gebhart/patrepeval huggingface dataset:
Observation of Biexcitons in Nanocrystal Solids in the Presence of Photocharging (2013)

In nanocrystal quantum dots (NQDs), generating multiexcitons offers an enabling tool for enhancing NQD-based devices. However, the photocharging effect makes understanding multiexciton kinetics in NQD solids fundamentally challenging, which is critically important for solid-state devices. To date, this lack of understanding and the spectral-temporal aspects of the multiexciton recombination still remain unresolved in solid NQD ensembles, which is mainly due to the confusion with recombination of carriers in charged NQDs. In this work, we reveal the spectral-temporal behavior of biexcitons (BXs) in the presence of photocharging using near-unity quantum yield CdSe/CdS NQDs exhibiting substantial suppression of Auger recombination. Here, recombinations of biexcitons and single excitons (Xs) are successfully resolved in the presence of trions in the ensemble measurements of time-correlated single-photon counting at variable excitation intensities and varying emission wavelengths. The spectral behaviors of BXs and Xs are obtained for three NQD samples with different core sizes, revealing the strength tunability of the X-X interaction energy in these NQDs. The extraction of spectrally resolved X, BX, and trion kinetics, which are otherwise spectrally unresolved, is enabled by our approach introducing integrated time-resolved fluorescence. The results are further experimentally verified by cross-checking excitation intensity and exposure time dependencies as well as the temporal evolutions of the photoluminescence spectra, all of which prove to be consistent. The BX and X energies are also confirmed by theoretical calculations. These findings fill an important gap in understanding the spectral dynamics of multiexcitons in such NQD solids under the influence of photocharging effects, paving the way to engineering of multiexciton kinetics in nanocrystal optoelectronics, including NQD-based lasing, photovoltaics, and photodetection.
Transport of Pseudomonas aeruginosa in Polymer Solutions (2022)

Bacteria often live surrounded by polymer solutions, such as in animal respiratory, gastrointestinal, and reproductive tracts. In these systems, polymer solutions are often exposed to fluid flow, and their complex rheology can affect the transport of chemical compounds and microorganisms. Recent studies have focused on the effect of polymer solutions on the motility of bacteria in the absence of fluid flow. However, flow can be a game-changer on bacterial transport, as demonstrated by the depletion of motile bacteria from the low-shear regions and trapping in the high-shear regions in simple fluids, even for flows as simple as the Poiseuille one. Despite the relevance of polymer solutions in many bacterial habitats, the effect of their complex rheology on shear-induced trapping and bacterial transport in flow has remained unexplored. Using microfluidic experiments and numerical modeling, we studied how the shear rate and the rheological behavior of Newtonian and non-Newtonian polymer solutions affect the transport of motile, wild-type Pseudomonas aeruginosa in a Poiseuille flow. Our results show that, in Newtonian solutions, an increase in viscosity reduces bacterial depletion in the low-shear regions at the microchannel center, due to a reduction in the bacterial swimming velocity. Conversely, in the non-Newtonian solution, we observed a depletion comparable to the buffer case, despite its zero-shear viscosity being two orders of magnitude higher. In both cases, bacterial swimming and polymer fluid rheology control the magnitude of bacterial depletion and its shear-rate dependence. Our observations underscore the importance of the rheological behavior of the carrier fluid in controlling bacterial transport, in particular, close to surfaces giving rise to velocity gradients, with potential consequences on surface colonization and biofilm formation in many naturally relevant microbial habitats.
Optimized, practical firmware design for a novel flexible wireless multi-sensor platform for body activity and vitals monitoring (2011)

This paper proposes optimized and practical firmware development for a novel, wireless, multi-sensor, system for body activity and vitals monitoring, which improves user comfort and enables use on active mobile subjects with improved battery life.
Cloud-Powered Digital Twins: Is It Reality? (2019)

The flexibility of future production systems envisioned by Industry 4.0 requires safe but efficient Human-Robot Collaboration (HRC). An important enabler of HRC is a sophisticated collision avoidance mechanism which can detect objects and potential collision events and as a response, it calculates detour trajectories avoiding physical contacts. Digital twins provide a novel way to test the impact of different control decisions in a simulated virtual environment even in parallel. The required computational power can be provided by cloud platforms but at the cost of higher delay and jitter. Moreover, clouds bring a versatile set of novel techniques easing the life of both developers and operators. Can digital twins exploit the benefits of these concepts? Can the robots tolerate the delay characteristics coming with the cloud platforms? In this paper, we answer these questions by building on public and private cloud solutions providing different techniques for parallel computation. Our contribution is threefold. First, we introduce a measurement methodology to characterize different approaches in terms of latency. Second, a real HRC use-case is elaborated and a relevant KPI is defined. Third, we evaluate the pros/cons of different solutions and their impact on the performance.
DETERMINATION OF THE ALLOREACTIVE T CELL FREQUENCY IN VIVO: WHAT YOU GET DEPENDS UPON WHAT YOU MEASURE. (2000)

