gebhart/patrepeval huggingface dataset:
Starija životna dob i rak (2005)

Produženje ocekivanog trajanja života i povecanje broja starijeg stanovnistva ima za posljedicu veci broj oboljelih i umrlih od raka, sto je sada slucaj u Hrvatskoj. Najcesca sijela raka u starijoj dobi jesu u muskaraca bronh i pluca, prostata, debelo crijevo, želudac, mokracni mjehur i grkljan, a u žena dojka, debelo crijevo, želudac, bronh i pluca i tijelo maternice. Važno je usvajanje, odnosno održavanje zdravih životnih navika jer iste utjecu na smanjeni rizik obolijevanja. Uspjesnost lijecenja ovisi pak primarno o ranom otkrivanju bolesti. Osim samopregleda, sto je posebice važno za kožu, postoje mogucnosti za rano otkrivanje raka dojke, maternice, debelog crijeva i prostate. Sanse za izlijecenje u starijih osoba slabije su zbog prisutnih kronicnih bolesti, narusenoga funkcionalnog statusa te težeg podnosenja agresivnih terapija. Prvi korak u donosenju odluke o probiru kao i terapiji jest sveobuhvatna gerijatrijska obrada pacijenta koja ukljucuje evaluaciju svih komorbidnih stanja, stupanj polifarmacije i prisutnost gerijatrijskih sindroma. S obzirom na specificnost problematike malignih bolesti u starijim dobnim skupinama, javlja se potreba za razvojem gerijatrijske onkologije kao posebne klinicke specijalnosti.
Imaging of cardiac pacemakers. (1997)

November 1997Imaging of cardiac pacemakers.Authors: S M Bejvan, J H Ephron, J E Takasugi, J D Godwin, and G H BardyAuthor Info & AffiliationsVolume 169, Issue 5https://doi.org/10.2214/ajr.169.5.9353461 METRICS PDFotherformats
$\mathrm{\Lambda_{c}^{+}}$ production in pp and in p-Pb collisions at $\sqrt{s_{\rm {NN}}} = 5.02$ TeV (2020)

The production cross section of prompt $\mathrm{\Lambda_{c}^{+}}$ charmed baryons was measured with the ALICE detector at the LHC at midrapidity in proton-proton (pp) and proton-lead (p-Pb) collisions at a centre-of-mass energy per nucleon pair of $\sqrt{s_\mathrm{NN}} = 5.02$ TeV. The $\mathrm{\Lambda_{c}^{+}}$ and $\rm {\overline{\Lambda}{}_c^-}$ baryons were reconstructed in the hadronic decay channels $\rm \Lambda_{c}^{+} \rightarrow p K^{-}\pi^{+}$ and $\rm \Lambda_{c}^{+}\to p K^{0}_{S}$ and respective charge conjugates. The measured differential cross sections as a function of transverse momentum ($p_{\rm T}$) and the $p_{\rm T}$-integrated $\mathrm{\Lambda_{c}^{+}}$ production cross section in pp and in p-Pb collisions are presented. The $\mathrm{\Lambda_{c}^{+}}$ nuclear modification factor ($R_\mathrm{pPb}$), calculated from the cross sections in pp and in p-Pb collisions, is presented and compared with the $R_\mathrm{pPb}$ of D mesons. The $\mathrm {\Lambda_{c}^{+}}/\mathrm {D^0}$ ratio is also presented and compared with the light-flavour baryon-to-meson ratios p$/\pi$ and $\Lambda /\mathrm {K^0_S}$, and measurements from other LHC experiments. The results are compared to predictions from model calculations and Monte Carlo event generators.
Ultrastable complexes for in vivo use: a bifunctional chelator incorporating a cross-bridged macrocycle (2004)

The synthesis, copper(II) complexation and biotin conjugation of a bifunctional chelator incorporating a cross-bridged macrocycle are described.
Conjugative plasmid-encoded toxin–antitoxin system PrpT/PrpA directly controls plasmid copy number (2021)

