gebhart/patrepeval huggingface dataset:
The physical source of adherent microbubble signal separation in singular spectrum-based targeted molecular imaging (SiSTM) of large vessels (2012)

Real-time ultrasound-based molecular imaging in large vessels has the promise for early detection and diagnosis of stroke. Isolation of echo signals from adherent microbubbles (AMBs) from signals attributed to free microbubbles and tissue structures is critical to the success of these imaging techniques. Singular spectrum-based targeted molecular imaging (SiSTM) is a recently proposed method that uses changes in statistical dimensionality, as quantified by the normalized singular spectrum area (NSSA), to more effectively separate components compared with methods that use frequency-domain filtering alone. However, the precise physical mechanism responsible for NSSA-based signal separation of AMBs and vessel wall is still unknown. In this paper, in vitro flow phantom experiments were performed to elucidate the physical mechanism responsible for NSSA-based separation. NSSA and image intensity of AMBs were measured with different radiation forces, microbubble concentrations and flow rates. In the absence of flow, NSSA shifts between vessel wall and AMBs with increasing radiation force and microbubble concentration were less than 2.5% and 10% of typical values (i.e. ∼ 0.2) observed from SiSTM, respectively. With flow, and thus with shear forces, the NSSA shift between vessel wall and AMBs was close to 0.2. With different flow rates, the steady-state NSSA level increased with higher flow shear forces. Consequently, our results indicate that the physical source responsible for NSSA-based signal separation is shear forces from flow.
A High‐Temperature Neutron Diffraction and First‐Principles Study of Ti 3 AlC 2 and Ti 3 ( Al 0.8 Sn 0.2 ) C 2 (2013)

Herein, we report on the temperature‐dependent crystal structures of Ti 3 AlC 2 and Ti 3 Al 0.8 Sn 0.2 C 2 in the 373–1273 K temperature range, as determined by Rietveld analysis of high‐temperature neutron diffraction time‐of‐flight data. The compositions are 86(1) wt% Ti 3 AlC 2 and 14(1) wt% TiC 0.92(2) for the sample with no Sn , and 95(1) wt% Ti 3 ( Al 0.8 Sn 0.2 ) C 2 and 5(1) wt% Ti 2 AlC for the solid solution with Sn . The average linear volumetric thermal expansion is 8.0(2) × 10 −6 K − 1 for Ti 3 AlC 2 and 8.2(5) × 10 −6 K −1 for Ti 3 ( Al 0.8 Sn 0.2 ) C 2 . The average linear thermal expansion in the a and c directions, respectively, are 7.6(2) × 10 −6 K −1 and 8.9(2) × 10 −6 K −1 for Ti 3 AlC 2 . For Ti 3 ( Al 0.8 Sn 0.2 ) C 2 , the respective values are 8.0(5) × 10 −6 K −1 and 8.6(6) × 10 −6 K −1 . In the case of the solid solution, the quadratic thermal expansion coefficients are also given. Detailed bond lengths analysis shows that the thermal expansions along the a and c directions are controlled by the thermal expansions of the Ti – C , and Ti – Al bond lengths, respectively. The atomic displacement parameters (ADPs) show that the Al and Sn atoms vibrate with a higher amplitude than the Ti and C atoms. Consistent with first‐principles calculations, the ADPs of the Al/Sn site(s) in Ti 3 ( Al 0.8 Sn 0.2 )
WDM/SDM transmission of 10 x 128-Gb/s PDM-QPSK over 2688-km 7-core fiber with a per-fiber net aggregate spectral-efficiency distance product of 40,320 km⋅b/s/Hz (2012)

We demonstrate 2688-km multi-span transmission using wavelength-division multiplexing (WDM) of ten 50-GHz spaced 128-Gb/s PDM-QPSK signals, space-division multiplexed (SDM) in a low-crosstalk 76.8-km seven-core fiber, achieving a record net aggregate per-fiber-spectral-efficiency-distance product of 40,320 km·b/s/Hz. The demonstration was enabled by a novel core-to-core signal rotation scheme implemented in a 7-fold, synchronized recirculating loop apparatus.
Distribution of antibiotic resistance gene against Streptococcus parauberis isolated from cultured olive flounder (Paralichthys olivaceus) in Jeju, South Korea (2023)

