gebhart/patrepeval huggingface dataset:
Rapid modification of the glycocalyx caused by ischemia-reperfusion is inhibited by adenosine A2Areceptor activation (2003)

Ischemia-reperfusion (I/R) has been shown to cause microvascular dysfunction and to alter the appearance of the glycocalyx in electron micrographs. We hypothesized that I/R injury might alter the structure and/or permeability of the glycocalyx. Prior work had shown a role for adenosine in protection from I/R injury, and, therefore, we also explored the idea that activation of the adenosine A(2A) receptor would attenuate I/R glycocalyx injury. Here, we report that I/R causes a rapid and dramatic decrease in the ability of the glycocalyx to exclude FITC-Dextran 70 (Dex70). Over a reperfusion period of 45 min, the glycocalyx dye exclusion zone for Dex70 decreased by one-half in capillaries and postcapillary venules, whereas the red blood cell exclusion zone was very slightly reduced in capillaries only. Pretreatment with the A(2A) agonist ATL-146e significantly inhibited the changes in both vessel types. The modifications of the glycocalyx appear to be an early step in the inflammatory cascade typically associated with reperfusion injury, and adenosine A(2A) receptor activation may play a role in protection from this injury.
43‐3: Distinquished Paper: Brilliant Cosmetic Film for Ambient Displays, with Cholesteric Liquid Crystal (2018)

A brilliant cosmetic film with polymerized cholesteric material (PCM) has been developed. The film features a variety of colors by helical pitch gradients, diffusive texture, and arbitrary color patterns. It hides the display when turned off, and transmits display images when turned on. We believe it could change the display in the Off‐state from the conventional black wall to specially designed decorations. In addition, they can be applied to hidden sensors.
Spectrum slicer for snapshot spectral imaging (2015)

We propose and demonstrate an optical component that overcomes critical limitations in our previously demonstrated high-speed multispectral videography—a method in which an array of periscopes placed in a prism-based spectral shaper is used to achieve snapshot multispectral imaging with the frame rate only limited by that of an image-recording sensor. The demonstrated optical component consists of a slicing mirror incorporated into a 4f-relaying lens system that we refer to as a spectrum slicer (SS). With its simple design, we can easily increase the number of spectral channels without adding fabrication complexity while preserving the capability of high-speed multispectral videography. We present a theoretical framework for the SS and its experimental utility to spectral imaging by showing real-time monitoring of a dynamic colorful event through five different visible windows.
A New Cleaning Technique for X-Ray Masks in Alkaline Solutions by Direct Control of Electrochemical Potential (2000)

This paper describes an electrochemical surface cleaning (ECSC) technique newly developed for removal of particulate contamination on X-ray masks employing WN x absorbers. In this technique, the electrochemical potential of absorber films is precisely controlled for preventing corrosion or etching of the films during their immersion in alkaline solutions. The particle removal efficiency and the stress change of WN x absorbers were examined and compared with those after the conventional cleaning operated under electrically floating condition. The etched depth (and thus etch rate) of WN x films in alkaline solutions was measured using an in-situ quartz-crystal-microbalance technique. Furthermore, X-ray photoelectron spectroscopy and atomic force microscopy were employed to characterize WN x film surfaces. Mechanisms responsible for a large stress change observed in the case of conventional cleaning are discussed. Moreover, it is demonstrated that the ECSC operated at cathodic potentials yields high removal efficiencies for a variety of particulates without change in film thickness and stress between before and after cleaning.
Organic Complementary Circuits: Remarkable Enhancement of Hole Transport in Top‐Gated N‐Type Polymer Field‐Effect Transistors by a High‐k Dielectric for Ambipolar Electronic Circuits (Adv. Mater. 40/2012) (2012)

On page 5433, Yong-Young Noh, Antonio Facchetti, Kang-Jun Baeg, and co-workers report that high performance ambipolar complementary inverters and ring oscillators are provided by a remarkable enhancement of both hole injection and transport for n-channel dominant N2200 OFETs. The significant enhancement of hole mobility in N2200 OTFTs is attributed to the strong dipoles in fluorinated high-k gate dielectric blend of P(VDF-TrFE):PMMA.
Abstract B190: Pharmacokinetics of the AKT inhibitor CCT128930 from dried blood spots sampled from caudal bleeding compared with conventional cardiac puncture. (2011)

