gebhart/patrepeval huggingface dataset:
Evaluation of antifungal combination against Cryptococcus spp. (2016)

The second cause of death among systemic mycoses, cryptococcosis treatment represents a challenge since that 5-flucytosine is not currently available in Brazil. Looking for alternatives, this study evaluated antifungal agents, alone and combined, correlating susceptibility to genotypes. Eighty Cryptococcus clinical isolates were genotyped by URA5 gene restriction fragment length polymorphism. Antifungal susceptibility was assessed following CLSI-M27A3 for amphotericin (AMB), 5-flucytosine (5FC), fluconazole (FCZ), voriconazole (VRZ), itraconazole (ITZ) and terbinafine (TRB). Drug interaction chequerboard assay evaluated: AMB + 5FC, AMB + FCZ, AMB + TRB and FCZ + TRB. Molecular typing divided isolates into 14 C. deuterogattii (VGII) and C. neoformans isolates were found to belong to genotype VNI (n = 62) and VNII (n = 4). C. neoformans VNII was significantly less susceptible than VNI (P = 0.0407) to AMB; C. deuterogattii was significantly less susceptible than VNI and VNII to VRZ (P < 0.0001). C. deuterogattii was less susceptible than C. neoformans VNI for FCZ (P = 0.0170), ITZ (P < 0.0001) and TRB (P = 0.0090). The combination FCZ + TRB showed 95.16% of synergistic effect against C. neoformans genotype VNI isolates and all combinations showed 100% of synergism against genotype VNII isolates, suggesting the relevance of cryptococcal genotyping as it is widely known that the various genotypes (now species) have significant impact in antifungal susceptibilities and clinical outcome. In difficult-to-treat cryptococcosis, terbinafine and different antifungal combinations might be alternatives to 5FC.
Probe Molecule Chemisorption−Low Energy Ion Scattering Study of Surface Active Sites Present in the Orthorhombic Mo−V−(Te−Nb)−O Catalysts for Propane (Amm)oxidation (2006)

Methanol and allyl alcohol chemisorption and surface reaction in combination with low energy ion scattering (LEIS) were employed to determine the outermost surface compositions and chemical nature of active surface sites present on the orthorhombic (M1) Mo-V-O and Mo-V-Te-Nb-O phases. These orthorhombic phases exhibited vastly different behavior in propane (amm)oxidation reactions and, therefore, represented highly promising model systems for the study of the surface active sites. The LEIS data for the Mo-V-Te-Nb-O catalyst indicated surface depletion for V (-23%) and Mo (-27%), and enrichments for Nb (+55%) and Te (+165%) with respect to its bulk composition. Only minor changes in the topmost surface composition were observed for this catalyst under the conditions of the LEIS experiments at 400 degrees C, which is a typical temperature employed in these propane transformation reactions. These findings strongly suggested that the bulk orthorhombic Mo-V-Te-Nb-O structure may function as a support for the unique active and selective surface monolayer in propane (amm)oxidation. Moreover, direct evidence was obtained that the topmost surface VO(x) sites in the orthorhombic Mo-V-Te-Nb-O catalyst were preferentially covered by chemisorbed allyloxy species, whereas methanol was a significantly less discriminating probe molecule. The surface TeO(x) and NbO(x) sites on the Mo-V-Te-Nb-O catalyst were unable to chemisorb these probe molecules to the same extent as the VO(x) and MoO(x) sites. Our findings suggested that different surface locations for V(5+) ions in the orthorhombic Mo-V-O and Mo-V-Te-Nb-O catalysts may be primarily responsible for vastly different catalytic behavior exhibited by the Mo-V-O and Mo-V-Te-Nb-O phases. Although the proposed isolated V(5+) pentagonal bipyramidal sites in the orthorhombic Mo-V-O phase may be capable of converting propane to propylene with modest selectivity, the selective 8-electron transformation of propane to acrylic acid and acrylonitrile may require the presence of several surface VO(x) redox sites lining the entrances to the hexagonal and heptagonal channels of the orthorhombic Mo-V-Te-Nb-O phase. The study of allyl alcohol oxidation over the Mo-V-O and Mo-V-Te-Nb-O catalysts further suggested that water plays a critical role during the oxidation of acrolein intermediate to acrylic acid over the orthorhombic (M1 phase) Mo-V-Te-Nb-O catalysts. Finally, the present study strongly indicated that chemical probe chemisorption combined with low energy ion scattering (LEIS) is a novel and highly promising surface characterization technique for the investigation of the active surface sites present in the bulk mixed metal oxides.
Measurement of backscatter factor in single-mode fibres (1981)

