gebhart/patrepeval huggingface dataset:
Asymptotic Analysis of Bifurcations in Feedforward Networks (2021)

A feedforward network is a unidirectionally coupled chain of dynamical systems in which the first cell is coupled to itself, and each successive cell is coupled to the next one. Feedforward networks have gained considerable interest because of their potential to enhance signal amplification and to manipulate the frequency of oscillations. Indeed, it has been shown that the growth rate of the bifurcation undergone by the final cell is much larger than the expected square root growth rate associated with the standard Hopf bifurcation. In this paper, we present a new approach to studying this growth rate phenomenon. We employ a two-time-scale analysis and asymptotic approximations to detect behavior associated with the growth rate phenomenon that has not been previously observed. In particular, we show that the Hopf bifurcation is not the only bifurcation capable of exhibiting this large growth rate behavior. Using asymptotic methods we show that it is not a special property of the Hopf bifurcation that allows for this accelerated growth rate; it is a combination of the unidirectional coupling and the higher-degree nonlinearities that cause this effect. Furthermore, we show that this large growth rate need not persist away from the bifurcation. In fact, the growth rate is asymptotic to the standard square root growth rate as the bifurcation parameter increases.
Proteomic identification and early validation of complement 1 inhibitor and pigment epithelium‐derived factor: Two novel biomarkers of Alzheimer's disease in human plasma (2008)

Emerging disease modifying therapeutic strategies for Alzheimer's disease (AD) have generated a critical need for biomarkers of early stage disease. Here, we describe the identification and assessment of a number of candidate biomarkers in patients with mild to moderate probable AD. Plasma from 47 probable Alzheimer's patients and 47 matched controls were analysed by proteomics to define a significant number of proteins whose expression appeared to be associated with AD. These were compared to a similar proteomic comparison of a mouse transgenic model of amyloidosis, which showed encouraging overlap with the human data. From these studies a prioritised list of 31 proteins were then analysed by immunoassay and/or functional assay in the same human cohort to verify the changes observed. Eight proteins continued to show significance by either immunoassay or functional assay in the human plasma and these were tested in a further set of 100 probable AD patients and 100 controls from the original cohort. From our data it appeared that two proteins, serpin F1 (pigment epithelium-derived factor) and complement C1 inhibitor are down-regulated in plasma from AD patients.
Structure of bovine β-lactoglobulin–lactoferrin coacervates (2014)

Lactoferrin (LF) and β-lactoglobulin (BLG) are among the protein pairs that exhibit heteroprotein coacervation, a unique and relatively unexamined type of liquid-liquid phase separation (LLPS). In prior work we found that LF and BLG undergo coacervation at highly constrained conditions of pH, ionic strength and protein stoichiometry. The molar stoichiometry in coacervate and supernatant is LF : BLG2 1 : 2 (where BLG2 represents the 38 kDa BLG dimer), suggesting that this is the primary unit of the coacervate. The precise balance of repulsive and attractive forces among these units, thought to stabilize the coacervate, is achieved only at limited conditions of pH and I. Our purpose here is to define the process by which such structural units form, and to elucidate the forces among them that lead to the long-range order found in equilibrium coacervates. We use confocal laser scanning microscopy (CLSM), small angle neutron scattering (SANS), and rheology to (1) define the uniformity of interprotein spacing within the coacervate phase, (2) verify structural unit dimensions and spacing, and (3) rationalize bulk fluid properties in terms of inter-unit forces. Electrostatic modeling is used in concert with SANS to develop a molecular model for the primary unit of the coacervate that accounts for bulk viscoelastic properties. Modeling suggests that the charge anisotropies of the two proteins stabilize the dipole-like LF(BLG2)2 primary unit, while assembly of these dipoles into higher order equilibrium structures governs the macroscopic properties of the coacervate.
Challenge of Near-Field Recording beyond 50.4 Gbit/in2 (2002)

The possibility of an areal density over 50 Gbit/in2 was examined in near-field phase-change recording. The disk structure was optimized to maximize readout signals under the land-and-groove recording condition at a tracking pitch of 160 nm. We also evaluated the signal crosstalk from adjacent tracks. Eye diagrams of 50.4 Gbit/in2 areal density were demonstrated using 1.5 NA optics and a GaN laser diode. The track pitch and linear bit density are 160 nm and 80 nm/bit, respectively. The transmission electron microscope (TEM) micrograph of recorded amorphous marks at an areal density of 50.4 Gbit/in2 is also presented.
Anisotropic exceptional points of arbitrary order and exceptional ellipses (2020)

