gebhart/patrepeval huggingface dataset:
Privacy Extensions for DNS-SD (2018)

DNS-SD (DNS Service Discovery) normally discloses information about
both the devices offering services and the devices requesting
services. This information includes host names, network parameters,
and possibly a further description of the corresponding service
instance. Especially when mobile devices engage in DNS Service
Discovery over Multicast DNS at a public hotspot, a serious privacy
problem arises. We propose to solve this problem by a two-stage
approach. In the first stage, hosts discover Private Discovery Service
Instances via DNS-SD using special formats to protect their privacy.
These service instances correspond to Private Discovery Servers
running on peers. In the second stage, hosts directly query these
Private Discovery Servers via DNS-SD over TLS. A pairwise shared
secret necessary to establish these connections is only known to hosts
authorized by a pairing system. Revisions of this draft are currently
considered in the DNSSD working group.
Estimation of Illuminants for Plausible Lighting in Augmented Reality (2011)

This paper presents a practical method to estimate the positions of light sources in real environment, using a mirror sphere placed on a known natural marker. For the stable results of static lighting, we take the multiple images around a sphere and estimate the principal light directions of the vector clusters for each light source in running-time. We also estimate the moving illuminant for changes of the scene illumination, and augment the virtual objects onto the real image with the proper shading and shadows. Some experimental results show that the proposed method produces plausible AR visualization in real time.
Resistance degradation of CVD (Ba,Sr)TiO/sub 3/ thin films for DRAMs and integrated decoupling capacitors (2002)

We have investigated the important failure mechanism of resistance degradation for polycrystalline MOCVD (Ba,Sr)TiO/sub 3/ thin films appropriate for use in DRAMs, as a function of voltage (field), thickness and temperature. At constant field, the measured degradation lifetime decreases with increasing film thickness, resulting from a decrease in the activation energy with respect to temperature for thicker films. Similarly, there are clear indications that thicker films are more field sensitive. Predicted resistance degradation lifetimes obtained from both temperature and voltage extrapolations for DRAM operating conditions of 85/spl deg/C and 1.6 V exceed the current benchmark of 10 years for all the films studied.
Imaging of Polymeric Nanoparticles: Hard Challenge for Soft Objects (2016)

With the emergence of nanotechnology and nanoscience in the past two decades a thorough characterization at the nanoscale became more and more important. The characterization of nanoparticles is the main issue for the understanding of their properties. Besides averaging methods like scattering techniques the direct imaging of nanoparticles by microscopy methods is the major characterization method. Especially electron microscopy proved to be a valuable tool to obtain morphological and analytical information. The aim of this article is to point out the prospects as well as the pitfalls of this technique with special emphasis on the electron microscopical imaging of polymeric nanoparticles. We will present two alternative methods to cryo-TEM preparation: embedding the sample into an ultrathin film of trehalose as already used for the preparation for biological samples and the preparation of an ultrathin, free standing ionic liquid film as embedding matrix for nanoparticular structures.
Synthesis of 2′,3′‐Modified Carbocyclic L‐Nucleoside Analogues (2011)

Abstract New divergent approaches to 2′,3′‐modified carbocyclic L ‐nucleoside analogues starting from enantiomerically pure (1 R ,2 S )‐ or (1 S ,2 R )‐2‐(benzyloxymethyl)cyclopent‐3‐enol are described. In the key step, stereochemically pure cyclopentanols were condensed with N 3‐protected thymine through a modified Mitsunobu protocol. Moreover, several routes to different cyclopentanol derivatives, to prepare carbocyclic L ‐2′,3′‐didehydro‐2′,3′‐dideoxynucleosides ( L ‐d4N), L ‐2′,3′‐dideoxynucleosides ( L ‐ddN), and L ‐ribonucleosides are reported.
Homogeneous Precipitation of Dy2O3 Nanoparticles—Effects of Synthesis Parameters (2007)

The experimental parameters that control the size and size distribution of dysprosium oxide nanoparticles synthesized by homogeneous precipitation technique have been systematically investigated. The particles were characterized with respect to their size, shape, and thermal decomposition behavior. It was found that the precipitated particles were spherical, uniform in size, and amorphous, which upon heating in air, decomposed into the oxide form with no change in morphology. The size and size distribution of the particles showed strong dependence on the metal cation concentration ([Dy3+]) and weak dependence on urea concentration and aging time. In addition, the presence of chlorine ions (Cl-) was found to have significant effect on the growth and agglomeration of the particles. Aggregation mechanism as the growth mechanism is offered to explain the effects of these synthesis parameters on the morphology, size, and size distribution of dysprosium oxide particles.
Lebertransplantation bei M. Wilson: Erfahrungen unseres Zentrums (2006)