Toxin-antitoxin (TA) loci were initially identified on conjugative plasmids, and one function of plasmid-encoded TA systems is to stabilize plasmids or increase plasmid competition via postsegregational killing. Here, we discovered that the type II TA system, <i>Pseudoalteromonas rubra</i> plasmid toxin-antitoxin PrpT/PrpA, on a low-copy-number conjugative plasmid, directly controls plasmid replication. Toxin PrpT resembles ParE of plasmid RK2 while antitoxin PrpA (PF03693) shares no similarity with previously characterized antitoxins. Surprisingly, deleting this <i>prpA</i>-<i>prpT</i> operon from the plasmid does not result in plasmid segregational loss, but greatly increases plasmid copy number. Mechanistically, the antitoxin PrpA functions as a negative regulator of plasmid replication, by binding to the iterons in the plasmid origin that inhibits the binding of the replication initiator to the iterons. We also demonstrated that PrpA is produced at a higher level than PrpT to prevent the plasmid from overreplicating, while partial or complete degradation of labile PrpA derepresses plasmid replication. Importantly, the PrpT/PrpA TA system is conserved and is widespread on many conjugative plasmids. Altogether, we discovered a function of a plasmid-encoded TA system that provides new insights into the physiological significance of TA systems.
Light-Induced Self-Written Polymeric Optical Waveguides for Single-Mode Propagation and for Optical Interconnections (2004)

Light-induced self-written (LISW) polymeric optical waveguides were fabricated in a photopolymerizing resin mixture solution using a single-mode optical fiber. In order to realize a straight waveguide core, a pre-UV treatment was performed before core formation. Single-mode propagation of laser light at 1310 nm was realized by appropriately controlling the ratio of the resins in the mixture for the first time. Moreover, optical interconnection between two single-mode fibers was demonstrated based on this technology.
Intelligent Belt Drive Systems in Hybrid Powertrains: a Multipurpose Test Rig (2016)

In traditional engine setups Belt Drive Systems (BDS) are in charge of power transmission from the crankshaft to the accessories. They are complex and critical dynamic mechanisms, involving contact mechanics and vibration phenomena. The hybridization of vehicles has increased the severity of the operating conditions of these systems that have become even more critical. The traditional alternator was substituted by a Belt-Starter Generator (BSG), an electric machine that can power the BDS in particular operating conditions to improve the Internal Combustion Engine (ICE) performance or to allow regenerative braking. The aim of the present work is to describe the design and the main characteristic of a test rig conceived to investigate in laboratory environment on the behaviour of belt drive systems in dynamic conditions. Two permanent magnet electric motors are used to replicate the dynamic behavior of crankshaft and BSG in a realistic, though controlled and repaetable, manner.
Elastic Lattice Enabling Reversible Tetrahedral Li Storage Sites in a High‐Capacity Manganese Oxide Cathode (2022)

The key to breaking through the capacity limitation imposed by intercalation chemistry lies in the ability to harness more active sites that can reversibly accommodate more ions (e.g., Li<sup>+</sup> ) and electrons within a finite space. However, excessive Li-ion insertion into the Li layer of layered cathodes results in fast performance decay due to the huge lattice change and irreversible phase transformation. In this study, an ultrahigh reversible capacity is demonstrated by a layered oxide cathode purely based on manganese. Through a wealth of characterizations, it is clarified that the presence of low-content Li<sub>2</sub> MnO<sub>3</sub> domains not only reduces the amount of irreversible O loss; but also regulates Mn migration in LiMnO<sub>2</sub> domains, enabling elastic lattice with high reversibility for tetrahedral sites Li-ion storage in Li layers. This work utilizes bulk cation disorder to create stable Li-ion-storage tetrahedral sites and an elastic lattice for layered materials, with a reversible capacity of 600 mA h g<sup>-1</sup> , demonstrated in th range 0.6-4.9 V versus Li/Li<sup>+</sup> at 10 mA g<sup>-1</sup> . Admittedly, discharging to 0.6 V might be too low for practical use, but this exploration is still of great importance as it conceptually demonstrates the limit of Li-ions insertion into layered oxide materials.
Photoelectron spectra of the 1,2,5,6-tetramethyl-3,4,7,8-tetramethylene derivatives of tricyclo[3.3.0.02,6]octane and tricyclo[4.2.0.02,5]octane (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotoelectron spectra of the 1,2,5,6-tetramethyl-3,4,7,8-tetramethylene derivatives of tricyclo[3.3.0.02,6]octane and tricyclo[4.2.0.02,5]octaneWeston Thatcher Borden, Stanley D. Young, David C. Frost, Nicholas P. C. Westwood, and William L. JorgensenCite this: J. Org. Chem. 1979, 44, 5, 737–740Publication Date (Print):March 1, 1979Publication History Published online1 May 2002Published inissue 1 March 1979https://pubs.acs.org/doi/10.1021/jo01319a016https://doi.org/10.1021/jo01319a016research-articleACS PublicationsRequest reuse permissionsArticle Views63Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Efficient Locking Techniques for Databases on Modern Hardware. (2012)

