gebhart/patrepeval huggingface dataset:
Additional Figure 4, Etherington and Monaghan (2014)

Genome-wide SNP density plots for bak1-5 mob1. All SNPs with allele frequencies &gt;75% are plotted in grey, while candidate causative SNPs (defined as those causing non-synonymous changes in gene-coding regions) are plotted in red.
Advances in osteogenin and related bone morphogenetic proteins in bone induction and repair. (1992)

Bone matrix is a repository of growth and differentiation factors as demonstrated by the induction of local cartilage and bone formation in rats. The bone inductive activity, termed osteogenin, can be dissociatively extracted, and it was isolated by heparin affinity, hydroxyapatite and molecular sieve chromatography. Osteogenin has been purified to homogeneity from bovine bone matrix and the sequences of several tryptic peptides have been determined. The sequences were similar to portions of the amino acid sequence deduced from the cDNA clone of bone morphogenetic protein-3 (BMP-3). The carboxyl-terminal quarter of osteogenin has sequence identity to the corresponding regions of two related proteins BMP-2A and BMP-2B. The bone inductive proteins are members of the TGF-beta superfamily, by virtue of the location of the highly conserved cysteines in their carboxyl-terminal region. Osteogenin and related BMPs initiate cartilage and bone formation in vivo. The study of the mechanism of action of these proteins will add considerable new information on the molecular signals controlling endochondral bone formation. In vitro data indicate that osteogenin stimulates the expression of the osteogenic and chondrogenic phenotypes. Our results demonstrate their profound influence on proteoglycan synthesis and degradation in bovine cartilage explant cultures. High affinity specific binding sites have been identified in both MC3T3 cells and articular chondrocytes. In vivo experiments demonstrate the efficacy of primate osteogenin in restoring large calvarial defects in adult baboons, establishing a primary role for osteogenin in therapeutic initiation and promotion of osteogenesis.
Mycobacterial lipoarabinomannan induces nitric oxide and tumor necrosis factor alpha production in a macrophage cell line: down regulation by taurine chloramine (1994)

Avirulent mycobacterium H37Ra lipoarabinomannan (LAM) elicited nitric oxide (NO) and tumor necrosis factor alpha in a dose-dependent manner in a murine macrophage cell line, RAW 264.7 cells. H37Ra LAM and recombinant gamma interferon were highly synergistic for NO production. The production of NO and the release of tumor necrosis factor alpha stimulated by H37Ra LAM plus recombinant gamma interferon in RAW 264.7 cells are inhibited by taurine chloramine.
Multi-Dimensional Modulation Formats for Adaptive Optical Transmission (2013)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text M. Eiselt, A. Dochhan, and H. Griesser, "Multi-Dimensional Modulation Formats for Adaptive Optical Transmission," in Asia Communications and Photonics Conference 2013, OSA Technical Digest (online) (Optica Publishing Group, 2013), paper AF1F.1. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Molecular modelling guided design, synthesis and QSAR analysis of new small molecule non-lipid autotaxin inhibitors (2021)

The lysophospholipase D autotaxin (ATX) generates lysophosphatidic acid (LPA) that activates six cognate G-protein coupled receptors (GPCR) in cancerous cells, promoting their motility and invasion.Four novel compounds were generated aided by molecular docking guided design and synthesis techniques to obtain new dual inhibitors of ATX and the lysophosphatidic acid receptor subtype 1 (LPAR1).Biological evaluation of these compounds revealed two compounds, 10 and 11, as new ATX enzyme inhibitors with potencies in the range of 218-220 nM and water solubility (> 100 μg/mL), but with no LPAR1 inhibitory activity.A QSAR model was generated that included four newly designed compounds and twenty-one additional compounds that we have reported previously.The QSAR model provided excellent predictability of the pharmacological activity and potency among structurally related drug candidates.This model will be highly useful in guiding the synthesis of new ATX inhibitors in the future.
Supplementary Figure Legends from Inhibition of Age-Related Therapy Resistance in Melanoma by Rosiglitazone-Mediated Induction of Klotho (2023)

&lt;p&gt;Legends to supplementary figures&lt;/p&gt;
Micro-optical coherence tomography-confocal fluorescence microscopy (µOCT-FCM) for probing cystic fibrosis pathogenesis (Conference Presentation) (2023)

