gebhart/patrepeval huggingface dataset:
Poly(lactide)-block-poly(ε-caprolactone-co-ε-decalactone)-block-poly(lactide) copolymer elastomers (2015)

The midblock composition of poly(lactide)-<italic>block</italic>-poly(ε-caprolactone-<italic>co</italic>-ε-decalactone)-<italic>block</italic>-poly(lactide) is used to tune block polymer melting point, crystallinity, segregation strength and tensile properties.
Isolement et caractérisation de principes actifs d'Abies balsamea et de Cornus canadensis (2015)

Cette thèse présente les travaux réalisés dans le cadre du Doctorat en Science de l'environnement et qui ont pour thèmes l'étude phytochimique du sapin baumier (Abies balsamea) et du quatre-temps (Cornus canadensis). Une revue de littérature étoffée sur le sapin baumier et le quatre-temps recensera d'abord l'ensemble des molécules et bioactivités décrites jusqu'à maintenant pour ces deux plantes.&#13;\nSuivront ensuite les résultats obtenus sur le sapin baumier. La structure de deux tétraterpènes, rapidement déterminée grâce à la spectroscopie de résonance magnétique nucléaire et à la cristallographie par rayon X, sera d'abord présentée. Ensuite, de nouveaux triterpènes de la famille des lanostanes seront décrits. Ces résultats seront complétés par une proposition de structure pour plusieurs autres tétraterpènes qui n'ont pu faire l'objet d'analyse cristallographique.&#13;\nLa dernière partie sera constituée des travaux sur le quatre-temps. L'isolement des principes bioactifs de la plante sera d'abord présenté. Les composés isolés ont été caractérisés par résonance magnétique nucléaire et identifiés comme étant des tannins hydrolysables. Leurs activités antiherpétiques seront ensuite données. Ces résultats seront suivis par la synthèse et l'évaluation de l'activité biologique de composés inspirés de ces principes bioactifs. L'assignation des signaux de résonance magnétique nucléaire de ces molécules sera finalement présentée.&#13;\n&#13;\nThis thesis describes the research carried out as part of the PhD in Environment Science and deals with the phytochemistry of balsam fir (Abies balsamea) and of bunchberry (Cornus&#13;\ncanadensis). A complete literature review covering fir and dogwood will first enumerate the molecules and the bioactivities reported until now for these two plants.&#13;\nWill then follow the results on balsam fir. First, the structure of two tetraterpenes, determined from nuclear magnetic resonance spectroscopy and X-ray crystallography, will be reported. Then, some new triterpenes from the lanostane family will be described. These results will be complemented with a proposal for the structure of several other tetraterpenes that could not be analyzed by crystallography.&#13;\nThe last part will deal with the bunchberry. First, the isolation of bioactive principles of the plant will be&#13;\nreported. The isolated compounds where characterized by nuclear magnetic resonance and identified as hydrolyzable tannins. Their antiherpetic activity will then be demonstrated. These results will be followed by synthesis and evaluation of the bioactivities of molecules derived from those tannins. A complete assignment of the NMR signals for these molecules will ultimately be presented.
A point-based MDP for robust single-lane autonomous driving behavior under uncertainties (2011)

In this paper, a point-based Markov Decision Process (QMDP) algorithm is used for robust single-lane autonomous driving behavior control under uncertainties. Autonomous vehicle decision making is modeled as a Markov Decision Process (MDP), then extended to a QMDP framework. Based on MDP/QMDP, three kinds of uncertainties are taken into account: sensor noise, perception constraints and surrounding vehicles' behavior. In simulation, the QMDP-based reasoning framework makes the autonomous vehicle perform with differing levels of conservativeness corresponding to different perception confidence levels. Road tests also indicate that the proposed algorithm helps the vehicle in avoiding potentially unsafe situations under these uncertainties. In general, the results indicate that the proposed QMDP-based algorithm makes autonomous driving more robust to limited sensing ability and occasional sensor failures.
Cover Feature: Liquid‐Phase Cyclohexene Oxidation with O2 over Spray‐Flame‐Synthesized La1−xSrxCoO3 Perovskite Nanoparticles (Chem. Eur. J. 68/2021) (2021)

