gebhart/patrepeval huggingface dataset:
Towards the development of a standardized performance evaluation framework for eye gaze estimation systems in consumer platforms (2016)

There is a need to standardize the performance of eye gaze estimation (EGE) methods in various platforms for human computer interaction (HCI). Because of lack of consistent schemes or protocols for summative evaluation of EGE systems, performance results in this field can neither be compared nor reproduced with any consistency. In contemporary literature, gaze tracking accuracy is measured under non-identical sets of conditions, with variable metrics and most results do not report the impact of system meta-parameters that significantly affect tracking performances. In this work, the diverse nature of these research outcomes and system parameters which affect gaze tracking in different platforms is investigated and their error contributions are estimated quantitatively. Then the concept and development of a performance evaluation framework is proposed- that can define design criteria and benchmark quality measures for the eye gaze research community.
Humidity-Responsive Liquid Crystalline Polymer Actuators with an Asymmetry in the Molecular Trigger That Bend, Fold, and Curl (2014)

We show a versatile method for the preparation of a variety of humidity-responsive actuators based on a single sheet of a hydrogen-bonded, uniaxially aligned liquid crystal polymer network. In this approach, the asymmetry in the molecular trigger in the anisotropic polymer film plays a dominant role leading to programmed deformation events. The material is locally treated with a potassium hydroxide solution to create the asymmetry in the responsiveness toward humidity, which allows to prepare actuators that bend, fold, or curl.
Discovery of a Highly Selective and Potent TRPC3 Inhibitor with High Metabolic Stability and Low Toxicity (2021)

The overactivation of transient receptor potential canonical 3 (TRPC3) is associated with neurodegenerative diseases and hypertension. Pyrazole 3 (Pyr3) is reported as the most selective TRPC3 inhibitor, but it has two inherent structural limitations: (1) the labile ester moiety leads to its rapid hydrolysis to the inactive Pyr8 <i>in vivo</i>, and (2) the alkylating trichloroacrylic amide moiety is known to be toxic. To circumvent these limitations, we designed a series of conformationally restricted Pyr3 analogues and reported that compound <b>20</b> maintains high potency and selectivity for human TRPC3 over its closely related TRP channels. It has significantly improved metabolic stability compared with Pyr3 and has a good safety profile. Preliminary evaluation of <b>20</b> demonstrated its ability to rescue Aβ-induced neuron damage with similar potency to that of Pyr3 <i>in vitro</i>. Collectively, these results suggest that <b>20</b> represents a promising scaffold to potentially ameliorate the symptoms associated with TRPC3-mediated neurological and cardiovascular disorders.
Quanitifying the Value of a Future Well Test with Reservior and Measurement (2009)

We present a consistent and functional methodology for conducting value-of-information (VoI) analysis on proposed well tests in the presence of multiple critical uncertainties associated with the reservoir and the measurement/interpretation. Such uncertainties can impact asset economics acutely when they influence recoverable hydrocarbons. A key feature of this analysis is that the value of the measurement is determined before the measurement is made. Our demonstration uses an example of a marginal offshore asset where severe compartmentalization is possible. In this example, the VoI is a critical deciding factor because it is not obvious a priori that this value will justify the cost of the test in this marginal asset. Our analysis uses a novel approach to standard decision trees by introducing new decision tree nodes in the form of “uncertainty” and “transformation uncertainty” nodes that can accommodate single or numerous continuous and discrete uncertainties. Without such novel tree components, a standard decision tree would become far too cumbersome for practical purposes and may even result in sub-optimal (uneconomic) development decisions from being made because of the discretized nature of the existing decision tree constructs. We also consider, in addition to the reservoir uncertainties, the uncertainty in the well test measurement and/or the interpretation itself. We present expected asset net present value as a function of measurement uncertainty. Since well-test uncertainty can be related to the well-test duration, we show how the optimum well-test duration can be determined by identifying the time at which the difference between VoI and test cost is maximized. The cost of running the test longer than this optimal duration will only serve to reduce the net present value of the asset.
Identification and characterization of EGF receptor in individual exosomes by fluorescence‐activated vesicle sorting (2016)

