gebhart/patrepeval huggingface dataset:
Abstract 1468: Synergistic cancer immunotherapy combination of MVA-CD40L with tumor targeting antibodies or checkpoint blockade to achieve strong antitumor immune responses against large, established tumors (2019)

Abstract Virus-based vaccines and appropriate costimulation potently enhance antigen-specific T cell immunity against cancer. In the present study, we exploit both innate and adaptive immune responses triggered by recombinant modified vaccinia virus Ankara (rMVA) encoding costimulatory CD40L against large, established tumors in different combinatory settings. Therapeutic treatment with rMVA-CD40L resulted in the control or eradication of solid tumors in several unrelated tumor models. The expansion of non-exhausted, tumor-specific cytotoxic CD8+ T cells was essential for the therapeutic activity and was partially dependent on CD8α+ cross-presenting dendritic cells. Combination of rMVA-CD40L with PD-1 checkpoint blockade further enhanced the therapeutic activity of MVA virotherapy in colorectal carcinoma. In addition, rMVA-CD40L combined with antibodies targeting Tumor-Associated Antigens (TAA) resulted in increased therapeutic antitumor efficacy against two unrelated tumor models. We describe a translationally relevant therapeutic synergy between viral vaccination and CD40L costimulation. We show strengthened antitumor immune responses when both rMVA-CD40L-induced innate and adaptive immune mechanisms are exploited by combining immunotherapeutic regimes, such as checkpoint blockade and TAA targeting antibodies. This novel immunotherapeutic approach could translate into clinical cancer therapies where ADCC competent TAA targeting antibodies PD-1 checkpoint blockade are employed. Citation Format: Jose Medina-Echeverz, Maria Hinterberger, Raphael Giessel, Barbara Bathke, Ronny Kassub, Giovanna Fiore, Paul Chaplin, Hubertus Hochrein, Henning Lauterbach. Synergistic cancer immunotherapy combination of MVA-CD40L with tumor targeting antibodies or checkpoint blockade to achieve strong antitumor immune responses against large, established tumors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1468.
Un équivalent particulaire de l'équation de Kuramoto-Sivashinsky (2011)

International audience
EMERGENT Project: ChiplEss MultisEnsor Rfid for GrEen NeTworks (2019)

This work summarizes the main outcomes of the EMERGENT project that was mainly focused on the design of chipless RFID sensors and their realization on green substrates. Three different sensors are presented for monitoring humidity, temperature and breathing.
Supplementary Figure S5 from Small-Molecule Prodigiosin Restores p53 Tumor Suppressor Activity in Chemoresistant Colorectal Cancer Stem Cells via c-Jun-Mediated ΔNp73 Inhibition and p73 Activation (2023)

&lt;p&gt;Prodigiosin-mediated p53 pathway restoration, cell death and anti-CRCSC effect involves inhibition of Î”Np73.&lt;/p&gt;
Segmented-core fiber for long-haul and local-area-network applications (1988)

Design and experimental results for a segmented-core fiber optimized for long-haul and local-area-network applications are presented. It is compatible with existing dispersion nonshifted fibers above 1300 nm and has high bandwidth (2-4 GHz) over a wide wavelength range in the so-called few mode region near 800 nm. At this wavelength it also provides at least an additional 4.8-dB system margin compared to a single-mode fiber.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Chemokine repulsion of autoimmune T cell adhesion (2006)

Leukocyte recruitment into pancreatic islets is believed to play an important pathophysiological role in autoimmune diabetes. Previous reports have suggested that the chemokine stromal‐cell derived factor‐1 (SDF‐1) controls maturation, trafficking, and homing of certain subsets of lymphoid cells including immunogenic B and T cells. Moreover, SDF‐1 has been shown to be either chemo‐attractant or ‐repellant depending on concentration. Here we examined the hypothesis that SDF‐1 regulates the adhesion of autoimmune lymphocytes to islet microvascular endothelium in autoimmune diabetes. Islet microvascular endothelial cell monolayers were stimulated with 10 ng/ml TNFα and subsequently coated with varying concentrations of SDF‐1 (1 ng/ml, 50 ng/ml and 100 ng/ml) and subjected to parallel plate flow chamber analysis for T‐cell/endothelial cell interactions. TNFα stimulation alone caused a 2 fold increase in NOD CD3+ T‐cell adhesion, which was completely blocked by 100 ng/ml SDF‐1. However, 50 ng/ml SDF‐1 elicited a slight but significant increase in adhesion, while 1 ng/ml SDF‐1 treatment had no affect on TNFα stimulated adhesion. In contrast, SDF‐1 treatment did not demonstrate a chemorepulsive effect on TNFα stimulated C57BL/6J CD3+ T‐cell adhesion. Moreover, the chemorepulsive effect of SDF‐1 on TNFα stimulated NOD CD3+ T‐cell adhesion was blocked by the G‐protein coupled receptor antagonist Pertussis Toxin (100 ng/ml). These data illustrate a novel function for SDF‐1 in mediating chemorepulsion of autoimmune T cells suggesting that SDF‐1 may be useful in disrupting leukocyte recruitment into pancreatic islets seen in autoimmune diabetes.
Syntheses, Crystal Structures, and Physical Properties of La5Cu6O4S7 and La5Cu6.33O4S7 (2008)

