gebhart/patrepeval huggingface dataset:
Rational Ligand Design of Heteroleptic Iridium (III) Complexes toward Nearly Perfect Horizontal Dipole Orientation for Highly Efficient Red‐Emitting Phosphorescent Organic Light‐Emitting Diodes (2023)

Abstract The horizontal orientation of the transition dipole moment of the phosphorescent emitters is understood to be an important factor to enhance the external quantum efficiency (EQE) of organic light‐emitting diodes by improving light out‐coupling in optical microcavity structures. Here, red‐emitting heteroleptic iridium (III) complexes exhibiting an extremely high horizontal ratio of emitting dipole orientation (EDO) and photoluminescence quantum yield (PLQY), as well as longer device operational lifetime, without scarifying any other photophysical properties are reported. The systematic molecular design of main and ancillary ligands in heteroleptic iridium complexes leads to the achievement of both a horizontal EDO of 92% and a PLQY of 98% in the red‐emitting phosphorescent devices along with a shorter exciton decay time of 0.71 µs. Accordingly, the red‐emitting devices show excellent performances of maximum EQE of 32% and low‐efficiency roll‐off with the 1931 Commission Internationale de L′Eclariage coordinates of (0.66, 0.34). Therefore, this approach opens the way for further development of new red‐emitting iridium complexes pushing the device efficiency toward the theoretical limits.
A Multiport Bidirectional LLC Resonant Converter for Grid-Tied Photovoltaic-Battery Hybrid System (2019)

Bidirectional LLC resonant converters are becoming increasingly more attractive in grid-connected applications with integrated photovoltaic (PV) systems and energy storage systems (ESS). In this study, a multiport bidirectional LLC resonant converter for grid-tied systems is proposed. In addition, a region based control schema with a modified maximum power point tracking (MMPPT) control derived from the incremental conductance method is introduced to control both the forward (discharge mode) and backward (charge mode) operation of the proposed converter. The proposed topology consists of an integrated bidirectional converter for the battery system, a bidirectional LLC resonant converter, a voltage source inverter for grid-tied operation and the PV system. The proposed topology is modelled with MATLAB/Simulink and validated for different operation conditions.
Duration expansion of wavelength-to-time mapping based on a programmable dispersion loop (2017)

A novel scheme is proposed to extend the pulse duration based on a programmable dispersion loop. The repetition period is 1024-fold increased by a magneto-optic switch and the duration is recirculated by 50 times.
Variation of Des-Gamma-Carboxyprothrombin (PIVKA-II) Levels in Cord Blood Throughout Gestation (2001)

The variation of des-gamma-carboxyprothrombin (PIVKA-II, protein induced by vitamin K absence) levels in umbilical cord blood throughout gestation was examined using a highly sensitive method, electrochemiluminescence immunoassay (ECLIA). PIVKA-II levels in infants without any complications were low, but modestly high, exceeding the normal range of healthy adults during the preterm period, followed by a remarkable increase after the 37th week of gestation. Among infants complicated with severe preeclampsia a marked increase of PIVKA-II levels was observed in preterm infants, showing a good correlation with the existence ofinfarctions on the placenta. On the other hand, among infants complicated with preterm premature rupture of the membranes (PROM) in which antibiotics were administered during the prenatal period, a moderate elevation of PIVKA-II levels was observed. These data suggest that the normal range of PIVKA-II in fetuses is modestly high compared with adults and any deficient status of vitamin K would not exist throughout the preterm period. Nevertheless, the vitamin K status might readily fall into a deficient condition in term infants. Furthermore, it is notable that vitamin K deficiency would be induced in complicated gestation with severe preeclampsia and medication with antibiotics.
Modeling Coke Distribution above the Freeboard of a FLUID COKING Reactor (2012)

