gebhart/patrepeval huggingface dataset:
A SOC for multimedia network devices (2003)

Two main aspects of multimedia SoC are addressed in this paper. First, a multiprocessor system employing reconfigurable hardware blocks with coarse and fine grain structures is introduced. It alleviates the tradeoff between computing performance and circuit flexibility for a wide range of applications. Second, a clock generator for synchronous audio and video interfaces is presented. In order to provide high portability and compatibility with the digital design flow it consists of digital standard cells only. Integrated on a 0.25 /spl mu/m CMOS process, the system occupies 25 mm/sup 2/ and operates at 100 MHz. Computation speedup of up to factor 9.7 over stand-alone CPU solutions could be achieved. The clock generator runs at 200 MHz and provides a frequency resolution of 0.06 ppm with an expected output jitter of less than 30 ps; RMS.
Etude du Comportement Energétique de l'Explosif à l'Echelle Moléculaire. Approche Théorique et Expérience TRISP (1995)

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Time-resolved fluorescence measurements using self-pulsing 650-nm laser diodes (2005)

We report on the development of a stroboscopic excitation technique using a self-pulsing laser, and show that it is a feasible method for obtaining fluorescence lifetime information from a biochip format. The self-pulsing lasers described here are versatile devices which have been used for one photon excitation measurements to determine the lifetime of cyanine 5 in water and ethanol. The same devices have been used to develop a technique whereby the emphasis for time-resolution of a lifetime measurement can be transferred to the excitation source from the detector and processing electronics by virtue of the multiple-pulse, variable frequency nature of the laser output.
Genetically engineered NY-ESO-1 specific T cells in HLA-A201+ patients with advanced cancers. (2015)

TPS3102 Background: NY-ESO-1 (CTAG-1B) is a cancer testis antigen associated with spontaneous and vaccine-induced immunity that can lead to improved clinical outcomes. NY-ESO-1 is not expressed in vital tissues, and is expressed in approximately 40% of ovarian, 60% of advanced myeloma, and 70% of synovial sarcoma tumors. Expression is correlated with tumor proliferation and high risk features. A human-derived affinity-optimized TCR that recognizes the NY-ESO-1 derived SLLMWITQC peptide in complex with HLA‐A*0201 (NY-ESOc259) has been generated, and clinically tested as previously described using adoptive T cell transfer with supportive IL-21 Methods: Multiple clinical studies were initiated in HLA-A201+ patients with NY-ESO-1 expressing tumors. NY-ESO-1c259-engineered autologous T-cells are manufactured centrally, using a 12 day commercial-grade closed system, and are administered without supportive IL-2. 40 patients have been infused: 25/26 on a phase I/II study in adults with systemic or multifocal myeloma requiring autologous stem cell transplantation, and who have incompletely responded to prior therapy or have high risk features (NCT01352286); 10/30 on a pilot study in patients ≥4 years old with unresectable, metastatic or recurrent synovial sarcoma (NCT01343043); 5/20 on a phase I study in adults with refractory or platinum resistant ovarian cancer and/or that have received ≥2 lines of chemotherapy (NCT01567891). Pre-infusion lymphodepleting chemotherapy is administered, and varies in intensity across studies. Primary objectives include safety and tolerability. Secondary objectives include evaluation of gene modified cells persistence in blood and tumor biopsies, lineage and functionality of these cells over time, and monitoring for serum cytokine levels and NY-ESO-1 antigen on tumor post infusion. Response assessments are performed using RECIST (sarcoma), IMWR criteria (myeloma), or immune-related response criteria (irRC; ovarian). 1. Robbins PF, Morgan RA, Feldman SA, et al: Tumor Regression in Patients With Metastatic Synovial Cell Sarcoma and Melanoma Using Genetically Engineered Lymphocytes Reactive With NY-ESO-1. Journal of Clinical Oncology 29:917-924, 2011 Clinical trial information: NCT01343043.
THE ELECTION TRANSPORT SYSTEM IN NITROGEN FIXATION BY Azotobacter , I. AZOTOFLAVIN AS AN ELECTRON CARRIER (1969)

