gebhart/patrepeval huggingface dataset:
A Power Management Approach for Laterally-Arrayed Multi-Bandgap Concentrated Photovoltaic Systems (2019)

The Laterally-Arrayed Multi-Bandgap (LAMB) structure, with spectrum splitting to multiple optimized cells, is a potentially higher-efficiency and lower-cost alternative to the conventional tandem cell structure for concentrated photovoltaic (CPV) systems. This paper explores a cell-block-level energy harvesting approach for LAMB CPV systems, using a converter with distributed maximum power point tracking (MPPT) capability. A voltage-matching scheme is presented that improves the performance of the converter by interconnecting the cells to provide closely-matched voltages. A Multi-Input Single-Output (MISO) converter topology appropriate for this application is identified, and a prototype MISO converter is built and tested with a PV simulator, a Si cell testbench, and in a systematic demonstration with an optical concentrator and discrete photovoltaic cells. The results demonstrate the potential of a co-packaged LAMB-with-converter CPV architecture for enhanced energy capture under practical conditions.
Metabolomics of prostate cancer (2007)

Biomarkers for predicting whether subjects with elevated PSA should be monitored or have a prostate biopsy would reduce numbers of unnecessary biopsies. Biomarkers predictive of localized versus aggressive prostate tumors would better guide treatment decisions in biopsy-confirmed prostate cancer. Global metabolomics was thus used to discover biomarkers for discriminating between: localized prostate tumors (PCa), metastatic prostate tumors (Met), and benign adjacent prostate tissue (N) by analyzing tissue following prostatectomy (study 1); and prostate cancer from benign prostate conditions by analyzing plasma and spun urine obtained post-digital rectal exam (study 2). Subjects in both studies had elevated PSA and Gleason scores. Number of peaks in prostate, plasma, and urine were 432, 372, and 423, respectively. Comparing PCa/N, Met/N, Met/PCa (study 1), plasma GS major 4+/0, and urine GS major 4+/0, numbers of total peaks changed (q<0.1 study 1, q<0.2 study 2) were: 124, 403, 389, 48, and 200, respectively. Significantly changed peaks were linked to pathways including: urea cycle and metabolism of amino groups, purine metabolism, pyrimidine metabolism, glycine, serine and threonine metabolism, glutamate metabolism, glutathione metabolism, and citrate cycle. Further biological interpretations will be presented. Funded by NCI-EDRN U01CA084986 and NCI-SBIR HHSN261200633002C.
LPS가 처리된 RAW 264.7 대식세포에서 Nrf2/HO-1 경로 조절을 통한 매실 추출물의 NO 생성 억제 효과 (2017)

Objectives : The fruit of Prunus mume Siebold & Zucc. has been used as an alternative medicine and functional food in Korea and Japan for preventive and therapeutic purposes. However, its molecular actions and mechanism on anti-inflammatory activity have not been clearly investigated. The aim of thi...
Supplementary Figure 3 from Pharmacokinetic and Pharmacodynamic Analysis of Circulating Biomarkers of Anti-NRP1, a Novel Antiangiogenesis Agent, in Two Phase I Trials in Patients with Advanced Solid Tumors (2023)

&lt;p&gt;PDF file, 57K, Ratio of plasma PlGF or cNRP1 to baseline for each subject at all time points evaluated (Days 14, 21) from the Phase Ia study.&lt;/p&gt;
Establishing implantation uncertainties for focal brachytherapy with I-125 seeds for the treatment of localized prostate cancer (2015)

This study provides an estimate of 0.5 cm for the margin required for robust coverage of a focal target volume prior to actually implementing a focal treatment protocol.
Supplementary Figure 11 from Sensitive Detection of Minimal Residual Disease in Patients Treated for Early-Stage Breast Cancer (2023)

&lt;p&gt;MRD testing in newly diagnosed, metastatic BC patients. (A) Number of mutations detected for each patient's sample. Each patient's panel was additionally applied to healthy donors as a specificity check. (B) Tumor fraction estimates for each patient's sample over course of treatment, stratified by clinical benefit. (C) Tumor fraction fold change between first two timepoints, stratified by clinical benefit. Confidence intervals were re-calculated using the Delta Method. (D) Tumor fractions for MRD+ samples split by the minimum fingerprint size required to still detect MRD.&lt;/p&gt;
Lumen formation in three‐dimensional cultures of salivary acinar cells (2010)

