gebhart/patrepeval huggingface dataset:
Crosstalk analysis of ring resonator switches for all-optical routing (2016)

Optical switches based on ring resonator cavities were fabricated by a silicon photonics foundry process and analyzed for optical crosstalk at various data rates and channel spacings. These devices were compared to commercial bandpass filters and at 20Gb/s, 0.5dB power penalty is observed due to spectral filtering for bit error ratio threshold of 1 × 10<sup>-9</sup>. Concurrent modulation at 20Gb/s with a channel spacing as narrow as 40GHz shows error-free transmission with 1dB power penalty as compared to wider channel spacing for the ring-based switch.
Data from Genetic Alterations in the Tyrosine Kinase Transcriptome of Human Cancer Cell Lines (2023)

&lt;div&gt;Abstract&lt;p&gt;Protein tyrosine kinases (PTKs) play a critical role in the manifestation of cancer cell properties, and respective signaling mechanisms have been studied extensively on immortalized tumor cells. To characterize and analyze commonly used cancer cell lines with regard to variations in the primary structure of all expressed PTKs, we conducted a cDNA-based sequence analysis of the entire tyrosine kinase transcriptome of 254 established tumor cell lines. The profiles of cell line intrinsic PTK transcript alterations and the evaluation of 155 identified polymorphisms and 234 somatic mutations are made available in a database designated “Tykiva” (&lt;i&gt;ty&lt;/i&gt;rosine &lt;i&gt;ki&lt;/i&gt;nome &lt;i&gt;va&lt;/i&gt;riant). Tissue distribution analysis and/or the localization within defined protein domains indicate functional relevance of several genetic alterations. The cysteine replacement of the highly conserved Y367 residue in fibroblast growth factor receptor 4 or the Q26X nonsense mutation in the tumor-suppressor kinase CSK are examples, and may contribute to cell line–specific signaling characteristics and tumor progression. Moreover, known variants, such as epidermal growth factor receptor G719S, that were shown to mediate anticancer drug sensitivity could be detected in other than the previously reported tumor types. Our data therefore provide extensive system information for the design and interpretation of cell line–based cancer research, and may stimulate further investigations into broader clinical applications of current cancer therapeutics. [Cancer Res 2007;67(23):11368–76]&lt;/p&gt;&lt;/div&gt;
Figure S4 from Genetic Variants of <i>VEGFA</i> and <i>FLT4</i> Are Determinants of Survival in Renal Cell Carcinoma Patients Treated with Sorafenib (2023)

&lt;p&gt;T494A is located in the 5th Ig-like domain of VEGFR-3.&lt;/p&gt;
Influence of Superlattice Structure on V-Defect Distribution, External Quantum Efficiency and Electroluminescence for Red InGaN Based µLEDs on Silicon (2022)

Achieving high quantum efficiency in long-wavelength LEDs has posed a significant challenge to the solid-state lighting and display industries. In this article, we use V-defect engineering as a technique to achieve higher efficiencies in red InGaN LEDs on (111) Si through lateral injection. We investigate the effects of superlattice structure on the V-defect distribution, the electroluminescence properties, and the external quantum efficiency. Increasing the relative thickness of In in the InGaN/GaN superlattice and the total superlattice thickness correlate with a reduction of active region defects and increased external quantum efficiencies. The highest measured on-chip EQE was 0.15% and based on Monte-Carlo ray tracing simulations for light extraction we project this would correspond to a flip-chip EQE of ~2.5%.
Standardization of Techniques for Using Planar (2D) Imaging for Aerosol Deposition Assessment of Orally Inhaled Products (2012)

