gebhart/patrepeval huggingface dataset:
Vehicle control synthesis using phase portraits of planar dynamics (2018)

Phase portraits provide control system designers strong graphical insight into nonlinear system dynamics. These plots readily display vehicle stability properties and map equilibrium point locations and movement to changing parameters and system inputs. This paper extends the usage of phase portraits in vehicle dynamics to control synthesis by illustrating the relationship between the boundaries of stable vehicle operation and the state derivative isoclines in the yaw rate–sideslip phase plane. Closed-loop phase portraits demonstrate the potential for augmenting a vehicle's open-loop dynamics through steering and braking. The paper concludes by applying phase portrait analysis to an envelope control algorithm for yaw stability and a sliding surface controller for stabilising a saddle point equilibrium in drifting.
Monovalent virus-like particle vaccine protects guinea pigs and nonhuman primates against infection with multiple Marburg viruses (2008)

Musoke mVLPs are effective at inducing broad heterologous immunity and protection against multiple MARV isolates.
Nitric Oxide Modulates Leukocyte—Endothelial Cell Adhesion (2000)

Although the role of leukocytes in certain inflammatory diseases (e.g., arthritis, inflammatory bowel diseases) has long been appreciated, there is a large body of recent evidence that implicates leukocytes in a number of other pathological conditions, including atherosclerosis, hypertension, ischemia—reperfusion injury, venous thrombosis, and gastric ulceration. The recognition that a leukocyte must first adhere to vascular endothelium before it can exert its deleterious effects on blood vessels and neighboring parenchymal cells has led to an intensive effort to define the factors that influence the ability of leukocytes to adhere to endothelial cells. Data derived from both in vitro and in vivo models of leukocyte—endothelial cell adhesion invoke a role for several factors in the modulation of this cell-adhesion process. These factors include adhesion glycoproteins that are expressed on the surface of activated leukocytes and endothelial cells, hydrodynamic dispersal forces (e.g., shear rate) that are generated by the movement of blood through the circulation, and some products of leukocyte and endothelial cell activation.
NRL glasses for multispectral optics designs (Conference Presentation) (2018)

There is a strong desire to reduce size and weight of single and multiband IR imaging systems in ISR operations on hand-held, helmet mounted or airborne platforms. NRL is developing new IR glasses that transmit from 0.9 to > 12 µm in wavelength, with refractive index ranging from 2.38 to 3.17, to expand the glass map and provide compact solutions to multispectral imaging systems. These glasses were specifically designed to have comparable glass molding temperatures and thermal properties so that they can be laminated and co-molded into optics with reduced number of air-glass interfaces (lower Fresnel reflection losses). These new NRL glasses also have negative or very low dn/dT, making it easier to athermalize the optical system. Our multispectral optics designs using these new materials demonstrate reduced size, complexity and improved performance. The glass database is now available for distribution. Some of the NRL glasses are also available commercially. This presentation will cover discussions on the new optical materials, multispectral designs, as well fabrication and characterization of new optics.
Embedded Memory Hierarchy Exploration Based on Magnetic Random Access Memory (2014)

Static random access memory (SRAM) is the most commonly employed semiconductor in the design of on-chip processor memory. However, it is unlikely that the SRAM technology will have a cell size that will continue to scale below 45 nm, due to the leakage current that is caused by the quantum tunneling effect. Magnetic random access memory (MRAM) is a candidate technology to replace SRAM, assuming appropriate dimensioning given an operating threshold voltage. The write current of spin transfer torque (STT)-MRAM is a known limitation; however, this has been recently mitigated by leveraging perpendicular magnetic tunneling junctions. In this article, we present a comprehensive comparison of spin transfer torque-MRAM (STT-MRAM) and SRAM cache set banks. The non-volatility of STT-MRAM allows the definition of new instant on/off policies and leakage current optimizations. Through our experiments, we demonstrate that STT-MRAM is a candidate for the memory hierarchy of embedded systems, due to the higher densities and reduced leakage of MRAM.We demonstrate that adopting STT-MRAM in L1 and L2 caches mitigates the impact of higher write latencies and increased current draw due to the use of MRAM. With the correct system-on-chip (SoC) design, we believe that STT-MRAM is a viable alternative to SRAM, which minimizes leakage current and the total power consumed by the SoC.
Physiological Properties and Salmonella Growth Inhibition of Probiotic Bacillus Strains Isolated from Environmental and Poultry Sources (2013)

