gebhart/patrepeval huggingface dataset:
Network management research in ATDNet (1996)

The Advanced Technology Demonstration Network (ATDNet) is a major testbed facility established by DARPA and other U.S. government agencies to conduct network and applications research on the next generation of high speed ATM/SONET networks. This article presents the approaches and results of our work in network management on ATDNet. The research addresses different aspects of next-generation systems design, including integrated network management of different technology layers, multitier and multiprotocol architectures, robust distributed computing platforms, and object-oriented technologies. To address these challenges in a practical manner, the authors describe their implementation of a prototype software system developed on a distributed computing platform, discuss how this research addresses the current and evolving needs of ATDNet, and present possible future research directions.
Cholestane‐Based Liquid Crystals Containing a Difluorooxymethylene Bridge. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Engineering Design Tools for Shape Memory Alloy Actuators: CASMART Collaborative Best Practices and Case Studies (2016)

The primary goal of the Consortium for the Advancement of Shape Memory Alloy Research and Technology (CASMART) is to enable the design of revolutionary applications based on shape memory alloy (SMA) technology. In order to help realize this goal and reduce the development time and required experience for the fabrication of SMA actuation systems, several modeling tools have been developed for common actuator types and are discussed herein along with case studies, which highlight the capabilities and limitations of these tools. Due to their ability to sustain high stresses and recover large deformations, SMAs have many potential applications as reliable, lightweight, solid-state actuators. Their advantage over classical actuators can also be further improved when the actuator geometry is modified to fit the specific application. In this paper, three common actuator designs are studied: wires, which are lightweight, low-profile, and easily implemented; springs, which offer actuation strokes upwards of 200% at reduced mechanical loads; and torque tubes, which can provide large actuation forces in small volumes and develop a repeatable zero-load actuation response (known as the two-way shape memory effect). The modeling frameworks, which have been implemented in the design tools, are developed for each of these frequently used SMA actuator types. In order to demonstrate the versatility and flexibility of the presented design tools, as well as validate their modeling framework, several design challenges were completed. These case studies include the design and development of an active hinge for the deployment of a solar array or foldable space structure, an adaptive solar array deployment and positioning system, a passive air temperature controller for the regulation of flow temperatures inside of a jet engine, and a redesign of the Corvette active hatch, which allows for pressure equalization of the car interior. For each of the presented case studies, a prototype or proof-of-concept was fabricated and the experimental results and lessons learned are discussed. This analysis presents a collection of CASMART collaborative best practices in order to allow readers to utilize the available design tools and understand their modeling principles. These design tools, which are based on engineering models, can provide first-order optimal designs and are a basic and efficient method for either demonstrating design feasibility or refining design parameters. Although the design and integration of an SMA-based actuation system always requires application- and environment-specific engineering considerations, common modeling tools can significantly reduce the investment required for actuation system development and provide valuable engineering insight.
Re: Vitamin D3 Prevents Calcium-Induced Progression of Early-Stage Prostate Tumors by Counteracting TRPC6 and Calcium Sensing Receptor Upregulation (2018)

No AccessJournal of UrologyUrological Survey1 May 2018Re: Vitamin D3 Prevents Calcium-Induced Progression of Early-Stage Prostate Tumors by Counteracting TRPC6 and Calcium Sensing Receptor Upregulation Anthony AtalaMD Anthony AtalaAnthony Atala More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.014AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Re: Vitamin D3 Prevents Calcium-Induced Progression of Early-Stage Prostate Tumors by Counteracting TRPC6 and Calcium Sensing Receptor Upregulation." The Journal of Urology, 199(5), pp. 1115–1116 © 2018 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 199Issue 5May 2018Page: 1115-1116 Advertisement Copyright & Permissions© 2018 by American Urological Association Education and Research, Inc.MetricsAuthor Information Anthony Atala More articles by this author Expand All Advertisement PDF downloadLoading ...
What Have We Learnt from Experimental Renal Transplantation? (2010)

The first series of kidney transplantation performed in the experimental setting over a century ago and its subsequent translation into humans has initiated a whole new facet of medical practice that has benefited a large number of patients with end-stage kidney and other organ failure. It has proven to be an indispensable tool in our quest to advance our skills and knowledge and continues to play a role in the development of better treatment protocols. Here, we discuss the advantages and drawbacks of this technique and use key examples to illustrate how it has been exploited to achieve our goals.
Electromagnetically-Induced Transparency in a high aspect ratio magneto-optical trap (2006)

