gebhart/patrepeval huggingface dataset:
Statin Therapy Is Associated with Decreased Small, Dense Low-Density Lipoprotein Levels in Patients Undergoing Peritoneal Dialysis (2012)

Cardiovascular disease is a major cause of morbidity and mortality among hemodialysis (HD) and peritoneal dialysis (PD) patients, and dyslipidemia plays an important role in its pathogenesis. In particular, small, dense LDL (sd-LDL) particles have been recently highlighted as an emerging cardiovascular risk factor. PD patients exhibit a more overtly abnormal lipid profile than HD patients, probably due to the metabolic interference of the peritoneal dialysis fluid. Statins are the main drugs for the treatment of dyslipidemia and they are able to decrease all LDL subclasses levels, but it remains unclear whether they can influence the proportion of sd-LDL. Only few studies regarding the effect of statins on the proportion of these particles have been performed in HD patients and, to our knowledge, no trials have been carried out in PD patients. Therefore, we compared the lipid profile and the proportion of sd-LDL in two populations of HD and PD patients. Our study suggests that statin therapy may be effective in reducing both the absolute amount and the proportion of sd-LDL in patients with a more overtly abnormal lipid profile, such as patients undergoing peritoneal dialysis. Statins do not seem to be effective in altering sd-LDL levels in patients undergoing hemodialysis with other factors that can influence LDL subtractions generation, such as hypertension and diabetes mellitus. If and when our results prove to be reproducible in large-scale studies, such studies should provide new insights into sd-LDL and its actual role in atherogenesis in patients undergoing hemodialysis or peritoneal dialysis.
Which cardiac surgical patients can benefit from placement of a pulmonary artery catheter? (2006)

The use of pulmonary artery catheters (PACs) during cardiac surgery varies considerably depending on local policy, ranging from use in 5-10% of the patient population to routine application. However, as in other clinical fields, recent years have witnessed a progressive decline in PAC use. One of the reasons for this is probably the increasing use of transoesophageal echocardiograpy, even though careful analysis of the information provided by PAC and transoesophageal echocardiograpy indicates that the two tools should be considered subsidiary rather than alternatives. The principal categories of cardiac patients who can benefit from PAC monitoring are those with present and those with possible haemodynamic instability. On this basis we can identify five groups: patients with impaired left ventricular systolic function; those with impaired right ventricular systolic function; those with left ventricular diastolic dysfunction; those with an acute ventricular septal defect; and those with a left ventricular assist device. This review highlights the specific role of PAC-derived haemodynamic data for each category.
Hotspot traffic statistics and throughput models for several applications (2005)

Public wireless local-area networks (PWLANs) based on IEEE 802.11a/b/g standards are growing rapidly. Thus, it is critical to understand aggregated traffic statistics and network performance at and around PWLAN service areas. The paper presents measured PWLAN traffic statistics and application-level throughput at four hotspots that provide free Internet access. The four hotspots, located in Austin, Texas and owned by Schlotzsky's Inc., a national restaurant chain, used standard IEEE 802.11b equipment. This measurement campaign provided approximately 16 million PWLAN packets and several hundred throughput and SNR measurements. Throughput prediction models are developed based upon the measured data. These analysis results and throughput prediction models may facilitate the design and development of IEEE 802.11e/n standards and implementations. Moreover, the results provide insights into the required provisioning for PWLANs and autonomous control approaches for future broadband wireless access and real-time wireless voice/video services, especially when site-specific information is available.
759-P: Analysis of a Two-Year Continuous Care Intervention Including Nutritional Ketosis—Exploring Baseline Predictors of Diabetes Reversal and Remission (2019)

