gebhart/patrepeval huggingface dataset:
Small-angle light scattering to detect strain-directed collagen degradation in native tissue (2011)

It has been demonstrated that there is a mechanochemical relationship between collagen and collagenolytic enzymes such that increased tensile mechanical strain reduces the enzymatic cutting rate. This mechanochemical relationship has the potential to permit directed remodelling of tissue-engineered constructs in vitro and to shed light on the generation of load-adapted collagen-based connective tissue. In this investigation, we demonstrate that small-angle light scattering (SALS) has the sensitivity to dynamically detect the preferential enzymatic degradation of a subset of unloaded collagen fibrils within differentially loaded native tissue. Detection of the difference in the relative degradation rate of unloaded fibrils versus loaded fibrils was manifested through changes in the spatial distribution of the SALS signal. Specifically, we found a linear increase in the eccentricity of the SALS data that was consistent with preferential retention of the collagen fibrils aligned with the applied tensile strain. We conclude that SALS is simple, inexpensive and may provide a useful optical screening method permitting real-time monitoring of strain-controlled tissue and construct remodelling.
The CCR5 receptor acts as an alloantigen in CCR5Δ32 homozygous individuals: Identification of chemokineand HIV-1-blocking human antibodies (1998)

The chemokine receptor CCR5 is the major coreceptor for infection by macrophage-tropic R5 HIV-1. A 32-bp deletion in the gene coding for CCR5 (CCR5Delta32) occurs with a frequency of 10% in the Caucasian population and results in a receptor protein that is truncated and not expressed at the cell surface. CCR5Delta32 homozygous individuals are apparently normal but resistant to infection with R5 HIV-1. In two individuals homozygous for CCR5Delta32, who had been repeatedly exposed to CCR5-expressing blood cells through sexual activity, we have identified antibodies to CCR5 that bound specifically to the surface of CCR5-expressing cell lines. Serum from these individuals, in contrast to serum from CCR5(+/+) individuals, competed with radiolabeled RANTES for binding to the CCR5 receptor and inhibited infection of peripheral blood mononuclear cells with R5, but not X4, primary isolates of HIV-1. The identified human antibodies to CCR5 define an alloantigen that may cause allograft rejection in a mismatch situation even in individuals with no history of blood transfusions or i.v. drug abuse.
GDCI Multi-Cylinder Engine for High Fuel Efficiency and Low Emissions (2015)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;A 1.8L Gasoline Direct Injection Compression Ignition (GDCI) engine was tested over a wide range of engine speeds and loads using RON91 gasoline. The engine was operated with a new partially premixed combustion process without combustion mode switching. Injection parameters were used to control mixture stratification and combustion phasing using a multiple-late injection strategy with GDi-like injection pressures.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;At idle and low loads, rebreathing of hot exhaust gases provided stable compression ignition with very low engine-out NOx and PM emissions. Rebreathing enabled reduced boost pressure, while increasing exhaust temperatures greatly. Hydrocarbon and carbon monoxide emissions after the oxidation catalyst were very low. Brake specific fuel consumption (BSFC) of 267 g/kWh was measured at the 2000 rpm-2bar BMEP global test point.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;At medium load to maximum torque, rebreathing was not used and cooled EGR enabled low-temperature combustion with very low NOx and PM, while meeting combustion noise targets. MAP was reduced to minimize boost parasitics. Minimum BSFC was measured at 213 g/kWh at 1800 rpm - 12 bar IMEP.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;Full load torque characteristics of the engine were developed using alternative injection strategies. Maximum BMEP of 20.3 bar was measured at 2000 rpm, with 17.4 bar BMEP achieved at 1500 rpm. Torque objectives for this engine were met. Transient co-simulations demonstrated the potential for good combustion control during hard accelerations and gear shift transients.&lt;/div&gt;&lt;/div&gt;
Effect of GIP on the secretion of insulin and somatostatin and the accumulation of cyclic AMP in vitro in the rat (1982)

