gebhart/patrepeval huggingface dataset:
Genetic Susceptibility to Diabetes Mellitus: the Distribution of Properdin Factor B (Bf) and Glyoxalase (GLO) Phenotypes (1979)

The distribution of phenotypes controlled by two loci on chromosome 6 has been studied in a series of 239 patients with type 1 (insulin-dependent) and 297 patients with type 2 (non-insulin-dependent) diabetes mellitus. At the properdin factor B (Bf) locus there is a significant increase in the frequency of the BfSu and BfF1 alleles for type 1 patients, and the combined inc;rease in frequency of BfS1 and BfF1 in those patients is highly significant. The relative risk for F1 is 6.2 and for F1 and S1 combined is 5.3. These results confirm the association with F1 reported recently by Raum and co-workers in Boston. The two rare alleles BfS1 and BfF1 are in significant negative disequilibrium with HLA B8. For the glyoxalase (GLO) locus there is a slight but nonsignificant increase in the frequency of the GLO2 allele, but a significant disturbance in the distribution of the GLO phenotypes for type 2 patients. These results for the GLO alleles may be due to stratification in our series of type 2 patients. Further studies are in progress to test this hypothesis.
A 5 x 5 mm Highly Integrated Dual-band WLAN Front-End Module Simplifies 802.11 a/b/g and 802.11n Radio Designs (2007)

A highly integrated 5 x 5 x 0.9 mm3 dual-band Wireless LAN front-end module (FEM) is presented. The FEM features 29 dB gain and 19 dBm at 54Mbps with EVM < 3% and 180 mA for 2.4 to 2.5 GHz. For 4.9 to 5.9 GHz transmission, the FEM delivers 25 dB gain and 17 dBm at 54Mbps with EVM < 3% and 195 mA. The FEMs receive chains can be realized either with LAN having >11.4 dB gain LNA gain with NF < 2.5 dB for the low band and < 2.8 dB for the high band or with used a RX diplexer with <1 insertion loss. The FEM significantly simplifies 802.11 a/b/g radio designs and provides an effective building block for multi-channel 802.11n radios designs.
Phosphodiesterase 11A (PDE11A) Genetic Variants May Increase Susceptibility to Prostatic Cancer (2010)

Abstract Context: Among the genomic loci harboring potential candidate genes for prostatic cancer (PCa) is the 2q31-39 chromosomal region that harbors the gene encoding phosphodiesterase 11A (PDE11A). In addition, the combined cancer genome expression metaanalysis datasets included PDE11A among the top 1% down-regulated genes in PCa. Objective: In the present study, we screened 50 unrelated PCa patients of Brazilian descent for PDE11A coding defects. Design: The study consisted of sequencing of PDE11A, in vitro functional assays, and immunostaining analysis. Results: We identified eight different sequence alterations in 15 patients (30%): one stop-codon and seven missense mutations. Three of the variants (R202C, Y658C, and E840K) were novel, and the remaining five (Y727C, R804H, R867G, M878V, and R307X) have been associated with predisposition to adrenal or testicular tumors. The overall prevalence of PDE11A-inactivating sequence variants among PCa patients was significantly higher than in 287 healthy controls (0.16 vs. 0.051, respectively, P &amp;lt; 0.001, odds ratio 3.81, 95% confidence interval 1.86–7.81) and the R202C, Y658C, and E840K substitutions were not found in controls. All missense mutations led to decreased PDE11A activity in human embryonic kidney 293 and PC3M cells and immunostaining of PCa samples with sequence changes showed decreased PDE11A protein expression. Conclusion: Our data suggest that, like in the adrenal cortex and the testicular germ cells, PDE11A-inactivating genetic alterations may play a role in susceptibility to PCa.
Lonspray mass spectrometry of ciguatoxin‐1, maitotoxin‐2 and ‐3, and related marine polyether toxins (1994)

