gebhart/patrepeval huggingface dataset:
Data from Long-term Follow-up and Correlative Analysis of Two Phase II Trials of Rituximab and Lenalidomide Followed by Continuous Lenalidomide in Untreated and Relapsed/Refractory Indolent Lymphoma (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;Rituximab and lenalidomide are effective for previously untreated and relapsed/refractory (R/R) indolent non-Hodgkin lymphoma (iNHL). However, long-term survival and predictive biomarkers are not well described.&lt;/p&gt;Patients and Methods:&lt;p&gt;We conducted two phase II open-label trials involving 60 patients with previously untreated and R/R advanced-stage iNHL. Patients received lenalidomide and rituximab induction followed by continuous lenalidomide until disease progression or unacceptable toxicity. The primary endpoint was overall response rate (ORR). Correlative studies included plasma cytokine monitoring, flow cytometry of peripheral blood mononuclear cells (PBMC; days 0, 15, 30, and 60), and RNA sequencing (RNA-seq) of pretreatment tumor biopsies.&lt;/p&gt;Results:&lt;p&gt;At a median follow-up of 63 months for previously untreated and 100 months for R/R, ORR was 82% for both. The 11 R/R patients who achieved complete remission remained in continuous remission for 16 to 141 months, thereafter. Median overall survival (OS) was not reached in the previously untreated and was 140 months (95% confidence interval, 53.4–140) in the R/R group. A mixed-effects linear regression model identified significant associations between Granzyme B&lt;sup&gt;+&lt;/sup&gt; (GranB&lt;sup&gt;+&lt;/sup&gt;) CD8&lt;sup&gt;+&lt;/sup&gt; T cells and long-term complete response (LTCR; &lt;i&gt;P&lt;/i&gt; = 5.3e-4). Furthermore, prior to start of therapy, treatment response could be predicted by B-cell and GranB&lt;sup&gt;+&lt;/sup&gt; CD8&lt;sup&gt;+&lt;/sup&gt; T-cell levels (% total lymphocytes).&lt;/p&gt;Conclusions:&lt;p&gt;Rituximab plus lenalidomide followed by continuous lenalidomide is effective with manageable toxicity in patients with previously untreated and R/R iNHL. This regimen produces durable remissions, even in heavily pretreated patients, with some lasting greater than 10 years. GranB&lt;sup&gt;+&lt;/sup&gt; CD8&lt;sup&gt;+&lt;/sup&gt; T cells, B cells, and plasma IFNγ allowed prediction of LTCR but need validation in larger trials.&lt;/p&gt;&lt;/div&gt;
Etude d'une nouvelle classe d'antenne imprimée à rayonnement monopolaire. Application aux téléphones mobiles (1996)

Ce memoire presente l'etude theorique et experimentale d'un mode de fonctionnement original des antennes imprimees lie a la presence d'un ou plusieurs fils de masse connectant le toit de l'antenne a son plan de masse. Les differentes analyses theoriques sont effectuees a l'aide d'un logiciel de calcul resolvant les equations de maxwell dans le domaine temporel selon la methode des differences finies. Pour permettre l'etude de l'antenne, des developpements ont ete apportes au logiciel existant. Ils concernent la technique de calcul du champ rayonne a l'infini, la methode de modelisation des fils fins et le calcul des conditions de stabilite de l'algorithme liees au traitement des fils. L'etude du comportement singulier aux basses frequences des antennes imprimees munies de fils de masse est l'objet d'une analyse electromagnetique approfondie. Elle est accompagnee d'une interpretation des phenomenes physiques et aboutit a la mise au point d'un nouveau mode de fonctionnement de ces antennes. Differents developpements sont presentes afin d'ameliorer et d'etendre ses performances. Les elements permettant de concevoir une antenne intrinsequement adaptee a son generateur sont presentes et les performances realisables avec ce type de dispositif rayonnant sont validees par les mesures effectuees sur differents prototypes. Finalement, le nouveau concept d'antenne est applique avec succes a la realisation d'une antenne miniature integree sur un combine telephonique mobile. L'influence exercee par le contexte d'utilisation tres particulier sur le fonctionnement de l'antenne est etudiee theoriquement et experimentalement.
The Burden of Cryptosporidium Diarrheal Disease among Children < 24 Months of Age in Moderate/High Mortality Regions of Sub-Saharan Africa and South Asia, Utilizing Data from the Global Enteric Multicenter Study (GEMS) (2016)

