gebhart/patrepeval huggingface dataset:
Abstract 9911: Hypoxia-inducible Factor-1α Knockout in Myeloid Lineage exaggerates Angiotensin II-induced Abdominal Aortic Aneurysm (2015)

Background: Hypoxia-inducible factor-1α (Hif1α) is a transcriptional factor that regulates various genes reacting hypoxic conditions. In atherosclerotic legion, Hif1α is thought to be regulating inflammatory responses. We previously reported that myeloid specific Proryl hydroxylase domain protein2 deletion had protective effect on cardiovascular disease in animal model. The roll of Hif1α of myeloid lineage in inflammatory response is not determined. Methods and Results: Myeloid specific Hif1α knock out mice (MyHif KO) were created using Cre-lox recombination. MyHif KO mice were crossed with Apolipoprotein E knockout (ApoEKO) mice to create double knock out mice (MyHif/ApoE DKO group, n=18). ApoEKO with Hif1α flox/flox (without Cre recombinase) mice were used as control group (n=11). Two groups were fed with high fat diet (HFD) and infused with Angiotensin II (AII, 1800ng/kg/min) by osmotic mini pump for 4 weeks to promote abdominal aortic aneurysm (AAA) formation. The genotype of mice was blinded during experiment. There was no significant difference in survival rate between two groups. MyHif/ApoE DKO increased AAA formation rate (94.4% vs 81.8% in control) and aortic diameter (2.42mm±0.21mm vs 1.89±0.27mm in control). AAA classification reported by Daugherty et al was significantly exaggerated in MyHif/ApoE DKO group (2.75±0.35 vs 1.63±0.46 in control, P=0.03). Elastin degradation grade was checked by Elastica van Gieson staining. MyHif/ApoE DKO also deteriorated the elastin degradation grade (3.91±0.08 vs 3.25±0.31, P=0.01). The number of macrophages which migrated to abdominal aorta was increased in MyHif/ApoE DKO group (565±110.3/section vs 260.5±136.5/section in control, P=0.0507), whereas MyHif/ApoE DKO did not change the glucose level, blood pressure and body weight. Peritoneal macrophages from MyHif/ApoE DKO were significantly activated the migration induced by monocyte chemotactic protein-1 in dose dependent manner. Conclusion: Hif1α of myeloid lineage might have vascular protective effect via suppressing the macrophage activation in the model of AII-induced AAA in mice.
Scalable Pixel-based Visual Interfaces: Challenges and Solutions (2006)

The information revolution is creating and publishing vast data sets, such as records of business transactions, environmental statistics and census demographics. In many application domains, this data is collected and indexed by geo-spatial location. The discovery of interesting patterns in such databases through visual analytics is a key to turn this data into valuable information. Challenges arise because newly available geo-spatial data sets often have millions of records, or even far more, they are from multiple and heterogeneous data sources, and the output devices have significantly changed, e.g. high-resolution pixilated displays are increasingly available in both wall-sized and desktop units. New techniques are needed to cope with this scale. In this paper, we focus on ways to increase the scalability of pixel-based visual interfaces by adding task on hands scenarios that tightly integrate the data analyst into the exploration of geo-spatial data sets
[P4–134]: INSULIN RESISTANCE IS ASSOCIATED WITH REDUCTIONS IN SPECIFIC COGNITIVE DOMAINS AND INCREASES IN CSF TAU IN COGNITIVELY NORMAL ADULTS (2017)

