gebhart/patrepeval huggingface dataset:
Poly-1,4-diketones obtained by the Stetter reaction: a new route to conducting heterocyclic polymers (1988)

The electrically conducting, alternating copolymers para-phenylene-2,5-pyrrole and para-phenylene-2,5-thiophene were prepared by the Stetter reaction followed by ring closure and subsequent doping with I2 or AsF5.
A Dutch window into the development of a two tier healthcare system (2010)

May we fire a warning shot across the bows—to use a maritime analogy, as is common in the Netherlands—with regard to the renegotiation of contracts in the next phase of the development of independent sector treatment centres? These centres were originally designed (partly) to introduce “apparent” healthy competition into the “inefficient” NHS in England. We say “apparent,” as we would like to emphasise that, contrary to what’s being touted, when it comes to competition it is certainly not a level playing field, to use a more British expression (as they are all level here in the Netherlands). This was brought home to us in a vivid and extreme example while reviewing a patient at the VU Medical Centre in Amsterdam, where private healthcare providers have been in competition for a number of years.

A man with rather benign but definite multiple sclerosis was re-referred to the VU’s multiple sclerosis centre at the request of a private orthopaedic clinic. He had been …
Chiral homoenolate anion equivalents: synthesis of optically pure 5-substituted furan-2(5H)-ones (1984)

Addition of the dianion of (+)-(R)-3-[(4-methylphenyl)sulphinyl]propionic acid (1) to aldehydes affords two main diastereoisomeric β-sulphinyl-γ-lactones, pyrolysis of which gives the two enantiomers of 5-substituted furan-2(5H)-ones in optically pure form.
Abstract 11411: Plasminogen Facilitates Foam Cell Formation by Macrophages Utilizing H2B and PAR1 (2019)

Plasminogen (Plg) is the zymogen form of plasmin, the serine protease primarily responsible for degrading fibrin within blood clots. Plg mediates many of its functions by binding to the Plg recepto...
Enhancement-Mode AlGaN/GaN MIS-HEMTs With High VTH and High IDmax Using Recessed-Structure With Regrown AlGaN Barrier (2020)

We report on an Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> /AlGaN/GaN metalinsulator-semiconductor high-electron-mobility transistor (MIS-HEMT) with recessed-gate structure and regrown AlGaN barrier. After analyzing the possibility of obtaining high threshold voltage (V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> ) within the framework of Tapajna and Kuzmik model from preliminary experiments using MIS-diode structures, we fabricated a MIS-HEMT with the same materials and structures. The transistor exhibited a highVth value of +2.3 V determined at the drain current criterion of 10 <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">μ</sub> A/mm together with a maximum drain current density (I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Dmax</sub> ) of 425 mA/mm. We believe that the adoption of a technology, i. e., AlGaN regrowth on dryetched GaN surface, previously demonstrated by our group in planar device, is the main key for achieving such desirable performance.
Investigating complex-valued neural networks applied to phase-cycled bSSFP for multi-parametric quantitative tissue characterization (2023)

The bSSFP sequence is highly sensitive to relaxation parameters, tissue microstructure, and off-resonance frequencies, which has recently been shown to enable multi-parametric tissue characterization in the human brain using real-valued NNs. In this work, a new approach based on complex-valued NNs for voxel-wise simultaneous multi-parametric quantitative mapping with phase-cycled bSSFP input data is presented, possibly facilitating data handling. Relaxometry parameters (T1, T2) and field map estimates (B1 + , &amp;Delta;B0) could be quantified with high robustness and accuracy. The quantitative results were compared for different activation functions, favoring phase-sensitive implementations.
Reduction in the duration of myelotoxicity associated with radioimmunotherapy with infusions of the hemoregulatory peptide, HP5b in mice (1997)

