gebhart/patrepeval huggingface dataset:
Development of Cervical Spinal Cord Evoked Magnetic Field Measurement System Using SQUID Magnetometers (2009)

We are investigating an application of the biomagnetic measurement to non-invasive diagnosis of spinal cord function. Multichannel superconducting quantum interference device (SQUID) biomagnetometer systems for the measurement of the evoked magnetic field from spinal cords were developed as hospital-use apparatuses. The specific pattern transition of the spinal cord evoked field distribution was clearly observed. The conduction velocity of the cervical spinal cord, which is a significant information for the diagnosis of the dysfunction, was non-invasively estimated from the magnetic measurement.
Simulation of Leveling in Electrodeposition (1990)

A model of current distribution and electrode shape change for electrodeposition in the presence of diffusion‐controlled leveling agents has been developed. The system is treated as a special case of secondary current distribution, with the surface overpotential taken to depend on both the current density and the transport‐limited flux of the leveling agent, according to an empirical relation adapted from polarization data measured at different conditions of agitation. The spatial variation of the leveling‐agent flux is determined from a concentration field problem based on the assumption of a stagnant diffusion layer. The solution is obtained by the boundary element method, with a flexible moving‐boundary algorithm for simulating the advancement of the electrode profile. To illustrate the model's performance, the evolution of a groove profile during deposition of nickel from a Watts‐type bath containing coumarin is predicted and compared with measurements reported in the literature.
Melting of monolayer protected cluster superlattices (2000)

Melting of crystalline solids (superlattices) of octadecanethiol and octanethiol protected silver clusters has been studied with x-ray powder diffraction (XRD), differential scanning calorimetry (DSC), and infrared (IR) spectroscopy. These solids have been compared with the silver thiolate layered compounds in view of their similarity in alkyl chain packing and x-ray diffraction patterns. Superlattice melting is manifested in XRD around 400 K as the complete disappearance of all the low angle reflections; only bulk silver reflections due to the cluster cores are seen at 423 K. The superlattice structure is regained upon cooling from a temperature close to its melting point. However, cooling from a higher temperature of 473 K does not regain the superlattice order, whereas thiolate melting is repeatedly reversible even at these temperatures. Transmission electron microscopy suggests aggregation of clusters during heating/cooling cycles. DSC shows two distinct transitions, first corresponding to alkyl chain melting and the second corresponding to superlattice melting. Only alkyl chain melting is observed in variable temperature IR and increased order is manifested upon repeated heating/cooling cycles. Alkyl chain assembly shows strong interchain coupling leading to factor group splitting in cluster superlattices upon annealing. In thiolates only one melting feature is seen in DSC and it produces gauche defects, whereas significant increase in defect structures is not seen in superlattices. Repeated heating/cooling cycles increase interchain interactions within a cluster and the superlattice order collapses.
Re-Designing Principles For Computer Music Controllers : A Case Study Of Squeezevox Maggie (2009)

Description
Throwing Strategy in a Dual-Motor-Task of Aiming at the Bullseye while Walking in Virtual Reality (2022)

Humans perform movement tasks using motor and cognitive skills. The optimum outcome of the task is dependent on how the motor and cognitive skills are combined. When a dual-task is performed, this combination becomes even more important as the user has to devote limited available attention to the competing tasks. In this study, a ball throwing task to a specified location was performed in a virtual environment while the participant walked on a treadmill performing a dual-motor-task. Fifteen healthy participants took part in the study. The task paradigm involved three conditions - warm-up treadmill walking, throwing a ball to the target while standing, and throwing a ball to the target while walking on a treadmill. The throwing strategy was investigated with quantifiable task-space performance and scoring in the game. The correlation between the task-space performance and the cognitive tests was evaluated in the single and the dual-motor-task. Results demonstrate that during the throwing activity in the single and the dual-motor tasks, the choice of orienting the throwing plane in space was pre-determined prior to releasing the ball in a projectile motion and was interconnected with the motor ability. However, in dual-tasking, once the throwing plane was selected, the variation of hit point localization in the target plane was correlated with the cognitive ability. The task was executed with an allocation of motor and cognitive abilities to control specific performance variables while dual-tasking. This strategy potentially helped participants to reduce the load on attentional capacity during dual-tasking. This study showcases an optimized utilization of skill interaction to achieve the overall task objective. The paradigm designed in this work can be utilized to improve specific motor and cognitive skills by performing only one dual-motor-task.
Supplementary Table 1 from Genome-Wide Promoter Analysis Uncovers Portions of the Cancer Methylome (2023)

