gebhart/patrepeval huggingface dataset:
An assessment of duplexing methods for the radio links of personal communication systems (2003)

Personal communications is a new area of mobile communications, and many trials are taking place to test different technologies. The paper addresses a fundamental consideration in the planning and designing of radio links for personal communications: duplexing. It provides an assessment of the relative strengths and weaknesses of frequency division duplexing and time division duplexing as they apply to spectrum considerations, radio design considerations, and radio implementation considerations. The analysis shows that frequency division duplexing is the preferred technique if spectrum is available; if small pieces of spectrum are allocated, time division duplexing is required.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Nanoscale Scanning Probe Thermometry (2018)

We present further development and application examples of a thermometry approach capable of producing real-space temperature maps of operating nanoscale devices with sub-10nm resolution. The technique relies on scanning thermal microscopy with a resistive element coupled to a cantilevered tip. The resistive element acts both as integrated heater and as sensing element. A modulated temperature field is generated in the sample by exciting the device under investigation with an electrical AC bias. A map of the sample's temperature response due to different physical effects, such as Joule heating and thermoelectric effects, can be inferred from the demodulated sensor signal. As application examples, we demonstrate the investigation of thermoelectric heating/cooling at crystal phase heterostructures in InAs nanowires and Joule self-heating of individual multi-walled carbon nanotubes.
Quantum Teleportation with a Quantum Dot Single Photon Source (2004)

We report the experimental demonstration of a quantum teleportation protocol with a semiconductor single photon source. Two qubits, a target and an ancilla, each defined by a single photon occupying two optical modes (dual-rail qubit), were generated independently by the single photon source. Upon measurement of two modes from different qubits and postselection, the state of the two remaining modes was found to reproduce the state of the target qubit. In particular, the coherence between the target qubit modes was transferred to the output modes to a large extent. The observed fidelity is 80%, in agreement with the residual distinguishability between consecutive photons from the source. An improved version of this teleportation scheme using more ancillas is the building block of the recent Knill, Laflamme, and Milburn proposal for efficient linear optics quantum computation.
Construction of Chimeric Phages and Plasmids Containing the Origin of Replication of Bacteriophage Lambda (1977)

Segments of the replication control region of bacteriophage lambda (λ) and λ mutants defective in replication were attached in vitro to the φ80 phage vector Charon 3 and to the plasmid vector mini Col El (pVH51). The chimeric phages and plasmids have been used to localize the origin of λ DNA replication and to facilitate a structural analysis of the λ replicator.
Optical Stethoscopy: Imaging With λ/20 (1986)

Unprecedented optical image resolution has been obtained using a near-field optical scanner called &quot;optical stethoscope&quot;: 20 to 30 nm with blue light of half a micron wavelength! Key element is an extremely small aperture (5-10 nm) placed at the very top of a sharply pointed pyramidal or conical screen. The aperture is scanned in the immediate proximity of the surface to be investigated. The amount of light transmitted by both aperture and sample depends sensitively on the optical properties of the sample in the immediate vicinity of the aperture.
A New Efficient Synthesis of 5‐Aryloxazoles (III) from Arylidene Diacetates and Application to the Preparation of BMS‐337197 (VII), a Novel IMPDH Inhibitor. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
SnipMatch (2012)

Programmers routinely use source code snippets to increase their productivity. However, locating and adapting code snippets to the current context still takes time: for example, variables must be renamed, and dependencies included. We believe that when programmers decide to invest time in creating a new code snippet from scratch, they would also be willing to spend additional effort to make that code snippet configurable and easy to integrate. To explore this insight, we built SnipMatch, a plug-in for the Eclipse IDE. SnipMatch introduces a simple markup that allows snippet authors to specify search patterns and integration instructions. SnipMatch leverages this information, in conjunction with current code context, to improve snippet search and parameterization. For example, when a search query includes local variables, SnipMatch suggests compatible snippets, and automatically adapts them by substituting in these variables. In the lab, we observed that participants integrated snippets faster when using SnipMatch than when using standard Eclipse. Findings from a public deployment to 93 programmers suggest that SnipMatch has become integrated into the work practices of real users.
A reservation limited sensing protocol in wireless networks (2002)

