gebhart/patrepeval huggingface dataset:
Stereochemistry of Erysulfone (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereochemistry of ErysulfoneDavid M. Piatak, Pui-Fun L. Tang, Jeff Franciskovich, and Robin D. RogersCite this: J. Nat. Prod. 1991, 54, 3, 902–904Publication Date (Print):May 1, 1991Publication History Published online1 July 2004Published inissue 1 May 1991https://pubs.acs.org/doi/10.1021/np50075a030https://doi.org/10.1021/np50075a030research-articleACS PublicationsRequest reuse permissionsArticle Views50Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Thermal conductivity of indium phosphide based superlattices (2003)

Semiconductor superlattice structures have shown promise as thermoelectric materials for their high power factor and low thermal conductivity. Heat conduction by phonons in semiconductor superlattices is controlled by two mechanisms: interface scattering by defects and/or roughness and phonon filtering by Bragg reflection. The thermal conductivity of three different InP/InGaAs superlattices was measured from 77-300 K using the 3/spl omega/ method. Small "dips" in the measured thermal conductivity were observed near 90 K, which may be indicative of phonon filtering.
Host Defense Mechanisms Against Infectious Bovine Rhinotracheitis Virus: In Vitro Stimulation of Sensitized Lymphocytes by Virus Antigen (1974)

Isolated peripheral blood lymphocytes (PBL) from cattle immunized or infected with infectious bovine rhinotracheitis (IBR) virus were cultured in vitro with ultraviolet light-inactivated IBR virus, and the degree of lymphocyte blastogenesis was quantitated by measurement of the uptake of [(3)H]thymidine into acid-insoluble material. Lymphocyte blastogenesis only occurred with PBL from immunized or infected animals. The optimal conditions for lymphocyte blastogenesis were defined. Blastogenesis was specific since cells from animals immunized against IBR failed to react with two other herpesvirus antigens tested, herpes simplex and equine rhinopneumonitis viruses. Blastogenesis could be prevented by reacting IBR antigen with IBR-specific antibody before adding to cultures, but incorporating IBR-specific antibody in the culture medium after adding free antigen failed to inhibit blastogenesis. With intranasally infected animals, lymphocyte blastogenesis was detectable after 5 days, reached peak levels between days 7 and 10, and then declined to low levels by day 19. In contrast, levels of neutralizing antibody were barely detectable on day 7 and reached maximal concentrations on day 19. The lymphocyte blastogenesis assay was emphasized as a convenient and useful in vitro correlate of cell-mediated immunity that should help define the role of cell-mediated immunity in immunity to herpesviruses.
High sensitive superconductor-semiconductor-superconductor THz detector (2010)

We describe a high sensitivity THz detector based on the hot electron effect in a highly doped thin silicon semiconducting layer with tunnelling contacts to superconducting islands (S-Sm-S).
FINFET technology featuring high mobility SiGe channel for 10nm and beyond (2016)

SiGe for channel material has been explored as a major technology element after the introduction of FINFET into CMOS technology [1–4]. Research on long channel FETs and discrete short channel FETs demonstrated benefits in mobility [1–4] and reliability [2]. Given the disruption that SiGe FIN brings, every aspect associated with SiGe FIN needs to be carefully studied towards technology insertion. In this paper, we report the latest SiGe-based FINFET CMOS technology development. CMOS FINFETs with Si-FIN nFET and SiGe-FIN pFET is demonstrated as a viable technology solution for both server and mobile applications at 10nm node and beyond.
Experimental Evaluation and Modeling Analysis of Micromilling of Hardened H13 Tool Steels (2011)