Abstract Common bacterial diseases in the olive flounder Paralichthys olivaceus , a commercially important fish species, are caused by Streptococcus spp., Vibrio spp., and Edwardsiella piscicida , which cause significant economic losses in aquaculture. Antibiotics are mainly used to treat bacterial diseases. However, continued use of antibiotics causes bacterial resistance, which may lead to the transfer of antibiotic resistance genes. In our study, we isolated bacteria from the livers of cultured olive flounder from 34 farms on Jeju Island, South Korea. A total of 611 bacteria were isolated, of which 296 (48%) were Streptococcus parauberis by polymerase chain reaction (PCR) analysis. The isolates were tested for antibiotic susceptibility to 17 disks (including ampicillin, amoxicillin, erythromycin, tetracycline, oxytetracycline, and doxycycline) using disk diffusion. In addition, 13 antibiotic resistance genes were tested, including 9 tetracycline resistance genes (including tet (B) and tet (M)) and 4 macrolide resistance genes (including erm (B)). Data analysis of resistance levels were analyzed using normalized resistance interpretation (NRI) and multiple antibiotic resistance (MAR) index based on inhibition zones derived from the disk diffusion method. Antibiotic resistance genes were detected in all 296 isolates of S. parauberis . Tetracycline resistance genes were detected in 116 strains (39%) and macrolide resistance genes were identified in 96 strains (32%). The analysis of NRI resulted in CO wt values for 13 antibiotics, excluding the CO wt values for the four antibiotics sulfadiazine, oxolinic acid, nalidixic acid, and flumequine, which did not exhibit a normal distribution due to the dominance of non-wild types. Analysis of the multiple antibiotic resistance (MAR) showed that 39.9% of S. parauberis isolates had an MAR index of 0.22. The cut-off values presented in this study can be used as reference values for the disk diffusion method results because the experiment was performed on many S. parauberis . Future studies on antibiotic resistance of various fish pathogens should be conducted, with emphasis on alternate treatments.
Molecular Recognition and Discrimination of Amines with a Colorimetric Array (2005)

Seeing smells: Highly selective discrimination between closely related amines has been demonstrated by using an array of chemoresponsive dyes (see picture). Hierarchical classification of amines based on their colorimetric response is successful and matches that expected from qualitative structural and electronic considerations. High sensitivity (ca. 100 ppbv) has been shown for the detection and discrimination of amines. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2005/z500939_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Modeling structured activity to support human-robot collaboration in the presence of task and sensor uncertainty (2013)

©2013 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other users, including reprinting/ republishing this material for advertising or promotional purposes, creating new collective works for resale or redistribution to servers or lists, or reuse of any copyrighted components of this work in other works.
Atomic Force Microscopy Study of a Stretched Impact Copolymer (2012)

Nano-minerals are employed to enhance mineral bioavailability thus promoting the growth and well-being of animals. In recent times, nano-selenium (nano-Se) has garnered significant attention within the scientific community owing to its potential advantages in the context of poultry. This study was conducted to explore the impact of using variable levels of nano-Se on the growth performance, carcass characteristics, serum constituents, and gene expression in growing Japanese quails under both thermoneutral and heat stress conditions. A randomized experimental design was used in a 2 × 3 factorial, with 2 environmental conditions (thermoneutral and heat stress) and 3 nano-Se levels (0, 0.2, and 0.5 mg/kg of diet. The findings revealed that heat stress negatively affected the growth and feed utilization of quails; indicated by the poor BWG and FCR. Additionally, oxidative stress was aggravated under heat stress condition; indicated by increased lipids peroxidation and decreased antioxidant enzymes activities. The addition of nano-Se, especially at the level of 0.2 mg/kg of diet, significantly improved the performance of heat stressed quails and restored blood oxidative status. The expression profile of inflammatory and antioxidant markers was modulated by heat stress and/or 0.2 and 0.5 nano-Se in conjunction with environmental temperature in quail groups. In comparison to the control group, the heat stress-exposed quails' expression profiles of <i>IL-2, IL-4, IL-6</i>, and <i>IL-8</i> showed a notable up-regulation. Significantly lower levels of the genes for <i>IL-2, IL-4, IL-6</i>, and <i>IL-8</i> and higher levels of the genes for <i>SOD</i> and <i>GPX</i> as compared to the heat stress group demonstrated the ameliorative impact of 0.2 nano-Se. The expression profiles of <i>IL-2, IL-4, IL-6</i>, and IL-8 are dramatically elevated in quails exposed to 0.5 nano-Se when compared to the control group. <i>SOD</i> and <i>GPX</i> markers, on the other hand, were markedly down-regulated. It was concluded that nano-Se by low level in heat stressed growing quails provides the greatest performance and its supplementation can be considered as a protective management practice in Japanese quail diets to reduce the negative impact of heat stress.
Self -healing of ECC under cyclic wetting and drying (2005)

