gebhart/patrepeval huggingface dataset:
Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events (2012)

Lung cancer is a highly heterogeneous disease in terms of both underlying genetic lesions and response to therapeutic treatments. We performed deep whole-genome sequencing and transcriptome sequencing on 19 lung cancer cell lines and three lung tumor/normal pairs. Overall, our data show that cell line models exhibit similar mutation spectra to human tumor samples. Smoker and never-smoker cancer samples exhibit distinguishable patterns of mutations. A number of epigenetic regulators, including KDM6A, ASH1L, SMARCA4, and ATAD2, are frequently altered by mutations or copy number changes. A systematic survey of splice-site mutations identified 106 splice site mutations associated with cancer specific aberrant splicing, including mutations in several known cancer-related genes. RAC1b, an isoform of the RAC1 GTPase that includes one additional exon, was found to be preferentially up-regulated in lung cancer. We further show that its expression is significantly associated with sensitivity to a MAP2K (MEK) inhibitor PD-0325901. Taken together, these data present a comprehensive genomic landscape of a large number of lung cancer samples and further demonstrate that cancer-specific alternative splicing is a widespread phenomenon that has potential utility as therapeutic biomarkers. The detailed characterizations of the lung cancer cell lines also provide genomic context to the vast amount of experimental data gathered for these lines over the decades, and represent highly valuable resources for cancer biology.
Temperature study of high-drive capability buffer for phase change memories (2014)

Phase Change Memory (PCM) is a non-volatile memory technology with wide programming window and continuously improving data retention performance. In order to drive the variable load PCM exhibits, the amplifier providing programming pulses to the cell must be able to accurately control pulse parameters. In this paper, we present a unity gain buffer capable of driving resistive loads varying up to three orders of magnitude. The buffer can replicate voltage pulses of amplitude up to 4.5 V with minimum rise and fall times. The study of the circuit behaviour in high-temperature environments demonstrates its accuracy over a temperature range from -50 °C up to 200 °C, enabling programming of PCM based on innovative materials in applications requiring reliable operation at high temperatures.
Efficient and flexible value sampling (2000)

This paper presents novel sampling-based techniques for collecting statistical profiles of register contents, data values, and other information associated with instructions, such as memory latencies. Values of interest are sampled in response to periodic interrupts. The resulting value profiles can be analyzed by programmers and optimizers to improve the performance of production uniprocessor and multiprocessor systems.Our value sampling system extends the DCPI continuous profiling infrastructure, and inherits many of its desirable properties: our value profiler has low overhead (approximately 10% slowdown); it profiles all the code in the system, including the operating system kernel; and it operates transparently, without requiring any modifications to the profiled code.
Analytical STEM Investigation of the Post-Synthetic Modification (PMS) of Metal-Organic Frameworks (MOFs): Metal- and Ligand-Exchange in UiO-66 (2018)

Post-synthetic modification (PSM) of metal-organic frameworks (MOFs) is a promising route to create novel, and diverse porous nanostructures with tailored functionality for applications from gas storage and separation to catalysis [1]. Recently, post-synthetic exchange (PSE) of metal ions in the secondary-building units (SBUs) of MOFs has been demonstrated in the UiO-66 system, whereby Hf or Ti ions are exchanged for the initial Zr ions in the SBUs, while appearing to retain structural integrity and porosity [2]. Metal ion PSM (transmetalation) has been observed for both solvent-mediated solid-solid reactions and solid-liquid conditions in "robust, inert" MOFs, such as the UiO-66 system [1,3]. This has been proposed as a route to achieve stable MOF structures with specific metal nodes yet to be directly produced using conventional synthesis (e.g. Ti-UiO-66). Despite the interest in PSM, very little is understood about the mechanisms of the exchange process that seem to enable the robust conversion of one metal-containing crystalline MOF nanostructure to an equallystable and -crystalline MOF that contains new metal nodes. Furthermore, though exciting property enhancements have been measured and reported for various transmetalated MOFs, which supports the widelyaccepted concept of metal-exchange in these systems, the true extent of the exchange of metal ions on the nanoscale within a single MOF particle has not been accurately analyzed and quantified.
LED array integrated with Si driving circuits for LED printer printhead (2006)

