gebhart/patrepeval huggingface dataset:
Depth-based representations: Which coding format for 3D video broadcast applications? (2011)

3D Video (3DV) delivery standardization is currently ongoing in MPEG. Now time is to choose 3DV data representation format. What is at stake is the final quality for end-users, i.e. synthesized views' visual quality. We focus on two major rival depth-based formats, namely Multiview Video plus Depth (MVD) and Layered Depth Video (LDV). MVD can be considered as the basic depth-based 3DV format, generated by disparity estimation from multiview sequences. LDV is more sophisticated, with the compaction of multiview data into color- and depth-occlusions layers. We compare final views quality using MVD2 and LDV (both containing two color channels plus two depth components) coded with MVC at various compression ratios. Depending on the format, the appropriate synthesis process is performed to generate final stereoscopic pairs. Comparisons are provided in terms of SSIM and PSNR with respect to original views and to synthesized references (obtained without compression). Eventually, LDV outperforms significantly MVD when using state-of-the-art reference synthesis algorithms. Occlusions management before encoding is advantageous in comparison with handling redundant signals at decoder side. Besides, we observe that depth quantization does not induce much loss on the final view quality until a significant degradation level. Improvements in disparity estimation and view synthesis algorithms are therefore still expected during the remaining standardization steps.
A Simple and Green Procedure for the Conjugate Addition of Thiols to Conjugated Alkenes Employing Polyethylene Glycol (PEG) as an Efficient Recyclable Medium. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access the actual ChemInform Abstract, please click on HTML or PDF.
Endothelial transmigration hotspots limit vascular leakage through heterogeneous expression of ICAM1 (2022)

Abstract Upon inflammation, leukocytes leave the circulation by crossing the endothelial monolayer at specific transmigration ‘hotspot’ regions. Although these regions support leukocyte transmigration, their functionality is not clear. We found that endothelial hotspots function to limit vascular leakage during transmigration events. Using the photo-convertible probe mEos4b, we traced back and identified original endothelial transmigration hotspots. Using this method, we show that the heterogeneous distribution of ICAM-1 determines the location of the transmigration hotspot. Interestingly, loss of ICAM-1 heterogeneity either by CRISPR/Cas9-induced knockout of ICAM-1 or equalizing the distribution of ICAM-1 in all endothelial cells results in loss of TEM hotspots but not necessarily in reduced TEM events. Functionally, loss of endothelial hotspots results in increased vascular leakage during TEM. Mechanistically, we demonstrate that the 3 extracellular Ig-like domains of ICAM-1 are crucial for hotspot recognition. However, the intracellular tail of ICAM-1 and the 4 th Ig-like dimerization domain are not involved, indicating that intracellular signalling or ICAM-1 dimerization is not required for hotspot recognition. Together, we discovered that hotspots function to limit vascular leakage during inflammation-induced extravasation.
A Novel, Potent, Small Molecule AKT Inhibitor Exhibits Efficacy against Lung Cancer Cells <i>In Vitro</i> (2015)

BIA-6 is a novel, allosteric Akt inhibitor with potent anti-cancer activity in lung cancer cell lines, that effectively blocks the phosphoinositide-3 kinase/Akt pathway with a high margin selectivity towards normal cells.
Calmodulin-sensitive ATP-dependent Ca2+ transport across adipocyte plasma membranes. (1980)

