gebhart/patrepeval huggingface dataset:
Osmotic flow effects on the dialysis escape curves of solutes (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOsmotic flow effects on the dialysis escape curves of solutesDien-Feng. Shieh, Jan. Feijen, and Donald J. LymanCite this: Anal. Chem. 1975, 47, 7, 1186–1188Publication Date (Print):June 1, 1975Publication History Published online1 May 2002Published inissue 1 June 1975https://pubs.acs.org/doi/10.1021/ac60357a045https://doi.org/10.1021/ac60357a045research-articleACS PublicationsRequest reuse permissionsArticle Views36Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Modified three‐dimensional self‐complementary array antenna over a finite ground plane (1983)

Abstract A balanced wideband antenna based on the self‐complementary principle is known as a log‐periodic antenna. Another type of self‐complementary antenna, the unbalanced type, has not been extensively studied, even though it is useful in many areas, including mobile communication. This paper describes an unbalanced wideband antenna with an extremely simple structure based on the principle of the three‐dimensional self‐complementary antenna. A method for deriving a unidirectional and constant‐impedance antenna from a three‐dimensional self‐complementary antenna having several symmetrical radiation lobes is proposed, and a theoretical and experimental analysis of the radiation characteristics of a monopole‐slot pair with a finite ground plane is given. It is shown that the radiation characteristics remain almost unchanged when the ground plane is larger than one wavelength in four directions from the center of the antenna pair. It is also shown that the gain in the maximum radiation direction of an element pair is much higher on a semi‐infinite ground plane than on an infinite ground plane. A wide‐band antenna consisting of element‐pairs spaced at equal intervals and with a length taper is described. the antenna exhibits a substantial array effect on the gain. the gain is higher than that of a monopole‐notch array antenna with a ground plane.
Preliminary evaluation of a micro-force sensing handheld robot for vitreoretinal surgery (2012)

Highly accurate positioning is fundamental to the performance of vitreoretinal microsurgery. Of vitreoretinal procedures, membrane peeling is among the most prone to complications since extremely delicate manipulation of retinal tissue is required. Associated tool-to-tissue interaction forces are usually below the threshold of human perception, and the surgical tools are moved very slowly, within the 0.1-0.5 mm/s range. During the procedure, unintentional tool motion and excessive forces can easily give rise to vision loss or irreversible damage to the retina. A successful surgery includes two key features: controlled tremor-free tool motion and control of applied force. In this study, we present the potential benefits of a micro-force sensing robot in vitreoretinal surgery. Our main contribution is implementing fiber Bragg grating based force sensing in an active tremor canceling handheld micromanipulator, known as Micron, to measure tool-to-tissue interaction forces in real time. Implemented auditory sensory substitution assists in reducing and limiting forces. In order to test the functionality and performance, the force sensing Micron was evaluated in peeling experiments with adhesive bandages and with the inner shell membrane from chicken eggs. Our findings show that the combination of active tremor canceling together with auditory sensory substitution is the most promising aid that keeps peeling forces below 7 mN with a significant reduction in 2-20 Hz oscillations.
TLR8 ligation induces apoptosis of monocytic myeloid-derived suppressor cells (2017)

Myeloid-derived suppressor cells (MDSCs) accumulate in tumors and the peripheral blood of cancer patients and demonstrate cancer-promoting activity across multiple tumor types. A limited number of agents are known to impact MDSC activity. TLR8 is expressed in myeloid cells. We investigated expression of TLR8 on MDSC and the effect of a TLR8 agonist, motolimod, on MDSC survival and function. TLR8 was highly expressed in monocytic MDSC (mMDSC) but absent in granulocytic MDSC (gMDSC). Treatment of human PBMC with motolimod reduced the levels of mMDSC in volunteers and cancer donors versus control (P < 0.001). Motolimod did not impact levels of gMDSC. The reduction of mMDSC was due to induced cell death by TLR8 ligation. Pretreatment of PBMC with a FAS neutralizing antibody inhibited motolimod-induced reduction of mMDSC (P < 0.001). Finally, we demonstrated that mMDSC impeded IL-2 secretion by CD3/CD28-activated T cells; IL-2 secretion was partially restored when cells were cocultured with motolimod (142 ± 36 pg/ml vs. 59 ± 13 pg/ml; P = 0.03). There is increasing evidence that MDSCs contribute to the progression of cancer by inhibiting tumor-directed T cells. TLR8 agonists may synergize with cancer immunotherapeutic approaches to enhance the antitumor effects of the adaptive immune response.
Nanoencapsulation of hydrophilic drug via double emulsion evaporation method (2011)

