gebhart/patrepeval huggingface dataset:
Negative Outcomes of Poly( l -Lactic Acid) Fiber-Reinforced Scaffolds in an Ovine Total Meniscus Replacement Model (2016)

Our objective was to test the efficacy of collagen-hyaluronan scaffolds reinforced with poly(l-lactic acid) (PLLA) fibers in an ovine total meniscus replacement model. Scaffolds were implanted into 9 sheep (n = 1 at 8 weeks, n = 2 at 16 weeks, n = 3 at both 24, 32 weeks) following total medial meniscectomy. From 16 weeks on, explants were characterized by confined compression creep, histological, and biochemical analyses. Articular surfaces were observed macroscopically and damage was ranked histologically using the Mankin score. At sacrifice, three of the nine PLLA scaffolds had completely ruptured, and the intact scaffolds experienced progressive shape changes and severe narrowing in the body region at 16, 24, and 32 weeks. Aggregate compressive modulus and permeability did not improve with time. Histological and biochemical analyses showed significantly less extracellular matrix and less matrix organization compared to native tissue. Osteophytes, bone erosion, and cartilage damage were observed, increasing with time postimplantation. A buildup of lactic acid and/or the rapid loss of scaffold mechanical integrity due to PLLA degradation are probable causes for the joint abnormalities observed in this study. These results are in sharp contrast to those of our previous successful total meniscus replacement studies using polyarylate [p(DTD DD)] fiber-reinforced scaffolds. This suggests that PLLA fiber as produced in this study cannot be used as reinforcement for a meniscus replacement scaffold.
Physical modelling of an aeronautical composite in fire (2016)

The evaluation of fire behaviour of structural composites is done through experimental tests which are time consuming and costly for the aircraft manufacturers (e.g. ISO 2685 and burnthrough test). Concurrently, the amount of composites in aircraft structures has increased and each type of material has to be fire evaluated accordingly. Currently, the numerical simulation is largely used during the development phase of an aircraft. So, simulation tools are underdevelopment to predict the thermophysical behaviour of composite exposed to fire. Hence it is paramount to explore in detail the behaviour of composites upon fire in order to secure the design and the certification tests to match with the aircraft master planning.
Quantum Dots: Blue Liquid Lasers from Solution of CdZnS/ZnS Ternary Alloy Quantum Dots with Quasi‐Continuous Pumping (Adv. Mater. 1/2015) (2015)

A blue (ca. 440 nm) whisper gallery mode laser in the liquid phase is realized by employing unconventional ternary CdZnS/ZnS alloyed-core/shell quantum dots. Detailed optical studies on page 169 by H. V. Demir, H. D. Sun, and co-workers indicate that such laser devices benefit from the high-quality-factor whispering gallery mode resonators and the novel gain media with minimal defects, suppressed Auger recombination, and large gain cross-section.
Supplementary Figure 1 from BRCA1 Represses Amphiregulin Gene Expression (2023)

Supplementary Figure 1 from BRCA1 Represses Amphiregulin Gene Expression
CETP (2017)

High-density lipoproteins are involved in reverse cholesterol transport and possess anti-inflammatory and antioxidative properties. Paradoxically, CETP (cholesteryl ester transfer protein) inhibitors have been shown to increase inflammation as revealed by a raised plasma level of high-sensitivity C-reactive protein. CETP inhibitors did not improve clinical outcomes in large-scale clinical trials of unselected patients with coronary disease. Dalcetrapib is a CETP modulator for which effects on cardiovascular outcomes were demonstrated in the dal-OUTCOMES trial to be influenced by correlated polymorphisms in the <i>ADCY9</i> (adenylate cyclase type 9) gene (<i>P</i>=2.4×10<sup>-8</sup> for rs1967309). Patients with the AA genotype at rs1967309 had a relative reduction of 39% in the risk of presenting a cardiovascular event when treated with dalcetrapib compared with placebo (95% confidence interval, 0.41-0.92). In contrast, patients with the GG genotype had a 27% increase in risk, whereas heterozygotes (AG) presented a neutral result. Supporting evidence from the dal-PLAQUE-2 study using carotid ultrasonography revealed that the polymorphisms tested in the <i>ADCY9</i> linkage disequilibrium block were associated with disease regression for patients with the protective genotype, progression for the harmful genotype, and no effect in heterozygotes (<i>P</i>≤0.05 and ≤0.01 for 10 and 3 polymorphisms, respectively) when comparing dalcetrapib to placebo. Strikingly concordant and significant genotype-dependent effects of dalcetrapib were also obtained for changes in high-sensitivity C-reactive protein and cholesterol efflux capacity. The Dal-GenE randomized trial is currently being conducted in patients with a recent acute coronary syndrome bearing the AA genotype at rs1967309 in the <i>ADCY9</i> gene to confirm the effects of dalcetrapib on hard cardiovascular outcomes.
Saccharomyces boulardii CNCM I-745 supplementation during and after antibiotic treatment positively influences the bacterial gut microbiota (2023)