The ratio of the backscattered power to the input pulse energy is measured in single-mode optical fibres. The results provide confirmation of single-mode backscatter theory and show that measurement of this ratio can be used to determine xs, the Rayleigh scatter coefficient.
Microelectronics Packaging Application using post-LTCC technology (2011)

The rapid evolution in electronic equipment has created a demand for advanced devices that are flexible, thin, and light in weight. This demand is driving the development of flexible and stretchable electronic devices as a core technology. To produce wearable computers, we need to fabricate functional membranes that contain passive devices such as capacitors and resistors on resin sheets at low temperatures. These sheets can then serve as mounting boards for various electronic devices. By improving the technique for room-temperature aerosol deposition (ASD) of a ceramic material (post-LTCC technology), we have established a technology for forming a dielectric inorganic film with an excellent degree of crystallinity and favorable electric properties for use in the production of flexible and stretchable electronic devices on a polyimide sheet. In the barium titanate film produced by the deposition on a polyimide sheet, a closely packed film with a high degree of sealing was formed by means of structure control to establish large-particle anchors, measuring about 100 nm in diameter, at the interface between the ceramic film and the polyimide sheet. The maximum dielectric constant of a film of barium titanate formed on the polyimide sheet by using the improved aerosol-deposition was 350 .By using this method to form a three-dimensional capillary structure inside a film, we produced a capacitor film with an apparent dielectric constant of 40,000 at room temperature. We also demonstrate cathode films for quick-charging lithium ion batteries. To achieve rapid charging, it is necessary to improve the speed of the chemical reaction between the cathode material and the electrolyte. Our process, however, does not require any unnecessary additive, such as a binder, unlike conventional tape casting method, and forms a film consisting of nano-particles of a high crystallinity, and is therefore effective for rapid charging.
A simple and compliant force sensing palm for the MLab Simple Hand (2013)

Sensing the forces applied to the palm of a robot manipulator requires robust compliant sensors guarded against collision. The force sensing palm for the MLab Simple Hand measures three components of net contact force in a simple robust design using flexure springs and optical position sensing. The hand is calibrated in an automatic process. Measurements are included to compare performance to the theoretical model.
All-Digital PLL With Ultra Fast Settling (2007)

A fully digital frequency synthesizer for RF wireless applications has recently been proposed. At its foundation lies a digitally controlled oscillator with sufficiently fine frequency resolution to avoid analog tuning. The conventional phase/frequency detector, charge pump and RC loop filter are replaced by a time-to-digital converter and a simple digital loop filter. When implemented in highly scaled digital CMOS processes, the proposed architecture is more advantageous over conventional charge-pump-based phase-locked loops (PLLs) since it exploits signal processing capabilities of digital circuits and avoids relying on the fine voltage resolution of analog circuits. In this brief, we present novel techniques used in the all-digital PLL to achieve an ultra-fast frequency acquisition of <50 mus while maintaining excellent phase noise and spurious performance during transmission and reception. This approach has been validated and incorporated in commercial single-chip Bluetooth and Global System for Mobile Communications radios realized in deep-submicrometer CMOS
Cytomegalovirus Reactivation in Haploidentical Blood or Marrow Transplant (BMT) Using Post-Transplant Cyclophosphamide (PTCy) Is Associated with Higher Non-Relapse-Related Mortality, Despite Rarity of Disease (2018)

