gebhart/patrepeval huggingface dataset:
CFD Simulation of a Spray including Particle‐Droplet Interaction (2011)

Abstract Die Herstellung von Formteilen und Dämmstoffen aus modifizierten Polyurethanschäumen im Sprühverfahren hat in den letzten Jahren einen deutlichen Zuwachs erfahren. Hierbei werden Füllstoffe wie Glasfasern oder Metallpartikel in den Sprühstrahl eingebunden, um die gewünschten Produkteigenschaften zu erzielen. Die vorliegende Arbeit widmet sich der numerischen Simulation (CFD) der Sprühstrahlausbreitung unter besonderer Berücksichtigung der Einbindung von Partikeln in den Sprühstrahl. Experimentelle Untersuchungen an einer Sprühversuchsanlage zeigen, dass die hier vorgestellte Methode eine realitätsnahe Vorhersage der Partikeleinbindung in einen Sprühstrahl erlaubt.
Imaging Pharmacodynamics of the α-Folate Receptor–Targeted Thymidylate Synthase Inhibitor BGC 945 (2008)

The assessment of tissue-specific pharmacodynamics is desirable in the development of tumor-targeted therapies. Plasma deoxyuridine (dUrd) levels, a measure of systemic thymidylate synthase (TS) inhibition, has limited application for studying the pharmacodynamics of novel TS inhibitors targeted to the high affinity alpha-folate receptor (FR). Here, we have evaluated the utility of [(18)F]fluorothymidine positron emission tomography ([(18)F]FLT-PET) for imaging the tissue pharmacodynamics of BGC 945, an FR-targeted antifolate TS inhibitor; the nontargeted antifolate BGC 9331 was used for comparison. TS inhibition by both drugs induced a concentration-dependent increase in [(3)H]thymidine uptake in FR-positive human epidermoid KB cells. Membrane-associated equilibrative nucleoside transporter type 1 levels increased from 55,720 +/- 6,101 to 118,700 +/- 5,193 and 130,800 +/- 10,800 per cell at 100 mug/mL of BGC 9331 and BGC 945, respectively, suggesting this as a potential mechanism of increased nucleoside uptake. In keeping with these in vitro findings, tumor [(18)F]FLT accumulation in KB xenografts increased by >/=2-fold after drug treatment with maximal levels at 1 to 4 hours and 4 to 24 hours after BGC 9331 and BGC 945 treatment, respectively. Of interest to FR targeting, BGC 9331, but not BGC 945, induced accumulation of [(18)F]FLT uptake in intestine, a proliferative and TS-responsive tissue. For both drugs, quantitative changes in tumor [(18)F]FLT uptake were associated with increased tumor dUrd levels. In conclusion, we have validated the utility of [(18)F]FLT-PET to image TS inhibition induced by antifolates and shown the tumor-specific activity of BGC 945. This imaging biomarker readout will be useful in the early clinical development of BGC 945.
Effect of intraarterial papaverine and/or angioplasty on the cerebral veins in patients with vasospasm after subarachnoid hemorrhage due to ruptured intracranial aneurysms (2006)

Endovascular treatment produces measurable increases in intracranial venous diameters. However, these changes do not correlate with changes in ICP.
Highly Emitting Concomitant Polymorphic Crystals of a Dinuclear Rhenium Complex (2010)

The dinuclear complex [Re(2)(μ-Cl)(2)(CO)(6)(μ-4,5-(Me(3)Si)(2)pyridazine)] gives in the solid state two polymorphs (yellow, 1Y, and orange, 1O), which can be either concomitantly or separately obtained on varying the crystallization rate. Both crystal phases exhibit intense photoluminescence from the lowest lying triplet metal-to-ligand charge transfer state, much stronger than in solution (quantum yields 0.56 and 0.52, for 1O and 1Y respectively, vs 0.06 in toluene), likely due to the restricted rotation of the Me(3)Si groups in the solid state. A clean, irreversible 1O → 1Y single-crystal-to-single-crystal phase transition occurs at 443 K, as revealed by variable temperature X-ray diffraction analysis. In spite of the absence of any strong intermolecular interactions in both forms, 1O and 1Y show very different absorption and emission maxima (λ(abs) 370 and 393 nm, λ(em) 534 and 570 nm, for 1Y and 1O, respectively). This behavior highlights the importance of the local organization of molecular dipoles in perturbing the photophysical properties of the molecule in the crystal.
Optimal low power interconnect networks (2002)