International audience
Analysis of the dynamic behaviour of magnetic gear with nonlinear modelling for large wind turbines (2016)

This article deals with the dynamic behaviour of magnetic gear. This study is based on a nonlinear analytical model of magnetic gear which gives an analytical expression of the magnetic torque for a step disturbance. From this expression, various criteria will be defined in order to reach a good performance of the magnetic gear with step or sinusoidal disturbance. These results will be compared with a nonlinear simulation. Simulations show that it is possible to have, in a transitory regime, a load angle higher than the limit load angle maintaining a coupling between the low speed and the high speed rotor. Simulations will illustrate the importance of defining design rules based on the system application domain. A high power wind turbine (MW) example is proposed. In that case studies, loads generated by wind induce strong disturbances.
Liposomal siRNA Formulations for the Treatment of Herpes Simplex Virus-1: In Vitro Characterization of Physicochemical Properties and Activity, and In Vivo Biodistribution and Toxicity Studies (2022)

Herpes simplex virus-1 (HSV-1) is highly contagious, and there is a need for a therapeutic means to eradicate it. We have identified an siRNA (siHSV) that knocks down gene expression of the infected cell protein 0 (ICP0), which is important in the regulation of HSV infection. The selected siHSV was encapsulated in liposomes to overcome its poor stability, increase cell permeability, and prolonging siRNA circulation time. Several siRNAs against ICP0 have been designed and identified. We examined the role of various parameters, including formulation technique, lipids composition, and ratio. An optimal liposomal siHSV formulation (LipDOPE-siHSV) was characterized with desirable physiochemical properties, in terms of nano-size, low polydispersity index (PDI), neutral surface charge, high siHSV loading, spherical shape, high stability in physiologic conditions in vitro, and long-term shelf-life stability (>1 year, 4 °C). The liposomes exhibited profound internalization by human keratinocytes, no cytotoxicity in cell cultures, no detrimental effect on mice liver enzymes, and a gradual endo-lysosomal escape. Mice biodistribution studies in intact mice revealed accumulation, mainly in visceral organs but also in the trigeminal ganglion. The therapeutic potential of siHSV liposomes was demonstrated by significant antiviral activity both in the plaque reduction assay and in the 3D epidermis model, and the mechanism of action was validated by the reduction of ICP0 expression levels.
A Study of Human Summaries of Scientific Articles (2020)

Researchers and students face an explosion of newly published papers which may be relevant to their work. This led to a trend of sharing human summaries of scientific papers. We analyze the summaries shared in one of these platforms Shortscience.org. The goal is to characterize human summaries of scientific papers, and use some of the insights obtained to improve and adapt existing automatic summarization systems to the domain of scientific papers.
Contract Administration: RIBA Plan of Work 2013 Guide (2015)

The RIBA Plan of Work 2013 Guide: Design Management is part of a brand new series providing must-read practical guidance to running efficient and successful projects using the new RIBA Plan of Work 2013. Each guide takes a core project task – in this case the role of the Contract Administrator - and explains the essential activities and considerations required at each stage of the new Plan of Work. 
Easy to use and navigate and in a small and handy format these guides will provide the ultimate quick reference support at your desk or on site. The author provides concise and pragmatic advice rooted in real world experience – a ‘how to’ that will resonate with practitioners. In-text features such as ‘hints and tips’, ‘checklists’, ‘forms and templates’ and ‘signposts’ to trusted resources will provide user-friendly support. Boxed examples will highlight best practice and illuminate common problems and solutions borne of hard won experience.
An Adaptive Least Angle Regression Method for Uncertainty Quantification in FDTD Computation (2018)