Traditional database systems are driven by the assumption that disk I/O is the primary bottleneck, overshadowing all other costs. However, future database systems will be dominated by many-core processors, large main memory, and low-latency semiconductor mass storage. In the increasingly common case that the working data set fits in memory or low-latency storage, new bottlenecks emerge: locking, latching, logging, and critical sections in the buffer manager. Prior work has addressed two of these – latching and logging. This paper addresses locking and proposes new mechanisms optimized for modern hardware. We devised new algorithms and methods to improve all components of database locking, including key range locking, intent locks, detection and recovery from deadlocks, and early lock release. Most of the techniques are easily applicable to other database systems. Experiments with Shore-MT, the transaction processing engine we used as the implementation basis, show throughput improvement by factors of 5 to 50. 1.
1.3‐μm wavelength‐tunable quantum‐dot optical frequency comb generator integrated with absorptive optical attenuator (2011)

Abstract The generation of multiple‐wavelength fine peaks in the 1.3‐μm waveband with wavelength tunability and powercontrollability is successfully demonstrated using a quantum‐dot optical frequency comb laser (QD‐CML) integrated with an absorptive optical attenuator by employing a broadband optical injection seeding technique. High‐quality, high‐density InAs/InGaAs QD optical gain media are fabricated on a GaAs substrate using a sandwiched sub‐nano separator (SSNS) growth technique. A wide wavelength tuning range between 1.274 and 1.302 μm was achieved at a low gain current of 50 mA. In addition, a high extinction ratio of ‐20 dB at a low attenuator voltage (‐2.5 V) was achieved in the fabricated QD‐CML (© 2012 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
Low complexity spatial interpolation for cellular coverage analysis (2014)

During the last decade a lot of effort has been spent on cellular network optimization to improve network capacity and end-user Quality of Service (QoS). Coverage analysis remains as one of the essential topics on which mobile operators still need innovation in terms of performance and cost. Manual coverage analysis is an inefficient and costly task. Radio Environment Maps (REMs) is an efficient coverage analysis solution for present-day cellular networks. REM concept consists of spatially interpolating geo-located measurements to build the whole coverage map using a spatial interpolation technique originating from geo-statistics. Kriging is such a powerful technique which results in high performance in terms of prediction quality. However, this method is costly in terms of computational complexity especially for large datasets: computational complexity of Kriging is O(n <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> ) where n is the number of measurements. This paper proposes the application of a variant of Kriging, Fixed Rank Kriging (FRK), to coverage analysis in order to reduce the computational complexity of the spatial interpolation while keeping an acceptable prediction error.
A protease protection assay for the detection of internalized alpha-synuclein pre-formed fibrils (2020)

ABSTRACT Alpha-synuclein pre-formed fibrils (PFFs) represent a promising model system for the study of cellular processes underlying cell-to-cell transmission of alpha-synuclein proteopathic aggregates. However, the ability to differentiate the fate of internalized PFFs from those which remain in the extracellular environment remains limited due to the propensity for PFFs to adhere to the cell surface. Removal of PFFs requires repeated washing and/or specific quenching of extracellular fluorescent PFF signals. In this paper we present a new method for analyzing the fate of internalized alpha-synuclein. We inserted a tobacco etch virus (TEV) protease cleavage site between alpha-synuclein and green fluorescent protein and subjected cells to brief treatment with TEV protease after incubation with tagged PFFs. As the TEV protease is highly specific, non-toxic, and active under physiological conditions, protection from TEV cleavage can be used to distinguish internalized PFFs from those which remain attached to the cell surface. Using this experimental paradigm, downstream intracellular events can be analyzed via live or fixed cell microscopy as well as by Western blotting. We suggest that this method will be useful for understanding the fate of PFFs after endocytosis under various experimental manipulations.
Phospholipid metabolism during renal regeneration after acute tubular necrosis (1977)

