gebhart/patrepeval huggingface dataset:
Enabling automated integration testing of cloud application services in virtualized environments (2011)

Software development under the cloud comput-ing model brings the advantage that new ap-plications can be rapidly constructed by tai-loring existing services. However, the use of Internet-based services as software compo-nents, leads to the development of applications in which some building blocks are hosted re-motely, rather than locally in a controlled en-vironment. This aspect of cloud-based develop-ment, when coupled with factors such as service autonomy, complexity, and high dependability criteria, make software testing of the cloud es-pecially challenging. In this paper we present a novel approach to support integration testing of applications that depend on remotely-hosted cloud services. Our approach seeks to reuse elements of the test au-tomation, typically built to validate a cloud ser-vice prior to its deployment, for the realization of Test Support-as-a-Service (TSaaS). TSaaS provides developers with a set of functions that enable integration testing of cloud services us-ing controlled virtual environments. To facili-tate continued evaluation of our approach, we have implemented a prototype of TSaaS that is compatible with the Windows Azure platform. Copyright c © 2011 Tariq M. King, Annaji S. Ganti, and David Froslie. Permission to copy is hereby granted provided the original copyright notice is reproduced in copies made. 1
An Electric Vehicle Charge Scheduling Approach Suited to Local and Supplying Distribution Transformers (2020)

Distribution networks with high electric vehicle (EV) penetration levels can experience transformer overloading and voltage instability issues. A charge scheduling approach is proposed to mitigate against these issues that suits smart home settings in residential areas. It comprises measurement systems located at distribution transformers that communicate directly with fuzzy logic controller (FLC) systems embedded within EV supply equipment (EVSE). This realizes a reduction in data processing requirements compared to more centralized control approaches, which is advantageous for distribution networks with large numbers of transformers and EV scheduling requests. A case study employing the proposed approach is presented. Realistic driver behavior patterns, EV types, and multivariate probabilistic modeling were used to estimate EV charging demands, daily travel mileage, and plug-in times. A Monte Carlo simulation approach was developed to obtain EV charging loads. The effectiveness of mitigation in terms of reducing distribution transformer peak load levels and losses, as well as improving voltage stability is demonstrated for a distribution network in Jakarta, Indonesia.
Genetically engineeredE. coliNissle attenuates hyperammonemia and prevents memory impairment in bile‐duct ligated rats (2021)

S-ARG and S-ARG + BUT attenuated hyperammonemia, with S-ARG + BUT additional memory protection likely due to greater anti-inflammatory effect. These innovative strategies, particularly S-ARG + BUT, have potential to prevent HE.
Dopant selection for control of charge carrier density and mobility in amorphous indium oxide thin-film transistors: Comparison between Si- and W-dopants (2015)

The dependence of oxygen vacancy suppression on dopant species in amorphous indium oxide (a-InOx) thin film transistors (TFTs) is reported. In a-InOx TFTs incorporating equivalent atom densities of Si- and W-dopants, absorption of oxygen in the host a-InOx matrix was found to depend on difference of Gibbs free energy of the dopants for oxidation. For fully oxidized films, the extracted channel conductivity was higher in the a-InOx TFTs containing dopants of small ionic radius. This can be explained by a reduction in the ionic scattering cross sectional area caused by charge screening effects.
Efficient Dynamic Nuclear Polarization at 800 MHz/527 GHz with Trityl‐Nitroxide Biradicals (2015)

Abstract Cross‐effect (CE) dynamic nuclear polarization (DNP) is a rapidly developing technique that enhances the signal intensities in magic‐angle spinning (MAS) NMR spectra. We report CE DNP experiments at 211, 600, and 800 MHz using a new series of biradical polarizing agents referred to as TEMTriPols, in which a nitroxide (TEMPO) and a trityl radical are chemically tethered. The TEMTriPol molecule with the optimal performance yields a record 1 H NMR signal enhancement of 65 at 800 MHz at a concentration of 10 m M in a glycerol/water solvent matrix. The CE DNP enhancement for the TEMTriPol biradicals does not decrease as the magnetic field is increased in the manner usually observed for bis‐nitroxides. Instead, the relatively strong exchange interaction between the trityl and nitroxide moieties determines the magnetic field at which the optimum enhancement is observed.
Observing secondary-electron yield and charging in an insulating material by ultralow-voltage scanning electron microscope (2021)