Suchin, Elliot J.1; Sayegh, Mohamed H.2; Wells, Andrew D.1; Turka, Laurence A.1 Author Information
Lipopolysaccharide Renders Transgenic Mice Expressing Human Serum Amyloid P Component Sensitive to Shiga Toxin 2 (2011)

Transgenic C57BL/6 mice expressing human serum amyloid P component (HuSAP) are resistant to Shiga toxin 2 (Stx2) at dosages that are lethal in HuSAP-negative wild-type mice. However, it is well established that Stx2 initiates extra-intestinal complications such as the haemolytic-uremic syndrome despite the presence of HuSAP in human sera. We now demonstrate that co-administering purified Escherichia coli O55 lipopolysaccharide (LPS), at a dosage of 300 ng/g body weight, to HuSAP-transgenic mice increases their susceptibility to the lethal effects of Stx2. The enhanced susceptibility to Stx2 correlated with an increased expression of genes encoding the pro-inflammatory cytokine TNFα and chemokines of the CXC and CC families in the kidneys of LPS-treated mice, 48 hours after the Stx2/LPS challenge. Co-administering the glucocorticoid dexamethasone, but not the LPS neutralizing cationic peptide LL-37, protected LPS-sensitized HuSAP-transgenic mice from lethal doses of Stx2. Dexamethasone protection was specifically associated with decreased expression of the same inflammatory mediators (CXC and CC-type chemokines and TNFα) linked to enhanced susceptibility caused by LPS. The studies reveal further details about the complex cascade of host-related events that are initiated by Stx2 as well as establish a new animal model system in which to investigate strategies for diminishing serious Stx2-mediated complications in humans infected with enterohemorrhagic E. coli strains.
The combination of ribose and adenine promotes adenosine release and attenuates the intensity and frequency of epileptiform activity in hippocampal slices: Evidence for the rapid depletion of cellular ATP during electrographic seizures (2018)

In addition to being the universal cellular energy source, ATP is the primary reservoir for the neuromodulator adenosine. Consequently, adenosine is produced during ATP-depleting conditions, such as epileptic seizures, during which adenosine acts as an anticonvulsant to terminate seizure activity and raise the threshold for subsequent seizures. These actions protect neurones from excessive ionic fluxes and hence preserve the remaining cellular content of ATP. We have investigated the consequences of manipulation of intracellular ATP levels on adenosine release and epileptiform activity in hippocampal slices by pre-incubating slices (3 h) with creatine (1 mM) and the combination of ribose (1 mM) and adenine (50 μM; RibAde). Creatine buffers and protects the concentration of cellular ATP, whereas RibAde restores the reduced cellular ATP in brain slices to near physiological levels. Using electrophysiological recordings and microelectrode biosensors for adenosine, we find that, while having no effect on basal synaptic transmission or paired-pulse facilitation, pre-incubation with creatine reduced adenosine release during Mg<sup>2+-</sup> free/4-aminopyridine-induced electrographic seizure activity, whereas RibAde increased adenosine release. This increased release of adenosine was associated with an attenuation of both the intensity and frequency of seizure activity. Given the depletion of ATP after injury to the brain, the propensity for seizures after trauma and the risk of epileptogenesis, therapeutic strategies elevating the cellular reservoir of adenosine may have value in the traumatized brain. Ribose and adenine are both in use in man and thus their combination merits consideration as a potential therapeutic for the acutely injured central nervous system.
Answering Hunt's Web Shopping Challenge: Spectral Color Management for a <italic>Virtual Swatch</italic> (2001)

In his keynote address to the Eighth Color Imaging Conference, Dr. Robert Hunt investigated the limitations of current display technology with an emphasis on how well it can be expected to represent product color on the World Wide Web. His conclusion was that for purchases where color was important, &#x201C;the best safeguard is to ask for a swatch before placing an order.&#x201D; While his analysis was compelling, we considered the topic a suitable launching point for discussion of a potential use for emerging reproduction technologies. Designed to maintain spectral integrity, some of these new approaches are now worthy of public demonstration. For discussion, a scenario is described where image files contain spectral data and are available for download from on-line vending sites. On a user's computer the downloaded files may be spectrally color managed so that when printed on a local multi-ink printer, the result would be a Virtual Swatch. If successful, such a print would reflect a good approximation of the original sample spectra. Although some of the limitations described by Hunt would remain and some new ones would be introduced, if spectral color management were fast, cheap, widely available and accurate, there would be many situations in which Web consumers would be well prepared to make color-critical purchasing decisions without the use of factory-produced swatches. Contained in these proceedings are examples of spectral reproductions using a 6-ink printer juxtaposed with original fabric samples. The examples are crude, but point toward the potential of spectral reproduction. Discussion will follow examining why these renderings are both successful and unsuccessful.
Design, development and experimental assessment of a robotic end-effector for non-standard concrete applications (2017)

