gebhart/patrepeval huggingface dataset:
Adult Urology Focal Cryosurgery: Encouraging Health Outcomes for Unifocal Prostate Cancer (2007)

The median age was 68 years (range 48 to 78). The median preoperative PSA level was 6.0 ng/mL, and the postoperative PSA nadir was 2.4 ng/mL. The median follow-up was 28 months. Seventeen patients remained potent. No patients reported worsened lower urinary tract symptoms, incontinence, rectal pain, perineal discomfort, or fistula formation. The median PSA nadir was 2.4 ng/mL, and 40% of patients had a PSA nadir of less than 1.0 ng/mL. Of the 25 patients, 21 (84%) had not experienced biochemical failure, defined as a greater than 50% PSA nadir reduction. Seven patients underwent repeat biopsy, and prostate cancer was detected in the contralateral gland in 2 patients and in the area of previous cryosurgery in 1 patient. CONCLUSIONS Focal cryoablation of the prostate has exhibited minimal morbidity and promising efficacy in our 3-year observation. Longer follow-up is necessary to determine its role in the treatment of patients with low-risk unifocal prostate cancer. UROLOGY 69: 1117‐1120, 2007. © 2007 Elsevier Inc.
Lead-related quantum emitters in diamond (2019)

We report on quantum emission from Pb-related color centers in diamond following ion implantation and high-temperature vacuum annealing. First-principles calculations predict a negatively charged Pb-vacancy (PbV) center in a split-vacancy configuration, with a zero-phonon transition around 2.4 eV. Cryogenic photoluminescence measurements performed on emitters in nanofabricated pillars reveal several transitions, including a prominent doublet near 520 nm. The splitting of this doublet, 5.7 THz, exceeds that reported for other group-IV centers. These observations are consistent with the PbV center, which is expected to have a combination of narrow optical transitions and stable spin states, making it a promising system for quantum network nodes.
Latency Reduction in Vehicular Sensing Applications by Dynamic 5G User Plane Function Allocation with Session Continuity (2021)

Vehicle automation is driving the integration of advanced sensors and new applications that demand high-quality information, such as collaborative sensing for enhanced situational awareness. In this work, we considered a vehicular sensing scenario supported by 5G communications, in which vehicle sensor data need to be sent to edge computing resources with stringent latency constraints. To ensure low latency with the resources available, we propose an optimization framework that deploys User Plane Functions (UPFs) dynamically at the edge to minimize the number of network hops between the vehicles and them. The proposed framework relies on a practical Software-Defined-Networking (SDN)-based mechanism that allows seamless re-assignment of vehicles to UPFs while maintaining session and service continuity. We propose and evaluate different UPF allocation algorithms that reduce communications latency compared to static, random, and centralized deployment baselines. Our results demonstrated that the dynamic allocation of UPFs can support latency-critical applications that would be unfeasible otherwise.
Near- and Supercritical Alcohols as Solvents and Surface Modifiers for the Continuous Synthesis of Cerium Oxide Nanoparticles (2012)

Supercritical fluids offer fast and facile routes toward well-crystallized tailor-made cerium oxide nanoparticles. However, the use of surfactants to control morphology and surface properties remains essential. Therefore, although water, near-critical (nc) or supercritical (sc), is a solvent of choice, the poor water solubility of some surfactants could require other solvent systems such as alcohols, which could themselves behave as surface modifiers. In here, the influence of seven different alcohols, MeOH, EtOH, PrOH, iPrOH, ButOH, PentOH, and HexOH, in alcothermal conditions (300 °C, 24.5 MPa) over CeO(2) nanocrystals (NCs) size, morphology, and surface properties was investigated. The crystallite size of the CeO(2) nanocrystals can be tuned in the range 3-7 nm depending on the considered alcohol, and their surface has been modified by these solvents without the use of surfactants. Mechanisms are proposed for the interaction of primary and secondary alcohols with CeO(2) surface and its functionalization during the synthesis based on FTIR and TGA-MS studies. This study allows apprehending the role of alcohols during the synthesis and may lead to an informed choice of solvent as a function of the required size and surface properties of CeO(2) NCs. It also opens new route to CeO(2) functionalization using supercritical alcohol derivatives.
Synthesis, bulk, surface and microlithographic characterization of poly(1-butene sulfone)-g-poly(dimethylsiloxane) (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis, bulk, surface and microlithographic characterization of poly(1-butene sulfone)-g-poly(dimethylsiloxane)J. M. DeSimone, G. A. York, J. E. McGrath, A. S. Gozdz, and M. J. BowdenCite this: Macromolecules 1991, 24, 19, 5330–5339Publication Date (Print):September 1, 1991Publication History Published online1 May 2002Published inissue 1 September 1991https://doi.org/10.1021/ma00019a019RIGHTS & PERMISSIONSArticle Views243Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (4 MB) Get e-Alertsclose Get e-Alerts
Title OFDM preamble structure analysis and proposal. Date Submitted 03/07/2001 (2001)