In a FLUID COKING unit, reactor cyclone fouling by coke deposits can set the run length of the unit. Over time the coke deposits can grow and obstruct the cyclone which will limit throughput and lead to a shutdown. For this reason, producing a more uniform coke distribution pattern within the reactor horn chamber may lead to an increased interval between turnarounds. An existing pilot-scale experimental model of the coker reactor freeboard, horn chamber, and exit cyclones allows determination of coke distribution to the cyclones, but provides limited understanding of the underlying fluid dynamics within the system. In this work a two-phase computational fluid dynamics (CFD) model of this experimental rig was developed. Coke was modeled as an Eulerian stream of solid particles with monodisperse particle diameter. It was found that predicted coke distributions were sensitive to the choice of coke diameter, but a suitable choice gave good agreement with experimental observations. In the current work this value was 167 μm which was substantially higher than the value of the Sauter mean diameter of 139 μm. It was found that the CFD model could quantitatively predict coke distributions in the freeboard region of a FLUID COKING reactor experimental rig, while providing insight into the flow dynamics. When modeling the particle size distribution with a monodisperse particle diameter, comparison with experimental results is necessary to identify the coke particle diameter that leads to optimal model performance.
Low-Power Instrument Transformers and Energy Meters: Opportunities and Obstacles (2023)

Low-Power Instrument Transformers (LPITs) are becoming the preferred measurement device in the medium voltage (MV) distribution network (DN). They have several benefits compared to legacy solutions. However, the adoption of LPITs results in the need for adapting the grid and its assets to accept them. One practical example is using LPITs as the current and voltage source for energy meters (EMs), which are also used for billing purposes. The resulting measurement chain introduces several metrological challenges that must be studied and investigated. Therefore, in this work, the scenarios of LPITs and energy meters are introduced along with the latest relevant international standards. Afterwards, the opportunities and obstacles due to the implementation of the LPIT plus energy meter measurement chain are discussed. The discussion focuses on metrological requirements, accuracy evaluation, target uncertainty, and influence quantities affecting the performance of the devices.
Variable width splines: a possible font representation? (1993)

this paper. Advantages include a good first step toward typographic scaling (stroke width scales independently of overall scale factor), and preservation of topology at low resolutions (minimum stroke width can be enforced). A chief disadvantage is the lack of experience designing fonts in this paradigm, or building routines to convert from other paradigms.
Upcycling spent petroleum cracking catalyst: pulsed laser deposition of single-wall carbon nanotubes and silica nanowires (2016)

From waste to single-wall carbon nanotubes and silica nanowires: the first high-tech outlet for FC3R.
A Simple and Versatile Synthetic Strategy to Functional Polypeptides via Vinyl Sulfone-Substituted l-Cysteine N-Carboxyanhydride (2013)

Vinyl sulfone-substituted l-cysteine N-carboxyanhydride (VSCys-NCA) monomer was designed and developed to afford a novel and versatile family of vinyl sulfone (VS)-functionalized polypeptides, which further offer a facile access to functional polypeptide-based materials including glycopolypeptides, functional polypeptide coatings, and in situ forming polypeptide hydrogels through Michael-type addition chemistry under mild conditions. VSCys-NCA was obtained in two straightforward steps with a high overall yield of 76%. The copolymerization of γ-benzyl l-glutamate NCA (BLG-NCA), N-benzyloxycarbonyl-l-lysine NCA (ZLL-NCA), or l-leucine NCA (Leu-NCA) with VSCys-NCA using 1,1,1-trimethyl-N-2-propenylsilanamine (TMPS) as an initiator proceeded smoothly in DMF at 40 °C, yielding P(BLG-co-VSCys), P(ZLL-co-VSCys), or P(Leu-co-VSCys) with defined functionalities, controlled molecular weights, and moderate polydispersities (PDI = 1.15–1.50). The acidic deprotection of P(BLG-co-VSCys) and P(ZLL-co-VSCys) furnished water-soluble VS-functionalized poly(l-glutamic acid) (P(Glu-co-VSCys)) and VS-functionalized poly(l-lysine) (P(LL-co-VSCys)), respectively. These VS-functionalized polypeptides were amenable to direct, efficient, and selective postpolymerization modification with varying thiol-containing molecules such as 2-mercaptoethanol, 2-mercaptoethylamine hydrochloride, l-cysteine, and thiolated galactose providing functional polypeptides containing pendant hydroxyl, amine, amino acid, and saccharide, respectively. The contact angle and fluorescence measurements indicated that polymer coatings based on P(Leu-co-VSCys) allowed direct functionalization with thiol-containing molecules under aqueous conditions. Moreover, hydrogels formed in situ upon mixing aqueous solutions of P(Glu-co-VSCys) and thiolated glycol chitosan at 37 °C. These vinyl sulfone-functionalized polypeptides have opened a new avenue to a broad range of advanced polypeptide-based materials.
ChemInform Abstract: Bi(OTf)3‐Catalyzed Solvent‐Free Synthesis of Pyrano[3,2‐c]coumarins Through a Tandem Addition/Annulation Reaction Between Chalcones and 4‐Hydroxycoumarins. (2013)