Two anisotropic exceptional points (EPs) of arbitrarily high order are found in a class of random non-Hermitian systems, where the non-Hermiticity emerges from non-reciprocal hoppings. Both eigenvalues and phase rigidity show different asymptotic forms near the anisotropic EP in two orthogonal directions in the parameter space, making them anisotropic EPs. The critical exponents of phase rigidity follow universal rules near an anisotropic EP, and the exponents depend on the dimension of the Hamiltonian as well as the approaching direction, but are independent of the random configurations. We found multiple ellipses formed by EPs of order two converge to the two high-order EPs in the parameter space. A ring of high-order EPs is formed when all ellipses coalesce for some particular configurations.
Thermally induced flux motion in grain aligned Y-Ba-Cu-O (1991)

The flux-flow-induced Nernst effect was studied in grain aligned polycrystalline Y-Ba-Cu-O. Nernst voltages have been measured for magnetic fields up to 6 T and temperatures ranging from 75 K to 100 K. The observed behavior is similar to that seen in low-temperature superconductors. The linear temperature dependence of the Nernst voltage on the applied temperature gradient has been verified. The flux-flow resistivity has been measured in magnetic fields up to 6 T. The broadening of the transition curve with increasing applied fields is evident. The resistivity is approximately five times higher than that measured in a high-quality single crystal. The increase may be attributable to intergranular effects. The measured Nernst voltages and flux-flow resistivities have been used to calculate the flux-line transport entropy. A comparison with the transport entropy derived from single-crystal data indicates that the polycrystalline transport entropy is a factor of 5 smaller. The discrepancy may be related to the intergranular resistivities which are not flux-flow-induced, leading to an artificial suppression of the flux-flow viscosity and the calculated transport entropy.
6G-1 Characterization of In Vivo Atherosclerotic Plaques in the Carotid Artery with Acoustic Radiation Force Impulse Imaging (2006)

Acoustic Radiation Force Impulse (ARFI) imaging is a useful method for characterizing the local mechanical properties of tissue. ARFI imaging uses high energy, focused ultrasound pulses to generate small displacements (1-10 mum) in tissue. The response of tissue to these localized forces is observed using a series of imaging pulses, which track displacement of the tissue. ARFI imaging is complementary to B-mode imaging, and can readily distinguish between stiff and soft regions of tissue with high contrast. Currently, physicians cannot easily determine whether atherosclerotic plaques in carotid arteries are vulnerable to rupture. We are investigating the use of ARFI imaging to characterize atherosclerotic plaque in carotid arteries and to guide the treatment of these plaques. We have created custom beam sequences on a Siemens Antarestrade scanner to implement ARFI imaging. Five patients with atherosclerotic plaque and four volunteers without known atherosclerotic plaque underwent B-Mode and ARFI scanning of their carotid arteries. Measurements of the complete vessel wall (adventitial layer plus IMT) with ARFI imaging are shown to be consistent with measurements of the intima-media thickness (IMT) in normal B-mode scans. In plaque-filled vessels, the mean near-wall IMT was 0.92 mm and the mean far-wall IMT was 1.24 mm. In ARFI imaging, vessel walls have mean thicknesses of 2.17 mm and 2.17 mm for the near and far walls, respectively. For volunteers without plaques, the near and far wall IMT measurements were 0.52 and 0.54 mm, respectively and the ARFI vessel thicknesses were 1.39 and 1.26 mm. Both IMT measurements and ARFI measurements were significantly (p < 0.005) greater for patients with plaques. We demonstrate high-resolution ARFI images of carotid plaques depicting their complex mechanical structure, which often involve regions of soft and hard plaque. We discuss methods of improving the contrast and resolution of ARFI vascular images
Luminescent Ionogels Based on Europium-Doped Ionic Liquids Confined within Silica-Derived Networks (2006)

Luminescent ionogels were prepared by doping an europium(III) tetrakis β-diketonate complex into an imidazolium ionic liquid, followed by immobilization of the ionic liquid by confinement in a silica network. The ionogels were obtained by a non-hydrolytic method as perfect monoliths featuring both the transparency of silica and the ionic conductivity performances of ionic liquids. The ionogels contain 80 vol % of ionic liquid. The organic−inorganic hybrid materials showed a very intense red photoluminescence under ultraviolet irradiation. The red emission has a very high coloric purity.
Thermal management in heat assisted magnetic recording (2005)

A laser on slider system assuming a custom sized laser constructed using commercially available processes is modeled. Since the air-bearing surface (ABS) acts as one of the main paths for heat removal from the head, correctly capturing the thermal transport of this interface is essential to accurate modeling of the head temperature rise. Therefore, a thermal characterization spin stand that allows characterization of this interface have been built and employed. A conventional hard drive slider was subjected to thermal load from an infrared laser. The laser is focused through a glass medium (when present) and onto the air-bearing surface of the slider. The optical power absorbed and its effect on magnetic recording temperature were determined by measuring the reflectivity of each target location on the ABS while the thermally induced change in the magnetoresistance of the read element was simultaneously collected. As the laser spot was translated to different locations on the ABS, a thermal "map" of the slider that has been normalized to unit absorbed optical power was constructed.
Mass spectrometric analysis of combinatorial peptide libraries derived from the tandem repeat unit of MUC2 mucin (2003)

