gebhart/patrepeval huggingface dataset:
Changes in either Cytosolic or Nucleoplasmic Inositol 1,4,5-Trisphosphate Levels Can Control Nuclear Ca2+ Concentration (1995)

The free nucleoplasmic Ca2+ concentration ([Ca2+]n) may regulate many nuclear events, such as gene transcription. Since the nucleus may possess the enzymes necessary to generate the second messenger inositol 1,4,5-trisphosphate (Ins(1,4,5)P3), and because the nuclear envelope may enclose an Ins(1,4,5)P3-releasable Ca2+ store, we tested the hypothesis that nuclear and/or cytosolic levels of Ins(1,4,5)P3 can control [Ca2+]n. To assay [Ca2+]n, we measured the fluorescence of the Ca2+ indicator fluo 3 in the nucleus of Xenopus oocytes by confocal microscopy. When we injected Ins(1,4,5)P3 into the cytosol, [Ca2+]n increased. This increase in [Ca2]n still occurred when heparin was present in the nucleus, but was abolished when heparin was present in the cytosol, indicating that cytosolic Ins(1,4,5)P3 levels could control [Ca2+]n. When we injected Ins(1,4,5)P3 directly into the nucleus, [Ca2+]n increased, even when heparin was present in the cytosol, indicating that Ins(1,4,5)P3 could control [Ca2+]n from within the nucleus. These results provide functional evidence for Ins(1,4,5)P3 receptors facing the nucleoplasm and raise the possibility that a phosphoinositide cycle situated at the nuclear membranes can control Ca(2+)-dependent nuclear functions.
Lattice thermodynamics for binary closed‐loop equilibria: Ordinary and polymer systems (1993)

Abstract The incompressible lattice‐gas model by ten Brinke and Karasz is adopted to introduce the effect of specific interactions into a recently‐presented Monte‐Carlobased lattice expression for the Helmholtz energy of nonrandom mixing. While the lattice remains incompressible, intermolecular forces consist of two types: London dispersion forces and specific (chemical) forces. The specific interactions between similar components, as well as those between dissimilar components, are incorporated in a systematic manner. Closed‐loop temperature‐composition phase diagrams are obtained. The theory is compared with experimental data for several binary systems, including polymer solutions, which exhibit closed‐loop coexistence curves. Theoretical and experimental results are in good agreement.
Expression of macrophage inflammatory protein-3α, stromal cell–derived factor-1, and B-cell–attracting chemokine-1 identifies the tonsil crypt as an attractive site for B cells (2001)

The expression of 3 lymphoid chemokines-macrophage inflammatory protein-3alpha (MIP-3alpha), stromal cell-derived factor-1 (SDF-1), and B-cell-attracting chemokine-1 (BCA-1)-in the tonsil and the possible correlation between their sites of expression and B-cell localization within this tissue were studied. The results show that all 3 chemokines are produced in the crypts but differ by the nature of the cells that produce them and their location within the crypt. SDF-1 and MIP-3alpha are produced by epithelial cells, but their secretion is mutually exclusive. Both MIP-3alpha- and SDF-1-expressing cells are in close contact with memory B cells. By contrast, BCA-1-producing cells in the crypt are not epithelial and form clusters colocalized with plasma cells. Altogether, these data suggest that the chemokines produced in the tonsillar crypt may (1) attract memory B cells to antigen and (2) recruit and retain plasma cells and memory B cells within the supportive epithelial microenvironment of the crypt. (Blood. 2001;97:3992-3994)
ChemInform Abstract: Stereoselectivity in Fragmentation and Rearrangement of α‐ Hydroxyiminophosphinates and ‐phosphonates. A Synthetic Approach to Acylphosphon‐ and ‐phosphor‐amidates. Crystal Structures of Methyl (E)‐ α‐Hydroxyiminobenzylphenylphosphinate and Methyl Benzoylphenylphosphonamidate. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Isolated Redox Centers within Microporous Environments. Part 2. Vanadium‐Containing Aluminophosphate Molecular Sieve Five. (1990)

