gebhart/patrepeval huggingface dataset:
Demonstration of an Octave-Bandwidth Negligible-Loss Metamaterial Horn Antenna for Satellite Applications (2012)

This paper reports on the detailed design and experimental demonstration of a metamaterial-enabled low-sidelobe horn antenna (metahorn) based on principles similar to those of earlier soft horn antennas. The target application is a linearly polarized feed horn in the super-extended C-band (3.4-6.725 GHz) for communication satellite reflector antennas. The paper describes the detailed design and manufacturing of the -plane metamaterial liner (metaliner) based on a freestanding wire grid without the need for a dielectric substrate material. The measured copolarized and cross-polarized antenna patterns from the feed horn demonstrate over an octave pattern bandwidth with negligible loss. The results show similar bandwidth with lower sidelobes and backlobes than those of the trifurcated horn that is currently used as the standard C-band feed for single linear polarization. This demonstration shows promise for lightweight metamaterial horns to replace heavy and expensive C-band corrugated horns.
Influence of Clamping Stresses in the Shear Strength of Concrete Slabs Under Uniform Loads (2009)

Experimental results have shown shear capacities of concrete slabs under uniform loads sometimes considerably higher than those predicted by current concrete codes. Vertical compressive stresses transverse to the beam axis, or clamping stresses, are neglected in these analyses. The present study includes results from analytical and experimental research that was conducted to investigate the influence of clamping stresses on the shear strength of concrete slabs under uniform loads. Including clamping stresses in the Modified Compression Field Theory (MCFT) procedures was shown to considerably increase the shear prediction accuracy for members under uniformly distributed loads even for members with short shear spans. In addition, contrary to current sectional methods that give accurate results only in those regions where plane sections remain plane, results suggest that the MCFT with clamping stresses can provide reasonably accurate results in any region of a slab. Shear strength predictions from the MCFT with clamping were verified against 113 experiments from the literature and twelve tests designed and carried out during this work. Additional improvements in predicted shear capacities were achieved when tension stiffening was included in the calculations, an important issue for continuous members in which the shear critical region is close to the inflection point.
Adaptive power allocation for soft frequency reuse in multi-cell LTE networks (2012)

This paper presents a novel power allocation approach for soft frequency reuse (SFR) adopted in a multi-cell LTE network. Based on the fact that major inter-cell interference (ICI) is coordinated by SFR, the proposed power allocation focuses on dealing with mutual interference between cell-edge and cell-center users in the network. It is formulated as an optimization problem, where the performance of cell-edge users is optimized under the condition that desirable performance must be maintained for cell-center users. The optimal solution can be obtained by using the Lagrange decomposition method. Simulation results show that our approach can significantly improve performance of cell-edge users by achieving 20% gain over conventional SFR with average power allocation when higher performance for cell-center users is maintained.
Structure−Activity Relationships for 1-Phenylbenzimidazoles as Selective ATP Site Inhibitors of the Platelet-Derived Growth Factor Receptor (1998)

1-Phenylbenzimidazoles are shown to be a new class of ATP-site inhibitors of the platelet-derived growth factor receptor (PDGFR). Structure-activity relationships (SARs) are narrow, with closely related heterocycles being inactive. A systematic study of substituted 1-phenylbenzimidazoles showed clear SARs. Substituents at the 4'- and 3'-positions of the phenyl ring are tolerated but do not significantly improve activity, while substituents at the 2'-position abolish it. Substituents in the 2-, 4-, and 7-positions of the benzimidazole ring (with the exception of 4-OH) also abolish activity. Most substituents at the 5- and 6-positions maintain or increase activity, with the 5-OH, 5-OMe, 5-COMe, and 5-CO2Me analogues being >10-fold more potent than the parent 1-phenylbenzimidazole. The 5-OMe analogue was both the most potent inhibitor, and showed the highest selectivity (50-fold) between PDGFR and FGFR isolated enzymes, and also a moderately effective inhibitor (IC50 = 1.9 microM) of PDGF-stimulated PDGFR autophosphorylation in rat aorta smooth muscle cells.
Cell division- and DNA replication-free reprogramming of somatic nuclei for embryonic transcription (2021)

