gebhart/patrepeval huggingface dataset:
Systemic delivery of a DUX4-targeting antisense oligonucleotide to treat facioscapulohumeral muscular dystrophy (2021)

Facioscapulohumeral muscular dystrophy (FSHD) is one of the most prevalent skeletal muscle dystrophies. Skeletal muscle pathology in individuals with FSHD is caused by inappropriate expression of the transcription factor DUX4, which activates different myotoxic pathways. At the moment there is no molecular therapy that can delay or prevent skeletal muscle wasting in FSHD. In this study, a systemically delivered antisense oligonucleotide (ASO) targeting the DUX4 transcript was tested <i>in vivo</i> in ACTA1-MCM;FLExDUX4 mice that express DUX4 in skeletal muscles. We show that the DUX4 ASO was well tolerated and repressed the DUX4 transcript, DUX4 protein, and mouse <i>DUX4</i> target gene expression in skeletal muscles. In addition, the DUX4 ASO alleviated the severity of skeletal muscle pathology and partially prevented the dysregulation of inflammatory and extracellular matrix genes. DUX4 ASO-treated ACTA1-MCM;FLExDUX4 mice performed better on a treadmill; however, the hanging grid and four-limb grip strength tests were not improved compared to control ASO-treated ACTA1-MCM;FLExDUX4 mice. This study shows that systemic delivery of ASOs targeting DUX4 is a promising therapeutic strategy for FSHD and strategies that further improve the ASO efficacy in skeletal muscle are warranted.
Staged Total Hip Arthroplasty: A Novel Technique in Managing Native and Periprosthetic Acetabular Insufficiency (2021)

Staged total hip arthroplasty can be used to address pelvic discontinuity with excellent short- to mid-term outcomes. This technique allows for a more limited exposure and the use of primary hip implants. Fixation is by ingrowth and does not rely on intact pelvic architecture.
Quantum Dots Color Converters for microLEDs: Material Composite and Patterning Technology (2020)

We demonstrated high-resolution pixelated quantum dots (QDs)/thiol-ene photopolymer color converters patterned by projection lithography on microLEDs. The material composite and patterning technology enable high-efficiency, wide-gamut and low cross-talk color conversion compared to drop-cast QDs.
Effect of Oxygen plasma treatment on the performance of GaN-based MIS-HEMTs (2022)

We have studied the effects of oxygen plasma treatment prior to insulator deposition on the electrical performance of AlGaN/GaN metal-insulator-semiconductor high-electron-mobility transistors (MIS-HEMTs). Devices treated with oxygen plasma exhibit more positive threshold voltages, less hysteresis in transfer curves and higher peak transconductance values compared with reference devices without oxygen plasma treatment. Our results suggest that oxygen plasma treatment of the AlGaN surface before insulator deposition can improve the overall electrical performance of GaN-based MIS-HEMTs.
The role of early baseline computed tomography in the interpretation of morphological changes after kidney-pancreas transplantation (1993)

In a prospective study, 17 early baseline computed tomography (CT) scans were obtained 2 or 3 days after simultaneous kidney-pancreas transplantation. Morphological changes and their relevance to the early detection of graft rejection and complications were evaluated. The pancreatic grafts were enlarged and showed signs of mild pancreatitis. Serial scans obtained during the first renal graft rejection episode were compared with the baseline CT scans (n = 7). They showed a significant increase in pancreatic graft size in the case of biopsy-proven severe renal graft rejection (P = 0.008). Normally functioning pancreatic allografts showed a 15%-40% decrease in size 1-6 months after transplantation. We conclude that the morphological changes observed early after transplantation are compatible with mild pancreatitis, which may contribute to the development of pancreatic graft thrombosis. There is an increase in the number of morphological changes during severe rejection, yet enlarged pancreatic grafts appear to recover from transplantation-related damage and regain their normal size without signs of atrophy.
Design of the IBM z14 microprocessor (2018)

The latest-generation IBM Z processor provides enhanced performance and compute capacity compared to its IBM z13 predecessor. This paper describes some of the major improvements that include an additional perceptron branch predictor, a completely redesigned translation engine that is tightly integrated into the core pipeline, and an integrated level-1 cache directory and translation lookaside buffer design. Outside of the central processing unit (CPU), the cache sizes have increased on each cache level, and each processor chip now contains 10 CPUs. The system topology has been optimized to improve cache transfer latencies for workloads spanning multiple processor chips. The bus interfaces between the chips have been redesigned to improve peak bus traffic handling. In combination, these enhancements provide significant performance improvements in traditional data-serving workloads, as well as in virtualized Linux environments running database, analytic, and cognitive workloads.
Role of caspase‐8 in hepatocyte response to infection and injury in mice† (2007)