Secondary-electron yield (SEY) and surface charging of various insulating materials under irradiation of primary electrons (PEs) with energy of lower than 100 eV were investigated. Irradiation energy of the PEs with SEY of 1 (E1) for SiO2 and Si3N4 was about 20 eV and that for the resist using in extreme ultraviolet (EUV) lithography was about 40 eV. Additionally, it was found that E1 corresponds to the lower limit for obtaining scanning electron microscope images of the EUV resist pattern. The surface potential of the pattered EUV resist modulated by PE irradiation was estimated by using a retarding-field energy filter. It was found that the surface potential varies with the width and pitch of the EUV resist pattern. The variation of surface potential depends on the width and pitch due to the fact that the secondary electrons emitted from the space of the resist pattern are absorbed in the sidewalls of the resist pattern as it becomes denser.
Intentional internal iliac artery occlusion in endovascular repair of abdominal aortic aneurysms. (2002)

Endoluminal grafting of aortoiliac aneurysms is an evolving technology. Since many lesions involve part of all of the common iliac arteries, it may be necessary to cover the internal iliac (hypogastric) arteries. Since the internal iliac arteries are important for flow to pelvic organs and perhaps the colon, their sacrifice may not be innocuous, especially since reimplantation of the inferior mesenteric artery is not possible during endovascular aneurysm repair. Most series reflect the relative safety of unilateral internal iliac artery sacrifice. Bilateral hypogastric artery sacrifice, especially if not staged temporally, may cause more significant complications. The incidence of claudication and impotence remains significant, prompting some to recommend revascularization of at least one internal iliac artery at the time of aneurysm repair in order to preserve one of these important vessels. Such an internal iliac artery bypass can be simply performed during endovascular aneurysm repair. The development of larger, more precisely deployed iliac limbs as well as the development of branched devices should decrease the need for internal iliac artery sacrifice.
Cardiovascular magnetic resonance imaging of functional and microstructural changes of the heart in a longitudinal pig model of acute to chronic myocardial infarction (2021)

During chronic follow-up after myocardial infarction, cardiac diffusion tensor imaging provides a higher sensitivity for mapping microstructural alterations when compared to non-contrast enhanced relaxometry with the added benefit of providing directional tensor information to assess remodelling of myocyte aggregate orientations, which cannot be otherwise assessed.
Patterns of apparent co-operativity in a simple random non-equilibrium enzyme–substrate–modifier mechanism. Comparison with equilibrium allosteric models (1979)

It has often been claimed that random non-equilibrium mechanisms can result in apparent homotropic and heterotropic effects in steady-state kinetics of the kind more usually attributed to intersubunit allosteric interactions. However, it has never been shown whether any simple random mechanism could in fact give patterns of apparent interaction similar to those predicted by the well-known allosteric models. The patterns of apparent substrate co-operativity and affinity given by the steady-state of a standard simple random substrate-modifier mechanism in which catalytic velocity is proportional to substrate binding have been analysed mathematically and numerically. All patterns possible with this model are described. Some of them rather resemble those possible with standard allosteric models, in that there is a high-affinity and a low-affinity form at zero and infinite modifier concentrations (or vice versa) which show Michaelian behaviour, apparent co-operativity passing through a maximum or minimum at intermediate affinities. Unlike the allosteric models the family of curves is in principle not symmetrical. The random model can also give behaviour not possible with the standard allosteric models, such as higher substrate affinity at intermediate modifier concentrations than at either zero or infinite modifier, with concomitant negative apparent substrate co-operativity, or a single change of sign of apparent substrate co-operativity. The analysis uses recently discovered simplified forms of steady-state equations for random models.
Design of monolithic silicon photonics at 25 Gb/s (2017)