A 600 dots per inch LED array chip integrated with Si drivers using a three-dimensional epitaxial thin-film bonding has been developed. Performance tests showed high emitted light power (47 µW at an LED current of 1 mA) with smaller variations (±7%), and long lifetime. Test results provide good enough characteristics to use the LED array chip in a high-printing-speed LED printer printhead.
O GeoGebra e a geometria sintética: uma investigação com estudantes brasileiros (2017)

Apresenta-se resultados parciais de uma pesquisa, na qual a segunda autora investigou com alunos do ensino medio brasileiro demonstracoes visuais utilizando o software GeoGebra. Teve-se como objetivo investigar como um grupo de estudantes do ensino medio brasileiro utilizou os principios de geometria sintetica com a ferramenta computacional GeoGebra para realizar argumentacoes na demonstracao da proposicao 5 do livro I de Euclides, a qual afirma que os ângulos da base de um triângulo isosceles sao congruentes. A metodologia, de cunho investigativo, comparou a forma original, segundo Euclides, e a adaptada para a linguagem atual. A analise dos registros dos investigados mostrou que o software foi um facilitador para as argumentacoes dos estudantes enunciarem a proposicao de forma pertinente.
Ferroelectric Pb(Zr,Ti)O-3 thin layers on SrTiO3/GaAs, 26th international conference on Indium Phosphide and related materials (2014)

11-15 Mai 2014
Efficacy of adjuvant chemotherapy for non-small cell lung cancer assessed by metastatic potential associated with ACTN4 (2016)

Although several clinical trials have demonstrated the benefits of platinum-combined adjuvant chemotherapy for resected non-small cell lung cancer (NSCLC), predictive biomarkers for the efficacy of such therapy have not yet been identified. Selection of patients with high metastatic ability in the early stage of non-small cell lung cancer (NSCLC) has the potential to predict clinical benefit of adjuvant chemotherapy (ADJ).In order to develop a predictive biomarker for efficacy of ADJ, we reanalyzed patient data using a public database enrolled by JBR.10, which was a clinical trial to probe the clinical benefits of ADJ in stage-IB/II patients with NSCLC. The patients who were enrolled by JBR.10 were classified into 2 subgroups according to expression of the ACTN4 transcript: ACTN4 positive (ACTN4 (+)) and ACTN4 negative (ACTN4 (-)). In the ACTN4 (+) group, overall survival (OS) was significantly higher in the ADJ subgroup compared with the observation subgroup (OBS), indicating a significant survival benefit of ADJ. However, no difference in OS was found between ADJ and OBS groups in ACTN4 (-). Although ACTN4 expression level did not correlate with the chemosensitivity of cancer cell lines for cytotoxic drugs, the metastatic potential of A549 lung adenocarcinoma cells was significantly reduced by ACTN4 shRNA in in vitro assays and in an animal transplantation model. The clinical and preclinical data suggested that ACTN4 is a potential predictive biomarker for efficacy of ADJ in stage-IB/II patients with NSCLC, by reflecting the metastatic potential of tumor cells.
A graphical programming system with speech input (1974)

An interactive programming system is described where human speech commands and computer graphic input-output facilities are used for the exchange of information between man and machine. The experimental problem solving environment is one of formulating, specifying, debugging and executing (algebraic) procedures interactively on a small processor. The speech recognition system is a real time, syntax directed, limited vocabulary, highly cost effective scheme specifically tailored to this environment. The data transformation operations of the language are verbally specified and the control flow is specified graphically as a two dimensional directed graph. The semantics of the latter structure is independent of the time sequence of its input. An input restricted (conditional input) pseudo-finite state machine model is used for the continuous syntax checking of the input on an atomic token basis and for directing the speech recognizer. The system has been successfully implemented on a small processor at the University of California, Berkeley.
Two-Photon Holographic Stimulation of ReaChR (2016)