Peer Reviewed
Contrast-enhanced ultrasound for the diagnosis of acute pyelonephritis in pediatric patients with urinary tract infection: A feasibility study (2023)

CEUS can reveal renal perfusion defects in pediatric patients with suspected APN without radiation exposure or sedation; therefore, CEUS may be a feasible and valuable diagnostic technique.
Effect of the formation of secondary pores in zeolite ZSM-5 on the properties of molybdenum-zeolite catalysts for methane aromatization (2014)

A study is performed of 4% Mo/ZSM-5 (30) catalysts for methane aromatization prepared by solid-phase synthesis with mechanical mixing of a zeolite with MoO3 followed by calcination at 550°C. Zeolite etched with sodium hydroxide solutions and dealuminated with aluminum nitrate solutions is used as a support. Catalytic studies of the catalysts are conducted. The effect of treating the initial zeolite on the properties of catalysts in methane aromatization is determined. The effect subsequently treating a zeolite support has on the acid sites of a catalyst is confirmed by means of temperature-programmed reduction and the temperature-programmed desorption of NH3. The formation of molybdenum ions in the +5 oxidation state during catalysis and the presence of graphitized carbon deposits on a spent catalyst’s surface are confirmed by EPR and temperature-programmed oxidation.
Impact of PET‐2 guided treatment de‐escalation on time‐to‐recovery from cancer‐related fatigue in advanced stage Hodgkin Lymphoma: results from the GHSG HD18 study (2023)

Introduction: Persisting cancer related fatigue (CRF) has impact on health related quality of life (HRQoL) and social re-integration of patients with Hodgkin lymphoma (HL). The GHSG HD18 trial established treatment PET-2 guided de-escalation of treatment for advanced-stage HL as new standard. Here, we investigate the impact of treatment de-escalation in HD18 on long-term HRQoL domains and time-to-recovery from fatigue (TTR-F). Methods: Mean fatigue scores (FA) of the EORTC QLQ-C30 questionnaire are reported descriptively for baseline, interim, end-of-treatment, and yearly follow-up. TTR-F was defined as time from end of chemotherapy until first occurrence of FA <30 or the time of last questionnaire (censored). TTR-F was analyzed and compared using time-to-event methods including cumulative incidence and cox proportional hazard models, as recommended by the SISAQoL consortium. Effect of disease, patient and treatment characteristics on 2y HRQoL domains was analyzed using multiple regression. Results: 2101 patients aged 18–60 years with advanced-stage HL were recruited in HD18, of whom 156 were found ineligible before or after randomization. PET-2 negative Patients were randomized between 8x eBEACOPP (arm C, n = 288) and 4x eBEACOPP (arm D; n = 285), and between 6x eBEACOPP (arm C6; n = 216) and 4x eBEACOPP (D4; n = 216). HRQoL questionnaires at baseline were available in 83.9% of all randomized patients. Overall, baseline FA and age were significantly associated with TTR-F, whereas sex was not. TTR-F differed between trial arms for PET-2 negative, but not for PET-2 positive patients. Particularly, treatment reduction from 8 to 4 cycles of eBEACOPP led to a significantly shorter TTR-F (HR 1.41, p = 0.008). Reducing the cycle number of eBEACOPP from 8 to 6 cycles (HR 1.21, p = 0.2) or 6 to 4 cycles (HR 1.22, p = 0.18) speeded TTR-F accordingly but was not statistically significant. For PET-positive patients a significantly slower TTR-F was observed with addition of Rituximab (HR 0.7, p = 0.0163). In PET-2-negative patients, median TTR-F was 19 months (CI95: 13–28) in arm C, 13 months (CI95: 10–20) in arm C6, 12 months (CI95: 8–15) in arm D and 10 months (CI95: 8–13) arm D4. HRQoL at baseline and age were the main determinants of 2y HRQoL domains. The research was funded by: Deutsche Krebshilfe, Swiss State Secretariat for Education and Research, and Roche Pharma AG. Keywords: Chemotherapy, Hodgkin lymphoma, Late Effects in Lymphoma Survivors No conflicts of interests pertinent to the abstract.
High-Frequency Electron Paramagnetic Resonance Spectroscopy of the Apogalactose Oxidase Radical (1996)