An ATP-dependent transport system which is active at concentrations of free Ca2+ in the submicromolar range has been identified in adipocyte plasma membranes. The system appears to represent the functional component of the high affinity insulin-sensitive calcium-stimulated, magnesium-dependent adenosine triphosphatase preveiously described in the same preparation (Pershadsingh, H. A., and McDonald, J. M. (1979) Nature 281, 495-497). This ATP-dependent Ca2+ transport pump was stimulated approximately 3-fold by the Ca2+-dependent regulatory protein, calmodulin. This effect was confined to the plasma membrane since a similar effect was undetectable in the fraction enriched in endoplasmic reticulum. Calmodulin stimulation was dose-dependent but saturable with half-maximal activation occurring at 0.72 microgram/ml (43 nM). Calmodulin appeared to stimulate the system primarily by decreasing the apparent half-maximal saturation constant for free Ca2+ from 0.20 +/- 0.04 microM to 0.07 +/- 0.01 microM (n = 3). The Hill coefficient increased from 1.6 +/- 0.2 to 3.2 +/- 0.6 (n = 3), thus showing an increased positive cooperativity which allows the pump to be activated by an exceedingly narrow Ca2+ threshold in the presence of calmodulin. The calmodulin stimulation of the plasma membrane Ca2+ extrusion pump in adipocytes, working in opposition to metabolic signals which increase cytoplasmic Ca2+, could constitute a self-regulating negative feedback device for maintaining a low steady state level of intracellular Ca2+. This feedback system may be of critical importance in regulation of cellular metabolism by insulin.
Effect of personalized immunization with GNOS-PV02 of patients with hepatocellular carcinoma on TCR clonal expansion, tumor infiltration, and vaccine-specific reactivity. (2023)

2629 Background: Tumor-specific neoantigens can be identified from cancer biopsies and used to develop personalized therapeutic cancer vaccines (PTCV) to prime neoantigen-specific T cell responses. Here, we characterized the antitumor neoantigen-specific reactivity of tumor-infiltrating, high-frequency TCR clones in a patient treated with personalized therapeutic DNA cancer vaccine GNOS-PV02 in the ongoing GT-30 advanced hepatocellular carcinoma single-arm open-label multi-center phase Ib/IIa trial (NCT04251117). Methods: Paired blood and tumor biopsy samples from patient #8 enrolled in the GT-30 study were collected before and after treatment with GNOS-PV02 (1mg) + plasmid-encoded IL-12 (0.3mg) + Pembrolizumab (200mg). GNOS-PV02 and IL-12 were administered at Q3W for the first 4 doses, then, at Q9W. Pembrolizumab was administered Q3W. Neoantigen positivity was evaluated by IFNγ-ELISpot. TCRβ sequencing was performed on all 4 samples and single-cell TCR and transcriptome sequencing was performed from T cells isolated from the post-treatment blood sample. After vaccination, three newly identified TCRs in blood and tumor were inserted into a pMXs-IRES-GFP retroviral plasmid vector and used to generate engineered TCR T cells. Engineered T cells were tested against the neoantigens included in PTCV by flow cytometry. Results: The treatment resulted in a partial response with a decrease in tumor size of 44% by RECIST1.1. Five vaccine-encoded responding neoantigens were identified. Differential abundance frame network analysis revealed that 27 of 42 (64.28%) significantly expanded peripheral TCR clones were also found enriched in the tumors post-treatment. Importantly, we observed an increase in cumulative frequency (from 0.4 to 7.7%), and absolute numbers (from 3 to 14) of significantly expanded vaccine-specific TCR clones in the tumor. Increased TCR clonality confirmed a focused tumor repertoire response. Single-cell sequencing data analysis revealed that the 6 most expanded clones in blood were activated CD8+CD69+ T cells (81.82%). Three full TCR sequences from T cell clones newly present in the tumor post-vaccination were selected, synthesized and cloned. TCR-engineered patient-specific T cells showed a dose-dependent CD8+ and CD4+ T cell activation (CD69+) upon stimulation with a pool of epitopes covering all the neoantigens in the patient’s PTCV. Conclusions: PTCV treatment resulted in neoantigen-specific T cell responses, clonal expansion in the periphery and primary lesion, and tumor infiltration of T cells with an activated phenotype. TCR-engineered high-frequency T cells found in the tumor are reactive to PTCV-encoded neoantigens post-treatment. These results may account for the observed objective decrease in the primary tumor size.
Combining Experimental and DFT Investigation of the Mechanism Involved in Thermal Etching of Titanium Nitride Using Alternate Exposures of NbF5 and CCl4, or CCl4 Only (2021)

