gebhart/patrepeval huggingface dataset:
Cutting Edge: Crucial Role of IL-1 and IL-23 in the Innate IL-17 Response of Peripheral Lymph Node NK1.1− Invariant NKT Cells to Bacteria (2010)

We have shown previously that peripheral lymph node-resident retinoic acid receptor-related orphan receptor γt(+) NK1.1(-) invariant NKT (iNKT) cells produce IL-17A independently of IL-6. In this study, we show that the concomitant presence of IL-1 and IL-23 is crucial to induce a rapid and sustained IL-17A/F and IL-22 response by these cells that requires TCR-CD1d interaction and partly relies on IL-23-mediated upregulation of IL-23R and IL-1R1 expression. We further show that IL-1 and IL-23 produced by pathogen-associated molecular pattern-stimulated dendritic cells induce this response from NK1.1(-) iNKT cells in vitro, involving mainly TLR2/4-signaling pathways. Finally, we found that IL-17A production by these cells occurs very early and transiently in vivo in response to heat-killed bacteria. Overall, our study indicates that peripheral lymph node NK1.1(-) iNKT cells could be a source of innate Th17-related cytokines during bacterial infections and supports the hypothesis that they are able to provide an efficient first line of defense against bacterial invasion.
Elephant: the file system that never forgets (2003)

Modern file systems associate the deletion of a file with the release of the storage associated with that file, and file writes with the irrevocable change of file contents. We propose that this model of file system behavior is a relic of the past, when disk storage was a scarce resource. We believe that the correct model should ensure that all user actions are revocable. Deleting a file should change only the name space and file writes should overwrite no old data. The file system, not the user should control storage allocation using a combination of user specified policies and information gleaned from file-edit histories to determine which old versions of a file to retain and for how long. The paper presents the Elephant file system, which provides users with a new contract: Elephant will automatically retain all important versions of the users' files. Users name previous file versions by combining a traditional pathname with a time when the desired version of a file or directory existed. Elephant manages storage at the granularity of a file or groups of files using user-specified retention policies. This approach contrasts with checkpointing file systems such as Plan-9 AFS, and WAFL, that periodically generate efficient checkpoints of entire file systems and thus restrict retention to be guided by a single policy for all files within that file system. We also report on the Elephant prototype, which is implemented as a new Virtual File System in the FreeBSD kernel.
Correction to Simple Molybdenum(IV) Olefin Complexes of the Type Mo(NR)(X)(Y)(olefin) (2011)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionCorrection to Simple Molybdenum(IV) Olefin Complexes of the Type Mo(NR)(X)(Y)(olefin)Smaranda C. Marinescu, Annie J. King, Richard R. Schrock*, Rojendra Singh, Peter Müller, and Michael K. TakaseCite this: Organometallics 2011, 30, 22, 6338Publication Date (Web):October 26, 2011Publication History Published online26 October 2011Published inissue 28 November 2011https://pubs.acs.org/doi/10.1021/om201013khttps://doi.org/10.1021/om201013kcorrectionACS PublicationsCopyright © 2011 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views624Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (55 KB) Get e-Alertsclose Get e-Alerts
Methanogens and Their Syntrophic Partners Dominate Zones of Enhanced Magnetic Susceptibility at a Petroleum Contaminated Site (2021)

