gebhart/patrepeval huggingface dataset:
Phase I clinical trial of oral rigosertib in patients with myelodysplastic syndromes (2013)

The multi-kinase inhibitor rigosertib (ON 01910.Na) induces mitotic arrest and apoptosis in myeloblasts, while sparing normal cells. The purpose of this study was to determine the pharmacokinetic profile, maximum-tolerated dose (MTD), safety, and clinical activity of an oral formulation of rigosertib in patients with myelodysplastic syndromes (MDS). For pharmacokinetic studies, patients received rigosertib in single escalating weekly doses. To determine the MTD, patient cohorts received escalating doses of rigosertib twice daily for 14 d of a 21-d cycle. Overall, 37 patients were treated. Rigosertib exposure increased with escalating oral doses. Mean absolute oral bioavailability ranged from 13·9% (fed) to 34·8% (fasting) in 12 patients treated at the 560 mg b.i.d. dose level. Dose-limiting toxicity (grade 3 dysuria and shortness of breath) occurred at the 700 mg b.i.d. dose. Five patients experienced grade 3 non-haematological toxicity, including symptoms of urothelial inflammation, hypotension and syncope, fatigue and abdominal pain. Encouraging signs of clinical activity included two bone marrow complete remissions in refractory anaemia with excess blasts type 1 patients previously treated with azacitidine. In addition, four patients each achieved transfusion independence and haematological improvements. In conclusion, oral rigosertib is bioavailable and well tolerated, and has clinical activity in patients with MDS.
Detonation Failure Thickness Measurement in an Annular Geometry (2007)

The failure thickness of neat nitromethane in aluminum confinement was measured using a novel experimental technique. The thickness was approximated in an annular geometry by the gap between a concentric aluminum tube and rod. This technique was motivated by the desire to have a periodic boundary condition in the direction orthogonal to the annulus thickness, rather than a free surface occurring in typical rectangular geometry experiments. This results in a two‐dimensional charge analogous to previous failure thickness setups but with infinite effective width (i.e. infinite aspect ratio). Detonation propagation or failure was determined by the observation of failure patterns engraved on the aluminum rod by the passing detonation. Analysis of these engraved patterns provides a statistical measurement of the spatial density of failure waves. Failure was observed as far as 180 thicknesses downstream. The failure thickness was measured to be 1.45 mm±0.15 mm.
Surgery for a chronic cystic hematoma on the right thigh in a hemophiliac A with a potent factor VIII inhibitor. (1982)

A surgical case is described of a 40-year-old hemophilia A patient with a potent factor VIII inhibitor (40 Bethesda units) suffering from a chronic cystic haematoma in the right thigh. Surgery was performed after extensive plasmapheresis and administration of a large amount of factor VIII concentrate (42,500 U on the day of operation). During the five post-operative days, the factor VIII level was maintained above 25%, which allowed control of hemorrhage. However, two serious problems, i.e., hemolytic anemia and anamnestic response of factor VIII inhibitor titer, occurred on the 6th post-operative day. The hemolytic anemia was circumvented by administering prothrombin complex concentrate every 8 hours for 12 days until the sutures were removed. There was no bleeding although the inhibitor titer rose to 460 Bethesda units.
CombiChem at Bayer CropScience: What We Have Learned, Exemplified by Recent Chemistries (2004)

At Bayer CropScience combinatorial chemistry has been used to significantly increase and diversify the compound collection for high throughput in vitro and in vivo screening. Quality aspects were seen critical along this process, from the selection of novel chemotypes with a known biological background to the purity of the test compounds. This will be exemplified by a benzotriazole library obtained by a polymer-bound version of the Sanger reagent attached via a traceless triazene linker (T1). After identification of initial fungicidal activity a thorough analysis in all relevant internal chemical and biological databases revealed the structural requirements for 2nd validation libraries, increasing the success likelihood to find potential leads worth further optimization. In a second combinatorial approach peptides with an agro-relevant mode of action will be used to derive new active ingredients. Based on cyclopropylideneacetate chemistry, a structurally extremely flexible peptidomimetic system has been developed for systematic modification of biologically important peptide motifs in potentially optimized conformations. The next step will be the identification of analogues based on this structural informations.
A Spectral Visualization System for Analyzing Financial Time Series Data (2006)