Abstract Vanadium‐containing aluminophosphate five (VAPO‐5) is synthesized by heating a gel of composition Pr 3 N·Al 2 O 3 ·0.95 P 2 O 5 ·0.05 V 2 O 5 ·40 H 2 O to 150 °C at autogeneous pressure (more than 4 h).
Supplementary Video S6 from MAP9 Loss Triggers Chromosomal Instability, Initiates Colorectal Tumorigenesis, and Is Associated with Poor Survival of Patients with Colorectal Cancer (2023)

&lt;p&gt;Supplementary Video S6&lt;/p&gt;
Workflow to build a continuous static elastic moduli profile from the drilling data using artificial intelligence techniques (2021)

Abstract Rock mechanical properties play a crucial role in fracturing design, wellbore stability and in situ stresses estimation. Conventionally, there are two ways to estimate Young’s modulus, either by conducting compressional tests on core plug samples or by calculating it from well log parameters. The first method is costly, time-consuming and does not provide a continuous profile. In contrast, the second method provides a continuous profile, however, it requires the availability of acoustic velocities and usually gives estimations that differ from the experimental ones. In this paper, a different approach is proposed based on the drilling operational data such as weight on bit and penetration rate. To investigate this approach, two machine learning techniques were used, artificial neural network (ANN) and support vector machine (SVM). A total of 2288 data points were employed to develop the model, while another 1667 hidden data points were used later to validate the built models. These data cover different types of formations carbonate, sandstone and shale. The two methods used yielded a good match between the measured and predicted Young’s modulus with correlation coefficients above 0.90, and average absolute percentage errors were less than 15%. For instance, the correlation coefficients for ANN ranged between 0.92 and 0.97 for the training and testing data, respectively. A new empirical correlation was developed based on the optimized ANN model that can be used with different datasets. According to these results, the estimation of elastic moduli from drilling parameters is promising and this approach could be investigated for other rock mechanical parameters.
Optimal circuit design for low power CMOS GSI (2002)

For a prescribed system performance, device, circuit and system design of a static CMOS datapath are conjointly optimized for different operating temperature ranges. Total power dissipation is reduced to one-third the value projected for 0.25 micron CMOS by the National Technology Roadmap for Semiconductors for a single datapath and to less than one-fourteenth the value projected for parallel datapaths assuming operation over a temperature range of 60/spl deg/K above room temperature.
ChiC Gene Enhances Fungal Resistance in Indigenous Potato Variety (Diamant) Via Agrobacterium-Mediated Transformation (2016)

Potato (Solanum tuberosum), one of the indispensable food crops, is susceptible to various fungal phyto-pathogenic infections that result in considerable production losses both in terms of quality and quantity. Developing fungal-resistant cultivars by introducing pathogen-resistant genes through transgenic approach has been a powerful tool to provide defense against the fungal pathogens. The current study was undertaken to develop a fungal resistant trait in a local potato variety. To achieve this goal, a local Pakistani Potato variety (Diamant), was transformed with chitinase ChiC gene utilizing plasmid pEKB/ChiC using Agrobacterium tumefaciens strain EHA101. The infected explants were grown on MS medium supplemented with 2 mg/l BAP and 0.2 mg/l NAA. Explants were then sub-cultured on MS medium supplemented with 2mg/l BAP and 2mg/l GA3 for shooting. PCR examination confirmed the integration of ChiC gene in the potato genomic DNA. The transformed potato variety could also be used as fungus-resistant breeding material and offers new opportunities to develop improved potato cultivars for different agronomic and other desirable traits.
History of Extracardiac/Cardiac Events in Cardiac Amyloidosis: Prevalence and Time from Initial Onset to Diagnosis (2021)

This study highlights the impact of amyloidosis type and evolution on diagnostic delay and on prognosis. Physicians must be aware and vigilant in front of extracardiac and cardiac events to considerably improve early diagnosis of amyloidosis.
Carrier redistribution between different potential sites in semipolar (202¯1) InGaN quantum wells studied by near-field photoluminescence (2014)