Nuclear transfer systems represent the efficient means to reprogram a cell and in theory provide a basis for investigating the development of endangered species. However, conventional nuclear transfer using oocytes of laboratory animals does not allow reprogramming of cross-species nuclei owing to defects in cell divisions and activation of embryonic genes. Here, we show that somatic nuclei transferred into mouse four-cell embryos arrested at the G2/M phase undergo reprogramming toward the embryonic state. Remarkably, genome-wide transcriptional reprogramming is induced within a day, and ZFP281 is important for this replication-free reprogramming. This system further enables transcriptional reprogramming of cells from <i>Oryx dammah</i>, now extinct in the wild. Thus, our findings indicate that arrested mouse embryos are competent to induce intra- and cross-species reprogramming. The direct induction of embryonic transcripts from diverse genomes paves a unique approach for identifying mechanisms of transcriptional reprogramming and genome activation from a diverse range of species.
Centaur: a mobile dexterous humanoid for surface operations (2005)

Future human and robotic planetary expeditions could benefit greatly from expanded Extra-Vehicular Activity (EVA) capabilities supporting a broad range of multiple, concurrent surface operations. Risky, expensive and complex, conventional EVAs are restricted in both duration and scope by consumables and available manpower, creating a resource management problem. A mobile, highly dexterous Extra-Vehicular Robotic (EVR) system called Centaur is proposed to cost-effectively augment human astronauts on surface excursions. The Centaur design combines a highly capable wheeled mobility platform with an anthropomorphic upper body mounted on a three degree-of-freedom waist. Able to use many ordinary handheld tools, the robot could conserve EVA hours by relieving humans of many routine inspection and maintenance chores and assisting them in more complex tasks, such as repairing other robots. As an astronaut surrogate, Centaur could take risks unacceptable to humans, respond more quickly to EVA emergencies and work much longer shifts. Though originally conceived as a system for planetary surface exploration, the Centaur concept could easily be adapted for terrestrial military applications such as de-mining, surveillance and other hazardous duties.
From Reactive Oxygen and Nitrogen Species to Therapy (2009)

Abstract Excessive free radicals, including reactive oxygen species (ROS) and nitric oxide (NO), contribute to pathological production of misfolded proteins, synaptic damage and apoptosis. Misfolded protein aggregates occur in several chronic neurodegenerative disorders, including Parkinson and Alzheimer diseases. In rare cases, the cause is a genetic mutation; the majority is sporadic and may be a response to environmental factors that generate free radicals. Overactivity of the N ‐methyl‐ d ‐aspartate (NMDA)‐subtype of glutamate receptor can generate ROS and NO species that mediate protein misfolding, synaptic damage and apoptosis, and thus, neurodegenerative disease. We review current evidence that excessive ROS and NO contribute to protein misfolding by S ‐nitrosylation of the E3 ubiquitin ligase parkin and protein‐disulfide isomerase . We also discuss NMDA receptor antagonists memantine and NitroMemantine, drugs that block excessive glutamate excitation, thereby limiting production of ROS and NO, and therapeutic electrophiles, drugs that protect cells from oxidative stress by activating the Nrf2 transcriptional pathway. Key Concepts: S ‐nitrosylation or transfer of the NO group to critical cysteine thiol can regulate protein function. Under pathological circumstances, aberrant S ‐nitrosylation reactions can contribute to protein misfolding, neuronal injury and neurodegeneration.
Cardiac Magnetization Transfer Imaging Using SSFP at 3T (2009)

An optimized bSSFP cine sequence was used to calculate magnetization transfer of the myocardium at 3T. MT values of 26% were found in normal myocardium, demonstrating the feasibility of cardiac MT imaging at 3T.
Abstract P352: Reversible Relative FLAIR Signal Intensity Changes in the Penumbra Correlate With Severity of Hypoperfusion (2021)