This study is focused on experimental evaluation and numerical modeling of micromilling of hardened H13 tool steels. Multiple tool wear tests are performed in a microside cutting condition with 100 μm diameter endmills. The machined surface integrity, part dimension control, size effect, and tool wear progression in micromachining of hardened tool steels are experimentally investigated. A strain gradient plasticity model is developed for micromachining of hardened H13 tool steel. Novel 2D finite element (FE) models are developed in software ABAQUS to simulate the continuous chip formation with varying chip thickness in complete micromilling cycles under two configurations: microslotting and microside cutting. The steady-state cutting temperature is investigated by a heat transfer analysis of multi micromilling cycles. The FE model with the material strain gradient plasticity is validated by comparing the model predictions of the specific cutting forces with the measured data. The FE model results are discussed in chip formation, stress, temperature, and velocity fields to great details. It is shown that the developed FE model is capable of modeling a continuous chip formation in a complete micromilling cycle, including the size effect. It is also shown that the built-up edge in micromachining can be predicted with the FE model.
Performance Testing of Shock Absorbers (1986)

Abstract For a better understanding and evaluation of shock absorber performance, detailed data upon their relevant physical parameters, such as spring characteristics and energy dissipation properties, have been measured in a test jig. Down hole tests where well defined sinusoidal vibrations are generated in a 1000 m vertical drill string by means of a down hole exciter were also performed. The drill string response above the shock absorber is measured by a hard wired MWD tool giving high frequency data on accelerations, WOB, torque and pressures. Examples of test results for different types of absorbers are presented and discussed for both laboratory and downhole tests.
Quantum Photonic Wavelength Conversion and Modulation using Low Loss Aluminum Nitride (2017)

An AlN photonic chip for quantum wavelength convention and modulation is designed and fabricated. The waveguide has low loss down to 1.2 dB/cm. Fast switching using Pockels effect and second harmonic generation is achieved.
Evaluation of the prognostic significance of Eosinophilia and Basophilia in a larger cohort of patients with myelodysplastic syndromes (2010)

The evaluation of eosinophils and basophils in patients with MDS was helpful and may complement the spectrum of variables to optimize prognostication in MDS.
Bradykinin Antagonism Following Oral Protease Therapy (1963)

Orally given proteolytic enzymes appear to antagonize 3 bradykinin physiologic responses: hypotension, smooth muscle contraction and enhanced capillary permeability. Whether these observations relate to anti-inflammatory activity of orally given proteolytic enzymes requires further study.
A Survey of Comics Research in Computer Science (2018)

Graphic novels such as comic books and mangas are well known all over the world. The digital transition started to change the way people are reading comics: more and more on smartphones and tablets, and less and less on paper. In recent years, a wide variety of research about comics has been proposed and might change the way comics are created, distributed and read in the future. Early work focuses on low level document image analysis. Comic books are complex; they contains text, drawings, balloons, panels, onomatopoeia, etc. Different fields of computer science covered research about user interaction and content generation such as multimedia, artificial intelligence, human–computer interaction, etc. with different sets of values. We review the previous research about comics in computer science to state what has been done and give some insights about the main outlooks.
Specific Targeting of the EBV Lytic Phase Protein BNLF2a to the Transporter Associated with Antigen Processing Results in Impairment of HLA Class I-Restricted Antigen Presentation (2009)

EBV persists for life in the human host while facing vigorous antiviral responses that are induced upon primary infection. This persistence supports the idea that herpesviruses have acquired dedicated functions to avoid immune elimination. The recently identified EBV gene product BNLF2a blocks TAP. As a result, reduced amounts of peptides are transported by TAP from the cytoplasm into the endoplasmic reticulum (ER) lumen for binding to newly synthesized HLA class I molecules. Thus, BNLF2a perturbs detection by cytotoxic T cells. The 60-aa-long BNLF2a protein prevents the binding of both peptides and ATP to TAP, yet further mechanistic insight is, to date, lacking. In this study, we report that EBV BNLF2a represents a membrane-associated protein that colocalizes with its target TAP in subcellular compartments, primarily the ER. In cells devoid of TAP, expression levels of BNLF2a protein are greatly diminished, while ER localization of the remaining BNLF2a is retained. For interactions of BNLF2a with the HLA class I peptide-loading complex, the presence of TAP2 is essential, whereas tapasin is dispensible. Importantly, we now show that in B cells supporting EBV lytic replication, the BNLF2a protein is expressed early in infection, colocalizing and associating with the peptide-loading complex. These results imply that, during productive EBV infection, BNLF2a contributes to TAP inhibition and surface HLA class I down-regulation. In this way, EBV BNLF2a-mediated evasion from HLA class I-restricted T cell immunity contributes to creating a window for undetected virus production.
Studies of changes in volume in right ventricle with electrical bio impedance (2002)