A range of marine polyether toxins from dinoflagellates were analysed by ionspray mass spectrometry. Ciguatoxin-1 ([M+H]+ m/z = 1,111.8) purified from several fish species yielded singly charged ions corresponding to the parent ion, sodium and H2O adducts and ions for the loss of up to five H2O molecules. Ciguatoxin-1 was detected to 1 ng; however, interference from fish lipids precluded direct detection of ciguatoxin-1 in crude extracts from fish flesh spiked with ciguatoxin-1 at a level equivalent to 1.5 ng ciguatoxin-1/g of extracted flesh. Maitotoxin-2 yielded doubly and triply charged ions for sodium and potassium salts and likely possessed only one sulphate ester (M(r) = 3,298 for the mono-sodium salt). Maitotoxin-3, a recently isolated small maitotoxin, yielded singly charged ions including ions for the loss of one sulphate and up to four H2O molecules. Maitotoxin-3 is proposed to be a polyether compound possessing two sulphate esters (M(r) = 1,060.5 for the disodium salt). Brevetoxin-A ([M+H]+ m/z = 867.5) and brevetoxin-B ([M+H]+ m/z = 895.5) yielded singly charged ions corresponding to the parent ion, Na+ adducts and the loss of up to four H2O molecules. Okadaic acid ([M+H]+ m/z = 805.5) yielded singly charged ions corresponding to the parent ion and ions for the loss of up to three H2O molecules. A signal for M + 18 Da species that may represent [M+NH4]+ was observed for ciguatoxin-1, brevetoxin-A and -B, and okadaic acid. For all polyethers examined, the orifice potential influenced the relative intensity of the ions detected in a predictable manner.(ABSTRACT TRUNCATED AT 250 WORDS)
Quantum Variational Rewinding for Time Series Anomaly Detection (2022)

Electron dynamics, financial markets and nuclear fission reactors, though seemingly unrelated, all produce observable characteristics evolving with time. Within this broad scope, departures from normal temporal behavior range from academically interesting to potentially catastrophic. New algorithms for time series anomaly detection (TAD) are therefore certainly in demand. With the advent of newly accessible quantum processing units (QPUs), exploring a quantum approach to TAD is now relevant and is the topic of this work. Our approach - Quantum Variational Rewinding, or, QVR - trains a family of parameterized unitary time-devolution operators to cluster normal time series instances encoded within quantum states. Unseen time series are assigned an anomaly score based upon their distance from the cluster center, which, beyond a given threshold, classifies anomalous behavior. After a first demonstration with a simple and didactic case, QVR is used to study the real problem of identifying anomalous behavior in cryptocurrency market data. Finally, multivariate time series from the cryptocurrency use case are studied using IBM's Falcon r5.11H family of superconducting transmon QPUs, where anomaly score errors resulting from hardware noise are shown to be reducible by as much as 20% using advanced error mitigation techniques.
Rearrangement of acetylide and vinylidene ligands on the coordination spheres of cluster complexes. Reaction of the trinuclear acetylide cluster CpWOs2(CO)8(C.tplbond.CPh) with mononuclear metal hydride complexes LW(CO)3H (L = Cp, Cp*) (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRearrangement of acetylide and vinylidene ligands on the coordination spheres of cluster complexes. Reaction of the trinuclear acetylide cluster CpWOs2(CO)8(C.tplbond.CPh) with mononuclear metal hydride complexes LW(CO)3H (L = Cp, Cp*)Yun Chi, Chang Ho Wu, Shie Ming Peng, and Gene Hsiang LeeCite this: Organometallics 1991, 10, 6, 1676–1682Publication Date (Print):June 1, 1991Publication History Published online1 May 2002Published inissue 1 June 1991https://pubs.acs.org/doi/10.1021/om00052a012https://doi.org/10.1021/om00052a012research-articleACS PublicationsRequest reuse permissionsArticle Views68Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
One-chip integrated dual polarization optical hybrid using silica-based planar lightwave circuit technology (2009)

We demonstrate a compact dual polarization optical hybrid achieved by the integration of polarization beam splitters and 90°-hybrids using silica-based planar lightwave circuit. The fabricated device exhibited sufficient characteristics for coherent systems such as DP-QPSK.
Joint Design of Multi-Tap Analog Cancellation and Digital Beamforming\n for Reduced Complexity Full Duplex MIMO Systems (2017)

