gebhart/patrepeval huggingface dataset:
Chimäre antigenspezifische T-Lymphozyten und natürliche Killerzellen für die Krebsimmuntherapie (2016)

Mehr als 20 Jahre nach den ersten Versuchen, die gezeigt haben, dass T-Lymphozyten mittels Gentransfer eines chimären Antigenrezeptors (CAR) künstlich mit einer Spezifität gegen Tumorantigene ausgerüstet werden können, erzielt dieser Ansatz bahnbrechende therapeutische Erfolge bei Patienten mit B-Zell-Leukämien unter Verwendung von Anti-CD19-CAR-T-Zellen. Die langanhaltende klinische Remission in Patienten mit ansonsten überaus schlechter Prognose ist der 2. und 3. Generation chimärer Antigenrezeptoren geschuldet, die nun die für eine Expansion von T-Lymphozyten in vivo wichtige Kostimulation intrinsisch innerhalb des CAR vorhalten. Der große therapeutische Durchbruch in zuvor unheilbaren hämatologischen Erkrankungen hat zu einer Flut von neuen therapeutischen Ansätzen in einer Vielzahl von hämatologischen und soliden Tumoren geführt, bei denen diese neue Zelltherapie nun klinisch erprobt wird. Es bleibt abzuwarten, ob sich die guten klinischen Ergebnisse, die bei akuten lymphatischen Leukämien (B-ALL) erzielt wurden, auch auf andere hämatologische Erkrankungen und insbesondere auch auf solide Tumoren ausweiten lassen. Nichtsdestotrotz stehen für Patienten mit B-Zell-Leukämien, bei denen bisherige Standardtherapien – inklusive einer Stammzelltransplantation – versagt haben, heute neue Therapieoptionen zur Verfügung. Diese effizienten Therapieverfahren sollten möglichst zeitnah auch für Patienten in Deutschland zugängig gemacht werden. Die Einrichtungen für Transfusionsmedizin, Hämatologie und Onkologie sowie die nationalen und internationalen Aufsichtsbehörden sind gefragt, hier konstruktiv und mit Blick auf den klinischen Bedarf – jedoch ebenfalls die Sicherheit – der Patienten eine rasche Verfügbarkeit in Deutschland zu gewährleisten.
Generative self-supervised learning for gate sizing (2022)

Self-supervised learning has shown great promise in leveraging large amounts of unlabeled data to achieve higher accuracy than supervised learning methods in many domains. Generative self-supervised learning can generate new data based on the trained data distribution. In this paper, we evaluate the effectiveness of generative self-supervised learning on combinational gate sizing in VLSI designs. We propose a novel use of Transformers for gate sizing when trained on a large dataset generate from a commercial EDA tool. We demonstrate that our trained model can achieve 93% accuracy, 1440X speedup and fast design convergence when compared to a leading commercial EDA tool.
Changes in the gastric enteric nervous system and muscle: A case report on two patients with diabetic gastroparesis (2008)

We conclude that poor metabolic control is associated with significant pathological changes in the gastric wall that affect all major components including muscle, neurons and ICC. Severe symptoms can occur in the absence of these changes, however and may reflect vagal, central or hormonal influences. Gastroparesis is therefore likely to be a heterogeneous disorder. Careful molecular and pathological analysis may allow more precise phenotypic differentiation and shed insight into the underlying mechanisms as well as identify novel therapeutic targets.
Effects of one year of hemodialysis on weight and blood pressure in 434 patients. (1997)

Excess volume is thought to be the major mechanism leading to hypertension in the hemodialysis population. Blood pressure measurements and volume parameters were obtained in 434 hemodialysis patients in 1994 and compared to their 1993 data. Equal numbers of patients were receiving antihypertensive treatment in both 1993 and 1994. The predialysis mean arterial pressure (pre-MAP) did not significantly change after 1 year of dialysis. The lack of change in blood pressure was evident in those who either lost or maintained body weight. There was no correlation between changes in interdialytic weight and changes in pre-MAP over 1 year. Volume sensitivity (described as the percentage decrease in blood pressure immediately after dialysis) was not different in 1993 from 1994. We conclude that irrespective of weight changes, the average hemodialysis patient does not show a significant change in blood pressure (BP) after 1 year of dialysis. This lack of improvement was evident regardless of age, sex, race, dialysis duration, or etiology of end-stage renal disease.
Synthesis and characterization of aromatic and brominated aromatic polycarbonates by two‐phase phase‐transfer‐catalyzed polycondensation of bisphenols with trichloromethyl chloroformate (1997)