In ischemic stroke, the study of edema, measurable as fluid attenuated inversion recovery (FLAIR) signal increase, has mainly focused on the ischemic core and less on the surrounding penumbra. To the naked eye, no FLAIR changes are present in the penumbra. However, changes in perfusion status could induce physiological changes resulting in subtle penumbral FLAIR signal alterations. To investigate penumbral FLAIR changes, we included subjects from the Efficacy and Safety of MRI-Based Thrombolysis in Wake-Up Stroke (WAKE-UP) and Granulocyte Colony-Stimulating Factor in Patients With Acute Ischemic Stroke (AXIS 2) trial with perfusion- and diffusion-weighted imaging (PWI, DWI) and FLAIR at baseline. We used RAPID software to calculate the core and perfusion lesion on DWI and PWI and selected subjects with a minimal mismatch volume (15 ml) and ratio (1.2). We created voxel-based relative FLAIR signal intensity (rFLAIR SI) maps at baseline and follow up (FU) by calculating the ratio of the FLAIR intensity in one voxel and the median FLAIR intensity in a sphere with 15 mm radius around a contralateral homologues voxel. We studied rFLAIR SI in two regions of interest: the baseline penumbra (baseline perfusion lesion - [core lesion + voxels with apparent diffusion coefficient &lt;620 10 -6 mm 2 /s]) and the non-infarcted penumbra (baseline perfusion lesion - FU FLAIR lesion) at 24 hours (WAKE-UP) or 30 days (AXIS 2). Severity of hypoperfusion was defined as the time to maximum of the residue function. In the baseline penumbra, rFLAIR SI was elevated (ratio=1.04, p=1.7*10 -13 , n=126) and correlated with severity of hypoperfusion (Pearson’s r 0.03, p&lt;1.0*10 -4 , n=126). At 24 hours in a subgroup from WAKE-UP, rFLAIR SI in the non-infarcted penumbra further increased (ratio=1.05 at 24h vs 1.03 at baseline, p=7.1*10 -3 , n=43). In a different subgroup from AXIS 2, this increase in rFLAIR SI was reversible (ratio=1.02 at 30d vs 1.04 at baseline, p=1.5*10 -3 n=26) since it was no longer different from 1 at 30 days (ratio=1.01 at 30 days, p=0.099, n=26). Increases in rFLAIR SI, likely representing edema, are not restricted to the ischemic core and correlate with severity of hypoperfusion in the penumbra. They appear early after stroke onset, further increase at 24 hours and are reversible by 30 days.
In situ Y 2 Si 2 O 7 coatings on Hi‐Nicalon‐S SiC fibers: Phase formation and fiber strength (2019)

Abstract Y 2 Si 2 O 7 coatings were formed on Hi‐Nicalon‐S SiC fibers by reaction of solution‐derived YPO 4 coatings with glass SiO 2 scales formed by fiber oxidation. Two oxidation methods were used: pre‐oxidation, where fibers were oxidized prior to YPO 4 coating, or post‐oxidation, where fibers were first coated with YPO 4 and then oxidized. Fibers with YPO 4 /SiO 2 films were heat‐treated in argon at 1200°C for 20 hours to react YPO 4 and SiO 2 to Y 2 Si 2 O 7 . The effects of SiO 2 to YPO 4 film thicknesses on fiber strength and on the Y 2 Si 2 O 7 formation kinetics were investigated. An optimized process to obtain single‐phase continuous Y 2 Si 2 O 7 coatings on Hi‐Nicalon‐S fibers with low loss in fiber strength is suggested.
Development of low-maintenance end treatment for concrete barriers (1987)

Due to the character of the original source materials and the nature of batch digitization, quality control issues may be present in this document. Please report any quality issues you encounter to digital@library.tamu.edu, referencing the URI of the item.
Supplementary Table 2 from Novel Potent and Selective Inhibitors of p90 Ribosomal S6 Kinase Reveal the Heterogeneity of RSK Function in MAPK-Driven Cancers (2023)

&lt;p&gt;PDF file - 28K, Percent Inhibition of MDA-MB-231 or H358 cells when grown as colonies on Scivax plates in the presence of LJI308.&lt;/p&gt;
Low cost bifunctional initiators for bidirectional living cationic polymerization of olefins. I. isobutylene Part A Polymer chemistry (2017)