Incorporating full duplex operation in Multiple Input Multiple Output (MIMO)\nsystems provides the potential of boosting throughput performance. However, the\nhardware complexity of the analog self-interference canceller scales with the\nnumber of transmit and receive antennas, thus exploiting the benefits of analog\ncancellation becomes impractical for full duplex MIMO transceivers. In this\npaper, we present a novel architecture for the analog canceller comprising of\nreduced number of taps (tap refers to a line of fixed delay and variable phase\nshifter and attenuator) and simple multiplexers for efficient signal routing\namong the transmit and receive radio frequency chains. In contrast to the\navailable analog cancellation architectures, the values for each tap and the\nconfiguration of the multiplexers are jointly designed with the digital\nbeamforming filters according to certain performance objectives. Focusing on a\nnarrowband flat fading channel model as an example, we present a general\noptimization framework for the joint design of analog cancellation and digital\nbeamforming. We also detail a particular optimization objective together with\nits derived solution for the latter architectural components. Representative\ncomputer simulation results demonstrate the superiority of the proposed low\ncomplexity full duplex MIMO system over lately available ones.\n
Is a Universal Influenza Virus Vaccine Possible? (2019)

Influenza viruses remain a severe burden to human health because of their contribution to overall morbidity and mortality. Current seasonal influenza virus vaccines do not provide sufficient protection to alleviate the annual impact of influenza and cannot confer protection against potentially pandemic influenza viruses. The lack of protection is due to rapid changes of the viral epitopes targeted by the vaccine and the often suboptimal immunogenicity of current immunization strategies. Major efforts to improve vaccination approaches are under way. The development of a universal influenza virus vaccine may be possible by combining the lessons learned from redirecting the immune response toward conserved viral epitopes, as well as the use of adjuvants and novel vaccination platforms.
CCDC 1445443: Experimental Crystal Structure Determination (2016)

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Austin Replies: (1995)

A Reply to the Comment by Susanna W. Johnson, et al.Received 21 December 1994DOI:https://doi.org/10.1103/PhysRevLett.74.2845©1995 American Physical Society
Consequence of proximal humeral fracture morphology on glenohumeral range of motion (2012)

Introduction The reliability of currently available proximal humeral fracture classi?cation systems has been shown to be poor, giving rise to the question whether a more objective measure entails improved predictability of surgical outcome. This study aims to apply a novel software system to predict the functional range of motion of the glenohumeral joint after proximal humeral fracture. Method Using a validated system that simulates bone-determined range of motion of spheroidal joints such as the shoulder joint, we categorically analysed a consecutive series of 79 proximal humeral fractures. Morphological properties of the proximal humerus fractures were related to simulated bone-determined range of motion. Results The interobserver variability of range of motion assessment using our system showed excellent agreement (0.798). Maximal glenohumeral abduction and forward ?exion of intra-articular fractures were 34.3±6.6 SE and 60.7±12.4 SE degrees. For fractures with a displaced greater tuberosity abduction was 75.0±5.9 SE and forward flexion was 118.2±4.9 SE degrees, whilst for fractures where both tuberosities had been displaced they were 60.0±10.9 SE and 69.6±13.4 SE degrees respectively. For non-intra articular fractures without displaced tuberosities movements were 89.3±3.3 SE and 122.6±3.4 SE degrees respectively. The head inclination angle was positively correlated with maximum abduction (0.362, p = 0.014). Offset was negatively correlated with maximum abduction, but not statistically signi?cant (0.834, p = 0.087). Conclusion This study has demonstrated a novel and effective tool allowing the prediction of functional motion after proximal humeral fracture based on bone anatomy. The study demonstrates that intra-articular fractures generally have the worst prognosis with regards to bone-determined ROM. Fractures with displaced tuberosities show more motion limitations for abduction than for forward ?exion. A reduced head inclination angle is a strong predictor of limited bone-determined range of motion for all types of proximal humerus fractures.
Radiative effects of atmospheric aerosols on optical pulse propagation: Implications to high data rate free space optical (FSO) communication systems (2019)

