gebhart/patrepeval huggingface dataset:
Percutaneous transhepatic access for catheter ablation of cardiac arrhythmias (2013)

Percutaneous transhepatic access is safe and feasible in patients with limited venous access who are undergoing EP study and ablation for a range of cardiac arrhythmias.
Thirst-associated preoptic neurons encode an aversive motivational drive (2017)

Water deprivation produces a drive to seek and consume water. How neural activity creates this motivation remains poorly understood. We used activity-dependent genetic labeling to characterize neurons activated by water deprivation in the hypothalamic median preoptic nucleus (MnPO). Single-cell transcriptional profiling revealed that dehydration-activated MnPO neurons consist of a single excitatory cell type. After optogenetic activation of these neurons, mice drank water and performed an operant lever-pressing task for water reward with rates that scaled with stimulation frequency. This stimulation was aversive, and instrumentally pausing stimulation could reinforce lever-pressing. Activity of these neurons gradually decreased over the course of an operant session. Thus, the activity of dehydration-activated MnPO neurons establishes a scalable, persistent, and aversive internal state that dynamically controls thirst-motivated behavior.
Response to the Comments by Elati et al. in Response to Our Article Examining One of Their Previous Articles (2008)

This reply highlights and discusses what we observe as internal inconsistencies in the data and analysis presented by Elati and coauthors in conjunction with their resolution protocols, as well as inconsistencies between their original manuscript, the associated patent, and the response to our disputing manuscript. We address also their comments concerning their alkylation procedures.
Performance Improvement of Mechanically Beam-Steerable Transmitarray Antennas by Using Offset Unifocal Phase Symmetry (2022)

This communication presents the concept of offset unifocal phase symmetry to improve the performance (gain, gain roll-off, sidelobe level, etc.,) of mechanically beam-steerable transmitarray (TA) antennas. The phase shifts are initially determined from an offset feed source to make the corresponding TA antenna radiate a tilted beam with high gain. The phase shifts are asymmetric and can be broadly divided into dominant and ordinary phase shifts with respect to the offset feed source. By mirroring the dominant phase shifts to make the phase shifts symmetric, it can enable symmetric radiation beams for symmetric offset feed sources and improve phase error. When the offset feed source is moving inward to steer the main beam, the phase error of the phase-shifting surface with respect to the feed source starts to occur, while the electric-field spillover/illumination from the feed source is improved, which can maintain the gains of scanning beams. To verify the validity of the concept, the performance of a beam-steerable TA antenna enabled by the offset unifocal phase symmetry has been simulated and compared with the counterparts of unifocal and bifocal beam-steerable TA antennas. The measured results agree well with the simulated ones, revealing that the beam-steerable TA antenna enabled by the offset unifocal phase symmetry can maintain realized gains of scanning beams, suppress sidelobe levels, and reduce gain roll-off within the beam-scanning coverage. The offset unifocal phase symmetry, in principle, is a generalized approach and applicable to reflectarray antennas to improve the beam-steerable performance as well.
RED: resistance extraction for digital simulation (1987)

This paper describes an extractor designed to produce resistance values for use in digital circuit simulation. REDS avoids resistance extraction on most nets in a design using a simple filter based on the perimeter and area values calculated by the capacitance extractor, allowing it to concentrate on areas where resistance may substantially affect circuit timing. Nets are extracted using a fast square counting algorithm, and simplified before output to remove spurious elements. REDS is designed to work on the Magic layout database.
Investigación en el Laboratorio de Optica de la Universidad de Murcia (LO·UM) (2006)

espanolSe revisan algunas de las contribuciones mas relevantes de las lineas de investigacion que se han llevado a cabo en el Laboratorio de Optica de la Universidad de Murcia en los ultimos anos, junto con una breve mencion a los proyectos actualmente en desarrollo. EnglishWe revise some of the more relevant research contributions carried out at LO·UM during the last years, together with a brief description of the current projects.
Structura parazitismului la șoarecele scurmător in ecosisteme forestiere (2019)