We have detected electromagnetically-induced transparency (EIT) in a cigar-shaped MOT. The asymmetric shape of probe absorption as a function of frequency is consistent with enhancement of optical depth due to wave guiding of the probe.
Nanostructured TiO2 and Its Application in Lithium‐Ion Storage (2011)

Abstract Titania nanorods and nanowires are synthesized via a hydrothermal reaction of amorphous TiO 2 in alkaline NaOH, followed by ion exchange in HCl aqueous solution, and dehydration at 400 °C. Although the hydrothermal treatment produces three different particle morphologies depending on the reaction time (nanosheets, nanorods, and nanowires), the products exhibit the same crystal structure. Ion exchange of Na 2 Ti 3 O 7 in HCl aqueous solution brings about a phase change to H 2 Ti 3 O 7 , but there is no change in the particle morphology. Dehydration of the nanostructured H 2 Ti 3 O 7 leads to two types of crystal structure—anatase TiO 2 for the nanorods, and TiO 2 –B for the nanowires—although no significant difference is found in the morphology of the products even after dehydration. The nanorods are 40–50 nm in length and 10 nm in diameter, whereas the nanowires are several micrometers in length and tens to hundreds of nanometers in thickness. In‐situ X‐ray diffraction revealed the formation of anatase TiO 2 from the TiO 2 –B above 450 °C. This finding implies that the phase transformation occurs rather slowly for the TiO 2 –B nanowires due to the larger particle size and higher crystallinity of H 2 Ti 3 O 7 . Tests with Li‐metal half cells indicated that the anatase TiO 2 nanorods are more favorable for the storage and release of Li ions because of their greater surface area than the TiO 2 –B nanowires.
Le stockage stationnaire d'énergie électrique : pourquoi et comment ? (2007)

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Analyzing the intelligibility of real-time mobile sign language video transmitted below recommended standards (2014)

Mobile sign language video communication has the potential to be more accessible and affordable if the current recommended video transmission standard of 25 frames per second at 100 kilobits per second (kbps) as prescribed in the International Telecommunication Standardization Sector (ITU-T) Q.26/16 were relaxed. To investigate sign language video intelligibility at lower settings, we conducted a laboratory study, where fluent ASL signers in pairs held real-time free-form conversations over an experimental smartphone app transmitting real-time video at 5 fps/25 kbps, 10 fps/50 kbps, 15 fps/75 kbps, and 30 fps/150 kbps, settings well below the ITU-T standard that save both bandwidth and battery life. The aim of the laboratory study was to investigate how fluent ASL signers adapt to the lower video transmission rates, and to identify a lower threshold at which intelligible real-time conversations could be held. We gathered both subjective and objective measures from participants and calculated battery life drain. As expected, reducing the frame rate/bit rate monotonically extended the battery life. We discovered all participants were successful in holding intelligible conversations across all frame rates/bit rates. Participants did perceive the lower quality of video transmitted at 5 fps/25 kbps and felt that they were signing more slowly to compensate; however, participants' rate of fingerspelling did not actually decrease. This and other findings support our recommendation that intelligible mobile sign language conversations can occur at frame rates as low as 10 fps/50 kbps while optimizing resource consumption, video intelligibility, and user preferences.
CO2 sensing with a 2005 nm thulium holmium co-doped fiber laser (2012)

We demonstrate an all-fiber thulium holmium co-doped fiber laser emitting at 2005 nm. By modulating the temperature of its fiber Bragg grating mirrors, we performed wavelength modulation spectroscopy and quantified CO2 concentration down to 2%.
30 kHz THz Pulse Detection based on Electro-Optical Sampling (2020)

The evolution of pump and probe technologies, especially terahertz time domain spectroscopy has led to a multitude of applications as well as an significant improvement in the available devices regarding dynamic range, bandwidth and measurement speed. Using a spectrometer based on electro-optical modulator ECOPS sampling, we present time domain spectroscopy pulses recorded at measurement rates of up to 60 kHz - faster than any result reported so far to our knowledge.
ARTHROSCOPIC REVISION OF FAILED OPEN ANTERIOR STABILIZATION OF THE SHOULDER (2009)