Abstract Thermally activated chemical vapor‐phase etching of titanium nitride (TiN) is studied by utilizing either alternate exposures of niobium pentafluoride (NbF 5 ) and carbon tetrachloride (CCl 4 ) or by using CCl 4 alone. Nitrogen (N 2 ) gas purge steps are carried out in between every reactant exposure. Titanium nitride is etched in a non‐self‐limiting way by NbF 5 –CCl 4 based binary chemistry or by CCl 4 at temperatures between 370 and 460 °C. Spectroscopic ellipsometry and a weight balance are used to calculate the etch per cycle. For the binary chemistry, an etch per cycle of ≈0.8 Å is obtained for 0.5 and 3 s long exposures of NbF 5 and CCl 4 , respectively at 460 °C. On the contrary, under the same conditions, the etch process with CCl 4 alone gives an etch per cycle of about 0.5 Å. In the CCl 4 ‐only etch process, the thickness of TiN films removed at 460 °C varies linearly with the number of etch cycles. Furthermore, CCl 4 alone is able to etch TiN selectively over other materials such as Al 2 O 3 , SiO 2 , and Si 3 N 4 . X‐ray photoelectron spectroscopy and bright field transmission electron microscopy are used for studying the post‐etch surfaces. To understand possible reaction products and energetics, first‐principles calculations are carried out with density functional theory. From thermochemical analysis of possible reaction models, it is found that NbF 5 alone cannot etch TiN while CCl 4 alone can etch it at high temperatures. The predicted byproducts of the reaction between the CCl 4 gas molecules and TiN surface are TiCl 3 and ClCN. Similarly, TiF 4 , NbFCl 3 , and ClCN are predicted to be the likely products when TiN is exposed to both NbF 5 and CCl 4 . A more favorable etch reaction is predicted when TiN is exposed to both NbF 5 and CCl 4 (Δ G = −2.7 eV at 640 K) as compared to exposure to CCl 4 only (Δ G = −2 eV at 640 K) process. This indicates that an enhanced etch rate is possible when TiN is exposed alternately to both NbF 5 and CCl 4 , which is in close agreement with the experimental results.
Peptide chemistry: Development of high performance liquid chromatography and capillary zone electrophoresis (1996)

The development of relatively non-compressible supporting media of small particle size as well as pumps that deliver constant flow rates at high pressures has enabled investigators to perform rapid, high resolution liquid chromatography for more than two decades. Studies initiated in this laboratory in 1975, evaluating the compatibility of unprotected peptides with commercially available chromatographic supports and development of solvent systems ultimately led to separations not previously observed with both synthetic peptides and native peptides from tissue extracts. It was rapidly realized however, that recovery of certain molecules could be problematic. To meet the challenges presented by the isolation of natural hormones (such as corticotropin releasing factor and growth hormone releasing hormone) and proteins (such as inhibin and activin) and the need for large quantities of highly purified peptides for clinical investigations, our group invested heavily in identifying new supports (high carbon loading and 300 A pore sizes) and solvent systems (triethylammonium phosphate and trifluoroacetic acid) compatible with reverse phase, size exclusion and ion exchange chromatographies from a practical and economical perspective. More recently, we have contributed to the identification of unusual buffer systems (inclusive of organic modifiers) compatible with capillary zone electrophoresis that will both modulate the capillaries' selectivity, increase resolution and serve as an orthogonal approach to determining peptide purity. From a pragmatic point of view, in this paper we highlight the original and timely contributions (technical and strategical) of this laboratory in the field of analytical and preparative high performance liquid chromatography and capillary zone electrophoresis of synthetic and native biologically active peptides and proteins over the past twenty years.
Confirmation of a large kinetic isotope effect in the low-temperature matrix reaction of diphenylcarbene with toluene (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConfirmation of a large kinetic isotope effect in the low-temperature matrix reaction of diphenylcarbene with tolueneT. G. Savino, N. Soundararajan, and M. S. PlatzCite this: J. Phys. Chem. 1986, 90, 5, 919–923Publication Date (Print):February 1, 1986Publication History Published online1 May 2002Published inissue 1 February 1986https://pubs.acs.org/doi/10.1021/j100277a042https://doi.org/10.1021/j100277a042research-articleACS PublicationsRequest reuse permissionsArticle Views56Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
New 68Ga AAZTA-bisphosphonates as potential bone imaging agents. (2016)