Because interconnect capacitance represents the dominant load capacitance in CMOS VLSI systems, dynamic power dissipation is largely determined by multilevel wiring requirements. Using a newly derived stochastic interconnect distribution, a model for total on-chip power dissipation is developed. With this new model, the optimal interconnect dimensions for a multilevel network can be determined that minimize chip size and power drain.
Time-Reversal Processing for Downlink-Limited Passive UHF RFID in Pulsed Wave Mode (2019)

This letter provides experimental evidence that, in a complex environment, a time-reversal processing of electromagnetic waves can increase the energy efficiency of the reader to tag communication and, hence, can increase the activation range of a passive ultrahigh frequency (UHF) radio frequency identification (RFID) system. A first experiment performed in a free-space environment shows that in addition to the classical continuous wave (CW) mode, a type AD222 passive UHF RFID tag can successfully operate in a pulsed wave (PW) mode using pulses with half-width 5 ns and period 35 ns. In a second experiment performed in a complex multipath environment, it is shown that the energy efficiency of the RFID system in the PW mode can be increased by applying a time-reversal (TR) processing strategy. Furthermore, it is shown that both PW and TR strategies involve less energy to activate the tag than the classical CW mode does. As a consequence, given a fixed amount of energy, TR processing can increase the activation range of the RFID system.
Supramolecular Nanocarrier of Anionic Dendrimer Porphyrins with Cationic Block Copolymers Modified with Polyethylene Glycol to Enhance Intracellular Photodynamic Efficacy (2004)

Photocytotoxisch und stabil ist das polymere Micellensystem, das in wässrigem Medium durch elektrostatische Assoziation aus einem anionischen dendrimeren Porphyrin und einem Polyethylenglycol-Poly(L-lysin)-Blockcopolymer entsteht (siehe Bild). Wegen seiner hydrodynamischen Größe (ca. 60 nm) sollte sich dieses polymere Micellensystem für die intravenöse Verabreichung bei der photodynamischen Tumortherapie eignen.
Development of a Copper-Catalyzed Thiopyridyl Ester Synthesis and Application to the Total Synthesis of Halichondrin B 1020 (2023)

We present an efficient coupling of alkyl halides with 2,2'-dithiopyridyl carbonate to synthesize thiopyridyl esters, valuable building blocks in the preparation of ketones, amides and esters. This reaction is catalyzed by low-valent copper-mediated alkyl radical generation and typically proceeds in high yields (up to 96% yield; 26 examples) with good functional group tolerance. This methodology was showcased in the first total synthesis of halichondrin B 1020 and facilitated a divergent synthesis of the latently symmetrical left half spiroketal.
Managed Pressure Drilling in Marine Environments – Case Studies (2005)

Abstract In around 340 BC, Plato wrote in The Republic, "Necessity, who is the mother of invention." Such is the case of a relatively new offshore drilling technology – Managed Pressure Drilling (MPD), a technology that addresses a litany of issues associated with drilling into "trouble zones". Drilling-related issues such as excessive mud cost, differentially stuck pipe and resulting well control situations associated with loss circulation issues contribute to defining the necessity for a more efficient drilling technology. A kick-Loss scenario, which may occur when drilling into narrow downhole pressure environments, is another. Drilling-related flat time further indicate a necessity for a technology that enables more precise wellbore pressure management when drilling in marine environments. These challenges to economic drill-ability apply to a growing percentage of offshore prospects for oil and gas, becoming more troublesome and costly with water depth. These challenges have one thing in common - they all may be addressed to some degree or other with more precise wellbore pressure management. Dictated: A technology that offers more precise pressure management with fewer interruptions to drilling ahead.
Bioluminescence Resonance Energy Transfer 2 (BRET2)‐Based RAS Biosensors to Characterize RAS Inhibitors (2019)