Geophysical investigations documenting enhanced magnetic susceptibility (MS) within the water table fluctuation zone at hydrocarbon contaminated sites suggest that MS can be used as a proxy for investigating microbial mediated iron reduction during intrinsic bioremediation. Here, we investigated the microbial community composition over a 5-year period at a hydrocarbon-contaminated site that exhibited transient elevated MS responses. Our objective was to determine the key microbial populations in zones of elevated MS. We retrieved sediment cores from the petroleum-contaminated site near Bemidji, MN, United States, and performed MS measurements on these cores. We also characterized the microbial community composition by high-throughput 16S rRNA gene amplicon sequencing from samples collected along the complete core length. Our spatial and temporal analysis revealed that the microbial community composition was generally stable throughout the period of investigation. In addition, we observed distinct vertical redox zonations extending from the upper vadose zone into the saturated zone. These distinct redox zonations were concomitant with the dominant microbial metabolic processes as follows: (1) the upper vadose zone was dominated by aerobic microbial populations; (2) the lower vadose zone was dominated by methanotrophic populations, iron reducers and iron oxidizers; (3) the smear zone was dominated by iron reducers; and (4) the free product zone was dominated by syntrophic and methanogenic populations. Although the common notion is that high MS values are caused by high magnetite concentrations that can be biotically formed through the activities of iron-reducing bacteria, here we show that the highest magnetic susceptibilities were measured in the free-phase petroleum zone, where a methanogenic community was predominant. This field study may contribute to the emerging knowledge that methanogens can switch their metabolism from methanogenesis to iron reduction with associated magnetite precipitation in hydrocarbon contaminated sediments. Thus, geophysical methods such as MS may help to identify zones where iron cycling/reduction by methanogens is occurring.
Glucocorticosteroids in Nano-Sterically Stabilized Liposomes Are Efficacious for Elimination of the Acute Symptoms of Experimental Cerebral Malaria (2013)

Cerebral malaria is the most severe complication of Plasmodium falciparum infection, and a leading cause of death in children under the age of five in malaria-endemic areas. We report high therapeutic efficacy of a novel formulation of liposome-encapsulated water-soluble glucocorticoid prodrugs, and in particular β-methasone hemisuccinate (BMS), for treatment of experimental cerebral malaria (ECM), using the murine P. berghei ANKA model. BMS is a novel derivative of the potent steroid β-methasone, and was specially synthesized to enable remote loading into nano-sterically stabilized liposomes (nSSL), to form nSSL-BMS. The novel nano-drug, composed of nSSL remote loaded with BMS, dramatically improves drug efficacy and abolishes the high toxicity seen upon administration of free BMS. nSSL-BMS reduces ECM rates in a dose-dependent manner and creates a survival time-window, enabling administration of an antiplasmodial drug, such as artemisone. Administration of artemisone after treatment with the nSSL-BMS results in complete cure. Treatment with BMS leads to lower levels of cerebral inflammation, demonstrated by changes in cytokines, chemokines, and cell markers, as well as diminished hemorrhage and edema, correlating with reduced clinical score. Administration of the liposomal formulation results in accumulation of BMS in the brains of sick mice but not of healthy mice. This steroidal nano-drug effectively eliminates the adverse effects of the cerebral syndrome even when the treatment is started at late stages of disease, in which disruption of the blood-brain barrier has occurred and mice show clear signs of neurological impairment. Overall, sequential treatment with nSSL-BMS and artemisone may be an efficacious and well-tolerated therapy for prevention of CM, elimination of parasites, and prevention of long-term cognitive damage.
Static and transient characteristics of GaN power HFETs with low‐conducting coating (2014)

Abstract We report on a design of GaN based HFET with a low‐conducting layer (LCL) coating. The LCL coating dramatically improves the electric field uniformity and increases the breakdown voltage. A major advantage is consistent control of the breakdown characteristics, which is expected to dramatically improve yield and reliability. Initial experimental studies demonstrated a three‐fold increase in the breakdown voltage compared with conventional HFETs. The LCL also leads to a much more uniform underlying channel depletion evidenced by a significantly lower HFET channel capacitance in the off state for the HFET based RF switches. This results in a lower loss and higher isolation. Another advantage is a faster transient enabled by LCL, which should improve efficiency and reduce loss for power HFET switches.(© 2014 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
A sub-micron depletion-type photonic modulator in Silicon On Insulator (2005)