The effects of gastric inhibitory polypeptide (GIP) on insulin secretion as well as on the intra-islet accumulation of [3H]cyclic AMP were investigated in isolated pancreatic islets of the rat. In the presence of 6.7 mmol/l of glucose, 3.0 and 30 nmol/l of GIP induced both insulin and [3H]cyclic AMP responses, while lower and higher concentrations of the peptide were ineffective. A coupling of the two parameters was also found with regard to interaction between glucose and GIP. Thus while 30 nmol/l of GIP was stimulatory together with 6.7, 16.7 or 33.3 mmol/l of glucose, the peptide stimulated neither insulin release, nor the accumulation of [3H]cyclic AMP in the presence of a low concentration of glucose (3.3 mmol/l). The concomittant release of insulin and somatostatin was studied in the perfused pancreas in order to assess a possible influence by somatostatin on the dose-response pattern for GIP-induced insulin release. In this preparation 1.0 to 10 nmol/l of GIP stimulated insulin and somatostatin secretion; however while these concentrations were equipotent on insulin release, 10 nmol/l of GIP stimulated somatostatin release more than 1 nmol/l, indicating differences in dose-response curves for the GIP-induced stimulation of the two hormones. It is concluded that 1) modulation of GIP-induced insulin release is coupled to changes in cyclc AMP response in the islet, 2) GIP-induced somatostatin secretion may influence the concomittant insulin response.
Adaptive graphics (2003)

This article presents the idea of a unifying framework that allows visual representations of information to be customized and mixed together into new ones. The net result is a fine-grained approach to representing data, better suited to accessing and rendering it over networks. Although the focus is on geometric models and 3D shape representations, many issues discussed are relevant to network-based visualization in general.
On the Efficiency of Capacitively Loaded Frequency Reconfigurable Antennas (2013)

The design of a reconfigurable antenna that can be fine tuned to address future communication systems is proposed. The design consists of a capacitively loaded patch antenna for nowadays smartphone platforms. The antenna is narrowband and can be fine tuned over the range (700 MHz–960 MHz). Measurements at 700 MHz with fixed capacitors raise the challenge of the component insertion loss. Distribution of the tuning capacitance is investigated and shows 1 dB improvement in the antenna radiation efficiency.
A distributed routing algorithm for mobile radio networks (2003)

The authors present a distributed routing protocol intended for use in networks where the rate of topological change is not so fast as to make 'flooding' the only possible routing method but not so slow as to make one of the existing protocols for a static topology applicable. The routing algorithm adapts asynchronously in a distributed fashion to arbitrary changes in topology in the absence of global topological knowledge. The protocol maintains a set of loop-free routes to each destination from any node that desires a route. The protocol's performance, measured in terms of end-to-end packet delay and throughput, is compared with that of pure flooding and an alternative algorithm that is well suited to the medium-rate topological change environment envisioned here. The results show that, when the rate of topological change becomes very high, flooding is preferable to the other alternatives. For lower rate of change, it appears that, when the effects of channel access are accounted for, the performance of the new algorithm is encouraging in that it has been generally superior to that of the alternative protocols.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Flow cytometric analysis of glyoxalase‐1 expression in human leukocytes (2011)

Altered glyoxalase-1 (GLO-1) activity and expression is associated with the development of late diabetic complications, malignancy and oxidative stress- and aging-related diseases. In the present study, we developed a flow cytometry method for GLO-1 detection in human leukocytes isolated from peripheral blood samples to investigate GLO-1 expression in leukocyte subsets from type 1 and 2 diabetes mellitus patients (n = 11) and healthy subjects (n = 8). The flow cytometry analysis of GLO-1 in leukocytes showed that expression index of GLO-1-positive cells was slightly increased in mononuclear leukocytes from diabetic patients. This result correlated with the increase in GLO-1 activity in the whole blood samples of type 2 diabetes patients. In conclusion, the present study demonstrates that flow cytometry is suitable for the detection of the GLO-1 enzyme in human leukocytes and that this method could be used to investigate the fast adaptation of the glyoxalase system related to the pathogenesis of late complications of diabetes mellitus and other glycation stress-related disorders.
Issues in multimedia server design (1995)

