gebhart/patrepeval huggingface dataset:
Nexus-e: CentIv Module Documentation (2020)

Policy changes in the energy sector result in wide-ranging implications throughout the entire energy system and influence all sectors of the economy.Due partly to the high complexity of combining separate models, few attempts have been undertaken to model the interactions between the components of the energy-economic system.The Nexus-e Integrated Energy Systems Modeling Platform aims to fill this gap by providing an interdisciplinary framework of modules that are linked through well-defined interfaces to holistically analyze and understand the impacts of future developments in the energy system.This platform combines bottom-up and top-down energy modeling approaches to represent a much broader scope of the energy-economic system than traditional stand-alone modeling approaches.In Phase 1 of this project, the objective is to develop a novel tool for the analysis of the Swiss electricity system.This study illustrates the capabilities of Nexus-e in answering the crucial questions of how centralized and distributed flexibility technologies could be deployed in the Swiss electricity system and how they would impact the traditional operation of the system.The aim of the analysis is not policy advice, as some critical developments like the European net-zero emissions goal are not yet included in the scenarios, but rather to illustrate the unique capabilities of the Nexus-e modelling framework.To answer these questions, consistent technical representations of a wide spectrum of current and novel energy supply, demand, and storage technologies are needed as well as a thorough economic evaluation of different investment incentives and the impact investments have on the wider economy.Moreover, these aspects need to be combined with modeling of the long-and short-term electricity market structures and electricity networks.This report illustrates the capabilities of the Nexus-e platform.The Nexus-e Platform consists of five interlinked modules:1. General Equilibrium Module for Electricity (GemEl): a computable general equilibrium (CGE) module of the Swiss economy, 2. Centralized Investments Module (CentIv): a grid-constrained generation expansion planning (GEP)considering system flexibility requirements, 3. Distributed Investments Module (DistIv): a GEP module of distributed energy resources, 4. Electricity Market Module (eMark): a market-based dispatch module for determining generator production schedules and electricity market prices, 5. Network Security and Expansion Module (Cascades): a power system security assessment and transmission system expansion planning module.This report provides the description and documentation for the CentIv module, which is utilized in the Nexus-e framework to provide information regarding optimal investments in new generation and storage technologies at the transmission system level.
On the mesomorphism of hydrogen bonded complexes formed between decyloxystilbazole and phthalic acid (1996)

Abstract Further investigation of the mesomorphism of hydrogen bonded complexes formed between alkoxystilbazoles and benzenedicarboxylic acids has led to a reinterpretation of the phase behaviour. We have found unexpectedly that the most stable complex is at an equimolar ratio.
Nanophotonic Quantum Storage at Telecommunication Wavelength (2019)

Secure quantum communication over long distances is hindered by photon loss---a simple problem, complicated by the fact that quantum signals cannot be amplified without adding noise. The authors present on-chip quantum storage of light at telecommunication wavelength (around 1539 nm) for up to 10 $\ensuremath{\mu}$s, as an enabling technology for quantum repeater networks, which use distributed entanglement to overcome attenuation. High-fidelity quantum storage of light is demonstrated in a nanophotonic resonator fabricated in yttrium orthosilicate doped with erbium-167. Looking ahead, an improved resonator would yield a benchmark device on the way to scalable quantum communication networks.
Histopathological changes due to the effect of selenium in experimental cockerels. (2014)

The results of the present study suggested that the optimum dose of (140 μg/day) feeding induced atherogenesis by inflammation and smooth muscle proliferation in cockerels with experimentally induced hypercholesterolaemia.
Supplementary Tables 1-6 from Genome-Wide Interrogation of Human Cancers Identifies EGLN1 Dependency in Clear Cell Ovarian Cancers (2023)

&lt;p&gt;Supplementary Tables 1-6. Supplementary Table 1 contains a list of constructs used in this manuscript. Tab 2 with Supplementary table 2 is a list of all six-sigma genes we identified. Supplementary table 3 contains EGLN1 CRISPR Associations with mutations, gene expression, CRISPR dependencies and copy number. Supplementary table 4 contains EGLN1 RNAi Associations with mutations, gene expression, RNAi dependencies and copy number. Supplementary Table 5 contains all cell line information and annotations used for this manuscript. Supplementary Table 6 contains RNA sequence data from EGLN1 KO cells and EGLN1 WT cells.&lt;/p&gt;
What Is the Cardiac Impact of Chemotherapy and Subsequent Radiotherapy in Lymphoma Patients? (2019)

