gebhart/patrepeval huggingface dataset:
The Ankle-Pelvic Angle (APA) and Global Lower Extremity Angle (GLA): Summary Measurements of Pelvic and Lower Extremity Compensation (2021)

APA and GLA offer a concise and simple method of communicating pelvic and lower extremity compensation.
Control region protection in LTE-A networks (2012)

The protection of downlink control signals in an LTE-Advanced (LTE-A) system is the objective of this paper. For this purpose, we develop a method, known as dynamic and autonomous control region assignment (DACRA), which is applicable to uncoordinated and (possibly) dense wireless networks. The proposed method mainly exploits the carrier aggregation and cross-carrier scheduling properties inherent to LTE-A networks. It is designed such that each base station (BS) proactively protects the control signals reserved for its own user equipments (UEs). Additionally, the interference protection does not coincide with an intolerable and unnecessary reduction in the attainable spatial reuse of radio resources. This is achieved by smartly defining two classes of resources depending on their foreseen usage by a BS and assigning them to different use cases according to the prevailing interference conditions. The effectiveness of our proposal is corroborated via systemlevel simulations which reveal that outage ratios of UEs are significantly decreased without increasing the complexity at UEs and BSs.
The Acyltransferase Homologue from the Initiation Module of the R1128 Polyketide Synthase Is an Acyl-ACP Thioesterase That Edits Acetyl Primer Units (2004)

Type II polyketide synthases (PKSs) synthesize polyfunctional aromatic polyketides through iterative condensations of malonyl extender units. The biosynthesis of most aromatic polyketides is initiated through an acetate unit derived from decarboxylation of malonyl-acyl carrier protein (ACP). Modification of this primer unit represents a powerful method of generating novel polyketides. We have demonstrated that recombination of the initiation module from the R1128 PKS with heterologous elongation modules afforded regioselectively modified polyketides containing alternative primer units. With the exception of the role of the acyltransferase homologue ZhuC, the catalytic cycle of the initiation module has been well explored. ZhuC, along with the ketosynthase III homologue ZhuH and the ACP(p) ZhuG, is essential for the in vivo biosynthesis of aromatic polyketides derived from non-acetate primer units. Here we have studied the role of ZhuC using PKS proteins reconstituted in vitro. We show that the tetracenomycin (tcm) minimal PKS can be directly primed with non-acetate acyl groups. In the presence of approximately 10 microM hexanoyl-ZhuG or approximately 100 microM hexanoyl-CoA, the tcm minimal PKS synthesized hexanoyl-primed analogues of octaketides SEK4 and SEK4b, as well as acetate-primed decaketides SEK15 and SEK15b at comparable levels. Addition of ZhuC abolished synthesis of the acetate-primed decaketides, resulting in exclusive synthesis of the hexanoyl-primed octaketides. In the absence of alternative acyl donors, ZhuC severely retarded the activity of the tcm minimal PKS. The editing capabilities of ZhuC were directly revealed by demonstrating that ZhuC has 100 times greater specificity for acetyl- and propionyl-ACP as compared to hexanoyl- and octanoyl-ACP. Thus, by purging the acetate primer units that otherwise dominate polyketide chain initiation, ZhuC (and presumably its homologues in other PKSs such as the doxorubicin and frenolicin PKSs) allows alternative primer units to be utilized by the elongation module in vivo. The abilities of other alkylacyl primer units to prime the tcm minimal PKS were also investigated in this report.
The Escherichia coli heat‐labile enterotoxin induces apoptosis of immature lymphocytes in vivo via a glucocorticoid‐dependent pathway (2005)

Escherichia coli heat-labile enterotoxin (LT) exhibits a broad range of immunomodulatory activities, including the induction of lymphocyte-programmed cell death. However, the nature of the lymphoid populations sensitive to LT-induced apoptosis and the mechanisms used by this toxin to promote such activity are still unclear. In this study, we demonstrate that LT induces in mice a rapid increase in the levels of circulating corticosterone, resulting in a dramatic induction of cell death of immature CD4+CD8+, B220+IgM- and IgM+IgD- T and B cell progenitors, respectively. Apoptosis of these cell populations is similar to that reported after experimental treatment with corticosteroids, it is inhibited by mifepristone, a glucocorticoid receptor antagonist, and does not occur in adrenalectomized animals. These results clearly indicate that endogenous glucocorticoids are the mediators of the LT-induced cell death, which involves Bcl-2-dependent apoptotic pathways. The LT-mediated programmed cell death requires systemic exposure and the enzymatic activity of LT, since a mutant devoid of any enzymatic activity have no pro-apoptotic effect at any dose tested.
On the Ergodic Mutual Information of Multiple Cluster Scattering MIMO Channels (2013)