Visual data analysis of time related data sets has attracted much research interest recently, and a number of sophisticated visualization methods have been proposed in the past. In financial analysis, however, the most important and most common visualization techniques for time series data is the traditional line- or bar chart. Although these are intuitive and make it easy to spot the effect of key events on a assets price, and its return over a given period of time, price charts do not allow the easy perception of relative movements in terms of growth rates, which is the key feature of any price-related time series. This paper presents a novel Growth Matrix visualization technique for analyzing assets. It extends the ability of existing chart techniques by not only visualizing asset return rates over fixed time frames, but over the full spectrum of all subintervals present in a given time frame, in a single view. At the same time, the technique allows a comparison of subinterval return rates among groups of even a few hundreds of assets. This provides a powerful way for analyzing financial data, since it allows the identification of strong and weak periods of assets as compared to global market characteristics, and thus allows a more encompassing visual classification into "good" and "poor" performers than existing chart techniques. We illustrate the technique by real-world examples showing the abilities of the new approach, and its high relevance for financial analysis tasks.
Amorphous Tin Oxide Applied to Solution Processed Thin-Film Transistors (2019)

The limited choice of materials for large area electronics limits the expansion of applications. Polycrystalline silicon (poly-Si) and indium gallium zinc oxide (IGZO) lead to thin-film transistors (TFTs) with high field-effect mobilities (>10 cm<sup>2</sup>/Vs) and high current ON/OFF ratios (I<sub>On</sub>/I<sub>Off</sub> > ~10<sup>7</sup>). But they both require vacuum processing that needs high investments and maintenance costs. Also, IGZO is prone to the scarcity and price of Ga and In. Other oxide semiconductors require the use of at least two cations (commonly chosen among Ga, Sn, Zn, and In) in order to obtain the amorphous phase. To solve these problems, we demonstrated an amorphous oxide material made using one earth-abundant metal: amorphous tin oxide (a-SnO<sub>x</sub>). Through XPS, AFM, optical analysis, and Hall effect, we determined that a-SnO<sub>x</sub> is a transparent n-type oxide semiconductor, where the SnO<sub>2</sub> phase is predominant over the SnO phase. Used as the active material in TFTs having a bottom-gate, top-contact structure, a high field-effect mobility of ~100 cm<sup>2</sup>/Vs and an I<sub>On</sub>/I<sub>Off</sub> ratio of ~10<sup>8</sup> were achieved. The stability under 1 h of negative positive gate bias stress revealed a Vth shift smaller than 1 V.
IR and thermal estimation tools, with applications to the GUTS 1 GHz processor (1998)

Estimation for thermal effects and voltage decay across power grids in very high operating frequencies has become a crucial step in deep submicron designs. The power consumption of each circuit macro must be factored in the power grid synthesis so as to minimize potentially dangerous thermal hazards. The estimation of the voltage variation in the Vdd and ground lines across different layers of the chip's power grid guarantees the early detection of low operational voltages spots that may cause circuit malfunction. This paper presents an efficient technique to analyze the thermal and supply voltage state across the floorplan in an early stage of the design cycle. This technique is a 1st order analysis based on an intent-based extraction of the power grid. This is especially useful since the power grid is specified by basic geometric parameters, which can be changed to optimize the operational voltage range.
Amputee socks (2015)

The mean difference in thickness between 3-ply and 5-ply used socks was equal to the standard deviation of each ply group (0.3mm). Therefore, it is possible that a 3-ply sock worn for as a little as 1 month could have a greater thickness than a 5-ply sock worn for a month.
On the EVM computation of arbitrary clipped multi-carrier signals (2011)

