gebhart/patrepeval huggingface dataset:
Stable Mixed-Conducting Bilayer Membranes for Direct Conversion of Methane to Syngas (2002)

Results on the oxygen permeability and stability of perovskite-type (LSCF) coated with (SDC) are presented. Bilayer structures were formed by depositing a thin layer of SDC by pulsed laser deposition (PLD) on the reducing side of the membrane. Oxygen permeation fluxes measured with air on the feed side and mixtures on the sweep or reducing side are compared with noncoated results. With the introduction of into the He sweep, LSCF samples exhibit very high oxygen flux values but degrade rapidly as the membrane decomposes to less conductive phases. In contrast, LSCF/SDC bilayer membranes under similar conditions show superior stability and increased oxygen flux over a period of greater than 50 h. During reaction runs with a cyclic redox reaction with respect to ceria was observed and is believed to be due to oscillations in the at the SDC/gas interface. © 2002 The Electrochemical Society. All rights reserved.
Activation of rabbit platelets by Ca2+ influx and thromboxane A2 release in an external Ca2+‐dependent manner by zooxanthellatoxin‐A, a novel polyol (1995)

1. Zooxanthellatoxin-A (ZT-A), a novel polyhydroxylated long chain compound, isolated from a symbiotic marine alga Simbiodinium sp., caused aggregation in rabbit washed platelets in a concentration-dependent manner (1-4 microM), accompanied by an increase in cytosolic Ca2+ concentration ([Ca2+]i). 2. ZT-A did not cause platelet aggregation or increase [Ca2+]i in a Ca(2+)-free solution, and Cd2+ (0.1-1 mM), Co2+ (1-10 mM) and Mn2+ (1-10 mM) inhibited ZT-A-induced aggregation. SK&F96365 (1-100 microM), a receptor operated Ca2+ channel antagonist, and mefenamic acid (0.1-10 microM), a non-specific divalent cation channel antagonist, inhibited platelet aggregation and the increase in [Ca2+]i induced by ZT-A. 3. Indomethacin (0.1-10 microM), a cyclo-oxygenase inhibitor, and SQ-29548 (0.1-10 microM), a thromboxane A2 (TXA2) receptor antagonist, inhibited platelet aggregation and the increase in [Ca2+]i induced by ZT-A. 4. Methysergide (0.01-1 microM), a 5-HT2 receptor antagonist, inhibited ZT-A-induced platelet aggregation but did not affect the increase in [Ca2+]i induced by ZT-A. 5. Tetrodotoxin (1 microM), a Na+ channel blocker and chlorpheniramine (1 microM), a H1-histamine receptor antagonist, neither affected ZT-A-induced platelet aggregation nor the increase in [Ca2+]i induced by ZT-A. 6. Genistein (1-100 microM), a protein tyrosine kinase inhibitor, and staurosporine (0.01-1 microM), a protein kinase C inhibitor, also inhibited ZT-A-induced platelet aggregation. 7. The present results suggest that ZT-A elicits Ca(2+)-influx from platelet plasma membranes. The resulting increase in [Ca2+]i subsequently stimulates the secondary release of TXA2 from platelets. Furthermore, the response to ZT-A may be associated with tyrosine phosphorylation.
The ASM Journals Committee Values the Contributions of Black Microbiologists (2020)

Click to increase image sizeClick to decrease image size NotesEd. Note: This editorial is being published by the following ASM journals: Antimicrobial Agents and Chemotherapy, Applied and Environmental Microbiology, Clinical Microbiology Reviews, EcoSal Plus, Infection and Immunity, Journal of Bacteriology, Journal of Clinical Microbiology, Journal of Microbiology and Biology Education, Journal of Virology, Microbiology and Molecular Biology Reviews, Microbiology Resource Announcements, Microbiology Spectrum, Molecular and Cellular Biology, mBio, mSphere, and mSystems.
Visual search applications for connecting published works to digital material (2010)

