gebhart/patrepeval huggingface dataset:
Three-Dimensional Quantitative Structure-Activity Relationships of Somatostatin Analogs. 1. Comparative Molecular Field Analysis of Growth Hormone Release-Inhibiting Potencies (1995)

Somatostatin is a hypothalamic hormone that inhibits the release of growth hormone (GH). It has also been shown to inhibit the release of a broad range of hormones including insulin, glucagon, and gastrin. Presently, five different receptor subtypes of somatostatin have been characterized and cloned. Our previous work on the structure-activity relationship of somatostatin and that of many others has generated a large database of analogues with different biological activities and receptor affinities. This present work is an investigation of the growth hormone release-inhibiting potencies of somatostatin analogues by the three-dimensional quantitative structure-activity paradigm, comparative molecular field analysis (CoMFA). A total of 64 analogues were modeled in SYBYL using structural information from two NMR studies. The molecules were aligned by a root-mean-square fit of atoms and field-fit of the steric and electrostatic molecular fields and the resulting databases analyzed by partial least squares analysis with cross-validation to extract the optimum number of components. The analysis was then repeated without cross-validation to give the final QSAR models. Preliminary investigations with the CoMFA models led to the synthesis of a new somatostatin analogue. This compound together with five other newly synthesized compounds not included in the original training sets were used to test the predictive ability of the CoMFA models. Two models with good predictive powers are presented.
Pulse timing optimization of II-IV direct type semiconductor detectors for flat-panel pulsed X-ray imaging (2002)

The rising and falling edges of detected signal pulses have been measured utilizing X-ray ionization of a planar Cd/sub 1-x/Zn/sub x/Te system under different irradiation geometries. The experimental results of this study indicate that the time response of the CdZnTe based X-ray system is suitable for digital pulsed radiographic applications.
High Expression of Ligands for Chemokine Receptor CXCR2 in Alveolar Epithelial Neoplasia Induced by Oncogenic Kras (2006)

CXCL8, a ligand for the chemokine receptor CXCR2, was recently reported to be a transcriptional target of Ras signaling, but its role in Ras-induced tumorigenesis has not been fully defined. Here, we investigated the role of KC and MIP-2, the murine homologues of CXCL8, in Kras(LA1) mice, which develop lung adenocarcinoma owing to somatic activation of the KRAS oncogene. We first investigated biological evidence of CXCR2 ligands in Kras(LA1) mice. Malignant progression of normal alveolar epithelial cells to adenocarcinoma in Kras(LA1) mice was associated with enhanced intralesional vascularity and neutrophilic inflammation, which are hallmarks of chemoattraction by CXCR2 ligands. In in vitro migration assays, supernatants of bronchoalveolar lavage samples from Kras(LA1) mice chemoattracted murine endothelial cells, alveolar inflammatory cells, and the LKR-13 lung adenocarcinoma cell line derived from Kras(LA1) mice, an effect that was abrogated by pretreatment of the cells with a CXCR2-neutralizing antibody. CXCR2 and its ligands were highly expressed in LKR-13 cells and premalignant alveolar lesions in Kras(LA1) mice. Treatment of Kras(LA1) mice with a CXCR2-neutralizing antibody inhibited the progression of premalignant alveolar lesions and induced apoptosis of vascular endothelial cells within alveolar lesions. Whereas the proliferation of LKR-13 cells in vitro was resistant to treatment with the antibody, LKR-13 cells established as syngeneic tumors were sensitive, supporting a role for the tumor microenvironment in the activity of CXCR2. Thus, high expression of CXCR2 ligands may contribute to the expansion of early alveolar neoplastic lesions induced by oncogenic KRAS.
Modeling of Some Dairy Performance Indices on Milk Somatic Cell Count in Holstein Dairy Cows (2019)