Cystic fibrosis is the most common fatal genetic disorder in the US. In airways with CF, bicarbonate concentration affects airway liquid pH, which then modulates mucogenesis. Causative relationships between these chemical parameters and the functional microanatomy during pathogenesis and disease progression are unclear due to the lack of quantitative tools suitable for in situ studies. We utilized a new µOCT-FCM system to measure the airway functional microanatomy parameters and subsequent pH in the mucus in situ in a non-contact manner. We demonstrated the quantification of pH of the ASL using SNARF-1 in a spatially resolved manner. The µOCT-FCM imaging allowed us to visualize pH in the mucus compartments of the airway and achieved colocalized μOCT and fluorescence imaging. In human bronchial epithelial cells, CF cell ASL pH values were lower than those in the non-CF cells as expected. Pilot results from ex-vivo swine trachea showed that tracheal mucus is heterogeneous.
ChemInform Abstract: Substrate Selectivity Studies on Glycosyl Transferases: Towards the Chemoenzymic Synthesis of High Affinity Sialyl Lewis‐x Ligands (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Temperature-independence-point properties for 0.1μm-scale pocket-implant technologies and the impact on circuit design (2003)

The temperature-independence point (TIP) of the drain current for MOS transistors in a 0.1 /spl mu/m-scale pocket-implant technology is gate-length (L/sub g/) dependent and has different magnitudes for n-MOSFET and p-MOSFET. Circuits such as ring-oscillators have a TIP, lying between the values for nand pMOSFET. The circuit TIP Is close to the n-MOSFET TIP for long L/sub g/ and gets closer to the p-MOSFET TIP for short L/sub g/. The reason is the different temperature dependence of electron and hole mobility as a function of L/sub g/. Due to the high field effect, oscillation periods of ring-oscillators with short L/sub g/ hardly improve, when the supply voltage is raised beyond the TIP. Therefore, an advantageous supply-voltage (V/sub DD/) choice for pocket-implant technologies is near the TIP of circuits, allowing a favorable combination of short switching delay and minimized temperature dependence. By designing the V/sub th,p/ closer to V/sub th,n/, not only the low power dissipation, due to the reduction of the TIP, but also the suppressed TIP fluctuation can be realized.
Speciation, Luminescence, and Alkaline Fluorescence Quenching of 4-(2-Methylbutyl)aminodipicolinic Acid (H2MEBADPA) (2011)

4-(2-Methylbutyl)aminodipicolinic acid (H(2)MEBADPA) has been synthesized and fully characterized in terms of aqueous phase protonation constants (pK(a)'s) and photophysical measurements. The pK(a)'s were determined by spectrophotometric titrations, utilizing a fully sealed titration system. Photophysical measurements consisted of room temperature fluorescence and frozen solution phosphorescence as well as quantum yield determinations at various pH, which showed that only fully deprotonated MEBADPA(2-) is appreciably emissive. The fluorescence of MEBADPA(2-) has been determined to be quenched by hydroxide and methoxide anions, most likely through base-catalyzed excited-state tautomerism or proton transfer. This quenching phenomenon has been quantitatively explored through steady-state and time-resolved fluorescence measurements. Utilizing the determined pK(a)s and quenching constants, the fluorescent intensity of MEBADPA(2-) has been successfully modeled as a function of pH.
Role of beta-lactamase in in vivo development of ceftazidime resistance in experimental Pseudomonas aeruginosa endocarditis (1987)

Two ceftazidime-resistant variants of Pseudomonas aeruginosa (PA-48, PA-60), obtained from cardiac vegetations of rabbits with endocarditis receiving ceftazidime therapy, were studied for mechanisms of resistance. Both resistant variants were stably derepressed for the type Id beta-lactamase, which was ceftazidime inducible in the parental strain (PA-96) used to initially infect the rabbits. There was no evidence of ceftazidime bioinactivation by the resistant strains, and their outer membrane permeabilities were comparable to those of the parental strain. No alterations were observed in patterns of outer membrane proteins or membrane lipopolysaccharides in the resistant variants as compared with the parental strain. Penicillin-binding protein patterns of the resistant variants revealed the absence of penicillin-binding protein 4 in both, with acquisition of a new protein of higher apparent molecular weight in PA-60. Calculation of the rate of appearance of ceftazidime in the periplasm at sub-MICs suggested that slow enzymatic hydrolysis of the beta-lactam, rather than nonhydrolytic trapping, was the major explanation for the induced resistance in vivo in strains PA-48 and PA-60.
Microstructure and texture evolution during the uniaxial tensile testing of AM30 magnesium alloy (2006)