Anthracyclines are widely used in anticancer protocols, but can induce cardiotoxicity by mechanisms that mainly involve oxidative damage and mitochondrial dysfunction. Radiotherapy (RT) can also impair cardiac function by promoting myocardial fibrosis, microvascular damage, and decreased density of myocardial capillaries. Hence, we aim at investigating prospectively whether RT impacts heart function in lymphoma patients who had been already treated with anthracyclines. Twenty-nine consecutive patients with Hodgkin or non-Hodgkin lymphomas underwent echocardiography at baseline (before antineoplastic treatments), and then every 2 months, until 6 months after treatment completion. Echo evaluation included standard two-dimensional and speckle tracking. Twenty-two patients treated with anthracycline-based regimens were eligible. Out of the 22 patients, 8 received chemotherapy (CT) only (subgroup 1), while 14 underwent RT after CT [subgroup 2 (S2)]. At the end of CT, ejection fraction was significantly reduced in the whole population. At 6 months after completion of therapies, E/E' increased and global longitudinal strain was compromised in S2, suggesting additional damage induced by RT after CT. On the basis of the data from our small prospective study, we can hypothesize that in lymphoma patients, anthracyclines can worsen cardiac function, and RT may have an additional unfavorable myocardial impact.
Synthesis of Cyclopentenones from Cyclopropanes and Silyl Ynol Ethers (2008)

Ringöffnung und Ringschluss: Die Ringöffnung Donor-Akzeptor-substituierter Cyclopropane durch Lewis-Säuren erzeugt 1,3-Zwitterionen, die durch Cycloadditionen mit Silylinolethern Cyclopentenone zugänglich machen (siehe Schema). Am Inol und an allen Positionen des Cyclopropans können Substituenten vorliegen, sodass drei-, vier- und fünffach substituierte Cyclopentenone in hohen Ausbeuten erhalten werden. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2008/z801957_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Fast Graph Algorithms for Superpixel Segmentation (2022)

We introduce the novel graph-based algorithm SLAM (simultaneous local assortative mixing) for fast and high-quality superpixel segmentation of any large color image. Super-pixels are compact semantic image elements; superpixel segmen-tation is fundamental to a broad range of vision tasks in existing and emerging applications, especially, to safety-critical and time-critical applications. SLAM leverages a graph representation of the image, which encodes the pixel features and similarities, for its rich potential in implicit feature transformation and extra means for feature differentiation and association at multiple resolution scales. We demonstrate, with our experimental results on 500 benchmark images, that SLAM outperforms the state-of-art algorithms in superpixel quality, by multiple measures, within the same time frame. The contributions are at least two-fold: SLAM breaks down the long-standing speed barriers in graph-based algorithms for superpixel segmentation; it lifts the fundamental limitations in the feature-point-based algorithms.
P3‐047: The Amyloid‐Beta (Aβ) Oligomer‐Specific CYCLIC‐SER‐ASN‐LYS (CSNK) Tripeptide is Highly Immunogenic and Induces Sustained Levels of ANTI‐CSNK Antibodies of the IGG1 Subclass (2016)