Abstract The title reaction is a cost‐effective and environmentally benign method which produces water as the only side product.
An Experimental Method for Evaluating Film Persistency (1987)

Abstract An electrochemical laboratory technique is presented for the evaluation of film persistency under high-speed fluid flow. The experimental system involves a disk electrode immersed in electrolyte and subjected to an axisymmetric impinging jet of the same electrolyte. Ring-electrode experiments were used to determine the value of the hydrodynamic shear and to identify the geometric constraints under which the shear stress on the electrode surface is a linear function of radial position. The geometric constraints obtained were tighter than previously reported results. With the proper experimental design. the critical shear for removal of a protective film can be obtained by measuring the profile of an electrode subjected to a given jet velocity. This technique is illustrated for evaluation of a commercial inhibitor in chloride solutions.
Leadership in Orthopaedic Surgery: Creating a Highly Effective Leader. (2023)

Strong leadership is associated with improved outcomes in multiple domains, including orthopaedic surgery. There are multiple leadership styles, including transformational, transactional, and laissez-faire leadership. An effective leader understands the importance of verbal and nonverbal communication, emotional intelligence, preparation, and mindset on team performance. Orthopaedic surgeons serve as leaders in the operating room, in the outpatient setting, and on committees. Leadership skills can be developed through leadership-specific evaluations and training.
Fluorescein based optical detection of oral pH (Conference Presentation) (2019)

We have developed a new tool to measure the acid production by plaque oral bacteria. Many species of oral bacteria metabolize sugars in food and produce organic acids that demineralize the dental enamel leading to the formation of cavities. Measuring the acidity level before and after a sugar rinse can indicate the susceptibility of an individual to tooth decay and location of active caries. In a case study on two subjects, a non-contact optics-based pH device was able to track pH before and after a sugar rinse. The fiber optic probe measures acidity level in difficult to access dental locations such as occlusal pits and fissures based on changes in the spectral fluorescence profile of fluorescein (FL) dye. Fiber coupled 420 nm LED excites 200uM aqueous FL solution in the mouth. The fluorescence spectrum in 450-650 nm range is obtained using an adjacent fiber optic cable coupled to a spectrometer. Chemometric analysis of endmember dianion and anion species using least-square fitting is performed to determine the pH of the FL absorbed into the extracellular region of the oral biofilm. Other unwanted noise, like background light and auto-fluorescence in the range of 450-650 nm is removed before calculating biofilm pH. Using this device in a darkened room on two subjects, we were able to measure resting pH (before a sugar rinse) and track time dependent change in pH (after a sugar rinse) in the range of pH 4-7 paving the way for first clinical optical pH measurement in the mouth.
Ion-gated transistors based on porous and compact TiO2 films: Effect of Li ions in the gating medium (2020)