The purpose of this study is to report the results of arthroscopic Bankart repair following failed open treatment of anterior instability. We performed a retrospective review of twenty-two patients with recurrent anterior shoulder instability (i.e. subluxations or dislocations, with or without pain) after open surgical stabilization. There were seventeen men and five women with an average age of thirty-one years (range, 15–65). The most recent interventions consisted of sixteen osseous transfers (twelve Latarjet and four Eden-Hybinette), three open Bankart repairs and three capsular shifts. The causes of failure were additional trauma in twelve patients and complications related to the bone-block in thirteen (poor position, fracture, pseudarthrosis or lysis). All patients were noted to have distension of the anterior-inferior capsular structures. Labral re-attachment and capsulo-ligamentous re-tensioning with suture anchors was performed in all cases with an additional rotator interval closure in four patients and an inferior capsular plication in twelve patients; the bone block screws were removed in eight patients. At an average follow-up of forty-three months (range, twenty-four to seventy-two months), nineteen patients were evaluated by two independent observers. One patient had recurrent subluxation, and two patients had persistent apprehension. Anterior elevation was unchanged, and loss of external rotation (RE1) was 6°. Nine patients returned to sport at the same level; all patients returned to their previous occupations, including the six cases of work-related injury. Eighty-nine percent were satisfied or very satisfied; the subjective shoulder value (SSV) was 83% ± 23%; the Walch-Duplay, Rowe and UCLA scores were 85 ± 21, 81 ± 23 and 30 ± 7 points respectively. The number of previous interventions did not influence the results. Eight patients (42%) were still painful (six with light pain and two with moderate pain). Arthroscopic revision of open anterior shoulder stabilization gives satisfactory results. The shoulders are both stable and functional. While the stability obtained with this approach is encouraging, our enthusiasm is tempered by some cases of persistent pain.
Recent progress of Spectrolab high-efficiency space solar cells (2012)

High-efficiency Inverted Metamorphic (IMM) multi-junction solar cells are being developed at Spectrolab for use in space and near-space applications. Recently, large-area (26-cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ) IMM3J cells achieved a 1-sun, AM0 conversion efficiency of 32% with an open-circuit-voltage of 3.04 V, a short-circuit current-density of 16.7 mA/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , and a fill factor of 0.84. In addition, IMM4J cells (1-cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ) reached a 1-sun, AM0 conversion efficiency of 33%. The 4-junction cell achieved an open-circuit-voltage of 3.42 V, a short-circuit current-density of 15.8 mA/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , and a fill factor of 0.82. Both the inverted metamorphic 3J and 4J cells reveal excellent component subcell quantum efficiency. Improvements in crystal growth, as well as more optimal subcell current density balance, will further raise the 1-sun, AM0 efficiency of the 3J and the 4J IMM cells to 33% and 35% respectively. The latest status of the 72-cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> XTJ (based on 150-mm Ge substrate) Supercells will also be discussed.
EPR Studies on the Addition of Ligated Boryl Radicals to Carbonyl Compounds (2020)

The boron-centered radicals derived from alkenyl <i>N</i>-heterocyclic carbene (NHC)-boranes bearing ester substituents were recently found to ring close in 5-endo mode by addition to the oxygen atoms of the ester substituents. The inference from this was that NHC-boryl radicals might add intermolecularly to carbonyl-containing substrates. Several different NHC-boryl radicals were generated by H-atom abstraction from NHC-ligated trihydroborates. Electron paramagnetic resonance (EPR) spectroscopy proved that these did indeed add to the oxygen atoms of diaryl ketones with production of the corresponding bora-ketyl radicals. The same unusual regioselectivity of addition was observed with monoaryl ketones, but no bora-ketyls were observed with dialkyl ketones. Similarly, no bora-ketyl adduct radicals were observed with esters, even esters of benzoic acid. EPR spectroscopic evidence suggested that NHC-boryl radicals were also added to the O-atoms of aromatic aldehydes. Amine-boryl and phosphine-boryl radicals were also observed to add to the O-atom of benzophenone with production of the corresponding ketyl radicals.
Data from Hypoxia-Inducible Factor-1 Target Genes as Indicators of Tumor Vessel Response to Vascular Endothelial Growth Factor Inhibition (2023)

