gebhart/patrepeval huggingface dataset:
A Role for Survivin in Enucleation of Erythroid Progenitors. (2007)

Abstract Enucleation is the final step in the development of reticulocytes and this process is unique to mammalian red blood cells among vertebrates. Even though enucleation of erythroblasts was structurally studied by electron microscopy half a century ago, little is known about the underlying mechanism. Initially it was thought that enucleation involved degradation of DNA and other apoptotic processes. More recently it has been shown that enucleation of erythroid progenitors does not require major apoptotic machinery including caspase-3 activation (Krauss et al, 2005; Yoshida et al, 2005). Alternatively, it has been suggested that enucleation in erythroblasts is a result of asymmetric cytokinesis. In support of this later model, survivin, a regulator of chromosomal segregation and cytokinesis, which also has an anti apoptotic role, is highly expressed in orthochromatic erythroblasts, cells at the stage of differentiation just prior to enucleation (Gurbuxani et al, 2005). Moreover conditional heterozygous deletion of survivin in hematopoietic cells caused a decrease in enucleated cells in the spleen (Leung et al, 2007). This has led us to hypothesize that survivin has a role in enucleation of erythroblasts. To test this prediction, we first over expressed survivin in MEL (murine erythroleukemia) cells and then subjected them to DMSO induced differentiation. Normally MEL cells decrease their survivin expression level upon differentiation and at the same time undergo limited enucleation (&amp;lt;4%) even after 5 days of differentiation. In contrast, survivin overexpressing clones consistently enucleated 3–5 fold more than control cells, suggesting that levels of survivin are likely to be important for enucleation. We are currently harnessing the power of survivin antisense nanoparticle agents to assess the specific requirement of survivin in enucleation of primary human orthochromatic erythroblasts. Separately, we evaluated the localization of survivin and its known partners in enucleating primary human erythroid cells by confocal microscopy. Survivin is predominantly localized to the cytoplasmic compartment and to our surprise did not colocalize with Aurora B kinase and INCENP, two of its partners in the chromosomal passenger complex, which is essential for mitosis. On the contrary, we noticed that survivin partially colocalized with actin at the junction between the extruding nucleus and cytoplasm, as well as in the periphery of cytoplasm in these enucleating cells. Moreover enucleation assays performed in the presence of various inhibitors of cell cycle and cytokinesis did not prevent enucleation in erythroblasts. Taken together, these findings demonstrate that enucleation is not a form of cytokinesis and further suggest that survivin participates in enucleation by a novel mechanism.
Growth-modulating agents for the synthesis of Al-MOF-type materials based on assembled 1D structural subdomains (2018)

Novel aluminium MOF-type materials structured by 1D subdomains, such as organic-inorganic nanoribbons, were synthesized by modifying the conditions of solvothermal synthesis and the nature of the solvents in the presence of aryl monocarboxylate linkers with long alkyl chains, which acted as growth-modulating agents. Specifically, three different families of materials were prepared with various morphological characteristics: (i) isoreticular MIL-53(Al)-type materials, (ii) mesoscopic metalorganic structures and (iii) lamellar aluminium MOFs. The length of the alkyl chain in the aryl linker and the hydrophobic/hydrophilic nature of the solvothermal synthesis media determined the structuration level that was achieved. The derived Al-MOFs are active and stable catalysts for the synthesis of fine chemicals. This was illustrated by the efficient synthesis of 2,3-dihydro-2,2,4-trimethyl-1H-1,5-benzodiazepine.
Toughening of Epoxy Resin Networks with Functionalized Engineering Thermoplastics (1993)

