gebhart/patrepeval huggingface dataset:
Embedded Sensors for Biomimetic Robotics via Shape Deposition Manufacturing (2006)

One of the greatest successes of biologically-inspired design has been the development of mechanically robust robots. One promising biomimetic fabrication technique is shape deposition manufacturing (SDM), which alternates material deposition and machining to produce robot structures with compliant joints and embedded actuation elements. In this paper, we add to the tools available to robot designers by describing the development of a range of sensing modalities. These include Hall-effect sensors for joint angle sensing, embedded strain gauges for 3 axis force measurements, optical reflectance sensors for tactile sensing, and piezoelectric polymers for contact detection. We demonstrate these sensors in the context of a simple robotic grasper using the biomimetic SDM process to simplify fabrication and produce robust sensing mechanisms
ChemInform Abstract: STEREOSELECTIVE PETERSON ALKOXYCARBONYLMETHYLENATION REACTION OF SUBSTITUTED CYCLOHEXANONES (1985)

Abstract Aus den Oxoverbindungen (I) erhält man mit den Anionen‐(II) die Kondensationsprodukte (III) in hohen Ausbeuten.
A VM 'Engine' that makes a difference: technical perspective (2010)

No abstract available.
Polarization-Based 43 Gb/s RZ-DQPSK Receiver Design Employing a Single Delay-Line Interferometer (2007)

We demonstrate a non-coherent receiver design requiring only a single delay-line interferometer. Demodulation of 43-Gb/s RZ-DQPSK is experimentally demonstrated with no penalty when compared to a traditional DQPSK receiver using two interferometers. Receiver alignment tolerances are quantified via simulation.
Emerging viral infections in transplant recipients (2005)

Transplant patients are uniquely predisposed to emerging infections. Lessons learned from West Nile virus and severe acute respiratory syndrome in transplantation should be applicable to future outbreaks of other emerging infectious diseases.
Sub-femtosecond Envelope Stability of Fiber Comb Lasers Locked to a CW Reference (2014)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text R. Wilcox, K. Hartinger, and R. Holzwarth, "Sub-femtosecond Envelope Stability of Fiber Comb Lasers Locked to a CW Reference," in CLEO: 2014, OSA Technical Digest (online) (Optica Publishing Group, 2014), paper SW3E.6. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Parallel interference cancellation (PIC) improvements for CDMA multiuser receivers using partial cancellation of MAI estimates (2002)

We study the improvement technique for multistage parallel interference cancellation (PIC) DS-CDMA multiuser receivers, which cancel only a fraction of the estimated multiple access interference (MAI) at each receiver stage. This technique takes into account the fact that the MAI estimate, especially in the earlier stages, contains substantial error, and a relatively conservative strategy of using the estimate may lead to better system performance (i.e., lower average bit error rate). We start with simulating the BER performance as a function of the fraction of cancellation, which shows that the fraction can make a significant difference and a "best" fraction can be far less than one. Then the PIC with partial cancellation and the standard PIC are compared under various near-far effects, channel SNR, and number of users. The simulations indicate how the partial cancellation technique can provide significant improvement over the standard PIC.
Activation of the carbon-hydrogen bonds of benzene by reaction with [bis(dicyclohexylphosphino)ethane]platinum(0), generated by the thermolysis of cis-[bis(dicyclohexylphosphino)ethane]hydridoneopentylplatinum(II) (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTActivation of the carbon-hydrogen bonds of benzene by reaction with [bis(dicyclohexylphosphino)ethane]platinum(0), generated by the thermolysis of cis-[bis(dicyclohexylphosphino)ethane]hydridoneopentylplatinum(II)Marifaith. Hackett, James A. Ibers, and George M. WhitesidesCite this: J. Am. Chem. Soc. 1988, 110, 5, 1436–1448Publication Date (Print):March 1, 1988Publication History Published online1 May 2002Published inissue 1 March 1988https://pubs.acs.org/doi/10.1021/ja00213a015https://doi.org/10.1021/ja00213a015research-articleACS PublicationsRequest reuse permissionsArticle Views562Altmetric-Citations101LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Numerical study of spectral shaping in high energy Ho:YLF amplifiers (2016)