Exosomes are small, 40-130 nm secreted extracellular vesicles that recently have become the subject of intense focus as agents of intercellular communication, disease biomarkers and potential vehicles for drug delivery. It is currently unknown whether a cell produces different populations of exosomes with distinct cargo and separable functions. To address this question, high-resolution methods are needed. Using a commercial flow cytometer and directly labelled fluorescent antibodies, we show the feasibility of using fluorescence-activated vesicle sorting (FAVS) to analyse and sort individual exosomes isolated by sequential ultracentrifugation from the conditioned medium of DiFi cells, a human colorectal cancer cell line. EGFR and the exosomal marker, CD9, were detected on individual DiFi exosomes by FAVS; moreover, both markers were identified by high-resolution stochastic optical reconstruction microscopy on individual, approximately 100 nm vesicles from flow-sorted EGFR/CD9 double-positive exosomes. We present evidence that the activation state of EGFR can be assessed in DiFi-derived exosomes using a monoclonal antibody (mAb) that recognizes "conformationally active" EGFR (mAb 806). Using human antigen-specific antibodies, FAVS was able to detect human EGFR and CD9 on exosomes isolated from the plasma of athymic nude mice bearing DiFi tumour xenografts. Multicolour FAVS was used to simultaneously identify CD9, EGFR and an EGFR ligand, amphiregulin (AREG), on human plasma-derived exosomes from 3 normal individuals. These studies demonstrate the feasibility of FAVS to both analyse and sort individual exosomes based on specific cell-surface markers. We propose that FAVS may be a useful tool to monitor EGFR and AREG in circulating exosomes from individuals with colorectal cancer and possibly other solid tumours.
Potential Distribution in Functionalized Graphene Devices Probed by Kelvin Probe Force Microscopy (2011)

Kelvin probe force microscopy was used to study the impact of contacts and topography on the local potential distribution on contacted, individual functionalized graphene sheets (FGS) deposited on a SiO2/Si substrate. Negligible contact resistance is found at the graphene/Ti interface and a graphene resistance of 2.3 kΩ is extracted for a single sheet with sub‐μm size. Pronounced steps in the topography, which we attribute to a variation of the spacing between graphene and substrate, result in a significant change of the local resistivity.
An Annealed Self-Organizing Map for Source Channel Coding (1997)

We derive and analyse robust optimization schemes for noisy vector quantization on the basis of deterministic annealing. Starting from a cost function for central clustering that incorporates distortions from channel noise we develop a soft topographic vector quantization algorithm (STVQ) which is based on the maximum entropy principle and which performs a maximum-likelihood estimate in an expectationmaximization (EM) fashion. Annealing in the temperature parameter fi leads to phase transitions in the existing code vector representation during the cooling process for which we calculate critical temperatures and modes as a function of eigenvectors and eigenvalues of the covariance matrix of the data and the transition matrix of the channel noise. A whole family of vector quantization algorithms is derived from STVQ, among them a deterministic annealing scheme for Kohonen&amp;apos;s self-organizing map (SOM). This algorithm, which we call SSOM, is then applied to vector quantization of image dat...
Ultrafast semiconductor-laser-diode-seeded CrLiSAF regenerative amplifier system (1995)

An ultrafast, hybrid mode-locked semiconductor laser-diode system has been used to seed a flash-lamppumped Cr:LiSAF regenerative amplifier system, producing subpicosecond pulses with millijoule output pulse energy. This system has the potential to eliminate argon-ion-pumped-based, ultrafast laser systems. © 1997 Optical Society of America.
Towards On-Chip Coherent Photonic Logic with Amorphous Silicon Microring Resonators (2013)

We demonstrate picosecond timescale optical switching in high-Q amorphous silicon microring resonators in the 1.5-μm telecom band via cross-phase modulation. Our results indicate promising approaches for explorations of ultrafast coherent photonic logic on chip.
Synthesis and turnover of ribulose biphosphate carboxylase and of its subunits during the cell cycle of Chlamydomonas reinhardtii. (1975)