The hemoregulatory peptide, pGlu-Glu-Asp-Cys-Lys (pEEDCK or HP5b), has been shown to reversibly inhibit the proliferation of bone-marrow progenitor cells, and has been reported to protect mice from the myelotoxicity associated with ara-C, a chemotherapeutic agent. We undertook to use this reagent to reduce radioimmunotherapy(RAIT)-associated bone-marrow toxicity by suppressing hematopoiesis during the critical period when bone marrow is exposed to radiation. The reported studies optimize the use of HP5b to reduce the duration of neutropenia and thrombocytopenia. We found that 3.6 micrograms/day of HP5b administered through a continuous 7d mini-osmotic pump, together with a bolus dose of 3.6 micrograms 3 hours before the radioantibody dose, gave the best effect, as measured by neutrophil counts on day 28 post RAIT. With sub-lethal doses of RAIT, the period of neutropenia was reduced by 2 weeks, and there appeared to be more rapid recovery of morphologically mature myeloid cells. The peptide, however, does not appear to alleviate the lymphotoxicity associated with RAIT. No adverse effects have been noted from continuous infusions of the peptide. In the past, we reported that cytokines (IL-I/GM-CSF) are not marrow-restorative when given after RAIT. However, an additive effect is observed when HP5b infusions are combined with post-RAIT cytokine administration, suggesting that a significant pool of bone-marrow progenitor cells remains when HP5b is co-administered with RAIT. Thus, HP5b is an alternate approach to reducing myelotoxicity, and may be used in combination with cytokines to further reduce the duration of myelosuppression.
Plasmonic Nanoantennas: Lateral Magnetic Near‐Field Imaging of Plasmonic Nanoantennas With Increasing Complexity (Small 10/2014) (2014)

Imaging the magnetic field of light, important, for example, in metamaterials studies, only recently became possible. D. Denkova, V. V. Moshchalkov, and co-workers image the lateral magnetic near-field distributions of different plasmonic antennas by aperture near-field microscopy. The results, presented on page 1959, contribute to the development of novel plasmonic metamaterials.
Accurate Volumetric-Flow-Rate- and Density-Based Water-Cut Measurement in Bubbly Liquid Hydrocarbon Flow (2006)

Abstract Oil and gas production is inherently multiphase. A significant cost of production is directed toward accurately measuring and allocating produced hydrocarbons. The presence of gas phase in liquid flow impairs accurate measurement, introducing errors in well and field production allocation. These errors distort the reservoir engineer production information and directly affect the fiscal allocation from multiple owners. A SONAR-based system to measure the gas void fraction (GVF) next to turbine and Coriolis meters is proposed as a method to correct for gas bubbles. A test was conducted at Southwest Research Institute (SwRI) to validate this concept on realistic multiphase fluids. The SwRI test was designed to simulate separator liquid out-flow conditions and to assess the ability of GVF measurement to correct for the errors introduced by entrained gas in turbine and Coriolis meters. The data show that both the turbine and Coriolis meters over-report the volumetric flow rate in proportion to the amount of entrained gas. Using a GVF measurement provides a simple correction to the primary measurement of both meter types to within ±1% of the reference liquid flow rate for 0–8% GVF. The Coriolis meter correctly measured the mixture (liquid + gas) density within ±1% of the reference, independent of entrained gas levels. The liquid density is required to determine water-cut and in this test it was calculated by correcting the measured mixture density for GVF. Using a simple GVF correction, the liquid density was reported to within ±1% for 0–10% GVF. An accurate measure of liquid hydrocarbon volumetric flow rate and density independent of the amount of entrained gas can be achieved using turbine and Coriolis meters in conjunction with a SONAR-based GVF measurement. This capability enables improved reservoir management as well as increased separator design flexibility, reducing complexity, cost and weight.
Pazopanib Reduces Phosphorylated Tau Levels and Alters Astrocytes in a Mouse Model of Tauopathy (2017)

