gebhart/patrepeval huggingface dataset:
Oxidation of Primary Aminesto Ketones (2008)

A simple method for the oxidation of primary amines to the corresponding ketones that proceeds in the presence of both moisture and air is described. Treatment of an amine with benzoyl peroxide in the presence of caesium carbonate, followed by warming of the hydroxylamine product to 50-70 C leads directly to the ketone. The method is shown to be effective for both benzylic and aliphatic substrates.
Secretory component in human mammary carcinoma. (1975)

Since secretory component is thought to be a normal glandular epithelial cell product, surgical specimens from patients with mammary carcinoma, an epithelial cancer, were studied with antisera to human free secretory component by indirect immunofluorescence microscopy. Normal breast tissue (10 cases) showed fluorescent epithelial cells confined to normal ducts. This was in marked contrast to ubvasive mammary carcinoma (20 cases), which showed intense staining of tumor cells and stromal cells in addition to the normal ductular epithelium. Metastases in axillary lymph nodes (2 cases) showed intense fluorescence for secretory component, whereas axillary nodes without metastases from 2 patients with breast cancer showed no fluorescence. In both normal and tumor tissue, antiimmunoglobulin A stained only ducts and subepithelial plasma cells, thus establishing that the secretory component in tumor cells was not part of an intact secretory immunoglobulin A molecule. This finding was not restricted to mammary carcinoma, since preliminary studies of colon, lung, and bladder carcinoma also demonstrated tumor cells with cytoplasmic fluorescence for secretory component. In contrast, the tumor cells in 2 cases of sarcoma, a nonepithelial cancer, did not exhibit fluorescence for secretory component.
Role of the Direct Interaction between Factor VIII C2 and Factor IXa Gla Domain in the Factor Xase Complex. (2007)

Abstract Factor VIII functions as a cofactor for factor IXa in the anionic phospholipid surface-dependent conversion of factor X to Xa. It is well-known that the A2 and A3 domains of factor VIII interact with the catalytic domain and EGF2 domain of factor IXa, respectively. Recently, Furie et al. have reported that the Gla domain of factor IXa (factor IXa-GD) interacts with the light chain of factor VIII. However, the factor IXa-GD-interactive site on the light chain remained to be investigated. In the current study, the recombinant C2 (rC2) domain of factor VIII was prepared using a yeast secretion system. ELISA-based assay in the absence of phospholipid showed the Glu-Gly-Arg-active site modified factor IXa (EGR-factor IXa) bound to the immobilized rC2 domain dose-dependently, and the binding ability was maximum under the condition of 150 mM NaCl/1 mM CaCl2. This binding was competitively inhibited by the addition of excess of factor VIII or rC2 domain, supporting the specificity of this interaction. Furthermore, the presence of high ionic strength and the metal-ion chelator EDTA blocked this binding by ∼95 and ∼75%, respectively. Surface plasmon resonance-based assay showed that the binding affinity (Kd) of rC2 domain for EGR-factor IXa was 108 ± 15.5 nM. GD less-factor IXa, deleting the GD completely, failed to bind to rC2 domain. A monoclonal antibody against factor IXa-GD specific for calcium-dependent conformation (mAbIXa-GD) also inhibited (∼ 95%) the rC2 domain binding to EGR-factor IXa in a dose-dependent manner (IC50; 758 nM), suggesting the authentic of the C2 domain and factor IXa-GD interaction. The addition of rC2 domain or mAbIXa-GD inhibited the factor IXa-catalyzed factor X activation with factor VIIIa in the absence of phospholipid (IC50; 15.7 μM or 43.2 nM, respectively), whilst both any little affected in the absence of factor VIIIa. In addition, the ∼8-kDa C2 fragment obtained by V8 protease digestion (residues 2182–2259) bound directly to EGR-factor IXa. Taken together, these results indicate that factor VIII C2 domain directly interacts with factor IXa-GD via both the electrostatic- and calcium-dependent interactions. Furthermore, our results provide the first evidence for an essential role of the C2 domain in the association between factor VIII and factor IXa in the factor Xase complex.
System-level analysis of IEEE 802.11ah technology for unsaturated MTC traffic (2018)