A flavoprotein, named azotoflavin, was isolated from an extract of Azotobacter vinelandii cells, which linked the reducing power generated by illuminated spinach chloroplasts to the Azotobacter nitrogen-fixing enzyme complex. The photoreduction of the yellow azotoflavin by chloroplasts produced a stable, free-radical semiquinone, blue in color, with properties similar to those described by other investigators for an Azotobacter flavoprotein of unknown biological function.
Emergenet: robust, rapidly deployable cellular networks (2014)

Cellular phone networks are often paralyzed after a disaster, as damage to fixed infrastructure, loss of power, and increased demand degrade coverage and quality of service. To ensure disaster victims and first responders have access to reliable local and global communication, we propose EmergeNet, a portable, rapidly deployable, small-scale cellular network. In this article, we describe EmergeNet, which addresses the challenges of emergency and disaster areas. EmergeNet provides free voice calling and text messaging within a disaster area, and enables users of unmodified GSM handsets to communicate with the outside world using the Skype VoIP network. We evaluate EmergeNet's ability to provide robust service despite high load, limited bandwidth, and software or hardware failures. EmergeNet is uniquely well suited to providing reliable, fairly allocated voice and text communication in emergency and disaster scenarios.
Thermoplastic composites from curvilinear 3D multi-layer spacer fabrics (2010)

This article reports on the development of thermoplastic composites using innovative curvilinear 3D multi-layer flat knitted spacer fabrics produced by single stage manufacturing. Thermoplastic composites from textile-based, complex-shaped sandwich preforms, for instance, curvilinear-shaped 3D multi-layer spacer fabrics show great potential for lightweight applications. Faster production time and reduction of waste can be achieved by single stage manufacturing of such 3D textile preforms. Spacer-shaped 3D textile preforms were developed using commingled hybrid yarns made of GF and PP filaments. This 3D spacer fabric was consolidated to 3D composite using the developed mechanical tools. In order to predict the mechanical performance of 3D composites, mechanical properties of reinforcement yarns unraveled from 3D spacer fabrics, 2D knit fabrics, and 2D composites using the 2D knit fabrics produced in the same manner as the individual layers of 3D spacer fabrics were studied. The results are promising for applications in high-performance composites.
Manipulation sans contact pour le micro-assemblage: lévitation acoustique (2008)

Micro-assembly is of crucial importance in industry nowadays. Nevertheless, currently applied processes require improvements. Indeed, when dealing with the assembly of submillimetric components, usually neglected surface forces disturb the manipulation task. They are responsible for the component sticking to the gripper, because of downscaling laws. A promising strategy to tackle adhesion consists in working without contact. The present dissertation is focused on contactless handling with acoustic levitation.&lt;p&gt;The advantages of contactless handling, the physical principles suitable for levitation and their applications are detailed. The opportunity for new handling strategies are shown. Acoustic levitation appears as the most fitted principle for micro-assembly. The elements to model acoustic forces are analysed and performances of existing modellings are assessed. A general numerical model of acoustic forces is implemented and theoretically validated with literature benchmarks. A fully automated modular levitator prototype is designed and used to experimentally validate the implemented numerical model. Specific instrumentations and protocols are developed for the acoustic force measurements.&lt;p&gt;The numerical model is finally applied to the real levitator. Modelling results are used to support experimental observations: the optimisation of the levitator resonance, the influence of the reflector shape, the dynamical study of the component oscillations, the stability with lateral centring forces and rotation torques, the component insertion and extraction from the levitator, the effect of pressure harmonics on the acoustic forces, and the manipulation of non spherical components. Acoustic forces are experimentally measured and a very good agreement with the modellings is obtained. Consequently, the implemented simulation tool can successfully be applied to a complex manipulation task with a component of any shape in a real levitator.
Design and analysis of linear distributed MIMO relaying algorithms (2006)