Monolithic CMOS photonics seeks to minimize total transceiver cost by simplifying packaging, design and test. Here, I examine 25 Gb/s applications in commercially available process technology with a focus on receiver sub-system optimization.
Developmient ofSingle PaseUP having ACChper andA.,cti've Filter Ab1iity (2006)

jp Abstract- Thispaperdescribes aboutdevelopment ofsinglevarious typeUPSforthepurpose ofrealizing highefficiency, phase uninterruptible powersupply (UPS)having AC choppermaintenance free, longlife, small size ofthesystem(l)-(6). andactive filter ability. Theproposed UPSconsists ofasingle Thispaperproposes themaincircuit andcontrol method phase full bridge type active filter andthesource andloadside AC ofthesingle phaseUPShaving AC chopper andactive filter choppers using bidirectional IGBTswitches. Itrealizes long lifeability. ThisAC choppers oftheproposed UPSareassembled andmaintenance free ofthemaincircuit because ithasnouseof byusing thebidirectional IGBTswitches whichconsists ofthe thebulky electrolytic capacitor. Theproposed UPShasactive filter twounidirectional IGBTswitches. Thecircuit configuration ability between thesource andloadside choppers, whichrealizes doesnotrequire thebulkyelectrolytic capacitor. TheAC unity input powerfactor operation. TheACchopper regulates the choppers carry outtostable output voltage control, andthefull output voltage sinusoidaly. Thefundamental sourcepowersuPPlY bridge type active filter hasunity input powerfactor ability and totheloadindirect without switching oftheevery AC choppersenergy charge/discharge ability ofthebattery. Underthenormal underthenormalpowercondition, whichachieves high efficient powercondition, thesourcepowersupply totheloadwithhigh system andhigh system reliability, aneac ok fUS.Teeoe B Battery B.C. .Batt ryCongtroller, Cd:. Bolkyel trolytie capacitor many~~~~~~~~~~~ reerhr hav bee prpoe an netiae h Fig. 1L. MLain circuit configuration ofthcconvcntional UPShavingactivc filtcr ability.
ChemInform Abstract: Antinflammatory Agents. Part 10. 1‐(4‐Chlorophenyl)‐2‐pyrazolin‐5‐one Derivatives. (1987)

Abstract The pyrazolinone (I) is refluxed with s‐triazine (II) to yield the derivative (III).
Synthesis of Quadband mm-Wave Microstrip Antenna Using Genetic Algorithm for Wireless Application (2023)

Antennas with multifunctional capabilities integrated into a single device that demonstrates a high performance are in demand, and microstrip antennas with quadband coverage are very useful for a wide range of mm-wave applications. Antennas and propagation at mm-wave frequencies, on the other hand, poses several challenges which can be overcome by applying performance enhancement techniques to meet design objectives. This article presents the use of a binary-coded genetic algorithm for developing an improved quadband mm-wave microstrip patch antenna. The patch shape was optimized by dividing a conducting surface into 6 × 6 tiny rectangular blocks. The algorithm generated the solution space by introducing conducting and nonconducting features for each radiating cell on the patch surface and then greedily searched for the best-fitted individual based on the cost function. With the combination of High-Frequency Structure Simulator (HFSS) and MATLAB, candidate antennas were iteratively modeled by applying the suggested algorithm. The optimized antenna resonated at four frequencies centered at 28.3 GHz, 38.1 GHz, 46.6 GHz, and 60.0 GHz. The antenna realized a peak broadside directivity of 7.8 dB, 8.8 dB, 7.3 dB, and 7.1 dB, respectively, with a total operating bandwidth of 11.5 GHz. The research findings were compared with related works presented in the literature and found that the optimized antenna outperformed them in terms of bandwidth, directivity, and efficiency.
Superconducting Quantum Arrays for broadband RF systems (2013)

Superconductive Quantum Arrays (SQA) are suggested for the implementation of broadband radio frequency systems capable of providing highly linear magnetic signal to voltage transfer with high dynamic range. Possible basic cells of the arrays and their attainable characteristics are considered. Results of experimental studies and possible applications are presented and discussed.
tmle: AnRPackage for Targeted Maximum Likelihood Estimation (2012)