A common figure of merit in multi-carrier systems is the error vector magnitude (EVM). A method for EVM computation of a multi-carrier signal without any underlying model (e.g., the Gaussianity assumption) was proposed in a previous work of the authors. However, it addressed only the case of identical constellations and power loadings in all tones. In practice, however, the constellation and power loading may vary among the tones (e.g., boosted pilots, waterfilling and zero guard bands). Here the earlier approach is generalized in such a way that it is able to accommodate for an accurate analytical EVM computation in the cases of power loading and different constellations for different tones. Moreover, the derivation is valid for a general magnitude clipping function, so that any realistic clipper can be plugged in.
Time‐lapse seismic and the rough‐sea wavelet (2000)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 2000Time‐lapse seismic and the rough‐sea waveletAuthors: Robert LawsEd KraghRobert LawsSchlumberger and Ed KraghSchlumbergerhttps://doi.org/10.1190/1.1815720 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1815720FiguresReferencesRelatedDetailsCited ByImproving the interpretability of air-gun seismic reflection data using deterministic filters: A case history from offshore Cape Leeuwin, southwest AustraliaGEOPHYSICS, Vol. 76, No. 3Bibliography6. The Road Ahead21 March 2010The effect of noise generated by previous shots on seismic reflection dataGEOPHYSICS, Vol. 73, No. 3References21 March 2012Rough‐sea deghosting using a single streamer and a pressure gradient approximationGEOPHYSICS, Vol. 67, No. 6 SEG Technical Program Expanded Abstracts 2000ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 2000 Pages: 2484 publication data© 2000 Copyright © 2000 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 04 Jan 2005 CITATION INFORMATION Robert Laws and Ed Kragh, (2000), "Time‐lapse seismic and the rough‐sea wavelet," SEG Technical Program Expanded Abstracts : 1603-1606. https://doi.org/10.1190/1.1815720 Plain-Language Summary PDF DownloadLoading ...
Multicolor silicon-quantum-dot light-emitting diodes (2013)

Size-separated and colloidally stable silicon nanoparticles provide a novel non-toxic light-emitting material for efficient, stable and color-tunable electroluminescence.
<title>Registration method providing high visual magnification of microposition errors</title> (1997)

An image registration method is proposed which provides high visual magnification of micro-position errors so that they may be easily quantified with an unaided eye. The method consists of overprinting a pair of fine line or screen patterns of the same spatial frequency in which one pattern functions as a variable mask that unveils a stepped image embedded in the second pattern in proportion to registration error. The larger scale image can be composed of one or a series of symbols each designed to be unmasked at specific registration error thresholds. Pattern structure and duty cycle differences are used to create the masking function. The use of embedded images allows for a wide variety of visual symbols to be displayed at precise error thresholds. The large symbol dimensions provide the high visual magnification, typically a factor of 100 to 100. Advantages over moire technique are that the symbol outline is sharp, its shape is not dependent on interference effects, and it can independently designed to optimize for intuitive visual impact. Applications include a visual pass/fail mark, a numerical scale providing coarse error measurement, and the printed equivalent of a quadrature detector indicating direction and magnitude of error. The position sensing image pair is compact and suitable for photographic, offset printing or other image generation/replication processes where registration is critical. Imagesetter results for a 0.3 mil registration threshold sensor will be presented.
Reaction Parameter Effects on Metal-Salt-Catalyzed Aqueous Biphasic Pulping Systems (2002)

Metal salts (MgSO4 and Li2SO4) that serve to catalyze wood delignification and also contribute to the formation of aqueous biphasic systems (ABSs) have been studied. The influence of treatment conditions on the pulp properties (measured as the kappa number, residual pulp yield) has been determined by means of a 24 factorial design. The effects of the variables (temperature, time, salt, and polymer concentration) have been determined. Wood and pulp samples and lignin resulting from this process have been characterized by scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectroscopy.
Modeling reversible self-discharge in series-connected Li-ion battery cells (2013)