Abstract Introduction : CMV infection is associated with direct and indirect morbidities in BMT recipients. Understanding cumulative morbidity associated with infections is difficult, as time-to-first event analyses do not represent recurrent events. We characterized infectious outcomes and non-relapse mortality (NRM) in a large cohort of haploidentical BMT recipients at Johns Hopkins Hospital (JHH) using novel analytic methods to detail recurrent events and estimate cumulative risks. Material and Methods : Demographics, transplant variables, CMV reactivation (DNAemia) and disease, and other outcomes (infections, GVHD and hospitalizations) were collected on sequential haploidentical BMT recipients at JHH (2004-2015). Infectious events were longitudinally depicted. Cox proportional hazards models were used to estimate effects of infections on 1-year survival, adjusted for age, disease related index (DRI), GVHD, time to engraftment, and transplant year. Survival and NRM differences were assessed by Kaplan Meier and competing risks functions, respectively. Results:683 people who received non-myeloablative haploidentical BMT using PTCy, mycophenolate and tacrolimus were included. CMV reactivation occurred in 268 (39%), with organ disease documented in 19 (2.8%). Recurrent reactivation was recorded in 83 (12% of cohort), predominating in seropositive recipients of negative donors (D-/R+). Neutropenia occurred in 24/123 (28%) of subjects with ganciclovir-treated 1st reactivation, increasing to 41% and 60% with 2nd and 3rd episodes. Patients who had CMV reactivation had higher mean numbers of bacteremias (0.48 vs. 0.36, p=0.006), clinical pneumonias (0.24 vs. 0.18, p= 0.03) invasive fungal infections (IFI, 0.23 vs. 0.15, p= 0.05), non-CMV viral infections (0.53 vs. 0.39, p=0.008), and hospitalizations (1.68 vs. 1.27, p=0.001). Patients with CMV reactivation had lower 1-year survival (68% vs. 76%, p=0.016), with higher NRM in competing risk analyses. Associations between CMV reactivation and other infections were appreciated in longitudinal analyses. In regression analysis, risks for death were associated with DRI (HR 4.3 - 2.5, p&lt;0.001), older age (HR 1.1, p=0.02), IFI (HR 1.7, p=0.003), pneumonias (HR 1.9, p&lt;0.001), and bacteremias (HR 1.7, p&lt;0.001). Conclusion: CMV reactivation and recurrence is common in seropositive haploidentical BMT recipients, especially with seronegative donors, but disease is rare. Longitudinal modeling of reactivation and treatment-associated neutropenia suggests that reactivation is implicated in secondary infections that increase risks for death. These findings may instruct better-targeted prophylaxis strategies. Disclosures Marr: MycoMed Technologies: Consultancy, Equity Ownership, Patents &amp; Royalties.
ChemInform Abstract: Total Synthesis of Calicheamicinone: New Arrangements for Actuation of the Reductive Cycloaromatization of Aglycon Congeners. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Tables S1, S2, S3, S4, S5. Figures S1, S2. from Angiogenic Factor and Cytokine Analysis among Patients Treated with Adjuvant VEGFR TKIs in Resected Renal Cell Carcinoma (2023)

&lt;p&gt;Supplemental Table 1: Catalog numbers for MSD assays Supplemental Figure 1: Hazard ratio for CXCL10 and DFS by treatment arm Supplemental Figure 2: Assessment of log-linearity for relationship between IP-10 and recurrence risk Supplemental Table 2: Median changes in cytokines at weeks 4 and 6 Supplemental Table 3: Relationship between on-treatment cytokine levels and DFS Supplemental Table 4: Subset analysis for cytokine changes among patients who did not recur Supplemental Table 5: Evaluation for interaction effects between treatment arm and the association between baseline CXCL10 and DFS&lt;/p&gt;
Quantitative Analysis of Step-Growth Polymers by Size Exclusion Chromatography (2016)

We report an advanced analysis protocol that allows to quantitatively study the course of step-growth reactions by size exclusion chromatography on the example of the depolymerization of a Diels-Alder polymer based on a furane/maleimide couple at elevated temperatures. Frequently occurring issues of molar mass calibrations and overlap of monomer with solvent signals are addressed for determining reliable molar masses. Thereby, even kinetic parameters (e.g., rate coefficients) can be derived that otherwise would require performing additional spectroscopic experiments. Our results confirm first-order behavior of the rDA reaction with an activation energy of 33 kJ mol<sup>-1</sup>.
Data Center Energy Efficiency and Renewable Energy Site Assessment: Anderson Readiness Center; Salem, Oregon (2014)