Growing evidence supports the notion that type 2 diabetes increases the risk of developing dementia. Experimental evidence from mouse models show that the induction of type 2 diabetes/insulin resistance can promote the accumulation of Alzheimer's disease (AD) pathological features. However, the association of type 2 diabetes with pathological and clinical phenotypes in humans is unclear. The overall aim of this study was to investigate if assessments of insulin resistance (HOMA-IR) or pancreatic β-cell function (HOMA-B) are altered across the course of AD and ascertain their associations with pathological and clinical expressions of AD in the Australian Imaging Biomarker and Lifestyle (AIBL) study. In this cross-sectional study, a calculated HOMA-IR index was compared between clinical groups (cognitively normal (CN), mild cognitive impairment (MCI), dementia (AD)) using analysis of covariance (ANCOVA). Associations between HOMA-IR and cognitive composite measures (Verbal Episodic Memory, Visual Episodic Memory, Executive Function, Language and Global composite scores) and pathological markers of AD (CSF Aβ42, CSF T-tau/P-tau, hippocampal volume and neocortical Aβ-amyloid burden), were investigated using linear regression. HOMA-IR (F=7.240, p=0.001) increased across clinical classification being elevated significantly in MCI and AD groups compared to CN. In CN adults higher HOMA-IR was associated with poorer performance on measures of verbal episodic memory (p=0.012), executive function (p=0.048) and global cognitive performance (p=0.008), higher CSF total tau levels (p=0.016). Associations with verbal episodic and global composites, in addition to T-tau, remained significant after correction for the false discovery rate. Together our data suggest that insulin resistance may be a contributing factor to AD development through impacting cognitive performance and accumulation of CSF biomarkers at early preclinical stages of the disease.
Potent vaccine sera target epitopes that overlap the CD4 binding site. (2015)

&lt;p&gt;Selected vaccine sera (1:10 dilution) were competed against various biotinylated monoclonal bnAbs for binding to SOS E168K trimer VLPs by ELISA. E168K+N189A mutant trimer VLPs were used for assays involving biotinylated V2 quaternary mAbs to ensure a full epitope knock in [&lt;a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1004932#ppat.1004932.ref056" target="_blank"&gt;56&lt;/a&gt;]. Three previously mapped HIV-1-infected plasmas were included for reference purposes [&lt;a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1004932#ppat.1004932.ref054" target="_blank"&gt;54&lt;/a&gt;]. These are (epitopes in parentheses) 1702 (some MPER and unmapped nAb), 1686 (predominantly CD4bs nAb) and BB34 (predominantly MPER nAb). Numbers are expressed as the residual % binding titer of biotinylated mAb in the presence of competitor compared to its titer in the presence of a control rabbit prebleed or HIV-1 seronegative human plasma (from donor 210). Each assay was performed at least in duplicate. Standard errors are shown in &lt;a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1004932#ppat.1004932.s008" target="_blank"&gt;S8 Fig&lt;/a&gt;.&lt;/p&gt;
Write System of Blu-ray Disc Drive for Video Camera (2008)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Supplementary Data from Proteomic Screens for Suppressors of Anoikis Identify IL1RAP as a Promising Surface Target in Ewing Sarcoma (2023)

Supplementary Data from Proteomic Screens for Suppressors of Anoikis Identify IL1RAP as a Promising Surface Target in Ewing Sarcoma
High Entropy Spinel Oxide As a Bifunctional Electrocatalyst for Rechargeable Zinc-Air Battery (2022)

Rechargeable zinc-air battery (RZAB) represents one of the ‘beyond-the-lithium-ion’ battery technologies with great potential for renewable energy storage. It is safe, environmentally benign, and excellent potential for affordable applications in resource-limited countries, ranging from residential and industrial electricity supply, transport (e.g., electric vehicles) to mobile and consumer electronics markets. RZABs possess high theoretical specific energy density of 1086 Wh/kg, which is 5 times greater than that of the conventional lithium-ion battery (LIB). The key challenge that conspires against the widespread commercialization of RZAB is the sluggish oxygen reaction kinetics that impedes reversibility of the system. Thus, it has become quite critical to develop low-cost and high-performance bifunctional electrocatalysts for oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) [1,2]. High entropy materials (HEMs) have emerged as electrocatalysts for ORR and OER. HEMs contain five or more metals in equal proportions. Their unique conformational entropy and physico-chemical properties (including lattice distortion, synergistic effects amongst the different metals, and rich defect chemistries) promise to improve the kinetics of ORR / OER and electrochemical cycling stability. In this work, the high entropy spinel oxide, (CoCuFeMnNi) 3 O 4 supported on conductive carbon has been synthesized and characterised using XRD, XPS, HRTEM, SEM and others. Preliminary electrochemistry shows improved ORR/OER kinetics. This presentation will discuss the performance of the initial lab-based RZAB using this electrocatalyst. References AB Haruna and KI Ozoemena, Manganese-based bifunctional electrocatalysts for zinc-air batteries, Opin. Electrochem. 2020, 21, 219-224 AK Ipadeola, AB Haruna, L Gaolatlhe, AK Lebechi, J Meng, QQ Pang, K Eid, AM Abdullah, and KI Ozoemena, Efforts at Enhancing Bifunctional Electrocatalysis and Related Events for Rechargeable Zinc-Air Batteries ; ChemElectroChem 2021, 8, 3998-4018
MFIS Structure Device with a Low Dielectric Constant Ferroelectric Sr2(Ta1−x,Nbx)2O7 Formed by Plasma Physical Vapor Deposition and Oxygen Radical Treatment (2004)