&lt;p&gt;In intracardiac impedance, electrical bio-impedance is measured inside the heart. This signal is known to reflect the volume of blood passing in and out of the ventricles. In transthoracic impedance the measurement current and voltage sensing is connected on the subject’s chest. In this thesis, the intracardiac impedance is studied in general, and in the filling phase (diastole) in particular.&lt;/p&gt;&lt;p&gt;The diastolic intracardiac impedance displays a consistent slope change (notch). The notch in the present thesis has similar features as the noninvasive transthoracic impedance O-wave reported earlier. The notch occurrence was found to be well comparable with results in work with O-wave. The notch was found closely after early rapid ventricular filling but before ventricular filling caused by atrial contraction and it is concluded that the notch is not caused by atrial contraction. The notch is most likely caused by cardiac wall movements in rapid ventricular filling.&lt;/p&gt;&lt;p&gt;The observations in this thesis are made in two different data sets; in animals and in humans and with different types of intracardiac leads. The lead implantations were performed by several different physicians. With the consistent results from these two studies at hand, this licentiate thesis concludes that the diastolic intracardiac impedance notch is a characteristic of intracardiac impedance, that the notch is the intracardiac equivalent of the non-invasive transthoracic impedance O-wave and that it is a sensed physiological cardiac parameter of diastole. Since the present data is measured intracardically it can be concluded that the non-invasive O-wave in fact is caused by cardiac movements.&lt;/p&gt;&lt;h3&gt;List of scientific papers&lt;/h3&gt;&lt;p&gt;I. Karin Järverud, Stig Ollmar, Lars-Åke Brodin. Analysis of the O-wave in acute right ventricular apex impedance measurements with a standard pacing lead in animals. Med Biol Eng Comput. 2002 Sep;40(5):512-9. &lt;br&gt;&lt;a href="https://doi.org/10.1007/BF02345448"&gt;https://doi.org/10.1007/BF02345448&lt;/a&gt;&lt;br&gt;&lt;br&gt; &lt;/p&gt;&lt;p&gt;II. Karin Järverud, Börje Darpö, Lars-Åke Brodin, Stig Ollmar. Descriptive analysis and initial finding of O-wave in acute right ventricular apex impedance measured with a standard pacing lead in human. [Submitted]&lt;/p&gt;
Comparative study of the ocular irritation potential of various alkyl polyglucoside surfactants (2009)

In the present work, we assessed the relationship between alkyl carbon chain length and ocular irritation potentials using the hen's egg test-chorioallantoic membrane (HET-CAM) and bovine corneal opacity and permeability (BCOP) assays using 5 commercial alkyl polyglucoside surfactants with different compositions of alkyl chain lengths (C(6)-C(16)). With HET-CAM, there was a good correlation between the proportion of C(10) alkyl polyglucoside and the eye irritation potential Q score (r(2) = 0.912, p = .011). There were no significant differences between the proportion of C(10) alkyl polyglucoside and corneal opacity in BCOP assays; however, there was a relatively high positive correlation between the proportion of C(10) alkyl carbon chain lengths and corneal permeability (r(2) = 0.736, p = .063).
Identification of newly-discovered sources belonging to the 4th IBIS\n catalog and to the 54 months Palermo Swift/BAT catalog (2013)