Supplementary Table 1 from Genome-Wide Promoter Analysis Uncovers Portions of the Cancer Methylome
Quantitative Comparison of Intracellular Unpacking Kinetics of Polyplexes by a Model Constructed From Quantum Dot-FRET (2008)

A major challenge for non-viral gene delivery is gaining a mechanistic understanding of the rate-limiting steps. A critical barrier in polyplex-mediated gene delivery is the timely unpacking of polyplexes within the target cell to liberate DNA for efficient gene transfer. In this study, the component plasmid DNA and polymeric gene carrier were individually labeled with quantum dots (QDs) and Cy5 dyes, respectively, as a donor and acceptor pair for fluorescence resonance energy transfer (FRET). The high signal-to-noise ratio in QD-mediated FRET enabled sensitive detection of discrete changes in polyplex stability. The intracellular uptake and dissociation of polyplexes through QD-FRET was captured over time by confocal microscopy. From quantitative image-based analysis, distributions of released plasmid within the endo/lysosomal, cytosolic, and nuclear compartments formed the basis for constructing a three-compartment first-order kinetics model. Polyplex unpacking kinetics for chitosan, polyethylenimine, and polyphosphoramidate were compared and found to correlate well with transfection efficiencies. Thus, QD-FRET-enabled detection of polyplex stability combined with image-based quantification is a valuable method for studying mechanisms involved in polyplex unpacking and trafficking within live cells. We anticipate that this method will also aid the design of more efficient gene carriers.
Dissection of the B10.D2 anti-H-2Kb cytolytic T lymphocyte receptor repertoire. (1980)

The B10.D2 cytolytic T lymphocyte (CTL) receptor repertoire specific for the H-2Kb alloantigen has been studied by determining the reactivity patterns of monoclonal CTL against a panel of seven different H-2Kb mutants. The repertoire is extremely diverse and contains a minimum of approximately 50 different specificities against unique antigenic determinants on the H-2Kb molecule. Each specificity appears at a maximum frequency of 1 in 18,000 CTL precursors. These studies have also served to dissect the antigenic composition of the H-2Kb molecule. Very few CTL clonotypes share recognition of all the mutants, thereby indicating the lack of conservation of a b-type antigenic region. In addition, the degree to which each mutant shares antigenic determinants with the standard H-2Kb molecule has been determined.
Vertical and Horizontal Transmission of Candida albicans in Very Low Birth Weight Infants Using DNA Fingerprinting Techniques (2008)

Both vertical and horizontal transmission contribute to Candida colonization of VLBW infants in the neonatal intensive care unit.
A study of the kinetics of diadamantylcarbene in solution by laser flash photolysis (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA study of the kinetics of diadamantylcarbene in solution by laser flash photolysisScott Morgan, Matthew S. Platz, Maitland Jones Jr., and David R. MyersCite this: J. Org. Chem. 1991, 56, 4, 1351–1353Publication Date (Print):February 1, 1991Publication History Published online1 May 2002Published inissue 1 February 1991https://pubs.acs.org/doi/10.1021/jo00004a003https://doi.org/10.1021/jo00004a003research-articleACS PublicationsRequest reuse permissionsArticle Views115Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Evaluation of a backside-illuminated ISIS (2008)