OFDM preamble structure analysis and proposal. Abstract This document contains analysis and proposal for the OFDM preamble design for the 802.16ab system. Purpose This proposal should be used for the OFDM preamble design
Data from ARX788, a Site-specific Anti-HER2 Antibody–Drug Conjugate, Demonstrates Potent and Selective Activity in HER2-low and T-DM1–resistant Breast and Gastric Cancers (2023)

&lt;div&gt;Abstract&lt;p&gt;First-generation antibody–drug conjugates (ADC) are heterogeneous mixtures that have shown clinical benefit, but generally exhibited safety issues and a narrow therapeutic window due, in part, to off-target toxicity caused by ADC instability. ARX788 is a next-generation, site-specific anti-HER2 ADC that utilizes a unique nonnatural amino acid–enabled conjugation technology and a noncleavable Amberstatin (AS269) drug-linker to generate a homogeneous ADC with a drug-to-antibody ratio of 1.9. ARX788 exhibits high serum stability in mice and a relatively long ADC half-life of 12.5 days. When compared &lt;i&gt;in vitro&lt;/i&gt; against T-DM1 across a panel of cancer cell lines, ARX788 showed superior activity in the lower HER2-expressing cell lines and no activity in normal cardiomyocyte cells. Similarly, ARX788 significantly inhibited tumor growth, and generally outperformed T-DM1 in HER2-high and HER2-low expression xenograft models. Breast and gastric cancer patient-derived xenograft studies confirmed strong antitumor activity of ARX788 in HER2-positive and HER2-low expression tumors, as well as in a T-DM1-resistant model. The encouraging preclinical data support the further development of ARX788 for treatment of patients with HER2-positive breast and gastric cancer, including those who have developed T-DM1 resistance, and patients with HER2-low expression tumors who are currently ineligible to receive HER2-targeted therapy.&lt;/p&gt;&lt;/div&gt;
Gene–gene interaction of AhRwith and within the Wntcascade affects susceptibility to lung cancer (2022)

The role of variants belonging to Wnt/AhR-pathways in lung cancer susceptibility may be underrated in main-effects association analysis. Complex interaction patterns in individuals of European descent have moderate predictive capacity for lung cancer or subgroups thereof, especially in never smokers.
Copper‐Free Click Reactions with Polar Bicyclononyne Derivatives for Modulation of Cellular Imaging (2014)

The ability of cells to incorporate azidosugars metabolically is a useful tool for extracellular glycan labelling. The exposed azide moiety can covalently react with alkynes, such as bicyclo[6.1.0]nonyne (BCN), by strain-promoted alkyne-azide cycloaddition (SPAAC). However, the use of SPAAC can be hampered by low specificity of the cycloalkyne. In this article we describe the synthesis of more polar BCN derivatives and their properties for selective cellular glycan labelling. The new polar derivatives [amino-BCN, glutarylamino-BCN and bis(hydroxymethyl)-BCN] display reaction rates similar to those of BCN and are less cell-permeable. The labelling specificity in HEK293 cells is greater than that of BCN, as determined by confocal microscopy and flow cytometry. Interestingly, amino-BCN appears to be highly specific for the Golgi apparatus. In addition, the polar BCN derivatives label the N-glycan of the membrane calcium channel TRPV5 in HEK293 cells with significantly enhanced signal-to-noise ratios.
Temperature‐sensitive mutants of murine leukemia virus. V. Impaired leukemogenic activity in vivo (1975)

