gebhart/patrepeval huggingface dataset:
ChemInform Abstract: Stereoselective Conjugate Addition of Lactams to Nitroalkenes and Formal Total Synthesis of Indolizidine 167B. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
On-chip thermo-optic tuning of suspended microresonators (2017)

Suspended optical microresonators are promising devices for on-chip photonic applications such as radio-frequency oscillators, optical frequency combs, and sensors. Scaling up these devices demands the capability to tune the optical resonances in an integrated manner. Here, we design and experimentally demonstrate integrated on-chip thermo-optic tuning of suspended microresonators by utilizing suspended wire bridges and microheaters. We demonstrate the ability to tune the resonance of a suspended microresonator in silicon nitride platform by 9.7 GHz using 5.3 mW of heater power. The loaded optical quality factor (Q<sub>L</sub> ~92,000) stays constant throughout the detuning. We demonstrate the efficacy of our approach by completely turning on and off the optical coupling between two evanescently coupled suspended microresonators.
The promise of bioimpedance for volume management in American dialysis patients: An unfulfilled opportunity (2019)

Evidence from both observational and randomized controlled studies indicates that the use of bioimpedance in the care of chronic hemodialysis patients is associated with improved outcomes, in particular better volume and blood pressure control. Bioimpedance as a means to assess fluid status in dialysis patients has been approved by numerous regulatory agencies and is being used in dozens of countries around the globe. The most notable exception to the worldwide acceptance of this technique is the US where no BIA device has been approved by the US Food and Drug Administration for use in dialysis patients. The reasons for this unfortunate situation are manifold and mostly flawed. They include the view that bioimpedance is inaccurate and not sufficiently validated, that clinical judgment is good enough to assess fluid status, that interdialytic changes in weight are satisfactory indicators of fluid status (overload, depletion, and euvolemia), costs, and regulatory and marketing barriers. Easing the path to approval and modifying the dialysis payment structure are necessary to bring dialysis care closer to the levels that will optimize patient outcomes.
Effects of Micronutrients on Serum Antioxidant Status of Glaucoma Patients: A Randomized, Placebo-controlled, Double-masked Pilot Study (2014)

Aims: Glaucoma is a chronic eye disease, which is associated with progressive optic neurodegeneration and concomitant visual field defects. Besides an elevated intraocular pressure, recent studies have suggested that other risk factors such as oxidative stress may play an important role in the pathogenesis of glaucoma. The goal of this study was to examine the effects of oral micronutrients on the antioxidant status in glaucoma patients. Study Design: randomized, placebo-controlled, double-masked pilot study. Place and Duration of Study: Ophthalmological Clinic Oculus Parter-Bucharest,
Power Perfomance Tests on a Different Wind Turbine Rotor Blade Design (2010)

Most blades available for commercial grade wind turbines incorporate a straight, span-wise profile and airfoil-shaped cross-sections. These blades are found to be very efficient at low and medium wind speeds compared with the potential energy that can be extracted. This paper explores the possibility of increasing the efficiency of the blades by modifying the blade design to incorporate a swept edge. The design intends to maintain efficiency at low to medium wind speeds by selecting the appropriate orientation and size of the airfoil cross-sections based on an oncoming wind speed and given constant rotation rate. The torque generated from a blade with straight edge geometry is compared with that generated from a blade with a swept edge as predicted by CFD simulations. To validate the simulations, the experimental curve of the NTK500/41 turbine using LM19.1 blades will be reproduced using the same computational conditions. In addition, structural deformations, stress distributions, and structural vibration modes are compared between these two different turbine blade surfaces.
Stones: Editorial Comment (1995)

Division of Urology, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.
Copper-based 2D Conductive Metal Organic Framework Thin Films for Ultrasensitive Detection of Perfluoroalkyls in Drinking Water (2022)

Perfluoroalkyls (PFAS) continue to emerge as a global health threat making their effective detection and capture extremely important. Though metal organic frameworks (MOF) have stood out as a promising class of porous materials for sensing PFAS, detection limits remain insufficient and fundamental understanding of detection mechanisms warrant further investigation. Here we show the use of a 2D conductive MOF film based on copper hexahydroxy triphenylene (Cu-HHTP) to fabricate a chemiresistive sensing device for detecting PFAS in drinking water. We further show ultrasensitive detection using electrochemical impedance spectroscopy. Owing to excellent electrostatic attractions and electrochemical interactions between the copper-based MOF and PFAS, the MOF-based sensor reported herein exhibits unprecedented affinity and sensitivity towards perfluorinated acids at concentrations as low as of 0.002 ng/L.
AEG-1 Promoter–Mediated Imaging of Prostate Cancer (2014)