Single crystal and bulk powder samples of the quaternary lanthanum copper oxysulfides La5Cu6.33O4S7 and La5Cu6O4S7 have been prepared by means of high-temperature sealed-tube reactions and spark plasma sintering, respectively. In the structure of La 5Cu6.33O4S7, Cu atoms tie together the fluorite-like (2)infinity[La5O4S(5+)] and antifluorite-like (2) infinity[Cu6S6(5-)] layers of La5Cu6O4S7. The optical band gap, E g, of 2.0 eV was deduced from both diffuse reflectance spectra on a bulk sample of La5Cu6O4S7 and for the (010) crystal face of a La 5Cu6.33O4S7 single crystal. Transport measurements at 298 K on a bulk sample of La 5Cu 6O 4S 7 indicated p-type metallic electrical conduction with sigma electrical =2.18 S cm(-1), whereas measurements on a La 5Cu6.33O4S7 single crystal led to sigma electrical =4.5 10(-3) S cm(-1) along [100] and to semiconducting behavior. In going from La 5Cu6O4S7 to La5Cu6.33O4S7, the disruption of the (2)infinity[Cu6S6(5-)] layer and the decrease in the overall Cu(2+)(3d(9)) concentration lead to a significant decrease in the electrical conductivity.
Molecular-level mechanisms of nanoparticle detachment in laser-induced plasma shock waves (2006)

Detachment and detachment mechanisms of nanoparticles from flat surfaces subjected to shock waves are investigated by employing molecular gas dynamic simulations using the direct simulation Monte Carlo method and experimental transient pressure data. Two mechanisms for nanoparticle detachment based on rolling moment resistance of the adhesion bond and the elastic restitution effect are introduced. As a result of present simulations, it is computationally demonstrated that the pulsed laser-induced shock waves can generate sufficient rolling moments to detach sub-100-nm particles and initiate removal. The transient moment exerted on a 60nm polystyrene latex particle on a silicon substrate is presented and discussed.
Universal Suzuki–Miyaura Catalyst-Transfer Polymerization for Precision Synthesis of Strong Donor/Acceptor-Based Conjugated Polymers and Their Sequence Engineering (2021)

Catalyst-transfer polymerization has revolutionized the field of polymer synthesis due to its living character, but for a given catalyst system, the polymer scope is rather narrow. Herein we report a highly efficient Suzuki-Miyaura catalyst-transfer polymerization (SCTP) that covers a wide range of monomers from electron-rich (donor, D) to electron-deficient (acceptor, A) (hetero)arenes by rationally designing boronate monomers and using commercially available Buchwald RuPhos and SPhos Pd G3 precatalysts. Initially, we optimized the controlled polymerization of 3,4-propylenedioxythiophene (ProDOT), benzotriazole (BTz), quinoxaline (QX), and 2,3-diphenylquinoxaline (QXPh) by introducing new boronates, such as 4,4,8,8-tetramethyl-1,3,6,2-dioxazaborocane and its <i>N</i>-benzylated derivative, to modulate the reactivity and stability of the monomers. As a result, PProDOT, PBTz, PQX, and PQXPh were prepared with controlled molecular weight and narrow dispersity (<i>Đ</i> < 1.29) in excellent yield (>85%). A detailed investigation of the polymer structures using <sup>1</sup>H NMR and MALDI-TOF spectrometry supported the chain-growth mechanism and the high initiation efficiency of the SCTP method. In addition, the use of RuPhos-Pd showing excellent catalyst-transfer ability on both D/A monomers led to unprecedented controlled D-A statistical copolymerization, thereby modulating the HOMO energy level (from -5.11 to -4.80 eV) and band gap energy (from 1.68 to 1.91 eV) of the resulting copolymers. Moreover, to demonstrate the living nature of SCTP, various combinations of D-A and A-A block copolymers (PBTz-<i>b</i>-PProDOT, PQX-<i>b</i>-PProDOT, and PQX-<i>b</i>-PBTz) were successfully prepared by the sequential addition method. Finally, simple but powerful one-shot D-A block copolymerization was achieved by maximizing the rate difference between a fast-propagating pinacol boronate donor and a slow-propagating acceptor to afford well-defined poly(3-hexylthiophene)-<i>b</i>-poly(benzotriazole).
Large-scale polysilicon surface-micromachined spatial light modulator (2003)