In this study, we provide a comprehensive analysis of how probiotic yeast administration can influence the fungal and bacterial microbiota in a model of broad-spectrum antibiotherapy.
Monitoring Morphology and Hydrogen Coverage of Nanometric Pt/γ‐Al2O3 Particles by In Situ HERFD–XANES and Quantum Simulations (2014)

Platinum nanoclusters highly dispersed on γ-alumina are widely used as heterogeneous catalysts. To understand the chemical interplay between the Pt nanoparticles, the support, and the reductive atmosphere, we performed X-ray absorption near edge structure (XANES) in situ experiments recorded in high energy resolution fluorescence detection (HERFD) mode. Spectra are assigned by comparison with simulated XANES spectra on models obtained by molecular dynamics (DFT-MD). We propose platinum cluster morphologies and quantify the hydrogen coverages compatible with XANES spectra recorded at variable hydrogen pressures and temperatures. Using cutting-edge methodologies to assign XANES spectra, this work gives unequalled atomic insights into the characterization of supported nanoclusters.
Booster immunotherapy (BIT) (1994)

This study tries to answer two questions: 1) how long does the therapeutic effect of successful immunotherapy (IT) last after termination of the treatment? and 2) what is the best treatment for recidivist patients? To answer the first question, we asked 108 patients with rye/grass pollen allergy who had previously undergone IT for 3-4 years and had responded well to treatment to complete a questionnaire on the course of their recovery after termination of the therapy. Evaluation of the answers revealed a recidivist rate of approximately 30% in the first 3 years. According to our results, the risk of a relapse after this period seems to be low. To answer the second question, we included 40 patients suffering from type I allergy to grass/rye pollen in a clinical study. Each of them had previously undergone specific IT with a grass pollen extract mixture and had terminated this therapy after 3-4 years practically free of symptoms during the grass pollen season. As the symptoms returned and increased from year to year after the end of IT, new therapeutic steps had to be considered. We investigated the efficacy of a short preseasonal injection treatment called "booster immunotherapy" (BIT). BIT was performed with two different injection-regimens, a low-dose schedule comprising six injections and a high-dose schedule with 11 injections, in both cases administered as a build-up regimen. In the next pollen season, 28/40 (70%) patients reported strong improvement or even complete remission of the allergy symptoms.(ABSTRACT TRUNCATED AT 250 WORDS)
Batch-assembled multi-level micromachined mechanisms from bulk silicon (1992)

The authors report on the development of a new technology intended for the wafer level fabrication and assembly of fully integrated micromechanisms. The technology is based on a boron-doped bulk silicon dissolved wafer process that has been used to fabricate a variety of micromechanical devices. The overall process utilizes three wafers: two silicon and one glass. All the major mechanical elements, including gears and micromotors, are fabricated from one silicon wafer, whereas the mechanical links between these elements are fabricated from a second silicon wafer. These wafers are successively aligned and bonded to a glass wafer which forms the substrate and are then dissolved in EDP to free the mechanisms. This procedure permits wafer-level batch assembly of micromechanical systems. A number of bulk silicon electrostatic micromotors 5-10 mu m thick and gear trains have been fabricated and linked to each other on the same chip.
Special feature on imaging systems and techniques (2013)

