gebhart/patrepeval huggingface dataset:
Tumor hypoxia modulates podoplanin/CCL21 interactions in CCR7+ NK cell recruitment and CCR7+ tumor cell mobilization (2017)

Podoplanin (PDPN), an O-glycosylated, transmembrane, mucin-type glycoprotein, is expressed by cancer associated fibroblasts (CAFs). In malignant transformation, PDPN is subjected to changes and its role is yet to be established. Here we show that it is involved in modulating the activity of the CCL21/CCR7 chemokine/receptor axis in a hypoxia-dependent manner. In the present model, breast cancer MDA-MB-231 cells and NKL3 cells express the surface CCR7 receptor for CCL21 chemokine which is a potent chemoattractant able to bind to PDPN. The impact of the CCL21/CCR7 axis in the molecular mechanism of the adhesion of NKL3 cells and of MDA-MB-231 breast cancer cells was reduced in a hypoxic tumor environment. In addition to its known effect on migration, CCL21/CCR7 interaction was shown to allow NK cell adhesion to endothelial cells (ECs) and its reduction by hypoxia. A PDPN expressing model of CAFs made it possible to demonstrate the same CCL21/CCR7 axis involvement in the tumor cells to CAFs recognition mechanism through PDPN binding of CCL21. PDPN was induced by hypoxia and its overexpression undergoes a reduction of adhesion, making it an anti-adhesion molecule in the absence of CCL21, in the tumor. CCL21/CCR7 modulated NK cells/ECs and MDA-MB-231 cells/CAF PDPN-dependent interactions were further shown to be linked to hypoxia-dependent microRNAs as miRs: miR-210 and specifically miR-21, miR-29b which influence PDPN expression.
Modeling of BWR for Neutron and Gamma Fields Using PENTRAN™ (2001)

We have developed a three-dimensional (3-D) model of a BWR to determine the radiation fields (neutron and gamma) throughout the core shroud in order to investigate the role of irradiation on the observed cracks. To handle large computational requirements, we have used the PENTRAN™ (Parallel Environment Neutral-particle TRANsport) 3-D, parallel SN code. Coupled neutron and gamma (67-group) calculations have been performed using S8 level symmetric quadrature set and BUGLE-96 cross-section library with P3 anisotropic scattering order. We have compared 3-D results with two-dimensional (2-D) results and concluded that 3-D calculations are necessary. In order to verify the 3-D multigroup PENTRAN™ results, we have performed 3-D multigroup TORT and continuous-energy A3MCNP™ (Automated Adjoint Accelerated MCNP) calculations and have obtained very good agreement. Timing studies have demonstrated that PENTRAN™ is highly scalable (∼90%).
Alternative Network Architectures for Supporting Communications from the International Space Station (2002)

In order to support the communications needs of the International Space Station (ISS), alternative communications architectures to provide broadband support need to be considered. We address three communications options and evaluate an architecture for the direct to ground option, which could serve as an intermediary solution to satisfy near term communications needs of commercial experiments and payloads on the ISS and overcome certain limitations of the current ISS communications infrastructure. We focus on a particular user’s requirements, and examine the system’s communications links, and coverage availability. These parameters, along with high-level cost estimates, are compared to using commercial relay satellites, and an enhanced TDRSS. The direct to ground option is viable for store-andforward applications and cost comparable to commercial constellations, but TDRSS is the choice for realtime or continuous data applications.
The role of PI3-Kinase signalling in immunomodulation by a protective innate defence regulator peptide (135.6) (2009)

