gebhart/patrepeval huggingface dataset:
Correction to Lumbrokinase Attenuates Side-Stream-Smoke-Induced Apoptosis and Autophagy in Young Hamster Hippocampus: Correlated with eNOS Induction and NFκB/iNOS/COX-2 Signaling Suppression (2013)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionCorrection to Lumbrokinase Attenuates Side-Stream-Smoke-Induced Apoptosis and Autophagy in Young Hamster Hippocampus: Correlated with eNOS Induction and NFκB/iNOS/COX-2 Signaling SuppressionChih-Yang Huang, Wei-Wen Kuo, Hung-En Liao, Yueh-Min Lin, Chia-Hua Kuo, Fuu-Jen Tsai, Chang-Hai Tsai, Jia-Long Chen, and Jing-Ying Lin*Cite this: Chem. Res. Toxicol. 2013, 26, 7, 1126Publication Date (Web):June 7, 2013Publication History Published online7 June 2013Published inissue 15 July 2013https://pubs.acs.org/doi/10.1021/tx400193whttps://doi.org/10.1021/tx400193wcorrectionACS PublicationsCopyright © 2013 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views283Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (109 KB) Get e-Alertsclose Get e-Alerts
Influence of nutrition and bovine growth hormone (GH) on hepatic GH binding, insulin-like growth factor-I and growth of lambs (1991)

The effect on young lambs of 0.25 mg recombinant bovine GH (bGH)/kg per day on plasma concentrations of insulin-like growth factor-I (IGF-I), glucose, specific hepatic GH binding and body composition changes was examined at two levels of nutrition (lucerne pellets; 3 and 1.7% of body weight/day). Lambs on low levels of nutrition had low plasma IGF-I (P less than 0.001). Plasma concentrations of IGF-I were increased by bGH treatment at both levels of nutrition, with the high nutrition group showing the greatest IGF-I response after 3 and 40 days of bGH treatment. Plasma glucose, after 40 days, was higher overall (P less than 0.05) in lambs on high nutrition. bGH treatment increased plasma glucose, with the response being greater in the well-fed lambs. Specific binding of GH to liver membranes was highest in lambs on high nutrition and on bGH treatment; no significant interaction between nutrition and bGH treatment was detected, indicating that specific binding of GH was increased proportionally by bGH at both nutritional levels. The major change in body composition was the reduced level of fatness in lambs treated with bGH. There was no significant effect of bGH on body weight although bGH treatment tended to increase weight gain of well-fed lambs and decreased weight loss of poorly nourished lambs. The results show that, although there was a significant (P less than 0.05) bGH/nutrition interaction for IGF-I there was no such interaction for body weight/components or specific GH binding to the liver. The results indicate that an increase in plasma IGF-I does not necessarily result in increases in growth or changes in carcass composition.
Is Choroidal or Scleral Thickness Related to Myopic Macular Degeneration? (2017)

We demonstrated significant thinning of the choroid with increasing MMD severity. In contrast, ST was weakly correlated with MMD. These data suggest progressive loss of choroid may be important in the pathogenesis of MMD.
Article Commentary: Acute Heart Failure: Is it Peripartum Cardiomyopathy or Not? (2013)

Peripartum cardiomyopathy (PPCM) is a potentially life-threatening disease that occurs in women of childbearing age.
ChemInform Abstract: Synthesis of a Novel Prostacyclin Analogue Containing the Bicyclo‐(3.1.0)hexane Ring System. Application of Molecular Mechanics Calculations to Organic Synthesis. (1987)