We present a new chromatic numerical approach to simulate the amplification of laser pulses in multipass laser amplifiers. This enables studies on spectral effects such as gain narrowing and spectral shaping with optical elements expressed by a transmission transfer function. We observe good agreement between our simulations and measurements with a Ho:YLF regenerative amplifier (RA). To demonstrate the capabilities of our simulation model, we numerically integrate an intra-cavity etalon in this laser and find optimum etalon parameters that enhance the peak power of the output pulses up to 65%.
Catalyst Deactivation in Adiabatic Prereforming: Experimental Methods and Models for Prediction of Performance (1996)

Adiabatic prereforming has become an established process step in the production of syngas. The main deactivation phenomena for the prereforming catalyst are sulphur poisoning and carbon formation. Carbon formation proceeds either as carbon whiskers at high temperature or as gum at low temperature. Trouble free operation is ensured by selecting operating conditions and catalyst type. Experimental methods are used to characterize the deactivation phenomena. Prereforming catalysts have been investigated by use of Temperature Programmed Reaction (TPR) showing the presence of different carbon morphologies. Application of the pseudo-adiabatic reactor principle has ensured reliable adiabatic bench-scale tests providing data for industrial design. Methods based on intrinsic activity measurement have been developed to reveal the impact of the deactivation phenomena. Sulphur adsorption isotherms and mathematical models describing the complex interaction between pore diffusion, poisoning rate and reaction kinetics have been established and are used for design and performance prediction.
Novel blue light-emitting polymers for PLED (2004)

We have been researching blue-emitting polymers and developed some novel polymers with blue fluorescence, which are not fluorene copolymers. Our previous works showed the dependence of EL efficiency on molecular weight of poly(p-phenylene vinylene) derivatives. We concluded that polymers must be synthesized by the method which gave larger molecular weight in order to achieve higher performance. Firstly, we modified the synthetic method of polyarylenes and confirm that Mw of ca.1,000 to over 1,000,000 is obtainable depending on the condition. Polymers having moderately large Mw showed good solubility in solvents and film-forming properties. PLEDs using these polymers had longer lifetime as well as higher EL efficiency. Secondly, we understood the importance of charge balance between electrons and holes, by using polyfluorene derivatives as model polymers. We measured electron, hole and total currents by electron-only, hole-only and usual bipolar devices respectively. We found out that the hole mobility could be changed from 10<sup>-7</sup>cm<sup>2</sup>/Vs to 10<sup>-3</sup>cm<sup>2</sup>/Vs depending on the content of hole transporting units. In addition, electron injection from a cathode seemed to be assisted by trapped holes. We utilized these results in order to design our blue polymers. Finally, we obtained a new blue-emitting polymer, which showed longer device lifetime among non-fluorene polymers.
Tailoring Advanced Nanoscale Materials Through Synthesis of Composite Aerogel Architectures (2000)

Introducing a desired solid guest to an about-to-gel silica sol prevents complete encapsulation of the guest particles by the silica, such that the composite retains the bulk and surface properties of each component on the nanoscale. The transport- and density-dependent properties of the composite aerogel can be tuned by varying the volume fraction of the second solid, thereby increasing the design flexibility of these nanoscale materials for optical, chemical, thermal, magnetic, and electronic applications. The chemical and physical properties of the composite material can be further engineered at multiple points during sol–gel processing by modifying the host solid, the guest solid, the composite gel, or the composite aerogel.
Enhancing the adsorption capacity of copper in aqueous solution by citric acid modified sugarcane bagasse (2017)

