gebhart/patrepeval huggingface dataset:
Performance consideration of three-dimensional optoelectronic interconnection for intra-multichip-module clock signal distribution (1997)

The structure, fabrication, and theory of a three-dimensional planarized optoelectronic clock signal distribution device, based on a thin light-guiding substrate in conjunction with a two-dimensional polymer holographic grating array, are described. We have demonstrated previously a 25-GHz 1-to-42 (6 x 7) highly parallel fan-out interconnect with a signal-to-noise ratio of 10 dB. We present theoretical research that focuses on generating a globally uniform fan-out distribution. An objective function aimed at equalizing the intensities among the fan-out beams is established. For an arbitrary M x N fan-out distribution, there are M + N + 1 sets of holograms needed to be recorded independently to provide the required equal fan-outs. The efficiency of each hologram is determined precisely. The angular misalignment, wavelength dispersion, and spot-size problems are discussed further, together with their tolerance requirements on the size of the photoreceivers integrated on the multichip modules. Employment of 0.25-pitch gradient index (GRIN) lenses as a collimator and as a focusing element is demonstrated experimentally. Optical beam profile manipulation and packaging tolerance are enhanced greatly with GRIN lenses. Finally, clock skew problems associated with the proposed system are discussed, and schemes to minimize the skew are proposed.
ChemInform Abstract: Synthetic Studies on Quassinoids: Total Synthesis of (.+‐.)‐ Chaparrinone. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
EXTRACTION AND MATCHING OF SYMBOLIC CONTOUR GRAPHS (2003)

We describe an object recognition system based on symbolic contour graphs. The image to be analyzed is transformed into a graph with object corners as vertices and connecting contours as edges. Image corners are determined using a robust multiscale corner detector. Edges are constructed by line-following between corners based on evidence from the multiscale Gabor wavelet transform. Model matching is done by finding subgraph isomorphisms in the image graph. The complexity of the algorithm is reduced by labeling vertices and edges, whereby the choice of labels also makes the recognition system invariant under translation, rotation and scaling. We provide experimental evidence and theoretical arguments that the matching complexity is below O(#V 3 ), and show that the system is competitive with other graph-based matching systems.
Full-vectorial coupled mode theory for the evaluation of macro-bending loss in multimode fibers. application to the hollow-core photonic bandgap fibers (2008)

In the hollow core photonic bandgap fibers, modal losses are strongly differentiated, potentially enabling effectively single mode guidance. However, in the presence of macro-bending, due to mode coupling, power in the low-loss mode launched into a bend is partially transferred into the modes with higher losses, thus resulting in increased propagation loss, and degradation of the beam quality. We show that coupled mode theory formulated in the curvilinear coordinates associated with a bend can describe correctly both the bending induced loss and beam degradation. Suggested approach works both in absorption dominated regime in which fiber modes are square integrable over the fiber crossection, as well as in radiation dominated regime in which leaky modes are not square integrable. It is important to stress that for multimode fibers, full-vectorial coupled mode theory developed in this work is not a simple approximation, but it is on par with such "exact" numerical approaches as finite element and finite difference methods for prediction of macro-bending induced losses.
Supplementary Materials and Methods, Supplementary Figure Legend, Supplementary Table 1 from The Ovarian Cancer Chemokine Landscape Is Conducive to Homing of Vaccine-Primed and CD3/CD28–Costimulated T Cells Prepared for Adoptive Therapy (2023)

&lt;p&gt;Supplementary Materials and Methods, Supplementary Figure Legend, Supplementary Table 1. Supplementary Table 1: Cell line origin and characteristics&lt;/p&gt;
IPH6501 Is a Novel NKp46-Targeting Tetraspecific Antibody-Based Natural Killer Cell Engager Therapeutic (ANKET) Armed with a Non-Alpha IL-2 Variant and Developed for the Treatment of CD20-Positive Malignancies (2022)

International audience
Mortality during Treatment of Patients with Advanced Hodgkin’s Lymphoma Undergoing Dose Escalated BEACOPP Chemotherapy: An Analysis of the German Hodgkin Study Group (GHSG). (2005)