Free space optical (FSO) communication is a line of sight technology capable of carrying large volume of data using laser signals through the atmosphere. This unguided propagation of laser beams through the atmosphere confronts with turbulent fluctuations and suspended aerosol particles on its en route to the receiver. Random fluctuations in the atmospheric refractive index causes variations in the propagation constant and thereby affects the optical pulse propagation. We examine the local atmospheric warming effects of absorbing aerosols on the atmospheric refractive index fluctuation statistics and its influence on the group velocity dispersion (GVD) parameter. Black Carbon (BC) aerosols increase local temperature through solar absorption, which will be amplified when they reside in the upper atmosphere for longer duration, owing to the reduced atmospheric density prevailing at higher altitudes. To elucidate the implications of elevated BC layer heating on FSO links, vertical BC mass concentration was measured using an Aethalometer (Model AE-42, of Magee Scientific, USA) mounted on a hydrogen filled balloon. Long term analysis of multi-satellite observations along with in-situ measurements of aerosol parameters show dependence of GVD on aerosol induced local atmospheric warming. Effect of warming on outage probability of FSO systems employing chirped Gaussian pulses are also presented.
Matrix-Lifting Semi-Definite Programming for Decoding in Multiple Antenna Systems (2007)

This paper presents a computationally efficient decoder for multiple antenna systems. The proposed algorithm can be used for any constellation (QAM or PSK) and any labeling method. The decoder is based on matrix-lifting Semi-Definite Programming (SDP). The strength of the proposed method lies in a new relaxation algorithm applied to the method of Mobasher et al. This results in a reduction of the number of variables from $(NK+1)^2$ to $(2N+K)^2$, where $N$ is the number of antennas and $K$ is the number of constellation points in each real dimension. Since the computational complexity of solving SDP is a polynomial function of the number of variables, we have a significant complexity reduction. Moreover, the proposed method offers a better performance as compared to the best quasi-maximum likelihood decoding methods reported in the literature.
RFID et l'internet des choses (2010)

RFID et l'internet des choses dresse un panorama des techniques utilisées pour les étiquettes RFID (Radio Frequency Identification) : hardware, protocoles de communications, cryptographie, applications (dont EPC) et finalement intergiciels.Ces cinq parties permettent aux lecteurs d'avoir en un seul ouvrage une description scientifique précise de l'ensemble des éléments constituant les systèmes RFID d'aujourd'hui , en couvrant des problématiques récentes comme le respect de la vie privée ou l'internet des choses.
First evidence for the two-body charmless baryonic decay $ {B^0}\to p\overline{p} $ (2013)

A bstract The results of a search for the rare two-body charmless baryonic decays $ {B^0}\to p\overline{p} $ and $ B_s^0\to p\overline{p} $ are reported. The analysis uses a data sample, corresponding to an integrated luminosity of 0.9 fb −1 , of pp collision data collected by the LHCb experiment at a centre-of-mass energy of 7 TeV. An excess of $ {B^0}\to p\overline{p} $ candidates with respect to background expectations is seen with a statistical significance of 3.3 standard deviations. This is the first evidence for a two-body charmless baryonic B 0 decay. No significant $ B_s^0\to p\overline{p} $ signal is observed, leading to an improvement of three orders of magnitude over previous bounds. If the excess events are interpreted as signal, the 68.3% confidence level intervals on the branching fractions are $ \begin{array}{*{20}{c}} {\mathcal{B}\left( {{B^0}\to p\overline{p}} \right)=1.47_{-0.51-0.14}^{+0.62+0.35}\times {10^{-8 }},} \hfill \\ {\mathcal{B}\left( {{B^s}\to p\overline{p}} \right)=2.84_{-1.68-0.18}^{+2.03+0.85}\times {10^{-8 }},} \hfill \\ \end{array} $ where the first uncertainty is statistical and the second is systematic.
Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer (2021)

Lineage plasticity, the ability of a cell to alter its identity, is an increasingly common mechanism of adaptive resistance to targeted therapy in cancer. An archetypal example is the development of neuroendocrine prostate cancer (NEPC) after treatment of prostate adenocarcinoma (PRAD) with inhibitors of androgen signaling. NEPC is an aggressive variant of prostate cancer that aberrantly expresses genes characteristic of neuroendocrine (NE) tissues and no longer depends on androgens. Here, we investigate the epigenomic basis of this resistance mechanism by profiling histone modifications in NEPC and PRAD patient-derived xenografts (PDXs) using chromatin immunoprecipitation and sequencing (ChIP-seq). We identify a vast network of cis-regulatory elements (N~15,000) that are recurrently activated in NEPC. The FOXA1 transcription factor (TF), which pioneers androgen receptor (AR) chromatin binding in the prostate epithelium, is reprogrammed to NE-specific regulatory elements in NEPC. Despite loss of dependence upon AR, NEPC maintains FOXA1 expression and requires FOXA1 for proliferation and expression of NE lineage-defining genes. Ectopic expression of the NE lineage TFs ASCL1 and NKX2-1 in PRAD cells reprograms FOXA1 to bind to NE regulatory elements and induces enhancer activity as evidenced by histone modifications at these sites. Our data establish the importance of FOXA1 in NEPC and provide a principled approach to identifying cancer dependencies through epigenomic profiling.
Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation (2018)