This study was conducted to evaluate the direct and the indirect standardized effects of some dairy performance parameters (days dry, lactation length, parity, total milk yield and 305-day milk yield) on the milk Somatic Cell Count (SCC) of Holstein cows throughout modeling of these variables with the path analysis technique. During studying 617 Holstein cows were enrolled in the experiment with the average Days in Milk (DIM) of 157.14 and still in the trial till the end of their lactation length. Milk samples were taken from each cow every three months; then, the fresh milk samples subjected to somatic cell counting via automatic cell counter. Other data of days dry, lactation length, parity, total and actual 305-day milk yields obtained from the dairy farm recording system (Dairycomp). After collection of all data, the data entered to AMOS software program version 24 to build a path model among days dry, lactation length, parity as independent variables and total, 305-day milk yields as intermediate transitional variables and milk SCC as a dependent variable. The study revealed that the SCC was directly affected by lactation length, total and 305-day milk yields, while it indirectly affected with total milk yield. Moreover, the overall standardized effect of the total milk yield on the milk SCC was week as a result of the negative direct effect -0.173 neutralized with another positive indirect one 0.229.
Advanced Cognitive Radio Network (2011)

In recent years, it was realized that Radio Cognitive Systems seems to be a real need in the near future evolution,especially because of the severe spectrum regulations and channel congestion problems. Moreover high data rates become more and more necessary for normal professional needs or at home based users. Cognitive radio systems were first defined in the late of 1990s. The idea is to integrate a new concept of channel environmental sensing, followed by a knowledge based standard learning, which in return helps to identify free channel spectrum slots. These slots can be used by a third party user in a way to take advantage of the unused spectrum.This type of communication provides dynamic opportunistic algorithm for spectrum access. The new concept has to be adaptive and based on a reconfigurable hardware with a real time processing. Such cognitive radio systems can be also used in indoor wireless communications, where more and more wireless peripherals and tools are used in a limited space, and once again data packet congestion is a real problem.

 This book is written by specialists working in the field of telecommunication and signal processing. Various aspects of the radio cognitive systems are discussed with some applications and implementations such as software defined radios.

 The book is composed of seven chapters; as each chapter is written in a self-contained manner, the reader can use the book without any restrictive ordering of the chapters. At the end of the chapters there are valuable references that provide in depth coverage of the application...
Transforming growth factor-beta 1: comparative immunohistochemical localization in human primary and metastatic prostate cancer. (1995)

These findings confirm our previous observation that prostate cancer exhibits enhanced intracellular and extracellular accumulation of TGF-beta 1 relative to normal prostate tissue and benign prostatic hyperplasia. In addition, our study documented a significantly more pronounced accumulation of intracellular TGF-beta 1 in primary prostate cancer with metastasis than in primary tumors without metastasis. Moreover, although the pattern of intracellular TGF-beta 1 staining observed in the primary tumor is maintained in the metastasis, a lack of extracellular accumulation of TGF-beta 1 in the metastatic site was noted. This differential pattern may be biologically important and could conceivably reflect a role for TGF-beta 1 in disease progression.
Synthesis and Evaluation of Compounds That Facilitate the Gastrointestinal Absorption of Heparin (1998)

A family of novel compounds (delivery agents) that promote the gastrointestinal absorption of USP heparin in rats and primates has been discovered. The delivery agents in combination with heparin were administered either orally or intracolonically in an aqueous propylene glycol solution and caused dramatic increases in both plasma heparin concentrations (anti-Factor Xa) and clotting times (APTT). Using one of the most effective delivery agents in this series, an estimated relative bioavailability of 8% can be achieved following oral administration to cynomolgus monkeys. To establish a correlation between the in vivo data and an in vitro parameter, immobilized artificial membrane (IAM) chromatography was performed. Log relative k' values were correlated to the efficiency of oral heparin delivery.
ABCG2‐associated resistance to Hoechst 33342 and topotecan in a murine cell model with constitutive expression of side population characteristics (2009)