Optogenetics provides a unique approach to remotely manipulate brain activity with light. Reaching the degree of spatiotemporal control necessary to dissect the role of individual cells in neuronal networks, some of which reside deep in the brain, requires joint progress in opsin engineering and light sculpting methods. Here we investigate for the first time two-photon stimulation of the red-shifted opsin ReaChR. We use two-photon (2P) holographic illumination to control the activation of individually chosen neurons expressing ReaChR in acute brain slices. We demonstrated reliable action potential generation in ReaChR-expressing neurons and studied holographic 2P-evoked spiking performances depending on illumination power and pulse width using an amplified laser and a standard femtosecond Ti:Sapphire oscillator laser. These findings provide detailed knowledge of ReaChR's behavior under 2P illumination paving the way for achieving in depth remote control of multiple cells with high spatiotemporal resolution deep within scattering tissue.
Myocardial mechanics predict hemodynamic performance during normal function and alcohol-induced dysfunction in rats (1991)

To determine whether mechanical evaluation of muscle tissue removed from the myocardium can be employed as a direct indicator of cardiac contractile performance in situ, isometric and isotonic parameters of muscle mechanics in vitro were correlated with in vivo global functional characteristics of the same heart. Twelve-month-old animals maintained on standard food and water were employed as representative of normal cardiac function. Animals of identical age with left ventricular (LV) dysfunction induced by oral alcohol (30%) ingestion from 4 to 12 mo were utilized to represent depressed cardiac performance. Accordingly, 24 h after the establishment of the hemodynamic profile for a control or experimental heart, the LV posterior papillary muscle was removed from the same heart and examined isometrically and isotonically. Least squares regression analysis was employed to establish a correlation coefficient and P values between various in vitro and in vivo parameters. Hemodynamic measurements were performed under chloral hydrate anesthesia and LV pump performance was evaluated with respect to aortic and ventricular pressures and the rates of rise and decay of the LV pressure trace. Papillary muscles were evaluated with respect to timing parameters of the isometric and isotonic twitch, the first derivative of isometric tension development, and the speed of muscle shortening at increasing physiologic loads. LV peak rate of pressure rise and decay were then correlated with the various isometric and isotonic properties. Myocardial mechanics and hemodynamics revealed depressed function in the papillary muscles and hearts from alcoholic rats. Moreover, significant correlations were found between the LV rate of pressure change (peak +dP/dt and -dP/dt) and both isometric and isotonic twitch measurements.(ABSTRACT TRUNCATED AT 250 WORDS)
Development of a guinea pig cutaneous radiation injury model using low penetrating X-rays (2016)

The guinea pig is an appropriate small animal model for the short-term screening of countermeasures for cutaneous radiation injury (CRI).
Rubber, 8. Synthesis by Polymer Modification (2011)

Abstract The article contains sections titled: 1. Halobutyl Rubber 1.1. Introduction 1.2. Properties, Grades, and Applications 1.3. Basic Chemistry and Production Process 1.3.1. Basic Chemistry 1.3.2. Production 1.4. Chemical Analysis 1.5. Storage and Transportation 1.6. Legal Aspects 1.7. Producers and Production Capacities 1.8. Toxicology and Occupational Health 1.9. New Commercial Development 2. Chloropolyethylene and Chlorosulfonyl Polyethylene 2.1. Chloropolyethylene 2.1.1. Properties, Grades, and Applications 2.1.2. Basic Chemistry and Production Processes 2.2. Chlorosulfonyl Polyethylene 2.2.1. Properties, Grades, and Applications 2.2.2. Basic Chemistry and Production Processes 2.3. Producers and Production Capacities 3. Hydrogenated Nitrile Rubber 3.1. Properties, Grades, and Applications 3.2. Basic Chemistry and Production Processes 3.3. Producers and Production Capacities 4. Polyphosphazenes 4.1. Properties, Grades, and Applications 4.1.1. Properties 4.1.2. Commercial Grades and Applications 4.2. Basic Chemistry and Production Processes 4.3. Producers and Markets
Digital holographic microscopy at fundamental and second harmonic wavelengths (2009)