Targeted maximum likelihood estimation (TMLE) is a general approach for constructing an efficient double-robust semi-parametric substitution estimator of a causal effect parameter or statistical association measure. tmle is a recently developed R package that implements TMLE of the effect of a binary treatment at a single point in time on an outcome of interest, controlling for user supplied covariates, including an additive treatment effect, relative risk, odds ratio, and the controlled direct effect of a binary treatment controlling for a binary intermediate variable on the pathway from treatment to the out- come. Estimation of the parameters of a marginal structural model is also available. The package allows outcome data with missingness, and experimental units that contribute repeated records of the point-treatment data structure, thereby allowing the analysis of longitudinal data structures. Relevant factors of the likelihood may be modeled or fit data-adaptively according to user specifications, or passed in from an external estimation procedure. Effect estimates, variances, p values, and 95% confidence intervals are provided by the software.
polymake in Linear and Integer Programming (2014)

In integer and linear optimization the software workhorses are solvers for linear programs (based on simplex or interior point methods) as well as generic frameworks for branch-and-bound or branch-and-cut schemes. Comprehensive implementations are available both as Open Source, like SCIP [2], as well as commercial software, like CPLEX [21] and Gurobi
Fractal Inorganic−Organic Interfaces in Hybrid Membranes for Efficient Proton Transport (2013)

Abstract A facile method for preparing highly conductive hybrid organic−inorganic membranes is reported. These membranes are synthesized using an electrospinning process with a sol−gel‐based solution containing PVDF−HFP (polyvinylidenefluoride‐hexafluoropropylene), functionalized or not functionalized silicon alkoxides, and additives. Proton conduction measurements highlight that these hybrid membranes exhibit conductivity value of 101 mS/cm at 120 °C under 80% RH (relative humidity), comparable to the best Nafion measured under the same conditions. These membranes have a proton conductivity‐humidity variation close to Nafion and a modulus value higher than that for Nafion above 80 °C. Their proton conductivity value is about 15 mS/cm under 50% RH, and it constitutes one of the highest values reported. These interesting properties are related to the microstructure of the electrospun membranes that have been characterized using field emission scanning electron microscopy (FE‐SEM) and small angle neutron scattering (SANS). The electrospun membranes are made composed of a bundle of fibers surrounded by a functionalized silica network. The bundle of fibers corresponds to the assembly of small polymer fibers surrounded by small anisotropic functionalized silica domains. Coupling the reactive chemistry of the sol–gel‐based process with electrospinning allows the design of hybrid membranes with fractal hydrophobic/hydrophilic interfaces exhibiting different length scales.
Transmission in optically transparent core networks: introduction to the feature issue (2008)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Rich Jensen, Miroslav Karasek, Daniel C. Kilper, and Klaus Petermann, "Transmission in optically transparent core networks: introduction to the feature issue," J. Opt. Netw. 7, 215-216 (2008) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
The Truncated Isoform of Somatostatin Receptor5 (sst5TMD4) Is Associated with Poorly Differentiated Thyroid Cancer (2014)

Somatostatin receptors (ssts) are expressed in thyroid cancer cells, but their biological significance is not well understood. The aim of this study was to assess ssts in well differentiated (WDTC) and poorly differentiated thyroid cancer (PDTC) by means of imaging and molecular tools and its relationship with the efficacy of somatostatin analog treatment. Thirty-nine cases of thyroid carcinoma were evaluated (20 PDTC and 19 WDTC). Depreotide scintigraphy and mRNA levels of sst-subtypes, including the truncated variant sst5TMD4, were carried out. Depreotide scans were positive in the recurrent tumor in the neck in 6 of 11 (54%) PDTC, and in those with lung metastases in 5/11 cases (45.4%); sst5TMD4 was present in 18/20 (90%) of PDTC, being the most densely expressed sst-subtype, with a 20-fold increase in relation to sst2. In WDTC, sst2 was the most represented, while sst5TMD4 was not found; sst2 was significantly increased in PDTC in comparison to WDTC. Five depreotide positive PDTC received octreotide for 3-6 months in a pilot study with no changes in the size of the lesions in 3 of them, and a significant increase in the pulmonary and cervical lesions in the other 2. All PDTC patients treated with octreotide showed high expression of sst5TMD4. ROC curve analysis demonstrated that only sst5TMD4 discriminates between PDTC and WDTC. We conclude that sst5TMD4 is overexpressed in PDTC and may be involved in the lack of response to somatostatin analogue treatment.
TFIIH moonlighting at telomeres. (2022)