Einleitung: Der Morbus Wilson ist eine erbliche Störung des Kupfermetabolismus und führt in fortgeschrittenem Stadium zu Leberzirrhose und neurologischen Störungen. Bei Versagen der medikamentösen Therapie ist die Lebertransplantation eine wesentliche Therapieoption, wobei wichtige Langzeitbeobachtungen von großen Kollektiven nach Transplantation noch ausstehen.
Accuracy of the Enlite 6-Day Glucose Sensor with Guardian and Veo Calibration Algorithms (2011)

The Enlite sensor accurately measures glucose when compared with gold standard laboratory measurements over its 6-day use. Sensors placed in the buttocks region exhibited greater time lags than sensors placed in the abdomen.
Investigation of the initial dip in fMRI at 7 Tesla (2001)

Abstract In agreement with optical imaging studies, previous fMRI studies have reported an initial decrease (i.e. the initial dip) in the BOLD response, which is believed to arise from an increase in oxygen consumption and to be mostly microvascular. To date, experimental studies of the initial dip in humans have been performed at fields up to 4 T, with relatively low spatial resolution. Because the sensitivity to microvascular contribution is increased at high magnetic fields, the present study investigated the initial dip at 7 T. In addition, to reduce the partial volume effect, the study is conducted at a high spatial resolution. The initial dip was detected in all subjects studied and was found to reside mostly in the gray matter. The relative amplitude of the early response was found to be 0.6, higher than that at 4 T (0.3) and 1.5 T (0.11). In addition, based on the assumption that the initial dip is a result of increased oxygen utilization, the fractional change in oxygen utilization was estimated to be 40% of that of the fractional change in cerebral blood flow. These results are in agreement with the notion that the initial dip arises from an increase in oxygen consumption. Copyright © 2001 John Wiley &amp; Sons, Ltd. Abbreviations used: CBF cerebral blood flow CMRO 2 cerebral metabolic rate of oxygen OVS outer volume suppression PVE partial volume effect
Plant immune and growth receptors share common signalling components but localise to distinct plasma membrane nanodomains (2017)

Cell surface receptors govern a multitude of signalling pathways in multicellular organisms. In plants, prominent examples are the receptor kinases FLS2 and BRI1, which activate immunity and steroid-mediated growth, respectively. Intriguingly, despite inducing distinct signalling outputs, both receptors employ common downstream signalling components, which exist in plasma membrane (PM)-localised protein complexes. An important question is thus how these receptor complexes maintain signalling specificity. Live-cell imaging revealed that FLS2 and BRI1 form PM nanoclusters. Using single-particle tracking we could discriminate both cluster populations and we observed spatiotemporal separation between immune and growth signalling platforms. This finding was confirmed by visualising FLS2 and BRI1 within distinct PM nanodomains marked by specific remorin proteins and differential co-localisation with the cytoskeleton. Our results thus suggest that signalling specificity between these pathways may be explained by the spatial separation of FLS2 and BRI1 with their associated signalling components within dedicated PM nanodomains.
The Authors' Reply (1991)

The Authors' Reply Get access Ralph H. Hruban, M.D., Ralph H. Hruban, M.D. Memorial Sloan-Kettering Cancer Center New York, New York Search for other works by this author on: Oxford Academic Google Scholar Andrew G. Huvos, M.D., Andrew G. Huvos, M.D. Memorial Sloan-Kettering Cancer Center New York, New York Search for other works by this author on: Oxford Academic Google Scholar Frank Traganos, Ph.D., Frank Traganos, Ph.D. Memorial Sloan-Kettering Cancer Center New York, New York Search for other works by this author on: Oxford Academic Google Scholar Victor Reuter, M.D., Victor Reuter, M.D. Memorial Sloan-Kettering Cancer Center New York, New York Search for other works by this author on: Oxford Academic Google Scholar Philip H. Lieberman, M.D., Philip H. Lieberman, M.D. Memorial Sloan-Kettering Cancer Center New York, New York Search for other works by this author on: Oxford Academic Google Scholar Myron R. Melamed, M.D. Myron R. Melamed, M.D. Memorial Sloan-Kettering Cancer Center New York, New York Search for other works by this author on: Oxford Academic Google Scholar American Journal of Clinical Pathology, Volume 95, Issue 5, 1 May 1991, Page 579, https://doi.org/10.1093/ajcp/95.5.759 Published: 01 May 1991
Abstract 23: Microrna302-367 Sphingosine 1 Phosphate Receptor 1 Pathway Prevents Tumor Growth via Restricting Angiogenesis and Enhancing Vascular Stability (2016)