The chloroplast enzyme ribulose-1,5-bisphosphate (Ru-1,5-P2) carboxylase (EC 4.1 1.39) is made up ot two nonidentical subunits, one synthesized in the chloroplast and the other outside. Both of these subunits of the assembled enzyme are synthesized in a stepwise manner during the synchronous cell cycle of the green alga Chlamydomonas reinhardtii. The activity of this enzyme increases in the light and this increase is due to de novo protein synthesis as shown by the measurement of the amount of protein and by the pulse incorporation of radioactive arginine in the 18S enzyme peak in linear sucrose density gradients. During the dark phase of the cell cycle, there is little change in the enzymatic activity as well as in the amount of this enzyme. Pulse-labeling studies using radioactive arginine indicated that there is a slow but detectable rate of synthesis of the carboxylase and of its subunits in the dark. Ru-1,5-P2 carboxylase, prelabeled with radioactive arginine throughout the entire light period, shows a similarly slow rate of degradation in the following dark period. This slow turnover of the enzyme in the dark accounts for the steady levels of carboxylase protein and of enzymatic activity during this period. A wide variety of inhibitors of protein synthesis by 70S and 80S ribosomes abolished the incorporation of [3H]arginine into total Ru-1,5-P2 carboxylase during short-term incubation. These results suggest a tight-coordinated control of the biosynthesis of the small and large subunits of the enzyme. This stringent control is further substantiated by the finding that both subunits are synthesized in sychrony with each other, that the ratio of radioactivity of the small to the large subunit remains constant throughout the entire light-dark cycle, and that the rates of synthesis and of degradation of both subunits are similar to that of the assembled enzyme.
Targeting the Infant Gut Microbiota Through a Perinatal Educational Dietary Intervention: Protocol for a Randomized Controlled Trial (Preprint) (2019)

<sec> <title>BACKGROUND</title> The early life gut microbiota are an important regulator of the biological pathways contributing toward the pathogenesis of noncommunicable disease. It is unclear whether improvements to perinatal diet quality could alter the infant gut microbiota. </sec> <sec> <title>OBJECTIVE</title> The aim of this study is to assess the efficacy of a perinatal educational dietary intervention in influencing gut microbiota in mothers and infants 4 weeks after birth. </sec> <sec> <title>METHODS</title> The Healthy Parents, Healthy Kids randomized controlled trial aimed to recruit 90 pregnant women from Melbourne, Victoria, Australia. At week 26 of gestation, women were randomized to receive dietary advice from their doctor (n=45), or additionally receive a dietary intervention (n=45). The intervention included an educational workshop and 2 support calls aiming to align participants’ diets with the Australian Dietary Guidelines and increase intakes of prebiotic and probiotic foods. The educational design focused on active learning and self-assessment. Behavior change techniques were used to support dietary adherence, and the target behavior was eating for the gut microbiota. Exclusion criteria were age under 18 years, diagnosed mental illnesses, obesity, diabetes mellitus, diagnosed bowel conditions, exclusion diets, illicit drug use, antibiotic use, prebiotic or probiotic supplementation, and those lacking dietary autonomy. The primary outcome measure is a between-group difference in alpha diversity in infant stool collected 4 weeks after birth. Secondary outcomes include evaluating the efficacy of the intervention in influencing infant and maternal stool microbial composition and short chain fatty acid concentrations, epigenetic profile, and markers of inflammation and stress, as well as changes in maternal dietary intake and well-being. The study and intervention feasibility and acceptance will also be evaluated as secondary outcomes. </sec> <sec> <title>RESULTS</title> The study results are yet to be written. The first participant was enrolled on July 28, 2016, and the final follow-up assessment was completed on October 11, 2017. </sec> <sec> <title>CONCLUSIONS</title> Data from this study will provide new insights regarding the ability of interventions targeting the perinatal diet to alter the maternal and infant gut microbiota. If this intervention is proven, our findings will support larger studies aiming to guide the assembly of gut microbiota in early life. </sec> <sec> <title>CLINICALTRIAL</title> Australian Clinical Trials Registration Number ACTRN12616000936426; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=370939 </sec> <sec> <title>INTERNATIONAL REGISTERED REPORT</title> DERR1-10.2196/14771 </sec>
The isolation and sequence of a novel gene from a human functional T cell line. (1987)