Although telomeres are essential for chromosome stability, they represent fragile structures in our genome. Telomere shortening occurs during aging in cells lacking telomerase due to the end replication problem. In addition, recent work uncovered that the bulk of telomeric DNA poses severe hurdles for the semiconservative DNA replication machinery, requiring the assistance of an increasing number of specialized factors that prevent accidental telomere loss or damage events. In this issue of <i>Genes & Development</i>, Yang and colleagues (pp. 956-969) discover that TFIIH, a basic component of the PolII transcription initiation and nucleotide excision repair machinery, facilitates telomere replication. TFIIH is recruited to telomeres by the shelterin component TRF1, taking on at telomeres a moonlighting function.
Abstract 2966: Novel ex vivo model for ERα positive breast cancer (2021)

Abstract Three-dimensional ex vivo cultures from patient-derived tumor tissue offer new opportunities for drug development and personalized treatment of cancer. However, one of the main challenges in establishing a tumor type faithful ex vivo tissue culture system is in optimization of biochemical and physical microenvironment to preserve desired phenotypic features. A collaboration with the Helsinki University Hospital enables us to receive live patient-derived breast cancer tissue samples from most breast cancer surgeries performed in the Southern Finland, typically samples arriving twice a week. Together with a group of materials scientists from Aalto Technical University we have explored seven different 3D culture matrices and defined their biomechanical properties and stiffness values with rheological measurements. Four investigated matrices preserved the luminal CK8+ cell phenotype of the luminal cancers they derived from, whereas rest of the matrices that included commonly used Matrigel and collagen scaffolds promoted a switch in the cell identity from luminal CK8+ to basal CK14+ phenotype. Furthermore, the genetic expression profiles examined with NGS corresponded to observed phenotypic switch. We noticed significant species-specific differences between mouse mammary and human breast samples in their morphology, phenotypic responses and ERα+ preservation to microenvironmental matrix stiffness. Furthermore, a combination of scaffold stiffness and composition of biochemical matrix constituency is required for long-term maintenance of ERα+ luminal tumour phenotype. Therefore, both physical properties and composition of the microenvironment need to be optimized for maintenance of breast tumor type specific phenotype and genetic profiles of ex vivo tumor explant cultures. Citation Format: Pauliina M. Munne, Lahja Martikainen, Iiris Räty, Kia Bertula, Nonappa Nonappa, Aino Peura, Minna Mutka, Marjut Leidenius, Tuomo Meretoja, Panu Kovanen, Johanna Mattson, Paivi Heikkila, Heikki Joensuu, Olli Ikkala, Juha T. Klefstrom. Novel ex vivo model for ERα positive breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr 2966.
CREBBP and STAT6 co-mutation and 16p13 and 1p36 loss define the t(14;18)-negative diffuse variant of follicular lymphoma (2020)

The diffuse variant of follicular lymphoma (dFL) is a rare variant of FL lacking t(14;18) that was first described in 2009. In this study, we use a comprehensive approach to define unifying pathologic and genetic features through gold-standard pathologic review, FISH, SNP-microarray, and next-generation sequencing of 16 cases of dFL. We found unique morphologic features, including interstitial sclerosis, microfollicle formation, and rounded nuclear cytology, confirmed absence of t(14;18) and recurrent deletion of 1p36, and showed a novel association with deletion/CN-LOH of 16p13 (inclusive of CREBBP, CIITA, and SOCS1). Mutational profiling demonstrated near-uniform mutations in CREBBP and STAT6, with clonal dominance of CREBBP, among other mutations typical of germinal-center B-cell lymphomas. Frequent CREBBP and CIITA codeletion/mutation suggested a mechanism for immune evasion, while subclonal STAT6 activating mutations with concurrent SOCS1 loss suggested a mechanism of BCL-xL/BCL2L1 upregulation in the absence of BCL2 rearrangements. A review of the literature showed significant enrichment for 16p13 and 1p36 loss/CN-LOH, STAT6 mutation, and CREBBP and STAT6 comutation in dFL, as compared with conventional FL. With this comprehensive approach, our study demonstrates confirmatory and novel genetic associations that can aid in the diagnosis and subclassification of this rare type of lymphoma.