gebhart/patrepeval huggingface dataset:
THE INFLUENCE OF BODY MASS INDEX ON PROSTATE CANCER SCREENING IN A LARGE COHORT (2009)

You have accessJournal of Urology1 Apr 2009THE INFLUENCE OF BODY MASS INDEX ON PROSTATE CANCER SCREENING IN A LARGE COHORT Ayman S Moussa, Ahmed M Ragheb, Wei Liao, and J Stephen Jones Ayman S MoussaAyman S Moussa More articles by this author , Ahmed M RaghebAhmed M Ragheb More articles by this author , Wei LiaoWei Liao More articles by this author , and J Stephen JonesJ Stephen Jones More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(09)62153-4AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "THE INFLUENCE OF BODY MASS INDEX ON PROSTATE CANCER SCREENING IN A LARGE COHORT." The Journal of Urology, 181(4S), p. 773 © 2009 by American Urological AssociationFiguresReferencesRelatedDetails Volume 181Issue 4SApril 2009Page: 773 Advertisement Copyright & Permissions© 2009 by American Urological AssociationMetricsAuthor Information Ayman S Moussa More articles by this author Ahmed M Ragheb More articles by this author Wei Liao More articles by this author J Stephen Jones More articles by this author Expand All Advertisement PDF DownloadLoading ...
Convolutional Neural Network Based Image Steganography (2023)

In cryptography, image steganography is the activity of hiding message into an image by pixel value alteration depending upon the encryption algorithm. However, hiding images in a cover image is a great provocation today. Here Variational Auto-Encoder architecture, a type of artificial neural network is chosen which learns the maximum from the minimum dimension possible. It consists of three parts- encoder, latent space representation(compression), and decoder. It does image concealing by minimizing the loss and removing noise from the image. The secret image is first routinely embedded into the cover image by the encoding network. Then decoding network is utilized to recover the concealed image. Image Steganography using CNN has good compatibility, accuracy, and minimum loss and can be done on dissimilar data types like remote sensing images and aerial images. This model has good training and loss reduction capabilities depending upon its hyperparameters. This model is also used to train other image datasets that are diverse from this ImageNet dataset, such as remote sensing images and aerial images. This model also understands concealing and extraction ensuring secure steganography.
Abstract 4122: Multi-center validation of a lymph node metastasis gene-expression signature for head and neck squamous cell carcinomas (2011)

Abstract Background: The inability of current diagnostic tools to detect small lymph node metastases in patients with Head and Neck Squamous Cell Carcinoma (HNSCC) leads to a rate of undetected metastases that is too high to refrain from elective neck treatment, resulting in overtreatment. The aim of this study is validation of a gene expression signature for distinguishing metastasizing from non-metastasizing HNSCC on a large multi-center cohort. Material and methods: Samples of oral cavity and oropharyngeal cancer were collected from all head and neck oncological centers in the Netherlands. Gene expression was analyzed with a DNA microarray representing 696 previously reported predictive genes. The negative predictive value (NPV) was assessed on the whole cohort (n=222), on a subset including only clinically node negative (cN0) tumors (n=143) and on the most relevant subset that included T1 and T2, cN0 oral cavity tumors (n=101). Histological examination was used as gold standard for nodal status. Results: Overall, the NPV of the signature was 72 %. The signature performed better on the cN0 subset (NPV 85%) and very well in the clinically most relevant subset of T1 and T2, cN0, oral cavity SCC (NPV 89%). Conclusion: Combining the results of clinical and radiological examination with the gene expression signature decreases the rate of undetected nodal metastasis to 11 % in the relevant group of early stage cancers of the oral cavity. This result should be considered sufficient to refrain from elective neck treatment in these patients. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4122. doi:10.1158/1538-7445.AM2011-4122
Transmembrane helical interactions in the CFTR channel pore (2020)

Mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene affect CFTR protein biogenesis or its function as a chloride channel, resulting in dysregulation of epithelial fluid transport in the lung, pancreas and other organs in cystic fibrosis (CF). Development of pharmaceutical strategies to treat CF requires understanding of the mechanisms underlying channel function. However, incomplete 3D structural information on the unique ABC ion channel, CFTR, hinders elucidation of its functional mechanism and correction of cystic fibrosis causing mutants. Several CFTR homology models have been developed using bacterial ABC transporters as templates but these have low sequence similarity to CFTR and are not ion channels. Here, we refine an earlier model in an outward (OWF) and develop an inward (IWF) facing model employing an integrated experimental-molecular dynamics simulation (200 ns) approach. Our IWF structure agrees well with a recently solved cryo-EM structure of a CFTR IWF state. We utilize cysteine cross-linking to verify positions and orientations of residues within trans-membrane helices (TMHs) of the OWF conformation and to reconstruct a physiologically relevant pore structure. Comparison of pore profiles of the two conformations reveal a radius sufficient to permit passage of hydrated Cl- ions in the OWF but not the IWF model. To identify structural determinants that distinguish the two conformations and possible rearrangements of TMHs within them responsible for channel gating, we perform cross-linking by bifunctional reagents of multiple predicted pairs of cysteines in TMH 6 and 12 and 6 and 9. To determine whether the effects of cross-linking on gating observed are the result of switching of the channel from open to close state, we also treat the same residue pairs with monofunctional reagents in separate experiments. Both types of reagents prevent ion currents indicating that pore blockage is primarily responsible.
Green: A System for Supporting Energy-Conscious Programming using Principled Approximation (2009)

Energy-efficient computing is important in several systems ranging from embedded devices to large scale data centers. Several application domains offer the opportunity to tradeoff quality of service/solution (QoS) for improvements in performance and reduction in energy consumption. Programmers sometimes take advantage of such opportunities, albeit in an ad-hoc manner and often without providing any QoS guarantees. We propose a system called Green that provides a simple and flexible framework that allows programmers to take advantage of such approximation opportunities in a systematic manner while providing statistical QoS guarantees. Green enables programmers to approximate expensive functions and loops and operates in two phases. In the calibration phase, it builds a model of the QoS loss produced by the approximation. This model is used in the operational phase to make approximation decisions based on the QoS constraints specified by the programmer. The operational phase also includes an adaptation function that occasionally monitors the runtime behavior and changes the approximation decisions and QoS model to provide strong QoS guarantees. To evaluate the effectiveness of Green, we implemented our system and language extensions using the Phoenix compiler framework. Our experiments using benchmarks from domains such as graphics, machine learning, and signal processing, and a real-world web search application, indicate that Green can produce significant improvements in performance and energy consumption with small and statistically guaranteed QoS degradation.
A comparison of serotyping, BRENDA-typing and incompatibility grouping, and toxin testing of haemolyticEscherichia coliisolated from piglets before and after weaning (1986)

Abstract Before weaning, some young pigs in a research piggery excreted in their faeces a weakly haemolytic non-enterotoxigenic serotype of Escherichia coli. After weaning, all of the pigs excreted strongly haemolytic Escherichia coli of known enteropathogenic serotypes (0-138 and 0-139). The 0-138 serotype produced vero cell toxin, whilst the 0-139 serotype elaborated heat labile enterotoxin. Haemolytic enterotoxigenic E. coli were also recovered from three-week-old unweaned piglets with so-called ‘milk scours’ and from pigs with post-weaning diarrhoea on two local commercial piggeries. Selected haemolytic isolates were compared using serotyping, bacterial restriction endonuclease DNA analysis (BRENDA) and incompatibility grouping. The three typing methods divided most of the isolates into the same groupings; the exceptions were two isolates with the same BRENDA pattern and incompatibility group, but with different H-serotypes, and eleven isolates with the same serotype and BRENDA pattern but which showed differences in colony compatibility such that they were divided into five subgroups of a single incompatibility type.
Aldo-keto Reductase 1B15 (AKR1B15) (2015)