Scanning near-field photoluminescence (PL) spectroscopy at different excitation powers was applied to study nanoscale properties of carrier localization and recombination in semipolar (202¯1) InGaN quantum wells (QWs) emitting in violet, blue, and green-yellow spectral regions. With increased excitation power, an untypical PL peak energy shift to lower energies was observed. The shift was attributed to carrier density dependent carrier redistribution between nm-scale sites of different potentials. Near-field PL scans showed that in (202¯1) QWs the in-plane carrier diffusion is modest, and the recombination properties are uniform, which is advantageous for photonic applications.
Personalized imaging: moving closer to reality (2011)

The availability of web and on-line image sharing services makes image personalization and customization a more interesting topic. Nonetheless, designing a personalized image is a time-consuming task, requiring hours of work by expert designers. Observing the potential opportunity to make the design process easier and more amenable to ordinary users, we presented a semi-automatic tool for designing personalized images in the Electronic Imaging (EI) symposium last year.1, 2 As a follow-up, we present several improvements to the original semi-automatic tool, for both text insertion and text replacement on planar surfaces. We also describe our effort in implementing the tool as a true web-based service, which eliminates the need for installation of any software or packages by the user. We believe that we have made the technology of image personalization more friendly and accessible to ordinary users.
Unit Mass Resolution (2016)

This document contains recommendations for terminology in mass spectrometry. Development of standard terms dates back to 1974 when the IUPAC Commission on Analytical Nomenclature issued recommendations on mass spectrometry terms and definitions. In 1978, the IUPAC Commission on Molecular Structure and Spectroscopy updated and extended the recommendations and made further recommendations regarding symbols, acronyms, and abbreviations. The IUPAC Physical Chemistry Division Commission on Molecular Structure and Spectroscopy’s Subcommittee on Mass Spectroscopy revised the recommended terms in 1991 and appended terms relating to vacuum technology. Some additional terms related to tandem mass spectrometry were added in 1993 and accelerator mass spectrometry in 1994. Owing to the rapid expansion of the field in the intervening years, particularly in mass spectrometry of biomolecules, a further revision of the recommendations has become necessary. This document contains a comprehensive revision of mass spectrometry terminology that represents the current consensus of the mass spectrometry community.
Medical DNA Sequencing in Neuroscience (2013)

The decrease in sequencing cost and improvements in throughput as well as analytical methods for data processing and management have made it possible to proceed from sequencing solely as a tool for discovery of genes causing Mendelian forms of disorder to large-scale studies for the identification of low-frequency variants conferring susceptibility to complex disorders. Although current successes are mostly focused on identification of highly penetrant loss-of-function genetic variants causing monogenic forms of complex disorders, this will change when sequencing of sample sizes comparable with those used in genome-wide association studies becomes feasible. This chapter focuses on current technologies available for sequencing studies and offers an overview of study designs. Examples of how these study designs have been combined with available analysis methods to identify genes underlying neurological and neuropsychiatric phenotypes are presented. Current and future challenges of application to these methods in the research and clinical setting are also discussed.
Author Correction: PERK participates in cardiac valve development via fatty acid oxidation and endocardial-mesenchymal transformation (2021)

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Non-audiofacial morbidity after Gamma Knife surgery for vestibular schwannoma. (2013)

OBJECT: While many studies have been published outlining morbidity following radiosurgical treatment of vestibular schwannomas, significant interpractitioner and institutional variability still exists. For this reason, the authors conducted a systematic review of the literature for non-audiofacial-related morbidity after the treatment of vestibular schwannoma with radiosurgery. METHODS: The authors performed a comprehensive search of the English-language literature to identify studies that published outcome data of patients undergoing radiosurgery treatment for vestibular schwannomas. In total, 254 articles were found that described more than 50,000 patients and were analyzed for satisfying the authors' inclusion criteria. Patients from these studies were then separated into 2 cohorts based on the marginal dose of radiation: ≤ 13 Gy and > 13 Gy. All tumors included in this study were 13 Gy were significantly more likely to develop trigeminal nerve neuropathy than those receiving 13 Gy appeared to have a higher rate of symptomatic hydrocephalus requiring shunt treatment (96% [> 13 Gy] vs 56% [≤ 13 Gy], p 13 Gy] vs 1.8% [≤ 13 Gy], p = 0.001) and tinnitus (0.1% [> 13 Gy] vs 0.7% [≤ 13 Gy], p = 0.001) were significantly higher in the lower dose cohort than those in the higher dose cohort. CONCLUSIONS: The results of our review of the literature provide a systematic summary of the published rates of nonaudiofacial morbidity following radiosurgery for vestibular schwannoma.
Data Augmentation for Robust Keyword Spotting under Playback Interference (2018)

