gebhart/patrepeval huggingface dataset:
Bayesian Deep Convolutional Networks with Many Channels are Gaussian\n Processes (2018)

There is a previously identified equivalence between wide fully connected\nneural networks (FCNs) and Gaussian processes (GPs). This equivalence enables,\nfor instance, test set predictions that would have resulted from a fully\nBayesian, infinitely wide trained FCN to be computed without ever instantiating\nthe FCN, but by instead evaluating the corresponding GP. In this work, we\nderive an analogous equivalence for multi-layer convolutional neural networks\n(CNNs) both with and without pooling layers, and achieve state of the art\nresults on CIFAR10 for GPs without trainable kernels. We also introduce a Monte\nCarlo method to estimate the GP corresponding to a given neural network\narchitecture, even in cases where the analytic form has too many terms to be\ncomputationally feasible.\n Surprisingly, in the absence of pooling layers, the GPs corresponding to CNNs\nwith and without weight sharing are identical. As a consequence, translation\nequivariance, beneficial in finite channel CNNs trained with stochastic\ngradient descent (SGD), is guaranteed to play no role in the Bayesian treatment\nof the infinite channel limit - a qualitative difference between the two\nregimes that is not present in the FCN case. We confirm experimentally, that\nwhile in some scenarios the performance of SGD-trained finite CNNs approaches\nthat of the corresponding GPs as the channel count increases, with careful\ntuning SGD-trained CNNs can significantly outperform their corresponding GPs,\nsuggesting advantages from SGD training compared to fully Bayesian parameter\nestimation.\n
Coded-excitation Raman spectroscopy for ethanol chemometrics of tissue (2006)

Raman spectroscopy of bulk tissue is challenging due to sample auto-fluorescence and weak Raman cross-sections of most molecules. We investigate the use of coded-excitation Raman spectroscopy coupled with an iterative algorithm for Raman signal estimation.
Integration of sub-wavelength nanofluidics on suspended photonic crystal sensors (2010)

In this paper, we introduce a novel sensor scheme which merges nano-photonics and nano-fluidics on a single platform through the use of free-standing photonic crystals (PhCs). PhCs offer great freedom to manipulate the spatial extent and the spectral characteristics of the electromagnetic fields. Also, nanoholes in PhCs provide a natural platform to transport solutions. By harnessing these nano-scale openings, we theoretically and experimentally demonstrate that both fluidics and light can be manipulated at sub-wavelength scales. In this scheme, the free standing PhCs are sealed in a chamber such that only the nano-scale hole arrays enable the flow between the top and the bottom channels. The nanohole arrays are used as sensing structures as well as nanofluidic channels. Compared to the conventional fluidic channels, we can actively steer the convective flow through the nanohole openings for effective delivery of the analytes to the sensor surface. This scheme also helps to overcome the surface tension of highly viscous solution and guarantees that the sensor can be totally immersed in solution. We apply this method to detect refractive index changes in aqueous solutions. Bulk measurements indicate that active delivery of the convective flow results in better performance. The sensitivity of the sensor reaches 510 nm/RIU for resonance located around 850 nm with a line-width of &#126;10 nm in solution. Experimental results are matched very well with numerical simulations. We also show that cross-polarization measurements can be employed to further improve the detection limit by increasing the signal-to-noise ratio.
Synthesis of poly(ethylene oxide)-b-poly(N-isopropylacrylamide) by RAFT polymerization and their utilization as structure directing agents for the preparation of functionalized mesoporous silica (2011)

International audience
Synergistic drug combination effectively blocks Ebola virus infection (2016)