ChemInformVolume 18, Issue 7 Isocyclic Compounds ChemInform Abstract: Synthesis of a Novel Prostacyclin Analogue Containing the Bicyclo-(3.1.0)hexane Ring System. Application of Molecular Mechanics Calculations to Organic Synthesis. S. W. DJURIC', S. W. DJURIC' Dep. Med. Chem., Searle&Co., Skokie, IL 60077, USASearch for more papers by this authorM. MIYANO, M. MIYANO Dep. Med. Chem., Searle&Co., Skokie, IL 60077, USASearch for more papers by this authorJ. P. SNYDER, J. P. SNYDER Dep. Med. Chem., Searle&Co., Skokie, IL 60077, USASearch for more papers by this author S. W. DJURIC', S. W. DJURIC' Dep. Med. Chem., Searle&Co., Skokie, IL 60077, USASearch for more papers by this authorM. MIYANO, M. MIYANO Dep. Med. Chem., Searle&Co., Skokie, IL 60077, USASearch for more papers by this authorJ. P. SNYDER, J. P. SNYDER Dep. Med. Chem., Searle&Co., Skokie, IL 60077, USASearch for more papers by this author First published: February 17, 1987 https://doi.org/10.1002/chin.198707156Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume18, Issue7February 17, 1987 RelatedInformation
Evaluation of adaptive phased array antenna far field nulling performance in the near field region (1989)

A theory for analyzing the behavior of adaptive phased array antennas illuminated by a near-field interference test source is presented. Conventional phased array near-field focusing is used to produce an equivalent far-field antenna pattern at a range distance of one to two aperture diameters from the adaptive antenna under test. The antenna is assumed to be a linear array of isotropic receive elements. The interferer is assumed to be a bandlimited noise source radiating from an isotropic antenna. The theory is developed for both partially and fully adaptive arrays. Results are presented for the fully adaptive array case with single and multiple interferers. The results indicate that near-field and far-field adaptive nulling can be equivalent. The adaptive nulling characteristics studied in detail are the array radiation patterns, adaptive cancellation, covariance matrix eigenvalues, and adaptive array weights. >
ChemInform Abstract: Aztequynol A, the First Clearly Defined, C‐Branched Polyacetylene and the Analogue Aztequynol B. Isolation from the Tropical Marine Sponge Petrosia sp. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Digital Beamforming as a Means for Interference Cancellation (1997)

The increasing demand for user capacity is a major challenge to network operators today. In order to increase the capacity of a mobile radio network, it is desirable to exploit the spatial domain in an efficient way. An array adds spatial domain selectivity in order to improve the Carrier-to-Interference ratio(C/I). An adaptive antenna array can further improve the Carrier-to-Interference ratio(C/I) by suppressing interfering signals. The proposed circular array consists of K elements and combines fixed beamformers with interference cancellers. The fixed beamformers use a weight matrix to form multiple beams. The interference canceller suppresses undesired signals, called jammers, leaking into the desired beam. The desired signal is filtered out by the fixed beamforming structure. Due to the side-lobes, interfering signals will also be present in this beam. Two alternative strategies may be chosen to cancel these interferers; use the other fixed beam outputs as inputs to an adaptive interference canceller, or regenerate the outputs from the other fixed beams and generate clean signals which are used as inputs to adaptive interference cancellers. Results are presented using beamformer weights obtained from a Least Square (LS) minimisation as well as minimax.
Supplementary Figure S4 from Epigenetic Silencing of miR-490-3p Reactivates the Chromatin Remodeler SMARCD1 to Promote <i>Helicobacter pylori</i>–Induced Gastric Carcinogenesis (2023)

&lt;p&gt;Supplementary Figure S4: Effects of SMARCD1 knockdown and overexpression on oncogenic phenotypes of gastric cancer cells.&lt;/p&gt;
Structural investigation of 2‐naphthyl phenyl ether inhibitors bound to WT and Y181C reverse transcriptase highlights key features of the NNRTI binding site (2020)