The evolution of microstructure and texture was examd. in an AM30 alloy during uniaxial tensile testing at temps. from ambient to 350°C and at strain rates from 0.001 to 0.1/s. Samples were cut from extruded AM30 tubes along the extrusion direction. DRX was obsd. even at temps. as low as 150°C. However, it did not go to completion under any set of exptl. conditions. The microstructures near the fracture surfaces indicate that cracks are readily formed next to twins at high strain rates; such twinning-induced cracking is evident at temps. up to 200°C. Partial recrystn. also exacerbates the tendency for cavitation. No significant change in the texture occurred during straining along the extrusion direction at elevated temps. This suggests that the end-texture for extension was already set up during extrusion, which is responsible for the low ductility of the present material.
Fibre Optic Gyroscopes for Space Application (2006)

A family of space Inertial Measurement Unit with several Fibre Optic Gyroscopes have been developed, covering a large range of performance (from 0,1°/h to 0,001°/h) and space applications. We present briefly the qualification of the technology.
Pathogenesis of Influenza D Virus in Cattle (2016)

A novel influenza virus, tentatively classified as influenza D virus (IDV), was identified in swine, cattle, sheep, and goats. Among these hosts, cattle have been proposed as the natural reservoir. In this study, we show that cattle experimentally infected with IDV can shed virus and transmit it to other cattle through direct contact, but not to ferrets through fomite routes. IDV caused minor clinical signs in the infected cattle, fulfilling another of Koch's postulates for this novel agent, although other objective clinical endpoints were not different from those of control animals. Although the disease observed was mild, IDV induced neutrophil tracking and epithelial attenuation in cattle trachea, which could facilitate coinfection with other pathogens, and in doing so, predispose animals to bovine respiratory disease.
The micro to nano addressing block (MNAB) (2006)

Over the past few years, a number of techniques, including self-assembly, nanoimprint lithography and spacer-based frequency doubling, have been explored to pattern line and space structures that are considerably denser than possible with conventional photolithography, with excellent critical dimension control. In order to build useful circuits with them, an efficient way of interfacing these nanoscale lines with the photolithographically defined peripheral circuits is needed. While many solutions to this problem have been proposed, for the first time, we report a solution (MNAB) that is (a) fully silicon-process compatible, (b) non-stochastic (i.e. is completely deterministic,) and (c) does not require any critical alignment. The MNAB uses discrete analog potentials to deplete and switch off certain nanoscale lines enabling selection of the remaining nanoscale line. Simulation results show that individual nanoscale silicon lines can be addressed with selectivities (ratio of current in conducting line to that in depleted lines) exceeding 100times at features as small as 10 nm using this concept. Experimental results on various silicon prototypes show that selectivities exceeding 100times can be easily obtained even on sub-20 nm features
Regional Differences of Adenylate Cyclase Stimulation by Calcitonin and Calcitonin Gene-Related Peptide in the Human Kidney* (1989)

Calcitonin (CT) gene-related peptide (CGRP)-like immunoreactivity was detected in both the cortex and medullo-papillary portion of human kidneys. The two forms of human CGRP as well as rat CGRP were capable of stimulating renal cortical adenylate cyclase activity in a concentration-related manner, with a half-maximally effective concentration (EC50) similar to that of human CT and approximately 100-1000 times higher than that of salmon CT. However, in the medullo-papillary portion, in which both salmon CT and human CT were inactive, the two forms of human and rat CGRP increased adenylate cyclase activity by 100%, with EC50 values ranging from 36 nmol/L to 1 mumol/L. In cortical membrane preparations the effect of CGRP was additive to that of salmon CT. We concluded that regional differences exist in the effect of CT and CGRP in human renal tissue and that in the medullo-papillary portion and possibly in the cortex, CGRP stimulates adenylate cyclase activity through a CT-independent mechanism.
Topics in LIFE Target Survival: 11-SI-004 Final Report (2014)

The LIFE target design incorporates many considerations to generate the desired fusion gain including the physics design, the cost of manufacturing of the target, the injectability of the target, the aerodynamic flight characteristics of the target, the ability to track and engage the target and to maintain the structural and thermal integrity of the target. This document describes the effort that was made in support of issues of survivability of the target during injection which included issues massmanufactural materials and processes which could be used in the target.
A QUALITATIVE ANALYSIS OF FLUID SIMULATION USING A SPH VARIATION (2015)