This report summarizes the results from the data center energy efficiency and renewable energy site assessment conducted for the Oregon Army National Guard in Salem, Oregon. A team led by NREL conducted the assessment of the Anderson Readiness Center data centers March 18-20, 2014 as part of ongoing efforts to reduce energy use and incorporate renewable energy technologies where feasible. Although the data centers in this facility account for less than 5% of the total square footage, they are estimated to be responsible for 70% of the annual electricity consumption.
Light-induced director-controlled microassembly of dye molecules from a liquid crystal matrix (1999)

We report on a light-induced phenomenon in dye-doped liquid crystals (LCs) with the distinctive features of molecular transport and assembly at micron scales. Under single-beam laser irradiation, the dye molecules phase separate from the LC host and assemble onto the cell substrate. Although the intensity of incident light is uniform within the irradiated area, the density of the adsorbed dye is modulated in accord with the director modulation of the LC. The dye molecules form a surface imprint that portrays orientational distortions of the LC host.
Contrasting Mechanisms of Interferon‐α Inhibition by Intravenous Immunoglobulin After Induction by Immune Complexes Versus Toll‐like Receptor Agonists (2013)

IgG attenuates IFNα production by PDCs by both cell surface receptor and intracellular pathways, depending on the nature of the inducing stimulus.
GroEL/ES inhibitors as potential antibiotics (2016)

We recently reported results from a high-throughput screening effort that identified 235 inhibitors of the Escherichia coli GroEL/ES chaperonin system [Bioorg. Med. Chem. Lett.2014, 24, 786]. As the GroEL/ES chaperonin system is essential for growth under all conditions, we reasoned that targeting GroEL/ES with small molecule inhibitors could be a viable antibacterial strategy. Extending from our initial screen, we report here the antibacterial activities of 22 GroEL/ES inhibitors against a panel of Gram-positive and Gram-negative bacteria, including E. coli, Bacillus subtilis, Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter cloacae. GroEL/ES inhibitors were more effective at blocking the proliferation of Gram-positive bacteria, in particular S. aureus, where lead compounds exhibited antibiotic effects from the low-μM to mid-nM range. While several compounds inhibited the human HSP60/10 refolding cycle, some were able to selectively target the bacterial GroEL/ES system. Despite inhibiting HSP60/10, many compounds exhibited low to no cytotoxicity against human liver and kidney cell lines. Two lead candidates emerged from the panel, compounds 8 and 18, that exhibit >50-fold selectivity for inhibiting S. aureus growth compared to liver or kidney cell cytotoxicity. Compounds 8 and 18 inhibited drug-sensitive and methicillin-resistant S. aureus strains with potencies comparable to vancomycin, daptomycin, and streptomycin, and are promising candidates to explore for validating the GroEL/ES chaperonin system as a viable antibiotic target.
Web-conference supervision for advanced psychotherapy training: A practical guide. (2011)

The advent of readily accessible, inexpensive Web-conferencing applications has opened the door for distance psychotherapy supervision, using video recordings of treated clients. Although relatively new, this method of supervision is advantageous given the ease of use and low cost of various Internet applications. This method allows periodic supervision from point to point around the world, with no travel costs and no long gaps between direct training contacts. Web-conferencing permits face-to-face training so that the learner and supervisor can read each other's emotional responses while reviewing case material. It allows group learning from direct supervision to complement local peer-to-peer learning methods. In this article, we describe the relevant literature on this type of learning method, the practical points in its utilization, its limitations, and its benefits.
Multi timescale bandwidth profile and its application for burst-aware fairness (2019)

We propose a resource sharing scheme that takes into account the traffic history over several predefined time scales and provides fair resource sharing considering the traffic history. Our concept builds on a simplified version of core-stateless resource sharing, where we only use a few Drop Precedences (DPs). For packet marking we introduce Multi timescale bandwidth profile. Additionally, we provide basic dimensioning concepts for the proposed schema and present its simulation based performance analysis.
Remote Sensing of High Temperatures with Refractory, Direct-Contact Optical Metacavity (2020)

