gebhart/patrepeval huggingface dataset:
Development of an Advanced Autostereoscopic Display Employing Temporal Multiplexing (2007)

The development of an autostereoscopic display based upon temporally multiplexing is described. The advent of high framerate spatial light modulators, high performance graphical processing units and high bandwidth data buses render such a design viable.
Impacts of Zero Net Energy Buildings on Customer Energy Savings and Distribution System Planning (2019)

This paper presents a customer-oriented, data-driven distribution system planning method for quantifying impacts of Zero-Net-Energy (ZNE) buildings on customer energy savings and distribution system operation. A ZNE building refers to a building whose total amount of energy consumed is roughly equal to self-generated energy on an annual basis. By replacing old appliances with new energy efficient appliances, a retrofit building is called “ZNE ready”. By installing rooftop photovoltaics (PV) systems together with energy storage devices, a building can be converted to “ZNE”. Smart meter data collected from 5000 buildings at 30-minute resolution in 2016 are used as the baseline energy consumption. To create “ZNE ready” load profiles, water heater and air conditioning loads are first separated from the total building energy consumption so they can be replaced by energy efficient water heaters and air conditioner load profiles. To create “ZNE” load profiles, the size of the PV system is calculated and the PV outputs are subtracted from the “ZNE ready” load profile. By studying the power flow changes before and after ZNE technology is implemented, impacts of ZNE buildings on customer payments and on distribution system operation are quantified using the actual feeder topology and network data in Duke Energy North Carolina service areas.
Identification of the Helicobacter pylori VacA Toxin Domain Active in the Cell Cytosol (1998)

Cells exposed to Helicobacter pylori toxin VacA develop large vacuoles which originate from massive swelling of membranous compartments at late stages of the endocytic pathway. When expressed in the cytosol, VacA induces vacuolization as it does when added from outside. This and other evidence indicate that VacA is a toxin capable of entering the cell cytosol, where it displays its activity. In this study, we have used cytosolic expression to identify the portion of the toxin molecule responsible for the vacuolating activity. VacA mutants with deletions at the C and N termini were generated, and their activity was analyzed upon expression in HeLa cells. We found that the vacuolating activity of VacA resides in the amino-terminal region, the whole of which is required for its intracellular activity.
LATE BLOCKADE OF B7-1 COSTIMULATION INTERRUPTS THE DEVELOPMENT OF CHRONIC REJECTION IN A RAT MODEL OF CARDIAC TRANSPLANTATION. (1998)

720 We have previously shown that CTLA4Ig prevents the development of chronic allograft rejection in the Lew to F344 rat heterotopic cardiac transplant model (JCI, 1996; 97: 833). CTLA4Ig blocks both B7-1 and B7-2: two costimulatory molecules which are known to exhibit differing temporal expression and functional characteristics in vitro and in vivo. To dissect the individual role of B7-1 in the pathogenesis of chronic allograft rejection we used a mutant form of CTLA4Ig, Y100F, which blocks B7-1 but not B7-2. Early administration of Y100F, either as a single dose (0.5mg i.p.) (group A, n=5) or multiple doses (0.5mg i.p. 2x/wk) (group B, n=4) starting day 2 post transplantation failed to prolong graft survival as compared to untreated control (Group C, n=6; all animals rejected their grafts within 3 weeks). This is in sharp contrast to the effects of CTLA4Ig given at this time point which results in prolonged graft survival (> 100 days) in more than 60% of animals. We then studied the effects of late blockade of B7-1. Animals received 30 days of low dose CsA (1 mg1day s.c.) to prevent acute rejection followed by either Y100F (group D; n=8), or control fusion protein (group E, n=19) at 0.5mg 2x/wk for 4 wks starting 1 month post transplantation, or continuous CsA (1 mg1day s.c.) (group F, n=5). Both selective late blockade of B7-1 by Y100F (D) and continuous CsA treatment (F) significantly prolonged allograft survival but only Y100F treatment interupted development of graft arteriosclerosis, the sine qua non of chronic allograft rejection. Mean arteriosclerotic score in grafts surviving >100days was 0.91±0.5* in the Y100F group (D), compared to 1.76±1.53 in the continuous CsA treated group (F) and 1.72±0.53 in the control fusion protein group (E). Furthermore, histological analysis of graft specimens revealed significantly less graft fibrosis in the Y100F treated groups (D) compared to control (E) and continuous CsA (F) groups. Consistent with these findings, semi-quantitative PCR revealed significantly reduced tissue expression of TGF-β mRNA in grafts from the Y100F treated group. These data show that blocking B7-1 late but not early posttransplantation is effective at interrupting progression of chronic rejection. These findings are consistent with the later temporal expression of B7-1 during the alloimmune response. *p<0.05 compared to control group (D).Figure
Acid−Base Profiling of Imatinib (Gleevec) and Its Fragments (2004)

