gebhart/patrepeval huggingface dataset:
Supplementary Table S2 from The Master Neural Transcription Factor BRN2 Is an Androgen Receptor–Suppressed Driver of Neuroendocrine Differentiation in Prostate Cancer (2023)

&lt;p&gt;NEPC signature for GSEA analysis.&lt;/p&gt;
Improvement of Light Trapping in a-Si:H-Based Solar Cells by Inserting a ZnO/LiF Double Interlayer (2014)

We develop a zinc oxide (ZnO)/lithium fluoride (LiF) double interlayer for effective light trapping in p-i-n-type hydrogenated amorphous silicon (a-Si:H)-based solar cells with a 200-nm-thick intrinsic a-Si:H absorber. The spectral response of the fabricated solar cell with an n-type a-Si:H (n-a-Si:H)/ZnO/LiF/aluminum back structure was significantly enhanced in the wide wavelength range of 500-750 nm because of the refractive index grading, reduced plasmonic absorption, and efficient tunneling of photogenerated electrons through the ultrathin LiF interlayer, resulting in the significant enhancement of the short-circuit current by 21.6%. Consequently, the conversion efficiency is improved by 13.3%.
CCR2 Antagonists for the Treatment of Diseases Associated with Inflammation (2012)

The CCR2 and MCP-1 pathway has become one of the most-studied chemokine systems for therapeutic use in inflammatory diseases and conditions. It plays a pivotal role in inflammatory diseases, especially those that are characterized by monocyte-rich infiltration. This chapter reviews the biology of CCR2 and MCP-1, and their roles in diseases and conditions related to inflammation such as rheumatoid arthritis, multiple sclerosis, asthma, obesity, type 2 diabetes, atherosclerosis, nephropathy, cancer, pulmonary fibrosis and pain. Intense drug-discovery efforts over the past 15 years have generated a large number of CCR2 antagonists in diverse structural classes. Mutagenesis studies have elucidated important residues on CCR2 that interact with many classes of these CCR2 antagonists. To facilitate understanding of CCR2 antagonist SAR, a simple pharmacophore model is used to summarize the large number of diverse chemical structures. The majority of published compounds are classified based on their central core structures using this model. Key SAR points in the published literature are briefly discussed for most of the series. Lead compounds in each chemical series are highlighted where information is available. The challenges in drug discovery and development of CCR2 antagonists are briefly discussed. Clinical candidates in various diseases in the public domain are summarized with a brief discussion about the clinical challenges.
A missense mutation in the neurofibromatosis 2 gene occurs in patients with mild and severe phenotypes (1996)

We identified a missense mutation (T185-->C, Phe62-->Ser) in the neurofibromatosis 2 (NF2) gene in a family with mild and severe NF2 phenotypes. This mutation was previously reported in an unrelated family in which all affected individuals had mild phenotypes. These data demonstrate a lack of correlation between NF2 genotype and NF2 phenotype for this mutation.
On the Anomalous Broadening of the Positronium Peak in NaF: Possibility of Metastable Self-Trapped Positronium State (1980)

Recently observed anomalous temperature dependence of the width of the positronium peak in NaF is interpreted in terms of metastably self-trapped positronium. Analysis of the data indicates that there exists metastable self-trapped state of positronium at about 0.1 eV above the ground state of free positronium.
Escherichia coli 4.5S RNA gene function can be complemented by heterologous bacterial RNA genes (1990)

The essential 4.5S RNA gene of Escherichia coli can be complemented by 4.5S RNA-like genes from three other eubacteria, including both gram-positive and gram-negative organisms. Two of the genes encode RNAs similar in size to the E. coli species; the third, from Bacillus subtilis, specifies an RNA more than twice as large. The heterologous genes are expressed efficiently in E. coli, and the product RNAs resemble those produced by cognate cells. We conclude that the heterologous RNAs can replace E. coli 4.5S RNA and that the essential function of 4.5S RNA is evolutionarily conserved. A consensus structure is presented for the functionally related 4.5S RNA homologs.
Automated lookahead data migration in SSD-enabled multi-tiered storage systems (2010)