In this work, temperature-dependent optical properties of refractory plasmonic transition metal nitrides and dielectric thin films are utilized to design and realize a planar, direct-contact, nanophotonic metacavity for remote, all-optical sensing of a wide range of surface temperatures (from room temperature to above 1000 °C). The proposed hybrid metacavity device integrates the plasmonic cavity with a planar metasurface that utilizes refractory material components, namely, titanium nitride (TiN) and silicon nitride (Si3N4), and operates in a spectral wavelength window of 900–1400 nm. The unique feature of this approach is that metacativy is located directly on the hot surface, while other components are kept remote. The thermally variant optical properties of the constituent materials (TiN, Si3N4) enable metacavity operation with a strong polarization-dependent resonant reflectance response. At the cavity resonance, relative amplitude variations of above 30% are detected in the temperature-dependent reflectance spectra that act as the read-out from the experimentally demonstrated sensor. The proposed high-efficiency, planar optical refractory sensor located directly on hot surfaces also allows for great scalability. The device enables true remote all-optical measurements by keeping other ancillary systems outside of the hot ambient conditions and, therefore, is especially relevant for applications in harsh environments.
Introduction to the BIOMED 2012 Feature Issue (2012)

The guest editors introduce a feature issue containing papers based on research presented at the BIOMED 2012 conference.
Stable amorphous georgeite as a precursor to a high activity catalyst (2016)

The dataset is related to the preparation of synthetic georgeite (a copper-zinc hydroxycarbonate) and its use as a catalyst precursor for the methanol synthesis and low temperature water gas shift reactions. Included is data on the characterisation of the precursor and catalyst. This includes pair distribution analysis, raw X-ray absorption fine-structure measurements, X-ray diffraction measurements, infra-red spectroscopy, and thermogravimetric analysis data in excel files, with text headers. Environmental transmission electron microscopy images are provided in dm3 file format. In addition methanol synthesis and water gas shift testing data is provided in an excel file.
On the impact of network geometric models on multicell cooperative communication systems (2013)

Recognized as an efficient technology allowing enhanced high-data-rate coverage, multicell cooperation builds on collaborative operation of distributed network elements aiming to reduce the impact of intercell interference, or even to exploit it as a source of additional information. However, performance gains arising from this collaboration come at a price of increased complexity and coordination among involved network elements. An immediate question is how to adequately model a multicell cooperative network, while striking the balance between analytic complexity and precision of design decisions. In this article we highlight two categories of multicell network models, Wyner models and random network models, and their impact on the design and analysis of MCC systems. Recent examples of realistic yet tractable multicell network models are discussed.
N ‐chlorotaurine, a potent weapon against multiresistant bacteria (2021)

The bactericidal spectrum of NCT is not restricted by resistance against antibiotics. Therefore, it can be used against resistant strains, too.
Large-scale CAD Model Visualization on a Scalable Shared-memory Architecture (2005)

In this work we propose a novel approach for realistic fire animation and manipulation. We apply a statistical learning method to an image sequence of a real-world flame to jointly capture flame motion and appearance characteristics. A low-dimensional generic flame model is then robustly matched to the video images. The model parameter values are used as input to drive an Expectation-Maximization algorithm to learn an {\\em auto regressive process} with respect to flame dynamics. The generic flame model and the trained motion model enable us to synthesize new, unique flame sequences of arbitrary length in real-time.
Oxygen Generator Cell Design for Future Submarines (1996)

&lt;div class="htmlview paragraph"&gt;The extended deployment of strategic deterrent submarines necessitated the onboard generation of respirable oxygen through electrolysis of water. Proton exchange membrane cells capable of generating oxygen at up to 1,600 milliamperes per square centimeter of cell surface area are currently in production. Recent technical advances allow submarines to utilize higher differential pressure cell stacks to permit the direct discharge of system fluids at submerged pressure while maintaining breathing oxygen at ambient pressure. Further developments permit the direct electrochemical reduction of carbon dioxide and the production of respirable oxygen in one electrochemical cell. This paper reports the improved performance of the upgraded SPE&lt;sup&gt;®&lt;/sup&gt; electrolyzer configuration and preliminary performance data of the Submarine Advanced Integrated Life Support (SAILS) system for carbon dioxide reduction.&lt;/div&gt;