Abstract Introduction: Due to substantial clinical progress over the past decades, the outcome of patients with Hodgkin’s Lymphoma (HL) has improved with a long-term disease free survival of nearly 80%. Even patients with advanced-stage HL show a five year freedom from treatment failure (FFTF) of 87% and overall survival (OS) of 91% when treated with 8 cycles of BEACOPPescalated (bleomycin, etoposide, adriamycin, cyclophosphamide, vincristine, procarbacine, prednisone). However, BEACOPPescalated has been associated with some acute and long-term treatment related mortality (TRM). We thus analysed the incidence, clinical features and risk factors for TRM of patients treated with BEACOPPescalated in the HD12 multicenter trial of the GHSG performed between 1998 and 2002. The HD12 was conducted for advanced HL patients (Stage IIB with large mediastinal mass and/or extranodal involvement, stage III/IV). All patients received 8 cycles of chemotherapy either 8x BEACOPPescalated (Arm A/B) or 4xBEACOPPescalated + 4xBEACOPPbaseline (Arm C/D) +/− 30Gy radiation on bulk and residual tumor. Results: In this study, 43 patients (3.1%) from a total of 1392 included died from TRM. 5 patients were excluded from this analysis because of various reasons (change of fist-line therapy due to toxicity, TRM in BEACOPPbaseline) 38 patients were eligible for this analysis. 30 patients (79%) had infectious complications, 6 (16%) cardiac events such as arrhythmia or heart failure, 1 patient died due to bleomycin-related toxicity and 1 case remained unclear. 25 patients (66%) were older than 50 years in contrast to the whole HD12 study population with only 17% of patients being older than 50. There was no statistical difference between those cases with treatment related mortality and the whole study population in terms of other clinical risk factors such as gender, B-symptoms, extranodal involvement, stage of disease, large mediastinal mass or elevated ESR. There was also no difference between the 4 study arms. Most events occurred during the first 4 courses of BEACOPPescalated (79%) with the majority during the first cycle (n = 12; 32%). 23/26 (89%) of patients who died during cycles 2 – 8 had prior WHO grade III/IV leucopenia or infection. Conclusion: Patient age and toxicity in previous cycles are the most obvious risk factors for TRM in patients with advanced HL undergoing BEACOPPescalated chemotherapy. In the HD12 study, the use of G-CSF was mandatory and most patients received their treatment on an outpatient basis. Thus, possible measures to reduce toxicity with this treatment include the prophylactic use of antibiotics as well as treating those with risk factors at least for the first course as inpatients.
Detectores (2018)

Los detectores de luz pueden describirse como transductores, es decir, proporcionan una señal eléctrica medible como respuesta a la radiación óptica que incide sobre la región sensible. Las tres magnitudes globales de mayor importancia en todos los detectores son: la responsividad, el tiempo de respuesta y la sensibilidad.
Proposed diagnostic criteria for classical chronic myelomonocytic leukemia (CMML), CMML variants and pre-CMML conditions (2019)

Chronic myelomonocytic leukemia (CMML) is a myeloid neoplasm characterized by dysplasia, abnormal production and accumulation of monocytic cells and an elevated risk of transforming into acute leukemia. Over the past two decades, our knowledge about the pathogenesis and molecular mechanisms in CMML has increased substantially. In parallel, better diagnostic criteria and therapeutic strategies have been developed. However, many questions remain regarding prognostication and optimal therapy. In addition, there is a need to define potential pre-phases of CMML and special CMML variants, and to separate these entities from each other and from conditions mimicking CMML. To address these unmet needs, an international consensus group met in a Working Conference in August 2018 and discussed open questions and issues around CMML, its variants, and pre-CMML conditions. The outcomes of this meeting are summarized herein and include diag nostic criteria and a proposed classification of pre-CMML conditions as well as refined minimal diagnostic criteria for classical CMML and special CMML variants, including oligomonocytic CMML and CMML associated with systemic mastocytosis. Moreover, we propose diagnostic standards and tools to distinguish between 'normal', pre-CMML and CMML entities. These criteria and standards should facilitate diagnostic and prognostic evaluations in daily practice and clinical studies in applied hematology.
Effect of recombinant IFN-gamma (rIFN-gamma) on the mechanism of human macrophage IgG FcRI-mediated cytotoxicity. rIFN-gamma decreases inhibition by cytophilic human IgG and changes the cytolytic mechanism (1992)