Accurate on-device keyword spotting (KWS) with low false accept and false reject rate is crucial to customer experience for far-field voice control of conversational agents. It is particularly challenging to maintain low false reject rate in real world conditions where there is (a) ambient noise from external sources such as TV, household appliances, or other speech that is not directed at the device (b) imperfect cancellation of the audio playback from the device, resulting in residual echo, after being processed by the Acoustic Echo Cancellation (AEC) system. In this paper, we propose a data augmentation strategy to improve keyword spotting performance under these challenging conditions. The training set audio is artificially corrupted by mixing in music and TV/movie audio, at different signal to interference ratios. Our results show that we get around 30-45% relative reduction in false reject rates, at a range of false alarm rates, under audio playback from such devices.
Directionality assessment of adaptive binaural beamforming with noise suppression in hearing aids (2015)

In this work we present a new method for assessment of directionality in modern hearing aids, which has the benefit of simulating both a target source and an interfering source at the same time using speech signals. We show the benefits and the limitations of the method and present measurements for different microphone modes of different manufacturers. Furthermore, a sequential index based on these measurements is introduced.
Serum Periostin Level Has Limited Usefulness as a Biomarker for Allergic Disease in 7-Year-Old Children (2019)

Our results suggest thatserum periostin level may have limited usefulness as a biomarker of allergic disease in children.
The infarcted myocardium solicits GM-CSF for the detrimental oversupply of inflammatory leukocytes (2017)

Myocardial infarction (MI) elicits massive inflammatory leukocyte recruitment to the heart. Here, we hypothesized that excessive leukocyte invasion leads to heart failure and death during acute myocardial ischemia. We found that shortly and transiently after onset of ischemia, human and mouse cardiac fibroblasts produce granulocyte/macrophage colony-stimulating factor (GM-CSF) that acts locally and distally to generate and recruit inflammatory and proteolytic cells. In the heart, fibroblast-derived GM-CSF alerts its neighboring myeloid cells to attract neutrophils and monocytes. The growth factor also reaches the bone marrow, where it stimulates a distinct myeloid-biased progenitor subset. Consequently, hearts of mice deficient in either GM-CSF or its receptor recruit fewer leukocytes and function relatively well, whereas mice producing GM-CSF can succumb from left ventricular rupture, a complication mitigated by anti-GM-CSF therapy. These results identify GM-CSF as both a key contributor to the pathogenesis of MI and a potential therapeutic target, bolstering the idea that GM-CSF is a major orchestrator of the leukocyte supply chain during inflammation.
"Praenestini" en "Aquileia": movilidad de "gentes" y cultos en época republicana (2013)

La difusión de nuevos cultos fue un fenómeno parejo al proceso de colonización de la Galia Cisalpina, manifestándose en las primeras fundaciones coloniales de los siglos III y II a.C. En la deducción que se produjo en Aquileia en el año 181 a.C. y en el suplemento acaecido en el 169 a.C., participaron como colonos miembros de familias romanas, latinas e itálicas tanto de procedencia peninsular como cisalpina. Generalmente se acepta que la mayor parte de estos colonos presentaba unos orígenes centro-itálicos. En este artículo nos centraremos en las familias de origen prenestino que llegaron a Aquileia y especialmente en las prácticas religiosas que éstas trajeron consigo.
Neutral transport during etching of high aspect ratio features (2023)