Angiogenic hypersprouting and leaky immature vessels of pathological angiogenesis are essential for tumor growth. MicroRNAs have unique therapeutic advantages by targeting multiple pathways of tumor-associated angiogenesis, but the function of individual miRNAs in angiogenesis and tumors has not yet been fully evaluated. Here, we show that miR302-367 elevation in endothelial cells reduces retina sprouting angiogenesis and promotes vascular stability in vivo, ex vivo and in vitro. Erk1/2 are identified as direct targets of miR302-367, and down-regulation of Erk1/2 upon miR302-367 elevation in endothelial cells increases the expression of Klf2 and in turn S1pr1 and its downstream target VE-cadherin, suppressing angiogenesis and improving vascular stability. Conversely, both pharmacological blockade and genetic deletion of S1pr1 in endothelial cells reverse the anti-angiogenic and vascular stabilizing effect of miR302-367 in mice. Pathological angiogenesis in tumors shares features of developmental angiogenesis, and endothelial specific elevation of miR302-367 reduces tumor growth by restricting sprout angiogenesis and decreasing vascular permeability via the same Erk1/2-Klf2-S1pr1 pathways. In conclusion, miR302-367 regulation of an Erk1/2-Klf2-S1pr1 pathway in the endothelium advances our understanding of angiogenesis, meanwhile also provides opportunities for therapeutic intervention of tumor growth.
High-resolution crystals of human hematopoietic and lipocalin-type prostaglandin D synthases in space (2008)

Human thioredoxin1 (hTRX1) is a small 12-kD oxidoreductase enzyme consisting of 105 amino acids and containing a dithiol/ disulfide active site with multiple cellular functions. This enzyme has activity as a cellular reductase by a dithiol-disulfide exchange reaction using two cysteine residues (Cys32 and Cys35) in the conserved active site sequence. Apart from the two cysteines, there are three additional conserved cysteines, Cys62, Cys69, and Cys73 in the mammalian TRX, which have not been known to their biological functions. Although it has been identified that the Cys73 residue is involved in dimerization of hTRX via an intermolecular disulfide bond formation between Cys73 of each monomer in the oxidized state, biological function of the Cys62 and Cys69 residues in the nonactive remain to be fully elucidated. In the previous paper, researchers proposed that the formation of a disulfide bond between Cys62 and Cys69 could give a way to transiently inhibit hTRX activity for redox signaling or oxidative stress. Furthermore, they proposed a model structure of the non-active site disulfide in the hTRX. Here, we present the high-resolution crystal structure of fully oxidized hTRX1, which shows an intramolecular disulfide bond between Cys62 and Cys69. The disulfide bond formation disengages a helix proximal to the active site and results in a conformational change of the hTRX enzyme, providing a structural basis for understanding the regulation mechanism of redox signaling or oxidative stress.
Proteins in the insulin‐secreting cell line MIN6 bind the imidazoline compound BL11282 (2008)

The imidazoline BL11282 stimulates insulin release and alters islet proteomes. Subcellular fractions of MIN6 cells showed that the membrane fraction exhibited binding to BL11282 on a Biacore chip and to BL11282‐labelled magnetic beads. Bound material extracted from the beads showed a ∼50 kDa differential band upon SDS–PAGE and a weaker 100 kDa band. The former was sensitive to competitive removal by preincubation of the fraction with BL11282, then highlighting the ∼100 kDa band. Masspectrometric analysis revealed the ∼50 kDa band to be EF1A and the ∼100 kDa band to be glucose regulated P94, both of interest in insulin synthesis and secretion.
Re-examinatin on the Imna Related Phrase in the Stele for Seon Master Jingyeong ; the Identities of Imna(任那), Chobal(草拔), and Geumgwan-state(金官國) (2021)