Aldo-keto reductases (AKRs) comprise a superfamily of proteins involved in the reduction and oxidation of biogenic and xenobiotic carbonyls. In humans, at least 15 AKR superfamily members have been identified so far. One of these is a newly identified gene locus, AKR1B15, which clusters on chromosome 7 with the other human AKR1B subfamily members (i.e. AKR1B1 and AKR1B10). We show that alternative splicing of the AKR1B15 gene transcript gives rise to two protein isoforms with different N termini: AKR1B15.1 is a 316-amino acid protein with 91% amino acid identity to AKR1B10; AKR1B15.2 has a prolonged N terminus and consists of 344 amino acid residues. The two gene products differ in their expression level, subcellular localization, and activity. In contrast with other AKR enzymes, which are mostly cytosolic, AKR1B15.1 co-localizes with the mitochondria. Kinetic studies show that AKR1B15.1 is predominantly a reductive enzyme that catalyzes the reduction of androgens and estrogens with high positional selectivity (17β-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoA conjugates and exhibits strong cofactor selectivity toward NADP(H). In accordance with its substrate spectrum, the enzyme is expressed at the highest levels in steroid-sensitive tissues, namely placenta, testis, and adipose tissue. Placental and adipose expression could be reproduced in the BeWo and SGBS cell lines, respectively. In contrast, AKR1B15.2 localizes to the cytosol and displays no enzymatic activity with the substrates tested. Collectively, these results demonstrate the existence of a novel catalytically active AKR, which is associated with mitochondria and expressed mainly in steroid-sensitive tissues.
Robust Discrimination of Flexion and Extension Phases for Mobile Functional Electrical Stimulation (FES) Induced Cycling in Paraplegics (2016)

A robust method for flexion and extension phase discrimination has been developed for mobile Functional electrical stimulation (FES) induced cycling by using a joint angle based stimulation pattern instead of a crank angle-based method. As a side product the crank angle and cadence can be reliably estimated. This can be used to compare the joint angle based stimulation pattern against encoder based methods or to control the smoothness of inter-cycle cadence. The proposed method was tested with a developed simulation model while applying torques at the crank to verify the robustness for mobile cycling. Finally we present the RehaBike® for the upcoming Cybathlon® competition where all methods will be integrated.
Encainide for the Treatment of Refractory Ventricular Tachycardia in Patients Undergoing Programmed Electrical Stimulation (1985)

Encainide was evaluated in 26 patients undergoing programmed electrical stimulation (PES) for ventricular arrhythmias. These patients had inducible symptomatic ventricular tachyarrhythmias during baseline PES and had previously failed a mean of 3.2 antiarrhythmic agents. Encainide was discontinued in six patients prior to PES because of spontaneous ventricular tachycardia (VT) (five patients) and adverse effect (one patient). Encainide increased, the PR, QRS, QTc intervals, and right ventricular effective refractory period (RVERP) significantly from baseline (P &lt; 0.05) in 16 patients who were extensive metabolizers. Encainide, at a mean dose of 110 ± 28 mg/day increased the ventricular tachycardia cycle length (VTCL) from 278 ± 77.1 msec to 334 ± 68.8 msec (P &lt; 0.05). Encainide alone was effective (&lt; 15 beats induced) or partially effective (converting inducible sustained VT to &lt; 15 beats asymptomatic nonsustained VT or increasing the VTCL &lt; 100 msec with no symptoms) in two and seven patients respectively. In seven patients, encainide was also reevaluated at a higher dose (mean dose 148 ± 22 mg/day), but this dose did not significantly alter the overall response or measured parameters. Seven patients were subsequently evaluated on combination of encainide and another antiarrhythmic agent. The combination was effective in three patients and partially effective in three patients. Serum concentrations were measured during each testing period; a moderate correlation was observed between the PR and RR intervals and total concentrations in patients who were extensive metabolizers. Eleven patients who were effective or partially effective during acute testing were placed on long‐term encainide therapy (three patients alone and eight patients on combination therapy). In a mean follow‐up of 8.9 months (1–25 months) encainide was discontinued in five patients (two patients due to nonsudden cardiac death, one patient due to recurrent nonfatal VT, and two patients due to side effects of combination therapy.) Conclusion: Encainide alone is minimally effective (7.7%) for preventing inducible ventricular tachycardia, but partially effective in 38.9%. Retesting at a higher dose does not offer any additional benefit. However, encainide in combination with another antiarrhythmic agent may improve the response in patients who remain inducible on encainide alone. Further studies are needed to verify this observation.
Table S2 from Longitudinal Single-Cell Dynamics of Chromatin Accessibility and Mitochondrial Mutations in Chronic Lymphocytic Leukemia Mirror Disease History (2023)