Large battery systems like those in plug-in hybrid or pure electric vehicles contain strings of series-connected cells. Cell voltage imbalances within strings decrease useful string capacity and increase cell ageing. Balancing systems are often employed to alleviate imbalances but optimal design and sizing requires prediction of expected imbalance. This paper presents a methodology for simulating voltage imbalances caused by temperature-dependent reversible self-discharge processes in cells. Simulation results for a three-cell string with a 4°C operating cell temperature difference over 30 days show a maximum cell voltage divergence of less than 1mV. The same simulation with a malfunction-typical operating temperature difference of 20°C leads to a maximum voltage divergence of over 5mV. The results and underlying methodology are of value for battery pack manufacturers and designers of balancing systems.
Thermal Load in Sliders for Hybrid Recording (2004)

We review the fundamental issue standing in the path of continued improvement in areal density in magnetic hard disk drives, namely, the superparagmagnetic effect. We also describe some of the optical components of a hybrid or heat assisted magnetic recording system, which is one possible solution to this technical challenge. We note the potential for heat assisted magnetic recording to achieve increased information storage densities at reasonable signal to noise ratios. Finally we identify an issue exacerbated by the introduction of thermal assistance of magnetic recording, namely that of the additional thermal load on the slider. We describe an experimental apparatus that we have employed to quantify the temperature rise in a slider when it is subjected to particular thermal loads at various locations on the slider body.
P‐50: 42‐inch PDP Autostereoscopic 3D Display (2003)

Abstract We have made a 42‐inch PDP autostereoscopic three‐dimensional display. A sheet of lenticular lens is placed in front of a 42‐inch PDP of full color XGA. The surface temperature of a PDP can be high during its operating times. The pitch of lenticular lens may be expanded. It makes an undesirable problem of deteriorating the 3D image quality. To overcome this problem, we have developed a 3D simulator to design a lenticular lens properly and measured the thermal expansion ratio of the lenticular lens and the surface temperature of the PDP. These two measured values have been used in the design of lenticular lens.
A molecular view of the role of chirality in charge-driven polypeptide complexation (2014)

Polyelectrolyte molecules of opposite charge are known to form stable complexes in solution. Depending on the system conditions, such complexes can be solid or liquid. The latter are known as complex coacervates, and they appear as a second liquid phase in equilibrium with a polymer-dilute aqueous phase. This work considers the complexation between poly(glutamic acid) and poly(lysine), which is of particular interest because it enables examination of the role of chirality in ionic complexation, without changes to the overall chemical composition. Systematic atomic-level simulations are carried out for chains of poly(glutamic acid) and poly(lysine) with varying combinations of chirality along the backbone. Achiral chains form unstructured complexes. In contrast, homochiral chains lead to formation of stable β-sheets between molecules of opposite charge, and experiments indicate that β-sheet formation is correlated with the formation of solid precipitates. Changes in chirality along the peptide backbone are found to cause "kinks" in the β-sheets. These are energetically unfavorable and result in irregular structures that are more difficult to pack together. Taken together, these results provide new insights that may be of use for the development of simple yet strong bioinspired materials consisting of β-rich domains and amorphous regions.
Model Reference Adaptive Control (2023)

This paper first goes into the basic issues of Model Reference Adaptive Control (MRAC) design and gives some theoretical results regarding continuous-time MRAC and the extension with discrete-time parameter estimation schemes. Next, a specific case is considered in which all plant state variables are accessible. This forms a basis for the extension to MRAC with only output feedback. In the following, robustness of MRAC with respect to external and state-dependent disturbances is treated and finally the relation of MRAC with other methods is touched upon
Hertz Contact Based Scaling of Puncture Forces for Large Scale Needle Prototypes Using a Gelatinous Tissue Phantom (2010)