This study investigated the chemical modification method by citric acid and its enhancement effect on the adsorption capacity of sugarcane bagasse (SB) for copper removal from aqueous solution. Characterization studies were performed by using Fourier transform infra red (FTIR), which showed the introduction of carboxylic group in the structure the modified sugarcane bagasse (MSB). Batch study revealed the influence of pH, time, initial concentration of metal ion on adsorption capacity. The data showed an extremely good fit to Langmuir isotherm model from which the maximum adsorption capacity estimated reached 28.17 mg/g at optimum pH 5.5. Fixed bed column study using the adsorbent MSB confirmed that the breakthrough curves of the adsorption processes were de- pendent on bed height, initial concentration and flow rate. Linear regression analysis of the data demonstrated that Yoon-Nelson kinetic models were appropriate to explain the breakthrough curves. Nghiên cứu đã thực hiện biến tính hóa học vật liệu bã mía bằng acid citric và đánh giá khả năng hấp phụ ion Cu(II) trong nước của bã mía (SB) trước và sau biến tính axit citric. Khảo sát cấu trúc vật liệu thông qua phổ hồng ngoại FTIR cho thấy các nhóm chức carboxylic có khả năng hấp phụ kim loại xuất hiện trong vật liệu biến tính. Thí nghiệm mẻ đánh giá sự ảnh hưởng của pH, thời gian và nồng độ của vật liệu tự nhiên và biến tính đến khả năng hấp phụ ion Cu(II). Kết quả của thí nghiệm mẻ phù hợp với mô hình Langmuir với khả năng hấp phụ cực đại đạt 28,17 mg/g tại nồng độ pH tối ưu là 5,5. Kết quả thí nghiệm trên mô hình cột cho thấy đường cong thoát của quá trình hấp phụ của vật liệu biến tính và chưa biến tính phụ thuộc và chiều cao lớp vật liệu, nồng độ ion Cu(II) ban đầu và vận tốc dòng chảy qua cột. Các dữ liệu thu nhận được từ thực nghiệm phù hợp với mô hình động học Yoon-Nelson.
3D shape measurement of objects with uncooperative surface by projection of aperiodic thermal patterns in simulation and experiment (2020)

3D shape measurement systems based on diffuse reflection of projected structured light are widely used. Unfortunately, this measurement principle does not work for uncooperative materials, i.e., materials with optical properties such as being glossy, transparent, absorbent, or translucent. Recently, it was shown that 3D reconstruction of an uncooperative object can be performed by a two-step process. In the first step, the object absorbs a projected thermal pattern. In the second step, after energy conversion, the object surface reemits a diffused thermal pattern according to Planck’s law. To achieve high 3D result qualities in short measurement times, projection parameters such as irradiance pattern and irradiation period must be optimized depending on optical and thermal material properties, e.g., complex spectral refractive index, thermal conductivity, specific heat capacity, or emissivity. Therefore, we have developed a simulation tool to describe the entire measurement process beginning with the projection unit, followed by the interaction of the irradiation with the measurement object, reemission of thermal radiation and recording unit, and finally the 3D reconstruction. In this contribution, we present our simulation tool, verify it with measurement results, and apply it to investigations of the influence of projection and material parameters on the 3D result quality.
Multiple Dice Working as One: CAD Flows and Routing Architectures for Silicon Interposer FPGAs (2015)

Large field-programmable gate array (FPGA) systems with multiple dice connected by a silicon interposer are now commercially available. However, many questions remain concerning their key architecture parameters and efficiency, as the signal count between dice is reduced and the delay between the dice is increased compared with a monolithic FPGA. We modify the versatile place and route (VPR) to target interposer-based FPGAs and investigate placement and routing changes and incorporating partitioning into the flow to improve results. Our best computer-aided design (CAD) flow reduces the routing demand for interposer FPGAs with realistic connectivity between dice by 47% and improves the circuit speed by 13% on average. Architecture modifications to add routing flexibility when crossing the interposer are very beneficial and improve routability by a further 11%. With these CAD and architecture enhancements, we find that if an interposer supplies (between dice) 20% of the routing capacity that the normal (within-die) FPGA routing channels supply, there is only a modest impact on circuit routability. Smaller interposer-routing capacities do impact routability; however, minimum channel width increases by 70% when an interposer supplies only 10% of the within-die routing. The interposer also impacts delay, increasing circuit delay by 11% on average for a 1-ns interposer signal delay and a two-die system.
Towards using hybrid word and fragment units for vocabulary independent LVCSR systems (2009)