Visual search connects physical (offline) objects with (online) digital media. Using objects from the environment, like newspapers, magazines, books and posters, we can retrieve supplemental information from the online world. In this demonstration, we show a framework for delivering visual search services to users of mobile devices. We show how users can point a mobile device at any location in a document, magazine or book to view related, online material on the device. We describe client applications now being deployed for the iPhone and the server architecture used for recognition of scanned images.
Requirements for web-based integrated management systems in the production of image processing components (2019)

New and revised standards are increasing the demands placed on management systems. The aim of this paper is to investigate how the effort required to create and maintain management systems can be minimized. A concept is presented, which also considers the integration of different management systems. First the existing management systems are evaluated. Then the requirements from practice are determined. These are examined and evaluated. Based on both results it is determined which requirements an integrated management system must fulfil. On this basis, a practical concept of an integrated management system is developed. As well optimal interfaces are considered. This concept is transferred into a web-based application. In order to ensure an optimal implementation and expandability, the structure is realized modularly.
Optical synchronization between a dissipative Kerr soliton and a chip-scale mode-locked laser (2021)

A 305 GHz dissipative Kerr soliton is synchronized to a chip-scale 10GHz mode-locked laser through regenerative harmonic injection locking, the repetition rate stability of the mode-locked laser after synchronization is shown to be 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">−9</sup> at 100 ms.
Des bactéries lactiques, alliées potentielles contre les mammites bovines (2015)

Les mammites bovines representent un cout economique et sanitaire important pour la production laitiere dans le monde. La prevention et le traitement des mammites reposent essentiellement sur les vaccins et l’antibiotherapie, dont l’efficacite est limitee, incitant a explorer de nouvelles strategies. Ces dernieres annees, l'utilisation de micro-organismes probiotiques pour lutter contre les infections suscite un interet croissant en sante humaine et animale. Le but de cette etude etait d'isoler des bacteries lactiques (BL) du microbiote mammaire bovin presentant des proprietes benefiques pour la prevention et le traitement des mammites.
L'echantillonnage realise au niveau du canal du trayon a permis l'isolement de 165 clones appartenant principalement aux genres Enterococcus, Streptococcus, Lactobacillus et Lactococcus. Parmi ces isolats, 10 souches appartenant aux genres Lactobacillus et Lactococcus, et non redondantes d’apres leur profil PFGE, ont ete retenues pour etre caracterisees vis-a-vis de leurs proprietes de surface (hydrophobicite, autoaggregation), leur capacite a inhiber les trois agents majoritairement impliques dans les mammites bovines (i.e.Staphylococcus aureus, Escherichia coli et Streptococcus uberis), leurs capacites d'adhesion
et d’internalisation aux cellules epitheliales mammaires bovines et leurs proprietes immunomodulatrices.
Trois souches, deux Lactobacillus brevis et un Lactobacillus plantarum, presentent de fortes capacites de colonisation et constituent de bons candidats pour limiter la colonisation de la glande mammaire par les pathogenes. Par ailleurs, neuf souches de BL presentent des proprietes anti-inflammatoires : la secretion d’IL8 par des cellules epitheliales mammaires bovines stimulees par E. coli est en effet reduite en presence de ces BL. Le sequencage du genome complet de cinq de ces souches candidates a permis de verifier l’absence de facteurs de risque tels que des genes d’antibioresistance et d’identifier des determinants bacteriens
potentiels en lien avec les proprietes probiotiques observees. Ce travail ouvre de nouvelles perspectives sur le developpement de solutions alternatives et durables pour le controle des mammites bovines.
Towards Field Sampling of Ultrabroadband Continuum Radiation from deep-UV to NIR (2022)

We generate an ultrabroadband continuum (DUV - NIR) in a gas-filled hollow-core fiber and aim to measure its electric field oscillations with nonlinear photoconductive sampling (NPS), hence extending the NPS bandwidth across the DUV.
Structure−Activity Relationships in 1,4-Benzodioxan-Related Compounds. 8. {2-[2-(4-Chlorobenzyloxy)phenoxy]ethyl}-[2-(2,6-dimethoxyphenoxy)ethyl]amine (Clopenphendioxan) as a Tool to Highlight the Involvement of α1D- and α1B-Adrenoreceptor Subtypes in the Regulation of Human PC-3 Prostate Cancer Cell Apoptosis and Proliferation (2005)