The objective of the present study was to describe the physiological properties of seven potential probiotic strains of Bacillus spp. Isolates were characterized morphologically, biochemically, and by 16S rRNA sequence analyses for identification. Tolerance to acidic pH, high osmotic concentrations of NaCl, and bile salts were tested. Isolates were also evaluated for their ability to metabolize different carbohydrates sources. The antimicrobial sensitivity profiles were determined. Inhibition of gastrointestinal Salmonella colonization in an avian model was also evaluated. Five strains of Bacillus were tolerant to acidic conditions (pH 2.0) and all strains were tolerant to a high osmotic pressure (NaCl at 6.5%). Moreover, all strains were able to tolerate concentration of 0.037% bile salts after 24 h of incubation. Three strains were able to significantly reduce Salmonella Typhimurium levels in the crop and in the ceca of broiler-type chickens. Among the 12 antibiotics tested for antibiotic resistance, all strains were resistant to bacitracin and susceptible to gentamycin, neomycin, ormethoprim, triple sulfa, and spectinomycin. Bacterial spore formers have been shown to prevent gastrointestinal diseases in animals and humans. The results obtained in this study show important characteristics to be evaluated when selecting Bacillus spp. candidates to be used as probiotics.
A new flux and stator resistance identifier for AC drive systems (1996)

The effect of stator resistance on AC drive performance is analyzed for flux vector and indirect field-oriented controllers. A new technique-the back electromagnetic force (BEMF) detector-for reducing the adverse effects of stator resistance on field-oriented control is presented and evaluated through simulation and experimental results. The BEMF detector is shown to reduce the impact of the stator resistance variations and also provide an estimate of the stator resistance. The detector is compatible with most control strategies and with or without position feedback.
Cyclic Variations of 3-Quinolinecarboxamides and Effects on Antiherpetic Activity (1995)

Supported by the antiherpetic properties of 3-quinolinecarboxamides and the importance of the planar intramolecular H-bonded beta-keto amide pharmacophore, a series of novel conformationally rigid analogues that contain a heterocyclic bridge between the 3- and 4-positions of the quinoline ring have been evaluated. Two isoxazolo-fused derivatives 17 and 23 displayed good in vitro antiherpetic potency that was similar to that of 1, the 3-quinolinecarboxamide that served as the comparison structure for this study. The pyrazolo, pyrrolo, and pyrimido derivatives showed considerably less or no activity. In vitro activity did not translate to in vivo efficacy. For 17, the lack of in vivo activity is likely a consequence of insufficient plasma drug levels (both Cmax and duration) in mice relative to the MIC versus HSV-2.
What does the Ternus display tell us about motion processing in human vision? (2010)

The Ternus display is a moving visual stimulus that elicits two very different percepts, according to the length of the interstimulus interval (ISI) between each frame of the motion sequence. These two percepts, referred to as element and group motion, have previously been analysed in terms of the operation of a low-level, dedicated short-range motion process (in the case of element motion), and of a higher-level, attentional long-range motion process (in the case of group motion). We used a Ternus display to examine a more recent dichotomy, the division of stimuli into 1st-order and 2nd-order. Recent research suggests that moving 2nd-order stimuli are analysed only via long-range motion processing. We showed that Ternus displays comprised of elements defined by either 1st-order or 2nd-order characteristics exhibit both element and group motion, implying that 2nd-order stimuli are amenable to analysis by both the short-range and long-range processes. However, a second experiment demonstrated that both element and group motion are, in fact, mediated solely by a process sensitive to changes in the spatial appearance of the Ternus elements. In light of this, it appears that Ternus displays tell us nothing about specific low-level motion processing, implying that previous studies using Ternus displays require reinterpretation. A third experiment revealed that the orientation and spatial frequency discrimination of the process underlying the analysis of Ternus displays was far worse than thresholds for spatial vision. We conclude that Ternus displays are analysed via a long-range motion, or feature-tracking, process, and that this process is distinct from spatial vision.
Role of the 6‐20 disulfide bridge in the structure and activity of epidermal growth factor (1998)