Optical second harmonic generation, thanks to its coherent nature, is a suitable signal for interferometric measurements, such as digital holography: a well-established imaging technique that allows recovering of the complex diffraction wavefields from which it is possible to extract both amplitude-contrast and quantitative phase images. We believe that application of digital holography to non-linear optical fields might ultimately be the key to phase-related functional imaging. In a first approach, we report here on second harmonic generation digital holographic microscopy, and present its application to (1) discrimination of nanoparticles of different nature — here polystyrene microspheres and barium titanate (BaT iO3) nanoparticles — and to (2) 3D-mapping of a distribution of BaT iO3 nanoparticles.
Green parties and environmental activism (2020)

For this edition on environmental activism and the law, we examined how contemporary green political parties construe their role and relevance when many environmentalists including the Extinction Rebellion (XR) movement are bypassing parliamentary processes by taking to the streets as well as by proposing alternate forms of political engagement such as convening national citizens’ assemblies. This report features interviews conducted in early 2020 with Paul Manly (MP, House of Commons, Green Party of Canada); Chlöe Swarbrick (MP, New Zealand Parliament, Green Party of Aotearoa New Zealand); and Jonathan Bartley (Co-leader of the Green Party of England andWales, and councillor on Lambeth Council, London). Each interviewee responded to the same questions, which are detailed below. The interviews were conducted by Emma Thomas, XR Vancouver (interviewed Paul Manly); Trevor Daya-Winterbottom, FRGS, Associate Professor in Law, University of Waikato, and Deputy Chair of the IUCN Academy of Environmental Law (interviewed Chlöe Swarbrick); and Benjamin J Richardson, Professor of Environmental Law, University of Tasmania (interviewed Jonathan Bartley).
Target-in-the-loop beam control: basic considerations for analysis and wave-front sensing (2005)

Target-in-the-loop (TIL) wave propagation geometry represents perhaps the most challenging case for adaptive optics applications that are related to maximization of irradiance power density on extended remotely located surfaces in the presence of dynamically changing refractive-index inhomogeneities in the propagation medium. We introduce a TIL propagation model that uses a combination of the parabolic equation describing coherent outgoing-wave propagation, and the equation describing evolution of the mutual correlation function (MCF) for the backscattered wave (return wave). The resulting evolution equation for the MCF is further simplified by use of the smooth-refractive-index approximation. This approximation permits derivation of the transport equation for the return-wave brightness function, analyzed here by the method of characteristics (brightness function trajectories). The equations for the brightness function trajectories (ray equations) can be efficiently integrated numerically. We also consider wave-front sensors that perform sensing of speckle-averaged characteristics of the wave-front phase (TIL sensors). Analysis of the wave-front phase reconstructed from Shack-Hartmann TIL sensor measurements shows that an extended target introduces a phase modulation (target-induced phase) that cannot be easily separated from the atmospheric-turbulence-related phase aberrations. We also show that wave-front sensing results depend on the extended target shape, surface roughness, and outgoing-beam intensity distribution on the target surface. For targets with smooth surfaces and nonflat shapes, the target-induced phase can contain aberrations. The presence of target-induced aberrations in the conjugated phase may result in a deterioration of adaptive system performance.
Postpartum ovarian vein thrombosis presenting as ureteral obstruction (2010)

Ovarian vein thrombosis (OVT) is a relatively uncommon but serious postpartum complication. Although infrequent, OVT may progress to involve the inferior vena cava, the renal vein or may cause sepsis and septic pulmonary embolism, all of which are potentially life-threatening. Clinical misdiagnosis is common, and, unfortunately, most affected women undergo laparotomy for possible appendicitis. We present an interesting case of OVT presenting as ureteral obstruction in a postpartum woman who was in her early 20s. Knowledge of this entity and clinical suspicion for its occurrence, in a puerperal patient with fever and abdominal pain not responding to antibiotics, should guide clinicians to appropriate diagnosis and treatment, avoiding misdiagnosis, unnecessary laparotomy and potential complications.
Priapism (2018)