Background: We recently reported 55% of the patients reversed type 2 diabetes in the continuous care intervention (CCI) while 18% of the patients achieved remission at 2 years. In this post hoc analysis, factors identified in previous studies as predictors of diabetes reversal and remission were examined. Methods: Baseline factors including diabetes duration, HbA1c, fasting glucose and a composite index (HbA1c, fasting insulin and ALT1) were examined as potential predictors of T2D reversal and remission in the CCI group along with percentage weight loss over the study period. Spearman correlation was used to assess relationships between predictors and 2 years reversal and remission. Factors with significant correlation were analyzed using logistic regression. Results: Diabetes duration, baseline HbA1c, fasting glucose and the composite index were significantly correlated with diabetes reversal and remission (Table 1). Logistic regression analyses showed that diabetes duration (OR=1.2, p=7.0x10-6) and baseline HbA1c (OR=1.5, p=0.003) were associated with diabetes reversal at 2 years whereas weight loss percentage during the study period was not. Conclusion: Shorter diabetes duration and lower baseline HbA1c are two factors strongly related to achieving diabetes reversal and remission in CCI participants at 2 years. Disclosure S.J. Athinarayanan: Employee; Self; Virta Health Corp. A. McKenzie: Employee; Self; Virta Health Corp. Stock/Shareholder; Self; Virta Health Corp. R.N. Adams: Employee; Self; Virta Health Corp. S. Hallberg: Advisory Panel; Self; Atkins Nutritionals, Inc. Employee; Self; Virta Health Corp. Stock/Shareholder; Self; Virta Health Corp. J.P. McCarter: Employee; Self; Virta Health Corp. S. Phinney: Advisory Panel; Self; Atkins Nutritionals, Inc. Board Member; Self; Virta Health Corp. Employee; Self; Virta Health Corp. Stock/Shareholder; Self; Virta Health Corp. Other Relationship; Self; Beyond Obesity. Funding Virta Health Corp
Micrococcal Nuclease-Southern Blot Assay: I. MNase and Restriction Digestions: Figure 1. (2007)

INTRODUCTIONThis is the first phase of a two-part assay for exploring whether an endogenous control region of interest is assembled into nucleosomes or is devoid of nucleosomes. This assay can also be used to determine if nucleosomes are similarly positioned at the locus in every cell within a population. Micrococcal nuclease (MNase) is unique among nucleases in its relative ability to induce double-strand breaks within nucleosomal linker regions, but only single-stranded nicks within the nucleosome itself. Because of this property, micrococcal nuclease can be used to determine whether a DNA fragment of interest is nucleosomal. In this phase of the assay, the cells are lysed and nuclei are isolated. Limiting concentrations of micrococcal nuclease are added to the nuclei, resulting in cleavage at nucleosome linker regions (preferably cleavage at two sites per DNA molecule). The cleavage reactions are stopped, and then the genomic DNA is purified and digested with restriction enzymes.
Long-Term Survival after Ablation of the Atrioventricular Node and Implantation of a Permanent Pacemaker in Patients with Atrial Fibrillation (2001)

In the absence of underlying heart disease, survival among patients with atrial fibrillation after ablation of the atrioventricular node is similar to expected survival in the general population. Long-term survival is similar for patients with atrial fibrillation, whether they receive ablation or drug therapy. Control of the ventricular rate by ablation of the atrioventricular node and permanent pacing does not adversely affect long-term survival.
Modelling and predicting low count child asthma hospital readmissions using General Additive Models (2013)

Background: Daily paediatric asthma readmissions within 28 days are a good example of a low count time series and not easily amenable to common time series methods used in studies of asthma seasonality and time trends. We sought to model and predict daily trends of childhood asthma readmissions over time inVictoria,Australia. Methods: We used a database of 75,000 childhood asthma admissions from the Department ofHealth,Victoria,Australiain 1997-2009. Daily admissions over time were modeled using a semi parametric Generalized Additive Model (GAM) and by sex and age group. Predictions were also estimated by using these models. Results: N = 2401 asthma readmissions within 28 days occurred during study period. Of these, n = 1358 (57%) were boys. Overall, seasonal peaks occurred in winter (30.5%) followed by autumn (28.6%) and then spring (24.6%) (p p
<title>System for rapid detection and mapping of gas plumes on 100 m scales: examination of some technical and economic issues</title> (1995)

