gebhart/patrepeval huggingface dataset:
Memory controllers for high-performance and real-time MPSoCs (2011)

Designing memory controllers for complex real-time and high-performance multi-processor systems-on-chip is challenging, since sufficient capacity and (real-time) performance must be provided in a reliable manner at low cost and with low power consumption. This special session contains four presentations that describe these challenges and proposed solutions for DRAM and flash memory controllers, respectively.
Human Correlates of Provocative Questions in Pancreatic Pathology (2012)

Studies of cell lines and of animal models of pancreatic cancer have raised a number of provocative questions about the nature and origins of human pancreatic cancer and have provided several leads into exciting new approaches for the treatment of this deadly cancer. In addition, clinicians with little or no contact with human pathology have challenged the way that pancreatic pathology is practiced, suggesting that "genetic signals" may be more accurate than today's multimodal approach to diagnoses. In this review, we consider 8 provocative issues in pancreas pathology, with an emphasis on "the evidence derived from man."
A General and Efficient Copper Catalyst for the Amidation of Aryl Halides. (2002)

Abstract For Abstract see ChemInform Abstract in Full Text.
How Excitation Conditions Alter the Afterglow Characteristics of CsI:Tl,Sm Microcolumnar Films (2019)

Combining high light output with the microcolumnar structure, the CsI:Tl films significantly reduce the need for painful tradeoff between thickness (hence, stopping power) and spatial resolution. But both films and monocrystals share two important deficiencies that hinder their use in many high-speed imaging and computed tomography applications: a persistent afterglow and hysteresis. These properties receive the primary attention of this investigation. In our earlier work, we reported that codoping with Sm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2+</sup> brings about a significant reduction in the afterglow of CsI:Tl. Here, focusing on the microcolumnar films, we examine this afterglow-suppressive effect over a wide range of exposure times, from milliseconds to seconds, and at temperatures between 0 °C and 60 °C. Our measurements reveal well-defined dependences on both parameters. At room temperature (20 °C), defined as the normal operating condition, a 10-ms X-ray pulse leaves an afterglow from the standard (Sm-free) CsI:Tl of about 1% at 2 ms after the end of the pulse, changing little as a function of pulselength. Doping with Sm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2+</sup> , however, reduces that afterglow by at least an order of magnitude, although somewhat less so after longer (100 and 1000 ms) pulses. When we change the temperature, however, we find markedly different behavior. Here, we find that a temperature increase of only 60°, without changing the pulselength, cuts the afterglow of standard CsI:Tl films by a factor of 20. However, films of codoped CsI:Tl,Sm, whose afterglow has already been suppressed by the presence of Sm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2+</sup> , show much less change as a function of either temperature or pulse duration. It is the presence of Sm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2+</sup> that makes the biggest difference. As for hysteresis, we again see an improvement, with the performance of the codoped CsI:Tl,Sm films bettering that of the standard (Sm-free) films. After an exposure of 300 mR, the change in light output falls to within 1% of the original after 1 min, whereas standard CsI:Tl films require 30 min to reach the same level.
The Effect of Microwave Treatment On the Mn3+ Concentration of Spinel Cathode Material Studied By XPS, XRD and Electrochemical Methods (2013)

Abstract not Available.
The Role of Extracellular HSP70 in the Function of Tumor-Associated Immune Cells (2021)

Extracellular vesicles released by tumor cells (T-EVs) are known to contain danger-associated molecular patterns (DAMPs), which are released in response to cellular stress to alert the immune system to the dangerous cell. Part of this defense mechanism is the heat shock protein 70 (HSP70), and HSP70-positive T-EVs are known to trigger anti-tumor immune responses. Moreover, extracellular HSP70 acts as an immunogen that contributes to the cross-presentation of major histocompatibility complex (MHC) class I molecules. However, the release of DAMPs, including HSP70, may also induce chronic inflammation or suppress immune cell activity, promoting tumor growth. Here, we summarize the current knowledge on soluble, membrane-bound, and EV-associated HSP70 regarding their functions in regulating tumor-associated immune cells in the tumor microenvironment. The molecular mechanisms involved in the translocation of HSP70 to the plasma membrane of tumor cells and its release via exosomes or soluble proteins are summarized. Furthermore, perspectives for immunotherapies aimed to target HSP70 and its receptors for cancer treatment are discussed and presented.
Special Interest Messaging: A Comparison of IGM Approaches (2007)