We consider multiple cluster scattering MIMO channels, where the effective channel equals the product of n complex Gaussian matrices. The considered channel model is typical for picocell propagation environments. For this channel model, we derive a closed-form lower bound of the ergodic mutual information. The derived lower bound is asymptotically tight, and is valid for an arbitrary number of clusters n-1 and an arbitrary number of antennas. The scaling law of the ergodic mutual information is found, generalizing the known result for the conventional MIMO channel model for which n=1.
Substituent effects in the cycloaddition reactions of Reissert hydrofluoroborate salts with alkenes (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSubstituent effects in the cycloaddition reactions of Reissert hydrofluoroborate salts with alkenesWilliam E. McEwen, Maria Alcira Hernandez, Chei-Fei Ling, Elba Marmugi, Regina M. Padronaggio, Charles M. Zepp III, and Jacek J. LubinkowskiCite this: J. Org. Chem. 1981, 46, 8, 1656–1662Publication Date (Print):April 1, 1981Publication History Published online1 May 2002Published inissue 1 April 1981https://pubs.acs.org/doi/10.1021/jo00321a027https://doi.org/10.1021/jo00321a027research-articleACS PublicationsRequest reuse permissionsArticle Views85Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
FGF21 Counteracts Alcohol Intoxication by Activating Noradrenergic Neurons (2022)

SUMMARY Animals that consume fermenting fruit or nectar are exposed to ethanol, thus increasing their risk of injury or predation. This risk is heightened in humans, who have actively imbibed alcohol for thousands of years. In this report, we show that the hormone FGF21, which is strongly induced by ethanol in murine and human liver, exerts sobering or “amethystic” effects on both arousal and motor coordination without changing ethanol catabolism. Mice lacking FGF21 take longer than wild-type littermates to recover their righting reflex and balance following ethanol exposure. Conversely, pharmacologic FGF21 administration reduces the time needed for mice to recover from ethanol-induced unconsciousness and ataxia. FGF21 mediates it amethystic effects by directly activating the noradrenergic nervous system, which regulates arousal and alertness. These results indicate that this FGF21 liver-brain pathway evolved to protect against ethanolinduced intoxication and that it might be targeted pharmaceutically for treating acute alcohol poisoning.
Characterization of the surface topography and putative tertiary structure of the human CD7 molecule. (1989)

Abstract The CD7 gp40 molecule is a member of the Ig gene superfamily and is expressed on T cell precursors before their entry into the thymus during fetal development. N-terminal amino acids 1-107 of CD7 are highly homologous to Ig kappa-L chains whereas the carboxyl-terminal region of the extracellular domain of CD7 is proline-rich and has been postulated to form a stalk from which the Ig domain projects. To define potential functional regions of CD7, we have studied the surface topography of the CD7 Ag by synthesizing peptides corresponding to linear sequences within the CD7 extracellular domains, by raising polyclonal anti-CD7 rabbit sera against these peptides, and by computer analysis of the primary CD7 amino acid sequence. Polyclonal anti-CD7 sera were studied using indirect immunofluorescence, RIA, radioimmunoprecipitation, and Western blot assays. Computer analysis was performed comparing the CD7 sequence with all other known protein sequences. We found that three CD7 epitopes defined by peptides CD7-1A (AA 1-38), CD7-4 (AA 48-74), and CD7-7 (AA 129-146) were available for binding antibody on the surface of the CD7 molecule. Using computer analysis, we transposed the amino acid sequence of the CD7 Ig kappa-like N-terminal domain of CD7 onto the spatial coordinates of REI, a previously reported Ig kappa-molecule highly homologous (48%) to the CD7 N-terminal Ig-like region. Based on computer analysis of this putative CD7 three-dimensional structure, both the CD7-1A and CD7-4 regions protruded from the surface of the N-terminal domain of the CD7 molecule. Finally, comparison of the CD7 transmembrane sequence with CD4 and HIV transmembrane sequences and with respiratory syncytial virus fusion sequences demonstrated similar sequence motifs among these molecules.
DNA Triple Helices a Molecular Dynamics Study (1991)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation C. A. Laughton, S. Neidle; DNA Triple Helices a Molecular Dynamics Study. AIP Conf. Proc. 20 October 1991; 239 (1): 237. https://doi.org/10.1063/1.41360 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Prediction of motion induced magnetic fields for human brain MRI at 3 T (2023)

The proposed simulation strategy is able to predict movement-induced B<sub>0</sub> field inhomogeneities yielding more precise estimates of the ground truth field homogeneity than the transformed FM.
Chemical characterization of sediments and pore water from the upper Clark Fork river and milltown reservoir, Montana (1994)