Two synthetic analogues of murine epidermal growth factor, [Abu6, 20] mEGF4-48 (where Abu denotes amino-butyric acid) and [G1, M3, K21, H40] mEGF1-48, have been investigated by NMR spectroscopy. [Abu6, 20] mEGF4-48 was designed to determine the contribution of the 6-20 disulfide bridge to the structure and function of mEGF. The overall structure of this analogue was similar to that of native mEGF, indicating that the loss of the 6-20 disulfide bridge did not affect the global fold of the molecule. Significant structural differences were observed near the N-terminus, however, with the direction of the polypeptide chain between residues four and nine being altered such that these residues were now located on the opposite face of the main beta-sheet from their position in native mEGF. Thermal denaturation experiments also showed that the structure of [Abu6, 20] mEGF4-48 was less stable than that of mEGF. Removal of this disulfide bridge resulted in a significant loss of both mitogenic activity in Balb/c 3T3 cells and receptor binding on A431 cells compared with native mEGF and mEGF4-48, implying that the structural changes in [Abu6, 20] mEGF4-48, although limited to the N-terminus, were sufficient to interfere with receptor binding. The loss of binding affinity probably arose mainly from steric interactions of the dislocated N-terminal region with part of the receptor binding surface of EGF. [G1, M3, K21, H40] mEGF1-48 was also synthesized in order to compare the synthetic polypeptide with the corresponding product of recombinant expression. Its mitogenic activity in Balb/c 3T3 cells was similar to that of native mEGF and analysis of its 1H chemical shifts suggested that its structure was also very similar to native.
CT and MR imaging in the staging of colorectal carcinoma: report of the Radiology Diagnostic Oncology Group II. (1996)

CT was more accurate than MR imaging in detection and characterization of transmural penetration of rectal tumors. Recent technologic advances in MR imaging may affect these results.
Nobel Fast Catadioptric Objective with Wide Field of View (2010)

Using the Simultaneous Multiple Surface method in 2D (SMS2D), we present a fast catadioptric objective with a wide field of view (125°×96°) designed for a microbolometer detector with 640×480 pixels and 25 microns pixel pitch.
Monolayered octopus-porphyrin vesicle: microstructure and oxygen-binding in aqueous medium (1995)

The amphiphilic tetraphenylporphin derivative having four dialkylglycerophosphoctoline groups on both sides of the ring plane (octopus-porphyrin) forms spherical monolayered vesicle membranas in water with diameters of ca. 100 nm; the vesicle constituted by octopus-porphyrinatoiron(II)/1-dodecyl-2-methyiimdazole (DMIm) can reversibly bind dioxygen at 25 °C.
Transcriptomic profiling of sex-specific olfactory neurons reveals subset-specific receptor expression in Caenorhabditis elegans (2023)

The nematode Caenorhabditis elegans utilizes chemosensation to navigate an ever-changing environment for its survival. A class of secreted small-molecule pheromones, termed ascarosides, play an important role in olfactory perception by affecting biological functions ranging from development to behavior. The ascaroside #8 (ascr#8) mediates sex-specific behaviors, driving avoidance in hermaphrodites and attraction in males. Males sense ascr#8 via the ciliated male-specific cephalic sensory (CEM) neurons, which exhibit radial symmetry along dorsal-ventral and left-right axes. Calcium imaging studies suggest a complex neural coding mechanism that translates stochastic physiological responses in these neurons to reliable behavioral outputs. To test the hypothesis that neurophysiological complexity arises from differential expression of genes, we performed cell-specific transcriptomic profiling; this revealed between 18 and 62 genes with at least twofold higher expression in a specific CEM neuron subtype vs both other CEM neurons and adult males. These included two G protein-coupled receptor (GPCR) genes, srw-97 and dmsr-12, that were specifically expressed in nonoverlapping subsets of CEM neurons and whose expression was confirmed by GFP reporter analysis. Single CRISPR-Cas9 knockouts of either srw-97 or dmsr-12 resulted in partial defects, while a double knockout of both srw-97 and dmsr-12 completely abolished the attractive response to ascr#8. Together, our results suggest that the evolutionarily distinct GPCRs SRW-97 and DMSR-12 act nonredundantly in discrete olfactory neurons to facilitate male-specific sensation of ascr#8.
Hom s 4, an IgE-Reactive Autoantigen Belonging to a New Subfamily of Calcium-Binding Proteins, Can Induce Th Cell Type 1-Mediated Autoreactivity (2005)