Hundreds of technical, special interest Internet weblogs are already generating thousands of niche articles worldwide, and many institutions are starting to create internal blogs for team collaboration. As this style of communication becomes more pervasive in the lives of employees and researchers, the difficulty of finding relevant information only grows with the number of authors and articles. To reduce the load, we propose using implicit group messaging (IGM) to automatically deliver relevant content to readers grouped by shared characteristics or interests. In this paper, we outline a context-aware application suited to special interest messaging and describe three alternative delivery models including our peer-to-peer (P2P) design called SPICE and a broker-based design. We investigate the advantages and disadvantages of each approach through detailed simulations driven by realistic data and actual national/global network topologies. We find that although a broker-based design is generally the most network efficient and lowest latency, a structured P2P system can offer exceptionally low and fair loading across peers and network links without relying on specialized broker nodes.
Activation of STAT transcription factors by herpesvirus Saimiri Tip-484 requires p56lck (1997)

Signal transducers and activators of transcription (STATs) relay signals from activated cell surface receptors directly to the nucleus. Previously, a protein required for T-cell transformation by the DNA tumor virus herpesvirus saimiri (HVS) and designated tyrosine kinase interacting protein (Tip-484) was shown to interact with and dramatically upregulate the activity of p56lck. p56lck is a nonreceptor tyrosine kinase that is essential for signaling by the T-cell receptor and also interacts with the CD4, CD8, and interleukin-2 receptors. The present data show activation of STAT1 and -3 by Tip-484. STAT1 and -3 were also found to complex with glutathione S-transferase-Tip-484 only in the presence of p56lck, and STAT3 was shown to be phosphorylated by the Tip-484-p56lck multiprotein complex in vitro. Infection of T cells with HVS or expression of recombinant Tip-484 significantly increased the DNA-binding activity of the STAT1 and STAT3 transcription factors in nuclear extracts and also increased the phosphorylation of STAT3 in vivo. This is the first report of STAT activation by a DNA tumor virus protein. Moreover, these studies demonstrate that p56lck is required for STAT activation by Tip-484.
Characterization of a New Antifungal Chitin-Binding Peptide from Sugar Beet Leaves (1997)

The intercellular washing fluid (IWF) from leaves of sugar beet (Beta vulgaris L.) contains a number of proteins exhibiting in vitro antifungal activity against the devastating leaf pathogen Cercospora beticola (Sacc.). Among these, a potent antifungal peptide, designated IWF4, was identified. The 30-amino-acid residue sequence of IWF4 is rich in cysteines (6) and glycines (7) and has a highly basic isoelectric point. IWF4 shows homology to the chitin-binding (hevein) domain of chitin-binding proteins, e.g. class I and IV chitinases. Accordingly, IWF4 has a strong affinity to chitin. Notably, it binds chitin more strongly than the chitin-binding chitinases. A full-length IWF4 cDNA clone was obtained that codes for a preproprotein of 76 amino acids containing an N-terminal putative signal peptide of 21 residues, followed by the mature IWF4 peptide of 30 residues, and an acidic C-terminal extension of 25 residues. IWF4 mRNA is expressed in the aerial parts of the plant only, with a constitutive expression in young and mature leaves and in young flowers. No induced expression of IWF4 protein or mRNA was detected during infection with C. beticola or after treatment with 2,6-dichloroisonicotinic acid, a well-known inducer of resistance in plants.
32A9, a novel human antibody for designing an immunotoxin and CAR-T cells against glypican-3 in hepatocellular carcinoma (2020)

Our study provides a rationale for 32A9 as a promising GPC3-specific antibody candidate for HCC immunotherapy.
Continuous Formal Verification of Amazon s2n (2018)

We describe formal verification of s2n, the open source TLS implementation used in numerous Amazon services. A key aspect of this proof infrastructure is continuous checking, to ensure that properties remain proven during the lifetime of the software. At each change to the code, proofs are automatically re-established with little to no interaction from the developers. We describe the proof itself and the technical decisions that enabled integration into development.
Reverse Bohr effect on the oxygen-binding affinity of heme embedded in a bilayer of liposome as a hemoglobin model: pH-induced oxygen uptake and evolution by aqueous synthetic lipid-heme solution (1987)