The site-specific basicities of imatinib (Gleevec, a new signal transduction inhibitor drug of chronic myeloid leukemia) and two of its fragment compounds were quantitated in terms of protonation macroconstants, microconstants, and group constants by NMR-pH and pH-potentiometric titrations. Sequential protonation of imatinib follows the N(34), N(11), N(31), N(13) order, in which N(11) and N(31) show commensurable basicity, but negligible intramolecular interaction. Fragment compounds include two "halves" of imatinib, and their moiety-specific basicities confirm the NMR-based protonation sequence of the parent compound. NMR-pH profiles, macro- and/or microscopic protonation schemes, and species-specific distribution diagrams are presented. On the basis of these data, imatinib is shown to be predominantly neutral, monocationic, and tricationic at intestinal, blood, and gastric pH, respectively. The molecular hypotheses on imatinib binding to the Bcr-Abl oncogene fusion protein are interpreted at the site-specific level in view of the moiety basicities of imatinib.
Mouse Model Systems of Autism Spectrum Disorder: Replicability and Informatics Signature (2019)

3. Abstract Background Phenotyping mouse model systems of human disease has proven to be a difficult task, with frequent poor inter- and intra-laboratory replicability and translatability, particularly in behavioral domains such as social and verbal function. However, establishing robust animal model systems with strong construct validity is of fundamental importance as they are central tools for understanding disease pathophysiology and developing therapeutics. To complete our studies of mouse model systems relevant to autism spectrum disorder (ASD), we present a replication of the main findings from our two published studies comprising five genetic mouse model systems of ASD. Methods To assess the robustness of our previous results, we chose the two model systems that showed the greatest phenotypic differences, the Shank3/F and Cntnap2 , and repeated assessments of general health, activity, and social behavior. We additionally explored all five model systems in the same framework, comparing all results obtained in this three-yearlong effort using informatics techniques to look for commonalities and differences. Results Results in the current study were very similar to our previously published results. The informatics signatures of the two model systems chosen for the replication showed that they were most distinguished by activity levels. Although the two model systems were opposite in this regard, those aspects of their social behavior not confounded by activity (vocalizations) were similar. Conclusions Our results showed high intra-laboratory replicability of results, even for those with effect sizes that were not particularly large, suggesting that discrepancies in the literature may be dependent on subtle differences in testing conditions, housing enrichment, or background strains and not so much on the variability of the behavioral phenotypes. The overall informatics analysis suggests two main classes of model systems that in some aspects lie on opposite ends of the behavioral spectrum, supporting the view that autism is not a unitary concept.
Demonstration of ultra-high time-bandwidth product in a non-reciprocal fiber-optic system (2018)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text D. Grassani, I. Cardea, S. J. Fabbri, J. Upham, R. W. Boyd, H. Altug, S. A. Schulz, K. L. Tsakmakidis, and C. Brès, "Demonstration of ultra-high time-bandwidth product in a non-reciprocal fiber-optic system," in Frontiers in Optics / Laser Science, OSA Technical Digest (Optica Publishing Group, 2018), paper JTu3A.32. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Degradation in mechanical properties by forging of particle reinforced aluminium matrix composites (1995)

The change in mechanical properties brought about by forging and heat treating were investigatedfor a SiC–6061 aluminium composite. The composite was prepared by the powder extrusion method. Hardness, strength, and ductility at room and elevated temperatures after various upsetting and heat treating processes were measured using small tensile specimens machined from upset materials. The hardness and strength of the composite at room and elevated temperature is decreased by upsetting, and in contrast the ductility is increased. The decrease in strength and the increase in ductility are maintained even after the post-upsetting heat treatment. In the process which includes upsetting at room temperature, the strength increases owing to strain hardening of the matrix, but this strain hardening disappears after heat treatment and as a result the strength decreases. The decrease in strength caused by upsetting can be explained by taking the degradation of the microstructure into consideration.MST/3012
Analysis and tolerancing of structured mid-spatial frequency errors in imaging systems (2010)