We describe a new imaging method for detecting prostate cancer, whether localized or disseminated and metastatic to soft tissues and bone. The method relies on the use of imaging reporter genes under the control of the promoter of AEG-1 (MTDH), which is selectively active only in malignant cells. Through a systemic, nanoparticle-based delivery of the imaging construct, lesions can be identified through bioluminescence imaging and single-photon emission computed tomography in the PC3-ML murine model of prostate cancer at high sensitivity. This approach is applicable for the detection of prostate cancer metastases, including bone lesions for which there is no current reliable agent for noninvasive clinical imaging. Furthermore, the approach compares favorably with accepted and emerging clinical standards, including PET with [(18)F]fluorodeoxyglucose and [(18)F]sodium fluoride. Our results offer a preclinical proof of concept that rationalizes clinical evaluation in patients with advanced prostate cancer.
Position Statement: SIGIR Workshop on Implicit Measures of User Interests and Preferences (1995)

As the economic importance of the web has grown, so has the importance of prominent placement in web search engines. As a result, search engine designers must worry not only about how to provide the best results for their users, but also how to prevent unscrupulous web site creators from manipulating their ranking. Implicit measures of user preferences, such as click data, may offer a way out of this engine vs. spammer arms race. At the same time, click data has dangers of its own – for example, the potential for positive feedback loops. There are also dangers in imputing positive relevance assessments to user behaviors that may actually reflect surprise or puzzlement. My interest in harnessing implicit user behavior to improve the search experience dates back to an experimental IR system I created as part of my graduate research [1], in which user clicks resulted in changes not only to the current search results, but also to the underlying search features. While managing Information Access research at Apple, I was involved in some early work on collaborative filtering [2]. Now, as technical lead of Advanced Development for
Synthesis of group 4 complexes that contain the tridentate diamido ligands [(ArNCH2CH2)2O]2− (Ar = C6H3-Me2-2,6 or C6H3Pri2-2,6) (1998)

Complexes of Zr and Hf of the type [(2,6-R2C6H3NCH2CH2)2O]ZrMe2 (R = Me or Pri) can be activated by [PhNMe2H][B(C6F5)4] or [Ph3C][B(C6F5)4] in chlorobenzene or bromobenzene to yield catalysts for the polymerization of hex-1-ene, but analogous titanium catalysts are relatively poorly behaved.
Scalar Additive Operators in the Languages of Europe (2011)

Scalar additive operators, such as Engl. even , Fr. même , Germ, sogar , Sp. aun , and so forth, vary crosslinguistically in terms of their distributional behavior, in particular with respect to semantic and pragmatic properties of the sentential environment (scale-reversing vs. scale-preserving, negative vs. nonnegative). This article proposes a semantic framework for the crosslinguistic analysis of scalar additive operators and a typology based on that framework. Five major types of operators are distinguished and the distribution of these types in forty European languages is surveyed. The synchronic patterns found in the languages of the sample are interpreted in the light of historical developments in the domain of investigation, and implications for the division of labor between lexical meaning and sentential context are discussed.
ChemInform Abstract: Synthesis of Hydroxamic Acids by Activation of Carboxylic Acids with N,N′‐Carbonyldiimidazole: Exploring the Efficiency of the Method. (2010)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Effect of different regimens of chemotherapy on stem-cell marker expression. (2007)

B32 Background:  Nanog is a critical factor underlying pluripotency in embryonic stem cells. The genetic program induced by Nanog is maintained by BMI1 and other epigenetic regulators that belong to the family of polycomb group proteins (PcG). The expression of stem cells markers has been associated with poor therapeutic outcome for patients with various types of cancer. However, the effects of chemotherapy on stem cells have not been fully elucidated.  Methods:  A transplantable mesenchymal chondrosarcoma (MCS) xenograft model was used to evaluate the effects of chemotherapy on tumor growth. Drug combinations were selected based on the cell signaling activation profile detected in MCS and included the alkylating agent Ifosfamide, VEGF inhibitors (Avastin and Sorafenib), an inhibitor of telomerase activity (Irinotecan), a regulator of microtubule assembly (Docetaxel) and a proteosome inhibitor (Velcade). After treatment, paraffin embedded MCS tissue samples were evaluated for changes in morphological features, cell signaling activation and stem cell markers (Nanog, Oct4, BMI1) expression. MCS cells lines were used for in vitro functional studies.  Results:  Morphological patterns in MSC xenograft model were similar to the primary human MCS and included two distinct tumor components: small round mesenchymal cells and cells differentiated towards cartilage. A high level of proliferation (Ki67), activations of VEGF signaling pathway (VEGF, VFGFR1, VEGFR2, EphA4 and phospho-VEGFF), RAS ERK signaling (phospho-ERK) and activation of anti apoptotic pathway (phospho-Akt) were found in both primary human MCS and in the MSC xenograft model. The MCS cells lines similarly demonstrated activation of VEGF and PI3K-Akt signaling, and were characterized by PI3K dependant type of cell migration in Boyden Chamber assays. Nanog and BMI1 expressions both were increased in metastases as compared to primary MCS; they were also detectable in MCS xenograft model and in MSC cell lines by PCR and immunostaining.  All chemotherapeutical regimens resulted in inhibition of MCS growth; however, different regimens induced specific post treatment morphological changes in xenografts. The combination of Ifosfamide and Avastin induced necrosis and inhibited growth of differentiated cartilaginous cells. Avastin treatment also inhibited Nanog and BMI1 expression. Treatment with Irinotecan, Docetaxel or Velcade resulted in formation of highly cellular tumors without necrosis. MCS cells which survived chemotherapy were characterized by increased expression of Nanog and BMI1. Docetaxel and Velcade induced Nanog, Oct4, BMI1, EZH2 expression in the MCS cell lines.  Conclusions:  Targeted chemotherapy altered cancer stem cell marker expression. Some chemotherapeutic agents resulted in a gain of stem cell marker expression. Therapeutic combination of such agents with compounds targeting developmental signals (e.i. Notch, HH) therefore might improve the outcome of sarcoma treatment.
Observational multi-centre, prospective study to characterize novel pathogen-and host-related factors in hospitalized patients with lower respiratory tract infections and/or sepsis - the “TAILORED-Treatment” study (2018)

NCT02025699 . Registration Date: January, 1, 2014.
<title>Monitoring micro floor vibrations with distributed fiber optic sensors</title> (1999)

In certain applications, such as microelectronic manufacturing, monitoring and controlling small floor vibrations can be essential. This paper describes how an array of distributed fiber optic sensor can be used to monitor micro floor vibrations as part of an adaptive control strategy. The performance target is to limit vibrations in 'the 10 Hz frequency range to less than 10 microinches peak to peak. The distributed fiber optic sensor are of an interferometric design that uses a single mode to multi mode to single mode configuration. The fibers are laid in an orthogonal grid so as to localize vibration hot spots. Data comparing the performance of the vibration sensing array with that of conventional point piezoelectric accelerometers, as well as sensing and control strategies will be presented.
Identification and filtering of uncharacteristic noise in the CMS hadron calorimeter (2010)

Commissioning studies of the CMS hadron calorimeter have identified sporadic uncharacteristic noise and a small number of malfunctioning calorimeter channels. Algorithms have been developed to identify and address these problems in the data. The methods have been tested on cosmic ray muon data, calorimeter noise data, and single beam data collected with CMS in 2008. The noise rejection algorithms can be applied to LHC collision data at the trigger level or in the offline analysis. The application of the algorithms at the trigger level is shown to remove 90% of noise events with fake missing transverse energy above 100 GeV, which is sufficient for the CMS physics trigger operation.
Replacement of oxide glass with metallic glass for Ag screen printing metallization on Si emitter (2011)