Epoxy resin thermosets are traditionally toughened by the incorporation of an elastomeric component that phase-separates during cure to form a multiphase network. The toughness enhancement in these systems is considerable. However, in most instances, toughness enhancement is achieved at the expense of stiffness and high-temperature performance. An alternative approach to increasing the toughness and impact strength involves the use of functionalized engineering thermoplastics as toughening agents. The improvement in toughness is accomplished in this case without significant sacrifice of properties at elevated temperatures. In this chapter, a brief review of the state of the art of thermoplastic-modified epoxy resin networks is presented. Emphasis is placed on the types of modifiers, morphological character, and the various mechanisms proposed to be responsible for the toughening behavior.
Therapeutic ultrasound: Recent trends and future perspectives (2010)

Before ultrasound-imaging systems became widely available, ultrasound therapy devices showed great promise for general use in medicine. However, it is only in the last decade that ultrasound therapy has begun to obtain clinical acceptance. Recently, a variety of novel applications of therapeutic ultrasound have been developed that include sonothrombolysis, site-specific and ultrasound-mediated drug delivery, shock wave therapy, lithotripsy, tumor ablation, acoustic hemostasis and several others. This paper reviews a few selected applications of therapeutic ultrasound. It will address some of the basic scientific questions and future challenges in developing these methods and technologies for general use in our society. As a plenary presentation, its audience is intended for the ultrasound scientist or engineer, and thus is not presented at the level of the experienced medical ultrasound professional.
Broadband Triple-Frequency Microstrip Patch Radiator Combining a Dual-Band Modified Sierpinski Fractal and a Monoband Antenna (2006)

A triple-frequency antenna combining a dual-band and a monoband antenna with broadside radiation patterns is presented. The dual-band antenna is inspired in the Sierpinski fractal. Such a dual-band antenna is stacked over a monoband antenna. The antenna presents a broadband behavior at each band thanks to parasitic patches. The antenna has been designed using a MoM commercial code and has been experimentally tested, obtaining three bands with a broad bandwidth, high efficiency, and similar radiation patterns
Development and Evaluation of Light-Weight Active Noise Cancellation Earphones (2018)

This paper presents the development of active noise control (ANC) for light-weight earphones, and proposes using music or natural sound to estimate the critical secondary path model instead of extra random noise. Three types of light-weight ANC earphones including in-ear, earbud, and clip phones are developed. Real-time experiments are conducted to evaluate their performance using the built-in microphone inside KEMAR’s ear and to compare with commercially-available ANC headphones and earphones. Experimental results show that the developed light-weight ANC earphones achieve higher noise reduction than the commercial ANC headphones and earphones, and the in-ear ANC earphone has the best noise reduction performance.
Abstract 16144: Regional Variations in Mortality in Patients With Heart Failure Across Asia: Outcomes in the ASIAN-HF Registry (2017)

Introduction: Heart failure(HF) is a global epidemic. Despite Asia holding 60% of the world’s population, there is a paucity of comparative outcome data in patients with HF across Asia. Methods: AS...
1660: Year of Surgery is an Independent Predictor of Biochemical Failure Following Radical Prostatectomy for Prostate Cancer (2005)

You have accessJournal of UrologyModerated Poster, Wednesday, May 25, 2005, 3:30 - 5:30 pm1 Apr 20051660: Year of Surgery is an Independent Predictor of Biochemical Failure Following Radical Prostatectomy for Prostate Cancer Robert E. Mitchell, Jay B. Shah, Eric T. Goluboff, Aaron E. Katz, Carl A. Olsson, Mitchell C. Benson, and James M. McKiernan Robert E. MitchellRobert E. Mitchell More articles by this author , Jay B. ShahJay B. Shah More articles by this author , Eric T. GoluboffEric T. Goluboff More articles by this author , Aaron E. KatzAaron E. Katz More articles by this author , Carl A. OlssonCarl A. Olsson More articles by this author , Mitchell C. BensonMitchell C. Benson More articles by this author , and James M. McKiernanJames M. McKiernan More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)35782-3AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "1660: Year of Surgery is an Independent Predictor of Biochemical Failure Following Radical Prostatectomy for Prostate Cancer." The Journal of Urology, 173(4S), p. 450 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 173Issue 4SApril 2005Page: 450 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Robert E. Mitchell More articles by this author Jay B. Shah More articles by this author Eric T. Goluboff More articles by this author Aaron E. Katz More articles by this author Carl A. Olsson More articles by this author Mitchell C. Benson More articles by this author James M. McKiernan More articles by this author Expand All Advertisement PDF downloadLoading ...
Preparation and Biological Activities of a Bivalent Poly(Ethylene Glycol) Hybrid Containing an Active Site and Its Synergistic Site of Fibronectin. (2002)

