gebhart/patrepeval huggingface dataset:
Search for supersymmetry in final states with jets, missing transverse momentum and one isolated lepton ins=7  TeVpp collisions using1  fb−1of ATLAS data (2012)

We present an update of a search for supersymmetry in final states containing jets, missing transverse momentum, and one isolated electron or muon, using $1.04\text{ }\text{ }{\mathrm{fb}}^{\ensuremath{-}1}$ of proton-proton collision data at $\sqrt{s}=7\text{ }\text{ }\mathrm{TeV}$ recorded by the ATLAS experiment at the LHC in the first half of 2011. The analysis is carried out in four distinct signal regions with either three or four jets and variations on the (missing) transverse momentum cuts, resulting in optimized limits for various supersymmetry models. No excess above the standard model background expectation is observed. Limits are set on the visible cross section of new physics within the kinematic requirements of the search. The results are interpreted as limits on the parameters of the minimal supergravity framework, limits on cross sections of simplified models with specific squark and gluino decay modes, and limits on parameters of a model with bilinear $R$-parity violation.
High Level of Fasting Plasma Proenkephalin-A Predicts Deterioration of Kidney Function and Incidence of CKD (2016)

High levels of proenkephalin-A (pro-ENK) have been associated with decreased eGFR in an acute setting. Here, we examined whether pro-ENK levels predict CKD and decline of renal function in a prospective cohort of 2568 participants without CKD (eGFR>60 ml/min per 1.73 m<sup>2</sup>) at baseline. During a mean follow-up of 16.6 years, 31.7% of participants developed CKD. Participants with baseline pro-ENK levels in the highest tertile had significantly greater yearly mean decline of eGFR (P<sub>trend</sub><0.001) and rise of cystatin C (P<sub>trend</sub>=0.01) and creatinine (P<sub>trend</sub><0.001) levels. Furthermore, compared with participants in the lowest tertile, participants in the highest tertile of baseline pro-ENK concentration had increased CKD incidence (odds ratio, 1.51; 95% confidence interval, 1.18 to 1.94) when adjusted for multiple factors. Adding pro-ENK to a model of conventional risk factors in net reclassification improvement analysis resulted in reclassification of 14.14% of participants. Genome-wide association analysis in 4150 participants of the same cohort revealed the strongest association of pro-ENK levels with rs1012178 near the PENK gene, where the minor T-allele associated with a 0.057 pmol/L higher pro-ENK level per allele (P=4.67x10<sup>-21</sup>). Furthermore, the T-allele associated with a 19% increased risk of CKD per allele (P=0.03) and a significant decrease in the instrumental variable estimator for eGFR (P<0.01) in a Mendelian randomization analysis. In conclusion, circulating plasma pro-ENK level predicts incident CKD and may aid in identifying subjects in need of primary preventive regimens. Additionally, the Mendelian randomization analysis suggests a causal relationship between pro-ENK level and deterioration of kidney function over time.
Aortic Distensibility and Retinal Arteriolar Narrowing (2007)

Increased aortic stiffness and retinal arteriolar narrowing are subclinical vascular effects of chronic hypertension and predict future cardiovascular events. The relationship between these 2 vascular measures is uncertain and is examined in the Multi-Ethnic Study of Atherosclerosis. This cross-sectional analysis involves 3425 participants (aged 45 to 85 years) free of clinical cardiovascular disease. Retinal vascular caliber was quantified from digital retinal photographs using standardized protocols. Aortic distensibility was determined from chest MRI. After controlling for age, squared age, gender, race, study center, height, weight, heart rate, cigarette smoking, past and current systolic blood pressure, use of antihypertensive medications, diabetes, fasting glucose, lipid profile, and C-reactive protein, reduced aortic distensibility (first versus fourth distensibility quartile) was associated with increased odds of retinal arteriolar narrowing (odds ratio: 1.72; 95% CI: 1.15 to 2.58, comparing lowest to highest quartile of arteriolar caliber). Further adjustments for atherosclerotic measures (carotid intima-media thickness, coronary calcium score, and ankle brachial index) had minimal impact on this association (odds ratio: 1.70; 95% CI: 1.13 to 2.55). Reduced aortic distensibility was not associated with retinal venular caliber. We conclude that increased aortic stiffness is associated with retinal arteriolar narrowing, independent of measured blood pressure levels and vascular risk factors. These data suggest that changes in the microvasculature may play a role linking aortic stiffness with clinical cardiovascular events.
Notes on Feige's gumball machines problem (2009)