Aromatic and brominated aromatic homopolycarbonates were synthesized by the two-phase phase-transfer-catalyzed polycondensation of bisphenols with trichloromethyl chloroformate at 25°C. The infrared spectra, inherent viscosity, x-ray diffraction, solubility, contact angle, differential scanning calorimetry, thermogravimetric analysis, and limiting oxygen index (LOI) of all polycarbonates were measured. Polycarbonates of moderate or large molar mass with inherent viscosities up to 0.77 dL/g were obtained in high yields with tetrabutylammonium bromide (TBAB) as a catalyst, sodium hydroxide as a base, and 1,2-dichloroethane as solvent. The brominated polycarbonates have good flame retardency, as indicated by LOI values. The x-ray diffraction diagram showed that all polycarbonates were semicrystalline. The polycarbonate (PC-2) based on bisphenol S has greater crystallinity than the others because of the sulfonyl group, which has a small van der Waals radius. The incorporation of the bromine atoms (PC-4-PC-6) on the ring decreased the crystallinity. Almost all polymers were soluble in DMF, pyridine, and phenol, but insoluble in acetone and m-cresol. Solubility increased remarkably with bromine substitution. The contact angles of polycarbonates (PC-1-PC-3) lie in the of range 82 to 97 degrees greater than that of brominated polycarbonates (PC-4-PC-6). The wettability of the homopolycarbonate based on bisphenol S is greater than that of polycarbonates derived from bisphenol A and bisphenol AF. Tg of polycarbonates lies in the range 141–206°C, although Tg of polycarbonate based on bisphenol S was not detected. Tg of brominated polycarbonates was remarkably greater than that of unbrominated polycarbonates. These polymers obtained from aromatic bisphenols lost no mass below 341°C, but 10% loss of mass was recorded above 396°C in nitrogen. © 1997 John Wiley & Sons, Inc.
Sulphite efflux pumps in Aspergillus fumigatus and dermatophytes (2007)

Dermatophytes and other filamentous fungi excrete sulphite as a reducing agent during keratin degradation. In the presence of sulphite, cystine in keratin is directly cleaved to cysteine and S-sulphocysteine, and thereby, reduced proteins become accessible to hydrolysis by a variety of secreted endo- and exoproteases. A gene encoding a sulphite transporter in Aspergillus fumigatus (AfuSSU1), and orthologues in the dermatophytes Trichophyton rubrum and Arthroderma benhamiae (TruSSU1 and AbeSSU1, respectively), were identified by functional expression in Saccharomyces cerevisiae. Like the S. cerevisiae sulphite efflux pump Ssu1p, AfuSsu1p, TruSsu1p and AbeSsu1p belong to the tellurite-resistance/dicarboxylate transporter (TDT) family which includes the Escherichia coli tellurite transporter TehAp and the Schizosaccharomyces pombe malate transporter Mae1p. Seven genes in the A. fumigatus genome encode transporters of the TDT family. However, gene disruption of AfuSSU1 and of the two more closely related paralogues revealed that only AfuSSU1 encodes a sulphite efflux pump. TruSsulp and AbeSsulp are believed to be the first members of the TDT family identified in dermatophytes. The relatively high expression of TruSSU1 and AbeSSU1 in dermatophytes compared to that of AfuSSU1 in A. fumigatus likely reflects a property of dermatophytes which renders these fungi pathogenic. Sulphite transporters could be a new target for antifungal drugs in dermatology, since proteolytic digestion of hard keratin would not be possible without prior reduction of disulphide bridges.
Inhibition of Purified Recombinant Reverse Transcriptase from Wild‐Type and Zidovudine‐Resistant Clinical Isolates of Human Immunodeficiency Virus Type 1 by Zidovudine, Stavudine, and Lamivudine Triphosphates (2001)