&lt;p&gt;Supplementary Table 2 - %CLL cells marked by mtDNA mutations&lt;/p&gt;
A Congestion Control Independent L4S Scheduler (2020)

In the recent years a new Internet service called Low-Latency Low-Loss Scalable-Throughput (L4S) has been proposed to provide scalable sources with ultra-low latency over the Internet, while keeping the delay and resource sharing reasonable for flows with classic loss-based congestion control. At the same time both classic and scalable congestion controls are being evolved resulting in unfair resource share among flows using different congestion controls, even within the same congestion control family. The fairness is further degraded by heterogeneous RTTs over the real-world Internet. In this paper, we show that existing L4S schedulers are not able to handle this level of heterogeneity we forecast for the future Internet. To overcome this limitation, we propose Virtual Dual Queue CSAQM that extends the Core Stateless AQM (CSAQM) concept to support L4S requirements while keeping its precise in-network control of resource sharing. We have implemented the algorithm in our DPDK-based AQM evaluation testbed and demonstrated by measurements that it performs well even in those heterogeneous cases where mainstream L4S schedulers are sub-optimal.
Corrigendum: Innate lymphoid cells are required to induce airway hyperreactivity in a murine neutrophilic asthma model (2022)

[This corrects the article DOI: 10.3389/fimmu.2022.849155.].
ALTM: Adaptive learning-based thermal model for temperature predictions in data centers (2019)

To design effective control schemes for energy efficiency in data centers, it is crucial to have a thermal model of the system. Constructing thermal models of data centers for temperature prediction is extremely challenging, due to inherent complexity. Computational fluid dynamics (CFD) simulations or physical heat transfer equations are conventionally used to construct such thermal models. More recent approaches combine physical heat transfer rules and data-driven methods in an effort to obtain more accurate models. Our proposed adaptive learning-based thermal model (ALTM) is fast, adapts to thermal changes in the data center environment, and does not require prior knowledge of heat transfer rules between data center entities. Unlike other methods, ALTM is a holistic thermal model that predicts temperature of critical zones using data center operational variables as inputs. The operational variables are the controllable parameters and easily obtained measurements from IT and cooling units. A key use case for ALTM is that it can be effectively used for thermal-aware workload schedulers or cooling system controllers. Our results confirm the accuracy and adaptability of the model.
Ultra-Strong Light-Matter Interaction with Mid-Infrared Metamaterials (2013)

We present ultra-strong light-matter interaction of a metamaterial mode and an intersubband transition for normal incidence radiation in the mid-infrared spectral region. The anti-crossed lines show a splitting of 15% of the central frequency.
Lipoteichoic acid is an important microbe-associated molecular pattern of Lactobacillus rhamnosus GG (2012)

Taken together, our results indicate that LTA of LGG is a crucial MAMP with pro-inflammatory activities such as IL-8 induction in intestinal epithelial cells and NF-κB induction in HEK293T cells via TLR2/6 interaction. The lipid chains of LGG LTA are needed for these activities, while also the D-alanine substituents are important, especially for IL-8 induction in Caco-2 cells.
Floating body CMOS phototransistor memory (2010)