Amyloid beta Oligomers (AβO) are key mediators of the neurotoxic, neuropathologic and behavioral changes characteristic of Alzheimer’s Disease (AD). We identified an AβO-specific epitope, cyclized serine-asparagine-lysine (cSNK), and generated mouse monoclonal antibody 5E3 (mAb5E3) and a humanized version (h5E3) targeting this epitope. We have demonstrated the specificity and selectivity of mAb5E3 for soluble synthetic and native AβOs, and its non-reactivity with monomers and fibrils. Consequently, APP/PS1 mice immunized with cSNK generated AβO-specific antibodies with concomitant decreases in plaque burden, reduced amyloid propagation and ameliorated memory deficits. In continuance with developing the cSNK tripeptide as a potential vaccine, our current work further elucidates key attributes of the humoral immune response in cSNK-immunized mice: long-term temporal profile and immunoglobulin (Ig) isotype/subclass distribution. The study consisted of 76 sex-matched APP/PS1 mice, 38 vaccinated with 100 μg of cSNK-KLH/ Emulsigen-D adjuvant, and 38 with adjuvant only beginning at 3 months of age. Animals were thereafter treated monthly for 12 months and plasma collected prior to each immunization. Anti-cSNK antibodies were detected using a Molecular Affinity Screening System (MASS-1) (Sierra Sensors, Germany), a high throughput surface plasmon resonance imaging analytical biosensor. cSNK-BSA was immobilized on a sensorchip and serial samples of all mice injected. In a subsequent experiment, the Ig isotype/subclass distribution of serial samples of 20 mice were evaluated: diluted plasma were injected, followed by injections of goat anti-mouse IgA, IgM, IgG, IgG1, IgG2a, IgG2ab, IgG2c and IgG3. Adjuvant-treated mice had no detectable antibodies to cSNK, whilst all cSNK-immunized mice generated high levels of anti-cSNK antibodies commencing at 4 weeks post-vaccination, age month 4. Peak antibody levels were attained at 8 weeks post-vaccination, age month 5, after which levels varied and declined slightly but remained substantially higher than levels at month 4. Ig isotype/ subclass analysis revealed that anti-cSNK antibodies are overwhelmingly of the IgG isotype and predominantly of the IgG1 subclass. Immunization of APP/PS1 mice with the cSNK tripeptide induces high and sustained levels of anti-cSNK antibodies that demonstrated binding to AβO. Anti-cSNK antibodies are predominantly of the IgG1 isotype, this being indicative of a Th2 immune response.
Structure‐Function Correlation of G6, a Novel Small Molecule Inhibitor of Jak2: Indispensability of the Stilbenoid Core (2010)

Somatic mutations in the Jak2 allele, such as V617F, cause aberrant Jak‐STAT signalling and can lead to the development of myeloproliferative neoplasms (MPNs). This has led to the search for small molecule inhibitors that target Jak2. Using structure‐based virtual screening, our lab recently identified a novel small molecule inhibitor of Jak2 named G6. Here, we identified a structure‐function correlation of this compound. Specifically, five derivative compounds of G6 having structural similarity to the original lead compound were analyzed for their ability to i) inhibit Jak2‐V617F mediated cell growth ii) inhibit the levels of phospho‐Jak2, phospho‐STAT3 and phospho‐STAT5 iii) induce apoptosis in HEL cells and iv) suppress pathologic cell growth of Jak2‐V617F expressing human bone marrow cells, ex vivo . Additionally, we examined the interactions of these compounds with the ATP binding pocket of the Jak2 kinase domain. We found that the stilbenoid core containing derivatives of G6 significantly inhibited Jak2‐V617F mediated cell proliferation in a time‐ and dose‐dependent manner. They also inhibited phosphorylation of Jak2, STAT3 and STAT5 proteins within cells. Moreover, we report that these stilbenoid derivatives of G6 induced apoptosis and inhibited the pathologic growth of Jak2‐V617F expressing human bone marrow cells, ex vivo . Collectively, our data demonstrate that G6 has a core stilbene structural element which is indispensable for maintaining its Jak2 inhibitory potential. Supported by R01‐HL67277.
Identification of a Novel Francisella tularensis Factor Required for Intramacrophage Survival and Subversion of Innate Immune Response (2012)

Francisella tularensis, the causative agent of tularemia, is one of the deadliest agents of biological warfare and bioterrorism. Extremely high virulence of this bacterium is associated with its ability to dampen or subvert host innate immune response. The objectives of this study were to identify factors and understand the mechanisms of host innate immune evasion by F. tularensis. We identified and explored the pathogenic role of a mutant interrupted at gene locus FTL_0325, which encodes an OmpA-like protein. Our results establish a pathogenic role of FTL_0325 and its ortholog FTT0831c in the virulent F. tularensis SchuS4 strain in intramacrophage survival and suppression of proinflammatory cytokine responses. This study provides mechanistic evidence that the suppressive effects on innate immune responses are due specifically to these proteins and that FTL_0325 and FTT0831c mediate immune subversion by interfering with NF-κB signaling. Furthermore, FTT0831c inhibits NF-κB activity primarily by preventing the nuclear translocation of p65 subunit. Collectively, this study reports a novel F. tularensis factor that is required for innate immune subversion caused by this deadly bacterium.
The discovery and development of rivaroxaban (2011)