We describe the discovery of novel low cost bifunctional initiators 2,4,7,9‐tetramethyl‐tricyclo[6.2.0.0³⁶]deca‐1(8),2,6‐triene‐4,9‐diol (bBCB‐diOH) and 4,9‐dichloro,2,4,7,9‐tetramethyl‐tricyclo[6.2.0.0³⁶]deca‐1(8),2,6‐triene (bBCB‐diCl), for living cationic bidirectional polymerization of olefins, for example, isobutylene. bBCB‐diOH was quantitatively synthesized in one step by UV radiation of commercially available diacetyl durene (DAD) and bBCB‐diCl by hydrochlorination of bBCB‐diOH. These molecules, in conjunction with TiCl₄ coinitiator, initiate the living polymerization of isobutylene. Livingness was demonstrated by linear conversion versus molecular weight (MW) plots and narrow MW distributions. Polymerizations are slower than those initiated by the universally used “hindered” bifunctional initiator 5‐tert‐butyl‐1,3‐bis(1‐chloro‐1‐methyl)benzene and are suitable for rate studies. Herein, we report the synthesis, by the use of bBCB‐diCl, of relatively low MW (Mₙ   30,000) living PIB telechelics for the synthesis of thermoplastic elastomers. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017, 55, 3716–3724
Structural characterization of sulfoquinovosyl, monogalactosyl and digalactosyl diacylglycerols by FAB-CID-MS/MS (1997)

The glycolipids such as sulfoquinovosyl diacylglycerol (SQDG), isolated from wild-type cyanobacterium Synecho-cystis sp. PCC 6803, and monogalactosyl diacylglycerol (MGDG) and digalactosyl diacylglycerol (DGDG), ob-tained from whole wheat flour, have been investigated by using fast atom bombardment tandem mass spectrometry (FAB-MS/MS). Collision-induced dissociation (CID) of sodium-adduct molecular ions [M-H+2Na]+ from SQDG and [M+Na]+ from MGDG and DGDG generates ions which are characteristic of the structure of the polar head group as well as the fatty acid composition. In particular, the charge-remote fragmentation along the fatty acid chains observed in the high-mass range was useful to locate the double-bond positions. The major component ion ([M-H+2Na]+ at m/z 865) of SQDG contains oleic and palmitic acids at the sn-1 and sn-2 positions, respectively. The predominant molecular ion ([M+Na]+ at m/z 801) of MGDG contains two linoleic acids. One of the two major species of DGDG contains palmitic and linoleic acids ([M+Na]+ at m/z 939) at the sn-1 and sn-2 positions, while the other contains two linoleic acids ([M+Na]+ at m/z 963). The utility of FAB-MS/MS in the structural determination of glycolipids in mixtures of biological origin has been demonstrated. © 1997 John Wiley & Sons, Ltd.
Asymptotically Optimal Pilot Allocation Over Markovian Fading Channels (2017)

We investigate a pilot allocation problem in wireless networks over Markovian fading channels. In wireless systems, the channel state information (CSI) is collected at the base station, in particular, this paper considers a pilot-aided channel estimation method (TDD mode). Typically, there are less available pilots than users, hence at each slot the scheduler needs to decide an allocation of pilots to users with the goal of maximizing the long-term average throughput. There is an inherent tradeoff in how the limited pilots are used: assign a pilot to a user with up-to-date CSI and good channel condition for exploitation, or assign a pilot to a user with outdated CSI for exploration. As we show, the arising pilot allocation problem is a restless bandit problem and thus its optimal solution is out of reach. In this paper, we propose an approximation based on the Lagrangian relaxation method, which provides a low-complexity Whittle index policy. We prove this policy to be asymptotically optimal in the many users regime (when the number of users in the system and the available pilots for channel sensing grow large). We evaluate the performance of Whittle's index policy in various scenarios and illustrate its remarkably good performance for small number of users, where it is not guaranteed to be optimal.
The pulmonary autograft for aortic valve replacement (2018)

When the procedure was initially reported, it was associated with excessive mortality and morbidity. In addition, the surgical technique described was subcoronary implantation of the autograft into the native aortic root, which is considered technically demanding. Some felt it was turning a single valve disease into a double valve disease in the same patient. Hence the adoption rate of the Ross procedure was very low. However, when excellent long-term outcomes were demonstrated, the operation was met with renewed enthusiasm. The introduction of the full aortic root replacement technique, which made early outcomes more predictable than when the subcoronary technique was used, resulted in widespread popularity of the Ross procedure. It was then offered, perhaps unwisely, for almost all types of AV pathology and for a wide age range.
Ultrasensitive Single-Molecule Enzyme Detection and Analysis Using a Polymer Microarray (2018)