Abstract Different classes of receptors for the Fc moiety of IgG (Fc gamma R) have been defined on human monocytes and macrophages: Fc gamma RI, Fc gamma RII, and Fc gamma RIII. All three classes are capable of mediating antibody-dependent cell-mediated cytotoxicity (ADCC). Fc gamma RI, which binds monomeric human IgG (hIgG) with high affinity, was shown an effective cytotoxic trigger molecule on different types of cells. In vitro, the inhibition of Fc gamma RI-mediated ADCC by hIgG is well documented. The low affinity receptor classes, Fc gamma RII and Fc gamma RIII, are not blocked by monomeric hIgG. Because monomeric hIgG is present at high concentrations in plasma and interstitial fluids it has been postulated inhibitory in vivo. We investigated the effect of rIFN-gamma on macrophage Fc gamma RI-mediated ADCC in the presence of low doses hIgG. With human E sensitized with hIgG as target cells, Fc gamma RI was studied selectively. We found that rIFN-gamma enhances both expression and cell surface density of Fc gamma RI on cultured peripheral blood monocytes. Furthermore, this cytokine partially reversed the inhibitory effect of monomeric hIgG on ADCC. More interestingly, we found that the cytolytic mechanism of monocyte-derived macrophages changed completely after prolonged culture with rIFN-gamma. Monocytes cultured for 9 days in control medium mediate predominantly phagocytosis. After long term rIFN-gamma stimulation (9 days), monocyte-derived macrophages almost completely lost the capacity to perform phagocytosis. Interestingly, they became highly efficient in mediating extracellular lysis of human E sensitized with hIgG. Short term rIFN-gamma stimulated monocyte-derived macrophages (for the last 40 h of culture) were found to mediate both phagocytosis and extracellular lysis. Our findings suggest that in vivo rIFN-gamma-stimulated macrophages may be most efficient in Fc gamma RI-mediated cytolysis as a consequence of a changed cytolytic mechanism in combination with enhanced Fc gamma RI density.
Data from Mammary-Derived Growth Inhibitor Alters Traffic of EGFR and Induces a Novel Form of Cetuximab Resistance (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Only few predictive factors for the clinical activity of anti–epidermal growth factor receptor (EGFR) therapy are available. Mammary-derived growth inhibitor (MDGI) is a small cytosolic protein suggested to play a role in the differentiation of epithelial cells. Here, we have investigated the effect of MDGI expression on the EGFR signaling and cetuximab responsiveness of cancer cells.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; MDGI mRNA expression was investigated in clinical breast and lung cancer samples and in nontransformed and malignant cell lines. The effect of ectopic expression of MDGI on EGFR, ErbB2, and integrin function and traffic was investigated in breast and lung cancer cell lines using multiple methods. The effect of anti-EGFR agents on these cells were tested by cell proliferation measurements and by assessing tumor growth of breast cancer cells in cetuximab treated and control athymic nude mice.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Here, we show that although MDGI is absent in cultured cell lines because of epigenetic silencing, MDGI mRNA is expressed in 40% of clinical breast carcinomas and 85% of lung cancers. Ectopic expression of MDGI rendered breast and lung cancer cells resistant to the anti-EGFR antibody cetuximab &lt;i&gt;in vitro&lt;/i&gt; and in an orthotopic breast cancer xenograft model &lt;i&gt;in vivo&lt;/i&gt;. When expressed in cancer cells, MDGI induces intracellular accumulation of EGFR, but not ErbB2, and the internalized receptor is phosphorylated and not degraded.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; MDGI-driven inherent desensitization of cancer cells is a novel molecular mechanism for resistance to the anti-EGFR antibody therapy, and MDGI may be a biomarker for responsiveness to anti-EGFR antibody therapy.(Clin Cancer Res 2009;15(21):6570–81)&lt;/p&gt;&lt;/div&gt;
A new stacked NPC converter: 3L-topology and control (2007)