Priapism is a disorder of persistent penile erection unrelated to sexual arousal or desire. This pathologic condition is classified broadly into nonischemic and ischemic forms as well as a recurrent ischemic variant. The recurrent ischemic variant is particularly prevalent in patients with sickle cell disease and may commonly progress to major ischemic episodes. The ischemic form represents a urologic emergency because prolonged episodes have an increased risk of permanent erectile dysfunction. Therefore, timely intervention and treatment are essential. In this chapter, the pathophysiology and current management guidelines and strategies of priapism are reviewed. Further understanding of the molecular pathophysiology of priapism has led to the discovery of new potential targets and may lead to further therapeutic advances in the future. This review contains 6 figures, 6 tables, and 51 references. Key Words: hematology, high-flow priapism, low-flow priapism, nitric oxide, nonischemic priapism, penile prosthesis, recurrent ischemic priapism, shunt, sickle cell disease, sympathomimetic
Low noise, self-referenced all polarization maintaining Ytterbium fiber laser frequency comb: erratum (2020)

We provide a corrected figure of our previous publication [ Opt. Express 25 , 18017 ( 2017 ) 10.1364/OE.25.018017 ].
Formulary and database synchronization (2011)

Automation provides many tools for conducting pharmacy and medication management operations. Examples include order-entry systems, automated medication dispensing cabinets, carousel drug storage units, high-speed bar-code packaging devices, robotic dispensing devices, robotic i.v. preparation devices, bar-code-assisted medication administration (BCMA) systems, and intelligent i.v. infusion pump technology (smart pumps). Accurate drug information is necessary for each of these systems or devices to function effectively, requiring that a formulary and other types of databases (e.g., a database of users, bar codes, or dosage forms) be built and maintained. However, rarely are the systems and devices integrated to provide database continuity. Pharmacy information systems (PISs) and automated distribution systems have gained widespread use over the past 15 years,1 but vendors of these systems have not substantially changed the supporting database structures. Available products do not adequately support a single formulary database capable of flexing attributes between multiple networked pharmacies or hospitals, nor do they allow easy interfacing by “foreign” systems (i.e., solutions from different vendors). Further, in the case of automated medication dispensing cabinets, some vendors have limited the number of devices each server can support, requiring that each health care facility install and maintain a separate server and formulary.
Motion and size estimation of a free moving metallic particle in GIS based on propagation properties of acoustic waves (2004)

Abstract We have investigated the propagation properties of Lamb waves and motion characteristic of free moving metallic particle in a gas‐insulated switchgear (GIS) tank to diagnose the insulation performance of GIS. We have proposed a new identification technique for defect location in GIS based on the time–frequency analysis of the Lamb waves using the Wavelet Transform. In this paper, we measured the acoustic signals excited by a metallic particle colliding with the tank sheath. Furthermore, we measured the moving particles under a high electric field in GIS using a high‐speed video camera. As a result, we examined the relationship between maximum lifting height and the flight time during subsequent impacts of a moving particle. Moreover, we estimated particle size based on the propagation properties of Lamb waves. © 2004 Wiley Periodicals, Inc. Electr Eng Jpn, 150(1): 26–33, 2005; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/eej.20023
Automated closed volume reduction process for apheresis stem cell grafts: From development to clinical implementation (2022)

The effectiveness outcomes of the first Canadian experience in the implementation of a closed semi-automated volume reduction system in the processing of HPC-A products for autologous transplant have met the predetermined acceptance criteria, supporting its use in a stem cell manufacturing laboratory compliant with good manufacturing practice regulations.
Main Radio Interface Related System Procedures (2020)

The use of beamformed signals for initial access is due to the need of scaling the system across the carrier frequencies due to the nature of mandatory beamforming in higher carriers. One of the fundamental elements of beam management is the concept of beam correspondence. This should be seen as a node capability. To enable the plurality of transmission and precoding strategies that are possible to implement with the standard, NR features a flexible and modular channel-state information framework. Radio link failure (RLF) is a procedure where the user equipment (UE) autonomously determines that the radio link is lost. The UE does this by checking whether certain conditions are fulfilled, in which case it declares RLF and performs the associated actions. The basis for radio resource management values are Reference Signal Received Power and Reference Signal Received Quality values.
Mianserina para la mejoría rápida de la acatisia crónica en un paciente esquizofrénico (2004)

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