Ion-gated transistors (IGTs) are attractive for chemo- and bio-sensing, wearable electronics, and bioelectronics, because of their ability to act as ion/electron converters and their low operating voltages (e.g., below 1 V). Metal oxides are of special interest as transistor channel materials in IGTs due to their high mobility, chemical stability, and the ease of processing in air at relatively low temperatures (&amp;lt;350 °C). Titanium dioxide is an abundant material that can be used as a channel material in n-type IGTs. In this work, we investigate the role of the morphology of the TiO2 channel (porous vs compact films) and the size of the cations in the gating media ([EMIM][TFSI] and [Li][TFSI] dissolved in [EMIM][TFSI]) to study their role on the electrical characteristics of IGTs. We found that both the film morphology and the type of gating medium highly affect the electrical response of the devices.
Ultrafast Spectroscopy and Computational Study of the Photochemistry of Diphenylphosphoryl Azide: Direct Spectroscopic Observation of a Singlet Phosphorylnitrene (2011)

The photochemistry of diphenylphosphoryl azide was studied by femtosecond transient absorption spectroscopy, by chemical analysis of light-induced reaction products, and by RI-CC2/TZVP and TD-B3LYP/TZVP computational methods. Theoretical methods predicted two possible mechanisms for singlet diphenylphosphorylnitrene formation from the photoexcited phosphoryl azide. (i) Energy transfer from the (π,π*) singlet excited state, localized on a phenyl ring, to the azide moiety, thereby leading to the formation of the singlet excited azide, which subsequently loses molecular nitrogen to form the singlet diphenylphosphorylnitrene. (ii) Direct irradiation of the azide moiety to form an excited singlet state of the azide, which in turn loses molecular nitrogen to form the singlet diphenylphosphorylnitrene. Two transient species were observed upon ultrafast photolysis (260 nm) of diphenylphosphoryl azide. The first transient absorption, centered at 430 nm (lifetime (τ) ∼ 28 ps), was assigned to a (π,π*) singlet S&lt;sub&gt;1&lt;/sub&gt; excited state localized on a phenyl ring, and the second transient observed at 525 nm (τ ∼ 480 ps) was assigned to singlet diphenylphosphorylnitrene. Experimental and computational results obtained from the study of diphenyl phosphoramidate, along with the results obtained with diphenylphosphoryl azide, supported the mechanism of energy transfer from the singlet excited phenyl ring to the azide moiety, followed by nitrogen extrusion to form the singlet phosphorylnitrene. Ultrafast time-resolved studies performed on diphenylphosphoryl azide with the singlet nitrene quencher, tris(trimethylsilyl)silane, confirmed the spectroscopic assignment of singlet diphenylphosphorylnitrene to the 525 nm absorption band.
Plasma pharmaeokineties of the antitumour agents 5,6-dimethylxanthenone-4-acetic acid, xanthenone-4-acetic acid and flavone-8-acetic acid in mice* (1991)

Summary. Although the antitumour agent flavone-8acetic acid (FAA) exhibits remarkable activity against murine solid tumours, its clinical use has a number of pharmacological drawbacks, including low dose potency and dose-dependent pharmacokinetics. Xanthenone-4acetic acid (XAA) and its 5,6-dimethyl derivative (5,6MeXAA) were synthesised during a search for better analogues of FAA. The maximal tolerated doses (MTDs) of 5,6-MeXAA, XAA and FAA in BDF1 mice were 99, 1,090 and 1,300 ~tmol/kg, respectively. At the MTD, 5,6MeXAA displayed the following pharmacokinetic properties: maximal plasma concentration, 600 ~LM; mean residence time, 4.9 h; AUC, 2,400 gmol h 1-1; and volume of steady-state distribution, 0.2 1/kg. All compounds displayed nonlinear elimination kinetics at the MTD, but when the logarithm of the AUC was plotted against that of the delivered dose, the slope of the regression line for 5,6-MeXAA was found to be 1.2 as opposed to 1.4 for XAA and 1.98 for FAA. 5,6-MeXAA thus showed only a slight deviation from dose-independent kinetics. 5,6MeXAA bound to plasma proteins in a manner similar to that exhibited by FAA, although the plasma concentration of free drug was lower for the former than for the latter. As a consequence, the calculated maximal free drug concentration for 5,6-MeXAA in plasma was 23 times lower than that for FAA.
The A BC o f S olute C arriers (2004)