The in vivo biologic activities of a clonal isolate of the Rauscher strain of murine leukemia virus and several conditional lethal mutants with impaired replicative functions at the non-permissive temperature were investigated. The parental virus induced a rapidly developing lymphoid leukemia in a high percentage of NIH Swiss mice inoculated as newborns. Mice inoculated in parallel with temperature-sensitive mutant viruses showed no evidence of disease. The implications of these findings with regard to the requirements for type-C virus replication to permit oncogenic transformation of lymphoid cells in vivo are discussed.
Free electron density and mobility in high-quality 4H–SiC (2000)

The free electron density and low-field electron mobility of 4H–SiC is examined in the temperature range 35–900 K. In good samples the electron density is constant in the temperature range 300–900 K, which offers interesting possibilities for high temperature sensor applications. On the best sample an experimental electron mobility of 12 400 cm2/V s at 50 K is found. A complete description of the temperature dependence of the electron density and mobility is given. We take into account the effects of the two inequivalent lattice sites as well as the valley–orbit splitting of the ground state at the hexagonal sites. The dependence of room-temperature mobility on electron concentration is established, described theoretically and compared with the results obtained by different authors.
Shear-Induced Layered Structure of Polymeric Micelles by SANS (2007)

Small-angle neutron scattering (SANS), under shear using a Couette cell in radial and tangential scattering geometry, was performed to examine the structural evolution of the polymeric micellar macrolattice formed by concentrated aqueous solutions of triblock copolymerpoly(ethylene oxide)99−poly(propylene oxide)69−poly(ethylene oxide)99 (Pluronic F127)as a function of the shear rate. The micellar gel showed a shear thinning, i.e., a reduction of the resistance to shear, by forming a layered stacking of two-dimensional hexagonally close packed (HCP) polymer micelles. While traditional SANS experiments using a Couette shear cell are performed in radial geometry, we found the use of the tangential scattering geometry essential to obtain information on the layer stacking sequence. A theoretical model was developed to calculate 2D SANS scattering patterns that can be compared with the experimental data. We found that the micellar cores maintained their spherical shapes without deforming into ellipsoids and that the intralayer neighboring micelle center-to-center distance and the interlayer long period were independent of the shear rate and only depended on the concentration of the polymer. We also found that the stacking sequence changed from asymmetrically twinned ABC (i.e., FCC) at low shear rates to random AB stacking at high shear rates.
A modular power electronics instructional laboratory (2003)

The study of power electronics draws upon a broad range of knowledge and often required a fair amount of experience. This suggests that laboratory instruction should be an integral component of a power electronics curriculum. However, before a single watt is delivered, the student must understand not only the operation of the converter topology but also more advanced concepts such as control theory, gate drive isolation, and layout issues. Our approach is to use a "blue box" module were these details are pre-built for convenience, but not hidden inside a "black box." Improvements to our "blue box" modules are described in this paper and include a dual-MOSFET control box with independently isolated FET devices and a high quality PWM inverter built discretely.
Efficient 193 am generation by eighth harmonics of Er/sup 3+/-doped fiber amplifier (2000)

We demonstrate the first narrow-band 193 nm source using eighth harmonic generation from the output of an Er-doped fiber amplifier at 1547nm. Conversion efficiency from the fundamental, 1547nm to 193nm is 7.9%. To our knowledge, this represents the highest conversion efficiency ever achieved for 103nm generation by frequency conversion.
P1‐053: COGNITIVE AND ELECTROPHYSIOLOGICAL MEASURES OF A PHASE 1 SINGLE ASCENDING DOSE STUDY OF THE MUSCARINIC POSITIVE ALLOSTERIC MODULATOR VU319 (2019)