Structured mid-spatial frequency surface errors on aspheric optics can create ghost images and reduced contrast. This reduction in performance is shown to be non-linear with surface height using Fourier methods without small signal or statistical approximations. Tolerancing MSF errors can use traditional MTF metrics, and derives peak-to-valley limits on MSF surface height components.
Squeezed Vacuum Generation Using Symmetric Nonlinear Polarization Interferometer (2002)

Squeezed vacuum generation is demonstrated using an ultrashort pulse fiber laser and a symmetric nonlinear polarization interferometer (NOPI). In this system, the squeezed vacuum can be generated only by passing the ultrashort pulse along the optical fiber. Noise reduction of -1.7 dB below shot noise level is observed. Considering the effect of quantum efficiency in this system, the corresponding magnitude of squeezing is estimated to be -2.7 dB. The system is constructed with all fiber devices and is compact, stable, and useful for practical applications.
Thermotropic Properties of Cholesteric Liquid Crystal from Hydroxypropyl Cellulose Mixed Esters (2015)

セルロース誘導体であるヒドロキシプロピルセルロース(HPC)に，塩化プロピオニルとクロロギ酸コレステロールの2種類の酸塩化物を用いたエステル化反応を行い，HPC混合エステルを合成した．得られた生成物を1H NMRで測定し，分子構造の定量的な解析を行った．1H NMRの結果から，HPC側鎖に対する官能基の置換度，すなわちエステル化度を算出する方法を提案し，これに従いプロピオニル基とコレステリル基のHPC側鎖への導入量を算出した．これらの官能基を化学修飾したHPC混合エステルは，サーモトロピックなコレステリック液晶性を示した．HPCのヒドロキシ基に対して4.7%コレステリル基を導入し，残りをプロピオニル基で化学修飾したHPC混合エステルについて昇温過程における透過スペクトルを測定したところ，30°Cから80°Cの比較的低い温度においてブラッグ反射が発現し，温度を制御することでブラッグ反射のピーク波長が400 nmから800 nmの全可視波長域でシフトすることを見いだした．
Bis-Benzimidazole Hits against Naegleria fowleri Discovered with New High-Throughput Screens (2015)

Naegleria fowleri is a pathogenic free-living amoeba (FLA) that causes an acute fatal disease known as primary amoebic meningoencephalitis (PAM). The major problem for infections with any pathogenic FLA is a lack of effective therapeutics, since PAM has a case mortality rate approaching 99%. Clearly, new drugs that are potent and have rapid onset of action are needed to enhance the treatment regimens for PAM. Diamidines have demonstrated potency against multiple pathogens, including FLA, and are known to cross the blood-brain barrier to cure other protozoan diseases of the central nervous system. Therefore, amidino derivatives serve as an important chemotype for discovery of new drugs. In this study, we validated two new in vitro assays suitable for medium- or high-throughput drug discovery and used these for N. fowleri. We next screened over 150 amidino derivatives of multiple structural classes and identified two hit series with nM potency that are suitable for further lead optimization as new drugs for this neglected disease. These include both mono- and diamidino derivatives, with the most potent compound (DB173) having a 50% inhibitory concentration (IC50) of 177 nM. Similarly, we identified 10 additional analogues with IC50s of <1 μM, with many of these having reasonable selectivity indices. The most potent hits were >500 times more potent than pentamidine. In summary, the mono- and diamidino derivatives offer potential for lead optimization to develop new drugs to treat central nervous system infections with N. fowleri.
Bird Control in Vineyards Using Alarm and Distress Calls (2007)