Using a subtractive hybridization procedure we have constructed a cDNA library enriched for sequences present in functional human T cell lines, but not in human EBV-transformed B cell lines. We have isolated a cDNA clone, AH2-519, representing a novel gene, designated 519. This novel gene is expressed in functional human cytolytic and Th cell lines but not in a variety of other cell lines, including several long-term human T cell tumor lines. The expression of gene 519 is inducible in cultures of normal human PBL using antigenic or mitogenic stimulation. Neither the DNA sequence determined from a full-length cDNA clone overlapping with clone AH2-519 nor the amino acid sequence of its predicted protein product has significant homology to published sequences in the GenBank or NBRF databases. The restricted expression of gene 519 suggests that its gene product is involved in the growth and/or differentiation of normal T cells. The data also show that normal, nontransformed, functional T cells express gene products that can not be readily identified in long-term tumor lines of the same cell lineage.
Motion of intracochlear structures measured with a commercial optical coherence tomography (OCT) system (2017)

Most knowledge of the motion of cochlear structures has been limited to measurements through the round window at the extreme base of the cochlea or through a hole made in the cochlear capsule, which can modify cochlear mechanics. Optical coherence tomography (OCT) provides the ability to measure shape or motion of structures through a thin layer of tissue or bone. The motion of cochlear structures has been measured in the mouse cochlear apex without making an opening into the cochlea, using a custom OCT system. Here we describe intracochlear vibrometry using a commercial OCT system. Specimens were prepared by opening the middle ear while maintaining part of the cartilaginous ear canal. A Thorlabs 905nm Ganymede III-HR OCT system with 100-kHz camera frame rate was used to measure cochlear anatomy in a 2-D radial slice (B-scan) and dynamic displacements along a line (A-line) that intersected several cochlear structures in response to tones presented to the ear canal. Differences in the magnitude and phase of the displacements along the A-line show differences in the motion of cochlear structures. These data will provide information for validating 3D finite element models of the cochlea. [Work supported by NIDCD R01 DC07910.]
Lightweight Passive Microclimate Cooling Device (1993)

Abstract : The intermittent adsorption cooling concept has been successfully demonstrated and has produced cooling rates in the 300 W range. The design requirement of 300 W for 6 hours has not been demonstrated due to system leaks. However, we demonstrated in laboratory experiments that were scaled to a much smaller size that we have produced 325 to 432 V of cooling. Laboratory experiments also showed the system could operate for more than 8 hours, be started and stopped, when the system contained no leaks. The current prototype was constructed of brass and copper for ease of fabrication. No consideration was given to weight. We have examined alternate methods of construction of the backpack and cylinder assembly and thin (0.01 in.) stainless steel could be used. The stainless steel sheet stock could be formed into a backpack bedding the sheets into fins, which also serve to strengthen the backpack. Also, stainless steel could be used to lower the weight of the cylinders. With these changes, the system weight including water and desiccant, is 23.8 lb.
Vaccination With MAGE-3 Protein Induces A Potent Immune Response in A Healthy Donor Which Can Be Adoptively Transferred to A Multiple Myeloma Patient and Boosted by Further Vaccination (2005)

s: Abstracts for the 20th Annual Scientific Meeting of the International Society for Biological Therapy of Cancer (Primary Authors are Italicized): TURNING IMMUNIZATION INTO TUMOR REGRESSION: OBSTACLES AND STRATEGIES
5.5: Late‐News Paper : Electrically Accelerated Turn‐Off Process in the Nematic Liquid Crystals (2008)