Abstract There has been much increase in the use of blood spots in recent years as a result of the ease of storage and transport of blood dried on cards compared with frozen plasma. In preclinical studies in oncology, mice are the model used for therapy experiments and blood spots allow full pharmacokinetic (PK) studies in 3–4 animals versus 21–27 for conventional plasma pharmacokinetics analysis, saving animals and decreasing compound usage. We here apply the blood spots technology to the early pharmacokinetic analysis of the AKT inhibitor CCT128930 dosed i.v. at 10mg/kg and bled from the tail vein. The PK are very reproducible between individual mice and the blood levels are not affected by the type of anticoagulant used (heparin or EDTA) or by use of the FTA-DMPK card. CCT128930 shows a blood clearance of 0.092L/h (&amp;lt;liver blood flow) and volume of distribution of 140mL. However, the PK parameters evaluated in blood water by conventional methods (cardiac puncture) differ significantly to those from the blood spot experiments. The overall blood clearance is 1.6-fold higher following blood measurement in samples taken by cardiac puncture versus serial tail bleed. The 6h post-dosing concentrations of CCT128930 following caudal sampling are 10-fold higher than that measured after cardiac puncture although there is no difference in Cmax. These data suggest that the serial bleeding from the tail vein affects the PK parameters of this compound compared with conventional bleeding. We have used blood spots extensively in our drug discovery programs checking the 6h sample versus conventional cardiac bleed and this strategy has allowed us to save over 50% of animals in the last year in our preclinical PK evaluations. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2011 Nov 12-16; San Francisco, CA. Philadelphia (PA): AACR; Mol Cancer Ther 2011;10(11 Suppl):Abstract nr B190.
Abnormal left ventricular torsion and cardiac autonomic dysfunction in subjects with type 1 diabetes mellitus (2011)

Left ventricular torsion is increased and cardiac energetics are reduced in uncomplicated type 1 diabetes mellitus (T1DM). Our aim was to determine the relationships of these abnormalities to cardiovascular autonomic neuropathy (CAN) in subjects with T1DM. A cross-sectional study was conducted in 20 subjects with T1DM free of known coronary heart disease attending an outpatient clinic. Cardiovascular autonomic neuropathy was assessed using heart rate variability studies and the continuous wavelet transform method. Left ventricular function was determined by speckle tracking echocardiography. Magnetic resonance spectroscopy and stress magnetic resonance imaging were used to measure cardiac energetics and myocardial perfusion reserve index, respectively. Twenty subjects (age, 35 ± 8 years; diabetes duration, 16 ± 9 years; hemoglobin A(1c), 8.0% ± 1.1%) were recruited. Forty percent of the subjects exhibited definite or borderline CAN. Log peak radial strain was significantly increased in subjects with CAN compared with those without (1.56 ± 0.06 vs 1.43 ± 0.14, respectively; P = .011). Data were adjusted for log duration of diabetes, and log left ventricular torsion correlated (r = 0.593, P = .01) with log low-frequency to high-frequency ratio during the Valsalva maneuver. Log isovolumic relaxation time correlated significantly with log Valsalva ratio and log proportion of differences in consecutive RR intervals of normal beats greater than 50 milliseconds during deep breathing. However, CAN did not correlate with cardiac energetics or myocardial perfusion reserve index. Spectral analysis of low-frequency to high-frequency ratio power during the Valsalva maneuver is associated with altered left ventricular torsion in subjects with T1DM. Parasympathetic dysfunction is closely associated with diastolic deficits. Cardiovascular autonomic neuropathy is not however the principal cause of impaired cardiac energetics. The role of CAN in the development of cardiomyopathy warrants further evaluation.
The “Nodular” α Form of Isotactic Polypropylene: Stiff and Strong Polypropylene with High Deformability (2017)

A study of the nucleating effects of isotactic poly(trimethylallylsilane) (iPTMAS) and poly(vinylcyclohexane) (iPVCH) for isotactic polypropylene (iPP) and their influence on the mechanical behavior of iPP is reported. The particles of catalyst are covered by poly(trimethylallylsilane) or poly(vinylcyclohexane) by polymerization of the corresponding monomers before polymerization of propylene. The method guarantees that the nucleating agents are perfectly dispersed into the iPP samples, with their consequent high efficiency. Isotactic poly(vinylcyclohexane) and poly(trimethylallylsilane) favor crystallization from the melt of α and β forms, respectively. Both nucleating agents affect the morphology greatly reducing the size of shperulites. This in turn affects the mechanical properties improving ductility and flexibility. All nucleated samples crystallize by rapid cooling from the melt in the α form and not in the mesophase, as occurs in the pure iPP. The resulting α form presents nodular crystals and behaves as a stiff material with high deformability.
GaN-based vertical-cavity surface-emitting lasers with tunnel junction contacts grown by metal-organic chemical vapor deposition (2018)