article Free Access Share on Issues in multimedia server design Authors: Prashant J. Shenoy Univ. of Texas at Austin, Austin Univ. of Texas at Austin, AustinView Profile , Pawan Goyal Univ. of Texas at Austin, Austin Univ. of Texas at Austin, AustinView Profile , Harrick M. Vin Univ. of Texas at Austin, Austin Univ. of Texas at Austin, AustinView Profile Authors Info & Claims ACM Computing SurveysVolume 27Issue 4Dec. 1995 pp 636–639https://doi.org/10.1145/234782.234810Published:01 December 1995Publication History 22citation727DownloadsMetricsTotal Citations22Total Downloads727Last 12 Months24Last 6 weeks10 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
The effect of low and high plasma levels of insulin-like growth factor-1 (IGF-1) on the morphology of major organs: studies of Laron dwarf and bovine growth hormone transgenic (bGHTg) mice. (2013)

It is well known that somatotrophic/insulin signaling affects lifespan in experimental animals. To study the effects of insulin-like growth factor-1 (IGF-1) plasma level on the morphology of major organs, we analyzed lung, heart, liver, kidney, bone marrow, and spleen isolated from 2-year-old growth hormone receptor knockout (GHR-KO) Laron dwarf mice (with low circulating plasma levels of IGF-1) and 6-month-old bovine growth hormone transgenic (bGHTg) mice (with high circulating plasma levels of IGF-1). The ages of the two mutant strains employed in our studies were selected based on their overall ~50% survival (Laron dwarf mice live up to ~4 years and bGHTg mice up to ~1 year). Morphological analysis of the organs of long-living 2-year-old Laron dwarf mice revealed a lower biological age for their organs compared with normal littermates, with more brown adipose tissue (BAT) surrounding the main body organs, lower levels of steatosis in liver, and a lower incidence of leukocyte infiltration in different organs. By contrast, the organs of 6-month-old, short-living bGHTg mice displayed several abnormalities in liver and kidney and a reduced content of BAT around vital organs.
Fiber Optics Receiver Error Rate Prediction Using the Gram-Charlier Series (1980)

This paper applies the Gram-Charlier series method to the caculation of error probabilties in digital optical receivers. This method allows the calculation of "exact" error probabilities including the effects of avalanche noise, thermal noise, and arbitrary posidetection processing filter. The predictions of this method are compared with those of a simple Gaussian approximation and with the Chernoff bounds. Finally, the effects of modal noise are included in the theory, and some specific cases are explored numerically.
25Gb/s Mode Division Multiplexing VCSEL Transmission over Two Modes Using Standard Single-Mode Fiber at 850 nm (2021)

We report 25Gb/s mode division multiplexed single-mode VCSEL transmission over a 1-km standard single-mode fiber, which is two-mode at 850 nm with error free performance using fiber-based mode selective multiplexers.
Studies on Thermogravimetric Properties of Polyphenylene Sulfide and Polyetherether Ketone Resins and Composites (1988)

Polyphenylene sulfide (PPS) and Polyetherether ketone are high performance engineer ing thermoplastics with a unique combination of excellent thermal, mechanical and en vironmental properties. This paper presents the thermogravimetric properties of PPS and PEEK resins and carbon fiber reinforced composites. The addition of carbon fiber and the effects of environment on the thermal stability are presented. Crosslinking of Polypheny lene sulfide in air enhances thermal stability is discussed. PEEK resin and its composite show higher thermal stability than PPS by 70°C to 100°C is also described.
Exact Thermal Design Method for High Output Power Density Converter under Real Circuit Operation Condition (2006)

Exact thermal design for the high output power density (OPD) converter was carried out under real circuit operation conditions, precisely taking the correlation between device power loss characteristics and circuit stray parameters into consideration. Superiority of the proposed power loss design method was confirmed experimentally by using calorimeter. Availability of the proposed method was confirmed by developing the prototype of 3 kW 300 V 3-phase inverter.
Components of the cytoplasmic antigen processing pathway regulates indirect antigen presentation by MHC class II molecules (106.23) (2012)

