gebhart/patrepeval huggingface dataset:
Color image quality metric S-CIELAB and its application on halftone texture visibility (2002)

We describe experimental tests of a spatial extension to the CIELAB color metric for measuring color reproduction errors of digital images. The standard CIELAB /spl Delta/E metric is suitable for use on large uniform color targets, but not on images, because color sensitivity changes as a function of spatial pattern. The S-CIELAB extension includes a spatial processing step, prior to the CIELAB /spl Delta/E calculation, so that the results correspond better to color difference perception by the human eye. The S-CIELAB metric was used to predict texture visibility of printed halftone patterns. The results correlate with perceptual data better than standard CIELAB and point the way to various improvements.
Association between high concentrations of Mr 52,000 cathepsin D and poor prognosis in primary human breast cancer. (1989)

The Mr 52,000 cathepsin D is the precursor of a lysosomal protease secreted in excess by breast cancer cells. This protease can degrade extracellular matrices and proteoglycans and is induced by estrogens in estrogen receptor-positive breast cancer cell lines. In a 4- to 6-yr retrospective cohort study, the concentration of the total cathepsin D (precursor plus intermediate and mature chains) was assayed in cytosols of primary tumors from 242 pre/perimenopausal and 154 postmenopausal breast cancer patients in a solid-phase immunoassay using two specific monoclonal antibodies. Patients were initially divided into groups with low, intermediate, or high concentrations of cathepsin D corresponding to the quartiles of the overall distribution. Using these groupings, the level of Mr 52,000 cathepsin D was not significantly associated with the recognized prognostic factors of age, lymph node involvement, tumor size, and/or grade of anaplasia. A significant association was found between cathepsin D concentrations and estrogen receptor status only among pre/perimenopausal patients. Receptor-positive tumors (greater than or equal to 10 fmol of estrogen receptor/mg of cytosol protein) had a significantly greater proportion of patients with high Mr 52,000 cathepsin D concentrations. Patients with high Mr 52,000 cathepsin D concentrations (greater than 78 pmol/mg for pre/perimenopausal and greater than 24 for postmenopausal patients) have shorter recurrence-free survival (P = 0.06 for pre/peri- and P = 0.039 for postmenopausal patients) and have a trend toward shorter overall survival (P = 0.30 and P = 0.089 for pre/peri- and postmenopausal groups, respectively). In multivariate analysis, Mr 52,000 cathepsin D status was found to be an independent prognostic factor for recurrence-free survival of about the same import as lymph node status for both menopausal groups. This first retrospective study demonstrates that the level of Mr 52,000 cathepsin D in cytosol of primary breast cancer biopsies is an independent prognostic factor in predicting relapses in both pre/peri- and postmenopausal patients.
Smart Contracts in the Cloud (2022)

Abstract The emergence of crypto currencies such as Bitcoin and Ethereum have shown the value in decentralized technologies. The idea of having 24/7 access to programmable money peaked the interest in the field, and as a by-product, came the realization that the same core technologies that enable programmable dog money, can enable highly-available DNS services, highly-available storage services, 24/7 asset exchanges, and peer-to-peer marketplaces to name a few. This paper explores the use of smart contracts in multi-cloud environments in order to facilitate business processes across multiple providers speaking different languages in terms of policies, best practices, APIs, and SLAs.
A Non-Parametric Bayesian Approach to Spike Sorting (2006)

In this work we present and apply infinite Gaussian mixture modeling, a non-parametric Bayesian method, to the problem of spike sorting. As this approach is Bayesian, it allows us to integrate prior knowledge about the problem in a principled way. Because it is non-parametric we are able to avoid model selection, a difficult problem that most current spike sorting methods do not address. We compare this approach to using penalized log likelihood to select the best from multiple finite mixture models trained by expectation maximization. We show favorable offline sorting results on real data and discuss ways to extend our model to online applications
A MULTI-INSTITUTIONAL COHORT OF ACTIVE SURVEILLANCE FOR LOW-RISK LOCALIZED PROSTATE CANCER (2008)