Abstract The upper Clark Fork River basin in western Montana is widely contaminated by metals from past mining, milling, and smelting activities As part of a comprehensive ecological risk assessment for the upper Clark Fork River, we measured physical and chemical characteristics of surficial sediment samples that were collected from depositional zones for subsequent toxicity evaluations Sampling stations included five locations along the upper 200 km of the river, six locations in or near Milltown Reservoir (about 205 km from the river origin), and two tributary reference sites Concentrations of As, Cd, Cu, Mn, Pb, and Zn decreased from the upper stations to the downstream stations in the Clark Fork River but then increased in all Milltown Reservoir stations to levels similar to uppermost river stations Large percentages (50 to 90%) of the total Cd, Cu, Pb, and Zn were extractable by dilute (3 n) HCl for all samples Copper and zinc accounted for greater than 95% of extractable metals on a molar basis Acid-volatile sulfide (AVS) concentrations were typically moderate (0 6 to 23 μmol/g) in grab sediment samples and appeared to regulate dissolved (filterable) concentrations of Cd, Cu, and Zn in sediment pore waters Acid volatile sulfide is important in controlling metal solubility in the depositional areas of the Clark Fork River and should be monitored in any future studies Spatial variability within a sampling station was high for Cu, Zn, and AVS, therefore, the potential for toxicity to sediment dwelling organisms may be highly localized
Highly Accurate Measurement of LN Optical Intensity Modulators by Small RF Inputs (2007)

A highly accurate measurement method of parameters of MZ-type LN optical intensity modulators is presented. In this method, a CW optical signal is input to an optical terminal and small CW RF signal is applied to an electrode of the modulator. Then sideband levels of an output optical signal at different bias points are measured by using optical spectrum analyzer. By using 1st order sideband levels which are measured at two different bias conditions, and using a compensation method to measured levels, we can obtain accurate chirp parameter even when very small power of RF signal is applied to the modulator. In this method, the chirp parameter can be obtained in good accuracy when the input RF voltage is only 3% of the halfwave voltage.
Structure in the lowest absorption feature of CdSe quantum dots (1995)

We use transient differential absorption experiments to investigate the ‘‘single dot’’ absorption line shape of CdSe quantum dots. We observe both a narrow (full width half maximum ∼5 meV) and a broad (∼50 meV) bleach component within the inhomogeneously broadened first absorption line of our samples. We deduce the single dot absorption line shape which is most consistent with the experimental results. This line shape, which contains structure in the lowest quantum dot absorption feature, explains the large ‘‘Stokes’’ shift seen in the full band edge luminescence of CdSe quantum dots. We discuss the structure within the context of several competing models. The data appear inconsistent with models which use surface states to explain the anomalous emission behavior of II–VI quantum dots. Instead they imply that exciton fine structure is observed in our samples.
Serologic Response to Human Papillomavirus Type 16 (HPV-16) Virus-like Particles in HPV-16 DNA-Positive Invasive Cervical Cancer and Cervical Intraepithelial Neoplasia Grade III Patients and Controls from Colombia and Spain (1995)

A human papillomavirus (HPV) type 16 virus-like particle-based ELISA was used to assess antivirion immune responses in 300 women participating in cervical cancer case-control studies in Colombia and Spain. Virion IgG antibodies were detected in the sera of 51% and 59% of women with HPV-16 DNA-positive invasive cervical cancer and 81% and 73% of women with HPV-16 DNA-positive cervical intraepithelial neoplasia grade III (CIN III) in Colombia and Spain, respectively. Capsid antibodies were detected in 22% and 3% of cancer controls (P < .001) and in 43% and 10% of CIN III controls (P = .010) from Colombia and Spain, respectively. Since Colombia has an 8-fold higher incidence of cervical cancer, these results demonstrate an association between ELISA positivity and cancer risk. Capsid antibody responses did not correlate with humoral responses of the same women to HPV-16 E6 and E7 oncoproteins.
Bringing aerospace images into coincidence with subpixel accuracy by the local-correlation method (2004)

This paper proposes a local-correlation method that makes it possible to bring aerospace images into coincidence with subpixel accuracy after preliminary rough juxtaposition by transforming them relative to each other by uniform projective transformation and by additional mutual local displacements. The basis of the method is to establish a correspondence between the points of a pair of images by means of a phase correlation of individual segments of the images. The dissemination of information concerning measured shifts from reference points for which the correspondence has been found on a pair of images, as well as the use of analysis with variable spatial resolution, makes the method workable when the errors of the preliminary superposition are greater than the size of the correlation window. This paper presents the results of an experimental verification of the approach, using actual pairs of aerospace images as an example.© 2004 Optical Society of America
Use of Cassegrain System for in Situ Raman Scattering Study of Cyanide Ions on a Palladium Electrode (1993)