Enabling the Internet of Things, machine-type communications (MTC) is a next big thing in wireless innovation. In this work, we concentrate on the attractive benefits offered by the emerging IEEE 802.11ah technology to support a large number of MTC devices with extended communication ranges. We begin with a comprehensive overview of the novel features introduced by the latest IEEE 802.11ah specifications followed by the development of a powerful mathematical framework capturing the essential properties of a massive MTC deployment with unsaturated traffic patterns. Further, we compare our analytical findings for a characteristic MTC scenario against respective system-level simulations across a number of important performance indicators. Our analytical results provide adequate performance predictions even when simulations are challenged by the excessive computational complexity. In addition, we study the novel IEEE 802.11ah mechanisms offering improved support for massive device populations and conclude on their expected performance.
Task Assignment in a Virtualized GPU Enabled Cloud (2018)

Cloud computing vendors are beginning to offer GPU based high performance computing as a service. One approach uses virtual machines (VM), running in a hypervisor like VMware vSphere, equipped with virtual GPUs like Nvidia's vGPU solution. In this approach, multiple VMs running concurrently can share a single GPU. The number of VMs that share the GPU can be configured by the user/system administrator. Further, VMs can be re-assigned to GPUs, if more than one is available, dynamically. This approach allows tasks/jobs that use GPUs to run in individual VMs guaranteeing isolation whilst sharing resources. In a typical cloud environment with multiple servers each with one or more GPUs, finding an efficient, fast solution to the problem of placing VMs (i.e. VM-placement) on GPUs and moving them around as needed is extremely important to achieve high throughput of tasks while maximizing server utilization and minimizing task wait times. In this paper, we present the simulator we built to compare different solutions to the problem of VM-placement together with some early results.
Multiple Sclerosis Impact Scale (MSIS-29): relation to established measures of impairment and disability (2004)

Our study supports the use of the MSIS-29 as a measure for the assessment of physical impact of MS on normal daily life. In addition, our data provides a deeper understanding of the factors that determine both physical and psychological disease impact. Discrepancies between the latter two aspects deserve further attention.
Search for high mass dilepton resonances in pp collisions at √s = 7 TeV with the ATLAS experiment (2011)

Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, el nombre del grupo de colaboración, si le hubiere, y los autores pertenecientes a la UAM
Eddy Current Loss Analysis of Underwater Wireless Power Transfer System (2018)

Underwater Wireless Power Transfer (WPT) has attracted much attention in recent years. In an underwater WPT system, the eddy current loss tends to be non-negligible as the frequency and current increase. Thus, it is crucial to analyze the eddy current loss in an underwater WPT system. The analytical model of the eddy current loss of a coreless WPT system in seawater is established with Maxwell's equations. The expressions of the electric field intensity and the eddy current loss are derived and the eddy current loss is analyzed in different circumstances. An underwater WPT prototype is set up and the experimental results verify the theoretical analysis.
Emilin-1 controls arterial blood pressure by regulating contractility of vascular smooth muscle cells (2011)

Emilin-1 is a protein of the elastic extracellular matrix (ECM) expressed in interstitial connective tissue and in the cardiovascular system. <em>Emilin1 </em>null mice display hypotrophic remodeling of the wall of conductance arteries and increased blood pressure. The protein regulates the bioavailability of TGF-b by inhibiting proteolysis of the proTGF-b precursor to LAP/TGF-b, a complex from which the growth factor can be subsequently released for receptor binding. In the absence of Emilin-1, the amount of active TGF-b is increased. As Emilin-1 is expressed in blood vessels starting from early stages of embryonic development to adulthood, a key question concerning the function of the protein is whether the <em>Emilin1<sup>-/-</sup> </em>phenotype is the result of a developmental defect or the function of the protein is required for the regulation of blood pressure and arterial structure also in the adult. The conditional gene targeting procedure chosen to inactivate the <em>Emilin1</em> gene in smooth muscle cells (SMCs) of adult mice included the use of floxed <em>Emilin1</em> and CreER<sup>T2</sup> (a tamoxifen inducible <em>Cre</em> recombinase) under the control of the smooth muscle myosin heavy chain (<em>Smmhc</em>) promoter. Tamoxifen administration induced activity of Cre specifically in vascular and visceral SMCs, as revealed by X-gal staining of tissues from animals with the Rosa26R mutation. When <em>Emilin1<sup>flox/flox</sup></em><sup> </sup>mice carrying the <em>Smmhc</em>-CreER<sup>T2</sup> transgene were given tamoxifen for 7 days, Emilin-1 disappeared completely in 10-12 days from start of treatment. In the same time, blood pressure increased of about 20 mmHg, a level that was stably maintained thereafter. The myogenic response of second branch meseteric arteries, evaluated using a pressure myograph, was found to be increased in <em>Emilin1<sup>-/-</sup></em> mice. Additional experiments with aorta and mesenteric artery SMC cultures from control and mutant mice showed that lack of Emilin-1 enhanced phosphorylation of myosin light chain 20 when cells were stimulated with the a1-adrenergic receptor agonists phenylephrine or with angiotensin II. Moreover, basal cytosolic Ca<sup>2+</sup> levels and calcium transients induced by stimulation with phenylephrine and angiotensin II were increased in SMCs from <em>Emilin1<sup>-/-</sup></em> mutants. The data suggest that Emilin-1 expression is continuously required for regulation of blood pressure and that the increase of TGF-b activity induced by diminished Emilin-1 stimulates, likely through alteration of intracellular calcium homeostasis, contractility of vascular SMC to mechanical and chemical stimuli with ensuing hypertension.<br>
Controlling the melting transition of semi-crystalline self-assembled block copolymer aggregates: controlling release rates of ibuprofen (2017)