The activated form of galactose oxidase from the fungus Dactylium dendroides contains a single divalent copper ion which is antiferromagnetically coupled to a protein-based free radical. Chemical oxidation of the apoenzyme generates the free radical which is localized on a covalently cross-linked tyrosine−cysteine residue. This species, together with model radicals generated by UV irradiation of protonated and selectively deuterated o-(methylthio)cresol (MTC), has been studied by high-frequency EPR spectroscopy (139.5 GHz/5 T) in conjunction with molecular orbital calculations employing self-consistent local density functional (LDF) methods. The Zeeman interactions (g values) determined from the high-frequency spectra of the apogalactose oxidase and the MTC model radicals are remarkably similar and support the assignment of the protein radical to a sulfur-substituted tyrosyl moiety. Molecular orbital calculations accurately reflect the experimental data, including an increase in the axial symmetry of the Zeeman interaction for the MTC radical compared with the unsubstituted tyrosyl radical species. An explanation of this effect based on an analysis of individual atomic contributions to the molecular g values is presented. High-frequency echo-detected EPR spectroscopy of the apogalactose oxidase radical resolves hyperfine splittings. Based on the molecular orbital calculations and the EPR spectroscopic results presented here, the hyperfine splittings are assigned to two methylene protonsone derived from tyrosine and one from cysteine. These findings are consistent with the radical spin density being localized on the tyrosine−cysteine moiety, rather than delocalized throughout an extended π-network involving a nearby tryptophan as had been previously suggested as a possible explanation of the stability of the radical species.
Supplementary Figure 5 from Preferential Replication of Systemically Delivered Oncolytic Vaccinia Virus in Focally Irradiated Glioma Xenografts (2023)

&lt;p&gt;PDF file - 93K&lt;/p&gt;
A guided search framework in multiple model control (2017)

The idea of using multiple models to cope with parameter uncertainties in adaptive systems was first introduced in the 1990s. Conventionally, methods based on this mechanism typically suffer from “curse of dimension,” which means that the number of required identification models grows exponentially with respect to the number of unknown parameters. In this paper, the parameter identification problem is formulated as a time-varying optimization procedure, and a guided multiple model search framework is proposed to solve it. Instead of sampling the identification models in a large parameter space, models are sampled locally and used to estimate the search direction. As a result, the number of needed identification models grows linearly in this approach, in comparison with the exponential growth of existing methods. The proposed method also provides a unified form for nonlinear systems with non-affine unknown parameters, which is out of the scope of classical adaptive control theory. Moreover, theoretical convergence analysis is provided with specific conditions. The effectiveness of the proposed approach is verified by simulations and comparisons with existing methods.
Proton minibeam radiation therapy for treating metastases: A treatment plan study (2023)

This work provides a first insight into the possibility of treating metastases with pMBRT. More favorable dose distributions and treatment delivery regimes may be expected from this new approach than SRT. The advantages of pMBRT would need to be confirmed by means of Phase I clinical trials.
Discovery of a Selective S1P1 Receptor Agonist Efficacious at Low Oral Dose and Devoid of Effects on Heart Rate (2011)