This paper presents the advantages of augmenting a word-based system with sub-word units as a step towards building open vocabulary speech recognition systems. We show that a hybrid system which combines words and data-driven, variable length sub word units has a better phone accuracy than word only systems. In addition the hybrid system is better in detecting Out-Of-Vocabulary (OOV) terms and representing them phonetically. Results are presented on the RT-04 broadcast news and MIT Lecture data sets. An FSM-based approach to recover OOV words from the hybrid lattices is also presented. At an OOV rate of 2.5% on RT-04 we observed a 8% relative improvement in phone error rate (PER), 7.3% relative improvement in oracle PER and 7% relative improvement in WER after recovering the OOV terms. A significant reduction of 33% relative in PER is seen in the OOV regions.
N‐methylation of Nα‐acylated, fully Cα‐methylated, linear, folded peptides: Synthetic and conformational aspects (2006)

Peptides characterized by single or multiple N-methylated, C(alpha)-trisubstituted (e.g., protein) amino acids are of great interest in medicinal chemistry. Several naturally occurring peptides, remarkably stable to enzymatic attacks, are based on N-methylated residues. The classical conditions (CH(3)I/Ag(2)O in DMF, 24 h, room temperature) for N-methylation of the peptide function are useful tools for distinguishing solvent exposed from intramolecularly H-bonded -CO-NH- groups in peptides. In this work we have extended this reaction to N(alpha)-acylated, linear peptides based exclusively on helicogenic C(alpha)-tetrasubstituted alpha-amino acids, e.g., Aib (alpha-aminoisobutyric acid) or (alphaMe)Nva (C(alpha)-methyl norvaline) residues. Under the experimental conditions used, only amide monomethylation (on the N-terminal, acylated, residue) takes place. Methylation of internal peptide groups linking two C(alpha)-tetrasubstituted residues was not observed. Our FT-IR absorption, NMR, and X-ray diffraction investigations support the view that the beta-turn and 3(10)-helical conformations preferred by the original peptides are not dramatically perturbed in the derivatives monomethylated at position 1. In particular, the tertiary amide bonds are trans. Conversely, the packing modes in the crystals are strongly influenced by the reduction of the number of H-bonding donors. The MeXxx-Xxx peptide bond is readily disrupted under mild acidic conditions.
Cerebromeningitis in Immunosuppressed Recipients of Renal Allografts (1982)

The experience with cerebromeningitis in recipients of 769 renal allografts occurring over a 20-year period has been reviewed. Eighteen patients developed this complication; an incidence of 2.7%. Clinical manifestations were often subtle, although fever occurred almost universally. Primary risk factors included diabetes mellitus, use of high dose steroids both as maintenance immunosuppression and as treatment for acute rejection, and coincident infections or complications. The responsible organisms were fungi; the overall mortality rate 44%. By recognizing individual patient types who are at potential high risk for this complication, earlier diagnosis and more prompt and aggressive therapy has diminished the mortality dramatically in the last several years.
BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking CLU + CAF expression with HSF1 signaling (2021)

Abstract Cancer-associated fibroblasts (CAFs) give rise to desmoplastic stroma, which supports tumor progression and metastasis, and comprises up to 90% of the tumor mass in pancreatic cancer. Recent work by us and others has shown that CAFs are transcriptionally rewired by adjacent cancer cells to form heterogeneous subtypes. Whether this rewiring is differentially affected by different driver mutations in cancer cells is largely unknown. Here we address this question by dissecting and comparing the stromal landscape of BRCA -mutated and BRCA Wild-type (WT) pancreatic ductal adenocarcinoma (PDAC). We comprehensively analyze PDAC samples from a cohort of 42 patients by laser-capture microdissection, RNA-sequencing and multiplexed immunofluorescence, revealing different CAF subtype compositions in germline BRCA -mutated vs. BRCA -WT tumors. In particular, we detect an increase in a subset of Clusterin (CLU)-positive CAFs in BRCA -mutated tumors. We further unravel a network of stress responses upregulated in BRCA -mutated tumors. Using cancer organoids and cell co-cultures, we show that the transcriptional shift of pancreatic stellate cells into CLU + CAFs is mediated through activation of heat-shock factor 1 (HSF1), the transcriptional regulator of Clu . Our findings unravel a new dimension of stromal heterogeneity, influenced by germline mutations in cancer cells, with direct translational implications for clinical research. Significance BRCA1 / 2 mutations initiate some of the deadliest cancers, yet the fibroblastic microenvironment of BRCA -mutated cancers remains uncharted. Our work addresses a major unsolved question – to what extent is the tumor microenvironment determined by cancer mutations? We find that BRCA mutations in the cancer cells affect the composition of CAFs in PDAC. These findings have direct implications for diagnosis and for efforts to exploit CAFs for therapy.
The selenite-capped polyoxo-4-aurate(iii), [AuIII4O4(SeIVO3)4]4− (2012)