A low dielectric constant ferroelectric Sr2(Ta1 −x,Nbx)2O7 film formation technology which is applied to FFRAM has been developed. The high ferroelectric performance of the STN capacitor has been achieved by plasma physical vapor deposition and microwave-excited (2.45 GHz) high-density (> 1012 cm−3) low electron temperature (< 1 eV) Kr/O2 plasma (oxygen radical treatment). Oxygen radical treatment can oxidize STN effectively at 400°C. Furthermore, we have successfully developed a new technology that crystallizes a ferroelectric material on an insulator layer such as SiO2 and Si3N4 directly by oxygen radical treatment. Using this technology, MFIS device operation has been successfully achieved and its retention time is more than 24 hours.
“Who doesn’t like dinosaurs?” Finding and Eliciting Richer Preferences for Recommendation (2020)

Real-world recommender systems often allow users to adjust the presented content through a variety of preference elicitation techniques such as “liking” or interest profiles. These elicitation techniques trade-off time and effort to users with the richness of the signal they provide to learning component driving the recommendations. In this paper, we explore this trade-off, seeking new ways for people to express their preferences with the goal of improving communication channels between users and the recommender system. Through a need-finding study, we observe the patterns in how people express their preferences during curation task, propose a taxonomy for organizing them, and point out research opportunities. We present a case study that illustrates how using this taxonomy to design an onboarding experience can lead to more accurate machine-learned recommendations while maintaining user satisfaction under low effort.
CTLA4Ig INDUCES REGULATORY T CELLS THAT MEDIATE LINKED REGULATION OF ALLOGENEIC T CELL RESPONSES. (2000)

Lee, Richard S.; Rusche, James R.; Sachs, David H.; Sayegh, Mohamed H.; Madsen, Joren C. Author Information
Differences in the Growth of Aspergillus fumigatus on Cycloheximide Media at Three Temperatures (1973)

Cycloheximide (up to 0.4 g/liter) was significantly more inhibitory to the growth of three isolates of Aspergillus fumigatus at 23 C than at 37 or 45 C. Preincubation of the media for 7 days at 45 C did not alter the inhibitory effect of the cycloheximide at 23 C. Neither mutation nor adaptation in the fungus seems to be the reason for its growth on the antibiotic at the higher temperature. The mechanism for the differences in sensitivity as related to temperature of incubation cannot be explained at this time.
Flows near model otoliths and their implications for fish hearing (2006)

The fish inner ear contains a dense, bony otolith that oscillates in response to acoustic excitation. This relative motion between the otolith and its surrounding fluid generates both steady streaming and unsteady flows in the fluid which in turn displaces the hair cells on the macular membrane. Fish ‘‘hear’’ by interpreting these hair cell displacements. However, most of the hair cells are located near a groove along the otolith (the sulcus), making it likely that the irregular geometric features of the otolith will affect how fish hear by influencing the motions of these hair cells. To understand these acoustically induced flows, magnified otolith models were constructed based upon three-dimensional computer tomography scans of actual otoliths. The model otoliths were sinusoidally oscillated so that steady streaming and unsteady flows could be experimentally studied using particle-image velocimetry. The effect of geometric features like the sulcus was studied near the model surface at various oscillation frequencies, ω, and amplitudes, s. Results will be presented for Reynolds number Re≡ωL2/ν≊1–102 and amplitude ratios ε≡s/L=0.05−−0.2, where L is a representative otolith length scale and ν is the kinematic viscosity of the fluid. [Work supported by ONR.]
Genomic characterization of individuals presenting extreme phenotypes of high and low risk to develop tobacco‐induced lung cancer (2018)