The development of neurotransmitter based cognitive enhancers for Alzheimer's disease have focused recently on allosteric modulation, as a way of reducing potential drug-limiting toxicities that have been the hallmark of earlier orthosteric compounds. VU319 is an experimental positive allosteric modulator of the M1 muscarinic acetylcholine receptor that has recently begun clinical testing in healthy volunteers. Cognitive tasks and event-related potentials (ERPs) were used during the randomized, double-blind, placebo-controlled Single Ascending Dose study of VU319 to identify early markers of efficacy and target engagement. VU319 is an investigational new drug that has not been approved by the FDA for any use. VU319 was given orally to 40 healthy volunteers aged 18–55 years in five dose escalating cohorts of eight participants, in which six received VU319 and two received placebo. Cognitive and electrophysiological tasks were examined pre-dosing and at 5 hours post-dose. The tasks were selected for their sensitivity to cholinergic tone. Cognitive tasks tested spatial and sustained attention, episodic and working memory, perceptual vigilance and psychomotor speed. Tasks recorded by EEG tested auditory and visual attention using oddball tasks, and an incidental memory task in which participants passively observed novel and repeated complex images. The analysis suggests a trend for improvements in cognitive and ERP performance on the higher doses of VU319 compared to placebo. Participants on the highest dose of VU319 appeared to respond faster to targets on the continuous performance test compared to participants on placebo (effect size d = 1.2). Additionally, participants who received the higher two doses of VU319 exhibited larger incidental memory response (greater amplitudes to repeated vs. novel images) compared to placebo (d > 0.8). We conclude that these preliminary Results suggest potential enhancement of the cholinergic system in healthy adults following a single dose of VU319. These early Results indicate potential measures that are sensitive to target engagement by VU319 and support the examination of multiple doses of VU319 in healthy volunteers or patients.
Parallelized SSTF-overlapping foci in space and time (Conference Presentation) (2018)

Simultaneous spatio-temporal focusing describes the technique of spectrally dispersing an ultrashort pulse to increase it’s duration, before recombining all the spectral components to reform the short pulse at the focus of a lens. This has several advantages for optical applications using ultrashort pulses, enabling a focus with large lateral extent but displaying much greater axial confinement than with conventional focussing. Meanwhile non-linear propagation inside samples is also minimised. We extend the technique to generate multiple SSTF focal spots via holography. In contrast to previous implementations, a phase hologram is placed in the ultrafast beam while it is spatially chirped. Thus, we show that it is possible to create multiple focal spots formed by SSTF arranged in three dimensions. Demonstrations are given for ultrashort pulse laser machining on the surface and inside glass. Furthermore, due to the strong pulse front tilt exhibited by an SSTF spot, we show how multiple spots can be stitched together in space and time to generate extended intensity distributions. Spatially overlapped regions can be overlapped in time using the property of pulse front tilt such that holographic arrays of SSTF spots can be created with apparently no spatial separation.
Pharmacokinetic serum concentrations of VRC01 correlate with prevention of HIV-1 acquisition (2023)

Was provided by the National Institutes of Health, National Institute of Allergy and Infectious Diseases (NIAID) (UM1 AI068614, to the HIV Vaccine Trials Network [HVTN]; UM1 AI068635, to the HVTN Statistical Data and Management Center [SDMC], Fred Hutchinson Cancer Center [FHCC]; 2R37 054165 to the FHCC; UM1 AI068618, to HVTN Laboratory Center, FHCC; UM1 AI068619, to the HPTN Leadership and Operations Center; UM1 AI068613, to the HIV Prevention Trials Network [HPTN] Laboratory Center; UM1 AI068617, to the HPTN SDMC; and P30 AI027757, to the Center for AIDS Research, Duke University (AI P30 AI064518) and University of Washington (P30 AI027757) Centers for AIDS Research; R37AI054165 from NIAID to the FHCC; and OPP1032144 CA-VIMC Bill & Melinda Gates Foundation.
On the generalised stochastic Petri net modeling of message-oriented middleware systems (2005)

This paper presents how to model and carry out the performance analysis of message-oriented middleware (MOM) using generalised stochastic Petri Net (GSPN) models. The results obtained from the Petri net analysis are compared against ones measured in a commercial MOM. Additionally, some results are presented in order to demonstrate the flexibility and the benefits of the proposed model. This research also focuses on how to improve the MOM performance by suggesting appropriated techniques and adjustments to the MOM basic architecture. Finally, we point out some decisions usually taken by systems administrators that may have a major impact on the performance of MOM systems.
Rapid estimation of cortical neuron activation thresholds by transcranial magnetic stimulation using convolutional neural networks (2023)

