gebhart/patrepeval huggingface dataset:
99mTc-EC-DG: A novel tracer for tumor imaging (2005)

2021 Background: The aims were to study 1) mechanisms of cellular uptake and 2) biodistribution of 99mTc-ethylenedicysteine-glucosamine (EC-DG) in animals and humans. Methods: To evaluate if 99mTc-EC-DG is involved in cell nuclei activity, in vitro thymidine incorporation and cell cycle assays of EC-DG were conducted using lung and breast cancer cells. Biodistribution of 99mTc-EC-DG in lung-tumor bearing mice (0.5–4 hrs, 1 μCi/mouse, iv) was used to estimate radiation absorbed dose. Autoradiograms of 99mTc-EC-DG and 18F-FDG were compared in nude mice bearing uterine sarcoma. Rabbits inoculated with VX-2 cells were imaged with 99mTc-EC-DG and 99mTc-EC. For therapeutic assessment studies, scintigraphic imaging studies with 99mTc-EC-DG in mammary tumor-bearing rats were conducted at various days after treatment with paclitaxel and cisplatin. The imaging findings were correlated immunohistochemical assays (mRNA expression, apoptosis and cell cycle changes in tumor) and flow cytometry analysis was performed. Biodistribution of 99mTc-EC-DG was performed in patients with non-small cell lung cancer. Radiation dosimetry was assessed using the MIRD method. Results: In vitro cellular uptake assays indicated that cell nuclei activity could be assessed by 99mTc-EC-DG. Scintigraphy and autoradiograms in animal models demonstrated the tumor could be clearly visualized by 99mTc-EC-DG. The efficacy of paclitaxel and cisplatin treatment in rodent models could be assessed using tumor/muscle ratios. Immunohistochemical staining indicated reduced expression of bFGF and increased apoptosis and cell cycle changes after paclitaxel and cisplatin treatment. The critical organ in human was the kidneys with an average radiation absorbed dose over all seven patients of 1.23E-02 mGy/MBq. The average total body absorbed dose was 2.35–03 mGy/MBq (2.61E-01 cGy/1110 MBq). Conclusions: 99mTc-EC-DG is involved in cell nuclei activity and could assess of therapeutic tumor response in animals. The novel 99mTc-EC-DG is safe and promising as a molecular imaging agent. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Cell Point LLC
A Disturbance in Sensory Processing on the Affected Side of the Body Increases Limb Pain in Complex Regional Pain Syndrome (2013)

These preliminary findings suggest that a central disturbance in sensory processing and pain modulation, which extends beyond the affected limb to the ipsilateral forehead, contributes to symptoms in a subgroup of patients with CRPS.
An Autonomous Environmental Logging Microsystem (ELM) for Harsh Environments (2021)

This paper describes the design, implementation, and evaluation of an environmental logging microsystem (ELM) for operation at elevated pressure and in corrosive environments, at temperatures up to 125°C. The ELM units are intended to be deployed in large quantities, allowed to collect data, and then retrieved, interrogated, and re-charged. Powered by a rechargeable battery embedded within the system, each ELM incorporates pressure and temperature sensors, control electronics, optical communication elements, and power management and battery re-charging circuits. The pressure sensor is a customized capacitive transducer chip on a sapphire substrate; details are provided in a companion paper. The electronic components and battery used in ELM are selected on the basis of functionality and form factor; packaged components are selected for ease of assembly and for added protection against the environment. The pressure sensor, electronics and battery are assembled on a flexible circuit board, folded into a stack with dimensions 7.2 mm × 6.6 mm × 6.5 mm, and encapsulated in a steel tube filled with optically transparent silicone caulk. This encapsulation provides mechanical protection against shock and abrasion, as well as chemical protection against high salinity environments, while allowing the ambient pressure and temperature to be transferred to the sensing elements. Results are reported from high-temperature and high-pressure tests reaching 125°C and 7,250 psi in brine and other corrosive environments in laboratory conditions. Field tests that were conducted in a brine well to a maximum depth of 1,235 m are also described. The recorded data were post-processed to interpret the environmental pressure and temperature.
An algorithm for triangulating multiple 3D polygons (2013)