Skin inflammation in atopic dermatitis starts with Th2 and IgE-mediated responses against exogenous allergens and, for unknown reasons, resembles features of a Th1-driven reaction in the chronic stages. We report the characterization of a human protein, Hom s 4, recognized by IgE autoantibodies from atopic dermatitis patients. The complete Hom s 4 cDNA codes for a 54-kDa basic protein containing two typical calcium-binding domains separated by an unusually long alpha-helical domain. Therefore, Hom s 4 and homologous proteins found by sequence comparison in mice, fruit flies, and nematodes constitute a novel subfamily of calcium-binding proteins. Using Hom s 4-specific Abs, it is demonstrated that the protein is strongly expressed within epidermal keratinocytes and dermal endothelial cells. Purified Hom s 4 showed IgE cross-reactivity with exogenous calcium-binding allergens from plants and fish but, in contrast to the exogenous allergens, induced only weak histamine release from patient basophils. However, the analysis of Hom s 4-specific cytokine and humoral immune responses indicated that Hom s 4 strongly induces Th1 responses which are accompanied by the release of IFN-gamma, a cytokine implicated in epithelial cell damage. Hom s 4-induced IFN-gamma production was found in normal individuals, in patients with chronic inflammatory skin diseases and in Th2-prone atopic persons, suggesting that Hom s 4 represents a protein with an intrinsic property to induce Th1-mediated autoreactivity. It may thus contribute to chronic skin inflammation in atopic as well as in nonatopic persons.
Assay of phospholipases A2 and their inhibitors by kinetic analysis in the scooting mode (1992)

Several cellular processes are regulated by interfacial catalysis on biomembrane surfaces. Phospholipases A(2) (PLA(2)) are interesting not only as prototypes for interfacial catalysis, but also because they mobilize precursors for the biosynthesis of eicosanoids and platelet activating factor, and these agents ultimately control a wide range of secretory and inflammatory processes. Since PLA(2) carry out their catalytic function at membrane surfaces, the kinetics of these enzymes depends on what the enzyme 'sees' at the interface, and thus the observed rate is profoundly influenced by the organization and dynamics of the lipidwater interface ('quality of the interface'). In this review we elaborate the advantages of monitoring interfacial catalysis in the scooting mode, that is, under the conditions where the enzyme remains bound to vesicles for several thousand catalytic turnover cycles. Such a highly processive catalytic turnover in the scooting mode is useful for a rigorous and quantitative characterization of the kinetics of interfacial catalysis. This analysis is now extended to provide insights into designing strategy for PLA(2) assays and screens for their inhibitors.
Deep scattering spectra with deep neural networks for LVCSR tasks (2014)

Log-mel filterbank features, which are commonly used features for CNNs, can remove higher-resolution information from the speech signal. A novel technique, known as Deep Scattering Spectrum (DSS), addresses this issue and looks to preserve this information. DSS features have shown promise on TIMIT, both for classification and recognition. In this paper, we extend the use of DSS features for LVCSR tasks. First, we explore the optimal multi-resolution time and frequency scattering operations for LVCSR tasks. Next, we explore techniques to reduce the dimension of the DSS features. We also incorporate speaker adaptation techniques into the DSS features. Results on a 50 and 430 hour English Broadcast News task show that the DSS features provide between a 4-7% relative improvement in WER over log-mel features, within a state-of-the-art CNN framework which incorporates speaker-adaptation and sequence training. Finally, we show that DSS features are similar to multi-resolution log-mel + MFCCs, and similar improvements can be obtained with this representation.
Transformation of Sequential Hospital and Outpatient Laboratory Data into Between-Day Reference Change Values (2021)