Thermoresponsive bicontinuous and multi-lamellar micelles were self-assembled from poly[ethylene oxide]-<italic>block</italic>-(poly[octadecyl methacrylate]-<italic>random</italic>-poly[docosyl methacrylate]).
Differential effects of the circadian system and circadian misalignment on insulin sensitivity and insulin secretion in humans (2018)

Glucose tolerance is lower at night and higher in the morning. Shift workers, who often eat at night and experience circadian misalignment (i.e. misalignment between the central circadian pacemaker and the environmental/behavioural cycles), have an increased risk of type 2 diabetes. To determine the separate and relative impacts of the circadian system, behavioural/environmental cycles, and their interaction (i.e. circadian misalignment) on insulin sensitivity and β-cell function, the oral minimal model was used to quantitatively assess the major determinants of glucose control in 14 healthy adults using a randomized, cross-over design with two 8-day laboratory protocols. Both protocols involved 3 baseline inpatient days with habitual sleep/wake cycles, followed by 4 inpatient days with the same nocturnal bedtime (circadian alignment) or with 12-hour inverted behavioural/environmental cycles (circadian misalignment). The data showed that circadian phase and circadian misalignment affect glucose tolerance through different mechanisms. While the circadian system reduces glucose tolerance in the biological evening compared to the biological morning mainly by decreasing both dynamic and static β-cell responsivity, circadian misalignment reduced glucose tolerance mainly by lowering insulin sensitivity, not by affecting β-cell function.
S&T-56 PROSTATE CANCER-ASSOCIATED ABERRANT GLYCOSYLATED S2,3PSA TEST UTILIZING MICROCAPILLARY ELECTROPHORESIS-BASED IMMUNOASSAY ENABLED CLINICAL APPLICATION FOR EARLY DIAGNOSIS OF PROSTATE CANCER (2016)

images. Moreover, the modified Glasgow prognostic score (mGPS), was measured based on C-reactive protein (CRP) and albumin levels (score: 2, CRP>1.0 mg/dL and albumin<3.5 gd/L; score 1, CRP>1.0 mg/dL; score 0, CRP1.0 mg/dL). Progression-free survival (PFS) and overall survival (OS) were analyzed using the Kaplan-Meier method and Cox proportional hazard models.
Diversity of respiratory parameters and metabolic adaptation to low oxygen tension in mesenchymal stromal cells (2022)

In contrast to adult MSCs, fetal MSCs displayed similar respiration and aerobic glycolysis at different O<sub>2</sub> culture concentrations during expansion. Adult MSCs adjusted their respiration to glycolytic activities, depending on the culture conditions thus displaying a more mature metabolic function. These findings are relevant for establishing optimal <i>in vitro</i> culturing conditions, with the aim to maximize engraftment and therapeutic outcome.
High Power High Frequency Soft Switching Converter Using Serial Connected Switches (1999)