A bivalent poly(ethylene glycol) or PEG hybrid of fibronectin-related peptides was prepared. An active site peptide (RGD) and its synergistic site peptide (PHSRN) of fibronectin were conjugated with an amino acid-type PEG (aaPEG) to form PHSRN-aaPEG-RGD. A moderate spatial array between RGD and PHSRN in fibronectin may be required for synergic activity. The bivalent hybrid exhibited potent cell spreading activity and exhibited potent anti-metastatic activity in a model of experimental metastasis with B16-BL6 cells in mice. PEG may serve as a spacer for maintaining the desired spatial array.
Object i.e. aneurysm, examining method for brain of patient, involves evaluating sequence of images by associating pixels with analysis image value depending on temporal changes of image values of pixels in specified frequency range (2009)

NOVELTY - The method involves illuminating an object i.e. aneurysm, with measuring light with wavelengths ranging from 790 nanometer to 820 nanometer, and recording a sequence of images (21, 22) i.e. white light image, of the illuminated object. The sequence of images is evaluated by associating pixels in the sequence of images to which locations of the object are imaged with an analysis image value. The analysis image value depends on temporal changes of image values of the pixels in the sequence of images in a frequency range of below 100 Hertz.
Modeling the stochastic behavior of lupus (2014)

The protracted diagnostic period and variable disease presentation not only complicate diagnosing SLE but also the epidemiologic study of it. Coupled with the remitting and relapsing nature of the disease and the challenges in managing it, clinical research in lupus requires careful attention to study design, control selection, temporality, and many often overlooked issues in the analysis phase. Between "big data" and the impressive advances in the basic sciences, it is tempting to either oversimplify methods to take advantage of "big data" or overcomplicate because the problem itself is complicated. As we revisit the building blocks of epidemiologic research, we will uncover opportunities to move epidemiology and clinical research forward in SLE. Why do we care about effect modification and what is it? Why can we not just adjust for everything that we want to? And perhaps, most importantly, going back to the very beginning and asking ourselves: does this matter? During this talk we will discuss issues relating to case identification methods, potential biases associated with control selection, and return to the basics of epidemiologic research. Although we shall discuss these issues in the context of environmental (nongenetic) factors, these concerns extend across the worlds of observational data analysis, can impact randomized trials, and are relevant for all types of exposures and outcomes.
Gamma Comprehensive Normalisation (2002)

The light reflected from an object depends not only on surface reflectance of the object but also on lighting geometry and illuminant color. As a consequence, the raw color recorded by a camera is not a reliable cue for color based tasks such as object recognition and tracking. One solution to this problem is to find color invariants which are independent of illumination. While many invariant functions cancel out dependency due to geometry and light color it is less easy to remove both dependencies. The comprehensive normalisation removes both geometry and color but at the cost of an iterative procedure. In earlier work we showed how the need for iteration could be removed by carrying out normalisations in the log color domain. However, we have found that both these normalisations, though theoretically sound, do not account for all dependencies that might realistically be present.Indeed, in image processing pipelines it is common to raise an image to the power of gamma either to change the contrast (see into shadows or highlights) or to account for display non-linearities. In this paper we ask, &#x201C;for systems to which gamma functions are applied, how can we make the invariant approach work to facilitate color based object recognition?&#x201D; Clearly we need to deal with gamma and develop a framework where gamma is removed. This is the major contribution of this paper. We show how a simple extension of the log normalisation strategy also suffices to remove gamma. We tested our method both on linear and nonlinear datasets. While producing similarly results for linear dataset as our previous methods, our new method significantly outperformed previous methods for the nonlinear dataset.
Demonstration of new planar capacitor (PCAP) vehicles to evaluate dielectrics and metal barrier thin films (2015)