Protein-protein interactions (PPIs) are principle biological processes that control normal cell growth, differentiation, and homeostasis but are also crucial in diseases such as malignancy, neuropathy, and infection. Despite the importance of PPIs in biology, this target class has been very challenging to convert to therapeutics. In the last decade, much progress has been made in the inhibition of PPIs involved in diseases, but many remain difficult such as RAS-effector interactions in cancers. We describe here a protocol for using Bioluminescence Resonance Energy Transfer 2 (BRET2)-based RAS biosensors to detect and characterize RAS PPI inhibition by macromolecules and small molecules. This method could be extended to any other small GTPases or any other PPIs of interest. © 2019 by John Wiley & Sons, Inc.
Biomechanical Assessment of a Distally Fixed Lateral Extra-articular Augmentation Procedure in the Treatment of Anterolateral Rotational Laxity of the Knee (2019)

A distally fixed lateral extra-articular augmentation procedure provides an alternative to a proximally fixed LET and can reduce anterolateral laxity in the anterolateral capsule-injured knee and restore kinematics close to the intact state.
Unconventional Transport through Graphene on SrTiO3: A Plausible Effect of SrTiO3 Phase-Transitions (2014)

High-k dielectric oxides are supposedly ideal gate-materials for ultra-high doping in graphene and other 2D-crystals. Here, we report a temperature-dependent electronic transport study on chemical vapor deposited-graphene gated with SrTiO₃ (STO) thin film substrate. At carrier densities away from charge neutrality point the temperature-dependent resistivity of our graphene samples on both STO and SiO₂/Si substrates show metallic behavior with contributions from Coulomb scattering and flexural phonons attributable to the presence of characteristic quasi-periodic nano-ripple arrays. Significantly, for graphene samples on STO substrates we observe an anomalous 'slope-break' in the temperature-dependent resistivity for T = 50 to 100 K accompanied by a decrease in mobility above 30 K. Furthermore, we observe an unusual decrease in the gate-induced doping-rate at low temperatures, despite an increase in dielectric constant of the substrate. We believe that a complex mechanism is at play as a consequence of the structural phase transition of the underlying substrate showing an anomalous transport behavior in graphene on STO. The anomalies are discussed in the context of Coulomb as well as phonon scattering.
Complete genome sequence of and proposal of Thermofilum uzonense sp. nov. a novel hyperthermophilic crenarchaeon and emended description of the genus Thermofilum (2015)

Abstract A strain of a hyperthermophilic filamentous archaeon was isolated from a sample of Kamchatka hot spring sediment. Isolate 1807-2 grew optimally at 85 °C, pH 6.0-6.5, the parameters being close to those at the sampling site. 16S rRNA gene sequence analysis placed the novel isolate in the crenarchaeal genus Thermofilum ; Thermofilum pendens was its closest valid relative (95.7 % of sequence identity). Strain 1807-2 grew organothrophically using polysaccharides (starch and glucomannan), yeast extract or peptone as substrates. The addition of other crenarchaea culture broth filtrates was obligatory required for growth and could not be replaced by the addition of these organisms’ cell wall fractions, as it was described for T. pendens . The genome of strain 1807-2 was sequenced using Illumina and PGM technologies. The average nucleotide identities between genome of strain 1807-2 and T. pendens strain HRK 5 T and “ T. adornatus ” strain 1910b were 85 and 82 %, respectively. On the basis of 16S rRNA gene sequence phylogeny, ANI calculations and phenotypic differences we propose a novel species Thermofilum uzonense with the type strain 1807-2 T (= DSM 28062 T = JCM 19810 T ). Project information and genome sequence was deposited in Genbank under IDs PRJNA262459 and CP009961, respectively.
Supplementary Figure 3 from Reversal of NK-Cell Exhaustion in Advanced Melanoma by Tim-3 Blockade (2023)

&lt;p&gt;PDF file - 72K, Fig. S3. MD NK cells are functionally impaired/exhausted.&lt;/p&gt;
Further Evaluation of Spur Gear Tooth Profile Designs Used in Heavily Loaded Transmissions (2011)