The oxygen-binding affinity (p½; oxygen pressure at 50% binding for the heme) of a heme derivative embedded in a bilayer of natural phospholipid liposomes was influenced by the solution pH: the p½ value of the liposome–lipid-heme increased with pH {Bohr coefficient, r=d[log(p½)]d(pH)=+0.09 to +0.32}, which is the reverse of the Bohr effect for hemoglobin. This pH dependence was affected by the composition of the liposome–lipid-heme. Its mechanism is discussed in relation to the surrounding lipid bilayer structure and protonation equilibrium of the imidazole ligand. pH-induced oxygen-uptake and -evolution was observed, in a process which was sensitive to ±1 unit of pH change at pH 7.
Two-Photon Photochromism of an Organic Material for Holographic Recording (2002)

We report the two-photon-induced photoisomerization of 3-[1-(1,2-dimethyl-1H-indol-3-yl)-etliylidene]-4-isopropylidene-dihydrofuran-2,5-dione (1), a photochromic compound with lambda(max) = 385 nm, using 775-nm femtosecond pulsed laser irradiation. The resulting photoisomer had lambda(max), = 582 nm. The kinetic rate constant for the two-photon-induced electrocyclic isomerization reaction was measured at two different intensities (two different powers), showing a quadratic dependence with respect to the pump intensity. Results of pump-probe solution phase experiments and guest/host polymer thin film interferometric imaging studies are reported. A two-photon absorption molecular cross section sigma2 = 10.3 x 10(-48) cm(4) (.)s/photon was measured using Z-scan, further supporting a two-photon-induced isomerization process. Two-photon-induced interferometric recording in a fulgide-containing polymer film was demonstrated.
Developing controllable anisotropic wet etching to achieve silicon nanorods, nanopencils and nanocones for efficient photon trapping (2013)

Controllable hierarchy of highly regular, single-crystalline nanorod, nanopencil and nanocone arrays with tunable geometry and etch anisotropy has been achieved over large areas (>1.5 cm × 1.5 cm) by using an [AgNO3 + HF + HNO3/H2O2] etching system. The etching mechanism has been elucidated to originate from the site-selective deposition of Ag nanoclusters. Different etch anisotropies and aspect ratios can be accomplished by modulating the relative concentration in the [AgNO3 + HF + HNO3/H2O2] etching system. Minimized optical reflectance is also demonstrated with the fabricated nano-arrays. Overall, this work highlights the technological potency of utilizing a simple wet-chemistry-only fabrication scheme, instead of reactive dry etching, to attain three-dimensional Si nanostructures with different geometrical morphologies for applications requiring large-scale, low-cost and efficient photon trapping (e.g. photovoltaics).
Effect of Adding Different Concentrations of Cowpea Vigna unguiculata (L.) on Physicochemical and Sensory Properties of Chicken Mortadella (2022)

Four chicken mortadella were prepared: C (control), M1, M2 and M3 by addition of 10%, 15%, and 20% of minced cowpea, respectively). The effect of adding minced cowpea on the physical, chemical, microbial, and sensory evaluation of mortadella had been studied. Results revealed that there were significant differences in fat, carbohydrates, and ash percentages in the mortadella. The fat percentage was gradually decreased from 15.13 % in the control group to 11.03 % in M3. Carbohydrate and ash were increased from 3.94, 2.53 % in the control group to 7.14, and 2.76 % in M3 respectively according to the increase of cowpea in the mortadella. Protein and moisture were increased with no significant difference in all mortadella examined. Water holding capacity was increased significantly by adding minced cowpea. Microbial load test revealed that there was an obvious decrease in total bacterial count and Escherichia coli with an increase of cowpea in the mortadella. For sensory evaluation there were significant differences in some characteristics between control and other groups, colour, flavour, and taste decreased according to the increase of cowpea in the mortadella formulations, the decrease was high in the M3 group and low in M1 and M2 groups with some similarity to the control group. The texture was improved by adding more minced cowpea to the mortadella particularly in the M3 group. Accordingly, the effect of these quality properties was reflected in the degree of general acceptance of the mortadella formulations.
Heparin and Low Molecular Weight Heparin in Thrombosis, Cancer, and Inflammatory Diseases (2004)