The IEEE International Conference on Imaging Systems and Techniques (IST'2012) was held in Manchester, UK, on 16–17 July 2012. The participants came from 26 countries or regions: Austria, Brazil, Canada, China, Denmark, France, Germany, Greece, India, Iran, Iraq, Italy, Japan, Korea, Latvia, Malaysia, Norway, Poland, Portugal, Sweden, Switzerland, Taiwan, Tunisia, UAE, UK and USA. The technical program of the conference consisted of a series of scientific and technical sessions, exploring physical principles, engineering and applications of new imaging systems and techniques, as reflected by the diversity of the submitted papers. Following a rigorous review process, a total of 123 papers were accepted, and they were organized into 30 oral presentation sessions and a poster session. In addition, six invited keynotes were arranged. The conference not only provided the participants with a unique opportunity to exchange ideas and disseminate research outcomes but also paved a way to establish global collaboration.
2,3-DPG and Erythrocyte Oxygen Affinity (1974)

Preclinical evidence has firmly established bidirectional interactions among the brain, the gut, and the gut microbiome. Candidate signaling molecules and at least three communication channels have been identified. Communication within this system is ...Read More
Terahertz interferometric synthetic aperture tomography for confocal imaging systems (2012)

Terahertz (THz) interferometric synthetic aperture tomography (TISAT) for confocal imaging within extended objects is demonstrated by combining attributes of synthetic aperture radar and optical coherence tomography. Algorithms recently devised for interferometric synthetic aperture microscopy are adapted to account for the diffraction-and defocusing-induced spatially varying THz beam width characteristic of narrow depth of focus, high-resolution confocal imaging. A frequency-swept two-dimensional TISAT confocal imaging instrument rapidly achieves in-focus, diffraction-limited resolution over a depth 12 times larger than the instrument's depth of focus in a manner that may be easily extended to three dimensions and greater depths.
Formation of a nanogroove-striped NiO surface using atomic steps (2006)

A nanogroove-striped pattern was formed on a NiO film surface. The periodic nanopattern was successfully obtained over the entire surface via high-temperature annealing of the epitaxial NiO thin film, which was grown on an atomically stepped sapphire substrate at low temperature. The depth, width and interval of straight nanogrooves were about 3 nm, 35 nm and about 100 nm, respectively. The periodicity of the stripe agrees well with that of the atomic steps of the substrate.
New molecular targets for the treatment of sarcoidosis (2016)

Rising morbidity and mortality rates for patients with sarcoidosis strongly support the need to develop more effective anti-inflammatory therapies to treat chronic disease.
CO-ADMINISTRATION OF AZATHIOPRINE AND ALLOPURINOL IN A PATIENT WITH INFLAMMATORY BOWEL DISEASE AND GOUT: AN INDICATION FOR 6-THIOGUANINE NUCLEOTIDE MONTIORING (2003)

s Submitted for the 68th Annual Scientific Meeting of the American College of Gastroenterology October 10-15, 2003, Baltimore, Maryland: CLINICAL VIGNETTES: PDF Only
Performance estimation of fully digital polar modulation driving a 2 GHz switch-mode power amplifier (2012)

This paper presents a fully digital transmitter architecture based on a digital polar modulator (DPM) and switch-mode power amplifier (SMPA). A simple method for comparison and estimation of different digital modulation techniques for SMPA is described. An estimation of the proposed digital polar modulator properties was done by means of a 2.1..2.2 GHz class-F power amplifier. For a CDMA signal with 9.5 dB peak-to-average power ratio (PAPR), the class-F based amplifier module driven by DPM pulse train shows more than 1 W output power and more than 10 % of drain efficiency.
The emergency department arrival mode and its relations to ED management and 30-day mortality in acute heart failure: an ancillary analysis from the EURODEM study (2022)

Most acute heart failure patients arrive at ED by EMS. These patients suffer from more severe respiratory distress and receive more often ventilatory support. EMS use is an independent predictor of 30-day mortality.
Interaction of septin 7 and DOCK8 in equine lymphocytes reveals novel insights into signaling pathways associated with autoimmunity (2018)