The nonintrusive polynomial chaos expansion method is used to quantify the uncertainty of a stochastic system. It potentially reduces the number of numerical simulations in modeling process, thus improving efficiency while ensuring accuracy. However, the number of polynomial bases grows substantially with the increase of random parameters, which may render the technique ineffective due to the excessive computational resources. To address such problems, methods based on the sparse strategy such as the least angle regression (LARS) method with hyperbolic index sets can be used. This paper presents the first work to improve the accuracy of the original LARS method for uncertainty quantification. We propose an adaptive LARS method in order to quantify the uncertainty of the results from the numerical simulations with higher accuracy than the original LARS method. The proposed method outperforms the original LARS method in terms of accuracy and stability. The L2 regularization scheme further reduces the number of input samples while maintaining the accuracy of the LARS method.
Lethal congenital contracture syndrome (LCCS) and other lethal arthrogryposes in Finland—An epidemiological study (2006)

Arthrogryposis multiplex congenita is a heterogeneous group of disorders characterized by multiple contractures with an estimated frequency of 1 in 3,000 births. With improving diagnostic methods, increasing numbers of fetuses with arthrogryposis are found. The pathogenetic mechanisms are relatively well known but the epidemiology and genetics of the prenatally lethal forms of arthrogryposis are less well known. In this study we collected all cases of a multiple contractures diagnosed in Finland during 1987-2002 including live born infants, stillbirths, and terminated pregnancies. Ninety-two cases of 214 suffered intrauterine demise (68 selective pregnancy terminations and 24 stillbirths) and 58 died in infancy. In 141 out of these cases the diagnosis could be included within lethal arthrogryposes, with a prevalence of 1 in 6,985 (1.43/10,000) births. Of these, 59 had spinal cord pathology at autopsy and thus were of neurogenic origin. Thirty-nine cases had lethal congenital contracture syndrome (LCCS) clinically characterized by total immobility of the fetus at all ultrasound examinations (12 weeks or later), multiple joint contractures in both upper and lower limbs, hydrops, and fetal death before the 32nd week of pregnancy. LCCS is noted as a unique Finnish disorder with a prevalence of 1 in 25,250 (0.40/10,000) births and is a major cause of lethal arthrogryposis in Finland.
Are First‐World Ethics Applicable to the Third World? (2005)

This chapter contains sections titled: Introduction The “90--10 Gap” Vaccine Production The Ethics of Regulatory Standards Challenging Regulatory Standards Future Strategies
Developments in memory management in OpenMP (2018)

Modern computers with multi-/many-core processors and accelerators feature a sophisticated and deep memory hierarchy, potentially including distinct main memory, high-bandwidth memory, texture memory and scratchpad memory. The performance characteristics of these memories are varied, and studies have demonstrated the importance of using them effectively. In this article, we explore some of the major issues in developing software to effectively and portably implement these technologies and describe enhancements being added to the OpenMP language to bridge this software-hardware gap. Our proposal separately exposes the characteristics of memory resources (such as kind) and the characteristics of allocations (such as alignment), and is fully compatible with existing OpenMP constructs.
Metal slot waveguide with silicon for deep subwavelength confinement and on-chip integration (2006)

We demonstrate a low loss metal slot waveguide of deep subwavelength confinement (~lambda/10) and efficient coupling with standard silicon wire waveguides for on chip integration.
Fabrication and lasing properties of mesa substrate buried heterostructure GaInAsP/InP lasers at 1.3 &#181;m wavelength (1980)