In this paper a new three-level (3L) voltage source converter is presented. This new topology called Stacked Neutral Point Clamped (3L-SNPC) increases the apparent switching frequency compared with other 3L structures (3L-Stacked Cells, 3L-Neutral Point Clamped and 3L-Active NPC). This advantage leads to a better balancing of total losses in power switches under all specified operating conditions (low or high modulation index). The topology has more degrees of freedom and allows a parallel conversion. The load current passes simultaneously or alternatively through two parallel paths, depending on PWM strategy. In the paper three PWM strategies are proposed and their switching states and commutations are analyzed. The total losses in power switches are calculated and compared to the most popular 3L structures. Experimental and simulation results are illustrated in the paper to confirm the operation of the proposed topology.
Protrusion of hepatocellular carcinoma is a predictor of early recurrence in hepatectomy patients after spontaneous rupture (2016)

The results from the present study suggests that spontaneously ruptured HCC patients with protrusion should be frequently monitored after hepatectomy in order to achieve early detection of tumor recurrence and improve survival.
Oral Presentation 12 (2010)

OBJECTIVES: To compare bladder neck and midurethral sling procedures in the treatment of urodynamic stress urinary incontinence (USUI) and low-pressure urethra. MATERIALS AND METHODS: Retropubic midurethral sling procedures have proven efficacy over transobturator sling procedures in the treatment of low-pressure urethra. Bladder neck slings have been considered the gold standard in the treatment of patients with low-pressure urethra. However, there is limited information comparing retropubic midurethral slings to bladder neck slings in the treatment of patients with low-pressure urethra. The aim of this study was to compare the outcomes of bladder neck versus retropubic midurethral sling procedures in the treatment of urodynamic stress urinary incontinence in women with low pressure urethra as defined by maximum urethral closure pressure of ≤20 cm H2O. Subjects with urethral closure pressures ≤20 cm H2O were recruited to undergo either a retropubic or bladder neck sling from 2003 to 2008. After institutional review board approval, 52 subjects were recruited, consented, and randomized. Surgical failure was defined by leakage of urine with cough on urodynamic testing performed at ≥4 months postoperatively; positive standing cough stress test at cystometric volume of 250 cc; 20 minute pad test ≥1 gram; an affirmative response to “Do you experience urine leakage related to coughing, sneezing or laughing?” on the Pelvic Floor Distress Inventory or similar affirmative response on a Likert scale. Statistical methods included Wilcoxon rank sum test, two sample t test, signed rank test, Chi-square test, Fisher's exact test, Crochran-Mantel-Haenszel test, and McNemar's test. Statistical significance reached when P < .05. RESULTS: 41/52 (79%), 20 and 21 patients underwent bladder neck and retropubic midurethral slings, respectively and had 20 and 15 month follow-up data available for comparison. Concomitant prolapse repair was performed as indicated. Preoperative comparisons revealed no difference in age (66.3 ± 11.37 vs. 65.5 ± 18.3), BMI (27.3 ± 4.8 vs. 29.3 ± 5.9), or past history of stress incontinence procedures. Urodynamic testing at ≥4 months in bladder neck 18/20 (90%) and retropubic sling procedures 16/21 (76%) revealed no difference between bladder neck and retropubic sling with respect to cure of USUI 83.3% vs. 100%, P = 0.11, respectively. At 52 weeks 16/20 (80%) bladder neck and 16/21 (76%) retropubic sling subjects demonstrated negative stress urinary incontinence (SUI) as measured on Likert scales 81.2% vs. 87.5%, P = 0.66, respectively. Detrusor overactivity, other urodynamic parameters, post-void residuals, and prolapse stage were similar between groups postoperatively. CONCLUSION: Bladder neck and retropubic midurethral slings had equal efficacy in the cure of: USUI at ≥4 months and SUI at ≥52 weeks postoperatively, in women with low pressure urethra.
Theoretical Study of Twin Polymerization – From Chemical Reactivity to Structure Formation (2012)

Abstract Twin polymerization is a novel technique for synthesizing hybrid polymers with domain sizes in the nanometer range. While a broad variety of monomers have been investigated, the mechanistic details and the most important influences on the nanostructure formation are unknown. A scale bridging approach is presented to simulate the twin polymerization of 2,2'‐spirobi[4H‐1,3,2‐benzodioxasiline]. This approach is based on detailed quantum chemical calculations that yield insight into reactivity and structure at the molecular level while the kinetics of the network formation process and the influences that govern structure formation are investigated at the mesoscopic level by a coarse‐grained simulation. magnified image
Oxygen gradients in the anterior segment of the eye (2007)