Two-dimensional (2D or planar) imaging with (99m)Tc radiolabels enables quantification of whole-lung and regional lung depositions for orally inhaled drug products. This article recommends standardized methodology for 2D imaging studies. Simultaneous anterior and posterior imaging with a dual-headed gamma camera is preferred, but imaging with a single-headed gamma camera is also acceptable. Correction of raw data for the effects of gamma ray attenuation is considered essential for accurate quantification, for instance, using transmission scanning with a flood-field source of (99m)Tc or (57)Co. Evidence should be provided of the accuracy of the quantification method, for instance, by determining "mass balance." Lung deposition may be expressed as a percentage of ex-valve or ex-device dose, but should also be given as mass of drug when possible. Assessment of regional lung deposition requires delineation of the lung borders, using X-ray computed tomography, radioactive gas scans ((133)Xe or (81m)Kr), or transmission scans. When quantifying regional lung deposition, the lung should be divided into outer (O) and inner (I) zones. A penetration index should be calculated, as the O/I ratio for aerosol, normalized to that for a radioactive gas or transmission scan. A variety of methods can be used to assess lung deposition and distribution. Methodology and results should be documented in detail, so that data from different centers may be compared. The use of appropriate methodology will provide greater confidence in the results of 2D imaging studies, and should allay concerns that such studies are qualitative or semiquantitative in nature.
Improved language modeling for conversational applications using sentence quality (2010)

In this paper, we propose a new approach to build language models for conversationals system using a a corpus of text as a opposed to a live or a Wizard-of-Oz collection. Each sentence in the corpus is assigned a “quality” that reflects the developer's intuition for how likely that sentence is to be spoken by a real user to the live system. Language Models (LM) are built for each sentence quality and these are subsequently interpolated to produce the final model. We also have built a classifier that assigns sentence qualities to the data, and whose subsequent language models achive similar improvements in word and turn error rate.
Catalytic Asymmetric Olefin Metathesis (2001)

This paper provides a survey of the first examples of efficient catalytic enantioselective olefin metathesis reactions. Mo-catalyzed asymmetric ring-closing (ARCM) and ring-opening (AROM) reactions allow access to myriad optically enriched compounds that are otherwise difficult to access.
InGaAsN/AlGaAs P-n-p heterojunction bipolar transistor (2000)

We have demonstrated a functional P-n-p heterojunction bipolar transistor (HBT) using InGaAsN. The metalorganic-vapor-phase-epitaxy-grown Al0.3Ga0.7As/In0.03Ga0.97As0.99N0.01 HBT takes advantage of the narrower band gap energy (Eg=1.2 eV) of In0.03Ga0.97As0.99N0.01, which is lattice matched to GaAs. Compared with the Al0.3Ga0.7As/GaAs material system, the Al0.3Ga0.7As/In0.03Ga0.97As0.99N0.01 material system has a larger conduction-band offset, while the valence-band offset remains comparable. This characteristic band alignment is very suitable for P-n-p HBT applications. The device’s peak current gain is 23, and it has a turn-on voltage of 0.77 V, which is 0.25 V lower than in a comparable P-n-p Al0.3Ga0.7As/GaAs HBT.
Vibrational spectra of Cs3Tl2Cl9, Au2Cl6, Nb2Cl10, Nb2Br10, Ta2Cl10, Ta2Br10 (1968)

Raman and i.r. spectral data for the compounds Cs3Tl2Cl9, Au2Cl6, Nb2Cl10, Nb2Br10, Ta2Cl10, and Ta2Br10, together with appropriate normal-co-ordinate calculations, are reported. In the case of Cs3Tl2Cl9 the assignments of Raman-active bands are supported by oriented single-crystal measurements. Vibrational data are also given for the MX6– species (where M = Nb or Ta; X = Cl or Br).
A MEMS rate integrating gyroscope based on catch-and-release mechanism for low-noise continuous angle measurement (2018)