A large-scale, high speed, high resolution, phase-only microelectromechanical system (MEMS) spatial light modulator (SLM) has been fabricated. Using polysilicon thin film technology, the micro mirror array offers significant improvement in SLM speed in comparison to alternative modulator technologies. Pixel opto-electromechanical characterization has been quantified experimentally on large scale arrays of micro mirrors and results are reported.
Knock Sensor Based Virtual Combustion Sensor Signal Bias Sensitivity (2018)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;The combustion in a direct injected internal combustion engine is normally open-loop controlled. The introduction of cylinder pressure sensors enables a virtual combustion sensor which in turn enables closed-loop combustion control, and the possibility to counteract effects such as engine part-to-part variation, component ageing and fuel quality diversity.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;Closed-loop combustion control requires precise, robust and preferably cheap sensors. This paper presents an investigation of the robustness and the limitation of a knock sensor based virtual combustion sensor. This virtual combustion sensor utilize the common heat release analysis using a knock sensor based virtual cylinder pressure signal.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;Major virtual sensor error sources in a heavy-duty engine were identified as: the specific heat ratio model, the boost pressure and the crank angle phasing. The virtual sensor errors were quantified in relation to both the measured cylinder pressure and the total virtual sensor error.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;The tolerance analysis of the virtual sensor showed the signals of the crank angles 10% and 50% heat release as robust with low sensitivity to errors. An additional dependency found for the crank angle of 10% heat release was the compression ratio error.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;The study concluded that it is possible to estimate the mass fraction of 10% and 50% heat release accurately enough to make the virtual sensor an option for closed loop combustion control.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;The study was not able to prove the virtual sensor cylinder pressure signal, crank angle of burned fractions signals or total heat release signal capable of confident determination of the amount of biodiesel in fossil diesel.&lt;/div&gt;&lt;/div&gt;
Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis (2016)

Rheumatoid arthritis (RA) affects millions world-wide. While anti-TNF treatment is widely used to reduce disease progression, treatment fails in ∼one-third of patients. No biomarker currently exists that identifies non-responders before treatment. A rigorous community-based assessment of the utility of SNP data for predicting anti-TNF treatment efficacy in RA patients was performed in the context of a DREAM Challenge (http://www.synapse.org/RA_Challenge). An open challenge framework enabled the comparative evaluation of predictions developed by 73 research groups using the most comprehensive available data and covering a wide range of state-of-the-art modelling methodologies. Despite a significant genetic heritability estimate of treatment non-response trait (h(2)=0.18, P value=0.02), no significant genetic contribution to prediction accuracy is observed. Results formally confirm the expectations of the rheumatology community that SNP information does not significantly improve predictive performance relative to standard clinical traits, thereby justifying a refocusing of future efforts on collection of other data.
Kerr-lens mode-locked femtosecond polycrystalline Cr^2+:ZnS and Cr^2+:ZnSe lasers (2014)

We report the first Kerr-lens mode-locked polycrystalline Cr(2+):ZnS and Cr(2+):ZnSe lasers, with pulse duration of 125 fs at a pulse repetition rate of 160 MHz, emitting around 2.3 - 2.4 µm. The mode-locked lasers were pumped by a radiation of 1550 nm Er-fiber amplifier seeded by semiconductor laser. The long-term stable Kerr-lens mode-locked laser operation with the output power of 30 mW (Cr(2+):ZnS) and 60 mW (Cr(2+):ZnSe) was obtained. We also demonstrate amplification of the fs laser pulse train in a cw pumped single-pass polycrystalline Cr(2+):ZnS laser amplifier.
Two-Photon Luminescence of Gold Nanorods Mediated by Higher Order Plasmon Modes (2015)