Hyperphosphorylation and aggregation of tau protein is a critical factor in many neurodegenerative diseases. These diseases are increasing in prevalence, and there are currently no cures. Previous work from our group and others has shown that tyrosine kinase inhibitors (TKIs) can stimulate autophagy, decrease pathological proteins, and improve symptoms in models of neurodegeneration. Here we examined the role of pazopanib in mouse models that express either human mutant P301L tau (TauP301L) or triple mutant amyloid precursor protein (3x-AβPP). The TauP301L mouse expresses P301L tau under the control of a prion promoter in both neurons and astrocytes, reminiscent of some human tauopathies. Pazopanib crosses the blood-brain barrier with no detectable peripheral off-side effects, and decreases p-tau in TauP301L mice. Pazopanib reaches a brain concentration sufficient for inhibition of several tyrosine kinases, including vascular endothelial growth factor receptors (VEGFRs). Further, pazopanib does not affect microglia but reduces astrocyte levels toward nontransgenic controls in TauP301L mice. Pazopanib does not alter amyloid beta levels or astrocytes in 3x-AβPP mice but modulates a number of inflammatory markers (IP-10, MIP-1α, MIP-1β, and RANTES). These data suggest that pazopanib may be involved in p-tau clearance and modulation of astrocytic activity in models of tauopathies.
Simple electroabsorption calculator for germanium quantum well devices (2011)

We present a simple quantum well electroabsorption calculator (SQWEAC) for the germanium material system to facilitate optoelectronic modulator design. We show SQWEAC is valid for a range of quantum well sizes and growth conditions.
Resilient Distributed Recovery of Large Fields (2020)

This paper studies the resilient distributed recovery of large fields under measurement attacks, by a team of agents, where each measures a small subset of the components of a large spatially distributed field. An adversary corrupts some of the measurements. The agents collaborate to process their measurements, and each is interested in recovering only a fraction of the field. We present a field recovery consensus+innovations type distributed algorithm that is resilient to measurement attacks, where an agent maintains and updates a local state based on its neighbors states and its own measurement. Under sufficient conditions on the attacker and the connectivity of the communication network, each agent's state, even those with compromised measurements, converges to the true value of the field components that it is interested in recovering. Finally, we illustrate the performance of our algorithm through numerical examples.
Quantitative Image Analysis in Cardiac CT Angiography (2010)

Despite advances in diagnosis, treatment and interventions, cardiovascular disease
remains a major health problem in the western world. Owing to the ageing society
and changing lifestyle, cardiovascular disease affects an increasing number of
individuals. Often, there are no symptoms prior to clinical cardiovascular
disease related events such as myocardial infarction (heart attack), and irreversible
damage or death may occur prior to any medical intervention. Advances in
imaging technology have great potential to improve the management of cardiovascular
disease through early detection, improved diagnosis and treatment monitoring
[30]. This requires not only advanced techniques to image cardiovascular
anatomy and function, but also robust methods to extract relevant (quantitative)
parameters from these imaging data and novel techniques that effectively visualize
diagnostically relevant image information.
This thesis describes the development and validation of quantitative image analysis
and visualization methods, which are essential steps towards improved imagebased
diagnosis and prognosis of cardiovascular disease. In the subsequent sections
we will introduce the cardiac anatomy, coronary artery disease, CT angiography
(CTA) imaging of the coronary arteries, and methods for quantitative CTA image
analysis. Following the introduction, we will provide an outline of this thesis in
Section 1.2.
<title>Analysis of one-way coupling between asymmetric highly multimode waveguides</title> (1997)

In this paper, a unidirectional electrooptic modulator based on an asymmetrical highly multi-mode wavedguide coupler is proposed. The energy distribution of all the guided modes within a highly multi-mode waveguide is studied and a new conclusion is obtained. Furthermore, the whole coupling process among all the guided modes between two nonidentical highly multi-mode waveguides is analyzed and the total coupling efficiency is calculated. To achieve high switching performance in a guided-wave coupler, a larger guide is made to have a dumping effect, which can be implemented by using an absorbing material or a grating. Based on the dumping effect, the dumping process is theoretically modeled and the dumping efficiency is simulated. Not only can a high dumping efficiency of 100 percent be achieved, but a high electrooptic modulation depth more than 90 percent can also be implemented.
Enhanced Reprogramming and Cardiac Differentiation of Human Keratinocytes Derived from Plucked Hair Follicles, Using a Single Excisable Lentivirus (2010)