Random access algorithms are suitable for large numbers of users generating light, bursty, single packet traffic. However, when users generate packet "sequences" with high probability, reservation mechanisms may be employed to increase channel throughput. Hybrid access schemes containing both contention and reservation components have been previously introduced and analyzed. In this paper, we introduce hybrid schemes based on a limited-sensing random access algorithm and investigate their throughput under the heavy traffic assumption. Two protocols are implemented, differing by whether or not the number of packets per message is fixed or variable. Their performance is examined in a multicell setting, in the presence of feedback errors which arise from intercell interference when the cells' coverage areas partially overlap.
Invited review: Fine (2–5‐nm) filaments: New types of cytoskeletal structures (1987)

Over the past 30 years filaments 2-5 nm in diameter have been found in a number of different types of eukaryotic cells. As a group, these fine filaments lack the similarity of composition and function that characterize the three major classes of cytoskeletal elements--microfilaments, microtubules, and intermediate filaments. Six different proteins that form fine filaments have been identified; proposed functions for these fibers range from cell motility to cytoarchitecture. Recent studies, however, have revealed filaments with similar compositions and/or functions in otherwise different cells, suggesting that the fine filaments may eventually fit into a limited number of subgroups.
Pain after Percutaneous Nephrolithotomy: Impact of Nephrostomy Tube Size (2003)

The use of a small drainage catheter after PCNL is associated with lower pain scores in the immediate postoperative period, yet no statistically significant benefit to the patient with regard to comfort is demonstrated beyond 6 hours. In addition, there is a trend toward reduced narcotic requirements. Finally, there is no apparent increase in patient morbidity from the use of the smaller nephrostomy tubes.
The present status of endoluminal stented grafts for the treatment of aneurysms, traumatic injuries and arterial occlusions (1996)

The purpose of this study was to report the updated results of a prospective, multicenter, nonrandomized, single-arm investigational device exemption study conducted at 17 sites in the United States to assess safety and effectiveness of the Zenith Alpha thoracic endovascular graft (Cook Medical, Bloomington, Ind) for treatment of blunt thoracic aortic injury (BTAI).The primary safety end point was 30-day all-cause mortality and aortic injury-related mortality. The primary effectiveness end point was 30-day device success. Additional outcomes evaluated included major adverse events and imaging findings including aortic injury healing, graft patency, and device integrity as analyzed by the core laboratory on follow-up computed tomography imaging through 5 years.A total of 50 patients with BTAI were enrolled in the TRANSFIX study between January 2013 and May 2014. Mean follow-up was 21 months (range, 0.6-35 months). The 30-day mortality was 2% (n = 1), and it was unrelated to the aortic repair or study device. Five deaths occurred after 30 days, and one was considered procedure related. Freedom from all-cause and BTAI-related mortality was 89.3% and 97.6%, respectively, at 2 years. Aortic injury healing was noted in 96% at 2 years. An incidental finding of thrombus formation within the stent graft, most commonly at the distal aspect of the study device, occurred in 15 patients (30%; 12 by core laboratory, 3 by site) and was confirmed in 13 patients (26%). None of these patients were noted to have clinical sequelae on most recent follow-up.The updated results from the TRANSFIX study continue to show low rates of aortic injury-related mortality and major adverse events during follow-up. However, findings of in-graft thrombus have resulted in the manufacturer's voluntary removal of the BTAI indication for this device. Caution should be exercised in appropriate and accurate device sizing and planning (eg, limiting graft oversizing) as well as in regular, lifelong follow-up evaluation.
NCHRP REPORT 350 COMPLIANCE TEST 5-12 OF THE 1.07-M VERTICAL WALL BRIDGE RAILING (1997)