Although a group of FDA-approved drugs were previously identified with activity against Ebola virus (EBOV), most of them are not clinically useful because their human blood concentrations are not high enough to inhibit EBOV infection. We screened 795 unique three-drug combinations in an EBOV entry assay. Two sets of three-drug combinations, toremifene-mefloquine-posaconazole and toremifene-clarithromycin-posaconazole, were identified that effectively blocked EBOV entry and were further validated for inhibition of live EBOV infection. The individual drug concentrations in the combinations were reduced to clinically relevant levels. We identified mechanisms of action of these drugs: functional inhibitions of Niemann-Pick C1, acid sphingomyelinase, and lysosomal calcium release. Our findings identify the drug combinations with potential to treat EBOV infection.
Any progress in informed consenting for cancer treatment? Results from a cross sectional analysis at a comprehensive cancer center (2021)

To ensure that informed consent is based on solid understanding, informed consenting must be patient-centered and consider the individual expectations, needs and abilities of cancer patients. Further studies are required to develop tailored informed consent strategies.
Nutrient regulation of mTORC1 at a glance (2019)

The mechanistic target of rapamycin (mTOR) signaling pathway coordinates environmental and intracellular cues to control eukaryotic cell growth. As a pivot point between anabolic and catabolic processes, mTOR complex 1 (mTORC1) signaling has established roles in regulating metabolism, translation and autophagy. Hyperactivity of the mTOR pathway is associated with numerous human diseases, including diabetes, cancer and epilepsy. Pharmacological inhibition of the mTOR pathway can extend lifespan in a variety of model organisms. Given its broad control of essential cellular processes and clear relevance to human health, there is extensive interest in elucidating how upstream inputs regulate mTORC1 activation. In this Cell Science at a Glance article and accompanying poster, we summarize our understanding of how extracellular and intracellular signals feed into the mTOR pathway, how the lysosome acts as an mTOR signaling hub, and how downstream signaling controls autophagy and lysosome biogenesis.
Switchable Assembly of Ultra Narrow CdS Nanowires and Nanorods (2006)

We report on a simple route for the production of uniform and ultra narrow wurtzite CdS nanowires and nanorods. The nanorods are medium friendly (can exist in organic and aqueous phase) thus making them flexibly suitable for various applications. The centimeter range switchable ordering of the nanowires/rods into 3D microstrings by application of low magnitude DC electric field simply via two graphite electrodes is demonstrated. More sophisticated electrodes can be used for the same system to achieve more complex and fine patterns that can find potential use in nanoelectronics. The aligned microstrings (also wires/rods) show strong polarization dependence along their long axes. The polarized emission with respect to the unique c-axis makes the system suitable for orientation sensitive devices.
Vector field processing on triangle meshes (2015)

While scalar fields on surfaces have been staples of geometry processing, the use of tangent vector fields has steadily grown in geometry processing over the last two decades: they are crucial to encoding directions and sizing on surfaces as commonly required in tasks such as texture synthesis, non-photorealistic rendering, digital grooming, and meshing. There are, however, a variety of discrete representations of tangent vector fields on triangle meshes, and each approach offers different tradeoffs among simplicity, efficiency, and accuracy depending on the targeted application.
Catalytic ethylene polymerization : novel reators for kinetics in gas, slurry and solution processes (2004)

7 Introduction General slurry and gas phase polymerizations 9 State of the art 9 This work 10 Experimental 10 Setup 10 Control 13 Chemicals and monomer purification 15 Procedures 16 Reaction rate measurement 17 Examples and Discussion 19 Slurry homo-polymerizations 19 Gas phase homo-polymerizations 21 Gas phase co-polymerizations 21 Conclusions 24 Acknowledgement 24 Notation 25 Greek letters 25 Subscript 25 Superscript 26 Abbreviations 26 Literature 26
An integer programming approach to routing in daisy networks (2006)

Abstract We are concerned with routing problems arising in special kinds of SDH networks, called daisy networks. Beside the capacity constraints, some disjoint edge‐sets of the network, called arcs, are also prescribed. Our goal is to find a routing of the demands satisfying the capacities with the additional constraint that whenever a path (with value 1) enters an arc then it uses capacity 1 on all edges of that arc. We consider two types of arc‐systems and give algorithms and computational results of integer programming formulations. © 2006 Wiley Periodicals, Inc. NETWORKS, Vol. 47(2), 116–121 2006
Passive Flexible-Substrate Blast Sensor Array (2012)