The most recent all-sky surveys performed with the INTEGRAL and SWIFT\nsatellites allowed the detection of more than 1500 sources in hard X-rays above\n20 keV. About one quarter of them has no obvious counterpart at other\nwavelengths and therefore could not be associated with any known class of\nhigh-energy emitting objects. Although cross-correlation with catalogues or\nsurveys at other wavelengths (especially soft X-rays) is of invaluable support\nin pinpointing the putative optical candidates, only accurate optical\nspectroscopy can reveal the true nature of these sources. With the aim of\nidentifying them, we started in 2004 an optical spectroscopy program which uses\ndata from several telescopes worldwide and which proved extremely successful,\nleading to the identification of about 200 INTEGRAL objects and nearly 130\nSwift sources. Here we want to present a summary of this identification work\nand an outlook of our preliminary results on identification of newly-discovered\nsources belonging to the 4th IBIS catalog and to the 54 months Palermo\nSwift/BAT catalog.\n
A Realistic Coordinated Scheduling Scheme for the Next-Generation RAN (2018)

The design of the 5G next-generation radio access network (NG-RAN) proposes the division of the next- generation eNodeB (gNB) into centralized and distributed units. Centralization should facilitate coordination of RAN functions between gNBs, but the actual benefits of it are still unclear. In this paper, we provide a study of the feasibility and benefits of coordinated downlink scheduling. We first analyze the time constraints that a coordinated scheduler has to face from a theoretical perspective, and we back them with an experimental proof-of-concept. Then, we present a lightweight scheme for coordinated link adaptation that matches the previous constraints. We show that coordination is indeed feasible with state- of-the-art technology, although very limited by time constraints. Finally, we show the results of our experimental testbed, which successfully implemented the described coordination scheme under the predicted constraints.
Vector Brillouin optical time-domain analysis with Raman amplification and optical pulse coding (2019)

This paper proposes a new vector Brillouin optical time-domain analysis optical fiber sensor with large dynamic range and high signal-to-noise ratio that combines distributed Raman amplification with optical pulse coding. The optimized Raman pumping configurations are numerically simulated by solving the coupled differential equations of the hybrid Brillouin-Raman process, and experimentally investigated with respect to the Brillouin pump pulse. A vector network analyzer is adopted to extract both the amplitude and phase spectrograms of the Brillouin interaction in a distributed fashion which effectively lessens the impact of the Raman relative intensity noise transfer problem and achieve high accuracy measurement over a long sensing distance. Advanced pulse coding is further introduced to increase the sensing range under high spatial resolution. Initial experimental results of phase and amplitude from a custom built BOTDA system is presented. Compared to typically tens of kilometers measurement distance of conventional Brillouin optical time-domain analysis techniques, the proposed optical fiber Brillouin sensor has the potential to greatly enhances sensing range up to one hundred kilometers or greater, providing distributed temperature and strain monitoring of high spatial resolution and high sensing resolution in structures such as oil and natural gas pipelines.
[Nphe1]‐Nociceptin (1‐13)‐NH2, a nociceptin receptor antagonist, reverses nociceptin‐induced spatial memory impairments in the Morris water maze task in rats (2000)

1. The present study was undertaken to investigate the effects of the novel nociceptin receptor antagonist, [Nphe(1)]-Nociceptin (1-13)-NH(2) (bilateral intrahippocampal injection, 50 nmole rat(-1)) on purported nociceptin-induced (bilateral intrahippocampal injection, 5 nmole rat(-1)) deficits in spatial learning in the rat Morris water maze task. In addition, experiments were performed in an 'open field' to investigate possible peptide-induced changes in exploratory behaviour. 2. Nociceptin significantly impaired the ability of the animal to locate the hidden platform throughout training (P<0.001 versus control group). 3. Pretreatment with [Nphe(1)]-Nociceptin (1-13)-NH(2) significantly blocked nociceptin-induced impairment of spatial learning (P<0.001 versus nociceptin group). 4. A probe trial revealed that vehicle-treated animals spent more time in the quadrant that had previously contained the hidden platform, whereas nociceptin-treated animals did not spend more time in any one quadrant. 5. Learning impairments were not attributable to non-specific deficits in motor performance or change in exploratory behaviour. 6. Taken together, our results reveal that [Nphe(1)]-Nociceptin (1-13)-NH(2) represents an effective and useful in vivo antagonist at the nociceptin receptors involved in learning and memory.
Optimization of signal behavior in the transition to driven equilibrium in steady‐state free precession sequences (2002)