The enormous African/Asian Cryptosporidium disease burden warrants investments to develop vaccines, diagnostics and therapies.
The Challenges of Provisioning Real-Time Services in Wireless Internet (2000)

The issues involved in supporting real-time wireless Internet services go beyond the problem of forwarding packets to the correct destination of a mobile host. These issues include handover latency, availability of network resources after moving, and a proper charging and accounting infrastructure. Through a survey of current research in these areas, we discuss various concerns of integrating mobility, Quality of Service, and service charging techniques. Finally, we identify some open issues for future study.
Thomsen‐Friedenreich (T) antigen as marker of myoepithelial and basal cells in the parotid dand, pleomorphic adenomas and adenoid cystic carcinomas (1995)

Controversy centres on the role and identification of myoepithelial (MEC) and basal cells in salivary gland tumours, and recent studies suggest that both basal cells and myoepithelial cells participate in the formation of salivary gland tumours. We have correlated the expression of different well-known markers of normal MEC/basal cells (i.e. alpha-smooth muscle actin and cytokeratin 14) with T (Thomsen-Friedenreich) antigen and its sialylated derivative: sialosyl-T antigen,) in 17 normal parotid glands and in two tumour types with MEC participation (i.e pleomorphic adenomas (PA) and adenoid cystic carcinomas (ACC)) using immunohistology with well-defined monoclonal antibodies (MAbs). Paraffin-embedded/fresh frozen tissue sections were studied from 33/17 patients with PA and 15/7 patients with ACC. In normal parotid tissue coexpression of alpha-smooth muscle actin, cytokeratin 14, T and sialosyl-T antigens was found in all MEC and in some of the basal cells lining striated ducts. The remaining basal cells exclusively expressed cytokeratin 14, T and sialosyl-T antigens. In the tumours, cells believed to be modified myoepithelial cells showed two different staining patterns: 1) Coexpression of alpha-smooth muscle actin, cytokeratin 14, T and sialosyl-T antigens, and 2) Coexpression of cytokeratin 14, T and sialosyl-T antigens, but no alpha-smooth muscle actin. The epithelial ductular structures in the tumours showed aberrant expression of cytokeratin 14, T and sialosyl-T antigens, and cytokeratin 14 was the only marker of cells in solid undifferentiated areas of adenoid cystic carcinomas. Our study supports the view, that modified "myoepithelial" cells in the tumours consist of a mixture of basal cells and myoepithelial cells. None of the investigated structures was in itself an ideal marker in the identification of MEC/basal cells. The cells can be identified by a combination of markers (i.e. cytokeratin 14, alpha-smooth-muscle actin, T and sialosyl-T antigens).
Compensation and Emulation of Output Impedance in Ultra-High Bandwidth Class-D Power Amplifiers (2021)

The stability limits for an ultra-high bandwidth class-D power amplifier (100kHz, 800V DC-link, 10kW) are derived and characterized for two different use cases and for a given inductance of the line that connects the output of the converter to the load. In the first use case, the additional impedance due to the line is compensated and in the second use case, a controlled inner ohmic-inductive impedance is emulated by the converter. General stability analyses are conducted for simplified representations of the two control concepts, i.e., for compensating the line impedance and emulating an inner impedance. A detailed linearized model of the investigated power amplifier is used to evaluate the effectivenesses of both control concepts and to identify the stability boundaries that apply to the investigated converter system. By way of example, the compensation of the line impedance can decrease the total output impedance of the converter system due to a line inductance of 10µH from 1.3Ω to 0.37Ω at 20kHz. Furthermore, the compensation of the line impedance is found to be less prone to instability than the emulation of a defined inner impedance. With regard to the inner impedance emulation, the stability analysis discloses the dependency between the maximum allowable values of emulated inner inductance and inner resistance such that the system remains stable, which facilitates the evaluation of the implications of specific modifications of the converter hardware or changes of the structure of the control system on the stability boundaries. Without external inductance, a maximum inner inductance of 430µH at the stability limit is achieved if the bandwidth of the impedance emulation is limited to 30kHz. A detailed circuit simulation of the power stage and the digital control unit is used to verify the results of the analysis.
Effects of Sediment Characteristics on the Toxicity of Chromium(III) and Chromium(VI) to the Amphipod, Hyalella azteca (2004)