1380 Objectives In vivo positron emission tomography (PET) imaging of the bone using [68Ga] bisphosphonates may be a valuable tool for cancer diagnosis and monitoring therapeutic treatment. Previously, [68Ga]BPAMD, [68Ga]1, has been reported as a useful PET imaging agent for studying bone metastasis in cancer patients. We have developed new AAZTA (6-[bis(hydroxycarbonyl-methyl)amino]-1,4-bis(hydroxycarbonyl methyl)-6-methylperhydro-1,4-diazepine derivatives labeled with 68Ga ([68Ga]2, [68Ga]3 and [68Ga]4) as new bone targeting agents. Methods Phenoxy derivative of AAZTA (2,29-(6-(bis(carboxymethyl)amino)-6-((4-(2-carboxyethyl)phenoxy)methyl)-1,4-diazepane-1,4-diyl)diacetic acid), PhenA, 2, containing a bisphosphonate group (PhenA-BPAMD, 3, and PhenA-HBP, 4) were prepared. Labeling of these chelating agents with 68Ga was evaluated. Results The ligands reacted rapidly with [68Ga]GaCl3 eluted from a commercially available 68Ge/68Ga generator (pH 4, >95% room temperature in 5 min) to form [68Ga]PhenA-BPAMD, 3, and [68Ga]PhenA-HBP, 4. Formation of the complexes was not effected by the presence of Zn2+, Cu2+, Fe3+ and Sn2+ ( Conclusions New 68Ga bisphosphonates, [68Ga]3 and [68Ga]4, may be useful as bone imaging agents in conjunction with positron emission tomography (PET).
A power attack methodology to AES based on induced cache misses: procedure, evaluation and possible countermeasures (2006)

The need for fast but secure cryptographic systems is growing bigger. Therefore, dedicated hardware for cryptography is becoming a key issue for designers. With the spread of reconfigurable hardware such as FPGAs, embedded cryptographic hardware became cost-effective. Nevertheless, it is worthy to note that nowadays, even hardwired cryptographic algorithms are not safe. Attacks based on power consumption and electromagnetic Analysis, such as SPA, DPA and EMA have been successfully used to retrieve secret information stored in cryptographic devices. Besides performance in terms of area and throughput, designer of embedded cryptographic hardware must worry about the leakage of their implementations.\nThis paper deals with the leakage that occurs in the SW computation of AES on platforms equipepd with a cache memory through the miss events, which may allow to infer the secret key.
Transient Topographies of Ion Patterned Si(111) (2005)

The surface of high fluence ion-sputtered Si(111) was found to exhibit a rich variety of transient one- and two-dimensional topographies that may be exploited as tunable self-organized arrays of nanostructures. Such transient effects are only partially described by analytical models of sputter patterning. However, a discrete atom kinetic Monte Carlo simulation model incorporating curvature-dependent sputtering and surface diffusion reproduces many aspects of the transient morphological evolution, and clarifies the minimal model of sputter patterning.
The Proximal Tibia Loses Bone Mineral Density After Anterior Cruciate Ligament Injury: Measurement Technique and Validation of a Quantitative Computed Tomography Method (2021)

Descriptive diagnostic study, Level III.
Interplay of Structural and Optoelectronic Properties in Formamidinium Mixed Tin–Lead Triiodide Perovskites (2018)

Abstract Mixed lead–tin triiodide perovskites are promising absorber materials for low bandgap bottom cells in all‐perovskite tandem photovoltaic devices. Key structural and electronic properties of the FAPb 1− x Sn x I 3 perovskite are presented here as a function of lead:tin content across the alloy series. Temperature‐dependent photoluminescence and optical absorption measurements are used to identify changes in the bandgap and phase transition temperature. The large bandgap bowing parameter, a crucial element for the attainment of low bandgaps in this system, is shown to depend on the structural phase, reaching a value of 0.84 eV in the low‐temperature phase and 0.73 eV at room temperature. The parabolic nature of the bowing at all temperatures is compatible with a mechanism arising from bond bending to accommodate the random placement of unevenly sized lead and tin ions. Charge‐carrier recombination dynamics are shown to fall into two regimes. Tin‐rich compositions exhibit fast, monoexponential recombination that is almost temperature‐independent, in accordance with high levels of electrical doping. Lead‐rich compositions show slower, stretched‐exponential charge‐carrier recombination that is strongly temperature‐dependent, in accordance with a multiphonon assisted process. These results highlight the importance of structure and composition for control of bandgap bowing and charge‐carrier recombination mechanisms in low bandgap absorbers for all‐perovskite tandem solar cells.
Detection of 100 spots parallel DNA: DNA interactions on polymer-functionalized surfaces using surface plasmon resonance imaging (2005)