We consider the design of a system combining computed tomography and Fourier Transform Infrared Spectroscopy (CT/FTIR) to detect and map the concentration of multicontaminant gas plumes in ambient air over a 100 m square area. Several factors affecting the accuracy of the reconstructed map and the detection limits that can be achieved in the field are discussed. The estimated cost and capabilities of the system are compared with those of a more conventional gas monitoring system that might operate over a similar spatial extent. The paper includes a description of a proposed system that is designed to produce a map of multiple gaseous contaminants with a resolution of 12 m X 12 m in a time of approximately 10 minutes by sequentially measuring the contaminant concentrations along 48 intersecting beam paths and then reconstructing the map using a CT algorithm adapted to detect Gaussian plumes. The optical elements consist of an FTIR mounted on a steerable telescope platform, a second remote steerable mirror platform, and 32 fixed retro-reflectors.
Repurposing the Ionophore, PBT2, for Treatment of Multidrug-Resistant Neisseria gonorrhoeae Infections (2022)

Multidrug-resistant (MDR) N. gonorrhoeae is a current public health threat. New therapies are urgently needed. PBT2 is an ionophore that disrupts metal homeostasis. PBT2 administered with zinc is shown to reverse resistance to antibiotics in several bacterial pathogens. Here we show that both N. meningitidis and MDR N. gonorrhoeae are sensitive to killing by PBT2 alone. PBT2 is, thus, a candidate therapeutic for MDR N. gonorrhoeae infections.
Off-Resonance Photosensitization of a Photorefractive Polymer Composite Using PbS Nanocrystals (2015)

The photosensitization of photorefractive polymeric composites for operation at 633 nm is accomplished through the inclusion of narrow band gap semiconductor nanocrystals composed of PbS. Unlike previous studies involving photosensitization of photorefractive polymer composites with inorganic nanocrystals, we employ an off-resonance approach where the first excitonic transition associated with the PbS nanocrystals lies at ∼1220 nm and not the wavelength of operation. Using this methodology, internal diffraction efficiencies exceeding 82%, two-beam-coupling gain coefficients of 211 cm–1, and response times of 34 ms have been observed, representing some of the best figures of merit reported for this class of materials. These data demonstrate the ability of semiconductor nanocrystals to compete effectively with traditional organic photosensitizers. In addition to superior performance, this approach also offers an inexpensive and easy means by which to photosensitize composite materials. The photoconductive characteristics of the composites used for this study will also be considered.
HIV-1 interacts with human testicular germ cells in vitro (2013)

International audience
The Sooner City Project: A 5 Year Update (2020)

The Sooner City project at the University of Oklahoma (OU) seeks to reform the traditional civil engineering curriculum by including design projects at every level of the curriculum, not simply as a senior capstone project. The project can be implemented without changing the traditional course sequencing, which enhances faculty buy-in. It is part of a larger movement to reform engineering education by teaching students to: contribute in a dynamic, team-oriented professional environment, use advanced critical thinking skills, use computers proficiently, and communicate effectively to other engineers and to the public. Sooner City is in its 5 th year at the OU School of Civil Engineering and Environmental Science (CEES). Five CEES classes per semester, freshman through senior, have incorporated design projects for a virtual city. Projects have ranged from concrete footings for virtual office buildings to floodplain analysis and bridge crossing design. This paper presents key results from two important tools used to evaluate the success of the Sooner City project: questionnaires completed every
Anna Siewierska, Functional Grammar. (Linguistic Theory Guides.) London & New York: Routledge, 1991. Pp. xxi + 279. (1992)

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Regioselective incorporation of CO into enamines by rhodium-catalyzed reaction with a hydrosilane and CO (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRegioselective incorporation of CO into enamines by rhodium-catalyzed reaction with a hydrosilane and COShinichi Ikeda, Naoto Chatani, Yasuteru Kajikawa, Kouichi Ohe, and Shinji MuraiCite this: J. Org. Chem. 1992, 57, 1, 2–4Publication Date (Print):January 1, 1992Publication History Published online1 May 2002Published inissue 1 January 1992https://pubs.acs.org/doi/10.1021/jo00027a002https://doi.org/10.1021/jo00027a002research-articleACS PublicationsRequest reuse permissionsArticle Views306Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Ultrafast Nonlinear Optics and Mid-IR Frequency Comb Generation With Mode-Locked Cr:ZnS lasers (2022)