Drug resistant tumor "side-populations," enriched in cancer stem cells and identified by reduced accumulation of Hoechst 33342 under ABCG2-mediated efflux, may compromise therapeutic outcome. Side-population cells have predicted resistance to minor groove ligands, including the DNA topoisomerase I poison topotecan. We have used a stable Hoechst 33342-resistant murine L cell system (HoeR415) to study resistance patterns, removing the need for SP isolation before microarray analysis of gene expression and the tracking of cell cycle dynamics and cytotoxicity. The majority of HoeR415 cells displayed a side-population phenotype comparable with that of the side-population resident in the ABCG2 over-expressing A549 lung cancer cell line. Photo-crosslinking showed direct protection against minor groove ligand residence on DNA, driven by ABCG2-mediated efflux and not arising from any binding competition with endogenous polyamines. The covalent minor-groove binding properties of the drug FCE24517 (tallimustine) prevented resistance suggesting a mechanism for overcoming SP-related drug resistance. Hoechst 33342-resistant murine cells showed lower but significant crossresistance to topotecan, again attributable to enhanced ABCG2 expression, enabling cells to evade S-phase arrest. Hoechst 33342/TPT-resistant cells showed limited ancillary gene expression changes that could modify cellular capacity to cope with chronic stress including over-expression of Aldh1a1 and Mgst1, but under-expression of Plk2 and Nnt. There was no evidence to link the putative stem cell marker ALDH1A1 with any augmentation of the TPT resistance phenotype. The study has implications for the patterns of drug resistance arising during tumor repopulation and the basal resistance to minor groove-binding drugs of tumor side-populations.
Ultra-long-range OTDR in single-mode fibres at 1.3 μm (1983)

A single-mode optical time-domain reflectometer (OTDR) operating at a wavelength of 1.3 μm with a dynamic range in excess of 26 dB one way is reported. The equipment incorporates a semiconductor laser source and a new low-noise optical receiver design utilising a PIN diode detector and a transimpedance amplifier.
Transfer of Chirality by the Use of an All Carbon Tether (2011)

Methylketone side chains can be used to direct the creation of one or more chiral centers, including quaternary centers, by exploiting the ability of the radical xanthate transfer process to mediate six-membered ring formation.
A Numerical Approach to Finite Elastic-Plastic Deflections of Circular Plates (1972)

An elastic-plastic analysis of large deflection of axisymmetrically loaded circular plates is presented in this paper. Under the Kirchhoff-Love hypothesis, the incremental theory of plasticity together with the von Mises yield condition and the associated flow rule is adopted, and isotropic workhardening materials as well as elastic-perfectly plastic materials are treated. This is not an inherent limitation of the method. A numerical procedure with the finite difference approximation and the iteration technique is employed for the solution of the derived incremental basic equations of a two-point boundary value problem. Several results for various kinds of boundary condition and some values of plate thickness are given including the solutions of residual stress and strain for the first cycle of a loading-unloading process.
Synthesis of poly(aryl ether-phenylquinoxalines) (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of poly(aryl ether-phenylquinoxalines)James L. Hedrick and Jeff W. LabadieCite this: Macromolecules 1988, 21, 6, 1883–1885Publication Date (Print):June 1, 1988Publication History Published online1 May 2002Published inissue 1 June 1988https://pubs.acs.org/doi/10.1021/ma00184a063https://doi.org/10.1021/ma00184a063research-articleACS PublicationsRequest reuse permissionsArticle Views179Altmetric-Citations68LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Knowledge based signal processing (1982)

The authors discuss knowledge-based signal processing-a term used to describe systems that tightly integrate artificial intelligence (AI) and signal processing which attempts to combine techniques from the two disciplines more imaginatively than in the past. Researchers in the signal processing community are increasingly becoming aware that combining the architecture and methodology of AI with more traditional tools and techniques can lead to significant advances.
Control of p- and n-type carriers by end-group substitution in oligo-p-phenylenevinylene-based organic field-effect transistors (2006)