A series of new alpha1-adrenoreceptor antagonists (5-18) was prepared by introducing various substituents (Topliss approach) into the ortho, meta, and para positions of the benzyloxy function of the phendioxan open analogue 4 ("openphendioxan"). All the compounds synthesized were potent antagonists and generally displayed, similarly to 4, the highest affinity values at alpha1D- with respect to alpha1A- and alpha1B-AR subtypes and 5-HT1A subtype. By sulforhodamine B (SRB) assay on human PC-3 prostate cancer cells, the new compounds showed antitumor activity (estimated on the basis of three parameters GI50, TGI, LC50), at low micromolar concentration, with 7 ("clopenphendioxan") exhibiting the highest efficacy. Moreover, this study highlighted for the first time alpha1D- and alpha1B-AR expression in PC3 cells and also demonstrated the involvement of these subtypes in the modulation of apoptosis and cell proliferation. A significant reduction of alpha1D- and alpha1B-AR expression in PC3 cells was associated with the apoptosis induced by 7. This depletion was completely reversed by norepinephrine.
Coarse Trajectory Design for Energy Minimization in UAV-Enabled (2020)

In this paper, we design the UAV trajectory to minimize the total energy consumption while satisfying the requested timeout (RT) requirement and energy budget, which is accomplished via jointly optimizing the path and UAV's velocities along subsequent hops. The corresponding optimization problem is difficult to solve due to its non-convexity and combinatorial nature. To overcome this difficulty, we solve the original problem via two consecutive steps. Firstly, we propose two algorithms, namely heuristic search, and dynamic programming (DP) to obtain a feasible set of paths without violating the GU's RT requirements based on the traveling salesman problem with time window (TSPTW). Then, they are compared with exhaustive search and traveling salesman problem (TSP) used as reference methods. While the exhaustive algorithm achieves the best performance at a high computation cost, the heuristic algorithm exhibits poorer performance with low complexity. As a result, the DP is proposed as a practical trade-off between the exhaustive and heuristic algorithms. Specifically, the DP algorithm results in near-optimal performance at a much lower complexity. Secondly, for given feasible paths, we propose an energy minimization problem via a joint optimization of the UAV's velocities along subsequent hops. Finally, numerical results are presented to demonstrate the effectiveness of our proposed algorithms. The results show that the DP-based algorithm approaches the exhaustive search's performance with a significantly reduced complexity. It is also shown that the proposed solutions outperform the state-of-the-art benchmarks in terms of both energy consumption and outage performance.
Human alpha-L-iduronidase (IDUA) gene: apparent recombination in intron 2 by haplotype analysis in a Taiwanese population. (1998)

The polymorphic DNA haplotype of the alpha-L-iduronidase (IDUA) gene in a Taiwanese population was investigated. Genomic DNA extracted from 85 volunteers was used to amplify fragments containing the polymorphic sites A8, A20 and Q33H from exon 1 and a variable number of tandem repeats (VNTR) region in intron 2. Additionally, sites R105Q and L118 in exon 3, A314 from exon 7, A361T and T388 from exon 8, T410 and V454I from exon 9, and R489 from exon 10 were amplified. The polymerase chain reaction-amplified products were analyzed by restriction fragment length polymorphism (RFLP) analysis, allele specific oligonucleotide (ASO) hybridization, or gel electrophoresis. Of the examined polymorphisms, the intron 2 VNTR was not in Hardy-Weinberg equilibrium. Conversely, all 11 single base change polymorphisms were in Handy-Weinberg equilibrium. Linkage disequilibrium analysis of the haplotype data revealed strong nonrandom association between A8 and A20 in exon 1 as well as among R105Q, A314, A361T, T388, T410, V454I, and R489 in exons 3 to 10. In contrast, little linkage disequilibrium between two clusters of linked polymorphisms on either side of the VNTR was observed. The results suggest apparent recombination in intron 2 of the IDUA gene, with little or no recombination in exon 1 or exons 3 to 10.
A Novel Triazole Nucleoside Suppresses Prostate Cancer Cell Growth by Inhibiting Heat Shock Factor 1 and Androgen Receptor (2015)