Induced pluripotent stem cells (iPSCs) represent an ideal cell source for future cell therapy and regenerative medicine. However, most iPSC lines described to date have been isolated from skin fibroblasts or other cell types that require harvesting by surgical intervention. Because it is desirable to avoid such intervention, an alternative cell source that can be readily and noninvasively isolated from patients and efficiently reprogrammed, is required. Here we describe a detailed and reproducible method to derive iPSCs from plucked human hair follicle keratinocytes (HFKTs). HFKTs were isolated from single plucked hair, then expanded and reprogrammed by a single polycistronic excisable lentiviral vector. The reprogrammed HFKTs were found to be very sensitive to human embryonic stem cell (hESC) growth conditions, generating a built-in selection with easily obtainable and very stable iPSCs. All emerging colonies were true iPSCs, with characteristics typical of human embryonic stem cells, differentiated into derivatives of all three germ layers in vitro and in vivo. Spontenaeouly differentiating functional cardiomyocytes (CMs) were successfully derived and characterized from these HFKT-iPSCs. The contracting CMs exhibited well-coordinated intracellular Ca²+ transients and contractions that were readily responsive to β-adrenergic stimulation with isoproterenol. The introduction of Cre-recombinase to HFKT-iPSC clones was able to successfully excise the integrated vector and generate transgene-free HFKT-iPSC clone that could be better differentiated into contracting CMs, thereby revealing the desired cells for modeling human diseases. Thus, HFKTs are easily obtainable, and highly reprogrammed human cell source for all iPSC applications.
Extracellular Transglutaminase 2 Is Catalytically Inactive, but Is Transiently Activated upon Tissue Injury (2008)

Transglutaminase 2 (TG2) is a multifunctional mammalian protein with transamidase and signaling properties. Using selective TG2 inhibitors and tagged nucleophilic amine substrates, we show that the majority of extracellular TG2 is inactive under normal physiological conditions in cell culture and in vivo. However, abundant TG2 activity was detected around the wound in a standard cultured fibroblast scratch assay. To demonstrate wounding-induced activation of TG2 in vivo, the toll-like receptor 3 ligand, polyinosinic-polycytidylic acid (poly(I:C)), was injected in mice to trigger small intestinal injury. Although no TG2 activity was detected in vehicle-treated mice, acute poly(I:C) injury resulted in rapid TG2 activation in the small intestinal mucosa. Our findings provide a new basis for understanding the role of TG2 in physiology and disease.
BN++ – A Biological Information System (2006)

Summary Recent years have seen an explosive growth in the amount of biochemical data available. Numerous databases have been established and are being used as an essential resource by biologists around the world. The sheer amount and heterogeneity of these data poses a major challenge: data integration and, based thereupon, the integrative analysis of these data. We present BN++, the biochemical network library, a powerful software package for integrating, analyzing, and visualizing biochemical data in the context of networks. BN++ is based on a comprehensive and extensible object model (BioCore), which has been implemented as a C++ framework, a Java class library, and a relational database. The C++ framework is used to efficiently import, integrate, and analyze the data, which is stored in a data warehouse. The Java-based viewer (BiNA) provides a powerful platform-independent visualization of the data using sophisticated graph layout algorithms. Currently, the data warehouse imports and integrates data from about a dozen important databases including, among others, sequence data, metabolic and regulatory networks, and protein interaction data. We illustrate the usefulness of BN++ with a few select example applications. Availability: BN++ is open source software available from our website at www.bnplusplus.org.
Cover Feature: Intramolecular [2+2] Cycloaddition of N‐Allylcinnamamines and N‐Allylcinnamamides by Visible‐Light Photocatalysis (Eur. J. Org. Chem. 1/2020) (2019)