Abstract We present an algorithm for obtaining a triangulation of multiple, non‐planar 3D polygons. The output minimizes additive weights, such as the total triangle areas or the total dihedral angles between adjacent triangles. Our algorithm generalizes a classical method for optimally triangulating a single polygon. The key novelty is a mechanism for avoiding non‐manifold outputs for two and more input polygons without compromising optimality. For better performance on real‐world data, we also propose an approximate solution by feeding the algorithm with a reduced set of triangles. In particular, we demonstrate experimentally that the triangles in the Delaunay tetrahedralization of the polygon vertices offer a reasonable trade off between performance and optimality.
Single or multiple arterial bypass graft surgery vs. percutaneous coronary intervention in patients with three-vessel or left main coronary artery disease (2021)

Registered on clinicaltrial.gov. SYNTAXES: NCT03417050 (https://clinicaltrials.gov/ct2/show/NCT03417050); SYNTAX: NCT00114972 (https://www.clinicaltrials.gov/ct2/show/NCT00114972).
Application of a membrane condenser system for ammonia recovery from humid waste gaseous streams at a minimum energy consumption (2022)

Abstract Among the various technologies for the removal and recovery of chemicals from gaseous streams, the membrane condenser (MCo) is proposed and analyzed in this work. In particular, the case of MCo used for the recovery of ammonia at minimum energy consumption is reported. For reaching this aim, three different MCo configurations have been proposed and compared. They differ in the way cooling is achieved: in configuration 1, the feed is cooled via cooling water before entering the membrane module; in configuration 2, a cold sweeping gas cools the feed stream directly inside the membrane module; in configuration 3, the feed is first partially cooled via an external medium and then a sweeping gas is used for the final cooling of the stream. The achieved results indicate configuration 2, among the three different proposed schemes, the one allowing to minimize energy consumption while permitting good water and chemicals recovery.
Correlated alternative side chain conformations in the RNA-recognition motif of heterogeneous nuclear ribonucleoprotein A1 (2002)

The RNA-recognition motif (RRM) is a common and evolutionarily conserved RNA-binding module. Crystallographic and solution structural studies have shown that RRMs adopt a compact alpha/beta structure, in which four antiparallel beta-strands form the major RNA-binding surface. Conserved aromatic residues in the RRM are located on the surface of the beta-sheet and are important for RNA binding. To further our understanding of the structural basis of RRM-nucleic acid interaction, we carried out a high resolution analysis of UP1, the N-terminal, two-RRM domain of heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1), whose structure was previously solved at 1.75-1.9 A resolution. The two RRMs of hnRNP A1 are closely related but have distinct functions in regulating alternative pre-mRNA splice site selection. Our present 1.1 A resolution crystal structure reveals that two conserved solvent-exposed phenylalanines in the first RRM have alternative side chain conformations. These conformations are spatially correlated, as the individual amino acids cannot adopt each of the observed conformations independently. These phenylalanines are critical for nucleic acid binding and the observed alternative side chain conformations may serve as a mechanism for regulating nucleic acid binding by RRM-containing proteins.
Architecture and applications of dynamic survivable resource pooling in battlefield networks (2004)

We present Dynamic Survivable Resource Pooling (DSRP) that provides survivable access to resources and services in battlefield networks. The servers accessed by mobile users (e.g., FCS backbone managers, TPKI, Bandwidth Brokers, Situation Awareness/Common Network Picture, SIP) are pooled together for higher availability and failover; the Name Servers (NSs) are responsible for maintaining server pools, load balancing, and server discovery. In the DSRP scheme, NSs are placed on a virtual backbone (VB): a highly distributed, scalable, and survivable network formed and maintained through one-hop beacons. By making locally scoped decisions, VB is capable of reorganizing both itself and pool registrations in response to mobility, failures, and partitioning. A proof-of-concept of the DSRP successfully demonstrated its survivability.
Dendrites and synapses (2014)