Thromboembolic conditions present a considerable challenge to healthcare services because they are associated with substantial morbidity and mortality. The mainstays of prevention and treatment are anticoagulants and antiplatelet agents. Established anticoagulants have drawbacks that make their use difficult to manage and sustain. This has stimulated the search for new oral anticoagulants that are more convenient and yet still effective. This paper describes the development and future potential of rivaroxaban (Xarelto; Bayer Schering Pharma AG, Berlin, Germany)-the first oral, direct Factor Xa inhibitor to be approved for clinical use in the prevention of venous thromboembolism in adult patients undergoing elective hip or knee replacement surgery.
Local Structural Elements in the Mostly Unstructured Transcriptional Activation Domain of Human p53 (2000)

DNA transcription is initiated by a small regulatory region of transactivators known as the transactivation domain. In contrast to the rapid progress made on the functional aspect of this promiscuous domain, its structural feature is still poorly characterized. Here, our multidimensional NMR study reveals that an unbound full-length p53 transactivation domain, although similar to the recently discovered group of loosely folded proteins in that it does not have tertiary structure, is nevertheless populated by an amphipathic helix and two nascent turns. The helix is formed by residues Thr(18)-Leu(26) (Thr-Phe-Ser-Asp-Leu-Trp-Lys-Leu-Leu), whereas the two turns are formed by residues Met(40)-Met(44) and Asp(48)-Trp(53), respectively. It is remarkable that these local secondary structures are selectively formed by functionally critical and positionally conserved hydrophobic residues present in several acidic transactivation domains. This observation suggests that such local structures are general features of acidic transactivation domains and may represent "specificity determinants" (Ptashne, M., and Gann, A. A. F. (1997), Nature 386, 569-577) that are important for transcriptional activity.
Constrained complexity spatio-temporal interference rejection combining (2003)

Space-time processing for co-channel interference (CCI) rejection and equalization with antenna arrays may provide large gains over space-only processing, especially in interference limited scenarios. However, taking the temporal correlation of the noise and CCI process into account leads to sequence detection with higher complexity as compared to space-only processing that neglects this correlation. We propose the use of the generalized Viterbi algorithm for sequence detection with lower complexity. Special cases include the M-algorithm and the delayed decision feedback sequence estimator. A relevant comparison between spatial and spatio-temporal processing with sequence detectors of the same complexity may thus be performed. Numerical examples show substantial gains for spatio-temporal processing as compared to space-only processing also in this case when the optimality of the sequence detector is traded for interference rejection.
Photochromism of [2.n]Metacyclophan-1-ene Derivatives (1988)

Abstract Photochromism of [2.n]metacyclophan-1-ene derivatives (n=2,3,4) was investigated. The reaction rates of the thermal decoloration were increased about thousand-fold with increasing of n by one.
New C-protective group for peptide synthesis (2009)

To investigate the possibility of using the 2-(1-adamantyl)-2-propyl (Adp) ester group for carboxyl protection during peptide synthesis, the tetrapeptide Boc-Phe-Arg(NO2)-Phe-Pro-OAdp (IV) was prepared by the carbodiimide method. In this synthesis the Z group was removed by transfer hydrogenation and the Nps group by treatment with 2-thiopyridone. The Adp group was then cleaved with 3% TFA/DCM, yielding Boc-Phe-Arg(NO2)-Phe-Pro-OH. For subsequent kinetics studies the decapeptide Boc-Leu--Z-Orn-Arg(NO2)-Pro- Pro-Gly-Phe-Ser(Bzl)-Pro-Pro-OAdp (VIII) was synthesized by a 9 + 1 scheme. This peptide was also selectively deblocked. Comparing reaction abilities of Z-Pro-OAdp and Z-Pro-OBut, it was demonstrated that the Adp ester is cleaved by 3% TFA/DCM 230 times faster than the Bu(t) ester. For peptides IV and VIII the ratios between the rates of competitive elimination of the Adp and Boc groups by 3% TFA/DCM are 19 and 64, respectively.
Stimulus energy does not account for 2-month-olds' face preferences. (1987)