The discrete heteropolyaurate [Au(III)(4)O(4)(Se(IV)O(3))(4)](4-) (Au(4)Se(4)) represents only the second member of this class ever reported, and was synthesized via one-pot room temperature condensation in aqueous medium. was structurally characterized in the solid state and in solution by single-crystal XRD, TGA, FT-IR, (77)Se NMR, mass spectrometry and electrochemistry.
Fast three-dimensional laser scanning scheme using acousto-optic deflectors (2005)

A scheme for fast 3-D laser scanning using acousto-optic deflectors is proposed and demonstrated. By employing counterpropagating acoustic waves that are both chirped and offset in their frequencies, we show that it is possible to simultaneously scan both axially and laterally with frame rates on the order of tens of kilohertz. This scheme was specifically designed for application with multiphoton imaging, particularly of neurons, where it will enable the concurrent monitoring of physiological signals at multiple locations within a microscopic 3-D volume (350 x 350 x 200 microm). When used for this purpose, we demonstrate how this scheme would also inherently compensate for spatial dispersion when ultrafast laser pulses are used in acousto-optic multiphoton microscopy.
Redefining the Histone Deacetylase Inhibitor Pharmacophore: High Potency with No Zinc Cofactor Interaction (2021)

A novel series of histone deacetylase (HDAC) inhibitors lacking a zinc-binding moiety has been developed and described herein. HDAC isozyme profiling and kinetic studies indicate that these inhibitors display a selectivity preference for HDACs 1, 2, 3, 10, and 11 via a rapid equilibrium mechanism, and crystal structures with HDAC2 confirm that these inhibitors do not interact with the catalytic zinc. The compounds are nonmutagenic and devoid of electrophilic and mutagenic structural elements and exhibit off-target profiles that are promising for further optimization. The efficacy of this new class in biochemical and cell-based assays is comparable to the marketed HDAC inhibitors belinostat and vorinostat. These results demonstrate that the long-standing pharmacophore model of HDAC inhibitors requiring a metal binding motif should be revised and offers a distinct class of HDAC inhibitors.
Regioselective Synthesis of Demethoxyisoacronycine Involving Nucleophilic Addition to Benzyne (2003)

Demethoxyisoacronycine (12) has been prepared in seven steps using the nucleophilic addition of aniline derivative (4) to benzyne (5) as a key step.
Aggregation of red cells and linear velocity gradients: influence on the correlation-based method for quantitative IVUS blood flow at 20 MHz (2003)

Recent computer simulations suggest that the presence of aggregates of red blood cells (RBCs), at random angles and lengths, does not affect the measurements of transverse blood flow using a correlation-based method and an IVUS array catheter. Blood velocity gradients were also shown not to influence the correlation-based method for blood velocity estimation. The objective of this study is to quantify the influence of aggregates of RBCs and blood velocity gradients on the correlation-based method during in vitro experiments. For this purpose, measurements were performed on normal and diseased human blood. The decorrelation pattern of a circular ultrasound transducer as a function of transverse blood flow was studied using a Couette system. Agreements were found between the auto-convolution of the acoustical beam and the RF decorrelation patterns.
Mediastinal lymphadenopathy in patients with or without previous malignancy: EUS-FNA-based differential cytodiagnosis in 153 patients (2000)

In patients without previous cancer malignant ML originates from the lung >80%. In those with previous malignancy recurrence of extrathoracic sites is the major cause. Benign lesions and treatable second cancers occur in a significant frequency, emphasizing the need for tissue diagnosis. EUS-FNA is a safe and minimally invasive alternative for cytodiagnosis in the mediastinum.