We present two new techniques effective in realizing high precision MEMS Rate Integrating Gyroscope (RIG). First one is the application of the Catch-and-Release (CR) scheme, reported previously, to the RIG. We show that continuous angle measurement can be attained by catching and releasing a pair of CR-RIGs in a complementary manner. Direct angle measurement is also demonstrated by adopting a doughnut-shaped CR-RIG. Second one is a resistive tunable damper that can compensate the damping asymmetry, a major cause of the angle drift. In this tunable damper, the mechanical damping factor can be tuned by resistance and voltage. We show that the theoretical model fits well with the experimental results.
Augmented IL-7 Signaling during Viral Infection Drives Greater Expansion of Effector T Cells but Does Not Enhance Memory (2006)

IL-7 signals are crucial for the survival of naive and memory T cells, and the IL-7R is expressed on the surface of these cells. Following viral infection, the IL-7R is expressed on only a subset of effector CD8 T cells, and has been demonstrated to be important for the survival of these memory precursors. IL-7 message levels remain relatively constant during the T cell response to lymphocytic choriomeningitis virus, but a short-lived burst of GM-CSF is observed soon after infection. Retroviral expression of a chimeric GM-CSF/IL-7R, in which binding of GM-CSF by T cells leads to IL-7 signaling, allows for the delivery of an IL-7 signal in all effector T cells expressing the receptor. In mice infected with lymphocytic choriomeningitis virus, CD8 and CD4 T cells transduced with this chimeric receptor underwent an enhanced proliferative response compared with untransduced populations in the same host. Similarly, TCR transgenic CD8 cells expressing the chimeric receptor produced higher effector numbers during the peak of the T cell response to infection. Surprisingly, the enhanced proliferation did not lead to higher memory numbers, as the subsequent contraction phase was more pronounced in the transduced cell populations. These findings demonstrate that artificial IL-7 signaling during an infection leads to significantly increased Ag-specific effector T cell numbers, but does not result in increased numbers of memory progeny. The extent of contraction may be dictated by intrinsic factors related to the number of prior cell divisions.
Potential new drug therapies in advanced renal cell carcinoma - an investigation of different combinatory drug regimens on the proliferation of cultured human renal cell carcinoma cells. (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

5550 

Renal cell carcinoma accounts for approximately 2–3% of all malignancies. Contrary to localized disease, which often can be cured by surgery, there is no effective treatment for metastatic renal cell cancer. Due to the lack of clinically relevant antiproliferative drugs, we investigated several combinatory regimens of recently developed drugs. Using UMRC3 cells as a model for metastatic renal cell cancer, we studied the effect of monotherapy compared to that of a combination of Imatinib, 2-Methoxyestradiol (2ME2) and/or 3-(5′-hydroxymethyl-2′-furyl)-1-benzylindazole (YC-1) on cell proliferation. Due to the different mechanisms of action of these drugs - Imatinib, a receptor tyrosine kinase inhibitor, is known to inhibit the bcr-abl fusion protein, stem-cell factor receptor c-Kit, and platelet derived growth factor receptor (PDGFR) signaling; 2ME2, an estrogen metabolite, inhibits hypoxia-inducible factor-1, a key angiogenic transcription factor and stabilizes microtubules while YC-1 known as an inhibitor of platelet aggregation blocks HIF-1 - we evaluated whether an additive or even synergistic antiproliferative effect could be achieved. We identified doses for which cell proliferation is inhibited by 25%. Using these doses, we found additive inhibitory effects using a combination of Imatinib and YC-1 as well as 2ME2 and YC-1. Synergistic antiproliferative effects could be demonstrated by combining Imatinibwith 2ME2 and all three drugs. Our data indicate a greater efficacy of renal cell cancer inhibition by using combinatory drug therapies compared to a single drug application. Due to the low dosage of each drug, a lower toxicity profile could be assumed. We are currently examining the mechanism of these additive and synergistic activities in vitro and in vivo.
Periodic Mesoporous Ionosilica Nanoparticles for BODIPY Delivery and Photochemical Internalization of siRNA (2023)