We have developed a design for a wearable passive blast sensor array to detect the peak shock experienced by personnel exposed to high energy events. The sensor is fabricated on a flexible substrate using a MEMS process. The design includes an array of sensors, each element of which is triggered at a different pressure level and which records the peak pressure by means of a permanently deformed diaphragm. The elements can be integrated with a flexible electrophoretic display or can be interrogated externally with an electronic reader. A key application is in predicting the exent of traumatic brain injury for military peronnel exposed to explosions in a battlefield environment. Peak blast information can assist in prioritizing and determining the appropriate battlefield treatment. The flexible substrate allows integration into personal armor or clothing and the passive nature of the sensor ensures a very long shelf life and reduces cost and maintenance. Details of the sensor designs and process flows for their fabrication are described. Prototype sensors have been fabricated and the fabrication characterized. Also included are simulation results for the preforamnce of the arrays. Finally, preliminary pressure blast test data for indivdual sensor elements are presented.
Mission Studies Bibliography (1994)

140 Mission Studies Bibliography Robert J. Schreiter, Reconciliation - Mission and Ministry in a Changing Social Order, Orbis Books, Maryknoll, N.Y., 1992 (The Boston Theological Institute Series No. 3), 84 pp. Robert J. Schreiter, C.PP.S., author of the missiological classic ,Constructing Local Theologies' (Orbis, 1985), professor of Historical and Doctrinal Studies at Catholic Theological Union, Chicago, presents in this most recent little book the expanded version of his lectures during the 1991 Orlando E. Costas Consultation on Missions at Boston Theological Institute. While he intends to focus,,on societies experiencing a shift in their social order and the need for reconciliation
Absence of oncogenic mutations of RAS family genes in soft tissue sarcomas of 100 Japanese patients. (2010)

Activating mutations of the RAS gene family are uncommon events in soft tissue sarcomas in Japanese patients.
Aligning Chips Face-to-Face for Dense Capacitive and Optical Communication (2010)

We report a new method that precisely self-aligns face-to-face semiconductor chips or wafers to enable communication between the chips using electromagnetic waves. Our alignment mechanism takes advantage of miniaturized versions of two of nature's idealized shapes: an inverse pyramidal shape defined by a self-terminating wet-etch process in silicon and micro-spheres with radii accurate to submicron accuracy. This approach allows chips to be packaged using passive alignment that is self locating and reaches nearly one micron level of chip misalignment tolerance. Packages for applications to capacitive and optical connections are presented. Additionally, we describe a physical architecture for a multi-chip array packages with ¿bridge¿ and ¿island¿ chips where the function of the bridge is to transfer electromagnetic signals between island chips using either capacitive or optical proximity communication. The bridge chip can provide a predetermined amount of compliance to help maintain alignment and thereby accommodate topology variants in first level package or in chip thickness when required. Experimental packages providing precise alignment between 1-D arrays and 2-D arrays of chips are presented. We show that our precision alignment mechanism enables high fidelity 10 Gb/s optical-proximity-communication with reflecting mirrors micro-machined into Silicon and co-integrated to low loss silicon-on-insulator waveguides for chip-to-chip communication. The alignment mechanism was also applied to a demonstration of chip-to-chip capacitive proximity communication in a linear array of six chips. Alignment measurements on a 4 × 4 array of chips are reported.
Simulation of room acoustics via block-based physical modelingwith the functional transformation method (2006)