These findings indicate that caspase-8 participates in regulation of the cellular response to infection and injury and that it does so by affecting various cellular functions, including cell death, cell proliferation, and induction of inflammation.
Authenticated Broadcast with a Partially Compromised Public-Key Infrastructure. (2009)

Abstract. Given a public-key infrastructure (PKI) and digital signatures, it is possible to construct broadcast protocols tolerating any number of corrupted parties. Almost all existing protocols, however, do not distinguish between corrupted parties (who do not follow the protocol), and honest parties whose secret (signing) keys have been compromised (but who continue to behave honestly). We explore conditions under which it is possible to construct broadcast protocols that still provide the usual guarantees (i.e., validity/agreement) to the latter. Consider a network of n parties, where an adversary has compromised the secret keys of up to tc honest parties and, in addition, fully controls the behavior of up to ta other parties. We show that for any fixed tc&amp;gt; 0, and any fixed ta, there exists an efficient protocol for broadcast if and only if 2ta + min(ta, tc) &amp;lt; n. (When tc = 0, standard results imply feasibility.) We also show that if tc, ta are not fixed, but are only guaranteed to satisfy the bound above, then broadcast is impossible to achieve except for a few specific values of n; for these “exceptional ” values of n, we demonstrate a broadcast protocol. Taken together, our results give a complete characterization of this problem. 1
A music scene analysis system with the MRF-based information integration scheme (1996)

This paper describes the process model for a system that recognizes the rhythm, chords, and source-separated musical notes in monaural music signals. The model consists of multiple processing modules and a MRF (Markov random field)-based hypothesis network for integration of multiple sources of information. Because the MRP enables information to be integrated on a multiply connected hypothesis network, the results of evaluation experiments show that the present system recognizes notes better than does a system based on a singly connected Bayesian hypothesis network.
Novel Approach for Clinical Validation of the cobas KRAS Mutation Test in Advanced Colorectal Cancer (2016)

The cobas test showed similar accuracy to the therascreen test for detecting KRAS mutations and could appropriately identify mCRC patients ineligible for anti-EGFR therapy as demonstrated by bridging analysis results.
Twist inversion in a cholesteric material containing a single chiral centre (1992)

A novel liquid-crystalline material, S-2-chloropropyl 4′-(4″-n-nonyloxyphenylpropioloyloxy)biphenyl-4-carboxylate (902C13T), which undergoes an inversion of helical-twist sense in the cholesteric phase, was prepared and its physical properties were investigated. The behaviour of the pitch and the twist sense of the helical structure in the cholesteric phase are reported. It is suggested that the helix inverts because of changes in the populations of conformational isomers, and that these changes are temperature dependent. An equation that was originally formulated to account for an inversion in the sign of the spontaneous polarization (Ps) in certain smectic C* materials may be adapted for the modelling of helix inversions.
Action of hydrogen sulfide on aminoalkanethiosulfuric acids (Bunte salts) to give di-, tri-, and tetrasulfides (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAction of hydrogen sulfide on aminoalkanethiosulfuric acids (Bunte salts) to give di-, tri-, and tetrasulfidesDaniel L. Klayman, David Kenny, Richard B. Silverman, Joseph E. Tomaszewski, and Robert J. ShineCite this: J. Org. Chem. 1971, 36, 24, 3681–3686Publication Date (Print):December 1, 1971Publication History Published online1 May 2002Published inissue 1 December 1971https://pubs.acs.org/doi/10.1021/jo00823a005https://doi.org/10.1021/jo00823a005research-articleACS PublicationsRequest reuse permissionsArticle Views206Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The a locus governs cytoduction in Ustilago maydis (1992)

We have developed a cytoduction assay to measure cell fusion quantitatively in the basidiomycete corn smut fungus Ustilago maydis. This assay employs a mutation conferring resistance to oligomycin that exhibits non-Mendelian inheritance and presumably affects the mitochondrial genome. After auxotrophic olir cells are mixed with prototrophic olis cells, prototrophic olir cells can be detected at a significant frequency after several hours of incubation, reaching a maximum of 10% of the total prototrophs in the mixture after 18 h. We demonstrate that this cell fusion event occurs only if the mating partners have different alleles of the a mating-type locus and is not influenced by the b locus. These studies support the view that the a locus but not the b locus controls establishment of the filamentous, pathogenic state.
Transient thermal behavior of SOIC packages — an optimization study (2016)