Aerospace applications require special procedures for component design and manufacturing. Spur gears of different designs, because of their simpler geometries, are used in vital units-transmissions of helicopters and alike aerospace vehicles. In this study, performances of various profile designs of previously researched low and high contact ratio spur gears with some realistic design parameters are studied. Effects of the realistic parameters of variable tooth pair stiffness, relief shape, and adjacent pitch error on Transmission Error (TE), tooth loads and root stresses are presented; composition of these parameters determines the efficiency of the gearbox assembly. Detail of minimization of tooth root stress through optimized/proper design of relief is described. More comprehensive comparison of the gear tooth profile design cases is done to be able to guide aerospace transmission designers for practical applications with realistic parameters for each of the design cases. A preference order is done among the design cases, depending on effect of some design parameters on the results such as tooth loads, tooth root stresses, TE curves and peak-to-peak TE values.
Properties of Ga1-xInxN Films Prepared by MOVPE (1989)

Epitaxial films of the solid solution Ga 1- x In x N (up to X =0.42) have been fabricated on (0001) sapphire substrates by metalorganic vapor phase epitaxy (MOVPE) at 500°C. The properties of the films have been studied by the reflection high-energy electron diffraction technique, X-ray diffraction, and electrical and optical measurements. The fundamental absorption edge of the film decreases linearly with composition (up to X =0.42) from 3.20 eV to 2.01 eV at room temperature.
Correction to: Impact of whole dairy matrix on musculoskeletal health and aging–current knowledge and research gaps (2020)

The article Impact of whole dairy matrix on musculoskeletal health and aging-current knowledge and research gaps written by N.R.W. Geiker, C. Mølgaard, S. Iuliano, R. Rizzoli,Y. Manios, L.J.C. van Loon, J.-M. Lecerf, G. Moschonis, J.-Y. Reginster, I. Givens, A. Astrup.
Theory of surface phonons in amorphous silica (1978)

A new theoretical approach to studying surface vibrations in amorphous solids is applied to silicon dioxide. The method entails modeling the surface as a Bethe lattice with a dangling bond, and treating the two-dimensional nature of the surface and the surface topography as small perturbations. The theory successfully describes the nature and origin of the surface states, as well as their relative intensities as observed in recent infrared-reflectivity and Raman-scattering experiments. Both intrinsic surface effects and those caused by the presence of adsorbates are discussed.
Synthesis and biological evaluation of 2,3-bis(het)aryl-4-azaindole derivatives as protein kinase inhibitors (2011)

The synthesis of several novel 4-azaindoles was carried out by novel Fischer reaction which offers as a main advantage, the synthesis of the bisfunctionalized 4-azaindolic building block in one step. The final compounds were evaluated on a panel of 5 kinases in order to evaluate their selectivity and on 7 cancer cell lines to determine their cytotoxic effects. RAF-1 and DYRK1A inhibitions were found, docking studies explain fully the results.
Supplementary Movie from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches (2023)

&lt;p&gt;JAK2-PK&lt;/p&gt;
Biometric Knowledge Extraction for Multi-factor Authentication and Key Exchange (2015)

Abstract This paper describes a method for achieving strong, multi-factor and mutual authentication from a biometrics-based protocol for authenticated key exchange (B-AKE). Operation of the protocol relies on knowledge shared by communicating parties, extracted from data collected by biometric sensors. A Diffie-Hellman key-agreement scheme creates a symmetric encryption key using a weak secret, the extracted something-you-know data. This key protects the confidentiality of user credentials and other message data transferred during operation of the B-AKE protocol. If the message recipient possesses the same something-you-know information as the sender, a key is created, the message decrypted, and mutual authentication achieved. Biometric match data recovered from the encrypted message provides a second something-you-are authentication factor. The B-AKE protocol ensures users never reveal their knowledge or biometric credentials to imposter recipients or man-in-the-middle observers. Diffie-Hellman key establishment provides forward secrecy , a highly desirable protocol property, when participants choose fresh random values each time they operate the protocol.
Catalyst Residence Time Distributions in Riser Reactors for Catalytic Fast Pyrolysis. Part 2: Pilot-Scale Simulations and Operational Parameter Study (2017)