Organic field-effect transistors (OFETs) consisting of vacuum-evaporated oligo-p-phenylenevinylene derivatives were prepared, and the device characteristics were evaluated. The fabricated OFETs showed typical p-type characteristics for methyl-substituted oligo-p-phenylenevinylene (OPV). A field-effect hole mobility of 0.13cm2V−1s−1 emerged with a threshold voltage of −33V and an on/off ratio of 5.8×105. On the other hand, OFETs showed typical n-type characteristics for trifluoromethyl-substituted OPV. A field-effect electron mobility of 0.013cm2V−1s−1 emerged with a threshold voltage of 45V and an on/off ratio of 4.2×104. The authors have observed clear changes from p-channel to n-channel conductions in OFETs by chemically modifying oligo-p-phenylenevinylenes.
Multicast and Ethernet VPN with Segment Routing Point-to-Multipoint Trees (2020)

A Point-to-Multipoint (P2MP) Tree in a Segment Routing domain
efficiently carries traffic from a Root to a set of Leaves. This
document describes extensions to BGP encodings and procedures for P2MP
trees used in BGP/MPLS IP VPNs and Ethernet VPNs.
Porosity characteristics of ultra-low dielectric insulator films directly patterned by nano-imprint lithography (2008)

Direct patterning of low-dielectric constant (low-k) materials via nanoimprint lithography (NIL) has the potential to
simplify fabrication processes and significantly reduce the manufacturing costs for semiconductor devices. We report
direct imprinting of sub-100 nm features into a high modulus methylsilsesquioxane-based organosilicate glass (OSG)
material. An excellent fidelity of the pattern transfer process is quantified with nm precision using critical dimension
small angle X-ray scattering (CD-SAXS) and specular X-ray reflectivity (SXR). X-ray porosimetry (XRP) and positron
annihilation lifetime spectroscopy (PALS) measurements indicate that imprinting increases the inherent microporosity of
the methylsilsequioxane-based OSG material. When a porogen (pore generating material) is added, imprinting decreases
the population of mesopores associated with the porogen while retaining the enhanced microporosity. The net effect is a
decrease the pore interconnectivity. There is also evidence for a sealing effect that is interpreted as an imprint induced
dense skin at the surface of the porous pattern.
Pulse-amplitude-equalized output from a rational harmonic mode-locked fiber laser (1998)

We report, for the first time to our knowledge, the demonstration of amplitude equalization of high-repetition-rate pulses generated from a rational harmonic mode-locked Er-doped fiber laser. The output pulses are injected into another fiber laser with a nonlinear optical loop mirror. This scheme provides pulse-amplitude equalization up to the ninth rational harmonic mode-locked pulse train.
Engraftment with peripheral blood stem cells collected by large‐volume leukapheresis for patients with lymphoma (1992)

Seven patients with refractory lymphomas underwent marrow reconstitution with peripheral blood stem cells (PBSCs) harvested by large-volume leukapheresis (LVL). PBSCs were collected from all patients more than 1 month after the last cycle of chemotherapy, and no patient received growth factors. The median number of LVL procedures performed per patient was 4.5, with a mean volume of 24.5 L of blood processed per procedure to obtain 7 x 10(8) mononuclear cells per kg. Autologous PBSCs and platelets were frozen at a controlled rate in plasma and 10-percent dimethyl sulfoxide and stored in the vapor phase of liquid nitrogen. This group of patients was compared to a control group (n = 18) who received medullary marrow (MM) transplants for the same diagnoses under the same protocols during the same period. Posttransplant days to white cell engraftment (PBSC = 17, MM = 15.5) were no different. Days to platelet independence were significantly longer in the LVL PBSC group (PBSC = 33, MM = 16; p < 0.05). This pattern of engraftment is typical of patients treated in this manner. Although Day 0 platelet counts (PBSC = 75.5 x 10(9)/L, MM = 85 x 10(9)/L) and total single-donor unit platelet use (PBSC = 8, MM = 9) were no different, Day 1 platelet counts (PBSC = 128 x 10(9)/L, MM = 61.5 x 10(9)/L; p < 0.05) and Day 14 platelet use (PBSC = 5, MM = 8; p < 0.05) were significantly different, because of the transfusion of cryopreserved autologous platelets with PBSCs on Day 0.
Biomimetic Fabrication of 3D Structures by Spontaneous Folding of Tapes (2006)