A novel system supporting acini-like assembly in a 3D culture system was established. Presence of biomarkers and secretion of salivary enzymes confirms functionality in vitro. Future experiments will test the 3D system in an animal model.
Design of a hybrid modular switch (2017)

Network Function Virtualization (NFV) shed new light for the design, deployment, and management of cloud networks. Many network functions such as firewalls, load balancers, and intrusion detection systems can be virtualized by servers. However, network operators often have to sacrifice programmability to achieve high throughput, especially at networks' edge where complex network functions are required. Here, we design, implement and evaluate Hybrid Modular Switch (HyMoS). The hybrid hardware/software switch aims to meet the requirements of modern-day NFV applications by providing high-throughput, highly programmable packet forwarding. HyMoS utilizes P4-compatible Network Interface Cards (NICs), PCI Express interface and CPU to act as line cards, switch fabric, and fabric controller respectively. HyMos turns PCI Express interface into a non-blocking switch fabric with a throughput of hundreds of Gigabits per second. Compared to existing NFV infrastructure, HyMoS offers modularity in hardware and software as well as a higher degree of programmability by supporting a superset of P4 language.
Intersection of Two Planes (2000)

Everyone knows that the intersection of two planes in 3D is a line, and it’s easy to compute the line’s parameters. But, the cookbook formulae for the line are not necessarily the best nor most intuitive way of representing the line. This short note gives the derivation and the formula that I came up with when I was faced with this problem and couldn’t find a solution l liked anywhere. It is also a simple example of how to use Lagrange multipliers.
H9N2 influenza viruses from Bangladesh: Transmission in chicken and New World quail (2018)

The H9N2 influenza viruses that have become established in Bangladeshi live poultry markets possess five gene segments of the highly pathogenic H7N3 avian influenza virus. We assessed the replication, transmission, and disease potential of three H9N2 viruses in chickens and New World quail. Each virus replicated to high titers and transmitted by the airborne route to contacts in both species. Infected chickens showed no disease signs, and the viruses differed in their disease potential in New World quail. New World quail were more susceptible than chickens to H9N2 viruses and shed virus after airborne transmission for 10 days. Consequently, New World quail are a potential threat in the maintenance and spread of influenza virus in live poultry markets.
Compiling machine learning algorithms with SystemML (2013)

Analytics on big data range from passenger volume prediction in transportation to customer satisfaction in automotive diagnostic systems, and from correlation analysis in social media data to log analysis in manufacturing. Expressing and running these analytics for varying data characteristics and at scale is challenging. To address these challenges, SystemML implements a declarative, high-level language using an R-like syntax extended with machine-learning-specific constructs, that is compiled to a MapReduce runtime [2]. The language is rich enough to express a wide class of statistical, predictive modeling and machine learning algorithms (Fig. 1). We chose robust algorithms that scale to large, and potentially sparse data with many features.
Integration of a wet analysis system on a glass chip: determination of Co(ii) as 2-nitroso-1-naphthol chelates by solvent extraction and thermal lens microscopy (2001)

The integration of a wet analysis system on a glass chip was demonstrated and determination of Co(II) was performed using this system. The Co(II) was extracted into m-xylene from aqueous solution as 2-nitroso-1-naphthol chelates, and colorimetric determination of the m-xylene phase was applied by a thermal lens microscope. The integration of the chemical operation procedures shown here leads to a considerable reduction in analyzing time. The time for extraction in the integrated system, 10 min, was about tenfold shorter than a conventional system using a separatory funnel and mechanical shaker. Moreover, troublesome operations such as phase separation necessary for the conventional system could be omitted. The determination of Co(II) in the range 2 x 10(-7)-1 x 10(-8) M, which was estimated to be 0.072-1.44 zmol, was achieved.
Influence of Domain Size on Toughness of Poly(styrene‐block‐butadiene) Star Block Copolymer/Polystyrene Blends (2004)

Abstract Summary: The toughness of poly(styrene‐ block ‐butadiene) star block copolymer/polystyrene (PS) blends have been investigated using the essential‐work‐of‐fracture approach. The blends show a co‐continuous or layer‐like structure of polystyrene‐rich and polybutadiene‐rich domains arising from the used extrusion process. A tough‐to‐brittle transition at a critical domain size of polystyrene‐rich domains of about 50 nm and a maximum in the non‐essential work of fracture at 20–30% PS (co‐continuous morphology) have been found. Non‐essential work of fracture as a function of the mean thickness of polystyrene‐rich domains, demonstrating a tough‐to‐brittle transition at a critical domain thickness about 50 nm. AFM micrograph of a star block copolymer/PS‐blend containing 40% PS. image Non‐essential work of fracture as a function of the mean thickness of polystyrene‐rich domains, demonstrating a tough‐to‐brittle transition at a critical domain thickness about 50 nm. AFM micrograph of a star block copolymer/PS‐blend containing 40% PS.
Attempted Suicide in Bipolar Disorder: Risk Factors in a Cohort of 6086 Patients (2014)

The principal clinical implication of the present study is to pay attention to the risk of suicidal behaviour in bipolar patients with depressive features and more severe or unstable forms of the disorder.
Multiscale models of nuclear waste reprocessing : from the mesoscale to the plant-scale. (2012)

Abstract Not Provided
P107-M A Workflow to Enable Intelligent and Targeted Second-Chance in High-Throughput Mass Spectrometry Experiments. (2007)

In a typical mass spectrometry experiment, the state-of-the-art sequencing algorithms are able to identify only about 10% to 20% of the tandem-MS spectra. Moreover, due to the high dynamic range and complexity of a sample like human plasma, many proteins or peptides do not even lead to a MSn spectra. This list includes the differentially expressed markers in a typical biomarker discovery study, features that follow a particularly interesting trend, time-course studies, etc. While many of such features can be flagged using computational analysis of the MS1 signal, MSn spectra are still required to get an annotation. Using an in-line post-column split with the TriVersa NanoMate (Advion Biosciences, Ithaca, NY) coupled with the highly sensitive Orbitrap, we have built a system where we collect LC fractions in a 96-well plate, which are then available for direct infusion at a later time. This gives the advantage of direct infusion on a sample of much lower complexity, thus providing longer analysis time, which in turn enables us to (1) perform intelligent and targeted isolation and fragmentation, (2) attempt different fragmentation methodologies, such as CAD, ETD, IRMPD, etc., and (3) perform multi-stage MSn. This analysis is fully automated, and thus capable of targeting hundreds of features. As a result, given a feature list (similar to an inclusion list), which can be built using differential analysis software like Sieve, our workflow provides a targeted and iterative re-analysis in a high-throughput fashion to get high-quality tandem spectra, and thus a much higher chance of getting an annotation.
Esculetin Induces Apoptosis Through EGFR/PI3K/Akt Signaling Pathway and Nucleophosmin Relocalization (2015)

Esculetin, a coumarin compound, has anti-proliferative effects on various types of human cancer cells, but its effect on oral squamous cell carcinoma (OSCC) is unknown. In this study, we determined whether esculetin had anti-proliferative effects on two oral squamous cell lines, HN22, and HSC2. We found that esculetin inhibited cell viability by inducing apoptosis, as evinced by apoptotic cell morphologies, nuclear fragmentation, and the multi-caspase/MMP activity. Furthermore, proteomic analysis was used to identify the target-specific proteins involved in esculetin treatment. Intriguingly, apoptotic cell death by esculetin was associated with significant inhibition of the EGFR/PI3K/Akt signaling pathway. We also demonstrated that the expression of nucleophosmin (NPM) markedly decreased after esculetin treatment, and relocalization of NPM from the nucleous to the cytoplasm, together with p65, potentiated apoptotic stimulation. Additionally, our data indicated that NPM expression was markedly higher in OSCC tissues than in normal tissues. Our results collectively indicated that esculetin inhibited the proliferation of OSCC through EGFR-mediated signaling pathways and down-regulation of NPM as well as the perturbation of NPM trafficking from the nucleolus to the cytoplasm resulted in apoptosis.
Language and Library Support for Climate Data Applications (2009)

Ecosystem scientists now have petabytes of data available for analysis; one source of such data is from Earth orbiting satellites. Effective analysis of this data can help us understand how the Earth’s climate is changing, and determine factors that cause these changes, in turn, providing an opportunity for predicting and preventing future ecological problems by managing the ecology and health of our planet. For example, change detection algorithms [1] can be applied to the EVI time-series data to discover the loss of forest cover, and in turn help determine their impact on carbon emission. Performing the necessary analysis on this data is difficult. Although spatio-temporal data sets can be analyzed at various scales, many phenomena of interest
Exploring Reusability of Disposable Face Masks: Effects of Disinfection Methods on Filtration Efficiency, Breathability, and Fluid Resistance (2021)