The liquid-phase oxidation of cyclohexene was studied over a series of Sr-substituted La1−xSrxCoO3 catalysts of perovskite structure under mild reaction conditions with O2 as oxidant in an autoclave. The substitution of Sr into the perovskite structure led to the formation of catalytically active oxygen species. In-situ ATR IR measurements provided a comprehensive insight into the reaction mechanism under oxidation reaction conditions. More information can be found in the Full Paper by H. Wiggers, B. Peng et al. (DOI: 10.1002/chem.202103381).
The Inhibition of Phosphoenolpyruvate Carboxykinase (Guanosine Triphosphate) Gene Expression by Insulin is Not Mediated by Protein Kinase C* (1987)

The role protein kinase C plays in the regulation of phosphoenolpyruvate carboxykinase (PEPCK) gene expression by insulin and phorbol esters was studied in H4IIE hepatoma cells (ATCC CRL 1548). The combined effects of phorbol 12-myristate 13-acetate (PMA) and insulin on the suppression of mRNA coding for PEPCK (mRNAPEPCK) synthesis were additive. A potent inhibitor of both cyclic nucleotide-dependent protein kinases and protein kinase C, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine, inhibited the cAMP and PMA-mediated regulation of mRNAPEPCK synthesis, but did not affect the action of insulin. Desensitization of the protein kinase C pathway by exposure to PMA for 16 h abolished the subsequent action of the phorbol ester, but did not affect insulin- or cAMP-mediated regulation of PEPCK gene expression. We conclude that insulin suppresses PEPCK gene expression independently from the protein kinase C-mediated pathway used by phorbol esters.
Aging and Disease as Modifiers of Efficacy of Cell Therapy (2008)

Cell therapy is a promising option for treating ischemic diseases and heart failure. Adult stem and progenitor cells from various sources have experimentally been shown to augment the functional recovery after ischemia, and clinical trials have confirmed that autologous cell therapy using bone marrow-derived or circulating blood-derived progenitor cells is safe and provides beneficial effects. However, aging and risk factors for coronary artery disease affect the functional activity of the endogenous stem/progenitor cell pools, thereby at least partially limiting the therapeutic potential of the applied cells. In addition, age and disease affect the tissue environment, in which the cells are infused or injected. The present review article will summarize current evidence for cell impairment during aging and disease but also discuss novel approaches how to reverse the dysfunction of cells or to refresh the target tissue. Pretreatment of cells or the target tissue by small molecules, polymers, growth factors, or a combination thereof may provide useful approaches for enhancement of cell therapy for cardiovascular diseases.
P156 Reduction in colectomy- and health care-related costs in ulcerative colitis patients treated with adalimumab compared with standard therapy (2013)

A delay of 5-ASA therapy >3 months should be avoided to decrease risk for any complication. Prompt diagnosis and therapy should be achieved to prevent development of anemia or extensive disease which were RFs for colectomy.
Detecting conflicts between structure accesses (1988)

Two references to a record structure conflict if they access the same field and at least one modifies the location. Because structures can be connected by pointers, deciding if two statements conflict requires knowledge of the possible aliases for the locations that they access.
Superiority of sequential versus concurrent administration of paclitaxel with etoposide in advanced non-small cell lung cancer: comparison of two Phase II trials. (1998)

Paclitaxel and etoposide are two chemotherapy agents with broad cytotoxic activity and different mechanisms of action and resistance. Preclinical studies of their combined cytotoxicity have yielded conflicting results. We performed two sequential Phase II trials using different sequence schedules of paclitaxel and etoposide as first-line treatment in advanced non-small cell lung cancer (NSCLC). Forty-four patients with stage IIIB or IV NSCLC were included between July 1995 and September 1996. All patients received etoposide at 100 mg/m2, given as an i.v. infusion on days 1, 2, and 3. The first 20 patients (part A) also received paclitaxel at 175 mg/m2 as a 3-h infusion on day 1, immediately prior to etoposide. The subsequent 24 patients (part B) were given the same paclitaxel dose, but on day 4. Grade 3-4 granulocytopenia was seen in 70% of the patients in part A and in 37% of those in part B (P = 0.04). Twenty-five % of the courses in part A and 4% of the courses in part B were associated with granulocyte nadir < or =500/microl (P = 0.00006). No responses were observed in part A, although disease was stabilized in 14 patients (70%). In part B, there were two complete responses and seven partial responses, for an overall response rate of 37.5% (95% confidence interval, 21-58%). In conclusion, toxicity and antitumor activity of the paclitaxel/etoposide combination may be sequence dependent. Our findings suggest that etoposide followed by paclitaxel is well tolerated and has greater activity in NSCLC than concurrent administration.
Investigational Vaccine forEscherichia coliO157: Phase 1 Study of O157 O‐SpecificPolysaccharide‐Pseudomonas aeruginosaRecombinant Exoprotein A Conjugates in Adults (1998)