Metallic nanorod antennas can be considered as an analogue to classical half-wave dipole antennas, constituting an important tool for manipulating linear and nonlinear light-matter interactions in nanoscale volumes. Using two-photon luminescence (TPL) scanning laser microscopy, we investigate such optical antennas beyond their fundamental dipole mode. The antenna mode dispersion is extracted from the nonlinear TPL measurement and reveals a TPL process that is dominated by plasmon-induced enhancement of the two-photon absorption in the metal. Additionally, a clear signature of the mode parity is observed in the TPL images. TPL maxima are observed outside the antenna boundaries for even parity modes, whereas they are located inside for odd modes. It is concluded that for even modes the two-photon luminescence emission is strongly mediated by retardation of the excitation field, a consequence of their zero net-dipole moment. This selective excitation of different mode parities is highly relevant for nanoscale enhanced nonlinear optics, as well as plasmonic nanosensor applications and tuning of radiative properties of quantum emitters.
Cloud Update of Geodetic Normal Distribution Map Based on Crowd-Sourcing Detection against Road Environment Changes (2022)

LiDAR-based localization has been widely used for the pose estimation of autonomous vehicles. Since the localization requires a sustainable map reflecting environment changes, a map update framework based on crowd-sourcing measurements has been researched. Unfortunately, a point cloud map occupies too large data size to transmit data in the uploading and downloading of the map update framework. To realize the LiDAR map update framework by reducing the data size, we proposed a novel map update framework using a Geodetic Normal Distribution (GND) map that compresses the point cloud to the normal distributions. The proposed GND map update framework comprises two parts: map change detection based on crowd-sourcing vehicles and map updating based on a map cloud server. GND map changes are detected based on an evidence theory considering geometric relationships between the GND map and crowd-sourcing measurements and uploaded to the map cloud server. Uploaded map changes reproduce representative map changes based on a similarity-based clustering, which are updated into the GND map. The proposed framework was evaluated in simulations and real environments on construction sites. As a result, although partial map changes occurred, the GND map was kept up-to-date through the proposed framework and the localization for autonomous driving was performed successfully.
Enhancing catalytic epoxide ring-opening selectivity using surface-modified Ti3C2T x MXenes (2021)

Abstract MXenes are a new family of two-dimensional carbides and/or nitrides. Their 2D surfaces are typically terminated by O, OH and/or F atoms. Here we show that Ti 3 C 2 T x —the most studied compound of the MXene family—is a good acid catalyst, thanks to the surface acid functionalities. We demonstrate this by applying Ti 3 C 2 T x in the epoxide ring-opening reaction of styrene oxide (SO) and its isomerization in the liquid phase. Modifying the MXene surface changes the catalytic activity and selectivity. By oxidizing the surface, we succeeded in controlling the type and number of acid sites and thereby improving the yield of the mono-alkylated product to &gt;80%. Characterisation studies show that a thin oxide layer, which forms directly on the Ti 3 C 2 T x surface, is essential for catalysing the SO ring-opening. We hypothesize that two kinds of acid sites are responsible for this catalysis: In the MXene, strong acid sites (both Lewis and Brønsted) catalyse both the ring-opening and the isomerization reactions, while in the Mxene–TiO 2 composite weaker acid sites catalyse only the ring-opening reaction, increasing the selectivity to the mono-alkylated product.
ChemInform Abstract: TOTALLY SYNTHETIC HEME PROTEIN MODELS BASED ON COMPLEXES WITH SUPERSTRUCTURE LIGANDS (1979)

Abstract Ausgehend von dem ungewöhnlichen Zwischenprodukt (I), das durch die Methoxygruppe an einem Vinylkohlenstoffatom zu Additions‐Eliminierungsreaktionen befähigt ist, wurde durch Reaktion mit a,a′‐Diamino‐p‐xylol der Komplex (II) dargestellt, der in der Raumgruppe Pmn21 mit Z=2 kristallisiert.
Virtual Reality Exposure to a Healthy Weight Body Is a Promising Adjunct Treatment for Anorexia Nervosa (2023)

