gebhart/patrepeval huggingface dataset:
Experimental Investigations Into Mixed Convection About a Horizontal Cylinder: Part A — Heat Transfer Using Digital Speckle Pattern Interferometry (2005)

Mixed convection heat transfer is commonly found in many engineering applications and is particularly relevant to the cooling of electronic components but despite this, the physics of this heat transfer regime is not fully understood. This paper presents an experimental study into buoyancy opposing cross flow, a commonly found mixed convection regime. The experimental configuration comprised a long heated cylinder suspended in a glass walled enclosure. The airflow within the enclosure was controlled using a baffled axial fan to give Reynolds numbers in the range of 32–89. The mean Nusselt numbers were measured about the cylinder for Rayleigh numbers between 1.7E+04–4.0E+04. For the acquisition of full field data the optical techniques, digital speckle pattern interferometry (DSPI) and phase measurement interferometry (PMI), were employed. Buoyancy opposing cross flow created an unsteady flow field about the cylinder at low Reynolds numbers and steady state temperatures. DSPI enabled real-time interferograms to be recorded and results are presented in the form of instantaneous interferograms showing the high frequency fluctuations of the temperature field about the cylinder. Attention is focused on understanding the trend in mean heat transfer values resulting from an increased inertia force and thus providing a significant insight into unsteady mixed convection flow.
Finite Element Modeling of the Left Atrium to Facilitate the Design of an Endoscopic Atrial Retractor (2007)

A finite element model of the left atrium, incorporating detailed anatomical features and realistic material characteristics, was built to investigate the interaction of heart tissue and surgical instruments. This model was used to facilitate the design of an endoscopically deployable atrial retractor for use in minimally invasive, robotically assisted (MIRA) mitral valve repair. The left atrial geometry was imported directly from MRI data of an explanted porcine heart, and material properties were derived from experimental testing of cardiac tissues. Model accuracy was verified by comparing simulated cardiac wall deflections to those measured by MRI. Finite element analysis was shown to be an effective tool for analyzing instrument/tissue interactions and for designing surgical instruments.
Palladium‐catalyzed amination with benzophenone imine as a new, safe and practical alternative to nitration for the synthesis of 7‐amino‐2,1,3‐benzothiadiazoles (2003)

Abstract Palladium‐catalyzed amination of 7‐bromo‐4‐methyl‐2,1,3‐benzothiadiazole ( 7 ) with benzophenone imine as an ammonia equivalent is described as a new, safe and practical alternative to nitration for the synthesis of 7‐amino‐4‐methyl‐2,1,3‐benzothiadiazole ( 1 ) in high yield. This methodology was successfully scaled‐up in the pilot plant on 14.0‐kg scale of 7 and was also utilized for the synthesis of 7‐amino‐4,6‐dimethyl‐2,1,3‐ben‐zothiadiazole ( 12 ) by the amination of 7‐bromo‐4,6‐dimethyl‐2,1,3‐benzothiadiazole ( 10 ).
Evolution and future prospects of inorganic photovoltaics (2004)

Inorganic semiconductors are the backbone of present day photovoltaic (PV) technologies. The highest performance solar cells use III-V based materials in complex multijunction device structures and are used primarily in the space industry. The crystalline Si technologies are the mainstay of the commercial terrestrial markets and range from single crystal through large grain polycrystalline materials. Thin film PV technologies, which are approaching large scale manufacturing production levels, consist of polycrystalline CdTe, CuInSe2 and related alloys, and amorphous silicon (a-Si) and related alloys. The paper provides an historical background on the development of these inorganic PV technologies, followed by a discussion of the present status of each technology. The future directions being pursued to improve performance will also be discussed with emphasis on synergies between the technologies.
Ion Migration through a Polymer Solution:  Microviscosity (2003)

The ion migration in polymer solutions of different molecular weights is investigated by conductometry for various inorganic salts. The electric conductivity κ declines with increasing the number concentration of polymer cp at a given salt concentration cs. All reduced conductivities for salts of the same valency type collapse into a single curve for a given polymer molecular weight and can be well represented by the simple exponential κ = κ0(cs) exp(−[κ]cp). Here κ0 is the conductivity of the salt solution in the absence of polymers, and [κ] can be regarded as an intrinsic attenuation factor. Our result indicates that the reduction of the ion mobility is mainly attributed to hydrodynamic interactions between the probe ion and polymer segments, and the specific ion effect plays a minor role. The intrinsic attenuation factor is found to be independent of the salt concentration but to vary with polymer molecular weight Mw, [κ] ∝ Mw. This consequence reveals that the ion interacts with all segments of a polymer as it migrates through the coil or the network, and hence the conductivity reduction depends mainly on the polymer weight concentration.
A practical approach for belt slip detection in automotive electric power generation and storage system (2010)