Human immunodeficiency virus (HIV)-1 remains as a global health issue that is primarily treated with highly active antiretroviral therapy, a combination of drugs that target the viral life cycle. One class of these drugs are non-nucleoside reverse transcriptase inhibitors (NNRTIs) that target the viral reverse transcriptase (RT). First generation NNRTIs were troubled with poor pharmacological properties and drug resistance, incentivizing the development of improved compounds. One class of developed compounds are the 2-naphthyl phenyl ethers, showing promising efficacy against the Y181C RT mutation. Further biochemical and structural work demonstrated differences in potency against the Y181C mutation and binding mode of the compounds. This work aims to understand the relationship between the binding mode and ability to overcome drug resistance using macromolecular x-ray crystallography. Comparison of 2-naphthyl phenyl ethers bound to Y181C RT reveal that compounds that interact with the invariant W229 are more capable of retaining efficacy against the resistance mutation. Additional modifications to these compounds at the 4-position, computationally designed to compensate for the Y181C mutation, do not demonstrate improved potency. Ultimately, we highlight important considerations for the development of future HIV-1 drugs that are able to combat drug resistance.
Label-free silicon photonic biosensor system with integrated detector array (2009)

An integrated, inexpensive, label-free photonic waveguide biosensor system with multi-analyte capability has been implemented on a silicon photonics integrated circuit from a commercial CMOS line and tested with nanofilms. The local evanescent array coupled (LEAC) biosensor is based on a new physical phenomenon that is fundamentally different from the mechanisms of other evanescent field sensors. Increased local refractive index at the waveguide's upper surface due to the formation of a biological nanofilm causes local modulation of the evanescent field coupled into an array of photodetectors buried under the waveguide. The planar optical waveguide biosensor system exhibits sensitivity of 20%/nm photocurrent modulation in response to adsorbed bovine serum albumin (BSA) layers less than 3 nm thick. In addition to response to BSA, an experiment with patterned photoresist as well as beam propagation method simulations support the evanescent field shift principle. The sensing mechanism enables the integration of all optical and electronic components for a multi-analyte biosensor system on a chip.
Nasal mask continuous positive airway pressure in the treatment of chronic nocturnal cough in a young child (1997)

The objective of this case report was to define the effects of nasal mask continuous positive airway pressure (CPAP) on the respiratory and sleep characteristics of a 3 year-old boy with a 2 year history of snoring and 1 year history of chronic nocturnal cough. The method employed was all-night polysomnography before and during treatment with CPAP after the identification of partial upper airway obstruction in association with cough. The results indicated that the child had evidence of mild upper airways obstruction on initial all-night sleep study. Nasal mask CPAP was instituted. On a subsequent sleep study 4 weeks later, this was documented to prevent the upper airway obstruction at a pressure of 5.2 cm of water. In addition, nasal mask CPAP markedly reduced the nocturnal coughing, the total number of coughs decreasing from 92 to one. The rate of cough per h of study (cough disturbance index) decreased from 9.8-0.1. Sleep efficiency (total sleep time as a percentage of study duration) improved on CPAP from 87 to 99%. This study suggests that chronic nocturnal cough can result from upper airway obstruction in sleep in children and is an important initial observation.
Two-dimensional antiguided vertical cavity surface emitting laser arrays with reflecting boundary (2012)

Antiguided VCSEL arrays are evaluated using an above threshold analysis. Single-mode output power is enhanced by including reflective boundaries at the array edges, and CW single-mode operation of 100mW is predicted from 5×5 2D arrays.
Relaxivity Studies on Dinitroxide and Polynitroxyl Functionalized Dendrimers:  Effect of Electron Exchange and Structure on Paramagnetic Relaxation Enhancement (2003)

The 1H NMR relaxivity of o- and p-dinitroxide-substituted phthalate esters and a series of nitroxyl-functionalized poly(propylene imine) dendrimers has been measured in acetonitrile and methanol. Studies of dinitroxide relaxivity indicate that the electron exchange rate has only a small effect on relaxivity. Outer-sphere relaxivity has been measured using benzene as a probe molecule. In studies on dendritic polynitroxides, the per-nitroxide-based outer-sphere relaxivity nearly doubles for the generation 5 nitroxyl-functionalized dendrimer as compared to a mononitroxide model. This relaxivity enhancement may be due to crowding of dendrimer surface groups in higher generation dendrimers. Water relaxivity has been measured for these polynitroxides as well, and a significant inner-sphere contribution to relaxivity is found. Dendritic polynitroxides exhibit higher per-nitroxide-based water relaxivity as compared to a mononitroxide model. This relaxivity enhancement is attributed to an increase in rotational correlation time (τc) for the dendritic polynitroxides.
Estudio de capacidad mediante simulación: interacción plataforma-calle de rodaje (2017)