Fabrication and lasing properties of novel GaInAsP/InP injection lasers at 1.3 μm, with buried heterostructure grown on mesa substrate and fabricated by single-step crystal growth are reported. In this mesa substrate buried heterostructure (MSB) laser, the GaInAsP active layer was grown separately on the top of a mesa structure formed along the surface of a
Application of Droplet Digital PCR for Estimating Vector Copy Number States in Stem Cell Gene Therapy (2016)

Stable gene transfer into target cell populations via integrating viral vectors is widely used in stem cell gene therapy (SCGT). Accurate vector copy number (VCN) estimation has become increasingly important. However, existing methods of estimation such as real-time quantitative PCR are more restricted in practicality, especially during clinical trials, given the limited availability of sample materials from patients. This study demonstrates the application of an emerging technology called droplet digital PCR (ddPCR) in estimating VCN states in the context of SCGT. Induced pluripotent stem cells (iPSCs) derived from a patient with X-linked chronic granulomatous disease were used as clonable target cells for transduction with alpharetroviral vectors harboring codon-optimized CYBB cDNA. Precise primer-probe design followed by multiplex analysis conferred assay specificity. Accurate estimation of per-cell VCN values was possible without reliance on a reference standard curve. Sensitivity was high and the dynamic range of detection was wide. Assay reliability was validated by observation of consistent, reproducible, and distinct VCN clustering patterns for clones of transduced iPSCs with varying numbers of transgene copies. Taken together, use of ddPCR appears to offer a practical and robust approach to VCN estimation with a wide range of clinical and research applications.
Alternating Gyroid in Block Polymer Blends (2022)

Alternating gyroid is a lower symmetry variant of the double gyroid morphology, where the left-handed and right-handed chiral networks are physically distinct. This structure is of particular interest for photonic applications owing to predictions of a complete photonic band gap subject to the requirement of a large dielectric contrast between the individual networks and sufficient optical matching between one of the networks and the matrix. We provide evidence, via self-consistent field theory (SCFT), that stoichiometric blends of double-gyroid-forming AB and BC diblock copolymers with relatively immiscible A and C blocks should form an alternating gyroid morphology with complementary three-dimensional A and C networks that have a free energy that is nearly degenerate with two phase-separated double gyroid states. Solvent casting offers the potential for trapping this binary mixture of diblock copolymers in this metastable alternating gyroid phase. Theory further predicts that the addition of a minuscule amount (<1%) of ABC triblock terpolymer will open an alternating gyroid stability window in the resulting ternary-phase diagram. The surfactant-like stabilization produced by the triblock is relatively insensitive to its exact composition provided the B-block forms a sufficiently long bridge between the A-rich and C-rich networks. This blending strategy provides significant synthetic and material processing advantages compared to prevailing methods to produce an alternating gyroid phase in block polymers.
Bioremediation of copper polluted wastewater-like nutrient media and simultaneous synthesis of stable copper nanoparticles by a viable green alga (2021)

Environmentally benign, algae-mediated biosynthesis of valuable copper-based materials in wastewater, combined with cupric ion (Cu2+) bioremediation, has the potential to reduce the cost of wastewater treatment and generate high quality biosolids. This study investigated the ability of a wild-type strain of Chlamydomonas reinhardtii to bioremediate free Cu2+ in wastewater-like nutrient media during the biosynthesis of copper nanoparticles (Cu NPs). The color of supernatants from treated Cu-polluted media provided a first indication of Cu-based NPs formation in the aqueous phase. Analysis by fluorescein diacetate hydrolysis, observations of cell morphology, and algal regrowth experiments after treatment showed that algal viability was crucial for efficient Cu2+ reduction to Cu NPs. UV–vis absorption spectroscopy demonstrated that sulfur-free medium, which enables sustained hydrogen photoproduction in alga, was not the most efficient in NPs formation. Dark-field scanning transmission electron microscopy (STEM) images overlapped with Cu signal map from energy dispersive X-ray spectrometry (EDS) and high-resolution transmission electron microscopy confirmed the presence of polydisperse, spherical, and well-dispersed sub-10 nm Cu NPs crystallites exclusively in algae-treated heavily Cu-polluted media (10 mg L−1). STEM and EDS also demonstrated the affinity of Cu NPs for carbon-rich (organic) objects. Overall, this study demonstrates the feasibility of Cu2+ bioremediation from the wastewater-like complex nutrient media and the simultaneous biosynthesis of Cu NPs by viable green microalga.
New Isomalabaricane Derivatives from a New Species of Jaspis Sponge Collected at the Vanuatu Islands (2000)