In order to test small scale medical devices, it is often necessary to prototype them on a larger scale such that proof-of-concept tests can be made more affordably and design details can be tested more easily. This article discusses a method of scaling large needle prototypes for testing in a gelatin phantom such that puncture forces match those expected for the actual-size needle when puncturing tissue. Using Hertz contact force equations to account for the differences in prototype materials and size, as well as for the tissue phantom properties, 10× scale prototype needles were inserted into a gelatin phantom and puncture forces were compared with those of a real scale prototype in bovine liver tissue. Results showed that for a 19 gauge (1.06 mm) stainless steel needle tip, where a maximum doctor-applied load of 5 N was desired to pierce liver tissue, loads of 0.44 N using Hertz point contact, and 0.31 N using Hertz line contact methods were predicted to puncture liver tissue, and an average load of 0.31 N was observed in force-displacement measurements. With a 10× scale stereolithographed needle prototype, Hertz point contact predicted a load of 0.31 N to puncture a gelatin phantom, Hertz line contact theory predicted 0.37 N, and an average load of 0.73 N observed in force displacement measurements. Similar contact mechanics based scaling methods might be applied to cutting devices.
Supplemental Tables 1 and 2 from BET Bromodomain Inhibitors Enhance Efficacy and Disrupt Resistance to AR Antagonists in the Treatment of Prostate Cancer (2023)

&lt;p&gt;Antibodies and PCR Primers&lt;/p&gt;
Infrared absorption spectra of vinyl radicals isolated in solid Ne (2008)

Irradiation of samples of solid Ne near 3.0 K containing ethene (C(2)H(4)) with vacuum ultraviolet radiation at 120 nm from synchrotron yielded new spectral lines at 3141.0, 2953.6, 2911.5, 1357.4, 677.1, 895.3, and 857.0 cm(-1). These features are assigned to alpha-CH stretching (nu(1)), CH(2) antisymmetric stretching (nu(2)), CH(2) symmetric stretching (nu(3)), CH(2)-bending (nu(5)), HCCH cis bending (nu(7)), CH(2) out-of-plane bending (nu(8)), and alpha-CH out-of-plane bending (nu(9)) modes of C(2)H(3), respectively, based on results of (13)C- and D-isotopic experiments and quantum-chemical calculations. These calculations using density-functional theory (B3LYP and PW91PW91/aug-cc-pVTZ) predict vibrational wavenumbers, IR intensities, and isotopic ratios of vinyl radical that agree satisfactorily with our experimental results.
Fiber-optic transmission and networking: the previous 20 and the next 20 years [Invited] (2018)

Celebrating the 20<sup>th</sup> anniversary of Optics Express, this paper reviews the evolution of optical fiber communication systems, and through a look at the previous 20 years attempts to extrapolate fiber-optic technology needs and potential solution paths over the coming 20 years. Well aware that 20-year extrapolations are inherently associated with great uncertainties, we still hope that taking a significantly longer-term view than most texts in this field will provide the reader with a broader perspective and will encourage the much needed out-of-the-box thinking to solve the very significant technology scaling problems ahead of us. Focusing on the optical transport and switching layer, we cover aspects of large-scale spatial multiplexing, massive opto-electronic arrays and holistic optics-electronics-DSP integration, as well as optical node architectures for switching and multiplexing of spatial and spectral superchannels.
Inhibition of the Detrimental Effects of Water Impurities in Lithium-Ion Batteries (2007)

The effect of dimethyl acetamide (DMAc) on the stability of LiP F6 based electrolytes contaminated with water impurities has been investigated. Addition of 1% DMAc to 1 M LiP F6 in 1:1:1 ethylene carbonate/diethyl carbonate/dimethyl carbonate (EC/DEC/DMC) with 0.5% water impurity was found to inhibit the generation of HF and other decomposition products. The presence of water results in a decrease in the first cycle efficiency and an increase in the capacity fade in following cycles. The addition of DMAc to water containing electrolytes has little effect on the first cycle efficiency, but it reduces the capacity fade of the batteries containing water impurities by 72%. © 2007 The Electrochemical Society.