This paper addresses a specific fault detection and isolation (FDI) issue within the automotive electric power generation and storage (EPGS) system, i.e., the detection of belt slip. A practical model-based algorithm is proposed to detect the belt slip and estimate the belt-slip size using sensors that are currently available in most of the production vehicles, which limits the cost and is especially desirable for the cost-sensitive automotive industry. This paper presents the derivation of the proposed algorithm, the calibration procedure, together with some simulation experiment results.
Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity (2020)

Tumour cell phagocytosis by antigen presenting cells (APCs) is critical to the generation of antitumour immunity. However, cancer cells can evade phagocytosis by upregulating anti-phagocytosis molecule CD47. Here, we show that CD47 blockade alone is inefficient in stimulating glioma cell phagocytosis. However, combining CD47 blockade with temozolomide results in a significant pro-phagocytosis effect due to the latter's ability to induce endoplasmic reticulum stress response. Increased tumour cell phagocytosis subsequently enhances antigen cross-presentation and activation of cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) in APCs, resulting in more efficient T cell priming. This bridging of innate and adaptive responses inhibits glioma growth, but also activates immune checkpoint. Sequential administration of an anti-PD1 antibody overcomes this potential adaptive resistance. Together, these findings reveal a dynamic relationship between innate and adaptive immune regulation in tumours and support further investigation of phagocytosis modulation as a strategy to enhance cancer immunotherapy responses.
Morphogenesis of poliovirus III. Formation of Provirion in Cell-Free Extracts (1973)

Formation of an apparent virion precursor, the provirion, can be demonstrated in cytoplasmic extracts of poliovirus-infected HeLa cells.
High Efficiency Wireless Power Transmission with Digitally Configurable Stimulation Voltage for Retinal Prosthesis (2005)

Electrical stimulation of retinal neuron cells has been used to invoke perception of sight in legally blind patients due to loss of photoreceptors. In such a prosthetic device, one of the challenges is that the required stimulation voltage varies among patients and also over time. The voltage supply to the stimulator circuits should adapt to these changes for optimal device operation. This paper presents a closed loop wireless power transmission system, which can digitally adjust the voltage. In the system, power is wirelessly transmitted to the secondary side (implant) through a magnetically coupled coil pair. The secondary side wirelessly transmits information about the recovered voltage back to the primary side, which accordingly adjusts the amount of power transmitted and thus maintains the voltage in the implant at the required value. Experimental results verify that the voltage can be effectively configured with power savings up to 30%
Apparent Usher Syndrome Caused by the Combination ofBBS1-Associated Retinitis Pigmentosa andSLC26A4-Associated Deafness (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Ophthalmology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Ophthalmology journal
The Helicobacter pylori neutrophil‐activating protein is an iron‐binding protein with dodecameric structure (1999)

The neutrophil-activating protein (HP-NAP) of Helicobacter pylori is a major 17 kDa antigen of the immune response of infected individuals. Amino acid sequence comparison indicated a high similarity between HP-NAP and both bacterial DNA-protecting proteins (Dps) and ferritins. The structure prediction and spectroscopic analysis presented here indicate a close similarity between HP-NAP and Dps. Electron microscopy revealed that HP-NAP forms hexagonal rings of 9-10 nm diameter with a hollow central core as seen in Dps proteins, clearly different from the 12 nm icositetrameric (24 subunits) ferritins. However, HP-NAP is resistant to thermal and chemical denaturation similar to the ferritin family of proteins. In addition, HP-NAP binds up to 40 atoms of iron per monomer and does not bind DNA. We therefore conclude that HP-NAP is an unusual, small, ferritin that folds into a four-helix bundle that oligomerizes into dodecamers with a central hole capable of binding up to 500 iron atoms per oligomer.
ChemInform Abstract: ALKYLTIN(IV)‐MEDIATED CARBOCYCLIZATION (1980)

Abstract Unter dem Einfluß von TiCl 4 bildet die α,β‐Enon‐Gruppe des Ketons (I) ein elektrophiles Zentrum aus, das mit der C‐Sn‐a‐ Bindung unter Ringschluß zu den cis/trans‐isomeren Decalonen (II) reagiert (cis:trans = 97:3 bei 40°C und 33:68 bei ‐78°C).
Expected performance of digital scanner and the potential application for advanced semiconductor fabrication (2023)