Periodic Mesoporous Ionosilica Nanoparticles (PMINPs) made via co-condensation reactions starting from an ionosilica precursor and a porphyrin derivative were used for simultaneous BODIPY/siRNA delivery in cancer cells. We observed high BODIPY loading capacities and efficiencies of the PMINPs that are triggered by anion exchange. siRNA adsorption took place on the surface of the nanoparticles, whereas BODIPY was encapsulated within the core of the nanoparticles. BODIPY release was found to be pH-dependent. Our results indicate 94 % BODIPY release after 16 h at pH 4, whereas only 2 % were released at pH 7.4. Furthermore, complexation with siRNA against luciferase gene was observed at the surface of PMINPs and gene silencing through its delivery via photochemical internalization (PCI) mechanism was efficient in MDA-MB-231 breast cancer cells expressing stable luciferase.
Amyloid-β targeting immunisation in aged non-human primate ( Microcebus murinus ) (2022)

Abstract Non-human primates have an important translational value given their close phylogenetic relationship to humans. Studies in these animals remain essential for evaluating efficacy and safety of new therapeutic approaches, particularly in aging primates that display Alzheimer’s disease (AD) -like pathology. With the objective to improve amyloid-β (Aβ) targeting immunotherapy, we investigated the safety and efficacy of an active immunisation with an Aβ derivative, K6Aβ1−30-NH2, in old non-human primates. Thirty-two aged (4-10 year-old) mouse lemurs were enrolled in the study, and received up to four subcutaneous injections of the vaccine in alum adjuvant or adjuvant alone. Even though antibody titres to Aβ were not high, pathological examination of the mouse lemur brains showed significant reduction in intracellular Aβ without inflammatory or haemorrhagic changes. Moreover, a trend for cognitive improvement was observed in the vaccinated primates, which was probably linked to Aβ clearance. This Aβ derivative vaccine appeared to be safe as a prophylactic measure based on the brain analyses and because it did not appear to have detrimental effects on the general health of these old animals.
COMPARISON OF TWO-INERTIA SYSTEMS WITH TORQUE/ACCELERATION FEEDBACKS (2002)

Most robots are driven through reduction gear units. Because of the flexibility of the drive system, the vibratory behavior is caused. The drive system of the robot joint can be modeled as a two-inertia system. In this paper, we consider the two-inertia system with the torque, motor-acceleration and load-acceleration feedbacks. First, it is explained that the inertia-ratio is a very important factor. Second, it is shown that these feedbacks can change the inertia-ratio. Next, the performances of I-P speed control systems with feedbacks are compared. Finally, the experiments are performed. As a result, the torsion vibrations are suppressed effectively.
Endosteal and periosteal blood flow quantified with dynamic contrast-enhanced fluorescence to guide open orthopaedic surgery (2020)

Due to the lack of objectively measurable or quantifiable methods to assess the bone perfusion, the success of removing devitalized bone is based almost entirely on surgeon's experience and varies widely across surgeons and centers. In this study, an indocyanine green (ICG)-based dynamic contrast-enhanced fluorescence imaging (DCE-FI) has been developed to objectively assess bone perfusion and guide surgical debridement. A porcine trauma model (n = 6 pigs × 2 legs) with up to 5 conditions of severity in loss of flow in each, was imaged by a commercial fluorescence imaging system. By applying the bone-specific hybrid plug-compartment (HyPC) kinetic model to four-minute video sequences, the perfusion-related metrics, such as peak intensity, total bone blood flow (TBBF) and endosteal bone blood flow to TBBF fraction (EFF) were calculated. The results shown that the combination of TBBF and EFF can effectively differentiate injured from normal bone with the accuracy, sensitivity and specificity of 89%, 88% and 90%, respectively. Our subsequent first in human bone blood flow imaging study confirmed DCE-FI can be successfully translated into human orthopaedic trauma patients.
Synthesis and Characterization of Mesoporous MCM-48 Containing TiO2 Nanoparticles (2005)