An application of block-based physical modeling for the simulation of room acoustics with the functional transformation method (FTM) is presented in this paper. In doing so, an analytic solution of the two-dimensional wave equation for rectangular regions achieved with the FTM is employed as a simple block element of the entire model. Due to a recently introduced approach to block-based modeling, it is possible to apply arbitrary boundary conditions for this block, including the connection to other blocks and the simulation of openings. By the connection of several block elements, it is possible to construct and simulate complex regions with complex boundaries. In result a new wave field simulation technique is achieved, that avoids the disadvantages of the FTM, the restriction to simple regions, while preserving its advantages like dispersion-free simulation and exact source and receiver positioning
Perturbation-Based Pre-compensation for Intra-channel Fiber Nonlinearities (2014)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Y. Gao, A. S. Karar, J. C. Cartledge, S. S. -. Yam, M. O'Sullivan, C. Laperle, A. Borowiec, and K. Roberts, "Perturbation-Based Pre-compensation for Intra-channel Fiber Nonlinearities," in Advanced Photonics for Communications, OSA Technical Digest (online) (Optica Publishing Group, 2014), paper SW2C.4. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Abstract 239: p53 Protects Cardiac Stem Cells From the Toxic Effects of Chemotherapy and Controls their Fate (2013)

Doxorubicin (DOXO) causes dilated cardiomyopathy and heart failure. We have documented previously that DOXO-mediated cardiotoxicity is dictated by functional alterations of cardiac stem cells (CSCs). DOXO-induced myopathy was coupled with a reduction in CSC number due to increased death, inhibition of proliferation, and senescence. We raised the possibility that survival and growth of CSCs following DOXO treatment may be enhanced by modulating the intracellular level of p53, which plays a critical role in the determination of stem cell fate. For this purpose, transgenic mice carrying an additional p53 allele (Sp53) were studied. With respect to wild-type mice (WT), CSCs isolated from Sp53 mice (Sp53-CSCs) showed increased apoptosis with accumulation of the pro-apoptotic p53 targets BAX, PUMA and Pidd. Conversely, the expression of p21Cip1, a cell cycle inhibitor and inducer of cell senescence, was lower in Sp53-CSCs than WT cells. Upon DOXO treatment, Sp53-CSCs exhibited accelerated onset of apoptosis. However, viable Sp53-CSCs showed enhanced formation of DNA damage response foci, indicative of a very efficient DNA repair mechanism. Following removal of DOXO, Sp53-CSCs re-entered the cell cycle and divided, while WT cells continued to die by apoptosis or became senescent. The response of WT-CSCs to DOXO involved the pro-apoptotic Bcl2 family member Noxa and the senescence-associated protein p16INK4a. In contrast, exposure of Sp53-CSCs to DOXO provoked pulses of p53 expression, which favored sustained upregulation of Mdm2. Mdm2 antagonized the inhibitory effect of p53 on cell growth and prevented apoptosis. Ultimately, Sp53-CSCs showed accumulation of PCNA, which is required for DNA repair and synthesis. Importantly, IGF-1 release was higher in Sp53-CSCs, promoting their replication through an autocrine-paracrine mechanism. Collectively, our data demonstrate that changes in the pattern of p53 expression have beneficial effects on CSCs by amplifying the DNA repair response, facilitating the clearance of cells with non-repairable DNA damage, and enabling the proliferation of cells in which DNA lesions are effectively removed. Thus, targeting p53 expression in CSCs may protect the heart from the toxic effects of chemotherapy.
Rapidly Processed Stool Swabs Approximate Stool Microbiota Profiles (2019)