We examined the determinants of 2-month-olds' preferences among facelike and abstract patterns. Observed preferences were compared with the predictions of two preference models--one based on stimulus energy (as measured by the amplitude spectrum) and the other based on stimulus structure (as measured by the phase spectrum). It is known that the phase spectrum is the primary determinant of perceived identity to adults. Twenty-five 2-month-olds saw six pairings of four patterns: a schematic face, a lattice, a pattern composed of the amplitude spectrum of the lattice and the phase spectrum of the face, and a pattern composed of the amplitude spectrum of the face and the phase spectrum of the lattice. Only patterns with the face's phase spectrum look facelike to adults. Unlike the preferences of newborns (Kleiner, 1987), 2-month-olds' preferences could be predicted from the phase spectrum but not from the amplitude spectrum. In other words, the 2-month-olds preferred the patterns that looked facelike to adults. These results offer clear evidence that 2-month-olds' preferences for facelike patterns are not governed by stimulus energy.
A study on the stabilization of the van der Pol limit cycle (2004)

The classical Van der Pol equation is investigated with the goal of stabilizing the well-known limit cycle with only a linear feedback controller. This result is demonstrated in this paper through a five-step process. The stabilization is global in the sense that, with the appropriate controller, the origin now becomes a stable equilibrium point for initial starting points both inside and outside the region, which would normally produce the oscillatory behavior. The technique is outlined in detail sufficient to generalize to other applications that arise in certain classes of nonlinear systems.
Alterations of Transmembrane Currents in Frog Atrial Heart Muscle Induced by Photoexcited Gymnochrome A Purified from the Crinoid, Gymnochrinus richeri (2001)

The effects of gymnochrome A were tested on the electrical activity of the frog atrial heart muscle. Gymnochrome A (1-5 microM) did not alter the resting potential. Gymnochrome A (5 microM) slowed the initial depolarizing phase of the spontaneously beating action potential. Under voltage-clamp conditions gymnochrome A (5 microM) did not affect the electrical constant of the membrane and the kinetic parameters of the peak Na+ current (INa) recorded in the Ringer solution containing tetraethylammonium (2 mM) and Cd2+ (1 mM) but shifted the membrane potential at which the current both activated and reached its maximal value toward more negative membrane potentials. It did not alter the reversal potential for INa, indicating that the selectivity of the Na+ channels had not changed. These observations suggest that gymnochrome A binds to the membrane and shifts the activation of INa on the voltage axis by modifying the free negative fixed charges present at the membrane surface rather than by occupying a specific site on the Na+ channel. Photoexcited gymnochrome A transiently triggered an early outward current which lengthened the time-to-peak of INa and decreased its amplitude. In addition, photoexcited gymnochrome A blocked the background K+ current. This is, to our knowledge, the first time that such effects are reported on the cardiac muscle. These observations suggest that the photoexcitation of gymnochrome produces physico-chemical effects which lead to intracellular changes. Further experiments are required to determine their nature.
Energy-efficient colourless photonic technologies for next-generation DWDM metro and access networks (2012)

Within the scope of our EU FP7 C3PO project, we are developing novel, energy-efficient, colourless photonic technologies for low-cost, next-generation dense wavelength-division-multiplexed metro transport and access networks. The colourless transmitters use reflective arrayed photonic integrated circuits, particularly hybrid reflective electroabsorption modulators, and multi-wavelength laser sources, with custom power-efficient driver circuitry. A low-loss piezoelectric beam-steering optical matrix switch allows for dynamic wavelength reconfigurability. Simplifying the required optical and electronic hardware, as well as avoiding the need for expensive, thermally-stabilised tuneable lasers, will yield cost and energy savings for data switching applications in future metro, access, and datacentre interconnection networks. We report on recent advancement towards these low-power optical networks, providing the latest systems results achieved with key enabling hybrid photonic integrated devices and electronic driver/receiver arrays for our targeted applications.
Supplementary Figure 2 from Collaboration of Kras and Androgen Receptor Signaling Stimulates EZH2 Expression and Tumor-Propagating Cells in Prostate Cancer (2023)

&lt;p&gt;PDF file, 157K, IHC analysis of regenerated tissues.&lt;/p&gt;
Nonrandom Mating in Feral Pigeons (1989)

Feral pigeons (Columba livia) showed two sorts of nonrandom mating: size-based assortative mating and plumage-based disassortative mating. Size-based mating was evident in that individuals of like sizes were paired; such mating was presumably based on perception of size or a size-correlated variable, such as social dominance rank, by both sexes. Plumage-based pairing was evident in that individuals of unlike plumages were bonded; this was based on perception of unlike plumage patterns, probably by females. Both size-based and plumage-based pairing influenced reproductive output.