Neurons have intricate morphologies: the central part of the cell is the soma, which contains the genetic information and a large fraction of the molecular machinery. At the soma originate long wire-like extensions which come in two different flavors. First, the dendrites form a multitude of smaller or larger branches on which synapses are located. The synapses are the contact points where information from other neurons (i.e., “presynaptic” cells) arrives. Second, also originating at the soma, is the axon, which the neuron uses to send action potentials to its target neurons. Traditionally, the transition region between soma and axon is thought to be the crucial region where the decision is taken whether a spike is sent out or not.
Novel ophthalmological features in hereditary endotheliopathy with retinopathy, nephropathy and stroke syndrome (2005)

The ophthalmic features are reported of a member of an Australian pedigree with three affected individuals spanning two generations with a hereditary endotheliopathy syndrome resulting in retinopathy, leukoencephalopathy and nephropathy. The index case initially presented with asymptomatic retinopathy, cerebral microvascular disease, nephropathy and raised inflammatory markers. The clinical, neuro-radiological, biochemical and histopathological findings in this patient are consistent with a diagnosis of hereditary endotheliopathy, retinopathy, nephropathy and stroke (HERNS). Linkage analysis has identified a locus for HERNS on chromosome 3p21.1-p21.3. This locus is shared with two other diseases: hereditary vascular retinopathy (HVR) and cerebroretinal vasculopathy (CRV). Although peripheral retinal involvement is a feature of HVR, it has not previously been described in HERNS. This case represents a novel phenotype of HERNS, and serves to blur the distinction between the vasculopathies mapping to chromosome 3p21. Although previously thought to be distinct clinical entities, it is possible that HERNS, HVR and CRV simply represent different phenotypes of the same disease. This will only be clarified with the identification of the gene or genes. This case also raises the question of how best to manage rare forms of vascular retinopathy.
Isolation enhancment of two planar monopole antennas for MIMO wireless applications (2015)

This paper presents a planar slotted meander line structure to reduce the mutual coupling between two microstrip fed planar monopole patch antennas. The array provides a relative operating bandwidth of 98 % (1.37-4.00) GHz matched at a reflection coefficient S11 and S22 less than -10 dB with a total realized gain of 3.9, 4.66, and 4 dB at 1.85, 2.4, and 3.5 GHz respectively. The isolation level has been reduced to less than -20 dB for a wide frequency band of 85 % (1.46-3.64) GHz. The design represents a good candidate for modern wireless standards utilizing MIMO techniques including 3GPP LTE, WiMAX, WiFi, as well as systems utilizing ISM spectrum equipped with multiple antennas.
Figure S5 from Mechanism-Based Epigenetic Chemosensitization Therapy of Diffuse Large B-Cell Lymphoma (2023)

&lt;p&gt;Figure S5 - PDF file 224K, Toxicity studies in mice&lt;/p&gt;
[Dynamic local cerebral circulation study in patients with cerebral diseases--using 99mTc-HSA-D mainly compared with 99mTc-HSA]. (1989)

We have been using 99mTc-RBC and 99mTc-HSA for cerebral angiography and measurement of the local cerebral blood volume (LCBV) and cerebral/peripheral hematocrit ratio (alpha). 99mTc-HSA, however, has a problem of poor stability in the blood. We conducted basic and clinical studies on 99mTc-HSA-D, a ready-to-use preparation with good stability in the blood. We measured the regional cerebral circulation dynamics in patients with cerebral diseases in comparison with 99mTc-RBC and 99mTc-HSA. 99mTc-HSA-D and 99mTc-RBC showed more than a 90% retention ratio in the blood 60 min after administration, and good SPECT images were obtained using these two pharmaceuticals. On the contrary, 99mTc-HSA was unstable and its retention ratio was 60s% 60 min after administration. 99mTc-HSA does not provide good SPECT images due to free 99mTcO4- which seems to be liberated from 99mTc-HSA in the body, etc. There were no adverse reactions or abnormal laboratory findings caused by the 99mTc-HSA-D administration in any of the patients. Based on these results, it is surmised that 99mTc-HSA-D is clinically useful for measurement of the cerebral blood volume and cerebral/peripheral hematocrit ratio (alpha).
Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres (2014)