We provide detailed analysis of a four terminal p+pnn+ optical modulator integrated into a silicon-on-insulator (SOI) rib waveguide. The proposed depletion device has been designed to approach birefringence free operation. The modulation mechanism is the carrier depletion effect in a pn junction; carrier losses induced are minimised in our design and because we use a depletion device, the device is insensitive to carrier lifetime. The rise time and fall time of the proposed device have both been calculated to be 7 ps for a reverse bias of only 5 volts. A maximum excess loss of 2 dB is predicted for TE and TM due to the presence of p type and n type carriers in the waveguide.
Fully-adaptive Feature Sharing in Multi-Task Networks with Applications in Person Attribute Classification (2016)

Multi-task learning aims to improve generalization performance of multiple prediction tasks by appropriately sharing relevant information across them. In the context of deep neural networks, this idea is often realized by hand-designed network architectures with layers that are shared across tasks and branches that encode task-specific features. However, the space of possible multi-task deep architectures is combinatorially large and often the final architecture is arrived at by manual exploration of this space subject to designer's bias, which can be both error-prone and tedious. In this work, we propose a principled approach for designing compact multi-task deep learning architectures. Our approach starts with a thin network and dynamically widens it in a greedy manner during training using a novel criterion that promotes grouping of similar tasks together. Our Extensive evaluation on person attributes classification tasks involving facial and clothing attributes suggests that the models produced by the proposed method are fast, compact and can closely match or exceed the state-of-the-art accuracy from strong baselines by much more expensive models.
Simulating preemptive scheduling with timing-aware blocks in Simulink (2017)

This paper introduces an extension of the modeling and simulation environment MATLAB/Simulink. It enables control and system engineers to consider software execution times, as well as the effects of scheduling and preemption inside software-in-the-loop (SIL) simulations. To this end, we present the concept of a Simulink block whose execution lasts for a finite amount of simulation time. During this time, the simulation engine continues to update the plant or other blocks with outputs that have already been calculated by the block. Execution time information is assumed to be known (or based on some random distribution). Source-level annotating the control software with target specific timing information enables a finegrained and even a control-flow dependent simulation of the block. We outline the required synchronization with the simulation engine of Simulink. This timing-aware block consumes simulation time in the same sense as a task consumes CPU time on a target. We describe a mechanism to execute a set of such blocks with (potentially cyclic) data dependencies with a static priority scheduler inside Simulink, including support for preemption. The presented approach permits a development process, where a typical time invariant and platform agnostic model is incrementally transformed into a platform-specific one that makes the simulation more realistic.
Aminoglycoside Resistance Genes aph(2")-Ib and aac(6′)-Im Detected Together in Strains of both Escherichia coli and Enterococcus faecium (2001)

Escherichia coli SCH92111602 expresses an aminoglycoside resistance profile similar to that conferred by the aac(6')-Ie-aph(2")-Ia gene found in gram-positive cocci and was found to contain the aminoglycoside resistance genes aph(2")-Ib and aac(6')-Im (only 44 nucleotides apart). aph(2")-Ib had been reported previously in Enterococcus faecium SF11770. aac(6')-Im had not been detected previously in enterococci and was found to be present also 44 nucleotides downstream from aph(2")-Ib in E. faecium SF11770. aph(2")-Ib and aac(6')-Im are separate open reading frames, each with its own putative ribosome binding site, whereas aac(6')-Ie-aph(2")-Ia appears to be a fusion of two genes with just one start and one stop codon. The deduced AAC(6')-Im protein exhibits 56% identity and 80% similarity to the AAC(6')-Ie domain of the bifunctional enzyme AAC(6')-APH(2"). Our results document the existence of a member of the aph(2") family of genes in gram-negative bacteria and provide evidence suggesting the horizontal transfer of aph(2")-Ib and aac(6')-Im as a unit between gram-positive and gram-negative bacteria.
A scanning tunneling microscope with a wide sampling range (1990)

Construction of a simple scanning tunneling microscope (STM) is described. This STM is suitable for atmospheric, controlled atmosphere, and high vacuum (but not UHV) work. This STM is especially well suited for determining surface topography on the 0.1 nm scale when images must be obtained over a wide sampling region (mm). Interchangeable piezo heads allow the STM to be used either for atomic resolution or for large (800×800 nm) area scans. Atomic resolution pictures of the graphite surface demonstrate that this design is suitable for use with structures smaller than 0.1 nm. An image of a thin film of Au, deposited on pyrex, is also presented.
Access overlays (2011)

Many touch screens remain inaccessible to blind users, and those approaches to providing access that do exist offer minimal support for interacting with large touch screens or spatial data. In this paper, we introduce a set of three software-based access overlays intended to improve the accessibility of large touch screen interfaces, specifically interactive tabletops. Our access overlays are called edge projection, neighborhood browsing, and touch-and-speak. In a user study, 14 blind users compared access overlays to an implementation of Apple's VoiceOver screen reader. Our results show that two of our techniques were faster than VoiceOver, that participants correctly answered more questions about the screen's layout using our techniques, and that participants overwhelmingly preferred our techniques. We developed several applications demonstrating the use of access overlays, including an accessible map kiosk and an accessible board game.
Self-Assembly of Fluorinated Boronic Esters and 4,4′-Bipyridine into 2:1 N→B Adducts and Inclusion of Aromatic Guest Molecules in the Solid State: Application for the Separation of o,m,p-Xylene (2018)

A series of 2:1 fluorinated arylboronic ester adducts with 4,4′-bipyridine sustained by N→B dative bonds have been synthesized. The degree of fluorination in the arylboronic esters derived from catechol is shown to modulate the molecular conformation of the coordinated boronic ester moieties and the intermolecular interactions by means of C–H···F and F···F contacts that sustain the crystal lattices. The adduct derived from the catechol ester of 2,4-difluorophenylboronic acid was chosen to examine the formation of inclusion complexes with a large number of aromatic guests, affording solvates, cocrystals, and a cocrystal solvate. Six different crystal structure types with 1:1, 1:2, and 1:2:2 N→B adduct–guest ratios were observed, whose supramolecular organization is strongly influenced by the formation of sandwich-type complexes between the host and guest molecules. The host–guest interactions involve π···π interactions with the bipyridine linkers and additional contacts with the catecholate and B-arylF substituents, indicating a large flexibility of the N→B adducts to adapt to the guest stereochemistry. The versatility of the crystallization system was employed to isolate o-xylene from an equimolar mixture of o-, m-, and p-xylene.
RadarViewer : Visualizing the dynamics of multivariate data (2020)

This showcase presents a visual approach based on clustering and superimposing to construct a high-level overview of sequential event data while balancing the amount of information and the cardinality in it. We also implement an interactive prototype, called RadarViewer , that allows domain analysts to simultaneously analyze sequence clustering, extract useful distribution patterns, drill multiple levels-of-detail to accelerate the analysis. The RadarViewer is demonstrated through case studies with real-world temporal datasets of different sizes.
INFLUENCE OF OPTICAL FILTER EFFECT ON THE INCIDENT PHOTON TO CURRENT EFFICIENCY OF HETEROJUNCTION ORGANIC PHOTOVOLTAIC DEVICES (2009)

The origin of incident photon to current efficiency (IPCE) of single heterojunction organic photovoltaic devices consisting of copper phthalocyanine (p‐type) and perylene (n‐type) layers has been investigated by means of optical filter effect phenomenon. The p/n type and n/p structure devices were fabricated by sandwiching p/n and n/p layers between two metal ohmic contacts, respectively. Under illumination of white light, the optical filter effect phenomenon was clearly observed, i.e. the contribution of n layer to the exciton generation was observed at 535 nm for the p/n devices, while for the n/p devices the contribution of p layer was stronger, at 635 nm and 700 nm, than that of the n layer. The symbatic like of IPCE action spectra indicate that the exciton dissociation effectively takes place at the p/n interface.
Use of AFLP and RAPD molecular genetic markers and cytogenetic analysis to explore relationships among taxa of the Patagonian Bromus setifolius complex (2009)

Bromus setifolius var. pictus (Hook) Skottsb., B. setifolius var. setifolius Presl. and B.setifolius var. brevifolius Ness are three native Patagonian taxa in the section Pnigma Dumort of the genus Bromus L. AFLP and RAPD analysis, in conjunction with genetic distance measurements and statistical techniques, revealed variation within this group and indicated that B. setifolius var. brevifolius was closely related to B. setifolius var. pictus, with both taxa being more distantly related to B. setifolius var. setifolius. Cytogenetic analysis confirmed the chromosomal number of B. setifolius var. pictus (2n = 70) and B. setifolius var. setifolius (2n = 28) and showed for the first time that B. setifolius var. brevifolius had 2n = 70. The combination of molecular genetic and cytogenetic evidence supported a species status for two of the three taxa and suggested hypotheses for the evolutionary origin of these complex taxa. Species status was also indicated for B. setifolius var. setifolius. Based on these findings, we suggest that B. setifolius var. pictus be referred to as B. pictus Hook var. pictus, and B. setifolius var brevifolius as B. pictus Hook var brevifolius. The correlation between AFLP diversity and variation in ecological parameters suggested that this marker system could be used to assess breeding progress and to monitor the domestication of Patagonian Bromus species for agronomic use.
Protecting biodegradable coatings releasing antimicrobial agents (2007)

Abstract This article describes the synthesis and in vitro analysis of poly(ester anhydride) antimicrobial protection coatings. Poly(ester anhydride)s composed of ricinoleic acid, sebacic acid, terephthalic acid, and isophthalic acid were used in this study. The polymers were compatible with various fillers commonly used in paint preparation. The in vitro experiments showed that the polymers are able to release diuron, an antimicrobial agent, for months. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci 2007
High-Performance Logic-on-Memory Monolithic 3-D IC Designs for Arm Cortex-A Processors (2021)

Monolithic 3-D IC (M3-D) is a promising solution to improve the performance and energy-efficiency of modern processors. But, designers are faced with challenges in design tools and methodologies, especially for power and thermal verifications. We developed a new physical design flow that optimally places and routes cache modules in one tier and logic gates in the other. Our tool also builds high-quality clock and power delivery networks targeting logic-on-memory M3-D designs. Finally, we developed a sign-off analysis tool flow to evaluate power, performance, area (PPA), thermal, and voltage-drop quality for given M3-D designs. Using our complete register transfer level (RTL)-to-Graphic Design System (GDS) tool flow, we designed commercial quality 2-D and M3-D implementation of Arm Cortex-A7 and Cortex-A53 processors in a commercial 28-nm technology. Experimental results show that our 3-D processors offer 20% (A7) and 21% (A53) performance gain, compared with their 2-D commercial counterparts. The voltage-drop degradation of our 3-D Cortex-A7 and Cortex-A53 processors is less than 3% of the supply voltage, while temperature increase is 10.71 °C and 13.04 °C, respectively.
Lower Hybrid Heating of an Electron-Cyclotron-Resonance Plasma in a Canted Magnetic Mirror (1976)

Plasma heating at the lower hybrid resonance was studied experimentally in a canted magnetic mirror in order to determine the effects of magnetic field curvature on heating efficiency. Heating occurred mainly on what would be the "outside" of an equivalent torus, peaking near the hybrid resonant layer. The best conditions for heating were seen to be a relatively flat density profile of magnitude slightly below that where hybrid resonance would be expected. The density profile was seen to move "outward" as cant angle was increased, while the hybrid layers were seen to move oppositely, toward what would be the inside of the torus. No significant deleterious effects on the efficiency of the lower hybrid resonant heating (LHRH) were observed as the canting was changed.