The significant IO improvements of Solid State Disks (SSD) over traditional rotational hard disks makes it an attractive approach to integrate SSDs in tiered storage systems for performance enhancement. However, to integrate SSD into multi-tiered storage system effectively, automated data migration between SSD and HDD plays a critical role. In many real world application scenarios like banking and supermarket environments, workload and IO profile present interesting characteristics and also bear the constraint of workload deadline. How to fully release the power of data migration while guaranteeing the migration deadline is critical to maximizing the performance of SSD-enabled multi-tiered storage system. In this paper, we present an automated, deadline-aware, lookahead migration scheme to address the data migration challenge. We analyze the factors that may impact on the performance of lookahead migration efficiency and develop a greedy algorithm to adaptively determine the optimal lookahead window size to optimize the effectiveness of lookahead migration, aiming at improving overall system performance and resource utilization while meeting workload deadlines. We compare our lookahead migration approach with the basic migration model and validate the effectiveness and efficiency of our adaptive lookahead migration approach through a trace driven experimental study.
Identifying Active Phage Lysins through Functional Viral Metagenomics (2010)

Recent metagenomic sequencing studies of uncultured viral populations have provided novel insights into the ecology of environmental bacteriophage. At the same time, viral metagenomes could also represent a potential source of recombinant proteins with biotechnological value. In order to identify such proteins, a novel two-step screening technique was devised for cloning phage lytic enzymes from uncultured viral DNA. This plasmid-based approach first involves a primary screen in which transformed Escherichia coli clones that demonstrate colony lysis following exposure to inducing agent are identified. This effect, which can be due to the expression of membrane-permeabilizing phage holins, is discerned by the development a hemolytic effect in surrounding blood agar. In a secondary step, the clones identified in the primary screen are overlaid with autoclaved Gram-negative bacteria (specifically Pseudomonas aeruginosa) to assay directly for recombinant expression of lytic enzymes, which are often encoded proximally to holins in phage genomes. As proof-of-principle, the method was applied to a viral metagenomic library constructed from mixed animal feces, and 26 actively expressed lytic enzymes were cloned. These proteins include both Gram-positive-like and Gram-negative-like enzymes, as well as several atypical lysins whose predicted structures are less common among known phage. Overall, this study represents one of the first functional screens of a viral metagenomic population, and it provides a general approach for characterizing lysins from uncultured phage.
3D Tissue-Engineered Bone Marrow: What does this Mean for the Treatment of Multiple Myeloma? (2016)

3DTEBM • bone marrow • drug
Coherence Model for Building Layover in Interferometric SAR. (2016)

Abstract not provided.
Intermolecular excimer kinetics of methyl pyrenebutyrate in polystyrene/toluene mixtures (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIntermolecular excimer kinetics of methyl pyrenebutyrate in polystyrene/toluene mixturesJ. M. G. Martinho, M. Tencer, M. Campos, and M. A. WinnikCite this: Macromolecules 1989, 22, 1, 322–327Publication Date (Print):January 1, 1989Publication History Published online1 May 2002Published inissue 1 January 1989https://pubs.acs.org/doi/10.1021/ma00191a058https://doi.org/10.1021/ma00191a058research-articleACS PublicationsRequest reuse permissionsArticle Views57Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Transistors: From Crystals to Integrated Circuits (1996)