This report describes a novel method for isolating and detecting individual enzyme molecules using polymer arrays of picoliter microwells. A fluidic flow-cell device containing an array of microwells is fabricated in cyclic olefin polymer (COP). The use of COP microwell arrays simplifies experiments by eliminating extensive device preparation and surface functionalization that are common in other microwell array formats. Using a simple and robust loading method to introduce the reaction solution, individual enzyme molecules are trapped in picoliter microwells and subsequently isolated and sealed by fluorinated oil. The sealing is stable for hours in the COP device. The picoliter microwell device can measure enzyme concentrations in the low-femtomolar range by counting the number of active wells using a digital read-out. These picoliter microwell arrays can also easily be regenerated and reused.
Oxygen migration during resistance switching and failure of hafnium oxide memristors (2017)

While the recent establishment of the role of thermophoresis/diffusion-driven oxygen migration during resistance switching in metal oxide memristors provided critical insights required for memristor modeling, extended investigations of the role of oxygen migration during ageing and failure remain to be detailed. Such detailing will enable failure-tolerant design, which can lead to enhanced performance of memristor-based next-generation storage-class memory. Here, we directly observed lateral oxygen migration using in-situ synchrotron x-ray absorption spectromicroscopy of HfOx memristors during initial resistance switching, wear over millions of switching cycles, and eventual failure, through which we determined potential physical causes of failure. Using this information, we reengineered devices to mitigate three failure mechanisms and demonstrated an improvement in endurance of about three orders of magnitude.
ChemInform Abstract: Synthesis of 2‐Aryl‐3‐trifluoromethylsulfonylpyrroles. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
On the Use of LVTPNP in ESD Protection Structures (2007)

International audience
New design methdology for megahertz-frequency resonant dc-dc converters using impedance control network architecture (2016)

This paper introduces a new design methodology for high-frequency resonant dc-dc converters utilizing the recently proposed impedance control network (ICN) converter architecture. This design methodology guarantees zero voltage switching (ZVS) and near zero current switching (ZCS) of all transistors across the entire operating range of the converter. As compared to previous ICN converter design techniques, the new methodology does not require frequency adjustment to achieve ZVS. In addition, it uses a rigorous analytical approach to minimize the phase lag required for ZVS, thus ensuring near-ZCS operation. The advantages gained from the proposed design methodology are validated using a prototype 1-MHz 90-W ICN resonant converter designed to operate over an input voltage range of 36 V to 60 V and output voltage of 1.8 V. This prototype ICN resonant converter employs a stacked inverter structure to further enhance performance.
Profiling the dynamics of CSF and plasma Aβ reduction after treatment with JNJ‐54861911, a potent oral BACE inhibitor (2016)

JNJ-54861911, a potent brain-penetrant BACE1 inhibitor, achieved high and stable Aβ reductions after single and multiple dosing in healthy participants.
New Design Paradigm for Color Control in Anodically Coloring Electrochromic Molecules (2019)

A new paradigm is established for the design of conjugated anodically coloring electrochromic molecules. It is shown that through crossconjugation the electronic energy levels of the radical cation state may be controllably tuned independent of the neutral state. It is shown how cross-conjugation can be used to tune the radical cation state independent of the neutral state. Manipulating the oscillator strengths of radical cation transitions allows for tuning of the color by shifting the λ<sub>max</sub> of the low-energy absorption by over 400 nm. The neutral states of these molecules are UV absorbing, providing solutions that are colorless with L*a*b* values of 100, 0, 0. They are oxidized to vibrantly colored radical cations with absorptions that span the visible spectrum, creating green, yellow, and red chromophores. These molecules are then mixed to create transmissive, colorless blends that switch to opaque black solutions.
Figure S4 from Stimulation of Oncogene-Specific Tumor-Infiltrating T Cells through Combined Vaccine and αPD-1 Enable Sustained Antitumor Responses against Established HER2 Breast Cancer (2023)

&lt;p&gt;Supplementary Figure 4&lt;/p&gt;