You have accessJournal of Urology1 Apr 2008A MULTI-INSTITUTIONAL COHORT OF ACTIVE SURVEILLANCE FOR LOW-RISK LOCALIZED PROSTATE CANCER Scott E Eggener, Alexander Mueller, Ryan K Berglund, Robert Abouassaly, Chris Zappavigna, Cindy T Soloway, Mark S Soloway, J Stephen Jones, Eric A Klein, Larry Goldenberg, Peter T Scardino, James A Eastham, and Bertrand D Guillonneau Scott E EggenerScott E Eggener More articles by this author , Alexander MuellerAlexander Mueller More articles by this author , Ryan K BerglundRyan K Berglund More articles by this author , Robert AbouassalyRobert Abouassaly More articles by this author , Chris ZappavignaChris Zappavigna More articles by this author , Cindy T SolowayCindy T Soloway More articles by this author , Mark S SolowayMark S Soloway More articles by this author , J Stephen JonesJ Stephen Jones More articles by this author , Eric A KleinEric A Klein More articles by this author , Larry GoldenbergLarry Goldenberg More articles by this author , Peter T ScardinoPeter T Scardino More articles by this author , James A EasthamJames A Eastham More articles by this author , and Bertrand D GuillonneauBertrand D Guillonneau More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(08)60191-3AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "A MULTI-INSTITUTIONAL COHORT OF ACTIVE SURVEILLANCE FOR LOW-RISK LOCALIZED PROSTATE CANCER." The Journal of Urology, 179(4S), p. 64 © 2008 by American Urological AssociationFiguresReferencesRelatedDetails Volume 179Issue 4SApril 2008Page: 64 Advertisement Copyright & Permissions© 2008 by American Urological AssociationMetricsAuthor Information Scott E Eggener More articles by this author Alexander Mueller More articles by this author Ryan K Berglund More articles by this author Robert Abouassaly More articles by this author Chris Zappavigna More articles by this author Cindy T Soloway More articles by this author Mark S Soloway More articles by this author J Stephen Jones More articles by this author Eric A Klein More articles by this author Larry Goldenberg More articles by this author Peter T Scardino More articles by this author James A Eastham More articles by this author Bertrand D Guillonneau More articles by this author Expand All Advertisement PDF downloadLoading ...
Rotatory contracture of the forearm. (1980)

We saw seven patients with an idiopathic progressive loss of rotation of the forearm, occurring primarily during adolescence and manifested principally by a gradual loss of supination. There were secondary developmental abnormalities of the radial head and of the ulna (distal bowing) in four patients. Six surgical procedures were performed on five of the seven patients, consisting of combinations of sectioning of the quadrate ligament, release of the interosseous membrane, and ostecotomy and compression-plate fixation of the distal end of the ulna. There was functional improvement in four patients. Release of the quadrate ligament provided the greatest improvement, but that release alone was of minimum value. We concluded that a contracted quadrate ligament may be an important deterrent to supination of the forearm, but distortion of the radial head, curvature of the ulna, and contracted soft tissues in the interosseus space and distal radio-ulnar joint also are contributory factors.
Exploring Ultrafast Photoswitching Pathways in RbMnFe Prussian Blue Analogue (2021)

Abstract We study by femtosecond optical pump‐probe spectroscopy the photoinduced charge transfer (CT) in the RbMnFe Prussian blue analogue. Previous studies evidenced the local nature of the photoinduced Mn III Fe II → Mn II Fe III process, occurring within less than 1 ps. Here we show experimentally that two photoswitching pathways exist, depending on the excitation pump wavelength, which is confirmed by band structure calculations. Photoexcitation of α spins corresponds to the Mn(d‐d) band, which drives reverse Jahn–Teller distortion through the population of antibonding Mn‐N orbitals, and induces CT within ≈190 fs. The process launches coherent lattice torsion during the self‐trapping of the CT small‐polaron. Photoexcitation of β spins drives intervalence Fe→Mn CT towards non‐bonding states and results in a slower dynamic.
Identification of 4,5-Dihydro-1H-pyrazolo[4,3-h]quinazoline Derivatives as a New Class of Orally and Selective Polo-Like Kinase 1 Inhibitors (2010)

Polo-like kinase 1 (Plk1) is a fundamental regulator of mitotic progression whose overexpression is often associated with oncogenesis and therefore is recognized as an attractive therapeutic target in the treatment of proliferative diseases. Here we discuss the structure-activity relationship of the 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline class of compounds that emerged from a high throughput screening (HTS) campaign as potent inhibitors of Plk1 kinase. Furthermore, we describe the discovery of 49, 8-{[2-methoxy-5-(4-methylpiperazin-1-yl)phenyl]amino}-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide, as a highly potent and specific ATP mimetic inhibitor of Plk1 (IC(50) = 0.007 microM) as well as its crystal structure in complex with the methylated Plk1(36-345) construct. Compound 49 was active in cell proliferation against different tumor cell lines with IC(50) values in the submicromolar range and active in vivo in the HCT116 xenograft model where it showed 82% tumor growth inhibition after repeated oral administration.
Human jobs and computer interfaces : proceedings of the IFIP WG 9.1 Working Conference on Human Jobs and Computer Interfaces, Tampere, Finland, 26-28 June, 1991 (1991)