Six new cytotoxic isomalabaricane-type triterpenoids and nortriterpenoids with a 3alpha-acetoxy group were isolated, along with the known globostellatic acids B (1) and C (2), from the marine sponge Jaspis sp. collected at Vanuatu Island. The structures were determined by 2D NMR data and by comparison with spectral data of known related compounds.
One-Step Synthesis for Zn2SiO4:Mn Particles 0.3–1.3 µm in Size with Spherical Morphology and Non-Aggregation (2000)

Particles of the green luminescent Zn 2 SiO 4 :Mn having size of 0.3–1.3 µm was directly prepared by spray pyrolysis without post-annealing processes. Characteristics of as-prepared particles such as crystallinity, morphology, and photoluminescence were investigated. Zn 2 SiO 4 :Mn particles with spherical morphology, non-aggregation, and having pure willemite was formed at a temperature of 1000–1300°C. The luminescence of the Mn 2+ ion in Zn 2 SiO 4 shows an emission band in the 525 nm when excited by 254 nm light.
Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity [Erratum to document cited in CA110(3):23483p] (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRetinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity [Erratum to document cited in CA110(3):23483p]Hiroyuki Kagechika, Emiko Kawachi, Yuichi Hashimoto, Koichi Shudo, and Toshiyuki HimiCite this: J. Med. Chem. 1989, 32, 12, 2583Publication Date (Print):December 1, 1989Publication History Published online1 May 2002Published inissue 1 December 1989https://pubs.acs.org/doi/10.1021/jm00132a023https://doi.org/10.1021/jm00132a023research-articleACS PublicationsRequest reuse permissionsArticle Views157Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Essential oil of Plantago asiatica upregulates the LDL receptor and represses the HMG CoA reductase expression in vitro and in vivo (2007)

Plantago asiatica essential oil (PAEO) contains multiple bioactive compounds but its potential effects on cholesterol metabolism have not been studied. The EOPA was mostly composed of oxygenated monoterpenes and linalool was the major component (82.5%, w/w) measured by liquid chromatography‐mass spectrophotometry. The PAEO (0–200 μg/ml) was incubated with HepG2 cells for 24 h and no significant toxicity was observed within the treatment conditions. We found that the PAEO incubation (50μg/ml) altered the expression of LDL receptor (+82.6 %) and HMG CoA reductase (−32.6 %) assessed by RT‐PCR. The LDL oxidation was markedly inhibited by PAEO treatment due to the prevalence of terpene compounds in PAEO. Next, we investigated effects of PAEO in vivo . Oral administration of PAEO for 3 weeks in C57BL/6 mice (PAEO 0.03 μl/mouse/day and 0.15 μl/mouse/day, respectively) significantly reduced plasma total cholesterol and triglyceride concentrations by 29 and 46%, respectively. In PAEO fed livers, mRNA levels of the LDL receptor were significantly increased (+58 %) while the mRNA and protein levels of HMG‐CoA reductase were significantly lower compared with the control groups. The CYP7A1 expression was marginally reduced in HepG2 cells but not in the mouse livers after PAEO treatment. Our data suggest that PAEO may have hypocholesterolemic effects by altering expression of the LDL receptor and HMG CoA reductase.