3D CNNs can estimate rapidly and accurately the TMS activation thresholds of biophysically realistic neuron models using sparse samples of the local E-field, enabling simulating responses of large neuron populations or parameter space exploration on a personal computer.
Therapeutic Mesenchymal Stromal Cells for Immunotherapy and for Gene and Drug Delivery (2020)

Mesenchymal stromal cells (MSCs) possess several fairly unique properties that, when combined, make them ideally suited for cellular-based immunotherapy and as vehicles for gene and drug delivery for a wide range of diseases and disorders. Key among these are: (1) their relative ease of isolation from a variety of tissues; (2) the ability to be expanded in culture without a loss of functionality, a property that varies to some degree with tissue source; (3) they are relatively immune-inert, perhaps obviating the need for precise donor/recipient matching; (4) they possess potent immunomodulatory functions that can be tailored by so-called licensing <i>in vitro</i> and <i>in vivo</i>; (5) the efficiency with which they can be modified with viral-based vectors; and (6) their almost uncanny ability to selectively home to damaged tissues, tumors, and metastases following systemic administration. In this review, we summarize the latest research in the immunological properties of MSCs, their use as immunomodulatory/anti-inflammatory agents, methods for licensing MSCs to customize their immunological profile, and their use as vehicles for transferring both therapeutic genes in genetic disease and drugs and genes designed to destroy tumor cells.
The Simplest Ubitron in Crossed Fields (2006)

We present the simplest type of an M-type ubitron in the form of a magnetically insulated coaxial diode with a cathode consisting of N individual longitudinal strips (explosive electron emitters) periodically arranged on an imaginary cylindrical surface mounted coaxially within a pipe. In spite of the simple design the operation of this device is not easily predicted, although we can definitely state that in the ubitron, as in the RPM, azimuthal recurrence provides inner feedback that leads to an absolute instability in the electron sheath-electromagnetic field interacting system; in other words, the ubitron can operate as an oscillator. The suggested oscillator can be interesting owing to its simple design and simple control of characteristics of radiation (with single frequency radiation as well as multi-mode one) by variation of the value and direction of the guide magnetic field
Chronic wireless neural population recordings with common marmosets (2021)

SUMMARY Marmosets are an increasingly important model system for neuroscience in part due to genetic tractability and enhanced cortical accessibility, due to a lissencephalic neocortex. However, many of the techniques generally employed to record neural activity in primates inhibit the expression of natural behaviors in marmosets precluding neurophysiological insights. To address this challenge, we developed methods for recording neural population activity in unrestrained marmosets across multiple ethological behaviors, multiple brain states, and over multiple years. Notably, our flexible methodological design allows for replacing electrode arrays and removal of implants providing alternative experimental endpoints. We validate the method by recording sensorimotor cortical population activity in freely moving marmosets across their natural behavioral repertoire and during sleep. HIGHLIGHTS – Simultaneous and chronic wireless neural population recordings in multiple freely moving marmosets – Neural recording approach enables studies of natural repertoire of behaviors and sleep – Methyl-methacrylate free surgical approach designed to promote biocompatibility and longitudinal success of the implant – Modular headstage configuration requires minimal daily animal handling for daily neural recordings – Alternative experimental endpoints: implant removal, healing, and electrode array replacement
Field Reversed Configuration (FRC) Fusion Rocket (1994)

A design study of a D‐3He fueled fusion rocket employing field‐reversed configuration (FRC) is carried out for the purpose of understanding the issues that need further study and illustrating the potential advantages of this approach. The design is evolved from a terrestrial fusion power reactor ARTEMIS. From the design study, it is found that the FRC rocket could achieve a high specific power of about 1 kW/kg.
Lewis Acid Catalyzed C-H Bond Functionalization/HydrideTransfer (2009)

The authors report a transition-metal free hydride transfer/cyclization reaction activated by Lewis acidic boron. A preliminary scope is reported with good yields and diastereoselectivities. Notably, a substrate derived from (-)-menthol provided a single diastereomer.