We evaluated the influence of sediment characteristics, acid-volatile sulfide (AVS) and organic matter (OM), on the toxicity of chromium (Cr) in freshwater sediments. We conducted chronic (28-42-d) toxicitytests with the amphipod Hyalella azteca exposed to Cr(VI) and Cr(III) in water and in spiked sediments. Waterborne Cr(VI) caused reduced survival of amphipods with a median lethal concentration (LC50) of 40 microg/L. Cr(VI) spiked into test sediments with differing levels of AVS resulted in graded decreases in AVS and sediment OM. Only Cr(VI)-spiked sediments with low AVS concentrations (< 1micromol/g) caused significant amphipod mortality. Waterborne Cr(III) concentrations near solubility limits caused decreased survival of amphipods at pH 7 and pH 8 but not at pH 6. Sediments spiked with high levels of Cr(III) did not affect amphipod survival but had minor effects on growth and inconsistent effects on reproduction. Pore waters of some Cr(III)-spiked sediments contained measurable concentrations of Cr(VI), but observed toxic effects did not correspond closely to Cr concentrations in sediment or pore waters. Our results indicate that risks of Cr toxicity are low in freshwater sediments containing substantial concentrations of AVS.
iNOS Expression In Dystrophinopathies Can Be Reduced By Somatic Gene Transfer of Dystrophin or Utrophin (2001)

These results suggest that iNOS could play a role in the physiopathology of DMD and that the abnormal expression of iNOS could be corrected by gene therapy.
Method for Bi-directional Conversion between Fundamental Gaussian Beams and Spatially Polarized Beams using a Spatial Light Modulator (2014)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Z. Zhao, Y. Ren, H. Huang, G. Xie, Y. Yan, N. Ahmed, C. Bao, L. Li, Y. Cao, and A. E. Willner, "Method for Bi-directional Conversion between Fundamental Gaussian Beams and Spatially Polarized Beams using a Spatial Light Modulator," in CLEO: 2014, OSA Technical Digest (online) (Optica Publishing Group, 2014), paper SM3J.4. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Putting the Fat and Water Protons to Work for You: A Demonstration Through Clinical Cases of How Fat-Water Separation Techniques Can Benefit Your Body MRI Practice (2013)

As technology has advanced, fat-water separation techniques have shown that they can be valuable tools for a body MRI practice, particularly when the presence or absence of fat, homogeneity of fat saturation, coregistration, or quantitative evaluation is critical.
Applying the Business Excellence Model to a Research Organization (2005)

What exactly does quality management in research mean? This remains a question frequently asked by managers and staff of industrial research laboratories. Surrounding business functions like marketing, manufacturing, logistics, finance, and even development and engineering, are--sometimes enthusiastically--engaged in quality programs. They do not seem to experience the difficulties Research has in answering the aforementioned question for their own function. Experience at technology-intensive industrial research organizations has convinced us that the application of traditional management principles to a research environment is often counterproductive. These principles are largely aimed at improving upon what already exists, while industrial research requires renewal, breakthrough innovation and out-of-the-box thinking. It is for this reason that over the past several years we have developed a research-specific application of the well-known EFQM Business Excellence model (see illustration, next page) and experimented with it at Philips Research Labs and Shell Exploratory Research. The research-specific application of the model is predominantly based on two choices: taking a research perspective rather than an RD discourage territorial and competence conflicts (for example, by planning and budgeting at high hierarchical levels for large parts of the organization instead of having budgets for every small research group). * Encourage researchers to network and write articles; have them initiate and maintain contacts with the global scientific community as well as with colleagues from other industrial laboratories and governmental institutions in order to share knowledge and discover opportunities to create new knowledge (2). …
Structure of nucleic acid bases in calf thymus DNA modified by the potent mutagen, 10-azabenzo(a)pyrene-4,5-oxide. (1983)

Modified nucleic acid bases were isolated from the hydrolysates of calf thymus DNA bound with 10-azabenzo[a]pyrene-4, 5-oxide. The structures of two modified cytosines were proposed.
Conformational Sampling of Macrocyclic Drugs in Different Environments: Can We Find the Relevant Conformations? (2018)