The Federal Highway Administration (FHWA) recently adopted new performance evaluation guidelines for roadside safety features set forth in NCHRP Report 350. Most of the existing roadside features were tested according to the previous guidelines contained in NCHRP Report 230 and there are concerns as to how the existing roadside safety features would perform under the new guidelines. Specifically, there is concern that existing bridge railing systems, including the 1.07-m vertical wall bridge railing, may not perform satisfactorily to contain and redirect the 36000V test vehicle, i.e., 36,000-kg tractor/van trailer, and the vehicle may roll over. In a previous study conducted by the Texas Transportation Institute, a 22,680-kg tractor/van trailer steered around the end of a 1.07-m vertical wall bridge railing and rolled onto its side. In orter to determine if a longer installation would prevent this from happening, the bridge railing was extended from 30 m to a total length of 40 m. There were also questions about the strength of the bridge railing and the strength of its connection to the deck. This report contains the results of a crash test performed on the 1.07-m vertical wall bridge railing with a 36000V test vehicle under NCHRP Report 350 test level 5 conditions, i.e., impacting the length of need at a nominal speed and angle of 80 km/h and 15 degrees. The purpose of the test was to determine if the bridge railing would perform satisfactorily in containing and redirecting the heavy vehicle without rolling the vehicle. The impact performance of the 1.07-m vertical wall bridge railing was considered satisfactory according to evaluation criteria set forth in NCHRP Report 350 for test designation 5-12. The 36000V vehicle did not roll after exiting the longer installation as the 22,680-kg tractor/van trailer did on the 30-m installation used during an earlier study. There was no sign of structural damage in the bridge railing or in the connection of the bridge railing and bridge deck.
Cross-Linked Hyperbranched Arylamine Polymers as Hole-Transporting Materials for Polymer LEDs (2006)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTCross-Linked Hyperbranched Arylamine Polymers as Hole-Transporting Materials for Polymer LEDsGeeta Kheter Paul, Jeremiah Mwaura, Avni A. Argun, Prasad Taranekar, and John R. ReynoldsView Author Information The George and Josephine Butler Polymer Laboratories, Department of Chemistry and Center for Macromolecular Science and Engineering, University of Florida, Gainesville, Florida 32611 Cite this: Macromolecules 2006, 39, 23, 7789–7792Publication Date (Web):October 20, 2006Publication History Received10 April 2006Revised12 September 2006Published online20 October 2006Published inissue 1 November 2006https://pubs.acs.org/doi/10.1021/ma060808phttps://doi.org/10.1021/ma060808prapid-communicationACS PublicationsCopyright © 2006 American Chemical SocietyRequest reuse permissionsArticle Views1913Altmetric-Citations83LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Layers,Nucleic acid structure,Polymer films,Polymer solutions,Polymers Get e-Alerts
Uncertain role of endothelium-derived relaxing factor in mesenteric arterioles of cats and rabbits. (1988)

Experiments were undertaken in the mesentery of anesthetized cats and rabbits to investigate whether the endothelium of resistance vessels mediates relaxation of arteriolar smooth muscle through the endothelium-derived relaxing factor(s) (EDRF). The microcirculation was visualized by transillumination using intravital microscopy and a Millikan camera. Pictures were obtained at a rate of 400 frames/second. Arteriolar mean diameter and surface area were computer calculated. The animals were divided in two groups. In one group of experiments, EDRF was inactivated by direct injection of hydroquinone (HQ) into the superior mesenteric artery and the second group served as control. Norepinephrine or vasopressin constricted while acetylcholine or Ca-ionophore A23187 dilated arterioles. Hydroquinone failed to inhibit arteriolar dilation in situ. The effect of HQ on the endothelium in situ was ascertained by bioassay of superior mesenteric artery strips. Our results cast doubt on the role of EDRF in the dilation of mesenteric arterioles in felines and rabbits.
Estimation of contrast agent concentration using spectrum analysis (1998)