Escherichia coli O157 causes severe enteritis and the extraintestinal complication hemolytic-uremic syndrome. Serum IgG against the surface polysaccharide antigen, the O-specific polysaccharide of lipopolysaccharide (LPS), may confer protective immunity by lysing the inocula. In a phase 1 clinical study, three investigational vaccines were studied in 87 healthy adults. The vaccines were prepared by covalently binding E. coli O157 O-specific polysaccharide with Pseudomonas aeruginosa recombinant exoprotein A. No significant reactions were reported. Most volunteers (81%) responded with a > 4-fold increase in IgG LPS antibodies 1 week after vaccination; all volunteers responded with a > 4-fold rise at 4 weeks and this level was sustained for 26 weeks after injection. All three vaccines elicited high titers of serum bactericidal activity that roughly correlated with the serum IgG and IgM LPS antibody levels. A phase 2 study in young children is planned.
Search for aW′or Techni-ρDecaying intoWZinppCollisions ats=7  TeV (2012)

A search is performed in pp collisions at sqrt[s]=7 TeV for exotic particles decaying via WZ to final states with electrons and muons. The data sample corresponds to an integrated luminosity of approximately 5 fb(-1). No significant excess is observed in the data above the expected standard model background. Upper bounds at 95% confidence level are set on the production cross section of the W' boson described by the sequential standard model and on the W' WZ coupling. W' bosons with masses below 1143 GeV are excluded. Limits are also set in the context of low-scale technicolor models, under a range of assumptions concerning the model parameters.
Cooperative multisensor system for real-time face detection and tracking in uncontrolled conditions (2005)

The presented work describes an innovative architecture for multi-sensor distributed video surveillance applications. The aim of the system is to track moving objects in outdoor environments with a cooperative strategy exploiting two video cameras. The system also exhibits the capacity of focusing its attention on the faces of detected pedestrians collecting snapshot frames of face images, by segmenting and tracking them over time at different resolution. The system is designed to employ two video cameras in a cooperative client/server structure: the first camera monitors the entire area of interest and detects the moving objects using change detection techniques. The detected objects are tracked over time and their position is indicated on a map representing the monitored area. The objects’ coordinates are sent to the server sensor in order to point its zooming optics towards the moving object. The second camera tracks the objects at high resolution. As well as the client camera, this sensor is calibrated and the position of the object detected on the image plane reference system is translated in its coordinates referred to the same area map. In the map common reference system, data fusion techniques are applied to achieve a more precise and robust estimation of the objects’ track and to perform face detection and tracking. The work novelties and strength reside in the cooperative multi-sensor approach, in the high resolution long distance tracking and in the automatic collection of biometric data such as a person face clip for recognition purposes.
ChemInform Abstract: Design and Synthesis of New Ferroelectric Liquid Crystals. Part 2. Liquid Crystals Containing a Nonracemic 2,3‐Epoxy Alcohol Unit. (1987)

Abstract The phenol (III) is prepared from (I) and the epoxy alcohol (II) via direct Mitsunobu coupling.
Abstract 272: Impaired Arteriogenesis in Cystathionine Gamma-Lyase (CSE) and Endothelial Nitric Oxide Synthase (eNOS) Mutant Mice (2012)