Cu–Zr-based metallic glass (MG) has been applied as a binding agent of Ag paste for front contact formation in Si solar cell by screen printing process. Use of electroconductive MG binder significantly improves the quality of the contact by the formation of highly dense 10–50 nm size Ag crystallites and the noncorrugation of the emitter surface with a very shallow Ag crystallite penetration depth of 10–30 nm. Nanoscale Ag crystallites form on the emitter surface by local Si–Cu–Ag eutectic melting, leading to the formation of pyramidal pits on the Si emitter surface, followed by precipitation of Ag crystallites during cooling.
Homochiral fluoroorganic compounds. Part 17. 2-(p-Tolylsulphinylmethyl)-3-fluorotetrahydro-pyrans and -furans through intramolecular oxymercuriation (1991)

The four unsaturated α-fluoro alcohols, 3-fluoro-1-[(p-tolyl)sulphinyl]hept-5-en-2-ols and 3-fluoro-6-methyl-1-[(p-tolyl)sulphinyl]hept-5-en-2-ols 3 having the (2S,3S,Rs) or (2S,3R,Rs) absolute configuration, gave the corresponding 6-methyl-or 6,6-dimethyl-substituted 5-chloromercurio-3-fluoro-2-[(p-tolyl)sulphinyl]tetrahydropyrans 5 and 6 and the 5-[1′-(chloromercurio)ethyl]-3-fluoro-2-[(p-tolyl)sulphinyl]tetrahydrofurans 4 by ‘endo’ or ‘exo’ cyclooxymercuriation promoted by mercury(II) trifluoroacetate. All the synthesized compounds have been isolated in optically pure form and their structure, absolute configuration, and preferred conformation have been established by 1H, 13C and 19F NMR studies. Elaboration of the chloromercurio and sulphinylmethyl substituents on a couple of diastereoisomeric tetrahydropyrans 6 allowed us to obtain the corresponding 3-fluoro-2-hydroxymethyltetrahydropyrans 11.
Bendamustine rituximab (BR) versus ibrutinib (Ibr) as primary therapy for Waldenström macroglobulinemia (WM): An international collaborative study. (2022)

7566 Background: Parenteral limited-duration BR chemoimmunotherapy and continuous orally administered Ibr, a Bruton tyrosine kinase inhibitor, dominate the treatment landscape of WM, a rare B cell lymphoma. No trials have assessed the comparative effectiveness of these 2 vastly different approaches. We conducted a multiinstitutional, international, collaborative study to compare BR and single-agent Ibr in patients (pts) with treatment naïve (TN) WM. Methods: Data from 347 pts with active TN WM, seen between 2011 and 2021 in the US and Europe, were analyzed. The pts on rituximab maintenance were excluded. The modified IWWM-6 criteria (based on IgM alone) were used for response assessment. All time-to-event analyses were performed from the frontline therapy initiation, using the Kaplan-Meier method. Results: The median age of the pts treated with BR (n=208) and Ibr (n=139) was 66 (range 40-86) years (y) and 69 (39-97) y, respectively, (p=0.005). With a median follow up of 4.2 y (95% CI 3.8-4.5), the 4-y progression free survival (PFS) was 73% in each group, p=0.6, and 4-y overall survival (OS) was 94% (95% CI 91-98) in the BR group versus ( v) 82% (95% CI 75-90) in the Ibr group, p=0.01. In a bivariate analysis adjusting for age and the treatment type, only age emerged as a predictor for OS (HR 7.2, p=0.0001). Therefore, a 1:1 age-matched analysis of 246 pts who received Ibr (n=123) or BR (n=123) was performed. Pts with a known MYD88 WT status who had received Ibr and their age matched controls on BR were excluded. The international prognostic scoring system (IPSS) WM was comparable between the 2 groups (Table). A higher proportion of pts on BR attained very good partial or deeper response (≥VGPR) as the best response in comparison to the pts on Ibr (Table). The 4-y PFS for the BR and Ibr groups was similar [72% (95% CI 63-82) v 78% (95% CI 70-87), p=0.14] and 4-y OS was 95% (95% CI 91-99) with BR v 86% (95% CI 80-93) with Ibr (p=0.3). Premature discontinuation, during active treatment, due to adverse effects (AEs) or lack of response was noted in 13% and 33% of pts on BR and Ibr, respectively. A detailed assessment of the AEs will be presented at the meeting. Conclusions: Both BR and Ibr lead to comparable outcomes in pts with TN WM, although deeper responses are attained with BR. These findings require confirmation in prospective studies. For pts who harbor MYD 88 L265P mutation, selection between the 2 approaches should be dictated by their potential toxicities, pt comorbidities, pt/clinician preference (parenteral fixed-duration v continuous oral) and access to therapies. [Table: see text]
Hybrid silicon integration technology (2010)