We give a detailed proof, in the identically distributed case, of a conjecture of Feige about the maximum probability that the sum of n independent non-negative integer valued random variables, each of mean 1, exceeds n. The general case is reduced to two-point distributions.
Explicit Characterization of Stability Region for Stationary Multi-Queue Multi-Server Systems (2013)

We derive an explicit characterization of the stability region of stationary multi-queue multi-server (MQMS) queueing system by means of a finite set of linear inequalities. More specifically, we explicitly determine the coefficients of the linear inequalities describing the facet-defining hyperplanes of the stability region polytope. Such a characterization is useful for performance evaluation of certain scheduling algorithms such as maximum weight (MW) policy. Our results can be used for studying the asymptotic behavior of the MW policy and computing bounds for the average queueing delay, as well as limiting moments of the queue sizes in heavy-traffic regime. Furthermore, it may be directly applied as the constraint set of network stochastic optimization problems to provide an offline computational solution for such problems. Finally, we use our methodology to characterize the stability region of a fluid model MQMS system which is described by an infinite number of linear inequalities. For such a model, we present an example and show that depending on the channel distribution, the stability region can be instead characterized by a finite set of non-linear inequalities.
Abstract 1354: New chemical tools for disrupting the Mcl-1/BH3 protein-protein interaction (2011)

Abstract Anti-apoptotic members of the Bcl-2 protein family, such as Bcl-2, Bcl-xL and Mcl-1, are among the most effective inhibitors of apoptosis and are frequently upregulated in various types of human cancer. A number of pro-apoptotic proteins share only the BH3 domain with other members of the Bcl-2 family, so called BH3-only proteins, and appear to function essentially as transdominant inhibitors by binding to anti-apoptotic Bcl-2 family proteins and neutralizing their cell-survival activity. The development of small molecules to mimic the BH3 proteins has been an intense area of research. However, to date available Bcl-2 family proteins inhibitors are either pan-inhibitors such as (−)-gossypol (which simultaneously inhibits Bcl-xl/BH3, Bcl-2/BH3 and Mcl-1/BH3 interactions) or are selective for the Bcl-xl/BH3 and Bcl-2/BH3 interactions. Hence a selective Mcl-1/BH3 inhibitor would greatly aid investigating the role of Mcl-1 in cancer and in drug resistance. Our current study is centered on the identification and the synthesis of small molecule selective inhibitors of the Mcl-1/BH3 interaction. To this aim we interrogated the hit-list from inhibitors of the MLSCN screen of the Mcl-1-NOXA interaction [(Emory, AID 1417) TR-FRET screen for Mcl-1-NOXA inhibitors]. Selected compounds were purchased and assessed for activity in a fluorescence polarization and ELISA assay, to reveal the hit HLM050001 (FP IC50 0.8 ± 0.1 µM; ELISA IC50 19.3 ± 2.5 µM). HLM050001binding to Mcl-1 is currently being assessed via co-crystallization and other biophysical techniques. We will report the synthesis and biological evaluation of focused libraries based on the initial hit and designed by modeling and docking to Mcl-1. Structure activity relationship studies around the hit will be disclosed as well as the outcomes of further rounds of chemical design and biological assessment. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1354. doi:10.1158/1538-7445.AM2011-1354
Volumetric imaging of erythrocytes using label‐free multiphoton photoacoustic microscopy (2013)