Under a given set of boundary conditions, thermal performance of an electronic system is generally evaluated based on its steady state response. It is a conventional practice that actual time dependent power cycles and thermal boundary conditions are time-averaged to estimate the steady state characteristics. This approach may produce accurate results provided that the time dependency of the power cycles and/or thermal boundary conditions is small. In general, time-dependent thermal analyses with actual time-dependent boundary conditions and power cycles should be performed in order to determine the steady state behavior. Whether an experimental or numerical approach is taken, accurate prediction of transient thermal behavior of complex electronic systems is time consuming. While being less overwhelming compared to the actual laboratory experiments, fully time dependent Computational Fluid Dynamics (CFD) analysis still requires large amount of CPU time. In order to prevail over this large computational cost, a number of approximate models were developed, such as Resistor-Capacitor (R-C) thermal network approaches which have produced reasonably accurate results, and therefore have been popular in determining system transient response. It is worth noting that these approaches require some rigorous curve-fitting effort followed by an optimization process and are applicable to relatively simple systems. The present study uses state-space model to determine transient and steady state thermal behavior of complex systems as accurately as possible without compromising the speed. The aforementioned technique is applied to a “Small Outline Integrated Circuit” (SOIC) package placed on a printed circuit board (PCB) and the results are compared to those from the fully transient CFD model computations. With a dramatic reduction in the overall CPU times, the temperature histories obtained from the state-space approach agree well with the transient CFD simulations. Furthermore, an optimization scheme is defined so that the maximum temperature on the package is kept under a specified value by changing the power cycles on individual die elements which may be of great benefit to the chip designers especially at the early stages of design.
Two-Locus Linkage Analysis in Multiple Sclerosis (MS) (1994)

One of the major challenges in genetic linkage analyses is the study of complex diseases. We demonstrate here the use of two-locus linkage analysis in multiple sclerosis (MS), a multifactorial disease with a complex mode of inheritance. In a set of Finnish multiplex families, we have previously found evidence for linkage between MS susceptibility and two independent loci, the myelin basic protein gene (MBP) on chromosome 18 and the HLA complex on chromosome 6. This set of families provides a unique opportunity to perform linkage analysis conditional on two loci contributing to the disease. In the two-trait-locus/two-marker-locus analysis, the presence of another disease locus is parametrized and the analysis more appropriately treats information from the unaffected family members than single-disease-locus analysis. As exemplified here in MS, the two-locus analysis can be a powerful method for investigating susceptibility loci in complex traits, best suited for analysis of specific candidate genes, or for situations in which preliminary evidence for linkage already exists or is suggested.
Creating advanced functions on network processors: experience and perspectives (2003)

In this article we present five case studies of advanced networking functions that detail how a network processor (NP) can provide high performance and also the necessary flexibility compared with ASIC. We first review the basic NP system architectures, and describe the IBM PowerNP architecture from the data plane as well as the control plane point of view. We introduce models for the programmer's views of NP that facilitate a global understanding of NP software programming. Then, for each case study, we present results from prototypes as well as general considerations that apply to a wider range of system architectures. Specifically, we investigate the suitability of NP for QoS (active queue management and traffic engineering), header processing (GPRS tunneling protocol), intelligent forwarding (load balancing without flow disruption), payload processing (code interpretation and just-in-time compilation in active networks), and protocol stack termination (SCTP). Finally, we summarize the key features as revealed by each case study, and conclude with remarks on the future of NP.
A 3.3V 6b 100kS/s current-steering D/A converter using organic thin-film transistors on glass (2011)

Organic thin-film transistors (OTFT) processed at low-temperatures offer prospects for a vast number of integrated circuit applications in mechanically flexible, inexpensive, large-area and biomedical electronics. In addition, the low-voltage operation capability of recent OTFTs makes them well-suited for battery-powered or radio frequency-coupled portable devices. In such applications, data conversion to interface the digital processors with the analog world is an essential necessity. Here, we demonstrate a compact 6b current-steering D/A converter (DAC) circuit, built in OTFT technology, which is 1000χ faster and 30χ smaller than the previously published data for a 6b DAC. These considerable improvements result from an OTFT fabrication process based on silicon stencil masks that provide submicron channel length capability and excellent transistor matching.
Effects of Plant Hormones on Formation of Scopoletin and Scopolin in Tobacco Tissue Cultures (1982)

The addition of 2,4-dichlorophenoxyacetic acid (2,4-D), indoleacetic acid (IAA) and benzylaminopurine (BAP) increased the quantity of scopoletin and scopolin during the exponential growth phase. 2,4-D greatly increased the quantity of scopolin in cells. Naphthaleneacetic acid (NAA) and kinetin caused the accumulation of scopoletin in the medium during non-growth phase. The combination of NAA and BAP was more effective for formation of scopoletin and scopolin than the use of either hormone alone. 2,4-D stimulated the incorporation of scopoletin from the culture medium into the cells and the conversion of scopoletin to scopolin. The stimulatory action of 2,4-D was inhibited by KCN, but not by cycloheximide.
Revisiting Serial Arithmetic: A Performance and Tradeoff Analysis for Parallel Applications on Modern FPGAs (2015)