The GTP-binding protein septin 7 is involved in various cellular processes, including cytoskeleton organization, migration and the regulation of cell shape. Septin 7 function in lymphocytes, however, is poorly characterized. Since the intracellular signaling role of septin 7 is dependent on its interaction network, interaction proteomics was applied to attain novel knowledge about septin 7 function in hematopoietic cells. Our previous finding of decreased septin 7 expression in blood-derived lymphocytes in ERU, a spontaneous animal model for autoimmune uveitis in man, extended the role of septin 7 to a potential key player in autoimmunity. Here, we revealed novel insights into septin 7 function by identification of DOCK8 as an interaction partner in primary blood-derived lymphocytes. Since DOCK8 is associated with important immune functions, our finding of significantly decreased DOCK8 expression and altered DOCK8 interaction network in ERU might explain changes in immune response and shows the contribution of DOCK8 in pathomechanisms of spontaneous autoimmune diseases. Moreover, our analyses revealed insights in DOCK8 function, by identifying the signal transducer ILK as a DOCK8 interactor in lymphocytes. Our finding of the enhanced enrichment of ILK in ERU cases indicates a deviant influence of DOCK8 on inter- and intracellular signaling in autoimmune disease.
IDENTIFICATION OF TRACE ELEMENT–CONTAINING PROTEINS IN GENOMIC DATABASES (2004)

Development of bioinformatics tools provided researchers with the ability to identify full sets of trace element-containing proteins in organisms for which complete genomic sequences are available. Recently, independent bioinformatics methods were used to identify all, or almost all, genes encoding selenocysteine-containing proteins in human, mouse, and Drosophila genomes, characterizing entire selenoproteomes in these organisms. It also should be possible to search for entire sets of other trace element-associated proteins, such as metal-containing proteins, although methods for their identification are still in development.
[Secondhand smoke exposure and its influencing factors among Chinese people aged 15 years and above in 2010 and 2018]. (2022)

<b>Objective:</b> To investigate secondhand smoke (SHS) exposure among non-current smokers aged 15 and over and its influencing factors in China in 2010 and 2018. <b>Methods:</b> The 2010 and 2018 China Adult Tobacco Surveys used multistage stratified cluster random sampling methods to obtain national representative samples across 31 provinces (autonomous regions and municipalities) in China. This study selected non-current smokers aged 15 and over as the research subjects to describe the general demographic characteristics, perceptions of SHS hazards, attitudes towards smoking bans in indoor areas in public places, and SHS exposure and the smoking restriction regulations in different places. The Rao-Scott <i>χ</i><sup>2</sup> test was used to compare the rates, and the unconditional logistic regression was used to analyze the influencing factors of SHS exposure. All the subjects in the analysis were weighted based on a complex sampling design. <b>Results:</b> Among non-current smokers aged 15 and over, from 2010 to 2018, the percentage of indoor smokers had decreased from 84.7% to 71.9%. The rates of people who saw smoking in various places declined with a statistically significant difference (<i>P</i><0.001). The exposure to SHS for females, people aged 45-64, teachers, medical staff, workers in enterprises, businesses, waiters, and people who live in rural and central areas declined. The differences were statistically significant (<i>P</i><0.05). In 2018, the percentage of SHS exposure for those who reported a comprehensive smoking ban in households or allowed smoking in certain areas was lower than for those who reported allowed or without a smoking ban. Among those aged 25-44, SHS exposure for those who reported complete smoking prohibition in workplaces was lower than those who reported allowed or without smoking prohibition (<i>OR</i>=0.65, 95%<i>CI</i>: 0.49-0.87). The proportion of SHS exposure for those who believe that smoking should not be allowed in indoor areas of 0-5 public places is higher than that smoking should not be allowed in the indoor spaces of 8 public places (<i>OR</i>=2.13, 95%<i>CI</i>: 1.35-3.36). Among people aged 45-64, the proportions of SHS exposure for teachers (<i>OR</i>=0.37, 95%<i>CI</i>: 0.17-0.78) and medical staff (<i>OR</i>=0.35, 95%<i>CI</i>: 0.16-0.76) and staff working in agriculture, forestry, animal husbandry, fishery, and water conservancy were lower than governmental staff (<i>OR</i>=0.49, 95%<i>CI</i>: 0.29-0.84). <b>Conclusions:</b> Data from the decreased exposure of Chinese non-current smokers aged 15 and over to SHS suggests the initial achievement through constructing a smoke-free environment, but continued efforts are needed. It is necessary to actively advocate for smoke-free families, strengthen publicity and education on the hazards of tobacco and SHS, and improve the skills of non-smokers in rejecting SHS exposure.
Effect of Different DNA Demethylating Agents on In vitro Cultures of Peach Rootstock GF 677 (2019)