Photoacoustic microscopy (PAM) is an imaging modality well suited to mapping vasculature and other strong absorbers in tissue. However, one of the primary drawbacks to PAM when used for high-resolution imaging is the relatively poor axial resolution due to the inverse dependence on the transducer bandwidth. While submicron lateral resolution PAM can be achieved by tightly focusing the excitation light, the axial resolution is fundamentally limited to 10s of microns for typical transducer frequencies. Here we present a multiphoton PAM technique called transient absorption ultrasonic microscopy (TAUM), which results in a completely optically resolved voxel with an experimentally measured axial resolution of 1.5 microns. This technique is demonstrated by imaging individual red blood cells in three dimensions in blood smear and ex vivo tissues. To the best of our knowledge, this is the first demonstration of fully resolved, volumetric photoacoustic imaging of erythrocytes.
Improved modeling of system response in list mode EM reconstruction of Compton scatter camera images (2001)

An improved List Mode EM method for reconstructing Compton scattering camera images has been developed. First, an approximate method for computation of the spatial variation in the detector sensitivity has been derived and validated by Monte Carlo computation. A technique for estimating the relative weight of system matrix coefficients for each gamma in the list has also been employed, as has a method for determining the relative probabilities of emission having come from pixels tallied in each list-mode back-projection. Finally, a technique has been developed for modeling the effects of Doppler broadening and finite detector energy resolution on the relative weights for pixels neighbor to those intersected by the back-projection, based on values for the FWHM of the spread in the cone angle computed by Monte Carlo. Memory issues typically associated with list mode reconstruction are circumvented by storing only a list of the pixels intersected by the back-projections, and computing the weights of the neighboring pixels at each iteration step. Reconstructions have been performed on experimental data for both point and distributed sources.
Superoxide Anion Generation, Superoxide Dismutase Activity, and Nitric Oxide Release in Human Internal Mammary Artery and Saphenous Vein Segments (1999)

Background: Internal mammary artery (IMA) as conduit for a coronary artery bypass graft (CABG) stays patent longer and more often than saphenous vein (SV). However, the pre cise differences in the biology of IMA and SV are unclear. Methods and Results: To examine inherent difference in superoxide anion, superoxide dis mutase (SOD) and nitric oxide (NO) formation in IMA and SV as a basis for differences in patency rates, we measured these parameters in vascular segments of patients undergoing CABG. Superoxide anion generation was measured by lucigenin chemiluminescence and reduction of cytochrome c, SOD by inhibition of pyrogallol auto-oxidation, and NO as nitrite/nitrate fluorometrically using 2-3-diaminonaphthalene as a probe. Generation of superoxide anion, SOD activity, and NO formation were all greater in the IMA than in the SV segments (IMA:SV = 2.6:1, 2.9:1, 1, and 3.0:1, respectively, all P &lt; .01). There was a pos itive correlation between superoxide anion generation and SOD activity ( r = 0.65, P &lt; .05; r = 0.70, P &lt; .05 in IMA and SV, respectively) and NO release ( r = 0.68, P &lt; .05; r = 0.75, P &lt; .03 in IMA and SV, respectively). Western blot analysis showed no differences in SOD and NO synthase protein expression in IMA and SV segment homogenates. To examine whether greater superoxide anion generation, SOD activity, and NO formation are unique to IMA, we studied pulmonary artery (PA) and pulmonary vein (PV) segments taken from patients undergoing lung resection. Superoxide anion generation, SOD activity, and NO formation were also found to be greater in PA than in PV segments. Conclusions: Inherently greater superoxide anion generation and subsequently increased formation of SOD and NO release in IMA (vs SV) may be a factor in the greater patency of the former as CABG conduit. Because both IMA and PA are exposed to pulsatile stretch and carry blood at higher pressure than the SV and PV, it is likely that these 2 factors account for the observed differences.
Defect Removal in the Course of Directed Self-Assembly is Facilitated in the Vicinity of the Order-Disorder Transition (2014)