The SLC22 family comprises organic cation transporters (OCTs), zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). These transporters contain 12 predicted a-helical transmem- brane domains (TMDs) and one large extracellular loop between TMDs 1 and 2. Transporters of the SLC22 family function in different ways: (1) as uniporters that mediate facilitated diffusion in either direction (OCTs), (2) as anion exchangers (OAT1, OAT3 and URAT1), and (3) as Na + /l-carnitine cotransporter (OCTN2). They participate in the absorption and/or excretion of drugs, xenobiotics, and endogenous compounds in intestine, liver and/or kidney, and perform homeostatic functions in brain and heart. The endogenous substrates include monoamine neurotransmitters, choline, l-carnitine, a- ketoglutarate, cAMP, cGMP, prostaglandins, and urate. Defect mutations of transporters of the SLC22 family may cause specific diseases such as primary systemic carni- tine deficiency or idiopathic renal hypouricemia or change drug absorption or excretion.
Involvement of reactive oxygen intermediates in the induction of c-jun gene transcription by ionizing radiation. [Erratum to document cited CA117(15):146279d] (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleInvolvement of reactive oxygen intermediates in the induction of c-jun gene transcription by ionizing radiation. [Erratum to document cited CA117(15):146279d]Rakesh Datta, Dennis E. Hallahan, Surender M. Kharbanda, Eric Rubin, Matthew L. Sherman, Eliezer Huberman, Ralph R. Weichselbaum, and Donald W. KufeCite this: Biochemistry 1992, 31, 39, 9512Publication Date (Print):October 1, 1992Publication History Published online1 May 2002Published inissue 1 October 1992https://pubs.acs.org/doi/10.1021/bi00154a025https://doi.org/10.1021/bi00154a025research-articleACS PublicationsRequest reuse permissionsArticle Views13Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Isolation and characterization of porcine diazepam‐binding inhibitor, a polypeptide not only of cerebral occurrence but also common in intestinal tissues and with effects on regulation of insulin release (1988)

The polypeptide DBI (diazepam-binding inhibitor) has been purified from the porcine upper intestine, where it is abundant. Porcine mature DBI is composed of 86 amino acid residues and has a blocked N-terminus. The primary structure, the first DBI structure determined at the protein level, differs from those indirectly deduced for human and rat DBI at 11 and 17 positions, respectively. In total, the three mammalian DBIs differ at 22 positions but have exactly identical C-terminal 11-residue segments, highly charged and ending with C-terminal isoleucine. The porcine DBI inhibits both the early and the late phase of glucose-induced insulin release from the isolated perfused rat pancreas. Thus, the results identify by direct analysis the presence of DBI at a non-cerebral localization (gut), establish a novel structural form (porcine) and demonstrate a novel bioactivity (on insulin release). These aspects are of special interest in relation to the conserved segments, including the one at the C-terminal end, which may constitute functionally important parts of the polypeptide. It is possible that DBI belongs to a new family of gut polypeptides which inhibit glucose-mediated insulin release by hormonal and/or neurocrine mechanisms.
How standardization of the pre-analytical phase of both research and diagnostic biomaterials can increase reproducibility of biomedical research and diagnostics (2019)

Comparison of published biomedical studies shows that a large proportion are irreproducible, causing severe damage to society and creating an image of wasted investments. These observations are of course damaging to the biomedical research field, which is currently full of future promise. Precision medicine and disease prevention are successful, but are progressing slowly due to irreproducible study results. Although standardization is mentioned as a possible solution, it is not always clear how this could decrease or prevent irreproducible results in biomedical studies. In this article more insight is given into what quality, norms, standardization, certification, accreditation and optimized infrastructure can accomplish to reveal causes of irreproducibility and increase reproducibility when collecting biomaterials. CEN and ISO standards for the sample pre-analytical phase are currently being developed with the support of the SPIDIA4P project, and their role in increasing reproducibility in both biomedical research and diagnostics is demonstrated. In particular, it is described how standardized methods and quality assurance documentation can be exploited as tools for: 1) recognition and rejection of 'not fit for purpose' samples on the basis of detailed sample metadata, and 2) identification of methods that contribute to irreproducibility which can be adapted or replaced.