The first planned Digital Scanner product, DS248, will have the optical resolution of 110 nm and overlay accuracy of less than 10 nm, the same level as a KrF mask scanner. In addition, DS248 has more application areas, such as individual chip customization and large-area printing up to wafer size, with KrF resolution, which are not possible with the current mask scanner but will be beneficial for performance enhancement of semiconductor devices in future. The latest exposure results of DS-POC, which has the similar imaging performance with DS248, are introduced including chip ID exposure on entire 200 mm wafer and exposure of wafer scale integration substrate. Simulation data of high aspect ratio patterning with high resolution by means of integration of multiple heads of solid-state laser is described. Development progress of DS’s pixel mask conversion software that directly generates pixel mask from target pattern with OPC is reported.
Kinetics of antifreeze protein‐induced ice growth inhibition (1997)

Antifreeze proteins (AFPs) depress the freezing temperature of a solution in a non-colligative manner, by arresting the growth of ice crystals. The kinetics of this effect, studied here for the first time using a new technique called temperature gradient thermometry, are consistent with an adsorption-mediated inhibitory mechanism. The results obtained by this approach provide a new experimental basis for understanding AFP interaction with ice.
Simple flow cytometric detection of haemozoin containing leukocytes and erythrocytes for research on diagnosis, immunology and drug sensitivity testing (2011)

A simple modification of a flow cytometer allows for rapid and reliable detection and quantification of Hz-containing leukocytes and the analysis of differential surface marker expression in the same sample of Hz-containing versus non-Hz-containing leukocytes. Importantly, it distinguishes different maturation stages of parasitized RBC and may be the basis of a rapid no-added-reagent drug sensitivity assay.
A 133 MHz 170 mW 10 μA standby application processor for 3G cellular phones (2003)

An application processor for 3G cellular phones, using 0.18 /spl mu/m CMOS technology, includes a single CPU and DSP core with an on-chip 128 kB SRAM. It enables software-based 15 frames/s MPEG-4 encoding of QCIF Simple @L1 at 70 MHz and 140 mW. Standby current of the processor is <10 /spl mu/A in a partially powered standby mode using separate power lines.
SH-Mobile-Low Power Application Processor for Cellular (2005)

Renesas Technology Corp. gains world wide support in the field of application processors for cellular phones (SH-mobile), where various performance demanding applications must be handled with very low power consumption. Techniques of the SH-mobile to reduce leakage current, such as a partial power shut down mechanism and a methodology of multi-threshold transistors are introduced. Also advantages of the SH-mobile architecture, such as dual CPU core, large internal memory, and various media accelerators, are described from a low power consumption point of view.
Erratum: Proteomic analyses of monocytes obtained from Hispanic women with HIV‐associated dementia show depressed antioxidants (2010)

are corrected as follows:Experimental design: To this end, we studied the proteome of blood-derived monocytes obtained from Hispanic women with the most severe form of HIV-associated neurocognitive disorder, HIV-associated dementia (HAD).Monocytes isolated from peripheral blood mononuclear cells by CD141 immunoaffinity column chromatography were 495% pure.Cells were recovered from five patients without evidence of cognitive impairment and four with HAD and analyzed by 2-D DIGE and tandem MS.
Linear cell radar system using radio-over-fiber links (2018)

This paper describes overview of linear cell radar systems consisting of many millimeter-wave radar units connected by radio-over-fiber links. The liner cell radar system can provide high-resolution imaging with linear shape coverage for airport runways, railway tracks or motorways. We review performance of linear cell radars and discuss issues of interference between radar units.
Paramagnetic aluminium–1,4-di-t-butyl-1,4-diazabutadiene (dbdab) complexes derived from metal vapours and/or metal hydrides: crystal structures of [Al(dbdab)2] and [Al(dbdab){N(But)CH2}2] (1990)

Reaction of aluminium vapour or LiAlH4–aluminium metal–hexane with 1,4-di-t-butyl-1,4-diazabutadiene (dbdab) yields dark green [Al(dbdab)2](1), whereas AlH3·NMe3 with dbdab in hexane at –80°C yields the corresponding hydroalumination product [Al(dbdab){N(But)CH2}2](2) as a yellow solid; although both compounds are paramagnetic, XPS (solid) and EPR (solution) spectroscopy, and X-ray structure determinations support formally AlIII centres with the unpaired electron ligand-centred.
The rise of the 3rd dimension for system intergration (2006)

Electronic interconnection and packaging is mainly performed in a planar, 2D design style. Further miniaturization and performance enhancement of electronic systems will more and more require the use of 3D interconnection schemes. Key technologies for realizing true 3D interconnect schemes are the realization of vertical connections, either through the Si-die or through the multilayer interconnect with embedded die. Different applications require different complexities of 3D-interconnectivity. Therefore, different technologies may be used. These can be categorized as a more traditional packaging approach, a wafer-level-packaging, WLP (`above' passivation), approach and a foundry level (`below' passivation) approach. We define these technologies as respectively 3D-SIP, 3D-WLP and 3D-SIC. In this paper, these technologies are discussed in more detail
Ultra-Fast Compact Plasmonic Modulator based on Adiabatic Coupled Waveguides (2018)