Introduction: Arteriogenesis is an important process involving remodeling of collateral vasculature during chronic or intermittent tissue ischemia. CSE and eNOS are the two principle enzymes for hydrogen sulfide (H 2 S) and Nitric Oxide (NO) generation. Although role of NO during arteriogenesis is partially known, the role of CSE dependent H 2 S production during arteriogenesis remains unknown. Hypothesis/objective: We sought to determine the role of CSE generated H 2 S on arteriogenesis activity of CSE knockout (CSEKO) mice compared to eNOS knock out (eNOSKO) and wild type (WT) mice during hind limb ischemia. Method: Permanent unilateral hind limb ischemia was induced in 12-week-old CSE KO, eNOS KO, and WT mice and studied until day 21. Tissue perfusion was measured using indicator dye blush rates with the SPY Imager system over time along with laser doppler flowmetry. Temporal development of arterial remodeling was also observed using SPY imaging, and vessel number, length and branch morphometry determined over time. Microfil vascular casting was performed to further examine the number of collaterals in ischemic muscles at the end of the study. Histological arteriogenesis was evaluated by vascular smooth muscle actin (SMA) positive vessel density with dual fluorescence staining of anti-CD31 (endothelial positive cell) and anti-α-SMA antibodies. Results: Tissue perfusion was significantly impaired in CSE KO and eNOS KO mice compared to WT mice at different time points throughout the study period. Both CSE KO and eNOS KO mice showed significantly less blush rate than WT mice. SMA positive vessel density was also significantly less in CSE KO and eNOS KO mice than that in WT mice. Conclusion: CSE generated H 2 S and eNOS derived NO play important roles in regulating ischemic arterial remodeling as demonstrated in our studies. The mechanism of impaired arteriogenesis in both mutant mice and the interaction between these two gasotransmitters has yet to be elucidated.
Phase Transfer Pd(O) Catalyzed Polymerization Reactions. 5. Synthesis and Thermal Characterization of 1,2-{4,4′-di[S(-)-2-methylbutyloxy]phenyl}acetylene and 1-(4-n-alkoxyphenyl)-2-{4′-[S(-)-2- methylbutyloxy]phenyl}acetylene Monomers (1991)

Abstract 1,2-{4,4′-Di[S(-)-2-methylbutyloxy]phenyl}acetylene and 1-(4-n-alkoxyphenyl)-2-{4′-[S(-)-2-methyl butyloxyl]phenyl}acetylene monomers were prepared by a one pot phase transfer Pd(O)/Cu(I) catalyzed three step coupling of the appropriate aryl halides with 2-methyl-3-butyn-2-ol. 1,2-{4,4-Di[S(-)-2-methylbutyloxy]phenyl}acetylene is crystalline. The 1-(4-n-alkoxyphenyl)-2-{4′-[S(-)-2-methylbutyl- oxy]phenyl)acetylenes with n=8–10 present enantiotropic cholesteric mesophases, and those with n = 11, 12 present monotropic cholesteric mesophases. The chiral derivative with n = 6 is crystalline with either a second crystalline phase or a highly ordered monotropic smectic mesophase.
Wdpcp, a PCP Protein Required for Ciliogenesis, Regulates Directional Cell Migration and Cell Polarity by Direct Modulation of the Actin Cytoskeleton (2013)

Planar cell polarity (PCP) regulates cell alignment required for collective cell movement during embryonic development. This requires PCP/PCP effector proteins, some of which also play essential roles in ciliogenesis, highlighting the long-standing question of the role of the cilium in PCP. Wdpcp, a PCP effector, was recently shown to regulate both ciliogenesis and collective cell movement, but the underlying mechanism is unknown. Here we show Wdpcp can regulate PCP by direct modulation of the actin cytoskeleton. These studies were made possible by recovery of a Wdpcp mutant mouse model. Wdpcp-deficient mice exhibit phenotypes reminiscent of Bardet-Biedl/Meckel-Gruber ciliopathy syndromes, including cardiac outflow tract and cochlea defects associated with PCP perturbation. We observed Wdpcp is localized to the transition zone, and in Wdpcp-deficient cells, Sept2, Nphp1, and Mks1 were lost from the transition zone, indicating Wdpcp is required for recruitment of proteins essential for ciliogenesis. Wdpcp is also found in the cytoplasm, where it is localized in the actin cytoskeleton and in focal adhesions. Wdpcp interacts with Sept2 and is colocalized with Sept2 in actin filaments, but in Wdpcp-deficient cells, Sept2 was lost from the actin cytoskeleton, suggesting Wdpcp is required for Sept2 recruitment to actin filaments. Significantly, organization of the actin filaments and focal contacts were markedly changed in Wdpcp-deficient cells. This was associated with decreased membrane ruffling, failure to establish cell polarity, and loss of directional cell migration. These results suggest the PCP defects in Wdpcp mutants are not caused by loss of cilia, but by direct disruption of the actin cytoskeleton. Consistent with this, Wdpcp mutant cochlea has normal kinocilia and yet exhibits PCP defects. Together, these findings provide the first evidence, to our knowledge, that a PCP component required for ciliogenesis can directly modulate the actin cytoskeleton to regulate cell polarity and directional cell migration.
Regulation of aldosterone secretion by Cav1.3 (2016)