To curb the spread of the COVID-19 virus, the use of face masks such as disposable surgical masks and N95 respirators is being encouraged and even enforced in some countries. The widespread use of masks has resulted in global shortages and individuals are reusing them. This calls for proper disinfection of the masks while retaining their protective capability. In this study, the killing efficiency of ultraviolet-C (UV-C) irradiation, dry heat, and steam sterilization against bacteria (<i>Staphylococcus aureus</i>), fungi (<i>Candida albicans</i>), and nonpathogenic virus (<i>Salmonella virus P22</i>) is investigated. UV-C irradiation for 10 min in a commercial UV sterilizer effectively disinfects surgical masks. N95 respirators require dry heat at 100 °C for hours while steam treatment works within 5 min. To address the question on safe reuse of the disinfected masks, their bacteria filtration efficiency, particle filtration efficiency, breathability, and fluid resistance are assessed. These performance factors are unaffected after 5 cycles of steam (10 min per cycle) and 10 cycles of dry heat at 100 °C (40 min per cycle) for N95 respirators, and 10 cycles of UV-C irradiation for surgical masks (10 min per side per cycle). These findings provide insights into formulating the standard procedures for reusing masks without compromising their protective ability.
ChemInform Abstract: Electron Paramagnetic Resonance Spectroscopic Investigation of Manganese Doping in ZnL (L: O, S, Se, Te) Nanocrystals (2013)

Abstract Review: 49 refs.
DESIGN AND EVALUATION OF AN IMPROVED FLOW DIVIDER FOR SAMPLING RUNOFF PLOTS (2004)

An improved flow divider was designed to simplify and lower the cost of collecting runoff data from research plots.The system was designed around commercially available and inexpensive 5-gal (19-L) plastic buckets with screw top lids.A precision cut sheet-metal divider crown is fastened to the lid, allowing it to be easily transferred between buckets. Thedivider crown can be configured to handle various flow rates by specifying the number of flow divisions. Laboratoryevaluation of the design indicated that the system divides runoff with accuracies within .5% over most of the flow range andwithin .15% at very low and very high flows. These results are similar to those found for the more traditional flow dividerdesigns. Adding sediment to the inflow at three different flow rates yielded sediment division accuracies within 7%. Five fieldresearch projects have used the divider system with few problems. The average cost of this system is approximately US $500per plot, in comparison to the US $3000 to $5000 it often costs to instrument a plot using standard equipment.
Multilaboratory Comparison of Streptococcus pneumoniae Opsonophagocytic Killing Assays and Their Level of Agreement for the Determination of Functional Antibody Activity in Human Reference Sera (2010)

Antibody-mediated killing of Streptococcus pneumoniae (pneumococcus) by phagocytes is an important mechanism of protection of the human host against pneumococcal infections. Measurement of opsonophagocytic antibodies by use of a standardized opsonophagocytic assay (OPA) is important for the evaluation of candidate vaccines and required for the licensure of new pneumococcal conjugate vaccine formulations. We assessed agreement among six laboratories that used their own optimized OPAs on a panel of 16 human reference sera for 13 pneumococcal serotypes. Consensus titers, estimated using an analysis-of-variance (ANOVA) mixed-effects model, provided a common reference for assessing agreement among these laboratories. Agreement was evaluated in terms of assay accuracy, reproducibility, repeatability, precision, and bias. We also reviewed four acceptance criterion intervals for assessing the comparability of protocols when assaying the same reference sera. The precision, accuracy, and concordance results among laboratories and the consensus titers revealed acceptable agreement. The results of this study indicate that the bioassays evaluated in this study are robust, and the resultant OPA values are reproducible for the determination of functional antibody titers specific to 13 pneumococcal serotypes when performed by laboratories using highly standardized but not identical assays. The statistical methodologies employed in this study may serve as a template for evaluating future multilaboratory studies.
Electrostatic Capture Efficiency Enhancement of Polypropylene Electret Filters with Barium Titanate (2015)