A theoretical scattering model was formulated to calculate the calibrated power spectrum of ultrasound contrast agents. The analysis incorporates the scattering coefficient from an encapsulated contrast agent bubble and includes the effects of realistic focused beams. The results relate specific spectral features to the characteristics of contrast agents, including their concentration and size distribution. Analytical calculations and experimental studies were conducted to analyze the calibrated power spectra of backscatter data using Albunex® and AerosomesTM over frequency bands employed in typical medical ultrasound (3–12 MHz) and very-high-frequency ultrasound (VHFU, 15–50 MHz). The results showed that contrast agent concentration can be estimated from the spectral features such as the spectral slope and intercept values, which are measured using linear regression analysis. These studies also demonstrated the feasibility of employing contrast agent with VHFU, using wide-band transducers with center frequencies near 40 MHz. The VHFU scans of in vivo rabbit eyes showed the time history of contrast agent activity and revealed increased backscatter (as much as 8 dB) within subsegments of the ciliary body. Estimation of contrast agent concentration as a function of time promises to provide key information about perfusion in a contrast agent perfused organ.
Abstract PR010: First-in-class TRPV6 inhibitors for the treatment of prostate cancer (2023)

Abstract TRPV6, a calcium channel, is an oncochannel that is overexpressed in epithelial cancers including prostate cancer. We have developed a novel series of first-in-class small molecule TRPV6 inhibitors for the treatment of advanced prostate cancer. Our preclinical candidate QED-203 has been shown to inhibit calcium influx at low nM potency in TRPV6 cellular assays (FLIPR, electrophysiology), and has low nM potency in a TRPV6-driven NFAT assay (NFAT luciferase reporter). Inhibition of TRPV6 with our TRPV6 inhibitors or by siRNA knockdown causes changes in genes related to NFAT and WNT signalling, ER stress and the cell cycle (RNAseq and qPCR analysis), and causes cell cycle arrest, decreased proliferation and apoptosis in prostate cancer cells (demonstrated via imaging and FACS analysis). Importantly, QED-203 demonstrates potency in enzalutamide resistant cell lines (in vitro proliferation inhibition) and has superior potency over enzalutamide and darolutamide [androgen receptor targeting agents (ARTA)] in prostate cancer cell lines with clinically relevant AR mutations or the ARV7 splice variant. The ARV7 variant in particular is represented in a significant portion of patients no longer responding to ARTA SoC interventions. QED-203 has high bioavailability with a pharmacokinetic profile amenable to once-a-day oral dosing. QED-203 is well tolerated in rodents and has similar in vivo efficacy (tumour growth and PSA inhibition) to enzalutamide in a castrated LNCaP mouse model of prostate cancer. We have also shown QED-203 target engagement in rodents by demonstrating a change in calcium levels in the urine, and have observed changes in genes consistent with a TRPV6-specific mode of action in xenograft tumours (demonstrated via qPCR). QED-203 targets a novel, non-hormonal mechanism in prostate cancer, and could be used to treat prostate cancer patients who have developed resistance to AR therapies, where there is a large unmet need. Citation Format: Kimberley Beaumont, Rebecca Pouwer, Raphael Rahmani, Matthew McLachlan, Claire Levrier, Rebecca Farrow, Mei Yeh, Therese Johnson, Malika Kumarasiri, Hasanthi Wijesekera, Grant Stuchbury, Terrie-Anne Cock, Andrew Harvey, Gregory Monteith, Brian Dymock. First-in-class TRPV6 inhibitors for the treatment of prostate cancer [abstract]. In: Proceedings of the AACR Special Conference: Advances in Prostate Cancer Research; 2023 Mar 15-18; Denver, Colorado. Philadelphia (PA): AACR; Cancer Res 2023;83(11 Suppl):Abstract nr PR010.
Regulation of Human Bone Marrow Leucopoiesis (1974)