Planar capacitors can quickly test material properties of metals and dielectrics for interconnects. A sidewall capacitor device is used to evaluate metal thin-film barriers. Etch stop planar capacitors in turn can test multi-layer etch stops, exposing differences between leaky and good etch stop films. Fillable planar capacitors are also fabricated and results presented for that class of fill materials.
Laboratory Production of Tornado–Like Vortices (1974)

Tornado formation by turbulent mixing of two horizontal air currents and a vertical downdraft, as in the Wokingham model, has been simulated in the laboratory. Without the presence of the downdraft, vertices with lifetimes up to 20 see have been produced only when the horizontal air currents have an angular separation of 65°. Maximum stability occurs when one current is inclined 6° above the horizontal. Results suggest that tornado formation probability is independent of downdraft and critically dependent on local wind directions and geometries at intermediate altitudes in severe local storms.
Purkinje network and myocardial substrate at the onset of human ventricular fibrillation: implications for catheter ablation (2021)

The onset of human VF is mostly associated with activities from the Purkinje network and structural substrate, before spreading throughout the ventricles to establish sustained VF. Targeted ablation reduces or eliminates VF recurrence.
Classification of Hand Motion Using Surface EMG Signals (2012)

The human hand has multiple degrees of freedom (DOFs) to achieve high dexterity. Identifying the five-finger movements using surface electromyography (sEMG) is challenging. Moreover, the success rate of identifying the hand movements is sensitive to many aspects; for example, the sEMG electrode placements, variant movement forces, or movement speeds. In this chapter, a robust sEMG system for identifying the hand movements is developed. First, a multichannel sEMG sensor ring is designed, which is easy to wear on the human forearm even without knowledge of the exact location of the corresponding muscles. However, a new problem of using the multichannel sensor ring is followed and unsolved in the current research. The problem is how to relocate the sEMG electrodes with the same sequence as the last trial. This chapter introduces the concordance correlation coefficient to investigate the 220relationships of all channels, and autorelocation of the sEMG electrodes is possible. The process of the successful hand motion classification can be divided into collecting original sEMG signals, calculating features basd on original signals, and classifying motions based on features. If the calculated features are robust to some variances in the movement forces and speed, the motion classification results also have robustness. Thus, to make classification of the hand movements robust to some variances in the movement forces and speed, a new ratio measure of the multiple channels is defined as the feature, which is based on the results of the temporal square integral values of each channel signal. Finally, real-time classification of the hand movements is possible, using the statistical classifier based on Mahalanobis distance. In addition to classification of the hand movement types, knowing the movement force and the movement speed are important. In this chapter, the levels of the movement forces are described using spectral moments based on the short-time Fourier transform (STFT) results. The levels of the movement speeds, which are seldom studied in the current research, are also identified. Based on the results of STFT, the spectral flatness feature is firstly introduced for the sEMG signal to describe the different speeds of the hand movements.
SOIL DRYNESS AND ITS EFFECT ON TOXIC COPPER MOBILITY (2021)

By Hossam Altaher, Andrea Dietrich & 1 more. A laboratory study to determine if agricultural copper can migrate in soil and to determine the mechanisms that account for the movement through soil to the subsurface.
Input voltage pumping control for a multi-level switching amplifier (2007)