Abstract The rise of antibiotic resistance has lead to the search for new therapeutics against bacterial infections. Innate defence regulators (IDRs), synthetic versions of natural host defence peptides, are being developed as anti-infective agents due to their immunomodulatory properties. HDPs have been shown to suppress infections by boosting leukocyte recruitment, while limiting harmful inflammation. To optimize the IDR regulatory function, we developed peptide 1002, a bactenecin derivative, by screening a peptide library for enhanced leukocyte chemoattractants induction in human blood mononuclear cells (hBMC). 1002 enhanced protection in a Staphylococcus aureus murine infection model, correlating with increased chemokine production and leukocyte recruitment. 1002 also suppressed inflammatory cytokine production by lipopolysaccharide-stimulated hBMC. IDRs are being deciphered to assist in their development as therapeutics. We found that 1002 regulation is dependent on the PI3-Kinase pathway, a signal cascade that regulates immune and inflammatory responses. PI3-K inhibition abrogated 1002-mediated chemokine induction and reduced its anti-inflammatory properties. 1002 influence on PI3-K signalling was confirmed by examining responses of pathway elements and by systems biology microarray analysis of the immune network by InnateDB. Understanding the mechanisms of IDR immune regulation via PI3-K modulation will aid in their development as novel anti-infective agents. This work was supported by Genome BC and Genome Prairie for the Pathogenomics of Innate Immunity Research Program, and by FNIH and CIHR through the Grand Challenges in Global Health Initiative.
Related Article from Are Short Telomeres Hallmarks of Cancer Recurrence? (2023)

Related Article from Are Short Telomeres Hallmarks of Cancer Recurrence?
Nonpeptide αvβ3 Antagonists: Identification of Potent, Chain‐Shortened 7‐Oxo RGD Mimetics. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Development of a Six-Axis Force/Moment Sensor Attached to a Prosthetic Limb for the Unrestrained Gait Measurement (2011)

Since the number of trans-femoral amputees has increased by industrial or traffic accidents in modern society, the demand for a prosthetic limb has also increased year after year. In this case, those amputees must regain moving pattern by refined efficient gait training using load conditions on a prosthetic limb as quantitative evaluation indices. However, conventional prosthetic gait training systems cannot measure long continuous walking motions under a wide range of environmental conditions. In this paper, a novel six-axis force/moment sensor, which is attached to a prosthetic limb for the unrestrained gait measurement, is developed. As a result of applying structural optimization techniques using response surface method and desirability function to this sensor by finite element analysis, optimum design variables to make the effect of interference components much smaller are obtained. Finally, characteristics test using the production model by applying optimum design variables is performed and the effectiveness of the developed sensor is validated.
Dynamic-agents for dynamic service provisioning (1998)

We claim that a dynamic-agent infrastructure can provide a shift from static distributed computing to dynamic distributed computing, and we have developed such an infrastructure to realize such a shift. We shall show its impact on software engineering through a comparison with other distributed object-oriented systems such as CORBA and DCOM, and demonstrate its value in highly dynamic system integration and service provisioning. The infrastructure is Java-based, light-weight, and extensible. It differs from other agent platforms and client/server infrastructures in its support of dynamic behavior modification of agents. A dynamic-agent is not designed to have a fixed set of predefined functions but instead, to carry application-specific actions, which can be loaded and modified on theory. This allows a dynamic-agent to adjust its capability for accommodating environment and requirement changes, and play different roles across multiple applications. The above features are supported by the light-weight, built-in management facilities of dynamic-agents, which can be commonly used by the "carried" application programs to communicate, manage resources and modify their problem solving capabilities. Therefore, the proposed infrastructure allows application-specific multi-agent systems to be developed easily on top of it, provides "nuts and bolts" for run-time system integration, and supports dynamic service construction, modification and movement. A prototype has been developed at HP Labs and made available to several external research groups.
Remembering Prof. Edmund R. Malinowski, 1932–2020 Professor of Chemistry, 1963–1997 Stevens Institute of Technology (2023)