The Cover Feature shows the [2+2] photocycloaddition of highly functionalized N-allylcinnamamides and N-allylcinnamamines, that could provide the corresponding aryl-3-azabicyclo[3.2.0]heptanones and aryl-3-azabicyclo[3.2.0]heptanes, respectively. Those compounds are useful as both scaffolds and fragments in drug design and discovery. We thank Dr. John Tokarski at BMS and Accdon, LLC/ LetPub for the cover design. More information can be found in the Full Paper by M. S. Oderinde et al.
One Sub-wavelength Mode Volumes in Silicon Optical Nanocavities (2006)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text J. T. Robinson, S. Preble, and M. Lipson, "One Sub-wavelength Mode Volumes in Silicon Optical Nanocavities," in Integrated Photonics Research and Applications/Nanophotonics, Technical Digest (CD) (Optica Publishing Group, 2006), paper IMD4. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Urea Derivatives of STI571 as Inhibitors of Bcr‐Abl and PDGFR Kinases. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Programming Methodology for Biologically-Inspired Self-Assembling Systems (2003)

We present a programming methodology for self-assembling complex structures from vast numbers of locally-interacting identically-programmed agents, using techniques inspired by developmental biology. We demonstrate this approach through two examples: shape formation on a reconfigurable sheet, and self-assembling two dimensional structures through replication. In each case, the desired global shape is specified using an abstract geometry-based language, and the agent program is directly compiled from the global specification. The resulting
Organic Computing for Video Analysis (2007)

The current interest in organic computing is also sustained by a notion of "organic" which relates to the user rather than the developer. In that aspect, organic computing requires that the interface between the IT system and the user be organic, intelligible, and friendly. This again imposes constraints on the user interfaces. On an abstract level, a recognition systems requires a data format for stored objects, a method to compare given images with those objects, and a method to turn the resulting similarities into a decision about the object's identity. For efficient application to real world data, the efficient organization of the object database and methods to presegment images and image sequences become important. The subsystems to perform these tasks can be designed by using the organic computing principles of "learning from nature" and "self-organization".
[Feasibility study for development of automatic calibration system for clinical laboratory analyzers]. (2009)

This report summarizes the results of a "Feasibility Study for Development of Automatic Calibration System for Clinical Laboratory Analyzers", that was entrusted to the JCCLS (Japanese Committee for Clinical Laboratory Standards) as a project for 2007FY by the Mechanical Social Systems Foundation. The purpose of this study was to establish a calibration system for clinical laboratory analyzers that are commonly used in Japanese laboratories, in order to promote the standardization of clinical tests. Standardization of an automatic calibration system for clinical laboratory analyzers will facilitate accuracy control without having to depend on the skill of laboratory operators, which will achieve the further standardization of clinical tests.
Clinical-Pathological Features of an Occult Mixed Mucinous Male Breast Cancer: A Case Report (2017)

Mucinous carcinoma of the male breast is an uncommon malignant breast neoplasm and its diagnoses remain difficult. It is probably due to such a low rate of breast cancer cases that men tend to be diagnosed at an older age than women and with a later stage of the disease. We describe a case of a 69-year-old male who displayed a palpable lump in his right axilla several years ago, showing signs of cutaneous adnexal mucinous adenocarcinoma after biopsy. After six years and several clinical examination and systemic investigation without results, the patient underwent to fine needle aspiration cytology and subsequently a biopsy of a mass with irregular margins in the retroareolar region of his right breast. The final diagnosis was of a mixed mucinous breast cancer with neuroendocrine differentiation. The tumor cells phenotype showed Synaptophisin (+), CEA (+/-), CK-20 (-), CK-7 (+), TTF-1 (-), estrogen receptor (-), progesterone (-) and HER 2 (++). These results were unusual for a mucinous male breast carcinoma. In the presence of a lesion in the axillary area with no specific primary origin, breast cancer should never be ruled out, even in the absence of clinical evidence and with an immunohistochemical pattern not indicative of mammary origin.
Study on the radiofrequency transparency of electrically floating and ground PET inserts in a 3 T clinical MRI system (2022)

The floating PET configuration showed higher RF transparency under all experimental setups. For a relatively short axial FOV of 125 mm, the ground configuration also performed well which indicated that an RF-penetrable PET insert with the conventional design (e.g., the ground configuration) might also become possible. However, some design modifications (e.g., a wider intermodular gap and using the RF receiver coil inside the PET insert) should improve the RF performance to the level of the MRI-only case.