This paper describes a biomimetic strategy for the fabrication of 3D structures-including an electrically functional light detector-modeled on the folding of biological macromolecules into globular shapes. The process started by fabricating precursors to 3D, millimeter-sized structures using flexible polymer tapes. These tapes were patterned with metal features supporting liquid solder, crimped into strings of 3D corrugations, and attached to flat polymer tapes to generate linear 3D structures. Capillary interactions between droplets of molten solder on adjacent faces of the crimped tapes resulted in folding of the precursors into quasi-3D and truly 3D structures.
The Type 2 Ryanodine Receptor of Neurosecretory PC12 Cells Is Activated by Cyclic ADP-ribose (1996)

Of two neurosecretory PC12 cell clones that respond to NO donors and 8-bromo-cGMP with similar increases in cADP-ribose and that possess molecularly similar Ca2+ stores, only one (clone 16A) expresses the type 2 ryanodine receptor, whereas the other (clone 27) is devoid of ryanodine receptors. In PC12-16A cells, activation of the NO/cGMP pathway induced slow [Ca2+]i responses, sustained by release from Ca2+ stores. In contrast, PC12-27 cells were insensitive to NO donors. Likewise, in PC12-16A cells preincubated with NO donors, Ca2+ stores were partially depleted, as revealed by a test with thapsigargin, whereas those in clone 27 were unchanged. The NO-induced Ca2+ release was increased synergistically by caffeine, and the corresponding store depletion was magnified by ryanodine. The specificity for the NO/cGMP pathway was confirmed by the effects of two blockers of cGMP-dependent protein kinase I, while the role of cADP-ribose was demonstrated by the effects of its antagonist, 8-amino-cADP-ribose, administered to permeabilized cells. These results demonstrate in neurosecretory cells a ryanodine receptor activation pathway similar to that known in sea urchin oocytes. The signaling events described here could be of great physiological importance, especially in the nervous system.
Impact of DFIG-based wind farm on transient stability of single machine infinite bus system (2013)

With the increasing penetration of DFIG-based wind power into the power grid, its effects on synchronous generators in power system become extremely prominent. In the paper, the simplified model of a modified single machine infinite bus (SMIB) system with a DFIG-based wind farm integrated is well studied considering the transient characteristics of the DFIG-based wind farm in the different period of a fault, and the transient stability of the modified SMIB system is analyzed theoretically based on equal-area criterion (EAC) and assessed quantificationlly by using the index of critical clearing time (CCT). The analysis indicates that the performance of synchronous generator can be either improved or deteriorated when DFIG-based wind power are integrated into the system and the stability will decrease as the capacity increases. The effectiveness of the analysis is verified by simulation.
Catalytic Activity of Rare Earth-Promoted SO42-/SnO2in the Oxidative Dehydrogenation of Ethylbenzene (2000)

Abstract Rare earth-promoted (10%) sulfated SnO2 catalysts were prepared by different methods and have been characterized by employing XRD, SEM, Mercury porosimetry, BET surface-area analysis, TG-DTA, and IR spectroscopy. The strength of generated acid sites depends on the preparation method. A thermogravimetric analysis revealed that the removing the sulfate species from the catalyst surface took place at temperatures &amp;gt; 1193 K. The adsorption of butylamine and acetic acid was used to probe the acid-base properties of the catalysts. The catalytic activity of these materials in the oxidative dehydrogenation of ethylbenzene was tested at different temperatures. It was found that rare earth-modified sulfated tin oxide catalysts are more active when compared to the corresponding mixed-oxide systems and sulfated tin oxide. The combined effect of rare earth oxide and the sulfate anion leads to a enhanced oxidation activity. The existence of strong acid sites generated as a result of a sulfate treatment is involved in the activation of ethylbenzene; the addition of rare earth oxides brings about an enhancement of the reaction between the adsorbed oxygen atoms and the adsorbed ethylbenzene.