) consist of a number of voltage source inverters (VSIs) operating in parallel. In this paper, the modeling, control design, and stability analysis of parallel-connected three-phase VSIs are derived. The proposed voltage and current inner control loops and the mathematical models of the VSIs are based on the stationary reference frame. A hierarchical control scheme for the paralleled VSI system is developed comprising two levels. The primary control includes the droop method and the virtual impedance loops, in order to share active and reactive powers. The secondary control restores the frequency and amplitude deviations produced by the primary control. Also, a synchronization algorithm is presented in order to connect the MG to the grid. Experimental results are provided to validate the performance and robustness of the parallel VSI system control architecture.
DeepVisage: Making face recognition simple yet with powerful generalization skills (2017)

Face recognition (FR) methods report significant performance by adopting the convolutional neural network (CNN) based learning methods. Although CNNs are mostly trained by optimizing the softmax loss, the recent trend shows an improvement of accuracy with different strategies, such as task-specific CNN learning with different loss functions, fine-tuning on target dataset, metric learning and concatenating features from multiple CNNs. Incorporating these tasks obviously requires additional efforts. Moreover, it demotivates the discovery of efficient CNN models for FR which are trained only with identity labels. We focus on this fact and propose an easily trainable and single CNN based FR method. Our CNN model exploits the residual learning framework. Additionally, it uses normalized features to compute the loss. Our extensive experiments show excellent generalization on different datasets. We obtain very competitive and state-of-the-art results on the LFW, IJB-A, YouTube faces and CACD datasets.