Despite the research and development efforts in newer anticoagulants, unfractionated heparin (UFH) and low molecular weight heparin (LMWH) will continue to play a pivotal role in the management of thrombotic disorders. Although bleeding and heparin-induced thrombocytopenia (HIT) represent major side effects of this drug, it has remained the anticoagulant of choice for the prophylaxis and treatment of arterial and venous thrombotic disorders, surgical anticoagulation, and interventional usage. It is the understanding of the structure of heparin that led to the development of LMWHs, synthetic hepari-nomimetics, antithrombin (AT), and anti-Xa agents.
236: Carbonic Anhydrase IX (CAIX) in Bladder Cancer: A Diagnostic, Prognostic and Therapeutic Molecular Marker (2007)

You have accessJournal of UrologyPodium 7, Sunday, May 20, 2007, 8:00 - 10:00 am1 Apr 2007236: Carbonic Anhydrase IX (CAIX) in Bladder Cancer: A Diagnostic, Prognostic and Therapeutic Molecular Marker Tobias Klatte, David B. Seligson, John T. Leppert, Kelly Kawaoka, Jian Yu Rao, Arie S. Belldegrun, and Allan J. Pantuck Tobias KlatteTobias Klatte More articles by this author , David B. SeligsonDavid B. Seligson More articles by this author , John T. LeppertJohn T. Leppert More articles by this author , Kelly KawaokaKelly Kawaoka More articles by this author , Jian Yu RaoJian Yu Rao More articles by this author , Arie S. BelldegrunArie S. Belldegrun More articles by this author , and Allan J. PantuckAllan J. Pantuck More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)30501-9AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "236: Carbonic Anhydrase IX (CAIX) in Bladder Cancer: A Diagnostic, Prognostic and Therapeutic Molecular Marker." The Journal of Urology, 177(4S), p. 79 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 177Issue 4SApril 2007Page: 79 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Tobias Klatte More articles by this author David B. Seligson More articles by this author John T. Leppert More articles by this author Kelly Kawaoka More articles by this author Jian Yu Rao More articles by this author Arie S. Belldegrun More articles by this author Allan J. Pantuck More articles by this author Expand All Advertisement PDF DownloadLoading ...
Human Gyrovirus DNA in Human Blood, Italy (2012)

Human gyrovirus (HGyV) is a recent addition to the list of agents found in humans. Prevalence, biologic properties, and clinical associations of this novel virus are still incompletely understood. We used qualitative PCRs to detect HGyV in blood samples of 301 persons from Italy. HGyV genome was detected in 3 of 100 solid organ transplant recipients and in 1 HIV-infected person. The virus was not detected in plasma samples from healthy persons. Furthermore, during observation, persons for whom longitudinal plasma samples were obtained had transient and scattered presence of circulating HGyV. Sequencing of a 138-bp fragment showed nucleotide identity among all the HGyV isolates. These results show that HGyV can be present in the blood of infected persons. Additional studies are needed to investigate possible clinical implications.
Supplementary Table 1 from A Cross-Species Analysis in Pancreatic Neuroendocrine Tumors Reveals Molecular Subtypes with Distinctive Clinical, Metastatic, Developmental, and Metabolic Characteristics (2023)

&lt;p&gt;Supplementary Table 1 contains underlying data from microRNA and mRNA transcriptome profiling of human and mouse PanNET samples associated with the main and supplementary figures and can be found in different worksheets.&lt;/p&gt;
Spiral Tunneling Cracks Induced by Environmental Stress Cracking in LaRC™-TPI Adhesives (1994)

Abstract Some currently-available formulations of LaRC™-TPI, a thermoplastic polyimide originally developed at NASA-Langley, were found to be highly susceptible to environmental stress cracking when exposed to solvents such as acetone, toluene, diglyme and methyl ethyl ketone. The combination of stress and solvent led to rapid cracking in films and adhesive layers of this material system. Residual cool-down stresses induced when the LaRC-TPI is used as an adhesive or coating led, in the presence of a solvent, to dense “mud crack” patterns which relieve a portion of the stored energy. Because these through-the-thickness cracks are not able to relieve the stored energy in the vicinity of the adherends, additional fractures in the form of curious spiral tunnel cracks initiated and grew inward within each adhesive fragment. Micrographs of the spiral fractures are given, along with a qualitative explanation for the failure process as observed in adhesives and coatings.
Dispersion Compensation in a 3 μm Wavelength OPCPA System by Shaping the 1.5 μm Signal Input (2022)