Cross-resistance between zidovudine, stavudine, and lamivudine was studied, using purified recombinant reverse transcriptase from a zidovudine-susceptible and -resistant pair of clinical isolates of human immunodeficiency virus type 1. The zidovudine-resistant isolate exhibited low-level cross-resistance to both stavudine and lamivudine in drug susceptibility assays. Enzyme from the resistant isolate demonstrated reduced inhibition by zidovudine triphosphate and stavudine triphosphate and, to a lesser extent, lamivudine triphosphate. These findings provide additional evidence at the viral and enzyme level for cross-resistance between zidovudine and stavudine, and they suggest a possible effect of zidovudine resistance on susceptibility to lamivudine.
Evaluation of Thermal Comfort for Novel Aircraft Cabin Ventilation Concepts (2020)

Flexible cabin layout, high demands on thermal comfort and energy efficiency as well as industrial modular design are the main challenges for aircraft engineers when addressing the ventilation of the aircraft cabin. Nowadays, mixing ventilation is installed in all commercial aircraft, guaranteeing a high degree of mixing and therefore a robust and stable ventilation concept for the cabin [1]. However, complex and weight-intensive ducts are required. In addition, the system provides only limited heat removal efficiency and high velocities are prone to draft on single seats [2]. Addressing these challenges, we are investigating novel ventilation concepts within the ADVENT project - Advanced ventilation techniques for modern long-range passenger aircraft to promote future energy management systems.
A case study of Venus and a declarative basis for rule modules (1996)

Article A case study of Venus and a declarative basis for rule modules Share on Authors: Lane B. Warshaw Department of Computer Sciences and Applied Research Laboratories, The University of Texas at Austin Department of Computer Sciences and Applied Research Laboratories, The University of Texas at AustinView Profile , Daniel P. Miranker Department of Computer Sciences and Applied Research Laboratories, The University of Texas at Austin Department of Computer Sciences and Applied Research Laboratories, The University of Texas at AustinView Profile Authors Info & Claims CIKM '96: Proceedings of the fifth international conference on Information and knowledge managementNovember 1996 Pages 317–325https://doi.org/10.1145/238355.238569Published:12 November 1996 4citation284DownloadsMetricsTotal Citations4Total Downloads284Last 12 Months0Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Wurtzite GaN surface structures studied by scanning tunneling microscopy and reflection high energy electron diffraction (1998)

We report studies of the surface reconstructions for both the Ga-face and the N-face of wurtzite GaN films grown using molecular beam epitaxy. N-face reconstructions are primarily adatom-on-adlayer structures which can be formed by room temperature submonolayer Ga deposition. These structures undergo reversible order–disorder phase transitions to 1×1 in the temperature range of 200–300 °C. Ga-face reconstructions, on the other hand, require annealing to high temperatures (600–700 °C) in order to form, and in most cases they are stable at those temperatures. The film polarity is found to be determined by the initial nucleation stage of the film growth.
Inflammatory and Comorbid Features of Patients with Severe Asthma and Frequent Exacerbations (2016)

EPA may be a distinct susceptibility phenotype with implications for the targeting of exacerbation prevention strategies. Clinical trial registered with www.clinicaltrials.gov (NCT 01760915).
A model checking framework for linear time invariant switching systems using structural systems analysis (2013)

This paper introduces the concept of structural hybrid systems to address, as a particular case, the model checking problem of switching (possible large scale) linear time invariant systems. Within the proposed setup, we provide necessary conditions to ensure properties such as controllability, at each time. We show that such model checking controllability properties can be implemented using efficient algorithms (with polynomial complexity). An example, based on the IEEE 5-bus power system, is presented which illustrates our model checking and design methodologies.
Integrated active contours for texture segmentation (2006)

We address the issue of textured image segmentation in the context of the Gabor feature space of images. Gabor filters tuned to a set of orientations, scales and frequencies are applied to the images to create the Gabor feature space. A two-dimensional Riemannian manifold of local features is extracted via the Beltrami framework. The metric of this surface provides a good indicator of texture changes and is used, therefore, in a Beltrami-based diffusion mechanism and in a geodesic active contours algorithm for texture segmentation. The performance of the proposed algorithm is compared with that of the edgeless active contours algorithm applied for texture segmentation. Moreover, an integrated approach, extending the geodesic and edgeless active contours approaches to texture segmentation, is presented. We show that combining boundary and region information yields more robust and accurate texture segmentation results.
Abstract 2067: Attacking prostate cancer with a prodrug-doped cellular Trojan horse (2016)