Gilenya (fingolimod, FTY720) was recently approved by the U.S. FDA for the treatment of patients with remitting relapsing multiple sclerosis (RRMS). It is a potent agonist of four of the five sphingosine 1-phosphate (S1P) G-protein-coupled receptors (S1P1 and S1P3-5). It has been postulated that fingolimod's efficacy is due to S1P1 agonism, while its cardiovascular side effects (transient bradycardia and hypertension) are due to S1P3 agonism. We have discovered a series of selective S1P1 agonists, which includes 3-[6-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-5-methyl-3,4-dihydro-2(1H)-isoquinolinyl]propanoate, 20, a potent, S1P3-sparing, orally active S1P1 agonist. Compound 20 is as efficacious as fingolimod in a collagen-induced arthritis model and shows excellent pharmacokinetic properties preclinically. Importantly, the selectivity of 20 against S1P3 is responsible for an absence of cardiovascular signal in telemetered rats, even at high dose levels.
Introduction to Department of Defense Research on Burn Pits, Biomarkers, and Health Outcomes Related to Deployment in Iraq and Afghanistan (2016)

Future research will examine the associations between demographic variables, smoking status, biomarker levels, and related health outcomes.
Video Games: Play That Can Do Serious Good. (2014)

The authors review recent research that reveals how today's video games instantiate naturally and effectively many principles psychologists, neuroscientists, and educators believe critical for learning. A large body of research exists showing that the effects of these games are much broader. In fact, some types of commercial games have been proven to enhance basic perceptual and cognitive skills. These effects are significant enough that educators use these games for such practical, real-world purposes as training surgeons and rehabilitating individuals with perceptual or cognitive deficits. Although many individuals may still consider video games nothing more than mindless fun, the authors argue that games serve also as serious tools for good.
A Modified Limiting Dilution Method for Monoclonal Stable Cell Line Selection Using a Real-Time Fluorescence Imaging System: A Practical Workflow and Advanced Applications (2021)

Stable cell lines are widely used in laboratory research and pharmaceutical industry. They are mainly applied in recombinant protein and antibody productions, gene function studies, drug screens, toxicity assessments, and for cancer therapy investigation. There are two types of cell lines, polyclonal and monoclonal origin, that differ regarding their homogeneity and heterogeneity. Generating a high-quality stable cell line, which can grow continuously and carry a stable genetic modification without alteration is very important for most studies, because polyclonal cell lines of multicellular origin can be highly variable and unstable and lead to inconclusive experimental results. The most commonly used technologies of single cell originate monoclonal stable cell isolation in laboratory are fluorescence-activated cell sorting (FACS) sorting and limiting dilution cloning. Here, we describe a modified limiting dilution method of monoclonal stable cell line selection using the real-time fluorescence imaging system IncuCyte<sup>®</sup>S3.
Similarity Learning for Well Logs Prediction Using Machine Learning Algorithms (2022)

Abstract Determining and predicting reservoir formation properties for newly drilled wells represents a significant challenge for oil and gas companies. Extensive well logs are available only while or after drilling, and thus they bear substantial financial, technical, and operational risks. We propose a new machine learning data-based model for determining well properties similarity and further derive and predict well logs before drilling in a specific geological context. Our model starts with selecting crucial well intervals and aggregation of vital features that determine the petrophysical properties related to particular well layers. Then, a machine-learning algorithm uses this info as input to provide a similarity score between wells. Our fast-to-train nonlinear data-based model is a variant of gradient boosting. We show that this approach can work well in complex scenarios with missing data and inconsistent similarity measures. We compare the modern machine learning algorithms for the evaluation of well similarity models based on aggregated features. The algorithms include gradient boosting and baseline logistic regression models. Our assessment for a real well log dataset via group cross-validation demonstrates that the gradient boosting model pretty accurately identifies well similarity. The receiver operating characteristic quality metric (ROC AUC) is 0.824. The developed similarity learning framework provides a data-driven approach towards estimating well logs for planned and newly drilled wells. Therefore, it allows prediction, improves determination, and can drive an optimal selection of log measurements to be executed in a new well in a specific field / geological context.
Camilo Castelo Branco, autor da literatura de cordel (2020)

A narrativa Maria! Não Me Mates, Que Sou Tua Mãe!, publicada pelo escritor português Camilo Castelo Branco, sob anonimato, em 1848, tem seduzido até hoje ouvintes e leitores com formações e gostos muito diferentes entre si. Este texto, uma das primeiras obras em prosa do autor da célebre novela romântica Amor de Perdição (1862), surgiu em folheto de cordel. O seu grande sucesso pode avaliar-se pelas várias edições que teve logo entre 1848 e 1852. Neste artigo, procuro compreender esta obra no contexto da produção literária de Camilo e da cultura portuguesa e europeia de meados do século XIX.