We report the first demonstration of III–nitride vertical-cavity surface-emitting lasers (VCSELs) with tunnel junction (TJ) intracavity contacts grown completely by metal–organic chemical vapor deposition (MOCVD). For the TJs, n++-GaN was grown on in-situ activated p++-GaN after buffered HF surface treatment. The electrical properties and epitaxial morphologies of the TJs were first investigated on TJ LED test samples. A VCSEL with a TJ intracavity contact showed a lasing wavelength of 408 nm, a threshold current of ∼15 mA (10 kA/cm2), a threshold voltage of 7.8 V, a maximum output power of 319 µW, and a differential efficiency of 0.28%.
Sharing cloud services: user authentication for social enhancement of home networking (2011)

A user centric approach to authentication for home networks is proposed. A zero-knowledge-proof (ZKP) authentication is used to leverage the emerging cloud infrastructure allowing users to temporarily transfer their service and content rights within a trusted environment such as a friend's home. This approach enables the sharing of personalized content and more sophisticated network-based services over a conventional TCP/IP infrastructure. Experimental results derived from a reference prototype are presented. These demonstrate the practicality of the underlying approach. The potential to develop new cloud services for "social" home networks is also discussed.
Hematopoiesis: Proceedings of a UCLA symposium held at Tamarron, Colorado, February 20-26, 1989 (1990)

Hematopoietic Growth Factors: Structure and Function Cytokine Gene Expression Hematopoietic Growth Factor Receptors Stromal Cells and the Hematopoietic Microenvironment Leukemic Cells and Cell Lines Hematopoietic Growth Factors: In Vivo Models and Clinical Studies.
Transparent dynamic metasurface for a visually unaffected reconfigurable intelligent surface: controlling transmission/reflection and making a window into an RF lens (2021)

Reconfigurable intelligent surfaces (RISs) that dynamically manipulate scattered waves have attracted much attention regarding accommodating coverage holes in wireless communication systems using radio wave frequencies higher than millimeter waves. RISs generally actualized through metasurface technologies must be visually unaffected so that they can be installed in various locations such as existing walls and glass windows in environments where propagation should be controlled. We propose a novel method that dynamically controls scattering characteristics of metasurfaces while achieving a large area and high optical transparency. For transparency in the visible light range, we use transparent glass as a substrate and meshed metal patterns. Furthermore, by stacking a metasurface substrate onto another transparent substrate and controlling the interlayer distance, we achieve dynamic control of the scattered waves over a large area in the 28-GHz band. Fabricated prototypes successfully operate when switching transmission and reflection modes, exhibiting extremely low loss of less than -1 dB. In metasurface lenses that can be attached to glass windows in outdoor-to-indoor scenarios, the lens gain of 25.4 dB is achieved for a static lens, and dynamic switching operation between single focus and dual focus is also successfully verified for a dynamic lens.
Evaluation of DNA colony hybridization and other techniques for detection of virulence in Yersinia species (1989)

The virulence of yersiniae varies according to (i) species and biotype and (ii) possession of a 67- to 72-kilobase virulence plasmid. Y. pestis, Y. pseudotuberculosis, and biotypes 1B, 2, 3, 4, and 5 of Y. enterocolitica are inherently virulent but express full virulence only when in possession of a virulence plasmid. Other Yersinia species and biotypes 1A and 3B of Y. enterocolitica are seldom implicated in disease. In this study, we prepared DNA probes from eight nonoverlapping regions of the virulence plasmid of a strain of Y. enterocolitica and from the inv and ail chromosomal loci responsible for the invasive capacity of Y. enterocolitica and Y. pseudotuberculosis. The probes were used in colony hybridization experiments to investigate 156 yersiniae of various species and biotypes and of differing virulence. Probes prepared from the inv gene of Y. pseudotuberculosis hybridized with Y. pseudotuberculosis and Y. pestis only, whereas an analogous probe prepared from Y. enterocolitica hybridized with all species and biotypes of yersiniae (but not with other bacteria) regardless of virulence or potential virulence. Probes prepared from the ail region of Y. enterocolitica reacted almost exclusively with Y. enterocolitica strains of pathogenic biotypes. Probes prepared from the virulence plasmid of a serogroup O:8, biotype 1B isolate of Y. enterocolitica identified virulent yersiniae in all species with a high degree of sensitivity and specificity. These probes did not react with yersiniae of avirulent biotypes or species. Of the other assays of virulence evaluated (calcium dependence, binding of crystal violet, and pyrazinamidase activity), binding of crystal violet provided a simple means for identifying plasmid-bearing strains.
Simultaneous quasi-RHCP and LHCP radiation in the near field of planar RFID antennas (2016)