S ummary . The clonal growth of bone marrow in soft‐gel culture is largely dependent on the presence of colony‐stimulating factors (CSF). However, when human marrow is cultured in liquid medium with the in vitro diffusion chamber technique, proliferation and differentiation of granulocytes and mononuclear cells proceeds without a requirement for exogenously supplied CSF. The addition of highly active monocyte‐conditioned medium to the liquid marrow cultures did not result in a measurable change in viable or differential cell counts. Similarly, when mono‐cytes were co‐cultivated with bone marrow in a double‐chamber apparatus, no stimulation of marrow cell growth was observed. Colony‐stimulating activity was identified in conditioned medium derived from the liquid marrow cultures, and the cultured marrow cells themselves stimulated colony formation when incorporated as feeder layers. Retention of marrow cell responsiveness to CSF in liquid culture was demonstrated by cloning the cultured marrow cells in agar at intervals up to 2 weeks. Evidence was obtained that bone marrow cells of the monocyte‐macrophage line were primarily responsible for the elaboration of CSF in liquid culture. These data suggest a role for humoral interactions between haematopoietic cells within the marrow cavity.
Pyroelectric properties of La-Modified PbTiO3thin films and their applications (1997)

Abstract Highly c-axis oriented La-modified PbTiO3(Pb1-xLaxTi1-x/4O3;PLT) thin films were successfully grown on MgO single crystal substrates by rf-magnetron sputtering method. The PLT thin films display the phenomenon named “self-polarization” and have high figures of merit for pyroelectric infrared(IR) sensor without a poling treatment. It was found that this self-polarization depends on the substrate temperature and is based on a fairly small difference of the thin film composition:Pb/Ti. High performance IR sensors were fabricated by using the PLT (x=0.1, γ=5.5 × 10-8 C/cm2K, εr=180) thin films and a new 3-dimensional structure. The sensors have remarkably high D* of 3.5 × 108cmHz1/2/W and very fast response
[Analysis of chondrocyte differentiation using chondrocyte-specific genetically modified mice]. (2011)

Knockout mice are used to study physiological function of the gene, while transgenic mice expressing a high level of the transgene are used to examine pharmacological action of the gene. Genes can be deleted not only in chondrocytes, but also at various steps during the process of chondrocyte differentiation in conditional knockout mice. Conditional transgenic mouse system is available in cases in which conventional transgenic mouse lines cannot be established due to early lethality. It is possible that Cre-mediated recombination occurs at loxP sites in osteoblasts of chondrocyte-specific conditional knockout mice, suggesting that bone phenotype should be carefully analyzed and discussed.
Supplementary Methods from Resistance to CDK2 Inhibitors Is Associated with Selection of Polyploid Cells in <i>CCNE1</i>-Amplified Ovarian Cancer (2023)

&lt;p&gt;Supplementary Methods - PDF file 70K, CDK2 sequencing methods and primer sequences&lt;/p&gt;
Zinc inhibits lethal inflammatory shock by preventing microbe‐induced interferon signature in intestinal epithelium (2020)

The cytokine TNF drives inflammatory diseases, e.g., Crohn's disease. In a mouse model of TNF-induced systemic inflammatory response syndrome (SIRS), severe impact on intestinal epithelial cells (IECs) is observed. Zinc confers complete protection in this model. We found that zinc no longer protects in animals which lack glucocorticoids (GCs), or express mutant versions of their receptor GR in IECs, nor in mice which lack gut microbiota. RNA-seq studies in IECs showed that zinc caused reduction in expression of constitutive (STAT1-induced) interferon-stimulated response (ISRE) genes and interferon regulatory factor (IRF) genes. Since some of these genes are involved in TNF-induced cell death in intestinal crypt Paneth cells, and since zinc has direct effects on the composition of the gut microbiota (such as several Staphylococcus species) and on TNF-induced Paneth cell death, we postulate a new zinc-related anti-inflammatory mechanism. Zinc modulates the gut microbiota, causing less induction of ISRE/IRF genes in crypt cells, less TNF-induced necroptosis in Paneth cells, and less fatal evasion of gut bacteria into the system.