This new book by M. Levinshtein and G. Simin tells the readers about the design and work of the most important and interesting semiconductor devices - the transistors. The book is written in a friendly and easy to read manner and is meant primarily for young people, high school students, freshmen and sophomores. However, the original approach to semiconductor physics makes this book attractive to physics teachers and professors as well. The book consists of 3 parts: Part I: the section on semiconductors describes the main properties of semiconductors, explains the difference between the semiconductors, metals and dielectrics. We find here the explanation of the appearance of the properties of semiconductors which underlie their numerous applications. This part also contains a vivid and detailed description of the main types of motion of the charge carriers in semiconductors: thermal motion, motion in the electric field and diffusion. Part II covers barriers and junctions. In order to understand the principles of the work of the most important semiconductor devices, it is not sufficient just to get to know the properties of semiconductors. It is also quite essential to study certain specific and interesting phenomena - the so-called junctions. This part of the book contains a detailed and vivid description of those properties and in that view of the properties of the p-n junctions and diodes: photodiodes, varicaps, light emitting diodes, solar cells and rectifier diodes. Part III covers transistors. It describes the basis of the work of the bipolar and field effect transistors. Without making use of rather complicated equations or notions of quantum mechanics the authors give a clear and simple explanation of the cause of ability of those devices to amplify and generate electric signals. They tell the readers how transistors are manufactured and describe the work of the transistor's simplest circuits. The last chapter of the book is devoted to the ideas underlying the transistors: integrated circuits. It is these integrated circuits which are the foundation of modern electronics: from telephone apparatus to supercomputers, from medical instruments to cosmic communication systems. In conclusion, the authors make an attempt to foresee and imagine, together with the reader what other devices may come to substitute the transistor in the future.
Magnesium Storage Performance and Mechanism of 2D‐Ultrathin Nanosheet‐Assembled Spinel MgIn2S4 Cathode for High‐Temperature Mg Batteries (2019)

Magnesium batteries have the potential to be a next generation battery with large capability and high safety, owing to the high abundance, great volumetric energy density, and reversible dendrite-free capability of Mg anodes. However, the lack of a stable high-voltage electrolyte, and the sluggish Mg-ion diffusion in lattices and through interfaces limit the practical uses of Mg batteries. Herein, a spinel MgIn<sub>2</sub> S<sub>4</sub> microflower-like material assembled by 2D-ultrathin (≈5.0 nm) nanosheets is reported and first used as a cathode material for high-temperature Mg batteries with an ionic liquid electrolyte. The nonflammable ionic liquid electrolyte ensure the safety under high temperatures. As prepared MgIn<sub>2</sub> S<sub>4</sub> exhibits wide-temperature-range adaptability (50-150 °C), ultrahigh capacity (≈500 mAh g<sup>-1</sup> under 1.2 V vs Mg/Mg<sup>2+</sup> ), fast Mg<sup>2+</sup> diffusibility (≈2.0 × 10<sup>-8</sup> cm<sup>2</sup> s<sup>-1</sup> ), and excellent cyclability (without capacity decay after 450 cycles). These excellent electrochemical properties are due to the fast kinetics of magnesium by the 2D nanosheets spinel structure and safe high-temperature operation environment. From ex situ X-ray diffraction and transmission electron microscopy measurements, a conversion reaction of the Mg<sup>2+</sup> storage mechanism is found. The excellent performance and superior security make it promising in high-temperature batteries for practical applications.
Agent Based Approaches to Engineering Autonomous Space Software (2010)

Current approaches to the engineering of space software such as satellite control systems are based around the development of feedback controllers using packages such as MatLab's Simulink toolbox. These provide powerful tools for engineering real time systems that adapt to changes in the environment but are limited when the controller itself needs to be adapted. We are investigating ways in which ideas from temporal logics and agent programming can be integrated with the use of such control systems to provide a more powerful layer of autonomous decision making. This paper will discuss our initial approaches to the engineering of such systems.
J0320405 Tensile and Shear Deformation Properties of Porous Aluminum (2014)

Porous aluminum sandwiches with the aluminum foam and dense steel sheets were fabricated by the friction stir processing (FSP) route. Using the fabricated sandwiches, failure tests were carried out under combined loading of tensile type and shear type. Under only shear type loading, two types of failure (i.e., tensile type failure and shear type failure) were observed. Under combined loading, tensile type failure firstly occurred, then shear type deformation markedly increased. The tensile strength and shear strength of porous aluminum could be approximately defined by the maximum principal stress and maximum shear stress, respectively.
Modular Metallic Radial Head Replacement (2010)