Renal function, structure, and membrane metabolism were studied during regeneration of proximal tubular cells in rats. A reversible syndrome of nonoliguric acute renal failure was induced by the intravenous administration of a low dose of mercuric chloride (1.0 mg Hg/kg). At day 1 there was a marked increase in serum urea nitrogen concentration (SUN), decrease in food intake, and a zone of proximal tubular cell necrosis in the inner cortex. By day 3 low cuboidal epithelial cells were seen, indicating that regeneration had been initiated despite decreased food intake and increasing SUN. Phospholipid synthesis for new membrane formation in regenerating cells was studied by using [14C] choline as a precursor of phosphorylcholine and cytidine diphosphocholine (CDP-choline), which are intermediates in the synthesis of renal choline-containing phospholipid. The rate of [14C]choline incorporation into phospholipids in inner cortical slices was lowest 1 day after mercury administration, then increased constantly for the next 4 days to reach a maximal value 104% above control. The rate declined slowly for the next 11 days and returned to normal by 28 days. The increased rate represented choline phosphoglyceride synthesis, since degradation was unchanged. The entire increment in choline radioactivity in regenerating tissue 2 and 3 days after mercury administration was in phospholipid or CDP-choline, which suggests that the increased number of choline molecules entering the growing cells were trapped in these two forms. The results indicate that renal regeneration is associated with a specific enhancement of the synthesis of choline-containing phospholipids. This anabolic response of the kidney occurs in the presence of systemic catabolism and progressive renal functional insufficiency.
Increased risk of rhinovirus infection in children during the coronavirus disease‐19 pandemic (2021)

Rhinovirus infections should be continuously monitored to understand their increased risk during the COVID-19 pandemic and viral interference with SARS-CoV-2.
Immune-mediated Neuropathy with Epstein-Barr virus-positive T-cell Lymphoproliferative Disease (2015)

A 47-year-old man with Epstein-Barr virus (EBV)-positive T/NK- cell lymphoproliferative disease (EBV-T/NK-LPD) developed acute-onset weakness. A nerve conduction study showed a conduction block in both the proximal and most distal segments. Although the patient's neuropathy transiently responded to intravenous immunoglobulin, it was progressive for at least 25 days until the start of prednisolone (PSL) administration, after which it remarkably improved. The neuropathy further improved after allogeneic bone marrow transplantation (BMT). The present patient's clinical course is not consistent with that of typical Guillain-Barré syndrome. This case suggests that EBV-T/NK-LPD can cause progressive immune-mediated neuropathy as a result of chronic EBV antigen presentation and can be treated with PSL and BMT.
Electrophoretic Deposition of Mesoporous Niobium(V)Oxide Nanoscopic Films (2018)

Nb2O5 is a Li+ intercalation metal oxide that is of current interest for lithium ion battery electrodes. The electrophoretic deposition (ED) of Nb2O5 thin-films from aqueous, NbOx colloidal solutions is reported here. For films ranging in thickness from 38 to 144 nm, the mass loading of Nb2O5 on the electrode is correlated with the coulometry of ED using quartz crystal microbalance gravimetry. Crystalline, phase pure films of orthorhombic, T-Nb2O5, are obtained by postdeposition calcination. These films exhibit unusually high specific capacities for Li+-based energy storage as a consequence of ≈70% porosity. For example, a 60 nm thick film displays a specific capacity, Csp, of 420 mAh/g at 5 A/g and 220 mAh/g at 50 A/g, which can be compared with the theoretical Faradaic capacity of 202 mAh/g. T-Nb2O5 films also have a specific energy density in the range from 770–486 Wh/kg, and a specific power density in the range from 9 to 90 kW/kg. These excellent energy storage metrics are attributed to augmentation of the Faradaic capacity by high double-layer capacities enabled by the mesoporous structure of these films.
Tumor fraction in circulating free DNA as a biomarker of disease dynamics in metastatic prostate cancer. (2018)