Single nucleotide polymorphisms (SNPs) may modulate individual susceptibility to carcinogens. We designed a genome-wide association study to characterize individuals presenting extreme phenotypes of high and low risk to develop tobacco-induced non-small cell lung cancer (NSCLC), and we validated our results. We hypothesized that this strategy would enrich the frequencies of the alleles that contribute to the observed traits. We genotyped 2.37 million SNPs in 95 extreme phenotype individuals, that is: heavy smokers that either developed NSCLC at an early age (extreme cases); or did not present NSCLC at an advanced age (extreme controls), selected from a discovery set (n = 3631). We validated significant SNPs in 133 additional subjects with extreme phenotypes selected from databases including >39,000 individuals. Two SNPs were validated: rs12660420 (p<sub>combined </sub> = 5.66 × 10<sup>-5</sup> ; OR<sub>combined </sub> = 2.80), mapping to a noncoding transcript exon of PDE10A; and rs6835978 (p<sub>combined </sub> = 1.02 × 10<sup>-4</sup> ; OR<sub>combined </sub> = 2.57), an intronic variant in ATP10D. We assessed the relevance of both proteins in early-stage NSCLC. PDE10A and ATP10DmRNA expressions correlated with survival in 821 stage I-II NSCLC patients (p = 0.01 and p < 0.0001). PDE10A protein expression correlated with survival in 149 patients with stage I-II NSCLC (p = 0.002). In conclusion, we validated two variants associated with extreme phenotypes of high and low risk of developing tobacco-induced NSCLC. Our findings may allow to identify individuals presenting high and low risk to develop tobacco-induced NSCLC and to characterize molecular mechanisms of carcinogenesis and resistance to develop NSCLC.
Evaluation of Optimal Scan Time by Bootstrap Approach for Quantitative Analysis in PET Receptor Study (2006)

Quantification of the receptor binding potential (BP) in human brain has been performed with positron emission tomography. In this quantitative analysis, the uncertainty in estimated kinetic parameters depends on the SNR. Evaluation of the reliability of parameter estimates is important for the optimization of scan protocol and quantitative analysis methods. However, estimating the reliability is not easy for human data because the true noise level is not precisely known. In this study, we have evaluated a method for estimating the reliability of kinetic parameters with a bootstrap approach for both simulated and human data, and applied this method to evaluating the influence of scan time on the error in BP estimated from PET [ <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">11</sup> C]raclopride studies. As a result, it was possible to deduce the reliability of kinetic parameter estimates in region-of-interest analysis of human data using the replicated data generated by bootstrap method. In [ <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">11</sup> C]raclopride studies, the mean estimated BP value did not change when the scan time decreased from 90 to 15 min. However, the uncertainty in BP estimates became larger as the scan time became shorter. With the bootstrap method, it is possible to easily assess the reliability of parameter estimates using only the measured data, and this method can be applied to optimizing scan protocol.
ChemInform Abstract: 2‐Benzopyrylium Salts. Part 45. Interaction of 2‐Benzopyrylium Salts and Their Monocyclic Analogues with Ketone Imines. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
High-Performance, Radiation-Hardened Electronics for Space and Lunar Environments (2008)

The Radiation Hardened Electronics for Space Environments (RHESE) project develops advanced technologies needed for high performance electronic devices that will be capable of operating within the demanding radiation and thermal extremes of the space, lunar, and Martian environment. The technologies developed under this project enhance and enable avionics within multiple mission elements of NASA's Vision for Space Exploration, including the Constellation program's Orion Crew Exploration Vehicle, the Lunar Lander project, Lunar Outpost elements, and Extra Vehicular Activity (EVA) elements. This paper provides an overview of the RHESE project and its multiple task tasks, their technical approaches, and their targeted benefits as applied to NASA missions.
Study on the Effect of Inter-Layer Cooling Time on Porosity and Melt Pool in Inconel 718 Components Processed by Laser Powder Bed Fusion (2023)