Bank vole (Myodes glareolus) is widely spread silvicolous species, inhabiting in woods, forest clearings, shrub vegetation, at forest edge, near ponds with abundant vegebtation. The parasite fauna is structured of 3 classes, 13 families, 14 genera and 15 species, of which 6.6% belong to class Trematoda, 46.7% to class Cestoda and 46.7% to class Nematoda. The results of the parasitological investigations show a prevalence of Plaghiorchis elegans of 13.8% and an average intensity of 3.8 ex, respectively with Mesocestoides lineatus larvae 14.0%, 1.5 ex, Paranoplocephala omphaloides - 10.3%, 2.7 ex, Rodentolipis straminea - 69.0%, 3.0 ex, Hydatigera taeniaeformis larvae - 10.3%, 1.0 ex, Catenotaenia cricetorum - 10.3%, 2.7 ex, Skrewabinotaenia lobata - 3 ex, Taenia pisiformis - 13.7%, 1.0 ex, Capillaria hepatica - 27.5% and liver infestation is about 50.0% (++), Syphacia stroma - 17.2%, 94 ex, Syphacia obvelata - 24,1%, 84,9 ex, Heligmosomoides polygirus - 10,0%, 5,3 ex, Strongyloides ratti - 6,9%, 23,3 ex, Mastophorus muris - 17,2%, 3 , 6 ex and Trichocephalus muris 17.2%, intensity 3.8 ex. The share of the Trematoda species is 6.6%, in the Cestoda class - 46.7%, and in the Nematoda class - 46.7%. The massive abundance of foxes on large land surfaces, including ecological plasticity with tendency toward synantropization, are the primary factors in the formation, maintenance and spreading of parasitosis outbreaks in natural and anthropic ecosystems. The aim of the research is to study the diversity of parasite fauna in Myodes glareolus from forest ecosystems with specifying the parasite taxonomic structure and determining the degree of infestation.
Experimental results on time-resolved reflectance diffuse optical tomography with fast-gated SPADs (2013)

We present experimental results of time-resolved reflectance diffuse optical tomography performed with fast-gated single-photon avalanche diodes (SPADs) and show an increased imaged depth range for a given acquisition time compared to the non gated mode.
DPIV Measurements of Flow Disturbances in Stented Artery Models: Adverse affects of Compliance Mismatch (2004)

Vascular stents influence the post-procedural hemodynamic environment in ways that may encourage restenosis. Understanding how stents influence flow patterns may lead to more hemodynamically compatible stent designs that alleviate thrombus formation and promote endothelialization. This study employed time-resolved Digital Particle Image Velocimetry (DPIV) to compare the hemodynamic performance of two stents in a compliant vessel. The first stent was a rigid insert, representing an extreme compliance mismatch. The second stent was a commercially available nitinol stent with some flexural characteristics. DPIV showed that compliance mismatch promotes the formation of a ring vortex in the vicinity of the stent. Larger compliance mismatch increased both the size and residence time of the ring vortex, and introduced in-flow stagnation points. These results provide detailed quantitative evidence of the hemodynamic effect of stent mechanical properties. Better understanding of these characteristics will provide valuable information for modifying stent design in order to promote long-term patency.
ChemInform Abstract: Synthesis and in vitro/in vivo Antibacterial Activity of Oxazolidinones Having Thiocarbamate at C‐5 on the A‐Ring and an Amide‐ or Urea‐Substituted [1,2,5]Triazepane or [1,2,5]Oxadiazepane as the C‐Ring. (2014)

Abstract Oxazolidinones (Vb), (VII), and (IX) show 2‐ to 3‐fold greater antibacterial activities against Gram‐positive, Gram‐negative and linezolid‐resistent pathogens than linezolid in a systemic mouse infection model.
Holographic pulse shaping in organic media (2002)

The broad bandwidth of a mode-locked laser pulse can be used to create optical signals of unprecedented time and space complexity. The number of degrees of freedom which can be controlled in a 1-D temporal signal is equal to the ratio of the maximum differential delay encountered by fields transiting the pulse shaper to the size of the minimum temporal feature controlled. This ratio is optimal in reflection holographic pulse shapers.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Do patients with patellofemoral pain syndrome exhibit altered steadiness on dynamic tasks (2006)