This paper presents preliminary evaluation results of a test sensor of the backside-illuminated ISIS, an ultra-high sensitivity and ultra-high speed CCD image sensor. To achieve ultra-high sensitivity, the CCD image sensor employs the following three technologies: backside illumination, cooling and Charge Carrier Multiplication (CCM). The test sensor has been designed, fabricated and evaluated. At room temperature without cooling, the video camera has about ten-time higher sensitivity than the previous one, which was supported by a conventional front side illumination technology. Furthermore, the video camera can detect images at very low signal level, less than 5 e-, by using CCM at -40 degree C.
Recombinant Influenza Virus Carrying the Respiratory Syncytial Virus (RSV) F 85-93 CTL Epitope Reduces RSV Replication in Mice (2013)

Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infections in infants worldwide. Despite decades of research, there is still no registered vaccine available for this major pathogen. We investigated the protective efficacy of a recombinant influenza virus, PR8/NA-F(85-93), that carries the RSV CD8(+) T cell epitope F(85-93) in its neuraminidase stalk. F(85-93)-specific cytotoxic T lymphocytes (CTLs) were induced in mice after a single intranasal immunization with PR8/NA-F(85-93) virus, and these CTLs provided a significant reduction in the lung viral load upon a subsequent challenge with RSV. To avoid influenza-induced morbidity, we treated mice with matrix protein 2 (M2e)-specific monoclonal antibodies before PR8/NA-F(85-93) virus infection. Treatment with anti-M2e antibodies reduced the infiltration of immune cells in the lungs upon PR8/NA-F(85-93) infection, whereas the formation of inducible bronchus-associated lymphoid tissue was not affected. Moreover, this treatment prevented body weight loss yet still permitted the induction of RSV F-specific T cell responses and significantly reduced RSV replication upon challenge. These results demonstrate that it is possible to take advantage of the infection-permissive protection of M2e-specific antibodies against influenza A virus to induce heterologous CD8(+) T cell-mediated immunity by an influenza A virus vector expressing the RSV F(85-93) epitope.
Supplementary Date (For Publication) from Targeting Hypoxic Prostate Tumors Using the Novel Hypoxia-Activated Prodrug OCT1002 Inhibits Expression of Genes Associated with Malignant Progression (2023)

&lt;p&gt;Supplementary Data contains Supplementary Table S1: Primer Sequences Supplementary Figure S1: Gene Layout on RealTime Ready custom 96 well panel Supplementary Figure S2: OCT1002 targets 22Rv1 and PC3 in hypoxic conditions Supplementary Figure S3: OCT1002 induces apoptosis in LNCAP-luc spheroids Supplementary Figure S4: Effect of bicalutamide and OCT1002 on tumor growth in 22Rv1 xenografts Supplementary Figure S5: Stereological analysis of microvessels in LNCaP tumors grown in window chambers Supplementary Figure S6: Effect of bicalutamide on oxygenation of 22Rv1 xenografts&lt;/p&gt;
Free radicals in the pathogenesis of diabetes and its complications (1995)

The successful defense against hostile and irritating influences is a remarkable ability of living structures. If they fail, they are condemned to death; if they are only partially successful, the result will be disease or aging. Free radicals seem to be the common effectors at the end of many chains of reaction triggered by exogenous and endogenous noxae. Thus coping with the production and defense of free radicals will be a major determinant of integrity or destruction of living structures. Diabetes mellitus is an apparent example of a disorder which is caused by free radicals and which itself results in their generation, thus producing secondary diseases. It is the aim of this review to describe our present knowledge of the role of free radicals in the pathogenesis of type 1 diabetes and to present some views of their role in the development of diabetic complications.
Harvesting renewable energy with chemistry (2017)

Guest Editors Walter Leitner, Elsje Alessandra Quadrelli and Robert Schlögl introduce the <italic>Green Chemistry</italic> themed issue on “Harvesting Renewable Energy with Chemistry”.
Figure S2 from Growth of Triple-Negative Breast Cancer Cells Relies upon Coordinate Autocrine Expression of the Proinflammatory Cytokines IL-6 and IL-8 (2023)