Studies of the intestinal microbiome commonly utilize stool samples to measure the microbial composition in the distal gut. However, collection of stool can be difficult from some subjects under certain experimental conditions. Sampling of fecal material using sterile swabs can streamline sample collection, handling, and processing. In this study, we validate the use of swabs of fecal matter to approximate measurements of microbiota in stool using 16S rRNA gene Illumina amplicon sequencing and evaluate the effects of shipping time at ambient temperatures on accuracy. The results indicate that swab samples reliably replicate the stool microbiota bacterial composition, alpha diversity, and beta diversity when swabs are processed quickly (≤2 days) but that sample quality quickly degrades after this period and is accompanied by increased abundances of <i>Enterobacteriaceae</i> Fresh swabs appear to be a viable alternative to stool sampling when standard collection methods are challenging, but extended exposure to ambient temperatures prior to processing threatens sample integrity.<b>IMPORTANCE</b> Collection of fecal swab samples simplifies handling, processing, and archiving compared to collection of stool. This study confirms that fecal swabs reliably replicate the bacterial composition and diversity of stool samples, provided that the swabs are processed shortly after collection. These findings support the use of fecal swabs, when shipping and handling are done properly, to streamline measurements of intestinal microbiota.
Randomised clinical trial of two treatment regimens of natural surfactant preparations in neonatal respiratory distress syndrome. (1995)

The Curosurf treatment regimen resulted in a more rapid improvement in oxygenation than Survanta and reduced ventilatory requirements up to 24 hours after start of treatment. This was associated with a trend towards reduced incidence of serious pulmonary and non-pulmonary complications.
Ballistics Modeling for Non-Axisymmetric Hypervelocity Smart Bullets (2014)

Abstract : A method for calculating the trajectories of guided, non-axisymmetric, hypervelocity projectiles is developed. The method is based on the equations of motion for a rigid body with an internal skid weight and roll wheel, combined with a tabulated set of ballistic coefficients used to specify the aerodynamic forces and moments on the body. The ballistic coefficients can in principle come from experiments or computational fluid dynamics (CFD) calculations. CFD calculations are carried out for a standard bullet (0.308 168 grain Sierra International) in order to characterize the accuracy given various mesh sizes. The ballistics model is applied to a standard rifle shot in order to demonstrate the epicyclic pitch and yaw behavior. It is then applied to a smart bullet that utilizes a preliminary autopilot algorithm.
Characterising the UHF factory radio channel (1987)

Portable UHF factory multipath measurement apparatus is being used to measure multipath delay profiles and narrowband fading at five large manufacturing sites in the mid-western US. Preliminary data indicate that typical RMS delay spreads range from 100 to 250 ns and that average CW path loss varies as distance to the power 2-2. This work is the first report of extensive multipath measurements in factory environments.
Transition Metal Catalyzed Cycloadditions:  An Intramolecular [4 + 4] Cycloaddition Strategy for the Efficient Synthesis of Dicyclopenta[a,d]cyclooctene 5−8−5 Ring Systems (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTTransition Metal Catalyzed Cycloadditions: An Intramolecular [4 + 4] Cycloaddition Strategy for the Efficient Synthesis of Dicyclopenta[a,d]cyclooctene 5−8−5 Ring SystemsPaul A. Wender, John M. Nuss, David B. Smith, Angel Suárez-Sobrino, Jan Vågberg, Debra Decosta, and Jon BordnerView Author Information Department of Chemistry, Stanford University, Stanford, California 94305, and Pfizer Central Research, Groton, Connecticut 06340 Cite this: J. Org. Chem. 1997, 62, 15, 4908–4909Publication Date (Web):July 25, 1997Publication History Received12 May 1997Published online25 July 1997Published inissue 1 July 1997https://doi.org/10.1021/jo970841xCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views1091Altmetric-Citations100LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (104 KB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Alcohols,Cyclization,Hydrocarbons,Molecular structure,Redox reactions Get e-Alerts
Conference of Microelectronic Research 1990 (1990)

https://repository.rit.edu/meec_archive/1003/thumbnail.jpg
Procedimiento y catalizadores para la obtención de epóxidos y derivados hidroxilados de ácidos y ésteres de ácidos grasos (1999)

Referencia OEPM: P9601086.-- Fecha de solicitud: 16/05/1996.-- Titulares: Universidad Politécnica de Valencia (UPV), Consejo Superior de Investigaciones Científicas (CSIC).