Abstract Indirect presentation is a process in which MHC class II-positive antigen-presenting cells (APCs) acquire and present antigens expressed by class II-negative allografts, tumours or infected cells. It is generally assumed that similar cellular biochemical mechanisms underlie direct and indirect antigen presentation. This is because in both cases antigens are delivered to the endo/lysosomes for proteolytic processing for assembly of derived peptides with class II molecules and their subsequent display on the cell surface of antigen presenting cells. Remarkably, upon testing this assumption, we found that indirect presentation involved LMP2-dependent immunoproteasomes, indicating that the antigen had accessed the recipient APC’s cytosol. In this cytosol, TAP and ERAAP, but not tapasin, partially destroyed the antigens slated for indirect presentation. Because autophagy was not involved in returning the donated antigen from the cytosol to the endo/lysosome, a novel mechanism(s) is predicted to underlie cytosol to endo/lysosome antigen transport. How components of the cytosolic antigen-processing pathway regulate indirect class II-restricted antigen presentation and the mechanism(s) by which cytosolic antigens are returned to the endo/lysosomes will be presented.
Sol-gel derived β-BBO thin film (1992)

(beta) -BaB<SUB>2</SUB>O<SUB>4</SUB>((beta) -BBO) is known as one of the best inorganic nonlinear crystals. It is now widely used for frequency doubling, frequency mixing in the UV range and optical parametric oscillation in the UV and near infrared regions. To put this material into thin film form would make it very attractive for integrated optical devices. Vacuum deposition techniques are not suitable for the fabrication of borates thin films due to the difficult evaporation or sputtering of oxides based on light elements. The low processing temperature of the sol-gel method allows the formation of stoichiometric and expected oxygen coordination of BaB<SUB>2</SUB>O<SUB>4</SUB> in liquid phase. (beta) -BBO thin films has been successfully prepared by the sol-gel method through hydrolysis of barium and boron alkoxides. The accomplishment of hydrolysis is found to be essential for the removal of residual organic at high temperatures. The choice of precursors, hydrolysis ratio, and thermal treatments have critical influences on the formation, the morphology and the nucleation of (beta) -BBO phase of the film. The undesirable interaction between the film and the substrate limits the formation of (beta) -BBO polycrystalline film to only a few selected substrates.
Molecular cloning of exons II and III of the <FONT FACE=Symbol>a</font>-globin major gene from Odontophrynus americanus 2n and 4n (Amphibia, Anura) (1997)

The &lt;FONT FACE="Symbol"&gt;a&lt;/font&gt;-globin major genes from diploid and tetraploid Odontophrynus americanus were studied using PCR-based technology. The cloned and sequenced amplified fragments were shown to contain most of the exon II sequences as well as the whole exon III sequence of the &lt;FONT FACE="Symbol"&gt;a&lt;/font&gt;-globin gene. Unexpectedly, intron 2 was entirely absent in the amplified fragments of both 2n and 4n origin. High conservation was observed among the obtained sequences when compared to corresponding sequences from human and Xenopus laevis origin. The possibility that these sequences might be pseudogenes is raised
Assessment of bronchodilator responsiveness in preschool children using forced oscillations (2007)

The BD response assessed by the FOT in preschool children should be expressed as a relative change to account for the effect of baseline lung function. The limits for a positive BD response of -40% and 65% for respiratory resistance and reactance, respectively, are recommended.
Comprehensive analysis and comparative evaluation of the isolated true bridgeless Cuk single-phase PFC rectifier system (2013)

In the public low voltage mains the stress caused by harmonic currents is strongly increased due to the higher demand of electronic equipment in everyday use. Therefore, standards were created in order to limit the harmonic currents injected into the network, thus maintaining a high voltage quality of these networks. Hence, converter systems with active PFC are indispensable, where in general the compliance of the created directives for lower harmonics can be easily fulfilled. Typically, in single-phase systems, boost PFC converter topologies are used, which offer a wide input voltage range and a controlled output voltage. Depending on the underlying applications, a subsequent reduction and/or isolation of the output voltage based on a DC/DC-converter is needed. The major disadvantages of this converter cascading are the reduction of the overall efficiency, the large component count and the increasing control complexity. In comparison to the conventional two-stage PFC converter system, the true bridgeless Cuk PFC rectifier system can perform the PFC functionality and the galvanic isolation in a single-stage, thus eliminating the mentioned disadvantages. In this paper a comprehensive analysis of the operation, design and limits of the recently proposed single-stage Cuk concept is investigated. In addition, a comparative evaluation concerning efficiency and power density against a conventional two-stage approach based on bridgeless PFC rectifier and a subsequent LLC-resonant DC/DC-converter is presented.
Silicon on Sapphire Chip Based Mid-Infrared Optical Spectroscopy for Detection of Chemical Warfare Simulant Triethyl phosphate (2014)

Triethyl phosphate (TEP), a chemical warfare simulant, has absorption peaks in the mid-infrared. Using a single mode slot wave guide we were able to detect TEP, with a detection limit down to 75 ppm. This provides enhanced sensitivity while simultaneously achieving device miniaturization.
Data from Characterization of Bone Metastases from Rapid Autopsies of Prostate Cancer Patients (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Bone is the most common metastatic site for prostate cancer, and osseous metastases are the leading cause of morbidity from this disease. Recent autopsy studies prove that 100% of men who die of prostate cancer have bone involvement. Understanding the biology of prostate cancer and its evolution to an incurable androgen-independent phenotype requires an understanding of the genetic and cellular alterations that lead to the seeding and proliferation of tumor foci in bone, as well as the microenvironment in which these metastases arise. No intensive studies, however, have been conducted on osseous metastatic tissues from patients with metastatic prostate cancer due to lack of access to such tissues for profiling and other research.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; We show, for the first time, a reproducible methodology to obtain high quality clinical tumor tissues metastatic to the bone. This technique allowed the procurement of viable metastatic tumor tissue from involved bones in 13 recent autopsies conducted at the University of Michigan and analyzed the gene expression of these tissues using real-time PCR and microarrays.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; We present here the discovery of nonossified bone metastases from multiple patients with advanced prostate cancer and their subsequent characterization and comparison to nonosseous metastases from the same patients.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusion:&lt;/b&gt; This represents a versatile and practical approach that may be employed to characterize the steps in metastasis and the phenotypic characteristics of osseous metastasis of prostate cancer and to profile RNA, DNA, and cDNA from tumor samples metastatic to the bone. &lt;i&gt;Clin Cancer Res; 17(12); 3924–32. ©2011 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Dual Cross-Linking Systems of Functionally Photo-Cross-Linkable and Thermoresponsive Polyphosphazene Hydrogels for Biomedical Applications (2010)

Photo-cross-linkable, functionalized, and thermosensitive polyphosphazenes were synthesized to develop a dual cross-linking system with properties of mechanically suitable strength and controllable biodegradation for injectable biomedical applications. The aqueous solutions of the polymers exhibited sol-gel transition behaviors against temperature. The incorporated methacrylate groups were photo-cross-linked upon UV light under mild conditions, which resulted in the formation of compact three-dimensional networks. The thermoresponsive hydrophobic interactions at body temperature facilitated the rapid dual cross-linking accomplishment of the photo-cross-linking even under mild conditions. The characteristics of the polymers such as pore size and density showed that the inner three-dimensional networks depended on the degree of cross-linking of methacrylate units. Mechanical properties of the gel were also improved several folds after developing the photo-cross-linking in the network from the in vivo degradation studies. The results demonstrate that the photo-cross-linkable and thermoresponsive polyphosphazenes have great potential as injectable, biodegradable, and controllable carriers for various biomedical applications by tuning the mechanical gel property and the degradation rate.
Hypervalent Sulfur Fluorides and the Design of Liquid Crystals (2014)

Hypervalent sulfur fluorides are providing functional materials - such as liquid crystals - with unique physicochemical properties and new geometric structural elements.