Certain species of birds are pests for winegrape growers, including the house finch (<i>Carpodacus mexicanus</i>), American robin (<i>Turdus migratorius</i>), and European starling (<i>Sturnus vulgaris</i>) in California. Our objectives were to evaluate the effectiveness of different alarm and distress calls at hazing these species, to determine a protocol for use of broadcast calls in the field, and to measure the effectiveness of control. Species-specific alarm and distress calls from birds were collected. Based on call testing and bird activity surveys, four starling calls, three finch calls, and one robin call were selected for use with the broadcast units. The units were deployed around veraison at a density of 0.6 ha per broadcast unit, concentrated on the perimeter of the vineyard, and moved weekly in a fixed pattern. Three control strategies were compared: netting, conventional methods (reflective tape, propane cannons, pyrotechnics), and conventional methods supplemented with broadcast alarm and distress calls. Three different regions were selected in the Carneros AVA and three commercial Pinot noir vineyards were chosen in each region to test the control strategies. Damage data were measured over two consecutive seasons, year 1 to evaluate the effect of treatments without broadcast calls and year 2 to determine the effect of broadcast calls. Results indicated that broadcast distress calls added to conventional methods significantly reduced damage compared with conventional control (5.7% vs. 13.0%). Netting yielded the least damage (2.3%).
Software methods for fast hashing (2015)

The carry-less multiplication instruction, PCLMULQDQ, is a relatively recent addition to the x86-64 instructions set. It multiplies two binary polynomials of degree , using arithmetic, and produces a polynomial of degree , stored in a -bit register. PCLMULQDQ is intended to speed up computations in , which are used for AES-GCM authenticated encryption. We show here how PCLMULQDQ can be used for efficient software implementation of a -bit hash function that has a low collision probability. While a -bit hash is normally not a meaningful security primitive, the discussed hashing algorithm can be leveraged for other usages that enjoy fast hashing, e.g., querying/maintaining databases. On the latest Intel architecture (Codename Broadwell), our hash function can process messages at the rate of cycles per byte.
Simultaneous mixing and pumping using asymmetric microelectrodes (2007)

This study proposes ideas for simultaneous mixing and pumping using asymmetric microelectrode arrays. The driving force of the mixing and pumping was based on electroosmotic flows induced by alternating current (ac) electric fields on asymmetric microelectrodes. The key idea was to bend/incline the microelectrodes like diagonal/herringbone shapes. Four patterns of the asymmetric electrode arrays were considered depending on the shape of electrode arrays. For the diagonal shape, repeated and staggered patterns of the electrode arrays were studied. For the herringbone shape, diverging and converging patterns were examined. These microelectrode patterns forced fluid flows in the lateral direction leading to mixing and in the channel direction leading to pumping. Three-dimensional numerical simulations were carried out using the linear theories of ac electro-osmosis. The performances of the mixing and pumping were assessed in terms of the mixing efficiency and the pumping flow rate. The results indicated that the helical flow motions induced by the electrode arrays play a significant role in the mixing enhancement. The pumping performance was influenced by the slip velocity at the center region of the channel compared to that near the side walls.
Comparison of Coap and UW-19 Protocols for Dogs with Multicentric Lymphoma (2007)

Use of a long-term doxorubicin-containing sequential combination chemotherapy protocol is associated with a decreased risk of relapse and death relative to a non-doxorubicin-containing protocol.
Diels‐Alder Adducts From 4‐O‐Acetyl‐6‐Demethoxy‐N‐Formyl‐β‐Dihydro‐N‐Northebaine With Methyl Vinyl Ketone and Nitroethene (Chemistry of Opium Alkaloids, Part XXIX) (1989)

Abstract Reductive epoxy ring scission of 6‐demethoxy‐ N ‐northebaine (5) with zinc and potassium hydroxide gave a 85:15 mixture of 6a and its non‐conjugated isomer. Formylation with triethyl orthoformate, followed by acetylation with acetic anhydride in the presence of 4‐(dimethylamino)pyridine gave a 4:1 mixture of the title compound 6c and its non‐conjugated isomer in 80% overall yield. Diels‐Alder reaction of 6c with methyl vinyl ketone afforded a 2:1 mixture of 7β‐acetyl‐and 8β‐acetyl‐6β, 14β‐ethenomorphinan 7 and 8a. Cycloaddition of nitroethene yielded the 8β‐nitro‐6β, 14β‐ethenomorphinan 8b as major product. N ‐Demethylation of 2b, the 4‐ O ‐phenyl ether of 6‐demethoxy‐β‐dihydrothebaine (2a), with diethyl azodicarboxylate failed to give the N ‐norcompound.
Identification of RFLP markers linked to the H1 gene conferring resistance to the potato cyst nematode Globodera rostochiensis (1993)