Trabajo publicado en Actas del VI Congreso Internacional de la Red Iberoamericana de Investigacion en Transporte Aereo RIDITA 2017.
Development of Field Modulation in a Split-Field Drift Tube for High-Throughput Multidimensional Separations (2005)

A field modulation approach for high-throughput ion mobility/time-of-flight analyses of complex mixtures has been developed using a split-field drift tube. In this approach, complex mixtures of peptides, such as those that arise from tryptic digestion of protein mixtures, are separated by nanocolumn liquid chromatography, ionized by electrospray ionization, and analyzed by ion mobility/time-of-flight techniques. The split-field drift tube allows parent ions to be separated based on differences in their low-field mobilities through the first-field region before entering the second region. For increased throughput, the magnitude of the field in the second region can be modulated throughout an LC separation in order to favor transmission of different types of ions: parent ions at low fields; fragments from primarily [M+3H]3+ peptides at moderate fields; or, fragmentation of [M+3H]3+ and [M+2H]2+ species at higher fields. We demonstrate the approach with two examples: a mixture of tryptic peptides from digestion of hemoglobin; and a complex mixture of tryptic peptides from digestion of human plasma.
EC-CFI: Control-Flow Integrity via Code Encryption Counteracting Fault Attacks (2023)

Fault attacks enable adversaries to manipulate the control-flow of security-critical applications. By inducing targeted faults into the CPU, the software's call graph can be escaped and the control-flow can be redirected to arbitrary functions inside the program. To protect the control-flow from these attacks, dedicated fault control-flow integrity (CFI) countermeasures are commonly deployed. However, these schemes either have high detection latencies or require intrusive hardware changes. In this paper, we present EC-CFI, a software-based cryptographically enforced CFI scheme with no detection latency utilizing hardware features of recent Intel platforms. Our EC-CFI prototype is designed to prevent an adversary from escaping the program's call graph using faults by encrypting each function with a different key before execution. At runtime, the instrumented program dynamically derives the decryption key, ensuring that the code only can be successfully decrypted when the program follows the intended call graph. To enable this level of protection on Intel commodity systems, we introduce extended page table (EPT) aliasing allowing us to achieve function-granular encryption by combing Intel's TME-MK and virtualization technology. We open-source our custom LLVM-based toolchain automatically protecting arbitrary programs with EC-CFI. Furthermore, we evaluate our EPT aliasing approach with the SPEC CPU2017 and Embench-IoT benchmarks and discuss and evaluate potential TME-MK hardware changes minimizing runtime overheads.
Modulation of Integrin Expression on Rat Bone Marrow Cells by Substrates with Different Surface Characteristics (2002)

Biomaterials have been shown to be able to influence the growth and differentiation of osteogenic cells cultured on the surface. Although the precise mechanisms by which the materials influence osteogenic cells are unclear, it is possible that the materials manipulate the expression of integrins by the cells. We therefore studied the expression of a number of integrins by rat bone marrow (RBM) cells, after culture on culture polystyrene, on machined and grit-blasted titanium, and on calcium phosphate-coated titanium. Integrin expression was studied by FACS analysis. We found a large variation in the expression of integrins by cells in replicate experiments. After culture on polystyrene for 7 days, cells expressed alpha1, alpha2, alpha3, alpha5, alpha6, beta1, and beta3, although some of the subunits were expressed only occasionally. The cells did not express the alpha4 subunit. After culture of RBM cells for 8 days on coated and noncoated titanium substrates, cells always expressed alpha3, alpha5, alpha6, and beta1. The alpha1 and beta3 subunits were only expressed in some of the experiments. Frequently, the expression of alpha5, alpha6, and beta1 was higher on the coated than on the noncoated titanium substrates. Based on our results, we conclude that the studied materials are capable of influencing the expression of integrins by RBM cells cultured on relevant implant materials.
MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1 (2009)