&lt;div&gt;Abstract&lt;p&gt;Antiangiogenic therapy improves survival in patients with advanced stage cancers. Currently, there are no reliable predictors or markers for tumor vessel response to antiangiogenic therapy. To model effective antiangiogenic therapy, we disrupted the &lt;i&gt;VEGF&lt;/i&gt; gene in three representative cancer cell lines. HCT116 xenografts had low proportions of endothelial tubes covered by pericytes that stained with α-smooth muscle actin (SMA) antibody. Upon disruption of &lt;i&gt;VEGF&lt;/i&gt;, HCT116&lt;sup&gt;&lt;i&gt;VEGF−/−&lt;/i&gt;&lt;/sup&gt; xenografts had significantly decreased tumor microvessel perfusion compared with their parental counterparts. Furthermore, HCT116&lt;sup&gt;&lt;i&gt;VEGF−/−&lt;/i&gt;&lt;/sup&gt; xenografts mounted a tumor-reactive response to hypoxia, characterized by the induction of hypoxia-inducible factor-1 (HIF-1) target genes. One highly induced protein was DPP4, a measurable serum protein that has well-described roles in cancer progression. In contrast, LS174T and MKN45 tumor xenografts had high proportion of endothelial tubes that were covered by SMA+ pericytes. Upon disruption of VEGF, LS174T&lt;sup&gt;&lt;i&gt;VEGF−/−&lt;/i&gt;&lt;/sup&gt; and MKN45&lt;sup&gt;&lt;i&gt;VEGF−/−&lt;/i&gt;&lt;/sup&gt; xenografts maintained tumor microvessel perfusion. As such, there were no changes in intratumoral hypoxia or HIF-1α induction. Together, these data show that the extent of tumor vessel response to angiogenic inhibition could be correlated with (&lt;i&gt;a&lt;/i&gt;) the preexisting coverage of tumor endothelial tubes with SMA+ pericytes and (&lt;i&gt;b&lt;/i&gt;) differential tumor induction of HIF-1 target genes. The data further show that DPP4 is a novel marker of HIF-1 induction. Altogether, these preclinical findings suggest novel clinical trials for predicting and monitoring tumor vessel responses to antiangiogenic therapy. [Cancer Res 2008;68(6):1872–80]&lt;/p&gt;&lt;/div&gt;
Benzeneselenol (2005)

[645-96-5]C6H6Se (MW 157.07) InChI = 1/C6H6Se/c7-6-4-2-1-3-5-6/h1-5,7H InChIKey = WDODWFPDZYSKIA-UHFFFAOYAD (a source of selenolate ions; a selenation reagent for organic halides, alcohols, amines, ethers, alkynes, and carbonyl compounds; a mild reducing agent; a useful radical clock and free radical reagent) Physical Data: bp 73–74 °C/20 mmHg; density: 1.4789 g cm−3 at 20 °C; refractive index: 1.6186 at 589 nm and 20 °C; dipole moment: 1.1 D; IP: 8.3 eV; pKa: 5.9; BDE PhSeH = 67–74 kcal mol−1. Solubility: soluble in benzene, Et2O, THF, acetonitrile; insol H2O, but sol aq NaOH. Preparative Methods: benzeneselenol is synthesized by the reaction of Phenylmagnesium Bromide with metallic Selenium, followed by quenching with aqueous hydrochloric acid.2a Similar hydrolysis of sodium selenolate prepared by the reduction of Diphenyl Diselenide with Sodium Borohydride is a convenient alternative.2b In addition, Phenyl Trimethylsilyl Selenide can be employed as a useful precursor of benzeneselenol upon treating with methanol.2c Benzeneselenol may also be prepared by reduction of diphenyl diselenide with H3PO23 or by reduction of diphenyl diselenide with Bu3SnH (for in situ free radical applications).4 Purification of benzeneselenol is performed by distillation under reduced pressure. 1H NMR (CDCl3) δ 1.54 (PhSeH); 13C NMR (CDCl3) δ 124.46, 126.45, 129.26, 132.71 (PhSeH); 77Se NMR (C6D6) δ −27.7 (PhSeH).4 Handling, Storage, and Precautions: pure benzeneselenol is a colorless liquid, but, on exposure to air, the liquid turns yellow to an extent that depends on the concentration of diphenyl diselenide formed by air-oxidation of PhSeH. Thus, it should be stored under nitrogen in the dark, and is conveniently handled using syringe technique. Use in a fume hood.
Power Handling of Vanadium Dioxide Metal-Insulator Transition RF Limiters (2018)