This study reports on the effects of BaTiO3—a high dielectric constant additive—addition on charging and filtration properties of meltblown polypropylene (PP) electret filters. Since electrostatic capture efficiency of electret filters is mainly dependent on electrical forces, surface potential and aerosol filtration properties were analyzed and compared. Due to quasi-permanent nature of electret property, stability of charging and filtration performance was also investigated via following an isothermal charge decay procedure. Addition of BaTiO3 did not alter fiber morphology significantly. Particularly, the stability of electrostatic filtration performance was found to be promising with the addition of BaTiO3. Possible microstructural changes after addition of BaTiO3 were investigated via wide angle X-ray diffraction. Changes in crystal structure of PP upon addition of BaTiO3 did not deteriorate electrostatic properties.Copyright 2015 American Association for Aerosol Research
알츠하이머 치매 환자에서의 인지영역별 기능과 병식과의 연관성 : A Clinical Research Center for Dementia of South Korea Study (2014)

Objective:The aim of this study was to investigate the association between cognitive subdomains and insight into one's cognitive impairment in patients with Alzheimer disease (AD). Methods:We recruited 1,722 patients with AD from the Clinical Research of Dementia of South Korea study and designed a ...
Formation of 1,1-α,α-Glycosidic Bonds By Intramolecular Aglycone Delivery. A Convergent Synthesis of Trehalose (2003)

[reaction: see text] We report a new synthesis of trehalose analogs that involves the use of intramolecular aglycone delivery for stereoselective formation of the 1,1-alpha,alpha-glycosidic bond. The glycosylation reaction afforded the desired isomer exclusively and in good yield.
Characterization of Four Toxins from Buthus Martensi Scorpion Venom, which Act on Apamin‐Sensitive Ca2+‐Activated K+ Channels (1997)

Four peptidyl inhibitors of the small-conductance Ca2+-activated K+ channels (SK(Ca)) have been isolated from the venom of the Chinese scorpion Buthus martensi. These peptides were identified by screening C18 HPLC fractions of the crude venom by means of mass analysis by matrix-assisted-laser-desorption/ionization time-of-flight mass spectrometry, and toxicological tests in mice. Edman degradation analysis of the purified peptides showed sequences of 28-31 amino acids including 6 cysteine residues. Three of the sequences were similar to the P01 peptides from Androctonus scorpions, showing 76% sequence similarity for the most closely related, named BmP01, and 46% for the other two, named BmP02 and BmP03. Like the P01 peptides, these molecules showed a low toxic activity in mice after intracerebroventricular injection, and competed (K0.5 > 1 microM) with iodinated apamin for binding to its receptor site from rat brain, which has been proved to be the SK(Ca) channels. The fourth toxin was structurally related to the P05/leiurotoxin I toxin family, with 90% similarity, and was named BmP05. This toxin exhibited a high toxic activity with lethal effects in mice. Due to its small representation in the venom [less than 0.01% (by mass)], its biological properties have been assessed on the synthetic analogue of BmP05, which was assembled on a solid phase by means of Fmoc methodology. The synthetic peptide was physicochemically identical to the natural peptide, as shown by comparison of their molecular masses and amino acid compositions, and by their coelution after coinjection on capillary electrophoresis. These results confirmed the primary structure of BmP05 including an amidated C-terminus. Similarly to natural BmP05, synthetic BmP05 produced toxic and lethal effects after intracerebroventricular injection in mice (LD50 = 37 ng), and was able to compete with iodinated apamin for binding to its receptor in rat brain (K0.5 = 20 pM).
Topical Doxycycline Can Induce Expression of BDNF in Transduced Retinal Pigment Epithelial Cells Transplanted into the Subretinal Space (2008)

The expression of BDNF can be significantly increased by topical DOX after Tet-BDNF-RPE subretinal transplantation. Better photoreceptor protection against phototoxicity was achieved by DOX eye drops after the cell transplantation.
Effects of Electrical Wave Form on Pore Size of Micro-Arc Oxidized TiO<sub>2</sub> Film (2006)

The surface morphology of commercially pure titanium was investigated with varying electrical waveform. Controlling of electrical pulse width is effective to change pore sizes. Longer electrical pulse width was induced, larger size of pores were generated.
Supplementary Table S1 from Intrinsic Immunogenicity of Small Cell Lung Carcinoma Revealed by Its Cellular Plasticity (2023)

&lt;p&gt;Supplementary Table S1&lt;/p&gt;