VR exposure is a well-accepted and powerful tool for evoking fear of weight gain in patients with AN. We observed a statistical trend that repeated virtual exposure to healthy weight improved fear of weight gain with large effect sizes. Further studies are needed to determine the mechanisms and differential effects.
Optical Waveguide SHG Devices Using LiNbO3 Epitaxial Grown and Ultraprecision Machining Technique. (2000)

Quasi-phase-matched second-harmonic generation (QPM-SHG) devices using LiNbO3 optical waveguides show great potential as low noise and high beam quality blue-violet light sources applicable for high-density optical disks. Optical waveguides with a step index profile are desired for achieving strong confinement and sufficient overlap between the propagation modes in order to realize a high conversion efficiency. Liquid phase epitaxy of LiNbO3 is a novel technique which yields a step index thin-film waveguide structure by doping ZnO in the film. Ultraprecision machining is a powerful technique for processing three-dimensional optical waveguides. The maximum SHG power of 50 mW at 425 nm wavelength was obtained using a ridgetype waveguide device which was fabricated from a periodically domain-inverted MgO: LiNbO3 crystal by ultraprecision machining.
Simple and monolithic picosecond pulse shaper based on fiber Bragg gratings (2010)

In this contribution we present a simple and robust pulse shaping device based on coherent pulse stacking. The device is based on fiber Bragg gratings written in a polarisation maintaining step index fiber and a fiber optical circulator. Up to four pulse replicas are reflected by fiber Bragg gratings and interfere at the output of the device. Temperature control allows tuning of the relative pulse amplitudes and phases of the pulse replicas. We experimentally demonstrated 235 ps and 416 ps long flattop pulses with rising and falling edges shorter than 100 ps. In contrast to other pulse shaping techniques the presented setup is robust, alignment free, provides excellent beam quality and is also suitable for pulse durations up to several nanoseconds.
Statistics of polarization dependant gain in Raman fiber amplifiers due to PMD (2001)

Summary form only given. With the recent availability of high power pump lasers, Raman amplification has become feasible for commercial DWDM fiber-optic communication systems. Raman fiber amplifiers are highly attractive for their low equivalent noise figure and wideband gain. However, the Raman gain coefficient is polarization sensitive and can be up to 10 times higher when the signal and pump polarization states are parallel rather than perpendicular. Previous studies of this polarization dependent gain (PDG) investigate its relationship with the polarization mode dispersion (PMD) of the fiber, and the degree of the polarization (DOP) of the pump laser. These studies show that when the average PMD of the fiber becomes high enough, or if the pump DOP is very low, then the PDG becomes negligible. But these studies do not investigate the statistical behavior of the polarization dependant gain. There are two ways of characterizing polarization sensitivity in Raman amplifiers. One is to measure the PDG at a given point in time, which is determined by varying either the pump or signal polarization and recording the difference between the maximum and minimum gains. Alternatively, one can monitor how the instantaneous gain varies over time due to both PMD induced variations and changes to the signal's input state of polarization (SOP). In the paper we investigate the statistical characteristics of both of these parameters theoretically and experimentally.
Detection of colorectal polyps with CT colography: initial assessment of sensitivity and specificity. (1997)

PURPOSE: To estimate the sensitivity and specificity of computed tomographic (CT) colography in detection of colorectal polyps and to compare these findings with those at axial CT. MATERIALS AND METHODS: In 70 consecutive patients, CT colography and colonoscopy were performed. Helical axial CT images and CT colographic images (multiplanar two- and three-dimensional endoluminal images) were evaluated separately by two radiologists blinded to results from colonoscopy and other imaging studies. Findings were compared with those at colonoscopy, which was the standard. RESULTS: The sensitivity and specificity for the two observers with CT colography averaged 75% and 90% in patients with adenomas 10 mm in diameter or larger, 66% and 63% in patients with adenomas 5 mm in diameter or greater, and 45% and 80% for patients with adenomas less than 5 mm in diameter, respectively. Sensitivity and specificity with axial CT were lower than those with CT colography (58% and 74%, respectively) in patients with adenomas 10 mm in diameter or larger. CONCLUSION: Compared with axial CT, CT colography appears to have superior sensitivity and specificity in detection of clinically important colorectal adenomas. Early performance of CT colography seems promising for detection of colorectal polyps 5 mm and larger.