Four 19-member synthetic peptide libraries, based on the TX1TX2T epitope motif of the mucin-2 gastrointestinal glycoprotein (MUC2) and ranging in peptide length from dipeptides to 15-mers (XT, TXT, TQTXT and KVTPTPTPTGTQTXT), were synthesized by combinatorial solid phase peptide synthesis using the portioning-mixing combinatorial approach, and analysed by electrospray ionization mass spectrometry at different (1000-10000) resolutions. Most of the components of the individual libraries could be easily identified in a single-stage molecular mass screening experiment. The resolving power of the instrument becomes an important factor above 800-1000 Da molecular mass, when predominantly multiply charged molecular ions are formed. Approaches to the identification of isobars (glutamine/lysine), isomers leucine/isoleucine) and sequence variations by tandem mass spectrometry, and/or by high-performance liquid chromatography-mass spectrometry are outlined.
Design and Testing of a Carbon-Fiber-Wrapped Synchronous Reluctance Traction Motor (2018)

Synchronous reluctance machines are very appealing for high-speed traction applications due to their robustness, simple structure, absence of magnets, and simple control. The absence of magnets means that synchronous reluctance machines are not susceptible to price variability and sustainability of rare-earth materials. Also, there are no concerns about demagnetization or uncontrolled generation mode. However, the challenge of achieving a good constant power to speed ratio is dependent on the mechanical aspects of the design. Conventional synchronous reluctance designs perform poorly compared to permanent magnet machines due to the presence of bridges and/or center posts that provide a path for performance-robbing leakage flux and the absence of permanent magnets that help saturate the bridges and/or center posts. Elimination or reduction of these features presents a challenge for rotor mechanical retention due to the reduction in radial stiffness that these members provide mainly for high-speed applications. A carbon-fiber sleeve on the rotor will provide the needed mechanical strength to enable a reduction of bridges and/or center posts. This paper will present the design details, analysis, manufacturing, and test results of a proof-of-concept carbon-fiber-wrapped synchronous reluctance machine targeting traction applications.
Preparation and reactions of tantalum alkylidene complexes containing bulky phenoxide or thiolate ligands. Controlling ring-opening metathesis polymerization activity and mechanism through choice of anionic ligand (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and reactions of tantalum alkylidene complexes containing bulky phenoxide or thiolate ligands. Controlling ring-opening metathesis polymerization activity and mechanism through choice of anionic ligandKevin C. Wallace, Andy H. Liu, John C. Dewan, and Richard R. SchrockCite this: J. Am. Chem. Soc. 1988, 110, 15, 4964–4977Publication Date (Print):July 1, 1988Publication History Published online1 May 2002Published inissue 1 July 1988https://pubs.acs.org/doi/10.1021/ja00223a014https://doi.org/10.1021/ja00223a014research-articleACS PublicationsRequest reuse permissionsArticle Views852Altmetric-Citations158LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Microwave-Assisted Synthesis of High-Voltage Nanostructured LiMn1.5Ni0.5O4 Spinel: Tuning the Mn3+ Content and Electrochemical Performance (2013)

The LiMn1.5Ni0.5O4 spinel is an important lithium ion battery cathode material that has continued to receive major research attention because of its high operating voltage (∼4.8 V). This study interrogates the impact of microwave irradiation on the Mn(3+) concentration and electrochemistry of the LiMn1.5Ni0.5O4 spinel. It is shown that microwave is capable of tuning the Mn(3+) content of the spinel for enhanced electrochemical performance (high capacity, high capacity retention, excellent rate capability, and fast Li(+) insertion/extraction kinetics). This finding promises to revolutionize the application of microwave irradiation for improved performance of the LiMn1.5Ni0.5O4 spinel, especially in high rate applications.
Radius‐Maumenee syndrome: A case series with a long‐term follow‐up (2023)

The aim of the case series is to highlight the surgical challenges experienced like failed intervention, choroidal effusion, a postoperative cystoid macular oedema, and describe treatment options for Radius-Maumenee syndrome. Authors reported on 3 bilateral cases of Radius-Maumenee syndrome which underwent medical treatment, trabeculectomy with Mitomycin C, implantation with XEN45, Ahmed glaucoma valve, Baerveldt glaucoma implant, and cyclophotocoagulation.
IC‐P‐220: CLINICAL UPDATE: 18F‐PI‐2620, A NEXT GENERATION TAU PET AGENT EVALUATED IN SUBJECTS WITH ALZHEIMER'S DISEASE AND PROGRESSIVE SUPRANUCLEAR PALSY (2018)