The stability of prototypical defect morphologies in thin films of symmetric diblock copolymers on chemically patterned substrates is investigated by self-consistent field theory. The excess free energy of defects and barriers of defect-removal mechanisms are obtained by computing the minimum free-energy path. Distinct defect-removal mechanisms are illustrated demonstrating that (i) defects will become unstable at a characteristic value of incompatibility χN* above the order-disorder transition and (ii) the kinetics is accelerated at weak segregation. Numerical findings are placed in the context of physical mechanisms, and implications for directed self-assembly are discussed.
Reducing spin torque switching current density by boron insertion into a CoFeB free layer of a magnetic tunnel junction (2012)

The spin torque switching current density is measured for magnetic tunnel junctions containing a CoFeB free layer. We find that the insertion of an ultra-thin boron layer near the free layer/tunnel barrier interface gives rise to an increased resistance-area product and to a reduction in the switching current density. This is attributed to a lower tunneling matrix element near the inserted boron. As a result, the injected current is concentrated within smaller areas of the free layer, which leads to an overall decrease in the switching current density.
An adaptive system identification method on bispectrum (2002)

An adaptive technique for the identification of a linear system which is driven by white non-Gaussian noise is proposed. The system can be a nonminimum phase system. The adaptive identification technique is a least-mean-square type algorithm, and it is obtained by using the higher order cumulants of the system output. A simulation example is given.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Design tradeoffs for tiled CMP on-chip networks (2014)

We develop detailed area and energy models for on-chip interconnection networks and describe tradeoffs in the design of efficient networks for tiled chip multiprocessors. Using these detailed models we investigate how aspects of the network architecture including topology, channel width, routing strategy, and buffer size affect performance and impact area and energy efficiency. We simulate the performance of a variety of on-chip networks designed for tiled chip multiprocessors implemented in an advanced VLSI process and compare area and energy efficiencies estimated from our models. We demonstrate that the introduction of a second parallel network can increase performance while improving efficiency, and evaluate different strategies for distributing traffic over the subnetworks. Drawing on insights from our analysis, we present a concentrated mesh topology with replicated subnetworks and express channels which provides a 24% improvement in area efficiency and a 48% improvement in energy efficiency over other networks evaluated in this study.
A Search for Tick-Associated, Bronnoya-like Virus Spillover into Sheep (2023)

Tick-borne diseases are responsible for many vector-borne diseases within Europe. Recently, novel viruses belonging to a new viral family of the order <i>Bunyavirales</i> were discovered in numerous tick species. In this study, we used metatranscriptomics to detect the virome, including novel viruses, associated with <i>Ixodes ricinus</i> collected from Romania and France. A bunyavirus-like virus related to the Bronnoya virus was identified for the first time in these regions. It presents a high level of amino-acid conservation with Bronnoya-related viruses identified in <i>I. ricinus</i> ticks from Norway and Croatia and with the <i>Ixodes scapularis</i> bunyavirus isolated from a tick cell line in Japan in 2014. Phylogenetic analyses revealed that the Bronnoya viruses' sub-clade is distinct from several <i>Bunyavirales</i> families, suggesting that it could constitute a novel family within the order. To determine if Bronnoya viruses could constitute novel tick-borne arboviruses, a Luciferase immunoprecipitation assay for detecting antibodies in the viral glycoprotein of the Romanian Bronnoya virus was used to screen sera from small ruminants exposed to tick bites. No positive serum was detected, suggesting that this virus is probably not able to infect small ruminants. This study represents the first serological investigation of mammalian infections with a Bronnoya-like virus and an initial step in the identification of potential new emergences of tick-borne arboviruses.
Acute and Chronic Changes in Gene Expression After CMV DNAemia in Kidney Transplant Recipients (2021)