Summary: Patellofemoral pain syndrome is a common disorder which can result in alterations in lower limb movement. The aim of this study was to investigate whether patients with PFPS exhibit altered steadiness (measured as standard deviation of acceleration) during two tasks. A 3 dimensional motion analysis system was used to record lower limb acceleration in patients with PFPS and healthy subjects, during single knee bends and squatting. No significant difference in steadiness was found between patients and healthy subjects (p&gt;0.05), however, a significant correlation (p=0.01) was found between knee steadiness and the presence of pain on squatting in patients. This alteration in knee steadiness in PFPS patients may be a compensatory mechanism to protect the patellofemoral joint.
Data from How to Provide the Needed Protection from COVID-19 to Patients with Hematologic Malignancies (2023)

&lt;div&gt;AbstractSummary:&lt;p&gt;Patients with hematologic malignancies are particularly vulnerable to COVID-19 infections, and upon a pooled data analysis of 24 publications, there is evidence that they have suboptimal antibody responses to COVID-19 vaccination and boosters. To provide them the needed additional protection from COVID-19, it is imperative to achieve a 100% full immunization rate in health care workers and adult caretakers, and to foster research to test higher doses and repeated rounds of COVID-19 vaccines and the use of passive immune prophylaxis and therapy.&lt;/p&gt;&lt;/div&gt;
Las plantas medicinales. Ejemplo de nuevo escenario en una clásica aproximación para el descubrimiento del medicamento. (1996)

"El artículo no presenta resumen".
Exploratory Study of the Association of Genetic Factors With Recovery of Adrenal Function in Cushing Disease (2023)

Successful treatment of endogenous Cushing disease (CD) is often followed by a period of adrenal insufficiency (AI). We performed an exploratory study on genetic factors potentially involved in the hypothalamic-pituitary-adrenal (HPA) axis recovery in patients with CD after remission. We identified 90 patients who achieved remission after surgery and had a minimum of 3 months follow-up. Variants in a selected panel of genes that were rare in the general population and predicted as damaging <i>in silico</i> were retrieved from whole exome sequencing analysis. We did not identify any variant with significant correlation with recovery time after adjusting for multiple comparisons. On gene-specific analysis the <i>BAG1</i> gene showed a correlation with shorter duration of postsurgical AI, but both patients with <i>BAG1</i> variants later experienced a recurrence. After excluding patients with recurrence, no statistical association was recorded. To conclude, we did not identify a strong genetic modifier of HPA recovery in this exploratory study.
Dissimilar to Keratinising Epithelia Like the Epidermis (2021)

The FlowCon gives an exact gas organization and stream rate. All the while, the AerationSystem (comprising of GasDivider and AerationCaps) humidifies and conveys the gas stream uniformly to the associated shake carafes, forestalling high vanishing misfortunes and balances out the pH of the media. By controlling the synthetic sythesis of the channel air with the FlowCon, it isn't simply conceivable to enhance CO2 yet in addition to lessen the grouping of oxygen (O2) or even execute hypoxic conditions utilizing nitrogen (N2)*. This control of gas structures takes into account a wide range of utilizations, including undifferentiated cell measures that require physiological oxygen focus at 5% O2 or anaerobic developments in a nitrogen environment.
Notes - Chloroalkyl and Chloroaryl Chloromethylphosphonates (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNotes - Chloroalkyl and Chloroaryl ChloromethylphosphonatesRichard McConnell, Marvin McCall, and H. Coover, Jr.Cite this: J. Org. Chem. 1957, 22, 4, 462–464Publication Date (Print):April 1, 1957Publication History Published online14 April 2003Published inissue 1 April 1957https://pubs.acs.org/doi/10.1021/jo01355a619https://doi.org/10.1021/jo01355a619research-articleACS PublicationsRequest reuse permissionsArticle Views78Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Nagelamides K and L, Dimeric Bromopyrrole Alkaloids from Sponge Agelas Species (2008)