김유신의 후손인 진경대사의 행적을 기록한 <봉림사진경대사비> 중에서 대사의 가계를 이야기하고 있는 ‘其先任那王族草拔聖枝’의 구절은 임나(任那)의 성격에 관한 1차적 기록으로 중시되어 왔다. 기존에는 김유신이 금관국 왕족 출신이라는 점을 근거로 위의 기록이 ‘임나=금관국=김해가야’임을 보여주는 근거로 활용되었지만, 이 구절에서 ‘초발(草拔)’의 의미가 무엇인지는 제대로 밝혀지지 않았다. 이 구절은 ‘其先, 任那王族·草拔聖枝’의 대구(對句) 형식이므로 임나(任那)와 초발(草拔)은 서로 밀접하게 관련된 존재로서, 임나의 시조나 시조가 속한 집단으로 보아야 할 것이다. 실제로 초발(草拔)의 동음이의어인 초발(初發)은 임나, 즉 금관국의 시조는 수로(首露)와 동일한 의미를 갖는다. 이로 볼 때 초발(草拔)은 본래 임나의 시조 혹은 시조가 속한 집단이었고, 이것이 좋은 의미의 한자로 바뀌는 과정에서 초발(初發)→수로(首露)로 변화된 것으로 추정된다. 한편 『일본서기』의 금관국과 남가라(南加羅), 즉 원래의 가야국의 멸망에 관한 기록을 살펴볼 때 금관국(=임나)과 김해에 있던 남가라(南加羅)는 본래 별개의 정치세력이었는데, 금관국(=임나)이 신라에 병합되고 그 주민들이 김해 지역에 옮겨 살면서 금관국(=임나)과 남가라가 동일한 정치세력으로 오해되었던 것으로 보인다. 금관국(=임나)은 본래 초발(草拔)과 발음이 비슷한 초팔혜(草八兮)로서 합천 동부의 쌍책면·초계면 지역에 위치하였으며, 이곳에 있는 옥전고분군 및 성산리토성 등은 금관국과 관련된 유적으로 추정된다. 이 금관국은 북쪽의 고령 지역 정치세력과 함께 대가야(大伽倻)를 구성하는 중심 세력이었으며, 이는 대가야와 금관국의 시조가 형제로서 가야산신의 아들이라는 전설과도 상통한다.
Comparison of at-wavelenth inspection, printability, and simulation of nanometer-scale substrate defects in extreme ultraviolet lithography (EUVL) (1999)

We report on the comparison of defect printability experimental results with at-wavelength defect inspection and printability modeling at extreme ultraviolet (EUV) wavelengths. Two sets of EUV masks were fabricated with nm- scale substrate defect topographies patterned using a sacrificial layer and dry-etch process, while the absorber pattern was defined using a subtractive metal process. One set of masks employed a silicon dioxide film to produce the programmed defects, whereas the other set used chromium films. Line-, proximity- and point-defects were patterned and had lateral dimensions in the range of 0.2 micrometer X 0.2 micrometer to 8.0 micrometer X 1.5 micrometer on the EUV reticle, and a topography in the range of 8 nm - 45 nm. Substrate defect topographies were measured by atomic force microscopy (AFM) before and after deposition of EUV-reflective Mo/Si multilayers. The programmed defect masks were then characterized using an actinic inspection tool. All EUVL printing experiments were performed using Sandia's 10x- reduction EUV Microstepper, which has a projection optics system with a wavefront error less than 1 nm, and a numerical aperture of 0.088. Defect dimensions and exposure conditions were entered into a defect printability model. In this investigation, we compare the simulation predictions with experimental results.
Human genetic deficiencies reveal the roles of complement in the inflammatory network: Lessons from nature (2009)

Complement component C5 is crucial for experimental animal inflammatory tissue damage; however, its involvement in human inflammation is incompletely understood. The responses to gram-negative bacteria were here studied taking advantage of human genetic complement-deficiencies--nature's own knockouts--including a previously undescribed C5 defect. Such deficiencies provide a unique tool for investigating the biological role of proteins. The experimental conditions allowed cross-talk between the different inflammatory pathways using a whole blood model based on the anticoagulant lepirudin, which does not interfere with the complement system. Expression of tissue factor, cell adhesion molecules, and oxidative burst depended highly on C5, mediated through the activation product C5a, whereas granulocyte enzyme release relied mainly on C3 and was C5a-independent. Release of cytokines and chemokines was mediated to varying degrees by complement and CD14; for example, interleukin (IL)-1beta and IL-8 were more dependent on complement than IFN-gamma and IL-6, which were highly dependent on CD14. IL-1 receptor antagonist (IL-1ra) and IFN-gamma inducible protein 10 (IP-10) were fully dependent on CD14 and inversely regulated by complement, that is, complement deficiency and complement inhibition enhanced their release. Granulocyte responses were mainly complement-dependent, whereas monocyte responses were more dependent on CD14. Notably, all responses were abolished by combined neutralization of complement and CD14. The present study provides important insight into the comprehensive role of complement in human inflammatory responses to gram-negative bacteria.
Fluorescence-based tracing of transplanted intestinal epithelial cells using confocal laser endomicroscopy (2019)