The use of multiple antennas at both ends of a wireless link, also known as multiple-input multiple-output (MIMO) wireless, has been shown to offer significant improvements in the quality of communication in terms of both higher data rates and better reliability at no additional cost of spectrum or power. In this paper, MIMO communication in a wireless network is considered where multiple MIMO source-destination pair terminals simultaneously communicate through a large common set of MIMO relay terminals. With ever increasing demands for tetherless, ubiquitous and high data rate applications, there has been great interest in developing novel decentralised communication methods through distributed relaying techniques to enhance performance and enable more efficient usage of system resources. Distributed MIMO linear relaying techiques are designed that take advantage of local channel state information (CSI) at the relay terminals to simultaneously beamform multiple users&apos; signals to their intended destinations. The merits of distributed MIMO relaying over direct transmissions through the analytical characterisation of the signal-to-interference ratio (SIR) statistics in the high and low signal-to-noise ratio (SNR) regimes are demonstrated and theoretical predictions are verified by numerical simulations. Finally, relay beamforming based on the quantised finite-rate feedback of the channel states is considered and the SIR degradation through Monte-Carlo simulations is quantified.
Kijimicin: an inhibitor of human immunodeficiency virus in acutely and chronically infected cells. (1991)

A new polyether antibiotic, kijimicin (Fig. MI215-NF31}. This agent exhibits high anticoccidial activity. In the present communication, we report its and humanimmunodeficiency virus (HIV) activity in both primary and chronic infection.
Effect of p95HER2/611CTF on the Response to Trastuzumab and Chemotherapy (2014)

Human epidermal growth factor receptor 2 (HER2)-positive breast cancers are currently treated with trastuzumab, an anti-HER2 antibody. About 30% of these tumors express a group of HER2 fragments collectively known as p95HER2. Our previous work indicated that p95HER2-positive tumors are resistant to trastuzumab monotherapy. However, recent results showed that tumors expressing the most active of these fragments, p95HER2/611CTF, respond to trastuzumab plus chemotherapy. To clarify this discrepancy, we analyzed the response to chemotherapy of cell lines transfected with p95HER2/611CTF and patient-derived xenografts (n = 7 mice per group) with different levels of the fragment. All statistical tests were two-sided. p95HER2/611CTF-negative and positive tumors showed different responses to various chemotherapeutic agents, which are particularly effective on p95HER2/611CTF-positive cells. Furthermore, chemotherapy sensitizes p95HER2/611CTF-positive patient-derived xenograft tumors to trastuzumab (mean tumor volume, trastuzumab alone: 906 mm(3), 95% confidence interval = 1274 to 538 mm(3); trastuzumab+doxorubicin: 259 mm(3), 95% confidence interval = 387 to 131 mm(3); P < .001). This sensitization may be related to HER2 stabilization induced by chemotherapy in p95HER2/611CTF-positive cells.
FCAPS in the Business Services Fabric Model (2009)

The emergence of the next generation of computational environment, consisting of interoperable public clouds, private clouds and private infrastructures, will provide on-demand ubiquitous virtual resources. The delivery of business services over these ubiquitous virtual resources requires a reexamination of how these services are managed and delivered to assure appropriate levels of service availability, performance, security and cost. In addition, these business services maybe realized using public and private services that are able to utilize all or restricted types of virtual resources. The focus of this paper is the application to services of the well understood concepts of Fault, Configuration, Accounting, Performance and Security (FCAPS) management introduced in the Telecommunications Management Network (TMN). The paper proposes the incorporation of FCAPS management capabilities at a minimum into all services at a component level to enable end-to-end service management.The FCAPS capabilities are realized through management policy, and managed through collaboration between agents implementing the FCAPS capability; a commonly used subset list of FCAPS capabilities - these can be individually or as a sub-group realized by service agents for incorporation in both managed and management service agents. The model does not mandate a centralized or distributed FCAPS management capability. The model does indicate that the management capabilities are required at every layer of the services environment.
Characterization of the pharmacologic profile of a standardized soy extract in the ovariectomized rat model of menopause: effects on bone, uterus, and lipid profile (2005)