Serial arithmetic cores reduce area compared to bit-parallel alternatives, but are generally assumed to be inappropriate for high-performance FPGA applications due to a significant reduction in throughput. In this paper, we perform a performance and tradeoff analysis of Xilinx 7-series specialized architectures for a novel serial adder tree and multiplier. We show that these serial arithmetic architectures significantly improve functional density due to an average 2x clock speedup compared to bit-parallel alternatives, which provides attractive tradeoffs for different usage scenarios. We also show that serial arithmetic can surprisingly provide better performance than bit-parallel alternatives when replication is solely limited by an area constraint and not application parallelism or input bandwidth. We evaluate this performance improvement on several highly parallel sliding-window applications, showing average speedups of 4.8x and 4.4x compared to bit-parallel implementations over a variety of area constraints.
Prioritization in the Policy of Integrated Medicine that Uses the Delphi Method and Analytic Hierarchy Process (2015)

The purpose of the study is to establish priorities in integrated medicine policy. Delphi method was used in conducting a survey on integrated medicine specialists regarding the policies of integrated medicine and actions. For specialists in integrated medicine, total 17 persons selected included scholars who performed minimum one study on integrated medicine, medical staff who performing integrated medical service at institutions that implemented integrated medical care or those who were involved in creating or implementing policies on integrated medicine. The first Delphi-method survey conducted from Apr. 14 through 18, while the second survey was carried out from Apr. 21 through 25. To prioritize the policies based on the results of the mini Delphi-method survey, Analytic Hierarchy Process(AHP) was performed for 15 persons answered to mini Delphi-method from May 2 through 16, 2014. From the Delphi-method survey, four policies and 16 actions were obtained. AHP showed the first priority placed on ‘Building the Infrastructure of Industrialization in the Integrative medicine’ of the 4 policies and ‘Developing new diagnostic and treatment instruments’ was given the highest priority of the 16 actions. For implementation of integrated medicine policy, the 4 policies and the 16 actions found in this research require government support and should be urgently implemented according to its priority.
Simvastatin inhibits the MHC class II pathway of antigen presentation by impairing Ras superfamily GTPases (2006)

Statins are widely used hypocholesterolemic drugs that inhibit 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, a rate-limiting enzyme of the mevalonate pathway whose biosynthetic endproduct is cholesterol. As a result of this activity, statins may perturb the composition of cell membranes, resulting in lipid raft disruption. Furthermore, by inhibiting protein prenylation, a process also dependent on mevalonate, statins block membrane targeting and activity of small GTPases. Antigen uptake, processing and presentation involve the interplay of Rab and Rho family GTPases. Furthermore, lipid rafts have been implicated both in antigen internalization by the BCR and in MHC class II clustering at the immunological synapse. Here we have addressed the effects of simvastatin on antigen processing and presentation by human B cells and dendritic cells. The results show that simvastatin potently suppresses tetanus toxoid processing and presentation to CD4+ T cells by HLA-DR by inhibiting protein antigen uptake through both receptor-mediated endocytosis and macropinocytosis. This effect can be largely accounted for by defective prenylation of Rho and Rab GTPases in the absence of any measurable perturbation of lipid rafts. In addition, simvastatin was found to preferentially affect the invariant chain-dependent MHC class II pathway, thereby identifying this route of antigen processing and presentation as a selective target of statins.
Bioprinted Notch ligand to function as stem cell niche improves muscle regeneration in dystrophic muscle (2023)

299In Duchenne muscular dystrophy, dystrophic muscle phenotypes are closely associated with the exhaustion of muscle stem cells. Transplantation of muscle stem cells has been widely studied for improving muscle regeneration, but poor cell survival and self-renewal, rapid loss of stemness, and limited dispersion of grafted cells following transplantation have collectively hindered the overall success of this strategy. Optimized mechanisms for maintaining and improving stem cell function are naturally present in the microenvironment of the stem cell niche in healthy muscles. Therefore, one logical strategy toward improving stem cell function and efficiency of stem cell transplantation in diseased muscles would be the establishment of a microenvironment mimicking some key aspects of healthy native stem cell niches. Here, we applied inkjet-based bioprinting technology to engineer a mimicked artificial stem cell niche in dystrophic muscle, comprising stem cell niche regulating factors (Notch activator DLL1) bioprinted onto 3D DermaMatrix construct. The recombinant DLL1 protein, DLL1 (mouse): Fc (human) (rec), was applied here as the Notch activator. Bioprinted DermaMatrix construct was seeded with muscle stem cells <i>in vitro</i>, and increased stem cell maintenance and repressed myogenic differentiation process was observed. DLL1 bioprinted DermaMatrix construct was then engrafted into dystrophic muscle of <i>mdx</i>/<i>scid</i> mice, and the improved cell engraftment and progression of muscle regeneration was observed 10 days after engraftment. Our results demonstrated that bioprinting of Notch activator within 3D construct can be applied to serve as muscle stem cell niche and improve the efficacy of muscle stem cell transplantation in diseased muscle.