Maximum power handling, spike leakage, and failure mechanisms have been characterized for limiters based on the thermally triggered metal-insulator transition of vanadium dioxide. These attributes are determined by properties of the metal-insulator material such as on/off resistance ratio, geometric properties that determine the film resistance and the currentcarrying capability of the device, and thermal properties such as heatsinking and thermal coupling. A limiter with greater than 10 GHz of bandwidth demonstrated 0.5 dB loss, 27 dBm threshold power, 8 Watts blocking power, and 0.4 mJ spike leakage at frequencies near 2 GHz. A separate limiter optimized for high power blocked over 60 Watts of incident power with leakage less than 25 dBm after triggering. The power handling demonstrates promise for these limiter devices, and device optimization presents opportunities for additional improvement in spike leakage, response speed, and reliability.
Open EDFA gain spectrum dataset and its applications in data-driven EDFA gain modeling (2023)

Optical networks satisfy high bandwidth and low latency requirements for telecommunication networks and data center interconnection. To improve network resource utilization, machine learning (ML) is used to accurately model optical amplifiers such as erbium-doped fiber amplifiers (EDFAs), which impact end-to-end system performance such as quality of transmission. However, a comprehensive measurement dataset is required for ML to accurately predict an EDFA’s wavelength-dependent gain. We present an open dataset consisting of 202,752 gain spectrum measurements collected from 16 commercial-grade reconfigurable optical add–drop multiplexer (ROADM) booster and pre-amplifier EDFAs under varying gain settings and diverse channel-loading configurations over 2,785 hours in total, with a total dataset size of 3.1 GB. With this EDFA dataset, we implemented component-level deep-neural-network-based EDFA models and use transfer learning (TL) to transfer the EDFA model among 16 ROADM EDFAs, which achieve less than 0.18/0.24 dB mean absolute error for booster/pre-amplifier gain prediction using only 0.5% of the full target training set. We also showed that TL reduces the EDFA data collection requirements on a new gain setting or a different type of EDFA on the same ROADM.
Photoresistive Microring Heater with Resonance Control Loop (2015)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text C. V. Poulton, P. Dong, and Y. Chen, "Photoresistive Microring Heater with Resonance Control Loop," in CLEO: 2015, OSA Technical Digest (online) (Optica Publishing Group, 2015), paper SM2I.3. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Development of Recombinant Immunotoxins for Hairy Cell Leukemia (2020)

Hairy cell leukemia (HCL) is an indolent B-cell malignancy with excellent initial response to purine analogs pentostatin or cladribine, but patients are rarely, if ever, cured. Younger patients will usually need repeat chemotherapy which has declining benefits and increasing toxicities with each course. Targeted therapies directed to the BRAF V600E mutation and Bruton's tyrosine kinase may be helpful, but rarely eradicate the minimal residual disease (MRD) which will eventually lead to relapse. Moxetumomab pasudotox (Moxe) is an anti-CD22 recombinant immunotoxin, which binds to CD22 on HCL cells and leads to apoptotic cell death after internalization and trafficking of the toxin to the cytosol. Phase I testing achieved a complete remission (CR) rate of 57% in relapsed/refractory HCL. Most CRs were without MRD and eradication of MRD correlated with prolonged CR duration. Patients were often MRD-free after five years. Important mild-moderate toxicities included capillary leak and hemolytic uremic syndromes which could be prevented and managed conservatively. A phase 3 trial met its endpoint of durable CR with acceptable toxicity, leading to FDA approval of Moxe for relapsed/refractory HCL, under the name Lumoxiti. Moxe combined with rituximab is currently being evaluated in relapsed/refractory HCL to improve the rate of MRD-free CR.