We previously reported the discovery of potent and selective morpholinone and piperidinone inhibitors of the MDM2-p53 interaction. These inhibitors have in common a carboxylic acid moiety that engages in an electrostatic interaction with MDM2-His96. Our continued search for potent and diverse inhibitors led to the discovery of novel replacements for these acids uncovering new interactions with the MDM2 protein. In particular, using pyridine or thiazole as isosteres of the carboxylic acid moiety resulted in very potent analogues. From these, AM-6761 (4) emerged as a potent inhibitor with remarkable biochemical (HTRF IC50 = 0.1 nM) and cellular potency (SJSA-1 EdU IC50 = 16 nM), as well as favorable pharmacokinetic properties. Compound 4 also shows excellent antitumor activity in the SJSA-1 osteosarcoma xenograft model with an ED50 of 11 mg/kg. Optimization efforts toward the discovery of these inhibitors as well as the new interactions observed with the MDM2 protein are described herein.
Filibuvir, a non-nucleoside NS5B polymerase inhibitor for the potential oral treatment of chronic HCV infection. (2010)

Filibuvir (PF-868554), being developed by Pfizer, is an orally administered, non-nucleoside inhibitor of the HCV NS5B RNA-dependent RNA polymerase for the potential treatment of chronic HCV infection. An estimated 180 million people worldwide are infected with HCV and at risk of developing chronic liver diseases that can lead to cirrhosis or hepatocellular carcinomas. HCV infection is the main cause of liver transplantation in industrialized nations. Filibuvir is a potent and specific inhibitor of the virally-encoded NS5B polymerase, and inhibited genotype 1 subgenomic HCV replication in the cell-based replicon system. Filibuvir demonstrated a good pharmacokinetic profile and oral bioavailability in preclinical animal studies, which is consistent with twice-daily dosing in humans. In phase I and a IIa clinical trial in treatment-naïve patients infected with genotype 1 HCV, filibuvir monotherapy or in combination with pegylated IFNα2a/ribavirin (the standard of care [SoC] for HCV infection) for up to 4 weeks significantly reduced HCV RNA levels compared with placebo or SoC alone. The incidence and severity of adverse events were similar to SoC and placebo. At the time of publication, phase I pharmacokinetic clinical trials were ongoing in healthy volunteers and a phase IIb clinical trial was assessing filibuvir in combination with SoC for up to 24 weeks in treatment-naïve patients infected with genotype 1 HCV. Results of this trial will help to characterize the potential of this drug class for the treatment of HCV infections.
Coordination of Distributed Energy Storage Under Spatial and Temporal Data Asymmetry (2017)

We consider the problem of controlling distributed storage in a network with renewable distributed generation to minimize operational cost while satisfying power quality constraints. We assume control is distributed between a global controller (GC) and local controllers (LCs) located at the nodes with storage units. Each LC has access to its most recent net load data and runs at every time step while the GC has delayed data due to smart meter infrastructure or communication network delay, hence runs less frequently. We describe three control schemes: 1) direct storage controller (DSC) in which the GC computes the storage control signals for an upcoming window and the LCs directly use these signals; 2) net load following controller (NLFC) in which the GC computes a net load profile for each node and each LC tries to track its set profile; and 3) nodal slack controller (NSC) in which the GC computes upper and lower bounds on the net load at each node and the LC optimizes the local control action constrained by these bounds. We use a radial network with real load data to compare the performance of these schemes based on arbitrage profit and maximum solar penetration relative to a perfect foresight controller. We find that NSC and NLFC increase the supported maximum solar penetration to 29% and 40%, respectively, as compared to 10% for DSC. Moreover, NSC is able to capture 90.7% of the available arbitrage profits which is significantly higher than that achievable with NLFC and DSC.
Effects of Alternative Side Chain Pairings and Reverse Turn Sequences on Antiparallel Sheet Structure in β-Peptide Hairpins (2004)