Intracellular tau deposition is a key pathologic feature of Alzheimer's disease (AD) and other neurodegenerative disorders. Several PET-probes have been developed for in vivo detection of brain tau load. Some tau radiotracers have limitations in regard to off-target binding and tau detection in non-AD tauopathies like PSP. 18F-PI-2620 is a novel tau PET-tracer with a high binding-affinity for aggregated tau. Preclinically, 18F-PI-2620 binds to both tau isoforms and is able to depict tau-deposits in AD brain sections from different Braak stages, as well as deposits in PSP. Data from a first-in-human study shows the potential of 18F-PI-2620 to visualize tau deposition in subjects with AD and PSP, in comparison to non-demented controls (NDCs). An update of the clinical data will be presented. In an ongoing clinical imaging study, participants diagnosed with mild AD, non-AD tauopathies, or NDCs undergo dynamic PET imaging for 180 min. Test/Retest study in NDC and AD has been performed including repeat-scanning and full arterial blood sampling. Imaging data show robust brain uptake and fast wash-out in non-target regions with peak SUVs > 4. There was no increased off-target uptake seen in brain regions like basal ganglia as noted for first generation tau agents as well as no relationship with age. In AD, focal asymmetric uptake was evident in temporal and parietal lobes, precuneus, and posterior cingulate. SUVr time curves demonstrate a plateau at 60-90 min p.i. with resultant SUVrs of up to 4 in abnormal regions, whilst NDCs demonstrated lower SUVrs (1.0-1.2) in comparable brain regions. Importantly, PSP subjects demonstrated focal increased uptake in the globus pallidus and substantia nigra. Initial pharmacokinetic modeling indicates that SUVr from 60-90 min could be a good proxy for DVR, pending full validation. 18F-PI-2620 PET data in AD, PSP and NDC demonstrate favorable kinetics and high target specificity with low off-target activity and high signal in regions of expected tau pathology . PI-2620 SUVr images of a non-demented control (NDC) and AD subject (60-90 min p.i. using cerebellar cortex as reference region).
Shared and organism-specific host responses to childhood diarrheal diseases revealed by whole blood transcript profiling (2018)

Globally, diarrheal diseases are a leading cause of death in children under five and disproportionately affect children in developing countries. Children who contract diarrheal diseases are rarely screened to identify the etiologic agent due to time and cost considerations associated with pathogen-specific screening and hence pathogen-directed therapy is uncommon. The development of biomarkers to rapidly identify underlying pathogens could improve treatment options and clinical outcomes in childhood diarrheal diseases. Here, we perform RNA sequencing on blood samples collected from children evaluated in an emergency room setting with diarrheal disease where the pathogen(s) present are known. We determine host response gene signatures specific to Salmonella, Shigella and rotavirus, but not E. coli, infections that distinguish them from each other and from healthy controls. Specifically, we observed differential expression of genes related to chemokine receptors or inflammasome signaling in Shigella cases, such as CCR3, CXCR8, and NLRC4, and interferon response genes, such as IFI44 and OASL, in rotavirus cases. Our findings add insight into the host peripheral immune response to these pathogens, and suggest strategies and limitations for the use host response transcript signatures for diagnosing the etiologic agent of childhood diarrheal diseases.
Experimental Investigation of an IR-UWB Positioning System with Comparators (2007)

Impulse Radio (IR)-Ultra Wideband (UWB) enables accurate ranging due to very short duration pulses. Therefore, UWB may provide accurate positioning capability. In order to relax the complexity in circuit implementation, UWB system with low resolution analog digital converters (ADCs) has been investigated. In this paper, the accuracy of UWB positioning with comparators is investigated through experiment. The accuracy of positioning with comparators is compared to that with 8 [bit] ADCs, and effectiveness of the system with the comparators is confirmed within the area of 1.8 × 1.8 [m].
Improving risk assessment methodology (2009)

In order to manage risks to the IT environments and to satisfy government and industry regulations, most enterprises are required to conduct risk assessments. These risk assessments are used to drive organizational decisions on information security. However, despite this need, current approaches lack granular guidance on some key steps and have focused on qualitative data rather than quantitative data which reduces the value of the results for the decision makers. This paper proposes a statistical design of experiments approach that will enhance the quantitative aspects of the risk assessment exercise and will make risk assessments smarter, more precise and more efficient. Specifically, our paper demonstrates that a Plackett-Burman design can be used to: (a) identify the subset of security controls that are critical to the enterprise; (b) determine the configuration of these controls; and (c) quantitatively analyze the impact of security enhancements. This paper expands on our previous research by applying statistical models at a macro security architecture level as opposed to determining parameters for individual controls.