Our RCVAlternate values integrate known and unknown components of analytic, biologic, and preanalytic variation, and depict the variations observed by clinical teams that make medical decisions based on the test values. The RCVAlternate values are similar to the RCVhealthy values derived from known components of variation and suggest further studies to better understand the results being generated on actual patients tested in typical laboratory environments.
In vivo transgene activation from an HSV-based gene therapy vector by GAL4:vp16. (1996)

Herpes simplex virus type 1 (HSV-1) has many attributes which make it attractive as a base for the development of vectors for the delivery of transgenes to the nervous system. In this report we describe the adaptation of the bipartite GAL4:VP16 transactivation system to replication-deficient HSV vectors. We demonstrate that the recombinant transactivator GAL4:VP16 produced from a replication-deficient HSV vector is capable of activating transcription of a reporter gene using a synthetic promoter consisting of GAL4 binding sites and the TATA box of the adenovirus E1b gene. Activation by vector produced GAL:VP16 was demonstrated with the recombinant promoter/reporter gene cassette in the infected cell chromosome, in the genome of a second virus infecting the same cells and with a single vector engineered to produce both GAL4:VP16 transactivator and to contain a recombinant promoter/reporter gene cassette. Furthermore, the double recombinant virus also produced the reporter gene product in neurons after direct intracranial inoculation into rat hippocampus. This system may be used to extend and improve promoter function in HSV gene transfer vectors in vivo.
Extreme laser pulses for non-thermal fusion ignition of hydrogen–boron for clean and low-cost energy (2018)

Abstract After achieving significant research results on laser-driven boron fusion, the essential facts are presented how the classical very low-energy gains of the initially known thermal ignition conditions for fusion of hydrogen (H) with the boron isotope 11 (HB11 fusion) were bridged by nine orders of magnitudes in agreement with experiments. This is possible under extreme non-thermal equilibrium conditions for ignition by &gt;10 PW-ps laser pulses of extreme power and nonlinear conditions. This low-temperature clean and low-cost fusion energy generation is in crucial contrast to local thermal equilibrium conditions with the advantage to avoid the difficulties of the usual problems with extremely high temperatures.
Light harvesting and energy transfer within coumarin‐labeled polymers (2001)

Linear copolymers that have pendant coumarin-2 and coumarin-343 chromophores were prepared as analogues to previously synthesized light-harvesting dendrimers. The chromophore ratios within these polymers were maintained similar to those of the various generation dendrimers to investigate the effect of polymer architecture on the energy-transfer efficiency between the coumarin-2 donors and coumarin-343 acceptors. Both physical and photophysical properties of these polymers were analyzed and compared to those of the analogous dendrimers. Energy-transfer efficiencies were relatively high in the polymers; however, deleterious excimer formation between the coumarin-343 chromophores diminished the quantum yield of fluorescence of the polymers when compared to the analogous dendrimers. Overall, it was found that the ultimate performance of the dendritic light-harvesting antennae was superior to that of the polymeric analogues, but the polymers were more practical in terms of synthetic accessibility. © 2001 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 39: 1366–1373, 2001
Effect of adding hygroscopic salts on the analysis of the volatile fraction of cheese (2000)

We investigated the effect of adding hygroscopic salts on the analysis by dynamic headspace -gas chromatographymass spectrometry of the volatile fraction of cheese. We tested five salts: calcium chloride, magnesium sulfate, potassium carbonate, sodium chloride and sodium sulfate. Relative humidity of the headspace, pH value of the matrix, desorption of volatile components and their odor were modified differently according to the salt used. Adding magnesium sulfate or potassium carbonate respectively released carboxylic acids and amino compounds from the matrix, whereas calcium chloride restricted the overall desorption of the volatile components. Sodium sulfate and sodium chloride had little effect.