Abstract We demonstrate for the first time that the dynamics of the nematic director during the turn‐off process can be accelerated by addressing the cell with a short voltage pulse of certain polarity. The duration of pulse is comparable to the time of dielectric relaxation of the nematic material and its polarity depends on the polarization created in the nematic bulk by the voltage applied during the turn‐on process.
Ild Preservation In The Multichannel Wiener Filter For Binaural Hearing Aid Applications (2014)

Publication in the conference proceedings of EUSIPCO, Lisbon, Portugal, 2014
Global attestation of location in mobile devices (2015)

Location information in mobile devices are very important part of any location based transactions. The information can be faked and can be misrepresented for meeting specific requirements. A number of mechanisms have been used to ensure that the location information provided by the mobile device is accurate. In this paper, we introduce the notion of gathering evidences independently where each entity reports contacts with other entities in specific locations at specific times. Some of the reports may be not true and in order to scrutinize these, we introduce the global consistency check. This is mainly based on the model similar to the block chain model in Bitcoin. With a global consistency check we can ensure if a particular entity is being dishonest about the location information. We have used the EigenTrust and PeerTrust check methodologies to calculate global and personalised trust matrix while confirming attestation. The paper also shows the importance of global attestation scheme over local attestation.
Multiple Atrial Tachycardias After Atrial Fibrillation Ablation (2011)

A combination of pulmonary vein isolation (PV), electrogram-based ablation, and linear lesions have been demonstrated to result in medium-term freedom from atrial fibrillation (AF) in the majority of patients with persistent AF in several studies. Such an extensive ablation is associated with a high incidence of postablation atrial tachycardia (AT), which is often complex and multiple. Deductive mapping strategy, 1,2 which consists of activation mapping and entrainment mapping, can identify the mechanism and/or source of the postablation AT rapidly and accurately. However, careful mapping and close observation to identify subtle changes between the ATs are necessary. Postpacing interval (PPI) mapping is a useful technique, with some limitation for focal AT. It also demonstrated the utility of PPI mapping in the precise diagnosis of the sources of focal ATs.
Top-Pinned STT-MRAM Devices With High Thermal Stability Hybrid Free Layers for High-Density Memory Applications (2018)

The hybrid free layer (HFL) design consisting of a single layer of CoFeB coupled via a spacer to [Co/Ni] multilayers was proposed previously to increase perpendicular magnetic anisotropy in the free layer of top-pinned magnetic tunnel junction stacks. It is thus expected that a high thermal stability factor (Δ) can be achieved in devices with small dimensions, which is required for data retention in high-density memory applications. Here, we report on the electrical and magnetic properties of the HFL in devices with various critical dimensions (CD), in which case the [Co/Ni] multilayers in the HFL have only one Co/Ni bilayer on Pt seed. It is shown first that the HFL can provide larger coercive field (H <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</sub> ) than dual-MgO FL counterparts. μ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> H <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</sub> around 125 mT is achieved in sub-20 nm devices with the HFL. To derive A, the field sweep method was applied. The fitting of the switching probability versus applied field was compared for a macrospin reversal and a domain wall mediated reversal (DWMR). The DWMR model is valid when the CD is larger than around 40 nm in both dual-MgO FL and HFL cases, where the switching is realized through domain wall motion as shown via micromagnetic simulations. In both regimes, the HFL provides a higher A than the dual-MgO FL.
Solid-State Amperometric Sensor Based on a Sodium Ion Conductor for Detection of Total NO[sub x] in an Atmospheric Environment (1999)

An conductor‐based amperometric sensor was designed for the detection of total in air. An original amperometric device, attached with a layer of on the counter electrode was sensitive to , but insensitive to . In order to make the device sensitive to , the sensing electrode was covered with double layers of catalysts to oxidize to , i.e., and . At the sensing electrode potential fixed at vs. the reference electrode , the current response was proportional to the concentration of or up to at . In addition, the proportionality constants (sensitivity) were almost the same to and . The current responses were hardly affected by the coexistence of and . The sensing mechanism of the present sensor was briefly discussed. ©1999 The Electrochemical Society