Fluid simulation using meshless methods has increasingly become a robust way to solve mechanics problems that require dealing with large deformations, in that way, it is briefly shown what the main challenges and advances in the area are. The smoothed particle hydrodynamics (SPH) is then introduced. One of its variations is the Weakly Compressible SPH (WCSPH), which was used as a baseline to implement the method used in this work, called XSPH. Finally, four usual test cases of fluid simulation are analyzed: the lid-driven cavity flow, the dam break, the Poiseuille flow and the elliptic drop. The analysis concluded that the method used in this work performs at least as well as the most reliable and accurate models, and in some aspects performs better.
ChemInform Abstract: PORPHYRIN‐ANNULENE REDOX‐RELATED LIGAND PAIR, ELECTROCHEMICAL SYNTHESIS AND CHARACTERIZATION OF THE REDUCTION PRODUCTS OF THE COBALT, COPPER, AND NICKEL COMPLEXES OF A TETRAAZA(16)ANNULENE (1974)

Abstract Die elektrochemische Reduktion der Metallkomplexe (I) mit einer gesättigten Kalomelektrode als Bezugselektrode in Methanol führt zur Bildung von Komplexen mit formal 1‐wertigem bzw. O‐wertigem Metall z.B. Ni, die bei kontrolliertem Potential auch dargestellt werden.
Hervé and Krebs Type Magnetic Polyoxometalate Dimers (2022)

Lacunary polyoxometalates (POMs) are negatively charged metal−oxo clusters, formally obtained from plenary topologies via fragment removal. Owing to the fragment removal, the lacunary POMs archetypes are rich in nucleophilic terminal oxo ligands, making them suitable for post-synthetic coordination with various heterometals. Trilacunary heteropolytungstates (het-ero-POTs) based on bowl-shaped {W9O30} framework incorporating a central lone-pair containing {XO3} hetergroup (X = AsIII, SbIII, and BiIII) function as all-inorganic scaffolds that in the presence of d-block metal cations typically construct sandwich-like dimers of Hervé and/or Krebs. Herein we review the preparative approaches, compositional and magnetic versatility of the constructing Hervé and Krebs type dimers and discuss prospective use as POMtronics.
Preclinical Evaluation of 203/212Pb-Labeled Low-Molecular-Weight Compounds for Targeted Radiopharmaceutical Therapy of Prostate Cancer (2019)

Targeted radiopharmaceutical therapy (TRT) using α-particle radiation is a promising approach for treating both large and micrometastatic lesions. We developed prostate-specific membrane antigen (PSMA)-targeted low-molecular-weight agents for <sup>212</sup>Pb-based TRT of patients with prostate cancer (PC) by evaluating the matching γ-emitting surrogate, <sup>203</sup>Pb. <b>Methods:</b> Five rationally designed low-molecular-weight ligands (L1-L5) were synthesized using the lysine-urea-glutamate scaffold, and PSMA inhibition constants were determined. Tissue biodistribution and SPECT/CT imaging of <sup>203</sup>Pb-L1-<sup>203</sup>Pb-L5 were performed on mice bearing PSMA(+) PC3 PIP and PSMA(-) PC3 flu flank xenografts. The absorbed radiation dose of the corresponding <sup>212</sup>Pb-labeled analogs was determined using the biodistribution data. Antitumor efficacy of <sup>212</sup>Pb-L2 was evaluated in PSMA(+) PC3 PIP and PSMA(-) PC3 flu tumor models and in the PSMA(+) luciferase-expressing micrometastatic model. <sup>212</sup>Pb-L2 was also evaluated for dose-escalated, long-term toxicity. <b>Results:</b> All new ligands were obtained in high yield and purity. PSMA inhibitory activities ranged from 0.10 to 17 nM. <sup>203</sup>Pb-L1-<sup>203</sup>Pb-L5 were synthesized in high radiochemical yield and specific activity. Whole-body clearance of <sup>203</sup>Pb-L1-<sup>203</sup>Pb-L5 was fast. The absorbed dose coefficients (mGy/kBq) of the tumor and kidneys were highest for <sup>203</sup>Pb-L5 (31.0, 15.2) and lowest for <sup>203</sup>Pb-L2 (8.0, 4.2). The tumor-to-kidney absorbed dose ratio was higher for <sup>203</sup>Pb-L3 (3.2) and <sup>203</sup>Pb-L4 (3.6) than for the other agents, but with lower tumor-to-blood ratios. PSMA(+) tumor lesions were visualized through SPECT/CT as early as 0.5 h after injection. A proof-of-concept therapy study with a single administration of <sup>212</sup>Pb-L2 demonstrated dose-dependent inhibition of tumor growth in the PSMA(+) flank tumor model. <sup>212</sup>Pb-L2 also demonstrated an increased survival benefit in the micrometastatic model compared with <sup>177</sup>Lu-PSMA-617. Long-term toxicity studies in healthy, immunocompetent CD-1 mice revealed kidney as the dose-limiting organ. <b>Conclusion:</b><sup>203</sup>Pb-L1-<sup>203</sup>Pb-L5 demonstrated favorable pharmacokinetics for <sup>212</sup>Pb-based TRT. The antitumor efficacy of <sup>212</sup>Pb-L2 supports the corresponding <sup>203</sup>Pb/<sup>212</sup>Pb theranostic pair for PSMA-based α-particle TRT in advanced PC.
Discovery of inference rules for question-answering (2001)