The paper describes energy pumping among dc busses in a multilevel inverter with isolated power supplies driving a passive load, and an algorithm to eliminate it. In the current switching amplifier application, the output current waveforms are required to be of almost arbitrary shape. Modulation techniques are known to be well suited for conventional inverter operation, however when driving some output current waveforms, they can produce dc bus over voltages due to an undesired energy transfer between busses. The specific cases that cause the pumping are described and an algorithm is proposed that eliminates the effect without disturbing the correct operation of the inverter. The algorithms have been tested in a prototype to verify the expected performance.
FELLOWSHIP-TRAINED ORTHOPAEDIC TRAUMATOLOGISTS ACHIEVE BETTER POSTOPERATIVE RADIOLOGICAL PARAMETERS AFTER CEPHALOMEDULLARY NAILING OF INTERTROCHANTERIC FRACTURES COMPARED WITH COMMUNITY SURGEONS (2023)

Intertrochanteric fractures are common, accounting for nearly 30% of all fracture related admissions. Some have suggested that these fractures should be treated in community hospitals so as not to tax the resources of Level One trauma centers. Since many factors predictive of fixation failure are related to technical aspects of the surgery, the purpose of this study was to compare radiographic parameters after fixation comparing trauma fellowship trained surgeons to non-fellowship trained community surgeons to see if these fractures can be treated successfully in either setting. Using our hospital system's trauma database, we identified 100 consecutive patients treated with cephalomedullary nails by traumatologists, and 100 consecutive patients treated by community surgeons. Quality of reduction, neck shaft angle (NSA), tip-to apex distance (TAD) were compared. The mean TAD for the trauma group was 10mm compared to 21mm for the community group (p&lt;0.001). The mean postoperative NSA for the trauma group was 133 degrees compared to 127 degrees for the community group (p&lt;0.001). The mean difference in the NSA of the fractured side compared to the normal hip was 2.5 degrees of valgus in the trauma group compared to 5 degrees of varus for the community group (p&lt;0.001). There were 93 good reductions in the trauma group compared to 19 in the community group (p&lt;0.001). There were no poor reductions in the trauma group and 49 poor reductions in the community group (p&lt;0.001). Fellowship trained traumatologists achieved significantly more accurate reductions and implant placement during cephalomedullary nailing of intertrochanteric hip fractures.
MAKING OPTICAL WAVES, TRACING ELECTRONS IN REAL-TIME: THE ONSET OF THE ATTOSECOND REALM (Invited Review) (2014)

Tracing the dynamics of electrons inside atoms molecules or solids as they occur in real time resides at the forefront of modern science and technology. Advances in attosecond physics over the last decade and beyond are now enabling this essential experimental capability. Here we discuss some of the key developments in light sciences that made possible attosecond metrology and control of electronic processes inside matter on native time scales. These developments hold the promise for new, fundamental insights into the innerworkings of the microcosm as well as the identification of innovative routes for light-based electronic and photonic devices operating at PHz rates.
Structural and electronic properties of the one-dimensional organic metal bis(thiodimethylene)-tetrathiafulvalene tetracyanoquinodimethane (1995)

The synthesis and structural characterization at room temperature and 130 K of the organic charge-transfer salt bis(thiodimethylene)-tetrathiafulvalene tetracyanoquinodimethane (BTDMTTF-TNCQ) is reported. X-ray diffuse scattering as well as ir and Raman measurements show that the charge transfer in this salt is \ensuremath{\sim}0.5. BTDMTTF-TCNQ remains metallic down to very low temperatures but exhibits an anomaly at 175 K in the conductivity and thermopower which could be related to some unusual structural modification of the unit cell. Band-structure calculations show that this salt is a narrow-band one-dimensional metal. The high value of the spin susceptibility, the low value of the conductivity, and the observation of a 4${\mathit{k}}_{\mathit{F}}$ charge-density-wave (CDW) instability around room temperature prove that it is a highly correlated metal. In contrast with other salts of the TTF-TCNQ family, BTDMTTF-TCNQ does not exhibit critical 2${\mathit{k}}_{\mathit{F}}$ structural fluctuations. It is proposed that the absence of the 2${\mathit{k}}_{\mathit{F}}$ CDW transition is due to the stronger interlocking of the donor and acceptor molecules due to the presence of the sulfur atoms in the central position of the outer five-membered rings of the BTDMTTF donor.