In the field of high voltage power conversion, low or medium voltage inverters are generally used with high voltage transformers [1]. This article presents a high voltage chopper supplied directly by a high voltage source. At the same power level, higher input voltage means lower current stress in the switches, making realisation on printed board easier. Such a solution requires serial connection to realise the high voltage switch. To reach a switching frequency of several tens of kHz, MOS or IGBT are used. Serial connection of power components encounters two major problems in hard switching: voltage unbalance and overcurrents due to parasitic capacitances to ground during turn on. As the number of stages connected in series increases, those problems become more crucial.Voltage unbalance is mainly due to differential delay time of drive circuit (switching on and off phases) and speed scattering (switching off phases). Synchronous orders and equal switching speeds are necessary to obtain a good voltage sharing [2]. Otherwise, active clamping can be used for grid components like IGBTS [3]. During the off state, scattering of leakage current between semiconductors gives rise to significant voltage unbalance. Sharing resistor can be added in parallel of each switch for current balancing. At high frequency, they are no more needed [4]. Parasitic overcurrents in hard commutation, for high voltage low current switches using serial connection, are one of the main problems [5]. Soft switching can be used to reduce switching losses, voltage unbalance and parasitic overcurrents. This article presents a converter combining serial connection with soft switching.
Appoptosin interacts with mitochondrial outer-membrane fusion proteins and regulates mitochondrial morphology (2016)

Mitochondrial morphology is regulated by fusion and fission machinery. Impaired mitochondria dynamics cause various diseases, including Alzheimer's disease. Appoptosin (encoded by SLC25A38) is a mitochondrial carrier protein that is located in the mitochondrial inner membrane. Appoptosin overexpression causes overproduction of reactive oxygen species (ROS) and caspase-dependent apoptosis, whereas appoptosin downregulation abolishes β-amyloid-induced mitochondrial fragmentation and neuronal death during Alzheimer's disease. Herein, we found that overexpression of appoptosin resulted in mitochondrial fragmentation in a manner independent of its carrier function, ROS production or caspase activation. Although appoptosin did not affect levels of mitochondrial outer-membrane fusion (MFN1 and MFN2), inner-membrane fusion (OPA1) and fission [DRP1 (also known as DNM1L) and FIS1] proteins, appoptosin interacted with MFN1 and MFN2, as well as with the mitochondrial ubiquitin ligase MITOL (also known as MARCH5) but not OPA1, FIS1 or DRP1. Appoptosin overexpression impaired the interaction between MFN1 and MFN2, and mitochondrial fusion. By contrast, co-expression of MFN1, MITOL and a dominant-negative form of DRP1, DRP1(K38A), partially rescued appoptosin-induced mitochondrial fragmentation and apoptosis, whereas co-expression of FIS1 aggravated appoptosin-induced apoptosis. Together, our results demonstrate that appoptosin can interact with mitochondrial outer-membrane fusion proteins and regulates mitochondrial morphology.
Synthesis of Highly Substituted Pyridazines Through Alkynyl Boronic Ester Cycloaddition Reactions. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Low-power lock-in amplifier for complex impedance measurement (2009)

This paper presents a fully integrated lock-in amplifier intended for nanowire gas sensing. The nanowire will change its conductivity according to the concentration of an absorbing gas. To ensure accurate nanowire impedance measurement, the lock-in technique is implemented to attenuate the low frequency noise and offset by synchronous demodulation or phase-sensitive detection (PSD). Dual-channel lock-in amplifier also provides both resistive and capacitive information of the nanowire in separate channels. Measurement results of the resistors and capacitors show 2% resolution over 10 KΩ – 40 KΩ resistance and 3% resolution over 0.5 nF–1.8 nF capacitance. Moreover, a palladium nanowire sensor was placed in a sealed chamber filled with 10% hydrogen in nitrogen, a 28.7 KΩ to 32.1 KΩ impedance variation was measured through the lock-in amplifier by slowly decreasing the hydrogen concentration. The chip has been implemented with UMC 0.18µm CMOS technology and occupies an area of 2 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . The power consumption of the readout circuit is 2 mW from a 1.8V supply.
A model for dual polarized HF MIMO communications (2015)