MCM-48 was used as the matrix for size-confined titania. Titanium was introduced into the pores of MCM-48 by wet impregnation using aqueous titanylacetylacetonate, TiO(acac)2, or tetrabutyl orthotitanate in aceton solutions. Calcination in air led to the formation of titania. XRD, TEM, and adsorption investigations confirm the deposition of nanosized particles inside the pores of the mesoporous matrix without destroying their integrity. Chemical analyses show that the titania content increases after successive loading with 14 wt % of Ti after the third impregnation. The structure and size of the particles have been characterized with UV−vis, XANES, and EXAFS spectroscopies. The particle size is 2 nm after the first loading and increases after successive loading, finally showing more than one coordination environment, including resemblance with the structure of bulk rutile-TiO2. Considering preferential occupation of the channel intersections, this leads to approximately 70% occupancy.
The Author of the "Architecture Moderne" of 1728 (1959)

Research Article| May 01 1959 The Author of the "Architecture Moderne" of 1728 Wolfgang Herrmann Wolfgang Herrmann Search for other works by this author on: This Site PubMed Google Scholar Journal of the Society of Architectural Historians (1959) 18 (2): 60–62. https://doi.org/10.2307/987978 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Wolfgang Herrmann; The Author of the "Architecture Moderne" of 1728. Journal of the Society of Architectural Historians 1 May 1959; 18 (2): 60–62. doi: https://doi.org/10.2307/987978 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentJournal of the Society of Architectural Historians Search This content is only available via PDF. Article PDF first page preview Close Modal You do not currently have access to this content.
Humidity Sensing for free—advanced thermoacoustic signal models in miniaturized photoacoustic gas sensors (2023)

This study proposes a model-based method to extract relative humidity (RH) values from non-resonant photoacoustic gas spectroscopy (PAS) sensors without using an additional physical humidity sensor. PAS sensors detect gases by injecting optical power of a specific wavelength into a closed pressure chamber, where the target gas absorbs the energy and releases thermal energy through collision processes, leading to a pressure signal that is detected by a microphone. However, PAS sensors are prone to cross sensitivity, especially from humidity, which can alter relaxation paths and interfere with the measured sound signal. The proposed method combines an analytical model that calculates the thermal conductivity of the atmosphere inside the pressure chamber with measured values of the energy content of the transient microphone signal to determine the RH values. The study demonstrates that this method can be applied to complement the system with the capability to detect humidity as well, i.e., to establish a humidity sensor without adding additional components or sensors, but only by the smart evaluation of the PAS signal. The so-established RH sensor in PAS system exhibits an absolute mean error of smaller than 5 % RH and makes the PAS systems more reliable and robust.
Continuous Cardiac Output Monitoring by Peripheral Blood Pressure Waveform Analysis (2006)

A clinical method for monitoring cardiac output (CO) should be continuous, minimally invasive, and accurate. However, none of the conventional CO measurement methods possess all of these characteristics. On the other hand, peripheral arterial blood pressure (ABP) may be measured reliably and continuously with little or no invasiveness. We have developed a novel technique for continuously monitoring changes in CO by mathematical analysis of a peripheral ABP waveform. In contrast to the previous techniques, our technique analyzes the ABP waveform over time scales greater than a cardiac cycle in which the confounding effects of complex wave reflections are attenuated. The technique specifically analyzes 6-min intervals of ABP to estimate the pure exponential pressure decay that would eventually result if pulsatile activity abruptly ceased (i.e., after the high frequency wave reflections vanish). The technique then determines the time constant of this exponential decay, which equals the product of the total peripheral resistance and the nearly constant arterial compliance, and computes proportional CO via Ohm's law. To validate the technique, we performed six acute swine experiments in which peripheral ABP waveforms and aortic flow probe CO were simultaneously measured over a wide physiologic range. We report an overall CO error of 14.6%.