It is highly feasible to use fluorescent dye-based labeling in combination with CLE to trace intestinal organoids following transplantation to confirm implantation at the intestinal target site.
TYPE I AND TYPE II SENSITIZERS BASED ON ROSE BENGAL ONIUM SALTS* (1988)

Abstract— New Rose Bengal oniurn salts containing one or two iodonium, sulfonium, phosphonium, and pyrylium ions have been prepared as part of a program to develop sensitizers which can function as Type I radical photoinitiators and Type II energy transfer donors depending on experimental conditions. The absorption spectra of the onium salts in different solvents indicate an equilibrium between tight and loose ion pairs which depends on the solvent polarity, the cation and concentration. Typical Rose Bengal photochemistry requires the structure be that of the loose ion pair in the solvent of choice. Similar factors also influence bleaching behavior, and bleaching is the result of electron transfer processes. The quantum yields of singlet oxygen production from the onium salts in polar solvents are similar to that of the parent, Rose Bengal disodium salt.
Optimal strategies for identifying kidney disease in diabetes: properties of screening tests, progression of renal dysfunction and impact of treatment – systematic review and modelling of progression and cost-effectiveness (2014)

The National Institute for Health Research Health Technology Assessment programme.
Network Coding for Dynamically Changing Networks (2008)

We here advocate the case for network coding as a guiding paradigm for the operation of networks that vary in a small time frame, due to node mobility, channel variations, and varying traffic conditions. Three ideas that appeared succesively in time brought in place an elegant operation for network coding in such environments. These are, use of randomized network coding for intermediate node operation, use of generations to avoid synchronization, and use of subspace coding to allow for small packet sizes. Information theoretical performance limits support these results.
Enantioselective Synthesis of Allylsilanes Bearing Tertiary and Quaternary Si‐Substituted Carbons Through Cu‐Catalyzed Allylic Alkylations with Alkylzinc and Arylzinc Reagents. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Supplementary Figure 4 from Vitamin E Analogues Inhibit Angiogenesis by Selective Induction of Apoptosis in Proliferating Endothelial Cells: The Role of Oxidative Stress (2023)

Supplementary Figure 4 from Vitamin E Analogues Inhibit Angiogenesis by Selective Induction of Apoptosis in Proliferating Endothelial Cells: The Role of Oxidative Stress
Hydrodynamic modeling of leachate recirculating landfills (1999)

Leachate recirculation is an emerging technology for theon-site management of leachate. The benefits of leachate recirculation have been well-documented by a variety of researchers. However, little work has been done to address the hydrodynamic behavior of the landfill, i.e. the effect of recirculation system and waste characteristics on leachate routing. A modified form of SUTRA – a United States Geological Survey (USGS) saturated–unsaturated flow and transport model – was used to simulate the forces driving liquid movement through a landfill. The variables evaluated included leachate input rates, the permeability of intermediate cover materials, waste permeability, and waste heterogeneity. The model was verified using data from operating landfills in Delaware, California, New York, and Florida.
Joint Uplink Scheduling and Interference Mitigation in Multicell LTE Networks (2011)

Uplink resource allocation with intercell interference mitigation in LTE networks is investigated. A non-cooperative probabilistic interference avoidance scheme and a pricing-based cooperative power control scheme are proposed. A scheduling algorithm is presented and used with the proposed interference mitigation schemes. In the absence of power control, scheduling with the probabilistic interference avoidance scheme is shown to lead to considerable enhancements over classical reuse schemes. When cooperative power control is added, the proposed approach is shown to outperform the standard LTE power control approach.
Setting 6G Architecture in Motion - the Hexa-X Approach (2022)

The most recent cellular generation, 5G, is being deployed on a large scale globally. The capabilities of 5G surpass all previous generations of cellular networks and support many new services compared to 4G. Despite this, at the same time, preparations for 6G have begun since user demands and technical development continuously push the boundaries of what is possible. Demands come not only from users. Also, society sets requirements, e.g., sustainability, coverage, and privacy. To support the necessary features in the network needed to meet the requirements, a new generation of the architecture is needed; one based on the most forward-looking design principles together with trends in networks, use cases, and whatnot. To show that the proposed new features will allow the future network to meet the set requirements, key performance indicators (KPIs) have to be defined. In this paper, we present six of the KPIs that the European 6G flagship project Hexa-X has identified as the fundamental ones to measure the most important aspects of a new 6G architecture.