An optoelectronic CMOS memory technology is proposed where photon induced floating body effect stimulates switching and hysteresis in the transistor. The floating body effect is induced by exceedingly few carriers generated by two photon absorption. In this paper we present the structure of proposing device and numerically validated the device by Atlas device simulator from SILVACO Corporation.
The HICO program - hyperspectral imaging of the coastal ocean from the international space station (2004)

The HICO (hyperspectral imager for the coastal ocean) program is a collaboration between the Naval Research Laboratory (NRL), the University of Hawai'i at Manoa, Utah State University, and NovaSol Inc., to image the coastal ocean and reef systems from the International Space Station. The first phase of the program will install the NRL portable hyperspectral imager for low light spectroscopy (PHILLS) in the Station Window Observational Research Facility (WORF), which has a nadir-facing optical window. The PHILLS will image in 10 nm bands over the wavelength range 400 to 1000 nm, and is designed to provide a signal-to-noise greater than 200 to 1 when viewing the relatively dark coastal ocean, coral, or on-shore vegetation. These images and ground truth will be used to develop and verify algorithms for water optical properties, chlorophyll, CDOM, bathymetry, bottom type, coral reef status, and to classify on-shore vegetation. The second phase of the program will install the University of Hawai'i MAHI short wave infrared hyperspectral imager in the WORF. This paper introduces the HICO program, and discusses the PHILLS and its implementation for HICO
The Harrington Discovery Institute and Alzheimer’s Disease Drug Development (2022)

Until recently, only five medicines have been approved for treatment of patients with Alzheimer’s disease (AD). Unfortunately, these agents offer just mild and temporary symptomatic improvement, without slowing progression of the disease itself. The Harrington Discovery Institute of University Hospitals Health System in Cleveland addresses this problem through a unique model that advances a diversified portfolio of new medicines for both treatment and prevention of AD. The institute identifies academic scientists in the USA, UK, and Canada who have made exceptionally innovative basic science discoveries related to AD and provides them with both financial support and critical programmatic direction. This latter contribution entails guidance and oversight from eminent drug developers whose collective expertise would normally only be available within a large pharmaceutical company. This enables academic scientists to bridge the “valley of death” between their scientific discoveries and development of medicines. As a result, HDI is bringing new medicines with novel mechanisms of action into the clinic for Alzheimer’s disease.
Local inflammation influences oestrogen metabolism in prostatic tissue (2011)

• The present work provides experimental evidence that local inflammation enhances oestrogen synthesis and directs oestrogen metabolism to generate catechol oestrogens within prostatic tissues. • This may contribute, at least partly, to enhanced prostatic cell proliferation.
[Surgical treatment of rotator cuff rupture. Prognostic factors]. (1992)

A retrospective study of 67 total ruptures of the rotator cuff operated on was carried on, with an average follow-up of 25 months. The lesions were characterised by their size (19 tears of less than 2 cm, 30 between 2 and 4 cm, 18 over 4 cm) and location (27 tears of the supraspinatus, 15 tears of the supraspinatus extending to the front (coraco-humeral, long biceps, subscapular), 20 supra and infra-spinatus, 5 "massive" tears). The tendon of the long biceps was pathological in half of the cases. Fourteen patients presented with a subacromial osteoarthritis. All patients benefited from a decompression and repair of the rupture. Whereas the subjective results indicate 92 per cent satisfied patients, from the objective point of view the average score with Constant's rating was 62.5 pts with 53 per cent favorable results. Evaluation of force was a particular subject of attention: the results obtained with three charts were compared; the conclusion was in favour of an objective measurement using a dynamometer but with a weighting according to age and sex. The characteristics of the tear (location especially), the state of the long biceps, the presence of a subacromial osteoarthritis and the pre-operative mobility affected statistically and significantly the final result. The authors reserve reconstructive surgery for tears without osteoarthritis, isolated lesions of the supraspinatus having the best prognosis. The existence of a subacromial osteoarthritis, always a sign of a massive tear, in elderly patients should lead one to choose a procedure a minima under arthroscopy.