A new technique to avoid the initial signal fluctuations in steady-state free precession (SSFP)-sequences, such as trueFISP, FIESTA, and refocused FFE, is presented. The "transition into driven equilibrium" (TIDE) sequence uses modified flip angles over the initialization phase of a SSFP experiment, which not only avoids image artifacts but also improves the signal-to-noise ratio (SNR) and contrast behavior compared to conventional approaches. TIDE is demonstrated to be robust against variations of T(1) and T(2), and leads to a monotonous signal evolution for off-resonance spins. The basic principles can also be applied repetitively to optimize continuous 3D acquisitions.
Real-Time Ozone Detection Based on a Microfabricated Quartz Crystal Tuning Fork Sensor (2009)

A chemical sensor for ozone based on an array of microfabricated tuning forks is described. The tuning forks are highly sensitive and stable, with low power consumption and cost. The selective detection is based on the specific reaction of the polymer with ozone. With a mass detection limit of ∼2 pg/mm(2) and response time of 1 second, the sensor coated with a polymer sensing material can detect ppb-level ozone in air. The sensor is integrated into a miniaturized wearable device containing a detection circuit, filtration, battery and wireless communication chip, which is ideal for personal and microenvironmental chemical exposure monitoring.
Non-neuronal cell outgrowth inC. elegans (2017)

Cell outgrowth is a hallmark of some non-migratory developing cells during morphogenesis. Understanding the mechanisms that control cell outgrowth not only increases our knowledge of tissue and organ development, but can also shed light on disease pathologies that exhibit outgrowth-like behavior. <i>C. elegans</i> is a highly useful model for the analysis of genes and the function of their respective proteins. In addition, <i>C. elegans</i> also has several cells and tissues that undergo outgrowth during development. Here we discuss the outgrowth mechanisms of nine different <i>C. elegans</i> cells and tissues. We specifically focus on how these cells and tissues grow outward and the interactions they make with their environment. Through our own identification, and a meta-analysis, we also identify gene families involved in multiple cell outgrowth processes, which defined potential <i>C. elegans</i> core components of cell outgrowth, as well as identify a potential stepwise cell behavioral cascade used by cells undergoing outgrowth.
Analyzing standard RF Waveform Designs for WPT (2021)

The possibility to harvest energy from ambient radio-frequency (RF) sources has intrigued humankind since past several decades. In this context, there has been a tremendously growing research interest in the field of wireless power transfer (WPT) using the RF regime of the electromagnetic (EM) spectrum. In this paper, we investigate the aspect of real-time energy harvesting (EH) via different types of waveform designs such as Orthogonal Frequency Division Multiplexing (OFDM), Square, Triangular, Sinusoidal, and Sawtooth. We make use of a Software Defined Radio (SDR) and a Powercast P21XXCSREVB EH module to carry out the experiments on practical device performance. Specifically, we are interested in obtaining some insights based on the comparison between the aforementioned waveform designs from the perspectives of separation distance between the USRP and P21XXCSR-EVB EH module, and power emission via USRP. Correspondingly, the demonstration of the EH is provided in terms of the above-mentioned investigation metrics, while seeking the best waveform to support WPT.
Comparative oncology: The paradigmatic example of canine and human mast cell neoplasms (2018)

In humans, advanced mast cell (MC) neoplasms are rare malignancies with a poor prognosis. Only a few preclinical models are available, and current treatment options are limited. In dogs, MC neoplasms are the most frequent malignant skin tumours. Unlike low-grade MC neoplasms, high-grade MC disorders usually have a poor prognosis with short survival. In both species, neoplastic MCs display activating KIT mutations, which are considered to contribute to disease evolution. Therefore, tyrosine kinase inhibitors against KIT have been developed. Unfortunately, clinical responses are unpredictable and often transient, which remains a clinical challenge in both species. Therefore, current efforts focus on the development of new improved treatment strategies. The field of comparative oncology may assist in these efforts and accelerate human and canine research regarding diagnosis, prognostication, and novel therapies. In this article, we review the current status of comparative oncology approaches and perspectives in the field of MC neoplasms.