Despite the recent advances in, and the adoption of robotic technologies in the construction industry, the architectural processes which demand a high degree of geometric freedom still remain largely labour intensive and manual. This is due to the inherent difficulties in robotizing the current implementation of such processes coupled with the lack of alternate robotic technologies. A specific example, which is also the focus of this paper, is that of building a steel reinforced concrete structure, with varying curvature or cross-section. This process still remains rather manual and requires extensive support of customized form-work. In this paper, first we describe an alternate novel robotic fabrication process for building steel wire meshes which act as both reinforcement and formwork. The robotization of such a process is discussed with the use of a previously developed mobile robotic system. Based on the specifications derived from the process, design of a novel custom designed robotic end-effector, enabling this process, is detailed. Automation of the full robotic system comprising the mobile robotic system and the robotic end-effector is discussed from simulation to control. Through experimental evaluation of the robotic system, we demonstrate the ability to fully automate the construction of non-standard steel reinforced steel meshes of varying curvature and cell sizes.
The role of intrarenal pH in regulation of ammoniagenesis: [31P]NMR studies of the isolated perfused rat kidney. (1981)

1. [31P]NMR spectra were obtained from a functioning isolated perfused rat kidney with the aim of determining intrarenal pH in acute acidosis. 2. Signals from intracellular inorganic phosphate could be observed in the absence of phosphate in the perfusion medium. Under these conditions renal ATP and inorganic phosphate content fell by 30% but total adenine nucleotide and phosphorylation potential ATP/ADP x Pi were unchanged compared with kidneys perfused with phosphate-containing medium. In addition, G.F.R., Na+ reabsorption and ammonia formation from glutamine remained normal. Ammonia production increased 93%, urine pH fell to 5.8 +/- 0.1 and kidney 2-oxoglutarate content fell by 80% upon acidification of the perfusion medium from pH 7.4 to pH 6.9, findings identical with those obtained in controls (Ross & Tannen, 1979). 3. [31P]NMR spectra of the isolated perfused rat kidney showed a pattern of adenine nucleotides and a small concentration of phosphocreatine, Intra-renal pH was measured from the resonance position of intracellular inorganic phosphate and in perfusions with pH 7.4 buffer was 7.19 +/- 0.10 (n = 11). 4. Acidification of the perfusion medium to pH 7.0 resulted in 0.3 pH unit fall in intrarenal pH. This fall in total intrarenal pH is insufficient to explain the fall in 2-oxoglutarate concentration observed if the glutamate-dehydrogenase-equilibrium model is invoked. 5. The line-width of the NMR signal is compatible either with heterogeneity of intra-renal pH or the existence of a pH gradient between cytosol and mitochondria, or both.
GR3027 reversal of neurosteroid-induced, GABA-A receptor-mediated inhibition of human brain function: an allopregnanolone challenge study (2018)

Oral GR3027 mitigates inhibition of brain function induced by allopregnanolone at doses which are clinically well tolerated and associated with linear pharmacokinetics.
Physiogenomic Analysis of Statin-Treated Patients: Domain-Specific Counter Effects within the ACACB Gene on Low-Density Lipoprotein Cholesterol? (2010)

Physiogenomic evidence suggests a novel link between LDLC levels and the regulation of fatty acid metabolism. The findings complement previously discovered novel SNP relationships to myalgia (pain) and myositis (serum creatine kinase activity). By genotyping for myositis, myalgia and LDLC levels, a physiogenomic model may be developed to help clinicians maximize effectiveness and minimize side effects in prescribing statins.
ABA Type Copolymers of Lactide with Poly(ethylene glycol). Kinetic, Mechanistic, and Model Studies (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTABA Type Copolymers of Lactide with Poly(ethylene glycol). Kinetic, Mechanistic, and Model StudiesYing Jun Du, Piet J. Lemstra, Atze J. Nijenhuis, Huub A. M. Van Aert, and Cees BastiaansenCite this: Macromolecules 1995, 28, 7, 2124–2132Publication Date (Print):March 1, 1995Publication History Published online1 May 2002Published inissue 1 March 1995https://pubs.acs.org/doi/10.1021/ma00111a004https://doi.org/10.1021/ma00111a004research-articleACS PublicationsRequest reuse permissionsArticle Views1002Altmetric-Citations134LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Igor Narkevich. To be continued… (2022)