Ultrafast lasers based on Cr 2+ -doped II-VI semiconductors provide a convenient way to generate optical frequency combs in a broad spectral range. We will give an overview of Cr 2+ - based femtosecond sources and their applications in dual-comb spectroscopy.
Quantification of white matter and gray matter volumes from three‐dimensional magnetic resonance volume studies using fuzzy classifiers (1998)

We accurately measured white matter (WM) and gray matter (GM) from three-dimensional (3D) volume studies, using a fuzzy classification technique. The new segmentation method is a modification of a recently published method developed for T1 parametric images. 3D MR images were transformed into pseudo forms of T1 parametric images and segmented into WM and GM voxel fraction images with a set of standardized fuzzy classifiers. This segmentation method was validated with synthesized 3D MR images as phantoms. These phantoms were developed from cryosectioned human brain images located in the superior, middle, and inferior regions of the cerebrum. Phantom volume measurements revealed that, generally, the difference between measured and actual volumes was less than 3% for 1.5-mm simulated brain slices. The average cerebral GM/WM ratio calculated from 3D MR studies in four subjects was 1.77, which compared favorably with the estimate of 1.67 derived from anatomical data. Results indicate that this is an accurate and rapid method for quantifying WM and GM from Tl-weighted 3D volume studies.
Posttranslational modifications in the biosynthesis of type IV collagen by a human tumor cell line (1981)

Factors responsible for the high extent of intracellular posttranslational modifications in type IV collagens were studied in a cultured human tumor cell line, HT-1080. These cells do not synthesize any detectable amounts of interstitial collagens but produce type IV collagen at a high rate, corresponding to about one-third of the production of interstitial collagens by cultured human skin fibroblasts. Prolyl 4-hydroxylase activity was lower in the HT-1080 cells than in human skin fibroblasts, there being a rough correlation between this enzyme activity and the rate of 4-hydroxyproline formation in these two cell types. The differing extents of the respective modifications could largely be explained by differences in the activities of lysyl hydroxylase and the hydroxylysyl glycosyltransferases between the two cell types. No difference ws found in prolyl 3-hydroxylase activity, however, even though the extent of 3-hydroxylation of proline residues was about 6-fold in the type IV collagens. In experiments where the HT-1080 cells were studied in suspension, a lag of about 100 min was found before the secretion of type IV collagen from the cells became linear. Pulse-chase experiments in suspension indicated that all the intracellular enzyme reactions proceeded for about 40 min, presumably due to the slow triple-helix formation in type IV collagens. This slow helix formation apparently contributed to the high extent of all the intracellular modifications but was not a major factor.
A Millimeter-Wave ADPLL With Reference Oversampling and Third-Harmonic Extraction Featuring High FoMjitter-N (2021)

This letter proposes a mm-wave fractional-N reference-oversampling (ROS) ADPLL for 5G applications utilizing a relatively low but standard reference frequency. The 4× ROS phase detector (PD) increases the phase detection rate 4× in a power-efficient manner in order to reduce the in-band phase noise contributed from the PD. This improves the overall FoM and locking speed. A class-F3 oscillator generates both 10 GHz and its third harmonic. The former is fed to the feedback divider, while the latter is extracted to generate the 30 GHz output. The fractional phase and reference distortions are compensated in digital with the assistance of DACs. The proposed ROS-ADPLL is implemented in 28-nm CMOS. Using a standard 50 MHz reference frequency, it achieves 237 fs rms jitter while consuming only 11.9 mW, achieving best-in-class FoMjitter-N of –269.3 dB.
Absorption and fluorescence spectroscopy of a nanodusty plasma (2018)