Two new dimeric bromopyrrole alkaloids, nagelamides K (1) and L (2), have been isolated from Okinawan marine sponges Agelas species, and the structures and stereochemistry were elucidated from spectroscopic data. Nagelamide K (1) is a bromopyrrole alkaloid possessing a rare piperidinoiminoimidazolone ring with an aminoimidazole ring and a taurine unit, while nagelamide L (2) is a unique dimeric bromopyrrole alkaloid containing an ester linkage. Nagelamides K (1) and L (2) exhibited antimicrobial activity.
Porting the Clean Object I/O library to Haskell (2001)

. Pure, functional programming languages oer several solutions to construct Graphical User Interfaces (GUIs). In this paper we report on a project in which we port the Clean Object I/O library to Haskell. The Clean Object I/O library uses an explicit environment passing scheme, based on the uniqueness type system of Clean. It supports many standard GUI features such as windows, dialogues, controls, and menus. Applications can have timing behaviour. In addition, there is support for interactive processes and message passing. The standard functional programming language Haskell uses a monadic framework for I/O. We discuss how the Object I/O library can be put in a monadic framework without loosing its essential features. We give an implementation of an essential fragment of the Object I/O library to demonstrate the feasibility. We take especial consideration for the relevant design choices. One particular design choice, how to handle state, results in two versions. 1 Intro...
Die Interaktion von FAT/CD36 mit Cholesterin/Sphingolipidreichen Microdomänen (Lipid Rafts) reguliert den Transport von langkettigen Fettsäuren über die Plasmamembran (2009)

Hintergrund: Ein besseres Verständnis vom molekularen Mechanismus, wie langkettige Fettsäuren in die Zelle aufgenommen werden, ermöglicht möglicherweise neue Ansätze zur Therapie des metabolischen Syndroms und der Fettleber. Die Aufnahme von Fettsäuren wird durch verschiedene Transportvorgänge vermittelt. Neben passiver Diffusion haben Membranproteine Einfluss auf die zelluläre Aufnahme (erleichterter Transport). Wir können zeigen, dass auch Lipid rafts den Fettsäuretransport regulieren.
Whole genome sequencing reveals rare off‐target mutations and considerable inherent genetic or/and somaclonal variations in CRISPR/Cas9‐edited cotton plants (2018)

The CRISPR/Cas9 system has been extensively applied for crop improvement. However, our understanding of Cas9 specificity is very limited in Cas9-edited plants. To identify on- and off-target mutation in an edited crop, we described whole genome sequencing (WGS) of 14 Cas9-edited cotton plants targeted to three genes, and three negative (Ne) control and three wild-type (WT) plants. In total, 4188-6404 unique single-nucleotide polymorphisms (SNPs) and 312-745 insertions/deletions (indels) were detected in 14 Cas9-edited plants compared to WT, negative and cotton reference genome sequences. Since the majority of these variations lack a protospacer-adjacent motif (PAM), we demonstrated that the most variations following Cas9-edited are due either to somaclonal variation or/and pre-existing/inherent variation from maternal plants, but not off-target effects. Of a total of 4413 potential off-target sites (allowing ≤5 mismatches within the 20-bp sgRNA and 3-bp PAM sequences), the WGS data revealed that only four are bona fide off-target indel mutations, validated by Sanger sequencing. Moreover, inherent genetic variation of WT can generate novel off-target sites and destroy PAMs, which suggested great care should be taken to design sgRNA for the minimizing of off-target effect. These findings suggested that CRISPR/Cas9 system is highly specific for cotton plants.
Effective channel length increased due to switching from &#x226A;110&#x226B; to &#x226A;100&#x226B; orientation for PMOS transistors fabricated by 65 nm CMOS technology (2008)

The on-state current of PMOS transistors fabricated on (100) Si substrate can be easily increased by switching from <110> to <100> orientation because of faster hole transport. In addition, PMOS transistors also become slightly ldquolongerrdquo. An experimental estimation of the increase of the effective channel length of the order of nm was made in PMOS transistors fabricated by 65 nm low-power CMOS technology. This can cause a noticeable drop in off current for short PMOS transistors.
Magnetization and domain structure of bccFe81Ni19/Co(001) superlattices (2004)