A novel triazole nucleoside analogue was discovered to exhibit potent anticancer activity in prostate cancer cells via down-regulating heat shock factor 1 (HSF1) and related heat shock proteins, along with the consequential inhibition of androgen receptor (AR) expression and transactivation, arresting the cell cycle in AR-governed phase. This triazole nucleoside therefore constitutes a novel structural paradigm and potential drug candidate for prostate cancer through inhibition of HSF1 and AR.
ChemInform Abstract: Renin Inhibitors with Fluorine‐Containing Amino Acid Derivatives (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A phase I clinical trial of PSMA-directed/TGFβ-insensitive CAR-T cells in metastatic castration-resistant prostate cancer. (2019)

TPS347 Background: Adoptive immunotherapy with Chimeric Antigen Receptor (CAR)-T cells has transformative potential for the treatment of cancer. However, a primary challenge to the success of these therapies in prostate cancer is the immunosuppressive microenvironment, including high levels of Transforming Growth Factor-beta (TGFβ), encountered by re-directed T cells upon tumor infiltration. Importantly, these immunosuppressive functions of TGFβ can be abrogated in T cells using a dominant negative TGFβ receptor (TGFβRdn), thereby enhancing antitumor immunity. In in vivo disseminated prostate cancer models, co-expression of TGFβRdn on PSMA-redirected CAR-T cells led to increased T cell proliferation, enhanced cytokine secretion, resistance to exhaustion, long-term persistence, and greater tumor eradication. Methods: We initiated a first-in-human phase 1 clinical trial to evaluate the safety and preliminary efficacy of lentivirally-transduced PSMA-directed/TGFβ-insensitive CAR-T cells (CART-PSMA-TGFβRdn) in men with metastatic CRPC. In preliminary dose-escalation cohorts, patients received a single dose of 1-3 x 10 7 /m 2 (Cohort 1) or 1-3 x 10 8 /m 2 (Cohort 2) CART-PSMA-TGFβRdn cells without lymphodepleting chemotherapy in a 3+3 design. In Cohort 3, patients will receive the MTD of CART-PSMA-TGFβRdn following a lymphodepleting regimen of cyclophosphamide and fludarabine. All patients provide newly obtained metastatic tumor biopsies at baseline, as well as on day +10 following the CAR-T cell infusion and at disease progression. CAR-T expansion and persistence in peripheral blood and trafficking to target tissues is evaluated via quantitative PCR of CART-PSMA-TGFβRdn DNA. Bioactivity of CART-PSMA-TGFβRdn cells is evaluated via multiplex immunoassays. Additional correlative studies include enumeration and phenotyping of circulating tumor cells and DNA. Cohorts 1 and 2 have been completed without observed DLT. Interestingly, a reversible cytokine release syndrome has been observed that is responsive to tocilizumab. Enrollment in Cohort 3 began in September 2018. Cohort expansions will examine serial CART-PSMA-TGFβRdn re-treatment strategies. Clinical trial information: NCT03089203.
Noise Covariance Matrix Estimation for Rotating Microphone Arrays (2018)

The noise covariance matrix computed between the signals from a microphone array is used in the design of spatial filters and beamformers with applications in noise suppression and dereverberation. This paper specifically addresses the problem of estimating the covariance matrix associated with a noise field when the array is rotating during desired source activity, as is common in head-mounted arrays. We propose a parametric model that leads to an analytical expression for the microphone signal covariance as a function of the array orientation and array manifold. An algorithm for estimating the model parameters during noise-only segments is proposed and the performance shown to be improved, rather than degraded, by array rotation. The stored model parameters can then be used to update the covariance matrix to account for the effects of any array rotation that occurs when the desired source is active. The proposed method is evaluated in terms of the Frobenius norm of the error in the estimated covariance matrix and of the noise reduction performance of a minimum variance distortionless response beamformer. In simulation experiments the proposed method achieves 18 dB lower error in the estimated noise covariance matrix than a conventional recursive averaging approach and results in noise reduction which is within 0.05 dB of an oracle beamformer using the ground truth noise covariance matrix.
ChemInform Abstract: Stereoselective Synthesis of Enamides by a Peterson Reaction Manifold. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A Low Jitter Programmable Clock Multiplier Based on a Pulse Injection-Locked Oscillator With a Highly-Digital Tuning Loop (2009)