Abstract Purpose: To investigate the oxygen gradients in the anterior segment of the eye in anesthetized rabbits. Methods: Mean arterial pressure (MAP) and intraocular pressure (IOP) were measured by direct cannulation of the central ear artery and the vitreous respectively. Laser Doppler flowmetry was used to measure ciliary blood flow (CilBF, n=5), oxygen tension was measured with two fluorescent probes at the corneal endothelium and the anterior surface of the lens. To change oxygen gradients the cornea was exposed to either nitrogen or room air. Results: Baseline values: MAP 75.6±1.3 mmHg, IOP 15±1.5 mmHg, CilBF 53.8±4.2 P.U., oral mucosal oxygen saturation 89.9±0.7 %, pO2 Lens 20.8±3.3 mmHg, pO2 corneal endothelium 49.6±1.5 mmHg. Exposing the cornea to 100% N2 did not change MAP, IOP, CilBF or arterial O2 saturation. However, pO2 at the endothelial side of the cornea and the anterior lens surface dropped by 87% and 57% respectively (p&lt;0.05). Topical brimonidine 0,2% was used to lower CilBF, which caused a significant reduction of oxygen tension in the posterior chamber by 34% and at the corneal endothelium by 8%. Conclusions: Changes of oxygen gradients in response to all perturbations were observed. The cornea is an important source of oxygen in the anterior chamber, however, changing ciliary blood flow also impacts the oxygen levels at the cornea. Oxygen gradients in the anterior segment are very sensitive to local perturbations.
S ahlins, M arshall (2010)

One of the most important figures in American anthropology, Marshall David Sahlins (b. 1930) is known not only for his ethnographic and historical studies of Polynesian societies but also for his vigorous championing and defense of anthropology's culture concept. Born in Chicago, Sahlins received his master's degree from the University of Michigan in 1952. After earning his doctorate in anthropology from Columbia University in 1954, he returned to teach at Michigan. In the 1960s, along with other faculty members, he organized teach‐ins to protest against the war in Vietnam. In 1973, Sahlins moved to the University of Chicago where he is currently the Charles F. Grey Distinguished Service Professor of Anthropology Emeritus.
LFA applicability in SP networks (2012)

Applicability: Pierre Francois was the editor of RFC 6571 [2], LFA applicability in SP networks, co-edited with Clarence Filsfils, distinguished engineer at Cisco Systems. This RFC presents an analysis of the applicability of an IP Fast Reroute technique called Loop-free alternates in Internet Service Provider Networks. This work has been performed in collaboration with Cisco Systems, France Telecom - Orange, AT&T, and Deutsche Telekom.
Biomarkers Provide Clues to Early Events in the Pathogenesis of Breast Implant-Associated Anaplastic Large Cell Lymphoma (2016)

Almost 200 women worldwide have been diagnosed with breast implant-associated anaplastic large cell lymphoma (BIA-ALCL). The unique location and specific lymphoma type strongly suggest an etio-pathologic link between breast implants and BIA-ALCL. It is postulated that chronic inflammation via bacterial infection may be an etiological factor. BIA-ALCL resembles primary cutaneous ALCL (pcALCL) in morphology, activated T-cell phenotype, and indolent clinical course. Gene expression array analysis, flow cytometry, and immunohistochemistry were used to study pcALCL and BIA-ALCL cell lines. Clinical samples were also studied to characterize transcription factor and cytokine profiles of tumor cells and surrounding lymphocytes. BIA-ALCL and pcALCL were found to have common expression of transcription factors SOCS3, JunB, SATB1, and a cytokine profile suggestive of a Th1 phenotype. Similar patterns were observed in a CD30+ cutaneous lymphoproliferative disorder (LPD). The patterns of cytokine and transcription factor expression suggest that BIA-ALCL is likely to arise from chronic bacterial antigen stimulation of T-cells. Further analysis of cytokine and transcription factor profiles may allow early detection and treatment of BIA-ALCL leading to better prognosis and survival. LEVEL OF EVIDENCE 5: Risk.
Flow cytometric analysis of myelodysplasia: Pre‐analytical and technical issues—Recommendations from the European LeukemiaNet (2021)

These recommendations will support and facilitate the appropriate application of FCM assays in the diagnostic workup of MDS patients. Further standardization and harmonization will be required to integrate FCM in MDS diagnostic evaluations in daily practice.