One of the great pioneers of chemometrics, Prof. Edmund R. Malinowski, passed away in February 2020. Contributors to this special issue are proud to recognize and honor the pioneering work of Professor Malinowski. It is my special privilege to write this remembrance of him. Prof. Malinowski had an enormous impact on the field of chemometrics, having published over 70 papers and most notably the pioneering book “Factor Analysis in Chemistry” in 1980. The timely introduction of this topic and his clear writing style in a language that chemists could understand made this book a valuable educational tool for the budding chemometrics community. Prof. Malinowski's clear writing style can be observed throughout all his research publications. Further details about his career, his awards, and his impact on the field are well summarized in a 1999 editorial.1 His last PhD student, Kathleen Schostack, described Prof. Malinowski as “thoughtful and soft-spoken; very much old school, a gentleman and a gentle man.” I wholeheartedly concur. Prof. Malinowski was always quick to acknowledge and recognize the work of others, and I was one of the beneficiaries of this particular kindness of him. It is my pleasure to share some of my remembrances about Prof Malinowski and the impact he had on my career. In 1982, fresh out of my PhD, not having been trained in chemometrics, I discovered Prof. Malinowski's 1980 book, “Factor Analysis in Chemistry” and read it cover to cover. I was already interested in mathematical methods for resolving overlapping GC/MS or LC/UV-Vis peaks. The clear writing style and detailed attention to the mathematics of factor analysis in this book laid a great foundation for me, and by 1984, I had written a draft of my first chemometrics paper.2 Being very early in my career, the faculty at ECU asked me to organize a half-day symposium on the topic of chemometrics. I invited Tom Isenhour and Ed Malinowski, and to my great surprise, both agreed to come. I remember picking Ed up at the airport the night before the symposium and nervously handing him a draft of my first chemometrics paper. The next morning in his introductory remarks to the faculty at ECU he stated with amazement that “One of your very own faculty members gave me a draft paper yesterday that for the first time shows a curve resolution method using factor analysis to resolve three or more overlapping peaks, whereas until now it was believed that only two peaks could be resolved.” He continued to cite this work and the work of other early-career chemometricians in his conference presentations and publications. By using his name recognition and standing in the field, he generously promoted early-career chemometricians. In many ways, Prof. Edmund R. Malinowski was a Renaissance Man like others from this era. His retirement and later his death signified the end of an era, and we are all the poorer for it. The peer review history for this article is available at https://publons.com/publon/10.1002/cem.3466. N/A.
Development of a candidate secondary reference procedure (immunoassay based measurement procedure of higher metrological order) for cardiac troponin I: I. Antibody characterization and preliminary validation (2010)

In this study, the first steps in the development of a secondary reference measurement procedure (RMP) 'higher metrological order measurement procedure' to support the cardiac troponin I (cTnI) standardization initiative is described. The RMP should be used to assign values to serum-based secondary reference materials (RMs) without analytical artifacts causing bias. A multiplexed bead-based assay and sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) were used to identify the optimum monoclonal antibody pair (clones 560 and 19C7) for the RMP. Using these antibodies, an ELISA-based procedure was developed to accurately measure the main cTnI forms present in blood. The proposed RMP appears to show no bias when tested on samples containing various troponin complexes, phosphorylated and dephosphorylated forms, and heparin. The candidate assay displayed suitable linearity and sensitivity (limit of detection, 0.052 μg/L) for the measurement of the proposed cTnI secondary RMs. Preliminary comparison data on patient samples with a commercial cTnI assay are also provided to support the suitability of RMP for value assignment to RMs. Full validation and final assessment of the RMP will be performed through transferability and inter-comparison studies.
Bounds on the ergodic capacity of training-based multiple-antenna systems (2005)

Multiple-antenna concepts for wireless communication systems promise high spectral efficiencies by proper exploitation of the randomness in multipath propagation. In this paper, we investigate the impact of channel uncertainty caused by channel estimation errors on the capacity of Rayleigh and Ricean block-fading channels. We consider a training-based multiple-antenna system that reserves a portion of time to sound the channel. The training symbols are used to estimate the channel state information (CSI) at the receiver by means of an arbitrary linear estimation filter. No CSI is assumed at the transmitter. We present an equivalent system model for training-based multiple-antenna systems, which specifies the channel by the estimated (and hence, known) channel coefficients and an uncorrelated, data-dependent noise. Based on this equivalent model, which includes the special cases of perfect CSI and no CSI, we derive upper and lower bounds on the maximum instantaneous mutual information and the ergodic capacity, and extend previous results to arbitrary (and possibly mismatched) linear channel estimators and to correlated Ricean fading
A polynomial-time optimal synchronous bandwidth allocation scheme for the timed-token MAC protocol (2002)