The results of this study demonstrated that the tested extract has an interesting profile of tissue-specific response, in that it is efficacious in preventing experimental osteoporosis without causing stimulation in uterus at doses that are effective in bone.
Band-Selective Carbonyl to Aliphatic Side Chain 13C−13C Distance Measurements in U-13C,15N-Labeled Solid Peptides by Magic Angle Spinning NMR (2004)

We describe three-dimensional magic angle spinning NMR experiments that enable simultaneous band-selective measurement of the multiple distance constraints between carbonyl and side chain carbons in uniformly 13C,15N-labeled peptides. The approaches are designed to circumvent the dipolar truncation and to allow experimental separation of the multiple quantum (MQ) relaxation and dipolar effects. The pulse sequences employ the double quantum (DQ) rotational resonance in the tilted frame (R2TR) to perform selective polarization transfers that reintroduce the 13C'-13Cgamma,delta dipolar interactions. The scheme avoids recoupling of the strongly coupled C'-Calpha and C'-Cbeta spin pairs, therefore minimizing dipolar truncation effects. The experiment is performed in a constant time fashion as a function of the radio frequency irradiation intensity and measures the line shape of the DQ transition. The width and the intensity of this line shape are analyzed in terms of the DQ relaxation and dipolar coupling. The attenuation of the multispin effects in the presence of relaxation enables a two-spin approximation to be employed for the analysis of the experimental data. The systematic error introduced by this approximation is estimated by comparing the results with a three-spin simulation. The contributions of B1-inhomogeneity, CSA orientation effects, and the effects of inhomogeneous line broadening are also estimated. The experiments are demonstrated in model U-13C,15N-labeled peptides, N-acetyl-L-Val-L-Leu and N-formyl-L-Met-L-Leu-L-Phe, where 10 and 6 distances, ranging between 3 and 6 A, were measured, respectively.
Positive Temperature Coefficient of Resistivity in Donor‐Doped BaTiO3 Ceramics derived from Nanocrystals synthesized at Low Temperature (2008)

Small, donor-doped Ba1-xLaxTiO3 nanocrystals are successfully prepared for the first time. These nanocrystals are suitable precursors for small-grain Ba1-xLaxTiO3 ceramics with a sizeable positive temperature coefficient of resistivity (PTCR) that is comparable to that of traditional large-grain ceramics derived from solid-state routes.
Direct measurement of index of refraction in the extreme-ultraviolet wavelength region with a novel interferometer (2002)

To the best of our knowledge, the first direct measurement of the dispersive part of the refractive index is performed at extreme-ultraviolet (EUV) wavelengths, where absorption is higher as compared with hard-x-ray and visible wavelengths. A novel diffractive optical element that combines the functions of a grating and a zone plate is fabricated with Fourier optical techniques and employed here for the first time at EUV/soft-x-ray wavelengths. Both the real and the imaginary parts of the complex refractive indices are measured directly by this technique without recourse to Kramers-Kronig transformations. Data for Al and Ni in the vicinity of their L and M edges, respectively, are presented as first examples of this technique.
BLX‐1028, an orally active small molecules having anti‐adipogenic property, reduces weight gain, fat content and improves glucose tolerance in Diet Induced Obesity model in mice (2006)