Dense stripe domains were observed for a ${\mathrm{Fe}}_{81}{\mathrm{Ni}}_{19}/\mathrm{Co}$ superlattice grown on a MgO(100) single crystal substrate using dc magnetron sputtering. The stripe domain period exhibits nonreversible changes with the magnetic field, as determined by magnetic force microscopy. We present a simple theoretical model for this system and calculate the magnetization and domain period as functions of the applied field by minimizing the total energy. For this purpose, an expression for the domain wall energy and wall width for arbitrary angles and one for the magnetostatic energy are derived. The model correctly predicts a decreasing domain period with the increasing applied field. At larger magnetic fields a transition to ``chaotic'' two-dimensional stripe patterns is observed and a qualitative discussion of this phenomenon is given.
Should all postmenopausal patients with hormone receptor-positive breast cancer receive initial therapy with aromatase inhibitors? (2013)

Initial and switching/sequential regimens are equally appropriate adjuvant treatment options for postmenopausal patients with hormone receptor-positive breast cancer. The exact tumour biology which allows for initial AI therapy has not yet been determined with certainty.
Right place, right time (2008)

Recent advances in our understanding of the roles of photoreceptors in light-dependent regulation of plant growth and development have been rapid and significant. Developments have been reported for numerous plant photoreceptor signaling pathways, yet researchers have made the most progress in increasing our comprehension of the roles of phytochrome family members, as well as the intracellular roles of phytochromes and phytochrome-interacting proteins in light-dependent signaling. An understudied, but vitally important, area of phytochrome biology centers on the roles phytochromes play in intercellular and interorgan signaling at the molecular level that results in the coordination of growth responses between distinct tissues and organs. This frontier of research into the spatiotemporal roles of phytochromes, and more generally plant photoreceptors, which is only beginning to be investigated and understood at the molecular genetic level, has a rich history of physiological data.
Wound-Management of Complex Wounds (2009)

PURPOSE STATEMENT: Using new techniques in wound management by negative pressure wound therapy is common, but useful clinical data are required. We report results of a first study using a new NPWT device with variable pressure therapy. LEARNING OBJECTIVES: (i.e., what will the attendee learn after viewing your abstract? Use words that begin with “describe,” identify,” “define,” “list,” “recall,” etc.) 1. describe a new system of NPWT device with variable pressure therapy mode 2. show results of a first open clinical study. PROBLEM: Negative pressure wound therapy has become an acceptable adjunctive therapy in the management of acute and chronic wounds. Application with variable negative pressures (Variable Pressure Therapy; VPT) is a special way of action. We report results of an open, monocentric, prospective, clinical study of 26 patients with chronic, nonhealing wounds using a new NPWT device* with VPT. MATERIALS AND METHODS: From December 2006 to June 2008 an open, monocentric, prospective, clinical study was performed. Documentation was based on both digital documentation system and digital picture documentation with automated measurement for wound size. Data were collected for 26 patients with chronic, nonhealing wounds of different etiologies. Specific endpoints for this study included: easiness of use (pump and dressing) microbial and exudation control readiness for wound healing (granulation) edema reduction patient's quality of life (e.g., pain profile) RESULTS: (n = 26)Table: Variable Pressure ApplicationCONCLUSION: The use of this new variable pressure application technique (VPT) has shown superior clinical results, advantages in handling and in patient's therapeutic comfort (quality of life) and clinical outcome. Special application technique and dressing change periods permit cost-effectiveness.
Nicotine dependence, abuse and craving: dimensionality in an Israeli sample (2011)

Similar to findings from research on other substances, nicotine dependence, abuse and craving criteria appear to derive from a common underlying dimension. The results support alignment of nicotine criteria with those for alcohol and drug use disorders in Diagnostic and Statistical Manual 5th edition.
Underfilling flip chip packages with transfer molding technologies (2005)

This work focuses on the exposed-die molded underfill (MUF) and overmold as underfill (OMUF) technologies for flip chip in the form of a molded matrix array package. A series of mold compounds were selected for this evaluation. MUF and OMUF parts were successfully assembled and subjected to reliability stress tests. All the materials have high MUF and OMUF assembly process yields. The evaluations showed that OMUF has a better reliability performance than that of MUF. Mold corner crack was observed in MUF. This work discusses the relationships between package configurations, assembly processes and material physical properties for high performance MUF/OMUF technologies.