Numerous methods have been proposed to integrate real-time and non-real-time services of the timed-token medium access control (MAC) protocol. One of the key issues in tailoring the timed-token MAC protocol for real-time applications is the synchronous bandwidth allocation (SEA) problem whose objective is to meet both the protocol and deadline constraints. Several non-optimal local SEA schemes and an optimal global scheme have been proposed previously. Local SEA schemes use only information available locally to each node, and are thus preferred to global schemes because of their lower network-management overhead. Unfortunately it has been formally proved in Han et al. (1995) that there does not exist any optimal local SEA scheme. Chen et al. [1992] proposed the only-known optimal global SEA scheme which is based on an iterative approach. However, their algorithm may not terminate theoretically. The present authors give an optimal global SEA scheme of polynomial-time worst-case complexity.
Completion of the Total Synthesis of Several Bioactive Sarpagine/Macroline Alkaloids including the Important NF-κB Inhibitor N4-Methyltalpinine (2022)

The unification of the general synthetic strategy regarding the important and emerging group of C-19 methyl-substituted sarpagine/macroline alkaloids has culminated in the completion of the total synthesis of several bioactive alkaloids. Key transformations include an ACE-Cl mediated late-stage N(4)-demethylation and an anhydrous acid-mediated intramolecular quaternary hemiaminal formation between a tertiary amine and an aldehyde function to allow efficient access to several biologically important alkaloids from this group. Herein, the enantiospecific total synthesis of the first known sarpagine/macroline alkaloid with NF-κB inhibitory activity, N(4)-methyltalpinine (as a chloride salt), as well as the anticancer alkaloids talpinine, <i>O</i>-acetyltalpinine, and macrocarpines F-G, are described.
Multiple Access Management Services Multi-Access Management Services (MAMS) (2020)

In multiconnectivity scenarios, the end-user devices can
simultaneously connect to multiple networks based on different access
technologies and network architectures like WiFi, LTE, DSL. Both the
quality of experience of the users and the overall network utilization
and efficiency may be improved through the smart selection and
combination of access and core network paths that can dynamically
adapt to changing network conditions. This document presents a unified
problem statement and introduces a solution for managing
multiconnectivity. The solution has been developed by the authors
based on their experiences in multiple standards bodies including the
IETF and 3GPP, but is not an Internet Standard and does not represent
the consensus opinion of the IETF. This document describes the
requirements, solution principles, and an architectural framework that
aims to provide best performance while being easy to implement in a
wide variety of multiconnectivity deployments. It specifies the
protocol multi-access management to: 1) flexibly select the best
combination of access and core network paths for uplink and downlink;
as well as 2) determine the user plane treatment and traffic
distribution over the selected links ensuring network efficiency and
application performance.
Dynamic thermal modelling and analysis of press-pack IGBTs both at component-level and chip-level (2013)

Thermal models are needed when designing power converters for Wind Turbines (WTs) in order to carry out thermal and reliability assessment of certain designs. Usually the thermal models of Insulated Gate Bipolar Transistors (IGBTs) are given in the datasheet in various forms at component-level, not taking into account the thermal distribution among the chips. This is especially relevant in the case of Press-Pack (PP) IGBTs because any non-uniformity of the clamping pressure can affect the chip-level thermal impedances. This happens because the contact thermal resistances in the thermal impedance chains are clamping pressure dependent. In this paper both component-level and chip-level dynamic thermal models for the PP IGBT under investigation are developed. Both models are developed using geometric parameters and material properties of the device. Using the thermal models, the thermal impedance curves under various mechanical clamping conditions are derived. Moreover, the deformation of the internal components of the PP IGBT under operating-like conditions is investigated with the help of the thermal models and the coefficient of thermal expansion (CTE) information.
Relationship of loss of miRNA-296 in the circulation and clinical outcome in patients receiving systemic chemotherapy for metastatic colon cancer. (2012)