BLX‐1028 is a water soluble, orally active, modified amino acid conjugated small molecule with no structural resemblance with any existing anti‐obesity compounds. BLX‐1028 showed a dose dependent inhibition of adipocyte differentiation at 0.1mM (30.4%), 1mM (40.2%) and 10mM (99.2%) concentrations in 3T3‐L1 cells when incubated along with rosiglitazone (1mM), a known PPARy agonist. In Diet Induced Obesity Model (DIO), where obesity was induced in C57BL/6 mice by feeding on a high fat (60% fat) diet, treatment with BLX‐1028 at 5, 50 and 100 mg/kg/day, lowered body weight gain by 40 % in comparison to vehicle treated animals. No significant changes in food and water intake were observed. In a dual‐energy X‐ray absorptiometry (DXA) technique with an image analysis procedure, it showed reduction in body fat content in treatment group compare to vehicle. Oral glucose tolerance test performed on days 0, 30, 60 and 90 showed an improvement in glucose tolerance. No significant changes were observed in cholesterol, triglyceride and free fatty acid levels. Blood serum analysis after 30, 60 and 90 days of treatment revealed that no significant difference in AST and ALT levels. The mechanism of action of BLX‐1028 is currently being investigated. These results combined demonstrate the potential of BLX‐1028 as a novel compound for the treatment of obesity and related disorders.
Self-Assembly and Induced Circular Dichroism in Dendritic Supramolecules with Cholesteric Pendant Groups (2010)

We report on the solid-state structural features of self-assembled chiral supramolecules based on ionic complexation of chiral cholesteric pendant groups with achiral dendritic macromolecules and show that their optical activity exhibits a systematic change in the ultraviolet/visible light (UV-vis) absorption and enhancement in the circular dichroism (CD) signal, indicating the occurrence of supramolecular chirality, also referred to as induced circular dichroism (ICD). We construct a homologous series of complexes by varying systematically from 1 to 3 the generation of dendritic units contained in dendrons, dendrimers, and dendronized polymers. The structural properties of the complexes are investigated by means of small-angle X-ray scattering (SAXS) and transmission electron microscopy (TEM). Depending on the class of dendritic molecule and the generation, lamellar, columnar hexagonal, oblique columnar, and rectangular columnar phases can be found, with a direct correlation among the degrees of freedom of the dendritic macromolecules used and the level of order achieved in the self-assembled solid-state structures. The enhancement of the optical signals of these mesoscopic structures appears to be correlated with their order in the solid state. Complexes with the longest lattice correlation lengths also show the most enhanced CD signals. These results show the unique versatility of dendritic macromolecules as supramolecular templates capable of organizing low molecular weight chiral pendant units into a variety of solid-state structures with amplified optical properties.
Transfer of π-Conjugated Columnar Stacks from Solution to Surfaces (2003)

Three hydrogen-bonded oligo(p-phenylenevinylene)s, OPV3, OPV4, and OPV5, that differ in conjugation length have been synthesized and fully characterized. All three compounds contain chiral side chains, long aliphatic chains, and a ureido-s-triazine hydrogen bonding unit. (1)H NMR and photophysical measurements show that the OPV oligomers grow hierarchically in an apolar solvent; initially, dimers are formed by hydrogen bonds that subsequently develop into stacks by pi-pi interactions of the phenylenevinylene backbone with induced helicity via the chiral side chains. SANS measurements show that rigid cylindrical objects are formed. Stacks of OPV4 have a persistence length of 150 nm and a diameter of 6 nm. OPV3 shows rigid columnar domains of 60 nm with a diameter of 5 nm. Temperature and concentration variable measurements show that the stability of the stacks increases with the conjugation length as a result of more favorable pi-pi interactions. The transfer of the single cylinders from solution to a solid support as isolated objects is only possible when specific concentrations and specific solid supports are used as investigated by AFM. At higher concentrations, an intertwined network is formed, while, at low concentration, ill-defined globular objects are observed. Only in the case of inert substrates (graphite and silicium oxide) single fibers are visible. In the case of the repulsive surfaces (mica and glass), clustering of the stacks occurs, while, at attractive surfaces (gold), the stacks are destroyed.