&lt;p&gt;Figure S2 - PDF file 1185K, Verification of IL-6, IL-8 and CXCL1 gene expression differences between triple-negative and ER-positive breast cancer cell lines&lt;/p&gt;
Fabrication of Hollow and Porous Tin-Doped Indium Oxide Nanofibers and Microtubes via a Gas Jet Fiber Spinning Process (2020)

We report the morphologies of tin-doped indium oxide (ITO) hollow microtubes and porous nanofibers produced from precursor solutions of polyvinylpyrrolidone (PVP), indium chloride (InCl<sub>3</sub>), and stannic chloride (SnCl<sub>4</sub>). The polymer precursor fibers are produced via a facile gas jet fiber (GJF) spinning process and subsequently calcined to produce ITO materials. The morphology shows strong dependence on heating rate in calcination step. Solid porous ITO nanofibers result from slow heating rates while hollow tubular ITO microfibers with porous shells are produced at high heating rates when calcined at a peak temperature of 700 °C. The mechanisms of formation of different morphological forms are proposed. The ITO fibers are characterized using several microscopy tools and thermogravimetric analysis. The concentration of inorganic salts in precursor solution is identified as a key factor in determining the porosity of the shell in hollow fibers. The data presented in this paper show that GJF method may be suitable for fabrication of hollow and multi-tubular metal oxide nanofibers from other inorganic precursor materials.
Integrated multi-sensors for ethanol measurement on the skin by perspiration (2016)

International audience
Foraging Among an Overabundance of Similar Variants (2016)

Foraging among too many variants of the same artifact can be problematic when many of these variants are similar. This situation, which is largely overlooked in the literature, is commonplace in several types of creative tasks, one of which is exploratory programming. In this paper, we investigate how novice programmers forage through similar variants. Based on our results, we propose a refinement to Information Foraging Theory (IFT) to include constructs about variation foraging behavior, and propose refinements to computational models of IFT to better account for foraging among variants.
NanoThermoMechanical AND and OR Logic Gates (2020)

Today's electronics cannot perform in harsh environments (e.g., elevated temperatures and ionizing radiation environments) found in many engineering applications. Based on the coupling between near-field thermal radiation and MEMS thermal actuation, we presented the design and modeling of NanoThermoMechanical AND, OR, and NOT logic gates as an alternative, and showed their ability to be combined into a full thermal adder to perform complex operations. In this work, we introduce the fabrication and characterization of the first ever documented Thermal AND and OR logic gates. The results show thermal logic operations can be achieved successfully through demonstrated and easy-to-manufacture NanoThermoMechanical logic gates.
Hierarchical model of the population dynamics of hippocampal dentate granule cells (2002)

A hierarchical modeling approach is used as the basis for a mathematical representation of the population activity of hippocampal dentate granule cells. Using neural field equations, the variation in time and space of dentate granule cell activity is derived from the summed synaptic potential and summed action potential responses of a population of granule cells evoked by monosynaptic excitatory input from entorhinal cortical afferents. In this formulation of the problem, we have considered a two-level hierarchy: the synapses of entorhinal cortical axons define the first level of organization, and dentate granule cells, which include these synapses, define the second, higher level of organization. The model is specified by two state field variables, for membrane potential and for synaptic efficacy, respectively, with both evolving according to different time scales. The two state field variables introduce new parameters, physiological and anatomical, which characterize the dentate from the point of view of neuronal and synaptic populations: (1) a set of geometrical constraints corresponding to the morphological properties of granule cells and anatomical characteristics of entorhinal-dentate connections; and (2) a set of neuronal parameters corresponding to physiological mechanisms. Assuming no interaction between granule cells, i.e., neither ephaptic nor synaptic coupling, the model is shown to be mathematically tractable and allows solution of the field equations leading to the determination of activity. This treatment leads to the definition of two state variables, volume of stimulated synapses and firing time, which describe observed activity. Numerical simulations are used to investigate the populational characterization of the dentate by individual parameters: (1) the relationship between the conditions of stimulation of active perforant path fibers, e.g., stimulating intensity, and activity in the granule cell layer; and (2) the influence of geometry on the generation of activity, i.e., the influence of neuron density and synaptic density-connectivity. As an example application of the model, the granule cell population spike is reconstructed and compared with experimental data.
Measurement of Five DOF Motion Errors in the Ultra Precision Feed Tables (2006)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Mapping and Ablation of Idiopathic Ventricular Fibrillation (2019)