This paper studies the transport of neutral etch species in cylindrical holes, which are of interest for advanced memory devices. The etching of these devices utilizes ions and neutral reactive species, which must travel to the etch front deep inside the feature. For gas pressures in the millitorr and feature sizes in the nanometer range, neutrals reach the bottom of an etching feature via the Knudsen transport1,2. For an aspect ratio of depth to diameter of 100:1, the flux at the bottom of the feature is only 1.3% of the incoming flux. This is a challenge for etching of advanced memory devices with ever increasing aspect ratios. We present computational results for the neutral transport in high aspect ratio features as a function of aspect ratio, profile shape, and surface processes such as adsorption, desorption, and diffusion of neutral species. Pertinent parameters are varied over a wide range to identify salient trends. When available, we include values for the case of fluorine radicals on silicon and silicon oxide in the parameter scans. The results predict that steady state transmission probability increases meaningfully in the presence of surface diffusion. Spontaneous and collision induced desorption of adsorbed neutrals on their own does not change steady state transmission probability, but they affect the time to reach it. In the presence of surface diffusion, however, spontaneous desorption increases the transmission probability, while desorption due to collisions with co-flowing nonreactive gas reduces it. These results indicate an enhancement of neutral transport at low surface temperatures that facilitate physisorption and surface diffusion.
Application of Nanotechnology in Anti-Counterfeiting Packaging (2013)

The necessity of anti-counterfeiting packaging and the concept of nanometer anti-counterfeiting technology to explore the application of nanotechnology in the anti-counterfeiting packaging have been briefly described in this paper. The advantages and disadvantages of nanotechnology in anti-counterfeiting material, in anti-counterfeiting inks, in information encryption are compared by analyzing the principles, characteristic and typical cases. In the end, summarizing the superiority and the issues should be resolved in the application of nanotechnology in anti-counterfeiting packaging to show the prospects.
Feasibility concerns in PGM graphs with bounded buffers (2002)

The Processing Graph Method (PGM)-a dataflow model widely used in the design and analysis of embedded signal-processing applications-is studied from a real-time scheduling perspective. It is shown that the problem of deciding if instances of the general model are feasible on a single processor is intractable (co-NP-complete in the strong sense); however, a useful special case is sometimes more tractable. An efficient feasibility test and an optimal preemptive scheduling algorithm are derived for this special case, and a procedure is presented which permits system architects to make efficient use of computational resources and memory requirements for buffers while constructing real-time dataflow applications that offer hard service guarantees.
Secure Education and Learning Research at Scale with OpenStax Kinetic (2023)

OpenStax Kinetic is an innovative research infrastructure that aims to transform education and learning research in the digital age. With its access to large sample sizes, authentic learning environments, experimental control, scalability, security and privacy protection, Kinetic provides an unparalleled opportunity for researchers to study the complex interactions between different factors in digital learning environments. This versatile platform utilizes Qualtrics and can support various research designs, including correlational, longitudinal, and interventional studies. Kinetic's unique privacy-by-design implementation via secure enclaves ensures that researchers can analyze fully-identified data without compromising data security and privacy as well as affords greater analytical reproducibility. The findings from Kinetic can inform educational interventions and strategies to enhance student success in digital learning environments. Kinetic has the potential to significantly advance education and learning research by improving pedagogies, practices, and policies in education and learning sciences. In this demo of Kinetic, researchers will be able to interact with the test instance of the Kinetic system online and view the learner experience. All researchers will be able to engage in the experience of creating a study, releasing a study, and interacting with our implementation of secure enclaves for data analysis.
Supplementary Data from Loss and Reduction of Fus1 Protein Expression is a Frequent Phenomenon in the Pathogenesis of Lung Cancer (2023)

Supplementary Data from Loss and Reduction of Fus1 Protein Expression is a Frequent Phenomenon in the Pathogenesis of Lung Cancer
In Vivo Delivery of a DNA-Encoded Monoclonal Antibody Protects Non-human Primates against Zika Virus (2019)

Zika virus (ZIKV) infection is endemic to several world regions, and many others are at high risk for seasonal outbreaks. Synthetic DNA-encoded monoclonal antibody (DMAb) is an approach that enables in vivo delivery of highly potent mAbs to control infections. We engineered DMAb-ZK190, encoding the mAb ZK190 neutralizing antibody, which targets the ZIKV E protein DIII domain. In vivo-delivered DMAb-ZK190 achieved expression levels persisting >10 weeks in mice and >3 weeks in non-human primate (NHPs), which is protective against ZIKV infectious challenge. This study is the first demonstration of infectious disease control in NHPs following in vivo delivery of a nucleic acid-encoded antibody, supporting the importance of this new platform.