Jobs and Interfaces. Some Confusions at the Interface: Re-Conceptualizing the Problem (K. Kuutti, L.J. Bannon). Discussant's Note (K.T. Ryan). Industrial Interface Design. Human-Computer Interface in Computer- Aided Control Systems Design (M. Oit). Interfaces in a Flexible Manufacturing System - A Case Study (M. Vartiainen, H. Tiitnen, V. Teikari). Discussant's Note (Risto Suitiala). Interfaces and Special Needs. A Computer Interface for Lawyers (E. Wilson). Design Considerations for Microcomputer Based Applications for the Blind (K.P. Durre, K.W. Glander). Office Applications. Human Factors Issues in the Electronic Newsroom: A Briefing Guide for Media Managers (D.L. Day). The Formalization of Activity Requirements in an Insurance Office (V. Ruohomaki, M. Vartiainen). Computerization and the Construction of New Qualifications in the Context of Product and Process Innovation in the Banking Sector (D.-G. Tremblay). Chairman's Summary (S. Hagglund). Feedback and Cooperation. Computerized Feedback Effects on Feedback Seeking, Performance and Motivation (A.N. Kluger, S. Adler, C. Fay). Building Expectations from Context in On- line Conferencing: A Review (J.C. McCarthy, V. C. Miles, A.F. Monk, M.D. Harrison). Discussant's Note (P. Sorgaard). Organisational Change. Groupwork from a Personal Viewpoint (H. Ishibashi, T. Toyofuku, K. Tanaka, Y. Goto). Electronic Mail & Post Modern Organisation (M. Robinson). Dependencies in Research on User Controlled Information Systems Development (S. Friis). Figure-Ground Reversal in Systems Development and Implementation: From HCI to OSI (D.A. Buchanan, Invited Speaker). Learning and Hypermedia. As We May Learn: Training With Multimedia (A. Vainio-Larsson). An Environment for Evaluating Browsing in Hypermedia Systems (P.L. Loo, T.M. Chung). Discussant's Note (P. Hietala). Developmental Work Research: Reconstructing Expertise through Expansive Learning (Y. Engestrom, Invited Speaker).
Neuronal surface P antigen (NSPA) modulates postsynaptic NMDAR stability through ubiquitination of tyrosine phosphatase PTPMEG (2020)

NSPA contributes to hippocampal plasticity and memory processes ensuring appropriate levels of adult neurogenesis and PSD-located NMDAR. PTPMEG qualifies as NSPA ubiquitination substrate that regulates Tyr phosphorylation-dependent NMDAR stability at PSDs. The NSPA/PTPMEG pathway emerges as a new regulator of glutamatergic transmission and plasticity and may provide mechanistic clues and therapeutic opportunities for anti-P-mediated pathogenicity in SLE, a still unmet need.
ChemInform Abstract: GENERAL METHOD FOR THE SYNTHESIS OF (N.3.3)PROPELLANES, N ≥ 3 (1978)

Abstract Reaktion der alicyclischen Dione (II) mit dem Diester (I) liefert die Propellandiontetraester (III).
A CARP-1 functional mimetic loaded vitamin E-TPGS micellar nano-formulation for inhibition of renal cell carcinoma (2017)

Current treatments for Renal Cell Carcinoma (RCC) include a combination of surgery, targeted therapy, and immunotherapy. Emergence of resistant RCCs contributes to failure of drugs and poor prognosis, and thus warrants development of new and improved treatment options for RCCs. Here we generated and characterized RCC cells that are resistant to Everolimus, a frontline mToR-targeted therapy, and tested whether our novel class of CARP-1 functional mimetic (CFM) compounds inhibit parental and Everolimus-resistant RCC cells. CFMs inhibited RCC cell viability in a dose-dependent manner that was comparable to Everolimus treatments. The GI<sub>50</sub> dose of Everolimus for parental A498 cells was ∼1.2μM while it was <0.02μM for the parental UOK262 and UOK268 cells. The GI<sub>50</sub> dose for Everolimus-resistant A498, UOK262, and UOK268 cells were ≥10.0μM, 1.8-7.0μM, and 7.0-≥10.0μM, respectively. CFM-4 and its novel analog CFM-4.16 inhibited viabilities of Everolimus resistant RCC cells albeit CFM-4.16 was more effective than CFM-4. CFM-dependent loss of RCC cell viabilities was due in part to reduced cyclin B1 levels, activation of pro-apoptotic, stress-activated protein kinases (SAPKs), and apoptosis. CFM-4.16 suppressed growth of resistant RCC cells in three-dimensional suspension cultures. However, CFMs are hydrophobic and their intravenous administration and dose escalation for in-vivo studies remain challenging. In this study, we encapsulated CFM-4.16 in Vitamin-E TPGS-based- nanomicelles that resulted in its water-soluble formulation with higher CFM-4.16 loading (30% w/w). This CFM-4.16 formulation inhibited viability of parental and Everolimus-resistant RCC cells <i>in vitro</i>, and suppressed growth of parental A498 RCC-cell-derived xenografts in part by stimulating apoptosis. These findings portent promising therapeutic potential of CFM-4.16 for treatment of RCCs.
From Thin Relaxed SiGe Buffer Layers to Strained Silicon Directly on Oxide (2006)