Compact plasmonic modulator based on adiabatic coupled waveguides obtains insertion loss as low as <0.1 dB with the extinction ratio exceeding 40 dB. In addition the speed of 400 GHz with footprint of 2.7 um2 is expected.
Acquired Thymic Tolerance: Role of CTLA4 in the Initiation and Maintenance of Tolerance in a Clinically Relevant Autoimmune Disease Model (1999)

Injection of Ag into the thymus of adult animals induces specific systemic tolerance. The mechanisms of acquired thymic tolerance include anergy and the deletion of Ag-specific T cells. Here, we report that anergy to nominal Ag induced via acquired thymic tolerance requires CTL-associated Ag 4 (CTLA4) engagement. The role of CTLA4 in the induction and maintenance of tolerance was then investigated in the murine experimental autoimmune encephalomyelitis model. CTLA4 blockade abrogated the induction but not the maintenance phase of acquired thymic tolerance induced by intrathymic injection of myelin Ags. In addition, CTLA4 blockade had a restricted window of action after priming with Ag, which is consistent with the expression patterns of CTLA4 in vivo. We conclude that: 1) the induction of acquired thymic tolerance requires signaling through CTLA4 and 2) CTLA4 does not appear to be required for the maintenance of acquired thymic tolerance. This is the first report documenting the role of a CTLA4 negative signaling pathway in the induction of tolerance in an autoimmune disease model.
A novel iterative method for approximating frequency response with equivalent pole/residues (2016)

Frequency domain modeling of interconnects has become the de facto standard for characterization in high-speed signal and power delivery systems. But time domain system level performance analysis calls for pole/residue representation followed by circuit level synthesis from the frequency domain sampled data model of interconnects. In this paper, a new iterative method that produces a set of equivalent poles and residues from discrete sampled frequency response data is proposed. Each iteration picks a few consecutive points from the given sampled response, identifies a local transfer function that matches their response and reduces error by subtracting the local transfer function. Two test cases, strip-line and package, are demonstrated. And results show that the proposed method has potential in fitting system frequency responses and has wide applications in signal and power integrity modeling and simulation of interconnect networks.
Development of a PC12 cell-based assay for in vitro screening of catechol- O -methyltransferase inhibitors (2019)

ABSTRACT The male rat adrenal pheochromocytoma cell-originated PC12 cell line can synthesize and release catecholamine neurotransmitters, and it has been widely used as a model system in cell biology and toxicology research. Catechol- O -methyltransferase (COMT) is involved in the inactivation of the catecholamine neurotransmitters, and it is particularly important for theregulation of dopamine. In this study, we explored the feasibility of using PC12 cells as an in vitro drug screening platform to compare the activity of multiple COMT inhibitors. Incubation of PC12 cells with tolcapone, a highly potent and selective COMT inhibitor, increased the concentrations of dopamine and its metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) while reducing the metabolites 3-methoxytyramine (3-MT) and homovanillic acid (HVA) in the cell culture medium. LIBD-3, a novel, non-nitrocatechol COMT inhibitor produced similar effects compared to tolcapone. LIBD-4, a less potent inhibitor, exhibited the expected right-shift in functional inhibition in the assay. These results match the known in vivo effects of COMT inhibition in rodents. Together, these data support the continued use of PC12 cells as an in vitro screen that bridges cell-free enzyme assays and more costly in vivo assays.
Stimulation of Healing of Chronic Wounds by Epidermal Growth Factor (1991)

Brown, Gregory L. M.D.; Curtsinger, Luke M.D.; Jurkiewicz, Maurice J. M.D.; Nahai, Foad M.D.; Schultz, Gregory Ph.D.; Robson, Martin C. M.D. Author Information
Low‐Cost Hydrogen‐Evolution Catalysts Based on Monolayer Platinum on Tungsten Monocarbide Substrates (2010)

Wer bietet weniger? Die kleinstmögliche Menge an Platin, eine Monoschicht oder weniger, wurde bezüglich ihrer Fähigkeit zur Wasserstoffentwicklung untersucht. Eine Platinmonoschicht (graublaue Kugeln) auf dem billigen Substrat Wolframmonocarbid (W blaue, C dunkelgraue Kugeln) entwickelte als Elektrokatalysator Wasserstoff mit derselben Aktivität wie ein Platinblock. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.