One of the main challenges in question-answering is the potential mismatch between the expressions in questions and the expressions in texts. While humans appear to use inference rules such as ‘X writes Y’ implies ‘X is the author of Y’ in answering questions, such rules are generally unavailable to question-answering systems due to the inherent difficulty in constructing them. In this paper, we present an unsupervised algorithm for discovering inference rules from text. Our algorithm is based on an extended version of Harris’ Distributional Hypothesis, which states that words that occurred in the same contexts tend to be similar. Instead of using this hypothesis on words, we apply it to paths in the dependency trees of a parsed corpus. Essentially, if two paths tend to link the same set of words, we hypothesize that their meanings are similar. We use examples to show that our system discovers many inference rules easily missed by humans.
Adaptive optics for microscopy, optical data storage, and micromachining (2006)

Many high-resolution optical methods are affected by the presence of optical aberrations. These include microscopy, three-dimensional optical data storage and optical micromachining. We investigate the use of adaptive aberration correction applied to these techniques. In particular, it is shown how a deformable membrane mirror can be used to correct the aberrations when focusing deep into a multilayer optical data storage medium for both recording and read-out of data. Aberration correction for optical micromaching deep inside a substrate is also demonstrated.
Work function engineering via LaAlO3/SrTiO3polar interfaces (2011)

By in situ Kelvin probe measurement combined with pulsed laser deposition, we have observed a change in the work function of (Nb:)SrTiO${}_{3}$(100) as LaAlO${}_{3}$(100) polar film is deposited, which strongly depends on the termination of the SrTiO${}_{3}$(100) surface and on the presence of the insulating SrTiO${}_{3}$(100) buffer layer. A sharp work function drop with LaAlO${}_{3}$(100) film deposition on a TiO${}_{2}$-terminated SrTiO${}_{3}$(100) surface would indicate the contribution of high-density electron gas at the interface to the unusual work function lowering. The present finding demonstrates that insulator-on-insulator structures using polar films could be a powerful platform to design artificial electronic states.
CO2 Storage in deep saline aquifers: impacts of fractures on hydrodynamic trapping (2021)

Natural or induced fractures are typically present in subsurface geological formations. Therefore, they need to be carefully studied for reliable estimation of the long-term carbon dioxide storage. Instinctively, flow-conductive fractures may undermine storage security as they increase the risk of CO2 leakage if they intersect the CO2 plume. In addition, fractures may act as flow barriers, causing significant pressure gradients over relatively small regions near fractures. Nevertheless, despite their high sensitivities, the impact of fractures on the full-cycle storage process has not been fully quantified and understood. In this study, a numerical model is developed and applied to analyze the role of discrete fractures on the flow and transport mechanism of CO2 plumes in simple and complex fracture geometries. A unified framework is developed to model the essential hydrogeological trapping mechanisms. Importantly, the projection-based embedded discrete fracture model is incorporated into the framework to describe fractures with varying conductivities. Impacts of fracture location, inclination angle, and fracture-matrix permeability ratio are systemically studied for a single fracture system. Moreover, the interplay between viscous and gravity forces in such fractured systems is analyzed. Results indicate that the fracture exhibits differing effects regarding different trapping mechanisms. Generally speaking, highly-conductive fractures facilitate dissolution trapping while weakening residual trapping, and flow barriers can assist dissolution trapping for systems with a relatively low gravity number. The findings from the test cases for single fracture geometries are found applicable to a larger-scale domain with complex fracture networks. This indicates the scalability of the study for field-relevant applications.