The nonenhanced Raman scattering spectra from CN ions adsorbed at the electrolyte/Pd electrode interface has been obtained with the use of a combination of a Cassegrain lens and a multichannel detector. Previously reported FT-IR spectra under similar conditions were used to help interpret the Raman-scattering results. The scattering results are explained on the basis of five bands assigned to the CN stretches. The position of these bands at 1950, 2060, 2090, 2150, and 2220 cm −1 are assigned to the covalent bond to a bridge site, covalent bond to an atop site, and ionic bond to Pd, Pd(CN) 4 2− , and Pd(CN) 2 . This study shows that it is possible to obtain an enhancement of about 10 3 by use of the Cassegrain system described here.
Combining modelling and mutagenesis studies of synaptic vesicle protein 2A to identify a series of residues involved in racetam binding (2011)

LEV (levetiracetam), an antiepileptic drug which possesses a unique profile in animal models of seizure and epilepsy, has as its unique binding site in brain, SV2A (synaptic vesicle protein 2A). Previous studies have used a chimaeric and site-specific mutagenesis approach to identify three residues in the putative tenth transmembrane helix of SV2A that, when mutated, alter binding of LEV and related racetam derivatives to SV2A. In the present paper, we report a combined modelling and mutagenesis study that successfully identifies another 11 residues in SV2A that appear to be involved in ligand binding. Sequence analysis and modelling of SV2A suggested residues equivalent to critical functional residues of other MFS (major facilitator superfamily) transporters. Alanine scanning of these and other SV2A residues resulted in the identification of residues affecting racetam binding, including Ile273 which differentiated between racetam analogues, when mutated to alanine. Integrating mutagenesis results with docking analysis led to the construction of a mutant in which six SV2A residues were replaced with corresponding SV2B residues. This mutant showed racetam ligand-binding affinity intermediate to the affinities observed for SV2A and SV2B.
Hydrogen-carbon-13 spin-spin coupling in transition metal hydride complexes (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHydrogen-carbon-13 spin-spin coupling in transition metal hydride complexesGeorge M. Whitesides and G. MaglioCite this: J. Am. Chem. Soc. 1969, 91, 18, 4980–4986Publication Date (Print):August 1, 1969Publication History Published online1 May 2002Published inissue 1 August 1969https://pubs.acs.org/doi/10.1021/ja01046a006https://doi.org/10.1021/ja01046a006research-articleACS PublicationsRequest reuse permissionsArticle Views193Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effects of tracking error on lesion formation in high intensity focused ultrasound liver tumor tracking treatments (2011)

High Intensity Focused Ultrasound (HIFU) liver tumor tracking treatments is a highly potential area of research. In order to develop a safe and effective HIFU liver tumor tracking treatment system, it is necessary to understand how tracking error affects lesion formation. In this paper, the relationship between the tracking error of the tracking mechanism and lesion formation is investigated through simulations and phantom experiments. Simulation and experimental results both show the lesion width first increases with increasing standard deviation of tracking error smaller than 1 mm, then decreases with increasing standard deviation of tracking error larger than 1 mm. On the other hand, the lesion length decreases with increasing standard deviation of the tracking error in all ranges. However, the lesion size still first increases with the tracking error standard deviation within 1 mm, then decreases when standard deviation of tracking lager than 1 mm. In another words, the lesion size is affected by the standard deviation of the tracking error as expected. Moreover, there exists an optimal lesion size around the standard deviation of 1 mm in our study. By taking the standard deviation of the tracking error into consideration, this study suggests that it is possible to develop a proper treatment plan without perfect tracking of the liver tumor.
A DNA SIZE PROBE BASED ON ENERGY MIGRATION IN CROSSLINKED CHROMATIN (2011)

DNA sizing has a central role in virtually every aspect of physical genomic analysis. Although capillary gel electrophoresis adequately separates DNA samples, accurate sizing of short sequences is problematic. Here we introduce a simple methodology that affords sizing of short DNA sequences at 2nt resolution via wrapping and linking histone subunits with fluorophore-tagged ssDNA to extract a wrapping and linking ratio that is unique to the reported DNA size.
Acoustic Noise Cancellation by Phase Alignment of Cooling Fans (2007)

With increasing power consumption of computer systems, faster and larger cooling fans are used and acoustic noise management becomes difficult. In this paper, we show that by locking a pair of cooling fan motors into a common frequency and 180 degrees out of phase, the dominant tone most perceptible by human ear can be reduced.
Influence of charged-dislocation density variations on carrier mobility in heteroepitaxial semiconductors: The case of SnO2on sapphire (2012)

In highly mismatched heteroepitaxial systems, the influence of carrier- and dislocation-density variations on carrier mobility is revealed. Transmission electron microscopy reveals the variation of dislocation density through a series of SnO${}_{2}$ films grown by molecular-beam epitaxy on sapphire substrates where the lattice mismatch exceeds 11$%$. A layer-by-layer parallel conduction treatment of the carrier mobility in SnO${}_{2}$ epilayers is used to illustrate the dominant role of the depth-dependent dislocation density and charge profile in determining the film-thickness dependence of the transport properties.