Monoacylglycerol lipase (MAGL) inhibition provides a potential treatment approach to neuroinflammation through modulation of both the endocannabinoid pathway and arachidonoyl signaling in the central nervous system (CNS). Herein we report the discovery of compound 15 (PF-06795071), a potent and selective covalent MAGL inhibitor, featuring a novel trifluoromethyl glycol leaving group that confers significant physicochemical property improvements as compared with earlier inhibitor series with more lipophilic leaving groups. The design strategy focused on identifying an optimized leaving group that delivers MAGL potency, serine hydrolase selectivity, and CNS exposure while simultaneously reducing log D, improving solubility, and minimizing chemical lability. Compound 15 achieves excellent CNS exposure, extended 2-AG elevation effect in vivo, and decreased brain inflammatory markers in response to an inflammatory challenge.
FABRICATION OF GRAIN BOUNDARY JUNCTIONS USING NdFeAs(O,F) SUPERCONDUCTING THIN FILMS (2018)

We report on the growth of NdFeAs(O,F) thin films on [001]-tilt MgO bicrystal substrates with misorientation angle theta_GB=6{\deg}, 12{\deg}, 24{\deg} and 45{\deg}, and their inter- and intra-grain transport properties. X-ray diffraction study confirmed that all our NdFeAs(O,F) films are epitaxially grown on the MgO bicrystals. The theta_GB dependence of the inter-grain critical current density Jc shows that, unlike Co-doped BaFe2As2 and Fe(Se,Te), its decay with theta_GB is rather significant. As a possible reason of this result, fluorine may have diffused preferentially to the grain boundary region and eroded the crystal structure.
Generation and transfer of single photons on a photonic crystal chip (2007)

We present a basic building block of a quantum network consisting of a quantum dot coupled to a source cavity, which in turn is coupled to a target cavity via a waveguide. The single photon emission from the high-Q/V source cavity is characterized by twelve-fold spontaneous emission (SE) rate enhancement, SE coupling efficiency beta ~ 0.98 into the source cavity mode, and mean wavepacket indistinguishability of ~67%. Single photons are efficiently transferred into the target cavity via the waveguide, with a target/source field intensity ratio of 0.12 +/- 0.01. This system shows great promise as a building block of future on-chip quantum information processing systems.
Reinforcement Learning Based Mobility Load Balancing with the Cell Individual Offset (2021)

In this study, we focus on the cell individual offset (CIO) parameter in the handover process, which represents the willingness of a cell to admit the incoming handovers. However, it is challenging to tune the CIO parameter, as any poor implementation can lead to undesired outcomes, such as making the neighboring cells over-loaded while decreasing the traffic load of the cell. In this work, a reinforcement learning-based approach for parameter selection is introduced, since it is quite convenient for dynamically changing environments. In that regard, two different techniques, namely Q-learning and SARSA, are proposed, as they are known for their multi-objective optimization capabilities. Moreover, fixed CIO values are used as a benchmark for the proposed methods for comparison purposes. Results reveal that the reinforcement learning assisted mobility load balancing (MLB) approach can alleviate the burden on the overloaded cells while keeping the neighboring cells at some reasonable load levels. The proposed methods outperform the fixed-parameter solution in terms of the given metric.
Thermal Injury to Reconstructed Breasts from Commonly Used Warming Devices: A Risk for Reconstructive Failure (2016)

Reconstructed breasts are at risk for injury from commonly used household warming devices and ambient heat from the sun. As a result, patients should be counseled about these risks accordingly, to avoid injury or loss of reconstruction. These injuries require immediate vigilant treatment.