The appearance of somaclonal variability induced by in vitro cultivation is relatively frequent and, in some cases, provides a valuable source of new phenotypes suitable for crop improvement. Numerous studies have confirmed that these changes can be explained by alterations of DNA methylation. Interestingly, a group of chemical compounds termed ‘demethylating agents’ (DMT agents) enable artificial changes to be made in the DNA methylation state. Thus, these agents are theoretically able to induce new phenotypes or more favourable properties. The objective of the present study was to verify suitable conditions for the application of different DMT agents within in vitro protocols for micropropagation using the stone fruit rootstock GF 677 as an example. The impact of these agents on the properties of plant regenerants was evaluated, and their DNA methylation state was controlled by using an AFLP protocol based on a restriction endonuclease that differed in its sensitivity to methylated cytosines. Moreover, the effect of newly synthesised derivates was compared with that of conventional compounds with a well-documented DNA-demethylating impact. Based on the results, the suitable concentration for treatment by a DMT agent was established as approximately 50 µM. Promising results were generated using a combination of DMT agents with different mechanisms of action, such as azacytidine and dihydroxypropyladenine; under these conditions, probable synergy between methyltransferase interception by the cytosine analogue and interruption of methyl group donation by dihydroxypropyladenine significantly changed the DNA methylation state of treated plants. Regarding newly synthesised compounds, the 5,6-dihydro-5-azacytosine nucleoside showed the most promising results, which can likely be explained by its higher stability in the media used for in vitro cultivation. ********* In press - Online First. Article has been peer reviewed, accepted for publication and published online without pagination. It will receive pagination when the issue will be ready for publishing as a complete number (Volume 47, Issue 3, 2019). The article is searchable and citable by Digital Object Identifier (DOI). DOI link will become active after the article will be included in the complete issue. *********
Lubricant Oxidation Monitoring Using FTIR Analysis - Application to the Development of a Laboratory Bulk Oxidation Test and to In-Service Oil Evaluation (2003)

&lt;div class="htmlview paragraph"&gt;This paper describes a methodology using FTIR analysis for monitoring the degradation by oxidation of lubricants. This methodology is based on the interpretation of the viscosity increase and of the carbonyl compounds formation measured by Peak Area Increase (PAI). This physicochemical approach was applied to the development of an innovative in-house bulk oxidation test, the Modified ICOT, and to in-service oil evaluation. This work provided the opportunity to confirm hypotheses and gave new information on the oxidation process of lubricants, especially concerning catalytic action of soluble iron and relationship between viscosity increase and carbonyl compounds formation. Laboratory test results showed a good correlation between PAI and TAN on bulk-oxidized oils, in which acidity is only related to the carbonyl compounds formed during the oxidation. Considering in-service engine oil samples, PAI gives complementary information to TAN on the degradation of the lubricant caused by oxidation. PAI measurements on used oil samples from TU5JP engine test showed that oxidation was not the principal factor governing thickening in this test.&lt;/div&gt;
A Dynamic Accelerator-Cluster Architecture (2012)

Accelerators such as graphics processing units (GPUs) provide an inexpensive way of improving the performance of cluster systems. In such an arrangement, the individual nodes of the cluster are directly connected to one or more accelerator devices via PCI Express. This results in a static mapping of accelerators onto compute nodes, where each accelerator can only be accessed from exactly one compute node. While this static mapping enables efficient data transfers between a given accelerator and the compute node it belongs to, differing computational demands across jobs may, however, produce either underutilized accelerators or nodes whose computational demands cannot be satisfied with the number of accelerators available to them. In particular, smaller numbers of GPUs available per node may enforce explicit MPI parallelism across compute nodes where it is not necessary. To address this limitation, we propose a novel accelerator-cluster architecture in which network-attached accelerators are dynamically assigned to compute nodes. This allows not only their optimal utilization but also a more precise match between application requirements and accelerator hardware. We outline the general concept of our dynamic architecture and show that it can offer substantial benefits to certain classes of applications without significantly harming the performance of others.
Lasing operation under pulsed optical pumping of 1.55 μm external-cavity VCSELs using an InP/AlGaInAs bottom Bragg reflector (2003)

We present half vertical cavity surface emitting lasers (VCSELs), based on a new type of InP/AlGaInAs distributed Bragg reflector (DBR) and on InAlAs/AlGaInAs DBR. Lasing effect under pulsed optical pumping in external cavity configuration was obtained. A comparison between these two materials systems is presented, as well as a first step in the design of the active cavity in order to optimize the absorption for the optical pumping.