195 Background: Quantification of circulating free DNA (cfDNA) has been proposed both as a prognostic biomarker and as a biomarker of response and resistance to therapy. However, dynamics of cfDNA derived from both tumor and non-cancerous tissues through dense longitudinal monitoring over the course of treatment with multiple therapeutic modalities have not been well described. Methods: CfDNA isolated from banked and prospectively collected plasma samples from pts with metastatic castration-resistant prostate cancer (mCRPC) was subject to ultra-low pass (~0.1x coverage) whole genome sequencing (ULP-WGS). The fraction of cfDNA derived from tumor rather than non-cancerous tissues (i.e. the tumor fraction, or TFx) in each sample was estimated using a novel computational tool called ichorCNA, and was correlated with clinical features and response to therapy. Results: 663 plasma samples from 140 pts were included (median 3 samples/pt; range 1-20). TFx was correlated with the number of bone metastases (median TFx = 0.014 with no bone mets, 0.047 with 1-3, 0.190 for 4+), and with the presence of distant visceral mets (p &lt; 0.0001). In multi-variate analysis, TFx was positively correlated with Alk Phos (p = 0.0227) and negatively correlated with Hgb (p &lt; 0.001), but was not correlated with PSA (p = 0.75). All new treatment starts leading to &gt; = 30% PSA decline at &gt; = 6 weeks were associated with a decline in TFx from baseline when baseline TFx was &gt; 7% (median TFx change -92.2%, range -70.3% to -100%); however, TFx in patients being subsequently maintained on secondary hormonal therapy without radiographic progression was quite dynamic. The total yield of cfDNA derived from both tumor and non-cancerous tissues tracked closely with TFx, and did not markedly change with initiation of therapies expected to lead to generalized tissue damage, such as chemotherapy and radiation, over the time scales examined. Conclusions: Decline in TFx is a promising biomarker for initial response to therapy, but subsequent temporary rises in TFx do not necessarily indicate the cessation of clinical benefit from secondary hormonal therapies. Analysis of cfDNA may allow a window into short-term tumor dynamics not easily assayed through other methods.
[Changes in regional cerebral blood flow in nondominant hemisphere during speech task in aphasics.: a PET activation study]. (1995)

To investigate the patients with language disorder and to detect the activated areas in language processing, we measured the changes in the regional cerebral blood flow (CBF) during speech task (¿counting¿ task) using O-15 water PET activation technique in six normal subjects (age 58.3 +/- 8.1), mean +/- SD), ten fluent aphasics (age 60.3 +/- 12.5) and six nonfluent aphasics (age 50.5 +/- 8.3). In ¿counting¿ task, the subjects were instructed to count the number aloud from 1 to 10 and repeat the sequence over and over in the native language (Japanese) at the rate of one number per 2.5 sec. The data were analyzed with stereotactic intersubject averaging analysis for the normal subjects. Apart from it, the regions of interest (ROI) analysis (a circular ROI of 12 mm diameter) was performed in the language-related areas: posteroinferofrontal areas (PIF), posterosuperotemporal area (PST), and Rolandic areas (related to the mouth and lips) were significantly activated bilaterally in the ¿counting¿ task. PIF were activated with a dominance in the left side. In the resting state, rCBF in the left PIF and left PST were activated with a dominance in the left side. In the resting state, rCBF in the left PIF and left PST was reduced in both fluent and nonfluent aphasics. In nonfluent aphasics, the magnitude of activation in the right PIF by ¿counting¿ task was significantly greater than normal subjects and patients with fluent aphasia (ANOVA). It suggests the importance of the right PIF in the simple language processing in the nonfluent aphasia. In the sixteen aphasic patients, the increase in rCBF in the right PST during the ¿counting¿ task was negatively correlated with the score of comprehension (WAB) in the Spearman ranked correlation (p < 0.05). It suggests that, while the activity of the right PST is minimal for the ¿counting¿ in normal subjects, it plays an important and compensatory role in aphasic patients.
A general method for estimating deformation and forces imposed in vivo on bioprosthetic heart valves with flexible annuli: in vitro and animal validation studies. (2001)

This method provides an accurate means of estimating deformation and corresponding forces imposed in vivo on intracardiac prostheses. The results provide information on the dynamic behavior of the mitral valve annulus. Such information should be useful in the design of flexible cardiovascular prostheses.
Microwave-Assisted Parallel Synthesis of a 14-Helical β-Peptide Library (2005)

To facilitate the preparation of beta-peptide libraries in parallel, we have adapted reaction conditions for the solid-phase synthesis of 14-helical beta-peptides for use in a multimode microwave reactor. The low temperature/pressure requirements of microwave-assisted beta-peptide synthesis were found to be compatible with multiwell filter plates composed of polypropylene. Microwave heating of the 96-well plate was sufficiently homogeneous to allow the rapid preparation of a beta-peptide library in acceptable purity.