The presentation of radial head fractures ranges from simple undisplaced fractures to complex injuries associated with elbow and wrist instability. Although the majority of fractures can be managed nonoperatively or with open reduction and internal fixation, prosthetic replacement of the radial head is indicated for displaced comminuted fractures that are not reconstructable. Radial head arthroplasty is also used for malunions, nonunions, posttraumatic arthritis, and instability. Accurate implant sizing and attention to associated osseous and soft tissue injuries is the key to a successful result. The medium term outcome of metallic radial head arthroplasty is encouraging; however, long-term follow-up studies are needed.
Increased alkaline phosphatase isoforms in autoimmune diseases (1997)

We found significant increases in ALP and ALP isoform band 10 in the serum of patients with early insulin-dependent diabetes, rheumatoid arthritis, and in those with multiple sclerosis during periods of disease exacerbation as compared with healthy controls. The ALP isoforms were assayed by isoelectric focusing. Our data suggest that the increase in ALP and ALP-10 closely reflects the abnormal activation of T lymphocytes that is common in autoimmune diseases, and that the source of the ALP-10 is activated T lymphocytes. ALP-10 is a sensitive but nonspecific marker of an active autoimmune process and appears to have the ability to detect abnormal T-cell activation. ALP-10 may be a useful test in the screening for autoimmune disorders.
Cultivation of the photosynthesis microorganism in a Taylor-Couette Vortex Flow with a small aspect ratio (2009)

This study focuses on the dynamics of the Taylor-Couette Vortex Flow (TVF) in a photo-bioreactor in which CO2 is changed to O2 with high efficiency by the photosynthesis ability of micro algae. Stirring by means of a screw propeller is generally used for a simple agitation. However, the problem is that there exists a very high shearing flow region just near the propeller, which causes the destruction of the alga cell by the shearing force. In contrast, the TVF mixing is expected to reduce such a local and random shearing force because of their column of steady and orderly vortices. In this study, the relationship between the microorganism growth rate and the flow structures in dilute suspensions of a TVF is investigated and the flow characteristics are measured by using an ultrasonic velocity profiler with a small aspect ratio of 3.
Outgassing Characteristics of Low-Molecular-Weight Resists for Extreme Ultraviolet Lithography (2005)

We discuss the outgassing characteristics under extreme ultraviolet (EUV) exposure for a new resist system based on amorphous low-molecular-weight (Mw) polyphenols consisting of 4,4'-methylenebis[2-[di(2-methyl-4-hydroxy-5-cyclohexylphenyl)]methyl] phenol (3M6C-MBSA) compared with polyhydroxystyrene. (PHOST) The outgassing characteristics of the photoresist based on the PHOST resin were better than those of the photoresist based on 3M6C-MBSA as the base material. However, when the same polymer was reacted with a protecting group, the outgassing characteristics were reversed. The decomposition reaction mechanism under EUV exposure is discussed on the basis of results from both mass spectrometry and FT-IR measurements. The results indicate that the reactions of 3M6C-MBSA (Resist B) and PHOST (Resist D) under EUV exposure have different mechanisms. It was confirmed that the decomposition of the molecular backbone is the main reaction for 3M6C-MBSA, whereas the decomposition of the protective group is the main reaction for PHOST.
Voltage stabilizers for improving the electrical treeing resistance of XLPE (2008)