The ionosphere has two modes of propagation, each with a different polarization. Theory and measurements show that the paths associated with these two polarization modes have independent fades. Transmitting and receiving on two co-located orthogonal linear polarized antennas 1) makes the link more robust to fading, 2) removes possibility of polarization loss, 3) can nearly double the data throughput by effectively establishing two links, and 4) is a form of multiple input multiple output communications (MIMO). This paper introduces a simple and flexible model for a dual polarized (DP) HF MIMO channel, illustrates how to develop specific instantiations of the model based on channel measurements, including ionosondes, and presents some performance comparisons between single input single output HF communications and DP HF MIMO. A contribution of this paper is the introduction of this flexible DP HF MIMO channel model that will allow researchers to develop instantiations of HF DP channel models from readily available ionosonde data and determine the performance benefits of HF DP MIMO under a variety of ionospheric propagation conditions and antenna orientations.
NPM-ALK Converts JUNB from a Tumor Suppressor to an Oncogene. (2006)

Abstract High expression of the tumor necrosis factor receptor CD30 and the AP-1 transcription factor JunB are the hallmark of anaplastic large cell lymphoma (ALCL). In contrast to the prototypic AP-1 factor c-Jun, JunB exerts an antioncogenic function in most cell types. Its functional role in ALCL remains uncertain. In about 50% of nodal ALCL the balanced chromosomal rearrangement t(2;5)(p23;q35), generating the fusion protein nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), can be detected. Expression of this fusion kinase induces malignancy in mice and also leads to IL-3 independent outgrowth of the murine hematopoietic cell line Ba/F3. Using NPM-ALK transduced Ba/F3 cells, we show that NPM-ALK induces JunB expression and activation as verified by quantitative RT-PCR, immunoblot and electro-mobility supershift assay. Interestingly, NPM-ALK transduced Ba/F3 cells also express CD30, which is undetectable in the corresponding wild type cells. Since NPM-ALK induces JunB and CD30 and also leads to growth factor independent proliferation in Ba/F3 cells, these cells mimic conditions present in ALCL. Knock down of JUNB in NPM-ALK expressing cells using RNA interference leads to downregulation of CD30. Moreover, this partial loss of JunB induces upregulation of p16INK4a and downregulation of CCND1, which directly affect the cell cycle at the G1/S transition. These observations indicate that JunB is an essential factor for CD30 regulation and for neoplastic transformation. To test if JunB by itself is sufficient to induce CD30 expression and IL-3 independence, we stably transduced Ba/F3 cells with JUNB. In Ba/F3 wild type (WT) cells, JunB expression leads to reverse effects compared to that observed in NPM-ALK transduced Ba/F3. Ba/F3 WT cells do not become IL-3 independent. In addition, compared to vector control, JUNB-transduced Ba/F3 cells show a decrease in proliferation. Furthermore, an induction of p16INK4a and a decrease of CCND1 expression are observed. Moreover, aberrant JunB expression does not trigger CD30 expression in this system. Taken together, we show that both NPM-ALK and JunB are essential to induce CD30 expression. Furthermore the opposing effects of JunB on p16INK4a and CCND1 in the presence or absence of NPM-ALK indicate that NPM-ALK converts JUNB from a tumor suppressor to an oncogene.
Some applications of verifiable computation to biometric verification (2015)

Spurred by the advent of cloud computing, the domain of verifiable computations has known significant progress in recent years. Verifiable computation techniques enable a client to safely outsource its computations to a remote server. This server performs the calculations and generates a proof asserting their correctness. The client thereafter simply checks the proof to convince itself of the correctness of the output. In this paper, we study how recent advances in cryptographic techniques in this very domain can be applied to biometric verification.
Freeze-Dried Nonirradiated Experience (1993)

The history of fascia lata allograft use in general and in anterior cruciate ligament (ACL) reconstruction is presented. A review of mechanical data reveals that a 10-cm wide freeze-dried fascia lata graft will supply 231% the strength of an intact ACL. We present a technique for using a rolled fascia lata graft endoscopically for ACL reconstruction. The technique draws strength from lateral fluoroscopic imaging during tunnel preparation and graft placement. Clinical results in 100 patients followed an average of 3.4 years show the grafts intact in 98 patients with no laxity on KT-1000 testing compared to the other knee in 74 patients, and 1–5 mm increased laxity in 24 patients. There were two ruptured grafts. Ninety-three percent of the patients stated that they were functioning at their desired level of activity. We conclude that the described technique of ACL reconstruction with freeze-dried fascia lata allograft consistently gives an excellent clinical result.
Multibounce time-of-flight imaging for object reconstruction from indirect light (2012)

We demonstrate reconstruction methods that allow imaging ‘around a corner’ using time-of-flight data. We show an algorithm to reconstruct hidden objects from scattered light and ways to estimate the volume of hidden cavities.