This paper introduces a pulse injection-locked oscillator (PILO) that provides low jitter clock multiplication of a clean input reference clock. A mostly-digital feedback circuit provides continuous tuning of the oscillator such that its natural frequency is locked to the injected frequency. The proposed system is demonstrated with a prototype consisting of a custom 0.13 mum integrated circuit with active area of 0.4 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and core power of 28.6 mW, along with an FPGA, a discrete DAC and a simple RC filter. Using a low jitter 50 MHz reference input, the PILO prototype generates a 3.2 GHz output with integrated phase noise, reference spur, and estimated deterministic jitter of 130 fs (rms), -63.9 dBc, and 200 fs (peak-to-peak), respectively.
Arsenic trioxyde in the treatment of HTLV1 associated ATLL (2011)

Background The prognosis of Adult T-cell leukemia/lymphoma (ATLL) associated with HTLV1 is dismal. The response to conventional chemotherapy ranges between 20 and 70% and relaspe is constant. Median survival is 8 to 13 months. Chronic and smouldering ATLL have a longer survival, ranging from 18 to 72 months at 5 years. Interferon alpha (IFNa) and AZT combination therapy is effective in acute, chronic and smouldering ATLL, sometimes leading to complete response and has a better prognosis than conventional chemotherapy (5 year survival of 82% in acute and 100% in chronic and smouldering forms reaching a complete response). Patients with ATLL/lymphoma do not benefit from IFNa+AZT combination and despite initial response to chemotherapy, all patients eventually relapse. Arsenic trioxyde (AsO3) in combination with IFNa has in vitro activity with a negative regulation of the Tax oncoprotein and leads to apoptosis of HTLV1 transformed lymphocytes. A recent study has showed a benefit in chronic forms of ATLL.
ChemInform Abstract: Enantioselective Synthesis of 1,2,3‐Trisubstituted Cyclopropanes Using gem‐Dizinc Reagents. (2010)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Energy Efficiency Optimization Technique for SWIPT-Enabled Multi-Group Multicasting Systems with Heterogeneous Users (2021)

We consider a multi-group (MG) multicasting (MC) system wherein a multi-antenna transmitter serves heterogeneous users capable of either information decoding (ID) or energy harvesting (EH), or both. In this context, we investigate a precoder design framework to explicitly serve the ID and EH users categorized within certain MC and EH groups. Specifically, the ID users are categorized within multiple MC groups while the EH users are a part of single (last) group. We formulate a problem to optimize the energy efficiency in the considered scenario under a quality-of-service (QoS) constraint. An algorithm based on Dinkelback method, slack-variable replacement, and second-order conic programming (SOCP)/semi-definite relaxation (SDR) is proposed to obtain a suitable solution for the above-mentioned fractional-objective dependent non-convex problem. Simulation results illustrate the benefits of proposed algorithm under several operating conditions and parameter values, while drawing a comparison between the two proposed methods.
Historical Perspectives and Evolution of Menstrual Terminology (2022)

Abnormal uterine bleeding (AUB) in the reproductive years in non-pregnant women comprises a group of symptoms that include abnormal frequency and the irregular onset of flow as well as prolonged and heavy menstrual bleeding. It is a common, chronic, and debilitating condition affecting women worldwide with an adverse impact on their quality of life. Until the last decade, the "menstrual" terminology used to describe both normal and abnormal uterine bleeding and its underlying causes was inconsistent, creating considerable confusion. Using standardized terminology may potentially improve clinical management as well as help designing and interpreting basic, translational, epidemiological, and clinical research in women with menstrual problems. In this article, we explore the history and evolution of menstrual terminology and discuss the two International Federation of Gynecology and Obstetrics (FIGO) systems on i.e., (A) menstrual terminology and definitions (B) and the causes of AUB, achieved through international consensus of relevant stakeholders through a long multistage journey.