As the component count rises in photonic systems, photonic integration becomes increasingly attractive from a cost, power consumption, and footprint perspective due ability to reduce the on-chip to off-chip interfaces and simplify packaging. Although photonic integration has been investigated in many forms over the last decade, the incompatibility of passive and active devices in standard integration platforms has limited their use in commercial systems. In this talk, we review the hybrid silicon integration platform; an integration platform that provides state of the art active and passive devices integrated on silicon substrate with simple passive fiber packaging.
Supplemental Table 3 from mWTX-330, an IL-12 INDUKINE Molecule, Activates and Reshapes Tumor-Infiltrating CD8<sup><b>+</b></sup> T and NK Cells to Generate Antitumor Immunity (2023)

&lt;p&gt;Differential Gene Expression Analysis of EMT-6 Tumor Infiltrating CD8+ T cells&lt;/p&gt;
Treatment of SU-8 surfaces using atmospheric pressure dielectric barrier discharge plasma (2018)

Dielectric barrier discharge (DBD) plasma was used to change the wettability of a SU-8 photoresist, reducing the contact angle and improving the surface smoothness. As most polymers, SU-8 has hydrophobic surfaces which prevents the adhesion of biological samples when used to fabricate biochemical sensors. Here, DBD Plasma treatment was conducted over the SU-8 surface, reducing the contact angle from 78° to 12°. The advantage of this treatment is that the SU-8 surface maintains the hydrophilic surface behavior over 24 h time period. DBD plasma modified the SU-8 surface wettability under low temperature variation and does not cause great irregularities on the surface. The highest value of root mean square surface roughness after 10 min exposure was 2.9 ± 0.3 nm.
Relation of Alcohol, Physical Activity, Dietary Fat and Smoking to Serum HDL and Total Cholesterol in Young Finnish Men (1985)

The study was based on 471 men, aged 19 to 20 years, who started their compulsory military service in three military bases in Southwest, Southeast and Northern Finland in February 1982. The data were gathered by means of self-administered questionnaires. A fasting venous blood specimen was taken to determine serum HDL and total cholesterol, gamma-glutamyltransferase and thiocyanate. In this cross-sectional study a few variables based on the self-administered questionnaire explained 8% and 7% of the variation in serum HDL and total cholesterol, respectively. Our results show that easily measurable behavioural factors do contribute to serum HDL and total cholesterol levels in young men. In our study the impact of alcohol consumption on serum HCL cholesterol was greater than in most previous studies. Our findings give additional support to the hypothesis that even a very modest amount of regular physical exercise has the effect of increasing the serum HDL cholesterol level.
Predicting non-coding RNA genes in Escherichia coli with boosted genetic programming (2005)

Several methods exist for predicting non-coding RNA (ncRNA) genes in Escherichia coli (E.coli). In addition to about sixty known ncRNA genes excluding tRNAs and rRNAs, various methods have predicted more than thousand ncRNA genes, but only 95 of these candidates were confirmed by more than one study. Here, we introduce a new method that uses automatic discovery of sequence patterns to predict ncRNA genes. The method predicts 135 novel candidates. In addition, the method predicts 152 genes that overlap with predictions in the literature. We test sixteen predictions experimentally, and show that twelve of these are actual ncRNA transcripts. Six of the twelve verified candidates were novel predictions. The relatively high confirmation rate indicates that many of the untested novel predictions are also ncRNAs, and we therefore speculate that E.coli contains more ncRNA genes than previously estimated.
ANALYTICAL APPROACH TO THE DEVELOPMENT OF A BRIDGE MANAGEMENT SYSTEM (1991)

A study to determine feasibility and define the general structure of a bridge management system (BMS) for the Texas State Department of Highways and Public Transportation's 47,000 highway bridges is described. The decentralized nature of bridge management in the SDHPT's district offices suggests that a BMS for Texas should have primary applicability at the district level. Specific recommendations for the characteristics and scope of a BMS are presented. Development of the recommended BMS is planned to culminate with implementation in September, 1992, followed by a period of evaluation and refinement.