The H1 gene from Solanum tuberosum ssp. andigena confers high levels of resistance to the potato cyst nematode Globodera rostochiensis and is used extensively in potato breeding. Using a dihaploid segregating population, a search was conducted for linkage between this gene and markers on the potato/tomato RFLP map. A total of 60 RFLP markers covering the entire genome were screened on bulk resistant and susceptible segregants. Linkage was indicated for eight markers on chromosome 5. Individual plant analysis placed the closest marker, CD78, at a maximum map distance of 2.7 cM from H1. A molecular marker for the H1 should be useful both as a correlative screening tool for incorporation of resistance into new cultivars and as starting point for map-based cloning of this important gene.
Relationship between Ca2+ concentration and the properties of codoped GGAG:Ce scintillators (2014)

Codoping is a method of current interest for modifying the properties of scintillators. The study reported here explores the effect of codoping on cerium doped Gd <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> Ga <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">12</sub> (GGAG:Ce) crystals with various concentrations of Ca. These single crystals were grown via the Czochralski technique with Ce concentrations fixed at 0.2 at% and Ca concentrations ranging from 0.1 at% to 0.4 at% in the initial melt. The relationship between dopant concentration and light yield and scintillation decay times was determined.
ChemInform Abstract: THE USE OF L‐TARTARIC ACID IN THE SYNTHESIS OF ENANTIOMERICALLY PURE COMPOUNDS: SYNTHESIS OF 4‐O‐BENZYL‐2,3‐DIDEOXY‐L‐THREO‐HEX‐2‐ENONO‐1,5‐LACTONE (1985)

Abstract L‐Wfeinsäuredimethylester (I) wird in das enantiomerenreine Lacton (VI) übergeführt, das als Baustein verschiedener Naturprodukte auftritt.
Convenient synthesis of Cu3(BTC)2 encapsulated Keggin heteropolyacid nanomaterial for application in catalysis (2010)

Nanomaterial of Cu(3)(BTC)(2) (BTC = benzene tricarboxylic acid) incorporating Keggin heteropolyacid conveniently prepared at room temperature and recovered by freeze drying outperforms ultrastable Y zeolite in acid catalysed esterification reaction.
6LoWPAN Backbone Router (2013)

ISA100.11a is a Working Group at the ISA SP100 standard committee
that covers Wireless Systems for Industrial Automation and Process
Control. The WG is mandated to design a scalable, industrial grade
LowPAN for devices such as sensors, valves, and actuators. The
upcoming standard uses the 6LoWPAN format for the network header. It
also introduces the concept of a Backbone Router to merge small
LoWPANs via a high speed transit and scale the ISA100.11a network.
This paper proposes an IPv6 version of the Backbone Router concept.
HANDS18: Methods, Techniques and Applications for Hand Observation (2018)

This report outlines the proceedings of the Fourth International Workshop on Observing and Understanding Hands in Action (HANDS 2018). The fourth instantiation of this workshop attracted significant interest from both academia and the industry. The program of the workshop included regular papers that are published as the workshop's proceedings, extended abstracts, invited posters, and invited talks. Topics of the submitted works and invited talks and posters included novel methods for hand pose estimation from RGB, depth, or skeletal data, datasets for special cases and real-world applications, and techniques for hand motion re-targeting and hand gesture recognition. The invited speakers are leaders in their respective areas of specialization, coming from both industry and academia. The main conclusions that can be drawn are the turn of the community towards RGB data and the maturation of some methods and techniques, which in turn has led to increasing interest for real-world applications.
The proliferation rate paradox in antimitotic chemotherapy (2011)

Cytotoxic cancer chemotherapy drugs are believed to gain selectivity by targeting cells that proliferate rapidly. However, the proliferation rate is low in many chemosensitive human cancers, and it is not clear how a drug that only kills dividing cells could promote tumor regression. Four potential solutions to this “proliferation rate paradox” are discussed for the microtubule-stabilizing drug paclitaxel: drug retention in tumors, killing of quiescent cells, targeting of noncancer cells in the tumor, and bystander effects. Testing these potential mechanisms of drug action will facilitate rational improvement of antimitotic chemotherapy and perhaps cytotoxic chemotherapy more generally.