Cytomegalovirus (CMV) viremia continues to cause significant morbidity and mortality in kidney transplant patients with clinical complications including organ rejection and death. Whole blood gene expression dynamics in CMV viremic patients from onset of DNAemia through convalescence has not been well studied to date in humans. To evaluate how CMV infection impacts whole blood leukocyte gene expression over time, we evaluated a matched cohort of 62 kidney transplant recipients with and without CMV DNAemia using blood samples collected at multiple time points during the 12-month period after transplant. While transcriptomic differences were minimal at baseline between DNAemic and non-DNAemic patients, hundreds of genes were differentially expressed at the long-term timepoint, including genes enriching for pathways important for macrophages, interferon, and IL-8 signaling. Amongst patients with CMV DNAemia, the greatest amount of transcriptomic change occurred between baseline and 1-week post-DNAemia, with increase in pathways for interferon signaling and cytotoxic T cell function. Time-course gene set analysis of these differentially expressed genes revealed that most of the enriched pathways had a significant time-trend. While many pathways that were significantly down- or upregulated at 1 week returned to baseline-like levels, we noted that several pathways important in adaptive and innate cell function remained upregulated at the long-term timepoint after resolution of CMV DNAemia. Differential expression analysis and time-course gene set analysis revealed the dynamics of genes and pathways involved in the immune response to CMV DNAemia in kidney transplant patients. Understanding transcriptional changes caused by CMV DNAemia may identify the mechanism behind patient vulnerability to CMV reactivation and increased risk of rejection in transplant recipients and suggest protective strategies to counter the negative immunologic impact of CMV. These findings provide a framework to identify immune correlates for risk assessment and guiding need for extending antiviral prophylaxis.
Reversible Intercalation of Fluoride-Anion Receptor Complexes in Graphite (2007)

We have demonstrated a route to reversibly intercalate fluoride-anion receptor complexes in graphite via a nonaqueous electrochemical process. This approach may find application for a rechargeable lithium–fluoride dual-ion intercalating battery with high specific energy. The cell chemistry presented here uses graphite cathodes with LiF dissolved in a nonaqueous solvent through the aid of anion receptors. Cells have been demonstrated with reversible cathode specific capacity of approximately 80 mAh/g at discharge plateaus of upward of 4.8 V, with graphite staging of the intercalant observed via in situ synchrotron X-ray diffraction during charging. Electrochemical impedance spectroscopy and 11B nuclear magnetic resonance studies suggest that co-intercalation of the anion receptor with the fluoride occurs during charging, which likely limits the cathode specific capacity. The anion receptor type dictates the extent of graphite fluorination, and must be further optimized to realize high theoretical fluorination levels. To find these optimal anion receptors, we have designed an ab initio calculations-based scheme aimed at identifying receptors with favorable fluoride binding and release properties.
Synthesis, preliminary evaluation and molecular modeling studies of new, conformationally constrained analogues of the competitive NMDA receptor antagonist 4-(phosphonomethyl)-2-piperidinecarboxylic acid (CGS 19755). (1998)

Two new spirobicyclophosphonate isomers (19 and 20), conformationally constrained analogues of the potent competitive NMDA antagonist CGS 19755 (4), have been designed and synthetized with the aim of gaining insight into the conformational preference of the crucial distal phosphonate moiety at the antagonist NMDA binding site. The preliminary biological evaluation reveals that the activity as NMDA antagonist resides only in the (1R,5S,7R)-isomer (19), characterized by a (-)-gauche disposition around the C1-C5 bond, thus confirming previously reported pharmacophore models.
Influences on Early Fetal Loss in Dairy Cattle (2003)

Early fetal loss in dairy cattle is a major factor contributing to repeat breeding. If the average fertilization rate in cattle is 85-95% and the incidence of repeat breeders is 56-72% of the herd, then embryonic or early fetal loss (EFL) accounts for 15-25% wastage. It was the purpose of this project to evaluate the effects that changes in body condition score (BCS) and breeding a potentially pregnant cow have on EFL during two periods: between 24-28 days after artificial insemination (AI), and between 28-42 days after AI.
ChemInform Abstract: Synthesis and X‐Ray Structure of Stable 2H‐Isoindoles. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.