Conformational flexibility is a major determinant of the properties of macrocycles and other drugs in beyond rule of 5 (bRo5) space. Prediction of conformations is essential for design of drugs in this space, and we have evaluated three tools for conformational sampling of a set of 10 bRo5 drugs and clinical candidates in polar and apolar environments. The distance-geometry based OMEGA was found to yield ensembles spanning larger structure and property spaces than the ensembles obtained by MOE-LowModeMD (MOE) and MacroModel (MC). Both MC and OMEGA but not MOE generated different ensembles for polar and apolar environments. All three conformational search methods generated conformers similar to the crystal structure conformers for 9 of the 10 compounds, with OMEGA performing somewhat better than MOE and MC. MOE and OMEGA found all six conformers of roxithromycin that were identified by NMR in aqueous solutions, whereas only OMEGA sampled the three conformers observed in chloroform. We suggest that characterization of conformers using molecular descriptors, e.g., the radius of gyration and polar surface area, is preferred to energy- or root-mean-square deviation-based methods for selection of biologically relevant conformers in drug discovery in bRo5 space.
Fabrication and stacking of through-silicon-via array chip formed by notchless Si etching and wet cleaning of first metal layer (2019)

Abstract We combined a “via-last through-silicon via (TSV) process consisting of notchless Si etching and wet cleaning of the first metal layer” with the solder bonding process using Ar fast atom beam (FAB), and realized the fabrication and three-dimensional (3D) stacking of a high-density TSV array chip. The size of the TSV array was 76 × 500. The diameter and length of the TSV were 6 and 21–22 μ m, respectively. As the TSV array chip was very thin (approximately 26 μ m) and had a strip-like shape, it was fragile and warped by approximately 90 μ m. Hence, an electrostatic chuck was introduced and the TSV array chip was stacked by using a soft material (Cu–Ni–Sn based solder) as a bump and performing low-pressing-load low-temperature bonding with Ar FAB. As a result, the warpage of TSV array chip was suppressed and the TSV array chip was stacked without causing damage to the TSV and Si region. In addition, it was confirmed that the (i) leakage current between TSV-bump pairs is small, (ii) multilayer wiring + TSV + bump connection exhibit low resistance, and (iii) daisy chain is perfectly connected to up to 38 000 TSVs. These results are due to the effects of notchless Si etching, wet cleaning of the first metal layer, introduction of an electrostatic chuck, low-pressing-load low-temperature bonding with a soft material, and Ar FAB. This process will facilitate the development of face-up type 3D stacked sensor systems.
Dendritic Cell Amplification of HIV Type 1-Specific CD8 + T Cell Responses in Exposed, Seronegative Heterosexual Women (2002)

In the Heterosexual AIDS Transmission Study (HATS), the frequency of high-risk sexual activity and viral load in the seropositive partner were shown to correlate with HIV-1 transmission. However, these parameters could not account for the status of some exposed, seronegative (ESN) individuals who remained uninfected despite years of exposure. To test the hypothesis that antiviral immune responses are a correlate of nontransmission in this cohort, we developed two sensitive methods for assessing HIV-1-specific humoral and cell-mediated responses. To quantify T cell responses, autologous mature dendritic cells (DCs) were used as antigen-presenting cells to elicit HIV-1-specific IFN-gamma production by ELISPOT. Antibody responses to HIV-1 gp120 were assessed by combination immunoprecipitation-Western blot (IP-WB). Previous studies of this cohort, using limiting dilution analysis, did not reveal HIV-1-specific cytotoxic T lymphocyte activity. However, when autologous DCs were used to present HIV-1 antigens, T cells from three of eight ESN women (38%) responded by producing IFN-gamma. T cells from three of four seropositive partners responded to HIV-1 antigens, whereas five negative controls did not. The use of DCs as antigen-presenting cells increased sensitivity by 2- to 30-fold relative to standard ELISPOT. Using IP-WB, low levels of gp120-reactive antibodies were detected in plasma from 1 of 14 ESN women. These results support the hypothesis that HIV-1-specific T cell responses play a role in immune surveillance in this cohort of North American serodiscordant couples. This report also demonstrates the ability of dendritic cells to reveal T cell responses that might be overlooked by other methods.
Assessing cognitive impairment in SLE: examining relationships between resting glucose metabolism and anti-NMDAR antibodies with navigational performance (2019)