Abstract Prostate cancer is the second leading cause of cancer-related deaths in American men. Despite considerable advances in prostate cancer research, there is a major need for a systemic delivery platform that efficiently targets anti-cancer drugs to sites of disseminated prostate cancer while minimizing host toxicity. Human mesenchymal stem cells (MSCs) are excellent candidates for cell-based drug delivery since they display tropism towards cancer sites and clinical studies have demonstrated that hundreds of millions of allogeneic human MSCs can be safely administered intravenously without adverse effects in a variety of pathological settings. Furthermore, we have previously documented that MSCs can be detected in radical prostatectomy tissue from men with prostate cancer. In this proof-of-concept study, human MSCs were loaded with poly(lactic-co-glycolic acid) (PLGA) microparticles (MPs) encapsulating the macromolecule G114, a thapsigargin-based prostate specific antigen (PSA)-activated prodrug. G114-loaded MPs were successfully internalized by MSCs without impacting MSC viability, followed by sustained release of G114 as an intact prodrug from loaded cells. Moreover, G114 released from G114 MP-loaded MSCs is selectively toxic to the PSA-secreting prostate cancer cell line, LNCaP. Finally, G114 MP-loaded MSCs inhibited tumor growth when co-inoculated with CWR22 prostate cancer xenografts, suggesting that cell-based delivery of G114 does not compromise potency of the prodrug in vitro or in vivo. We envision that this MSC-based platform may be developed into an effective, systemic ‘Trojan Horse’ therapy for the targeted delivery of therapeutic agents to sites of metastatic prostate cancer. Citation Format: Nathaniel Brennen, Oren Levy, Edward Han, David Marc Rosen, Juliet Musabeyezu, Helia Safaee, Sudhir Ranganath, Jessica Ngai, Martina Heinelt, Sandrine Billett, Neil Bhowmick, Samuel Denmeade, Jeffrey Karp, John Isaacs. Attacking prostate cancer with a prodrug-doped cellular Trojan horse. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 2067.
ChemInform Abstract: Studies Directed to the Synthesis of the Antifungal Antibiotic Aleurodiscal. Enantioselective Construction of an Advanced β‐D‐Xyloside Congener. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Messergebnisse und Simulationen der Lichtreflexion an Tropfen bei der Messung mit Fasersensoren (Results of Measurement and Simulation of the Light Reflection from Drops on Fibre Sensors) (2006)

Diese Arbeit stellt eine Messtechnik vor zur Charakterisierung von Mehrphasenströmungen mit einem optischen Fasersensor. Gemessen wird der Verlauf des Tropfenaufpralls auf dem Sensorende. Der komplexe Signalverlauf wird anhand zweier Simulationen erklärt. Die experimentellen Ergebnisse zeigen eine gute Übereinstimmung mit den Berechnungen. Ein Modell der Totalreflexion am Wasserrest, der auf dem Faserende verbleibt, erklärt eine bestimmte Signaleigenschaft.
Breadth First Search on Cost-efficient Multi-GPU Systems (2016)

A parallel Breadth First Search (BFS) algorithm is proposed for cost-efficient multi-GPU systems without enough memory amount or communication performance. By using an improved data structure for the duplication elimination of local nodes, both required memory amount and processing time are reduced. By using Unified Virtual Addressing, time for communication can be hidden with the computation. The proposed algorithm is implemented on two costefficient multi-GPU systems: Express multi-GPU system which has a full of flexibility but the communication latency between GPU and host is limited, and a high-end gaming machine whose memory is limited. Both systems achieve good strong scaling with the proposed methods. On Express multi-GPU system, the communication overhead was almost completely hidden, and the aggregate communication throughput reached 4.77 GB/sec (38.16 Gbps), almost theoretical maximum.
Spectrally efficient L-C band EDFA having a continuous inter-band channel region using sampled FBGs (2000)

Summary form only given.One of the most promising techniques for expanding the bandwidth of WDM systems is the L-C band silica-based EDFA in which the signals are split and passed through a parallel configuration, including a conventional EDFA (C-band) for signals ranging from /spl sim/1530 to /spl sim/1565 nm, and an L-band EDFA for signals ranging from /spl sim/1565 to /spl sim/1600 nm. We report a method and demonstration for a spectrally-efficient L-C band EDFA that utilizes the entire wavelength range covering the complete set of L and C bands, by using sampled fiber Bragg grating (FBG) having reflection resonances throughout the L and C bands to efficiently separate the two bands.
Perturbation-Based Frequency Domain Linear and Nonlinear Noise Estimation (2021)