The article is dedicated to the fifty-fifth birthday of a remarkable person, Professor, Rector of the Saint Petersburg Chemical and Pharmaceutical University Igor Anatolyevich Narkevich. Little-known facts about his personal life and career have been outlined. Photos from his personal archive, previously unpublished, have been posted in the article. The materials presented, in our opinion, do not claim to be a complete biography of I. A. Narkevich. It is of a biographical nature and will undoubtedly serve as additional information about this creative multifaceted personality.&#x0D; In the article, the achievements of I. A. Narkevich in studies, scientific and organizational activities successively from a secondary school student to the Rector of the university have been described.&#x0D; The authors are confident that this life example will be useful for students and future leaders of organizations in the pharmaceutical industry in achieving creative and scientific goals in their work.&#x0D; The article also contains materials on the directions and methods of modernization of pharmaceutical education implemented under the leadership of I. A. Narkevich, archive materials, scientific and journalistic articles, reports on the work of the structural units of the SPCPU, their projects and external grants, as well as records of personal conversations.
A Self-Adaptive Artificial Neural Network Technique to Estimate Static Young's Modulus Based on Well Logs (2022)

Abstract Static Young's modulus (Estatic) is an essential parameter needed to develop the earth geomechanical model, Young's modulus (E) considerably varies with the change in the lithology. Recently, artificial intelligence (AI) techniques were used to estimate Estatic for carbonate formation. In this study, artificial neural network (ANN) was used to estimate Estatic for sandstone formation. In this study, the ANN design parameters were optimized using the self-adaptive differential evolution (SaDE) optimization algorithm. The ANN model was trained to predict Estatic from conventional well log data such as bulk density, compressional time, and shear time. 409 data points from Well-A were used to train the ANN model which was then tested using 183 unseen data from the same well and validated on 11 data points from a different well (Well-B). The developed SaDE-ANN model estimated Estatic for the training data set with a very low average absolute percentage error (AAPE) of 0.46%, very high correlation coefficient (R) of 0.999 and coefficient of determination (R2) of 0.9978. And the Estatic values of testing data set were estimated with AAPE, R, and R2 of 1.46%, 0.998, and 0.9951, respectively. These results confirmed the high accuracy of the developed Estatic model.
The SOD1-mediated ALS phenotype shows a decoupling between age of symptom onset and disease duration (2022)

Superoxide dismutase (SOD1) gene variants may cause amyotrophic lateral sclerosis, some of which are associated with a distinct phenotype. Most studies assess limited variants or sample sizes. In this international, retrospective observational study, we compare phenotypic and demographic characteristics between people with SOD1-ALS and people with ALS and no recorded SOD1 variant. We investigate which variants are associated with age at symptom onset and time from onset to death or censoring using Cox proportional-hazards regression. The SOD1-ALS dataset reports age of onset for 1122 and disease duration for 883 people; the comparator population includes 10,214 and 9010 people respectively. Eight variants are associated with younger age of onset and distinct survival trajectories; a further eight associated with younger onset only and one with distinct survival only. Here we show that onset and survival are decoupled in SOD1-ALS. Future research should characterise rarer variants and molecular mechanisms causing the observed variability.
Targeted Single-Cell RNA and DNA Sequencing With Fluorescence-Activated Droplet Merger (2020)

Analyzing every cell in a diverse sample provides insight into population-level heterogeneity, but abundant cell types dominate the analysis and rarer populations are scarcely represented in the data. To focus on specific cell types, the current paradigm is to physically isolate subsets of interest prior to analysis; however, it remains difficult to isolate and then single-cell sequence such populations because of compounding losses. Here, we describe an alternative approach that selectively merges cells with reagents to achieve enzymatic reactions without having to physically isolate cells. We apply this technique to perform single-cell transcriptome and genome sequencing of specific cell subsets. Our method for analyzing heterogeneous populations obviates the need for pre- or post-enrichment and simplifies single-cell workflows, making it useful for other applications in single-cell biology, combinatorial chemical synthesis, and drug screening.
Reduced Order Modeling for Inverse Parameter Identification of Ti-5111 Friction Stir Welding (2016)

Forward and inverse modeling of the friction stir welding (FSW) process is an important endeavor, which can be used to optimize process parameters that can play a significant role on achieving specification requirements of manufactured parts. In this work a Reduced Order Modeling (ROM) approach is presented with the aim to reduce the forward step evaluation of an optimization loop that implements the solution of the relevant inverse problem. This is done in order to reduce the overall computational time required. The feasibility and efficiency of this approach is demonstrated through its implementation and the comparison between the full and the reduced order model implementations.