SNT performance is associated with serum DNRAb titres and resting glucose metabolism in the anterior putamen/caudate and frontal cortex, suggesting compensatory neural recruitment in SNT-associated regions is necessary for successful completion of the task. The SNT therefore has potential for use as a marker for SLE-mediated cognitive impairment.
A study of echo in VoIP systems and synchronous convergence of the μ-law PNLMS algorithm (2006)

A recent algorithm, the mu-law PNMLS, introduces a stepsize proportionate to the mu-law of the estimated tap coefficient to cancel sparse echo in telephony over packet-switch networks. It is derived by optimizing the following criterion: fastest convergence is obtained when all coefficients reach the vicinity of their target value at the same time. We present a study of synchronous convergence as introduced in this algorithm. Simulations for a 2-tap adaptive filter illustrate the optimality of mu-law PNLMS. We then compare the performances of this algorithm on multiple echo paths. This comparison shows some restrictions in the applicability of the optimality criterion and highlights possible improvements in robustness for this algorithm.
Exploring schema similarity at multiple resolutions (2010)

Large, dynamic, and ad-hoc organizations must frequently initiate data integration and sharing efforts with insufficient awareness of how organizational data sources are related. Decision makers need to reason about data model interactions much as they do about data instance interactions in OLAP: at multiple levels of granularity. We demonstrate an integrated environment for exploring schema similarity across multiple resolutions. Users visualize and interact with clusters of related schemas using a tool named Affinity. Within any cluster, users may drill-down to examine the extent and content of schema overlap. Further drill down enables users to explore fine-grained element-level correspondences between between two selected schemas.
A 60-GHz Symmetric Doherty Power Amplifier with 20.4% 6-dB Back-off Efficiency (2019)

A reduced-complexity symmetric Doherty power amplifier (PA) for 60 GHz band is demonstrated in 45nm CMOS silicon on insulator. The output network is synthesized for reduced components to obtain low combiner loss and high back-off efficiency. The achieves a measured output power of 14 dBm and a measured power-added efficiency (PAE) at 6-dB back-off of 20.4%, which verifies the advantage of the proposed combiner design.
Incidence and Risk Factors of Symptomatic Hiatal Hernia after Resection for Gastric and Esophageal Cancer (2016)

Andreou, Andreas MD; Struecker, Benjamin MD; Sauer, Igor M. MD; Bahra, Marcus MD; Denecke, Christian MD; Chopra, Sascha S. MD; Pratschke, Johann MD, PhD, FACS; Biebl, Matthias MD Author Information
Phosphatidylglycerols are induced by gut dysbiosis and inflammation, and favorably modulate adipose tissue remodeling in obesity (2019)

Lipidomic techniques can improve our understanding of complex lipid interactions that regulate metabolic diseases. Here, a serum phospholipidomics analysis identified associations between phosphatidylglycerols (PGs) and gut microbiota dysbiosis. Compared with the other phospholipids, serum PGs were the most elevated in patients with low microbiota gene richness, which were normalized after a dietary intervention that restored gut microbial diversity. Serum PG levels were positively correlated with metagenomic functional capacities for bacterial LPS synthesis and host markers of low-grade inflammation; transcriptome databases identified PG synthase, the first committed enzyme in PG synthesis, as a potential mediator. Experiments in mice and cultured human-derived macrophages demonstrated that LPS induces PG release. Acute PG treatment in mice altered adipose tissue gene expression toward remodeling and inhibited ex vivo lipolysis in adipose tissue, suggesting that PGs favor lipid storage. Indeed, several PG species were associated with the severity of obesity in mice and humans. Finally, despite enrichment in PGs in bacterial membranes, experiments employing gnotobiotic mice colonized with recombinant PG overproducing Lactococcus lactis showed limited direct contribution of microbial PGs to the host. In summary, PGs are inflammation-responsive lipids indirectly regulated by the gut microbiota via endotoxins and regulate adipose tissue homeostasis in obesity.-Kayser, B. D., Lhomme, M., Prifti, E., Da Cunha, C., Marquet, F., Chain, F., Naas, I., Pelloux, V., Dao, M.-C., Kontush, A., Rizkalla, S. W., Aron-Wisnewsky, J., Bermúdez-Humarán, L. G., Oakley, F., Langella, P., Clément, K., Dugail, I. Phosphatidylglycerols are induced by gut dysbiosis and inflammation, and favorably modulate adipose tissue remodeling in obesity.