Using the validated simulation model developed in part one of this study for biomass catalytic fast pyrolysis (CFP), we assess the functional utility of using this validated model to assist in the development of CFP processes in fluidized catalytic cracking (FCC) reactors to a commercially viable state. Specifically, we examine the effects of mass flow rates, boundary conditions (BCs), pyrolysis vapor molecular weight variation, and the impact of the chemical cracking kinetics on the catalyst residence times. The factors that had the largest impact on the catalyst residence time included the feed stock molecular weight and the degree of chemical cracking as controlled by the catalyst activity. Because FCC reactors have primarily been developed and utilized for petroleum cracking, we perform a comparison analysis of CFP with petroleum and show that the operating regimes are fundamentally different.
Liver Cytosol Corticosteroid Binder II, a Hormone Receptor (1973)

Abstract Of four protein fractions previously reported which bind corticosteroids in liver cytosol, one fraction, corticosteroid Binder II, has been found to be a major hormone receptor. It has a molecular weight of 67,000 determined by gel filtration. Binder II has an appropriate glucocorticoid binding specificity: dexamethasone g corticosterone g cortisol >> cortisone >> deoxycorticosterone and it also binds progesterone and to a lesser extent the sex hormones. The Kd for dexamethasone is about 6 x 10-10 m determined in vitro and that for cortisol is in the range of 10-8 m. Binder II bound with corticosteroid is deduced to undergo nuclear transfer in vitro and in vivo as determined by its reisolation from the soluble nuclear fraction. The reisolated nucleoplasmic macromolecule has characteristics similar to corticosteroid Binder II isolated from liver cytosol (molecular weight, chromatographic elution position and pI (6.7) determined by isoelectric focusing). An antibody has been prepared to corticosteroid Binder II fraction isolated from cytosol which does not cross-react with other corticosteroid binding proteins (ligandin, Binder III and transcortin) and an antigen, determined by gel immunodiffusion, is present in the soluble nuclear fraction after nuclear transfer of macromolecular bound steroid in vitro or in vivo.
Variational transition state for the reaction of Cl2C: with ethylene and the thermodynamics of carbene additions (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVariational transition state for the reaction of Cl2C: with ethylene and the thermodynamics of carbene additionsJames F. Blake, Scott G. Wierschke, and William L. JorgensenCite this: J. Am. Chem. Soc. 1989, 111, 5, 1919–1920Publication Date (Print):March 1, 1989Publication History Published online1 May 2002Published inissue 1 March 1989https://pubs.acs.org/doi/10.1021/ja00187a078https://doi.org/10.1021/ja00187a078research-articleACS PublicationsRequest reuse permissionsArticle Views136Altmetric-Citations61LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
The Increase in Hepatic Uncoupling by Fenofibrate Contributes to a Decrease in Adipose Tissue in Obese Rats (2007)

Fenofibrate is a drug that has been suggested to inhibit weight gain by increasing the catabolism of fatty acid in the hepatic mitochondria. We hypothesized that fenofibrate induces an increase in energy expenditure in the hepatic mitochondria, which results in the reduction of adipose tissue. In this study we measured hepatic uncoupling protein (UCP)-2, -3, core temperatures and abdominal fat composition with MRI in Otsuka Long-Evans Tokushima Fatty rats. The fenofibrate group (n=7) was fed fenofibrate (320 mg/kg) mixed chow. The control group (n=7) was fed chow only. The body weight (531.6+/-7.6 g) of the fenofibrate group was significantly lower than that (744.3+/-14.9 g) of the control group (p<0.005). The areas of visceral and subcutaneous fat in the fenofibrate group (11.0+/-0.9 cm(2), 4.2+/-0.3 cm(2)) were significantly less than those in the control group (21.0+/-0.7 cm(2), 7.4+/-0.4 cm(2)) (p=0.046, respectively). The esophageal and rectal temperatures of the fenofibrate group (37.7+/-0.1 degrees C, 33.1+/-0.2 degrees C) were significantly higher than those of the control group (37.3+/-0.1 degrees C, 32.2+/-0.1 degrees C) (p=0.025, p=0.005). There was de novo expression of UCP-3 in the liver of the fenofibrate group. These data suggest that increased energy dissipation, via hepatic UCP-3 by fenofibrate, contribute to decreased weight gain in obese rats.