Aldosterone-producing adenomas (APAs) vary in phenotype and genotype. Zona glomerulosa (ZG)-like APAs frequently have mutations of an L-type calcium channel (LTCC) CaV1.3. Using a novel antagonist of CaV1.3, compound 8, we investigated the role of CaV1.3 on steroidogenesis in the human adrenocortical cell line, H295R, and in primary human adrenal cells. This investigational drug was compared with the common antihypertensive drug nifedipine, which has 4.5-fold selectivity for the vascular LTCC, CaV1.2, over CaV1.3. In H295R cells transfected with wild-type or mutant CaV1.3 channels, the latter produced more aldosterone than wild-type, which was ameliorated by 100 μM of compound 8. In primary adrenal and non-transfected H295R cells, compound 8 decreased aldosterone production similar to high concentration of nifedipine (100 μM). Selective CaV1.3 blockade may offer a novel way of treating primary hyperaldosteronism, which avoids the vascular side effects of CaV1.2-blockade, and provides targeted treatment for ZG-like APAs with mutations of CaV1.3.
Molecular recognition mechanism of peptide chain bound to the tRNALys3anticodon loopin silico (2014)

The mechanism by which proteins recognize and bind the post-transcriptional modifications of RNAs is unknown, yet these interactions play important functions in biology. Atomistic molecular dynamics simulations were performed to examine the folding of the model peptide chain -RVTHHAFLGAHRTVG- and the complex formed by the folded peptide with the native anticodon stem and loop of the human tRNA(Lys3) (hASL(Lys3)) in order to explore the binding mechanism. By analyzing and comparing two folded conformations of this peptide obtained from the folding simulation, we found that the van der Waals (VDW) energy is necessary for the thermal stability of the peptide, and the charge-charge (ELE + EGB) energy is crucial for determining the three-dimensional folded structure of the peptide backbone. Subsequently, two conformations of the peptide were employed to investigate their binding behaviors to hASL(Lys3). The metastable folded peptide was found to bind to hASL(Lys3) much easier than the stable folded peptide in the binding simulations. An energetic analysis reveals that the VDW energy favors the binding, whereas the ELE + EGB energies disfavor the binding. Arginines on the peptide preferentially attract the phosphate backbone via the inter-chain ELE + EGB interaction, significantly contributing to the binding affinity. The hydrophobic phenylalanine interacts with the anticodon loop of hASL(Lys3) via the inter-chain VDW interaction, significantly contributing to the binding specificity.
Alvarez optical components in the THz Regime (2016)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text J. C. Balzer, S. F. Busch, G. Bastian, G. Town, and M. Koch, "Alvarez optical components in the THz Regime," in Conference on Lasers and Electro-Optics, OSA Technical Digest (2016) (Optica Publishing Group, 2016), paper STh1I.2. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
The Mechanism of Racemization of the Hexadentate Complex of Cobalt(III) with Ethylenediaminetetraacetic Acid (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Mechanism of Racemization of the Hexadentate Complex of Cobalt(III) with Ethylenediaminetetraacetic AcidDean W. Cooke, Yong Ae Im, and Daryle H. BuschCite this: Inorg. Chem. 1962, 1, 1, 13–15Publication Date (Print):February 1, 1962Publication History Published online1 May 2002Published inissue 1 February 1962https://pubs.acs.org/doi/10.1021/ic50001a004https://doi.org/10.1021/ic50001a004research-articleACS PublicationsRequest reuse permissionsArticle Views340Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts