gebhart/patrepeval huggingface dataset:
1459: Activity of Different Phospholipids in Attenuating Hyperactivity in Bladder Irritation (2007)

You have accessJournal of UrologyModerated Poster 45, Tuesday, May 22, 2007, 1:00 - 3:00 pm1 Apr 20071459: Activity of Different Phospholipids in Attenuating Hyperactivity in Bladder Irritation Pradeep Tyagi, Michael B. Chancellor, Naoki Yoshimura, Leaf Huang, and Jonathan Kaufmann Pradeep TyagiPradeep Tyagi More articles by this author , Michael B. ChancellorMichael B. Chancellor More articles by this author , Naoki YoshimuraNaoki Yoshimura More articles by this author , Leaf HuangLeaf Huang More articles by this author , and Jonathan KaufmannJonathan Kaufmann More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)31660-4AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "1459: Activity of Different Phospholipids in Attenuating Hyperactivity in Bladder Irritation." The Journal of Urology, 177(4S), pp. 481–482 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 177Issue 4SApril 2007Page: 481-482 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Pradeep Tyagi More articles by this author Michael B. Chancellor More articles by this author Naoki Yoshimura More articles by this author Leaf Huang More articles by this author Jonathan Kaufmann More articles by this author Expand All Advertisement PDF downloadLoading ...
A Whole Virus Pandemic Influenza H1N1 Vaccine Is Highly Immunogenic and Protective in Active Immunization and Passive Protection Mouse Models (2010)

The recent emergence and rapid spread of a novel swine-derived H1N1 influenza virus has resulted in the first influenza pandemic of this century. Monovalent vaccines have undergone preclinical and clinical development prior to initiation of mass immunization campaigns. We have carried out a series of immunogenicity and protection studies following active immunization of mice, which indicate that a whole virus, nonadjuvanted vaccine is immunogenic at low doses and protects against live virus challenge. The immunogenicity in this model was comparable to that of a whole virus H5N1 vaccine, which had previously been demonstrated to induce high levels of seroprotection in clinical studies. The efficacy of the H1N1 pandemic vaccine in protecting against live virus challenge was also seen to be equivalent to that of the H5N1 vaccine. The protective efficacy of the H1N1 vaccine was also confirmed using a severe combined immunodeficient (SCID) mouse model. It was demonstrated that mouse and guinea pig immune sera elicited following active H1N1 vaccination resulted in 100% protection of SCID mice following passive transfer of immune sera and lethal challenge. The immune responses to a whole virus pandemic H1N1 and a split seasonal H1N1 vaccine were also compared in this study. It was demonstrated that the whole virus vaccine induced a balanced Th-1 and Th-2 response in mice, whereas the split vaccine induced mainly a Th-2 response and only minimal levels of Th-1 responses. These data supported the initiation of clinical studies with the same low doses of whole virus vaccine that had previously been demonstrated to be immunogenic in clinical studies with a whole virus H5N1 vaccine.
FLUORESCENCE STUDIES ON CHLOROPLAST COUPLING FACTOR (1976)

A protein known as coupling factor (CF) located on the thylakoid membrane surface produces ATP from ADP and P. when chloroplasts are 1 illuminated.This process represents the final stage in energy transduction in higher plants whereby absorbed light is converted into the high energy phosphate bond of ATP.It is generally accepted that the major stages in this process include the absorption of light, a primary charge separation leading to a series of electron transport reactions in the membrane, the production of' a transmembrane proton electrochemical gradient and the coupling of this grudient to the synthesis of ATP in the active site of CF. 'l'o gain insight into the molecular details of this coupling process, we have investigated the structure and dynruni<"s of CF using f1 uorencence lnhelinr; techniques.In addition, we have constructed a novel fluorescence lifetime /'' \_I .. -1-' .,.) and the question is far from resolved.Pseudocyclic photophosphorylation occurs when molecular oxygen serves as the terminal electron acceptor in a non-cyclic electron transport.Oxygen and electron acceptors must be present for this process to occur (Arnon, 68; Epel and Neumann, 73).It was recently observed that 0.
Effects of varying subatmospheric pressure on stationary plasma arc welds (1991)

An experimental study was performed examining the variation of penetration, fluid behavior, heat-affected zone and arc in plasma arc welding (PAW) with respect to subatmospheric ambient pressure. The results reveal nonlinear variation of keyhole size, time of penetration, and size of the heat-affected zone with pressure. In a restricted range of pressure, dynamic components of fluid flow directed out of the molten pool appear and have a profound effect on keyhole formation. The generated plasma arc is observed to decrease in intensity with decreasing pressure, resulting in a reduction of penetration at lower pressures.
Purification, Assay and Kinetic Features of HIV-1 Proteinase (1990)

1) The aspartic proteinase of the human immunodeficiency virus type 1 (HIV-1) was purified from cultures of recombinant E. coli. The enzyme preparation is homogeneous as judged by SDS-polyacrylamide gel electrophoresis and isoelectric focusing. 2) A rapid assay procedure for the proteinase was established which makes use of the cleavage of a radiolabeled decapeptide and the separation of substrate and labeled product by ion-exchange resin. 3) Activity of the enzyme is optimal at an ionic strength of 2.5-3.5M; also, the inhibitor pepstatin is a more potent inhibitor at higher ionic strength. This can be attributed to a tighter binding of both substrate and inhibitor in high-salt buffer. 4) The Km value of the decapeptide substrate is independent of the pH in the range of 3.5-7.5, while kcat shows a bell-shaped curve with a maximum at pH 5.2. The shape of the curve can be attributed to pKa values of 4.2 and 6.2 of groups on the enzyme. Pepstatin inhibition is optimal below pH 5.5, but becomes weak above pH 6.
Synthetic host defense peptide IDR-1002 reduces inflammation in Pseudomonas aeruginosa lung infection (2017)

Pseudomonas aeruginosa is a frequent cause of lung infections, particularly in chronic infections in cystic fibrosis patients. However, treatment is challenging due to P. aeruginosa evasion of the host immune system and the rise of antibiotic resistant strains. Host defense peptides (HDPs) and synthetic derivatives called innate defense regulators (IDRs) have shown promise in several infection models as an alternative to antibiotic treatment. Here we tested peptide IDR-1002 against P. aeruginosa in vitro and in vivo. Treatment of bronchial epithelial cells and macrophages with IDR-1002 or in combination with live P. aeruginosa or its LPS led to the reduction of agonist-induced cytokines and chemokines and limited cell killing by live P. aeruginosa. In an in vivo model using P. aeruginosa combined with alginate to mimic a chronic model, IDR-1002 did not reduce the bacterial burden in the lungs, but IDR-1002 mice showed a significant decrease in IL-6 in the lungs and in gross pathology of infection, while histology revealed that IDR-1002 treated mice had reduced alveolar macrophage infiltration around the site of infection and reduced inflammation. Overall, these results indicate that IDR-1002 has promise for combating P. aeruginosa lung infections and their resulting inflammation.
Image Reconstruction in Spectrally Resolved 3D Bioluminescence Tomography using the Adjoint Theorem (2008)

Spectrally-resolved BioLuminescence optical Tomography (sBLT) is used to recover images of Luciferase activity within a 3D model using multi-wavelength emission data from internal bioluminescence sources. The Adjoint theorem for 3D image reconstruction is presented and validated using experimental data with a complete computation time of 5 minutes.
A Novel Human Artificial Chromosome Vector Provides Effective Cell Lineage–Specific Transgene Expression in Human Mesenchymal Stem Cells (2005)

Mesenchymal stem cells (MSCs) hold promise for use in adult stem cell-mediated gene therapy. One of the major aims of stem cell-mediated gene therapy is to develop vectors that will allow appropriate levels of expression of therapeutic genes along differentiation under physiological regulation of the specialized cells. Human artificial chromosomes (HACs) are stably maintained as independent chromosomes in host cells and should be free from potential insertional mutagenesis problems of conventional transgenes. Therefore, HACs have been proposed as alternative implements to cell-mediated gene therapy. Previously, we constructed a novel HAC, termed 21 Deltapq HAC, with a loxP site in which circular DNA can be reproducibly inserted by the Cre/loxP system. We here assessed the feasibility of lineage-specific transgene expression by the 21Deltapq HAC vector using an in vitro differentiation system with an MSC cell line, hiMSCs, which has potential for osteogenic, chondrogenic, and adipogenic differentiation. An enhanced green fluorescent protein (EGFP) gene driven by a promoter for osteogenic lineage-specific osteopontin (OPN) gene was inserted onto the 21 Deltapq HAC and then transferred into hiMSC. The expression cassette was flanked by the chicken HS4 insulators to block promoter interference from adjacent drug-resistant genes. The EGFP gene was specifically expressed in the hiMSC that differentiated into osteocytes in coordination with the transcription of endogenous OPN gene but was not expressed after adipogenic differentiation induction or in noninduction culture. These results suggest that use of the HAC vector is suitable for regulated expression of transgenes in stem cell-mediated gene therapy.
Ensemble Gaussian Processes for Online Learning Over Graphs With Adaptivity and Scalability (2021)

In the past decade, semi-supervised learning (SSL) over graphs has gained popularity due to its importance in a gamut of network science applications. While most of existing SSL methods provide only point estimates of the targeted variables, the present work capitalizes on Gaussian processes (GPs) to offer a Bayesian SSL approach over graphs with uncertainty quantification, a key attribute especially in safety-critical domains. To accommodate also delay-sensitive scenarios, an incremental learning mode is considered, where prediction of the desired value of a new node per iteration is followed by processing the corresponding nodal observation. Taking the per-node one-hop connectivity vector as the input, the prediction of targeted nodal value is enabled by leveraging an ensemble (E) of GP experts, whose weights are updated in a data-adaptive fashion. In the resultant GRaph-ADpative EGP framework, random feature-based kernel approximation is employed to not only allow learning with scalability, but also preserve privacy by relying on an encrypted version of each node’s connectivity. Besides the one-hop connectivity vector, the novel GradEGP accommodates each node’s egonet features as alternative inputs. On the analytical side, to assess the performance of GradEGP in the adversarial setting where the generative assumptions are violated, <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">regret analysis</i> measures the cumulative online losses relative to their counterparts of a benchmark learner with batch data in hindsight. Tests conducted on real and synthetic datasets demonstrate the effectiveness of the advocated method.
The Graphics, Visualization, and Usability Center Brochure (1991)

Graphics, Visualization, and Usability (GVU) is an interdisciplinary area which draws its intellectual foundations from Computer Science, Psychology, Industrial and Systems Engineering, and Computer Engineering, and which has application to any use of computers to graphically convey information to users. Typical applications are computer aided design, scientific and business data visualization, multimedia, computer-supported cooperative work, computer-based teaching, image understanding, medical imaging, and user interface design.&#13;\n&#13;\n&#13;\nThe GVU Center has three missions: education, service, and research. In our educational role, we teach the principles and methods of computer graphics, visualization, and usability to members of the academic community ranging from undergraduate students to graduate students and faculty. Center members teach dozens of courses and seminars among the wide offering of relevant courses listed in Section F. A set of continuing education short courses (Section G) are provided to assist practitioners to stay abreast of current developments. Our service mission is carried out through the Scientific Visualization Lab, a joint undertaking with Information Technology (the campus-wide computer service), to provide state of the art computer graphics hardware and software capabilities to the entire Georgia Tech Community. Over 150 faculty, graduate students and staff use the visualization lab's facilities. Our research, described in Section B, spans the areas of realistic imagery, computer-supported collaborative work, algorithm animation, medical imaging, image understanding, scientific data visualization, animation, user interface software, usability, adaptive user interfaces, multimedia, stereo graphics, virtual environments, image quality, and expert systems in graphics and user interfaces. The twenty faculty and staff who are actively developing the lab's programs are drawn from Psychology, Mechanical Engineering, Office of Interdisciplinary Programs, Physics, Mathematics, Information Technology, and the College of Computing. An active seminar series and brown-bag lunches brings us together every week to discuss current research topics.&#13;\n&#13;\n&#13;\nBy integrating these three missions together in a single unit, the Center is developing a highly interactive and collaborative environment where researchers unfamiliar with computer graphics can come for help in integrating scientific visualization into their research work, graphics experts and graduate students can share thier knowledge with one another and find new and interesting problems on which to work, and students can learn in a melting pot of closely-related ideas and collaborations between researchers from multiple disciplines. This intellectually-stimulating environment, complemented by over 40 workstations and other pieces of equipment and over 3000 square feet of newly-renovated lab space, provides a paradigm for the use of interactive computer graphics systems which will be necessary for engineering and scientific research in the 21st century.
Bridging the Gap between Spatial and Spectral Domains: A Unified Framework for Graph Neural Networks (2021)

Deep learning's performance has been extensively recognized recently. Graph neural networks (GNNs) are designed to deal with graph-structural data that classical deep learning does not easily manage. Since most GNNs were created using distinct theories, direct comparisons are impossible. Prior research has primarily concentrated on categorizing existing models, with little attention paid to their intrinsic connections. The purpose of this study is to establish a unified framework that integrates GNNs based on spectral graph and approximation theory. The framework incorporates a strong integration between spatial- and spectral-based GNNs while tightly associating approaches that exist within each respective domain.
Indolizine derivatives related to ergoline. Derivatives of 7H-pyrrolo[3,2,1-i,j]quinoline, 7H-naphtho[1,2,3-h,i]indolizine, and 7H-pyrrolo[3,2,1-g,h]-4,7-phenanthroline (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIndolizine derivatives related to ergoline. Derivatives of 7H-pyrrolo[3,2,1-i,j]quinoline, 7H-naphtho[1,2,3-h,i]indolizine, and 7H-pyrrolo[3,2,1-g,h]-4,7-phenanthrolineMario Cardellini, Gian Mario Cingolani, Francesco Claudi, Gloria Cristalli, Ugo Gulini, and Sante MartelliCite this: J. Org. Chem. 1982, 47, 4, 688–692Publication Date (Print):February 1, 1982Publication History Published online1 May 2002Published inissue 1 February 1982https://pubs.acs.org/doi/10.1021/jo00343a017https://doi.org/10.1021/jo00343a017research-articleACS PublicationsRequest reuse permissionsArticle Views144Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Katalytische Hydrierung von Kohlenstoffdioxid zu Methanol unter Verwendung molekularer Katalysatoren (2016)

This thesis deals with the development and detailed investigation of the very first organometallic catalyst for the selective hydrogenation of CO2 to methanol. Organometallic catalysts were believed to allow the conversion of CO2 to methanol only via 1) the intermediate formation of CO via reverse watergas shift reaction (RWGS), leading to an unselective raction, or via 2) the intermediate formation of alkyl formates as stable intermediates, requiring a mixture of catalysts.The neutral complex [Ru(TMM)(Triphos)] (2) (TMM = trimethylenmethane, Triphos = 1,1,1-tris(diphenylphosphinomethyl)ethane) was shown to be active in the selective hydrogenation of CO2 to methanol without the need for stable intermediates, when applied in combination with an acidic additive (e.g. HNTf2 = bis(trifluoromethane)sulfonimide). The activity per metal centre of this system was comparable with the activity per metal centre of classical heterogeneous methanol catalysts. Based on mechanistic investigations, the cationic complex [Ru(OAc)(Triphos)(S)]NTf2 (14) (S = solvent or free coordination site) was developed as molecular catalyst for a system free of any additives. Under reaction conditions, complex 2/HNTf2 as well as complex 14 formed the cationic formate complex [Ru(O2CH)(Triphos)(THF)]NTf2 (8a) which was characterised spectroscopically and shown to be an intermediate. DFT calculations supported the assumption of a stepwise reduction of CO2 within the coordination sphere of a ruthenium-Triphos centre: A series of hydride transfer and protonolysis steps lead to the reduction of CO2 to formic acid, formaldehyde, and finally methanol. The facial coordination of the Triphos ligand as well as the high thermal stability of Ru-Triphos complexes are crucial factors for the unprecedented activity of the investigated complexes. Recycling of the catalytic system 2/HNTf2 was demonstrated using a biphasic system based on 2 methyltetrahydrofurane and water. Finally, immobilisation of 2/HNTf2 in an ionic liquid allowed its application in a continuous-flow process for the hydrogenation of CO2 to methanol.
Optimum block division in CBFM for fast MoM (2012)

Method of Moments (MoM) is one of the powerful method for numerical analysis of antennas or scatterers [1]. Recently, many fast MoM for large scale problems has been proposed and various large scattering problems have been analyzed [2], [3]. In general, there is trade-off between the accuracy of solution and CPU time in the fast MoM. Nevertheless, in practice, the pattern of the large scattering problems can be obtained accurately using the fast MoM because the scattering pattern is obtained by integration of current over an analysis model. On the other hand, it is difficult to obtain current or input impedance of an antenna in large radiation problems accurately by using the fast MoM because the current is evaluated by the weighted residual and it is not necessarily accurate at each point. Because the accuracy of the solution and CPU time of the fast MoM depend on some parameters, parameter optimization is indispensable to keep a balance between those of the fast MoM.
The Quinone Methide Aurin Is a Heat Shock Response Inducer That Causes Proteotoxic Stress and Noxa-dependent Apoptosis in Malignant Melanoma Cells (2014)

Pharmacological induction of proteotoxic stress is rapidly emerging as a promising strategy for cancer cell-directed chemotherapeutic intervention. Here, we describe the identification of a novel drug-like heat shock response inducer for the therapeutic induction of proteotoxic stress targeting malignant human melanoma cells. Screening a focused library of compounds containing redox-directed electrophilic pharmacophores employing the Stress & Toxicity PathwayFinder(TM) PCR Array technology as a discovery tool, a drug-like triphenylmethane-derivative (aurin; 4-[bis(p-hydroxyphenyl)methylene]-2,5-cyclohexadien-1-one) was identified as an experimental cell stress modulator that causes (i) heat shock factor transcriptional activation, (ii) up-regulation of heat shock response gene expression (HSPA6, HSPA1A, DNAJB4, HMOX1), (iii) early unfolded protein response signaling (phospho-PERK, phospho-eIF2α, CHOP (CCAAT/enhancer-binding protein homologous protein)), (iv) proteasome impairment with increased protein-ubiquitination, and (v) oxidative stress with glutathione depletion. Fluorescence polarization-based experiments revealed that aurin displays activity as a geldanamycin-competitive Hsp90α-antagonist, a finding further substantiated by molecular docking and ATPase inhibition analysis. Aurin exposure caused caspase-dependent cell death in a panel of human malignant melanoma cells (A375, G361, LOX-IMVI) but not in non-malignant human skin cells (Hs27 fibroblasts, HaCaT keratinocytes, primary melanocytes) undergoing the aurin-induced heat shock response without impairment of viability. Aurin-induced melanoma cell apoptosis depends on Noxa up-regulation as confirmed by siRNA rescue experiments demonstrating that siPMAIP1-based target down-regulation suppresses aurin-induced cell death. Taken together, our data suggest feasibility of apoptotic elimination of malignant melanoma cells using the quinone methide-derived heat shock response inducer aurin.