Voltage stabilizers have only been used as an electrical tree retardant in commercial polyolefin high voltage cables to a very small extent. A reason for this could be their lack of solubility and in many cases limited efficiency. The low solubility has led to migration of the voltage stabilizers from the bulk of the material to evaporate on the surface. However, in this article it will be shown that it is possible to incorporate small amounts of voltage stabilizers to increase the resistance to electrical treeing of polyethylene significant and that the stabilizers added to the polymeric matrix will not migrate in any large extent. These properties are crucial to ensure the long term properties of the insulation system. The efficiency of the best new voltage stabilizer presented in this paper will exceed the ones previously published significantly.
Using Biomimetic Scaffold Platform to Detect Growth Factor Induced Changes in Migration Dynamics of Nasopharyngeal Epithelial Cells (2020)

A polydimethylsiloxane two-layer scaffold platform was designed to provide a three-dimensional biomimetic microsystem that allows the detection of epithelial-to-mesenchymal transition without the use of specific biomarkers. As a proof of concept, a novel microsystem that consisted of two layers of 15 μm thick grating structures was developed. These layers had gratings with 40 μm wide ridges and 10 μm wide trenches, and they were stacked together to form a scaffold platform. To investigate the feasibility of using the engineered platforms for detecting changes in epithelial-to-mesenchymal transition, transforming growth factor beta-1 was added to an untransformed nasopharyngeal epithelial cell line. On flat polydimethylsiloxane surfaces, transforming growth factor beta-1 did not significantly affect nasopharyngeal epithelial size, migration speed, or directionality. However, the effect of transforming growth factor beta-1 treatment on migration speed of nasopharyngeal epithelial cells cultured on the two-layer scaffold platform was significantly different. Furthermore, while almost no untreated nasopharyngeal epithelial cells could squeeze into the 10 μm wide trenches, 21% of the transforming growth factor beta-1 treated nasopharyngeal epithelial cells exhibited traversing behaviors on the two-layer scaffold platforms. Moreover, fibronectin coating on the trenches and bottom layers of the scaffold platforms further enhanced the transforming growth factor beta-1-induced traversing of nasopharyngeal epithelial cells into the narrow trenches. These results demonstrate that the engineered two-layer scaffold microsystem can be used to monitor epithelial-tomesenchymal transition induced changes in cell migration and invasiveness, paving the way of using these platforms in high throughput drug screening.
0.6 pm Pitch Highly Reliable Multilevel Interconnection Using rogen Silicate Inorganic SOG for Sub-Quarter Micron CMOS Technology (1997)

A 0.6 p pitch highly reliable multilevel interconnection technology using low-k Hydrogen Silicate Based Inorganic Spinon Glass (HSI-!SOG) is demonstrated for 0.15 p CMOS devices. A stable HSI-SOG interlayer dielectric (ILD) with low leakage current is realized in the metallization process with above 400 “c. The reliability of wiring and MOSFET is superior to that of the conventional high-density plasma CVD Si02 (HDP Si04 ILD. A new via formation process using an NH3 plasma treatment achieves low via resistance of 4 Cl at 0.28 pm in diameter. In addition, the device performance is also improved by the 25 % reduction in wiring capacitance.
Biogenetic-type synthesis of penicillin-cephalosporin antibiotics. II. Oxidative cyclization route to .beta.-lactam thiazoline derivatives (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBiogenetic-type synthesis of penicillin-cephalosporin antibiotics. II. Oxidative cyclization route to .beta.-lactam thiazoline derivativesShinichi Nakatsuka, Hideo Tanino, and Yoshito KishiCite this: J. Am. Chem. Soc. 1975, 97, 17, 5010–5012Publication Date (Print):August 1, 1975Publication History Published online1 May 2002Published inissue 1 August 1975https://pubs.acs.org/doi/10.1021/ja00850a043https://doi.org/10.1021/ja00850a043research-articleACS PublicationsRequest reuse permissionsArticle Views196Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Figure S3 from MEK plus PI3K/mTORC1/2 Therapeutic Efficacy Is Impacted by <i>TP53</i> Mutation in Preclinical Models of Colorectal Cancer (2023)

&lt;p&gt;Figure S3. p53 proficiency is required to induce apoptosis in CRC cell lines and tumors upon anti MEK- and mTOR-inhibition&lt;/p&gt;