Idiopathic ventricular fibrillation (IVF) is a major cause of unexplained sudden cardiac death of young patients under the age of 35. This chapter gives an overview of IVF mapping and ablation techniques of IVF. The site of earliest ventricular activation during spontaneous premature ventricular complexes (PVCs) is the target of choice. In patients without clinical PVCs, ablation can target the local Purkinje potentials or the site of best matched morphology by pace mapping. To date, the greatest experience with mapping and ablation of IVF was reported in a multicenter trial of 38 patients. After a mean follow-up of 63 months, 31/38 (82%) patients were free from ventricular fibrillation (VF) recurrence. VF recurrence occurred in the remaining seven (18%) patients after a median of four months, with multiple episodes in five patients. The presence of bundle branch block before ablation was the only parameter associated with worse outcome and with VF recurrence.
Supplementary Figure Legend from Targeting MYCN in Neuroblastoma by BET Bromodomain Inhibition (2023)

&lt;p&gt;PDF file - 35K&lt;/p&gt;
Data from CD40 Agonist Targeted to Fibroblast Activation Protein α Synergizes with Radiotherapy in Murine HPV-Positive Head and Neck Tumors (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;The incidence of human papillomavirus–associated head and neck squamous cell carcinoma (HPV&lt;sup&gt;+&lt;/sup&gt;-HNSCC) is rising worldwide and although current therapeutic modalities are efficient in the majority of patients, there is a high rate of treatment failures. Thus, novel combination approaches are urgently needed to achieve better disease control in patients with HPV&lt;sup&gt;+&lt;/sup&gt;-HNSCC. We investigated the safety and therapeutic efficacy of a novel fibroblast activation protein (FAP)-targeted CD40 agonist (FAP-CD40) in combination with local hypofractionated radiation in a syngeneic HPV&lt;sup&gt;+&lt;/sup&gt;-HNSCC model.&lt;/p&gt;Experimental Design:&lt;p&gt;Using an established orthotopic model, we treated tumor-bearing mice with local hypofractionated radiotherapy (2 × 6 Gy) alone or in combination with a systemic administration of the FAP-CD40 antibody. Following up the mice, we evaluated the changes in the tumor microenvironment (TME) by immunofluorescence, FACS, and NanoString RNA analysis.&lt;/p&gt;Results:&lt;p&gt;The suboptimal radiotherapy regimen chosen failed to control tumors in the treated mice. The FAP-CD40 administered in monotherapy transiently controlled tumor growth, whereas the combined therapy induced durable complete responses in more than 80% of the tumor-bearing mice. This notable efficacy relied on the radiotherapy-induced remodeling of the TME and activation of the CD8&lt;sup&gt;+&lt;/sup&gt; T-cell-cDC1 axis and was devoid of the systemic toxicity frequently associated with CD40-targeted therapy. Moreover, the robust immunologic memory developed effectively prevented tumor relapses, a common feature in patients with HNSCC.&lt;/p&gt;Conclusions:&lt;p&gt;Our study provides proof of concept, as well as mechanistic insights of the therapeutic efficacy of a bispecific FAP-CD40 combined with local radiotherapy in a FAP&lt;sup&gt;+&lt;/sup&gt;-HNSCC model increasing overall survival and inducing long-term antitumor immunity.&lt;/p&gt;&lt;/div&gt;