We report on phase and intensity pulse shaping of the 1.5-μm signal beam of a 3-μm wavelength OPCPA system. This shaper and associated algorithms enable in-situ optimization of nonlinear processes driven at mid-IR wavelengths.
Both Langerhans cells and interstitial DC cross‐present melanoma antigens and efficiently activate antigen‐specific CTL (2007)

Dendritic cells (DC) have a unique capacity to present external antigens to CD8(+) T cells, i.e. cross-presentation. However, it is not fully established whether the ability to cross-presentation is restricted to a unique subset of DC in humans. Here, we show that two major myeloid DC subsets, i.e. Langerhans cells (LC) and interstitial DC (Int-DC), have the ability to cross-present antigens to CD8(+) T cells in vitro. LC and Int-DC were obtained from DC generated by culturing human CD34(+)-hematopoietic progenitor cells with GM-CSF, FLT3-L, and TNF-alpha (CD34-DC). Both DC subsets were able to capture necrotic/apoptotic allogeneic melanoma cells and present antigens to CD8(+) T cells, resulting in efficient priming of naive CD8(+) T cells into CTL capable of killing melanoma cells. Strikingly, a single stimulation with either subset (LC or Int-DC) or total CD34-DC loaded with necrotic/apoptotic melanoma cells was sufficient to activate melanoma-specific memory CD8(+) T cells obtained from patients with metastatic melanoma to become effective CTL. Thus, this study provides the rationale to use CD34-DC loaded with necrotic/apoptotic allogeneic melanoma cells in a clinical trial.
Failure Isolation in Ring Oscillator Circuit and Defect Detection in CMOS Technology Research (2019)

Ring oscillators (ROs) are used for yield learning during the research phase of a CMOS technology generation. Based on electrical data and binning methods, we improve detection and classification fault methodologies and form a yield detractor pareto. Inline defect monitoring can help to estimate RO yield and is essential in CMOS technology research.
Temperature dependence of switching performance in IGBT circuits and its compact modeling (2011)

We have developed the compact IGBT model HiSIM-IGBT, based on a complete solution for the potential distribution, which connects the surface-potential of the MOS-FET part to the bipolar part by an iterative procedure in a self-consistent way. Here we report the self-heating extension of HiSIM-IGBT, a compact model for power diode including the reverse recovery effect and the model application to accurate prediction of experimental switching characteristics.
STUDY OF Cr(VI) / TERTIARY AMINE REACTION KINETICS USING A MODIFIED ROTATING DIFFUSION CELL (2000)

ABSTRACT An investigation of the equilibrium and kinetic behaviour of Radiamine 6366, a tertiary amine dissolved in decane extracting Cr(VI) from acid solution is presented. Equilibrium and interfacial reaction models were used to describe the results obtained from shake tests and a modified Rotating Diffusion Cell. The modified cell allowed on-line measurement of the concentration in the aqueous phase. A second order forward reaction rate constant of 107 M−1s−1 was determined. It was shown that tri-butyl phosphate (TBP) was more surface active than Radiamine 6366 and with TBP addition, the interfacial reaction kinetics were slower.
Apparatus and method to achieve high-resolution microscopy with non-diffracting or refracting radiation (2023)

An imaging system employing a coded aperture mask having multiple pinholes is provided. The coded aperture mask is placed at a radiation source to pass the radiation through. The radiation impinges on, and passes through an object, which alters the radiation by absorption and/or scattering. Upon passing through the object, the radiation is detected at a detector plane to form an encoded image, which includes information on the absorption and/or scattering caused by the material and structural attributes of the object. The encoded image is decoded to provide a reconstructed image of the object. Because the coded aperture mask includes multiple pinholes, the radiation intensity is greater than a comparable system employing a single pinhole, thereby enabling a higher resolution. Further, the decoding of the encoded image can be performed to generate multiple images of the object at different distances from the detector plane. Methods and programs for operating the imaging system are also disclosed.
Variable Bit Rate Optical CDMA Networks Using Multiple Pulse Position Modulation (2007)

We have demonstrated multiple-pulse position modulation to achieve a variable bit rate OCDMA system, operating at different bit rates of 2.5, 4.3, and 5.7 Gbps, without changing pulse- width, encoders/decoders, and utilized bandwidth.