e14009 Background: Several studies highlighted the potential for serum microRNA (miRNA) as prognostic and/or predictive markers. We describe an association between miR-296 and outcomes in a phase II trial of sunitinib and capecitabine in first line treatment of patients with metastatic colorectal cancer. Methods: Serum samples were obtained from subjects at (1) Screening (2) Prior to start of study drug (3) Every four weeks while on study. We compared miRNA levels and response to treatment at baseline and at four weeks. Results: Serum from seven patients was used to run miRNA array (382 miRNAs). Among the seven patients, three patients had decrease in the level of miR-296 at 4 weeks (Table). These patients were on the study treatment for a mean duration of 2.5 months (median 1.9). They had a mean survival from the time of diagnosis of 10.5 months (median 10.4) and a mean survival from time of enrollment of 7.5 months (median 8.7). Four patients had increase in the level of miR-296 at 4 weeks. These four patients were on the study treatment for a mean duration of 5 months (median 5). They had a mean survival from the time of diagnosis of 22.8 months (median 22) and a mean survival from study entry of 17.1 months (median 18.3). The duration on study treatment and the difference in survival from diagnosis, between the two groups were statistically significant (p=0 .014 and p=0.0025, respectively). Patients with shorter survival and poor clinical outcome had decrease in the level of miR-296 at four weeks from the start of treatment (0.43 versus 28 for patients with better clinical outcome; p=0.035). Conclusions: In our study, miR-296, served as a predictive and prognostic marker for clinical outcome of patients receiving systemic treatment for advanced colorectal cancer. Further studies are needed to confirm our results in a larger population. [Table: see text]
PHASE I/II CLINICAL TRIAL OF AN ACTIVATED WHOLE TUMOR CELL VACCINE FOLLOWED BY TRANSFER OF IMMUNE T CELLS IN PATIENTS WITH MANTLE CELL LYMPHOMA (2017)

Introduction: We report interim results of a CpG-activated whole tumor cell vaccine for patients with newly diagnosed Mantle Cell Lymphoma (MCL). This phase I/II trial (NCT00490529) had the primary end points of safety and freedom from minimal residual disease (MRD) at 1 year post autologous stem-cell transplant (ASCT). Secondary end points include time to treatment failure (TTF) from initial chemotherapy, overall survival (OS), and T cell immune response. Methods: Prior to treatment, patient-specific vaccines were made by activating freshly collected tumor cells with PF-3512676 (CpG) followed by radiation (200 Gy). Patients with a partial or complete response after standard immunochemotherapy received three subcutaneous injections with the vaccine product together with additional CpG (18 mg). T-cells were collected by leukapheresis after the last vaccine and cryopreserved. The day after an ASCT, the T-cell product was infused and a 4th vaccination was given. A 5th booster vaccination was given ~3 months post ASCT. Blood samples were collected at various time points for measurement of anti-tumor immune responses and for detection of MRD by VDJ high throughput sequencing of blood mononuclear cells (ClonoSeq™). Results: Between April 2008 and August 2016, 65 patients were enrolled and 43 patients have completed ASCT and are included in the safety analysis. The CpG MCL vaccine was well tolerated. The most common toxicity was grade I/II erythematous rash at the injection site (98%), and no unexpected toxicities were seen before or after ASCT. 34 patients are at least 1 year post ASCT and included in the primary analysis. 31 (91%) patients were MRD negative at the previously validated threshold (1 MCL clone per 10,000 input genome equivalents of DNA). MRD negativity at 1-year post ASCT predicted longer subsequent remission duration (p < 0.0001) and survival (p = 0.0021). Lower levels of MRD down to 1 per million were occasionally detected but were not associated with relapse or survival. Median TTF and OS have not been reached (NR) with an average follow-up of 4.91 years. By comparison a contemporaneous cohort of similar patients with MCL who received the same ASCT at our institution, but with no vaccine, have a median TTF of 4.03 years (p = 0.164). Analysis of the vaccine characteristics revealed that patients whose tumor cells demonstrated CpG-induced elevation of PD-L1 had significantly worse TTF (2.4 years vs NR, p = 0.0037) and OS (3.2 years vs NR, p = 0.0042). We also detected tumor-specific CD4+ and CD8+ T cell immune responses following vaccination. Conclusion: The addition of a CpG-activated, autologous tumor cell vaccination and adoptive immune T-cell product to standard therapy for MCL is feasible and safe. At this interim analysis, vaccinated patients had freedom from MRD at 1 year post transplant that surpasses previously reported rates. Keywords: B-cell lymphoma; mantle cell lymphoma (MCL); minimal residual disease (MRD)