Surface plasmon resonance is a method well-known for its sensibility to refractive index variations at a metal-dielectric interface. Surface plasmon imaging is an extension of this method. It allows the local study of refractive index variations resulting from interfacial modifications on a metallic surface. This technique is suitable to monitor in parallel, in real time and without any label hundreds of molecular interactions. The study of DNA:DNA hybridization is one of its applications.
Oligomeric odd–even effect in liquid crystals (2019)

We demonstrate a novel oligomeric odd–even effect of mesogenic segments connected by flexible chains with an odd number of methylene groups.
Integrated all-optical phase-sensitive amplifier using the thermal nonlinearity (2017)

We demonstrate an all-optical phase-sensitive amplifier, a critical component in integrated circuits for all-optical computing. The amplifier is fabricated in amorphous silicon-on-insulator and relies on thermo-optic self-heating in a ring-loaded Mach-Zehnder interferometer. changing the power and phase of the bias input tunes the gain.
Windrow Cocomposting of Municipal Biosolids and Yard Waste (1995)

A total of four windrows with yard waste:biosolids ratios ranging from 5.0:1 to 1.2:1 by wet weight were operated over a six month period. The windrows were monitored for temperature, oxygen content, bulk density, particle size, compost characteristics (including metals, nutrients, pesticides, volatile solids, and moisture content), runoff characteristics, and odor potential. Based on study results, cocomposting should be employed at a yard waste:biosolids ratio greater than or equal to 3:1 in order to minimize odor and improve compost characteristics. Leaching of several metals was observed; however, only lead was observed in the runoff at concentrations above maximum contaminant levels.
Dalbavancin dosage adjustments not required for patients with mild to moderate renal impairment (2008)

Dalbavancin (DAL) is a novel semisynthetic glycopeptide in phase 3 clinical development that has activity against Gram(+) organisms, including resistant strains. Two doses given 1 week apart have been shown to be effective in complicated skin and soft tissue infections. A clinical study was performed to determine the need for dosage adjustments in subjects with mild to moderate renal impairment (RI).
Supplementary Materials from Preclinical Activity of SAR408701: A Novel Anti-CEACAM5–maytansinoid Antibody–drug Conjugate for the Treatment of CEACAM5-positive Epithelial Tumors (2023)

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Biofouling control in water by various UVC wavelengths and doses (2009)

UV light irradiation is being increasingly applied as a primary process for water disinfection, effectively used for inactivation of suspended (planktonic) cells. In this study, the use of UV irradiation was evaluated as a pretreatment strategy to control biofouling. The objective of this research was to elucidate the relative effectiveness of various targeted UV wavelengths and a polychromatic spectrum on bacterial inactivation and biofilm control. In a model system using Pseudomonas aeruginosa, the inactivation spectra corresponded to the DNA absorption spectra for all wavelengths between 220 and 280 nm, while wavelengths between 254 nm and 270 nm were the most effective for bacterial inactivation. Similar wavelengths of 254-260-270 nm were also more effective for biofilm control in most cases than targeted 239 and 280 nm. In addition, the prevention of biofilm formation by P. aeruginosa with a full polychromatic lamp was UV dose-dependent. It appears that biofilm control is improved when larger UV doses are given, while higher levels of inactivation are obtained when using a full polychromatic MP lamp. However, no significant differences were found between biofilms produced by bacteria that survived UV irradiation and biofilms produced by control bacteria at the same microbial counts. Moreover, the experiments showed that biofilm prevention depends on the post-treatment incubation time and nutrient availability, in addition to targeted wavelengths, UV spectrum and UV dose.