[structure: see text] We describe a series of beta-peptide hexamers that allow us to explore relationships between sequence and hairpin folding. Different reverse turn segments are compared at the central two positions, and the outer residues allow a variety of interstrand side chain-side chain pairings. NMR analysis in methanol demonstrates that several reverse turn and side chain pairing arrangements are compatible with antiparallel beta-peptide sheet structure; however, none of the beta-peptides folds in water.
Synthesis, spectroscopic characterization, dynamics, and phosphine trapping of Cp(CO)Fe[.eta.3-CH(R)C6H5] complexes (R = H, OCH3) (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis, spectroscopic characterization, dynamics, and phosphine trapping of Cp(CO)Fe[.eta.3-CH(R)C6H5] complexes (R = H, OCH3)Maurice Brookhart, Robert C. Buck, and Earl Danielson IIICite this: J. Am. Chem. Soc. 1989, 111, 2, 567–574Publication Date (Print):January 1, 1989Publication History Published online1 May 2002Published inissue 1 January 1989https://pubs.acs.org/doi/10.1021/ja00184a026https://doi.org/10.1021/ja00184a026research-articleACS PublicationsRequest reuse permissionsArticle Views116Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
A Short C-terminal Domain of Yku70p Is Essential for Telomere Maintenance (2000)

The Yku heterodimer from Saccharomyces cerevisiae, comprising Yku70p and Yku80p, is involved in the maintenance of a normal telomeric DNA end structure and is an essential component of nonhomologous end joining (NHEJ). To investigate the role of the Yku70p subunit in these two different pathways, we generated C-terminal deletions of the Yku70 protein and examined their ability to complement the phenotypes of a yku70(-) strain. Deleting only the 30 C-terminal amino acids of Yku70p abolishes Yku DNA binding activity and causes a yku(-) phenotype; telomeres are shortened, and NHEJ is impaired. Using conditions in which at least as much mutant protein as full-length protein is normally detectable in cell extracts, deleting only 25 C-terminal amino acids of Yku70p results in no measurable effect on DNA binding of the Yku protein, and the cells are fully proficient for NHEJ. Nevertheless, these cells display considerably shortened telomeres, and significant amounts of single-stranded overhangs of the telomeric guanosine-rich strands are observed. Co-overexpression of this protein with Yku80p could rescue some but not all of the telomere-related phenotypes. Therefore, the C-terminal domain in Yku70p defines at least one domain that is especially involved in telomere maintenance but not in NHEJ.
1456: Effects of ICM-L-136, a Novel Sodium Channel Blocker, on Detrusor Overactivity (DO) in a Rat Model of Bladder Outlet Obstruction (BOO) (2006)

You have accessJournal of UrologyModerated Poster, Wednesday, May 24, 2006, 8:00 - 10:00 am1 Apr 20061456: Effects of ICM-L-136, a Novel Sodium Channel Blocker, on Detrusor Overactivity (DO) in a Rat Model of Bladder Outlet Obstruction (BOO) Hwancheol Son, Adam P. Klausner, Sang-Kuk Yang, Seema Sharma, Timothy Batts, Manoj K. Patel, Milton L. Brown, Jeremy B. Tuttle, and William D. Steers Hwancheol SonHwancheol Son More articles by this author , Adam P. KlausnerAdam P. Klausner More articles by this author , Sang-Kuk YangSang-Kuk Yang More articles by this author , Seema SharmaSeema Sharma More articles by this author , Timothy BattsTimothy Batts More articles by this author , Manoj K. PatelManoj K. Patel More articles by this author , Milton L. BrownMilton L. Brown More articles by this author , Jeremy B. TuttleJeremy B. Tuttle More articles by this author , and William D. SteersWilliam D. Steers More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)33660-7AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "1456: Effects of ICM-L-136, a Novel Sodium Channel Blocker, on Detrusor Overactivity (DO) in a Rat Model of Bladder Outlet Obstruction (BOO)." The Journal of Urology, 175(4S), p. 470 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 175 Issue 4S April 2006 Page: 470 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetrics Author Information Hwancheol Son More articles by this author Adam P. Klausner More articles by this author Sang-Kuk Yang More articles by this author Seema Sharma More articles by this author Timothy Batts More articles by this author Manoj K. Patel More articles by this author Milton L. Brown More articles by this author Jeremy B. Tuttle More articles by this author William D. Steers More articles by this author Expand All Advertisement PDF downloadLoading ...
High performance composite polymer electrolytes for lithium-ion polymer cells composed of a graphite negative electrode and LiFePO4 positive electrode (2015)

A lithium-ion polymer cell assembled with a composite polymer electrolyte containing optimized core–shell SiO<sub>2</sub> particles exhibited good cycling performance.