Thin relaxed SiGe buffer layers with Ge contents of 23at% and 26at% and thicknesses between 150 to 180 nm on Si(100) terminated with 6 nm Si were made by He ion implantation and annealing. Subsequent overgrowth of the thin buffers with thin strained Si cap layers with SiGe and strained Si reduced the threading dislocation and pile-up densities significantly. Best results were achieved for high temperature SiGe overgrowth with a thickness of 200nm and Ge contents lower than the effective Ge content of the buffer. Threading dislocation densities as low as 1x105 cm -2 and dislocation pile-up densities of 10 cm -1 were determined. Strained silicon on insulator wafers were produced by wafer bonding. Wafer splitting was done by H ion implantation and annealing. The strain of the layers was measured by Raman spectroscopy revealing a strain of 0.66% in the tensile strained Si on the partially relaxed Si 0.77 Ge 0.23 buffers.
Organocatalytic Ring-Opening Polymerization of Trimethylene Carbonate To Yield a Biodegradable Polycarbonate (2014)

In this laboratory experiment, students work in pairs to synthesize a simple aliphatic polycarbonate via ring-opening polymerization of trimethylene carbonate using 1,8-diazabicyclo[5.4.0]undec-7-ene and thiourea as organocatalysts. Following polymer isolation, students cool the material in a dry ice/acetone bath to observe its glass-transition behavior. This experiment is convenient to perform under teaching laboratory conditions and reinforces key concepts learned in second-year undergraduate organic chemistry, for example, nucleophilic acyl substitution, transesterification reactions, and Lewis acidity–basicity. Additionally, the experiment introduces students to polymer chemistry, heterocycles, materials science, and green chemistry. It also covers interesting concepts that are less frequently encountered at the undergraduate level such as biomimetic chemistry, bifunctional catalysis, and polymer–glass transitions.
Forkhead Transcription Factors and Cardiovascular Biology (2008)

The Forkhead family of transcription factors modulates a wide variety of cellular functions in cardiovascular tissues. In this review article, we discuss recent advances in our understanding of regulation provided by the forkhead factors in cardiac myocytes and vascular cells.
Effect of interleukin-6 receptor blockage on renal injury in apolipoprotein E-deficient mice (2009)

Hyperlipidemia has been demonstrated to be associated with renal disease, yet the mechanism of renal injury is still poorly understood. Inflammation that occurs with the hyperlipidemia has been considered to play an important role in development of glomerular injury. In the present study, we investigated the role of interleukin-6 (IL-6), a key inflammatory molecule, on renal injury in apolipoprotein E-deficient (ApoE(-/-)) mice with severe hypercholesterolemia. The 6-wk-old mice were fed a high-fat diet and administered weekly rat anti-IL-6 receptor monoclonal antibody (MR16-1), control rat IgG, or saline for a total of 4 wk. We examined histopathological changes in the kidney and urinary excretion of protein and albumin. Saline- and IgG-treated mice showed remarkable proteinuria at 10 wk of age, whereas MR16-1-treated mice exhibited significantly lower levels. Renal histopathology of saline- and IgG-treated mice revealed striking lipid deposits and foam cells in the glomerular tuft, juxtaglomerular area, and arteriolar wall along with range of mesangial cell proliferation and matrix expansion. Notably, the severity of lipid deposits and mesangial cell proliferation were significantly reduced in MR16-1-treated mice. Immunohistochemistry demonstrated that mesangial IL-6 expression was dramatically reduced in MR16-1-treated mice compared with IgG-treated mice. Blocking the IL-6 receptor prevented progression of proteinuria and renal lipid deposit, as well as the mesangial cell proliferation associated with severe hyperlipoproteinemia. These results clearly demonstrate that IL-6 plays an essential role in the pathogenesis of hyperlipidemia-induced glomerular injury in ApoE(-/-) mice and suggests the usefulness of anti-IL-6 receptor antibody in treatments for hyperlipidemia-induced organ damage.
The Deforestation of L2 (2016)