This paper investigates the effects on the material microstructure of varying the Inter-Layer Cooling Time (ILCT) during the printing process in laser powder bed fusion (L-PBF) multi-laser machines. Despite these machines allowing higher productivity rates compared to single laser machines, they are affected by lower ILCT values, which could be critical for material printability and microstructure. The ILCT values depend both on the process parameter sets and design choices for the parts and play an important role in the Design for Additive Manufacturing approach in L-PBF process. In order to identify the critical range of ILCT for this working condition, an experimental campaign is presented on the nickel-based superalloy Inconel 718, which is widely used for the printing of turbomachinery components. The effect of ILCT on the microstructure of the material is evaluated in terms of porosity and melt pool analysis on printed cylinder specimens, considering ILCT decreasing and increasing in the range of 22 to 2 s. The experimental campaign shows that an ILCT of less than 6 s introduces criticality in the material microstructure. In particular, at an ILCT value of 2 s, widespread keyhole porosity (close to 1‱) and critical and deeper melt pool (about 200 microns depth) are measured. This variation in melt pool shape indicates a change in the powder melting regime and, consequently, modifications of the printability window promoting the expansion of the keyhole region. In addition, specimens with geometry obstructing the heat flow have been studied using the critical ILCT value (2 s) to evaluate the effect of the surface-to-volume ratio. The results show an enhancement of the porosity value (about 3‱), while this effect is limited for the depth of the melt pool.
Functional scaling beyond ultimate CMOS (2004)

Scaling of CMOS technology is rapidly approaching inviolate limits of size and speed determined by fundamental physics and device density determined by limits of heat dissipation. An analysis presented in this paper shows that the notion of using adiabatic computing ideas suggested by some as a means to lower energy dissipation of charge-based switches is not a viable approach.
An overview of the Photonics Systems Manufacturing Consortium - A participant in the americal institute for manufacturing-integrated photonics institute (2016)

The evolution of the Photonics Systems Manufacturing Consortium (PSMC) and its activities and tentative results are discussed. The PSMC evolved from the long standing optical electronic roadmap activities of the Massachusetts Institute of Technology Micro Photonics Center Communications Technology Roadmap (MIT MPC CTR) and the international Network for Manufacturing Innovation (iNEMI) when these two organization jointly responded to and won a National Institute for Standards and Technology (NIST) RFQ to roadmap photonic integrated circuits and applications in May of 2014. PSMC has made much progress reported herein since then. In July of 2015, the formation of the American Institute for Manufacturing Integrated Photonics (AIM-IP) was announced. Subsequently, PSMC joined AIM-IP and is now expanding its role to include more applications of optical electronics technology. In addition, PSMC is running a series of workshops and seminars to gather information, in the first case, and to educate interested parties in the second case. The near term PSMC objective is to define gaps and technical needs in optical electronic that are, or will become, barriers to utilizing optical technologies in applications. The tentative results as of early December 2015 are reported as well as the intended activities over the next few years. The long term PSMC objective is to contribute to the AIM IP purpose of establishing a self-sustaining institution based on fulfilling the technology needs to enable the growth of optical electronics in data communications, sensors and other applications.
Outage capacity improvements in multicellular CDMA systems using receive antenna diversity and fast power control (2005)

In this paper, we analyze the uplink outage capacity improvements in multicellular code-division multiple-access systems using receive antenna diversity and fast power control schemes that can track multipath fading. The channel is modeled as slowly varying Rayleigh fading with lognormal shadowing and path loss. Closed-form expressions are obtained for the outage capacity of the system by approximating the total intracell and intercell interference distributions. We show that by controlling the power level of a user at the output of the diversity combiner and imposing the condition that a user does not transmit when in a deep fade, the average intercell interference level of the system is significantly reduced. As a result of this reduction, we demonstrate both analytically and through simulations that the outage capacity of the system is improved more than linearly with increasing number of antenna elements.