In this paper, a new method for the separation of noise categories based on Four-Wave Mixing is presented. The theoretical analysis is grounded in the Gaussian Noise model and verified by split step simulations. The noise categories react differently to the introduced perturbations, by performing a set of perturbations the behaviour of the different categories can be separated by means of a least-square fitting. Given ASE is independent of the induced perturbations, it is possible to separate noise contributions. The analysis includes constant and variable power perturbations. The estimation of the noise categories is discussed from two points of view: NSR evolution post-DSP processing, and over the power spectral density in a notched region. The NSR estimation can only be performed at reception, whereas the power spectral density approach can be performed along the optical link if a high resolution Optical Spectrum Analyzer is available. Additionally, we perform a simple experimental verification considering of two WaveLogic 3 transceivers for the NSR, successfully estimating the nonlinear noise contributions.
Leaching characteristics of fly ash from municipal solid waste incineration. (2009)

The leaching characteristics of fly ash from municipal solid waste incineration(MSWI) in a flow-through system were studied using column tests.The results from the leaching tests showed that: The pH of the extract increased at the beginning of the experiments and then decreased,and remained in alkaline condition(pH=9.66) until the end of the experiments;The leaching process of main cations(Na~+,K~+,Ca~(2+)) and anions(Cl~-,SO_4~(2-)) in the fly ash mostly happened at the beginning of the experiments(96 days),resulting in very high salinity in earlier lixivium;The leaching concentrations of four heavy metals(Cr,Pb,Cu and Cd) in the column leaching tests were much lower than those of the batch tests,and they were relatively high at the beginning of the experiment.Although the leaching concentrations of the heavy metals obviously decreased when the leaching time was greater than 120 days,the comparative heavy metals could be exuded continuously.
Mechanism‐Guided Improvements to the Single Molecule Oxidation of Carbon Nanotube Sidewalls (2008)

Real-time monitoring of carbon nanotube conductance during electrochemical and chemical etching reveals the electronic signatures of individual bond alteration events on the nanotube sidewall. Tracking the conductance of multiple single-molecule experiments through different synthetic protocols supports putative mechanisms for sidewall derivatization. Insights gained from these mechanistic observations imply the formation of sidewall carboxylates, which are useful as handles for bioconjugation. We describe an electronic state required for efficacious chemical treatment. Such real-time monitoring can improve carboxylate yields to 45 % or more. The experiments illustrate the power of molecular nanocircuits to uncover and direct the mechanisms of chemical reactions.
A dual mode IEEE multiplier (2002)

We present an IEEE floating-point multiplier capable of performing either a double-precision multiplication or a single-precision multiplication. In single-precision the latency is two clock cycles and in double-precision the latency is three clock cycles, where each pipeline stage contains roughly fifteen logic levels. A single-precision multiplication can be followed immediately by another multiplication of either single or double-precision, A double-precision multiplication requires one stall cycle, namely, two cycles after issuing a double-precision multiplication, a new multiplication of either precision can be issued. Therefore, the throughput in single-precision is one multiplication per clock cycle, and the throughput in double-precision is one multiplication per two clock cycles. Hardware cost is reduced by using only a half-sized multiplication array and by sharing the rounding circuitry for both precisions.
Phase-shifted masks for logic circuitry: process latitude versus integration (1993)

Resolution enhanced lithography can be uniquely challenged by high-performance logic derivatives of advanced DRAM technologies.
Upper Voltage and Temperature Dependencies for an All-Solid-State In/LiCoO[sub 2] Cell Using Sulfide Glass Electrolyte (2008)

In this study, all-solid-state cells were assembled using sulfide glass electrolytes. The cells showed high initial charge and discharge capacities of 194 and 169 mAh/g, with 87% efficiency at a fixed current density, 9.5 mA/g, between 2.0 and 4.1 V. The average discharge voltage was low, 3.22 V, but the energy density was 542 mWh/g: higher than the 462 mWh/g of liquid cells. An cell was discharged at (39 mAh/g at 2.4 mA/g) from 3.9 to 1.5 V. Although the suppression of capacity fading is required, its attractive electrochemical properties resemble lithium-ion batteries.