A major staple of layer 2 has long been the combination of flood-and-learn Ethernet switches with some variant of the Spanning Tree Protocol. However, STP has significant shortcomings -- chiefly, that it throws away network capacity by removing links, and that it can be relatively slow to reconverge after topology changes. In recent years, attempts to rectify these shortcomings have been made by either making L2 look more like L3 (notably TRILL and SPB, which both incorporate L3-like routing) or by replacing L2 switches with "L3 switching" hardware and extending IP all the way to the host. In this paper, we examine an alternate point in the L2 design space, which is simple (in that it is a single data plane mechanism with no separate control plane), converges quickly, delivers packets during convergence, utilizes all available links, and can be extended to support both equal-cost multipath and efficient multicast.
Inhibition of HIV Infection by Caffeoylquinic Acid Derivatives (1993)

The caffeoylquinic acids 3,4,5-tri-O-caffeoylquinic acid (1) and 4,5-di-O-caffeoylquinic acid (2), as well as caffeic acid (4) and synapoic acid (5) were isolated from the plant Securidaka longipedunculata (polygalaceae). 1 exhibited a greater selective inhibition of HIV replication than 2 which had an anti-HIV activity similar to that of 3,4,5-tri-O-galloylquinic acid (3), isolated from Guiera senegalensis (combretaceae); 4 and 5 were ineffective and the structurally related compound rosmarinic acid (6) had only slight anti-HIV activity. Studies of the actions of these compounds suggest that inhibition of the viral reverse transcriptase in vitro is non-specific and that they act by specific binding to gp120 which prevents its interaction with CD4 on T-lymphocytes and thus inactivates virus infectivity.
Coupled-wave analysis for photonic-crystal surface-emitting lasers on air holes with arbitrary sidewalls (2011)

The coupled-wave theory (CWT) is extended to a photonic crystal structure with arbitrary sidewalls, and a simple, fast, and effective model for the quantitatively analysis of the radiative characteristics of two-dimensional (2D) photonic-crystal surface-emitting lasers (PC-SELs) has been developed. For illustrating complicated coupling effects accurately, sufficient numbers of waves are included in the formulation, by considering their vertical field profiles. The radiation of band-edge modes is analyzed for two in-plane air-hole geometries, in the case of two types of sidewalls: i.e. "tapered case" and "tilted case." The results of CWT analysis agree well with the results of finite-difference time-domain (FDTD) numerical simulation. From the analytical solutions of the CWT, the symmetry properties of the band-edge modes are investigated. In-plane asymmetry of the air holes is crucial for achieving high output power because it causes partial constructive interference. Asymmetric air holes and tilted sidewalls help in inducing in-plane asymmetries. By breaking the symmetries with respect to the two orthogonal symmetric axes of the band-edge modes, the two factors can be tuned independently, so that the radiation power is enhanced while preserving the mode selectivity performance. Finally, top-down reactive ion etching (RIE) approach is suggested for the fabrication of such a structure.
Effects of recombinant Clara cell secretory protein (rhCC10) on inflammatory-related matrix metalloproteinase activity in a preterm lamb model of neonatal respiratory distress (2006)

These data suggest that improved lung function in the surfactant-treated preterm lamb following intratracheal rhCC10 may be related to the reduction of proteolytic activity of MMP-7.
Search Driven Analysis of Heterogeneous XML Data (2009)

Analytical processing on XML repositories is usually enabled by designing complex data transformations that shred the documents into a common data warehousing schema. This can be very timeconsuming and costly, especially if the underlying XML data has a lot of variety in structure, and only a subset of attributes constitutes meaningful dimensions and facts. Today, there is no tool to explore an XML data set, discover interesting attributes, dimensions and facts, and rapidly prototype an OLAP solution. In this paper, we propose a system, called SEDA 1, that enables users to start with simple keyword-style querying, and interactively refine the query based on result summaries. SEDA then maps query results onto a set of known, or newly created, facts and dimensions, and derives a star schema and its instantiation to be fed into an offthe-shelf OLAP tool, for further analysis. 1.