Aberrant DNA hypermethylation contributes to myeloid leukemogenesis by silencing structurally normal genes involved in hematopoiesis. MicroRNAs (miRNAs) are noncoding RNAs that regulate gene expression by targeting protein-coding mRNAs. Recently, miRNAs have been shown to play a role as both targets and effectors in gene hypermethylation and silencing in malignant cells. In the current study, we showed that enforced expression of miR-29b in acute myeloid leukemia cells resulted in marked reduction of the expression of DNA methyltransferases DNMT1, DNMT3A, and DNMT3B at both RNA and protein levels. This in turn led to decrease in global DNA methylation and reexpression of p15(INK4b) and ESR1 via promoter DNA hypomethylation. Although down-regulation of DNMT3A and DNMT3B was the result of a direct interaction of miR-29b with the 3' untranslated regions of these genes, no predicted miR-29b interaction sites were found in the DNMT1 3' untranslated regions. Further experiments revealed that miR-29b down-regulates DNMT1 indirectly by targeting Sp1, a transactivator of the DNMT1 gene. Altogether, these data provide novel functional links between miRNAs and aberrant DNA hypermethylation in acute myeloid leukemia and suggest a potentially therapeutic use of synthetic miR-29b oligonucleotides as effective hypomethylating compounds.
Experimental Verification of a Stochastic Topology Approach for High-Power Microwave Effects (2015)

The random coupling model (RCM) and Baum-Liu-Tesche EM topology have been well developed to describe the statistical fluctuation of the scattering and impedance matrices of wave-chaotic metallic-enclosed cavity, and the interaction of interconnected networks of complicated enclosures, respectively. In this paper, a stochastic approach that combines these two methods is tested and verified on a network of wave-chaotic metallic cavities, and induced voltage derived by this method is also compared with other methods.
An LSI hardware design for online character recognition using associative memory (2005)

In this paper, we propose an associative memory based system for real-time character recognition. Based on an associative memory with 128 reference patterns of size 256 bits designed in 0.35 /spl mu/m technology we could get an average nearest-match search time of 130 ns for classification of different samples of characters written in Times and Arial fonts. Comparing to other OCR systems, although this prototype model is not yet robust enough, it is advantageous in terms of classification lime and hardware size.
Strain tuning of the emission axis of quantum emitters in an atomically thin semiconductor (2020)

Strain engineering is a natural route to control the electronic and optical properties of two-dimensional (2D) materials. Recently, 2D semiconductors have also been demonstrated as an intriguing host of strain-induced quantum-confined emitters with unique valley properties inherited from the host semiconductor. Here, we study the continuous and reversible tuning of the light emitted by such localized emitters in a monolayer tungsten diselenide embedded in a van der Waals heterostructure. Biaxial strain is applied on the emitters via strain transfer from a lead magnesium niobate–lead titanate (PMN-PT) piezoelectric substrate. Efficient modulation of the emission energy of several localized emitters up to 10 meV has been demonstrated on application of a voltage on the piezoelectric substrate. Further, we also find that the emission axis rotates by <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"> <mml:mo>∼</mml:mo> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:msup> <mml:mn>40</mml:mn> <mml:mo>∘</mml:mo> </mml:msup> </mml:mrow> </mml:math> as the magnitude of the biaxial strain is varied on these emitters. These results elevate the prospect of using all electrically controlled devices where the property of the localized emitters in a 2D host can be engineered with elastic fields for an integrated opto-electronics and nano-photonics platform.