The concept of quasi-circular polarization (CP) of the EM field produced in the near field by a planar RFID antenna is discussed. Optimized CP near field performance is obtained by shaping the layout of periodic EM coupled strips forming the antenna aperture. It is shown that the specifically designed planar antenna can simultaneously produce the right-hand circular polarization (RHCP) and left-hand circular polarization (LHCP) in the spatially different areas of the near field zone. The results of EM simulation illustrate the mechanism of producing the quasi-CP radiation in the antenna near field zone at different distances from the antenna surface.
Energy-delay estimation technique for high-performance microprocessor VLSI adders (2004)

We motivate the concept of comparing VLSI adders based on their energy-delay trade-offs and present a technique for estimating the energy-delay space of various high-performance VLSI adder topologies. Further, we show that our estimates accurately represent tradeoffs in the energy-delay space for high-performance 32-bit and 64-bit processor adders in 0.13/spl mu/m and 0.10/spl mu/m CMOS technologies, with an accuracy of 8% in delay estimates and 20% in energy estimates, compared with simulated data.
Excited-state Raman spectroscopic study of bonding changes in potassium pentacyanonitrosylmanganate(3-) induced by nitrosyl bending (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTExcited-state Raman spectroscopic study of bonding changes in potassium pentacyanonitrosylmanganate(3-) induced by nitrosyl bendingJing Huei Perng and Jeffrey I. ZinkCite this: Inorg. Chem. 1988, 27, 8, 1403–1406Publication Date (Print):April 1, 1988Publication History Published online1 May 2002Published inissue 1 April 1988https://pubs.acs.org/doi/10.1021/ic00281a021https://doi.org/10.1021/ic00281a021research-articleACS PublicationsRequest reuse permissionsArticle Views56Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Cloning of murine tissue factor and regulation of gene expression by transforming growth factor type beta 1. (1991)

We have cloned a serum- and cycloheximide-inducible mRNA from AKR-2B murine fibroblasts which encodes a protein with significant sequence similarity to human tissue factor, a cellular initiator of the blood coagulation cascade. Information derived from this clone was used to establish the presence of a virtually identical sequence in mouse brain. Most importantly, cDNA-directed expression in a quail fibroblast cell line produced high levels of tissue factor procoagulant activity, confirming the identity of this protein as murine tissue factor. Additional studies demonstrate that transforming growth factor type beta 1 stimulates tissue factor gene transcription and is a potent inducer of tissue factor procoagulant activity in fibroblasts. Other tested mitogens such as platelet-derived growth factor, epidermal growth factor, and insulin were weak inducers. These results may reflect a role for transforming growth factor beta 1 in the maintenance of hemostasis or, alternatively, a role for tissue factor in cellular functions unrelated to blood coagulation.
Real-time analysis and management of big time-series data (2013)

The ability to process and analyze large volumes of time-series data is in increasing demand in various domains including health care, finance, energy and utilities, transportation, and cybersecurity. Despite the broad use of time-series data worldwide, the design of a system to easily manage, analyze, and visualize large multidimensional time series, with dimensions on the order of hundreds of thousands, is still a challenging endeavor. This paper describes the Streaming Time-Series Analysis and Management (STAM) system as a solution to this problem. STAM provides the capability to glean actionable information from continuously changing time series with thousands of dimensions, in real time. STAM exploits the IBM InfoSphere® Streams platform and allows for general-purpose large-scale time-series analytics for applications including anomaly detection, modeling, smoothing, forecasting, and tracking. In addition, the system provides user-friendly tools for managing, deploying, and initiating analytics on large-scale data streams of interest, and provides a web-based graphical visualization interface that allows highlighting of events of interest with interactive menus. In this paper, we describe the system and illustrate its use in a large-scale system-monitoring application.
Antitumor effect of stilbenoids from Vateria indica against allografted sarcoma S‐180 in animal model (2003)

Dipterocarpaceous plants contain various resveratrol oligomers that exhibit a variety of biological activities, such as antibacterial and antitumor effects. Previously, we found that vaticanol C, a resveratrol tetramer, exhibits strong cytotoxicity against various tumor cell lines. In the present study, we examined the antitumor activity of the ethanol extract from the stem bark of Vateria indica, which has been traditionally used for health and healing diseases as Ayurveda in India. High-performance liquid chromatography analysis showed that the extract contains bergenin, hopeaphenol, vaticanol B, vaticanol C, and epsilon-viniferin. The in vitro assay displayed the extract's anti-cancer activity against mouse sarcoma 180 cells (IC50=29.5 microM). In the animal study, the tumor growth of sarcoma S-180 cells subcutaneously allografted in DDY mice was significantly retarded by oral administration of the extract (30 or 100 mg/kg body weight: P < 0.001). The extract did not show significant toxicity to mice even at a dosage of 1000 mg/kg body weight by daily oral administration for 28 days. These results demonstrated that the ethanol extract containing various stilbenoids from the stem bark of V. indica has the potent antitumor activity.