Nanoparticles can be easily produced in typical low-pressure plasmas, either by injecting reactive gases or by sputtering materials deposited on the electrodes. In these cases, a dense nanoparticle cloud is obtained and fills most of the plasma volume. As nanoparticles attach plasma free electrons, a huge nanoparticle density induces a strong disturbance of the plasma properties and stability. It can give rise to a wide variety of low-frequency instabilities and to the appearance of a void region, usually located in the plasma center, and characterized by an enhanced light emission.
In this contribution, laser absorption and laser induced fluorescence are used to evidence the effects of nanoparticle growth on argon metastable atoms. These non-intrusive laser techniques have recently shown their ability to reveal the strong plasma modification as nanoparticles are grown thanks to acetylene addition. In the present work, nanoparticles are grown from the sputtering of a carbonaceous layer deposited on the electrodes. The obtained dense nanoparticle cloud can be easily observed with laser light scattering. Absorption and fluorescence profiles are analyzed with a particular attention on spatially dependent effects related to void formation and nanoparticle cloud instabilities.
Knockout of A3 adenosine receptors reduces mouse intraocular pressure. (2002)

The reduced IOP and altered purinergic responses of IOP in A3AR knockout mice support the conclusion that A3ARs contribute to the regulation of IOP.
ABC BCD Polymerization:  A Self-Condensing Vinyl and Cyclic Ester Polymerization by Combination Free-Radical and Ring-Opening Techniques (1999)

The sequential and concurrent polymerizations of an ABC monomer (γ-(ε-caprolactone) 2-bromo-2-dimethylpropionate) with a BCD monomer (2-hydroxyethyl methacrylate) are introduced. This novel polymerization method is a versatile concept to branched copolymers. The two monomers that polymerize by different chemistries, ring-opening polymerization (ROP) and atom transfer radical polymerization (ATRP), bear initiating centers that are for the type of chemistry that is on the opposite monomer. In this way, a branched copolymer is realized without going through a traditional multistep procedure. The branching density can be altered simply by the addition of the appropriate AB (ε-caprolactone) and/or CD (methyl methacrylate) monomers.
Liquid crystalline dendrimers (2007)

In recent years, there has been an increasing interest in the field of liquid crystalline dendrimers. Such a fast development is, among other things, driven by the multiple possibilities offered by combining the mesomorphic properties of single mesogenic subunits with the supermolecular and versatile architectures of dendrimers to yield a new class of highly functional materials. The induction and the control of the mesomorphic properties (phase type and stability) in dendrimers can be achieved by a dedicated molecular design which depends on the chemical nature and structure of both the functional groups and the dendritic matrix. In particular, the intrinsic connectivity of the dendrimer such as the multivalency of the focal core and the multiplicity of the branches, both controlling the geometrical rate of growth, or the dendritic generation, plays a crucial role and influences at various stages the subtle relationships between the supermolecular structure and the mesophase structure and stability. In this critical review article, an account of the various types of dendritic systems that form liquid-crystalline mesophases along with a description of the self-organization of representative case-study supermolecules into liquid crystalline mesophases will be discussed. Some basics of thermotropic liquid crystals and dendrimers will be given in the introduction. Then, in the following sections, selected examples including side-chain, main-chain, fullerodendrimers, shape-persistent dendrimers, supramolecular dendromesogens and metallodendrimers, as representative families of LC dendrimers, will be described. In the conclusion some further developments will be highlighted. This review will not cover liquid crystalline hyperbranched and dendronized polymers that might be considered as being somehow less structurally "perfect".
Europium Cryptate Labeled Deoxyuridine-Triphosphate Analog: Synthesis and Enzymatic Incorporation (2000)

The synthesis of an europium tris-bipyridine cryptate labeled 2'-deoxyuridine-5 '-triphosphate analog (K-11-dUTP) is described. This labeled triphosphate was incorporated into DNA through enzymatic reactions with terminal transferase and DNA polymerases. The enzymatic reactions were monitored by TRACE (Time Resolved Amplification of Cryptate Emission), a homogeneous method using Fluorescence Resonance Energy Transfer (FRET) from an europium cryptate as donor to a modified allophycocyanine as acceptor.